Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AC226119.5	0	broad.mit.edu	37	4	3954855	3954855	+	RNA	SNP	G	G	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr4:3954855G>T	ENST00000281228.8	-	0	143				FAM86EP_ENST00000313946.8_RNA																							AAAATATCCCGCCGCAGCTCA	0.493000													4	125					1.23904e-05	1.33896e-05	1	1	0
GOLGA8EP	390535	broad.mit.edu	37	15	23445474	23445474	+	RNA	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr15:23445474G>A	ENST00000526079.1	+	0	2294					NR_027407.1|NR_033350.1																						CATGACCATCGTCAAAGACCT	0.433000													4	132					0	0	1	0	0
C14orf182	283551	broad.mit.edu	37	14	50472372	50472372	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr14:50472372C>T	ENST00000399206.1	-	1	1866	c.146G>A	c.(145-147)cGa>cAa	p.R49Q	C14orf182_ENST00000529902.1_5'UTR	NM_001012706.1	NP_001012724.1	A1A4T8	CN182_HUMAN	chromosome 14 open reading frame 182	49										large_intestine(2)|urinary_tract(1)	3						ATGTCTGTGTCGTAGAACTGT	0.527000													81	104					0	0	1	0	0
TRIM60	166655	broad.mit.edu	37	4	165961778	165961778	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr4:165961778C>T	ENST00000512596.1	+	3	770	c.554C>T	c.(553-555)tCt>tTt	p.S185F	TRIM60_ENST00000341062.5_Missense_Mutation_p.S185F|TRIM60_ENST00000508504.1_Missense_Mutation_p.S185F	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	185						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		GAAATAAATTCTGAGTTTGAG	0.318000													28	39					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67682147	67682147	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr16:67682147G>A	ENST00000334583.6	+	14	1592	c.1264G>A	c.(1264-1266)Gca>Aca	p.A422T	RLTPR_ENST00000545661.1_Missense_Mutation_p.A386T	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	422										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GCAGCTCTTCGCAGCGGTATC	0.716000													9	0					0	0	1	0	0
GPR84	53831	broad.mit.edu	37	12	54756501	54756501	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr12:54756501G>A	ENST00000551809.1	-	1	1770	c.1135C>T	c.(1135-1137)Caa>Taa	p.Q379*	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA|GPR84_ENST00000267015.3_Nonsense_Mutation_p.Q379*			Q9NQS5	GPR84_HUMAN	G protein-coupled receptor 84	379						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|kidney(2)|large_intestine(6)|lung(5)|skin(1)|urinary_tract(1)	18						CCATATGCTTGGCGGAATTGG	0.547000													7	341					0	0	1	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291581	141291581	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chrX:141291581C>A	ENST00000247452.3	-	3	540	c.193G>T	c.(193-195)Ggt>Tgt	p.G65C		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	65						cytoplasm|nucleus		p.G65R(1)		NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGGACCACCAAGAATC	0.532000										HNSCC(46;0.14)			41	19					5.43694e-19	6.17415e-19	1	1	0
GRIK2	2898	broad.mit.edu	37	6	102134192	102134192	+	Silent	SNP	G	G	A	rs145542805	by1000genomes	TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr6:102134192G>A	ENST00000369138.1	+	6	1405	c.915G>A	c.(913-915)ccG>ccA	p.P305P	GRIK2_ENST00000369134.4_Silent_p.P256P|GRIK2_ENST00000358361.3_Silent_p.P305P|GRIK2_ENST00000318991.6_Silent_p.P305P|GRIK2_ENST00000413795.1_Silent_p.P305P|GRIK2_ENST00000421544.1_Silent_p.P305P|GRIK2_ENST00000369137.3_Silent_p.P305P	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	305					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	AGGCACCTCCGAAACCCGATT	0.393000													25	73					0	0	1	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58850179	58850179	+	Silent	SNP	G	G	A	rs139283341	byFrequency	TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr19:58850179G>A	ENST00000329665.4	+	3	1110	c.963G>A	c.(961-963)gcG>gcA	p.A321A		NM_181846.2	NP_862829.1	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	321					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A321A(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|pancreas(1)|prostate(2)	16		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		ACACAGGGGCGAAGCCCCATG	0.567000													79	149					0	0	1	0	0
