Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADD1	118	broad.mit.edu	37	4	2930158	2930158	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr4:2930158G>A	ENST00000264758.7	+	15	2403	c.2215G>A	c.(2215-2217)Gat>Aat	p.D739N	ADD1_ENST00000398129.1_Missense_Mutation_p.D708N|ADD1_ENST00000355842.3_3'UTR|ADD1_ENST00000398125.1_3'UTR|ADD1_ENST00000446856.1_Missense_Mutation_p.D708N|ADD1_ENST00000503455.2_3'UTR|ADD1_ENST00000398123.2_3'UTR|ADD1_ENST00000513328.2_3'UTR	NM_014189.3	NP_054908.2	P35611	ADDA_HUMAN	adducin 1 (alpha)	708					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCCTGGCAGCGATGGGTCTCC	0.632000													28	99					0	0	0.007291	0	0
AMER2	219287	broad.mit.edu	37	13	25744231	25744231	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr13:25744231C>T	ENST00000357816.2	-	3	1645	c.1170G>A	c.(1168-1170)ccG>ccA	p.P390P	AMER2_ENST00000515384.1_Silent_p.P509P|AMER2_ENST00000381853.3_Silent_p.P390P					APC membrane recruitment protein 2																		GCTCCTTCTCCGGGTGCTTGG	0.652000													18	65					0	0	0.006122	0	0
PEX19	5824	broad.mit.edu	37	1	160253344	160253344	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:160253344C>T	ENST00000368072.5	-	2	177	c.156G>A	c.(154-156)aaG>aaA	p.K52K	PEX19_ENST00000440949.3_5'UTR|PEX19_ENST00000532508.1_5'UTR|DCAF8_ENST00000556710.1_Intron	NM_001193644.1|NM_002857.3	NP_001180573.1|NP_002848.1			peroxisomal biogenesis factor 19											cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(2)	11	all_cancers(52;1.27e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTGGCGATCTCTTCTGGGGCC	0.577000													21	50					0	0	0.002780	0	0
TP53	7157	broad.mit.edu	37	17	7578196	7578196	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:7578196A>C	ENST00000420246.2	-	6	785	c.653T>G	c.(652-654)gTg>gGg	p.V218G	TP53_ENST00000413465.2_Missense_Mutation_p.V218G|TP53_ENST00000359597.4_Missense_Mutation_p.V218G|TP53_ENST00000455263.2_Missense_Mutation_p.V218G|TP53_ENST00000269305.4_Missense_Mutation_p.V218G|TP53_ENST00000445888.2_Missense_Mutation_p.V218G|TP53_ENST00000574684.1_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	218	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		V -> A (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(11)|p.V218E(8)|p.0?(8)|p.V218G(5)|p.V218del(5)|p.V218A(3)|p.D208fs*1(1)|p.V216fs*28(1)|p.V218fs*26(1)|p.S215_V218>R(1)|p.T211fs*28(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.S215fs*27(1)|p.V218_Y220delVPY(1)|p.V216_Y220delVVVPY(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCATAGGGCACCACCACACT	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	26					0	0	0.006214	0	0
ITPKC	80271	broad.mit.edu	37	19	41223543	41223543	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:41223543G>T	ENST00000263370.2	+	1	536	c.503G>T	c.(502-504)gGg>gTg	p.G168V		NM_025194.2	NP_079470.1	Q96DU7	IP3KC_HUMAN	inositol-trisphosphate 3-kinase C	168						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	14			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			ACACAGCCAGGGGTTCATGGG	0.607000													19	40					1.15919e-05	1.97672e-05	0.008871	1	0
FAT1	2195	broad.mit.edu	37	4	187522449	187522449	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr4:187522449G>A	ENST00000441802.2	-	21	11823	c.11614C>T	c.(11614-11616)Cga>Tga	p.R3872*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3872	Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TCAGTTCCTCGAGCATACATG	0.393000										HNSCC(5;0.00058)			11	27					0	0	0.001368	0	0
ACVR2A	92	broad.mit.edu	37	2	148653878	148653878	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr2:148653878C>G	ENST00000241416.7	+	2	700	c.64C>G	c.(64-66)Ctt>Gtt	p.L22V	ACVR2A_ENST00000404590.1_Missense_Mutation_p.L22V|ACVR2A_ENST00000535787.1_Intron	NM_001278579.1|NM_001278580.1|NM_001616.3	NP_001265508.1|NP_001265509.1|NP_001607.1	P27037	AVR2A_HUMAN	activin A receptor, type IIA	22					activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(5)|large_intestine(14)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(8)	45				BRCA - Breast invasive adenocarcinoma(221;0.0969)		AGGTGCTATACTTGGTAGATC	0.328000													7	49					0	0	0.001984	0	0
SRMS	6725	broad.mit.edu	37	20	62178520	62178520	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr20:62178520G>A	ENST00000217188.1	-	1	337	c.297C>T	c.(295-297)gcC>gcT	p.A99A		NM_080823.2	NP_543013.1	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	99	SH3.						ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|stomach(1)	19	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GCACGAGCCCGGCGCTGGGCT	0.697000													25	48					0	0	0.005443	0	0
LRRC6	23639	broad.mit.edu	37	8	133622423	133622423	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:133622423A>T	ENST00000519595.1	-	10	1227	c.1129T>A	c.(1129-1131)Tgc>Agc	p.C377S	LRRC6_ENST00000250173.1_Missense_Mutation_p.C377S|LRRC6_ENST00000518642.1_Missense_Mutation_p.C374S			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	377	CS.					cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TTGGGCATGCAGATGACCAAA	0.433000													12	78					0	0	0.001368	0	0
