Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRBV25-1	28562	broad.mit.edu	37	7	142378659	142378659	+	RNA	SNP	T	T	G			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr7:142378659T>G	ENST00000390398.3	+	0	86																											TGGGGGCAGGTAAGTCATAGA	0.478000													16	26					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156753240	156753240	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr5:156753240A>T	ENST00000347377.6	+	18	2475	c.2044A>T	c.(2044-2046)Aaa>Taa	p.K682*	CYFIP2_ENST00000377576.3_Nonsense_Mutation_p.K682*|CYFIP2_ENST00000318218.6_Nonsense_Mutation_p.K707*|CYFIP2_ENST00000520960.1_3'UTR|CYFIP2_ENST00000541131.1_Nonsense_Mutation_p.K607*|CYFIP2_ENST00000522463.1_Nonsense_Mutation_p.K486*|CYFIP2_ENST00000521420.1_Nonsense_Mutation_p.K656*|CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000435847.2_Nonsense_Mutation_p.K381*	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	707					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GACCAAGTTTAAAAAGCAGTT	0.448000													82	32					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24813481	24813481	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr10:24813481C>T	ENST00000376451.2	+	8	1995	c.1735C>T	c.(1735-1737)Ccc>Tcc	p.P579S	KIAA1217_ENST00000376454.3_Missense_Mutation_p.P896S|KIAA1217_ENST00000430453.2_Intron|KIAA1217_ENST00000396446.1_Missense_Mutation_p.P579S|KIAA1217_ENST00000376452.3_Missense_Mutation_p.P861S|KIAA1217_ENST00000307544.6_Missense_Mutation_p.P579S|KIAA1217_ENST00000376462.1_Missense_Mutation_p.P816S|KIAA1217_ENST00000458595.1_Missense_Mutation_p.P861S|KIAA1217_ENST00000396445.1_Missense_Mutation_p.P579S			Q5T5P2	SKT_HUMAN	KIAA1217	896					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GGTCATCCAGCCCTCCCAGCA	0.642000													31	14					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141461118	141461118	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr8:141461118C>T	ENST00000389328.4	-	2	663	c.649G>A	c.(649-651)Ggg>Agg	p.G217R	TRAPPC9_ENST00000389327.3_Missense_Mutation_p.G119R|TRAPPC9_ENST00000438773.2_Missense_Mutation_p.G119R	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	119					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						CCCTGCAGCCCGAAGACAAAG	0.582000													38	51					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108175462	108175462	+	Missense_Mutation	SNP	G	G	A	rs1801516	byFrequency	TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr11:108175462G>A	ENST00000278616.4	+	37	5942	c.5557G>A	c.(5557-5559)Gat>Aat	p.D1853N	ATM_ENST00000452508.2_Missense_Mutation_p.D1853N	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1853			D -> N (common polymorphism; dbSNP:rs1801516).|D -> V (might contribute to B-cell chronic lymphocytic leukemia; dbSNP:rs1801673).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.D1853N(10)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTTACTCCAAGATACAAATGA	0.388000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			5	57					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62212794	62212794	+	Silent	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr8:62212794C>T	ENST00000519846.1	+	3	880	c.408C>T	c.(406-408)taC>taT	p.Y136Y	CLVS1_ENST00000518592.1_Intron|CLVS1_ENST00000325897.4_Silent_p.Y136Y|RP11-787D18.1_ENST00000518064.1_RNA			Q8IUQ0	CLVS1_HUMAN	clavesin 1	136	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity	p.Y136*(1)		endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						GAGACCATTACGGCAGGAAGA	0.443000													32	38					0	0	1	0	0
NOXRED1	122945	broad.mit.edu	37	14	77872436	77872436	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr14:77872436T>C	ENST00000380835.2	-	5	891	c.725A>G	c.(724-726)tAt>tGt	p.Y242C		NM_001113475.2	NP_001106946.1	Q6NXP6	CN148_HUMAN	NADP-dependent oxidoreductase domain containing 1	242					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	9						TAGGGCCGCATAGAACACTCC	0.463000													12	26					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121206858	121206858	+	Silent	SNP	T	T	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr3:121206858T>A	ENST00000264233.5	-	16	5048	c.4920A>T	c.(4918-4920)ccA>ccT	p.P1640P		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	1640					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TTTGCAGTCCTGGACTTAGAT	0.348000								DNA polymerases (catalytic subunits)					78	317					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25168432	25168432	+	RNA	SNP	T	T	C	rs149337771	by1000genomes	TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr13:25168432T>C	ENST00000453498.1	+	0	1104																											TTGAAACAGCTGGTGTATTAA	0.373000													4	8					0	0	1	0	0
MNS1	55329	broad.mit.edu	37	15	56748690	56748690	+	Silent	SNP	G	G	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr15:56748690G>T	ENST00000260453.3	-	3	419	c.255C>A	c.(253-255)ctC>ctA	p.L85L		NM_018365.2	NP_060835.1	Q8NEH6	MNS1_HUMAN	meiosis-specific nuclear structural 1	85	Glu-rich.				meiosis					breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	20				all cancers(107;0.0196)|GBM - Glioblastoma multiforme(80;0.101)		GTTTGAGCTGGAGTTCTTTCA	0.348000													12	38					0.00010058	0.000103538	1	1	0
OR4E2	26686	broad.mit.edu	37	14	22133973	22133973	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr14:22133973G>A	ENST00000408935.1	+	1	677	c.677G>A	c.(676-678)cGa>cAa	p.R226Q		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		GTTTCTCTTCGAAAACACTCA	0.502000													63	70					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2347470	2347470	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr16:2347470T>C	ENST00000301732.5	-	17	2823	c.2123A>G	c.(2122-2124)cAg>cGg	p.Q708R	ABCA3_ENST00000382381.3_Missense_Mutation_p.Q650R	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	708	ABC transporter 1.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.Q708R(1)		breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				TTTCTGCCGCTGAAGAAGATC	0.622000													62	29					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73850051	73850051	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr8:73850051G>A	ENST00000523207.1	+	3	3049	c.2461G>A	c.(2461-2463)Gca>Aca	p.A821T		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	821					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GCTCCCAGGGGCAAGGGAGGA	0.507000													45	77					0	0	1	0	0