ZBTB22	9278	broad.mit.edu	37	6	33284458	33284458	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr6:33284458G>A	ENST00000431845.2	-	2	387	c.236C>T	c.(235-237)tCc>tTc	p.S79F	ZBTB22_ENST00000418724.1_Missense_Mutation_p.S79F	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	79	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						GAAGTAAGGGGAGGAGGCAGC	0.602000													46	81					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38505847	38505847	+	Splice_Site	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr7:38505847G>A	ENST00000356264.2	-	8	807	c.590_splice	c.e8-1	p.R198_splice	AMPH_ENST00000325590.5_Splice_Site_p.R198_splice|AMPH_ENST00000428293.2_Splice_Site_p.R198_splice	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	198	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						AATCCAACTCGTCTGCCATGT	0.368000													17	30					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76262786	76262786	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr1:76262786C>T	ENST00000263187.3	+	1	220	c.116C>T	c.(115-117)cCa>cTa	p.P39L		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	39					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						CAGGAGACTCCACAGAGCCGC	0.652000								Mismatch excision repair (MMR)					18	26					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195511822	195511822	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr3:195511822G>T	ENST00000463781.3	-	2	7088	c.6629C>A	c.(6628-6630)cCt>cAt	p.P2210H	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.P2210H	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	999					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.P2210H(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GCTGGTGACAGGAAGAGGGGT	0.597000													3	12					0.115264	0.120667	1	1	0
ENPP6	133121	broad.mit.edu	37	4	185012391	185012391	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr4:185012391G>A	ENST00000296741.2	-	8	1403	c.1262C>T	c.(1261-1263)gCc>gTc	p.A421V		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	421					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		GACAGGCGGGGCAGTGCTGGC	0.557000													23	66					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115891640	115891640	+	Silent	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr4:115891640G>A	ENST00000264363.2	-	4	1845	c.1167C>T	c.(1165-1167)ttC>ttT	p.F389F		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	389	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ACTCGTTGTGGAAGAGGTGGG	0.443000													30	45					0	0	1	0	0
COBLL1	22837	broad.mit.edu	37	2	165551421	165551421	+	Silent	SNP	G	G	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr2:165551421G>T	ENST00000375458.2	-	11	2702	c.2481C>A	c.(2479-2481)ccC>ccA	p.P827P	COBLL1_ENST00000409184.3_Silent_p.P865P|COBLL1_ENST00000392717.2_Silent_p.P903P|COBLL1_ENST00000342193.4_Silent_p.P865P|COBLL1_ENST00000194871.6_Silent_p.P932P	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	903										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						TTGTCATTTTGGGAGCAGGTT	0.433000													53	71					4.17463e-26	4.82242e-26	1	1	0
AC226119.5	0	broad.mit.edu	37	4	3954857	3954857	+	RNA	SNP	C	C	A	rs17410899		TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr4:3954857C>A	ENST00000281228.8	-	0	141				FAM86EP_ENST00000313946.8_RNA																							AATATCCCGCCGCAGCTCAGA	0.488000													4	131					0.184627	0.184627	1	1	0
NIN	51199	broad.mit.edu	37	14	51239789	51239789	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr14:51239789G>C	ENST00000245441.5	-	8	881	c.691C>G	c.(691-693)Ctt>Gtt	p.L231V	NIN_ENST00000389868.3_Missense_Mutation_p.L231V|NIN_ENST00000530997.2_Missense_Mutation_p.L231V|NIN_ENST00000453196.1_Missense_Mutation_p.L231V|NIN_ENST00000382041.3_Missense_Mutation_p.L231V|NIN_ENST00000382043.4_Missense_Mutation_p.L231V|NIN_ENST00000324330.9_Missense_Mutation_p.L231V	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	231	EF-hand 4.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					TCAGGATCAAGATTATGGAAT	0.358000			T	PDGFRB	MPD								42	49					0	0	1	0	0
