Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SERPINA10	51156	broad.mit.edu	37	14	94756570	94756570	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr14:94756570C>G	ENST00000554723.1	-	2	899	c.481G>C	c.(481-483)Gaa>Caa	p.E161Q	SERPINA10_ENST00000261994.4_Missense_Mutation_p.E121Q|SERPINA10_ENST00000554173.1_Missense_Mutation_p.E121Q|SERPINA10_ENST00000393096.1_Missense_Mutation_p.E121Q			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	121			T -> S (in dbSNP:rs2232700).		regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity	p.E121Q(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		ATCTGGGTTTCAGTCGGCCCT	0.592000													13	38					0	0	1	0	0
LRRC49	54839	broad.mit.edu	37	15	71276542	71276542	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr15:71276542A>C	ENST00000260382.5	+	11	1375	c.1115A>C	c.(1114-1116)cAg>cCg	p.Q372P	LRRC49_ENST00000560691.1_Missense_Mutation_p.Q78P|LRRC49_ENST00000443425.2_Missense_Mutation_p.Q328P|LRRC49_ENST00000560369.1_Missense_Mutation_p.Q377P|LRRC49_ENST00000436542.2_3'UTR|LRRC49_ENST00000560158.2_Missense_Mutation_p.Q60P|LRRC49_ENST00000544974.2_Missense_Mutation_p.Q362P	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	372						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						GACTCTCCTCAGGACCCCTGT	0.413000													6	88					0	0	1	0	0
MAP3K12	7786	broad.mit.edu	37	12	53876750	53876750	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr12:53876750G>T	ENST00000267079.2	-	12	1963	c.1738C>A	c.(1738-1740)Cta>Ata	p.L580I	MAP3K12_ENST00000547488.1_Missense_Mutation_p.L613I|MAP3K12_ENST00000547035.1_Missense_Mutation_p.L613I	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	580					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						CCCCCTCCTAGGCCCCCTGGG	0.662000													12	25					2.80697e-09	2.97709e-09	1	1	0
DCHS1	8642	broad.mit.edu	37	11	6654847	6654847	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr11:6654847G>A	ENST00000299441.3	-	5	2662	c.2251C>T	c.(2251-2253)Cgg>Tgg	p.R751W	RP11-732A19.6_ENST00000526633.1_RNA	NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	751	Cadherin 7.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R751W(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAATTGGCCCGTCTGGCCAAG	0.547000													3	5					0	0	1	0	0
CLASP1	23332	broad.mit.edu	37	2	122145474	122145474	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr2:122145474C>A	ENST00000263710.4	-	31	3521	c.3132G>T	c.(3130-3132)caG>caT	p.Q1044H	CLASP1_ENST00000409078.3_Missense_Mutation_p.Q1016H|CLASP1_ENST00000455322.2_Missense_Mutation_p.Q1039H|CLASP1_ENST00000397587.3_Missense_Mutation_p.Q1023H|CLASP1_ENST00000545861.1_Missense_Mutation_p.Q790H|CLASP1_ENST00000541377.1_Missense_Mutation_p.Q1022H|CLASP1_ENST00000541859.1_Missense_Mutation_p.Q800H	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	1044					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					TTAGCACAATCTGTGCTGCCT	0.333000													5	26					0.000602214	0.000616301	1	1	0
CNDP2	55748	broad.mit.edu	37	18	72167227	72167227	+	Silent	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr18:72167227C>T	ENST00000324262.4	+	2	335	c.19C>T	c.(19-21)Ctg>Ttg	p.L7L	CNDP2_ENST00000579847.1_Silent_p.L7L|CNDP2_ENST00000324301.8_Silent_p.L7L	NM_018235.2	NP_060705.2	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2 (metallopeptidase M20 family)	7						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(5)|ovary(2)|skin(2)|stomach(3)	24		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		CCTCACTACCCTGTTTAAGTA	0.453000													12	29					0	0	1	0	0
FAM186B	84070	broad.mit.edu	37	12	49992673	49992673	+	Silent	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr12:49992673G>A	ENST00000544141.1	-	5	2558	c.1959C>T	c.(1957-1959)gcC>gcT	p.A653A	FAM186B_ENST00000551047.1_Intron|FAM186B_ENST00000257894.2_Silent_p.A743A			Q8IYM0	F186B_HUMAN	family with sequence similarity 186, member B	743						protein complex				breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AGAGGTTCTGGGCCTTGTAGG	0.542000													13	65					0	0	1	0	0
GTF2F1	2962	broad.mit.edu	37	19	6380687	6380687	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr19:6380687C>T	ENST00000394456.5	-	12	1710	c.1246G>A	c.(1246-1248)Gag>Aag	p.E416K	GTF2F1_ENST00000429701.2_Missense_Mutation_p.E331K	NM_002096.2	NP_002087.2	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1, 74kDa	416					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)	16						GCAGGCATCTCGCTCACCCGC	0.652000													13	41					0	0	1	0	0
KDM1B	221656	broad.mit.edu	37	6	18160204	18160204	+	Silent	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr6:18160204C>T	ENST00000388870.2	+	3	319	c.78C>T	c.(76-78)tcC>tcT	p.S26S	KDM1B_ENST00000397244.1_Silent_p.S26S|KDM1B_ENST00000297792.5_Silent_p.S26S|KDM1B_ENST00000546309.2_Intron			Q8NB78	KDM1B_HUMAN	lysine (K)-specific demethylase 1B	26					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			breast(2)|endometrium(5)|large_intestine(6)|lung(8)|skin(3)|upper_aerodigestive_tract(1)	25						TGAGGAGCTCCGGTAGGCAGG	0.403000													7	19					0	0	1	0	0
MT1H	4496	broad.mit.edu	37	16	56704426	56704426	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr16:56704426T>C	ENST00000569155.1	+	2	82	c.37T>C	c.(37-39)Tgc>Cgc	p.C13R	MT1H_ENST00000332374.4_Missense_Mutation_p.C13R			P80294	MT1H_HUMAN	metallothionein 1H	13	Beta.						metal ion binding|protein binding			lung(5)	5						AGGTGGCTCCTGCGCCTGCGC	0.547000													11	34					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33575400	33575400	+	Silent	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr20:33575400G>A	ENST00000262873.7	+	15	1406	c.1314G>A	c.(1312-1314)ggG>ggA	p.G438G		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	396	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TCAGCAGTGGGGACCTCCTCA	0.632000													5	99					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766065	77766065	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr8:77766065G>A	ENST00000521891.2	+	10	7356	c.6908G>A	c.(6907-6909)cGg>cAg	p.R2303Q	ZFHX4_ENST00000050961.6_Missense_Mutation_p.R2258Q|ZFHX4_ENST00000518282.1_Missense_Mutation_p.R2277Q|ZFHX4_ENST00000455469.2_Missense_Mutation_p.R2258Q	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2258						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTAATGAACGGTACATTCGA	0.383000										HNSCC(33;0.089)			17	41					0	0	1	0	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114533	27114533	+	Silent	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr6:27114533C>T	ENST00000396891.4	-	1	86	c.45G>A	c.(43-45)tcG>tcA	p.S15S	HIST1H2BK_ENST00000356950.1_Silent_p.S15S	NM_080593.2	NP_542160.1	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	15					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						CGGCTTTCTTCGAGCCCTTCT	0.577000													33	160					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	A	G	rs141732548	by1000genomes	TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr21:14414855A>G	ENST00000507941.1	+	0	95																											GCCAATGGCCATGCAGAAGTA	0.448000													5	33					0	0	1	0	0
TCEAL7	56849	broad.mit.edu	37	X	102586458	102586458	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:102586458C>T	ENST00000332431.4	+	3	381	c.127C>T	c.(127-129)Cag>Tag	p.Q43*	TCEAL7_ENST00000372666.1_Nonsense_Mutation_p.Q43*	NM_152278.3	NP_689491.1	Q9BRU2	TCAL7_HUMAN	transcription elongation factor A (SII)-like 7	43					negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				endometrium(1)|upper_aerodigestive_tract(1)	2						gaggctgcttcagtctctcga	0.438000													23	42					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55534753	55534753	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:55534753C>T	ENST00000294383.6	-	68	7827	c.7828G>A	c.(7828-7830)Gag>Aag	p.E2610K	USP24_ENST00000407756.1_Missense_Mutation_p.E2450K	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	2610					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						CTTCTCAACTCACCAATCATC	0.438000													22	42					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11457183	11457183	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr7:11457183T>C	ENST00000423059.3	-	17	3682	c.3431A>G	c.(3430-3432)tAc>tGc	p.Y1144C	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1144	TSP type-1 11.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GTCACAGAGGTAATCCTCTAC	0.428000										HNSCC(18;0.044)			9	29					0	0	1	0	0
NOL8	55035	broad.mit.edu	37	9	95086373	95086373	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr9:95086373A>G	ENST00000545558.1	-	2	563	c.71T>C	c.(70-72)cTa>cCa	p.L24P	NOL8_ENST00000442668.2_Missense_Mutation_p.L24P|NOL8_ENST00000543985.1_5'UTR|NOL8_ENST00000542053.1_Intron|NOL8_ENST00000535387.1_Missense_Mutation_p.L24P|NOL8_ENST00000358855.4_5'UTR			Q76FK4	NOL8_HUMAN	nucleolar protein 8	24	RRM.				DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						CTGATTTTGTAGGTCTGCCTC	0.458000													53	50					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998101	27998101	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:27998101C>T	ENST00000441525.1	-	1	1465	c.1351G>A	c.(1351-1353)Gag>Aag	p.E451K		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	451										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						ACGACAAACTCACTCCGGGGG	0.458000													6	29					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25671519	25671519	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr13:25671519C>G	ENST00000281589.3	+	1	1220	c.1183C>G	c.(1183-1185)Cag>Gag	p.Q395E		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	395					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TGTGCCCAACCAGCGAGCACC	0.502000													9	74					0	0	1	0	0