PDILT	204474	broad.mit.edu	37	16	20371931	20371931	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr16:20371931G>A	ENST00000302451.4	-	11	1713	c.1465C>T	c.(1465-1467)Ctg>Ttg	p.L489L		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	489					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						TGGCTTTCCAGGAAGTCAGAG	0.473000													50	190					0	0	0.003610	0	0
RIBC1	158787	broad.mit.edu	37	X	53455530	53455530	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:53455530C>T	ENST00000457095.1	+	5	703	c.499C>T	c.(499-501)Caa>Taa	p.Q167*	RIBC1_ENST00000375327.3_Nonsense_Mutation_p.Q167*|RIBC1_ENST00000490702.1_3'UTR|RIBC1_ENST00000414955.2_Intron	NM_144968.2	NP_659405.1	Q8N443	RIBC1_HUMAN	RIB43A domain with coiled-coils 1	167										lung(2)	2						CTTGGAAAGGCAACAGCAGGA	0.562000													15	9					0	0	0.003163	0	0
PNPLA7	375775	broad.mit.edu	37	9	140437130	140437130	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:140437130C>T	ENST00000406427.1	-	7	966	c.630G>A	c.(628-630)gtG>gtA	p.V210V	PNPLA7_ENST00000277531.4_Silent_p.V185V	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	185					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GCCCGTCCTGCACCACACAGA	0.642000													17	40					0	0	0.007413	0	0
DDX53	168400	broad.mit.edu	37	X	23019111	23019111	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:23019111G>T	ENST00000327968.5	+	1	1025	c.937G>T	c.(937-939)Gaa>Taa	p.E313*	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	313	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						TCTTCACGTGGAAGCTGAATG	0.398000													24	49					5.24475e-26	9.65511e-26	0.004656	1	0
POTEC	388468	broad.mit.edu	37	18	14530502	14530502	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr18:14530502G>C	ENST00000358970.5	-	6	1105	c.1106C>G	c.(1105-1107)tCt>tGt	p.S369C	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	369										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GTTTTCAGAAGAGATTTTTAG	0.303000													3	27					0	0	0.000248	0	0
ATG2B	55102	broad.mit.edu	37	14	96756776	96756776	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr14:96756776T>C	ENST00000359933.4	-	40	6746	c.5853A>G	c.(5851-5853)atA>atG	p.I1951M	ATG2B_ENST00000261834.5_5'UTR	NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1951										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AAGATACCTGTATGGTTTGAA	0.423000													23	65					0	0	0.002780	0	0
IGHV3OR16-9	28307	broad.mit.edu	37	16	33647430	33647430	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr16:33647430C>A	ENST00000558425.1	-	2	169	c.170G>T	c.(169-171)cGc>cTc	p.R57L																								TGGAGCCTGGCGGACCCAGCT	0.552000													63	249					2.6711e-34	4.94535e-34	0.003610	1	0
WSCD1	23302	broad.mit.edu	37	17	5993711	5993711	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:5993711G>A	ENST00000574946.1	+	4	1003	c.613G>A	c.(613-615)Gtg>Atg	p.V205M	WSCD1_ENST00000574232.1_Missense_Mutation_p.V205M|WSCD1_ENST00000573634.1_Missense_Mutation_p.V89M|WSCD1_ENST00000317744.5_Missense_Mutation_p.V205M|WSCD1_ENST00000539421.1_Missense_Mutation_p.V205M			Q658N2	WSCD1_HUMAN	WSC domain containing 1	205	WSC 1.					integral to membrane	sulfotransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						AGCGGTGAGCGTGGGGCTGGA	0.662000													17	59					0	0	0.004990	0	0
TBX22	50945	broad.mit.edu	37	X	79281179	79281179	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:79281179A>T	ENST00000442340.1	+	5	666	c.176A>T	c.(175-177)cAc>cTc	p.H59L	TBX22_ENST00000373296.3_Missense_Mutation_p.H179L|TBX22_ENST00000373291.1_Missense_Mutation_p.H59L|TBX22_ENST00000373294.5_Missense_Mutation_p.H179L	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	179					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TTCTATGTTCACCCGGACTCA	0.488000													25	71					0	0	0.002780	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651117	84651117	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr15:84651117C>T	ENST00000286744.5	+	21	2961	c.2737C>T	c.(2737-2739)Cgt>Tgt	p.R913C	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.R913C	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	913	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGAAGAGAAGCGTATTAACCT	0.473000													18	84					0	0	0.006122	0	0
LAGE3	8270	broad.mit.edu	37	X	153706741	153706741	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:153706741G>A	ENST00000357360.4	-	2	539	c.198C>T	c.(196-198)agC>agT	p.S66S	LAGE3_ENST00000407062.1_Silent_p.S66S	NM_006014.3	NP_006005.2	Q14657	LAGE3_HUMAN	L antigen family, member 3	66							protein binding			lung(2)	2	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGAAAGGCACGCTGAGGGTGC	0.602000													24	110					0	0	0.004656	0	0
C7	730	broad.mit.edu	37	5	40936557	40936557	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:40936557C>A	ENST00000313164.9	+	5	757	c.398C>A	c.(397-399)cCt>cAt	p.P133H		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	133	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				ATCGATAAACCTCCTCCTAAC	0.403000													17	26					6.94344e-10	1.21604e-09	0.006122	1	0