CDCA4	55038	broad.mit.edu	37	14	105478059	105478059	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr14:105478059G>C	ENST00000336219.3	-	2	363	c.208C>G	c.(208-210)Caa>Gaa	p.Q70E	CDCA4_ENST00000392590.3_Missense_Mutation_p.Q70E	NM_017955.3	NP_060425.2	Q9BXL8	CDCA4_HUMAN	cell division cycle associated 4	70	SERTA.					nucleus				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.142)		ATCTCCTCTTGGATCTGCCGG	0.632000													43	50					0	0	1	0	0
PPP2R2D	55844	broad.mit.edu	37	10	133761152	133761152	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr10:133761152G>A	ENST00000422256.2	+	6	741	c.256G>A	c.(256-258)Ggt>Agt	p.G86S	PPP2R2D_ENST00000470416.1_3'UTR			Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B, delta	56					cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			endometrium(3)|large_intestine(3)|liver(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		ACTACCTGTCGGTGAAGGTGT	0.512000													36	14					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6897559	6897559	+	Splice_Site	SNP	G	G	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr19:6897559G>T	ENST00000312053.4	+	5	551		c.e5+1		EMR1_ENST00000381407.5_Intron|EMR1_ENST00000450315.3_Intron|EMR1_ENST00000250572.8_Splice_Site|EMR1_ENST00000601198.1_Splice_Site|EMR1_ENST00000381404.4_Splice_Site	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1						cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					ACCTGTGAAGGTATCCATGAC	0.423000													38	37					2.87052e-16	3.17268e-16	1	1	0
MFHAS1	9258	broad.mit.edu	37	8	8748872	8748872	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr8:8748872G>A	ENST00000276282.6	-	1	2283	c.1697C>T	c.(1696-1698)gCg>gTg	p.A566V		NM_004225.2	NP_004216.2	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified sequence 1	566	Roc.									endometrium(1)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|stomach(1)	21		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		CAGTCCCTCCGCGTCGTGCTT	0.652000													24	51					0	0	1	0	0
STYK1	55359	broad.mit.edu	37	12	10774533	10774533	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr12:10774533G>C	ENST00000075503.3	-	10	1526	c.1006C>G	c.(1006-1008)Cta>Gta	p.L336V		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	336	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						AGATGCTCTAGGATGCTGGTA	0.418000										HNSCC(73;0.22)			42	87					0	0	1	0	0
MST1	4485	broad.mit.edu	37	3	49723603	49723603	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr3:49723603G>A	ENST00000449682.2	-	9	1400	c.1039C>T	c.(1039-1041)Cgg>Tgg	p.R347W	MST1_ENST00000383728.3_3'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	333	Kringle 3.				proteolysis	extracellular region	serine-type endopeptidase activity	p.R333W(5)		NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCGGGGTTCCGGCAGAAGTTC	0.662000													3	14					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92797181	92797181	+	Silent	SNP	T	T	C			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr13:92797181T>C	ENST00000377067.3	+	7	1872	c.1500T>C	c.(1498-1500)gaT>gaC	p.D500D		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	500						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				ACTGTGATGATGAAGATGGTT	0.463000													68	18					0	0	1	0	0
CUL3	8452	broad.mit.edu	37	2	225342966	225342966	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr2:225342966C>T	ENST00000264414.4	-	15	2464	c.2126G>A	c.(2125-2127)cGg>cAg	p.R709Q	CUL3_ENST00000409096.1_Missense_Mutation_p.R685Q|CUL3_ENST00000409777.1_Missense_Mutation_p.R685Q|CUL3_ENST00000344951.4_Missense_Mutation_p.R643Q	NM_003590.4	NP_003581.1	Q13618	CUL3_HUMAN	cullin 3	709					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding	p.R709Q(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TTTCATTATCCGCACTATAGC	0.408000													34	5					0	0	1	0	0
TMEM123	114908	broad.mit.edu	37	11	102272718	102272718	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr11:102272718G>A	ENST00000398136.2	-	3	797	c.377C>T	c.(376-378)tCt>tTt	p.S126F	TMEM123_ENST00000532161.1_Missense_Mutation_p.S38F|TMEM123_ENST00000525577.1_5'UTR|TMEM123_ENST00000361236.3_Missense_Mutation_p.S107F	NM_052932.2	NP_443164.2	Q8N131	PORIM_HUMAN	transmembrane protein 123	126	Thr-rich.				oncosis	external side of plasma membrane|integral to membrane	receptor activity			breast(3)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	9	all_cancers(8;0.00027)|all_epithelial(12;0.0021)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0314)|Lung(13;0.109)|all cancers(10;0.12)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0149)		TGATATCTGAGATGTGTTCTG	0.398000													49	121					0	0	1	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100801716	100801716	+	Silent	SNP	C	C	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr15:100801716C>A	ENST00000268070.4	-	6	1104	c.999G>T	c.(997-999)ccG>ccT	p.P333P		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	333	Peptidase M12B.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CCACCAGGGGCGGGTCGTCCT	0.562000													9	39					7.48243e-07	7.93591e-07	1	1	0
