Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SYNE4	163183	broad.mit.edu	37	19	36498048	36498048	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:36498048C>G	ENST00000324444.3	-	3	513	c.402G>C	c.(400-402)caG>caC	p.Q134H	SYNE4_ENST00000340477.5_Intron	NM_001039876.1	NP_001034965.1			spectrin repeat containing, nuclear envelope family member 4																		CCATCCCACTCTGGGCCAATG	0.667000													3	10					0	0	1	0	0
SEPT12	124404	broad.mit.edu	37	16	4833737	4833737	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr16:4833737C>T	ENST00000268231.8	-	6	806	c.543G>A	c.(541-543)caG>caA	p.Q181Q	SEPT12_ENST00000396693.5_Silent_p.Q135Q	NM_144605.4	NP_653206.2	Q8IYM1	SEP12_HUMAN	septin 12	181					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|skin(2)|stomach(3)	23						GGCACAGCCGCTGCAGGAACT	0.652000													31	19					0	0	1	0	0
HTR5A	3361	broad.mit.edu	37	7	154863348	154863348	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr7:154863348G>T	ENST00000287907.2	+	1	1315	c.739G>T	c.(739-741)Gag>Tag	p.E247*		NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	247						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CGAAGCTGTGGAGGTGGGTAT	0.522000													27	25					1.88708e-17	2.15146e-17	1	1	0
MCM9	254394	broad.mit.edu	37	6	119252823	119252823	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr6:119252823C>G	ENST00000316316.6	-	2	352	c.66G>C	c.(64-66)aaG>aaC	p.K22N	MCM9_ENST00000316068.3_Missense_Mutation_p.K22N	NM_017696.2	NP_060166.2	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	22					DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		GAATATCATTCTTATGGTATT	0.373000													19	54					0	0	1	0	0
C17orf98	388381	broad.mit.edu	37	17	36993426	36993426	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr17:36993426C>T	ENST00000398575.4	-	2	340	c.275G>A	c.(274-276)aGa>aAa	p.R92K		NM_001080465.2	NP_001073934.1	A8MV24	CQ098_HUMAN	chromosome 17 open reading frame 98	92								p.R92I(1)		endometrium(5)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|prostate(3)	14						GTTGAGGTATCTTTGTCCTTG	0.522000													83	39					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25463917	25463917	+	RNA	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr15:25463917C>A	ENST00000424208.1	+	0	2994				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						TATTTTGGACCTGGGACCTGG	0.577000													53	39					4.0306e-16	4.57318e-16	1	1	0
FLNC	2318	broad.mit.edu	37	7	128478368	128478368	+	Silent	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr7:128478368G>A	ENST00000325888.8	+	7	1356	c.1095G>A	c.(1093-1095)gaG>gaA	p.E365E	FLNC_ENST00000346177.6_Silent_p.E365E	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	365					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GTCCCTTTGAGGTGAACGTGG	0.582000													29	71					0	0	1	0	0
ZNF547	284306	broad.mit.edu	37	19	57883219	57883219	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:57883219C>G	ENST00000282282.3	+	3	244	c.94C>G	c.(94-96)Cag>Gag	p.Q32E	AC003002.4_ENST00000597658.1_Missense_Mutation_p.Q32E	NM_173631.2	NP_775902.2	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CGATGAGGCTCAGAGATTGCT	0.512000													69	336					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74288358	74288358	+	Missense_Mutation	SNP	A	A	T	rs113162124	byFrequency	TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr17:74288358A>T	ENST00000262765.5	-	4	2131	c.1952T>A	c.(1951-1953)gTt>gAt	p.V651D		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	651	Gln-rich.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						accacgctgaactgcaccagg	0.542000													5	155					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47918946	47918946	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:47918946C>T	ENST00000426837.2	-	11	5589	c.5502G>A	c.(5500-5502)ccG>ccA	p.P1834P	MAP4_ENST00000462206.1_5'UTR|MAP4_ENST00000441748.2_5'UTR|MAP4_ENST00000264724.11_Silent_p.P424P|MAP4_ENST00000395734.3_Silent_p.P689P|MAP4_ENST00000360240.6_Silent_p.P689P|MAP4_ENST00000420772.2_Silent_p.P512P|MAP4_ENST00000383737.4_Silent_p.P417P			P27816	MAP4_HUMAN	microtubule-associated protein 4	689					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GCTCCTTGTTCGGTGGGGTGG	0.493000													25	19					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34003481	34003481	+	Silent	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr6:34003481G>A	ENST00000374181.3	-	8	2575	c.2406C>T	c.(2404-2406)atC>atT	p.I802I	GRM4_ENST00000374177.3_Silent_p.I686I|GRM4_ENST00000535756.1_Silent_p.I669I|GRM4_ENST00000538487.1_Silent_p.I802I|GRM4_ENST00000544773.1_Silent_p.I633I|GRM4_ENST00000545715.1_Silent_p.I494I|GRM4_ENST00000455714.2_Silent_p.I662I	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	802					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	AGAAGATGGGGATGAAGGCCA	0.622000													7	26					0	0	1	0	0
GSPT1	2935	broad.mit.edu	37	16	11981428	11981428	+	Splice_Site	SNP	A	A	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr16:11981428A>C	ENST00000434724.2	-	7	1155	c.957_splice	c.e7+1	p.L319_splice	GSPT1_ENST00000563468.1_Splice_Site_p.L181_splice|GSPT1_ENST00000439887.2_Splice_Site_p.L318_splice|GSPT1_ENST00000420576.2_Splice_Site_p.L181_splice|RP11-166B2.8_ENST00000574364.1_RNA	NM_001130006.1|NM_002094.3	NP_001123478.1|NP_002085.2	P15170	ERF3A_HUMAN	G1 to S phase transition 1	181					G1/S transition of mitotic cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation	intracellular	GTP binding|GTPase activity|protein binding|translation release factor activity			breast(1)|central_nervous_system(1)|kidney(4)|lung(4)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	14						CTTTCTTACCAGCACAGCCAA	0.393000													20	147					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43922358	43922358	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:43922358T>C	ENST00000282406.4	+	6	607	c.497T>C	c.(496-498)cTa>cCa	p.L166P		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	166						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CAGTCAAAACTACAAGGTACA	0.313000													75	6					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137294343	137294343	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr7:137294343C>A	ENST00000453654.1	-	9	645	c.106G>T	c.(106-108)Gct>Tct	p.A36S	DGKI_ENST00000424189.2_Missense_Mutation_p.A336S|DGKI_ENST00000288490.5_Missense_Mutation_p.A336S|DGKI_ENST00000446122.1_Missense_Mutation_p.A336S			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	336					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						CGATTTGAAGCCTTCAGGGAG	0.463000													8	46					0.000673444	0.000691012	1	1	0
PCDHA12	56137	broad.mit.edu	37	5	140256763	140256763	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr5:140256763C>T	ENST00000398631.2	+	1	1706	c.1706C>T	c.(1705-1707)cCg>cTg	p.P569L	PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA10_ENST00000506939.2_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGCGACTCCGGCTGGCAGC	0.716000													104	71					0	0	1	0	0
PRKAG3	53632	broad.mit.edu	37	2	219689278	219689278	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:219689278G>A	ENST00000439262.2	-	11	1210	c.1115C>T	c.(1114-1116)tCc>tTc	p.S372F	PRKAG3_ENST00000392098.3_3'UTR|PRKAG3_ENST00000529249.1_Missense_Mutation_p.S397F|PRKAG3_ENST00000545803.1_Missense_Mutation_p.S213F	NM_017431.2	NP_059127.2	Q9UGI9	AAKG3_HUMAN	protein kinase, AMP-activated, gamma 3 non-catalytic subunit	397	CBS 3.				cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			large_intestine(7)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATCAAAGCGGGAATAGAGGCC	0.627000													41	22					0	0	1	0	0
ACAD9	28976	broad.mit.edu	37	3	128628911	128628911	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:128628911C>T	ENST00000308982.7	+	16	1692	c.1611C>T	c.(1609-1611)ctC>ctT	p.L537L	ACAD9_ENST00000511526.1_3'UTR|RP11-723O4.6_ENST00000508239.1_3'UTR|KIAA1257_ENST00000511438.1_3'UTR	NM_014049.4	NP_054768.2	Q9H845	ACAD9_HUMAN	acyl-CoA dehydrogenase family, member 9	537						mitochondrion	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	30						CCAACATCCTCATCAACCTGT	0.632000													9	15					0	0	1	0	0
RIOK3	8780	broad.mit.edu	37	18	21043044	21043044	+	Splice_Site	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr18:21043044G>A	ENST00000339486.3	+	2	796		c.e2+1		RIOK3_ENST00000577501.1_Splice_Site|RIOK3_ENST00000581585.1_Splice_Site	NM_003831.3	NP_003822.2	O14730	RIOK3_HUMAN	RIO kinase 3						chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(3)|ovary(2)	10	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CTGAAGTTGCGTAAGTAAAAT	0.363000													20	118					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103074410	103074410	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:103074410A>G	ENST00000375735.2	+	51	8360	c.8216A>G	c.(8215-8217)tAt>tGt	p.Y2739C	DYNC2H1_ENST00000398093.3_Missense_Mutation_p.Y2739C|DYNC2H1_ENST00000334267.7_Intron	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2739	AAA 4 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CCTGGACTCTATACTCTTGAA	0.308000													12	27					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16021623	16021623	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr8:16021623C>T	ENST00000350896.3	-	5	965	c.768G>A	c.(766-768)ctG>ctA	p.L256L	MSR1_ENST00000262101.5_Silent_p.L256L|MSR1_ENST00000355282.2_Silent_p.L256L|MSR1_ENST00000445506.2_Silent_p.L274L|MSR1_ENST00000536385.1_Silent_p.L30L|MSR1_ENST00000381998.4_Silent_p.L256L	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	256					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CCCAATCTTTCAGTCTGAGAT	0.313000													8	32					0	0	1	0	0
ZNF44	51710	broad.mit.edu	37	19	12384756	12384756	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:12384756C>T	ENST00000356109.5	-	5	576	c.458G>A	c.(457-459)aGc>aAc	p.S153N	ZNF44_ENST00000355684.5_Missense_Mutation_p.S105N	NM_001164276.1	NP_001157748.1	P15621	ZNF44_HUMAN	zinc finger protein 44	153					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		ATTCACACTGCTTCCACATGC	0.428000													26	94					0	0	1	0	0
WWC1	23286	broad.mit.edu	37	5	167858265	167858265	+	Missense_Mutation	SNP	G	G	A	rs148388652		TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr5:167858265G>A	ENST00000265293.4	+	15	2598	c.2096G>A	c.(2095-2097)cGc>cAc	p.R699H	WWC1_ENST00000521089.1_Missense_Mutation_p.R699H	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	699	C2.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		AGGAATATCCGCGTGGCTGTC	0.527000													18	50					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5754141	5754141	+	Splice_Site	SNP	A	A	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:5754141A>G	ENST00000381624.3	+	13	1225		c.e13-1		CATSPERD_ENST00000381614.2_Splice_Site|CATSPERD_ENST00000309164.7_Splice_Site	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta							integral to membrane											CTTTTTAACTAGATAGAGTTT	0.473000													24	99					0	0	1	0	0
GRXCR2	643226	broad.mit.edu	37	5	145239439	145239439	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr5:145239439C>T	ENST00000377976.1	-	3	603	c.604G>A	c.(604-606)Ggg>Agg	p.G202R		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	202										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						CTGCCCGACCCTCGGCAGTGA	0.557000													7	29					0	0	1	0	0
ZNF93	81931	broad.mit.edu	37	19	20045185	20045185	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:20045185T>A	ENST00000343769.5	+	4	1449	c.1421T>A	c.(1420-1422)aTt>aAt	p.I474N	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	474						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.I474N(1)		endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						CATAAGAAAATTCATACTGGA	0.363000													4	139					0	0	1	0	0
AK9	221264	broad.mit.edu	37	6	109814728	109814728	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr6:109814728C>T	ENST00000424296.2	-	41	5656	c.5580G>A	c.(5578-5580)aaG>aaA	p.K1860K	RP5-919F19.5_ENST00000423747.1_RNA	NM_001145128.2	NP_001138600.2			adenylate kinase 9																		GCTCCATCTTCTTCTTATACT	0.368000													20	44					0	0	1	0	0
EFNB1	1947	broad.mit.edu	37	X	68060417	68060417	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chrX:68060417A>T	ENST00000204961.4	+	5	1741	c.961A>T	c.(961-963)Agt>Tgt	p.S321C		NM_004429.4	NP_004420.1	P98172	EFNB1_HUMAN	ephrin-B1	321					cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	22						TGAGAAGGTGAGTGGGGACTA	0.612000													5	13					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106209287	106209287	+	RNA	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr14:106209287C>T	ENST00000390548.2	-	0	121																											GCCTGAGTTCCACGACACCGT	0.662000													24	8					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685640	248685640	+	Silent	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:248685640T>C	ENST00000343414.4	+	1	725	c.693T>C	c.(691-693)gcT>gcC	p.A231A		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TAAAATCAGCTGCGGGCCGCC	0.458000													4	137					0	0	1	0	0