TAOK3	51347	broad.mit.edu	37	12	118636903	118636903	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr12:118636903C>T	ENST00000392533.3	-	13	1637	c.1147G>A	c.(1147-1149)Gat>Aat	p.D383N	TAOK3_ENST00000419821.2_Missense_Mutation_p.D383N	NM_016281.3	NP_057365.3	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	383	Ser-rich.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)|skin(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTTTCGTCATCGTGCATCATG	0.502000													79	97					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936212	4936212	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr11:4936212G>A	ENST00000322013.3	-	1	710	c.682C>T	c.(682-684)Cgc>Tgc	p.R228C	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCACGGTGCGCAGGATCAGA	0.522000													26	29					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24537631	24537631	+	Silent	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr5:24537631G>A	ENST00000264463.4	-	3	891	c.384C>T	c.(382-384)cgC>cgT	p.R128R		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	128	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R128R(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TAGCTTGTGCGCGTAGAGTAT	0.413000										HNSCC(23;0.051)			125	77					0	0	1	0	0
FER	2241	broad.mit.edu	37	5	108290547	108290547	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr5:108290547C>G	ENST00000281092.4	+	12	1831	c.1447C>G	c.(1447-1449)Cga>Gga	p.R483G	FER_ENST00000438717.2_Missense_Mutation_p.R308G|FER_ENST00000536402.1_3'UTR	NM_005246.2	NP_005237.2	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	483	SH2.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			NS(2)|biliary_tract(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	32		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		CTTTTTGGTGCGAGAGAGTCA	0.408000													43	123					0	0	1	0	0
SIKE1	80143	broad.mit.edu	37	1	115323142	115323142	+	Silent	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr1:115323142C>T	ENST00000369528.5	-	1	164	c.87G>A	c.(85-87)ctG>ctA	p.L29L	SIKE1_ENST00000060969.5_Silent_p.L29L|SIKE1_ENST00000506320.1_5'UTR	NM_001102396.1|NM_025073.2	NP_001095866.1|NP_079349.2	Q9BRV8	SIKE1_HUMAN	suppressor of IKBKE 1	29						cytosol	protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(2)	6						ACTGATCCACCAGCGACTCGG	0.662000													31	23					0	0	1	0	0
CNKSR3	154043	broad.mit.edu	37	6	154763341	154763341	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr6:154763341A>T	ENST00000607772.1	-	3	844	c.300T>A	c.(298-300)agT>agA	p.S100R	CNKSR3_ENST00000479339.1_Missense_Mutation_p.S20R	NM_173515.2	NP_775786.2	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	100	CRIC.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	15		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		TCCGTCGGCTACTTATGTAAT	0.498000													63	108					0	0	1	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149213163	149213163	+	Silent	SNP	G	G	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr5:149213163G>T	ENST00000309241.5	+	5	1559	c.1527G>T	c.(1525-1527)ctG>ctT	p.L509L	PPARGC1B_ENST00000360453.4_Silent_p.L470L|PPARGC1B_ENST00000394320.3_Silent_p.L509L|PPARGC1B_ENST00000403750.1_Silent_p.L445L	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	509					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TGCCCTCACTGTGCCTGGCTC	0.667000													5	14					0.184627	0.184627	1	1	0
