Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GNLY	10578	broad.mit.edu	37	2	85922485	85922485	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:85922485C>A	ENST00000409696.3	+	3	332	c.50C>A	c.(49-51)gCa>gAa	p.A17E	GNLY_ENST00000533041.1_3'UTR|GNLY_ENST00000263863.4_Missense_Mutation_p.A32E|GNLY_ENST00000524600.1_Missense_Mutation_p.A59E	NM_012483.2	NP_036615.2	P22749	GNLY_HUMAN	granulysin	32					cellular defense response|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(4)|kidney(10)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	19						TACGACCTGGCAAGAGCCCAC	0.622000													16	29					1.45105e-14	1.82948e-14	1	1	0
WSCD2	9671	broad.mit.edu	37	12	108589958	108589958	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:108589958G>T	ENST00000332082.4	+	3	1167	c.349G>T	c.(349-351)Ggg>Tgg	p.G117W	WSCD2_ENST00000261400.3_Missense_Mutation_p.G117W|WSCD2_ENST00000547525.1_Missense_Mutation_p.G117W|WSCD2_ENST00000549903.1_Missense_Mutation_p.G117W			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	117						integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						AGCCCTCAAGGGGAGGGTTGT	0.572000													18	30					3.52763e-06	3.85505e-06	1	1	0
ZZEF1	23140	broad.mit.edu	37	17	3912962	3912962	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:3912962C>T	ENST00000381638.2	-	53	8793	c.8669G>A	c.(8668-8670)gGc>gAc	p.G2890D		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	2890							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						AAGGAGGATGCCGGGCTGCGT	0.627000													4	108					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155711766	155711766	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:155711766A>G	ENST00000295101.2	+	3	1924	c.1447A>G	c.(1447-1449)Agg>Ggg	p.R483G		NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	483					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	AGGAGCAGCTAGGATGGAAGG	0.413000													9	17					0	0	1	0	0
PIAS2	9063	broad.mit.edu	37	18	44392405	44392405	+	Silent	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:44392405T>G	ENST00000585916.1	-	14	1856	c.1857A>C	c.(1855-1857)tcA>tcC	p.S619S		NM_004671.3	NP_004662.2	O75928	PIAS2_HUMAN	protein inhibitor of activated STAT, 2	619					androgen receptor signaling pathway|negative regulation of androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|PML body	androgen receptor binding|DNA binding|protein binding|SUMO ligase activity|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	22						TTTAGTCCAATGAGATGATGT	0.418000													10	7					0	0	1	0	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													4	111					0	0	1	0	0
CCDC11	220136	broad.mit.edu	37	18	47788587	47788587	+	Silent	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:47788587T>C	ENST00000398545.4	-	2	189	c.72A>G	c.(70-72)agA>agG	p.R24R		NM_145020.3	NP_659457.2	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	24										endometrium(1)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|pancreas(1)|skin(1)	20				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		GAGGCTTGGATCTCTGAAAAC	0.368000													17	20					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121747727	121747727	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:121747727G>C	ENST00000452319.1	+	14	4297	c.4237G>C	c.(4237-4239)Gca>Cca	p.A1413P	GLI2_ENST00000314490.11_Intron|GLI2_ENST00000361492.4_Missense_Mutation_p.A1413P			P10070	GLI2_HUMAN	GLI family zinc finger 2	1413					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				TCAGGAAACAGCAGAGGCTGT	0.687000													20	40					0	0	1	0	0
CHST13	166012	broad.mit.edu	37	3	126261332	126261332	+	Missense_Mutation	SNP	C	C	G	rs148180435		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:126261332C>G	ENST00000319340.2	+	3	987	c.937C>G	c.(937-939)Ccc>Gcc	p.P313A		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	313					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		GGACATCAGCCCCTTCTACCA	0.697000													4	17					0	0	1	0	0
SFMBT2	57713	broad.mit.edu	37	10	7205850	7205850	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:7205850A>T	ENST00000361972.4	-	21	2657	c.2567T>A	c.(2566-2568)cTg>cAg	p.L856Q	SFMBT2_ENST00000397167.1_Missense_Mutation_p.L856Q	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	856	SAM.				regulation of transcription, DNA-dependent	nucleus				NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						GGTCAGAAGCAGGAGTGCTTG	0.557000													17	54					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48719886	48719886	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:48719886G>T	ENST00000316623.5	-	58	7537	c.7082C>A	c.(7081-7083)tCg>tAg	p.S2361*		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2361	TB 9.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GCAGCATTCCGATTTGGTGAC	0.552000													23	33					1.10513e-12	1.34458e-12	1	1	0
GDNF	2668	broad.mit.edu	37	5	37815944	37815944	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:37815944A>G	ENST00000326524.2	-	3	644	c.445T>C	c.(445-447)Tgc>Cgc	p.C149R	GDNF_ENST00000515058.1_Missense_Mutation_p.C123R|GDNF_ENST00000427982.1_Missense_Mutation_p.C166R|GDNF_ENST00000381826.4_Missense_Mutation_p.C140R|GDNF_ENST00000344622.4_Missense_Mutation_p.C123R	NM_000514.3	NP_000505.1	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor	149					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity			NS(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(8)|skin(2)	15	all_lung(31;0.00118)					GCTGCATCGCAAGAGCCGCTG	0.453000													23	179					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126412471	126412471	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:126412471G>T	ENST00000394329.3	+	17	14507	c.14494G>T	c.(14494-14496)Ggc>Tgc	p.G4832C	FAT4_ENST00000335110.5_Missense_Mutation_p.G3073C	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4832					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TCCAGCGGATGGCATTCCAGC	0.483000													26	79					3.28513e-13	4.02373e-13	1	1	0
ANO7	50636	broad.mit.edu	37	2	242135264	242135264	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:242135264C>T	ENST00000402530.3	+	4	575	c.472C>T	c.(472-474)Cgt>Tgt	p.R158C	ANO7_ENST00000274979.8_Intron|ANO7_ENST00000402430.3_Intron	NM_001001666.3	NP_001001666.1	Q6IWH7	ANO7_HUMAN	anoctamin 7	0						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						AGACCAGGTACGTGGAGGCTG	0.617000													37	59					0	0	1	0	0
RCAN2	10231	broad.mit.edu	37	6	46190881	46190881	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:46190881G>A	ENST00000371374.1	-	5	920	c.729C>T	c.(727-729)aaC>aaT	p.N243N	RCAN2_ENST00000405162.1_Silent_p.N243N|RCAN2_ENST00000306764.7_Silent_p.N243N|RCAN2_ENST00000330430.6_Silent_p.N197N	NM_001251974.1	NP_001238903.1	Q14206	RCAN2_HUMAN	regulator of calcineurin 2	197					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding	p.N197K(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						AGGCAGCTCAGTTGGACACGG	0.483000													65	100					0	0	1	0	0
VPRBP	9730	broad.mit.edu	37	3	51458118	51458118	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:51458118C>G	ENST00000335891.5	-	7	968	c.959G>C	c.(958-960)aGc>aCc	p.S320T				Q9Y4B6	VPRBP_HUMAN	Vpr (HIV-1) binding protein	769					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		CCGGACAGTGCTACTGCGAGA	0.562000													58	39					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24877399	24877399	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:24877399G>A	ENST00000382554.3	+	3	841	c.523G>A	c.(523-525)Gca>Aca	p.A175T		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	175					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TGACCAGCATGCAGGGGACCT	0.697000													7	11					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152277643	152277643	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:152277643C>T	ENST00000368799.1	-	3	9754	c.9719G>A	c.(9718-9720)cGt>cAt	p.R3240H	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3240	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.R3240H(2)		autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AACAGATCCACGATGGTTTCT	0.587000									Ichthyosis				163	274					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177245544	177245544	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:177245544C>T	ENST00000361539.4	+	6	1298	c.986C>T	c.(985-987)aCt>aTt	p.T329I	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		329						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						TCCTGGGCCACTCACAACCGG	0.562000													9	47					0	0	1	0	0
MAGEB18	286514	broad.mit.edu	37	X	26158077	26158077	+	Silent	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:26158077T>C	ENST00000325250.1	+	2	1162	c.975T>C	c.(973-975)gcT>gcC	p.A325A		NM_173699.3	NP_775970.1	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	325							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(17)|skin(2)|stomach(1)|urinary_tract(2)	33						CTCATACTGCTGCCATGGCAA	0.512000													8	2					0	0	1	0	0
MYEF2	50804	broad.mit.edu	37	15	48443709	48443709	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:48443709C>A	ENST00000324324.7	-	13	1546	c.1267G>T	c.(1267-1269)Gga>Tga	p.G423*	MYEF2_ENST00000267836.6_Nonsense_Mutation_p.G423*	NM_016132.3	NP_057216.2	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	423	Gly-rich.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		TGATTTATTCCAATATCACCA	0.383000													160	309					1.1324e-67	1.70796e-67	1	1	0
SLC14A2	8170	broad.mit.edu	37	18	43204711	43204711	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:43204711C>A	ENST00000255226.6	+	2	898	c.82C>A	c.(82-84)Ccg>Acg	p.P28T	SLC14A2_ENST00000586448.1_Missense_Mutation_p.P28T	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	28						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GTTTACCAGCCCGAGCTGGCC	0.572000													48	25					8.86878e-18	1.16652e-17	1	1	0
GIT1	28964	broad.mit.edu	37	17	27903557	27903557	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:27903557G>A	ENST00000225394.3	-	13	1611	c.1363C>T	c.(1363-1365)Cgg>Tgg	p.R455W	GIT1_ENST00000581348.1_Missense_Mutation_p.R464W|GIT1_ENST00000579937.1_Missense_Mutation_p.R455W|RP11-68I3.2_ENST00000581474.1_RNA|GIT1_ENST00000394869.3_Missense_Mutation_p.R464W	NM_014030.3	NP_054749.2	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 1	455					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding			large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		TGCAGCCTCCGGAGCTCGTCG	0.622000													37	74					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76024585	76024585	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:76024585C>T	ENST00000393004.2	-	5	1184	c.963G>A	c.(961-963)ctG>ctA	p.L321L	FILIP1_ENST00000370020.1_Silent_p.L222L|FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Silent_p.L321L			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	321										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						CTTGATTAGCCAGTTTAGCGT	0.423000													36	89					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54804027	54804027	+	Splice_Site	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:54804027A>T	ENST00000545554.1	+	23	5456	c.5457_splice	c.e23+1	p.E1819_splice	UNC13C_ENST00000537900.1_Splice_Site_p.E1817_splice|UNC13C_ENST00000260323.11_Splice_Site_p.E1819_splice			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1819					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGAGGGAAGGAGGTGGGTATC	0.353000													7	13					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133252047	133252047	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:133252047C>A	ENST00000320574.5	-	12	1206	c.1163G>T	c.(1162-1164)gGc>gTc	p.G388V	POLE_ENST00000535270.1_Missense_Mutation_p.G361V	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	388					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CTTCTGGAAGCCTATCTCCTG	0.612000								DNA polymerases (catalytic subunits)					29	81					2.65835e-16	3.45917e-16	1	1	0
ABCC5	10057	broad.mit.edu	37	3	183699570	183699570	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:183699570G>T	ENST00000334444.6	-	8	1332	c.1092C>A	c.(1090-1092)taC>taA	p.Y364*	ABCC5_ENST00000265586.6_Nonsense_Mutation_p.Y364*|ABCC5_ENST00000492216.1_5'UTR	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	364	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TAAATTTAATGTAAGTAAGAA	0.408000													42	64					4.16155e-14	5.18418e-14	1	1	0
GLUL	2752	broad.mit.edu	37	1	182355445	182355445	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:182355445C>A	ENST00000311223.5	-	5	1317	c.421G>T	c.(421-423)Ggg>Tgg	p.G141W	GLUL_ENST00000331872.6_Missense_Mutation_p.G141W|GLUL_ENST00000491322.1_5'UTR|GLUL_ENST00000339526.4_Missense_Mutation_p.G141W|GLUL_ENST00000417584.2_Missense_Mutation_p.G141W	NM_002065.5	NP_002056.2	P15104	GLNA_HUMAN	glutamate-ammonia ligase	141					cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding			endometrium(2)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	16					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	CCATCTGTCCCCATGAGGGTA	0.527000													43	233					2.26627e-22	3.13924e-22	1	1	0
CRB1	23418	broad.mit.edu	37	1	197403841	197403841	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:197403841G>A	ENST00000367397.1	+	5	1849	c.991G>A	c.(991-993)Gca>Aca	p.A331T	CRB1_ENST00000535699.1_Missense_Mutation_p.A926T|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367400.3_Missense_Mutation_p.A950T|CRB1_ENST00000367399.2_Missense_Mutation_p.A838T|CRB1_ENST00000544212.1_Missense_Mutation_p.A431T			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	950	EGF-like 8.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ATTAGGTATTGCAAATGCTGT	0.294000													44	35					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8492937	8492937	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:8492937G>A	ENST00000381196.4	-	24	2935	c.2392C>T	c.(2392-2394)Ctc>Ttc	p.L798F	PTPRD_ENST00000356435.5_Missense_Mutation_p.L798F|PTPRD_ENST00000540109.1_Missense_Mutation_p.L798F|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000360074.4_Missense_Mutation_p.L785F|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000358503.5_Missense_Mutation_p.L776F|PTPRD_ENST00000397611.3_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	798	Fibronectin type-III 5.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GTGACGGTGAGGGAGTAGGAA	0.488000										TSP Lung(15;0.13)			52	41					0	0	1	0	0
DAAM2	23500	broad.mit.edu	37	6	39832218	39832218	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:39832218G>T	ENST00000538976.1	+	4	450	c.268G>T	c.(268-270)Gac>Tac	p.D90Y	DAAM2_ENST00000398904.2_Missense_Mutation_p.D90Y|DAAM2_ENST00000274867.4_Missense_Mutation_p.D90Y|DAAM2_ENST00000494405.1_3'UTR	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	90	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					GGAGCAGGAGGACCCCAACAA	0.582000													6	15					2.0095e-06	2.20591e-06	1	1	0
PRLR	5618	broad.mit.edu	37	5	35065775	35065775	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:35065775A>G	ENST00000382002.5	-	10	1711	c.1285T>C	c.(1285-1287)Tct>Cct	p.S429P	PRLR_ENST00000397391.3_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000310101.5_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.S328P|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000513753.1_Intron|PRLR_ENST00000511486.1_Missense_Mutation_p.S328P|PRLR_ENST00000231423.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	429					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTGTGGTAAGAGGATCTGGGG	0.498000													29	231					0	0	1	0	0
GSG1L	146395	broad.mit.edu	37	16	27818821	27818821	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:27818821C>A	ENST00000380898.2	-	7	1023	c.474G>T	c.(472-474)gaG>gaT	p.E158D	GSG1L_ENST00000569166.1_Missense_Mutation_p.E158D|GSG1L_ENST00000447459.2_Missense_Mutation_p.E295D|GSG1L_ENST00000380897.3_Missense_Mutation_p.E140D|GSG1L_ENST00000395724.3_Missense_Mutation_p.E244D			Q6UXU4	GSG1L_HUMAN	GSG1-like	295						integral to membrane				endometrium(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(4)	17						CAGGGTATCTCTCGTGGCGGC	0.507000													10	24					3.86212e-05	4.13394e-05	1	1	0
SYNRG	11276	broad.mit.edu	37	17	35932028	35932028	+	Silent	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:35932028T>C	ENST00000339208.6	-	9	1100	c.960A>G	c.(958-960)aaA>aaG	p.K320K	SYNRG_ENST00000502449.2_Silent_p.K242K|SYNRG_ENST00000588194.1_5'UTR|SYNRG_ENST00000585472.1_Silent_p.K241K|SYNRG_ENST00000345615.4_Silent_p.K242K|SYNRG_ENST00000346661.4_Silent_p.K320K|SYNRG_ENST00000394378.2_Silent_p.K242K|SYNRG_ENST00000591288.1_Silent_p.K242K	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	320	EH.				endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TGGGATACAGTTTGGCAGTAT	0.403000													44	87					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216219844	216219844	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:216219844A>G	ENST00000366943.2	-	32	6640	c.6254T>C	c.(6253-6255)aTa>aCa	p.I2085T	USH2A_ENST00000307340.3_Missense_Mutation_p.I2085T			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2085	Fibronectin type-III 7.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTACTGAGTTATAATACCATT	0.468000										HNSCC(13;0.011)			59	32					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	172356363	172356363	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:172356363C>A	ENST00000358155.4	+	19	2325	c.2149C>A	c.(2149-2151)Cag>Aag	p.Q717K	DNM3_ENST00000355305.5_Missense_Mutation_p.Q723K|DNM3_ENST00000367731.1_Missense_Mutation_p.Q713K	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	723	GED.				endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TGAGCAGGCTCAGCGCCGGGA	0.507000													22	119					1.9806e-07	2.20738e-07	1	1	0
MRPS9	64965	broad.mit.edu	37	2	105654564	105654564	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:105654564G>A	ENST00000258455.3	+	1	124	c.14G>A	c.(13-15)tGt>tAt	p.C5Y	AC010884.1_ENST00000456519.1_RNA	NM_182640.2	NP_872578.1	P82933	RT09_HUMAN	mitochondrial ribosomal protein S9	5					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18						GCGGCGCCCTGTGTGTCCTAC	0.677000													7	20					0	0	1	0	0
RNF150	57484	broad.mit.edu	37	4	141832311	141832311	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:141832311G>C	ENST00000306799.3	-	6	1712	c.1059C>G	c.(1057-1059)atC>atG	p.I353M	RNF150_ENST00000420921.2_Missense_Mutation_p.I254M|RNF150_ENST00000507500.1_Missense_Mutation_p.I395M|RNF150_ENST00000379512.2_Missense_Mutation_p.I254M|RNF150_ENST00000515673.1_Missense_Mutation_p.I395M	NM_020724.1	NP_065775.1	Q9ULK6	RN150_HUMAN	ring finger protein 150	395						integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					TAGTAGTAAAGATGACGTCTC	0.468000													39	76					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2210791	2210791	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:2210791C>T	ENST00000398665.3	+	14	1324	c.1288C>T	c.(1288-1290)Caa>Taa	p.Q430*		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	430						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding	p.Q430*(1)		NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAGAAGAACCAAACTGCACT	0.657000													32	84					0	0	1	0	0
ANGEL2	90806	broad.mit.edu	37	1	213181682	213181682	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:213181682G>A	ENST00000366962.3	-	3	666	c.512C>T	c.(511-513)tCc>tTc	p.S171F	ANGEL2_ENST00000544555.1_Missense_Mutation_p.S2F|ANGEL2_ENST00000360506.2_Missense_Mutation_p.S2F|ANGEL2_ENST00000535388.1_Missense_Mutation_p.S2F|ANGEL2_ENST00000540642.1_Missense_Mutation_p.S45F	NM_144567.3	NP_653168.2	Q5VTE6	ANGE2_HUMAN	angel homolog 2 (Drosophila)	171										central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(1)	24				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		TATATTATAGGACATCACTGA	0.363000													16	98					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91835659	91835659	+	Silent	SNP	C	C	A	rs144869683		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:91835659C>A	ENST00000394232.1	+	13	2399	c.1929C>A	c.(1927-1929)acC>acA	p.T643T	SV2B_ENST00000545111.2_Silent_p.T492T|SV2B_ENST00000330276.4_Silent_p.T643T	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	643					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TGGGAAACACCATCTTTGCTT	0.483000													22	57					3.8784e-16	5.01104e-16	1	1	0
POTEF	728378	broad.mit.edu	37	2	130877898	130877898	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:130877898C>A	ENST00000357462.5	-	1	284	c.191G>T	c.(190-192)tGg>tTg	p.W64L	POTEF_ENST00000409914.2_Missense_Mutation_p.W64L|POTEF_ENST00000360967.5_Missense_Mutation_p.W64L|POTEF_ENST00000361163.4_Missense_Mutation_p.W64L			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	64						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						GTGGCGGCACCACTTGCCCAT	0.597000													165	264					1.31598e-77	1.98895e-77	1	1	0
CPNE5	57699	broad.mit.edu	37	6	36742828	36742828	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:36742828T>A	ENST00000244751.2	-	10	1271	c.647A>T	c.(646-648)cAc>cTc	p.H216L		NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	216	C2 2.									central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						CTCGGTCTTGTGGCAAATGGT	0.537000													10	29					0	0	1	0	0
AQP9	366	broad.mit.edu	37	15	58430816	58430816	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:58430816T>A	ENST00000219919.4	+	1	422	c.52T>A	c.(52-54)Ttg>Atg	p.L18M	ALDH1A2_ENST00000558231.1_Intron|AQP9_ENST00000536493.1_Missense_Mutation_p.L18M|AQP9_ENST00000559443.1_3'UTR|AQP9_ENST00000558772.1_Intron	NM_020980.3	NP_066190.2	O43315	AQP9_HUMAN	aquaporin 9	18					cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)	21				GBM - Glioblastoma multiforme(80;0.16)		GAGACTGGTCTTGAAGAGCAG	0.458000													23	38					0	0	1	0	0
CPA5	93979	broad.mit.edu	37	7	130008366	130008366	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:130008366C>A	ENST00000431780.2	+	11	1599	c.1154C>A	c.(1153-1155)tCa>tAa	p.S385*	CPA5_ENST00000485477.1_Silent_p.I413I|CPA5_ENST00000466363.2_Silent_p.I413I|CPA5_ENST00000474905.1_Silent_p.I413I|CPA5_ENST00000355388.3_Silent_p.I413I|CPA5_ENST00000461828.1_Silent_p.I413I|CPA5_ENST00000393213.3_Silent_p.I413I	NM_001127442.1	NP_001120914.1	Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5	0					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(2)|breast(2)|endometrium(2)|large_intestine(7)|lung(4)|ovary(3)|pancreas(1)|skin(2)	23	Melanoma(18;0.0435)					CCACACAGATCATCCCCACGG	0.607000													44	135					1.57945e-13	1.94435e-13	1	1	0
ZNF257	113835	broad.mit.edu	37	19	22255703	22255703	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:22255703G>T	ENST00000594947.1	+	2	240	c.96G>T	c.(94-96)gtG>gtT	p.V32V	ZNF257_ENST00000600162.1_Silent_p.V32V	NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATAGGGATGTGATGTTAGAGA	0.388000													72	126					6.09464e-36	9.02451e-36	1	1	0
KRTAP10-5	386680	broad.mit.edu	37	21	46000028	46000028	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr21:46000028G>T	ENST00000400372.1	-	1	453	c.428C>A	c.(427-429)cCc>cAc	p.P143H	TSPEAR_ENST00000323084.4_Intron	NM_198694.2	NP_941967.2	P60370	KR105_HUMAN	keratin associated protein 10-5	143	22 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(2)|kidney(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	14						AGAACAGGTGGGCACACAGCA	0.612000													111	230					4.98428e-49	7.44075e-49	1	1	0
ASTN2	23245	broad.mit.edu	37	9	119903718	119903718	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:119903718A>G	ENST00000313400.4	-	4	1155	c.1055T>C	c.(1054-1056)aTg>aCg	p.M352T	ASTN2_ENST00000361477.3_Intron|ASTN2_ENST00000373996.3_Missense_Mutation_p.M352T|ASTN2_ENST00000361209.2_Intron			O75129	ASTN2_HUMAN	astrotactin 2	352						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GAACTTCTGCATCAGGGACTC	0.592000													23	17					0	0	1	0	0
PRKCA	5578	broad.mit.edu	37	17	64637527	64637527	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:64637527T>G	ENST00000413366.3	+	4	369	c.343T>G	c.(343-345)Tgc>Ggc	p.C115G		NM_002737.2	NP_002728.1	P17252	KPCA_HUMAN	protein kinase C, alpha	115					activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	CCCCACCTTCTGCGATCACTG	0.473000													90	113					0	0	1	0	0
CPA4	51200	broad.mit.edu	37	7	129950685	129950685	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:129950685G>T	ENST00000222482.4	+	9	880	c.852G>T	c.(850-852)tcG>tcT	p.S284S	CPA4_ENST00000445470.2_Silent_p.S251S|CPA4_ENST00000493259.1_Silent_p.S180S	NM_016352.3	NP_057436.2	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4	284					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Melanoma(18;0.0435)					ACGCCAATTCGGAAGTGGAGG	0.493000													31	100					7.68411e-24	1.0705e-23	1	1	0
CPO	130749	broad.mit.edu	37	2	207833012	207833012	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:207833012A>G	ENST00000272852.3	+	8	849	c.803A>G	c.(802-804)aAt>aGt	p.N268S		NM_173077.2	NP_775100.1	Q8IVL8	CBPO_HUMAN	carboxypeptidase O	268					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	14				LUSC - Lung squamous cell carcinoma(261;0.0744)|Epithelial(149;0.0807)|Lung(261;0.142)		AAGGCAGCAAATGCATTGAAA	0.363000													16	33					0	0	1	0	0
CMTM7	112616	broad.mit.edu	37	3	32483410	32483410	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:32483410G>C	ENST00000334983.5	+	2	474	c.238G>C	c.(238-240)Gtc>Ctc	p.V80L	CMTM7_ENST00000349718.4_Missense_Mutation_p.V80L	NM_138410.2	NP_612419.1	Q96FZ5	CKLF7_HUMAN	CKLF-like MARVEL transmembrane domain containing 7	80	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|large_intestine(1)|lung(2)	4						CTTTGAAGTGGTCACCATTTG	0.532000													71	45					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152644659	152644659	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:152644659G>C	ENST00000367255.5	-	82	16472	c.15871C>G	c.(15871-15873)Cct>Gct	p.P5291A	SYNE1_ENST00000448038.1_Missense_Mutation_p.P5220A|SYNE1_ENST00000341594.5_Missense_Mutation_p.P4984A|SYNE1_ENST00000265368.4_Missense_Mutation_p.P5291A|SYNE1_ENST00000423061.1_Missense_Mutation_p.P5220A	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5291					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATGAGCGGAGGCTCTTCCCCA	0.557000										HNSCC(10;0.0054)			24	74					0	0	1	0	0
KRT13	3860	broad.mit.edu	37	17	39659680	39659680	+	Silent	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:39659680C>G	ENST00000246635.3	-	3	640	c.594G>C	c.(592-594)ctG>ctC	p.L198L	KRT13_ENST00000587544.1_Silent_p.L198L|KRT13_ENST00000336861.3_Silent_p.L198L	NM_153490.2	NP_705694.2	P13646	K1C13_HUMAN	keratin 13	198	Coil 1B.|Rod.				epidermis development	intermediate filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	33		Breast(137;0.000286)				GGCGCAGGGCCAGCTCATTCT	0.493000													36	56					0	0	1	0	0
ENO2	2026	broad.mit.edu	37	12	7031310	7031310	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:7031310G>C	ENST00000535366.1	+	9	1785	c.1159G>C	c.(1159-1161)Ggg>Cgg	p.G387R	ENO2_ENST00000544774.1_Missense_Mutation_p.G344R|ENO2_ENST00000545045.2_Missense_Mutation_p.G268R|ENO2_ENST00000538763.1_Missense_Mutation_p.G344R|ENO2_ENST00000229277.1_Missense_Mutation_p.G387R|ENO2_ENST00000534977.1_Intron|ENO2_ENST00000541477.1_Missense_Mutation_p.G387R			P09104	ENOG_HUMAN	enolase 2 (gamma, neuronal)	387					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex|plasma membrane	magnesium ion binding|phosphopyruvate hydratase activity			endometrium(3)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						CCTGGTGGTGGGGCTGTGCAC	0.572000													19	77					0	0	1	0	0
ACTA2	59	broad.mit.edu	37	10	90703570	90703570	+	Missense_Mutation	SNP	C	C	T	rs112602953		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:90703570C>T	ENST00000458208.1	-	4	827	c.353G>A	c.(352-354)cGg>cAg	p.R118Q	STAMBPL1_ENST00000371927.3_Intron|ACTA2_ENST00000224784.6_Missense_Mutation_p.R118Q|ACTA2_ENST00000480297.1_5'UTR	NM_001141945.1	NP_001135417.1	P62736	ACTA_HUMAN	actin, alpha 2, smooth muscle, aorta	118			R -> Q (in AAT6).		response to virus	cytosol	ATP binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(1)|urinary_tract(2)	17		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		CATTTTCTCCCGGTTGGCCTT	0.537000													30	28					0	0	1	0	0
CCDC140	151278	broad.mit.edu	37	2	223168728	223168728	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:223168728G>T	ENST00000295226.1	+	2	491	c.107G>T	c.(106-108)cGc>cTc	p.R36L		NM_153038.1	NP_694583.1	Q96MF4	CC140_HUMAN	coiled-coil domain containing 140	36								p.R36H(1)		endometrium(4)|large_intestine(1)|prostate(1)	6		Renal(207;0.0376)		Epithelial(121;4.03e-10)|all cancers(144;1.8e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCAACACCCGCGTTCCTCGA	0.567000													19	19					3.57192e-18	4.74092e-18	1	1	0
POU2F3	25833	broad.mit.edu	37	11	120180296	120180296	+	Splice_Site	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:120180296G>T	ENST00000260264.4	+	10	1108		c.e10+1		POU2F3_ENST00000543440.2_Splice_Site	NM_001244682.1	NP_001231611.1	Q9UKI9	PO2F3_HUMAN	POU class 2 homeobox 3						negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)	17		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		CTCCCGGCTGGTGAGTGGCCA	0.577000													23	32					7.92952e-12	9.55206e-12	1	1	0
LPPR5	163404	broad.mit.edu	37	1	99418770	99418770	+	Silent	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:99418770A>G	ENST00000370188.3	-	3	837	c.477T>C	c.(475-477)taT>taC	p.Y159Y	LPPR5_ENST00000263177.4_Silent_p.Y159Y	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		159						integral to membrane	hydrolase activity										CAAGTGCTGTATAATTGGGCT	0.448000													23	44					0	0	1	0	0
LNPEP	4012	broad.mit.edu	37	5	96339245	96339245	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:96339245A>T	ENST00000231368.5	+	9	2472	c.1780A>T	c.(1780-1782)Aat>Tat	p.N594Y	LNPEP_ENST00000395770.3_Missense_Mutation_p.N580Y	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	594			N -> I (in dbSNP:rs12520455).		cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		GGATAGTTTTAATGAGGTAAG	0.353000													29	24					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85992184	85992184	+	Silent	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:85992184A>G	ENST00000372105.3	-	4	1392	c.1371T>C	c.(1369-1371)acT>acC	p.T457T		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	457	Fibronectin type-III.					integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						CACTGAAGGCAGTTGTGTTCT	0.592000													13	10					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66925212	66925212	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:66925212G>T	ENST00000269080.2	-	8	1240	c.1103C>A	c.(1102-1104)gCc>gAc	p.A368D	ABCA8_ENST00000430352.2_Missense_Mutation_p.A368D|ABCA8_ENST00000586539.1_Missense_Mutation_p.A368D	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	368						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					AAGCATGAAGGCAAAGGGACT	0.463000													21	41					3.62473e-10	4.22018e-10	1	1	0
UTRN	7402	broad.mit.edu	37	6	144837953	144837953	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:144837953G>T	ENST00000367545.3	+	38	5410	c.5410G>T	c.(5410-5412)Gag>Tag	p.E1804*		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1804					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TTAGATGGATGAGGAGAGTGC	0.328000													5	9					0.000602214	0.000632542	1	1	0
ZNF620	253639	broad.mit.edu	37	3	40557746	40557746	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:40557746G>A	ENST00000314529.6	+	5	810	c.661G>A	c.(661-663)Gaa>Aaa	p.E221K	ZNF620_ENST00000418905.1_Missense_Mutation_p.E107K	NM_175888.3	NP_787084.1	Q6ZNG0	ZN620_HUMAN	zinc finger protein 620	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(1)|urinary_tract(1)	11				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		TCACACTGGTGAAAAGTCTTT	0.358000													48	23					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57756760	57756760	+	Silent	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:57756760T>G	ENST00000269122.3	+	18	3073	c.2799T>G	c.(2797-2799)gtT>gtG	p.V933V	CLTC_ENST00000393043.1_Silent_p.V933V|CLTC_ENST00000579456.1_Intron	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	933	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TTCTTTAGGTTTGCAATGAGA	0.363000			T	"""ALK, TFE3"""	"""ALCL, renal """								19	31					0	0	1	0	0
MAPT	4137	broad.mit.edu	37	17	44049301	44049301	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:44049301A>T	ENST00000347967.5	+	3	532	c.17A>T	c.(16-18)cAa>cTa	p.Q6L	MAPT_ENST00000571987.1_Silent_p.P70P|MAPT_ENST00000334239.8_Intron|MAPT_ENST00000351559.5_Silent_p.P70P|MAPT_ENST00000574436.1_Silent_p.P70P|MAPT_ENST00000262410.5_Silent_p.P70P|MAPT_ENST00000340799.5_Silent_p.P70P|MAPT_ENST00000535772.1_Silent_p.P70P|MAPT_ENST00000420682.2_Silent_p.P70P|MAPT_ENST00000431008.3_Silent_p.P70P|MAPT_ENST00000415613.2_Silent_p.P70P|MAPT_ENST00000344290.5_Silent_p.P70P|MAPT_ENST00000446361.3_Intron|MAPT_ENST00000570299.1_Intron			P10636	TAU_HUMAN	microtubule-associated protein tau	35					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				AGAGCACTCCAACAGCGGAAG	0.617000													15	44					0	0	1	0	0
C2orf76	130355	broad.mit.edu	37	2	120097421	120097421	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:120097421T>C	ENST00000409466.2	-	3	636	c.115A>G	c.(115-117)Atc>Gtc	p.I39V	C2orf76_ENST00000334816.7_Missense_Mutation_p.I39V|C2orf76_ENST00000409523.1_Missense_Mutation_p.I39V|C2orf76_ENST00000498049.1_5'UTR|C2orf76_ENST00000409877.1_Missense_Mutation_p.I39V			Q3KRA6	CB076_HUMAN	chromosome 2 open reading frame 76	39										large_intestine(1)|lung(3)|pancreas(1)	5						AGAAATACGATAAATTCCTTT	0.338000													20	42					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18023725	18023725	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:18023725G>T	ENST00000205890.5	+	2	1949	c.1611G>T	c.(1609-1611)ccG>ccT	p.P537P		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	537	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TCCTCACGCCGCGCCAGCGCA	0.721000													22	21					1.64113e-05	1.76961e-05	1	1	0
ITPR1	3708	broad.mit.edu	37	3	4774803	4774803	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:4774803G>A	ENST00000354582.6	+	42	5557	c.5207G>A	c.(5206-5208)cGt>cAt	p.R1736H	ITPR1_ENST00000302640.8_Missense_Mutation_p.R1736H|ITPR1_ENST00000456211.2_Missense_Mutation_p.R1688H|ITPR1_ENST00000423119.2_Missense_Mutation_p.R1703H|ITPR1_ENST00000357086.4_Missense_Mutation_p.R1703H|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000443694.2_Missense_Mutation_p.R1736H			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	1751					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CTGGTCAACCGTTACTATGGA	0.507000													19	11					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32632985	32632985	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:32632985G>T	ENST00000242310.4	-	1	2682	c.2593C>A	c.(2593-2595)Cta>Ata	p.L865I		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	865					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CAGAGCTTTAGCCTCTTCCGG	0.463000													60	120					2.73361e-28	3.87483e-28	1	1	0
FAAH2	158584	broad.mit.edu	37	X	57337061	57337061	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:57337061A>T	ENST00000374900.4	+	3	431	c.311A>T	c.(310-312)gAt>gTt	p.D104V		NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	104						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						CATGCTGTAGATCAAAAGCTT	0.408000										HNSCC(52;0.14)			18	10					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75114977	75114977	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:75114977G>T	ENST00000326665.5	-	2	264	c.46C>A	c.(46-48)Ctt>Att	p.L16I		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	16										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTATCCATAAGGCTATTATAT	0.363000													14	49					6.31663e-08	7.10499e-08	1	1	0
PDZD2	23037	broad.mit.edu	37	5	32088117	32088117	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:32088117C>A	ENST00000438447.1	+	20	4951	c.4563C>A	c.(4561-4563)agC>agA	p.S1521R	PDZD2_ENST00000282493.3_Missense_Mutation_p.S1521R			O15018	PDZD2_HUMAN	PDZ domain containing 2	1521					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						ACTTTCTGAGCAACTACTCTA	0.488000													37	19					2.87052e-16	3.72861e-16	1	1	0
IGKV3D-20	28874	broad.mit.edu	37	2	90078085	90078085	+	RNA	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:90078085T>A	ENST00000390270.2	+	0	219																											AGAGCCACCCTCTCCTGCGGG	0.537000													6	230					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138964104	138964104	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:138964104A>T	ENST00000288561.8	+	13	2065	c.1816A>T	c.(1816-1818)Aag>Tag	p.K606*	UBN2_ENST00000473989.2_Nonsense_Mutation_p.K689*	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2	689										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						ACCCAAAGTAAAGGTAAGTAC	0.308000													7	35					0	0	1	0	0
ZNF836	162962	broad.mit.edu	37	19	52660719	52660719	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:52660719C>A	ENST00000322146.8	-	5	738	c.217G>T	c.(217-219)Gtg>Ttg	p.V73L	ZNF836_ENST00000597252.1_Missense_Mutation_p.V73L|CTC-471J1.8_ENST00000594362.1_RNA	NM_001102657.1	NP_001096127.1	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	73	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						TCCAGCGTCACTGTTTGGCAT	0.358000													11	18					1.58986e-06	1.74789e-06	1	1	0
NHS	4810	broad.mit.edu	37	X	17743958	17743958	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:17743958G>T	ENST00000380060.3	+	6	2007	c.1669G>T	c.(1669-1671)Gag>Tag	p.E557*	NHS_ENST00000398097.3_Nonsense_Mutation_p.E401*	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	557						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					CAAATTAAGTGAGAGGGGAAG	0.577000													44	20					4.67007e-22	6.43235e-22	1	1	0
TRAV8-7	28679	broad.mit.edu	37	14	22600966	22600966	+	RNA	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:22600966C>T	ENST00000390456.3	+	0	311																											AGTGATGCTGCTGAGTACTTC	0.502000													24	22					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2216475	2216475	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:2216475A>G	ENST00000398665.3	+	20	2155	c.2119A>G	c.(2119-2121)Atg>Gtg	p.M707V		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	707						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTGAGCAGCATGAGCCCGGA	0.672000													38	79					0	0	1	0	0
VAV2	7410	broad.mit.edu	37	9	136726538	136726538	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:136726538G>C	ENST00000371851.1	-	3	663	c.338C>G	c.(337-339)tCg>tGg	p.S113W	VAV2_ENST00000406606.3_Missense_Mutation_p.S113W|VAV2_ENST00000371850.3_Missense_Mutation_p.S113W|VAV2_ENST00000486113.1_5'UTR			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	113	CH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		GGAGAGCCTCGACACCGCGGA	0.577000													4	12					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454456	84454456	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr13:84454456A>T	ENST00000377084.2	-	1	2072	c.1187T>A	c.(1186-1188)gTg>gAg	p.V396E		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	396						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CTTGTAATCCACAAAGTGCGA	0.453000													82	199					0	0	1	0	0
CABP4	57010	broad.mit.edu	37	11	67223911	67223911	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:67223911G>C	ENST00000438189.2	+	4	568	c.224G>C	c.(223-225)cGc>cCc	p.R75P	CABP4_ENST00000325656.5_Missense_Mutation_p.R180P			P57796	CABP4_HUMAN	calcium binding protein 4	180					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding			central_nervous_system(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(2)	11			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			ATCAAGATGCGCAGTCAGTCA	0.672000													20	38					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237789017	237789017	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:237789017G>T	ENST00000366574.2	+	40	6396	c.6079G>T	c.(6079-6081)Ggg>Tgg	p.G2027W	RYR2_ENST00000542537.1_Missense_Mutation_p.G2011W|RYR2_ENST00000360064.6_Missense_Mutation_p.G2025W	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2027	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AACAATTAGAGGGCGTCTGCT	0.383000													13	84					0.00136819	0.0014248	1	1	0