DNASE1L3	1776	broad.mit.edu	37	3	58179051	58179051	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:58179051G>C	ENST00000483681.1	-	9	1401	c.820C>G	c.(820-822)Ctt>Gtt	p.L274V	DNASE1L3_ENST00000394549.2_Intron|DNASE1L3_ENST00000318316.3_Intron|DNASE1L3_ENST00000486455.1_Intron			Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3	0					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(4)|lung(6)	12				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		GGCATAGAAAGACAAGATGGC	0.413000													14	31					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103230261	103230261	+	Silent	SNP	A	A	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr7:103230261A>G	ENST00000428762.1	-	28	4086	c.3927T>C	c.(3925-3927)tgT>tgC	p.C1309C	RELN_ENST00000343529.5_Silent_p.C1309C|RELN_ENST00000424685.2_Silent_p.C1309C	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1309					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATTGATTGGCACAACCTATGT	0.428000													72	20					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039314	11039314	+	RNA	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr21:11039314C>T	ENST00000470054.1	-	0	889									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGTTTTCTGTCACTTCCATTT	0.368000													9	512					0	0	1	0	0
TM9SF2	9375	broad.mit.edu	37	13	100153989	100153989	+	Silent	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr13:100153989C>A	ENST00000376387.4	+	1	319	c.129C>A	c.(127-129)ccC>ccA	p.P43P		NM_004800.1	NP_004791.1	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2	43					transport	endosome membrane|integral to plasma membrane		p.P43P(1)		endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)	17	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					GCCTGGCGCCCGTCAACTTCT	0.657000													19	57					8.34094e-07	8.94755e-07	1	1	0
TRIM42	287015	broad.mit.edu	37	3	140409995	140409995	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:140409995C>T	ENST00000286349.3	+	4	2237	c.2046C>T	c.(2044-2046)atC>atT	p.I682I		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	682	Fibronectin type-III.					intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						TTAGAGCCATCAATGATAATG	0.433000													29	127					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5782304	5782304	+	Missense_Mutation	SNP	C	C	T	rs56856085	by1000genomes	TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr10:5782304C>T	ENST00000328090.5	+	13	2796	c.2171C>T	c.(2170-2172)tCt>tTt	p.S724F	RP11-336A10.2_ENST00000411512.2_RNA	NM_017782.4	NP_060252.4	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	724			S -> Y (in dbSNP:rs56856085).														CGACCACCGTCTGCCCGTGTG	0.488000													27	52					0	0	1	0	0
ARFGAP1	55738	broad.mit.edu	37	20	61910339	61910339	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr20:61910339C>T	ENST00000370275.4	+	7	711	c.619C>T	c.(619-621)Ctg>Ttg	p.L207L	ARFGAP1_ENST00000370283.4_Silent_p.L207L|ARFGAP1_ENST00000353546.3_Silent_p.L207L|ARFGAP1_ENST00000519273.2_Silent_p.L94L|ARFGAP1_ENST00000519604.1_Silent_p.L154L|ARFGAP1_ENST00000547204.1_Silent_p.L133L			Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating protein 1	207					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)	13	all_cancers(38;1.59e-09)					CATGTCCTCCCTGTACTCGGT	0.602000													14	49					0	0	1	0	0
FAM92A1P2	403315	broad.mit.edu	37	4	183960166	183960166	+	RNA	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr4:183960166C>T	ENST00000502308.1	+	0	1349					NR_003612.1																						CACCAGAGATCATGTCAGCTA	0.388000													3	19					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228463619	228463619	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:228463619G>A	ENST00000570156.2	+	25	7311	c.7237G>A	c.(7237-7239)Gag>Aag	p.E2413K	RP5-1139B12.3_ENST00000602947.1_RNA|RP5-1139B12.3_ENST00000602529.1_RNA|OBSCN_ENST00000284548.11_Missense_Mutation_p.E2038K|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000359599.6_Missense_Mutation_p.E885K|OBSCN_ENST00000422127.1_Missense_Mutation_p.E2038K	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1401					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GATCCACGCCGAGGGCGCCCG	0.667000													9	16					0	0	1	0	0
DDX18	8886	broad.mit.edu	37	2	118583876	118583876	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:118583876G>C	ENST00000263239.2	+	11	1681	c.1553G>C	c.(1552-1554)aGa>aCa	p.R518T		NM_006773.3	NP_006764.3	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	518	Helicase C-terminal.						ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						AGAACAGCCAGAGGCCTAAAT	0.453000													25	56					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144930693	144930693	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:144930693C>T	ENST00000529945.1	-	1	1455	c.1016G>A	c.(1015-1017)aGg>aAg	p.R339K	PDE4DIP_ENST00000369349.3_Intron|PDE4DIP_ENST00000369351.3_Intron|PDE4DIP_ENST00000369356.4_Intron|PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.R339K|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000369354.3_Intron|PDE4DIP_ENST00000479408.2_Intron|PDE4DIP_ENST00000530740.1_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTTCAAAGACCTGTTAAGGAA	0.522000			T	PDGFRB	MPD								106	168					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612098	20612098	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr14:20612098A>C	ENST00000333629.1	+	1	204	c.204A>C	c.(202-204)ttA>ttC	p.L68F		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		ACTTGGCCTTACTGGATGCAT	0.478000													5	245					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44890538	44890538	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr15:44890538T>G	ENST00000261866.7	-	23	3942	c.3926A>C	c.(3925-3927)aAg>aCg	p.K1309T	SPG11_ENST00000558319.1_Missense_Mutation_p.K1309T|SPG11_ENST00000427534.2_Missense_Mutation_p.K1309T|SPG11_ENST00000535302.2_Missense_Mutation_p.K1309T	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	1309					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TGTGGTTGTCTTTTCACCATC	0.373000													17	57					0	0	1	0	0
LYPLAL1	127018	broad.mit.edu	37	1	219384842	219384842	+	Silent	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:219384842G>A	ENST00000366928.5	+	5	533	c.486G>A	c.(484-486)caG>caA	p.Q162Q	LYPLAL1_ENST00000483635.1_3'UTR|LYPLAL1_ENST00000366927.3_Silent_p.Q146Q	NM_138794.3	NP_620149.1	Q5VWZ2	LYPL1_HUMAN	lysophospholipase-like 1	162						cytoplasm	lysophospholipase activity			large_intestine(1)|lung(5)	6				GBM - Glioblastoma multiforme(131;0.055)|all cancers(67;0.105)|OV - Ovarian serous cystadenocarcinoma(81;0.116)		AGGCTCTTCAGAAGAGTAATG	0.333000													13	99					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7724457	7724457	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:7724457T>C	ENST00000303635.7	+	9	2057	c.1850T>C	c.(1849-1851)tTc>tCc	p.F617S	CAMTA1_ENST00000439411.2_Missense_Mutation_p.F617S	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	617					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CCGAGCTTCTTCCTGCAGGAC	0.627000			T	WWTR1	epitheliod hemangioendothelioma								37	138					0	0	1	0	0
NAB1	4664	broad.mit.edu	37	2	191524148	191524148	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:191524148C>T	ENST00000337386.5	+	4	707	c.246C>T	c.(244-246)ttC>ttT	p.F82F	NAB1_ENST00000357215.5_Silent_p.F82F|NAB1_ENST00000409581.1_Silent_p.F82F|NAB1_ENST00000409641.1_Silent_p.F82F	NM_005966.3	NP_005957.2	Q13506	NAB1_HUMAN	NGFI-A binding protein 1 (EGR1 binding protein 1)	82	NCD1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(1)	7			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			CTGGGCTTTTCAATCAGCCAC	0.478000													83	68					0	0	1	0	0
LILRA6	79168	broad.mit.edu	37	19	54746124	54746124	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:54746124C>T	ENST00000440558.2	-	3	181	c.133G>A	c.(133-135)Gtg>Atg	p.V45M	LILRA6_ENST00000396365.2_Missense_Mutation_p.V45M|LILRA6_ENST00000270464.5_Missense_Mutation_p.V45M|LILRA6_ENST00000391735.3_Missense_Mutation_p.V45M|LILRA6_ENST00000245621.5_Missense_Mutation_p.V45M|LILRB3_ENST00000407860.2_Missense_Mutation_p.V45M|LILRA6_ENST00000419410.2_Missense_Mutation_p.V45M					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6											central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(20)|ovary(3)|skin(2)|urinary_tract(2)	38	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAGATGGTCACGGGGCTCCCC	0.597000													73	236					0	0	1	0	0
PLCB3	5331	broad.mit.edu	37	11	64031183	64031183	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:64031183C>T	ENST00000540288.1	+	21	2579	c.2476C>T	c.(2476-2478)Cgg>Tgg	p.R826W	PLCB3_ENST00000279230.6_Missense_Mutation_p.R826W|PLCB3_ENST00000325234.5_Missense_Mutation_p.R759W	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	826					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						CGTCTGCCTGCGGAACGAGGC	0.662000													18	109					0	0	1	0	0
KARS	3735	broad.mit.edu	37	16	75664388	75664388	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr16:75664388C>T	ENST00000319410.5	-	12	1562	c.1441G>A	c.(1441-1443)Gaa>Aaa	p.E481K	KARS_ENST00000302445.3_Missense_Mutation_p.E453K|KARS_ENST00000568378.1_Intron	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	453					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	CAAGTCACTTCCAGGAACTCC	0.438000													11	27					0	0	1	0	0
PPAN	56342	broad.mit.edu	37	19	10224864	10224864	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:10224864T>C	ENST00000556468.1	+	13	1862	c.1835T>C	c.(1834-1836)cTg>cCg	p.L612P	PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.L612P|P2RY11_ENST00000321826.4_Missense_Mutation_p.L192P|PPAN-P2RY11_ENST00000428358.1_3'UTR					peter pan homolog (Drosophila)											endometrium(3)|liver(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			ATCAAGTGTCTGGGGACAGCA	0.692000													15	45					0	0	1	0	0
AGO1	26523	broad.mit.edu	37	1	36385120	36385120	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:36385120C>T	ENST00000373204.4	+	19	2699	c.2486C>T	c.(2485-2487)tCg>tTg	p.S829L	AGO1_ENST00000373206.1_Missense_Mutation_p.S754L	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		AGCCACATATCGGGGCAGAGC	0.577000													5	18					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	192053223	192053223	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:192053223C>T	ENST00000454309.2	-	3	1166	c.341G>A	c.(340-342)cGt>cAt	p.R114H	FGF12_ENST00000445105.1_Missense_Mutation_p.R52H|FGF12_ENST00000430714.1_Missense_Mutation_p.R15H|FGF12_ENST00000264730.3_Missense_Mutation_p.R52H|FGF12_ENST00000450716.1_Missense_Mutation_p.R52H	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	114					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		GGCCACTACACGCAGGCCCAC	0.443000													57	111					0	0	1	0	0