ATR	545	broad.mit.edu	37	3	142185265	142185265	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:142185265C>G	ENST00000350721.4	-	40	6919	c.6798G>C	c.(6796-6798)atG>atC	p.M2266I	ATR_ENST00000383101.3_Missense_Mutation_p.M2202I|RP11-383G6.3_ENST00000460977.1_RNA	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2266					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						GTGTAGGTATCATGACTGATT	0.403000								Other conserved DNA damage response genes					9	49					0	0	0.006214	0	0
ATP2A1	487	broad.mit.edu	37	16	28912067	28912067	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr16:28912067G>A	ENST00000395503.4	+	15	2114	c.1930G>A	c.(1930-1932)Gag>Aag	p.E644K	ATP2A1_ENST00000357084.3_Missense_Mutation_p.E644K|ATP2A1_ENST00000536376.1_Missense_Mutation_p.E519K	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	644					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						CATCTTTGGGGAGAACGAGGA	0.642000													15	64					0	0	0.003163	0	0
DNHD1	144132	broad.mit.edu	37	11	6588430	6588430	+	Missense_Mutation	SNP	T	T	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:6588430T>G	ENST00000254579.6	+	36	12255	c.11691T>G	c.(11689-11691)atT>atG	p.I3897M	DNHD1_ENST00000527990.2_Missense_Mutation_p.I3897M	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	3897					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CACGTGAGATTAATCACGGGG	0.572000													35	89					0	0	0.002836	0	0
PLA2G6	8398	broad.mit.edu	37	22	38508233	38508233	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr22:38508233C>T	ENST00000332509.3	-	17	2539	c.2356G>A	c.(2356-2358)Gag>Aag	p.E786K	PLA2G6_ENST00000335539.3_Missense_Mutation_p.E732K|PLA2G6_ENST00000402064.1_Missense_Mutation_p.E732K	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	786					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	ATGTAGACCTCGGTCTCCCAG	0.622000													4	14					0	0	0.000248	0	0
MYO6	4646	broad.mit.edu	37	6	76591501	76591501	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:76591501G>A	ENST00000369981.3	+	23	2661	c.2382G>A	c.(2380-2382)aaG>aaA	p.K794K	MYO6_ENST00000462633.1_3'UTR|MYO6_ENST00000369985.4_Silent_p.K794K|MYO6_ENST00000369977.3_Silent_p.K794K|MYO6_ENST00000369975.1_Silent_p.K794K			Q9UM54	MYO6_HUMAN	myosin VI	794	Required for binding calmodulin (By similarity).				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GTCGCTGGAAGAAAGTTCAGT	0.418000													23	77					0	0	0.003954	0	0
F13B	2165	broad.mit.edu	37	1	197030149	197030149	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:197030149A>T	ENST00000367412.1	-	4	551	c.508T>A	c.(508-510)Ttc>Atc	p.F170I		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	170	Sushi 3.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TTCACTTTGAATGTTTTCTGT	0.323000													13	61					0	0	0.001368	0	0
CPT1B	1375	broad.mit.edu	37	22	51010715	51010715	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr22:51010715G>C	ENST00000360719.2	-	12	1512	c.1375C>G	c.(1375-1377)Ctc>Gtc	p.L459V	CPT1B_ENST00000312108.7_Missense_Mutation_p.L459V|CPT1B_ENST00000440709.1_Missense_Mutation_p.L378V|CHKB-CPT1B_ENST00000453634.1_3'UTR|CPT1B_ENST00000405237.3_Missense_Mutation_p.L459V|CPT1B_ENST00000434492.2_Missense_Mutation_p.L256V|CPT1B_ENST00000457250.1_Missense_Mutation_p.L425V|CPT1B_ENST00000395650.2_Missense_Mutation_p.L459V	NM_001145135.1|NM_152245.2	NP_001138607.1|NP_689451.1	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B (muscle)	459					carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		AAGGAAATGAGAGTGAAGGAT	0.512000													8	39					0	0	0.003080	0	0
MYH13	8735	broad.mit.edu	37	17	10248895	10248895	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:10248895G>A	ENST00000418404.3	-	13	1465	c.1302C>T	c.(1300-1302)taC>taT	p.Y434Y	MYH13_ENST00000252172.4_Silent_p.Y434Y|MYH13_ENST00000570743.1_Silent_p.Y434Y			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	434	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						ACATCTTCTCGTAGACGGCTT	0.517000													36	125					0	0	0.003755	0	0
AFM	173	broad.mit.edu	37	4	74350097	74350097	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr4:74350097C>T	ENST00000226355.3	+	3	353	c.260C>T	c.(259-261)tCa>tTa	p.S87L		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	87	Albumin 1.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCAGAGTGTTCAAAATTACCT	0.343000													12	32					0	0	0.001368	0	0
ATG2A	23130	broad.mit.edu	37	11	64679357	64679357	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:64679357G>A	ENST00000421419.2	-	9	1299	c.1185C>T	c.(1183-1185)agC>agT	p.S395S	ATG2A_ENST00000377264.3_Silent_p.S395S			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	395							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						AGGCCATGTCGCTGCGCACAG	0.637000													5	24					0	0	0.000602	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:178936082G>A	ENST00000263967.3	+	10	1781	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	542	PI3K helical.		E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).|E -> V (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(545)|p.E542Q(10)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333000	E542K(BT483_BREAST)|E542K(CAL51_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(VMCUB1_URINARY_TRACT)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			11	43					0	0	0.001855	0	0