SLC6A19	340024	broad.mit.edu	37	5	1210639	1210639	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:1210639A>T	ENST00000304460.10	+	3	480	c.424A>T	c.(424-426)Aac>Tac	p.N142Y		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	142					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GTACTTATTCAACTCCTTCCA	0.577000													14	67					0	0	1	0	0
PCDHB17P	54661	broad.mit.edu	37	5	140536803	140536803	+	Silent	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:140536803G>C	ENST00000539533.1	+	1	1227	c.1227G>C	c.(1225-1227)gcG>gcC	p.A409A																								CAGAAGGAGCGCTAGACAGAG	0.468000													41	17					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117389278	117389278	+	Missense_Mutation	SNP	G	G	T	rs146015983		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:117389278G>T	ENST00000321322.6	-	7	1594	c.1593C>A	c.(1591-1593)aaC>aaA	p.N531K	DSCAML1_ENST00000527706.1_Missense_Mutation_p.N261K	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	471	Ig-like C2-type 6.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GGCCTGTGACGTTCATGTGGC	0.632000													30	66					4.15321e-07	4.62171e-07	1	1	0
ANO2	57101	broad.mit.edu	37	12	6031869	6031869	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:6031869C>A	ENST00000327087.8	-	2	183	c.112G>T	c.(112-114)Ggt>Tgt	p.G38C	ANO2_ENST00000356134.5_Missense_Mutation_p.G38C|ANO2_ENST00000546188.1_Missense_Mutation_p.G38C			Q9NQ90	ANO2_HUMAN	anoctamin 2	42						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GCCCGGGGACCTGGCATCTTG	0.682000													3	10					0.00909568	0.00923484	1	1	0
TGIF1	7050	broad.mit.edu	37	18	3456507	3456507	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:3456507C>G	ENST00000472042.1	+	1	1096	c.112C>G	c.(112-114)Cgt>Ggt	p.R38G	TGIF1_ENST00000407501.2_Missense_Mutation_p.R58G|TGIF1_ENST00000345133.5_Missense_Mutation_p.R38G|TGIF1_ENST00000343820.5_Missense_Mutation_p.R58G|TGIF1_ENST00000577543.1_Missense_Mutation_p.R58G|TGIF1_ENST00000551541.1_Missense_Mutation_p.R38G|TGIF1_ENST00000551402.1_Missense_Mutation_p.R58G|TGIF1_ENST00000330513.5_Missense_Mutation_p.R187G|TGIF1_ENST00000548489.2_Missense_Mutation_p.R72G|TGIF1_ENST00000400167.2_Missense_Mutation_p.R38G|TGIF1_ENST00000405385.3_Missense_Mutation_p.R38G|TGIF1_ENST00000401449.1_Missense_Mutation_p.R38G			Q15583	TGIF1_HUMAN	TGFB-induced factor homeobox 1	187					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13	Esophageal squamous(4;0.0859)	Colorectal(8;0.0104)				GTATGAGCACCGTTACAATGC	0.502000													93	1519					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37006527	37006527	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:37006527G>A	ENST00000282516.8	+	17	4423	c.3924G>A	c.(3922-3924)gcG>gcA	p.A1308A	NIPBL_ENST00000448238.2_Silent_p.A1308A	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	1308					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding	p.A1308A(2)		autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CAAAATCAGCGGATGCTTGTC	0.338000													76	41					0	0	1	0	0
KIAA1161	57462	broad.mit.edu	37	9	34371054	34371054	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:34371054C>G	ENST00000297625.7	-	2	2011	c.1786G>C	c.(1786-1788)Ggt>Cgt	p.G596R		NM_020702.3	NP_065753.2	Q6NSJ0	K1161_HUMAN	KIAA1161	630					carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		ATAGGGTCACCCGTGTCGGTG	0.662000													18	32					0	0	1	0	0
MARCH6	10299	broad.mit.edu	37	5	10423871	10423871	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:10423871G>T	ENST00000274140.5	+	23	2440	c.2308G>T	c.(2308-2310)Gcc>Tcc	p.A770S	MARCH6_ENST00000503788.1_Missense_Mutation_p.A665S|MARCH6_ENST00000449913.2_Missense_Mutation_p.A722S|MARCH6_ENST00000510792.1_Missense_Mutation_p.A468S	NM_005885.2	NP_005876.2	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	770					protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(35)|ovary(1)|urinary_tract(3)	54						AGTCCTGCATGCCAAAATCAT	0.368000													14	83					2.23348e-06	2.44811e-06	1	1	0
SPN	6693	broad.mit.edu	37	16	29675878	29675878	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:29675878T>C	ENST00000360121.3	+	2	921	c.829T>C	c.(829-831)Tgg>Cgg	p.W277R	SPN_ENST00000395389.2_Missense_Mutation_p.W277R|AC009133.19_ENST00000449759.1_Intron	NM_001030288.2|NM_003123.4	NP_001025459.1|NP_003114.1	P16150	LEUK_HUMAN	sialophorin	277					blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|stomach(1)	15						GCTCCTGCTGTGGCGCCGGCG	0.692000													10	26					0	0	1	0	0
FGF13	2258	broad.mit.edu	37	X	137717804	137717804	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:137717804G>T	ENST00000315930.6	-	4	1076	c.415C>A	c.(415-417)Cct>Act	p.P139T	FGF13_ENST00000541469.1_Missense_Mutation_p.P93T|FGF13_ENST00000441825.2_Missense_Mutation_p.P120T|FGF13_ENST00000305414.4_Missense_Mutation_p.P86T|FGF13_ENST00000370603.3_Missense_Mutation_p.P149T	NM_004114.3	NP_004105.1	Q92913	FGF13_HUMAN	fibroblast growth factor 13	139					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	24	Acute lymphoblastic leukemia(192;0.000127)					TTGCACTCAGGTGTGAAAAGT	0.363000													21	14					0.000175454	0.000185089	1	1	0
ASXL3	80816	broad.mit.edu	37	18	31322991	31322991	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:31322991G>C	ENST00000269197.5	+	12	3179	c.3179G>C	c.(3178-3180)cGg>cCg	p.R1060P		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1060	Ala-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ATCAAGGCCCGGGCCCAACAA	0.617000													20	13					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141986941	141986941	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:141986941C>A	ENST00000389484.3	-	6	1632	c.661G>T	c.(661-663)Gga>Tga	p.G221*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	221					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTTTACTTCCATTAAGATAG	0.289000										TSP Lung(27;0.18)			20	35					3.99206e-14	4.98154e-14	1	1	0
HLA-V	352962	broad.mit.edu	37	6	29761635	29761635	+	RNA	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:29761635G>A	ENST00000457107.1	+	0	861																											cctgttgtaagtgtgagcaga	0.498000													3	17					0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33110209	33110209	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:33110209G>A	ENST00000306065.4	-	20	2122	c.1964C>T	c.(1963-1965)tCa>tTa	p.S655L		NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	655					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					TGAGCTGGCTGACATGGAGGA	0.647000													29	114					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137150721	137150721	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:137150721T>C	ENST00000453654.1	-	27	2238	c.1699A>G	c.(1699-1701)Atg>Gtg	p.M567V	DGKI_ENST00000446122.1_Missense_Mutation_p.M839V|DGKI_ENST00000424189.2_Missense_Mutation_p.M870V|DGKI_ENST00000288490.5_Missense_Mutation_p.M857V			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	857					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						GACACCACCATATCTGGGTCC	0.512000													18	74					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58714638	58714638	+	Splice_Site	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:58714638G>C	ENST00000317391.4	+	4	418	c.78_splice	c.e4+1	p.K26_splice	GLYATL1_ENST00000300079.5_Intron|RP11-142C4.6_ENST00000533954.1_RNA	NM_001220494.1	NP_001207423.1	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	26						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	AGTCCCTGAAGGTCAGGGAAC	0.512000													17	31					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55135409	55135409	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:55135409G>A	ENST00000314706.3	+	1	50	c.50G>A	c.(49-51)tGt>tAt	p.C17Y		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	17					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						CCTTTTGTTTGTAGGCTCCGA	0.433000													18	35					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7645622	7645622	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:7645622G>T	ENST00000340209.4	+	5	852	c.555G>T	c.(553-555)gtG>gtT	p.V185V	RBFOX1_ENST00000552089.1_Silent_p.V197V|RBFOX1_ENST00000311745.5_Silent_p.V200V|RBFOX1_ENST00000550418.1_Silent_p.V180V|RBFOX1_ENST00000422070.4_Silent_p.V223V|RBFOX1_ENST00000547338.1_Silent_p.V180V|RBFOX1_ENST00000436368.2_Silent_p.V200V|RBFOX1_ENST00000535565.2_Intron|RBFOX1_ENST00000355637.4_Silent_p.V200V|RBFOX1_ENST00000553186.1_Silent_p.V180V|RBFOX1_ENST00000547372.1_Silent_p.V223V			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	180	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						ACGGCACCGTGGTAGAGGGCC	0.448000													43	108					5.7616e-29	8.23086e-29	1	1	0
COL24A1	255631	broad.mit.edu	37	1	86590878	86590878	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:86590878C>A	ENST00000370571.2	-	3	1507	c.1141G>T	c.(1141-1143)Gat>Tat	p.D381Y	COL24A1_ENST00000436319.1_Missense_Mutation_p.D381Y	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	381					cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		ACTCTATCATCATGTTGTGTG	0.383000													29	46					7.26314e-15	9.18907e-15	1	1	0
COL4A4	1286	broad.mit.edu	37	2	227922252	227922252	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:227922252C>T	ENST00000396625.3	-	29	2655	c.2448G>A	c.(2446-2448)ggG>ggA	p.G816G	COL4A4_ENST00000329662.7_Silent_p.G816G	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	816	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CACCTGGAAACCCAGCATGTC	0.547000													11	16					0	0	1	0	0
SLC35F1	222553	broad.mit.edu	37	6	118596744	118596744	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:118596744G>T	ENST00000360388.4	+	5	961	c.760G>T	c.(760-762)Ggt>Tgt	p.G254C		NM_001029858.3	NP_001025029.2	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	254					transport	integral to membrane				breast(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(226;0.217)		GGGAATGATTGGTCTCTTTGG	0.393000													38	54					9.85521e-28	1.39424e-27	1	1	0
OR2W1	26692	broad.mit.edu	37	6	29012785	29012785	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:29012785A>T	ENST00000377175.1	-	1	232	c.168T>A	c.(166-168)caT>caA	p.H56Q		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	56					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						ACATTGGTGTATGAAGCTGGG	0.433000													43	64					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82817080	82817080	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:82817080G>A	ENST00000265077.3	+	7	3520	c.2955G>A	c.(2953-2955)gtG>gtA	p.V985V	VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Silent_p.V937V|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000342785.4_Silent_p.V985V	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	985	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACTGGGGAGTGTTAGTACCTT	0.428000													4	70					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802584	185802584	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:185802584C>A	ENST00000302277.6	+	4	3055	c.2461C>A	c.(2461-2463)Ccc>Acc	p.P821T		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	821						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						CAGATTCCACCCCGGATTTGA	0.388000													21	43					8.10497e-08	9.08853e-08	1	1	0
PGBD2	267002	broad.mit.edu	37	1	249211348	249211348	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:249211348A>C	ENST00000539153.1	+	4	811	c.556A>C	c.(556-558)Agt>Cgt	p.S186R	PGBD2_ENST00000462488.1_Intron|PGBD2_ENST00000329291.5_Missense_Mutation_p.S189R|PGBD2_ENST00000355360.4_Intron			Q6P3X8	PGBD2_HUMAN	piggyBac transposable element derived 2	189										NS(1)|endometrium(3)|lung(6)|ovary(1)|skin(3)	14	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TTTGATTTTAAGTGGGTACAT	0.393000													39	215					0	0	1	0	0
MSH2	4436	broad.mit.edu	37	2	47707857	47707857	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:47707857G>A	ENST00000406134.1	+	15	2543	c.2481G>A	c.(2479-2481)ggG>ggA	p.G827G	MSH2_ENST00000543555.1_Silent_p.G761G|MSH2_ENST00000233146.2_Silent_p.G827G			P43246	MSH2_HUMAN	mutS homolog 2	827					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.0?(2)|p.?(2)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(5)|large_intestine(50)|lung(18)|ovary(5)|prostate(2)|skin(3)|small_intestine(1)|stomach(2)|urinary_tract(1)	112		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AAAGTTTTGGGATTCATGTTG	0.408000			"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian"""	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				3	26					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146755727	146755727	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:146755727A>T	ENST00000361719.2	+	9	3850	c.3380A>T	c.(3379-3381)gAg>gTg	p.E1127V	GRM1_ENST00000492807.2_3'UTR|GRM1_ENST00000507907.1_3'UTR|GRM1_ENST00000392299.2_3'UTR|GRM1_ENST00000282753.1_Missense_Mutation_p.E1127V|GRM1_ENST00000355289.4_3'UTR	NM_001278064.1	NP_001264993.1	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	1127	Asp/Glu-rich (acidic).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CTGGAAGAGGAGGAGGAGGAC	0.637000													64	96					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27349396	27349396	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:27349396C>G	ENST00000429845.2	-	12	1119	c.757G>C	c.(757-759)Gaa>Caa	p.E253Q	NEK10_ENST00000341435.5_Missense_Mutation_p.E253Q			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	253							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						AACAGATTTTCTACAATGTTG	0.303000													17	11					0	0	1	0	0
APCDD1	147495	broad.mit.edu	37	18	10471671	10471671	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:10471671C>A	ENST00000355285.4	+	3	741	c.387C>A	c.(385-387)cgC>cgA	p.R129R	APCDD1_ENST00000578882.1_Silent_p.R129R	NM_153000.4	NP_694545.1	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	129					hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				READ - Rectum adenocarcinoma(15;0.08)		GCAAGATCCGCCTCCGCCAGG	0.562000													43	72					6.4771e-29	9.23493e-29	1	1	0
PCDHGA7	56108	broad.mit.edu	37	5	140764612	140764612	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:140764612C>T	ENST00000518325.1	+	1	2146	c.2146C>T	c.(2146-2148)Ctg>Ttg	p.L716L	PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGCTCAGGCTGCGGCGCTG	0.622000													45	37					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89390979	89390979	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:89390979C>A	ENST00000336596.2	+	5	1270	c.1045C>A	c.(1045-1047)Ctg>Atg	p.L349M	EPHA3_ENST00000494014.1_Missense_Mutation_p.L349M|EPHA3_ENST00000452448.2_Missense_Mutation_p.L349M	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	349	Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GAGTTGGCCCCTGGACACAGG	0.428000										TSP Lung(6;0.00050)			29	61					1.88708e-17	2.47765e-17	1	1	0
NLGN1	22871	broad.mit.edu	37	3	173998912	173998912	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:173998912T>C	ENST00000457714.1	+	7	2720	c.2291T>C	c.(2290-2292)cTa>cCa	p.L764P	NLGN1_ENST00000401917.3_Missense_Mutation_p.L804P|NLGN1_ENST00000361589.4_Missense_Mutation_p.L764P|NLGN1_ENST00000545397.1_Missense_Mutation_p.L764P	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	781					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GATTACACACTAGCTATGAGG	0.468000													60	99					0	0	1	0	0
HAVCR1	26762	broad.mit.edu	37	5	156485002	156485002	+	Translation_Start_Site	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:156485002C>A	ENST00000339252.3	-	0	485				HAVCR1_ENST00000425854.1_De_novo_Start_OutOfFrame|HAVCR1_ENST00000544197.1_Intron|HAVCR1_ENST00000523175.1_Intron|HAVCR1_ENST00000522693.1_De_novo_Start_OutOfFrame	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1						interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTTGGTACCCTCCACCAGAT	0.453000													12	10					6.40141e-05	6.812e-05	1	1	0
CHERP	10523	broad.mit.edu	37	19	16638948	16638948	+	Silent	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:16638948T>C	ENST00000546361.2	-	9	1399	c.1248A>G	c.(1246-1248)ccA>ccG	p.P416P	CTD-3222D19.2_ENST00000409035.1_Intron|CHERP_ENST00000198939.6_Silent_p.P427P	NM_006387.5	NP_006378.3	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum protein	416	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|stomach(1)|urinary_tract(3)	24						GGGGCTTGTTTGGTGGGATCT	0.647000													32	107					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92620259	92620259	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:92620259C>A	ENST00000298047.6	+	24	13048	c.13031C>A	c.(13030-13032)tCa>tAa	p.S4344*	FAT3_ENST00000525166.1_Nonsense_Mutation_p.S4194*|FAT3_ENST00000489716.1_3'UTR|FAT3_ENST00000533797.1_Nonsense_Mutation_p.S679*|FAT3_ENST00000409404.2_Nonsense_Mutation_p.S4344*			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4344					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCCTTCCAGTCAGATTCTGGT	0.512000										TCGA Ovarian(4;0.039)			6	16					0.00198382	0.00204836	1	1	0
SLC19A3	80704	broad.mit.edu	37	2	228564092	228564092	+	Silent	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:228564092A>G	ENST00000258403.3	-	3	410	c.339T>C	c.(337-339)taT>taC	p.Y113Y	SLC19A3_ENST00000409287.1_Intron|SLC19A3_ENST00000541617.1_Silent_p.Y109Y	NM_025243.3	NP_079519.1	Q9BZV2	S19A3_HUMAN	solute carrier family 19 (thiamine transporter), member 3	113					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|skin(3)	30		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	TGACCATCCCATAGAAGAACT	0.542000													6	180					0	0	1	0	0
AGPAT4	56895	broad.mit.edu	37	6	161587367	161587367	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:161587367C>T	ENST00000320285.4	-	3	473	c.261G>A	c.(259-261)aaG>aaA	p.K87K	AGPAT4_ENST00000366906.5_Silent_p.K25K|AGPAT4_ENST00000366908.5_Silent_p.K87K|AGPAT4_ENST00000366911.5_Intron|AGPAT4_ENST00000457520.2_Intron|AGPAT4_ENST00000366905.3_Silent_p.K87K	NM_020133.2	NP_064518.1	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	87					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding			endometrium(1)|large_intestine(10)|lung(10)|ovary(2)|skin(2)	25		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		TGGCATTTTCCTTCCCATACT	0.532000													34	49					0	0	1	0	0
CPM	1368	broad.mit.edu	37	12	69260746	69260746	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:69260746C>T	ENST00000551568.1	-	7	930	c.870G>A	c.(868-870)gaG>gaA	p.E290E	CPM_ENST00000546373.1_Silent_p.E290E|CPM_ENST00000338356.3_Silent_p.E290E	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	290					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			GAAGCTTCTCCTCACGAGGAT	0.358000													33	52					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088007	9088007	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:9088007C>T	ENST00000397910.4	-	1	4011	c.3808G>A	c.(3808-3810)Gct>Act	p.A1270T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1270	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACTACTGAAGCCATGGTAAGT	0.493000													154	380					0	0	1	0	0
SLC35F2	54733	broad.mit.edu	37	11	107686528	107686528	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:107686528C>T	ENST00000525071.1	-	5	862	c.274G>A	c.(274-276)Gca>Aca	p.A92T	SLC35F2_ENST00000429869.1_Missense_Mutation_p.A92T|SLC35F2_ENST00000375682.4_Missense_Mutation_p.A45T|SLC35F2_ENST00000265836.7_Intron|SLC35F2_ENST00000525815.1_Missense_Mutation_p.A92T			Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	92					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		GATCGAAATGCCAGCATCACT	0.348000													69	111					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166915161	166915161	+	Missense_Mutation	SNP	C	C	T	rs121917918		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:166915161C>T	ENST00000423058.2	-	2	319	c.302G>A	c.(301-303)cGg>cAg	p.R101Q	SCN1A_ENST00000409050.1_Missense_Mutation_p.R101Q|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.R101Q|AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.R101Q	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	101			R -> Q (in SMEI; dbSNP:rs121917918).|R -> W (in SMEI; dbSNP:rs121917965).			voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGCACTGAACCGGAAGATGGC	0.358000													13	36					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43627664	43627664	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:43627664C>A	ENST00000332857.6	-	4	1051	c.1023G>T	c.(1021-1023)tgG>tgT	p.W341C		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		CTTTTTCTTCCCAAATGTTGA	0.428000													134	103					2.27795e-59	3.42866e-59	1	1	0
LRIT3	345193	broad.mit.edu	37	4	110791582	110791582	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:110791582G>A	ENST00000327908.3	+	4	1892	c.1128G>A	c.(1126-1128)gtG>gtA	p.V376V	LRIT3_ENST00000594814.1_Silent_p.V559V|LRIT3_ENST00000409621.2_Silent_p.V376V|LRIT3_ENST00000379920.3_Silent_p.V514V			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	514	Ser-rich.					integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		CAAAAGGAGTGCCTCCCCAGA	0.498000													35	73					0	0	1	0	0
FEZF1	389549	broad.mit.edu	37	7	121942294	121942294	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:121942294G>T	ENST00000442488.2	-	4	1252	c.1185C>A	c.(1183-1185)aaC>aaA	p.N395K	FEZF1_ENST00000331178.4_Missense_Mutation_p.N391K|FEZF1_ENST00000427185.2_Missense_Mutation_p.N345K	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	395					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						GCTTCTTGTCGTTGTGGGTGT	0.547000													21	91					1.64293e-13	2.01909e-13	1	1	0
MNDA	4332	broad.mit.edu	37	1	158817612	158817612	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:158817612G>C	ENST00000368141.4	+	6	1343	c.1082G>C	c.(1081-1083)tGt>tCt	p.C361S		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	361	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					AATATCAAGTGTGAGAAAGGA	0.428000													44	79					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85960372	85960372	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:85960372A>T	ENST00000372117.3	+	6	557	c.454A>T	c.(454-456)Agc>Tgc	p.S152C	CDHR1_ENST00000332904.3_Missense_Mutation_p.S152C	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	152	Cadherin 2.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						ACCTGCTGGGAGCATCATCTT	0.582000													6	9					0	0	1	0	0
REG1A	5967	broad.mit.edu	37	2	79348048	79348048	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:79348048C>A	ENST00000233735.1	+	2	164	c.61C>A	c.(61-63)Caa>Aaa	p.Q21K		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	21					positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						GTCTCAGAGCCAAGGTAAGAT	0.438000													40	17					5.71845e-15	7.24734e-15	1	1	0
RGPD3	653489	broad.mit.edu	37	2	107049681	107049681	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:107049681T>C	ENST00000409886.3	-	16	2353	c.2266A>G	c.(2266-2268)Aac>Gac	p.N756D	RGPD3_ENST00000304514.7_Missense_Mutation_p.N756D	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	756					intracellular transport		binding	p.N756D(6)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TCACTATAGTTTTCGAGTTCC	0.373000													5	327					0	0	1	0	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066427	46066427	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr21:46066427C>A	ENST00000334670.8	+	1	97	c.52C>A	c.(52-54)Cag>Aag	p.Q18K	TSPEAR_ENST00000323084.4_Intron	NM_198692.2	NP_941965.2	P60411	KR109_HUMAN	keratin associated protein 10-11	18						keratin filament				NS(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)	12						CGACTCCTGGCAGGTGGACGA	0.682000													4	138					1.23904e-05	1.34199e-05	1	1	0
CEP350	9857	broad.mit.edu	37	1	180047719	180047719	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:180047719G>T	ENST00000367607.3	+	29	6307	c.5889G>T	c.(5887-5889)caG>caT	p.Q1963H		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1963						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						CTATAGGACAGGAGCAGCCAG	0.423000													9	40					5.4927e-09	6.27492e-09	1	1	0
PRAME	23532	broad.mit.edu	37	22	22892163	22892163	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr22:22892163A>C	ENST00000543184.1	-	4	1800	c.938T>G	c.(937-939)cTg>cGg	p.L313R	PRAME_ENST00000398743.2_Missense_Mutation_p.L313R|PRAME_ENST00000424204.2_Missense_Mutation_p.L297R|PRAME_ENST00000539862.1_Missense_Mutation_p.L297R|PRAME_ENST00000405655.3_Missense_Mutation_p.L313R|PRAME_ENST00000398741.1_Missense_Mutation_p.L313R|PRAME_ENST00000402697.1_Missense_Mutation_p.L313R	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	313					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		CAACTGATCCAGGCGGCCTCT	0.483000													18	18					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	240990451	240990451	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:240990451C>A	ENST00000366565.1	-	10	1012	c.631G>T	c.(631-633)Gaa>Taa	p.E211*	RGS7_ENST00000366563.1_Nonsense_Mutation_p.E211*|RGS7_ENST00000366562.4_Nonsense_Mutation_p.E211*|RGS7_ENST00000446183.2_Nonsense_Mutation_p.E127*|RGS7_ENST00000348120.2_Nonsense_Mutation_p.E158*|RGS7_ENST00000366564.1_Nonsense_Mutation_p.E211*|RGS7_ENST00000331110.7_Nonsense_Mutation_p.E185*|RGS7_ENST00000407727.1_Nonsense_Mutation_p.E211*|RGS7_ENST00000401882.1_Nonsense_Mutation_p.E158*	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	211					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			ATGTCCACTTCAGTTGTATTT	0.418000													17	76					5.3912e-06	5.88278e-06	1	1	0
IKZF2	22807	broad.mit.edu	37	2	213914594	213914594	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:213914594G>A	ENST00000457361.1	-	5	585	c.417C>T	c.(415-417)ccC>ccT	p.P139P	IKZF2_ENST00000342002.2_Silent_p.P145P|IKZF2_ENST00000451136.2_Silent_p.P113P|IKZF2_ENST00000374319.4_Silent_p.P113P|IKZF2_ENST00000374327.4_Intron|IKZF2_ENST00000421754.2_Silent_p.P113P|IKZF2_ENST00000434687.1_Silent_p.P139P|IKZF2_ENST00000413091.3_Silent_p.P139P	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		TACAGTGGAAGGGGCGTTCAC	0.448000													12	22					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170732404	170732404	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:170732404G>A	ENST00000314251.3	-	3	304	c.225C>T	c.(223-225)aaC>aaT	p.N75N	SLC2A2_ENST00000382808.4_Intron	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	75					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			TTGGTTTTGGGTTCATTGAGT	0.463000													113	57					0	0	1	0	0
UGT1A4	54657	broad.mit.edu	37	2	234627556	234627556	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:234627556G>T	ENST00000373409.3	+	1	133	c.90G>T	c.(88-90)aaG>aaT	p.K30N	UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A5_ENST00000373414.3_Intron	NM_007120.2	NP_009051.1														autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	26		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)		AGAGTGGAAAGGTGTTGGTGG	0.667000													18	49					9.16793e-09	1.04409e-08	1	1	0
ACLY	47	broad.mit.edu	37	17	40034450	40034450	+	Splice_Site	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:40034450C>A	ENST00000352035.2	-	22	2524		c.e22-1		ACLY_ENST00000393896.2_Splice_Site|ACLY_ENST00000537919.1_Splice_Site|ACLY_ENST00000590151.1_Splice_Site|ACLY_ENST00000353196.1_Splice_Site	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase						ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				GTATACAGACCTGGGAGGCAG	0.507000													8	25					0.000157383	0.000166266	1	1	0
DYNC2LI1	51626	broad.mit.edu	37	2	44021790	44021790	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:44021790G>A	ENST00000406852.3	+	6	605	c.515G>A	c.(514-516)tGc>tAc	p.C172Y	DYNC2LI1_ENST00000443170.3_Intron|DYNC2LI1_ENST00000605786.1_Intron|DYNC2LI1_ENST00000260605.8_Intron|DYNC2LI1_ENST00000489222.2_Intron|DYNC2LI1_ENST00000398823.2_3'UTR	NM_015522.3	NP_056337.1	Q8TCX1	DC2L1_HUMAN	dynein, cytoplasmic 2, light intermediate chain 1	0						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|skin(1)	26		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CCTGTGAGTTGCTGTTTGGGA	0.338000													33	43					0	0	1	0	0
TMEM176B	28959	broad.mit.edu	37	7	150493555	150493555	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:150493555G>T	ENST00000447204.2	-	2	475	c.103C>A	c.(103-105)Caa>Aaa	p.Q35K	TMEM176B_ENST00000450753.2_Missense_Mutation_p.Q35K|TMEM176B_ENST00000492607.1_Missense_Mutation_p.Q35K|TMEM176B_ENST00000434545.1_Missense_Mutation_p.Q35K|TMEM176B_ENST00000429904.2_Missense_Mutation_p.Q35K|TMEM176B_ENST00000326442.5_Missense_Mutation_p.Q35K	NM_014020.3	NP_054739.3	Q3YBM2	T176B_HUMAN	transmembrane protein 176B	35					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTCAGCAGTTGTGTCAAAGCT	0.532000													13	74					0.000151284	0.00016052	1	1	0
LOC100128164	100128164	broad.mit.edu	37	3	169663677	169663677	+	RNA	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:169663677G>A	ENST00000483289.2	-	0	3617				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						CATTTTACAGGGCAGGAGCCC	0.453000													25	102					0	0	1	0	0
ZNF226	7769	broad.mit.edu	37	19	44679718	44679718	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:44679718G>T	ENST00000590089.1	+	7	670	c.303G>T	c.(301-303)tgG>tgT	p.W101C	ZNF226_ENST00000454662.2_Missense_Mutation_p.W101C|ZNF226_ENST00000588883.1_3'UTR|ZNF226_ENST00000337433.5_Missense_Mutation_p.W101C			Q9NYT6	ZN226_HUMAN	zinc finger protein 226	101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				TTTCTTGTTGGCAAATCTGGC	0.378000													20	20					1.01871e-10	1.21315e-10	1	1	0
LINGO4	339398	broad.mit.edu	37	1	151774476	151774476	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:151774476G>T	ENST00000368820.3	-	2	1642	c.705C>A	c.(703-705)atC>atA	p.I235I		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	235						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCCAGAGGTGGATCTCCAGCT	0.637000													27	81					6.12954e-19	8.2102e-19	1	1	0
GRIN2A	2903	broad.mit.edu	37	16	9943623	9943623	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:9943623C>T	ENST00000396573.2	-	6	1627	c.1318G>A	c.(1318-1320)Gtc>Atc	p.V440I	GRIN2A_ENST00000562109.1_Missense_Mutation_p.V440I|GRIN2A_ENST00000330684.3_Missense_Mutation_p.V440I|GRIN2A_ENST00000404927.2_Missense_Mutation_p.V440I|GRIN2A_ENST00000535259.1_Missense_Mutation_p.V283I|GRIN2A_ENST00000396575.2_Missense_Mutation_p.V440I	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	440					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGATTTTGACGAACTTCCGA	0.507000													43	78					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12655897	12655897	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:12655897C>T	ENST00000425538.1	+	10	1492	c.1292C>T	c.(1291-1293)cCc>cTc	p.P431L	MYOCD_ENST00000343344.4_Missense_Mutation_p.P431L|MYOCD_ENST00000395988.1_Missense_Mutation_p.P335L	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	431					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AACACGCTGCCCAATTACCAG	0.577000													117	116					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447443	226447443	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:226447443C>A	ENST00000272907.6	+	4	1723	c.1310C>A	c.(1309-1311)cCc>cAc	p.P437H	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	437	Pro-rich.																TCCACCTCTCCCTCCCCCGTC	0.647000													27	24					1.42536e-11	1.71137e-11	1	1	0
XIRP2	129446	broad.mit.edu	37	2	167760064	167760064	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:167760064T>A	ENST00000409195.1	+	2	161	c.72T>A	c.(70-72)agT>agA	p.S24R	XIRP2_ENST00000295237.9_Missense_Mutation_p.S24R|XIRP2_ENST00000409728.1_Missense_Mutation_p.S24R|XIRP2_ENST00000409043.1_Missense_Mutation_p.S24R|XIRP2_ENST00000409756.2_Missense_Mutation_p.S24R|XIRP2_ENST00000420519.1_Missense_Mutation_p.S24R	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATCAGAGAAGTGAGTGTCATC	0.488000													33	47					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46657029	46657029	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:46657029G>T	ENST00000544460.1	+	1	1418	c.1164G>T	c.(1162-1164)tgG>tgT	p.W388C	TDRD6_ENST00000316081.6_Missense_Mutation_p.W388C	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	388					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			GGAGAGGCTGGTCTCGGTCAC	0.493000													52	91					1.46357e-32	2.11986e-32	1	1	0
C14orf159	80017	broad.mit.edu	37	14	91662730	91662730	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:91662730A>C	ENST00000518868.1	+	13	1897	c.1207A>C	c.(1207-1209)Acg>Ccg	p.T403P	C14orf159_ENST00000523771.1_Missense_Mutation_p.T398P|C14orf159_ENST00000256324.10_Missense_Mutation_p.T403P|C14orf159_ENST00000522322.1_Missense_Mutation_p.T398P|C14orf159_ENST00000521077.2_Missense_Mutation_p.T403P|C14orf159_ENST00000520328.1_Missense_Mutation_p.T386P|C14orf159_ENST00000525393.2_Missense_Mutation_p.T274P|C14orf159_ENST00000523816.1_Missense_Mutation_p.T398P|C14orf159_ENST00000428926.2_Missense_Mutation_p.T398P|C14orf159_ENST00000412671.2_Missense_Mutation_p.T403P			Q7Z3D6	CN159_HUMAN	chromosome 14 open reading frame 159	398						mitochondrion				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		TGTTCTGAAGACGCAGATCCC	0.473000													9	19					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179411937	179411937	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:179411937T>C	ENST00000589042.1	-	340	94539	c.94315A>G	c.(94315-94317)Aaa>Gaa	p.K31439E	TTN_ENST00000591111.1_Missense_Mutation_p.K29798E|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.K22374E|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.K28871E|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.K22566E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.K22499E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29798	Fibronectin type-III 129.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAATGATTTTACTGCCACCA	0.453000													104	136					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48735816	48735816	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:48735816C>T	ENST00000285238.8	+	6	713	c.633C>T	c.(631-633)agC>agT	p.S211S	ABCC3_ENST00000427699.1_Silent_p.S211S	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	211					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CTGAGACCAGCGCTGGCTTTC	0.582000													50	104					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125506285	125506285	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:125506285C>A	ENST00000241305.3	-	14	2420	c.2266G>T	c.(2266-2268)Ggg>Tgg	p.G756W	CPXM2_ENST00000368854.3_Intron	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	756					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GAGGGTCACCCACGCTGTCGT	0.582000													33	35					6.00712e-18	7.9442e-18	1	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140755318	140755318	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:140755318T>G	ENST00000517434.1	+	1	1668	c.1668T>G	c.(1666-1668)aaT>aaG	p.N556K	PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACCAGAATGACAATGCGC	0.642000													155	91					0	0	1	0	0
STARD8	9754	broad.mit.edu	37	X	67939133	67939133	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:67939133C>A	ENST00000252336.6	+	6	1914	c.1542C>A	c.(1540-1542)atC>atA	p.I514I	STARD8_ENST00000374599.3_Silent_p.I594I|STARD8_ENST00000374597.3_Silent_p.I514I	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	514					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						CGCTGGAGATCAACCGGCAGT	0.607000													23	9					3.62473e-10	4.22018e-10	1	1	0
HAPLN1	1404	broad.mit.edu	37	5	82940381	82940381	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:82940381G>C	ENST00000274341.4	-	4	1426	c.576C>G	c.(574-576)gaC>gaG	p.D192E		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	192	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		CGTACAGCTGGTCGAAGGAGG	0.592000													40	21					0	0	1	0	0
CCT6P3	643180	broad.mit.edu	37	7	64498796	64498796	+	RNA	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:64498796G>T	ENST00000426828.1	+	0	59					NR_033416.1																						CGGTGGGAGCGGGTGGCCCGG	0.726000													4	19					0.217242	0.218139	1	1	0
MAGEA10	4109	broad.mit.edu	37	X	151303506	151303506	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:151303506G>A	ENST00000370323.4	-	4	903	c.587C>T	c.(586-588)cCc>cTc	p.P196L	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Missense_Mutation_p.P196L	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	196	MAGE.									endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GTGGCCAGTGGGATCCACTTC	0.488000													38	14					0	0	1	0	0
KIAA1257	57501	broad.mit.edu	37	3	128712000	128712000	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:128712000G>T	ENST00000265068.5	-	2	315	c.148C>A	c.(148-150)Cgc>Agc	p.R50S	KIAA1257_ENST00000511438.1_Missense_Mutation_p.R50S|KIAA1257_ENST00000510149.1_Intron	NM_020741.2	NP_065792.1	Q9ULG3	K1257_HUMAN	KIAA1257	50										breast(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(2)	14						CTGCACGGGCGGTCAGAGTCA	0.602000													22	79					1.64113e-05	1.76961e-05	1	1	0
UNC13C	440279	broad.mit.edu	37	15	54556445	54556445	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:54556445G>T	ENST00000545554.1	+	8	3528	c.3528G>T	c.(3526-3528)aaG>aaT	p.K1176N	UNC13C_ENST00000537900.1_Missense_Mutation_p.K1174N|UNC13C_ENST00000260323.11_Missense_Mutation_p.K1176N			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1176					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AAAGAATGAAGATCAGGGAGA	0.393000													6	7					0.00116845	0.00122026	1	1	0
RTN4IP1	84816	broad.mit.edu	37	6	107031225	107031225	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:107031225G>A	ENST00000369063.3	-	8	1526	c.1061C>T	c.(1060-1062)gCa>gTa	p.A354V	RTN4IP1_ENST00000498091.1_5'UTR|RTN4IP1_ENST00000539449.1_3'UTR	NM_032730.4	NP_116119.2	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1	354						mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		CACCAGTTCTGCAATGTCATC	0.468000													17	18					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79470766	79470766	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:79470766G>T	ENST00000370742.3	-	2	224	c.161C>A	c.(160-162)aCa>aAa	p.T54K		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	54	EGF-like 1.				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TTCACAAATTGTGACACCATT	0.373000													38	51					5.71845e-15	7.24734e-15	1	1	0
MAGEC1	9947	broad.mit.edu	37	X	140995990	140995990	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:140995990A>G	ENST00000285879.4	+	4	3086	c.2800A>G	c.(2800-2802)Atg>Gtg	p.M934V	MAGEC1_ENST00000406005.2_Start_Codon_SNP_p.M1V	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	934	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					AAAGGCAGAGATGCTGACGAA	0.473000										HNSCC(15;0.026)			117	45					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188223833	188223833	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:188223833T>G	ENST00000409998.1	-	13	1647	c.866A>C	c.(865-867)cAt>cCt	p.H289P	CALCRL_ENST00000410068.1_Missense_Mutation_p.H289P|AC007319.1_ENST00000412276.1_RNA|CALCRL_ENST00000392370.3_Missense_Mutation_p.H289P|AC007319.1_ENST00000453517.1_RNA			Q16602	CALRL_HUMAN	calcitonin receptor-like	289						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			GTAGAGGAGATGGGTATCAGA	0.303000													73	117					0	0	1	0	0
HBG2	3048	broad.mit.edu	37	11	5275521	5275521	+	Splice_Site	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:5275521C>A	ENST00000380259.2	-	7	1556		c.e7+1		HBG2_ENST00000336906.4_Splice_Site|HBG2_ENST00000380252.1_Splice_Site					hemoglobin, gamma G											endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	13		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTGGACTCACCTTGAAGTTC	0.498000													28	45					1.08312e-15	1.38715e-15	1	1	0
LAMA1	284217	broad.mit.edu	37	18	6943343	6943343	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:6943343G>A	ENST00000389658.3	-	62	8996	c.8903C>T	c.(8902-8904)aCc>aTc	p.T2968I		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2968	Laminin G-like 5.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACAGTGGCGGTTTTGGGCTC	0.443000													38	54					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8146456	8146456	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:8146456C>A	ENST00000315684.8	-	2	51	c.44G>T	c.(43-45)tGg>tTg	p.W15L	CTC1_ENST00000581671.1_Intron	NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	15					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						ATCCTCAAGCCAGGCTTGTTC	0.438000													20	16					8.34094e-07	9.18384e-07	1	1	0