LHX4	89884	broad.mit.edu	37	1	180243494	180243494	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:180243494C>T	ENST00000263726.2	+	6	1197	c.953C>T	c.(952-954)tCg>tTg	p.S318L	RP5-1180C10.2_ENST00000440959.2_RNA|RP5-1180C10.2_ENST00000415414.1_RNA	NM_033343.3	NP_203129.1	Q969G2	LHX4_HUMAN	LIM homeobox 4	318						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)	16						TCCTCCATATCGTCCCTGCCA	0.547000													5	228					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44652088	44652088	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr4:44652088A>C	ENST00000332990.5	-	2	118	c.102T>G	c.(100-102)gaT>gaG	p.D34E	YIPF7_ENST00000508947.1_5'UTR	NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	34						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						ATTGGTAAAAATCAGAGTCAA	0.294000													7	2					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178927980	178927980	+	Missense_Mutation	SNP	T	T	C	rs121913272		TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:178927980T>C	ENST00000263967.3	+	8	1415	c.1258T>C	c.(1258-1260)Tgt>Cgt	p.C420R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	420	C2 PI3K-type.		C -> R (in cancer; shows an increase in lipid kinase activity; may increase the affinity for lipid membranes).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.C420R(40)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TAAGGAACACTGTCCATTGGC	0.328000	C420R(CCK81_LARGE_INTESTINE)|C420R(EFM192A_BREAST)|C420R(HEC151_ENDOMETRIUM)|C420R(OVISE_OVARY)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			35	98					0	0	1	0	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													4	116					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71510131	71510131	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr4:71510131C>T	ENST00000396073.3	+	9	3269	c.2988C>T	c.(2986-2988)aaC>aaT	p.N996N	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	996					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			ATGGGAACAACATTCTGGAAC	0.423000													35	129					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157805671	157805671	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:157805671T>G	ENST00000368174.4	-	3	426	c.330A>C	c.(328-330)gaA>gaC	p.E110D		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	110	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AATCATAAACTTCTTCTTGCT	0.498000													41	174					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56425108	56425108	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr6:56425108C>T	ENST00000370754.5	-	58	14330	c.14331G>A	c.(14329-14331)caG>caA	p.Q4777Q	DST_ENST00000361203.3_Silent_p.Q4597Q|DST_ENST00000421834.2_Silent_p.Q2511Q|DST_ENST00000370769.4_Silent_p.Q4599Q|DST_ENST00000244364.6_Silent_p.Q2185Q|DST_ENST00000312431.6_3'UTR|DST_ENST00000370788.2_Silent_p.Q2511Q|DST_ENST00000446842.2_Silent_p.Q4273Q			Q03001	DYST_HUMAN	dystonin	4597					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTGTCAACATCTGTTTCCATC	0.378000													6	23					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120767204	120767204	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr7:120767204G>C	ENST00000310396.5	+	10	1662	c.1195G>C	c.(1195-1197)Gaa>Caa	p.E399Q	CPED1_ENST00000450913.2_Missense_Mutation_p.E399Q|CPED1_ENST00000423795.1_Missense_Mutation_p.E179Q	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1									p.E399*(1)									CCAAAATACAGAAGAATTCCT	0.294000													30	70					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20296121	20296121	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr14:20296121A>C	ENST00000568211.1	+	1	514	c.514A>C	c.(514-516)Aac>Cac	p.N172H	OR4N2_ENST00000315947.1_Missense_Mutation_p.N172H			Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTGTGGCCCAAACCAGCTGGA	0.522000													54	260					0	0	1	0	0
CPVL	54504	broad.mit.edu	37	7	29035451	29035451	+	Silent	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr7:29035451C>G	ENST00000409850.1	-	17	2014	c.1368G>C	c.(1366-1368)ctG>ctC	p.L456L	CPVL_ENST00000396276.3_Silent_p.L456L|CPVL_ENST00000265394.5_Silent_p.L456L			Q9H3G5	CPVL_HUMAN	carboxypeptidase, vitellogenic-like	456					proteolysis		protein binding|serine-type carboxypeptidase activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)	28						CAAAAGCTCTCAGAGGCTGGT	0.338000													23	68					0	0	1	0	0
GRIN2D	2906	broad.mit.edu	37	19	48945146	48945146	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:48945146C>T	ENST00000263269.3	+	11	2461	c.2373C>T	c.(2371-2373)atC>atT	p.I791I		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	791						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	GCTATGGCATCGCCCTGCACA	0.632000													9	64					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89431583	89431583	+	RNA	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:89431583T>C	ENST00000532352.1	+	0	1865							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						AACAGGCATGTCATCTATGCT	0.413000													68	46					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327859	57327859	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:57327859T>C	ENST00000326441.9	-	10	2314	c.1951A>G	c.(1951-1953)Aga>Gga	p.R651G	PEG3_ENST00000598410.1_Missense_Mutation_p.R527G|PEG3_ENST00000593695.1_Missense_Mutation_p.R525G|PEG3_ENST00000423103.2_Missense_Mutation_p.R651G|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	651					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GGGTTCCCTCTAGTATGGATT	0.398000													88	75					0	0	1	0	0
BIRC2	329	broad.mit.edu	37	11	102220775	102220775	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:102220775G>A	ENST00000227758.2	+	2	1589	c.190G>A	c.(190-192)Gaa>Aaa	p.E64K	BIRC2_ENST00000527910.1_3'UTR|BIRC2_ENST00000532672.1_Missense_Mutation_p.E43K|BIRC2_ENST00000530675.1_Missense_Mutation_p.E15K	NM_001166.4|NM_001256163.1	NP_001157.1|NP_001243092.1	Q13490	BIRC2_HUMAN	baculoviral IAP repeat containing 2	64					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		GCCTGTCTCAGAAAGGAGTCT	0.428000													41	78					0	0	1	0	0
EDNRB	1910	broad.mit.edu	37	13	78472336	78472336	+	Nonstop_Mutation	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr13:78472336C>G	ENST00000377211.4	-	8	1750	c.1598G>C	c.(1597-1599)tGa>tCa	p.*533S	EDNRB_ENST00000334286.5_Nonstop_Mutation_p.*443S|EDNRB_ENST00000446573.1_Intron	NM_001201397.1	NP_001188326.1	P24530	EDNRB_HUMAN	endothelin receptor type B	0					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(18)|lung(16)|skin(3)	42		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GTTCTTCTTTCAAGATGAGCT	0.323000													25	28					0	0	1	0	0
AGMAT	79814	broad.mit.edu	37	1	15909714	15909714	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:15909714G>A	ENST00000375826.3	-	2	591	c.449C>T	c.(448-450)gCa>gTa	p.A150V	DNAJC16_ENST00000483270.1_Intron	NM_024758.4	NP_079034.3	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase)	150					putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(2)|skin(1)	12		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)		ACAGCCAGCTGCTACAATTTT	0.498000													21	44					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35847020	35847020	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:35847020C>A	ENST00000314607.6	+	8	1422	c.1342C>A	c.(1342-1344)Cag>Aag	p.Q448K	ZMYM4_ENST00000373297.2_Missense_Mutation_p.Q448K	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	448					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAGCATGTGTCAGAAGAATGC	0.348000													15	33					6.72482e-11	7.41616e-11	1	1	0
OR10W1	81341	broad.mit.edu	37	11	58034866	58034866	+	Silent	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:58034866G>A	ENST00000395079.2	-	1	866	c.465C>T	c.(463-465)ttC>ttT	p.F155F		NM_207374.3	NP_997257.2	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W, member 1	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				ATGGCAGAGAGAAGATGAAGG	0.488000													5	17					0	0	1	0	0
PSPC1	55269	broad.mit.edu	37	13	20279929	20279929	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr13:20279929G>A	ENST00000338910.4	-	8	1418	c.1259C>T	c.(1258-1260)cCa>cTa	p.P420L		NM_001042414.2	NP_001035879.1	Q8WXF1	PSPC1_HUMAN	paraspeckle component 1	420	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		ACCCATCATTGGAGGAGGACC	0.458000													7	86					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140401898	140401898	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:140401898C>A	ENST00000286349.3	+	2	1127	c.936C>A	c.(934-936)ttC>ttA	p.F312L		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	312						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						TCTGCACCTTCTGCAAGTTCT	0.562000													6	53					3.59834e-05	3.77425e-05	1	1	0
LRRK2	120892	broad.mit.edu	37	12	40758785	40758785	+	Silent	SNP	T	T	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr12:40758785T>A	ENST00000298910.7	+	49	7381	c.7323T>A	c.(7321-7323)acT>acA	p.T2441T		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2441					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				ATCTTTCAACTCGTCGACTTA	0.398000											OREG0003828	type=REGULATORY REGION|Gene=LRRK2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	11	50					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537243	5537243	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:5537243T>G	ENST00000380184.1	-	1	692	c.429A>C	c.(427-429)caA>caC	p.Q143H	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	143			Q -> K (in dbSNP:rs3802978).							endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		CCACTGGAGCTTGATTCATAC	0.542000													25	59					0	0	1	0	0
TFIP11	24144	broad.mit.edu	37	22	26902830	26902830	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr22:26902830C>T	ENST00000407690.1	-	5	557	c.274G>A	c.(274-276)Gag>Aag	p.E92K	TFIP11_ENST00000407431.1_Missense_Mutation_p.E92K|TFIP11_ENST00000407148.1_Missense_Mutation_p.E92K|TFIP11_ENST00000405938.1_Missense_Mutation_p.E92K	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	92					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						AACTCTGCCTCCTCCGCTGCC	0.517000													73	42					0	0	1	0	0
ALDOA	226	broad.mit.edu	37	16	30081416	30081416	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr16:30081416C>T	ENST00000569798.1	+	8	1242	c.1065C>T	c.(1063-1065)caC>caT	p.H355H	ALDOA_ENST00000566897.1_Intron|ALDOA_ENST00000564546.1_Intron|ALDOA_ENST00000569545.1_Intron|ALDOA_ENST00000412304.2_Intron|ALDOA_ENST00000395240.3_Intron|ALDOA_ENST00000395248.1_Intron|ALDOA_ENST00000564595.2_Intron|ALDOA_ENST00000338110.5_Intron|ALDOA_ENST00000563060.2_Intron			P04075	ALDOA_HUMAN	aldolase A, fructose-bisphosphate	0					actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	17						GCCCTTCTCACTCCACCCCTC	0.622000													16	59					0	0	1	0	0
FMO4	2329	broad.mit.edu	37	1	171302029	171302029	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:171302029G>A	ENST00000367749.3	+	7	1139	c.809G>A	c.(808-810)gGa>gAa	p.G270E	FMO4_ENST00000462992.1_3'UTR	NM_002022.1	NP_002013.1	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	270					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					GAGGATTATGGATTAAGTATT	0.264000													26	36					0	0	1	0	0
ABCF1	23	broad.mit.edu	37	6	30547717	30547717	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr6:30547717G>A	ENST00000326195.8	+	7	611	c.499G>A	c.(499-501)Gag>Aag	p.E167K	ABCF1_ENST00000396515.4_Intron|ABCF1_ENST00000376545.3_Missense_Mutation_p.E167K	NM_001025091.1	NP_001020262.1	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 1	167	Glu-rich.				inflammatory response|translational initiation	nuclear envelope|nucleoplasm|polysomal ribosome	ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|skin(2)	21						GGCCGTATCTGAGGAACAGCA	0.453000													27	75					0	0	1	0	0
ERCC6L2	375748	broad.mit.edu	37	9	98775374	98775374	+	Silent	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr9:98775374G>A	ENST00000407474.3	+	4	1998	c.1485G>A	c.(1483-1485)agG>agA	p.R495R				Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	20					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding										CCTTTAAAAGGAGAGAAGAGC	0.388000													25	56					0	0	1	0	0
ROCK2	9475	broad.mit.edu	37	2	11376025	11376025	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:11376025C>T	ENST00000315872.6	-	5	974	c.526G>A	c.(526-528)Gac>Aac	p.D176N	ROCK2_ENST00000462366.1_5'UTR	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	176	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TTTACAAGGTCTCCACCAGGC	0.373000													25	58					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558642	113558642	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr7:113558642A>C	ENST00000284601.3	-	1	478	c.410T>G	c.(409-411)cTt>cGt	p.L137R		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	137	CBM21.				glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TGTAGACCCAAGAAGAGACTC	0.358000													16	164					0	0	1	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													4	43					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839544	128839544	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:128839544T>C	ENST00000310343.9	-	22	5521	c.5522A>G	c.(5521-5523)cAt>cGt	p.H1841R	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.H1492R|ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.H1492R	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1841	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GCCTCCGTGATGGTGGGCTCT	0.612000													60	46					0	0	1	0	0
TNPO1	3842	broad.mit.edu	37	5	72151642	72151642	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr5:72151642A>C	ENST00000337273.5	+	4	673	c.247A>C	c.(247-249)Aat>Cat	p.N83H	TNPO1_ENST00000513944.1_3'UTR|TNPO1_ENST00000454282.1_Intron|TNPO1_ENST00000523768.1_Intron|TNPO1_ENST00000506351.2_Missense_Mutation_p.N75H|TNPO1_ENST00000447967.2_Missense_Mutation_p.N75H	NM_002270.3	NP_002261.3	Q92973	TNPO1_HUMAN	transportin 1	83	Importin N-terminal.				interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(6)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	36		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		CTTGAAGAATAATGTGAAAGC	0.328000													13	28					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18846140	18846140	+	RNA	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr22:18846140T>C	ENST00000412938.1	+	0	3498																											TAGGGCACCTTGGACCTCTCT	0.617000													6	27					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130380668	130380668	+	Silent	SNP	T	T	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:130380668T>A	ENST00000358511.6	+	34	6049	c.6018T>A	c.(6016-6018)acT>acA	p.T2006T	COL6A6_ENST00000453409.2_Silent_p.T2006T	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	2006	Nonhelical region.|VWFA 9.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						CTTCTGTCACTGGAGACCGGG	0.507000													7	36					0	0	1	0	0