CFP	5199	broad.mit.edu	37	X	47486637	47486637	+	Silent	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:47486637C>T	ENST00000247153.3	-	6	910	c.669G>A	c.(667-669)aaG>aaA	p.K223K	CFP_ENST00000396992.3_Silent_p.K223K|CFP_ENST00000377005.2_Silent_p.K223K	NM_002621.2	NP_002612.1	P27918	PROP_HUMAN	complement factor properdin	223	TSP type-1 3.				complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	18						GTGCAGAACACTTGCGGCTTC	0.692000													8	26					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6696667	6696667	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr19:6696667C>T	ENST00000245907.6	-	22	2892	c.2800G>A	c.(2800-2802)Gaa>Aaa	p.E934K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	934					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTGATTCCTTCCGGCTACGCA	0.577000													34	123					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													6	46					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50768911	50768911	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr20:50768911G>A	ENST00000216923.4	-	6	2169	c.1820C>T	c.(1819-1821)tCg>tTg	p.S607L	ZFP64_ENST00000371515.4_Missense_Mutation_p.S605L|ZFP64_ENST00000477786.1_Intron|ZFP64_ENST00000346617.4_Missense_Mutation_p.S553L|ZFP64_ENST00000371518.2_Intron|ZFP64_ENST00000361387.2_Intron	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	607					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						AGTAATACCCGAACTGGTAAT	0.562000													12	44					0	0	1	0	0
SLC35D3	340146	broad.mit.edu	37	6	137243653	137243653	+	Silent	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr6:137243653C>G	ENST00000331858.4	+	1	252	c.87C>G	c.(85-87)ctC>ctG	p.L29L		NM_001008783.1	NP_001008783.1	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	29					carbohydrate transport	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	13	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		ACATCTTGCTCAAGTTCCTCA	0.692000													4	22					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9577328	9577328	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr19:9577328C>A	ENST00000301480.4	-	10	2508	c.2295G>T	c.(2293-2295)gaG>gaT	p.E765D		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	765					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						CAAAGGGTTTCTCTCCCATAT	0.438000													24	72					1.85244e-09	1.98882e-09	1	1	0
PNMA2	10687	broad.mit.edu	37	8	26366057	26366057	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr8:26366057T>G	ENST00000522362.2	-	3	1109	c.215A>C	c.(214-216)gAt>gCt	p.D72A		NM_007257.5	NP_009188.1	Q9UL42	PNMA2_HUMAN	paraneoplastic Ma antigen 2	72					apoptosis	nucleolus	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)	11		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		gacatcagtatcttccagaag	0.483000													24	36					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105263991	105263991	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr8:105263991A>C	ENST00000507740.1	+	22	3671	c.3435A>C	c.(3433-3435)agA>agC	p.R1145S	RIMS2_ENST00000262231.10_Missense_Mutation_p.R1170S|RIMS2_ENST00000436393.2_Missense_Mutation_p.R1349S|RIMS2_ENST00000406091.3_Missense_Mutation_p.R1331S|RIMS2_ENST00000339750.2_Missense_Mutation_p.R267S	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1393					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CTCTGACAAGAAGAGCTTCCC	0.428000										HNSCC(12;0.0054)			30	142					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18844766	18844766	+	RNA	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr22:18844766G>A	ENST00000412938.1	+	0	3016																											CAGCCTCTGAGGGCAGCAGTG	0.557000													4	7					0	0	1	0	0
ENTPD6	955	broad.mit.edu	37	20	25205869	25205869	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr20:25205869G>A	ENST00000433259.2	+	13	1339	c.1213G>A	c.(1213-1215)Gag>Aag	p.E405K	ENTPD6_ENST00000376652.4_Silent_p.Q424Q|ENTPD6_ENST00000360031.2_Silent_p.Q423Q|ENTPD6_ENST00000354989.5_Silent_p.Q407Q|ENTPD6_ENST00000485936.1_3'UTR			O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6 (putative)	0						Golgi membrane|integral to membrane	nucleoside-diphosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|prostate(1)|skin(1)	27						CACAGCCGCAGAGCAGCCCCT	0.627000													7	24					0	0	1	0	0
AMACR	23600	broad.mit.edu	37	5	34007993	34007993	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr5:34007993G>C	ENST00000335606.6	-	1	220	c.132C>G	c.(130-132)agC>agG	p.S44R	AMACR_ENST00000502637.1_Missense_Mutation_p.S44R|AMACR_ENST00000382072.2_Missense_Mutation_p.S44R|AMACR_ENST00000514195.1_5'UTR|AMACR_ENST00000441713.2_Missense_Mutation_p.S44R|AMACR_ENST00000382085.3_Missense_Mutation_p.S44R	NM_001167595.1|NM_014324.5	NP_001161067.1|NP_055139.4	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase	44					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	19						GGCCCAAGCGGCTCACGTCGT	0.721000													4	12					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197898183	197898183	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:197898183G>T	ENST00000367390.3	+	6	988	c.961G>T	c.(961-963)Gag>Tag	p.E321*	LHX9_ENST00000367391.1_Intron|LHX9_ENST00000367387.4_Nonsense_Mutation_p.E330*|LHX9_ENST00000337020.2_Intron|LHX9_ENST00000561173.1_Intron	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	330					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						TTTGCGGCAGGAGAATGGGGG	0.512000													14	58					1.05317e-09	1.13768e-09	1	1	0
CRAMP1L	57585	broad.mit.edu	37	16	1706889	1706889	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr16:1706889G>A	ENST00000397412.3	+	10	2230	c.2131G>A	c.(2131-2133)Ggc>Agc	p.G711S	CRAMP1L_ENST00000436138.3_Missense_Mutation_p.G708S|CRAMP1L_ENST00000262317.4_Missense_Mutation_p.G89S|CRAMP1L_ENST00000293925.5_Missense_Mutation_p.G711S|LA16c-431H6.6_ENST00000454337.1_3'UTR			Q96RY5	CRML_HUMAN	Crm, cramped-like (Drosophila)	711						nucleus	DNA binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)	22						GCTGGGGCCCGGCCGCCAGGA	0.662000													3	1					0	0	1	0	0
AMY2A	279	broad.mit.edu	37	1	104160597	104160597	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:104160597G>A	ENST00000414303.2	+	2	254	c.190G>A	c.(190-192)Gtt>Att	p.V64I		NM_000699.2	NP_000690.1	P04746	AMYP_HUMAN	amylase, alpha 2A (pancreatic)	64					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			endometrium(3)|kidney(1)|large_intestine(5)|liver(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	AAATGAAAATGTTGCAATTTA	0.333000													37	110					0	0	1	0	0
PRIM1	5557	broad.mit.edu	37	12	57135538	57135538	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr12:57135538T>C	ENST00000338193.6	-	8	868	c.832A>G	c.(832-834)Aga>Gga	p.R278G		NM_000946.2	NP_000937.1	P49642	PRI1_HUMAN	primase, DNA, polypeptide 1 (49kDa)	278					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	DNA primase activity|metal ion binding			kidney(1)|lung(6)|prostate(1)	8						ACCTGATATCTGCTGGCTACT	0.363000													55	159					0	0	1	0	0
SULT4A1	25830	broad.mit.edu	37	22	44237688	44237688	+	Silent	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr22:44237688G>A	ENST00000330884.4	-	2	414	c.294C>T	c.(292-294)atC>atT	p.I98I	SULT4A1_ENST00000540422.1_Intron|SULT4A1_ENST00000249130.5_Silent_p.I98I	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	98					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		GTACCTTGATGATGTCCAGGC	0.587000													38	65					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50052898	50052898	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:50052898G>A	ENST00000376042.1	+	6	2027	c.1729G>A	c.(1729-1731)Gag>Aag	p.E577K	CCNB3_ENST00000376038.1_Intron|CCNB3_ENST00000348603.2_Intron|CCNB3_ENST00000276014.7_Missense_Mutation_p.E577K			Q8WWL7	CCNB3_HUMAN	cyclin B3	577					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					CCCTACAACTGAGGAGACAGT	0.408000													15	24					0	0	1	0	0
TAZ	6901	broad.mit.edu	37	X	153648421	153648421	+	Silent	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:153648421C>T	ENST00000299328.5	+	8	923	c.634C>T	c.(634-636)Ctg>Ttg	p.L212L	TAZ_ENST00000369776.4_Silent_p.L143L|TAZ_ENST00000351413.4_Silent_p.L198L|TAZ_ENST00000498029.1_3'UTR|TAZ_ENST00000350743.4_Silent_p.L182L|TAZ_ENST00000369790.4_Silent_p.L168L	NM_000116.3	NP_000107.1	Q16635	TAZ_HUMAN	tafazzin	212					cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity			lung(1)	1	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CATCCTGCCCCTGTGGCATGT	0.637000													36	97					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120468088	120468088	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:120468088C>G	ENST00000256646.2	-	25	4570	c.4351G>C	c.(4351-4353)Gat>Cat	p.D1451H		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1451	Negative regulatory region (NRR).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCACCCCCATCCCACTGGCAG	0.592000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				20	76					0	0	1	0	0
CYP39A1	51302	broad.mit.edu	37	6	46518114	46518114	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr6:46518114G>A	ENST00000275016.2	-	12	1602	c.1399C>T	c.(1399-1401)Caa>Taa	p.Q467*		NM_016593.3	NP_057677.2	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A, polypeptide 1	467					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity		EIF3K/CYP39A1(2)	NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)	21						CATATTCTTTGTTTATATTCA	0.468000													10	28					0	0	1	0	0