CD1A	909	broad.mit.edu	37	1	158227272	158227272	+	Silent	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:158227272A>T	ENST00000289429.5	+	5	1478	c.945A>T	c.(943-945)atA>atT	p.I315I		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	315					antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	TTCTTCTGATAGGTCTTGCGC	0.443000													51	157					0	0	1	0	0
CRHR2	1395	broad.mit.edu	37	7	30695280	30695280	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:30695280G>T	ENST00000471646.1	-	10	1386	c.969C>A	c.(967-969)taC>taA	p.Y323*	CRHR2_ENST00000341843.4_Nonsense_Mutation_p.Y309*|CRHR2_ENST00000348438.4_Nonsense_Mutation_p.Y350*|CRHR2_ENST00000506074.2_Nonsense_Mutation_p.Y323*	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	323					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						AGAAGAGCATGTAGGTGATGC	0.607000													96	84					4.91162e-27	6.93517e-27	1	1	0
PSG5	5673	broad.mit.edu	37	19	43683276	43683276	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:43683276T>A	ENST00000599812.1	-	3	559	c.464A>T	c.(463-465)aAc>aTc	p.N155I	PSG5_ENST00000404580.1_Intron|PSG5_ENST00000342951.6_Intron|PSG5_ENST00000366175.3_Intron|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000407356.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	155	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				GGGGTTTAAGTTGCTACTGGA	0.512000													109	178					0	0	1	0	0
GGT5	2687	broad.mit.edu	37	22	24627431	24627431	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr22:24627431G>T	ENST00000327365.4	-	6	1238	c.822C>A	c.(820-822)ccC>ccA	p.P274P	GGT5_ENST00000418439.2_Silent_p.P197P|GGT5_ENST00000398292.3_Silent_p.P274P|GGT5_ENST00000263112.7_Silent_p.P242P	NM_001099781.1|NM_004121.2	NP_001093251.1|NP_004112.2	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5	274					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						AGTCCCCCAGGGGCACCTCCA	0.622000													3	6					0.004672	0.00476335	1	1	0
SPATA17	128153	broad.mit.edu	37	1	217947767	217947767	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:217947767C>G	ENST00000366933.4	+	7	666	c.611C>G	c.(610-612)cCt>cGt	p.P204R		NM_138796.2	NP_620151.1	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	204						cytoplasm	calmodulin binding			endometrium(1)|kidney(1)|large_intestine(9)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		CACCGAAGACCTAAAGTTAAG	0.438000													56	48					0	0	1	0	0
GPR39	2863	broad.mit.edu	37	2	133175182	133175182	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:133175182C>A	ENST00000329321.3	+	1	1036	c.567C>A	c.(565-567)ctC>ctA	p.L189L		NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	189						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ACCGGGGTCTCACTTGCAACC	0.627000													36	49					2.09667e-21	2.86623e-21	1	1	0
EPB41	2035	broad.mit.edu	37	1	29344777	29344777	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:29344777G>A	ENST00000343067.4	+	7	1074	c.947G>A	c.(946-948)gGa>gAa	p.G316E	EPB41_ENST00000373798.1_Missense_Mutation_p.G316E|EPB41_ENST00000373800.3_Missense_Mutation_p.G107E|EPB41_ENST00000356093.2_Missense_Mutation_p.G316E|EPB41_ENST00000349460.4_Missense_Mutation_p.G107E|EPB41_ENST00000347529.3_Missense_Mutation_p.G281E|EPB41_ENST00000398863.2_Missense_Mutation_p.G316E|EPB41_ENST00000373797.1_Missense_Mutation_p.G316E	NM_001166005.1	NP_001159477.1	P11171	41_HUMAN	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	316	FERM.				blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|urinary_tract(1)	14		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		ATAGTTGCAGGACGTCTGCCC	0.418000													34	51					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21721379	21721379	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:21721379G>T	ENST00000388958.3	+	12	1276	c.1275G>T	c.(1273-1275)aaG>aaT	p.K425N	OTOA_ENST00000388957.3_Missense_Mutation_p.K101N|OTOA_ENST00000286149.4_Missense_Mutation_p.K439N|OTOA_ENST00000388956.4_Missense_Mutation_p.K346N	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	439					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		GTTGGGCCAAGAGCCAGGTCA	0.498000													12	22					1.5842e-08	1.79576e-08	1	1	0
AURKC	6795	broad.mit.edu	37	19	57743544	57743544	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:57743544G>T	ENST00000302804.7	+	3	434	c.248G>T	c.(247-249)gGa>gTa	p.G83V	AURKC_ENST00000448930.1_Missense_Mutation_p.G49V|AURKC_ENST00000598785.1_Missense_Mutation_p.G49V|AURKC_ENST00000415300.2_Missense_Mutation_p.G64V|AURKC_ENST00000599062.1_Missense_Mutation_p.G80V	NM_001015878.1	NP_001015878.1	Q9UQB9	AURKC_HUMAN	aurora kinase C	83	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		GAGAAGGAAGGACTGGAGCAC	0.512000													19	25					5.26018e-13	6.42129e-13	1	1	0
CD300E	342510	broad.mit.edu	37	17	72608865	72608865	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:72608865A>G	ENST00000392619.1	-	4	661	c.626T>C	c.(625-627)cTg>cCg	p.L209P	CD300E_ENST00000328630.3_Missense_Mutation_p.L182P|CD300E_ENST00000426295.2_Missense_Mutation_p.L223P	NM_181449.2	NP_852114.2	Q496F6	CLM2_HUMAN	CD300e molecule	182						integral to membrane|plasma membrane	receptor activity			breast(1)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	19						GAGCAGGGGCAGCTTCAGAAG	0.617000													68	99					0	0	1	0	0
CCDC114	93233	broad.mit.edu	37	19	48806048	48806048	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:48806048C>A	ENST00000315396.7	-	10	1714	c.1032G>T	c.(1030-1032)aaG>aaT	p.K344N		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	344										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		GCTGCAACACCTTCTGCTGCT	0.622000													31	137					4.74835e-14	5.89507e-14	1	1	0
CACNG8	59283	broad.mit.edu	37	19	54483177	54483177	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:54483177G>C	ENST00000270458.2	+	3	527	c.424G>C	c.(424-426)Ggg>Cgg	p.G142R		NM_031895.5	NP_114101.4	Q8WXS5	CCG8_HUMAN	calcium channel, voltage-dependent, gamma subunit 8	142					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			kidney(1)|large_intestine(3)|lung(8)|urinary_tract(1)	13	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		GCTGCTGCTCGGGGGTGTGTG	0.637000													8	24					0	0	1	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130764823	130764823	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:130764823C>T	ENST00000509018.1	-	27	4757	c.4552G>A	c.(4552-4554)Gac>Aac	p.D1518N	RAPGEF6_ENST00000307984.5_Intron|FNIP1_ENST00000514667.1_Missense_Mutation_p.D1568N|RAPGEF6_ENST00000507093.1_Intron|RAPGEF6_ENST00000296859.6_Missense_Mutation_p.D1526N	NM_001164386.1|NM_016340.5	NP_001157858.1|NP_057424.3	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6	1518					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		TCCTTTAGGTCCGCTAAAGAA	0.493000													49	29					0	0	1	0	0
ROCK2	9475	broad.mit.edu	37	2	11337449	11337449	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:11337449C>T	ENST00000315872.6	-	27	3753	c.3305G>A	c.(3304-3306)cGa>cAa	p.R1102Q	ROCK2_ENST00000401753.1_Missense_Mutation_p.R859Q	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	1102					axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		CAGTTCAATTCGAATCTGGCT	0.368000													11	36					0	0	1	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86544177	86544177	+	Splice_Site	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:86544177C>A	ENST00000450689.2	-	13	1779		c.e13-1		KIAA1324L_ENST00000444627.1_Splice_Site|KIAA1324L_ENST00000490995.1_Splice_Site|KIAA1324L_ENST00000416314.1_Splice_Site|KIAA1324L_ENST00000297222.6_Splice_Site	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like							integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					TATTAATATCCTGAAATATAG	0.289000													7	19					0.00198382	0.00204836	1	1	0
KLK15	55554	broad.mit.edu	37	19	51330287	51330287	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:51330287G>T	ENST00000326856.4	-	4	454	c.325C>A	c.(325-327)Ctg>Atg	p.L109M	KLK15_ENST00000301421.2_Missense_Mutation_p.L110M|KLK15_ENST00000596931.1_Missense_Mutation_p.L109M|KLK15_ENST00000416184.1_Missense_Mutation_p.L110M|KLK15_ENST00000598239.1_Missense_Mutation_p.L110M	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	110	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		ACTAGGCGCAGCAACATGATG	0.692000													34	93					6.84511e-11	8.16492e-11	1	1	0
KMT2B	9757	broad.mit.edu	37	19	36223501	36223501	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:36223501C>T	ENST00000420124.1	+	28	6051	c.6051C>T	c.(6049-6051)caC>caT	p.H2017H	WBP7_ENST00000222270.7_Silent_p.H2017H|KMT2B_ENST00000607650.1_RNA																							GGAGCAGCCACGGGGGCCCGG	0.687000													17	28					0	0	1	0	0
ANKDD1A	348094	broad.mit.edu	37	15	65219136	65219136	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:65219136G>T	ENST00000380230.3	+	6	537	c.508G>T	c.(508-510)Ggg>Tgg	p.G170W	AC069368.3_ENST00000437723.1_Intron|ANKDD1A_ENST00000319580.8_3'UTR|ANKDD1A_ENST00000491145.1_3'UTR|ANKDD1A_ENST00000496660.1_Missense_Mutation_p.G79W|ANKDD1A_ENST00000395720.1_Missense_Mutation_p.G170W|ANKDD1A_ENST00000357698.3_Missense_Mutation_p.G170W|ANKDD1A_ENST00000395723.1_Missense_Mutation_p.G79W	NM_182703.3	NP_874362.3	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	170					signal transduction					NS(1)|endometrium(1)|large_intestine(10)|liver(2)|lung(4)|ovary(1)|prostate(2)	21						AGCTGAGCACGGGCAGCTGGA	0.622000													51	105					1.46156e-29	2.09614e-29	1	1	0
PCDHB11	56125	broad.mit.edu	37	5	140580935	140580935	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:140580935C>T	ENST00000354757.3	+	1	1588	c.1588C>T	c.(1588-1590)Cgc>Tgc	p.R530C	PCDHB11_ENST00000536699.1_Missense_Mutation_p.R165C	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		530	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTCGACTTCCGCGTGGGCGC	0.672000													114	63					0	0	1	0	0
FCGR3B	2215	broad.mit.edu	37	1	161599676	161599676	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:161599676C>T	ENST00000294800.3	-	3	484	c.211G>A	c.(211-213)Gcc>Acc	p.A71T	FCGR2B_ENST00000367962.4_Intron|FCGR3B_ENST00000367964.2_Missense_Mutation_p.A71T|FCGR2B_ENST00000428605.2_Intron|FCGR2B_ENST00000403078.3_Intron|FCGR3A_ENST00000540048.1_Intron|FCGR2B_ENST00000367960.5_Intron|FCGR3B_ENST00000531221.1_Missense_Mutation_p.A107T	NM_001244753.1|NM_001271035.1	NP_001231682.1|NP_001257964.1	O75015	FCG3B_HUMAN	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	71	Ig-like C2-type 1.				immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	18	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TAGCTCGAGGCCTGGCTTGAG	0.542000													67	107					0	0	1	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49351230	49351230	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:49351230T>C	ENST00000263265.6	-	14	2048	c.1493A>G	c.(1492-1494)cAg>cGg	p.Q498R	PLEKHA4_ENST00000355496.5_Missense_Mutation_p.Q473R	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	498						cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GGGCGGTTTCTGGGGGCCACC	0.592000													27	30					0	0	1	0	0
LYZ	4069	broad.mit.edu	37	12	69742211	69742211	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:69742211G>C	ENST00000261267.2	+	1	91	c.23G>C	c.(22-24)gGg>gCg	p.G8A	LYZ_ENST00000549690.1_Missense_Mutation_p.G8A|LYZ_ENST00000548839.1_Missense_Mutation_p.G8A	NM_000239.2	NP_000230.1	P61626	LYSC_HUMAN	lysozyme	8					cell wall macromolecule catabolic process|cytolysis|defense response to bacterium|inflammatory response	extracellular space	lysozyme activity|protein binding			endometrium(2)|lung(1)|upper_aerodigestive_tract(1)	4	all_epithelial(5;2.98e-35)|Lung NSC(4;9.93e-33)|all_lung(4;5.66e-31)|Breast(13;2.56e-06)|Esophageal squamous(21;0.187)		Epithelial(6;8.26e-19)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00503)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			ATTGTTCTGGGGCTTGTCCTC	0.493000													13	59					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76475683	76475683	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:76475683G>A	ENST00000389840.5	-	50	7866	c.7742C>T	c.(7741-7743)cCc>cTc	p.P2581L	DNAH17_ENST00000585328.1_Missense_Mutation_p.P2590L|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CTCCTGGCCGGGGAAGCTCAC	0.602000													89	104					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81568634	81568634	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:81568634C>A	ENST00000548058.1	+	8	2076	c.1166C>A	c.(1165-1167)gCc>gAc	p.A389D	ACSS3_ENST00000261206.3_Missense_Mutation_p.A388D|ACSS3_ENST00000548324.1_Missense_Mutation_p.A71D			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	389						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						GGAGTAGCTGCCTTGTTTACA	0.502000													10	40					0.000978159	0.00102594	1	1	0
OR8H1	219469	broad.mit.edu	37	11	56058145	56058145	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:56058145G>T	ENST00000313022.2	-	1	421	c.394C>A	c.(394-396)Cca>Aca	p.P132T		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	132					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					ATAATAACTGGGTAACGTAGA	0.443000													10	109					7.13841e-38	1.05915e-37	1	1	0
SALL3	27164	broad.mit.edu	37	18	76754127	76754127	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:76754127C>T	ENST00000536229.3	+	1	2446	c.1737C>T	c.(1735-1737)tgC>tgT	p.C579C	SALL3_ENST00000575389.2_Silent_p.C712C|SALL3_ENST00000537592.2_Silent_p.C712C			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	712					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCAAGATCTGCGGCCGCGCCT	0.662000													12	18					0	0	1	0	0
FKBP9L	360132	broad.mit.edu	37	7	55755579	55755579	+	RNA	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:55755579G>C	ENST00000455909.1	-	0	427					NR_027340.1|NR_027342.1				FK506 binding protein 9-like											endometrium(1)|kidney(1)|lung(3)	5						AACTTGCCCAGATCCCAGAAC	0.498000													48	39					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55223853	55223853	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:55223853A>G	ENST00000340465.2	+	6	955	c.869A>G	c.(868-870)cAa>cGa	p.Q290R		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	290						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTTCAAGTGCAATGTACCTGT	0.403000													42	78					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176852072	176852072	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:176852072C>A	ENST00000367654.2	-	20	3322	c.3309G>T	c.(3307-3309)atG>atT	p.M1103I	ASTN1_ENST00000367657.3_Missense_Mutation_p.M1095I|ASTN1_ENST00000424564.2_Missense_Mutation_p.M1095I|ASTN1_ENST00000361833.2_Missense_Mutation_p.M1095I			O14525	ASTN1_HUMAN	astrotactin 1	1103	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CCTGAGATGGCATTGCACAAG	0.488000													15	79					0.000422831	0.000444765	1	1	0
RELN	5649	broad.mit.edu	37	7	103243844	103243844	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:103243844C>T	ENST00000424685.2	-	24	3399	c.3240G>A	c.(3238-3240)gaG>gaA	p.E1080E	RELN_ENST00000343529.5_Silent_p.E1080E|RELN_ENST00000428762.1_Silent_p.E1080E			P78509	RELN_HUMAN	reelin	1080					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GCCAGTCAGACTCCCAGCCAT	0.483000													43	71					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39805043	39805043	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:39805043C>A	ENST00000248668.4	-	1	933	c.934G>T	c.(934-936)Gtg>Ttg	p.V312L		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	312	Ig-like.					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			TGGCCTTCCACCACCAGGGCC	0.706000													7	12					0.00198382	0.00204836	1	1	0
MAST1	22983	broad.mit.edu	37	19	12958691	12958691	+	Silent	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:12958691C>G	ENST00000251472.4	+	7	633	c.594C>G	c.(592-594)cgC>cgG	p.R198R	MAST1_ENST00000591495.1_Silent_p.R194R	NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	198					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						AGAAGCTGCGCGACTTTACCC	0.701000											OREG0025277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	8					0	0	1	0	0
PRSS55	203074	broad.mit.edu	37	8	10388887	10388887	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:10388887C>G	ENST00000328655.3	+	3	470	c.430C>G	c.(430-432)Ctt>Gtt	p.L144V	PRSS51_ENST00000523024.1_RNA|PRSS55_ENST00000522210.1_Missense_Mutation_p.L144V	NM_198464.3	NP_940866.2	Q6UWB4	PRS55_HUMAN	protease, serine, 55	144	Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)	31						CAGCATCATTCTTCACAAAGA	0.517000													6	290					0	0	1	0	0
R3HDM1	23518	broad.mit.edu	37	2	136399236	136399236	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:136399236T>A	ENST00000264160.4	+	15	1720	c.1350T>A	c.(1348-1350)caT>caA	p.H450Q	R3HDM1_ENST00000443537.2_Intron|R3HDM1_ENST00000329971.3_Intron|R3HDM1_ENST00000410054.1_Missense_Mutation_p.H394Q|R3HDM1_ENST00000409606.1_Missense_Mutation_p.H450Q|R3HDM1_ENST00000409478.1_Intron	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	450							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		TCAGCACTCATAGTTCTCTTT	0.522000													52	103					0	0	1	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123477329	123477329	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:123477329C>A	ENST00000529750.1	+	10	1234	c.907C>A	c.(907-909)Ccc>Acc	p.P303T	GRAMD1B_ENST00000322282.7_Missense_Mutation_p.P303T|GRAMD1B_ENST00000456860.2_Missense_Mutation_p.P310T	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	303						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		TGATGGGCTGCCCCTGGAGGA	0.562000													9	10					0.00448238	0.00458925	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141267547	141267547	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:141267547C>A	ENST00000389484.3	-	52	9319	c.8348G>T	c.(8347-8349)gGt>gTt	p.G2783V		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2783	LDL-receptor class A 17.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTCCCTTTCACCATCACAAAG	0.532000										TSP Lung(27;0.18)			32	100					4.90274e-10	5.67195e-10	1	1	0
KRTAP4-2	85291	broad.mit.edu	37	17	39334160	39334160	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:39334160A>C	ENST00000377726.2	-	1	300	c.257T>G	c.(256-258)tTc>tGc	p.F86C		NM_033062.3	NP_149051.1	Q9BYR5	KRA42_HUMAN	keratin associated protein 4-2	86	20 X 5 AA repeats OF C-C-[GRQVS]-[SPT]- [VSTQ].					keratin filament				kidney(2)|lung(4)|upper_aerodigestive_tract(1)	7		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			CTGGGGTCTGAAGCAGCTGGA	0.672000													22	104					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141771282	141771282	+	Silent	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:141771282A>G	ENST00000389484.3	-	14	3194	c.2223T>C	c.(2221-2223)ccT>ccC	p.P741P		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	741					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACAGTCCGAAAGGGTGGTTCA	0.348000										TSP Lung(27;0.18)			26	49					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179437569	179437569	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:179437569C>T	ENST00000589042.1	-	326	73514	c.73290G>A	c.(73288-73290)ctG>ctA	p.L24430L	TTN_ENST00000591111.1_Silent_p.L22789L|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000460472.2_Silent_p.L15365L|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Silent_p.L21862L|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Silent_p.L15557L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Silent_p.L15490L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22789	Fibronectin type-III 77.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTCAGCATCCAGTTCAATTT	0.522000													25	53					0	0	1	0	0
OR2T10	127069	broad.mit.edu	37	1	248757051	248757051	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:248757051T>A	ENST00000330500.2	-	1	49	c.19A>T	c.(19-21)Acc>Tcc	p.T7S		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCACCCAGGGTCTGGTTGGCC	0.463000													39	25					0	0	1	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530257	80530257	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:80530257G>T	ENST00000295057.3	-	2	1344	c.688C>A	c.(688-690)Ccg>Acg	p.P230T	CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000402739.4_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.P230T	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	230						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						ATGAGGCGCGGGAAGTGGGCG	0.582000										HNSCC(69;0.2)			56	151					5.47352e-35	8.05579e-35	1	1	0
SPTAN1	6709	broad.mit.edu	37	9	131351145	131351145	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:131351145G>T	ENST00000372739.3	+	21	3039	c.2929G>T	c.(2929-2931)Gac>Tac	p.D977Y	SPTAN1_ENST00000372731.4_Missense_Mutation_p.D977Y|SPTAN1_ENST00000358161.5_Missense_Mutation_p.D977Y	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	977	SH3.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GGCTCTCTACGACTATCAGGA	0.512000													34	25					9.17885e-22	1.26188e-21	1	1	0
ACTL7B	10880	broad.mit.edu	37	9	111618175	111618175	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:111618175C>T	ENST00000374667.3	-	1	1064	c.36G>A	c.(34-36)acG>acA	p.T12T		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	12						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						CACCCTGAGCCGTGCCCAGGG	0.657000													3	49					0	0	1	0	0
SKI	6497	broad.mit.edu	37	1	2235418	2235418	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:2235418C>T	ENST00000378536.4	+	4	1423	c.1351C>T	c.(1351-1353)Cag>Tag	p.Q451*		NM_003036.3	NP_003027.1	P12755	SKI_HUMAN	v-ski avian sarcoma viral oncogene homolog	451					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|kidney(2)|lung(5)|prostate(1)|stomach(1)	10	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		CACTTGCACCCAGCCTCGGAA	0.716000													6	13					0	0	1	0	0
C19orf54	284325	broad.mit.edu	37	19	41248439	41248439	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:41248439G>A	ENST00000378313.2	-	6	1074	c.955C>T	c.(955-957)Cgg>Tgg	p.R319W	C19orf54_ENST00000470681.1_3'UTR|C19orf54_ENST00000598485.2_Intron|C19orf54_ENST00000339153.3_Intron|C19orf54_ENST00000598729.1_Missense_Mutation_p.R147W	NM_198476.3	NP_940878.3	Q5BKX5	CS054_HUMAN	chromosome 19 open reading frame 54	319										breast(1)|lung(1)|urinary_tract(2)	4			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			TCAGTGGCCCGTGAGGGCGAG	0.647000													7	12					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25336852	25336852	+	RNA	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:25336852T>G	ENST00000546682.1	+	0	955				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						TGTTGGGTGCTGGTGGATCCC	0.502000													23	50					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123779052	123779052	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:123779052G>A	ENST00000422452.2	-	10	1880	c.1817C>T	c.(1816-1818)aCc>aTc	p.T606I	TENM1_ENST00000371130.3_Missense_Mutation_p.T606I	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		CATGATGCAGGTGCCGTGGCC	0.498000													130	45					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149524900	149524900	+	RNA	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:149524900G>C	ENST00000378016.2	+	0	14811							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCCCGGGGGAGCTGGGGCTCT	0.652000													15	26					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169500098	169500098	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:169500098C>T	ENST00000367796.3	-	15	5350	c.5149G>A	c.(5149-5151)Gcc>Acc	p.A1717T	F5_ENST00000367797.3_Missense_Mutation_p.A1712T			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1712	F5/8 type A 3.|Plastocyanin-like 5.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CGCTCAGTGGCATGCCATACG	0.458000													94	81					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70549771	70549771	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr13:70549771G>C	ENST00000377844.4	-	2	1420	c.661C>G	c.(661-663)Cga>Gga	p.R221G	KLHL1_ENST00000545028.1_Intron	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	221	BTB.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GGTATCTTTCGGTTCCCAACA	0.403000													45	93					0	0	1	0	0
FCGR3A	2214	broad.mit.edu	37	1	161518319	161518319	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:161518319C>T	ENST00000367969.3	-	3	502	c.319G>A	c.(319-321)Gcc>Acc	p.A107T	FCGR3A_ENST00000476031.1_5'UTR|FCGR3A_ENST00000436743.1_Missense_Mutation_p.A71T|FCGR3A_ENST00000443193.1_Missense_Mutation_p.A106T|FCGR3A_ENST00000540048.1_Missense_Mutation_p.A71T	NM_000569.6	NP_000560.5	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	71	Ig-like C2-type 2.				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TAGCTCGAGGCCTGGCTTGAG	0.557000													74	542					0	0	1	0	0
IGLV8-61	28774	broad.mit.edu	37	22	22453565	22453565	+	RNA	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr22:22453565C>T	ENST00000390283.2	+	0	357																											ATCACGGGGGCCCAGGCAGAT	0.498000													35	76					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15789122	15789122	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:15789122T>C	ENST00000550308.1	+	3	630	c.250T>C	c.(250-252)Tat>Cat	p.Y84H	CYP4F12_ENST00000324632.9_Missense_Mutation_p.Y84H	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					GTCGGCCACCTATTCCCAGGG	0.512000													60	142					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121930047	121930047	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:121930047C>A	ENST00000265922.3	-	8	2062	c.1601G>T	c.(1600-1602)cGc>cTc	p.R534L	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		534					cell cycle arrest|cell death	cytoplasm	protein binding	p.R534H(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						GAAGTCCATGCGGTTCTTGTT	0.552000													21	36					1.96292e-10	2.30375e-10	1	1	0
NCAM2	4685	broad.mit.edu	37	21	22746196	22746196	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr21:22746196G>T	ENST00000400546.1	+	9	1307	c.1058G>T	c.(1057-1059)cGt>cTt	p.R353L	NCAM2_ENST00000284894.7_Missense_Mutation_p.R211L|NCAM2_ENST00000535285.1_Missense_Mutation_p.R378L	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	353	Ig-like C2-type 4.				neuron cell-cell adhesion	integral to membrane|plasma membrane		p.R353L(1)		breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		CTGGACGGCCGTATCGAAGTC	0.408000													37	58					3.61848e-18	4.79399e-18	1	1	0
KCNH8	131096	broad.mit.edu	37	3	19575380	19575380	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:19575380C>T	ENST00000328405.2	+	16	3379	c.3113C>T	c.(3112-3114)tCg>tTg	p.S1038L		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	1038	Ser-rich.					integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						TGCTCCTCTTCGGAAACATCT	0.468000													71	48					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576355	33576355	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:33576355G>T	ENST00000504830.1	-	19	4111	c.3776C>A	c.(3775-3777)cCc>cAc	p.P1259H	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.P1174H	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1259	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CTTTCCTGAGGGTTCTGGCTG	0.512000										HNSCC(64;0.19)			35	299					1.04352e-10	1.23865e-10	1	1	0
EVX2	344191	broad.mit.edu	37	2	176946954	176946954	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:176946954G>A	ENST00000308618.4	-	2	787	c.651C>T	c.(649-651)cgC>cgT	p.R217R		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	217						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		GCTCGCACCGGCGGGGCCGCG	0.657000													15	12					0	0	1	0	0
MRGBP	55257	broad.mit.edu	37	20	61428574	61428574	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:61428574G>T	ENST00000370487.3	+	2	332	c.261G>T	c.(259-261)atG>atT	p.M87I		NM_018270.4	NP_060740.1			MRG/MORF4L binding protein																		TGTACGACATGCAGGCGCTGG	0.622000													24	42					6.36457e-07	7.03961e-07	1	1	0
CCDC129	223075	broad.mit.edu	37	7	31691586	31691586	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:31691586G>T	ENST00000319386.3	+	13	3294	c.2301G>T	c.(2299-2301)gaG>gaT	p.E767D	CCDC129_ENST00000409210.1_Missense_Mutation_p.E823D|CCDC129_ENST00000451887.2_Missense_Mutation_p.E941D|CCDC129_ENST00000407970.3_Missense_Mutation_p.E915D			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	915										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						CGTTACGTGAGGCCCTGAGGC	0.483000													3	0					1	1	1	1	0
CCNB3	85417	broad.mit.edu	37	X	50052792	50052792	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:50052792G>T	ENST00000376042.1	+	6	1921	c.1623G>T	c.(1621-1623)gaG>gaT	p.E541D	CCNB3_ENST00000348603.2_Intron|CCNB3_ENST00000276014.7_Missense_Mutation_p.E541D|CCNB3_ENST00000376038.1_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	541					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					CCACACAAGAGATGATGTCCA	0.373000													17	6					0.00400662	0.00411369	1	1	0
PCDH17	27253	broad.mit.edu	37	13	58209108	58209108	+	Silent	SNP	C	C	A	rs147572809	byFrequency	TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr13:58209108C>A	ENST00000377918.3	+	1	2454	c.2428C>A	c.(2428-2430)Cgg>Agg	p.R810R		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	810					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CAGCTCGCCCCGGTCGGAGGT	0.632000													7	19					0.0293803	0.0296648	1	1	0
SHD	56961	broad.mit.edu	37	19	4290529	4290529	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:4290529A>T	ENST00000543264.2	+	6	2385	c.922A>T	c.(922-924)Agc>Tgc	p.S308C	SHD_ENST00000599689.1_Missense_Mutation_p.S268C	NM_020209.3	NP_064594.3	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming protein D	308	SH2.									breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|stomach(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCCTTCCCCAGCGTGCCCGA	0.672000													39	84					0	0	1	0	0
OR13F1	138805	broad.mit.edu	37	9	107267262	107267262	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:107267262C>G	ENST00000334726.2	+	1	808	c.719C>G	c.(718-720)aCg>aGg	p.T240R		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						GCCTTTTCAACGTGCACAGCC	0.473000													7	103					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216052140	216052140	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:216052140G>A	ENST00000366943.2	-	42	8910	c.8524C>T	c.(8524-8526)Caa>Taa	p.Q2842*	USH2A_ENST00000307340.3_Nonsense_Mutation_p.Q2842*			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2842	Fibronectin type-III 15.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GATGGTGGTTGCCAAGAAATC	0.423000										HNSCC(13;0.011)			9	45					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22749478	22749478	+	RNA	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:22749478A>G	ENST00000503442.1	+	0	377				GBA3_ENST00000511446.1_RNA|GBA3_ENST00000508166.1_RNA	NM_001128432.2	NP_001121904.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AAGGCTATCCATCATCGAGGC	0.388000													7	8					0	0	1	0	0
ANKRD24	170961	broad.mit.edu	37	19	4216579	4216579	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:4216579G>A	ENST00000600132.1	+	18	1698	c.1422G>A	c.(1420-1422)caG>caA	p.Q474Q	ANKRD24_ENST00000318934.4_Silent_p.Q474Q|ANKRD24_ENST00000262970.5_Silent_p.Q564Q	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	474										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		ACGAGACACAGATGGAAGTGG	0.602000													6	11					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141208161	141208161	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:141208161C>A	ENST00000389484.3	-	63	11004	c.10033G>T	c.(10033-10035)Gga>Tga	p.G3345*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3345	LDL-receptor class A 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.G3345R(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCATCAGATCCATCACCACAG	0.348000										TSP Lung(27;0.18)			16	35					1.55795e-14	1.96086e-14	1	1	0
DPY19L1	23333	broad.mit.edu	37	7	34981467	34981467	+	Silent	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:34981467T>C	ENST00000310974.4	-	18	1524	c.1380A>G	c.(1378-1380)gcA>gcG	p.A460A		NM_015283.1	NP_056098.1	Q2PZI1	D19L1_HUMAN	dpy-19-like 1 (C. elegans)	460						integral to membrane				endometrium(3)|kidney(5)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	31						GGGCTGTATATGCTAACAATT	0.353000													29	21					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41553999	41553999	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:41553999G>T	ENST00000396942.1	-	26	2925	c.2842C>A	c.(2842-2844)Cgc>Agc	p.R948S	ANK1_ENST00000265709.8_Missense_Mutation_p.R989S|ANK1_ENST00000347528.4_Missense_Mutation_p.R948S|ANK1_ENST00000352337.4_Missense_Mutation_p.R948S|ANK1_ENST00000379758.2_Missense_Mutation_p.R948S|ANK1_ENST00000289734.7_Missense_Mutation_p.R948S|ANK1_ENST00000396945.1_Missense_Mutation_p.R948S			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	948	ZU5.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CAGGTGATGCGGGTGGGCGCT	0.687000													17	52					2.4624e-09	2.82634e-09	1	1	0
RBM47	54502	broad.mit.edu	37	4	40440638	40440638	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:40440638G>T	ENST00000319592.4	-	4	982	c.273C>A	c.(271-273)ttC>ttA	p.F91L	RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381793.2_Missense_Mutation_p.F91L|RBM47_ENST00000295971.7_Missense_Mutation_p.F91L|RBM47_ENST00000381795.6_Missense_Mutation_p.F91L|RBM47_ENST00000514014.1_Missense_Mutation_p.F53L			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	91	RRM 1.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CCACGGCCTCGAACACGGGCA	0.672000													38	27					1.04594e-18	1.39586e-18	1	1	0
SPEF2	79925	broad.mit.edu	37	5	35712924	35712924	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:35712924T>A	ENST00000440995.2	+	20	2835	c.2835T>A	c.(2833-2835)caT>caA	p.H945Q	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.H950Q			Q9C093	SPEF2_HUMAN	sperm flagellar 2	950					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAGCCCCGCATGGTAAGCAAG	0.358000													40	21					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79320286	79320286	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:79320286T>G	ENST00000428286.1	-	8	7027	c.5827A>C	c.(5827-5829)Agt>Cgt	p.S1943R	PRUNE2_ENST00000376718.3_Missense_Mutation_p.S2302R			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2302					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TCGCTGAAACTGTGGTCAAAG	0.483000													35	34					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21975224	21975224	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:21975224T>A	ENST00000382254.1	-	6	1588	c.502A>T	c.(502-504)Act>Tct	p.T168S	CDH12_ENST00000504376.2_Missense_Mutation_p.T168S|CDH12_ENST00000522262.1_Missense_Mutation_p.T168S	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	168	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TCTGGAACAGTAGCAACATAA	0.398000										HNSCC(59;0.17)			29	176					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86089629	86089629	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:86089629G>T	ENST00000330753.4	+	2	2538	c.1771G>T	c.(1771-1773)Gca>Tca	p.A591S	FLRT2_ENST00000554746.1_Missense_Mutation_p.A591S	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	591					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TTATTGCGAGGCAGGCACCAA	0.483000													82	135					4.34595e-34	6.3578e-34	1	1	0
IQGAP2	10788	broad.mit.edu	37	5	75866432	75866432	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:75866432G>C	ENST00000274364.6	+	4	628	c.331G>C	c.(331-333)Gat>Cat	p.D111H	IQGAP2_ENST00000379730.3_5'UTR	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	111	CH.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		TCGACACACAGATAATACCGT	0.438000													46	31					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142482981	142482981	+	RNA	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:142482981A>T	ENST00000430863.1	-	0	1918					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		CAGGAATTTGAGGAGGATCAT	0.657000													12	12					0	0	1	0	0
AK5	26289	broad.mit.edu	37	1	77752771	77752771	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:77752771C>A	ENST00000344720.5	+	2	1154	c.128C>A	c.(127-129)cCa>cAa	p.P43Q	AK5_ENST00000354567.2_Missense_Mutation_p.P69Q|AK5_ENST00000317704.4_3'UTR	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	69					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						ACCTTACCTCCACTAAATGGA	0.358000													25	56					5.45024e-15	6.93149e-15	1	1	0
HIVEP3	59269	broad.mit.edu	37	1	42047048	42047048	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:42047048G>A	ENST00000372584.1	-	3	4435	c.3421C>T	c.(3421-3423)Cca>Tca	p.P1141S	HIVEP3_ENST00000429157.2_Missense_Mutation_p.P1141S|HIVEP3_ENST00000372583.1_Missense_Mutation_p.P1141S|HIVEP3_ENST00000247584.5_Missense_Mutation_p.P1141S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1141					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GAGACTGGTGGGGGCAGGTAT	0.602000													48	123					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31374634	31374634	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:31374634G>A	ENST00000268296.4	+	14	1770	c.1649G>A	c.(1648-1650)cGg>cAg	p.R550Q	ITGAX_ENST00000562522.1_Missense_Mutation_p.R550Q	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	550					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity	p.R550Q(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						GAGGAGAACCGGGGTGCTGTC	0.632000													84	166					0	0	1	0	0
SNX7	51375	broad.mit.edu	37	1	99157183	99157183	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:99157183G>C	ENST00000370189.5	+	5	739	c.375G>C	c.(373-375)ttG>ttC	p.L125F	SNX7_ENST00000306121.3_Missense_Mutation_p.L189F|SNX7_ENST00000529992.1_Intron			Q9UNH6	SNX7_HUMAN	sorting nexin 7	125	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	13		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		ATAAATTTTTGAACCGAATTG	0.338000													12	25					0	0	1	0	0
NLGN1	22871	broad.mit.edu	37	3	173998518	173998518	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:173998518G>T	ENST00000457714.1	+	7	2326	c.1897G>T	c.(1897-1899)Gac>Tac	p.D633Y	NLGN1_ENST00000401917.3_Missense_Mutation_p.D673Y|NLGN1_ENST00000361589.4_Missense_Mutation_p.D633Y|NLGN1_ENST00000545397.1_Missense_Mutation_p.D633Y	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	650					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GCCATCAACTGACATCACTTT	0.433000													67	142					3.8128e-34	5.58905e-34	1	1	0
ATG2B	55102	broad.mit.edu	37	14	96783634	96783634	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:96783634C>A	ENST00000359933.4	-	20	3951	c.3058G>T	c.(3058-3060)Gag>Tag	p.E1020*		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1020										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AAAGTCTCCTCCTCAGATCCA	0.328000													21	4					1.96292e-10	2.30375e-10	1	1	0
IPO13	9670	broad.mit.edu	37	1	44415343	44415343	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:44415343C>T	ENST00000372343.3	+	2	1001	c.339C>T	c.(337-339)gcC>gcT	p.A113A		NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	113					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CCCGCTTTGCCAGTGGCTCCA	0.552000													11	61					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40077286	40077286	+	Splice_Site	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:40077286T>C	ENST00000324616.5	+	9	1440	c.1286_splice	c.e9+1	p.M429_splice	C12orf40_ENST00000405531.3_Splice_Site_p.M429_splice|C12orf40_ENST00000398716.1_Splice_Site_p.I352_splice	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	429										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						GCAAACTCTATGTAAGTTTTT	0.328000													7	14					0	0	1	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47221257	47221257	+	Splice_Site	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:47221257C>T	ENST00000296861.2	-	4	1637	c.1243_splice	c.e4-1	p.G415_splice		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	415	Death.				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			GATATCGATACCTACACCAGA	0.433000													20	45					0	0	1	0	0
MS4A2	2206	broad.mit.edu	37	11	59860322	59860322	+	Splice_Site	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:59860322G>C	ENST00000278888.3	+	4	480		c.e4+1			NM_000139.4	NP_000130.1	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member 2						cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			endometrium(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)	17		all_epithelial(135;0.245)			Omalizumab(DB00043)	AACATATCTGGTGAGTTGCCC	0.348000													13	20					0	0	1	0	0