GOLGA8DP	100132979	broad.mit.edu	37	15	22709657	22709657	+	RNA	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr15:22709657C>A	ENST00000314246.8	-	0	1127																											GGACAAGCTCCTCTCCAGCTT	0.557000													51	231					2.2129e-31	2.56002e-31	1	1	0
PHF21A	51317	broad.mit.edu	37	11	45970983	45970983	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:45970983C>T	ENST00000257821.4	-	12	1820	c.1197G>A	c.(1195-1197)ccG>ccA	p.P399P	PHF21A_ENST00000418153.2_Silent_p.P398P|PHF21A_ENST00000323180.6_Silent_p.P399P|PHF21A_ENST00000527753.1_5'UTR	NM_001101802.1	NP_001095272.1	Q96BD5	PF21A_HUMAN	PHD finger protein 21A	398					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(10)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	29						CACTGTAGACCGGATTTGCTG	0.458000													21	108					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578431	7578431	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr17:7578431G>A	ENST00000420246.2	-	5	631	c.499C>T	c.(499-501)Cag>Tag	p.Q167*	TP53_ENST00000455263.2_Nonsense_Mutation_p.Q167*|TP53_ENST00000269305.4_Nonsense_Mutation_p.Q167*|TP53_ENST00000359597.4_Nonsense_Mutation_p.Q167*|TP53_ENST00000413465.2_Nonsense_Mutation_p.Q167*|TP53_ENST00000445888.2_Nonsense_Mutation_p.Q167*|TP53_ENST00000574684.1_5'UTR	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	167	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in LFS; germline mutation and in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HD (in a sporadic cancer; somatic mutation).|QH -> YL (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q167*(23)|p.0?(8)|p.Q167fs*13(3)|p.Q167fs*14(2)|p.Q167fs*3(2)|p.K164fs*3(2)|p.V157_C176del20(1)|p.Q167_H168>YL(1)|p.Q167K(1)|p.Y163fs*1(1)|p.Q167fs*12(1)|p.P151_V173del23(1)|p.Q165_M169delQSQHM(1)|p.Q167del(1)|p.S149fs*72(1)|p.A159_Q167delAMAIYKQSQ(1)|p.Q74*(1)|p.Q167E(1)|p.Q35*(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCATGTGCTGTGACTGCTTG	0.642000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			39	30					0	0	1	0	0
KLK8	11202	broad.mit.edu	37	19	51503709	51503709	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:51503709C>T	ENST00000600767.1	-	4	690	c.201G>A	c.(199-201)tgG>tgA	p.W67*	KLK8_ENST00000347619.4_Intron|KLK8_ENST00000291726.7_Nonsense_Mutation_p.W67*|KLK8_ENST00000391806.2_Nonsense_Mutation_p.W112*|KLK8_ENST00000320838.5_Intron|KLK8_ENST00000593490.1_Intron|CTB-147C22.9_ENST00000594512.1_RNA			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	67	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		CTGTAAGGACCCAGTTGCCAC	0.592000													30	172					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53644386	53644386	+	Silent	SNP	T	T	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:53644386T>A	ENST00000452676.2	-	5	2124	c.1698A>T	c.(1696-1698)ggA>ggT	p.G566G	ZNF347_ENST00000334197.7_Silent_p.G565G|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000601469.2_Silent_p.G566G	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		AAGGTTTTTCTCCAGTATGGA	0.408000													6	299					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56329372	56329372	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:56329372G>T	ENST00000443188.1	-	4	879	c.169C>A	c.(169-171)Cca>Aca	p.P57T	NLRP11_ENST00000589093.1_Missense_Mutation_p.P57T|NLRP11_ENST00000592953.1_Intron|NLRP11_ENST00000589824.2_Missense_Mutation_p.P57T|NLRP11_ENST00000360133.3_Missense_Mutation_p.P57T	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	57	DAPIN.						ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TAAGAGATTGGCAACACGTTA	0.388000													19	113					7.45023e-12	8.25471e-12	1	1	0
RANBP6	26953	broad.mit.edu	37	9	6015065	6015065	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr9:6015065G>C	ENST00000259569.5	-	1	553	c.543C>G	c.(541-543)atC>atG	p.I181M	RANBP6_ENST00000485372.1_Intron	NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	181					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ACAACCGTTTGATGATATCCA	0.433000													19	43					0	0	1	0	0
KIF2A	3796	broad.mit.edu	37	5	61659554	61659554	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr5:61659554C>A	ENST00000381103.2	+	15	1720	c.1235C>A	c.(1234-1236)tCa>tAa	p.S412*	KIF2A_ENST00000509663.2_Intron|KIF2A_ENST00000401507.3_Nonsense_Mutation_p.S432*|KIF2A_ENST00000407818.3_Nonsense_Mutation_p.S432*|KIF2A_ENST00000506857.1_Nonsense_Mutation_p.S386*	NM_001243952.1	NP_001230881.1	O00139	KIF2A_HUMAN	kinesin heavy chain member 2A	432	Kinesin-motor.				blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	15		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		AATGCACATTCATCTCGGAGC	0.353000													38	34					2.54354e-34	2.95702e-34	1	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144930711	144930711	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:144930711C>G	ENST00000529945.1	-	1	1437	c.998G>C	c.(997-999)aGt>aCt	p.S333T	PDE4DIP_ENST00000369349.3_Intron|PDE4DIP_ENST00000369351.3_Intron|PDE4DIP_ENST00000369356.4_Intron|PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.S333T|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000369354.3_Intron|PDE4DIP_ENST00000479408.2_Intron|PDE4DIP_ENST00000530740.1_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GAAACCGGAACTAACTCCATC	0.527000			T	PDGFRB	MPD								90	177					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183474315	183474315	+	Splice_Site	SNP	G	G	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:183474315G>T	ENST00000305135.5	+	12	1585		c.e12-1			NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2						histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TAATTAATAAGGTTCCCCAAT	0.443000													18	199					6.94344e-10	7.58635e-10	1	1	0
RTKN	6242	broad.mit.edu	37	2	74656049	74656049	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:74656049A>C	ENST00000305557.5	-	8	1322	c.737T>G	c.(736-738)tTg>tGg	p.L246W	RTKN_ENST00000233330.6_Missense_Mutation_p.L209W|RTKN_ENST00000272430.5_Missense_Mutation_p.L259W	NM_033046.2	NP_149035.1	Q9BST9	RTKN_HUMAN	rhotekin	259					apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			endometrium(3)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	16						GGTGTGAGCCAAGAGGTGGTA	0.567000													10	68					0	0	1	0	0
UBA1	7317	broad.mit.edu	37	X	47058499	47058499	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chrX:47058499G>A	ENST00000335972.6	+	3	353	c.170G>A	c.(169-171)cGg>cAg	p.R57Q	UBA1_ENST00000377351.4_Missense_Mutation_p.R57Q	NM_003334.3	NP_003325.2	P22314	UBA1_HUMAN	ubiquitin-like modifier activating enzyme 1	57					cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CTTTACTCCCGGCAGCTGTAA	0.557000													24	45					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108366924	108366924	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:108366924G>A	ENST00000361582.3	+	16	2157	c.1927G>A	c.(1927-1929)Gaa>Aaa	p.E643K	DZIP3_ENST00000463306.1_Missense_Mutation_p.E643K	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	643					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						AATACCCAGTGAATCTTCAAC	0.358000													30	91					0	0	1	0	0
SMYD3	64754	broad.mit.edu	37	1	246027161	246027161	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:246027161G>T	ENST00000490107.1	-	9	880	c.664C>A	c.(664-666)Caa>Aaa	p.Q222K	SMYD3_ENST00000388985.4_Missense_Mutation_p.Q281K|SMYD3_ENST00000366517.1_5'UTR|SMYD3_ENST00000541742.1_Missense_Mutation_p.Q222K	NM_001167740.1	NP_001161212.1	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	281	SET.					cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			breast(3)|large_intestine(5)|lung(8)|skin(1)	17	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		TTCCATACTTGCTCATCACCA	0.428000													7	44					3.09899e-07	3.33955e-07	1	1	0
NXF4	55999	broad.mit.edu	37	X	101805040	101805040	+	RNA	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chrX:101805040G>A	ENST00000360035.2	+	0	148					NR_002216.1															endometrium(2)|lung(8)	10						GGTTAAGGGGGATCCTGAGCA	0.537000													42	54					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62631033	62631033	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr20:62631033C>T	ENST00000535781.1	+	8	1055	c.944C>T	c.(943-945)tCa>tTa	p.S315L	ZNF512B_ENST00000450537.1_Intron|ZNF512B_ENST00000217130.3_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	315					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					TGGATTGCATCAGCCCGCCTG	0.562000													17	60					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16284174	16284174	+	Silent	SNP	G	G	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr16:16284174G>T	ENST00000205557.7	-	12	1511	c.1482C>A	c.(1480-1482)atC>atA	p.I494I	ABCC6_ENST00000574094.1_5'UTR	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	494	ABC transmembrane type-1 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		AGTTCCTGAGGATAGAGCTGG	0.582000													67	56					1.32218e-49	1.54472e-49	1	1	0
MEN1	4221	broad.mit.edu	37	11	64572247	64572247	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:64572247C>T	ENST00000337652.1	-	10	1910	c.1407G>A	c.(1405-1407)gcG>gcA	p.A469A	MEN1_ENST00000394374.2_Silent_p.A469A|MEN1_ENST00000394376.1_Silent_p.A469A|MEN1_ENST00000315422.4_Silent_p.A464A|MEN1_ENST00000312049.6_Silent_p.A464A|MEN1_ENST00000443283.1_Silent_p.A469A|MEN1_ENST00000478548.1_5'UTR|MEN1_ENST00000377316.2_Silent_p.A409A|MEN1_ENST00000377321.1_Silent_p.A429A|MEN1_ENST00000377313.1_Silent_p.A469A|MEN1_ENST00000377326.3_Silent_p.A464A	NM_130803.2	NP_570715.1	O00255	MEN1_HUMAN	multiple endocrine neoplasia I	469					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			NS(7)|adrenal_gland(5)|breast(2)|central_nervous_system(5)|endometrium(1)|gastrointestinal_tract_(site_indeterminate)(15)|large_intestine(2)|lung(21)|ovary(1)|pancreas(64)|parathyroid(181)|pituitary(7)|prostate(4)|retroperitoneum(1)|skin(1)|small_intestine(13)|soft_tissue(4)|stomach(1)|thymus(2)	337						CGGCCTCGGCCGCCTCGGCCT	0.726000			"""D, Mis, N, F, S"""		"""parathyroid tumors, Pancreatic neuroendocrine tumors"""	"""parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid"""			Multiple Endocrine Neoplasia, type 1;Hyperparathyroidism, Familial Isolated				12	55					0	0	1	0	0
ATP5J	522	broad.mit.edu	37	21	27097603	27097603	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr21:27097603G>C	ENST00000400093.3	-	3	914	c.223C>G	c.(223-225)Ctt>Gtt	p.L75V	ATP5J_ENST00000400094.1_Missense_Mutation_p.L75V|ATP5J_ENST00000457143.2_Missense_Mutation_p.L83V|ATP5J_ENST00000284971.3_Missense_Mutation_p.L75V|ATP5J_ENST00000400087.3_Missense_Mutation_p.L75V|ATP5J_ENST00000400099.1_Missense_Mutation_p.L75V|ATP5J_ENST00000400090.3_Missense_Mutation_p.L75V	NM_001003701.1|NM_001003703.1|NM_001685.4	NP_001003701.1|NP_001003703.1|NP_001676.2	P18859	ATP5J_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6	75					ATP catabolic process|respiratory electron transport chain		hydrogen ion transmembrane transporter activity			cervix(1)|endometrium(1)|lung(1)|pancreas(1)	4						AGCTTAAAAAGCTCCCTCTCC	0.373000													13	35					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9476521	9476521	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:9476521G>A	ENST00000402466.1	+	6	778	c.10G>A	c.(10-12)Ggg>Agg	p.G4R	SETD5_ENST00000402198.1_Missense_Mutation_p.G115R|SETD5_ENST00000407969.1_Missense_Mutation_p.G134R|SETD5_ENST00000406341.1_Missense_Mutation_p.G115R|SETD5_ENST00000302463.6_Missense_Mutation_p.G4R			Q9C0A6	SETD5_HUMAN	SET domain containing 5	115										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AATGAGCAGGGGGAAGGTTAT	0.443000													5	34					0	0	1	0	0
IGKV1-5	28299	broad.mit.edu	37	2	89247307	89247307	+	RNA	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:89247307C>G	ENST00000496168.1	-	0	168																											TGTGTCCTGACTGGGTCTGAC	0.562000													5	160					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121008505	121008505	+	Missense_Mutation	SNP	G	G	A	rs144844263		TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:121008505G>A	ENST00000392793.1	+	11	3588	c.3317G>A	c.(3316-3318)gGc>gAc	p.G1106D	TECTA_ENST00000264037.2_Missense_Mutation_p.G1106D			O75443	TECTA_HUMAN	tectorin alpha	1106	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TCAGGCTACGGCCACTACCTC	0.582000													27	28					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10116617	10116617	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:10116617C>T	ENST00000264828.3	-	3	377	c.292G>A	c.(292-294)Gga>Aga	p.G98R		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	98	TSP N-terminal.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GCTGGCTGTCCCCGCAAGGTG	0.617000													29	40					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160261152	160261152	+	Silent	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:160261152G>C	ENST00000241704.7	-	31	3622	c.3393C>G	c.(3391-3393)ctC>ctG	p.L1131L	COPA_ENST00000368069.3_Silent_p.L1140L	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	1131					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GCTTGGGCCCGAGTTCTAGTA	0.547000											OREG0013929	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	81					0	0	1	0	0