OR51Q1	390061	broad.mit.edu	37	11	5444060	5444060	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:5444060C>T	ENST00000300778.4	+	1	720	c.630C>T	c.(628-630)atC>atT	p.I210I	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCATTATTATCGTGGATCCTC	0.502000													39	119					0	0	0.006230	0	0
ENTPD4	9583	broad.mit.edu	37	8	23306270	23306270	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:23306270T>C	ENST00000358689.4	-	3	426	c.191A>G	c.(190-192)gAc>gGc	p.D64G	ENTPD4_ENST00000356206.6_Missense_Mutation_p.D64G|ENTPD4_ENST00000417069.2_Missense_Mutation_p.D64G	NM_001128930.2|NM_004901.4	NP_001122402.1|NP_004892.1	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	64					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	25		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		AAATTTCTTGTCTCTGGTTAG	0.378000													17	58					0	0	0.004007	0	0
KHSRP	8570	broad.mit.edu	37	19	6422368	6422368	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:6422368C>T	ENST00000398148.3	-	2	421	c.329G>A	c.(328-330)aGa>aAa	p.R110K		NM_003685.2	NP_003676.2	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	110	Gly-rich.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|liver(1)|lung(6)|skin(1)|soft_tissue(1)	17						TTCCAACTGTCTCTTTTGGCC	0.493000													19	96					0	0	0.008871	0	0
F9	2158	broad.mit.edu	37	X	138612944	138612944	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:138612944C>G	ENST00000218099.2	+	1	28	c.21C>G	c.(19-21)atC>atG	p.I7M	F9_ENST00000394090.2_Missense_Mutation_p.I7M|F9_ENST00000479617.1_3'UTR	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	7			I -> F.		blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TGAACATGATCATGGCAGAAT	0.413000													13	144					0	0	0.002450	0	0
GRIK1	2897	broad.mit.edu	37	21	31311810	31311810	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr21:31311810G>A	ENST00000399914.1	-	1	530	c.9C>T	c.(7-9)caC>caT	p.H3H	GRIK1_ENST00000389124.2_Silent_p.H3H|GRIK1_ENST00000399913.1_Silent_p.H3H|GRIK1_ENST00000309434.7_Silent_p.H3H|GRIK1_ENST00000327783.4_Silent_p.H3H|GRIK1_ENST00000535441.1_Silent_p.H3H|GRIK1_ENST00000389125.3_Silent_p.H3H|GRIK1_ENST00000399907.1_Silent_p.H3H|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000399909.1_Silent_p.H3H			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	3					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GGAGTGTGCCGTGCTCCATCT	0.622000													4	10					0	0	0.000248	0	0
C1orf173	127254	broad.mit.edu	37	1	75038225	75038225	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:75038225C>A	ENST00000326665.5	-	14	3387	c.3169G>T	c.(3169-3171)Gca>Tca	p.A1057S	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1057	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CGCTCTCTTGCTAAATCTAAT	0.443000													51	131					2.0833e-19	3.77089e-19	0.003610	1	0
DHRS7	51635	broad.mit.edu	37	14	60616104	60616104	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr14:60616104C>T	ENST00000216500.5	-	7	1394	c.939G>A	c.(937-939)ggG>ggA	p.G313G	DHRS7_ENST00000536410.2_Silent_p.G263G|PCNXL4_ENST00000553898.1_Intron|DHRS7_ENST00000557185.1_Silent_p.G313G|PCNXL4_ENST00000406949.1_Intron			Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	313							binding|oxidoreductase activity			endometrium(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	5				OV - Ovarian serous cystadenocarcinoma(108;0.121)		TCCTTTTCTTCCCCATCTTGT	0.383000													15	56					0	0	0.003163	0	0
CREB3L3	84699	broad.mit.edu	37	19	4164536	4164536	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:4164536C>T	ENST00000078445.2	+	5	760	c.613C>T	c.(613-615)Cct>Tct	p.P205S	CREB3L3_ENST00000252587.3_Missense_Mutation_p.P145S|CREB3L3_ENST00000595923.1_Missense_Mutation_p.P204S|CREB3L3_ENST00000602147.1_Missense_Mutation_p.P205S|CREB3L3_ENST00000602257.1_Missense_Mutation_p.P203S	NM_001271995.1|NM_001271996.1|NM_032607.1	NP_001258924.1|NP_001258925.1|NP_115996.1	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like 3	205					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|urinary_tract(3)	24				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCCTGCGACCTGGGGCTGG	0.582000													19	94					0	0	0.001523	0	0
USP29	57663	broad.mit.edu	37	19	57640945	57640945	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:57640945A>C	ENST00000254181.4	+	4	1356	c.902A>C	c.(901-903)cAa>cCa	p.Q301P	USP29_ENST00000598197.1_Missense_Mutation_p.Q301P	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	301					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCAGTTTTACAATCGCTATTT	0.448000													7	58					0	0	0.001984	0	0
NAP1L2	4674	broad.mit.edu	37	X	72433920	72433920	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:72433920C>T	ENST00000373517.3	-	1	764	c.409G>A	c.(409-411)Gaa>Aaa	p.E137K	NAP1L2_ENST00000536638.1_5'UTR	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	137					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					AACTTTCTTTCAATGTCATGA	0.373000													29	99					0	0	0.006320	0	0