SNX7	51375	broad.mit.edu	37	1	99164286	99164286	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:99164286A>G	ENST00000370189.5	+	7	1035	c.671A>G	c.(670-672)tAt>tGt	p.Y224C	SNX7_ENST00000306121.3_Missense_Mutation_p.Y288C|SNX7_ENST00000529992.1_Missense_Mutation_p.Y233C			Q9UNH6	SNX7_HUMAN	sorting nexin 7	224					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	13		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		ATGAAAGAATATGGCCCAATT	0.348000													17	17					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890361	229890361	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:229890361G>T	ENST00000392054.3	-	4	1073	c.734C>A	c.(733-735)tCc>tAc	p.S245Y	PID1_ENST00000354069.6_Missense_Mutation_p.S247Y|PID1_ENST00000392055.3_Missense_Mutation_p.S214Y|PID1_ENST00000482518.2_Intron|PID1_ENST00000409462.1_Missense_Mutation_p.S165Y	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	247	PID.					cytoplasm		p.S245F(1)		breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		GCCATCATCGGATTCCAATTC	0.498000													41	70					4.67007e-22	6.43235e-22	1	1	0
TSSK2	23617	broad.mit.edu	37	22	19119173	19119173	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr22:19119173C>G	ENST00000399635.2	+	1	853	c.261C>G	c.(259-261)taC>taG	p.Y87*	DGCR14_ENST00000252137.6_3'UTR	NM_053006.4	NP_443732.3	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	87	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(2)|prostate(4)|stomach(1)	11	Colorectal(54;0.0993)					GACGGATCTACATCATCATGG	0.552000													23	36					0	0	1	0	0
SMO	6608	broad.mit.edu	37	7	128852125	128852125	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:128852125G>T	ENST00000249373.3	+	12	2477	c.2197G>T	c.(2197-2199)Gtc>Ttc	p.V733F	RP11-286H14.8_ENST00000466717.1_RNA	NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	733					adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						GTGGACCCTGGTCTCCAACCC	0.667000			Mis		skin basal cell								8	27					0.00307968	0.0031709	1	1	0
SCG5	6447	broad.mit.edu	37	15	32972061	32972061	+	Silent	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:32972061T>C	ENST00000300175.4	+	3	431	c.321T>C	c.(319-321)ttT>ttC	p.F107F	SCG5_ENST00000494364.1_Silent_p.F107F|SCG5_ENST00000497208.1_Silent_p.F107F|SCG5_ENST00000498069.1_3'UTR|SCG5_ENST00000413748.2_Silent_p.F107F	NM_001144757.1	NP_001138229.1	P05408	7B2_HUMAN	secretogranin V (7B2 protein)	107					intracellular protein transport|neuropeptide signaling pathway|peptide hormone processing|regulation of hormone secretion	extracellular region|stored secretory granule	enzyme inhibitor activity|GTP binding|unfolded protein binding			lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	6		all_lung(180;7.32e-08)		all cancers(64;6.48e-17)|Epithelial(43;1.23e-11)|GBM - Glioblastoma multiforme(186;1.39e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0212)		CTAAGGACTTTAGTGAGGATC	0.498000													55	166					0	0	1	0	0
KLRC1	3821	broad.mit.edu	37	12	10601978	10601978	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:10601978C>T	ENST00000544822.1	-	6	734	c.347G>A	c.(346-348)tGt>tAt	p.C116Y	KLRC1_ENST00000359151.3_Missense_Mutation_p.C116Y|KLRC1_ENST00000536188.1_Missense_Mutation_p.C116Y|KLRC1_ENST00000408006.3_Missense_Mutation_p.C98Y|KLRC1_ENST00000347831.5_Missense_Mutation_p.C98Y	NM_213658.2	NP_998823.1	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C, member 1	116					cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|skin(1)	16						ACAATGGCCACAATGACGTGC	0.343000													82	130					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64422299	64422299	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:64422299G>T	ENST00000262043.3	+	16	5155	c.4815G>T	c.(4813-4815)ttG>ttT	p.L1605F	PHF3_ENST00000393387.1_Missense_Mutation_p.L1605F			Q92576	PHF3_HUMAN	PHD finger protein 3	1605					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AGAATAATTTGCAAGATAACC	0.328000													23	37					3.62473e-10	4.22018e-10	1	1	0
C9orf135	138255	broad.mit.edu	37	9	72521027	72521027	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:72521027C>T	ENST00000377197.3	+	6	752	c.665C>T	c.(664-666)aCt>aTt	p.T222I	C9orf135_ENST00000527647.1_3'UTR|C9orf135_ENST00000466872.2_3'UTR	NM_001010940.1	NP_001010940.1	Q5VTT2	CI135_HUMAN	chromosome 9 open reading frame 135	222						integral to membrane				endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						TATCCCTTGACTAGTGGGCCT	0.338000													14	64					0	0	1	0	0
FOS	2353	broad.mit.edu	37	14	75747367	75747367	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:75747367A>C	ENST00000303562.4	+	3	707	c.498A>C	c.(496-498)caA>caC	p.Q166H	FOS_ENST00000555686.1_Missense_Mutation_p.Q52H|FOS_ENST00000555242.1_Missense_Mutation_p.Q166H|FOS_ENST00000535987.1_Intron|FOS_ENST00000555347.1_Missense_Mutation_p.Q18H	NM_005252.3	NP_005243.1	P01100	FOS_HUMAN	FBJ murine osteosarcoma viral oncogene homolog	166	Leucine-zipper.				cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		ATACACTCCAAGCGGTAGGTA	0.478000													21	32					0	0	1	0	0
VTA1	51534	broad.mit.edu	37	6	142525193	142525193	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:142525193A>G	ENST00000367630.4	+	7	827	c.769A>G	c.(769-771)Att>Gtt	p.I257V	VTA1_ENST00000452973.2_Intron|VTA1_ENST00000367621.1_Missense_Mutation_p.I199V	NM_016485.3	NP_057569.2	Q9NP79	VTA1_HUMAN	vesicle (multivesicular body) trafficking 1	257	Interaction with VPS4B (By similarity).				cellular membrane organization|endosome transport|protein transport	cytosol|endosome membrane	protein binding			endometrium(2)|large_intestine(1)|lung(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;1.34e-05)|GBM - Glioblastoma multiforme(68;0.00182)		TTTCAATACAATTTCCCAGGG	0.373000													22	40					0	0	1	0	0
CPPED1	55313	broad.mit.edu	37	16	12798821	12798821	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:12798821G>T	ENST00000381774.4	-	3	615	c.375C>A	c.(373-375)agC>agA	p.S125R	CPPED1_ENST00000433677.2_Intron|CPPED1_ENST00000261660.4_Intron	NM_018340.2	NP_060810.2	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain containing 1	125							hydrolase activity|metal ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|urinary_tract(1)	18						CATGGTTGCCGCTGACAAGGA	0.637000													29	75					3.65163e-15	4.66029e-15	1	1	0
ZNF347	84671	broad.mit.edu	37	19	53645668	53645668	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:53645668G>A	ENST00000452676.2	-	5	842	c.416C>T	c.(415-417)aCa>aTa	p.T139I	ZNF347_ENST00000334197.7_Missense_Mutation_p.T138I|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000601469.2_Missense_Mutation_p.T139I	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		AAGGCCATGTGTATTTTTCTG	0.418000													45	59					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25551136	25551136	+	Splice_Site	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:25551136A>T	ENST00000329474.6	+	27	2696		c.e27-1			NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A						actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						GCTGCATTGCAGGCGTTGCTT	0.488000													51	88					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79356840	79356840	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:79356840T>C	ENST00000419573.3	-	2	579	c.305A>G	c.(304-306)gAg>gGg	p.E102G	RASGRF1_ENST00000558480.2_Missense_Mutation_p.E102G|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	102	PH 1.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TTTCTGGTTCTCATGGCTGAA	0.493000													4	217					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149482235	149482235	+	RNA	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:149482235C>A	ENST00000378016.2	+	0	2909							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGCTGTGTGCCTCCTGACCTC	0.637000													53	59					1.63038e-21	2.23297e-21	1	1	0
OR2G2	81470	broad.mit.edu	37	1	247752567	247752567	+	Silent	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:247752567G>C	ENST00000320065.1	+	1	906	c.906G>C	c.(904-906)ggG>ggC	p.G302G	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AGGTGAAAGGGGCATTAAAGA	0.363000													36	174					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1272362	1272362	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:1272362G>T	ENST00000310581.5	-	7	2377	c.2320C>A	c.(2320-2322)Cga>Aga	p.R774R	TERT_ENST00000508104.2_Intron|TERT_ENST00000334602.6_Silent_p.R774R|TERT_ENST00000296820.5_Intron	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	774	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACGAACTGTCGCATGTACGGC	0.642000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				5	42					3.59834e-05	3.86861e-05	1	1	0
FAT2	2196	broad.mit.edu	37	5	150911310	150911310	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:150911310C>A	ENST00000261800.5	-	13	9661	c.9649G>T	c.(9649-9651)Gtg>Ttg	p.V3217L		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	3217	Cadherin 28.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCAGGAACACGGGCAGGTAG	0.677000													53	25					2.72333e-11	3.25907e-11	1	1	0
RIMS2	9699	broad.mit.edu	37	8	105261717	105261717	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:105261717G>T	ENST00000507740.1	+	20	3270	c.3034G>T	c.(3034-3036)Gac>Tac	p.D1012Y	RIMS2_ENST00000436393.2_Missense_Mutation_p.D1216Y|RIMS2_ENST00000262231.10_Missense_Mutation_p.D1037Y|RIMS2_ENST00000339750.2_Missense_Mutation_p.D134Y|RIMS2_ENST00000406091.3_Missense_Mutation_p.D1198Y	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1260					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TCCATTAGGTGACATTCAGGT	0.433000										HNSCC(12;0.0054)			12	40					3.07112e-06	3.36119e-06	1	1	0
AOC4P	90586	broad.mit.edu	37	17	41020792	41020792	+	RNA	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:41020792C>T	ENST00000585538.1	+	0	1631					NR_002773.1																						CAGCATTCCCCTTTGGTGCTG	0.537000													11	19					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53227957	53227957	+	Missense_Mutation	SNP	G	G	T	rs142757937	byFrequency	TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:53227957G>T	ENST00000330553.5	-	1	122	c.88C>A	c.(88-90)Cgc>Agc	p.R30S		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	30	Head.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AAGCTGGTGCGGGCCTGGGAC	0.647000													30	51					4.22769e-11	5.05109e-11	1	1	0
AXDND1	126859	broad.mit.edu	37	1	179452356	179452356	+	Splice_Site	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:179452356C>T	ENST00000367618.3	+	18	2478	c.2091_splice	c.e18+1	p.H697_splice	AL160286.1_ENST00000600581.1_Intron|AXDND1_ENST00000457238.2_3'UTR	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	697										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						TTCAGCACCACGTATGTACTT	0.373000													7	116					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197029575	197029575	+	Silent	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:197029575A>G	ENST00000367412.1	-	5	769	c.726T>C	c.(724-726)caT>caC	p.H242H		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	242	Sushi 4.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						AATAATTTTCATGACAGAAAA	0.303000													16	67					0	0	1	0	0
RPL31P11	641311	broad.mit.edu	37	1	161654957	161654957	+	RNA	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:161654957G>A	ENST00000426558.1	-	0	85					NR_002595.1																						GTTGATGGCAGAACGGCCCTT	0.547000													12	29					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100279	168100279	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:168100279C>A	ENST00000409195.1	+	9	2466	c.2377C>A	c.(2377-2379)Cga>Aga	p.R793R	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Silent_p.R793R|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409273.1_Silent_p.R571R|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	618					actin cytoskeleton organization	cell junction	actin binding	p.R793*(1)		NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TAAAGTTGTCCGAGGAATATC	0.403000													32	63					2.85442e-18	3.79549e-18	1	1	0
IFT122	55764	broad.mit.edu	37	3	129183607	129183607	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:129183607C>T	ENST00000296266.3	+	8	891	c.699C>T	c.(697-699)atC>atT	p.I233I	IFT122_ENST00000504021.1_Silent_p.I135I|IFT122_ENST00000440957.2_Silent_p.I32I|IFT122_ENST00000431818.2_Silent_p.I32I|IFT122_ENST00000347300.2_Silent_p.I182I|IFT122_ENST00000507564.1_Silent_p.I233I|IFT122_ENST00000348417.2_Silent_p.I182I|IFT122_ENST00000349441.2_Silent_p.I130I	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	182					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TATGGTCCATCTGCTGGAACC	0.488000													25	114					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87765302	87765302	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:87765302T>A	ENST00000398204.4	+	14	1499	c.1176T>A	c.(1174-1176)tgT>tgA	p.C392*	ADAM22_ENST00000398209.3_Nonsense_Mutation_p.C392*|ADAM22_ENST00000398201.4_Nonsense_Mutation_p.C392*|ADAM22_ENST00000315984.7_Nonsense_Mutation_p.C392*|ADAM22_ENST00000265727.7_Nonsense_Mutation_p.C392*	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	392	Peptidase M12B.				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TAGGTGAATGTAAATGCGAGG	0.378000													20	31					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7677154	7677154	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:7677154C>T	ENST00000446248.2	+	13	1957	c.1856C>T	c.(1855-1857)cCg>cTg	p.P619L	CAMSAP3_ENST00000160298.4_Missense_Mutation_p.P592L	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	592					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						ACTCCGGCCCCGCCGGAGGCC	0.627000													3	7					0	0	1	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70744247	70744247	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:70744247G>T	ENST00000260126.3	-	2	1368	c.662C>A	c.(661-663)cCc>cAc	p.P221H	SLCO5A1_ENST00000530307.1_Missense_Mutation_p.P221H|SLCO5A1_ENST00000524945.1_Missense_Mutation_p.P221H|SLCO5A1_ENST00000528658.1_5'UTR	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	221						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GATCTGGTAGGGGGGCGAGAT	0.677000													13	37					1.61879e-10	1.90908e-10	1	1	0
PODN	127435	broad.mit.edu	37	1	53544461	53544461	+	Missense_Mutation	SNP	C	C	A	rs145236540		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:53544461C>A	ENST00000371500.3	+	10	1707	c.1366C>A	c.(1366-1368)Cgc>Agc	p.R456S	PODN_ENST00000312553.5_Missense_Mutation_p.R475S|RP11-334A14.5_ENST00000447867.1_RNA|PODN_ENST00000395871.2_Missense_Mutation_p.R333S	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	427					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding	p.R475C(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						CGACGCCTTCCGCAAGCTGCG	0.642000													31	98					4.74835e-14	5.89507e-14	1	1	0
EPHA7	2045	broad.mit.edu	37	6	94066616	94066616	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:94066616G>T	ENST00000369303.4	-	5	1327	c.1143C>A	c.(1141-1143)ccC>ccA	p.P381P		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	381	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TACTCCCACAGGGAACACATT	0.483000													23	42					1.22574e-08	1.39375e-08	1	1	0
DHX34	9704	broad.mit.edu	37	19	47865833	47865833	+	Silent	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:47865833G>C	ENST00000328771.4	+	6	1825	c.1476G>C	c.(1474-1476)gcG>gcC	p.A492A	DHX34_ENST00000471451.1_Intron	NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	492	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		AGGGCCGGGCGGGCCGCACGG	0.647000													6	26					0	0	1	0	0
PBX2	5089	broad.mit.edu	37	6	32157637	32157637	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:32157637C>G	ENST00000375050.4	-	1	326	c.56G>C	c.(55-57)gGa>gCa	p.G19A		NM_002586.4	NP_002577.2	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	19							transcription factor binding			endometrium(1)|kidney(1)|lung(9)|ovary(1)|prostate(2)	14						ACTCACCAATCCCAggccccc	0.781000													6	12					0	0	1	0	0
CWC25	54883	broad.mit.edu	37	17	36958448	36958448	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:36958448A>G	ENST00000225428.4	-	10	1472	c.1175T>C	c.(1174-1176)cTg>cCg	p.L392P	CWC25_ENST00000536127.1_Missense_Mutation_p.L329P	NM_017748.3	NP_060218.1	Q9NXE8	CWC25_HUMAN	CWC25 spliceosome-associated protein homolog (S. cerevisiae)	392										central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	14						TGCACTCTCCAGCTTCATGCG	0.443000													11	23					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58978655	58978655	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:58978655T>A	ENST00000361050.3	-	1	1769	c.1684A>T	c.(1684-1686)Agc>Tgc	p.S562C		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	562						integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				GGGTGCTGGCTGAAGCCCCCG	0.597000													39	94					0	0	1	0	0
SPECC1	92521	broad.mit.edu	37	17	20209394	20209394	+	Splice_Site	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:20209394T>A	ENST00000395530.2	+	12	3081	c.2874_splice	c.e12+1	p.L958_splice	SPECC1_ENST00000395527.4_Splice_Site_p.L1039_splice|SPECC1_ENST00000536879.1_Splice_Site_p.L379_splice|AC004702.2_ENST00000580225.1_lincRNA|SPECC1_ENST00000261503.5_Splice_Site_p.L1039_splice	NM_001033555.2	NP_001028727.1	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	1039						nucleus				breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		AAACCCAGCCTGGTACGTATC	0.358000													44	60					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36742829	36742829	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:36742829G>T	ENST00000244751.2	-	10	1270	c.646C>A	c.(646-648)Cac>Aac	p.H216N		NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	216	C2 2.									central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						TCGGTCTTGTGGCAAATGGTG	0.532000													10	29					0.00829132	0.00844165	1	1	0
BHLHE22	27319	broad.mit.edu	37	8	65494139	65494139	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:65494139G>C	ENST00000321870.1	+	1	1326	c.792G>C	c.(790-792)gaG>gaC	p.E264D	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	264	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						CGCTGGACGAGCTGCGCGCGG	0.627000													8	31					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9014624	9014624	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:9014624C>A	ENST00000397910.4	-	31	38554	c.38351G>T	c.(38350-38352)aGg>aTg	p.R12784M		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12786	SEA 5.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGCTGCTCCCTGTCCACTCC	0.577000													81	117					2.33925e-33	3.39493e-33	1	1	0
PAPPA2	60676	broad.mit.edu	37	1	176526072	176526072	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:176526072G>C	ENST00000367662.3	+	2	1778	c.614G>C	c.(613-615)cGg>cCg	p.R205P	PAPPA2_ENST00000367661.3_Missense_Mutation_p.R205P	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	205					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.R205P(4)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TGGAAGAGGCGGGCGGAAGAT	0.562000													40	143					0	0	1	0	0
AKT3	10000	broad.mit.edu	37	1	243801040	243801040	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:243801040A>T	ENST00000366539.1	-	6	634	c.434T>A	c.(433-435)aTg>aAg	p.M145K	AKT3_ENST00000263826.5_Missense_Mutation_p.M145K|AKT3_ENST00000366540.1_Missense_Mutation_p.M145K|AKT3_ENST00000336199.5_Missense_Mutation_p.M145K			Q9Y243	AKT3_HUMAN	v-akt murine thymoma viral oncogene homolog 3	145					signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|skin(3)|stomach(1)	26	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			AAAATCATTCATTGTCTGAAA	0.279000													20	15					0	0	1	0	0
GPR31	2853	broad.mit.edu	37	6	167571176	167571176	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:167571176C>A	ENST00000366834.1	-	1	641	c.144G>T	c.(142-144)ccG>ccT	p.P48P		NM_005299.2	NP_005290.2	O00270	GPR31_HUMAN	G protein-coupled receptor 31	48						integral to plasma membrane	G-protein coupled receptor activity	p.P48P(1)		NS(1)|endometrium(4)|large_intestine(4)|lung(7)|prostate(1)	17		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		AGACAGCGTACGGCTTCCACA	0.652000													20	57					5.49717e-05	5.87545e-05	1	1	0
ACSS3	79611	broad.mit.edu	37	12	81568637	81568637	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:81568637T>G	ENST00000548058.1	+	8	2079	c.1169T>G	c.(1168-1170)tTg>tGg	p.L390W	ACSS3_ENST00000261206.3_Missense_Mutation_p.L389W|ACSS3_ENST00000548324.1_Missense_Mutation_p.L72W			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	390						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						GTAGCTGCCTTGTTTACAGCA	0.507000													10	40					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34276392	34276392	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:34276392G>A	ENST00000373381.4	-	10	1574	c.1398C>T	c.(1396-1398)gaC>gaT	p.D466D	CSMD2_ENST00000338325.1_Silent_p.D23D	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	426	CUB 3.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTGCATTGTTGTCATACTGAA	0.572000													35	111					0	0	1	0	0
TMEM175	84286	broad.mit.edu	37	4	951745	951745	+	Missense_Mutation	SNP	G	G	A	rs143946130		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:951745G>A	ENST00000264771.4	+	11	1161	c.976G>A	c.(976-978)Gcc>Acc	p.A326T	TMEM175_ENST00000515740.1_Missense_Mutation_p.A210T|TMEM175_ENST00000508204.1_Missense_Mutation_p.A244T	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	326						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GCTGTGGTTCGCCCACCACTC	0.677000													8	48					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55146110	55146110	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:55146110G>C	ENST00000396331.1	+	11	1736	c.1379G>C	c.(1378-1380)gGg>gCg	p.G460A	LILRB1_ENST00000396315.1_Missense_Mutation_p.G461A|LILRB1_ENST00000448689.1_Missense_Mutation_p.G460A|LILRB1_ENST00000396332.4_Missense_Mutation_p.G460A|LILRB1_ENST00000427581.2_Missense_Mutation_p.G510A|LILRB1_ENST00000418536.2_Missense_Mutation_p.G444A|LILRB1_ENST00000396321.2_Missense_Mutation_p.G460A|LILRB1_ENST00000396317.1_Missense_Mutation_p.G444A|LILRB1_ENST00000324602.7_Missense_Mutation_p.G461A|LILRB1_ENST00000396327.3_Missense_Mutation_p.G461A|LILRB1_ENST00000462628.1_3'UTR|LILRB1_ENST00000434867.2_Missense_Mutation_p.G460A	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	460					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		AGGCACCTGGGGGTTGTGATC	0.572000										HNSCC(37;0.09)			17	34					0	0	1	0	0
SLC12A1	6557	broad.mit.edu	37	15	48543856	48543856	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:48543856T>C	ENST00000396577.3	+	15	2046	c.1831T>C	c.(1831-1833)Ttt>Ctt	p.F611L	SLC12A1_ENST00000380993.3_Missense_Mutation_p.F611L|SLC12A1_ENST00000558405.1_Missense_Mutation_p.F611L	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	611					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GGTATCTCTTTTTGGAGCTGT	0.418000													22	38					0	0	1	0	0
GANC	2595	broad.mit.edu	37	15	42632010	42632010	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:42632010A>C	ENST00000318010.8	+	17	2227	c.1987A>C	c.(1987-1989)Acc>Ccc	p.T663P		NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	663					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GGAGGAACACACCCGACTCAT	0.572000													6	81					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155271092	155271092	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:155271092G>A	ENST00000342741.4	-	1	133	c.95C>T	c.(94-96)cCa>cTa	p.P32L		NM_000298.5	NP_000289.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	32					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	CTTACCTCCTGGAGCCCCAAT	0.502000													38	35					0	0	1	0	0
TRDN	10345	broad.mit.edu	37	6	123545262	123545262	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:123545262C>T	ENST00000334268.4	-	38	2283	c.1966G>A	c.(1966-1968)Gta>Ata	p.V656I	TRDN_ENST00000398178.3_Missense_Mutation_p.V664I			Q13061	TRDN_HUMAN	triadin	664					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		GAAGCTGGTACATCTTCAACA	0.323000													16	39					0	0	1	0	0
SERTAD2	9792	broad.mit.edu	37	2	64863928	64863928	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:64863928G>A	ENST00000313349.3	-	2	375	c.78C>T	c.(76-78)gaC>gaT	p.D26D	SERTAD2_ENST00000476805.1_5'UTR	NM_014755.2	NP_055570.1	Q14140	SRTD2_HUMAN	SERTA domain containing 2	26					negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus				breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|skin(1)	12						TGGATGGACCGTCACAGGGAG	0.493000													66	148					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55874936	55874936	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:55874936T>C	ENST00000388975.3	-	8	949	c.833A>G	c.(832-834)cAc>cGc	p.H278R		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	278					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GAAGTCACAGTGATTTTCATT	0.318000													25	22					0	0	1	0	0
LRP12	29967	broad.mit.edu	37	8	105503749	105503749	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:105503749G>T	ENST00000276654.5	-	7	1840	c.1732C>A	c.(1732-1734)Ctg>Atg	p.L578M	LRP12_ENST00000518375.1_5'UTR|LRP12_ENST00000424843.2_Missense_Mutation_p.L559M	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	578					endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GCTAGCCTCAGATTTTCCAAA	0.348000													44	33					5.48756e-27	7.73344e-27	1	1	0
MSTO1	55154	broad.mit.edu	37	1	155582079	155582079	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:155582079G>T	ENST00000245564.2	+	8	809	c.785G>T	c.(784-786)gGc>gTc	p.G262V	MSTO1_ENST00000538143.1_Intron|MSTO1_ENST00000483734.1_3'UTR|MSTO1_ENST00000452804.2_Intron|MSTO1_ENST00000368341.4_Missense_Mutation_p.G227V	NM_001256532.1|NM_001256533.1|NM_018116.3	NP_001243461.1|NP_001243462.1|NP_060586.2	Q9BUK6	MSTO1_HUMAN	misato 1, mitochondrial distribution and morphology regulator	262					mitochondrion distribution|protein polymerization	mitochondrial outer membrane|protein complex				breast(2)|endometrium(1)|lung(3)|skin(1)	7	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)					ATAACCTGGGGCCTGCTACCT	0.552000													20	52					1.9806e-07	2.20738e-07	1	1	0
FAM65A	79567	broad.mit.edu	37	16	67575783	67575783	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:67575783G>T	ENST00000540839.3	+	14	1374	c.1154G>T	c.(1153-1155)cGg>cTg	p.R385L	FAM65A_ENST00000379312.3_Missense_Mutation_p.R369L|FAM65A_ENST00000042381.4_Missense_Mutation_p.R365L|FAM65A_ENST00000422602.2_Missense_Mutation_p.R385L|FAM65A_ENST00000428437.2_Missense_Mutation_p.R379L			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	369						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		ATGCTGCGACGGCAGGAGGAG	0.587000													30	33					1.7881e-09	2.05561e-09	1	1	0
ST5	6764	broad.mit.edu	37	11	8739408	8739408	+	Silent	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:8739408A>G	ENST00000534127.1	-	8	1894	c.1509T>C	c.(1507-1509)gaT>gaC	p.D503D	ST5_ENST00000526099.1_Silent_p.D16D|ST5_ENST00000526757.1_Silent_p.D83D|ST5_ENST00000530438.1_Silent_p.D83D|ST5_ENST00000357665.1_Silent_p.D503D|ST5_ENST00000313726.6_Silent_p.D503D|ST5_ENST00000530991.1_5'UTR	NM_005418.3	NP_005409.3	P78524	ST5_HUMAN	suppression of tumorigenicity 5	503					positive regulation of ERK1 and ERK2 cascade		protein binding			NS(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(13)|liver(1)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	39				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		TTAAGTCCACATCCTCATATG	0.502000													24	17					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214556821	214556821	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:214556821G>A	ENST00000366956.5	-	13	2571	c.2377C>T	c.(2377-2379)Cgg>Tgg	p.R793W	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	793					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GGGTCAGTCCGAGACATGCTG	0.632000													20	97					0	0	1	0	0
CCL1	6346	broad.mit.edu	37	17	32688835	32688835	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:32688835T>C	ENST00000225842.3	-	2	226	c.157A>G	c.(157-159)Acc>Gcc	p.T53A		NM_002981.1	NP_002972.1	P22362	CCL1_HUMAN	chemokine (C-C motif) ligand 1	53					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity						Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		ATGGAGCTGGTATTTCTGTAA	0.493000											OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	93	136					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71606169	71606169	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:71606169A>G	ENST00000265382.3	+	15	1921	c.1616A>G	c.(1615-1617)tAt>tGt	p.539_539insC	PIP5K1B_ENST00000541509.1_Intron	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	0						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		CTTGACGTCTATTTAGTAAGT	0.438000													9	35					0	0	1	0	0
LSM1	27257	broad.mit.edu	37	8	38021207	38021207	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:38021207T>C	ENST00000311351.4	-	4	778	c.383A>G	c.(382-384)gAt>gGt	p.D128G	RP11-90P5.2_ENST00000520598.1_RNA|LSM1_ENST00000520755.1_3'UTR|LSM1_ENST00000522515.1_5'UTR	NM_014462.2	NP_055277.1	O15116	LSM1_HUMAN	LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)	128					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|mRNA processing|RNA splicing, via transesterification reactions	cytosol|nucleus|ribonucleoprotein complex	protein binding|RNA binding			kidney(2)|large_intestine(3)|lung(2)	7	Colorectal(12;0.000442)					ATCAAGAGTATCTGCTCGAGG	0.498000													15	19					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39805044	39805044	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:39805044C>A	ENST00000248668.4	-	1	932	c.933G>T	c.(931-933)gtG>gtT	p.V311V		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	311	Ig-like.					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGCCTTCCACCACCAGGGCCC	0.706000													7	12					0.00198382	0.00204836	1	1	0
GLDC	2731	broad.mit.edu	37	9	6587274	6587274	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:6587274A>G	ENST00000321612.6	-	15	1867	c.1717T>C	c.(1717-1719)Tgg>Cgg	p.W573R		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	573					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	AATTCTTTCCATGTGATAGGC	0.353000													40	16					0	0	1	0	0
AVPR1A	552	broad.mit.edu	37	12	63544027	63544027	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:63544027A>G	ENST00000299178.2	-	1	695	c.590T>C	c.(589-591)gTc>gCc	p.V197A		NM_000706.4	NP_000697.1	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	197					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|prostate(2)|skin(1)	26			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	GGCCTTGGTGACATTGTTCAC	0.652000													41	98					0	0	1	0	0
CLINT1	9685	broad.mit.edu	37	5	157218920	157218920	+	Nonsense_Mutation	SNP	C	C	A	rs1803856		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:157218920C>A	ENST00000523094.1	-	10	1322	c.1117G>T	c.(1117-1119)Gag>Tag	p.E373*	CLINT1_ENST00000411809.2_Nonsense_Mutation_p.E391*|CLINT1_ENST00000296951.5_Nonsense_Mutation_p.E373*|CLINT1_ENST00000530742.1_Nonsense_Mutation_p.E373*|CLINT1_ENST00000523908.1_Nonsense_Mutation_p.E391*	NM_001195555.1|NM_001195556.1	NP_001182484.1|NP_001182485.1	Q14677	EPN4_HUMAN	clathrin interactor 1	391					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|urinary_tract(1)	21	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCAAAGAACTCGCCACTGGAA	0.512000													35	25					1.04352e-10	1.23865e-10	1	1	0
ZMAT4	79698	broad.mit.edu	37	8	40532344	40532344	+	Silent	SNP	G	G	T	rs141980582	byFrequency	TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:40532344G>T	ENST00000297737.6	-	5	602	c.456C>A	c.(454-456)gcC>gcA	p.A152A	ZMAT4_ENST00000315769.7_Intron	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	152						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			TATTAAACCAGGCTGCACAGA	0.507000													64	207					7.75977e-34	1.13293e-33	1	1	0
MUC17	140453	broad.mit.edu	37	7	100681213	100681213	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:100681213G>T	ENST00000306151.4	+	3	6580	c.6516G>T	c.(6514-6516)gtG>gtT	p.V2172V		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2172	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GCACCACAGTGGTGGCCAGTT	0.468000													217	285					3.89567e-114	5.91235e-114	1	1	0
SERPINB6	5269	broad.mit.edu	37	6	2949295	2949295	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:2949295C>A	ENST00000380520.1	-	5	2576	c.582G>T	c.(580-582)gaG>gaT	p.E194D	SERPINB6_ENST00000335686.5_Missense_Mutation_p.E194D|SERPINB6_ENST00000380529.1_Missense_Mutation_p.E194D|SERPINB6_ENST00000380539.1_Missense_Mutation_p.E194D|SERPINB6_ENST00000380524.1_Missense_Mutation_p.E194D|SERPINB6_ENST00000380546.3_Missense_Mutation_p.E194D			P35237	SPB6_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 6	194					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|stomach(1)|upper_aerodigestive_tract(2)	17	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	GCACAGGTTTCTCCTCATTCT	0.408000													13	22					0.00136819	0.0014248	1	1	0
SYNE1	23345	broad.mit.edu	37	6	152638075	152638075	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:152638075A>T	ENST00000367255.5	-	87	17220	c.16619T>A	c.(16618-16620)tTg>tAg	p.L5540*	SYNE1_ENST00000356820.4_Nonsense_Mutation_p.L64*|SYNE1_ENST00000448038.1_Nonsense_Mutation_p.L5469*|SYNE1_ENST00000341594.5_Nonsense_Mutation_p.L5152*|SYNE1_ENST00000265368.4_Nonsense_Mutation_p.L5540*|SYNE1_ENST00000423061.1_Nonsense_Mutation_p.L5469*	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5540					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AATCCACTTCAAAATTAATTC	0.353000										HNSCC(10;0.0054)			17	27					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62393502	62393502	+	Splice_Site	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:62393502G>T	ENST00000371158.2	+	27	3784		c.e27+1		INADL_ENST00000316485.6_Splice_Site	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)						intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TTTACCGACCGTGAGTGCCTT	0.383000													20	41					8.10497e-08	9.08853e-08	1	1	0
HLX	3142	broad.mit.edu	37	1	221053746	221053746	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:221053746T>C	ENST00000366903.6	+	1	2048	c.547T>C	c.(547-549)Tct>Cct	p.S183P		NM_021958.3	NP_068777.1	Q14774	HLX_HUMAN	H2.0-like homeobox	183					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(9)|lung(11)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(131;0.00914)		CCGCATTTTATCTGCAGAATT	0.602000													76	36					0	0	1	0	0
DPPA3P2	400206	broad.mit.edu	37	14	36841171	36841171	+	RNA	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:36841171A>G	ENST00000557188.1	+	0	802																											CTATGCTAGTATAGACTATAC	0.323000													6	27					0	0	1	0	0
CREB3L3	84699	broad.mit.edu	37	19	4154951	4154951	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:4154951T>C	ENST00000078445.2	+	2	230	c.83T>C	c.(82-84)cTc>cCc	p.L28P	CREB3L3_ENST00000595923.1_Missense_Mutation_p.L28P|CREB3L3_ENST00000602257.1_Missense_Mutation_p.L28P|CREB3L3_ENST00000602147.1_Missense_Mutation_p.L28P|CREB3L3_ENST00000252587.3_Missense_Mutation_p.L19P	NM_001271995.1|NM_001271996.1|NM_032607.1	NP_001258924.1|NP_001258925.1|NP_115996.1	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like 3	28					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|urinary_tract(3)	24				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCTGGATCTCCTGTTTGAC	0.627000													56	115					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48703453	48703453	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:48703453G>C	ENST00000316623.5	-	66	8805	c.8350C>G	c.(8350-8352)Ctt>Gtt	p.L2784V	FBN1_ENST00000561429.1_5'UTR	NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2784					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding	p.L2784I(1)		NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGAGTTGTAAGAGCTGGAAGG	0.418000													57	88					0	0	1	0	0
ST3GAL5	8869	broad.mit.edu	37	2	86071632	86071632	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:86071632T>C	ENST00000377332.3	-	6	1003	c.895A>G	c.(895-897)Atc>Gtc	p.I299V	ST3GAL5_ENST00000393808.3_Missense_Mutation_p.I276V|ST3GAL5_ENST00000393805.1_Missense_Mutation_p.I271V	NM_003896.3	NP_003887.3	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	299					ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15						TGCAGTGGGATTTTTTCTGCC	0.458000													14	96					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86773076	86773076	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:86773076C>T	ENST00000373119.4	+	1	325	c.180C>T	c.(178-180)aaC>aaT	p.N60N	KLHL4_ENST00000373114.4_Silent_p.N60N	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	60						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						GGGACAGAAACGGACTGAAGA	0.547000													27	12					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238287556	238287556	+	Silent	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:238287556A>G	ENST00000295550.4	-	6	2672	c.2220T>C	c.(2218-2220)cgT>cgC	p.R740R	COL6A3_ENST00000392004.3_Silent_p.R534R|COL6A3_ENST00000392003.2_Silent_p.R333R|COL6A3_ENST00000409809.1_Silent_p.R534R|COL6A3_ENST00000347401.3_Silent_p.R539R|COL6A3_ENST00000353578.4_Silent_p.R534R|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000346358.4_Intron	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	740	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCACGTGTTCACGGATCCTGC	0.607000													25	38					0	0	1	0	0
GNA14	9630	broad.mit.edu	37	9	80046236	80046236	+	Splice_Site	SNP	C	C	A	rs140029377		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:80046236C>A	ENST00000341700.6	-	4	1107		c.e4+1		GNA14_ENST00000464095.1_Splice_Site	NM_004297.3	NP_004288.1	O95837	GNA14_HUMAN	guanine nucleotide binding protein (G protein), alpha 14						activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	24						GACAGACTTACCGAAAGATGA	0.478000													45	59					1.61004e-24	2.25591e-24	1	1	0
GRM7	2917	broad.mit.edu	37	3	7348258	7348258	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:7348258T>G	ENST00000486284.1	+	4	1226	c.952T>G	c.(952-954)Tcc>Gcc	p.S318A	GRM7_ENST00000389336.4_Missense_Mutation_p.S318A|GRM7_ENST00000357716.4_Missense_Mutation_p.S318A|GRM7_ENST00000403881.1_Missense_Mutation_p.S318A|GRM7_ENST00000402647.2_Missense_Mutation_p.S318A	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	318					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CAGCTGGGGATCCAAAATAAA	0.498000													26	33					0	0	1	0	0
CRHR1	1394	broad.mit.edu	37	17	43893833	43893833	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:43893833G>A	ENST00000314537.5	+	3	351	c.126G>A	c.(124-126)ctG>ctA	p.L42L	CRHR1_ENST00000577353.1_Silent_p.L42L|CRHR1_ENST00000398285.3_Silent_p.L42L|CRHR1_ENST00000293493.7_5'UTR|CRHR1_ENST00000352855.5_Intron|RP11-105N13.4_ENST00000587305.1_RNA|CRHR1_ENST00000339069.5_5'UTR	NM_001145147.1|NM_001145148.1|NM_004382.4	NP_001138619.1|NP_001138620.1|NP_004373.2	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	42					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		CCCCAGGACTGCAGTGCAACG	0.642000													25	29					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100146	168100146	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:168100146G>T	ENST00000409195.1	+	9	2333	c.2244G>T	c.(2242-2244)tcG>tcT	p.S748S	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Silent_p.S748S|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409273.1_Silent_p.S526S|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	573					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAGATGGTTCGGGCCAAATGC	0.383000													24	61					1.55469e-16	2.03028e-16	1	1	0
SYNE2	23224	broad.mit.edu	37	14	64493314	64493314	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:64493314G>T	ENST00000358025.3	+	42	6500	c.6270G>T	c.(6268-6270)aaG>aaT	p.K2090N	SYNE2_ENST00000554584.1_Missense_Mutation_p.K2090N|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Missense_Mutation_p.K2090N	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2090					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTTTGCTGAAGCCTGAAGGGG	0.418000													16	28					1.5739e-10	1.86215e-10	1	1	0