UBA1	7317	broad.mit.edu	37	X	47058202	47058202	+	Splice_Site	SNP	A	A	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chrX:47058202A>T	ENST00000335972.6	+	2	184	c.0_splice	c.e2-1	p.M1_splice	UBA1_ENST00000377351.4_Splice_Site_p.M1_splice	NM_003334.3	NP_003325.2	P22314	UBA1_HUMAN	ubiquitin-like modifier activating enzyme 1	1					cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TTTCCTCCAGATGTCCAGCTC	0.542000													9	21					0	0	1	0	0
PSMB9	5698	broad.mit.edu	37	6	32825906	32825906	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr6:32825906G>T	ENST00000395330.1	+	4	464	c.316G>T	c.(316-318)Ggt>Tgt	p.G106C	PSMB9_ENST00000374859.2_Missense_Mutation_p.G129C|PSMB9_ENST00000453265.2_Missense_Mutation_p.G85C			P28065	PSB9_HUMAN	proteasome (prosome, macropain) subunit, beta type, 9	129					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			large_intestine(4)|lung(4)|skin(1)	9						ACGTGAAGGAGGTCAGGTGAG	0.488000													14	54					1.3612e-06	1.45359e-06	1	1	0
MPHOSPH9	10198	broad.mit.edu	37	12	123679044	123679044	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr12:123679044G>C	ENST00000606320.1	-	13	2336	c.2130C>G	c.(2128-2130)atC>atG	p.I710M	MPHOSPH9_ENST00000541076.2_Missense_Mutation_p.I680M|MPHOSPH9_ENST00000302349.5_Missense_Mutation_p.I558M|MPHOSPH9_ENST00000392425.3_Missense_Mutation_p.I558M			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	558					M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		TTAGTCGAATGATGGTATTGT	0.358000													24	13					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85722859	85722859	+	Silent	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr4:85722859G>A	ENST00000322366.6	-	17	3173	c.2766C>T	c.(2764-2766)ccC>ccT	p.P922P	WDFY3_ENST00000295888.4_Silent_p.P922P			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	922						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCCGCTGCAGGGGCGGGTGCA	0.502000													13	44					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	56138547	56138547	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr10:56138547T>C	ENST00000373965.2	-	4	707	c.313A>G	c.(313-315)Aga>Gga	p.R105G	PCDH15_ENST00000414778.1_Missense_Mutation_p.R110G|PCDH15_ENST00000395430.1_Missense_Mutation_p.R105G|PCDH15_ENST00000395442.1_Missense_Mutation_p.R105G|PCDH15_ENST00000395433.1_Missense_Mutation_p.R83G|PCDH15_ENST00000373955.1_Missense_Mutation_p.R105G|PCDH15_ENST00000361849.3_Missense_Mutation_p.R105G|PCDH15_ENST00000395438.1_Missense_Mutation_p.R105G|PCDH15_ENST00000395440.1_Missense_Mutation_p.R105G|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395445.1_Missense_Mutation_p.R105G|PCDH15_ENST00000437009.1_Missense_Mutation_p.R105G|PCDH15_ENST00000395446.1_Missense_Mutation_p.R105G|PCDH15_ENST00000395432.2_Missense_Mutation_p.R105G|PCDH15_ENST00000320301.6_Missense_Mutation_p.R105G|PCDH15_ENST00000373957.3_Missense_Mutation_p.R83G	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	105	Cadherin 1.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CTAACATCTCTATCCAGAACT	0.313000										HNSCC(58;0.16)			10	46					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62294723	62294723	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:62294723G>A	ENST00000378024.4	-	5	7440	c.7166C>T	c.(7165-7167)cCa>cTa	p.P2389L	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2389					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				ATCGAGGTCTGGCATAGAGAT	0.478000													55	58					0	0	1	0	0
TNFSF13B	10673	broad.mit.edu	37	13	108955645	108955645	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr13:108955645A>T	ENST00000375887.4	+	4	704	c.526A>T	c.(526-528)Agt>Tgt	p.S176C	TNFSF13B_ENST00000479435.1_3'UTR|TNFSF13B_ENST00000430559.1_Missense_Mutation_p.S157C|TNFSF13B_ENST00000542136.1_Intron	NM_006573.4	NP_006564.1	Q9Y275	TN13B_HUMAN	tumor necrosis factor (ligand) superfamily, member 13b	176					cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding			large_intestine(1)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			TAAAAGGGGAAGTGCCCTAGA	0.348000													24	25					0	0	1	0	0
EPRS	2058	broad.mit.edu	37	1	220179656	220179656	+	Splice_Site	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:220179656C>G	ENST00000366923.3	-	15	2012		c.e15-1		EPRS_ENST00000464052.1_Splice_Site	NM_004446.2	NP_004437.2	P07814	SYEP_HUMAN	glutamyl-prolyl-tRNA synthetase						glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			breast(2)|endometrium(11)|kidney(2)|large_intestine(13)|lung(24)|ovary(1)|prostate(3)|skin(2)|stomach(2)|urinary_tract(3)	63				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	ATCTGCATTTCTAGATATAAG	0.264000													20	42					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204956668	204956668	+	Splice_Site	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:204956668T>C	ENST00000367172.4	+	24	3242	c.2914_splice	c.e24+1	p.F972_splice	NFASC_ENST00000339876.6_Splice_Site_p.F865_splice|NFASC_ENST00000404076.1_Splice_Site_p.F951_splice|NFASC_ENST00000338515.6_Splice_Site_p.F972_splice|NFASC_ENST00000495396.1_3'UTR|NFASC_ENST00000539706.1_Splice_Site_p.F968_splice|NFASC_ENST00000513543.1_Splice_Site_p.F968_splice|NFASC_ENST00000404907.1_Splice_Site_p.F968_splice|NFASC_ENST00000360049.4_Splice_Site_p.F968_splice|NFASC_ENST00000367171.4_Splice_Site_p.F957_splice|NFASC_ENST00000367170.4_Splice_Site_p.F972_splice|NFASC_ENST00000401399.1_Splice_Site_p.F865_splice|NFASC_ENST00000367169.4_Splice_Site_p.F865_splice|NFASC_ENST00000338586.6_Splice_Site_p.F972_splice			O94856	NFASC_HUMAN	neurofascin	972	Fibronectin type-III 4.			F -> V (in Ref. 3; AK127424).	axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			ATATGTGGCCTGTACGTTCTG	0.493000													44	109					0	0	1	0	0
STEAP1	26872	broad.mit.edu	37	7	89790374	89790374	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr7:89790374A>G	ENST00000297205.2	+	3	540	c.340A>G	c.(340-342)Atc>Gtc	p.I114V	STEAP2-AS1_ENST00000478318.2_RNA	NM_012449.2	NP_036581.1	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the prostate 1	114					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			kidney(2)|large_intestine(3)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	14	all_hematologic(106;0.112)					AATCCTGGTCATCAACAAAGT	0.388000													17	144					0	0	1	0	0
TRAV21	28662	broad.mit.edu	37	14	22521230	22521230	+	RNA	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr14:22521230C>G	ENST00000390449.3	+	0	258																											CTTAATGCCTCGCTGGATAAA	0.488000													20	24					0	0	1	0	0
ZNF280D	54816	broad.mit.edu	37	15	56923975	56923975	+	Silent	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr15:56923975T>C	ENST00000559237.1	-	21	3305	c.2622A>G	c.(2620-2622)gcA>gcG	p.A874A	ZNF280D_ENST00000267807.7_Silent_p.A887A	NM_001002843.1	NP_001002843.1	Q6N043	Z280D_HUMAN	zinc finger protein 280D	887					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(4)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	30				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		CATTATCTGATGCTAATCGCA	0.353000													47	35					0	0	1	0	0
AGO1	26523	broad.mit.edu	37	1	36359740	36359740	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:36359740C>T	ENST00000373204.4	+	6	965	c.752C>T	c.(751-753)tCt>tTt	p.S251F	AGO1_ENST00000373206.1_Missense_Mutation_p.S176F	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		CTCACGGACTCTCAGCGCGTT	0.547000													18	48					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45358032	45358032	+	Silent	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr20:45358032G>C	ENST00000359271.2	+	4	1702	c.1452G>C	c.(1450-1452)ctG>ctC	p.L484L		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	484						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				TCTACGGACTGACCGCTGTCC	0.582000													25	61					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90437619	90437619	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr6:90437619T>A	ENST00000369393.3	-	37	5520	c.5405A>T	c.(5404-5406)gAg>gTg	p.E1802V	MDN1_ENST00000428876.1_Missense_Mutation_p.E1802V			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1802					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CCAGGCAAACTCTCCTCCCTT	0.507000													37	45					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1264665	1264665	+	Silent	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:1264665C>A	ENST00000447027.1	+	31	6622	c.6564C>A	c.(6562-6564)acC>acA	p.T2188T	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Silent_p.T2185T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2185	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TAGGGACCACCCACACACCCC	0.672000													4	20					0.00909568	0.00921279	1	1	0
FNDC1	84624	broad.mit.edu	37	6	159655440	159655440	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr6:159655440G>A	ENST00000297267.9	+	11	4096	c.3896G>A	c.(3895-3897)cGc>cAc	p.R1299H	FNDC1_ENST00000340366.6_Missense_Mutation_p.R1236H	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1299						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CTGTCCTTGCGCCAGAGGATG	0.602000													11	33					0	0	1	0	0
ATRN	8455	broad.mit.edu	37	20	3557521	3557521	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr20:3557521T>C	ENST00000262919.5	+	14	2298	c.2230T>C	c.(2230-2232)Tat>Cat	p.Y744H	ATRN_ENST00000446916.2_Missense_Mutation_p.Y744H	NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	744	PSI 1.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						CATTTTTAGGTATGAGAATTG	0.458000													27	64					0	0	1	0	0
P4HA1	5033	broad.mit.edu	37	10	74813153	74813153	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr10:74813153T>C	ENST00000412021.2	-	7	992	c.659A>G	c.(658-660)gAc>gGc	p.D220G	P4HA1_ENST00000263556.3_Missense_Mutation_p.D220G|P4HA1_ENST00000440381.1_Missense_Mutation_p.D220G|P4HA1_ENST00000373008.2_Missense_Mutation_p.D220G|P4HA1_ENST00000307116.2_Missense_Mutation_p.D220G|P4HA1_ENST00000394890.2_Missense_Mutation_p.D220G	NM_001142595.1	NP_001136067.1	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha polypeptide I	220						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CTTATCCAGGTCTCCCTGCTG	0.393000													15	62					0	0	1	0	0
FANCB	2187	broad.mit.edu	37	X	14882892	14882892	+	Silent	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chrX:14882892G>A	ENST00000398334.1	-	3	1008	c.741C>T	c.(739-741)atC>atT	p.I247I	FANCB_ENST00000324138.3_Silent_p.I247I	NM_001018113.1	NP_001018123.1	Q8NB91	FANCB_HUMAN	Fanconi anemia, complementation group B	247					DNA repair	nucleoplasm				NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24	Hepatocellular(33;0.183)					GGTTTTTGATGATCTCAGTTG	0.353000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				17	16					0	0	1	0	0
LONP1	9361	broad.mit.edu	37	19	5719905	5719905	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:5719905G>A	ENST00000360614.3	-	1	396	c.239C>T	c.(238-240)tCg>tTg	p.S80L	LONP1_ENST00000540670.2_Intron|LONP1_ENST00000585374.1_Intron|LONP1_ENST00000590511.1_5'UTR|LONP1_ENST00000593119.1_Intron	NM_004793.2	NP_004784.2	P36776	LONM_HUMAN	lon peptidase 1, mitochondrial	80					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CTCGCCCCCCGAGAATGCGCC	0.761000													3	11					0	0	1	0	0
C1QL2	165257	broad.mit.edu	37	2	119915201	119915201	+	Silent	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:119915201G>A	ENST00000272520.3	-	1	1264	c.645C>T	c.(643-645)gaC>gaT	p.D215D		NM_182528.3	NP_872334.2	Q7Z5L3	C1QL2_HUMAN	complement component 1, q subcomponent-like 2	215	C1q.					collagen				NS(1)|endometrium(1)|large_intestine(3)|pancreas(1)|prostate(1)	7						TGCTGGTGCCGTCGCCGCCGC	0.642000										HNSCC(49;0.14)			25	47					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271571	22271571	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:22271571G>C	ENST00000594947.1	+	4	1163	c.1019G>C	c.(1018-1020)gGa>gCa	p.G340A		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G340A(1)		haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATTCATACTGGAGAGAAACCC	0.403000													16	70					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207176200	207176200	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:207176200G>T	ENST00000374423.3	+	5	7334	c.6948G>T	c.(6946-6948)caG>caT	p.Q2316H		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2316							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						ATGGCCGACAGAAAGGTCCTT	0.493000													8	12					2.62144e-13	2.91821e-13	1	1	0