DNTT	1791	broad.mit.edu	37	10	98092349	98092349	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr10:98092349C>T	ENST00000419175.1	+	9	1525	c.1355C>T	c.(1354-1356)tCc>tTc	p.S452F	DNTT_ENST00000371174.2_Missense_Mutation_p.S452F	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	452	Mediates interaction with DNTTIP2.			S -> SP (in Ref. 2; AAA53100).	DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		TGGACTGGCTCCCGGGTAAGT	0.582000													89	135					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69349299	69349299	+	Silent	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr6:69349299G>A	ENST00000370598.1	+	3	1553	c.732G>A	c.(730-732)agG>agA	p.R244R		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	244					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				ATCTTACCAGGGAGGCCAAGC	0.527000													10	30					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18039775	18039775	+	Silent	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr17:18039775C>T	ENST00000205890.5	+	14	4979	c.4641C>T	c.(4639-4641)agC>agT	p.S1547S		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	1547	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CTGTGGAGAGCGCTGTGGATG	0.642000													37	48					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121435642	121435642	+	Silent	SNP	A	A	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr3:121435642A>T	ENST00000393667.3	-	9	1340	c.1230T>A	c.(1228-1230)ctT>ctA	p.L410L	GOLGB1_ENST00000340645.5_Silent_p.L405L	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	405					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TATCTTGGAGAAGCTTTGAAT	0.433000													65	106					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63554045	63554045	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr17:63554045C>G	ENST00000307078.5	-	2	1007	c.694G>C	c.(694-696)Gag>Cag	p.E232Q	AXIN2_ENST00000375702.5_Missense_Mutation_p.E232Q|CTD-2535L24.2_ENST00000577662.1_3'UTR	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	232					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						GTCCACTCCTCTTCTTCATTC	0.537000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				44	73					0	0	1	0	0
FUT7	2529	broad.mit.edu	37	9	139925703	139925703	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr9:139925703G>A	ENST00000314412.6	-	2	1506	c.488C>T	c.(487-489)tCg>tTg	p.S163L	C9orf139_ENST00000314330.2_Intron	NM_004479.3	NP_004470.1	Q11130	FUT7_HUMAN	fucosyltransferase 7 (alpha (1,3) fucosyltransferase)	163					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|lung(4)|ovary(1)|skin(1)	8	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		CAGCGGTGGCGAGGGCCCCCA	0.682000													16	17					0	0	1	0	0
ABHD1	84696	broad.mit.edu	37	2	27352652	27352652	+	Silent	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr2:27352652C>T	ENST00000316470.4	+	6	762	c.648C>T	c.(646-648)gcC>gcT	p.A216A		NM_032604.3	NP_115993.3	Q96SE0	ABHD1_HUMAN	abhydrolase domain containing 1	216						integral to membrane	carboxylesterase activity			endometrium(1)|kidney(1)|lung(3)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGCACAGGCCAGGCAGGCTG	0.557000													29	45					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5265138	5265138	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr19:5265138C>T	ENST00000372412.4	-	5	682	c.449G>A	c.(448-450)cGg>cAg	p.R150Q	PTPRS_ENST00000587303.1_Missense_Mutation_p.R150Q|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000588012.1_Missense_Mutation_p.R150Q|PTPRS_ENST00000592099.1_Missense_Mutation_p.R150Q|PTPRS_ENST00000262963.6_Missense_Mutation_p.R150Q|PTPRS_ENST00000348075.2_Missense_Mutation_p.R150Q|PTPRS_ENST00000357368.4_Missense_Mutation_p.R150Q|PTPRS_ENST00000353284.2_Missense_Mutation_p.R150Q			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	150	Ig-like C2-type 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGTGGCTGTCCGTGTCCGCTC	0.602000													28	37					0	0	1	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587657	43587657	+	RNA	SNP	C	C	T	rs148404065	by1000genomes	TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr17:43587657C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GGTGACAACACATCTGTTTTA	0.323000													4	55					0	0	1	0	0