WDR72	256764	broad.mit.edu	37	15	53992035	53992035	+	Silent	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:53992035A>C	ENST00000396328.1	-	13	1916	c.1677T>G	c.(1675-1677)ccT>ccG	p.P559P	WDR72_ENST00000360509.5_Silent_p.P559P|WDR72_ENST00000559418.1_Silent_p.P569P|WDR72_ENST00000557913.1_Silent_p.P556P	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	559										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TCATCCTCACAGGAAAAAGGT	0.448000													54	158					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9514922	9514922	+	Silent	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:9514922A>T	ENST00000402466.1	+	21	3672	c.2904A>T	c.(2902-2904)gtA>gtT	p.V968V	SETD5_ENST00000402198.1_Silent_p.V1066V|SETD5_ENST00000302463.6_Silent_p.V968V|SETD5_ENST00000407969.1_Silent_p.V1085V|SETD5_ENST00000406341.1_Silent_p.V1066V			Q9C0A6	SETD5_HUMAN	SET domain containing 5	1066										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		CTTTCTAGGTATCCCTGCTGG	0.448000													18	15					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47205965	47205965	+	Translation_Start_Site	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:47205965G>A	ENST00000263737.6	+	0	682				TTC7A_ENST00000394850.2_Missense_Mutation_p.G228D|TTC7A_ENST00000409245.1_Missense_Mutation_p.G194D|TTC7A_ENST00000461601.1_3'UTR|TTC7A_ENST00000319190.5_Missense_Mutation_p.G228D			Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A								binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			CATCTGAAAGGCTGTCACCCG	0.517000													18	60					0	0	1	0	0
ZNF566	84924	broad.mit.edu	37	19	36939917	36939917	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:36939917C>T	ENST00000454319.1	-	5	1356	c.1222G>A	c.(1222-1224)Gac>Aac	p.D408N	ZNF566_ENST00000493391.1_Missense_Mutation_p.D303N|ZNF566_ENST00000434377.2_Missense_Mutation_p.D407N|ZNF566_ENST00000424129.2_Missense_Mutation_p.D407N|ZNF566_ENST00000392170.2_Missense_Mutation_p.D408N	NM_001145343.1|NM_001145344.1|NM_001145345.1	NP_001138815.1|NP_001138816.1|NP_001138817.1	Q969W8	ZN566_HUMAN	zinc finger protein 566	407					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24	Esophageal squamous(110;0.162)					AGTTGTGGGTCATAATTAAAG	0.333000													6	23					0	0	1	0	0
SESTD1	91404	broad.mit.edu	37	2	180041225	180041225	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:180041225C>A	ENST00000428443.3	-	4	521	c.205G>T	c.(205-207)Ggc>Tgc	p.G69C	SESTD1_ENST00000486468.1_5'UTR	NM_178123.4	NP_835224.3	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	69	CRAL-TRIO.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(3)	30			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			GATTTTCTGCCATCCACAATC	0.348000													10	35					2.17888e-05	2.34599e-05	1	1	0
FAT4	79633	broad.mit.edu	37	4	126336448	126336448	+	Silent	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:126336448A>G	ENST00000394329.3	+	5	6343	c.6330A>G	c.(6328-6330)ggA>ggG	p.G2110G	FAT4_ENST00000335110.5_Silent_p.G408G	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2110	Cadherin 20.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GGCTCACTGGAGAACTGGACA	0.438000													63	115					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85905587	85905587	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:85905587T>A	ENST00000304195.3	-	13	1332	c.1126A>T	c.(1126-1128)Aac>Tac	p.N376Y	FRMD3_ENST00000376434.1_Missense_Mutation_p.N182Y|FRMD3_ENST00000376438.1_Missense_Mutation_p.N376Y	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	376						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						GGTTCCATGTTAATGATGAGC	0.498000													47	48					0	0	1	0	0
NIPSNAP1	8508	broad.mit.edu	37	22	29966184	29966184	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr22:29966184T>A	ENST00000216121.7	-	3	493	c.239A>T	c.(238-240)aAg>aTg	p.K80M		NM_001202502.1|NM_003634.3	NP_001189431.1|NP_003625.2	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1 (C. elegans)	80								p.?(1)		large_intestine(2)|lung(2)|skin(1)	5						GTATTCAGGCTTTACATTGTG	0.532000													11	59					0	0	1	0	0
CASP2	835	broad.mit.edu	37	7	142997027	142997027	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:142997027G>C	ENST00000310447.5	+	7	1000	c.759G>C	c.(757-759)gaG>gaC	p.E253D	CASP2_ENST00000493642.1_3'UTR	NM_032982.3|NM_032983.3	NP_116764.2|NP_116765.2	P42575	CASP2_HUMAN	caspase 2, apoptosis-related cysteine peptidase	253					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)	21	Melanoma(164;0.059)					AAATGCAAGAGAAACTGCAGA	0.463000											OREG0018400	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	64					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102477335	102477335	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:102477335A>C	ENST00000260228.2	-	6	896	c.884T>G	c.(883-885)cTc>cGc	p.L295R	MMP20_ENST00000544938.1_5'UTR	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	295					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		GGAGTCACAGAGGTCAGGGAT	0.542000													33	58					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43262174	43262174	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:43262174G>T	ENST00000404209.4	-	3	785	c.689C>A	c.(688-690)cCa>cAa	p.P230Q	PSG8_ENST00000600709.1_5'UTR|PSG8_ENST00000306511.4_Missense_Mutation_p.P230Q|PSG8_ENST00000401467.2_Intron|PSG8_ENST00000406636.3_Missense_Mutation_p.P108Q	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	230	Ig-like C2-type 1.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				CAGGGTGAATGGGTCACTGCG	0.527000													183	496					8.39465e-107	1.27139e-106	1	1	0
NPAS4	266743	broad.mit.edu	37	11	66192145	66192145	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:66192145G>A	ENST00000311034.2	+	7	1960	c.1784G>A	c.(1783-1785)cGg>cAg	p.R595Q		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	595					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						GCCCAGCTCCGGGGCCCCCTC	0.592000													88	126					0	0	1	0	0
SLC13A3	64849	broad.mit.edu	37	20	45188830	45188830	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:45188830G>C	ENST00000279027.4	-	13	1658	c.1640C>G	c.(1639-1641)aCa>aGa	p.T547R	SLC13A3_ENST00000472148.1_Missense_Mutation_p.T465R|SLC13A3_ENST00000495082.1_Missense_Mutation_p.T500R|SLC13A3_ENST00000413164.2_Missense_Mutation_p.T497R|SLC13A3_ENST00000396360.1_Missense_Mutation_p.T465R|SLC13A3_ENST00000435032.1_Missense_Mutation_p.T132R|SLC13A3_ENST00000290317.5_Missense_Mutation_p.T500R	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	547						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	CAGGAGGCCTGTCCGCACCTG	0.562000													46	101					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76957857	76957857	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:76957857C>G	ENST00000380887.2	+	6	927	c.855C>G	c.(853-855)atC>atG	p.I285M	ESRRB_ENST00000556177.1_Missense_Mutation_p.I285M|ESRRB_ENST00000261532.7_Missense_Mutation_p.I285M|ESRRB_ENST00000509242.1_Missense_Mutation_p.I285M			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	285						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		AAATCCTCATCCTGGGCATCG	0.622000													7	11					0	0	1	0	0
BBS4	585	broad.mit.edu	37	15	73023941	73023941	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:73023941T>C	ENST00000268057.4	+	12	951	c.910T>C	c.(910-912)Tgg>Cgg	p.W304R	BBS4_ENST00000395205.2_Missense_Mutation_p.W312R|BBS4_ENST00000539603.1_Missense_Mutation_p.W292R|BBS4_ENST00000542334.1_Missense_Mutation_p.W132R	NM_033028.4	NP_149017.2	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	304	Interaction with PCM1.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity			autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(1)	19						ACCCTTTGATTGGAAGATTCT	0.468000									Bardet-Biedl syndrome				20	110					0	0	1	0	0
ERMAP	114625	broad.mit.edu	37	1	43308322	43308322	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:43308322C>G	ENST00000328249.3	+	9	1615	c.577C>G	c.(577-579)Cta>Gta	p.L193V	ERMAP_ENST00000372514.3_Missense_Mutation_p.L283V|ERMAP_ENST00000372517.2_Missense_Mutation_p.L283V|ERMAP_ENST00000487556.1_3'UTR|RP11-342M1.2_ENST00000416809.2_RNA|RP11-342M1.3_ENST00000425076.1_RNA|RP11-342M1.3_ENST00000444563.1_RNA|RP11-342M1.4_ENST00000414798.1_RNA			Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein (Scianna blood group)	283			Missing (in Sc-3 allele).			integral to membrane|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TGTCAGCATCCTAGGCTCTGA	0.498000													72	74					0	0	1	0	0
EIF3E	3646	broad.mit.edu	37	8	109260897	109260897	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:109260897T>G	ENST00000220849.5	-	1	97	c.35A>C	c.(34-36)cAc>cCc	p.H12P	EIF3E_ENST00000519030.1_5'UTR	NM_001568.2	NP_001559.1	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3, subunit E	12	Sufficient for interaction with EPAS1.|Sufficient for interaction with TRIM27.				negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding		EIF3E/RSPO2(6)	NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			ATCCAAAAAGTGCGCGATGCG	0.517000													62	65					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66871463	66871463	+	Silent	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:66871463T>A	ENST00000269080.2	-	35	4586	c.4449A>T	c.(4447-4449)gcA>gcT	p.A1483A	ABCA8_ENST00000430352.2_Silent_p.A1523A|ABCA8_ENST00000586539.1_Silent_p.A1523A	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1483						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GCTCCACTTGTGCCAGGTTCT	0.488000													33	67					0	0	1	0	0
OR52E6	390078	broad.mit.edu	37	11	5862348	5862348	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:5862348G>A	ENST00000329322.5	-	1	779	c.780C>T	c.(778-780)ttC>ttT	p.F260F	TRIM5_ENST00000380027.1_Intron|OR52E6_ENST00000379946.2_Silent_p.F264F	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGTGTGTAAAGAAAGAGAAAA	0.443000													23	20					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21689289	21689289	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:21689289T>A	ENST00000398485.2	+	3	1064	c.1010T>A	c.(1009-1011)gTg>gAg	p.V337E	PAX1_ENST00000460221.1_3'UTR|PAX1_ENST00000444366.2_Missense_Mutation_p.V313E	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	337					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						ACCCCCGCAGTGAATGGGCTA	0.602000													23	60					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141751612	141751612	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:141751612C>A	ENST00000389484.3	-	16	3567	c.2596G>T	c.(2596-2598)Ggc>Tgc	p.G866C		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	866	LDL-receptor class A 3.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCATCGTCGCCATCACATTTC	0.433000										TSP Lung(27;0.18)			25	73					3.6726e-16	4.75355e-16	1	1	0
GBP5	115362	broad.mit.edu	37	1	89732735	89732735	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:89732735A>G	ENST00000343435.5	-	6	1066	c.530T>C	c.(529-531)gTg>gCg	p.V177A	GBP5_ENST00000370459.3_Missense_Mutation_p.V177A|RP4-620F22.2_ENST00000437128.1_RNA	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	177						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		CAGAGTCCACACTAAGTCTGG	0.483000													6	126					0	0	1	0	0
TRIB2	28951	broad.mit.edu	37	2	12880894	12880894	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:12880894G>T	ENST00000155926.4	+	3	2425	c.1006G>T	c.(1006-1008)Gag>Tag	p.E336*	TRIB2_ENST00000381465.2_Nonsense_Mutation_p.E200*	NM_021643.3	NP_067675.1	Q92519	TRIB2_HUMAN	tribbles pseudokinase 2	336					negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(5)|prostate(1)|skin(1)|stomach(1)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CAACATGGAAGAGAACTTGGA	0.522000													36	62					6.97489e-18	9.19074e-18	1	1	0
WDR17	116966	broad.mit.edu	37	4	177098223	177098223	+	Missense_Mutation	SNP	G	G	T	rs148628975	byFrequency	TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:177098223G>T	ENST00000393643.2	+	28	3761	c.3509G>T	c.(3508-3510)cGt>cTt	p.R1170L	WDR17_ENST00000508596.1_Missense_Mutation_p.R1155L|WDR17_ENST00000507824.2_Missense_Mutation_p.R1169L|WDR17_ENST00000280190.4_Missense_Mutation_p.R1194L	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	1194										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		CTATTAAAACGTCGGGAGGTG	0.353000													14	16					2.62699e-14	3.28937e-14	1	1	0
TTN	7273	broad.mit.edu	37	2	179434884	179434884	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:179434884C>A	ENST00000589042.1	-	326	76199	c.75975G>T	c.(75973-75975)tgG>tgT	p.W25325C	TTN_ENST00000591111.1_Missense_Mutation_p.W23684C|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.W16260C|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.W22757C|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.W16452C|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.W16385C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	23684	Ig-like 124.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGTCTTTCCCATACAACAA	0.428000													40	45					4.00102e-26	5.61681e-26	1	1	0
RNF10	9921	broad.mit.edu	37	12	120972711	120972711	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:120972711G>T	ENST00000325954.4	+	1	558	c.97G>T	c.(97-99)Ggg>Tgg	p.G33W	RNF10_ENST00000413266.2_Missense_Mutation_p.G33W	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	33	Ser-rich.				negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGCAGCAAAGGGCAACAGCC	0.711000													9	23					0.0692343	0.0698081	1	1	0
NYAP2	57624	broad.mit.edu	37	2	226447444	226447444	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:226447444C>A	ENST00000272907.6	+	4	1724	c.1311C>A	c.(1309-1311)ccC>ccA	p.P437P	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	437	Pro-rich.																CCACCTCTCCCTCCCCCGTCA	0.642000													27	24					1.42536e-11	1.71137e-11	1	1	0
IGSF5	150084	broad.mit.edu	37	21	41142994	41142994	+	Silent	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr21:41142994T>C	ENST00000380588.4	+	4	673	c.570T>C	c.(568-570)gtT>gtC	p.V190V	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	190	Ig-like V-type 2.					integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				ATTATTTTGTTCCGGAGCCCA	0.542000													33	46					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193171890	193171890	+	Splice_Site	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:193171890C>A	ENST00000342695.4	-	17	2349	c.2027_splice	c.e17+1	p.R676_splice	ATP13A4_ENST00000392443.3_Splice_Site_p.R657_splice	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	676					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CCCCATTTACCTCGTCAAGGT	0.448000													36	50					3.21399e-22	4.44359e-22	1	1	0
LOC100130331	100130331	broad.mit.edu	37	1	238090561	238090561	+	RNA	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:238090561C>T	ENST00000450451.1	+	0	2067					NR_027247.2																						CCCTCTACGCCTCTGGGCGCA	0.592000													58	42					0	0	1	0	0
HIST1H3D	8351	broad.mit.edu	37	6	26197415	26197415	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:26197415C>A	ENST00000377831.5	-	2	517	c.64G>T	c.(64-66)Gcc>Tcc	p.A22S	HIST1H3D_ENST00000356476.2_Missense_Mutation_p.A22S	NM_003530.3	NP_003521.2	P68431	H31_HUMAN	histone cluster 1, H3d	22					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)	14		all_hematologic(11;0.196)				GCCTTGGTGGCCAGCTGCTTG	0.622000													53	90					9.57592e-29	1.36266e-28	1	1	0
FER1L6	654463	broad.mit.edu	37	8	125052131	125052131	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:125052131G>A	ENST00000522917.1	+	20	2679	c.2473G>A	c.(2473-2475)Gtt>Att	p.V825I	FER1L6_ENST00000399018.1_Missense_Mutation_p.V825I|RP11-959I15.4_ENST00000522005.1_RNA|FER1L6-AS1_ENST00000518567.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	825	C2 3.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AGAACAGCATGTTTTTCAGCT	0.498000													23	134					0	0	1	0	0
AFF1	4299	broad.mit.edu	37	4	88026817	88026817	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:88026817G>T	ENST00000307808.6	+	8	1720	c.1300G>T	c.(1300-1302)Gac>Tac	p.D434Y	AFF1_ENST00000544085.1_Missense_Mutation_p.D72Y|AFF1_ENST00000395146.4_Missense_Mutation_p.D441Y	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	434						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TGACAGTGAGGACAGTGACAG	0.423000													42	60					1.00776e-21	1.38282e-21	1	1	0
TTBK1	84630	broad.mit.edu	37	6	43220480	43220480	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:43220480A>T	ENST00000259750.4	+	3	195	c.112A>T	c.(112-114)Aaa>Taa	p.K38*	TTBK1_ENST00000304139.5_5'UTR	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	38	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TTCATAGCTGAAAAAGATCGG	0.587000													32	38					0	0	1	0	0
RASL10B	91608	broad.mit.edu	37	17	34068216	34068216	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:34068216G>A	ENST00000268864.3	+	4	881	c.504G>A	c.(502-504)ctG>ctA	p.L168L		NM_033315.3	NP_201572.1	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B	168	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACATCCTGCTGCTCTTCAGCG	0.662000													21	59					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66877284	66877284	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:66877284C>T	ENST00000269080.2	-	30	4032	c.3895G>A	c.(3895-3897)Gac>Aac	p.D1299N	ABCA8_ENST00000430352.2_Missense_Mutation_p.D1339N|ABCA8_ENST00000586539.1_Missense_Mutation_p.D1339N	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1299	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GGTTTTGTGTCTCCAGTTATC	0.328000													25	32					0	0	1	0	0
CCDC102B	79839	broad.mit.edu	37	18	66504330	66504330	+	Silent	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:66504330A>T	ENST00000360242.5	+	2	447	c.330A>T	c.(328-330)cgA>cgT	p.R110R	CCDC102B_ENST00000584156.1_Silent_p.R110R|CCDC102B_ENST00000577772.1_3'UTR|CCDC102B_ENST00000358653.5_Silent_p.R110R|CCDC102B_ENST00000319445.6_Silent_p.R110R	NM_024781.2	NP_079057.2	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	110										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				GTAAAGTTCGAGCTGAAAGGA	0.463000													38	30					0	0	1	0	0
OR1S1	219959	broad.mit.edu	37	11	57983029	57983029	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:57983029G>T	ENST00000309433.6	+	1	813	c.813G>T	c.(811-813)gtG>gtT	p.V271V		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				TTGTAGGCGTGTACTTTTTCC	0.483000													30	85					1.08312e-15	1.38715e-15	1	1	0
SLC4A11	83959	broad.mit.edu	37	20	3212001	3212001	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:3212001G>A	ENST00000380059.3	-	8	1153	c.1052C>T	c.(1051-1053)tCc>tTc	p.S351F	SLC4A11_ENST00000380056.3_Missense_Mutation_p.S324F|SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000539553.1_Missense_Mutation_p.S308F	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	324					cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						GGCAGGGAGGGAGACTGTGCT	0.662000													33	48					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112575275	112575275	+	Silent	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:112575275G>C	ENST00000230538.7	-	2	475	c.78C>G	c.(76-78)tcC>tcG	p.S26S	RP11-506B6.6_ENST00000588837.1_RNA|LAMA4_ENST00000431543.2_Silent_p.S26S|RP11-506B6.6_ENST00000585504.1_RNA|RP11-506B6.6_ENST00000585611.1_RNA|RP11-506B6.6_ENST00000585450.1_RNA|RP11-506B6.6_ENST00000590293.1_RNA|LAMA4_ENST00000453937.2_Silent_p.S26S|LAMA4_ENST00000368638.4_Silent_p.S26S|RP11-506B6.6_ENST00000433684.2_RNA|RP11-506B6.6_ENST00000587816.1_RNA|RP11-506B6.6_ENST00000590673.1_RNA|LAMA4_ENST00000424408.2_Silent_p.S26S|RP11-506B6.6_ENST00000590804.1_RNA|RP11-506B6.6_ENST00000590584.1_RNA|LAMA4_ENST00000389463.4_Silent_p.S26S|LAMA4_ENST00000522006.1_Silent_p.S26S	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	26					cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TGTCGTCCCCGGACGCGGCGC	0.642000													7	18					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22368694	22368694	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:22368694C>T	ENST00000332663.2	+	1	217	c.119C>T	c.(118-120)cCa>cTa	p.P40L	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTCATCCTACCAGGAAATATC	0.418000													122	850					0	0	1	0	0
RNF144A	9781	broad.mit.edu	37	2	7164499	7164499	+	Splice_Site	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:7164499G>A	ENST00000320892.6	+	7	951		c.e7-1		RNF144A_ENST00000467276.1_Splice_Site	NM_014746.3	NP_055561.2	P50876	R144A_HUMAN	ring finger protein 144A							Golgi apparatus|integral to membrane	ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)	25	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;0.226)		OV - Ovarian serous cystadenocarcinoma(76;0.195)		TTCTCCCACAGTGCTGCTTTC	0.572000													50	17					0	0	1	0	0
ZNF71	58491	broad.mit.edu	37	19	57132924	57132924	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:57132924C>T	ENST00000328070.6	+	3	503	c.269C>T	c.(268-270)cCa>cTa	p.P90L		NM_021216.4	NP_067039.1	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	90						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GTCCTGGTCCCACCACGGCTG	0.587000													13	41					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542810	14542810	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:14542810G>T	ENST00000358970.5	-	1	335	c.336C>A	c.(334-336)agC>agA	p.S112R	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	112										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TGCTCTTGCCGCTCCCCCTGC	0.592000													124	386					2.20786e-56	3.31633e-56	1	1	0
TXNDC2	84203	broad.mit.edu	37	18	9887577	9887577	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:9887577C>T	ENST00000306084.6	+	2	1300	c.1101C>T	c.(1099-1101)atC>atT	p.I367I	TXNDC2_ENST00000536353.2_3'UTR|TXNDC2_ENST00000357775.4_Silent_p.I300I	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	367	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						AAGAAGCCATCCAGCCCAAGG	0.567000													143	134					0	0	1	0	0
TRBV7-6	28592	broad.mit.edu	37	7	142139730	142139730	+	RNA	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:142139730A>G	ENST00000390374.3	-	0	85																											ACCTGTCCCTAGGAAACCCAG	0.527000													34	57					0	0	1	0	0
ADSS	159	broad.mit.edu	37	1	244587320	244587320	+	Silent	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:244587320G>C	ENST00000366535.3	-	6	832	c.516C>G	c.(514-516)tcC>tcG	p.S172S	ADSS_ENST00000462358.1_5'UTR	NM_001126.3	NP_001117.2	P30520	PURA2_HUMAN	adenylosuccinate synthase	172					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	12	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	GAGCAGCTTTGGACGAATAAA	0.418000													13	41					0	0	1	0	0
PAK6	56924	broad.mit.edu	37	15	40565639	40565639	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:40565639A>G	ENST00000455577.2	+	8	2495	c.1583A>G	c.(1582-1584)aAg>aGg	p.K528R	RP11-133K1.2_ENST00000558658.1_3'UTR|PAK6_ENST00000560346.1_Missense_Mutation_p.K528R|PAK6_ENST00000453867.1_Missense_Mutation_p.K528R|PAK6_ENST00000542403.2_Missense_Mutation_p.K528R|PAK6_ENST00000260404.4_Missense_Mutation_p.K528R|PAK6_ENST00000441369.1_Missense_Mutation_p.K528R	NM_001276718.1	NP_001263647.1	Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	528	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		CGGGACATCAAGAGTGACTCC	0.607000													18	40					0	0	1	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24942235	24942235	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:24942235C>T	ENST00000289968.6	-	19	2454	c.2385G>A	c.(2383-2385)ccG>ccA	p.P795P	ARHGAP17_ENST00000441763.2_3'UTR|ARHGAP17_ENST00000303665.5_Silent_p.P717P	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	795	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		GTCTCGGTCTCGGTAAGGTTC	0.622000													4	181					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143632975	143632975	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:143632975C>A	ENST00000408955.2	+	1	717	c.650C>A	c.(649-651)tCc>tAc	p.S217Y		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	217					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					GTTCTGTTGTCCTACATCCGG	0.527000													23	52					3.6726e-16	4.75355e-16	1	1	0
LRIT2	340745	broad.mit.edu	37	10	85984195	85984195	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:85984195G>T	ENST00000372113.4	-	2	791	c.786C>A	c.(784-786)atC>atA	p.I262I	LRIT2_ENST00000538192.1_Silent_p.I262I	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	262	Ig-like.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						CCCGGATGGTGATATTGGCAC	0.532000													34	33					1.45844e-13	1.79841e-13	1	1	0
ENTPD1	953	broad.mit.edu	37	10	97625949	97625949	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:97625949G>C	ENST00000371203.5	+	9	1515	c.928G>C	c.(928-930)Gcc>Ccc	p.A310P	ENTPD1_ENST00000539125.1_Missense_Mutation_p.A310P|ENTPD1_ENST00000453258.2_Missense_Mutation_p.A455P|ENTPD1_ENST00000371205.4_Missense_Mutation_p.A448P|RP11-429G19.3_ENST00000433113.1_RNA|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1_ENST00000371207.3_Missense_Mutation_p.A460P|ENTPD1-AS1_ENST00000451364.1_RNA|RP11-248J23.7_ENST00000491114.1_Intron|ENTPD1_ENST00000543964.1_Missense_Mutation_p.A340P	NM_001164179.1|NM_001164182.1|NM_001776.5	NP_001157651.1|NP_001157654.1|NP_001767.3	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	448					cell adhesion	integral to plasma membrane	ATP binding			cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|skin(1)	16		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		GGGCAGCGACGCCGGCTGGAC	0.502000													9	4					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155278469	155278469	+	Nonsense_Mutation	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:155278469A>C	ENST00000357232.3	-	6	701	c.702T>G	c.(700-702)taT>taG	p.Y234*	DCHS2_ENST00000339452.1_Intron	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	234	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		cctctggactatagagtccta	0.423000													19	29					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776890	5776890	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:5776890T>G	ENST00000317254.3	+	1	968	c.920T>G	c.(919-921)aTa>aGa	p.I307R	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		GACTGTGTCATAAGGATCCTT	0.418000													40	32					0	0	1	0	0
PEX5	5830	broad.mit.edu	37	12	7361164	7361164	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:7361164G>A	ENST00000266563.5	+	12	1365	c.1182G>A	c.(1180-1182)cgG>cgA	p.R394R	PEX5_ENST00000434354.2_Silent_p.R446R|PEX5_ENST00000455147.2_Silent_p.R431R|PEX5_ENST00000420616.2_Silent_p.R431R|PEX5_ENST00000412720.2_Silent_p.R452R|PEX5_ENST00000266564.3_Silent_p.R423R	NM_001131024.1	NP_001124496.1	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5	431					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)	21						ACTGGCTGCGGTACACACCAG	0.592000													48	78					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176675185	176675185	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:176675185G>T	ENST00000439151.2	+	11	4546	c.4501G>T	c.(4501-4503)Gaa>Taa	p.E1501*	NSD1_ENST00000347982.4_Nonsense_Mutation_p.E1232*|NSD1_ENST00000361032.4_Nonsense_Mutation_p.E1398*|NSD1_ENST00000354179.4_Nonsense_Mutation_p.E1232*	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1501					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TTGCAAGGGAGAACTAATGCC	0.483000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			24	15					2.44723e-14	3.06955e-14	1	1	0
MYO7A	4647	broad.mit.edu	37	11	76890166	76890166	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:76890166C>G	ENST00000409709.3	+	20	2630	c.2358C>G	c.(2356-2358)aaC>aaG	p.N786K	MYO7A_ENST00000458637.2_Missense_Mutation_p.N786K|MYO7A_ENST00000409893.1_Missense_Mutation_p.N786K|MYO7A_ENST00000409619.2_Missense_Mutation_p.N775K	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	786	IQ 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GTAGGAAGAACTACGGGCTGG	0.597000													6	9					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133760654	133760654	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:133760654G>C	ENST00000318560.5	+	11	3358	c.2977G>C	c.(2977-2979)Gca>Cca	p.A993P		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	993	F-actin-binding.|Pro-rich.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CTCGGCCCTGGCAGGGGACCA	0.672000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								45	36					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73164080	73164080	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:73164080T>A	ENST00000286657.4	-	18	2540	c.2504A>T	c.(2503-2505)aAc>aTc	p.N835I		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	835	Spacer.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ATTGTTGCTGTTGATTGTAGG	0.403000													53	86					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82834903	82834903	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:82834903C>T	ENST00000265077.3	+	8	6646	c.6081C>T	c.(6079-6081)ccC>ccT	p.P2027P	VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000343200.5_Silent_p.P1040P|VCAN_ENST00000342785.4_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2027	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAGTGCTTCCCAGTGCTGTGC	0.488000													31	19					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	94993271	94993271	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:94993271C>G	ENST00000265627.5	-	6	609	c.599G>C	c.(598-600)cGc>cCc	p.R200P	PON3_ENST00000427422.1_Missense_Mutation_p.R200P|PON1_ENST00000542556.1_Intron	NM_000940.2	NP_000931.1			paraoxonase 3											breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			ATAAGTCCAGCGAAGATCCAA	0.443000													56	175					0	0	1	0	0
ZNF700	90592	broad.mit.edu	37	19	12060409	12060409	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:12060409C>G	ENST00000482090.1	+	3	1934	c.1516C>G	c.(1516-1518)Caa>Gaa	p.Q506E	CTD-2006C1.12_ENST00000586394.1_RNA|ZNF763_ENST00000538752.1_Intron|ZNF700_ENST00000254321.5_Missense_Mutation_p.Q524E|ZNF763_ENST00000591944.1_Intron|ZNF763_ENST00000590798.1_Intron			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	524					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						CAAGTCATTTCAAACACATGA	0.373000													33	68					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906825	164906825	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:164906825C>T	ENST00000475390.1	-	2	2237	c.1794G>A	c.(1792-1794)acG>acA	p.T598T	SLITRK3_ENST00000241274.3_Silent_p.T598T			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	598	LRRCT 2.					integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CATCACGGTGCGTGAGGTTCT	0.552000										HNSCC(40;0.11)			48	42					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70460339	70460339	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:70460339G>T	ENST00000503640.1	-	5	1215	c.1160C>A	c.(1159-1161)cCt>cAt	p.P387H	UGT2A1_ENST00000512704.1_Missense_Mutation_p.P343H|UGT2A2_ENST00000457664.2_Missense_Mutation_p.P396H|UGT2A1_ENST00000502343.1_5'UTR|UGT2A1_ENST00000514019.1_Missense_Mutation_p.P553H|UGT2A1_ENST00000286604.4_Missense_Mutation_p.P387H	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	387					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						TCCCACCATAGGGACTCCGTG	0.448000													30	54					2.12542e-12	2.58162e-12	1	1	0
FLG2	388698	broad.mit.edu	37	1	152327245	152327245	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:152327245G>C	ENST00000388718.5	-	3	3089	c.3017C>G	c.(3016-3018)tCa>tGa	p.S1006*	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1006	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACTGACTTGAGCCAGAACC	0.483000													203	259					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126336742	126336742	+	Silent	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:126336742A>T	ENST00000394329.3	+	5	6637	c.6624A>T	c.(6622-6624)acA>acT	p.T2208T	FAT4_ENST00000335110.5_Silent_p.T506T	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2208	Cadherin 21.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ACTCTGTCACAGGTGCCATCA	0.458000													46	116					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108417604	108417604	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:108417604C>A	ENST00000370056.4	-	2	514	c.240G>T	c.(238-240)acG>acT	p.T80T	VAV3_ENST00000371846.4_Silent_p.T15T|VAV3_ENST00000527011.1_Silent_p.T80T	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	80	CH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CACAACAGGCCGTGAGAAATG	0.368000													11	56					3.86212e-05	4.13394e-05	1	1	0
DNMBP	23268	broad.mit.edu	37	10	101715869	101715869	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:101715869T>A	ENST00000342239.3	-	4	1453	c.1362A>T	c.(1360-1362)agA>agT	p.R454S	DNMBP-AS1_ENST00000434409.1_RNA|DNMBP_ENST00000324109.4_Missense_Mutation_p.R454S			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	454					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TGGCATAGTCTCTAGTCCTTG	0.493000													77	52					0	0	1	0	0
SLC39A14	23516	broad.mit.edu	37	8	22273316	22273316	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:22273316C>T	ENST00000381237.1	+	6	904	c.785C>T	c.(784-786)tCg>tTg	p.S262L	SLC39A14_ENST00000240095.6_Missense_Mutation_p.S262L|SLC39A14_ENST00000289952.5_Missense_Mutation_p.S262L|SLC39A14_ENST00000359741.5_Missense_Mutation_p.S262L	NM_001128431.2	NP_001121903.1	Q15043	S39AE_HUMAN	solute carrier family 39 (zinc transporter), member 14	262						endoplasmic reticulum|Golgi apparatus|integral to membrane|lamellipodium|plasma membrane	zinc ion transmembrane transporter activity			NS(1)|endometrium(4)|large_intestine(2)|lung(4)|prostate(1)	12				Colorectal(74;0.019)|COAD - Colon adenocarcinoma(73;0.0731)		GCCTCTGAGTCGCTTCCCTCC	0.552000													8	39					0	0	1	0	0
NBEAP1	606	broad.mit.edu	37	15	20876489	20876489	+	RNA	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:20876489G>T	ENST00000556948.1	-	0	111																											AACAAAATATGATCACAAAGC	0.328000													20	87					3.62473e-10	4.22018e-10	1	1	0
TRAF6	7189	broad.mit.edu	37	11	36520173	36520173	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:36520173C>T	ENST00000526995.1	-	3	560	c.314G>A	c.(313-315)tGt>tAt	p.C105Y	TRAF6_ENST00000348124.5_Missense_Mutation_p.C105Y	NM_004620.3	NP_004611.1	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	105	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)	27	all_lung(20;0.211)	all_hematologic(20;0.107)				GTCAACTGGACATTTGTGACC	0.323000													20	16					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179529260	179529260	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:179529260C>T	ENST00000589042.1	-	168	36431	c.36207G>A	c.(36205-36207)ccG>ccA	p.P12069P	TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10216	Ig-like 80.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGAGCCTCCGGCACTTTGA	0.383000													75	77					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47548131	47548131	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:47548131C>T	ENST00000334194.3	+	4	493	c.490C>T	c.(490-492)Ctg>Ttg	p.L164L		NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	164						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						TCGGATGATGCTGGTAAGAGG	0.473000													38	42					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7629799	7629799	+	Silent	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:7629799G>C	ENST00000340209.4	+	3	603	c.306G>C	c.(304-306)ccG>ccC	p.P102P	RBFOX1_ENST00000552089.1_Silent_p.P132P|RBFOX1_ENST00000311745.5_Silent_p.P117P|RBFOX1_ENST00000550418.1_Silent_p.P97P|RBFOX1_ENST00000422070.4_Silent_p.P140P|RBFOX1_ENST00000547338.1_Silent_p.P97P|RBFOX1_ENST00000436368.2_Silent_p.P117P|RBFOX1_ENST00000535565.2_Intron|RBFOX1_ENST00000355637.4_Silent_p.P117P|RBFOX1_ENST00000553186.1_Silent_p.P97P|RBFOX1_ENST00000547372.1_Silent_p.P140P			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	97					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						ACGCAGCACCGACGGATGGCC	0.522000													36	82					0	0	1	0	0
TXNRD2	10587	broad.mit.edu	37	22	19868178	19868178	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr22:19868178G>A	ENST00000535882.1	-	13	1145	c.1146C>T	c.(1144-1146)ttC>ttT	p.F382F	TXNRD2_ENST00000542719.1_Silent_p.F353F|TXNRD2_ENST00000400525.1_Silent_p.F360F|TXNRD2_ENST00000400518.1_Silent_p.F353F|TXNRD2_ENST00000400521.1_Silent_p.F383F|TXNRD2_ENST00000400519.1_Silent_p.F382F			Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2	383					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|urinary_tract(2)	30	Colorectal(54;0.0993)					AGGACCCGCCGAAGAGCCGCT	0.627000													3	40					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18725278	18725278	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:18725278C>T	ENST00000440756.2	-	4	1642	c.1540G>A	c.(1540-1542)Gtg>Atg	p.V514M	PSD3_ENST00000523619.1_Missense_Mutation_p.V449M|PSD3_ENST00000327040.8_Missense_Mutation_p.V514M			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	514					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TAGCCCATCACGATGCCACCA	0.517000													65	85					0	0	1	0	0
ZNF682	91120	broad.mit.edu	37	19	20117004	20117004	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:20117004C>G	ENST00000397165.2	-	4	1467	c.1307G>C	c.(1306-1308)cGg>cCg	p.R436P	ZNF682_ENST00000397162.1_Missense_Mutation_p.R404P|ZNF682_ENST00000358523.5_Missense_Mutation_p.R404P|ZNF682_ENST00000597972.1_Missense_Mutation_p.R442P|ZNF682_ENST00000596019.1_Intron|ZNF682_ENST00000595736.1_Missense_Mutation_p.R360P	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	436					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						GTGTGAGCACCGATTAAAGGC	0.388000													28	68					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38211308	38211308	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr13:38211308C>T	ENST00000379705.3	-	11	3523	c.2666G>A	c.(2665-2667)cGa>cAa	p.R889Q	TRPC4_ENST00000358477.2_Missense_Mutation_p.R805Q|TRPC4_ENST00000355779.2_Missense_Mutation_p.R748Q|TRPC4_ENST00000379673.2_Missense_Mutation_p.R740Q|TRPC4_ENST00000338947.5_Missense_Mutation_p.R716Q|TRPC4_ENST00000379681.3_Missense_Mutation_p.R894Q|TRPC4_ENST00000447043.1_Missense_Mutation_p.R748Q|TRPC4_ENST00000379679.1_Missense_Mutation_p.R716Q|TRPC4_ENST00000426868.2_3'UTR			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	889	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AGCTAATCCTCGAGATTCCAG	0.468000													4	84					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62935925	62935925	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:62935925C>T	ENST00000514591.1	+	25	4038	c.3709C>T	c.(3709-3711)Ctg>Ttg	p.L1237L	LPHN3_ENST00000514157.1_3'UTR|LPHN3_ENST00000506746.1_Silent_p.L1339L|LPHN3_ENST00000506700.1_3'UTR|LPHN3_ENST00000507164.1_3'UTR|LPHN3_ENST00000511324.1_3'UTR|LPHN3_ENST00000506720.1_Silent_p.L1348L|LPHN3_ENST00000504896.1_3'UTR|LPHN3_ENST00000507625.1_Silent_p.L1296L|LPHN3_ENST00000508946.1_Silent_p.L1280L|LPHN3_ENST00000508693.1_3'UTR|LPHN3_ENST00000509896.1_3'UTR|LPHN3_ENST00000514996.1_Silent_p.L1271L|LPHN3_ENST00000545650.1_Silent_p.L1237L|LPHN3_ENST00000512091.1_3'UTR			Q9HAR2	LPHN3_HUMAN	latrophilin 3	1215					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						CGGCGAATACCTGAGCAACTG	0.463000													18	23					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86415962	86415962	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:86415962T>C	ENST00000361669.2	+	3	1953	c.854T>C	c.(853-855)aTt>aCt	p.I285T	AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000394720.2_Missense_Mutation_p.I283T|GRM3_ENST00000439827.1_Missense_Mutation_p.I285T|GRM3_ENST00000536043.1_Missense_Mutation_p.I157T|GRM3_ENST00000546348.1_Intron	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	285					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CGGGAGCTCATTGCAGCCGCC	0.652000													37	43					0	0	1	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42292378	42292378	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:42292378G>T	ENST00000399518.3	-	8	1262	c.776C>A	c.(775-777)gCt>gAt	p.A259D	PLA2G4E_ENST00000413860.2_Missense_Mutation_p.A230D	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	252					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		GAAGCAGGCAGCGGTTTGGAA	0.602000													6	7					0.0215528	0.0218218	1	1	0