LRRC10	376132	broad.mit.edu	37	12	70004425	70004425	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr12:70004425T>C	ENST00000361484.3	-	1	517	c.194A>G	c.(193-195)aAt>aGt	p.N65S		NM_201550.2	NP_963844.2	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	65						nucleus				large_intestine(2)|lung(6)	8	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AGGCAGGCTATTGAGGTGGTT	0.572000													8	41					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141110618	141110618	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:141110618C>G	ENST00000389484.3	-	76	12525	c.11554G>C	c.(11554-11556)Ggc>Cgc	p.G3852R		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3852	EGF-like 9.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAACATGTGCCAAACACCAAA	0.363000										TSP Lung(27;0.18)			34	71					0	0	1	0	0
SLC27A4	10999	broad.mit.edu	37	9	131122696	131122696	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr9:131122696G>A	ENST00000300456.3	+	13	1975	c.1858G>A	c.(1858-1860)Gcc>Acc	p.A620T	SLC27A4_ENST00000372870.1_Missense_Mutation_p.A214T	NM_005094.3	NP_005085.2	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid transporter), member 4	620					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding			autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						CTATCTAGATGCCCAGAAGGG	0.602000													32	80					0	0	1	0	0
HS2ST1	9653	broad.mit.edu	37	1	87599295	87599295	+	Splice_Site	SNP	A	A	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:87599295A>G	ENST00000356813.4	+	7	766		c.e7-1		RP5-1052I5.1_ENST00000484933.2_lincRNA|RP5-1052I5.2_ENST00000370548.2_Splice_Site			Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1							Golgi membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)	9		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		CTTCCTTTCCAGCACCAGATA	0.507000													5	15					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69027997	69027997	+	Silent	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr8:69027997T>C	ENST00000288368.4	+	26	3433	c.3156T>C	c.(3154-3156)tcT>tcC	p.S1052S		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1052					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GCCTTCTGTCTTCAATAACAT	0.333000													10	30					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180634263	180634263	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:180634263C>A	ENST00000410066.1	-	3	823	c.220G>T	c.(220-222)Gcc>Tcc	p.A74S		NM_152520.4	NP_689733.3	Q569K4	Z385B_HUMAN	zinc finger protein 385B	74						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			CTGGCCTGGGCGGGTGGTGGG	0.622000													19	69					1.33834e-09	1.45552e-09	1	1	0
SRRT	51593	broad.mit.edu	37	7	100478967	100478967	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr7:100478967C>T	ENST00000388793.4	+	3	404	c.184C>T	c.(184-186)Cgg>Tgg	p.R62W	SRRT_ENST00000457580.2_Missense_Mutation_p.R62W|SRRT_ENST00000432932.1_Missense_Mutation_p.R62W|SRRT_ENST00000347433.4_Missense_Mutation_p.R62W	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	62	Arg-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						TGACCGGAATCGGCGAGAGCG	0.587000													53	133					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195400841	195400841	+	RNA	SNP	C	C	A	rs7615369	by1000genomes	TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:195400841C>A	ENST00000445430.1	+	0	1437																											CTGAGCATCGCAGAGTCGTGC	0.552000													3	28					6.40141e-05	6.65521e-05	1	1	0
FAM135B	51059	broad.mit.edu	37	8	139165072	139165072	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr8:139165072G>A	ENST00000395297.1	-	13	1816	c.1646C>T	c.(1645-1647)cCa>cTa	p.P549L		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	549										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGTCAGCACTGGGGCCTGTCC	0.507000										HNSCC(54;0.14)			44	92					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54407937	54407937	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:54407937G>A	ENST00000263431.3	+	16	1987	c.1705G>A	c.(1705-1707)Gaa>Aaa	p.E569K	PRKCG_ENST00000540413.1_Missense_Mutation_p.E569K|PRKCG_ENST00000542049.1_Intron	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	569	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		GGCCATCATGGAACAAACTGT	0.592000													13	40					0	0	1	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32915726	32915726	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr15:32915726C>A	ENST00000361627.3	+	3	956	c.234C>A	c.(232-234)gaC>gaA	p.D78E	ARHGAP11A_ENST00000567348.1_Missense_Mutation_p.D78E|ARHGAP11A_ENST00000565905.1_5'UTR|ARHGAP11A_ENST00000543522.1_5'UTR|ARHGAP11A_ENST00000563864.1_Missense_Mutation_p.D78E	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	78	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity	p.D78E(2)		breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		CTTTAGAAGACCATATTCATA	0.373000													4	58					0.00024832	0.000255911	1	1	0
LPPR2	64748	broad.mit.edu	37	19	11470612	11470612	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:11470612G>A	ENST00000251473.5	+	5	747	c.371G>A	c.(370-372)cGg>cAg	p.R124Q	DKFZP761J1410_ENST00000591608.1_Missense_Mutation_p.R99Q	NM_001170635.1|NM_022737.2	NP_001164106.1|NP_073574.2																					CCCCCAGTGCGGAGGCTGGTC	0.632000													9	26					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25152630	25152630	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr22:25152630C>T	ENST00000332271.5	-	5	814	c.398G>A	c.(397-399)cGa>cAa	p.R133Q	PIWIL3_ENST00000533313.1_Missense_Mutation_p.R24Q|PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.R24Q	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	133					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						AGATATCACTCGGAAGTGGTT	0.418000													8	37					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187159417	187159417	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr4:187159417T>C	ENST00000264690.6	+	6	683	c.496T>C	c.(496-498)Tgc>Cgc	p.C166R	KLKB1_ENST00000513864.1_Missense_Mutation_p.C166R	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	166	Apple 2.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		CAGGAACAATTGCCTATTAAA	0.453000													6	42					0	0	1	0	0
CCL4	6351	broad.mit.edu	37	17	34431941	34431941	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr17:34431941G>A	ENST00000250151.4	+	2	413	c.97G>A	c.(97-99)Gcc>Acc	p.A33T	CCL4_ENST00000394495.1_Intron	NM_002984.2	NP_002975.1	P13236	CCL4_HUMAN	chemokine (C-C motif) ligand 4	33					cell adhesion|cell-cell signaling|cellular component movement|chemotaxis|establishment or maintenance of cell polarity|immune response|inflammatory response|response to virus|viral genome replication	extracellular space	chemokine activity|receptor signaling protein tyrosine kinase activity			endometrium(1)|large_intestine(1)|lung(2)	4		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCCTCCCACCGCCTGCTGCTT	0.502000													27	8					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72189919	72189919	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr15:72189919G>A	ENST00000356056.5	-	25	5397	c.4925C>T	c.(4924-4926)tCa>tTa	p.S1642L	MYO9A_ENST00000564571.1_Missense_Mutation_p.S1642L|MYO9A_ENST00000424560.1_Missense_Mutation_p.S1642L|MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000444904.1_Missense_Mutation_p.S1623L|MYO9A_ENST00000566885.1_Missense_Mutation_p.S1262L	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	1642	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TTCTCTTTTTGAAATGCGATT	0.438000													24	72					0	0	1	0	0
ZFP41	286128	broad.mit.edu	37	8	144332575	144332575	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr8:144332575C>T	ENST00000330701.4	+	2	931	c.562C>T	c.(562-564)Cgc>Tgc	p.R188C	ZFP41_ENST00000522452.1_Missense_Mutation_p.R188C|ZFP41_ENST00000520584.1_Missense_Mutation_p.R188C	NM_173832.3	NP_776193.1	Q8N8Y5	ZFP41_HUMAN	ZFP41 zinc finger protein	188					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|lung(4)|ovary(1)	8	all_cancers(97;1.01e-10)|all_epithelial(106;4.6e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CTGTCTCATCCGCCATCAGAA	0.637000													36	155					0	0	1	0	0
SEC14L5	9717	broad.mit.edu	37	16	5057406	5057406	+	Silent	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr16:5057406G>A	ENST00000251170.7	+	13	1671	c.1491G>A	c.(1489-1491)gaG>gaA	p.E497E		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	497						integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						TGACAGAAGAGGAGCAGGAGC	0.637000													33	26					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70225980	70225980	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:70225980C>T	ENST00000310961.5	+	4	526	c.108C>T	c.(106-108)caC>caT	p.H36H	LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000370958.1_Silent_p.H69H|LRRC7_ENST00000035383.5_Silent_p.H31H			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	31						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						ATTACTCCCACTGCAGTCTTC	0.458000													11	41					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144931010	144931010	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:144931010C>A	ENST00000529945.1	-	1	1138	c.699G>T	c.(697-699)atG>atT	p.M233I	PDE4DIP_ENST00000369349.3_Intron|PDE4DIP_ENST00000369351.3_Intron|PDE4DIP_ENST00000369356.4_Intron|PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.M233I|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000369354.3_Intron|PDE4DIP_ENST00000479408.2_Intron|PDE4DIP_ENST00000530740.1_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCTCTTCCTCCATGCTTTCTC	0.542000			T	PDGFRB	MPD								58	106					1.78197e-24	2.05143e-24	1	1	0
TMEM63A	9725	broad.mit.edu	37	1	226036232	226036232	+	Silent	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:226036232T>C	ENST00000366835.3	-	23	2481	c.2211A>G	c.(2209-2211)aaA>aaG	p.K737K		NM_014698.2	NP_055513.2	O94886	TM63A_HUMAN	transmembrane protein 63A	737						integral to membrane|lysosomal membrane	nucleotide binding			breast(2)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24	Breast(184;0.197)					CCTCACTTCCTTTGTCACTTG	0.483000													24	28					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23328771	23328771	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:23328771G>C	ENST00000597761.2	+	4	1124	c.925G>C	c.(925-927)Gag>Cag	p.E309Q		NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						TCATACTAAAGAGCAACCATA	0.348000													13	21					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30349804	30349804	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr18:30349804C>A	ENST00000359358.4	-	2	1189	c.751G>T	c.(751-753)Gag>Tag	p.E251*	AC012123.1_ENST00000426194.1_Nonsense_Mutation_p.S11*|KLHL14_ENST00000358095.4_Nonsense_Mutation_p.E251*	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	251	BACK.					cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						ATGCGGGTCTCGCGGTCGTGC	0.672000													7	48					0.0381472	0.0383096	1	1	0
RASGRP2	10235	broad.mit.edu	37	11	64496373	64496373	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:64496373G>A	ENST00000377494.1	-	14	2655	c.1733C>T	c.(1732-1734)tCt>tTt	p.S578F	RASGRP2_ENST00000354024.3_Missense_Mutation_p.S578F|RASGRP2_ENST00000377497.3_Missense_Mutation_p.S578F|RASGRP2_ENST00000394432.3_Missense_Mutation_p.S578F			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	578					platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GCGGGGCAGAGAGAAGCTGAA	0.642000													5	32					0	0	1	0	0
EMX2	2018	broad.mit.edu	37	10	119307725	119307725	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr10:119307725C>T	ENST00000553456.3	+	3	1565	c.741C>T	c.(739-741)gaC>gaT	p.D247D	EMX2_ENST00000546446.1_3'UTR|EMX2_ENST00000442245.4_3'UTR	NM_004098.3	NP_004089.1	Q04743	EMX2_HUMAN	empty spiracles homeobox 2	247						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|prostate(2)	12		Colorectal(252;0.109)|Lung NSC(174;0.179)|all_lung(145;0.22)		all cancers(201;0.0133)		AGGAAATAGACGTGACCTCAG	0.468000													12	6					0	0	1	0	0
UFL1	23376	broad.mit.edu	37	6	96971131	96971131	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr6:96971131A>G	ENST00000369278.4	+	2	253	c.187A>G	c.(187-189)Agt>Ggt	p.S63G		NM_015323.4	NP_056138.1	O94874	UFL1_HUMAN	UFM1-specific ligase 1	63	Required for E3 UFM1-protein ligase activity.				negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity										AGCCCAAATTAGTAAAGAAAT	0.358000													27	93					0	0	1	0	0
