Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR12D2	26529	broad.mit.edu	37	6	29365004	29365004	+	Silent	SNP	C	C	G			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr6:29365004C>G	ENST00000383555.2	+	1	589	c.528C>G	c.(526-528)ctC>ctG	p.L176L	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						ATCATTTTCTCTGTGATATTA	0.483000													5	114					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18846419	18846419	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr16:18846419T>G	ENST00000446231.2	-	49	8537	c.8125A>C	c.(8125-8127)Acc>Ccc	p.T2709P	SMG1_ENST00000389467.3_Missense_Mutation_p.T2709P			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	2709					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						CGCTGCAGGGTCATTTCAGTG	0.443000													4	121					0	0	1	0	0
NCKAP1	10787	broad.mit.edu	37	2	183888621	183888621	+	Silent	SNP	T	T	C			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr2:183888621T>C	ENST00000360982.2	-	3	908	c.150A>G	c.(148-150)aaA>aaG	p.K50K	NCKAP1_ENST00000361354.3_Silent_p.K44K	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	44					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GATAGGATGGTTTTGCCTTGG	0.353000													5	109					0	0	1	0	0
OR7G2	390882	broad.mit.edu	37	19	9213904	9213904	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr19:9213904G>T	ENST00000305456.2	-	1	78	c.79C>A	c.(79-81)Caa>Aaa	p.Q27K		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	6					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						ATAGCTGTTTGGTTTCTCGCT	0.453000													3	59					6.4e-05	6.4e-05	1	1	0
HCAR3	8843	broad.mit.edu	37	12	123200861	123200861	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr12:123200861A>G	ENST00000528880.2	-	1	578	c.424T>C	c.(424-426)Tgg>Cgg	p.W142R	HCAR1_ENST00000356987.2_Intron	NM_006018.2	NP_006009.2	P49019	HCAR3_HUMAN	hydroxycarboxylic acid receptor 3	142						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	9					Mepenzolate(DB04843)|Niacin(DB00627)	GCTGCTGTCCAATTGGAGATC	0.542000													5	62					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82580167	82580167	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr7:82580167C>T	ENST00000423517.2	-	6	10074	c.9737G>A	c.(9736-9738)cGa>cAa	p.R3246Q	PCLO_ENST00000333891.8_Missense_Mutation_p.R3246Q	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3177	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.R3246L(2)|p.R3177L(1)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTCTTGTTCTCGGAACCTTTG	0.473000													7	92					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169122871	169122871	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr5:169122871G>A	ENST00000256935.8	+	10	988	c.908G>A	c.(907-909)gGc>gAc	p.G303D		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	303					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCCGGGTCGGCAAGATGGAT	0.463000													4	59					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr18:14513764C>T	ENST00000358970.5	-	10	1429	c.1430G>A	c.(1429-1431)cGg>cAg	p.R477Q		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	477								p.R477Q(12)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AAGTTGTTTCCGGGTATCATT	0.358000													3	30					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142479940	142479940	+	RNA	SNP	C	C	T	rs58649169	by1000genomes	TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr7:142479940C>T	ENST00000603901.1	+	0	72					NR_001296.3																						ATGACAAGATCGTTGGGGGCT	0.557000													3	32					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121647850	121647850	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr3:121647850C>G	ENST00000489711.1	+	16	1751	c.1363C>G	c.(1363-1365)Ctg>Gtg	p.L455V	SLC15A2_ENST00000465060.1_3'UTR|SLC15A2_ENST00000295605.2_Missense_Mutation_p.L424V	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	455					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CTATTCCAAACTGCACCTGAA	0.403000													4	106					0	0	1	0	0
CAP1	10487	broad.mit.edu	37	1	40535489	40535490	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr1:40535489_40535490insG	ENST00000372797.3	+	9	1497_1498	c.936_937insG	c.(934-939)aagagcfs	p.S313fs	CAP1_ENST00000372802.1_Frame_Shift_Ins_p.S312fs|CAP1_ENST00000372805.3_Frame_Shift_Ins_p.S313fs|CAP1_ENST00000340450.3_Frame_Shift_Ins_p.S312fs|CAP1_ENST00000372798.1_Frame_Shift_Ins_p.S312fs|CAP1_ENST00000372792.2_Frame_Shift_Ins_p.S313fs|CAP1_ENST00000479759.1_3'UTR	NM_001105530.1|NM_006367.3	NP_001099000.1|NP_006358.1	Q01518	CAP1_HUMAN	CAP, adenylate cyclase-associated protein 1 (yeast)	313					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	12	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CATCCCCCAAACGAGCCACAAA	0.505													32	55	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7579441	7579453	+	Frame_Shift_Del	DEL	CGGTGTAGGAGCT	CGGTGTAGGAGCT	-			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr17:7579441_7579453delCGGTGTAGGAGCT	ENST00000420246.2	-	4	366_378	c.234_246delAGCTCCTACACCG	c.(232-246)gcfs	p.AAPTP78fs	TP53_ENST00000359597.4_Frame_Shift_Del_p.AAPTP78fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.AAPTP78fs|TP53_ENST00000413465.2_Frame_Shift_Del_p.AAPTP78fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.AAPTP78fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.AAPTP78fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	78	Interaction with HRMT1L2.|Interaction with WWOX.		A -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.P82L(8)|p.A76_S90del15(3)|p.G59fs*23(3)|p.T81I(2)|p.V73fs*9(1)|p.R65fs*38(1)|p.D48fs*55(1)|p.P80L(1)|p.A79V(1)|p.A79_A88del10(1)|p.P82fs*43(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.P82fs*67(1)|p.P80fs*41(1)|p.P82P(1)|p.P80fs*43(1)|p.A83fs*91(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGGGCCGCCGGTGTAGGAGCTGCTGGTGCAG	0.610		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	98	---	---	---	---					