ZNF804B	219578	broad.mit.edu	37	7	88964093	88964093	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:88964093G>A	ENST00000333190.4	+	4	2406	c.1797G>A	c.(1795-1797)gaG>gaA	p.E599E		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	599						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ATAGTAGTGAGAACAAACTTA	0.383000										HNSCC(36;0.09)			24	35					0	0	1	0	0
PAGE3	139793	broad.mit.edu	37	X	55287042	55287042	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:55287042C>A	ENST00000374951.1	-	4	552	c.244G>T	c.(244-246)Ggt>Tgt	p.G82C	PAGE3_ENST00000519203.1_Missense_Mutation_p.G82C					P antigen family, member 3 (prostate associated)											endometrium(1)|kidney(1)|lung(1)	3						CCACGTTCACCCCCAGTCTTT	0.378000													11	8					3.86212e-05	4.13394e-05	1	1	0
TP53	7157	broad.mit.edu	37	17	7577610	7577610	+	Splice_Site	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:7577610T>A	ENST00000420246.2	-	7	805		c.e7-2		TP53_ENST00000574684.1_Splice_Site|TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000413465.2_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(43)|p.0?(8)|p.V225fs*24(1)|p.E224_V225insXX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGAGCCAACCTAGGAGATAAC	0.522000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			86	19					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143913225	143913225	+	Splice_Site	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:143913225G>C	ENST00000409869.1	+	3	342		c.e3+1		ARHGAP15_ENST00000295095.6_Splice_Site			Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15						regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		CACTGAACCTGTAAGTCAAAT	0.383000													19	43					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147113786	147113786	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:147113786G>T	ENST00000383075.3	-	3	1053	c.541C>A	c.(541-543)Cag>Aag	p.Q181K	ZIC4_ENST00000525172.2_Missense_Mutation_p.Q231K|ZIC4_ENST00000484399.1_Missense_Mutation_p.Q181K|ZIC4_ENST00000473123.1_Missense_Mutation_p.Q181K|ZIC4_ENST00000491672.1_Intron|ZIC4_ENST00000425731.3_Missense_Mutation_p.Q219K	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	181						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						GGCTTTCCCTGGCGCGGACAC	0.592000													101	155					1.2656e-43	1.88165e-43	1	1	0
SHPRH	257218	broad.mit.edu	37	6	146268684	146268684	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:146268684A>G	ENST00000367503.3	-	6	1555	c.1157T>C	c.(1156-1158)cTg>cCg	p.L386P	SHPRH_ENST00000367505.2_Missense_Mutation_p.L386P|SHPRH_ENST00000275233.7_Missense_Mutation_p.L386P|SHPRH_ENST00000438092.2_Missense_Mutation_p.L386P	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	386	Helicase ATP-binding; first part.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TGTCAGAATCAGAGCCAAAAC	0.483000													41	64					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53663740	53663740	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:53663740G>A	ENST00000257934.4	+	3	1105	c.1014G>A	c.(1012-1014)gaG>gaA	p.E338E	ESPL1_ENST00000552462.1_Silent_p.E338E	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	338					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						CATTGTATGAGAGCTGCCAGT	0.537000													15	49					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27875113	27875113	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:27875113G>C	ENST00000374011.2	-	6	4482	c.3514C>G	c.(3514-3516)Cag>Gag	p.Q1172E	AHDC1_ENST00000247087.5_Missense_Mutation_p.Q1172E|AHDC1_ENST00000482400.2_Intron	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1172							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		TGATTGAACTGGGTGCTGTCG	0.597000													20	77					0	0	1	0	0
OR13G1	441933	broad.mit.edu	37	1	247835613	247835613	+	Missense_Mutation	SNP	A	A	T	rs139644316	by1000genomes	TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:247835613A>T	ENST00000359688.2	-	1	752	c.731T>A	c.(730-732)gTg>gAg	p.V244E	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AAGGGTCACCACTGTGAGATG	0.448000													43	81					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33156797	33156797	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:33156797G>C	ENST00000341947.2	-	3	628	c.401C>G	c.(400-402)cCc>cGc	p.P134R	COL11A2_ENST00000357486.1_Missense_Mutation_p.P134R|COL11A2_ENST00000361917.1_Missense_Mutation_p.P134R|COL11A2_ENST00000374708.4_Missense_Mutation_p.P134R|COL11A2_ENST00000374713.1_Missense_Mutation_p.P134R|COL11A2_ENST00000395197.1_Missense_Mutation_p.P134R|COL11A2_ENST00000374714.1_Missense_Mutation_p.P134R|COL11A2_ENST00000395194.1_Missense_Mutation_p.P134R|COL11A2_ENST00000374712.1_Missense_Mutation_p.P134R	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	134	TSP N-terminal.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TGGCTGAGAGGGAGGTTGAGG	0.612000													55	149					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56058149	56058149	+	Silent	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:56058149A>G	ENST00000313022.2	-	1	417	c.390T>C	c.(388-390)cgT>cgC	p.R130R		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					TAACTGGGTAACGTAGAGGAC	0.443000													8	108					0	0	1	0	0
OR14C36	127066	broad.mit.edu	37	1	248512662	248512662	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:248512662A>G	ENST00000317861.1	+	1	586	c.586A>G	c.(586-588)Atg>Gtg	p.M196V		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						CAATGAGGTCATGATTGTTGT	0.498000													33	75					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96021458	96021458	+	Silent	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:96021458T>C	ENST00000297954.4	+	11	2628	c.2628T>C	c.(2626-2628)atT>atC	p.I876I	WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000427277.2_Silent_p.I488I|WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000395477.2_Silent_p.I876I|WNK2_ENST00000349097.3_Silent_p.I488I			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	876					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						GCCGGACCATTGTGCCAAATG	0.706000													25	31					0	0	1	0	0
IFIT1	3434	broad.mit.edu	37	10	91163206	91163206	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:91163206A>G	ENST00000546318.1	+	2	2368	c.1081A>G	c.(1081-1083)Aag>Gag	p.K361E	IFIT1_ENST00000371804.3_Missense_Mutation_p.K392E|LIPA_ENST00000371837.1_Intron	NM_001270928.1|NM_001270929.1|NM_001270930.1	NP_001257857.1|NP_001257858.1|NP_001257859.1	P09914	IFIT1_HUMAN	interferon-induced protein with tetratricopeptide repeats 1	392					cellular response to exogenous dsRNA|intracellular transport of viral proteins in host cell|negative regulation of defense response to virus by host|negative regulation of helicase activity|negative regulation of protein binding|negative regulation of viral genome replication|positive regulation of viral genome replication|response to virus|type I interferon-mediated signaling pathway	cytoplasm	protein binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)	15						GGAATTTCAAAAGAAATCTGA	0.308000													22	17					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56058167	56058167	+	Silent	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:56058167A>C	ENST00000313022.2	-	1	399	c.372T>G	c.(370-372)gcT>gcG	p.A124A		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					GACTGCAGATAGCTACGTAGC	0.448000													8	121					0	0	1	0	0
LRRC15	131578	broad.mit.edu	37	3	194080707	194080707	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:194080707G>C	ENST00000347624.3	-	2	1151	c.1066C>G	c.(1066-1068)Ctg>Gtg	p.L356V	LRRC15_ENST00000428839.1_Missense_Mutation_p.L362V|LRRC15_ENST00000439944.2_Missense_Mutation_p.L362V	NM_130830.4	NP_570843.2	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15	356						integral to membrane				biliary_tract(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(20)|ovary(4)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		TTCCCGTCCAGGTCCTGCAGT	0.577000													37	55					0	0	1	0	0
AEBP1	165	broad.mit.edu	37	7	44147650	44147650	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:44147650G>T	ENST00000223357.3	+	6	1212	c.907G>T	c.(907-909)Ggt>Tgt	p.G303C		NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	303	Pro-rich.				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						CCCTGACTATGGTGATGGTTA	0.652000													8	3					1.12685e-05	1.22593e-05	1	1	0
NALCN	259232	broad.mit.edu	37	13	101997662	101997662	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr13:101997662C>A	ENST00000251127.6	-	7	835	c.754G>T	c.(754-756)Gga>Tga	p.G252*	NALCN_ENST00000470333.1_5'UTR|NALCN_ENST00000376196.3_Nonsense_Mutation_p.G252*	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	252						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTGCTAAGTCCCAGATCTTCA	0.428000													39	81					1.30091e-30	1.87681e-30	1	1	0
ROS1	6098	broad.mit.edu	37	6	117718215	117718215	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:117718215G>T	ENST00000368508.3	-	7	840	c.642C>A	c.(640-642)agC>agA	p.S214R	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.S223R	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	214	Fibronectin type-III 2.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GTGGATCCCAGCTGACTTCCA	0.423000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								44	71					9.9998e-32	1.44552e-31	1	1	0
ABHD12	26090	broad.mit.edu	37	20	25300923	25300923	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:25300923C>A	ENST00000339157.5	-	4	726	c.454G>T	c.(454-456)Gcc>Tcc	p.A152S	ABHD12_ENST00000376542.3_Missense_Mutation_p.A152S	NM_001042472.2	NP_001035937.1	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12	152						integral to membrane	acylglycerol lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	12						TTGCCTTGGGCGTTCTTCCAC	0.582000													18	39					5.35267e-07	5.93837e-07	1	1	0
LCA5	167691	broad.mit.edu	37	6	80198927	80198927	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:80198927G>C	ENST00000392959.1	-	8	1716	c.1105C>G	c.(1105-1107)Caa>Gaa	p.Q369E	LCA5_ENST00000467898.2_Missense_Mutation_p.Q369E|LCA5_ENST00000369846.4_Missense_Mutation_p.Q369E	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	369					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		TTTTGAGATTGCAAGTCCTAT	0.348000													16	41					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73181874	73181874	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:73181874G>T	ENST00000545377.1	+	25	3431	c.3255G>T	c.(3253-3255)agG>agT	p.R1085S	ARHGEF28_ENST00000513042.2_Missense_Mutation_p.R1085S|ARHGEF28_ENST00000437974.1_Missense_Mutation_p.R1085S|ARHGEF28_ENST00000296794.6_Missense_Mutation_p.R1085S|ARHGEF28_ENST00000296799.4_Missense_Mutation_p.R772S|ARHGEF28_ENST00000512883.1_Missense_Mutation_p.R49S|ARHGEF28_ENST00000287898.5_Missense_Mutation_p.R1085S|ARHGEF28_ENST00000426542.2_Missense_Mutation_p.R1085S	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		GTGAAGAAAGGACTCTGTTAT	0.388000													27	20					2.44723e-14	3.06955e-14	1	1	0
SERBP1	26135	broad.mit.edu	37	1	67880980	67880980	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:67880980G>C	ENST00000370994.4	-	7	1090	c.976C>G	c.(976-978)Cca>Gca	p.P326A	SERBP1_ENST00000361219.6_Missense_Mutation_p.P332A|SERBP1_ENST00000370990.5_Missense_Mutation_p.P341A|SERBP1_ENST00000370995.2_Missense_Mutation_p.P347A	NM_001018067.1|NM_001018068.1|NM_001018069.1|NM_015640.3	NP_001018077.1|NP_001018078.1|NP_001018079.1|NP_056455.3	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1	347					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	13						TCATTTGCTGGCTTCCGGAAA	0.468000													41	62					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	78150894	78150894	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:78150894T>C	ENST00000354212.4	-	4	860	c.607A>G	c.(607-609)Ata>Gta	p.I203V	MAGI2_ENST00000535697.1_Missense_Mutation_p.I40V|MAGI2_ENST00000517762.1_5'UTR|MAGI2_ENST00000522391.1_Missense_Mutation_p.I203V|MAGI2_ENST00000419488.1_Missense_Mutation_p.I203V|MAGI2_ENST00000536571.1_Missense_Mutation_p.I35V	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	203	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CCTGGAAGTATCTGGTCTGTT	0.448000													51	204					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102464297	102464297	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:102464297G>T	ENST00000260228.2	-	8	1132	c.1120C>A	c.(1120-1122)Caa>Aaa	p.Q374K		NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	374	Hemopexin-like 2.				proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CCTTGCATTTGGAATCCTCTT	0.443000													28	57					1.32181e-22	1.83445e-22	1	1	0
FRY	10129	broad.mit.edu	37	13	32813404	32813404	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr13:32813404T>A	ENST00000380250.3	+	45	6930	c.6434T>A	c.(6433-6435)gTc>gAc	p.V2145D		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCACTGAATGTCTTGTGTCTC	0.393000													38	37					0	0	1	0	0
OR10H1	26539	broad.mit.edu	37	19	15918704	15918704	+	Silent	SNP	G	G	A	rs142314142	byFrequency	TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:15918704G>A	ENST00000334920.2	-	1	232	c.144C>T	c.(142-144)acC>acT	p.T48T		NM_013940.2	NP_039228.1	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H, member 1	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|skin(2)|urinary_tract(1)	29						CGCTCCAGACGGTGGCCATGA	0.617000													49	101					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30791878	30791878	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:30791878T>A	ENST00000383096.3	-	20	2402	c.2220A>T	c.(2218-2220)aaA>aaT	p.K740N	CCDC178_ENST00000403303.1_Missense_Mutation_p.K740N|CCDC178_ENST00000579947.1_Missense_Mutation_p.K740N|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000406524.2_Missense_Mutation_p.K740N|CCDC178_ENST00000402325.1_Missense_Mutation_p.K740N|CCDC178_ENST00000583930.1_Missense_Mutation_p.K740N|CCDC178_ENST00000300227.8_Missense_Mutation_p.K702N					coiled-coil domain containing 178																		CTTGAAGAGTTTTTTGTCTTA	0.323000													18	14					0	0	1	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798824	55798824	+	Silent	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:55798824T>C	ENST00000313555.1	+	1	930	c.930T>C	c.(928-930)taT>taC	p.Y310Y		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	310			Y -> C (in dbSNP:rs17600939).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					GAATTGGATATTCAAATGAAT	0.279000													23	37					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32265700	32265700	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:32265700C>T	ENST00000360482.2	-	5	1774	c.1645G>A	c.(1645-1647)Ggt>Agt	p.G549S	SPOCD1_ENST00000373648.2_Missense_Mutation_p.G490S|SPOCD1_ENST00000257100.3_Missense_Mutation_p.G42S|SPOCD1_ENST00000533231.1_Missense_Mutation_p.G549S	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	549				G -> D (in Ref. 1; BAC04981).	transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		GAGAGGCCACCAGGGTCCCCT	0.622000													11	20					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86479803	86479803	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:86479803C>A	ENST00000361669.2	+	5	3608	c.2509C>A	c.(2509-2511)Cac>Aac	p.H837N	GRM3_ENST00000394720.2_Missense_Mutation_p.T479K|GRM3_ENST00000439827.1_Missense_Mutation_p.T481K|GRM3_ENST00000536043.1_Missense_Mutation_p.H709N|GRM3_ENST00000546348.1_Missense_Mutation_p.H429N	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	837					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGTTGTCACACACAGACTGCA	0.478000													15	63					0.000308642	0.000325121	1	1	0
FAM47B	170062	broad.mit.edu	37	X	34962224	34962224	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:34962224G>T	ENST00000329357.5	+	1	1312	c.1276G>T	c.(1276-1278)Gag>Tag	p.E426*		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	426										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TCTCTGCCCGGAGCCTACCAA	0.547000													39	20					1.58521e-26	2.22967e-26	1	1	0
COL4A3	1285	broad.mit.edu	37	2	228104886	228104886	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:228104886G>A	ENST00000396578.3	+	3	334	c.172G>A	c.(172-174)Ggt>Agt	p.G58S	AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000606119.1_RNA|AC097662.2_ENST00000437673.1_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	58	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TGGACCCCCCGGTTCTCCTGG	0.522000													3	10					0	0	1	0	0
YAF2	10138	broad.mit.edu	37	12	42554626	42554626	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:42554626G>C	ENST00000327791.4	-	5	303	c.236C>G	c.(235-237)cCa>cGa	p.P79R	YAF2_ENST00000380788.3_Missense_Mutation_p.P94R|YAF2_ENST00000534854.2_Missense_Mutation_p.P103R|YAF2_ENST00000380790.4_Missense_Mutation_p.P61R|YAF2_ENST00000442791.3_Missense_Mutation_p.P127R			Q8IY57	YAF2_HUMAN	YY1 associated factor 2	103					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|zinc ion binding			cervix(2)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)	8	all_cancers(12;0.000425)	Lung NSC(34;0.0402)|all_lung(34;0.057)		GBM - Glioblastoma multiforme(48;0.0514)		TTTCAATCTTGGCCTAAACAT	0.308000													6	24					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	84027932	84027932	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:84027932G>C	ENST00000280241.8	-	1	256	c.257C>G	c.(256-258)aCc>aGc	p.T86S	DLG2_ENST00000532653.1_Intron|DLG2_ENST00000524982.1_Intron|DLG2_ENST00000398301.2_Missense_Mutation_p.T86S|DLG2_ENST00000398309.2_Intron|DLG2_ENST00000376104.2_Intron|DLG2_ENST00000543673.1_Intron	NM_001206769.1	NP_001193698.1	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	0						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TTTGCCCTTGGTGCTCGTCTT	0.577000													28	47					0	0	1	0	0
KCNE4	23704	broad.mit.edu	37	2	223917882	223917882	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:223917882G>C	ENST00000281830.3	+	2	818	c.487G>C	c.(487-489)Gcg>Ccg	p.A163P	KCNE4_ENST00000488477.2_Intron|KCNE4_ENST00000604125.1_Missense_Mutation_p.A112P			Q8WWG9	KCNE4_HUMAN	potassium voltage-gated channel, Isk-related family, member 4	112						integral to membrane	voltage-gated potassium channel activity			large_intestine(2)|lung(5)|ovary(2)|skin(1)	10		Renal(207;0.0183)|Lung NSC(271;0.137)|all_lung(227;0.175)		Epithelial(121;4.48e-11)|all cancers(144;2.88e-08)|Lung(261;0.00688)|LUSC - Lung squamous cell carcinoma(224;0.008)		CGTGGCGCCCGCGCTGTCCTG	0.672000													16	61					0	0	1	0	0
TMEM176A	55365	broad.mit.edu	37	7	150501523	150501523	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:150501523T>A	ENST00000484928.1	+	6	1210	c.629T>A	c.(628-630)cTg>cAg	p.L210Q	TMEM176A_ENST00000004103.3_Missense_Mutation_p.L210Q|TMEM176A_ENST00000461345.1_Missense_Mutation_p.L151Q			Q96HP8	T176A_HUMAN	transmembrane protein 176A	210						integral to membrane				breast(1)|endometrium(1)|lung(7)|ovary(2)|stomach(1)	12			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTGACCCCTCTGTGGCTGTAC	0.552000													40	54					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4919539	4919539	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:4919539A>G	ENST00000433855.1	+	1	1198	c.332A>G	c.(331-333)aAc>aGc	p.N111S	KCNA6_ENST00000280684.3_Missense_Mutation_p.N111S	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	111						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						AGGCCGGTCAACGTGCCCCTG	0.662000										HNSCC(72;0.22)			38	90					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95669349	95669349	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:95669349G>T	ENST00000298912.4	-	9	2450	c.2337C>A	c.(2335-2337)agC>agA	p.S779R		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	779						integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		AACTGGAGCTGCTCTGAGAGC	0.587000													24	16					1.96895e-08	2.22153e-08	1	1	0
SCN7A	6332	broad.mit.edu	37	2	167273409	167273409	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:167273409G>T	ENST00000409855.1	-	20	3348	c.3222C>A	c.(3220-3222)atC>atA	p.I1074I		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	1074					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						CTACTCCCATGATACTAAAAA	0.398000													12	17					0.00185496	0.0019262	1	1	0
NPTX2	4885	broad.mit.edu	37	7	98256641	98256641	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:98256641C>A	ENST00000265634.3	+	4	1218	c.1053C>A	c.(1051-1053)atC>atA	p.I351I		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	351	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GCGTGCTGATCCTTGGACAAG	0.672000													4	41					0.00909568	0.00923484	1	1	0
PMEPA1	56937	broad.mit.edu	37	20	56234686	56234686	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:56234686C>A	ENST00000341744.3	-	2	496	c.177G>T	c.(175-177)acG>acT	p.T59T	PMEPA1_ENST00000472841.1_5'UTR|PMEPA1_ENST00000395814.1_Silent_p.T9T|PMEPA1_ENST00000265626.4_Silent_p.T9T|PMEPA1_ENST00000347215.4_Silent_p.T24T|PMEPA1_ENST00000395816.3_Silent_p.T9T	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	59					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding	p.T59T(1)		breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						TCAGCAGGCACGTGatcacca	0.582000													11	19					4.84862e-15	6.17712e-15	1	1	0
MFNG	4242	broad.mit.edu	37	22	37882099	37882099	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr22:37882099G>T	ENST00000356998.3	-	1	340	c.117C>A	c.(115-117)ccC>ccA	p.P39P	MFNG_ENST00000416983.3_Silent_p.P39P	NM_002405.3	NP_002396.2	O00587	MFNG_HUMAN	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	39					pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			large_intestine(2)|lung(2)|skin(1)	5	Melanoma(58;0.0574)					GGCTCAGCTCGGGGGTCCCTT	0.662000													19	25					1.96292e-10	2.30375e-10	1	1	0
COPA	1314	broad.mit.edu	37	1	160276193	160276193	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:160276193G>A	ENST00000241704.7	-	15	1622	c.1393C>T	c.(1393-1395)Ctg>Ttg	p.L465L	COPA_ENST00000368069.3_Silent_p.L465L	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	465					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCTCGAAGCAGGAGATTGCCT	0.488000													38	126					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70541742	70541742	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:70541742G>T	ENST00000260128.4	+	19	2829	c.2112G>T	c.(2110-2112)gaG>gaT	p.E704D	SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000402687.4_Missense_Mutation_p.E704D|SULF1_ENST00000419716.3_Missense_Mutation_p.E704D|SULF1_ENST00000458141.2_Missense_Mutation_p.E704D	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	704					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GGAACAGGGAGGCTGCTCAGG	0.453000													12	43					1.5842e-08	1.79576e-08	1	1	0
PROC	5624	broad.mit.edu	37	2	128186316	128186316	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:128186316C>A	ENST00000453608.2	+	8	1353	c.1345C>A	c.(1345-1347)Cgg>Agg	p.R449R	PROC_ENST00000422777.3_Silent_p.R394R|PROC_ENST00000234071.3_Silent_p.R394R|PROC_ENST00000409048.1_Silent_p.R428R			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	394	Peptidase S1.				blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	CCTCGGGGACCGGCAGGATGC	0.637000													64	127					1.20869e-33	1.75766e-33	1	1	0
ATP9A	10079	broad.mit.edu	37	20	50244148	50244148	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:50244148C>T	ENST00000338821.5	-	17	2100	c.1836G>A	c.(1834-1836)caG>caA	p.Q612Q	ATP9A_ENST00000402822.1_Silent_p.Q491Q|ATP9A_ENST00000311637.5_Silent_p.Q476Q	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	612					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						CTTCAAAGTCCTGATACTGCT	0.547000													149	249					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97133811	97133811	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:97133811C>T	ENST00000524981.3	+	18	2396	c.2396C>T	c.(2395-2397)aCa>aTa	p.T799I				Q6ZTY8	CL063_HUMAN		773										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						CAGGATGACACAGAGAATCCT	0.323000													13	21					0	0	1	0	0
FMN1	342184	broad.mit.edu	37	15	33218463	33218463	+	Splice_Site	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:33218463C>A	ENST00000334528.9	-	6	2469		c.e6-1		FMN1_ENST00000559047.1_Splice_Site|FMN1_ENST00000561249.1_Splice_Site	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1						actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		ATTTGATGATCTAAAATTAGA	0.313000													5	12					8.12818e-05	8.63694e-05	1	1	0
SPTSSB	165679	broad.mit.edu	37	3	161064099	161064099	+	Missense_Mutation	SNP	G	G	C	rs144350794		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:161064099G>C	ENST00000359175.4	-	3	1583	c.13C>G	c.(13-15)Cgt>Ggt	p.R5G	SPTSSB_ENST00000497137.1_Missense_Mutation_p.R5G	NM_001040100.1	NP_001035189.1	Q8NFR3	SSPTB_HUMAN	serine palmitoyltransferase, small subunit B	5					sphingolipid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	protein binding										TCCTTCACACGCCTCAAATCC	0.408000													35	30					0	0	1	0	0
RNASEL	6041	broad.mit.edu	37	1	182555531	182555531	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:182555531C>T	ENST00000367559.3	-	2	664	c.411G>A	c.(409-411)aaG>aaA	p.K137K	RNASEL_ENST00000539397.1_Silent_p.K137K|RNASEL_ENST00000444138.1_Silent_p.K137K	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	137					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						GGGCTTTGACCTTACCATACA	0.458000													34	22					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39893453	39893453	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:39893453C>T	ENST00000373186.4	-	2	524	c.387G>A	c.(385-387)ccG>ccA	p.P129P	MOCS1_ENST00000308559.7_Silent_p.P129P|MOCS1_ENST00000432280.2_Silent_p.P100P|MOCS1_ENST00000373175.4_Silent_p.P100P|MOCS1_ENST00000373195.3_Silent_p.P42P|MOCS1_ENST00000340692.5_Silent_p.P129P|MOCS1_ENST00000373188.2_Silent_p.P129P|MOCS1_ENST00000425303.2_Silent_p.P129P	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	129	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					GCCGGATAAGCGGCTCTCCAC	0.607000													11	32					0	0	1	0	0
TRBV7-4	28594	broad.mit.edu	37	7	142176768	142176768	+	RNA	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:142176768C>A	ENST00000390369.2	-	0	22																											CAGGACCACCCAGCAGAGGAG	0.537000													20	58					9.95505e-16	1.28169e-15	1	1	0
MMRN1	22915	broad.mit.edu	37	4	90848950	90848950	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:90848950G>A	ENST00000394980.1	+	6	1279	c.960G>A	c.(958-960)gtG>gtA	p.V320V	MMRN1_ENST00000264790.2_Silent_p.V320V|MMRN1_ENST00000394981.1_Silent_p.V286V|MMRN1_ENST00000508372.1_Silent_p.V62V			Q13201	MMRN1_HUMAN	multimerin 1	320					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		ATGCAGAAGTGATGCAAAAAA	0.338000													36	66					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100696663	100696663	+	Missense_Mutation	SNP	G	G	A	rs139724548		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:100696663G>A	ENST00000306151.4	+	11	13373	c.13309G>A	c.(13309-13311)Gac>Aac	p.D4437N		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4437						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GCAAGAAGAGGACAGTGGACC	0.463000													15	35					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35093918	35093918	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:35093918G>C	ENST00000378617.3	-	4	1153	c.759C>G	c.(757-759)agC>agG	p.S253R	PIGO_ENST00000361778.2_Missense_Mutation_p.S253R|PIGO_ENST00000341666.3_Missense_Mutation_p.S253R|PIGO_ENST00000298004.5_Missense_Mutation_p.S253R	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	253					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GGTCCATCTGGCTAAGTTTCT	0.527000													42	39					0	0	1	0	0
TBCK	93627	broad.mit.edu	37	4	107154148	107154148	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:107154148C>T	ENST00000273980.4	-	18	2033	c.1586G>A	c.(1585-1587)aGg>aAg	p.R529K	TBCK_ENST00000432496.2_Missense_Mutation_p.R529K|TBCK_ENST00000394708.2_Missense_Mutation_p.R529K|TBCK_ENST00000394706.3_Missense_Mutation_p.R490K|TBCK_ENST00000361687.4_Missense_Mutation_p.R466K			Q8TEA7	TBCK_HUMAN	TBC1 domain containing kinase	529	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	25						TAATACACGCCTAAATTTTGC	0.368000													37	61					0	0	1	0	0
STX4	6810	broad.mit.edu	37	16	31051077	31051077	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:31051077A>G	ENST00000394998.1	+	11	1184	c.841A>G	c.(841-843)Acc>Gcc	p.T281A	STX4_ENST00000493902.1_3'UTR|STX4_ENST00000313843.3_Missense_Mutation_p.T283A	NM_001272096.1	NP_001259025.1	Q12846	STX4_HUMAN	syntaxin 4	283	Interaction with CENPF (By similarity).				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity			NS(2)|breast(1)|large_intestine(3)|lung(3)	9						TGTGTCCATCACCGTCGTCCT	0.602000													99	160					0	0	1	0	0
KLK13	26085	broad.mit.edu	37	19	51563204	51563204	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:51563204T>C	ENST00000595793.1	-	3	428	c.386A>G	c.(385-387)gAg>gGg	p.E129G	KLK13_ENST00000595547.1_Intron|KLK13_ENST00000596955.1_Missense_Mutation_p.E129G|KLK13_ENST00000335422.3_Intron	NM_015596.1	NP_056411.1	Q9UKR3	KLK13_HUMAN	kallikrein-related peptidase 13	129	Peptidase S1.				proteolysis		protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|skin(1)	16		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)		GGACTGCAGCTCCAGAAGCAT	0.607000													13	78					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28326816	28326816	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:28326816C>A	ENST00000354638.3	-	2	360	c.205G>T	c.(205-207)Gct>Tct	p.A69S	OCA2_ENST00000353809.5_Missense_Mutation_p.A69S|OCA2_ENST00000382996.2_Missense_Mutation_p.A69S	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	69					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AGGAATGAAGCAAACTCCTGG	0.582000									Oculocutaneous Albinism				12	6					7.03913e-09	8.029e-09	1	1	0
MAGEC3	139081	broad.mit.edu	37	X	140984864	140984864	+	Silent	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:140984864T>C	ENST00000298296.1	+	7	1320	c.1320T>C	c.(1318-1320)gcT>gcC	p.A440A	MAGEC3_ENST00000443323.2_Silent_p.A62A|MAGEC3_ENST00000536088.1_Silent_p.A142A|MAGEC3_ENST00000409007.1_Silent_p.A142A|MAGEC3_ENST00000483584.1_3'UTR|MAGEC3_ENST00000544766.1_Silent_p.A142A	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	440										NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					AGGATACAGCTACTTGGCATG	0.517000													20	18					0	0	1	0	0
CAPN9	10753	broad.mit.edu	37	1	230903329	230903329	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:230903329C>G	ENST00000354537.1	+	5	661	c.579C>G	c.(577-579)atC>atG	p.I193M	RP11-99J16__A.2_ENST00000412344.1_RNA|CAPN9_ENST00000366666.2_Missense_Mutation_p.I130M|CAPN9_ENST00000271971.2_Missense_Mutation_p.I193M	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	193	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				GCAGCGCCATCGAGGCCATGG	0.557000													20	113					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94540062	94540062	+	Missense_Mutation	SNP	G	G	A	rs141443113		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:94540062G>A	ENST00000289495.5	+	1	853	c.637G>A	c.(637-639)Gat>Aat	p.D213N	PPP1R9A_ENST00000433881.1_Missense_Mutation_p.D213N|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.D213N|PPP1R9A_ENST00000340694.4_Missense_Mutation_p.D213N|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.D213N|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.D213N	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	213						cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			TGAGAACACTGATTCTCCCAG	0.453000										HNSCC(28;0.073)			19	21					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169696638	169696638	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:169696638C>A	ENST00000333360.7	-	10	1636	c.1497G>T	c.(1495-1497)ccG>ccT	p.P499P	SELE_ENST00000367780.4_Silent_p.P374P|SELE_ENST00000367774.1_Silent_p.P373P|SELE_ENST00000367776.1_Silent_p.P436P|SELE_ENST00000367777.1_Silent_p.P436P|SELE_ENST00000367782.4_Silent_p.P436P|SELE_ENST00000367781.4_Silent_p.P436P|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367779.4_Silent_p.P373P|SELE_ENST00000367775.1_Silent_p.P374P	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	499	Sushi 6.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					TGATCTTTCCCGGAACTGCCA	0.483000													13	65					4.3838e-07	4.87089e-07	1	1	0
HIST1H2BB	3018	broad.mit.edu	37	6	26043824	26043824	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:26043824T>A	ENST00000357905.2	-	1	61	c.62A>T	c.(61-63)aAg>aTg	p.K21M		NM_021062.2	NP_066406.1	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	21					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7						CTTCTGCGCCTTAGTGATAGC	0.483000													71	117					0	0	1	0	0
WIPF1	7456	broad.mit.edu	37	2	175427287	175427287	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:175427287G>A	ENST00000392547.2	-	8	1599	c.1500C>T	c.(1498-1500)ccC>ccT	p.P500P	WIPF1_ENST00000272746.5_Silent_p.P500P|AC018890.6_ENST00000412835.1_RNA|AC018890.6_ENST00000442996.1_RNA|WIPF1_ENST00000359761.3_Silent_p.P500P|WIPF1_ENST00000392546.2_Silent_p.P500P	NM_003387.4	NP_003378.3	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	500					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						ACCTCGGGATGGGAGGGAGTG	0.478000													9	13					0	0	1	0	0
KRTAP4-2	85291	broad.mit.edu	37	17	39334273	39334273	+	Silent	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:39334273C>G	ENST00000377726.2	-	1	187	c.144G>C	c.(142-144)ccG>ccC	p.P48P		NM_033062.3	NP_149051.1	Q9BYR5	KRA42_HUMAN	keratin associated protein 4-2	48	20 X 5 AA repeats OF C-C-[GRQVS]-[SPT]- [VSTQ].					keratin filament		p.P165P(1)|p.P48P(1)		kidney(2)|lung(4)|upper_aerodigestive_tract(1)	7		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			GGCAGCACTGCGGTCTGCAGC	0.672000													31	97					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701420	56701420	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:56701420G>T	ENST00000586855.2	-	5	1577	c.1264C>A	c.(1264-1266)Cac>Aac	p.H422N	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.H422N			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	422					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						GTGGACTCGTGGGCGAACCGC	0.562000													30	40					1.08312e-15	1.38715e-15	1	1	0
TMEM2	23670	broad.mit.edu	37	9	74324291	74324291	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:74324291C>A	ENST00000377044.4	-	17	3408	c.2869G>T	c.(2869-2871)Gtg>Ttg	p.V957L	TMEM2_ENST00000377066.5_Missense_Mutation_p.V894L	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	957						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TATCCTGTCACAGAGCCATCA	0.448000													46	62					1.0096e-33	1.47107e-33	1	1	0
LRP11	84918	broad.mit.edu	37	6	150157413	150157413	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:150157413C>A	ENST00000239367.2	-	5	1065	c.1060G>T	c.(1060-1062)Gta>Tta	p.V354L	LRP11_ENST00000546019.1_Missense_Mutation_p.V99L	NM_032832.5	NP_116221.3	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein 11	354						integral to membrane	receptor activity			cervix(1)|kidney(5)|large_intestine(1)|lung(1)	8		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		GTGTGGGTTACCATCTTGCGG	0.512000													16	37					8.60227e-14	1.06255e-13	1	1	0
MUC16	94025	broad.mit.edu	37	19	9088024	9088024	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:9088024G>A	ENST00000397910.4	-	1	3994	c.3791C>T	c.(3790-3792)aCc>aTc	p.T1264I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1264	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAGTTTGATGGTGCTTGGACT	0.498000													177	421					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152453256	152453256	+	Splice_Site	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:152453256C>A	ENST00000367255.5	-	144	26696		c.e144+1		SYNE1_ENST00000347037.5_Splice_Site|SYNE1_ENST00000354674.4_Splice_Site|SYNE1_ENST00000356820.4_Splice_Site|SYNE1_ENST00000448038.1_Splice_Site|SYNE1_ENST00000539504.1_Splice_Site|SYNE1_ENST00000341594.5_Splice_Site|SYNE1_ENST00000265368.4_Splice_Site|SYNE1_ENST00000423061.1_Splice_Site	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGAAAGTTACCGTTTTCTGT	0.532000										HNSCC(10;0.0054)			27	74					4.59853e-10	5.33692e-10	1	1	0
PLCB1	23236	broad.mit.edu	37	20	8113331	8113331	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:8113331G>T	ENST00000378641.3	+	1	508	c.33G>T	c.(31-33)ttG>ttT	p.L11F	PLCB1_ENST00000378637.2_Missense_Mutation_p.L11F|PLCB1_ENST00000338037.6_Missense_Mutation_p.L11F	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	11				MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDD -> MGS LQGIATKILIRILSDALIRKETDLKS (in Ref. 2; AAF86613).	activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TGCACGCCTTGCAACTCAAGC	0.692000													16	11					6.49762e-13	7.91863e-13	1	1	0
MROH2B	133558	broad.mit.edu	37	5	41033142	41033142	+	Splice_Site	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:41033142C>T	ENST00000399564.4	-	23	2812		c.e23+1		MROH2B_ENST00000506092.2_Splice_Site	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TGCACACTCACCAGCATGTAA	0.443000													43	29					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130648746	130648746	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:130648746T>A	ENST00000229030.4	+	1	1743	c.1259T>A	c.(1258-1260)cTg>cAg	p.L420Q	FZD10_ENST00000539839.1_Silent_p.P387P			Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	420					brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		TTCGTGGCCCTGTTCCACATC	0.617000													21	62					0	0	1	0	0
PMS1	5378	broad.mit.edu	37	2	190719157	190719157	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:190719157G>T	ENST00000441310.2	+	9	1392	c.1159G>T	c.(1159-1161)Gtc>Ttc	p.V387F	PMS1_ENST00000421722.1_3'UTR|PMS1_ENST00000418224.3_Missense_Mutation_p.V211F|PMS1_ENST00000432292.3_Missense_Mutation_p.V211F|PMS1_ENST00000447232.2_Missense_Mutation_p.V387F|PMS1_ENST00000409823.3_Missense_Mutation_p.V348F	NM_000534.4	NP_000525.1	P54277	PMS1_HUMAN	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	387					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			TGATACTTCAGTCATTCCATT	0.333000			"""Mis, N"""			"""colorectal, endometrial, ovarian"""		Direct reversal of damage;Mismatch excision repair (MMR)					21	36					7.45023e-12	8.98953e-12	1	1	0
GPC6	10082	broad.mit.edu	37	13	94197572	94197572	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr13:94197572G>T	ENST00000377047.4	+	2	832	c.217G>T	c.(217-219)Gac>Tac	p.D73Y		NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	73						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				AGAAATGGAAGACAAGTTAAG	0.398000													36	102					1.36161e-19	1.83391e-19	1	1	0
SLC12A7	10723	broad.mit.edu	37	5	1083862	1083862	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:1083862A>T	ENST00000264930.5	-	8	1170	c.1127T>A	c.(1126-1128)cTg>cAg	p.L376Q		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	376					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	AGCCTCACCCAGGAAGACACC	0.677000													18	90					0	0	1	0	0
MRPS35	60488	broad.mit.edu	37	12	27908240	27908240	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:27908240G>T	ENST00000081029.3	+	8	900	c.829G>T	c.(829-831)Gaa>Taa	p.E277*	MRPS35_ENST00000538315.1_3'UTR	NM_021821.3	NP_068593.2	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35	277					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit				breast(1)|endometrium(1)|kidney(1)|lung(2)|urinary_tract(1)	6	Lung SC(9;0.0873)					GAAAAATATGGAAATAAATAA	0.343000													41	85					4.14481e-20	5.624e-20	1	1	0
ZNF827	152485	broad.mit.edu	37	4	146823634	146823634	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:146823634C>A	ENST00000508784.1	-	2	1004	c.777G>T	c.(775-777)aaG>aaT	p.K259N	ZNF827_ENST00000379448.4_Missense_Mutation_p.K259N|ZNF827_ENST00000513320.1_Intron			Q17R98	ZN827_HUMAN	zinc finger protein 827	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					TTTCACTGACCTTCTTGGACA	0.547000													41	22					4.90274e-10	5.67195e-10	1	1	0
CUBN	8029	broad.mit.edu	37	10	17085921	17085921	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:17085921G>T	ENST00000377833.4	-	26	3799	c.3734C>A	c.(3733-3735)cCc>cAc	p.P1245H		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1245	CUB 7.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AATAAGAGGGGGTTTCTCATC	0.428000													45	64					3.54909e-21	4.83365e-21	1	1	0