SMURF1	57154	broad.mit.edu	37	7	98649869	98649869	+	Missense_Mutation	SNP	C	C	T	rs148949544		TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr7:98649869C>T	ENST00000361125.1	-	7	999	c.680G>A	c.(679-681)cGa>cAa	p.R227Q	SMURF1_ENST00000480055.1_5'UTR|SMURF1_ENST00000361368.2_Missense_Mutation_p.R227Q	NM_020429.2	NP_065162.1	Q9HCE7	SMUF1_HUMAN	SMAD specific E3 ubiquitin protein ligase 1	227					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|urinary_tract(1)	25	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			GCCGTGTGGTCGGTTCTGGGG	0.557000													5	216					0	0	1	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122349000	122349000	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr10:122349000G>A	ENST00000398250.1	+	7	1154	c.802G>A	c.(802-804)Gaa>Aaa	p.E268K	PPAPDC1A_ENST00000369073.3_Missense_Mutation_p.E258K|PPAPDC1A_ENST00000398248.1_3'UTR|PPAPDC1A_ENST00000439221.1_Missense_Mutation_p.E205K	NM_001030059.1	NP_001025230.1	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain containing 1A	268					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	20		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		GGGGATCACCGAAGGCCCGGT	0.552000													10	30					0	0	1	0	0
CLIC6	54102	broad.mit.edu	37	21	36081793	36081793	+	Missense_Mutation	SNP	C	C	T	rs141470374		TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr21:36081793C>T	ENST00000360731.3	+	6	1910	c.1910C>T	c.(1909-1911)aCg>aTg	p.T637M	CLIC6_ENST00000349499.2_Missense_Mutation_p.T619M			Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	637	GST C-terminal.					chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19						GACGAGCTGACGCTGGCTGAC	0.478000													18	46					0	0	1	0	0
R3HCC1L	27291	broad.mit.edu	37	10	99968590	99968590	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr10:99968590G>A	ENST00000298999.3	+	5	1022	c.719G>A	c.(718-720)aGc>aAc	p.S240N	R3HCC1L_ENST00000314594.5_5'UTR|R3HCC1L_ENST00000370584.3_Missense_Mutation_p.S240N|R3HCC1L_ENST00000370586.2_Intron	NM_014472.4	NP_055287.4			R3H domain and coiled-coil containing 1-like																		ATAAAACTAAGCTCTGATTCT	0.378000													18	47					0	0	1	0	0
LZTR1	8216	broad.mit.edu	37	22	21349209	21349209	+	Silent	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr22:21349209C>A	ENST00000215739.8	+	16	2195	c.1836C>A	c.(1834-1836)atC>atA	p.I612I	LZTR1_ENST00000389355.3_Silent_p.I593I|LZTR1_ENST00000479606.1_3'UTR	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	612					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			ACCAGGTGATCATGATGAAGG	0.617000													19	124					3.99206e-14	4.46505e-14	1	1	0
ATP5J	522	broad.mit.edu	37	21	27097592	27097592	+	Silent	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr21:27097592G>C	ENST00000400093.3	-	3	925	c.234C>G	c.(232-234)ctC>ctG	p.L78L	ATP5J_ENST00000400094.1_Silent_p.L78L|ATP5J_ENST00000457143.2_Silent_p.L86L|ATP5J_ENST00000284971.3_Silent_p.L78L|ATP5J_ENST00000400087.3_Silent_p.L78L|ATP5J_ENST00000400099.1_Silent_p.L78L|ATP5J_ENST00000400090.3_Silent_p.L78L	NM_001003701.1|NM_001003703.1|NM_001685.4	NP_001003701.1|NP_001003703.1|NP_001676.2	P18859	ATP5J_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6	78					ATP catabolic process|respiratory electron transport chain		hydrogen ion transmembrane transporter activity			cervix(1)|endometrium(1)|lung(1)|pancreas(1)	4						ACATTTGCTTGAGCTTAAAAA	0.383000													12	40					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21862286	21862286	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr14:21862286T>C	ENST00000399982.2	-	31	5732	c.5668A>G	c.(5668-5670)Ata>Gta	p.I1890V	CHD8_ENST00000557364.1_Missense_Mutation_p.I1890V|CHD8_ENST00000430710.3_Missense_Mutation_p.I1611V	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1890					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AGCAATTCTATACGGTAGAGA	0.512000													61	17					0	0	1	0	0
BAALC	79870	broad.mit.edu	37	8	104240299	104240299	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr8:104240299G>A	ENST00000309982.5	+	3	598	c.410G>A	c.(409-411)cGa>cAa	p.R137Q	RP11-318M2.2_ENST00000499522.2_RNA|BAALC_ENST00000438105.2_3'UTR|BAALC_ENST00000297574.6_Missense_Mutation_p.R172Q|BAALC_ENST00000523754.1_3'UTR|RP11-318M2.2_ENST00000523614.2_RNA	NM_024812.2	NP_079088.1	Q8WXS3	BAALC_HUMAN	brain and acute leukemia, cytoplasmic	172						centrosome|membrane|nucleus				kidney(1)|large_intestine(3)|lung(3)	7			OV - Ovarian serous cystadenocarcinoma(57;3.49e-05)|STAD - Stomach adenocarcinoma(118;0.133)			GACAGAAGTCGAAGAATCACA	0.438000													11	60					0	0	1	0	0
CYP2R1	120227	broad.mit.edu	37	11	14913743	14913743	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:14913743C>A	ENST00000334636.5	-	1	55	c.9G>T	c.(7-9)aaG>aaT	p.K3N		NM_024514.4	NP_078790.2	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R, polypeptide 1	3					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	CTCTCCAAAGCTTCCACATCG	0.672000													6	15					1	1	1	1	0
CXCL6	6372	broad.mit.edu	37	4	74702999	74702999	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr4:74702999G>A	ENST00000226317.5	+	3	576	c.322G>A	c.(322-324)Gac>Aac	p.D108N	CXCL6_ENST00000515050.1_Missense_Mutation_p.D108N|CXCL6_ENST00000503446.1_3'UTR	NM_002993.3	NP_002984.1	P80162	CXCL6_HUMAN	chemokine (C-X-C motif) ligand 6	108					cell-cell signaling|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding			large_intestine(1)|lung(7)	8	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GAAAATTTTGGACAGGTATTT	0.393000													29	85					0	0	1	0	0
ZFPL1	7542	broad.mit.edu	37	11	64855502	64855502	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:64855502G>T	ENST00000294258.3	+	8	1001	c.849G>T	c.(847-849)atG>atT	p.M283I		NM_006782.3	NP_006773.2	O95159	ZFPL1_HUMAN	zinc finger protein-like 1	283					regulation of transcription, DNA-dependent|vesicle-mediated transport	Golgi apparatus|integral to membrane|nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	11						TTGCCCTCATGTCTCGCCTAG	0.692000													29	109					3.33393e-15	3.76463e-15	1	1	0
HAL	3034	broad.mit.edu	37	12	96389516	96389516	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr12:96389516C>A	ENST00000261208.3	-	2	541	c.173G>T	c.(172-174)tGc>tTc	p.C58F	HAL_ENST00000538703.1_Missense_Mutation_p.C58F|HAL_ENST00000541929.1_5'UTR	NM_002108.3	NP_002099.1	P42357	HUTH_HUMAN	histidine ammonia-lyase	58					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	34					L-Histidine(DB00117)	CAGGCCCTTGCACCGGCGCAC	0.647000													7	64					8.12818e-05	8.41338e-05	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113871474	113871474	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr8:113871474A>C	ENST00000297405.5	-	11	1899	c.1655T>G	c.(1654-1656)cTt>cGt	p.L552R	CSMD3_ENST00000343508.3_Missense_Mutation_p.L512R|CSMD3_ENST00000455883.2_Missense_Mutation_p.L448R|CSMD3_ENST00000352409.3_Missense_Mutation_p.L552R	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	552	CUB 3.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGGTCCTTGAAGATTAGAGCC	0.358000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			21	113					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													8	53					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178927974	178927974	+	Splice_Site	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:178927974G>A	ENST00000263967.3	+	8	1409	c.1251_splice	c.e8-1	p.E418_splice		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	418	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E418K(6)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GTTTTTTAAGGAACACTGTCC	0.323000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			17	105					0	0	1	0	0
LYPLAL1	127018	broad.mit.edu	37	1	219384841	219384841	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:219384841A>C	ENST00000366928.5	+	5	532	c.485A>C	c.(484-486)cAg>cCg	p.Q162P	LYPLAL1_ENST00000483635.1_3'UTR|LYPLAL1_ENST00000366927.3_Missense_Mutation_p.Q146P	NM_138794.3	NP_620149.1	Q5VWZ2	LYPL1_HUMAN	lysophospholipase-like 1	162						cytoplasm	lysophospholipase activity			large_intestine(1)|lung(5)	6				GBM - Glioblastoma multiforme(131;0.055)|all cancers(67;0.105)|OV - Ovarian serous cystadenocarcinoma(81;0.116)		TAGGCTCTTCAGAAGAGTAAT	0.338000													12	99					0	0	1	0	0
C5orf20	140947	broad.mit.edu	37	5	134782660	134782660	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr5:134782660C>G	ENST00000503143.2	-	1	378	c.139G>C	c.(139-141)Gag>Cag	p.E47Q	TIFAB_ENST00000537858.1_3'UTR	NM_130848.2	NP_570900.1	Q8TF63	DCNP1_HUMAN	chromosome 5 open reading frame 20	47						nucleus				endometrium(1)|lung(1)|prostate(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CCAAAGTTCTCTGGTGGAGCT	0.612000													8	10					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476158	120476158	+	Silent	SNP	T	T	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr9:120476158T>G	ENST00000355622.6	+	3	1853	c.1752T>G	c.(1750-1752)acT>acG	p.T584T	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Silent_p.T544T	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	584	LRRCT.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TTGCTTGTACTTGTGAACACC	0.418000													20	45					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56484340	56484340	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr6:56484340C>G	ENST00000370765.6	-	23	4599	c.4492G>C	c.(4492-4494)Gag>Cag	p.E1498Q	DST_ENST00000361203.3_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000370754.5_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000446842.2_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	5177					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATATTCTTCTCAGCTACAGCA	0.323000													15	69					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120009357	120009357	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chrX:120009357C>T	ENST00000371311.3	-	1	422	c.168G>A	c.(166-168)ggG>ggA	p.G56G		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	56										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						CTTCCACGGGCCCTGCGACTC	0.746000													11	30					0	0	1	0	0
CCDC150	284992	broad.mit.edu	37	2	197584280	197584280	+	Silent	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:197584280C>T	ENST00000389175.4	+	19	2190	c.2055C>T	c.(2053-2055)atC>atT	p.I685I	CCDC150_ENST00000487663.1_3'UTR|CCDC150_ENST00000272831.7_Silent_p.I332I|CCDC150_ENST00000409270.1_Silent_p.I172I	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	685										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						AAGTCACAATCATGTTGGAGA	0.438000													4	123					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94129050	94129050	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr6:94129050G>C	ENST00000369303.4	-	1	194	c.10C>G	c.(10-12)Caa>Gaa	p.Q4E	EPHA7_ENST00000369297.1_Missense_Mutation_p.Q4E	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	4						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TACCGAGTTTGAAAAACCATG	0.438000													84	437					0	0	1	0	0
ALS2CR12	130540	broad.mit.edu	37	2	202153425	202153425	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:202153425C>A	ENST00000405148.2	-	15	1734	c.1291G>T	c.(1291-1293)Gat>Tat	p.D431Y	ALS2CR12_ENST00000439709.1_Missense_Mutation_p.D408Y|ALS2CR12_ENST00000286190.5_Missense_Mutation_p.D431Y|ALS2CR12_ENST00000392257.3_Missense_Mutation_p.D408Y	NM_139163.2	NP_631902.2	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12	431					regulation of GTPase activity		protein binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)	21						GTGTCAGAATCATCCTTAGAA	0.373000													14	44					3.27435e-08	3.54471e-08	1	1	0
SLC45A4	57210	broad.mit.edu	37	8	142228950	142228950	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr8:142228950C>A	ENST00000519067.1	-	4	939	c.636G>T	c.(634-636)gaG>gaT	p.E212D	SLC45A4_ENST00000517878.1_Missense_Mutation_p.E263D|SLC45A4_ENST00000433583.2_Missense_Mutation_p.E205D|SLC45A4_ENST00000024061.3_Missense_Mutation_p.E212D			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	263					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CAGCGCTGCGCTCCTGCTGCG	0.662000													6	194					3.59834e-05	3.77425e-05	1	1	0
ALPP	250	broad.mit.edu	37	2	233246071	233246071	+	Missense_Mutation	SNP	G	G	A	rs146681711		TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:233246071G>A	ENST00000392027.2	+	10	1572	c.1303G>A	c.(1303-1305)Gag>Aag	p.E435K	AC068134.8_ENST00000441266.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	435						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		TACCGAGAGCGAGAGCGGTGA	0.672000													7	30					0	0	1	0	0
ARNT	405	broad.mit.edu	37	1	150830859	150830859	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:150830859C>T	ENST00000358595.5	-	2	303	c.103G>A	c.(103-105)Gcc>Acc	p.A35T	ARNT_ENST00000505755.1_Missense_Mutation_p.A35T|ARNT_ENST00000354396.2_Missense_Mutation_p.A35T|ARNT_ENST00000515192.1_Missense_Mutation_p.A26T	NM_001197325.1|NM_001668.3|NM_178427.2	NP_001184254.1|NP_001659.1|NP_848514.1	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	35					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|prostate(2)|skin(4)|stomach(1)	34	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGGACAATGGCTCCTCCACCT	0.433000			T	ETV6	AML								8	42					0	0	1	0	0