TVP23C	201158	broad.mit.edu	37	17	15441469	15441469	+	Splice_Site	SNP	C	C	T	rs139351610	by1000genomes	TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr17:15441469C>T	ENST00000584811.1	-	7	1815		c.e7-2		TVP23C_ENST00000225576.3_Intron|TVP23C-CDRT4_ENST00000522212.2_Intron|TVP23C_ENST00000438826.3_Splice_Site|TVP23C_ENST00000428082.2_Splice_Site|TVP23C_ENST00000519970.1_Intron					trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)																		TCCAGTGTTCCGCAAAAGACA	0.393000													5	78					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108459049	108459049	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr10:108459049C>T	ENST00000263054.6	-	9	1343	c.1336G>A	c.(1336-1338)Gtc>Atc	p.V446I	SORCS1_ENST00000369698.1_5'UTR|SORCS1_ENST00000344440.6_Missense_Mutation_p.V446I	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	446						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GTGAAGTAGACACCACGTGTG	0.512000													18	54					0	0	1	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101627081	101627081	+	Silent	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr5:101627081G>A	ENST00000310954.6	-	2	871	c.585C>T	c.(583-585)ttC>ttT	p.F195F		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	195					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		ATTCTCCACTGAAAAATTGTG	0.358000													9	54					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8438760	8438760	+	Silent	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr17:8438760C>T	ENST00000360416.3	-	16	1977	c.1839G>A	c.(1837-1839)gtG>gtA	p.V613V	MYH10_ENST00000269243.4_Silent_p.V603V|MYH10_ENST00000396239.1_Silent_p.V603V|MYH10_ENST00000379980.4_Silent_p.V619V	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	603	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						AAAGGGTGGCCACGTTGTCAT	0.458000													14	55					0	0	1	0	0
THEMIS2	9473	broad.mit.edu	37	1	28211938	28211938	+	Missense_Mutation	SNP	G	G	A	rs147739833		TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:28211938G>A	ENST00000373921.3	+	5	1856	c.1852G>A	c.(1852-1854)Gct>Act	p.A618T	THEMIS2_ENST00000492877.1_3'UTR|THEMIS2_ENST00000373925.1_Missense_Mutation_p.R260H|THEMIS2_ENST00000373927.3_Missense_Mutation_p.R123H|THEMIS2_ENST00000328928.7_Missense_Mutation_p.A489T	NM_001105556.1	NP_001099026.1			thymocyte selection associated family member 2																		CCACAGGCCCGCTAAGCCCCA	0.592000													7	26					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13708257	13708257	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr5:13708257G>T	ENST00000265104.4	-	76	13417	c.13313C>A	c.(13312-13314)gCt>gAt	p.A4438D		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4438					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGGGATTCTAGCATCAAACAT	0.443000									Kartagener syndrome				60	148					8.72158e-25	9.97567e-25	1	1	0
KIAA1432	57589	broad.mit.edu	37	9	5762633	5762633	+	Silent	SNP	C	C	T	rs139982016	by1000genomes	TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr9:5762633C>T	ENST00000414202.2	+	18	2276	c.2085C>T	c.(2083-2085)gaC>gaT	p.D695D	KIAA1432_ENST00000449720.2_Silent_p.D579D|KIAA1432_ENST00000418622.3_Silent_p.D616D|KIAA1432_ENST00000251879.6_Silent_p.D695D|KIAA1432_ENST00000381532.2_Silent_p.D616D	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	695						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		GGGAGAAGGACAGTAACCCTA	0.433000													8	47					0	0	1	0	0
ZNF273	10793	broad.mit.edu	37	7	64388278	64388278	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr7:64388278C>T	ENST00000476120.1	+	4	643	c.572C>T	c.(571-573)tCa>tTa	p.S191L	ZNF273_ENST00000527278.1_3'UTR|ZNF273_ENST00000319636.5_Missense_Mutation_p.S126L	NM_021148.2	NP_066971.2	Q14593	ZN273_HUMAN	zinc finger protein 273	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Lung NSC(55;0.0295)|all_lung(88;0.0691)				CATAAATTCTCAAATTCAAAT	0.308000													15	43					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31022592	31022592	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr20:31022592C>T	ENST00000375687.4	+	13	2501	c.2077C>T	c.(2077-2079)Cga>Tga	p.R693*	ASXL1_ENST00000306058.5_Nonsense_Mutation_p.R688*	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	693					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.R693*(7)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						AGATCTACAGCGAACACAACT	0.592000			"""F, N, Mis"""		"""MDS, CMML"""								5	19					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72081809	72081809	+	RNA	SNP	T	T	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr7:72081809T>C	ENST00000438125.1	-	0	1246							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										GAACTTTCTCTGCAGTAGGTA	0.498000													5	60					0	0	1	0	0
SEL1L2	80343	broad.mit.edu	37	20	13846130	13846130	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr20:13846130A>G	ENST00000284951.5	-	16	1509	c.1435T>C	c.(1435-1437)Tgg>Cgg	p.W479R	SEL1L2_ENST00000378072.5_Intron|SEL1L2_ENST00000486903.1_Intron			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	479						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						TTCTCAGCCCAGTGGCCTAGT	0.433000													17	48					0	0	1	0	0
SSX3	10214	broad.mit.edu	37	X	48208993	48208993	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:48208993A>G	ENST00000376893.3	-	7	589	c.496T>C	c.(496-498)Tcc>Ccc	p.S166P	SSX3_ENST00000298396.2_Intron|SSX3_ENST00000376895.1_Intron			Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|large_intestine(1)|lung(9)	13						agtggtctggaaccgaacctg	0.413000													11	40					0	0	1	0	0
SPCS1	28972	broad.mit.edu	37	3	52740832	52740832	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr3:52740832C>A	ENST00000233025.7	+	3	731	c.321C>A	c.(319-321)taC>taA	p.Y107*	SPCS1_ENST00000602728.1_Nonsense_Mutation_p.Y40*|SPCS1_ENST00000423431.1_Nonsense_Mutation_p.Y18*	NM_014041.3	NP_054760.3	Q9Y6A9	SPCS1_HUMAN	signal peptidase complex subunit 1 homolog (S. cerevisiae)	107					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to endoplasmic reticulum membrane|microsome|signal peptidase complex	peptidase activity			kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	6				BRCA - Breast invasive adenocarcinoma(193;6.51e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)|OV - Ovarian serous cystadenocarcinoma(275;0.0469)		TCTACGGGTACGTGGCTGAAC	0.428000													47	92					6.31075e-24	7.17131e-24	1	1	0
GPR35	2859	broad.mit.edu	37	2	241570030	241570030	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr2:241570030G>T	ENST00000319838.5	+	6	1603	c.661G>T	c.(661-663)Gcc>Tcc	p.A221S	GPR35_ENST00000438013.2_Missense_Mutation_p.A252S|GPR35_ENST00000430267.1_Missense_Mutation_p.A221S|GPR35_ENST00000407714.1_Missense_Mutation_p.A221S|GPR35_ENST00000403859.1_Missense_Mutation_p.A221S	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	221						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		CATGGTCTGGGCCAACCTCCT	0.682000													5	61					0.014758	0.0149286	1	1	0
PCLO	27445	broad.mit.edu	37	7	82764134	82764134	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr7:82764134C>T	ENST00000423517.2	-	3	3069	c.2732G>A	c.(2731-2733)aGt>aAt	p.S911N	PCLO_ENST00000333891.8_Missense_Mutation_p.S911N	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	857	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ATCAGTAATACTTCCCAGATT	0.537000													30	101					0	0	1	0	0
ALDH3A2	224	broad.mit.edu	37	17	19554870	19554870	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr17:19554870A>G	ENST00000176643.6	+	2	610	c.164A>G	c.(163-165)aAt>aGt	p.N55S	ALDH3A2_ENST00000395575.2_Missense_Mutation_p.N55S|ALDH3A2_ENST00000339618.4_Missense_Mutation_p.N55S|ALDH3A2_ENST00000579855.1_Missense_Mutation_p.N55S|ALDH3A2_ENST00000581518.1_Missense_Mutation_p.N55S			P51648	AL3A2_HUMAN	aldehyde dehydrogenase 3 family, member A2	55					cellular aldehyde metabolic process|central nervous system development|epidermis development|lipid metabolic process|peripheral nervous system development	endoplasmic reticulum membrane|integral to membrane	3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|ovary(2)|prostate(1)	13	all_cancers(12;1.39e-05)|all_epithelial(12;0.00158)|Breast(13;0.245)				NADH(DB00157)	AGTGAATTCAATGTGTACAGT	0.398000													54	47					0	0	1	0	0
BACH1	571	broad.mit.edu	37	21	30723990	30723990	+	RNA	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr21:30723990C>G	ENST00000504298.1	+	0	36					NR_027655.1																						AAGAAGTGTTCCATACCATTC	0.433000													14	53					0	0	1	0	0
SPICE1	152185	broad.mit.edu	37	3	113172487	113172487	+	Silent	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr3:113172487C>T	ENST00000295872.4	-	14	2227	c.1968G>A	c.(1966-1968)ctG>ctA	p.L656L		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	656					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						CATTTGTTCTCAGCTGCTGCC	0.428000													28	91					0	0	1	0	0
SIRPB2	284759	broad.mit.edu	37	20	1457910	1457910	+	Missense_Mutation	SNP	C	C	A	rs6135048	by1000genomes	TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr20:1457910C>A	ENST00000537284.1	-	5	854	c.518G>T	c.(517-519)gGa>gTa	p.G173V	SIRPB2_ENST00000444444.1_Intron|SIRPB2_ENST00000359801.3_Intron|SIRPB2_ENST00000381630.1_3'UTR			Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2	0	Ig-like V-type 2.					integral to membrane				endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CTGCTCCCTTCCCATGACCAA	0.552000													4	57					0.000602214	0.000616301	1	1	0
LEPR	3953	broad.mit.edu	37	1	66102125	66102125	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:66102125G>T	ENST00000349533.6	+	20	3110	c.2925G>T	c.(2923-2925)gaG>gaT	p.E975D	LEPR_ENST00000406510.3_Missense_Mutation_p.E42D	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	975					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TAACCTATGAGGACGAAAGCC	0.418000													8	66					5.18039e-06	5.39624e-06	1	1	0
MED12	9968	broad.mit.edu	37	X	70351428	70351428	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:70351428C>A	ENST00000333646.6	+	29	4275	c.4076C>A	c.(4075-4077)tCt>tAt	p.S1359Y	MED12_ENST00000374102.1_Missense_Mutation_p.S1359Y|MED12_ENST00000478889.1_Intron|MED12_ENST00000374080.3_Missense_Mutation_p.S1359Y	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1359					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					ATGCGCCAGTCTTCCTTGGAG	0.552000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						18	48					2.35188e-11	2.57237e-11	1	1	0