CRAMP1L	57585	broad.mit.edu	37	16	1718076	1718076	+	Silent	SNP	C	C	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr16:1718076C>A	ENST00000397412.3	+	18	3315	c.3216C>A	c.(3214-3216)gtC>gtA	p.V1072V	CRAMP1L_ENST00000436138.3_Silent_p.V1069V|CRAMP1L_ENST00000293925.5_Silent_p.V1072V|CRAMP1L_ENST00000262317.4_Silent_p.V450V|LA16c-431H6.6_ENST00000454337.1_3'UTR			Q96RY5	CRML_HUMAN	Crm, cramped-like (Drosophila)	1072	Ser-rich.					nucleus	DNA binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)	22						CACCAGACGTCTCTGCTCTGC	0.612000													9	44					1.12685e-05	1.17148e-05	1	1	0
SYNE3	161176	broad.mit.edu	37	14	95923521	95923521	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr14:95923521G>T	ENST00000334258.5	-	4	796	c.782C>A	c.(781-783)aCa>aAa	p.T261K	SYNE3_ENST00000553340.1_Missense_Mutation_p.T261K|SYNE3_ENST00000557275.1_Missense_Mutation_p.T261K	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						TACCTGCAGTGTGGAGAGGCG	0.542000													59	113					1.44317e-28	1.6652e-28	1	1	0
ADAP1	11033	broad.mit.edu	37	7	959664	959664	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr7:959664C>T	ENST00000265846.5	-	4	548	c.329G>A	c.(328-330)cGg>cAg	p.R110Q	ADAP1_ENST00000463358.1_5'UTR|ADAP1_ENST00000539900.1_Missense_Mutation_p.R121Q|ADAP1_ENST00000449296.2_Missense_Mutation_p.R38Q	NM_006869.2	NP_006860.1	O75689	ADAP1_HUMAN	ArfGAP with dual PH domains 1	110	Arf-GAP.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding	p.R110Q(1)		endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	6						GTACTTGGCCCGGATCCACTG	0.682000													10	17					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145640051	145640051	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr4:145640051G>A	ENST00000296575.3	+	11	2358	c.1703G>A	c.(1702-1704)aGt>aAt	p.S568N		NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	568						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding	p.S568N(1)		central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TTATCAAGCAGTAAAAGTATG	0.333000													29	9					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72489877	72489877	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr10:72489877G>A	ENST00000373208.1	+	6	974	c.974G>A	c.(973-975)cGc>cAc	p.R325H	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.R325H	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	325	Peptidase M12B.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.R325H(1)		NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						CTGATCGAGCGCGGGAACCCC	0.652000													38	21					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103155716	103155716	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr7:103155716C>G	ENST00000424685.2	-	50	8194	c.8035G>C	c.(8035-8037)Gta>Cta	p.V2679L	RELN_ENST00000428762.1_Missense_Mutation_p.V2679L|RELN_ENST00000343529.5_Missense_Mutation_p.V2679L			P78509	RELN_HUMAN	reelin	2679					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.V2679L(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGCTGGGGTACTGGGGCGCTG	0.552000													23	31					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45353231	45353231	+	Missense_Mutation	SNP	G	G	A	rs146123836		TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr5:45353231G>A	ENST00000303230.4	-	5	1405	c.1348C>T	c.(1348-1350)Ctc>Ttc	p.L450F		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	450						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						AGTTCATTGAGAATATTTTCC	0.338000													37	67					0	0	1	0	0
KCNH3	23416	broad.mit.edu	37	12	49942697	49942697	+	Silent	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr12:49942697C>T	ENST00000257981.6	+	8	1469	c.1209C>T	c.(1207-1209)gcC>gcT	p.A403A		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	403					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						AGGAGCTGGCCCGCCGACTGG	0.692000													3	15					0	0	1	0	0
NME1	4830	broad.mit.edu	37	17	49237412	49237412	+	Silent	SNP	A	A	G			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr17:49237412A>G	ENST00000511355.1	+	3	284	c.198A>G	c.(196-198)aaA>aaG	p.K66K	NME1_ENST00000336097.3_Silent_p.K91K|NME1_ENST00000393196.3_Silent_p.K66K|NME2_ENST00000376392.6_Silent_p.K66K|NME1_ENST00000480143.1_Silent_p.K91K|NME2_ENST00000393193.2_Silent_p.K66K|NME2_ENST00000555572.1_Silent_p.K91K|NME1_ENST00000013034.3_Silent_p.K91K					NME/NM23 nucleoside diphosphate kinase 1											endometrium(1)|large_intestine(1)|lung(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			GCCTGGTGAAATACATGCACT	0.488000													70	105					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134151992	134151992	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr11:134151992A>G	ENST00000389887.5	+	5	3001	c.505A>G	c.(505-507)Atg>Gtg	p.M169V	GLB1L3_ENST00000431683.2_Missense_Mutation_p.M169V			Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	169					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		CTGCAGTGAGATGGACCTCGG	0.552000													11	6					0	0	1	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130415450	130415450	+	Silent	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr6:130415450C>T	ENST00000529410.1	+	20	2153	c.1674C>T	c.(1672-1674)tgC>tgT	p.C558C	L3MBTL3_ENST00000368139.2_Silent_p.C533C|L3MBTL3_ENST00000533560.1_Silent_p.C533C|L3MBTL3_ENST00000361794.2_Silent_p.C558C|L3MBTL3_ENST00000526019.1_Silent_p.C533C|L3MBTL3_ENST00000368136.2_Silent_p.C558C			Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 (Drosophila)	558					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|skin(4)|stomach(1)|urinary_tract(1)	43				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		ATGGTGGATGCTCAACCCCGG	0.448000													23	28					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57193797	57193797	+	Silent	SNP	A	A	G			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr7:57193797A>G	ENST00000331162.4	-	4	460	c.190T>C	c.(190-192)Ttg>Ctg	p.L64L		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	64	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			CAGGTGATCAAGTCTGGCTTA	0.368000													39	104					0	0	1	0	0