C17orf53	78995	broad.mit.edu	37	17	42226342	42226342	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:42226342A>C	ENST00000319977.4	+	3	1408	c.1171A>C	c.(1171-1173)Acc>Ccc	p.T391P	C17orf53_ENST00000245382.6_Missense_Mutation_p.T391P|C17orf53_ENST00000585683.1_Missense_Mutation_p.T391P	NM_001171251.1|NM_024032.3	NP_001164722.1|NP_076937.2	Q8N3J3	CQ053_HUMAN	chromosome 17 open reading frame 53	391										NS(1)|breast(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	22		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CCATCCCTCCACCCGAGCCAA	0.622000													9	83					0	0	0.006122	0	0
DNTTIP1	116092	broad.mit.edu	37	20	44422617	44422617	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr20:44422617C>T	ENST00000372622.3	+	3	302	c.234C>T	c.(232-234)atC>atT	p.I78I		NM_052951.2	NP_443183.1	Q9H147	TDIF1_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 1	78						nucleus				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)	9		Myeloproliferative disorder(115;0.0122)				AGCCCAGCATCAACGAGGAGA	0.522000													19	65					0	0	0.003330	0	0
CD82	3732	broad.mit.edu	37	11	44640601	44640601	+	Silent	SNP	C	C	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:44640601C>A	ENST00000227155.4	+	10	977	c.729C>A	c.(727-729)ctC>ctA	p.L243L	CD82_ENST00000342935.3_Silent_p.L218L|CD82_ENST00000530931.1_3'UTR	NM_002231.3	NP_002222.1	P27701	CD82_HUMAN	CD82 molecule	243						integral to plasma membrane	protein binding			large_intestine(1)|ovary(1)	2						CCCCACAGCTCCTGGGGATGG	0.607000													14	57					6.94344e-10	1.21604e-09	0.006122	1	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240729	39240729	+	Missense_Mutation	SNP	A	A	G	rs148949542	by1000genomes	TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:39240729A>G	ENST00000391417.4	+	1	271	c.271A>G	c.(271-273)Atg>Gtg	p.M91V		NM_033061.3	NP_149050.3			keratin associated protein 4-7											NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						cagctgctgtatgtccagctg	0.677000													3	60					0	0	0.001168	0	0
PNMA5	114824	broad.mit.edu	37	X	152159807	152159807	+	Silent	SNP	A	A	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:152159807A>G	ENST00000439251.1	-	2	774	c.336T>C	c.(334-336)gaT>gaC	p.D112D	PNMA5_ENST00000452693.1_Silent_p.D112D|PNMA5_ENST00000361887.5_Silent_p.D112D|PNMA5_ENST00000535214.1_Silent_p.D112D	NM_001103150.1	NP_001096620.1	Q96PV4	PNMA5_HUMAN	paraneoplastic Ma antigen family member 5	112					apoptosis					breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					ttcggccctcatctttcagga	0.547000													46	241					0	0	0.003610	0	0
HIST1H2BG	8339	broad.mit.edu	37	6	26216707	26216707	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:26216707G>C	ENST00000244601.3	-	1	165	c.165C>G	c.(163-165)atC>atG	p.I55M		NM_003518.3	NP_003509.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	55					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	8		all_hematologic(11;0.196)				CCTTGGATGAGATGCCAGTAT	0.537000													39	206					0	0	0.004878	0	0
MYO9B	4650	broad.mit.edu	37	19	17270248	17270248	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:17270248C>T	ENST00000595618.1	+	8	1525	c.1373C>T	c.(1372-1374)aCg>aTg	p.T458M	CTD-3032J10.2_ENST00000599360.1_RNA|CTD-3032J10.2_ENST00000597216.1_RNA|MYO9B_ENST00000594824.1_Missense_Mutation_p.T458M|MYO9B_ENST00000397274.2_Missense_Mutation_p.T458M	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	458	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity	p.T458M(2)		breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						AAAAGAAAAACGGTGACCGTC	0.522000													6	13					0	0	0.001984	0	0
LRRC7	57554	broad.mit.edu	37	1	70144160	70144160	+	Splice_Site	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:70144160G>C	ENST00000370958.1	+	2	289	c.100_splice	c.e2+1	p.E33_splice	LRRC7_ENST00000310961.5_5'UTR			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	0						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CTGAAGAGGAGTGTAAGTATG	0.408000													5	12					0	0	0.000602	0	0
TMEM138	51524	broad.mit.edu	37	11	61133693	61133693	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:61133693G>C	ENST00000542946.1	+	3	504	c.305G>C	c.(304-306)aGa>aCa	p.R102T	TMEM138_ENST00000381787.2_Intron|TMEM138_ENST00000540194.1_Intron|TMEM138_ENST00000278826.6_Intron			Q9NPI0	TM138_HUMAN	transmembrane protein 138	0						integral to membrane				central_nervous_system(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5						GTCATGGTAAGAGTGGCAGTC	0.438000													28	91					0	0	0.005443	0	0
CHD8	57680	broad.mit.edu	37	14	21881157	21881157	+	Splice_Site	SNP	T	T	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr14:21881157T>C	ENST00000399982.2	-	9	2207		c.e9-2		CHD8_ENST00000557364.1_Splice_Site|CHD8_ENST00000555962.1_Intron|CHD8_ENST00000430710.3_Splice_Site	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8						ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CTCTTCATCCTAGATGAGTTA	0.423000													6	20					0	0	0.001168	0	0