ADCY8	114	broad.mit.edu	37	8	132051983	132051983	+	Silent	SNP	T	T	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr8:132051983T>G	ENST00000286355.5	-	1	2689	c.597A>C	c.(595-597)ctA>ctC	p.L199L	ADCY8_ENST00000377928.3_Silent_p.L199L	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	199					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GGCTCAAGTGTAGGACCAAGA	0.587000										HNSCC(32;0.087)			4	56					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927424	92927424	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:92927424C>G	ENST00000373079.3	-	1	1143	c.880G>C	c.(880-882)Gat>Cat	p.D294H	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	294					nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						CTTTTAAGATCTACACTGTCC	0.438000													25	85					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203652501	203652501	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:203652501T>A	ENST00000357681.5	+	2	1291	c.168T>A	c.(166-168)agT>agA	p.S56R	ATP2B4_ENST00000391954.2_Missense_Mutation_p.S56R|ATP2B4_ENST00000367218.3_Missense_Mutation_p.S56R|ATP2B4_ENST00000341360.2_Missense_Mutation_p.S56R|ATP2B4_ENST00000367219.3_Missense_Mutation_p.S56R	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	56					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ATCTCTGCAGTAGACTGAAAA	0.488000													26	86					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	rs121913279		TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr3:178952085A>G	ENST00000263967.3	+	21	3297	c.3140A>G	c.(3139-3141)cAt>cGt	p.H1047R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1387)|p.H1047L(194)|p.H1047P(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378000	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			22	116					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70389690	70389690	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:70389690G>A	ENST00000374051.3	+	7	2552	c.2230G>A	c.(2230-2232)Gca>Aca	p.A744T	NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000536169.1_Missense_Mutation_p.A724T|NLGN3_ENST00000358741.3_Missense_Mutation_p.A764T	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	764					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					GGAGGAGCTGGCAGCATTACA	0.687000													5	9					0	0	1	0	0
GPC6	10082	broad.mit.edu	37	13	95055334	95055334	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr13:95055334G>C	ENST00000377047.4	+	9	2146	c.1531G>C	c.(1531-1533)Gag>Cag	p.E511Q		NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	511						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				CACGGAGTTTGAGTTTGTCAC	0.567000													40	49					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92706316	92706316	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr15:92706316A>G	ENST00000318445.6	+	10	2298	c.2084A>G	c.(2083-2085)tAt>tGt	p.Y695C	RP11-152L20.3_ENST00000561674.1_RNA|RP11-24J19.1_ENST00000557683.1_RNA|SLCO3A1_ENST00000424469.2_Intron|SLCO3A1_ENST00000555549.1_3'UTR	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	695					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			AAGTTTATCTATAACCTGGAA	0.468000													25	67					0	0	1	0	0
KRT20	54474	broad.mit.edu	37	17	39036112	39036112	+	Missense_Mutation	SNP	G	G	A	rs147567550		TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr17:39036112G>A	ENST00000167588.3	-	5	912	c.871C>T	c.(871-873)Cgc>Tgc	p.R291C		NM_019010.2	NP_061883.1	P35900	K1C20_HUMAN	keratin 20	291	Coil 2.|Rod.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	14		Breast(137;0.000301)|Ovarian(249;0.15)				TGGGAGGTGCGTCTCAGCTCC	0.443000													21	46					0	0	1	0	0
TMEM218	219854	broad.mit.edu	37	11	124971137	124971137	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr11:124971137G>T	ENST00000455225.1	-	3	824	c.173C>A	c.(172-174)cCg>cAg	p.P58Q	TMEM218_ENST00000529583.1_Missense_Mutation_p.P58Q|TMEM218_ENST00000528724.1_Missense_Mutation_p.P84Q|TMEM218_ENST00000527271.1_Missense_Mutation_p.P58Q|TMEM218_ENST00000526175.1_Missense_Mutation_p.P58Q|TMEM218_ENST00000279968.4_Missense_Mutation_p.P58Q|TMEM218_ENST00000527766.1_Missense_Mutation_p.P58Q|TMEM218_ENST00000532407.1_Missense_Mutation_p.P58Q|TMEM218_ENST00000532156.1_Silent_p.P42P|TMEM218_ENST00000531909.1_Missense_Mutation_p.P58Q|TMEM218_ENST00000531262.1_5'UTR|TMEM218_ENST00000529609.1_Silent_p.P42P			A2RU14	TM218_HUMAN	transmembrane protein 218	58						integral to membrane				breast(1)|large_intestine(2)|lung(1)|prostate(1)	5						ACCAGCTCGCGGGAAAAGCAA	0.423000													12	19					4.36969e-10	4.74966e-10	1	1	0
SYNE1	23345	broad.mit.edu	37	6	152651578	152651578	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr6:152651578G>T	ENST00000367255.5	-	78	14843	c.14242C>A	c.(14242-14244)Cag>Aag	p.Q4748K	SYNE1_ENST00000265368.4_Missense_Mutation_p.Q4748K|SYNE1_ENST00000448038.1_Missense_Mutation_p.Q4677K|SYNE1_ENST00000423061.1_Missense_Mutation_p.Q4677K|SYNE1_ENST00000341594.5_Missense_Mutation_p.Q4495K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4748					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTGTCTGGCTGCCAAGGCTGA	0.522000										HNSCC(10;0.0054)			14	62					2.32078e-09	2.47645e-09	1	1	0
BAG5	9529	broad.mit.edu	37	14	104026912	104026912	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr14:104026912C>T	ENST00000445922.2	-	2	836	c.590G>A	c.(589-591)cGa>cAa	p.R197Q	BAG5_ENST00000337322.4_Missense_Mutation_p.R238Q|BAG5_ENST00000299204.4_Missense_Mutation_p.R197Q|RP11-894P9.2_ENST00000556332.1_RNA	NM_004873.3	NP_004864.1	Q9UL15	BAG5_HUMAN	BCL2-associated athanogene 5	197	BAG 3.				apoptosis|negative regulation of protein refolding|negative regulation of ubiquitin-protein ligase activity|neuron death|protein folding|regulation of inclusion body assembly	inclusion body|perinuclear region of cytoplasm	chaperone binding|ubiquitin protein ligase binding			endometrium(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	24		Melanoma(154;0.155)	Epithelial(46;0.144)			CAGGACCCCTCGGGCCTTGTT	0.532000													30	71					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651422	84651422	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr15:84651422A>T	ENST00000286744.5	+	21	3266	c.3042A>T	c.(3040-3042)gaA>gaT	p.E1014D	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.E1014D	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1014						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTATGAGGGAATATCCTGGGA	0.502000													25	58					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	482229	482229	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr5:482229C>T	ENST00000264938.3	-	8	1409	c.1400G>A	c.(1399-1401)aGg>aAg	p.R467K	SLC9A3_ENST00000514375.1_Missense_Mutation_p.R458K	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	467						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GTGCTCGCTCCTCTTCACCTT	0.701000													3	18					0	0	1	0	0
FBXW7	55294	broad.mit.edu	37	4	153332882	153332882	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr4:153332882G>C	ENST00000281708.4	-	2	1303	c.74C>G	c.(73-75)tCa>tGa	p.S25*	FBXW7_ENST00000603548.1_Nonsense_Mutation_p.S25*|FBXW7_ENST00000604872.1_Nonsense_Mutation_p.S25*|FBXW7_ENST00000603841.1_Nonsense_Mutation_p.S25*	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	25					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding			NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TACCTGGCTTGAGGAAGGGTT	0.493000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								22	30					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152737534	152737534	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr6:152737534G>A	ENST00000367255.5	-	41	6639	c.6038C>T	c.(6037-6039)gCt>gTt	p.A2013V	SYNE1_ENST00000265368.4_Missense_Mutation_p.A2013V|SYNE1_ENST00000448038.1_Missense_Mutation_p.A2020V|SYNE1_ENST00000423061.1_Missense_Mutation_p.A2020V|SYNE1_ENST00000341594.5_Missense_Mutation_p.A2050V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2013					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGCTGAAGAGCTTGGCGGGT	0.388000										HNSCC(10;0.0054)			59	188					0	0	1	0	0
RS1	6247	broad.mit.edu	37	X	18662615	18662615	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:18662615C>A	ENST00000379984.3	-	5	497	c.457G>T	c.(457-459)Gtg>Ttg	p.V153L	RS1_ENST00000476595.1_5'UTR|CDKL5_ENST00000379989.3_Intron|CDKL5_ENST00000379996.3_Intron	NM_000330.3	NP_000321.1	O15537	XLRS1_HUMAN	retinoschisin 1	153	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				cervix(1)|endometrium(4)|large_intestine(5)|lung(2)|ovary(2)|skin(1)	15	Hepatocellular(33;0.183)					CTGTACTGCACGCTGTACTTG	0.507000													32	89					4.74835e-14	5.29275e-14	1	1	0
ZNF341	84905	broad.mit.edu	37	20	32379181	32379181	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr20:32379181C>T	ENST00000375200.1	+	15	2788	c.2423C>T	c.(2422-2424)gCg>gTg	p.A808V	RP4-553F4.6_ENST00000439444.1_RNA|RP4-553F4.6_ENST00000443171.1_RNA|ZNF341_ENST00000342427.2_Missense_Mutation_p.A801V|RP4-553F4.6_ENST00000423074.1_RNA			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	808					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						GTGGGTGGTGCGGTGGGCGCG	0.701000													4	39					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767078	77767078	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr8:77767078G>A	ENST00000521891.2	+	10	8369	c.7921G>A	c.(7921-7923)Gaa>Aaa	p.E2641K	ZFHX4_ENST00000050961.6_Missense_Mutation_p.E2596K|ZFHX4_ENST00000518282.1_Missense_Mutation_p.E2615K|ZFHX4_ENST00000455469.2_Missense_Mutation_p.E2596K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2596						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TATTGCCCGCGAAGTCGGGCT	0.512000										HNSCC(33;0.089)			16	46					0	0	1	0	0