SERTAD2	9792	broad.mit.edu	37	2	64863635	64863635	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:64863635G>A	ENST00000313349.3	-	2	668	c.371C>T	c.(370-372)aCg>aTg	p.T124M		NM_014755.2	NP_055570.1	Q14140	SRTD2_HUMAN	SERTA domain containing 2	124					negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus				breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|skin(1)	12						CTCCAGGGGCGTAGTGCTTCC	0.697000													13	67					0	0	1	0	0
IL6R	3570	broad.mit.edu	37	1	154407115	154407115	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr1:154407115C>G	ENST00000368485.3	+	4	1016	c.579C>G	c.(577-579)tgC>tgG	p.C193W	IL6R_ENST00000344086.4_Missense_Mutation_p.C193W	NM_000565.3	NP_000556.1	P08887	IL6RA_HUMAN	interleukin 6 receptor	193					acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity		IL6R/ATP8B2(2)	breast(2)|large_intestine(1)|ovary(3)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGTCCATGTGCGTCGCCAGTA	0.527000													4	147					0	0	1	0	0
ABLIM3	22885	broad.mit.edu	37	5	148619446	148619446	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr5:148619446G>A	ENST00000506113.1	+	12	1681	c.1199G>A	c.(1198-1200)cGc>cAc	p.R400H	RP11-331K21.1_ENST00000522685.1_RNA|ABLIM3_ENST00000326685.7_Missense_Mutation_p.R338H|AC012613.2_ENST00000523176.1_RNA|ABLIM3_ENST00000504238.1_Missense_Mutation_p.R338H|ABLIM3_ENST00000508983.1_Missense_Mutation_p.R400H|ABLIM3_ENST00000309868.7_Missense_Mutation_p.R400H|ABLIM3_ENST00000356541.3_Missense_Mutation_p.R338H|RP11-331K21.1_ENST00000512647.2_RNA|ABLIM3_ENST00000519549.1_3'UTR			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	400					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACTACTACCGCTCTGGTAAG	0.642000													18	46					0	0	1	0	0
PRRT2	112476	broad.mit.edu	37	16	29825093	29825093	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr16:29825093C>T	ENST00000300797.6	+	2	892	c.718C>T	c.(718-720)Cga>Tga	p.R240*	PRRT2_ENST00000567659.1_Nonsense_Mutation_p.R240*|PRRT2_ENST00000567551.1_3'UTR|PRRT2_ENST00000358758.7_Nonsense_Mutation_p.R240*|AC009133.20_ENST00000569039.1_RNA			Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	240					response to biotic stimulus	integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	8						AGGATCTCCCCGAGGTAGCCT	0.637000													6	25					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4839057	4839057	+	Silent	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr7:4839057G>A	ENST00000399583.3	-	15	3367	c.3180C>T	c.(3178-3180)tcC>tcT	p.S1060S	RADIL_ENST00000538469.1_Silent_p.S820S|RADIL_ENST00000536091.1_3'UTR	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	1060	PDZ.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		TTTCCACGTCGGACTTCGCGA	0.647000													42	51					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137294342	137294342	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr7:137294342G>A	ENST00000453654.1	-	9	646	c.107C>T	c.(106-108)gCt>gTt	p.A36V	DGKI_ENST00000424189.2_Missense_Mutation_p.A336V|DGKI_ENST00000288490.5_Missense_Mutation_p.A336V|DGKI_ENST00000446122.1_Missense_Mutation_p.A336V			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	336					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						CCGATTTGAAGCCTTCAGGGA	0.458000													8	46					0	0	1	0	0
PRKD2	25865	broad.mit.edu	37	19	47197242	47197242	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:47197242G>C	ENST00000433867.1	-	11	1943	c.1466C>G	c.(1465-1467)cCa>cGa	p.P489R	PRKD2_ENST00000601806.1_Missense_Mutation_p.P332R|PRKD2_ENST00000291281.4_Missense_Mutation_p.P489R|PRKD2_ENST00000595515.1_Missense_Mutation_p.P489R|PRKD2_ENST00000600194.1_Missense_Mutation_p.P332R	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349.1|NP_001073350.1|NP_057541.2	Q9BZL6	KPCD2_HUMAN	protein kinase D2	489	PH.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		CTGCCCACTTGGCCCACCCGG	0.692000													13	69					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	150908513	150908513	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:150908513A>G	ENST00000474524.1	+	13	1801	c.1763A>G	c.(1762-1764)aAc>aGc	p.N588S	MED12L_ENST00000273432.4_Missense_Mutation_p.N448S|MED12L_ENST00000309237.4_Missense_Mutation_p.N588S|MED12L_ENST00000422248.2_Missense_Mutation_p.N588S	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	588					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCGGACCCAAACAGTGAATGT	0.403000													23	27					0	0	1	0	0
ZNF599	148103	broad.mit.edu	37	19	35251299	35251299	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:35251299C>A	ENST00000329285.7	-	4	780	c.407G>T	c.(406-408)aGg>aTg	p.R136M		NM_001007248.2	NP_001007249.1	Q96NL3	ZN599_HUMAN	zinc finger protein 599	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|skin(1)	24	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			TGTTCCTGGCCTCAAGTTCCC	0.443000													31	148					2.48696e-23	2.84914e-23	1	1	0
ZNF649	65251	broad.mit.edu	37	19	52394714	52394714	+	Silent	SNP	C	C	T	rs149943001		TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr19:52394714C>T	ENST00000354957.3	-	5	959	c.675G>A	c.(673-675)gaG>gaA	p.E225E	ZNF649_ENST00000600738.1_Intron|CTC-429C10.2_ENST00000600329.1_RNA	NM_023074.3	NP_075562.2	Q9BS31	ZN649_HUMAN	zinc finger protein 649	225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		TGTGAGCTCTCTCGTGTTCAG	0.498000													19	123					0	0	1	0	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89100588	89100588	+	RNA	DEL	A	A	-			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:89100588delA	ENST00000393525.3	+	0	1089																											TTTGTCAACTAAAAAAACAAA	0.343													20	70	---	---	---	---					
ANKRD36BP2	645784	broad.mit.edu	37	2	89104896	89104896	+	RNA	DEL	C	C	-	rs5832744		TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:89104896delC	ENST00000393525.3	+	0	4872																											ATTTCAGATGCCACAGGTGTT	0.313													2	4	---	---	---	---					
RBM43	375287	broad.mit.edu	37	2	152108088	152108088	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr2:152108088delT	ENST00000331426.5	-	4	557	c.406delA	c.(406-408)tcfs	p.I136fs		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	136							nucleotide binding|RNA binding	p.I136fs*4(1)		endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		AAACTCGGGATTTTTTTTTTC	0.388													8	199	---	---	---	---					
LINC00969	440993	broad.mit.edu	37	3	195400918	195400919	+	RNA	INS	-	-	TT	rs55992531	by1000genomes	TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr3:195400918_195400919insTT	ENST00000445430.1	+	0	1454																											AGTCttttttctttttttttga	0.525													7	10	---	---	---	---					
NOL7	51406	broad.mit.edu	37	6	13615668	13615670	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr6:13615668_13615670delGGA	ENST00000451315.2	+	1	110_112	c.78_80delGGA	c.(76-81)tcg>tc	p.SE26del		NM_016167.3	NP_057251.2	Q9UMY1	NOL7_HUMAN	nucleolar protein 7, 27kDa	26						mitochondrion|nucleolus				breast(1)|large_intestine(3)|lung(1)	5	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.135)	Epithelial(50;0.176)			AGCTGGCCTCGGAGGAGGAGGAG	0.729											OREG0017200	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
HNRNPKP3	399881	broad.mit.edu	37	11	43283606	43283606	+	RNA	DEL	A	A	-			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:43283606delA	ENST00000511537.1	-	0	1329					NR_033868.1																						AAGCAAATGTAAAAAAAAAAA	0.388													5	6	---	---	---	---					
NUMA1	4926	broad.mit.edu	37	11	71724848	71724849	+	In_Frame_Ins	INS	-	-	CCT			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:71724848_71724849insCCT	ENST00000393695.3	-	15	4031_4032	c.3700_3701insAGG	c.(3700-3702)gtc>AGGgtc	p.1233_1234insR	NUMA1_ENST00000351960.6_Intron|NUMA1_ENST00000358965.6_In_Frame_Ins_p.1233_1234insR	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1233					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						CAGGATGGACACCTCCTCCTCC	0.599			T	RARA	APL								23	116	---	---	---	---					
JRKL	8690	broad.mit.edu	37	11	96124135	96124137	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr11:96124135_96124137delTTC	ENST00000458427.1	+	1	978_980	c.322_324delTTC	c.(322-324)del	p.F110del	JRKL_ENST00000546177.1_Intron|JRKL_ENST00000332349.4_In_Frame_Del_p.F110del	NM_003772.3	NP_003763.2	Q9Y4A0	JERKL_HUMAN	jerky homolog-like (mouse)	110	HTH CENPB-type.				central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)		AAGGGCAGAGTTCTTCTTTTATG	0.438													90	93	---	---	---	---					
STAB2	55576	broad.mit.edu	37	12	104121051	104121061	+	Frame_Shift_Del	DEL	TTCGTGAAAGA	TTCGTGAAAGA	-	rs142064323		TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr12:104121051_104121061delTTCGTGAAAGA	ENST00000388887.2	+	47	5062_5072	c.4858_4868delTTCGTGAAAGA	c.(4858-4869)tfs	p.FVKD1620fs		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1620	FAS1 5.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity	p.F1620F(1)		NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						ACAGGAGCATTTCGTGAAAGATCTGGTCGGC	0.521													24	171	---	---	---	---					
ATXN2	6311	broad.mit.edu	37	12	112036754	112036756	+	In_Frame_Del	DEL	GCT	GCT	-	rs10560189		TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr12:112036754_112036756delGCT	ENST00000377617.3	-	1	724_726	c.563_565delAGC	c.(562-567)ccg>c	p.QP188del	ATXN2_ENST00000550104.1_In_Frame_Del_p.QP188del|ATXN2_ENST00000542287.2_Intron|ATXN2_ENST00000535949.1_Intron|ATXN2_ENST00000549455.1_5'UTR	NM_002973.3	NP_002964.3	Q99700	ATX2_HUMAN	ataxin 2	188				Missing (in Ref. 1; AAB19200 and 5; CAA69589).	cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37						GCGGGCGGCGgctgctgctgctg	0.709													3	3	---	---	---	---					
ZIC5	85416	broad.mit.edu	37	13	100623843	100623844	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr13:100623843_100623844insA	ENST00000267294.4	-	1	319_320	c.86_87insT	c.(85-87)tagfs	p.*29fs		NM_033132.3	NP_149123.2	Q96T25	ZIC5_HUMAN	Zic family member 5	29					cell differentiation	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|lung(2)|prostate(1)|skin(2)	9	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TCCTCTTGCTCAAAGGGGGCTC	0.584													2	4	---	---	---	---					
KRTAP2-4	85294	broad.mit.edu	37	17	39221759	39221773	+	In_Frame_Del	DEL	GCAGGGGGGCCGGCA	GCAGGGGGGCCGGCA	-	rs349782	by1000genomes	TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr17:39221759_39221773delGCAGGGGGGCCGGCA	ENST00000394015.2	-	1	358_372	c.325_339delTGCCGGCCCCCCTGC	c.(325-339)del	p.CRPPC109del		NM_033184.3	NP_149440.1	Q9BYR9	KRA24_HUMAN	keratin associated protein 2-4	109	10 X 5 AA repeats of C-C-[CDPQRW]- [ADPRS]-[CIPSTV].					keratin filament				skin(1)	1		Breast(137;0.000496)|Myeloproliferative disorder(1115;0.204)	STAD - Stomach adenocarcinoma(17;0.000371)			TCGGCTGGCCGCAGGGGGGCCGGCAGCAGGGGGAC	0.660													2	4	---	---	---	---					
KIAA0195	9772	broad.mit.edu	37	17	73495357	73495363	+	Frame_Shift_Del	DEL	ACCAGAA	ACCAGAA	-			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr17:73495357_73495363delACCAGAA	ENST00000314256.7	+	32	4407_4413	c.4013_4019delACCAGAA	c.(4012-4020)tgfs	p.YQK1338fs	KIAA0195_ENST00000375248.5_Frame_Shift_Del_p.YQK1348fs|KIAA0195_ENST00000579208.1_Frame_Shift_Del_p.YQK989fs	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	1338					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGAGTCCGCTACCAGAAGCGACAGAAG	0.589													69	31	---	---	---	---					
FHOD3	80206	broad.mit.edu	37	18	34261459	34261460	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr18:34261459_34261460delAG	ENST00000257209.4	+	12	1493_1494	c.1371_1372delAG	c.(1369-1374)gcagfs	p.AE457fs	FHOD3_ENST00000445677.1_Frame_Shift_Del_p.AE419fs|FHOD3_ENST00000591635.1_Intron|FHOD3_ENST00000590592.1_Frame_Shift_Del_p.AE632fs|FHOD3_ENST00000359247.4_Frame_Shift_Del_p.AE457fs	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	457					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CACTGGCAGCAGAGAGAGAGAG	0.460													9	104	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11049306	11049307	+	RNA	INS	-	-	T	rs57143135		TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr21:11049306_11049307insT	ENST00000470054.1	-	0	659									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATATCCAGTAATTTTTTTAAGT	0.272													9	73	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11078137	11078137	+	RNA	DEL	C	C	-	rs143419676		TCGA-BA-A8YP-01A-11D-A391-08	TCGA-BA-A8YP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14a230ed-5c57-4643-97d4-6218859e62a4	ff13e32c-b2fc-48cd-b2b4-59ea039b7a84	g.chr21:11078137delC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		caaaaattagccaggcgtggt	0.547													3	6	---	---	---	---					