PRAMEF7	441871	broad.mit.edu	37	1	12979758	12979758	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr1:12979758G>A	ENST00000361079.2	+	4	1033	c.950G>A	c.(949-951)aGc>aAc	p.S317N						PRAME family member 7											endometrium(2)|kidney(5)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	18	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTGCCCGAGCATCCGTCAA	0.577000													35	227					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179432589	179432589	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr2:179432589G>C	ENST00000589042.1	-	326	78494	c.78270C>G	c.(78268-78270)gaC>gaG	p.D26090E	TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D17150E|TTN_ENST00000342175.6_Missense_Mutation_p.D17217E|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D23522E|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D24449E|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D17025E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24449	Ig-like 126.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCTGGTGGGTCACAGGGAT	0.403000													128	170					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112989706	112989706	+	Missense_Mutation	SNP	C	C	G	rs140032333		TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr3:112989706C>G	ENST00000495514.1	+	6	1286	c.582C>G	c.(580-582)gaC>gaG	p.D194E	BOC_ENST00000273395.4_Missense_Mutation_p.D194E|BOC_ENST00000355385.3_Missense_Mutation_p.D194E			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	194	Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			GCCAGGAGGACGAGGGCATGT	0.607000													51	79					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637363	248637363	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr1:248637363G>A	ENST00000359594.2	+	1	737	c.712G>A	c.(712-714)Ggc>Agc	p.G238S		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	238					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTCTGCCGCCGGCCACAGGAA	0.562000													93	135					0	0	1	0	0
ACTG2	72	broad.mit.edu	37	2	74128448	74128448	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr2:74128448G>A	ENST00000409624.1	+	3	653	c.10G>A	c.(10-12)Gag>Aag	p.E4K	ACTG2_ENST00000409918.1_Missense_Mutation_p.E4K|ACTG2_ENST00000409731.3_Missense_Mutation_p.E4K|ACTG2_ENST00000345517.3_Missense_Mutation_p.E4K			P63267	ACTH_HUMAN	actin, gamma 2, smooth muscle, enteric	4					muscle contraction	cytoskeleton|cytosol	ATP binding			large_intestine(3)|lung(14)|skin(1)	18						CATGTGTGAAGAGGAGACCAC	0.582000													17	38					0	0	1	0	0
TM6SF1	53346	broad.mit.edu	37	15	83793513	83793513	+	Silent	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr15:83793513C>T	ENST00000322019.9	+	7	967	c.693C>T	c.(691-693)tgC>tgT	p.C231C	TM6SF1_ENST00000379386.4_Silent_p.C234C|TM6SF1_ENST00000379390.6_Intron|TM6SF1_ENST00000565774.1_Silent_p.C231C			Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1	231						integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						CTGGATTTTGCCTGTTCAGAG	0.363000													4	94					0	0	1	0	0
ZNF728	388523	broad.mit.edu	37	19	23159455	23159455	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr19:23159455G>C	ENST00000594710.1	-	4	829	c.684C>G	c.(682-684)tgC>tgG	p.C228W		NM_001267716.1	NP_001254645.1			zinc finger protein 728																		CTTCACATTTGCAGGGTTTCT	0.373000													27	59					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49167739	49167739	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr3:49167739G>A	ENST00000418109.1	-	10	1314	c.1150C>T	c.(1150-1152)Cgc>Tgc	p.R384C	LAMB2_ENST00000305544.4_Missense_Mutation_p.R384C	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	384	Laminin EGF-like 2.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCACAGTGGCGCCCAGCTGTG	0.607000													25	12					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105456579	105456579	+	Silent	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr8:105456579C>T	ENST00000351513.2	-	4	822	c.690G>A	c.(688-690)acG>acA	p.T230T		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	230					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGGCTCTCAGCGTGGCCTCTG	0.562000													44	66					0	0	1	0	0
KCNV2	169522	broad.mit.edu	37	9	2718573	2718573	+	Silent	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr9:2718573G>A	ENST00000382082.3	+	1	1072	c.834G>A	c.(832-834)gcG>gcA	p.A278A		NM_133497.3	NP_598004.1	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	278						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	35				GBM - Glioblastoma multiforme(50;0.0257)		TGGCGCTGGCGCTCAACACCG	0.677000													24	15					0	0	1	0	0