FYCO1	79443	broad.mit.edu	37	3	46008282	46008282	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:46008282G>A	ENST00000296137.2	-	8	2749	c.2544C>T	c.(2542-2544)tgC>tgT	p.C848C	FYCO1_ENST00000535325.1_Silent_p.C848C	NM_024513.3	NP_078789.2	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	848					transport	integral to membrane	metal ion binding|protein binding			NS(4)|breast(3)|central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(17)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	54				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		CACGCTCCGAGCATTGCAGCA	0.627000													11	24					0	0	0.000978	0	0
C9orf3	84909	broad.mit.edu	37	9	97522832	97522832	+	Missense_Mutation	SNP	C	C	T	rs145414026		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:97522832C>T	ENST00000375315.2	+	1	767	c.767C>T	c.(766-768)tCg>tTg	p.S256L	C9orf3_ENST00000297979.5_Missense_Mutation_p.S256L|C9orf3_ENST00000277198.2_Missense_Mutation_p.S256L	NM_001193329.1	NP_001180258.1	Q8N6M6	AMPO_HUMAN	chromosome 9 open reading frame 3	256					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		GAAGGGCGATCGGTTACATGG	0.488000													5	18					0	0	0.001168	0	0
KRT74	121391	broad.mit.edu	37	12	52965209	52965209	+	Silent	SNP	C	C	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:52965209C>A	ENST00000549343.1	-	4	815	c.777G>T	c.(775-777)gtG>gtT	p.V259V	KRT74_ENST00000305620.2_Silent_p.V259V			Q7RTS7	K2C74_HUMAN	keratin 74	259	Coil 1B.|Rod.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		CCTGAAGCTCCACCTTGACTG	0.567000													16	54					1.99824e-07	3.46218e-07	0.004990	1	0
KCNN2	3781	broad.mit.edu	37	5	113831673	113831673	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:113831673A>G	ENST00000512097.3	+	9	2552	c.1534A>G	c.(1534-1536)Aca>Gca	p.T512A	KCNN2_ENST00000264773.3_Missense_Mutation_p.T512A|KCNN2_ENST00000503706.1_Missense_Mutation_p.T164A|RP11-492A10.1_ENST00000514115.1_RNA			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	512						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TACCCTGGAAACAAAACTAGA	0.448000													20	116					0	0	0.001882	0	0
CEP95	90799	broad.mit.edu	37	17	62533807	62533807	+	Silent	SNP	T	T	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:62533807T>C	ENST00000556440.2	+	20	2886	c.2376T>C	c.(2374-2376)gaT>gaC	p.D792D	CEP95_ENST00000553412.1_Silent_p.D628D	NM_138363.1	NP_612372.1	Q96GE4	CEP95_HUMAN	centrosomal protein 95kDa	792						centrosome|spindle pole	protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)	13						AGAATGATGATGATGTTTTCT	0.458000													6	27					0	0	0.001168	0	0
TMCO1	54499	broad.mit.edu	37	1	165712477	165712477	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:165712477T>C	ENST00000367881.5	-	6	823	c.548A>G	c.(547-549)aAt>aGt	p.N183S	TMCO1_ENST00000464650.1_Missense_Mutation_p.N48S|TMCO1_ENST00000392129.6_Missense_Mutation_p.N132S|TMCO1_ENST00000580248.1_Missense_Mutation_p.N48S			Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1	132	Poly-Pro.					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					TCCCAGCAGATTTCGATGAGA	0.378000													14	43					0	0	0.004007	0	0
ZNF432	9668	broad.mit.edu	37	19	52537191	52537191	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:52537191C>A	ENST00000594154.1	-	5	1953	c.1741G>T	c.(1741-1743)Gaa>Taa	p.E581*	ZNF432_ENST00000221315.5_Nonsense_Mutation_p.E581*			O94892	ZN432_HUMAN	zinc finger protein 432	581					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	29		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		AGCTCTGTTTCCTTGGCAAAG	0.378000													28	63					9.39395e-14	1.69091e-13	0.006320	1	0
PCNXL3	399909	broad.mit.edu	37	11	65397860	65397860	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:65397860G>A	ENST00000355703.3	+	27	4794	c.4255G>A	c.(4255-4257)Gag>Aag	p.E1419K		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1419						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						GGCTATCACCGAGGGTGTGGA	0.637000													24	67					0	0	0.003330	0	0
CHUK	1147	broad.mit.edu	37	10	101953836	101953836	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:101953836C>A	ENST00000370397.7	-	18	1965	c.1879G>T	c.(1879-1881)Gtg>Ttg	p.V627L	CHUK_ENST00000590930.1_5'UTR	NM_001278.3	NP_001269.3	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	627					I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	27		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		CTGAGGGCCACTTCCACCTTA	0.423000													13	52					0.00010058	0.000170617	0.001368	1	0
ABHD15	116236	broad.mit.edu	37	17	27889938	27889938	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:27889938C>A	ENST00000307201.4	-	2	1218	c.1048G>T	c.(1048-1050)Gtg>Ttg	p.V350L	RP11-68I3.2_ENST00000581474.1_RNA	NM_198147.2	NP_937790.2	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15	350						extracellular region	carboxylesterase activity			breast(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	10						AGCACAGGCACGGCTGCCTCA	0.582000													7	47					0.000673444	0.00113055	0.008291	1	0