C17orf104	284071	broad.mit.edu	37	17	42745255	42745255	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr17:42745255G>A	ENST00000409122.2	+	5	2118	c.1976G>A	c.(1975-1977)cGc>cAc	p.R659H	C17orf104_ENST00000409464.1_Missense_Mutation_p.R493H|C17orf104_ENST00000359945.3_Missense_Mutation_p.R659H	NM_001145080.2	NP_001138552.2	A2RUB1	CQ104_HUMAN	chromosome 17 open reading frame 104	659										autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|pancreas(1)|skin(1)	24						CGTGTGAATCGCACACAAGTG	0.398000													26	32					0	0	1	0	0
AMD1	262	broad.mit.edu	37	6	111214719	111214719	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr6:111214719T>C	ENST00000368885.3	+	9	1241	c.905T>C	c.(904-906)aTt>aCt	p.I302T	AMD1_ENST00000451850.2_Missense_Mutation_p.I182T|AMD1_ENST00000368882.3_Missense_Mutation_p.I154T|AMD1_ENST00000368877.5_Missense_Mutation_p.I273T|AMD1_ENST00000368876.1_Missense_Mutation_p.I233T	NM_001634.4	NP_001625.2	P17707	DCAM_HUMAN	adenosylmethionine decarboxylase 1	302					spermidine biosynthetic process|spermine biosynthetic process	cytosol	adenosylmethionine decarboxylase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(2)	8		all_cancers(87;3.83e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.0522)|Epithelial(106;0.111)|all cancers(137;0.143)	S-Adenosylmethionine(DB00118)	CCCCAGAAGATTGAAGGTTTT	0.388000													60	62					0	0	1	0	0
VAX2	25806	broad.mit.edu	37	2	71160180	71160180	+	Missense_Mutation	SNP	C	C	A	rs140956448	byFrequency	TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr2:71160180C>A	ENST00000234392.2	+	3	751	c.719C>A	c.(718-720)cCa>cAa	p.P240Q		NM_012476.2	NP_036608.1	Q9UIW0	VAX2_HUMAN	ventral anterior homeobox 2	240					ectoderm development|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	7						GCGTCCCCCCCACTGCCGCCC	0.682000													4	44					0.00909568	0.00918314	1	1	0
EXOC7	23265	broad.mit.edu	37	17	74097810	74097810	+	Silent	SNP	G	G	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr17:74097810G>T	ENST00000607838.1	-	3	355	c.261C>A	c.(259-261)gtC>gtA	p.V87V	EXOC7_ENST00000467929.2_Silent_p.V46V|EXOC7_ENST00000411744.2_Silent_p.V87V|EXOC7_ENST00000406660.3_Silent_p.V87V|EXOC7_ENST00000405575.4_Silent_p.V87V|EXOC7_ENST00000335146.7_Silent_p.V87V|EXOC7_ENST00000332065.5_Silent_p.V87V|EXOC7_ENST00000589210.1_Silent_p.V87V	NM_001145297.2|NM_001145298.2|NM_001145299.2	NP_001138769.1|NP_001138770.1|NP_001138771.1	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7	87					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	14			LUSC - Lung squamous cell carcinoma(166;0.187)			AGTAGCTGATGACATGGTCCA	0.547000													67	99					1.08241e-25	1.22207e-25	1	1	0
UBR2	23304	broad.mit.edu	37	6	42608004	42608004	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr6:42608004C>T	ENST00000372899.1	+	16	2174	c.1916C>T	c.(1915-1917)cCt>cTt	p.P639L	UBR2_ENST00000372883.3_Missense_Mutation_p.P143L|UBR2_ENST00000372901.1_Missense_Mutation_p.P639L	NM_015255.2	NP_056070.1	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	639					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GAGCTCCTACCTCTAGTAAGT	0.303000													18	27					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43262351	43262351	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr18:43262351A>T	ENST00000255226.6	+	20	3446	c.2630A>T	c.(2629-2631)aAt>aTt	p.N877I	RP11-116O18.3_ENST00000589510.1_RNA|SLC14A2_ENST00000586448.1_Missense_Mutation_p.N877I|SLC14A2_ENST00000589658.1_Missense_Mutation_p.N354I	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	877						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity	p.N877I(1)		NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CTGACGACCAATAACCCCGCC	0.542000													151	64					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155449890	155449890	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr1:155449890G>C	ENST00000368346.3	-	3	3410	c.2771C>G	c.(2770-2772)tCt>tGt	p.S924C	ASH1L_ENST00000392403.3_Missense_Mutation_p.S924C			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	924					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding	p.S924C(1)		autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GTCACTTTCAGATTCTAGCTT	0.473000													109	114					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30703211	30703211	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr8:30703211C>A	ENST00000256246.2	-	1	3397	c.3323G>T	c.(3322-3324)aGt>aTt	p.S1108I		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1108	Ser-rich.							p.S1108I(1)		NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GCTAGCCATACTTTTCCTAGA	0.393000													41	65					6.33695e-27	7.23239e-27	1	1	0
NOX5	79400	broad.mit.edu	37	15	69347794	69347794	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr15:69347794C>T	ENST00000260364.5	+	16	2367	c.2066C>T	c.(2065-2067)aCg>aTg	p.T689M	NOX5_ENST00000530406.2_Missense_Mutation_p.T679M|NOX5_ENST00000448182.3_Missense_Mutation_p.T661M|NOX5_ENST00000388866.3_Missense_Mutation_p.T707M|NOX5_ENST00000455873.3_Missense_Mutation_p.T672M			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	707					angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						GACTCCATCACGGGGCTGCAG	0.577000													32	27					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33590472	33590472	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr2:33590472G>A	ENST00000404816.2	+	31	4966	c.4613G>A	c.(4612-4614)cGg>cAg	p.R1538Q	LTBP1_ENST00000272273.5_Missense_Mutation_p.R436Q|LTBP1_ENST00000407925.1_Missense_Mutation_p.R1212Q|LTBP1_ENST00000418533.2_Missense_Mutation_p.R1170Q|LTBP1_ENST00000390003.4_Missense_Mutation_p.R1213Q|LTBP1_ENST00000354476.3_Missense_Mutation_p.R1539Q|LTBP1_ENST00000404525.1_Missense_Mutation_p.R1159Q|LTBP1_ENST00000402934.1_Missense_Mutation_p.R1157Q			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1538	TB 4.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GTGTGTAGCCGGCCTCTTGTG	0.498000													37	27					0	0	1	0	0