PTGER3	5733	broad.mit.edu	37	1	71478083	71478083	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr1:71478083A>T	ENST00000370924.4	-	2	1212	c.982T>A	c.(982-984)Ttc>Atc	p.F328I	PTGER3_ENST00000356595.4_Missense_Mutation_p.F328I|PTGER3_ENST00000351052.5_Missense_Mutation_p.F328I|PTGER3_ENST00000354608.5_Missense_Mutation_p.F328I|PTGER3_ENST00000306666.5_Missense_Mutation_p.F328I|PTGER3_ENST00000414819.1_Missense_Mutation_p.F328I|PTGER3_ENST00000370932.2_Missense_Mutation_p.F328I|PTGER3_ENST00000460330.1_Missense_Mutation_p.F328I|PTGER3_ENST00000370931.3_Missense_Mutation_p.F328I	NM_198715.2	NP_942008.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	328					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	GCTATTAAGAAGAAGTTGCAT	0.423000													33	43					0	0	1	0	0
STAT3	6774	broad.mit.edu	37	17	40481604	40481604	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr17:40481604T>C	ENST00000264657.5	-	13	1513	c.1201A>G	c.(1201-1203)Aac>Gac	p.N401D	STAT3_ENST00000389272.3_Missense_Mutation_p.N303D|STAT3_ENST00000588969.1_Missense_Mutation_p.N401D|STAT3_ENST00000404395.3_Missense_Mutation_p.N401D|STAT3_ENST00000585517.1_Missense_Mutation_p.N401D	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)	401					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		AGGCTGCCGTTGTTGGATTCT	0.498000									Hyperimmunoglobulin E Recurrent Infection Syndrome				95	98					0	0	1	0	0
SPATA21	374955	broad.mit.edu	37	1	16725272	16725272	+	Silent	SNP	A	A	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr1:16725272A>T	ENST00000335496.1	-	13	1880	c.1398T>A	c.(1396-1398)gcT>gcA	p.A466A	SPATA21_ENST00000466212.1_Intron|SPATA21_ENST00000540400.1_Silent_p.A443A	NM_198546.1	NP_940948.1	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	466							calcium ion binding			breast(1)|endometrium(2)|lung(8)|ovary(2)|pancreas(3)|stomach(1)|urinary_tract(2)	19		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		AGTGGGTTCGAGCTGGCACAG	0.587000													22	39					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128452143	128452143	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr7:128452143A>G	ENST00000297788.4	+	13	2685	c.2318A>G	c.(2317-2319)tAc>tGc	p.Y773C	CCDC136_ENST00000378685.4_Intron|CCDC136_ENST00000487361.1_Intron|CCDC136_ENST00000464832.1_Intron	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	773	Ser-rich.					integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						GAGAGCTATTACAAGAGTTAC	0.502000													28	48					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121929549	121929549	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr9:121929549C>T	ENST00000265922.3	-	8	2560	c.2099G>A	c.(2098-2100)cGg>cAg	p.R700Q	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		700					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						AATTCGGTCCCGAATATCCAA	0.572000													9	130					0	0	1	0	0
CPXCR1	53336	broad.mit.edu	37	X	88008757	88008757	+	Silent	SNP	A	A	C			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chrX:88008757A>C	ENST00000276127.4	+	3	601	c.342A>C	c.(340-342)tcA>tcC	p.S114S	CPXCR1_ENST00000373111.1_Silent_p.S114S	NM_033048.5	NP_149037.4	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	114						intracellular	zinc ion binding			NS(1)|cervix(1)|kidney(1)|large_intestine(11)|liver(1)|lung(20)|ovary(3)|upper_aerodigestive_tract(2)	40						GATCCCACTCAGGGAAAGTTG	0.393000													31	4					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77797326	77797326	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr7:77797326C>T	ENST00000354212.4	-	15	2756	c.2503G>A	c.(2503-2505)Ggc>Agc	p.G835S	MAGI2_ENST00000419488.1_Missense_Mutation_p.G821S|MAGI2_ENST00000522391.1_Missense_Mutation_p.G835S	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	835	PDZ 4.					