GOLGA6L17P	642402	broad.mit.edu	37	15	85053142	85053142	+	RNA	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr15:85053142C>T	ENST00000414190.2	-	0	310					NR_003246.2																						TTTTTCAATTCCTTGACCCGC	0.413000													4	10					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59210828	59210828	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr11:59210828T>A	ENST00000302030.2	+	1	212	c.187T>A	c.(187-189)Tac>Aac	p.Y63N		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						CACACCCATGTACTTCTTCCT	0.488000													36	103					0	0	1	0	0
SHC4	399694	broad.mit.edu	37	15	49255046	49255046	+	Missense_Mutation	SNP	G	G	A	rs142795434		TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr15:49255046G>A	ENST00000332408.4	-	1	595	c.167C>T	c.(166-168)cCg>cTg	p.P56L		NM_203349.3	NP_976224.3	Q6S5L8	SHC4_HUMAN	SHC (Src homology 2 domain containing) family, member 4	56	CH2.				intracellular signal transduction	cell junction|postsynaptic membrane				breast(1)|endometrium(2)|large_intestine(8)|lung(11)|ovary(3)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	29		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		GGGAGGCTGCGGCGAGCCCTT	0.667000													6	68					0	0	1	0	0
EEPD1	80820	broad.mit.edu	37	7	36194453	36194453	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr7:36194453G>A	ENST00000242108.4	+	2	1238	c.520G>A	c.(520-522)Gtt>Att	p.V174I	EEPD1_ENST00000534978.1_Missense_Mutation_p.V174I	NM_030636.2	NP_085139.2	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family domain containing 1	174					DNA repair		DNA binding			endometrium(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|skin(1)	18						CTTTCGCAGCGTTGAGGACCT	0.627000													7	44					0	0	1	0	0
TRPC1	7220	broad.mit.edu	37	3	142521123	142521123	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr3:142521123C>T	ENST00000273482.6	+	9	1983	c.1592C>T	c.(1591-1593)tCa>tTa	p.S531L	TRPC1_ENST00000476941.1_Missense_Mutation_p.S565L	NM_003304.4	NP_003295.1	P48995	TRPC1_HUMAN	transient receptor potential cation channel, subfamily C, member 1	565					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(2)|stomach(3)|urinary_tract(1)	37						GGATATACTTCAAAGGAGCAG	0.333000													14	66					0	0	1	0	0
ADSS	159	broad.mit.edu	37	1	244614999	244614999	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:244614999C>A	ENST00000366535.3	-	1	437	c.121G>T	c.(121-123)Gaa>Taa	p.E41*		NM_001126.3	NP_001117.2	P30520	PURA2_HUMAN	adenylosuccinate synthase	41	IMP binding (By similarity).				AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding	p.E41K(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	12	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	CCTTTGCCTTCGTCGCCCCAC	0.736000													7	13					0.0293803	0.0295492	1	1	0
IGHV1-69	28461	broad.mit.edu	37	14	107170006	107170006	+	RNA	SNP	G	G	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr14:107170006G>T	ENST00000390633.2	-	0	336																											TCGTGGATTTGTCCGCGGTAA	0.542000													58	277					4.17463e-26	4.80632e-26	1	1	0
ANKRD17	26057	broad.mit.edu	37	4	74010532	74010532	+	Silent	SNP	A	A	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr4:74010532A>C	ENST00000358602.4	-	11	2003	c.1887T>G	c.(1885-1887)ggT>ggG	p.G629G	ANKRD17_ENST00000330838.6_Silent_p.G629G|ANKRD17_ENST00000514252.1_5'UTR|ANKRD17_ENST00000509867.2_Silent_p.G516G	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	629					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GAGTTCTTCCACCTTCAGATT	0.303000													6	16					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8485931	8485931	+	Silent	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr9:8485931G>A	ENST00000381196.4	-	25	3429	c.2886C>T	c.(2884-2886)aaC>aaT	p.N962N	PTPRD_ENST00000540109.1_Silent_p.N962N|PTPRD_ENST00000360074.4_Silent_p.N949N|PTPRD_ENST00000358503.5_Silent_p.N940N|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Silent_p.N962N|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000537002.1_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	962	Fibronectin type-III 7.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.N962N(1)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GAAGGGGGATGTTGATATCCC	0.468000										TSP Lung(15;0.13)			9	104					0	0	1	0	0
TMEM60	85025	broad.mit.edu	37	7	77423688	77423688	+	Translation_Start_Site	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr7:77423688C>T	ENST00000257663.3	-	2	379	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_032936.3	NP_116325.1	Q9H2L4	TMM60_HUMAN	transmembrane protein 60	1						integral to membrane				endometrium(1)|large_intestine(1)|lung(2)	4						AGGACATTCTCATTTAAACAG	0.388000													13	36					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14107666	14107666	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:14107666G>T	ENST00000235372.7	+	8	4232	c.3376G>T	c.(3376-3378)Gtt>Ttt	p.V1126F	PRDM2_ENST00000343137.4_Missense_Mutation_p.V925F|PRDM2_ENST00000311066.5_Missense_Mutation_p.V1126F|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000413440.1_Missense_Mutation_p.V925F	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	1126						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GGATGTTGTTGTTCAGGAAAC	0.403000													24	82					1.22574e-08	1.29219e-08	1	1	0
USP34	9736	broad.mit.edu	37	2	61597522	61597522	+	Silent	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr2:61597522C>T	ENST00000398571.2	-	10	1261	c.1185G>A	c.(1183-1185)ttG>ttA	p.L395L		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	395					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			CCAAAAAATTCAAAATCACTT	0.328000													25	91					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102498	22102498	+	Silent	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr14:22102498C>T	ENST00000542433.1	-	1	598	c.501G>A	c.(499-501)ttG>ttA	p.L167L		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		GGCGGAAGGTCAAGGTGGCCT	0.562000													37	67					0	0	1	0	0
OR6C65	403282	broad.mit.edu	37	12	55795041	55795041	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr12:55795041G>A	ENST00000379665.2	+	1	828	c.729G>A	c.(727-729)atG>atA	p.M243I		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						CCTCCCATATGATTGTGGTTT	0.398000													30	88					0	0	1	0	0
GULP1	51454	broad.mit.edu	37	2	189387546	189387546	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr2:189387546A>T	ENST00000409580.1	+	6	868	c.154A>T	c.(154-156)Aaa>Taa	p.K52*	GULP1_ENST00000409805.1_Intron|GULP1_ENST00000359135.3_Nonsense_Mutation_p.K52*|GULP1_ENST00000409637.3_Nonsense_Mutation_p.K52*|GULP1_ENST00000479019.1_3'UTR|GULP1_ENST00000409830.1_Nonsense_Mutation_p.K52*|GULP1_ENST00000410051.1_Nonsense_Mutation_p.K52*|GULP1_ENST00000409609.1_Nonsense_Mutation_p.K52*|GULP1_ENST00000409843.1_Nonsense_Mutation_p.K52*			Q9UBP9	GULP1_HUMAN	GULP, engulfment adaptor PTB domain containing 1	52	PID.				apoptosis|lipid transport|phagocytosis, engulfment	cytoplasm|intracellular membrane-bounded organelle	signal transducer activity			endometrium(3)|large_intestine(2)|lung(5)|ovary(1)|skin(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0423)|Epithelial(96;0.158)			TGCTGTAAGGAAACTAAAGGT	0.403000													20	57					0	0	1	0	0
ZNF300P1	134466	broad.mit.edu	37	5	150311004	150311004	+	RNA	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr5:150311004C>G	ENST00000520773.1	-	0	2317																											AGTATGTATTCTCTGATGTAT	0.423000													11	17					0	0	1	0	0
CTTN	2017	broad.mit.edu	37	11	70282397	70282397	+	Silent	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr11:70282397C>T	ENST00000376561.3	+	19	1959	c.1788C>T	c.(1786-1788)atC>atT	p.I596I	CTTN_ENST00000346329.3_3'UTR|CTTN_ENST00000301843.8_3'UTR	NM_001184740.1	NP_001171669.1	Q14247	SRC8_HUMAN	cortactin	0						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		GGAAACTCATCTCCTTCCTGA	0.582000													271	54					0	0	1	0	0
TGFB2	7042	broad.mit.edu	37	1	218520231	218520231	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:218520231T>G	ENST00000366929.4	+	1	655	c.188T>G	c.(187-189)gTc>gGc	p.V63G	TGFB2_ENST00000366930.4_Missense_Mutation_p.V63G	NM_001135599.2	NP_001129071.1	P61812	TGFB2_HUMAN	transforming growth factor, beta 2	63					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding			breast(1)|endometrium(1)|large_intestine(11)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(1)	31				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		CCCGAGGAAGTCCCCCCGGAG	0.632000													24	51					0	0	1	0	0
MIR515-2	574465	broad.mit.edu	37	19	54188333	54188333	+	RNA	SNP	T	T	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr19:54188333T>C	ENST00000384883.1	+	0	71					NR_030184.1|NR_030187.1																						TTTTGGAGCGTTACTGTTTGA	0.423000													14	31					0	0	1	0	0
KDM5C	8242	broad.mit.edu	37	X	53230783	53230783	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:53230783C>A	ENST00000452825.3	-	12	2341	c.1809G>T	c.(1807-1809)atG>atT	p.M603I	KDM5C_ENST00000375379.3_Missense_Mutation_p.M670I|KDM5C_ENST00000375383.3_Missense_Mutation_p.M629I|KDM5C_ENST00000465402.1_5'UTR|KDM5C_ENST00000375401.3_Missense_Mutation_p.M670I|KDM5C_ENST00000404049.3_Missense_Mutation_p.M669I	NM_001146702.1	NP_001140174.1	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	670	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						CCATGATGAACATCTCCTTAT	0.557000			"""N, F, S"""		clear cell renal carcinoma								23	59					7.33628e-21	8.28289e-21	1	1	0
ZNF20	7568	broad.mit.edu	37	19	12243777	12243777	+	Silent	SNP	A	A	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr19:12243777A>C	ENST00000334213.5	-	4	1448	c.1224T>G	c.(1222-1224)tcT>tcG	p.S408S	ZNF625-ZNF20_ENST00000430024.1_3'UTR|ZNF20_ENST00000600335.1_Intron	NM_001203250.1|NM_021143.3	NP_001190179.1|NP_066966.2	P17024	ZNF20_HUMAN	zinc finger protein 20	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|lung(6)	8						TACGCAAGGAAGAAAAATACT	0.403000													8	59					0	0	1	0	0