HOMER3	9454	broad.mit.edu	37	19	19049612	19049612	+	Silent	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr19:19049612C>T	ENST00000539827.1	-	2	748	c.96G>A	c.(94-96)aaG>aaA	p.K32K	HOMER3_ENST00000392351.3_Silent_p.K32K|HOMER3_ENST00000355887.6_Silent_p.K32K|HOMER3_ENST00000542541.2_Silent_p.K32K|HOMER3_ENST00000594439.1_Silent_p.K32K|HOMER3_ENST00000221222.11_Silent_p.K32K|HOMER3_ENST00000433218.2_Silent_p.K32K|HOMER3_ENST00000594794.1_Intron			Q9NSC5	HOME3_HUMAN	homer homolog 3 (Drosophila)	32	WH1.				metabotropic glutamate receptor signaling pathway|protein targeting	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	protein binding			endometrium(3)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	10			Epithelial(12;0.0107)			TGAGTGCGTGCTTGCCCGCTG	0.607000													9	9					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79387450	79387450	+	Silent	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr1:79387450G>A	ENST00000370742.3	-	9	1168	c.1105C>T	c.(1105-1107)Cta>Tta	p.L369L		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	369	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		AATGCACATAGACTCCTATAC	0.378000													27	8					0	0	1	0	0
CCR4	1233	broad.mit.edu	37	3	32995557	32995557	+	Silent	SNP	T	T	C			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr3:32995557T>C	ENST00000330953.5	+	2	811	c.643T>C	c.(643-645)Tta>Cta	p.L215L		NM_005508.4	NP_005499.1	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	215					chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				NS(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)|stomach(1)	16						GGTGATCCCCTTAGGGATCAT	0.473000													92	22					0	0	1	0	0
RPL32P3	132241	broad.mit.edu	37	3	129115896	129115896	+	RNA	SNP	T	T	C			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr3:129115896T>C	ENST00000514355.1	-	0	499																				lung(1)	1						GATTTTGACATATCGGTCTGA	0.493000													183	274					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113559376	113559376	+	Silent	SNP	C	C	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr12:113559376C>A	ENST00000546530.1	-	6	651	c.366G>T	c.(364-366)ctG>ctT	p.L122L	RASAL1_ENST00000261729.5_Silent_p.L122L|RASAL1_ENST00000446861.3_Silent_p.L122L|RASAL1_ENST00000548055.1_Silent_p.L122L|RASAL1_ENST00000418411.2_5'UTR	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	122	C2 2.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						TCTGCACTGACAGGCAGATCT	0.567000													45	41					1.6237e-14	1.77592e-14	1	1	0
NMD3	51068	broad.mit.edu	37	3	160942823	160942823	+	Silent	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr3:160942823C>T	ENST00000460469.1	+	2	605	c.150C>T	c.(148-150)gtC>gtT	p.V50V	NMD3_ENST00000351193.2_Silent_p.V50V|NMD3_ENST00000472947.1_Silent_p.V50V|NMD3_ENST00000478160.1_Intron			Q96D46	NMD3_HUMAN	NMD3 ribosome export adaptor	50					protein transport	cytoplasm|nucleolus|nucleoplasm				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(10)|ovary(1)|skin(1)|urinary_tract(2)	25			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			CGAAACAAGTCTCGATTTCGT	0.418000													57	130					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951816	119951816	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr4:119951816C>A	ENST00000307142.4	+	4	2082	c.1886C>A	c.(1885-1887)cCt>cAt	p.P629H	SYNPO2_ENST00000429713.2_Missense_Mutation_p.P629H|SYNPO2_ENST00000434046.2_Missense_Mutation_p.P629H|SYNPO2_ENST00000448416.2_Intron	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	629	Pro-rich.					nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						ACTCCTCCCCCTGACGCCTTC	0.607000													57	24					1.70232e-10	1.84271e-10	1	1	0
RPL12P38	645688	broad.mit.edu	37	17	58512697	58512697	+	RNA	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr17:58512697G>A	ENST00000588627.1	-	0	660																											TCCGGCTTTGGAAAAGCAGGT	0.507000													19	19					0	0	1	0	0
SLC35F5	80255	broad.mit.edu	37	2	114482997	114482997	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr2:114482997T>C	ENST00000245680.2	-	12	1621	c.1208A>G	c.(1207-1209)aAt>aGt	p.N403S	SLC35F5_ENST00000470204.2_5'UTR	NM_025181.2	NP_079457.2	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	403					transport	integral to membrane				endometrium(1)|kidney(4)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)	20						AATAAGGCCATTAATGATAAT	0.338000													58	47					0	0	1	0	0
FARS2	10667	broad.mit.edu	37	6	5613479	5613479	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr6:5613479C>G	ENST00000324331.6	+	6	1479	c.1143C>G	c.(1141-1143)ttC>ttG	p.F381L	FARS2_ENST00000274680.4_Missense_Mutation_p.F381L			O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2, mitochondrial	381	FDX-ACB.				phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|prostate(1)|stomach(2)	15	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	AAAATGATTTCTATGACTTAG	0.383000													20	61					0	0	1	0	0
SLC25A6	293	broad.mit.edu	37	X	1506193	1506193	+	Missense_Mutation	SNP	T	T	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chrX:1506193T>A	ENST00000381401.5	-	3	1432	c.718A>T	c.(718-720)Atg>Ttg	p.M240L		NM_001636.3	NP_001627.2	P12236	ADT3_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	240					active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|upper_aerodigestive_tract(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	CCGGACTGCATCATCATGCGC	0.677000													35	23					0	0	1	0	0
ZNF783	100289678	broad.mit.edu	37	7	148978841	148978841	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr7:148978841C>A	ENST00000434415.1	+	6	1211	c.1048C>A	c.(1048-1050)Ccc>Acc	p.P350T	ZNF783_ENST00000489518.1_Intron	NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	350					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			GCGGGCATTCCCCTGCCCCGA	0.731000													5	4					0.0215528	0.0215528	1	1	0