KIAA2026	158358	broad.mit.edu	37	9	5922609	5922609	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:5922609C>T	ENST00000399933.3	-	8	3386	c.3387G>A	c.(3385-3387)caG>caA	p.Q1129Q	KIAA2026_ENST00000381461.2_Silent_p.Q1099Q	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1129										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CTGTACCTTTCTGTTGAAGTG	0.368000													4	83					0	0	0.000248	0	0
SNHG14	104472715	broad.mit.edu	37	15	25457050	25457050	+	RNA	SNP	G	G	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr15:25457050G>T	ENST00000424208.1	+	0	2516				SNHG14_ENST00000450809.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						TTTGGAGGAGGATGCTGGGAT	0.507000													58	142					8.4772e-36	1.57851e-35	0.003610	1	0
ZSCAN1	284312	broad.mit.edu	37	19	58565265	58565265	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:58565265G>A	ENST00000282326.1	+	6	1320	c.1073G>A	c.(1072-1074)cGg>cAg	p.R358Q		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	358					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AAGGGCCCCCGGGAGTCCGTC	0.662000													10	37					0	0	0.000978	0	0
CELSR3	1951	broad.mit.edu	37	3	48697921	48697921	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:48697921C>T	ENST00000544264.1	-	1	2427	c.2147G>A	c.(2146-2148)cGt>cAt	p.R716H	CELSR3_ENST00000164024.4_Missense_Mutation_p.R716H			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	716	Cadherin 4.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CACAGACTCACGGTCCAGGGG	0.557000													12	26					0	0	0.000978	0	0
FER1L6	654463	broad.mit.edu	37	8	125094566	125094566	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:125094566C>T	ENST00000522917.1	+	33	4464	c.4258C>T	c.(4258-4260)Ctg>Ttg	p.L1420L	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Silent_p.L1420L	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1420	C2 5.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAAAGAGTCCCTGCTCTCCAT	0.488000													43	149					0	0	0.008740	0	0
WDR17	116966	broad.mit.edu	37	4	177071078	177071078	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr4:177071078G>C	ENST00000393643.2	+	14	2270	c.2018G>C	c.(2017-2019)aGa>aCa	p.R673T	WDR17_ENST00000280190.4_Missense_Mutation_p.R697T|WDR17_ENST00000508596.1_Missense_Mutation_p.R673T|WDR17_ENST00000507824.2_Missense_Mutation_p.R680T	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	697										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		CTGGCAGACAGATCTTGGGAA	0.383000													3	83					0	0	0.004672	0	0
UAP1	6675	broad.mit.edu	37	1	162536139	162536139	+	Splice_Site	SNP	G	G	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:162536139G>T	ENST00000271469.3	+	2	582		c.e2+1		UAP1_ENST00000367924.1_Splice_Site|UAP1_ENST00000367925.1_Splice_Site|UAP1_ENST00000367926.4_Splice_Site			Q16222	UAP1_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1						dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			breast(2)|cervix(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)|skin(2)|stomach(1)	22	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			GAAAGTGAAGGTACTGGGCAT	0.408000													12	31					2.68362e-12	4.80383e-12	0.001368	1	0
CWF19L2	143884	broad.mit.edu	37	11	107197637	107197637	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:107197637C>T	ENST00000282251.5	-	18	2711	c.2684G>A	c.(2683-2685)tGa>tAa	p.*895*		NM_152434.2	NP_689647.2	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control (S. pombe)	0							catalytic activity			endometrium(4)|kidney(2)|large_intestine(13)|lung(21)	40		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		AGGTACACCTCAATAGTTTTT	0.408000													11	42					0	0	0.000978	0	0
PI4KAP2	375133	broad.mit.edu	37	22	21828938	21828938	+	RNA	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr22:21828938C>T	ENST00000450651.1	-	0	1870																				endometrium(3)|urinary_tract(1)	4						TTTGCAGCCTCGCGCTCAGTC	0.637000													6	16					0	0	0.004482	0	0
SLC8A1	6546	broad.mit.edu	37	2	40366549	40366549	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr2:40366549G>C	ENST00000406785.1	-	7	2618	c.2429C>G	c.(2428-2430)tCa>tGa	p.S810*	SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1_ENST00000332839.4_Nonsense_Mutation_p.S846*|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1_ENST00000406391.2_Nonsense_Mutation_p.S810*|SLC8A1_ENST00000408028.2_Nonsense_Mutation_p.S838*|SLC8A1_ENST00000405901.3_Nonsense_Mutation_p.S841*|SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1_ENST00000542024.1_Nonsense_Mutation_p.S810*|SLC8A1_ENST00000402441.1_Nonsense_Mutation_p.S810*|SLC8A1_ENST00000403092.1_Nonsense_Mutation_p.S846*|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1_ENST00000405269.1_Nonsense_Mutation_p.S810*|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1_ENST00000542756.1_Nonsense_Mutation_p.S841*|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1-AS1_ENST00000599956.1_RNA			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	846					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	ACCTGGCACTGATGTTCCAAG	0.453000													10	20					0	0	0.000978	0	0