ZXDB	158586	broad.mit.edu	37	X	57620826	57620826	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:57620826C>T	ENST00000374888.1	+	1	2558	c.2345C>T	c.(2344-2346)gCa>gTa	p.A782V		NM_007157.3	NP_009088.1	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	782					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(2)|skin(6)	27						CCCAATGCAGCAGGAAACCAT	0.453000													30	116					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32519946	32519946	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:32519946T>C	ENST00000357033.4	-	19	2512	c.2306A>G	c.(2305-2307)gAa>gGa	p.E769G	DMD_ENST00000378677.2_Missense_Mutation_p.E765G	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	769					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTCAGCTTTTTCTCGCTCTAT	0.418000													8	18					0	0	1	0	0
SAFB2	9667	broad.mit.edu	37	19	5622657	5622657	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr19:5622657C>T	ENST00000252542.4	-	1	334	c.70G>A	c.(70-72)Gag>Aag	p.E24K		NM_014649.2	NP_055464.1	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		GTCCCAGTCTCCGCAACGCCC	0.692000													3	6					0	0	1	0	0
ZNF578	147660	broad.mit.edu	37	19	53015266	53015266	+	Silent	SNP	T	T	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr19:53015266T>C	ENST00000421239.2	+	6	1876	c.1632T>C	c.(1630-1632)tgT>tgC	p.C544C	CTD-3099C6.5_ENST00000599143.1_RNA	NM_001099694.1	NP_001093164.1	Q96N58	ZN578_HUMAN	zinc finger protein 578	319					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding								GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		GTAAGGTTTGTGACAAGGCTT	0.393000													27	71					0	0	1	0	0
CRISP1	167	broad.mit.edu	37	6	49803038	49803038	+	Silent	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr6:49803038C>T	ENST00000335847.4	-	8	842	c.741G>A	c.(739-741)gaG>gaA	p.E247E	CRISP1_ENST00000329411.5_3'UTR|CRISP1_ENST00000355791.2_Silent_p.E247E|CRISP1_ENST00000505118.1_Silent_p.E247E|CRISP1_ENST00000536021.1_3'UTR|CRISP1_ENST00000507853.1_3'UTR	NM_001131.2	NP_001122.2	P54107	CRIS1_HUMAN	cysteine-rich secretory protein 1	247					fusion of sperm to egg plasma membrane	extracellular space				endometrium(1)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0358)					CCTATTTTATCTCAGTGTCAC	0.393000													32	127					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196879474	196879474	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:196879474G>A	ENST00000367416.2	+	6	997	c.860G>A	c.(859-861)aGa>aAa	p.R287K	CFHR4_ENST00000367418.1_Missense_Mutation_p.R41K|CFHR4_ENST00000251424.4_Intron|CFHR2_ENST00000367421.3_Intron	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						AATACGCGTAGACCATACTTT	0.343000													10	57					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54963106	54963106	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr12:54963106C>A	ENST00000243052.3	+	4	802	c.366C>A	c.(364-366)ttC>ttA	p.F122L	PDE1B_ENST00000550620.1_Missense_Mutation_p.F102L|PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Missense_Mutation_p.F81L	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	122					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						AGCCCAAGTTCCGAAGCATTG	0.647000													12	32					0.00010058	0.000104151	1	1	0
ZNF783	100289678	broad.mit.edu	37	7	148963814	148963814	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr7:148963814C>A	ENST00000434415.1	+	2	576	c.413C>A	c.(412-414)gCc>gAc	p.A138D		NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	138					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			AAGGGGGAGGCCCCCAAGGTA	0.652000													13	126					2.68362e-12	2.97236e-12	1	1	0
POLR2E	5434	broad.mit.edu	37	19	1091820	1091820	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr19:1091820G>A	ENST00000215587.7	-	3	602	c.319C>T	c.(319-321)Cag>Tag	p.Q107*	POLR2E_ENST00000585838.1_5'UTR|POLR2E_ENST00000586746.1_Nonsense_Mutation_p.Q107*			P19388	RPAB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	107					interspecies interaction between organisms|mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|skin(2)	11		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGCCCTGCTGCACCACGATG	0.652000													11	40					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198719713	198719713	+	Silent	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:198719713C>G	ENST00000367376.2	+	29	3330	c.3159C>G	c.(3157-3159)gtC>gtG	p.V1053V	PTPRC_ENST00000442510.2_Silent_p.V1055V|PTPRC_ENST00000594404.1_Silent_p.V892V|PTPRC_ENST00000352140.3_Silent_p.V1005V|PTPRC_ENST00000348564.6_Silent_p.V894V	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1053	Tyrosine-protein phosphatase 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						AAAGAAAAGTCAAAGTTATTG	0.398000													22	114					0	0	1	0	0
CDHR3	222256	broad.mit.edu	37	7	105664841	105664841	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr7:105664841T>A	ENST00000542731.1	+	15	2199	c.2091T>A	c.(2089-2091)taT>taA	p.Y697*	CDHR3_ENST00000317716.9_Nonsense_Mutation_p.Y697*|CDHR3_ENST00000470188.1_3'UTR|CDHR3_ENST00000343407.5_Missense_Mutation_p.S200T|CDHR3_ENST00000478080.1_Nonsense_Mutation_p.Y609*			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3	697					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						GGGTCACCTATCAGGTCCTGA	0.498000													4	20					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								5	72					0	0	1	0	0
HACL1	26061	broad.mit.edu	37	3	15637898	15637898	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr3:15637898T>C	ENST00000321169.5	-	3	587	c.220A>G	c.(220-222)Aca>Gca	p.T74A	HACL1_ENST00000456194.2_Missense_Mutation_p.T74A|HACL1_ENST00000435217.2_Intron|HACL1_ENST00000451445.2_Missense_Mutation_p.T74A|HACL1_ENST00000457447.2_Missense_Mutation_p.T74A	NM_012260.2	NP_036392.2	Q9UJ83	HACL1_HUMAN	2-hydroxyacyl-CoA lyase 1	74					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding			NS(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	16						TACCTGCTTGTCAGATATCCA	0.373000													12	17					0	0	1	0	0
DNAI1	27019	broad.mit.edu	37	9	34517452	34517452	+	Missense_Mutation	SNP	G	G	A	rs150107677		TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr9:34517452G>A	ENST00000242317.4	+	19	2159	c.1988G>A	c.(1987-1989)cGc>cAc	p.R663H		NM_012144.2	NP_036276.1	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	663					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity			autonomic_ganglia(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|prostate(1)|skin(2)|urinary_tract(1)	34	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		CCCAATTTGCGCAAGATGCCA	0.552000									Kartagener syndrome				5	43					0	0	1	0	0
NACAP1	83955	broad.mit.edu	37	8	102381677	102381677	+	RNA	SNP	G	G	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr8:102381677G>T	ENST00000419462.1	+	0	1089					NR_002182.1																						TAAGGATATAGAATTGGTCCT	0.408000													31	48					3.99451e-17	4.48102e-17	1	1	0
SCN3A	6328	broad.mit.edu	37	2	166003509	166003509	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr2:166003509C>G	ENST00000360093.3	-	12	1902	c.1411G>C	c.(1411-1413)Gat>Cat	p.D471H	SCN3A_ENST00000409101.3_Missense_Mutation_p.D471H|SCN3A_ENST00000283254.7_Missense_Mutation_p.D471H	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	471						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CCACTGAAATCTCTTGAAGCA	0.418000													16	51					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13606242	13606242	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr4:13606242G>C	ENST00000040738.5	-	10	2417	c.2282C>G	c.(2281-2283)tCt>tGt	p.S761C		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	761	Lys-rich.						DNA binding										TTTCTCAGAAGAGTGAAGCTC	0.343000													3	28					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155408358	155408358	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:155408358G>C	ENST00000368346.3	-	5	6227	c.5588C>G	c.(5587-5589)tCa>tGa	p.S1863*	ASH1L_ENST00000392403.3_Nonsense_Mutation_p.S1863*			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1863					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TGCTTGCATTGATACGACAGC	0.488000													26	130					0	0	1	0	0
TPH2	121278	broad.mit.edu	37	12	72366470	72366470	+	Silent	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr12:72366470C>G	ENST00000333850.3	+	6	921	c.780C>G	c.(778-780)ctC>ctG	p.L260L		NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	260					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity	p.L260L(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	TGCCTCAACTCGAAGATGTCT	0.438000													58	185					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52281983	52281983	+	Splice_Site	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:52281983C>T	ENST00000354831.7	-	13	1833		c.e13+1		NRD1_ENST00000352171.7_Splice_Site|NRD1_ENST00000544028.1_Splice_Site|NRD1_ENST00000539524.1_Splice_Site|NRD1_ENST00000485608.1_Splice_Site	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)						cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						TGAATACTTGCTTTTTCCTAA	0.323000													14	55					0	0	1	0	0