IPO7	10527	broad.mit.edu	37	11	9455160	9455160	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr11:9455160C>T	ENST00000379719.3	+	17	2067	c.1925C>T	c.(1924-1926)aCt>aTt	p.T642I		NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	642					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		GTCATTGGTACTGTTTTACAA	0.348000													31	19					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	133602448	133602448	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr7:133602448A>G	ENST00000253861.4	+	13	2013	c.1984A>G	c.(1984-1986)Aaa>Gaa	p.K662E	EXOC4_ENST00000545148.1_Missense_Mutation_p.K272E|EXOC4_ENST00000539845.1_Missense_Mutation_p.K561E|EXOC4_ENST00000460346.1_3'UTR	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	662					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding	p.K662E(1)		NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				GGCTCAACCCAAACAGCTGAG	0.408000													47	77					0	0	1	0	0
ELP4	26610	broad.mit.edu	37	11	31541612	31541612	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr11:31541612T>A	ENST00000395934.2	+	2	240	c.233T>A	c.(232-234)tTa>tAa	p.L78*	ELP4_ENST00000379163.5_Nonsense_Mutation_p.L78*|ELP4_ENST00000350638.5_Nonsense_Mutation_p.L78*			Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	78					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding	p.L78*(1)		breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					GGTGGAGGTTTAGCCGTTGGA	0.348000													11	35					0	0	1	0	0
OR3A2	4995	broad.mit.edu	37	17	3182212	3182212	+	Silent	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr17:3182212G>A	ENST00000408891.2	-	1	56	c.18C>T	c.(16-18)ctC>ctT	p.L6L	RP11-64J4.2_ENST00000573491.1_RNA	NM_002551.3	NP_002542.3	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A, member 2	6					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CTGGCTCCATGAGTTTCTGTA	0.463000													41	45					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187504	152187504	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr1:152187504G>A	ENST00000368801.2	-	3	6676	c.6601C>T	c.(6601-6603)Cat>Tat	p.H2201Y	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2201					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGACCCATGTTGGCCGTGG	0.617000													64	1027					0	0	1	0	0
TUBB3	10381	broad.mit.edu	37	16	90001717	90001717	+	Silent	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr16:90001717G>A	ENST00000304984.5	+	3	2937	c.642G>A	c.(640-642)gtG>gtA	p.V214V	TUBB3_ENST00000556922.1_Silent_p.V633V|TUBB3_ENST00000554444.1_Silent_p.V214V|TUBB3_ENST00000555576.1_Intron|TUBB3_ENST00000315491.7_Silent_p.V286V			Q13509	TBB3_HUMAN	tubulin, beta 3 class III	286					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CCCTGACCGTGCCCGAGCTCA	0.697000													7	100					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1269522	1269522	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr3:1269522A>T	ENST00000446702.2	+	4	830	c.203A>T	c.(202-204)gAc>gTc	p.D68V	CNTN6_ENST00000539053.1_5'UTR|CNTN6_ENST00000350110.2_Missense_Mutation_p.D68V			Q9UQ52	CNTN6_HUMAN	contactin 6	68	Ig-like C2-type 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AATGGCACAGACATTGATTTT	0.363000													50	14					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46897149	46897149	+	Silent	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr11:46897149G>A	ENST00000378623.1	-	27	4025	c.3783C>T	c.(3781-3783)ctC>ctT	p.L1261L		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	1261					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		TATAGGAGTCGAGCAGGGTGA	0.567000													25	51					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118373938	118373938	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr11:118373938A>G	ENST00000534358.1	+	27	7354	c.7331A>G	c.(7330-7332)cAt>cGt	p.H2444R	KMT2A_ENST00000354520.4_Missense_Mutation_p.H2403R|KMT2A_ENST00000389506.5_Missense_Mutation_p.H2441R	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		AAAGAAAAGCATTCCAGTAAA	0.393000													27	60					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184049828	184049828	+	Silent	SNP	G	G	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr3:184049828G>T	ENST00000342981.4	+	31	4989	c.4575G>T	c.(4573-4575)gcG>gcT	p.A1525A	EIF4G1_ENST00000382330.3_Silent_p.A1531A|EIF4G1_ENST00000441154.1_Silent_p.A1361A|EIF4G1_ENST00000319274.6_Silent_p.A1524A|EIF4G1_ENST00000350481.5_Silent_p.A1360A|EIF4G1_ENST00000424196.1_Silent_p.A1531A|EIF4G1_ENST00000414031.1_Silent_p.A1484A|EIF4G1_ENST00000435046.2_Silent_p.A1328A|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000392537.2_Silent_p.A1437A|EIF4G1_ENST00000427845.1_Silent_p.A1438A|EIF4G1_ENST00000352767.3_Silent_p.A1531A|EIF4G1_ENST00000434061.2_Silent_p.A1329A|EIF4G1_ENST00000411531.1_Silent_p.A1485A|EIF4G1_ENST00000346169.2_Silent_p.A1524A	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	1524	EIF4A-binding.|W2.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGCTACAGGCGCTCTACGCCC	0.592000													24	88					9.86323e-18	1.10174e-17	1	1	0
TNXB	7148	broad.mit.edu	37	6	32063534	32063534	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr6:32063534C>A	ENST00000375244.3	-	3	2297	c.2096G>T	c.(2095-2097)cGg>cTg	p.R699L	TNXB_ENST00000375247.2_Missense_Mutation_p.R699L|TNXB_ENST00000479795.1_Missense_Mutation_p.R699L			P22105	TENX_HUMAN	tenascin XB	699	EGF-like 18.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CTGGCCTGCCCGGCACAGTTC	0.687000													24	15					1.85244e-09	1.98476e-09	1	1	0