URB2	9816	broad.mit.edu	37	1	229771138	229771138	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:229771138G>T	ENST00000258243.2	+	4	914	c.778G>T	c.(778-780)Gac>Tac	p.D260Y		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	260						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						GGGGCTCTTGGACCAGCAGCA	0.567000													6	88					0.0215528	0.0218218	1	1	0
EPHA5	2044	broad.mit.edu	37	4	66270112	66270112	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:66270112G>T	ENST00000273854.3	-	8	2370	c.1770C>A	c.(1768-1770)atC>atA	p.I590I	EPHA5_ENST00000511294.1_Silent_p.I591I|EPHA5_ENST00000354839.4_Silent_p.I590I|EPHA5_ENST00000432638.2_Silent_p.I427I	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	590					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						GGAGGACGCCGATAACCACTG	0.488000										TSP Lung(17;0.13)			20	47					7.87624e-14	9.76173e-14	1	1	0
ADAMTS16	170690	broad.mit.edu	37	5	5303769	5303769	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:5303769C>A	ENST00000274181.7	+	20	3214	c.3076C>A	c.(3076-3078)Ccc>Acc	p.P1026T		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	1026	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.P1026S(2)		breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						GCAGCTGCTGCCCGACGCTGT	0.637000													58	29					6.20943e-19	8.30199e-19	1	1	0
CBX5	23468	broad.mit.edu	37	12	54639952	54639952	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:54639952T>A	ENST00000209875.4	-	4	508	c.372A>T	c.(370-372)gaA>gaT	p.E124D	CBX5_ENST00000550411.1_Missense_Mutation_p.E124D|CBX5_ENST00000439541.2_Missense_Mutation_p.E124D	NM_012117.2	NP_036249.1	P45973	CBX5_HUMAN	chromobox homolog 5	124	Chromo 2; shadow subtype.				blood coagulation|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|nuclear centromeric heterochromatin|nuclear envelope|nucleolus|transcriptional repressor complex	methylated histone residue binding|protein binding, bridging|repressing transcription factor binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	8						CAATGATCTTTTCTGGTTCCA	0.403000													48	134					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965519	88965519	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:88965519G>C	ENST00000333190.4	+	4	3832	c.3223G>C	c.(3223-3225)Ggt>Cgt	p.G1075R		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1075						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TGAATTCCCTGGTGCTTTTCC	0.353000										HNSCC(36;0.09)			28	38					0	0	1	0	0
ADCYAP1	116	broad.mit.edu	37	18	908354	908354	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr18:908354C>A	ENST00000579794.1	+	3	609	c.331C>A	c.(331-333)Cgg>Agg	p.R111R	ADCYAP1_ENST00000450565.3_Silent_p.R111R	NM_001117.3	NP_001108.2	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary)	111					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						GCTCGTGGCCCGGGGCGTGGG	0.706000													28	161					3.57733e-08	4.03002e-08	1	1	0
CCDC112	153733	broad.mit.edu	37	5	114607088	114607088	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:114607088T>C	ENST00000379611.5	-	7	1441	c.1154A>G	c.(1153-1155)aAa>aGa	p.K385R	CCDC112_ENST00000395557.4_Missense_Mutation_p.K302R|CCDC112_ENST00000512261.1_Missense_Mutation_p.K302R|CCDC112_ENST00000506442.1_Missense_Mutation_p.K302R	NM_001040440.2	NP_001035530.1	Q8NEF3	CC112_HUMAN	coiled-coil domain containing 112	302										endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|skin(1)	20		all_cancers(142;0.000523)|all_epithelial(76;6.44e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;4.09e-08)|Epithelial(69;5.28e-08)|all cancers(49;7.06e-06)		CTGATGTTTTTTCTCTTTCTC	0.348000													51	38					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769229	31769229	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:31769229C>T	ENST00000240587.4	-	2	1797	c.1470G>A	c.(1468-1470)aaG>aaA	p.K490K		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	490					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					CTTCGCCAGGCTTGTCTTTTT	0.468000													56	249					0	0	1	0	0
CMIP	80790	broad.mit.edu	37	16	81739204	81739204	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:81739204T>G	ENST00000537098.3	+	19	2264	c.2192T>G	c.(2191-2193)cTg>cGg	p.L731R	CMIP_ENST00000566513.1_3'UTR|CMIP_ENST00000398040.4_Missense_Mutation_p.L578R|CMIP_ENST00000539778.2_Missense_Mutation_p.L637R	NM_198390.2	NP_938204.2	Q8IY22	CMIP_HUMAN	c-Maf inducing protein	697						cytoplasm|nucleus				endometrium(5)|kidney(1)|lung(7)	13						CTGCTGGCCCTGAGCTGTGAG	0.622000													5	4					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	65016142	65016142	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:65016142G>A	ENST00000394156.3	-	8	1515	c.1062C>T	c.(1060-1062)atC>atT	p.I354I	CDH11_ENST00000566827.1_Silent_p.I228I|CDH11_ENST00000268603.4_Silent_p.I354I			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	354	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		ACTTCGGGTCGATGTGCACGT	0.468000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			41	27					0	0	1	0	0
VWA5A	4013	broad.mit.edu	37	11	124006999	124006999	+	Splice_Site	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:124006999C>A	ENST00000456829.2	+	13	1774	c.1524_splice	c.e13+1	p.P508_splice	VWA5A_ENST00000360334.4_Intron|VWA5A_ENST00000392748.1_Splice_Site_p.P508_splice	NM_001130142.1	NP_001123614.1	O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	508										autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						GGGAGGATGCCAGTGAGTTCC	0.483000													6	35					0.0293803	0.0296648	1	1	0
LMNB2	84823	broad.mit.edu	37	19	2434809	2434809	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:2434809G>A	ENST00000325327.3	-	6	1020	c.958C>T	c.(958-960)Cag>Tag	p.Q320*	LMNB2_ENST00000582871.1_Nonsense_Mutation_p.Q300*			Q03252	LMNB2_HUMAN	lamin B2	300	Coil 2.|Rod.					nuclear inner membrane	structural molecule activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGAGAGCTGGTAGCTGAGG	0.687000													10	18					0	0	1	0	0
AGAP3	116988	broad.mit.edu	37	7	150815625	150815625	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:150815625A>T	ENST00000397238.2	+	7	875	c.875A>T	c.(874-876)cAg>cTg	p.Q292L	AGAP3_ENST00000335367.3_Missense_Mutation_p.Q472L|AGAP3_ENST00000479901.1_Missense_Mutation_p.Q292L|AGAP3_ENST00000463381.1_Missense_Mutation_p.Q64L|AGAP3_ENST00000473312.1_Missense_Mutation_p.Q292L	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	256	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						CGAAAGAAGCAGCAACTGGCC	0.622000													67	74					0	0	1	0	0
KIAA1731	85459	broad.mit.edu	37	11	93454576	93454576	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:93454576A>G	ENST00000325212.6	+	19	6010	c.5848A>G	c.(5848-5850)Aag>Gag	p.K1950E	KIAA1731_ENST00000531700.1_Missense_Mutation_p.K130E|KIAA1731_ENST00000411936.1_Missense_Mutation_p.K1950E|KIAA1731_ENST00000344196.4_Missense_Mutation_p.K130E			Q9C0D2	K1731_HUMAN	KIAA1731	1950						centrosome				breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)	11		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GCCAGATGATAAGGTTAGTAA	0.353000													7	23					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149482236	149482236	+	RNA	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:149482236T>A	ENST00000378016.2	+	0	2910							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCTGTGTGCCTCCTGACCTCT	0.637000													53	59					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121293232	121293232	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:121293232C>T	ENST00000297848.3	+	31	4028	c.3758C>T	c.(3757-3759)cCt>cTt	p.P1253L	COL14A1_ENST00000247781.3_Missense_Mutation_p.P1158L|COL14A1_ENST00000309791.4_Missense_Mutation_p.P1253L	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1253	Nonhelical region (NC4).|TSP N-terminal.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TCTATGGAGCCTGGTACCTTC	0.358000													20	32					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P|FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													7	203					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158287446	158287446	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:158287446C>A	ENST00000264192.3	-	4	429	c.308G>T	c.(307-309)tGc>tTc	p.C103F	CYTIP_ENST00000540637.1_5'UTR|CYTIP_ENST00000497432.1_5'UTR	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	103	PDZ.				regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						TTCCGAGGAGCAGGCATTCTG	0.378000													7	13					0.00307968	0.0031709	1	1	0
CENPE	1062	broad.mit.edu	37	4	104066453	104066453	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:104066453T>C	ENST00000265148.3	-	32	4700	c.4611A>G	c.(4609-4611)atA>atG	p.I1537M	CENPE_ENST00000380026.3_Missense_Mutation_p.I1512M	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	1537					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TAATTTGTTTTATATTAAATT	0.294000													18	21					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48914996	48914996	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:48914996C>G	ENST00000294954.7	-	11	1961	c.1940G>C	c.(1939-1941)cGg>cCg	p.R647P	LHCGR_ENST00000401907.1_3'UTR|LHCGR_ENST00000344775.3_Missense_Mutation_p.R585P|STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000405626.1_Missense_Mutation_p.R620P|LHCGR_ENST00000403273.1_3'UTR	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	647					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	AAGTTCAGCCCGACGTTTACA	0.383000													52	114					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128782056	128782056	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:128782056G>A	ENST00000529694.1	+	2	1264	c.888G>A	c.(886-888)caG>caA	p.Q296Q	KCNJ5_ENST00000533599.1_Silent_p.Q296Q|KCNJ5_ENST00000338350.4_Silent_p.Q296Q	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	296					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	AGCTGCATCAGGAAGAGTTTG	0.542000													61	119					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79292142	79292142	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:79292142C>G	ENST00000419573.3	-	18	3011	c.2737G>C	c.(2737-2739)Gcc>Ccc	p.A913P	RASGRF1_ENST00000394745.3_Missense_Mutation_p.A129P|RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000558480.2_Missense_Mutation_p.A897P	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	915					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						CCCTCGTTGGCCCCGGCGGTT	0.572000													47	98					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77616489	77616489	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:77616489C>A	ENST00000521891.2	+	2	614	c.166C>A	c.(166-168)Cgc>Agc	p.R56S	ZFHX4_ENST00000455469.2_Missense_Mutation_p.R56S|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Missense_Mutation_p.R56S|ZFHX4_ENST00000050961.6_Missense_Mutation_p.R56S	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	56						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R56C(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AACGGATGAGCGCAAAAGTGA	0.498000										HNSCC(33;0.089)			46	61					2.24893e-16	2.93164e-16	1	1	0
DGKG	1608	broad.mit.edu	37	3	185882752	185882752	+	Silent	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:185882752C>G	ENST00000265022.3	-	23	2690	c.2151G>C	c.(2149-2151)ggG>ggC	p.G717G	DGKG_ENST00000447054.1_5'UTR|DGKG_ENST00000544847.1_Silent_p.G658G|DGKG_ENST00000344484.4_Silent_p.G692G|DGKG_ENST00000382164.4_Silent_p.G678G	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	717					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	TGTAGATCTGCCCCATCTCCA	0.562000													54	88					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128890738	128890738	+	Silent	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:128890738T>C	ENST00000375990.3	+	14	1732	c.1329T>C	c.(1327-1329)gaT>gaC	p.D443D	UGGT1_ENST00000259253.6_Silent_p.D467D			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	467					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TGGAGGTTGATAGCAGATATA	0.378000													77	128					0	0	1	0	0
CEP70	80321	broad.mit.edu	37	3	138218970	138218970	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:138218970C>A	ENST00000264982.3	-	16	1900	c.1634G>T	c.(1633-1635)gGa>gTa	p.G545V	CEP70_ENST00000542237.1_Missense_Mutation_p.G525V|CEP70_ENST00000489254.1_Missense_Mutation_p.G393V|CEP70_ENST00000481834.1_Missense_Mutation_p.G545V|CEP70_ENST00000484888.1_Missense_Mutation_p.G545V	NM_024491.2	NP_077817.2	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70kDa	545					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	24						GTCTTCAGGTCCTAATACCTG	0.443000													47	52					3.54909e-21	4.83365e-21	1	1	0
TRIM17	51127	broad.mit.edu	37	1	228602428	228602428	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:228602428G>T	ENST00000366697.2	-	1	1302	c.346C>A	c.(346-348)Ccc>Acc	p.P116T	TRIM17_ENST00000295033.3_Missense_Mutation_p.P116T|TRIM17_ENST00000366698.2_Missense_Mutation_p.P116T|TRIM17_ENST00000456946.2_Missense_Mutation_p.P116T			Q9Y577	TRI17_HUMAN	tripartite motif containing 17	116					protein autoubiquitination	intracellular	protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)	10		Prostate(94;0.0724)				ACACAGATGGGGCTCTGGTCC	0.657000													17	152					3.99206e-14	4.98154e-14	1	1	0
BTBD11	121551	broad.mit.edu	37	12	107937909	107937909	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:107937909G>T	ENST00000280758.5	+	3	2011	c.1483G>T	c.(1483-1485)Gtg>Ttg	p.V495L	BTBD11_ENST00000420571.2_Missense_Mutation_p.V495L|BTBD11_ENST00000490090.2_Missense_Mutation_p.V495L	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	495						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CAACCTCCAGGTGGAAAGGTA	0.567000													13	33					1.61879e-10	1.90908e-10	1	1	0
PYCRL	65263	broad.mit.edu	37	8	144687915	144687915	+	Silent	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:144687915G>C	ENST00000220966.6	-	6	845	c.816C>G	c.(814-816)gcC>gcG	p.A272A	PYCRL_ENST00000377579.3_Silent_p.A123A|PYCRL_ENST00000495276.1_5'UTR	NM_023078.3	NP_075566.2	Q53H96	P5CR3_HUMAN	pyrroline-5-carboxylate reductase-like	260					proline biosynthetic process		pyrroline-5-carboxylate reductase activity			central_nervous_system(1)|endometrium(1)|lung(2)|ovary(1)	5	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CAGCCTCCACGGCGCTCATGG	0.682000													9	71					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580934	140580934	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:140580934C>A	ENST00000354757.3	+	1	1587	c.1587C>A	c.(1585-1587)ttC>ttA	p.F529L	PCDHB11_ENST00000536699.1_Missense_Mutation_p.F164L	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		529	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTTCGACTTCCGCGTGGGCG	0.672000													117	64					4.73232e-52	7.07909e-52	1	1	0
HECTD2	143279	broad.mit.edu	37	10	93221098	93221098	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:93221098A>C	ENST00000446394.1	+	4	595	c.495A>C	c.(493-495)ttA>ttC	p.L165F	HECTD2_ENST00000298068.5_Missense_Mutation_p.L165F|HECTD2_ENST00000371681.4_Missense_Mutation_p.L165F			Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	165					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						TCCCAGAATTAAATGCTGCAT	0.279000													40	39					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5776249	5776249	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:5776249C>A	ENST00000381624.3	+	21	2080	c.2019C>A	c.(2017-2019)ggC>ggA	p.G673G	CATSPERD_ENST00000309164.7_3'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	673						integral to membrane											TCTTGGGCGGCCGGACAGCAA	0.542000													42	67					7.63091e-17	1.0001e-16	1	1	0
FRG1BP	284802	broad.mit.edu	37	20	29631619	29631619	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:29631619A>T	ENST00000278882.3	+	7	795	c.415A>T	c.(415-417)Atc>Ttc	p.I139F	FRG1B_ENST00000358464.4_Missense_Mutation_p.I139F																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ACAATGTGAAATCAATTATGT	0.328000													18	20					0	0	1	0	0
AK9	221264	broad.mit.edu	37	6	109995439	109995439	+	Missense_Mutation	SNP	C	C	T	rs150756404	byFrequency	TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:109995439C>T	ENST00000424296.2	-	3	219	c.143G>A	c.(142-144)cGt>cAt	p.R48H	AK9_ENST00000285397.5_Missense_Mutation_p.R48H|AK9_ENST00000341338.6_5'UTR|AK9_ENST00000368948.2_Missense_Mutation_p.R48H	NM_001145128.2	NP_001138600.2			adenylate kinase 9																		TGTTATGTAACGGGCTAATGT	0.294000													3	33					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101588880	101588880	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:101588880C>T	ENST00000536262.2	-	4	1088	c.530G>A	c.(529-531)tGc>tAc	p.C177Y		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	177					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TACCAGTGTGCAGTAGAATGT	0.418000													16	19					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35733883	35733883	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr13:35733883G>C	ENST00000540320.1	+	22	4109	c.3575G>C	c.(3574-3576)gGt>gCt	p.G1192A	NBEA_ENST00000310336.4_Missense_Mutation_p.G1192A|NBEA_ENST00000400445.3_Missense_Mutation_p.G1192A|NBEA_ENST00000379939.2_Missense_Mutation_p.G1192A			Q8NFP9	NBEA_HUMAN	neurobeachin	1192						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CACATGACCGGTAGCGTAGAC	0.363000													12	15					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208747	58208747	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr13:58208747C>A	ENST00000377918.3	+	1	2093	c.2067C>A	c.(2065-2067)ccC>ccA	p.P689P		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	689	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GATCCCTTCCCGAGGGGGTAC	0.637000													54	75					1.00221e-16	1.31114e-16	1	1	0
MYH13	8735	broad.mit.edu	37	17	10227485	10227485	+	Silent	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:10227485A>G	ENST00000418404.3	-	22	2951	c.2788T>C	c.(2788-2790)Ttg>Ctg	p.L930L	MYH13_ENST00000570743.1_Silent_p.L930L|RP11-401O9.3_ENST00000577743.1_RNA|MYH13_ENST00000252172.4_Silent_p.L930L			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	930					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TCCTCTTCCAATCTCTCCGTC	0.453000													85	24					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47681656	47681656	+	Silent	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:47681656C>A	ENST00000283303.2	+	6	933	c.675C>A	c.(673-675)ctC>ctA	p.L225L	GPR115_ENST00000371220.1_Silent_p.L282L|GPR115_ENST00000327753.3_Silent_p.L225L	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	225					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						CCAGACAACTCCACATCCACA	0.408000													37	83					3.3946e-10	3.97762e-10	1	1	0
ERCC6	2074	broad.mit.edu	37	10	50690871	50690871	+	Silent	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:50690871C>G	ENST00000355832.5	-	10	2109	c.2031G>C	c.(2029-2031)ccG>ccC	p.P677P	ERCC6_ENST00000542458.1_Silent_p.P47P	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	677	Helicase ATP-binding.				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TATTTTGCATCGGTGAGCCAG	0.473000								Direct reversal of damage;Nucleotide excision repair (NER)					33	39					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7064078	7064078	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:7064078C>A	ENST00000299481.4	+	4	1167	c.821C>A	c.(820-822)gCa>gAa	p.A274E		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	274	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CCTGAGTTTGCACTGTGCGAA	0.458000													53	33					6.4308e-24	8.97607e-24	1	1	0
PTPRD	5789	broad.mit.edu	37	9	8341964	8341964	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:8341964C>G	ENST00000381196.4	-	37	5219	c.4676G>C	c.(4675-4677)cGg>cCg	p.R1559P	PTPRD_ENST00000356435.5_Missense_Mutation_p.R1559P|PTPRD_ENST00000540109.1_Missense_Mutation_p.R1559P|PTPRD_ENST00000355233.5_Missense_Mutation_p.R1153P|PTPRD_ENST00000537002.1_Missense_Mutation_p.R1149P|PTPRD_ENST00000486161.1_Missense_Mutation_p.R1152P|PTPRD_ENST00000397617.3_Missense_Mutation_p.R1152P|PTPRD_ENST00000397606.3_Missense_Mutation_p.R1152P|PTPRD_ENST00000360074.4_Missense_Mutation_p.R1546P|PTPRD_ENST00000358503.5_Missense_Mutation_p.R1537P|PTPRD_ENST00000397611.3_Missense_Mutation_p.R1149P	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1559	Substrate binding (By similarity).|Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCAACCAGTCCGGCCAACTCC	0.343000										TSP Lung(15;0.13)			28	22					0	0	1	0	0
SLC22A2	6582	broad.mit.edu	37	6	160670390	160670390	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:160670390G>T	ENST00000366952.1	-	6	2118	c.637C>A	c.(637-639)Cgg>Agg	p.R213R	SLC22A2_ENST00000366953.3_Silent_p.R234R|SLC22A2_ENST00000491092.1_5'UTR			O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	234					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		ACTGTTCTCCGATATCTCCGC	0.458000													46	109					2.69774e-35	3.97849e-35	1	1	0
SMC1B	27127	broad.mit.edu	37	22	45758803	45758803	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr22:45758803T>G	ENST00000357450.4	-	16	2523	c.2524A>C	c.(2524-2526)Atc>Ctc	p.I842L	SMC1B_ENST00000404354.3_Missense_Mutation_p.I842L	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	842					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCTTTCTGGATAGTTTCTTTT	0.333000													23	19					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139706751	139706751	+	Splice_Site	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:139706751C>A	ENST00000303045.6	-	34	3146	c.2700_splice	c.e34+1	p.P900_splice	COL22A1_ENST00000435777.1_Splice_Site_p.P900_splice|COL22A1_ENST00000341807.4_5'UTR	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	900	Collagen-like 7.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GTTTTCTTACCGGTGGTCCAG	0.597000										HNSCC(7;0.00092)			43	60					8.20599e-20	1.10933e-19	1	1	0
SCN9A	6335	broad.mit.edu	37	2	167089972	167089972	+	Splice_Site	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:167089972C>T	ENST00000375387.4	-	21	4145	c.3804_splice	c.e21-1	p.V1269_splice	SCN9A_ENST00000409435.1_Splice_Site_p.V1268_splice|SCN9A_ENST00000303354.6_Splice_Site_p.V1269_splice|SCN9A_ENST00000409672.1_Splice_Site_p.V1257_splice|AC010127.3_ENST00000447809.2_RNA			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1268						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	ACCAAAGAAACCTATAAAAAT	0.358000													11	15					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12956894	12956894	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:12956894C>A	ENST00000276297.4	-	9	3361	c.2952G>T	c.(2950-2952)agG>agT	p.R984S	DLC1_ENST00000358919.2_Missense_Mutation_p.R547S|DLC1_ENST00000512044.2_Missense_Mutation_p.R581S|DLC1_ENST00000520226.1_Missense_Mutation_p.R473S	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	984					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CCCCAGAATCCCTTCTTTCCG	0.582000													34	28					4.3181e-19	5.79451e-19	1	1	0
KCNT2	343450	broad.mit.edu	37	1	196397339	196397339	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:196397339G>T	ENST00000367433.5	-	10	981	c.880C>A	c.(880-882)Cat>Aat	p.H294N	KCNT2_ENST00000367431.4_Missense_Mutation_p.H294N|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_Intron|KCNT2_ENST00000294725.8_Missense_Mutation_p.H294N			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	294						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TGAGCTCTATGTCGACTATAG	0.368000													48	29					1.22102e-19	1.64758e-19	1	1	0
IMPG2	50939	broad.mit.edu	37	3	100961570	100961570	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:100961570T>C	ENST00000193391.7	-	14	3171	c.2984A>G	c.(2983-2985)aAc>aGc	p.N995S		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	995	SEA 2.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						AATAGCCAAGTTCATGGTATT	0.393000													23	99					0	0	1	0	0
ZNF202	7753	broad.mit.edu	37	11	123601242	123601242	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:123601242T>C	ENST00000336139.4	-	3	717	c.355A>G	c.(355-357)Acg>Gcg	p.T119A	ZNF202_ENST00000530393.1_Missense_Mutation_p.T119A|ZNF202_ENST00000529691.1_Missense_Mutation_p.T119A			O95125	ZN202_HUMAN	zinc finger protein 202	119	SCAN box.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		TCCACCAGCGTCACTGCCTCC	0.582000													18	141					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70926676	70926676	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:70926676A>T	ENST00000357250.6	-	38	2848	c.2690T>A	c.(2689-2691)cTt>cAt	p.L897H	COL9A1_ENST00000370499.4_Missense_Mutation_p.L654H|COL9A1_ENST00000320755.7_Missense_Mutation_p.L654H|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	897	Triple-helical region (COL1).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						GAAACCGGGAAGCCCAGGAGG	0.632000													26	44					0	0	1	0	0
TBC1D24	57465	broad.mit.edu	37	16	2550805	2550805	+	Splice_Site	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:2550805G>T	ENST00000567020.1	+	7	1648	c.1507_splice	c.e7-1	p.G503_splice	RP11-20I23.1_ENST00000564543.1_Intron|TBC1D24_ENST00000434757.2_Splice_Site_p.G509_splice|TBC1D24_ENST00000293970.5_Splice_Site_p.G509_splice	NM_020705.2	NP_065756.1	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	509	TLD.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)	13						CATCCTGCAGGGGGAGGAGGC	0.662000													5	25					5.9392e-07	6.57908e-07	1	1	0
CATSPERD	257062	broad.mit.edu	37	19	5772918	5772918	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:5772918C>T	ENST00000381624.3	+	20	1944	c.1883C>T	c.(1882-1884)cCg>cTg	p.P628L	CATSPERD_ENST00000309164.7_3'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	628						integral to membrane											ACCTCCCAGCCGCAGAACTGG	0.557000													38	65					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72154044	72154044	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:72154044C>T	ENST00000355636.6	-	20	2951	c.2338G>A	c.(2338-2340)Gaa>Aaa	p.E780K	PMFBP1_ENST00000237353.10_Intron|PMFBP1_ENST00000537465.1_Intron|PMFBP1_ENST00000537792.1_Intron	NM_001160213.1	NP_001153685.1	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	928										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				CTGGTTGGTTCCCTGCTAGAA	0.532000													55	37					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48586068	48586068	+	Silent	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:48586068A>G	ENST00000323776.5	+	1	324	c.162A>G	c.(160-162)agA>agG	p.R54R	MYCBPAP_ENST00000436259.2_Silent_p.R17R|MYCBPAP_ENST00000419930.1_Silent_p.R54R	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	17					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CCCGCCTCAGAATAACTCCGA	0.622000													11	8					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26112196	26112196	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr13:26112196C>T	ENST00000381655.2	+	7	720	c.578C>T	c.(577-579)tCc>tTc	p.S193F	ATP8A2_ENST00000255283.8_Missense_Mutation_p.S153F	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	153					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		CTGCTGTCATCCAGGTTAGCT	0.493000													20	19					0	0	1	0	0
USP38	84640	broad.mit.edu	37	4	144135059	144135059	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:144135059G>T	ENST00000307017.4	+	9	2436	c.1930G>T	c.(1930-1932)Ggt>Tgt	p.G644C	USP38_ENST00000510377.1_Missense_Mutation_p.G644C	NM_032557.5	NP_115946.2	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	644					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	33	all_hematologic(180;0.158)					ACAAGATGGTGGTCTAATGCA	0.438000													109	218					8.11351e-46	1.20875e-45	1	1	0
TUBBP5	643224	broad.mit.edu	37	9	141070116	141070116	+	RNA	SNP	G	G	A	rs142836124	by1000genomes	TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:141070116G>A	ENST00000503395.1	+	0	1196																		p.R77H(1)									GACTCTGTGCGCTCGGGGCCC	0.687000													8	86					0	0	1	0	0
IFRD1	3475	broad.mit.edu	37	7	112102225	112102225	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:112102225A>T	ENST00000403825.3	+	7	1049	c.788A>T	c.(787-789)aAg>aTg	p.K263M	IFRD1_ENST00000535603.1_Missense_Mutation_p.K213M|IFRD1_ENST00000005558.4_Missense_Mutation_p.K263M	NM_001550.3	NP_001541.2	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	263					multicellular organismal development|myoblast cell fate determination		binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|urinary_tract(1)	15						GTGAAGAAAAAGCTTGAGATG	0.333000													13	34					0	0	1	0	0
FAM66D	100132923	broad.mit.edu	37	8	11986694	11986694	+	RNA	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:11986694G>T	ENST00000434078.2	+	0	608					NR_027425.1																						TGACTTCTCAGGGAGAGAAGT	0.522000													41	199					6.86731e-36	1.0148e-35	1	1	0
ZC3H12C	85463	broad.mit.edu	37	11	110035858	110035858	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:110035858C>G	ENST00000453089.2	+	5	2836	c.1955C>G	c.(1954-1956)cCc>cGc	p.P652R	ZC3H12C_ENST00000278590.3_Missense_Mutation_p.P683R|ZC3H12C_ENST00000528673.1_Missense_Mutation_p.P684R			Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	683							endonuclease activity|nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		TTCCACGACCCCTTAACCAGA	0.557000													105	277					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226578208	226578208	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:226578208G>T	ENST00000366794.5	-	4	663	c.520C>A	c.(520-522)Ccc>Acc	p.P174T		NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	174					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		CTGTACTCGGGCCGGAAACCC	0.562000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					56	47					5.73376e-24	8.01847e-24	1	1	0
CBWD5	220869	broad.mit.edu	37	9	70490056	70490056	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:70490056C>T	ENST00000382405.3	-	1	190	c.13G>A	c.(13-15)Gtt>Att	p.V5I	CBWD5_ENST00000430059.2_Missense_Mutation_p.V5I|CBWD5_ENST00000377395.4_Missense_Mutation_p.V5I|CBWD5_ENST00000429800.2_Missense_Mutation_p.V5I|CBWD5_ENST00000377384.1_Missense_Mutation_p.V5I			Q5RIA9	CBWD5_HUMAN	COBW domain containing 5	5							ATP binding								all cancers(8;0.00136)|Epithelial(8;0.0288)|GBM - Glioblastoma multiforme(74;0.0402)|OV - Ovarian serous cystadenocarcinoma(323;0.18)		ACAGATCCAACAGCCGGTAAC	0.612000													56	113					0	0	1	0	0
OR2T2	401992	broad.mit.edu	37	1	248616210	248616210	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:248616210G>C	ENST00000342927.3	+	1	134	c.112G>C	c.(112-114)Gtg>Ctg	p.V38L		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CATCTTTGTGGTGGCTATAAC	0.527000													105	228					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79392735	79392735	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:79392735G>T	ENST00000370742.3	-	8	982	c.919C>A	c.(919-921)Cct>Act	p.P307T		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	307					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GAAAGCAAAGGACCAATACTC	0.294000													15	21					7.93312e-07	8.748e-07	1	1	0
OR9Q1	219956	broad.mit.edu	37	11	57947506	57947506	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:57947506T>A	ENST00000335397.3	+	3	906	c.590T>A	c.(589-591)gTg>gAg	p.V197E		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				ACTCAAGAAGTGCTGATTATT	0.463000													48	73					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21689222	21689222	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:21689222G>T	ENST00000398485.2	+	3	997	c.943G>T	c.(943-945)Gct>Tct	p.A315S	PAX1_ENST00000460221.1_3'UTR|PAX1_ENST00000444366.2_Missense_Mutation_p.A291S	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	315					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						CGAAGGCACCGCTTACTCTCC	0.627000													69	103					6.07461e-23	8.4466e-23	1	1	0
MATN1	4146	broad.mit.edu	37	1	31191603	31191603	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:31191603T>G	ENST00000373765.4	-	3	678	c.643A>C	c.(643-645)Aag>Cag	p.K215Q	MATN1_ENST00000477320.1_5'UTR|MATN1-AS1_ENST00000414532.2_RNA	NM_002379.3	NP_002370.1	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein	215	VWFA 1.				protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTGGAACTTCCTGGACAGC	0.706000													16	25					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119296323	119296323	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:119296323G>T	ENST00000338891.7	-	13	3077	c.2634C>A	c.(2632-2634)caC>caA	p.H878Q	FAM184A_ENST00000368475.4_Missense_Mutation_p.H758Q|RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000352896.5_Missense_Mutation_p.H758Q|FAM184A_ENST00000521531.1_Missense_Mutation_p.H878Q	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	878										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						GATGCTCTCTGTGTCTTAATT	0.338000													11	31					6.40141e-05	6.812e-05	1	1	0
CATSPERB	79820	broad.mit.edu	37	14	92088146	92088146	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:92088146T>A	ENST00000256343.3	-	19	2222	c.2066A>T	c.(2065-2067)aAc>aTc	p.N689I		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	689					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				GGTCATATTGTTGGGTGCACT	0.388000													37	60					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8670004	8670004	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:8670004C>G	ENST00000270328.4	-	3	594	c.328G>C	c.(328-330)Gag>Cag	p.E110Q	ADAMTS10_ENST00000596709.1_5'UTR|ADAMTS10_ENST00000597188.1_Missense_Mutation_p.E110Q			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	110					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GCCAGGCCCTCCCGTGTCCAG	0.677000													22	26					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89462292	89462292	+	Splice_Site	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:89462292A>T	ENST00000336596.2	+	10	1989	c.1762_splice	c.e10-1	p.L588_splice	EPHA3_ENST00000494014.1_Splice_Site_p.L588_splice	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	588						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CTCAAACAGTAAAACTTCCAG	0.373000										TSP Lung(6;0.00050)			44	76					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170063263	170063263	+	Silent	SNP	G	G	A	rs149367019	byFrequency	TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:170063263G>A	ENST00000263816.3	-	39	7252	c.6967C>T	c.(6967-6969)Cta>Tta	p.L2323L		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2323					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACATCTCTTAGCCAGTTGATA	0.463000													33	53					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585680	82585680	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:82585680C>A	ENST00000423517.2	-	5	4926	c.4589G>T	c.(4588-4590)aGa>aTa	p.R1530I	PCLO_ENST00000333891.8_Missense_Mutation_p.R1530I	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1461					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AACACTAGTTCTTCGTTTTCT	0.398000													15	36					7.93312e-07	8.748e-07	1	1	0
RNF40	9810	broad.mit.edu	37	16	30774800	30774800	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:30774800C>T	ENST00000324685.6	+	4	797	c.362C>T	c.(361-363)gCg>gTg	p.A121V	RNF40_ENST00000402121.3_Intron|RNF40_ENST00000563683.1_Missense_Mutation_p.A121V|RNF40_ENST00000357890.5_Missense_Mutation_p.A121V	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586.1	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	121					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			CTGTCTTCAGCGCCTGAGGCA	0.562000													4	157					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50111284	50111284	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:50111284G>C	ENST00000281631.5	+	15	1752	c.1594G>C	c.(1594-1596)Gag>Cag	p.E532Q	PARP8_ENST00000503750.2_Missense_Mutation_p.E532Q|PARP8_ENST00000514067.2_Missense_Mutation_p.E532Q|PARP8_ENST00000505697.2_Missense_Mutation_p.E532Q|PARP8_ENST00000514342.2_Missense_Mutation_p.E285Q|PARP8_ENST00000505554.1_Missense_Mutation_p.E511Q|PARP8_ENST00000511363.2_3'UTR	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	532						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				ATGTGAACGGGAGCTGTGTGT	0.353000													18	20					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129799951	129799951	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:129799951C>A	ENST00000421865.2	+	54	7614	c.7565C>A	c.(7564-7566)tCc>tAc	p.S2522Y		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2522					cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AAAGGATGTTCCCTGGAGGTT	0.378000													69	127					1.43161e-34	2.10277e-34	1	1	0
LILRA2	11027	broad.mit.edu	37	19	55087315	55087315	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:55087315C>T	ENST00000251377.3	+	7	1127	c.994C>T	c.(994-996)Ccc>Tcc	p.P332S	LILRA2_ENST00000391737.1_Missense_Mutation_p.P320S|LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000251376.3_Missense_Mutation_p.P332S|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391738.3_Missense_Mutation_p.P332S					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		GCAGCCGGTCCCCACAGTAGC	0.602000													26	32					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55972792	55972792	+	Silent	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:55972792A>T	ENST00000389286.4	-	5	758	c.711T>A	c.(709-711)atT>atA	p.I237I	RP11-420M1.2_ENST00000561155.1_RNA	NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	237	Ig-like 3.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		GACCTGCTATAATTGTTGGTG	0.368000													59	110					0	0	1	0	0
SNAP25	6616	broad.mit.edu	37	20	10286817	10286817	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:10286817G>A	ENST00000254976.2	+	8	804	c.593G>A	c.(592-594)cGt>cAt	p.R198H	SNAP25_ENST00000495883.1_3'UTR|SNAP25_ENST00000304886.2_Missense_Mutation_p.R198H|SNAP25-AS1_ENST00000421143.2_RNA|SNAP25-AS1_ENST00000453544.1_RNA	NM_130811.2	NP_570824.1	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	198	t-SNARE coiled-coil homology 2.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	GCCAACCAACGTGCAACAAAG	0.458000													10	28					0	0	1	0	0
U2AF1L4	199746	broad.mit.edu	37	19	36234912	36234912	+	Splice_Site	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:36234912C>T	ENST00000412391.2	-	6	496		c.e6+1		U2AF1L4_ENST00000292879.5_Intron|U2AF1L4_ENST00000378975.3_Splice_Site|AD000671.6_ENST00000589807.1_Intron			Q8WU68	U2AF4_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 4						mRNA processing|RNA splicing	nuclear speck|spliceosomal complex	nucleotide binding|RNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)	8	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AACTACCATACCCCATCTCAT	0.552000													18	65					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129558510	129558510	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr12:129558510C>T	ENST00000422113.2	-	9	3536	c.3210G>A	c.(3208-3210)gaG>gaA	p.E1070E	TMEM132D_ENST00000389441.4_Silent_p.E608E	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	1070						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TAATGTCATCCTCGCTACTCA	0.507000													43	92					0	0	1	0	0
CNKSR1	10256	broad.mit.edu	37	1	26504062	26504062	+	Silent	SNP	C	C	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:26504062C>G	ENST00000361530.6	+	1	169	c.24C>G	c.(22-24)acC>acG	p.T8T	CNKSR1_ENST00000480348.2_3'UTR|CNKSR1_ENST00000374253.5_Silent_p.T8T			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	8	SAM.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		AGACCTGGACCCCCGGAAAGG	0.637000													10	50					0	0	1	0	0
NEUROD1	4760	broad.mit.edu	37	2	182543549	182543549	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:182543549C>T	ENST00000295108.3	-	2	496	c.39G>A	c.(37-39)gaG>gaA	p.E13E	NEUROD1_ENST00000496876.1_Intron|CERKL_ENST00000479558.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	13					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			GGGGCTGAGGCTCGCCCATCA	0.517000													5	55					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54969305	54969305	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:54969305G>T	ENST00000326764.5	+	14	2405	c.1926G>T	c.(1924-1926)caG>caT	p.Q642H	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	605							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		AGTTTAACCAGTGCCAGACGC	0.572000													39	57					1.96642e-18	2.6195e-18	1	1	0