RNF10	9921	broad.mit.edu	37	12	121009002	121009002	+	Silent	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr12:121009002C>T	ENST00000325954.4	+	14	2511	c.2050C>T	c.(2050-2052)Ctg>Ttg	p.L684L	RNF10_ENST00000542701.1_Intron|RNF10_ENST00000413266.2_Silent_p.L689L	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	684					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGACTTTCTGCTGACCCCTCT	0.527000													18	49					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180057035	180057035	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr5:180057035G>A	ENST00000261937.6	-	5	662	c.584C>T	c.(583-585)aCg>aTg	p.T195M	FLT4_ENST00000393347.3_Missense_Mutation_p.T195M|FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000502649.1_Missense_Mutation_p.T195M	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	195	Ig-like C2-type 2.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CAGCAGTGGCGTGGACACGAG	0.627000													31	31					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142133018	142133018	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr3:142133018G>C	ENST00000264951.4	-	14	1669	c.1552C>G	c.(1552-1554)Ctt>Gtt	p.L518V	XRN1_ENST00000392981.2_Missense_Mutation_p.L518V	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	518					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						GCTGCTGGAAGTACAGCAAGA	0.378000													21	110					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151878682	151878682	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr7:151878682T>C	ENST00000355193.2	-	36	6481	c.6263A>G	c.(6262-6264)aAt>aGt	p.N2088S	KMT2C_ENST00000262189.6_Missense_Mutation_p.N2088S					lysine (K)-specific methyltransferase 2C																		ATTTGACTGATTATGAGAAAA	0.453000													12	46					0	0	1	0	0
PQLC1	80148	broad.mit.edu	37	18	77679290	77679290	+	Missense_Mutation	SNP	C	C	T	rs114579767	by1000genomes	TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr18:77679290C>T	ENST00000397778.2	-	5	684	c.502G>A	c.(502-504)Gcc>Acc	p.A168T	PQLC1_ENST00000409073.1_Missense_Mutation_p.A85T|PQLC1_ENST00000357575.4_Missense_Mutation_p.A150T|PQLC1_ENST00000590381.1_Intron	NM_025078.4	NP_079354.2	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1	168						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	9		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		ACAAACAGGGCGGAGTCAATG	0.637000													4	42					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145001012	145001012	+	Silent	SNP	T	T	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr8:145001012T>C	ENST00000322810.4	-	30	4564	c.4395A>G	c.(4393-4395)acA>acG	p.T1465T	PLEC_ENST00000354958.2_Silent_p.T1306T|PLEC_ENST00000356346.3_Silent_p.T1314T|PLEC_ENST00000357649.2_Silent_p.T1332T|PLEC_ENST00000398774.2_Silent_p.T1296T|PLEC_ENST00000345136.3_Silent_p.T1328T|PLEC_ENST00000527096.1_Silent_p.T1351T|PLEC_ENST00000354589.3_Silent_p.T1328T|PLEC_ENST00000436759.2_Silent_p.T1355T	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	1465	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GGCTCGTCAGTGTGGTCAGCT	0.627000													6	61					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36342482	36342482	+	Silent	SNP	G	G	A	rs114385015	byFrequency	TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr19:36342482G>A	ENST00000378910.5	-	2	150	c.151C>T	c.(151-153)Ctg>Ttg	p.L51L	NPHS1_ENST00000353632.6_Silent_p.L51L	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	51	Ig-like C2-type 1.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCACAACGCAGCTCCACTGAG	0.682000													5	30					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8436642	8436642	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr9:8436642T>G	ENST00000381196.4	-	32	4579	c.4036A>C	c.(4036-4038)Att>Ctt	p.I1346L	PTPRD_ENST00000540109.1_Missense_Mutation_p.I1346L|PTPRD_ENST00000360074.4_Missense_Mutation_p.I1333L|PTPRD_ENST00000358503.5_Missense_Mutation_p.I1324L|PTPRD_ENST00000486161.1_Missense_Mutation_p.I939L|PTPRD_ENST00000356435.5_Missense_Mutation_p.I1346L|PTPRD_ENST00000355233.5_Missense_Mutation_p.I940L|PTPRD_ENST00000397606.3_Missense_Mutation_p.I939L|PTPRD_ENST00000397611.3_Missense_Mutation_p.I936L|PTPRD_ENST00000397617.3_Missense_Mutation_p.I939L|PTPRD_ENST00000537002.1_Missense_Mutation_p.I936L	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1346					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AATCTTTCAATGTGGTCTGCA	0.348000										TSP Lung(15;0.13)			4	55					0	0	1	0	0
POU2F2	5452	broad.mit.edu	37	19	42600296	42600296	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr19:42600296C>T	ENST00000389341.5	-	8	619	c.553G>A	c.(553-555)Gag>Aag	p.E185K	POU2F2_ENST00000529067.1_Missense_Mutation_p.E185K|POU2F2_ENST00000526816.2_Missense_Mutation_p.E201K|POU2F2_ENST00000342301.4_Missense_Mutation_p.E201K|POU2F2_ENST00000560558.1_Missense_Mutation_p.E146K|POU2F2_ENST00000560398.1_Missense_Mutation_p.E207K|POU2F2_ENST00000533720.1_Missense_Mutation_p.E185K|POU2F2_ENST00000529952.1_Missense_Mutation_p.E201K	NM_001207025.2|NM_001247994.1|NM_002698.4	NP_001193954.1|NP_001234923.1|NP_002689.1	P09086	PO2F2_HUMAN	POU class 2 homeobox 2	201					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(69;0.059)				TCCAGCTCCTCCAGATCACTG	0.687000													10	16					0	0	1	0	0
RAVER2	55225	broad.mit.edu	37	1	65270776	65270776	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:65270776G>C	ENST00000294428.3	+	8	1477	c.1399G>C	c.(1399-1401)Gaa>Caa	p.E467Q	RAVER2_ENST00000430964.2_Intron|RAVER2_ENST00000371072.4_Missense_Mutation_p.E454Q			Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	467						cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						TCATCATGGAGAAGCACATAA	0.403000													8	33					0	0	1	0	0
PARP4	143	broad.mit.edu	37	13	25074496	25074496	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr13:25074496G>A	ENST00000381989.3	-	4	464	c.359C>T	c.(358-360)cCg>cTg	p.P120L		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	120					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		GGCACTGTCCGGGCATAGACC	0.393000													15	34					0	0	1	0	0
BAIAP3	8938	broad.mit.edu	37	16	1395034	1395034	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr16:1395034C>T	ENST00000324385.5	+	21	2137	c.1979C>T	c.(1978-1980)tCg>tTg	p.S660L	BAIAP3_ENST00000568887.1_Missense_Mutation_p.S597L|BAIAP3_ENST00000562208.1_Missense_Mutation_p.S602L|BAIAP3_ENST00000426824.3_Missense_Mutation_p.S625L|BAIAP3_ENST00000397488.2_Missense_Mutation_p.S642L|BAIAP3_ENST00000397489.1_Missense_Mutation_p.S642L|BAIAP3_ENST00000421665.2_Missense_Mutation_p.S589L	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	660					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				GAGGTGGCCTCGGGGCTCTTT	0.647000													20	46					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17450176	17450176	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr11:17450176C>T	ENST00000302539.4	-	13	1984	c.1859G>A	c.(1858-1860)cGt>cAt	p.R620H	ABCC8_ENST00000389817.3_Missense_Mutation_p.R620H	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	620			R -> C (in HHF1; dbSNP:rs58241708).		carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CTGCTCCTCACGGATCTCTGC	0.652000													13	29					0	0	1	0	0
TMEM60	85025	broad.mit.edu	37	7	77423609	77423609	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr7:77423609C>G	ENST00000257663.3	-	2	458	c.82G>C	c.(82-84)Gat>Cat	p.D28H		NM_032936.3	NP_116325.1	Q9H2L4	TMM60_HUMAN	transmembrane protein 60	28						integral to membrane				endometrium(1)|large_intestine(1)|lung(2)	4						GCTTTCTCATCCAGTTTCAAC	0.428000													15	36					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43524048	43524048	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr21:43524048C>G	ENST00000400427.1	+	9	1550	c.1154C>G	c.(1153-1155)tCt>tGt	p.S385C	UMODL1_ENST00000408910.2_Missense_Mutation_p.S457C|UMODL1_ENST00000408989.2_Missense_Mutation_p.S457C|C21orf128_ENST00000329015.2_Missense_Mutation_p.R62T|UMODL1_ENST00000400424.1_Missense_Mutation_p.S385C	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	457	Fibronectin type-III 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CAGATCGTGTCTCTCCAGGCG	0.602000													26	95					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76592387	76592387	+	Splice_Site	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr16:76592387G>A	ENST00000307431.8	+	25	4116	c.3730_splice	c.e25-1	p.G1244_splice	CNTNAP4_ENST00000377504.4_Splice_Site_p.G1196_splice|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000478060.1_Splice_Site_p.G1172_splice|RP11-58C22.1_ENST00000563764.1_Intron|CNTNAP4_ENST00000476707.1_Splice_Site_p.G1248_splice	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1245					cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CTCTCTCTAGGTCTGATAGCT	0.343000													12	29					0	0	1	0	0
FAM208A	23272	broad.mit.edu	37	3	56657518	56657518	+	Silent	SNP	T	T	C			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr3:56657518T>C	ENST00000431842.2	-	17	4173	c.3249A>G	c.(3247-3249)gtA>gtG	p.V1083V	FAM208A_ENST00000355628.5_Silent_p.V1459V|FAM208A_ENST00000493960.2_3'UTR|FAM208A_ENST00000485156.1_5'UTR	NM_015224.3	NP_056039.2	Q9UK61	CC063_HUMAN	family with sequence similarity 208, member A	1520										NS(1)|breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(11)|prostate(3)|skin(1)	32						AATTGCTGCATACTTCTATAT	0.358000													20	49					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1269102	1269102	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr11:1269102C>G	ENST00000447027.1	+	31	11059	c.11001C>G	c.(10999-11001)ttC>ttG	p.F3667L	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Missense_Mutation_p.F3664L			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3664	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCCGTGTGTTCTGCTGCAACT	0.602000													22	72					0	0	1	0	0
ZNF695	57116	broad.mit.edu	37	1	247151417	247151417	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:247151417A>T	ENST00000339986.7	-	4	547	c.400T>A	c.(400-402)Tgg>Agg	p.W134R	ZNF695_ENST00000487338.2_Intron|ZNF695_ENST00000498046.2_Intron	NM_020394.4	NP_065127.4	Q8IW36	ZN695_HUMAN	zinc finger protein 695	134					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TGCCCTTTCCACTCACCCACA	0.388000													63	243					0	0	1	0	0
ERAP2	64167	broad.mit.edu	37	5	96245440	96245440	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr5:96245440C>T	ENST00000437043.3	+	15	3037	c.2326C>T	c.(2326-2328)Cag>Tag	p.Q776*	CTD-2260A17.2_ENST00000501338.1_Intron|ERAP2_ENST00000379904.4_Nonsense_Mutation_p.Q731*	NM_001130140.1|NM_022350.3	NP_001123612.1|NP_071745.1	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	776					antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		ACTCTTCTCCCAGTGGATGGA	0.473000													10	37					0	0	1	0	0