RASA1	5921	broad.mit.edu	37	5	86676366	86676366	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr5:86676366C>T	ENST00000456692.2	+	20	2228	c.2113C>T	c.(2113-2115)Cag>Tag	p.Q705*	RASA1_ENST00000506290.1_Nonsense_Mutation_p.Q716*|RASA1_ENST00000512763.1_Nonsense_Mutation_p.Q715*|RASA1_ENST00000274376.6_Nonsense_Mutation_p.Q882*	NM_022650.2	NP_072179.1	P20936	RASA1_HUMAN	RAS p21 protein activator (GTPase activating protein) 1	882					cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding	p.Q882*(1)		NS(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(12)|lung(13)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	48		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		GAAATCTGTTCAGCATAAGTG	0.363000													57	20					0	0	1	0	0
PHC3	80012	broad.mit.edu	37	3	169831259	169831259	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr3:169831259G>C	ENST00000494943.1	-	11	2274	c.2206C>G	c.(2206-2208)Ctt>Gtt	p.L736V	PHC3_ENST00000467570.1_Missense_Mutation_p.L695V|PHC3_ENST00000495893.1_Missense_Mutation_p.L748V			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	736					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TTATCCAAAAGAGGCCGTTTT	0.363000													24	39					0	0	1	0	0
RNPEP	6051	broad.mit.edu	37	1	201972573	201972573	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr1:201972573A>T	ENST00000295640.4	+	9	1678	c.1635A>T	c.(1633-1635)aaA>aaT	p.K545N	RNPEP_ENST00000367286.3_Missense_Mutation_p.K506N|RP11-465N4.4_ENST00000419190.1_RNA|RNPEP_ENST00000471105.1_3'UTR	NM_020216.3	NP_064601.3	Q9H4A4	AMPB_HUMAN	arginyl aminopeptidase (aminopeptidase B)	545					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding	p.K545N(1)		breast(1)|endometrium(4)|large_intestine(4)|lung(6)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		TCCTCCAGAAATCCCCTCTCC	0.537000													17	29					0	0	1	0	0
STX19	415117	broad.mit.edu	37	3	93733420	93733420	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr3:93733420G>A	ENST00000315099.2	-	2	950	c.694C>T	c.(694-696)Ctt>Ttt	p.L232F	ARL13B_ENST00000539730.1_Intron|ARL13B_ENST00000486562.1_Intron|ARL13B_ENST00000394222.3_Intron|ARL13B_ENST00000303097.7_Intron|ARL13B_ENST00000471138.1_Intron|ARL13B_ENST00000535334.1_Intron	NM_001001850.2	NP_001001850.1	Q8N4C7	STX19_HUMAN	syntaxin 19	232	t-SNARE coiled-coil homology.				intracellular protein transport|vesicle-mediated transport	membrane	SNAP receptor activity			kidney(2)|large_intestine(2)|lung(4)|prostate(1)	9						TGAATGAAAAGATCCCTTAAA	0.318000													23	45					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113704016	113704016	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr9:113704016T>C	ENST00000374431.3	-	4	861	c.478A>G	c.(478-480)Agc>Ggc	p.S160G	LPAR1_ENST00000541779.1_Missense_Mutation_p.S161G|LPAR1_ENST00000538760.1_Missense_Mutation_p.S161G|LPAR1_ENST00000374430.2_Missense_Mutation_p.S160G|LPAR1_ENST00000358883.4_Missense_Mutation_p.S160G	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	160					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						CGCCGGTTGCTCATCCGTGTG	0.527000													75	82					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236228283	236228283	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr1:236228283C>A	ENST00000264187.6	-	1	179	c.97G>T	c.(97-99)Gag>Tag	p.E33*	NID1_ENST00000366595.3_Nonsense_Mutation_p.E33*	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	33				EL -> SS (in Ref. 2; CAA57709).	cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GGAAAGAGCTCCTGGCGGCTC	0.701000													4	5					0.00024832	0.000253142	1	1	0
JAK3	3718	broad.mit.edu	37	19	17951143	17951143	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr19:17951143A>T	ENST00000458235.1	-	9	1249	c.1150T>A	c.(1150-1152)Ttt>Att	p.F384I	JAK3_ENST00000534444.1_Missense_Mutation_p.F384I|JAK3_ENST00000526008.1_5'UTR|JAK3_ENST00000527670.1_Missense_Mutation_p.F384I	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	384	SH2; atypical.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.F384I(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						TTGATGGCAAAGTCCAGACTG	0.562000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								16	24					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409583	59409583	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr8:59409583G>A	ENST00000301645.3	-	3	625	c.488C>T	c.(487-489)aCc>aTc	p.T163I		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	163					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				CCAGGCAGCGGTCTTTGAGTT	0.483000									Neonatal Giant Cell Hepatitis				96	126					0	0	1	0	0
MYO1H	283446	broad.mit.edu	37	12	109876392	109876392	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr12:109876392A>G	ENST00000310903.5	+	23	2319	c.2213A>G	c.(2212-2214)cAa>cGa	p.Q738R	MYO1H_ENST00000431443.2_Missense_Mutation_p.Q748R			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						AAGGCAATCCAAAGGAGAAAG	0.522000													6	17					0	0	1	0	0
CROCCP3	114819	broad.mit.edu	37	1	16812970	16812970	+	RNA	DEL	C	C	-	rs150878633	by1000genomes	TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr1:16812970delC	ENST00000263511.4	-	0	1341					NR_023386.1																						TGCTGCTGGGCCAGGTCCTTC	0.647													2	4	---	---	---	---					
AQP12A	375318	broad.mit.edu	37	2	241631786	241631786	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr2:241631786delG	ENST00000429564.1	+	2	518	c.455delG	c.(454-456)acfs	p.S153fs	AQP12A_ENST00000337801.4_Frame_Shift_Del_p.S141fs			Q8IXF9	AQ12A_HUMAN	aquaporin 12A	141						integral to membrane	transporter activity			endometrium(2)|kidney(3)|large_intestine(2)|lung(7)	14		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		CAGAGCTGCAGCTCGGCCCTG	0.692													2	4	---	---	---	---					