HTATIP2	10553	broad.mit.edu	37	11	20403774	20403774	+	Silent	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:20403774A>G	ENST00000451739.2	+	4	933	c.492A>G	c.(490-492)gtA>gtG	p.V164V	HTATIP2_ENST00000419348.2_Silent_p.V198V|HTATIP2_ENST00000531058.1_Silent_p.V118V|HTATIP2_ENST00000421577.2_Silent_p.V164V|HTATIP2_ENST00000443524.2_Silent_p.V164V	NM_001098522.1	NP_001091992.1	Q9BUP3	HTAI2_HUMAN	HIV-1 Tat interactive protein 2, 30kDa	164					angiogenesis|anti-apoptosis|apoptosis|cell differentiation|cellular amino acid metabolic process|induction of apoptosis|interspecies interaction between organisms|nuclear import|regulation of angiogenesis|regulation of transcription from RNA polymerase II promoter	cytoplasm|nuclear envelope	NAD binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|protein binding|transcription coactivator activity			large_intestine(2)|lung(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						GTTACTCTGTATTTAGGCCTG	0.358000													22	9					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100683806	100683806	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:100683806C>T	ENST00000306151.4	+	3	9173	c.9109C>T	c.(9109-9111)Cca>Tca	p.P3037S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3037	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TACCGGCATACCAATCTCAAC	0.512000													261	355					0	0	1	0	0
CIAO1	9391	broad.mit.edu	37	2	96936884	96936884	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:96936884G>T	ENST00000488633.1	+	7	1034	c.815G>T	c.(814-816)gGg>gTg	p.G272V		NM_004804.2	NP_004795.1	O76071	CIAO1_HUMAN	cytosolic iron-sulfur protein assembly 1	272					chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding			endometrium(1)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	5						ACAGCTTGTGGGGATGACGCG	0.562000													32	58					9.65963e-10	1.11575e-09	1	1	0
NKX2-1	7080	broad.mit.edu	37	14	36989271	36989271	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:36989271G>A	ENST00000354822.5	-	1	162	c.64C>T	c.(64-66)Ccc>Tcc	p.P22S	NKX2-1_ENST00000518149.1_Intron|NKX2-1_ENST00000522719.2_5'UTR|NKX2-1-AS1_ENST00000521292.2_RNA	NM_001079668.2	NP_001073136.1	P43699	NKX21_HUMAN	NK2 homeobox 1	242					epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	7	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)		AGCCTGCCGGGGCTGCTCCTC	0.687000			A		NSCLC								17	28					0	0	1	0	0
MPPED1	758	broad.mit.edu	37	22	43830954	43830954	+	Splice_Site	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr22:43830954G>T	ENST00000417669.1	+	3	669	c.224_splice	c.e3-1	p.M75_splice	MPPED1_ENST00000414469.2_5'UTR|MPPED1_ENST00000439548.1_Intron|MPPED1_ENST00000542779.1_Splice_Site_p.M75_splice|MPPED1_ENST00000538182.1_Splice_Site_p.M108_splice|MPPED1_ENST00000443721.1_Splice_Site_p.M75_splice			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	75							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				CTCCCTGCAGGGTGGACCCGG	0.647000													33	107					1.26612e-14	1.59908e-14	1	1	0
UGT2B15	7366	broad.mit.edu	37	4	69536139	69536139	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:69536139G>A	ENST00000338206.5	-	1	207	c.198C>T	c.(196-198)gcC>gcT	p.A66A		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	66					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										ATGATTTACTGGCATTGACAA	0.358000													107	231					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35065774	35065774	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:35065774G>T	ENST00000382002.5	-	10	1712	c.1286C>A	c.(1285-1287)tCt>tAt	p.S429Y	PRLR_ENST00000397391.3_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000310101.5_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.S328Y|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000513753.1_Intron|PRLR_ENST00000511486.1_Missense_Mutation_p.S328Y|PRLR_ENST00000231423.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	429					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	ATTGTGGTAAGAGGATCTGGG	0.493000													28	230					1.13719e-10	1.34764e-10	1	1	0
PDGFRA	5156	broad.mit.edu	37	4	55140745	55140745	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:55140745G>A	ENST00000257290.5	+	11	1937	c.1606G>A	c.(1606-1608)Gtg>Atg	p.V536M	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	536					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GGTGCTGTTGGTGATTGTGAT	0.443000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			33	82					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50053214	50053214	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:50053214A>G	ENST00000376042.1	+	6	2343	c.2045A>G	c.(2044-2046)cAt>cGt	p.H682R	CCNB3_ENST00000348603.2_Intron|CCNB3_ENST00000276014.7_Missense_Mutation_p.H682R|CCNB3_ENST00000376038.1_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	682					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					CATGTTAAGCATACCAACAAA	0.468000													16	10					0	0	1	0	0
SLC30A10	55532	broad.mit.edu	37	1	220091721	220091721	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:220091721G>T	ENST00000366926.3	-	3	995	c.834C>A	c.(832-834)taC>taA	p.Y278*	SLC30A10_ENST00000484079.1_5'UTR|SLC30A10_ENST00000536446.1_Nonsense_Mutation_p.Y33*	NM_018713.2	NP_061183.2	Q6XR72	ZNT10_HUMAN	solute carrier family 30, member 10	278					zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	13				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		TGGGGTCAATGTAACACTGCC	0.527000													22	141					5.26018e-13	6.42129e-13	1	1	0
KCTD8	386617	broad.mit.edu	37	4	44450171	44450171	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:44450171A>T	ENST00000360029.3	-	1	653	c.370T>A	c.(370-372)Ttc>Atc	p.F124I		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	124						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						TTCTCGGGGAAGTGCTCCGGC	0.612000										HNSCC(17;0.042)			22	16					0	0	1	0	0
E4F1	1877	broad.mit.edu	37	16	2282198	2282198	+	Missense_Mutation	SNP	G	G	A	rs143442513		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:2282198G>A	ENST00000301727.4	+	4	490	c.442G>A	c.(442-444)Gtg>Atg	p.V148M	E4F1_ENST00000564139.1_Missense_Mutation_p.V148M|E4F1_ENST00000565090.1_Missense_Mutation_p.V148M	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	148					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						AGAGGTCATCGTGGCTGCTGA	0.692000													7	194					0	0	1	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77510209	77510209	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:77510209G>T	ENST00000477717.1	+	3	817	c.582G>T	c.(580-582)caG>caT	p.Q194H		NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	194					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						TCCTGAGCCAGGTGCTGCCCC	0.582000													47	134					2.24722e-20	3.05488e-20	1	1	0
KRT32	3882	broad.mit.edu	37	17	39620373	39620373	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:39620373G>T	ENST00000225899.3	-	5	1056	c.953C>A	c.(952-954)aCg>aAg	p.T318K		NM_002278.3	NP_002269.3	Q14532	K1H2_HUMAN	keratin 32	318	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(137;0.000812)				CGTGTTGACCGTGCGTCTCAG	0.587000													23	67					9.95505e-16	1.28169e-15	1	1	0
ZCCHC7	84186	broad.mit.edu	37	9	37357174	37357174	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:37357174A>G	ENST00000336755.5	+	9	1647	c.1541A>G	c.(1540-1542)aAg>aGg	p.K514R	ZCCHC7_ENST00000461038.1_3'UTR|ZCCHC7_ENST00000534928.1_Missense_Mutation_p.K224R	NM_032226.2	NP_115602.2	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	514							nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	30				GBM - Glioblastoma multiforme(29;0.0137)		AAGGAAGGCAAGAGGGGCAAG	0.433000													31	57					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88327881	88327881	+	Missense_Mutation	SNP	C	C	T	rs149899708		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr13:88327881C>T	ENST00000325089.6	+	2	457	c.238C>T	c.(238-240)Cgt>Tgt	p.R80C	SLITRK5_ENST00000400028.3_Intron	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	80						integral to membrane		p.R80S(1)		breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TAGCCCTCCCCGTTTCCCAAT	0.458000													85	155					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57252860	57252860	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:57252860A>C	ENST00000343433.6	-	4	1021	c.941T>G	c.(940-942)cTg>cGg	p.L314R	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	314										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						CTCTGGAGACAGGGAGCCCTC	0.488000													27	75					0	0	1	0	0
PPIAL4G	644591	broad.mit.edu	37	1	143767832	143767832	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:143767832A>G	ENST00000419275.1	-	1	49	c.17T>C	c.(16-18)aTc>aCc	p.I6T		NM_001123068.1	NP_001116540.1	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like 4G	6				I -> V (in Ref. 2; AAI30379/AAI30377).	protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(2)|kidney(1)|lung(8)|ovary(1)|skin(1)	14						GTCAAAAAAGATGACGGAGTT	0.478000													5	181					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175898404	175898404	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr4:175898404C>A	ENST00000359240.3	+	5	2398	c.1728C>A	c.(1726-1728)ttC>ttA	p.F576L	ADAM29_ENST00000514159.1_Missense_Mutation_p.F576L|ADAM29_ENST00000445694.1_Missense_Mutation_p.F576L|ADAM29_ENST00000404450.4_Missense_Mutation_p.F576L	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	576	Cys-rich.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GGGCTCGCTTCAATGACATAA	0.408000													71	56					2.94884e-30	4.2375e-30	1	1	0
ZNF551	90233	broad.mit.edu	37	19	58199496	58199496	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:58199496G>A	ENST00000282296.5	+	3	2038	c.1853G>A	c.(1852-1854)aGt>aAt	p.S618N	ZNF551_ENST00000356715.4_Missense_Mutation_p.S602N|AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000596085.1_Intron	NM_001270938.1	NP_001257867.1	Q7Z340	ZN551_HUMAN	zinc finger protein 551	618					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TATGAGTGCAGTCAATGTGGG	0.453000													69	85					0	0	1	0	0
STARD7	56910	broad.mit.edu	37	2	96858995	96858995	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:96858995C>T	ENST00000337288.5	-	4	1028	c.645G>A	c.(643-645)tgG>tgA	p.W215*	STARD7_ENST00000462501.1_Intron	NM_020151.3	NP_064536.2	Q9NQZ5	STAR7_HUMAN	StAR-related lipid transfer (START) domain containing 7	215	START.					mitochondrion				endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|stomach(2)	14						AATGGGTTACCCAGTGAAGAA	0.428000													60	74					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82544969	82544969	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:82544969C>A	ENST00000423517.2	-	7	12670	c.12333G>T	c.(12331-12333)gaG>gaT	p.E4111D	PCLO_ENST00000437081.1_Missense_Mutation_p.E831D|PCLO_ENST00000333891.8_Missense_Mutation_p.E4111D	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4042					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTGGGTCTTCCTCCGCCTTCA	0.463000													7	30					1.06961e-07	1.19574e-07	1	1	0
CAMTA2	23125	broad.mit.edu	37	17	4883494	4883494	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr17:4883494A>C	ENST00000361571.5	-	8	1531	c.1120T>G	c.(1120-1122)Ttt>Gtt	p.F374V	CAMTA2_ENST00000572543.1_Missense_Mutation_p.F380V|CAMTA2_ENST00000348066.3_Missense_Mutation_p.F375V|CAMTA2_ENST00000381311.5_Missense_Mutation_p.F377V|CAMTA2_ENST00000358183.4_Missense_Mutation_p.F375V|CAMTA2_ENST00000414043.3_Missense_Mutation_p.F398V	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	375					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						TCAGGGTCAAAGGCAGGACTG	0.607000													57	50					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108788584	108788584	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:108788584A>T	ENST00000232603.5	-	9	792	c.710T>A	c.(709-711)tTc>tAc	p.F237Y	MORC1_ENST00000483760.1_Missense_Mutation_p.F237Y	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	237					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						GTAGGCTCTGAATGACCACCT	0.363000													11	46					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102130436	102130436	+	Silent	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:102130436T>A	ENST00000369138.1	+	5	1222	c.732T>A	c.(730-732)gcT>gcA	p.A244A	GRIK2_ENST00000369134.4_Silent_p.A195A|GRIK2_ENST00000318991.6_Silent_p.A244A|GRIK2_ENST00000421544.1_Silent_p.A244A|GRIK2_ENST00000369137.3_Silent_p.A244A|GRIK2_ENST00000413795.1_Silent_p.A244A|GRIK2_ENST00000358361.3_Silent_p.A244A	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	244					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	AGGCATTAGCTATGGGAATGA	0.289000													16	37					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12957281	12957281	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:12957281G>T	ENST00000276297.4	-	9	2974	c.2565C>A	c.(2563-2565)aaC>aaA	p.N855K	DLC1_ENST00000358919.2_Missense_Mutation_p.N418K|DLC1_ENST00000512044.2_Missense_Mutation_p.N452K|DLC1_ENST00000520226.1_Missense_Mutation_p.N344K	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	855					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						TGTCGCTACTGTTTTCCCTCC	0.582000													24	34					1.96895e-08	2.22153e-08	1	1	0
PRDM9	56979	broad.mit.edu	37	5	23509171	23509171	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:23509171G>T	ENST00000296682.3	+	2	211	c.29G>T	c.(28-30)aGc>aTc	p.S10I		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	10					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CAAGAGGAGAGCCCAGAAGAA	0.562000										HNSCC(3;0.000094)			19	24					3.51602e-12	4.25654e-12	1	1	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862813	10862813	+	RNA	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr21:10862813G>T	ENST00000559480.1	+	0	109																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						TGGGGCCTCAGTGAAGGTCTC	0.562000													40	270					5.7616e-29	8.23086e-29	1	1	0
LRRC37A6P	387646	broad.mit.edu	37	10	27535632	27535632	+	RNA	SNP	A	A	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:27535632A>G	ENST00000574842.1	+	0	255																											TCCATCTTCAAGGTCCGGATA	0.502000													81	182					0	0	1	0	0
NSUN2	54888	broad.mit.edu	37	5	6625745	6625745	+	Silent	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:6625745G>T	ENST00000264670.6	-	4	708	c.397C>A	c.(397-399)Cga>Aga	p.R133R	NSUN2_ENST00000505264.1_5'UTR|NSUN2_ENST00000539938.1_5'UTR|NSUN2_ENST00000506139.1_Silent_p.R98R	NM_017755.5	NP_060225.4	Q08J23	NSUN2_HUMAN	NOP2/Sun RNA methyltransferase family, member 2	133						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						AAGATTTTTCGACTTAAATTT	0.343000													34	20					2.5098e-30	3.61372e-30	1	1	0
ZNF560	147741	broad.mit.edu	37	19	9578249	9578249	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:9578249C>T	ENST00000301480.4	-	10	1587	c.1374G>A	c.(1372-1374)aaG>aaA	p.K458K		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	458					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						GCTCATATGGCTTCTCTCCAT	0.413000													77	146					0	0	1	0	0
ARMC6	93436	broad.mit.edu	37	19	19166153	19166153	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:19166153G>T	ENST00000535612.1	+	7	1535	c.1103G>T	c.(1102-1104)gGt>gTt	p.G368V	ARMC6_ENST00000392335.2_Missense_Mutation_p.G343V|ARMC6_ENST00000269932.6_Missense_Mutation_p.G343V|ARMC6_ENST00000392336.3_Missense_Mutation_p.G368V|ARMC6_ENST00000546344.1_Missense_Mutation_p.G275V	NM_001199196.1	NP_001186125.1	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	368							protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|prostate(1)	14			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			GTCCGTGCTGGTGGGACGGAG	0.627000													40	70					6.5261e-18	8.61493e-18	1	1	0
SYTL5	94122	broad.mit.edu	37	X	37985955	37985955	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:37985955G>A	ENST00000357972.5	+	17	2711	c.2165G>A	c.(2164-2166)cGt>cAt	p.R722H	SYTL5_ENST00000456733.2_Missense_Mutation_p.R744H|SYTL5_ENST00000297875.2_Missense_Mutation_p.R722H|TM4SF2_ENST00000465127.1_Intron			Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5	722					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	44						CTCATGCTTCGTTCCAGCATG	0.512000													11	12					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137255999	137255999	+	Silent	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:137255999T>A	ENST00000453654.1	-	19	1508	c.969A>T	c.(967-969)ccA>ccT	p.P323P	DGKI_ENST00000446122.1_Silent_p.P623P|DGKI_ENST00000424189.2_Silent_p.P623P|DGKI_ENST00000288490.5_Silent_p.P623P			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	623					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						GGTGATCACCTGGGTTTCCCC	0.408000													6	23					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22939269	22939269	+	Nonsense_Mutation	SNP	C	C	A	rs74170734		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:22939269C>A	ENST00000397104.3	-	7	2901	c.2902G>T	c.(2902-2904)Gga>Tga	p.G968*						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GGTTTCTTTCCAGTATGAATT	0.358000													15	32					0.00316338	0.00325249	1	1	0
PEG3	5178	broad.mit.edu	37	19	57327373	57327373	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:57327373T>C	ENST00000326441.9	-	10	2800	c.2437A>G	c.(2437-2439)Atc>Gtc	p.I813V	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.I689V|PEG3_ENST00000423103.2_Missense_Mutation_p.I813V|PEG3_ENST00000593695.1_Missense_Mutation_p.I687V|ZIM2_ENST00000599935.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	813					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGATGGTTGATAGCATCGAAG	0.473000													71	97					0	0	1	0	0
NCOA5	57727	broad.mit.edu	37	20	44690980	44690980	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr20:44690980G>A	ENST00000290231.6	-	8	1863	c.1699C>T	c.(1699-1701)Cag>Tag	p.Q567*		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	567	Transcription activation.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				GCCTGTGGCTGCCCCATCTGT	0.552000													4	53					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131815313	131815313	+	Silent	SNP	G	G	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:131815313G>A	ENST00000359827.3	-	32	6572	c.5610C>T	c.(5608-5610)caC>caT	p.H1870H	PLXNA4_ENST00000321063.4_Silent_p.H1870H			Q9HCM2	PLXA4_HUMAN	plexin A4	1870						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						ACTGGTCATCGTGGTCCAGAG	0.527000													16	52					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65266592	65266592	+	RNA	SNP	T	T	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:65266592T>A	ENST00000534336.1	+	0	1360					NR_002819.2																						ATAAGTTTTTTTCTCTTTGAA	0.428000													25	63					0	0	1	0	0
ASPDH	554235	broad.mit.edu	37	19	51015734	51015734	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:51015734G>C	ENST00000389208.4	-	5	597	c.536C>G	c.(535-537)cCt>cGt	p.P179R	ASPDH_ENST00000376916.3_Missense_Mutation_p.P74R|ASPDH_ENST00000597030.1_5'UTR	NM_001114598.1	NP_001108070.1	A6ND91	ASPD_HUMAN	aspartate dehydrogenase domain containing	179					NAD biosynthetic process|NADP catabolic process		aspartate dehydrogenase activity|NADP binding			endometrium(1)|large_intestine(1)|lung(1)	3						CCCACGGACAGGGCCTTCGTA	0.672000													18	13					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30966288	30966288	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:30966288A>C	ENST00000295055.8	-	13	1582	c.1406T>G	c.(1405-1407)tTc>tGc	p.F469C	CAPN13_ENST00000534090.2_Missense_Mutation_p.F469C	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	469					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TCGGAGCAAGAACTCCGCTGA	0.418000													252	110					0	0	1	0	0
TCL1B	9623	broad.mit.edu	37	14	96152766	96152766	+	Translation_Start_Site	SNP	C	C	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr14:96152766C>A	ENST00000340722.7	+	0	13				RP11-1070N10.6_ENST00000461160.1_RNA	NM_004918.3	NP_004909.1	O95988	TCL1B_HUMAN	T-cell leukemia/lymphoma 1B											cervix(1)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		GAAAGCTACACGTGTGAGCCT	0.697000													24	24					1.48734e-19	1.99955e-19	1	1	0
PCNT	5116	broad.mit.edu	37	21	47805845	47805845	+	Silent	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr21:47805845C>T	ENST00000359568.5	+	17	3518	c.3411C>T	c.(3409-3411)ggC>ggT	p.G1137G	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1137					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					ACCGGGAAGGCGCAAACCTCC	0.607000													51	80					0	0	1	0	0
LRP11	84918	broad.mit.edu	37	6	150157414	150157414	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:150157414C>T	ENST00000239367.2	-	5	1064	c.1059G>A	c.(1057-1059)atG>atA	p.M353I	LRP11_ENST00000546019.1_Missense_Mutation_p.M98I	NM_032832.5	NP_116221.3	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein 11	353						integral to membrane	receptor activity			cervix(1)|kidney(5)|large_intestine(1)|lung(1)	8		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		TGTGGGTTACCATCTTGCGGT	0.507000													16	36					0	0	1	0	0
PDCD7	10081	broad.mit.edu	37	15	65412286	65412286	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr15:65412286C>T	ENST00000204549.4	-	3	1070	c.1016G>A	c.(1015-1017)tGt>tAt	p.C339Y		NM_005707.1	NP_005698.1	Q8N8D1	PDCD7_HUMAN	programmed cell death 7	339					apoptosis|induction of apoptosis|response to glucocorticoid stimulus	U12-type spliceosomal complex				endometrium(4)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	7						GGCTGGAGGACAGACCCCTGG	0.458000													58	163					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2855679	2855679	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:2855679G>C	ENST00000520002.1	-	55	8789	c.8234C>G	c.(8233-8235)cCt>cGt	p.P2745R	CSMD1_ENST00000537824.1_Missense_Mutation_p.P2744R|CSMD1_ENST00000602723.1_Missense_Mutation_p.P2687R|CSMD1_ENST00000400186.3_Missense_Mutation_p.P2687R|CSMD1_ENST00000602557.1_Missense_Mutation_p.P2745R|CSMD1_ENST00000542608.1_Missense_Mutation_p.P2686R			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2745	Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCCGTGGGCAGGGTTTCCAGG	0.478000													46	90					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047689	42047689	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:42047689delG	ENST00000372584.1	-	3	3794	c.2780delC	c.(2779-2781)ctfs	p.P927fs	HIVEP3_ENST00000429157.2_Frame_Shift_Del_p.P927fs|HIVEP3_ENST00000372583.1_Frame_Shift_Del_p.P927fs|HIVEP3_ENST00000247584.5_Frame_Shift_Del_p.P927fs	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	927	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).|Ser-rich.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GCGAGACAGAGGCACAGAGGA	0.607													59	94	---	---	---	---					
VCAM1	7412	broad.mit.edu	37	1	101196842	101196842	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:101196842delC	ENST00000294728.2	+	6	1394	c.1293delC	c.(1291-1293)tafs	p.Y431fs	VCAM1_ENST00000370119.4_Frame_Shift_Del_p.Y369fs|VCAM1_ENST00000370115.1_Intron|VCAM1_ENST00000347652.2_Frame_Shift_Del_p.Y339fs	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	431	Ig-like C2-type 5.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	CTAGCGTGTACCCCCTTGACC	0.463													32	54	---	---	---	---					
AMPD1	270	broad.mit.edu	37	1	115222283	115222283	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:115222283delG	ENST00000369538.3	-	6	948	c.901delC	c.(901-903)agfs	p.Q301fs	AMPD1_ENST00000353928.6_Frame_Shift_Del_p.Q272fs|AMPD1_ENST00000520113.2_Frame_Shift_Del_p.Q305fs	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	272					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TGATGGACCTGGAACTTGGAG	0.413													22	89	---	---	---	---					
PPIAL4G	644591	broad.mit.edu	37	1	143767634	143767634	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:143767634delC	ENST00000419275.1	-	1	247	c.215delG	c.(214-216)gcfs	p.G72fs		NM_001123068.1	NP_001116540.1	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like 4G	72	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(2)|kidney(1)|lung(8)|ovary(1)|skin(1)	14						GTCACCGGTGCCATTAGGGTG	0.473													18	280	---	---	---	---					
CD1E	913	broad.mit.edu	37	1	158324217	158324217	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:158324217delT	ENST00000368160.3	+	2	109	c.109delT	c.(109-111)tcfs	p.F37fs	CD1E_ENST00000368155.3_Frame_Shift_Del_p.F37fs|CD1E_ENST00000368167.3_Frame_Shift_Del_p.F37fs|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000444681.2_Intron|CD1E_ENST00000368161.3_Frame_Shift_Del_p.F37fs|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000368165.3_Frame_Shift_Del_p.F37fs|CD1E_ENST00000434258.1_Frame_Shift_Del_p.F35fs|CD1E_ENST00000464822.1_Intron|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368166.3_Intron|CD1E_ENST00000368156.1_Frame_Shift_Del_p.F37fs|CD1E_ENST00000368163.3_Frame_Shift_Del_p.F37fs|CD1E_ENST00000368154.1_Intron	NM_001042583.2	NP_001036048.1	P15812	CD1E_HUMAN	CD1e molecule	37					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					GCAGCTGTCCTTCCGCATGCT	0.537													30	128	---	---	---	---					
EEF1A1P14	647167	broad.mit.edu	37	1	194158836	194158836	+	RNA	DEL	C	C	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:194158836delC	ENST00000454538.1	+	0	384																											GTGCCTGCCTCCCCAGGATGT	0.507													8	42	---	---	---	---					
URB2	9816	broad.mit.edu	37	1	229770836	229770836	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr1:229770836delG	ENST00000258243.2	+	4	612	c.476delG	c.(475-477)agfs	p.R159fs		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	159						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						TCGGCCTGCAGGCAGCCCGAA	0.592													17	71	---	---	---	---					
ZFP36L2	678	broad.mit.edu	37	2	43452511	43452512	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr2:43452511_43452512insC	ENST00000282388.3	-	2	724_725	c.431_432insG	c.(430-432)gggfs	p.G144fs	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	144	Poly-Gly.				cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				GGGAGCCGCCGCCCCCCTTCTG	0.639													33	15	---	---	---	---					
SCN5A	6331	broad.mit.edu	37	3	38592839	38592839	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:38592839delC	ENST00000413689.1	-	28	5217	c.5024delG	c.(5023-5025)gcfs	p.G1675fs	SCN5A_ENST00000455624.2_Frame_Shift_Del_p.G1642fs|SCN5A_ENST00000451551.2_Frame_Shift_Del_p.G1621fs|SCN5A_ENST00000450102.2_Frame_Shift_Del_p.G1621fs|SCN5A_ENST00000449557.2_Frame_Shift_Del_p.G1621fs|SCN5A_ENST00000443581.1_Frame_Shift_Del_p.G1674fs|SCN5A_ENST00000423572.2_Frame_Shift_Del_p.G1674fs|SCN5A_ENST00000414099.2_Frame_Shift_Del_p.G1657fs|SCN5A_ENST00000333535.4_Frame_Shift_Del_p.G1675fs|SCN5A_ENST00000425664.1_Frame_Shift_Del_p.G1657fs	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1675					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTTGGCCATGCCAAAGATGGA	0.552													93	64	---	---	---	---					
RAD54L2	23132	broad.mit.edu	37	3	51673492	51673493	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:51673492_51673493delGA	ENST00000409535.1	+	12	2043_2044	c.1918_1919delGA	c.(1918-1920)gfs	p.E640fs	RAD54L2_ENST00000296477.3_Frame_Shift_Del_p.E334fs	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	640						nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		CTTGGCCAATGAGCAGGACCTA	0.535													26	27	---	---	---	---					
TNIK	23043	broad.mit.edu	37	3	170846634	170846642	+	In_Frame_Del	DEL	AACTTTGCC	AACTTTGCC	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:170846634_170846642delAACTTTGCC	ENST00000436636.2	-	16	1978_1986	c.1634_1642delGGCAAAGTT	c.(1633-1644)ccc>c	p.RQSS545del	TNIK_ENST00000284483.8_In_Frame_Del_p.RQSS545del|TNIK_ENST00000369326.5_In_Frame_Del_p.RQSS516del|TNIK_ENST00000357327.5_In_Frame_Del_p.RQSS516del|TNIK_ENST00000341852.6_Intron|TNIK_ENST00000460047.1_Intron|TNIK_ENST00000470834.1_In_Frame_Del_p.RQSS516del|TNIK_ENST00000538048.1_Intron|TNIK_ENST00000488470.1_Intron|TNIK_ENST00000475336.1_Intron	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	545	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			ATGGCAGGGGAACTTTGCCGGTTGAGCCT	0.469													6	8	---	---	---	---					
SLC51A	200931	broad.mit.edu	37	3	195955100	195955102	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr3:195955100_195955102delCTG	ENST00000296327.5	+	5	686_688	c.477_479delCTG	c.(475-480)ccc>cc	p.PC159del		NM_152672.5	NP_689885.4			solute carrier family 51, alpha subunit																		ACACAGGCCCctgctgctgctgc	0.665													10	248	---	---	---	---					
EBF1	1879	broad.mit.edu	37	5	158158152	158158152	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr5:158158152delG	ENST00000313708.6	-	11	1332	c.1050delC	c.(1048-1050)ccfs	p.P350fs	EBF1_ENST00000380654.4_Frame_Shift_Del_p.P319fs|EBF1_ENST00000518836.1_5'UTR|EBF1_ENST00000517373.1_Frame_Shift_Del_p.P342fs	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	350					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AATCGATGGTGGGTTCGTTGA	0.438			T	HMGA2	lipoma								26	21	---	---	---	---					
RRP36	88745	broad.mit.edu	37	6	42989414	42989419	+	In_Frame_Del	DEL	GCCGGG	GCCGGG	-	rs60664426		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:42989414_42989419delGCCGGG	ENST00000244496.5	+	1	32_37	c.22_27delGCCGGG	c.(22-27)del	p.AG14del		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	14					ribosomal small subunit biogenesis|rRNA processing	nucleolus		p.A8_G9delAG(2)		NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						TAACTAccgcgccggggccggggccg	0.777													6	11	---	---	---	---					
SLC35F1	222553	broad.mit.edu	37	6	118606439	118606440	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr6:118606439_118606440insA	ENST00000360388.4	+	7	1141_1142	c.940_941insA	c.(940-942)ctcfs	p.L314fs		NM_001029858.3	NP_001025029.2	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	314					transport	integral to membrane				breast(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(226;0.217)		TTCAGTCAACCTCTCCTTGCTC	0.465											OREG0017635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	129	261	---	---	---	---					
TMEM184A	202915	broad.mit.edu	37	7	1586653	1586654	+	In_Frame_Ins	INS	-	-	GCC	rs112463195	by1000genomes	TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:1586653_1586654insGCC	ENST00000297477.5	-	9	1492_1493	c.1176_1177insGGC	c.(1174-1179)ggccgg>ggGGCccgg	p.392_393GR>GAR		NM_001097620.1	NP_001091089.1	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	392						integral to membrane				endometrium(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		CTCCCGCCGGAGCCGCCGCTGG	0.708													21	24	---	---	---	---					
ABCB1	5243	broad.mit.edu	37	7	87133630	87133634	+	Frame_Shift_Del	DEL	GATGC	GATGC	-	rs149482536	byFrequency	TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:87133630_87133634delGATGC	ENST00000265724.3	-	29	4185_4189	c.3768_3772delGCATC	c.(3766-3774)acagfs	p.THQ1256fs	ABCB1_ENST00000488737.2_5'UTR|ABCB1_ENST00000543898.1_Frame_Shift_Del_p.THQ1192fs	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	1256	ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AGCAGCTGCTGATGCGTGCCATGCT	0.488													13	96	---	---	---	---					
NYAP1	222950	broad.mit.edu	37	7	100084787	100084787	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:100084787delC	ENST00000423930.1	+	3	571	c.412delC	c.(412-414)ccfs	p.P139fs	NYAP1_ENST00000300179.2_Frame_Shift_Del_p.P139fs|NYAP1_ENST00000454988.1_Frame_Shift_Del_p.P82fs			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	139																	GGCAGAGACGCCCCCCAGCAA	0.667													17	20	---	---	---	---					
ADCK2	90956	broad.mit.edu	37	7	140373568	140373588	+	In_Frame_Del	DEL	CAAACTGGGCCAGTGGGCCAG	CAAACTGGGCCAGTGGGCCAG	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:140373568_140373588delCAAACTGGGCCAGTGGGCCAG	ENST00000072869.4	+	1	616_636	c.438_458delCAAACTGGGCCAGTGGGCCAG	c.(436-459)atc>at	p.IKLGQWAS146del	ADCK2_ENST00000476491.1_In_Frame_Del_p.IKLGQWAS146del	NM_052853.3	NP_443085.2	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	146						integral to membrane	ATP binding|protein serine/threonine kinase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|skin(4)	15	Melanoma(164;0.00956)					CAACCTACATCAAACTGGGCCAGTGGGCCAGCACCCGGCGC	0.606													24	115	---	---	---	---					
OR9A4	130075	broad.mit.edu	37	7	141619579	141619579	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr7:141619579delC	ENST00000548136.1	+	1	963	c.904delC	c.(904-906)ggfs	p.R302fs	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					AGAGGCCCTTCGGGATGGGGT	0.423													39	55	---	---	---	---					
LOC101929066	101929066	broad.mit.edu	37	8	17947397	17947398	+	RNA	INS	-	-	T	rs148283356		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:17947397_17947398insT	ENST00000499554.2	+	0	483				CTD-2547L16.1_ENST00000521775.1_RNA																							TAATGCTAttcttttttttttt	0.376													2	4	---	---	---	---					
UNC5D	137970	broad.mit.edu	37	8	35631840	35631841	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:35631840_35631841insT	ENST00000287272.2	+	15	2315_2316	c.2295_2296insT	c.(2293-2298)tttcgcfs	p.R766fs	UNC5D_ENST00000416672.1_Frame_Shift_Ins_p.R840fs|UNC5D_ENST00000449677.1_Frame_Shift_Ins_p.R411fs|UNC5D_ENST00000453357.2_Frame_Shift_Ins_p.R830fs|UNC5D_ENST00000420357.1_Frame_Shift_Ins_p.R768fs|UNC5D_ENST00000404895.2_Frame_Shift_Ins_p.R835fs			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	835					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CCATCACTTTCTTCGCACAAGA	0.426													16	89	---	---	---	---					
TG	7038	broad.mit.edu	37	8	133899343	133899343	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr8:133899343delG	ENST00000220616.4	+	9	1766	c.1726delG	c.(1726-1728)aafs	p.E576fs	TG_ENST00000377869.1_Frame_Shift_Del_p.E576fs	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	576					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGAGCTTCCAGAATTCCTTCT	0.448													20	104	---	---	---	---					
WNK2	65268	broad.mit.edu	37	9	96055090	96055090	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr9:96055090delC	ENST00000297954.4	+	23	5454	c.5454delC	c.(5452-5454)agfs	p.S1818fs	WNK2_ENST00000395477.2_Frame_Shift_Del_p.S1781fs|WNK2_ENST00000427277.2_Frame_Shift_Del_p.S1393fs|WNK2_ENST00000356055.3_Frame_Shift_Del_p.S145fs|WNK2_ENST00000349097.3_Frame_Shift_Del_p.S1430fs|WNK2_ENST00000395475.2_3'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1818					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CCCCCTCCAGCCCCGACGTGA	0.706													2	4	---	---	---	---					
CACNB2	783	broad.mit.edu	37	10	18690967	18690967	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:18690967delG	ENST00000396576.2	+	2	664	c.163delG	c.(163-165)cafs	p.A55fs	CACNB2_ENST00000377319.3_Frame_Shift_Del_p.A55fs|CACNB2_ENST00000377328.1_Frame_Shift_Del_p.A110fs|CACNB2_ENST00000377329.4_Frame_Shift_Del_p.A56fs|CACNB2_ENST00000377331.2_Frame_Shift_Del_p.A82fs|CACNB2_ENST00000324631.7_Frame_Shift_Del_p.A110fs|CACNB2_ENST00000352115.6_Frame_Shift_Del_p.A110fs|CACNB2_ENST00000282343.8_Frame_Shift_Del_p.A82fs|CACNB2_ENST00000377315.4_Frame_Shift_Del_p.A62fs	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	110					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GTTGGAAAAAGCAAAGGTAAA	0.537													16	63	---	---	---	---					
AGAP11	119385	broad.mit.edu	37	10	88761384	88761384	+	RNA	DEL	C	C	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr10:88761384delC	ENST00000444431.1	+	0	2514				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										CACTTCCCTTCCCCTTCAGGT	0.388													42	39	---	---	---	---					
DCHS1	8642	broad.mit.edu	37	11	6662745	6662746	+	In_Frame_Ins	INS	-	-	CAG	rs56194704		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:6662745_6662746insCAG	ENST00000299441.3	-	2	510_511	c.99_100insCTG	c.(97-102)ctgggc>ctCTGgggc	p.33_34LG>LWG		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	33					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.L33_G34insL(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCCCAGCCCCcagcagcagca	0.639													3	4	---	---	---	---					
NLRP10	338322	broad.mit.edu	37	11	7981203	7981204	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:7981203_7981204insT	ENST00000328600.2	-	2	2116_2117	c.1955_1956insA	c.(1954-1956)aacfs	p.N652fs		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	652							ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		atatgtaagtatttTTTGGTGT	0.376													19	25	---	---	---	---					
AHNAK	79026	broad.mit.edu	37	11	62292621	62292622	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr11:62292621_62292622insG	ENST00000378024.4	-	5	9541_9542	c.9267_9268insC	c.(9265-9270)ccagatfs	p.D3090fs	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3090					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				ATGGAGATCTTGGGGGCTTTGA	0.460													157	324	---	---	---	---					
HS3ST4	9951	broad.mit.edu	37	16	26147463	26147464	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr16:26147463_26147464insA	ENST00000331351.5	+	2	1657_1658	c.1265_1266insA	c.(1264-1266)cgafs	p.R422fs	HS3ST4_ENST00000475436.1_3'UTR	NM_006040.2	NP_006031.2	Q9Y661	HS3S4_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 4	422					heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(2)|endometrium(3)|large_intestine(1)|lung(9)	15				GBM - Glioblastoma multiforme(48;0.0988)		CGCATTGACCCAGATGTCATCC	0.475													14	21	---	---	---	---					
EEF2	1938	broad.mit.edu	37	19	3981953	3981954	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:3981953_3981954insG	ENST00000309311.6	-	6	976_977	c.888_889insC	c.(886-891)cctcttfs	p.L297fs		NM_001961.3	NP_001952.1	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	297						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTTGAAGATGGGGTCCAGGA	0.653													58	165	---	---	---	---					
MCOLN1	57192	broad.mit.edu	37	19	7589876	7589876	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:7589876delG	ENST00000264079.6	+	2	186	c.61delG	c.(61-63)ggfs	p.G21fs		NM_020533.2	NP_065394.1	Q9GZU1	MCLN1_HUMAN	mucolipin 1	21					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CCCCAACCCCGGGTATGGGAC	0.617													19	48	---	---	---	---					
ADCK4	79934	broad.mit.edu	37	19	41220505	41220505	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr19:41220505delC	ENST00000324464.3	-	2	334	c.33delG	c.(31-33)ggfs	p.G11fs	ADCK4_ENST00000243583.6_Frame_Shift_Del_p.G11fs|ADCK4_ENST00000450541.1_Frame_Shift_Del_p.G11fs	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	11						integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			GTCCACCGGTCCCCCGAAGTA	0.657													49	61	---	---	---	---					
TOP3B	8940	broad.mit.edu	37	22	22317262	22317262	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chr22:22317262delC	ENST00000398793.2	-	12	1642	c.1208delG	c.(1207-1209)gtfs	p.G403fs	TOP3B_ENST00000413067.2_Frame_Shift_Del_p.G132fs|TOP3B_ENST00000357179.5_Frame_Shift_Del_p.G403fs	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	403					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		CCACGCGTCACCCCCTGCAAC	0.607													17	34	---	---	---	---					
SHROOM4	57477	broad.mit.edu	37	X	50350814	50350814	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:50350814delC	ENST00000376020.2	-	6	3353	c.3328delG	c.(3328-3330)agfs	p.E1110fs	SHROOM4_ENST00000289292.7_Frame_Shift_Del_p.E1110fs|SHROOM4_ENST00000460112.3_Frame_Shift_Del_p.E994fs	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1110					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					CTGTACTTCTCCCAGTTGGGA	0.562													26	10	---	---	---	---					
NUDT11	55190	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			10	10	---	---	---	---					
HEPH	9843	broad.mit.edu	37	X	65486287	65486287	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:65486287delC	ENST00000519389.1	+	21	3591	c.3412delC	c.(3412-3414)ccfs	p.P1139fs	HEPH_ENST00000441993.2_Frame_Shift_Del_p.P1087fs|HEPH_ENST00000343002.2_Frame_Shift_Del_p.P1085fs|HEPH_ENST00000336279.5_Frame_Shift_Del_p.P818fs|HEPH_ENST00000419594.1_Frame_Shift_Del_p.P896fs|HEPH_ENST00000374727.3_Frame_Shift_Del_p.P1088fs			Q9BQS7	HEPH_HUMAN	hephaestin	1085					cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						TTCAGCAGTGCCCCCCAGAGA	0.438													25	10	---	---	---	---					
MAP2K4P1	139201	broad.mit.edu	37	X	72744763	72744763	+	RNA	DEL	T	T	-			TCGA-CN-A63U-01A-11D-A30E-08	TCGA-CN-A63U-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06f0ce6c-d91c-40ef-afc5-43a86e4a39d8	7cbcd18d-f2f6-4114-a1f7-5c70911a3c8e	g.chrX:72744763delT	ENST00000602584.1	-	0	1886					NR_029423.1																						CTCTCAGCCCTTTTTTTTAGT	0.413													4	9	---	---	---	---					