ZNF28	7576	broad.mit.edu	37	19	53304912	53304912	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr19:53304912C>G	ENST00000594602.1	-	5	405	c.304G>C	c.(304-306)Gca>Cca	p.A102P	ZNF28_ENST00000438150.2_Silent_p.G9G|ZNF28_ENST00000414252.2_Silent_p.G9G|ZNF28_ENST00000339844.6_Splice_Site_p.A52_splice|ZNF28_ENST00000457749.2_Silent_p.G62G|ZNF28_ENST00000360272.4_Silent_p.G9G			P17035	ZNF28_HUMAN	zinc finger protein 28	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TATTGCCTTGCCCTGTTGAGA	0.378000													45	163					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25861686	25861686	+	Silent	SNP	C	C	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr10:25861686C>A	ENST00000376351.3	+	7	1982	c.1623C>A	c.(1621-1623)ctC>ctA	p.L541L		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	541						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						TTTGGTTTCTCATTGGCTGGA	0.453000													12	49					2.27111e-07	2.37991e-07	1	1	0
PCDHGA10	56106	broad.mit.edu	37	5	140794641	140794641	+	Silent	SNP	G	G	A			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr5:140794641G>A	ENST00000398610.2	+	1	1899	c.1899G>A	c.(1897-1899)gcG>gcA	p.A633A	PCDHGA8_ENST00000398604.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGCACGGCGCGAGCCCTGC	0.697000													8	81					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7348270	7348270	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr3:7348270C>G	ENST00000486284.1	+	4	1238	c.964C>G	c.(964-966)Cca>Gca	p.P322A	GRM7_ENST00000402647.2_Missense_Mutation_p.P322A|GRM7_ENST00000403881.1_Missense_Mutation_p.P322A|GRM7_ENST00000357716.4_Missense_Mutation_p.P322A|GRM7_ENST00000389336.4_Missense_Mutation_p.P322A	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	322					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CAAAATAAACCCACTGCACCA	0.507000													19	51					0	0	1	0	0
NAA60	79903	broad.mit.edu	37	16	3526325	3526325	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr16:3526325G>T	ENST00000407558.4	+	3	401	c.98G>T	c.(97-99)tGg>tTg	p.W33L	NAA60_ENST00000577013.1_Missense_Mutation_p.W33L|NAA60_ENST00000360862.5_Intron|NAA60_ENST00000572584.1_Missense_Mutation_p.W33L|LA16c-306E5.3_ENST00000574423.2_RNA|NAA60_ENST00000576916.1_Missense_Mutation_p.W33L|NAA60_ENST00000570819.1_Missense_Mutation_p.W33L|NAA60_ENST00000570551.1_Intron|LA16c-306E5.2_ENST00000575785.1_RNA|NAA60_ENST00000421765.3_Missense_Mutation_p.W33L|NAA60_ENST00000414063.2_Missense_Mutation_p.W33L|NAA60_ENST00000575076.1_Missense_Mutation_p.W33L|NAA60_ENST00000424546.2_Intron|NAA60_ENST00000572942.1_Missense_Mutation_p.W33L|NAA60_ENST00000573580.1_Intron	NM_001083601.1	NP_001077070.1	Q9H7X0	NAT15_HUMAN	N(alpha)-acetyltransferase 60, NatF catalytic subunit	33	N-acetyltransferase.						N-acetyltransferase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)	7						TGTGGCGACTGGTTCCCCATC	0.642000													6	16					0.00116845	0.00118883	1	1	0
FAM131A	131408	broad.mit.edu	37	3	184060002	184060002	+	Silent	SNP	C	C	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr3:184060002C>G	ENST00000310585.4	+	1	1745	c.381C>G	c.(379-381)ctC>ctG	p.L127L	FAM131A_ENST00000340957.5_Silent_p.L73L|FAM131A_ENST00000418281.1_Silent_p.L35L|FAM131A_ENST00000383847.2_Silent_p.L158L|FAM131A_ENST00000450976.1_Silent_p.L73L|FAM131A_ENST00000453072.1_Silent_p.L73L|EIF2B5_ENST00000444495.1_Intron			Q6UXB0	F131A_HUMAN	family with sequence similarity 131, member A	127						extracellular region				breast(1)|endometrium(1)|large_intestine(2)|lung(9)|skin(1)	14	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ATTCAGACCTCAGCGAGGGCG	0.542000													20	97					0	0	1	0	0
CHD1	1105	broad.mit.edu	37	5	98209410	98209410	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr5:98209410C>T	ENST00000284049.3	-	25	3607	c.3458G>A	c.(3457-3459)cGa>cAa	p.R1153Q		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1153					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	CTCAGCATCTCGAGCAATTGC	0.338000													13	38					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155307999	155308000	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr1:155307999_155308000insT	ENST00000368346.3	-	27	9337_9338	c.8698_8699insA	c.(8698-8700)agafs	p.R2900fs	ASH1L_ENST00000392403.3_Frame_Shift_Ins_p.R2895fs			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	2900					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding	p.T2895fs*44(1)		autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			ACTTTCCTCTGTTTTTTTTTCA	0.520													8	132	---	---	---	---					
MYRIP	25924	broad.mit.edu	37	3	40231499	40231500	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr3:40231499_40231500insG	ENST00000302541.6	+	10	1552_1553	c.1210_1211insG	c.(1210-1212)tgafs	p.*404fs	MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000425621.1_Frame_Shift_Ins_p.*404fs|MYRIP_ENST00000444716.1_Frame_Shift_Ins_p.*404fs|MYRIP_ENST00000539167.1_Frame_Shift_Ins_p.*217fs|MYRIP_ENST00000396217.3_Frame_Shift_Ins_p.*315fs	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	404	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		CTTTGACTGGAGTGAGGCCTTG	0.624													27	41	---	---	---	---					
KIAA0391	9692	broad.mit.edu	37	14	35592700	35592700	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr14:35592700delT	ENST00000557565.1	+	2	630	c.249delT	c.(247-249)cafs	p.H83fs	KIAA0391_ENST00000250377.7_5'UTR|KIAA0391_ENST00000534898.4_Frame_Shift_Del_p.H83fs|KIAA0391_ENST00000603588.1_Intron|KIAA0391_ENST00000604948.1_Intron|KIAA0391_ENST00000603544.1_Frame_Shift_Del_p.H83fs|KIAA0391_ENST00000321130.10_Frame_Shift_Del_p.H83fs|KIAA0391_ENST00000605870.1_Intron			O15091	MRRP3_HUMAN	KIAA0391	83					tRNA processing	mitochondrion				central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	14	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		CTGTTCCTCATTTTTTTTTAG	0.423													7	46	---	---	---	---					
GDPD3	79153	broad.mit.edu	37	16	30124660	30124662	+	Splice_Site	DEL	CCT	CCT	-			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr16:30124660_30124662delCCT	ENST00000406256.3	-	1	515_517	c.139_splice	c.e1+1	p.GG46_splice		NM_024307.2	NP_077283.2	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain containing 3	46	GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)	11						ACCCGGCTCACCTCCTCGGTGGG	0.640													11	330	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7577048	7577048	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr17:7577048delT	ENST00000420246.2	-	8	1022	c.890delA	c.(889-891)ccfs	p.H297fs	TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Frame_Shift_Del_p.H297fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.H297fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.H297fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.H297fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	297	Interaction with HIPK1 (By similarity).		H -> D (in a sporadic cancer; somatic mutation).|H -> N (in a sporadic cancer; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.?(2)|p.L265_K305del41(1)|p.H297P(1)|p.G293fs*1(1)|p.H297fs*48(1)|p.H296_S303delHHELPPGS(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGCAGCTCGTGGTGAGGCTC	0.567		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	33	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45247389	45247389	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr17:45247389delT	ENST00000066544.3	-	4	364	c.271delA	c.(271-273)tcfs	p.I91fs	CDC27_ENST00000531206.1_Frame_Shift_Del_p.I91fs|CDC27_ENST00000528748.1_5'UTR|CDC27_ENST00000446365.2_Frame_Shift_Del_p.I30fs|RP5-867C24.5_ENST00000572193.1_RNA|CDC27_ENST00000527547.1_Frame_Shift_Del_p.I91fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	91					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding	p.I91fs*54(1)		NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						CCAGATAAGATTTGTTCCCCT	0.323													7	96	---	---	---	---					
ADORA2A	135	broad.mit.edu	37	22	24829669	24829680	+	In_Frame_Del	DEL	CATTGACCGCTA	CATTGACCGCTA	-			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chr22:24829669_24829680delCATTGACCGCTA	ENST00000337539.7	+	2	756_767	c.297_308delCATTGACCGCTA	c.(295-309)gcc>gc	p.AIDRY99del	ADORA2A-AS1_ENST00000326341.4_RNA|ADORA2A_ENST00000496497.1_Intron|ADORA2A-AS1_ENST00000543438.1_RNA|KB-1896H10.1_ENST00000358654.2_3'UTR	NM_000675.4|NM_001278497.1|NM_001278498.1|NM_001278499.1|NM_001278500.1	NP_000666.2|NP_001265426.1|NP_001265427.1|NP_001265428.1|NP_001265429.1	P29274	AA2AR_HUMAN	adenosine A2a receptor	99					apoptosis|blood coagulation|cAMP biosynthetic process|cellular defense response|inflammatory response|nerve growth factor receptor signaling pathway|phagocytosis|sensory perception	integral to plasma membrane|membrane fraction	enzyme binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|skin(1)	21	Colorectal(2;0.196)				Caffeine(DB00201)|Defibrotide(DB04932)|Pegademase bovine(DB00061)|Theophylline(DB00277)	TGGCCATCGCCATTGACCGCTACATTGCCATC	0.627													14	59	---	---	---	---					
SLITRK2	84631	broad.mit.edu	37	X	144905535	144905535	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-A498-01A-11D-A24D-08	TCGA-CN-A498-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8a2708-1703-4c31-acbd-004ea132ded7	19c1570e-5804-473b-9f8d-e973e802a0fd	g.chrX:144905535delG	ENST00000370490.1	+	1	5847	c.1592delG	c.(1591-1593)tgfs	p.W531fs	SLITRK2_ENST00000413937.2_Frame_Shift_Del_p.W531fs|SLITRK2_ENST00000428560.2_Frame_Shift_Del_p.W531fs|SLITRK2_ENST00000447897.2_Frame_Shift_Del_p.W531fs|SLITRK2_ENST00000434188.2_Frame_Shift_Del_p.W531fs			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	531	LRRCT 2.					integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					GAGAACCCCTGGGACTGTACC	0.498													22	81	---	---	---	---					