CELSR3	1951	broad.mit.edu	37	3	48698278	48698281	+	Frame_Shift_Del	DEL	CTGT	CTGT	-			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr3:48698278_48698281delCTGT	ENST00000544264.1	-	1	2067_2070	c.1787_1790delACAG	c.(1786-1791)gcfs	p.DS596fs	CELSR3_ENST00000164024.4_Frame_Shift_Del_p.DS596fs			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	596	Cadherin 3.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding	p.D596fs*94(1)		NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCCAGTGAGGCTGTCGATGGCAAA	0.618													24	13	---	---	---	---					
ZPLD1	131368	broad.mit.edu	37	3	102176697	102176697	+	Splice_Site	DEL	C	C	-	rs140908535		TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr3:102176697delC	ENST00000306176.1	+	5	730	c.630_splice	c.e5+1	p.N210_splice	ZPLD1_ENST00000491959.1_Splice_Site_p.N194_splice|ZPLD1_ENST00000466937.1_Splice_Site_p.N194_splice	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	194	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						TCCTTTATAACGTAAGTTGAT	0.368													8	203	---	---	---	---					
SLC51A	200931	broad.mit.edu	37	3	195955100	195955102	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr3:195955100_195955102delCTG	ENST00000296327.5	+	5	686_688	c.477_479delCTG	c.(475-480)ccc>cc	p.PC159del		NM_152672.5	NP_689885.4			solute carrier family 51, alpha subunit																		ACACAGGCCCctgctgctgctgc	0.665													7	220	---	---	---	---					
FBXW7	55294	broad.mit.edu	37	4	153253749	153253750	+	Splice_Site	INS	-	-	T			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr4:153253749_153253750insT	ENST00000281708.4	-	6	2212_2213	c.985_splice	c.e6+1	p.G328_splice	FBXW7_ENST00000393956.3_Splice_Site_p.G152_splice|FBXW7_ENST00000263981.5_Splice_Site_p.G248_splice|FBXW7_ENST00000603548.1_Splice_Site_p.G328_splice|FBXW7_ENST00000296555.5_Splice_Site_p.G210_splice|FBXW7_ENST00000603841.1_Splice_Site_p.G328_splice	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	328					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.I330fs*2(2)|p.I91fs*2(1)|p.?(1)|p.I250fs*2(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GAACCTTACCCTCTTCTTTGCA	0.366			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								27	9	---	---	---	---					
DPY19L2P2	349152	broad.mit.edu	37	7	102883498	102883498	+	RNA	DEL	A	A	-			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr7:102883498delA	ENST00000312132.4	-	0	2616																											GTACCACTGTAAAAAAAAAAA	0.284													3	5	---	---	---	---					
RBMS2	5939	broad.mit.edu	37	12	56975859	56975860	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr12:56975859_56975860insA	ENST00000262031.5	+	9	891_892	c.796_797insA	c.(796-798)taafs	p.*266fs	RBMS2_ENST00000550726.1_Frame_Shift_Ins_p.*141fs|RBMS2_ENST00000542360.1_Frame_Shift_Ins_p.*121fs|RBMS2_ENST00000552247.2_Frame_Shift_Ins_p.*266fs	NM_002898.3	NP_002889.1	Q15434	RBMS2_HUMAN	RNA binding motif, single stranded interacting protein 2	266					RNA processing	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(3)|skin(2)|urinary_tract(1)	18						CCCAGCCCCCTATAACATCACC	0.510													56	156	---	---	---	---					
HERC2P9	440248	broad.mit.edu	37	15	28900348	28900348	+	RNA	DEL	G	G	-			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr15:28900348delG	ENST00000528584.1	+	0	14					NR_036443.1																						aaaaaaaaaagaaaaTAACAA	0.403													4	2	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7576862	7576863	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr17:7576862_7576863insA	ENST00000420246.2	-	9	1115_1116	c.983_984insT	c.(982-984)tacfs	p.Y328fs	TP53_ENST00000269305.4_Frame_Shift_Ins_p.Y328fs|TP53_ENST00000445888.2_Frame_Shift_Ins_p.Y328fs|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Frame_Shift_Ins_p.Y328fs|TP53_ENST00000359597.4_Frame_Shift_Ins_p.Y328fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	328	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		F -> L (in a sporadic cancer; somatic mutation).|F -> S (in sporadic cancers; somatic mutation).|F -> V (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.T329fs*8(3)|p.F328F(1)|p.T329fs*21(1)|p.F328S(1)|p.?(1)|p.F328fs*9(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTGAAGGGTGAAATATTCTCC	0.441		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			49	25	---	---	---	---					
SSTR2	6752	broad.mit.edu	37	17	71165779	71165779	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr17:71165779delC	ENST00000357585.2	+	2	690	c.321delC	c.(319-321)cafs	p.H107fs	RP11-143K11.5_ENST00000580671.1_RNA|SSTR2_ENST00000315332.2_Frame_Shift_Del_p.H107fs	NM_001050.2	NP_001041.1	P30874	SSR2_HUMAN	somatostatin receptor 2	107					digestion|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	PDZ domain binding|somatostatin receptor activity			endometrium(2)|large_intestine(5)|lung(2)|prostate(2)	11			LUSC - Lung squamous cell carcinoma(166;0.197)			CTCTGGTCCACTGGCCCTTTG	0.532													58	86	---	---	---	---					
ACPT	93650	broad.mit.edu	37	19	51293714	51293716	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr19:51293714_51293716delCTG	ENST00000270593.1	+	1	43_45	c.43_45delCTG	c.(43-45)del	p.L20del	ACPT_ENST00000270594.3_In_Frame_Del_p.L20del	NM_033068.2	NP_149059.1	Q9BZG2	PPAT_HUMAN	acid phosphatase, testicular	20						integral to membrane	acid phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(3)	11		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TGGACCTCTCctgctgctgctgc	0.709													2	4	---	---	---	---					
LIMK2	3985	broad.mit.edu	37	22	31663761	31663761	+	Splice_Site	DEL	G	G	-			TCGA-BB-8601-01A-11D-2394-08	TCGA-BB-8601-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	479b14f2-3dc4-4220-9831-8ddb453fce2c	5cd14cf8-7b80-41c9-8df6-21c42ee84fd6	g.chr22:31663761delG	ENST00000331728.4	+	10	1242		c.e10-1		LIMK2_ENST00000333611.4_Splice_Site|LIMK2_ENST00000340552.4_Splice_Site|LIMK2_ENST00000406516.1_Splice_Site|LIMK2_ENST00000444929.2_Splice_Site	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2							mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						CCCACCCCCAGGTGAAAGTGA	0.507													46	82	---	---	---	---					