cell junction|synapse|synaptosome	phosphatase binding	p.G835S(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGGGTTTTGCCGGCTACTGGA	0.537000													4	184					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73326535	73326535	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr10:73326535G>A	ENST00000224721.6	+	6	486	c.481G>A	c.(481-483)Gcc>Acc	p.A161T	CDH23_ENST00000398842.3_Missense_Mutation_p.A156T|CDH23_ENST00000461841.3_Missense_Mutation_p.A201T|CDH23_ENST00000398809.4_Missense_Mutation_p.A156T|CDH23_ENST00000299366.7_Missense_Mutation_p.A201T	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	156	Cadherin 2.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CATCGTGAATGCCACAGACCC	0.612000													20	18					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235945231	235945231	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr1:235945231G>T	ENST00000389794.3	-	15	5193	c.5019C>A	c.(5017-5019)ttC>ttA	p.F1673L	LYST_ENST00000389793.2_Missense_Mutation_p.F1673L|LYST_ENST00000536965.1_3'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1673					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			actcaccgttgaaGAGAAGCA	0.403000													36	42					6.04917e-29	7.11043e-29	1	1	0
SLC32A1	140679	broad.mit.edu	37	20	37357219	37357219	+	Silent	SNP	G	G	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr20:37357219G>A	ENST00000217420.1	+	2	1778	c.1515G>A	c.(1513-1515)gtG>gtA	p.V505V		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	505					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TCTGCAGCGTGTCCGGCTTCG	0.657000													4	43					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21605732	21605732	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr1:21605732C>A	ENST00000415912.2	-	3	309	c.184G>T	c.(184-186)Gca>Tca	p.A62S	ECE1_ENST00000436918.2_Missense_Mutation_p.A78S|ECE1_ENST00000374893.6_Missense_Mutation_p.A78S|ECE1_ENST00000357071.4_Missense_Mutation_p.A66S|ECE1_ENST00000264205.6_Missense_Mutation_p.A75S	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	78					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		ACCAGTCCTGCCGCCAGAAGT	0.637000													45	69					1.35964e-18	1.51826e-18	1	1	0
RP11-154H17.1	0	broad.mit.edu	37	1	5719022	5719022	+	RNA	DEL	C	C	-			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr1:5719022delC	ENST00000413887.1	-	0	155																											CCCCAGGACACCCCCCACTCC	0.632													2	4	---	---	---	---					
CYLD	1540	broad.mit.edu	37	16	50818322	50818323	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr16:50818322_50818323insA	ENST00000540145.1	+	12	2324_2325	c.1909_1910insA	c.(1909-1911)agafs	p.R637fs	CYLD_ENST00000311559.9_Frame_Shift_Ins_p.R637fs|CYLD_ENST00000569418.1_Frame_Shift_Ins_p.R634fs|CYLD_ENST00000427738.3_Frame_Shift_Ins_p.R637fs|RP11-327F22.4_ENST00000564510.1_RNA|CYLD_ENST00000564326.1_Frame_Shift_Ins_p.R634fs|RP11-327F22.4_ENST00000575917.1_RNA|CYLD_ENST00000568704.2_Frame_Shift_Ins_p.R452fs|CYLD_ENST00000398568.2_Frame_Shift_Ins_p.R634fs|CYLD_ENST00000566206.1_Frame_Shift_Ins_p.R634fs			Q9NQC7	CYLD_HUMAN	cylindromatosis (turban tumor syndrome)	637					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(9)|lung(17)|pancreas(1)|skin(22)|upper_aerodigestive_tract(1)	62		all_cancers(37;0.0156)				TAGTGAAACCCAAGAGCTACTG	0.347			"""Mis, N, F, S"""		cylindroma	cylindroma			Multiple Trichoepithelioma, Familial;Familial Cylindromatosis				62	48	---	---	---	---					
FFAR2	2867	broad.mit.edu	37	19	35940788	35940790	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-CN-A6UY-01A-12D-A34J-08	TCGA-CN-A6UY-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b15da5fe-21e9-4076-9350-3b1cc544e1e1	715962d9-fa9c-48bb-bf0b-e8afb62adfb2	g.chr19:35940788_35940790delCTG	ENST00000599180.1	+	2	252_254	c.172_174delCTG	c.(172-174)del	p.L62del	FFAR2_ENST00000601590.1_Intron|FFAR2_ENST00000246549.2_In_Frame_Del_p.L62del			O15552	FFAR2_HUMAN	free fatty acid receptor 2	62						integral to plasma membrane	G-protein coupled receptor activity|lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(6)|skin(1)|urinary_tract(1)	22	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CGACCTCCTCCTGCTGCTGCTGC	0.645													7	64	---	---	---	---					