MIB1	57534	broad.mit.edu	37	18	19429197	19429197	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr18:19429197G>C	ENST00000261537.6	+	17	2698	c.2434G>C	c.(2434-2436)Gat>Cat	p.D812H	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	812					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding	p.D812Y(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			GATTAGTAATGATTCTGAAAC	0.348000													47	198					0	0	0.003610	0	0
NFATC2	4773	broad.mit.edu	37	20	50007976	50007976	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr20:50007976A>G	ENST00000396009.3	-	10	2954	c.2735T>C	c.(2734-2736)aTc>aCc	p.I912T	NFATC2_ENST00000414705.1_3'UTR|NFATC2_ENST00000371564.3_3'UTR	NM_001258292.1|NM_001258295.1|NM_001258297.1|NM_173091.3	NP_001245221.1|NP_001245224.1|NP_001245226.1|NP_775114.1	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	912					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					CTCCTTCCTGATAATTTCATT	0.483000													25	63					0	0	0.004656	0	0
CRLS1	54675	broad.mit.edu	37	20	5990553	5990553	+	Missense_Mutation	SNP	G	G	C	rs59962100		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr20:5990553G>C	ENST00000378863.4	+	2	596	c.439G>C	c.(439-441)Gat>Cat	p.D147H	CRLS1_ENST00000452938.1_Missense_Mutation_p.D147H|CRLS1_ENST00000378868.3_Missense_Mutation_p.D48H	NM_019095.4	NP_061968.1	Q9UJA2	CRLS1_HUMAN	cardiolipin synthase 1	147					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphotransferase activity, for other substituted phosphate groups			lung(3)|ovary(1)	4						TGGACTAACAGATTTGGTAAG	0.413000													5	51					0	0	0.000602	0	0
LRRC37BP1	147172	broad.mit.edu	37	17	28958878	28958878	+	RNA	SNP	C	C	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:28958878C>G	ENST00000412831.1	+	0	106				SMURF2P1_ENST00000578265.1_RNA																							GAGGCGCCCTCAGACAGCAGT	0.502000													77	272					0	0	0.003610	0	0
FNIP2	57600	broad.mit.edu	37	4	159753081	159753081	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr4:159753081C>T	ENST00000264433.6	+	4	525	c.450C>T	c.(448-450)taC>taT	p.Y150Y	FNIP2_ENST00000379346.3_Silent_p.Y173Y	NM_020840.1	NP_065891.1	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	150					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		CCATGAGTTACAAAGGCTCCA	0.408000													5	15					0	0	0.000602	0	0
PLXNB2	23654	broad.mit.edu	37	22	50716549	50716549	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr22:50716549G>A	ENST00000449103.1	-	31	5024	c.4884C>T	c.(4882-4884)gtC>gtT	p.V1628V	PLXNB2_ENST00000359337.4_Silent_p.V1628V			O15031	PLXB2_HUMAN	plexin B2	1628					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGCCCACCTTGACTGAGAGCA	0.687000													7	25					0	0	0.001984	0	0
IRF7	3665	broad.mit.edu	37	11	613301	613301	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:613301C>T	ENST00000397566.1	-	7	1590	c.1181G>A	c.(1180-1182)gGc>gAc	p.G394D	IRF7_ENST00000397574.2_Missense_Mutation_p.G381D|IRF7_ENST00000348655.6_Missense_Mutation_p.G352D|IRF7_ENST00000330243.5_Missense_Mutation_p.G394D|IRF7_ENST00000397562.3_Missense_Mutation_p.G88D|IRF7_ENST00000397570.1_Missense_Mutation_p.G352D|IRF7_ENST00000525445.1_Missense_Mutation_p.G275D	NM_004031.2	NP_004022.2	Q92985	IRF7_HUMAN	interferon regulatory factor 7	381					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGGGGGTCCGCCCACCTCCCA	0.672000													7	27					0	0	0.003080	0	0
ATP8A2	51761	broad.mit.edu	37	13	26104781	26104781	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr13:26104781G>A	ENST00000381655.2	+	4	545	c.403G>A	c.(403-405)Gag>Aag	p.E135K	ATP8A2_ENST00000255283.8_Missense_Mutation_p.E95K	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	95					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AGGCATCAAAGAGATTGTAGA	0.353000													4	16					0	0	0.000248	0	0
ZNF710	374655	broad.mit.edu	37	15	90611533	90611533	+	Silent	SNP	C	C	T	rs144375764		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr15:90611533C>T	ENST00000268154.4	+	2	1415	c.1164C>T	c.(1162-1164)ttC>ttT	p.F388F		NM_198526.2	NP_940928.2	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(1)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	19	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			GCCGCGGCTTCGCCTACCCCA	0.642000													13	46					0	0	0.004007	0	0
TRPM6	140803	broad.mit.edu	37	9	77377455	77377455	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:77377455C>T	ENST00000451710.3	-	26	4369	c.4132G>A	c.(4132-4134)Gac>Aac	p.D1378N	TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000360774.1_Missense_Mutation_p.D1378N|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Missense_Mutation_p.D1373N|TRPM6_ENST00000376864.4_Missense_Mutation_p.D1378N|TRPM6_ENST00000449912.2_Missense_Mutation_p.D1373N			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1378					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity	p.D1378Y(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GTCTGGATGTCCTGTTCAGTT	0.512000													26	89					0	0	0.003954	0	0
DOCK5	80005	broad.mit.edu	37	8	25267635	25267635	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:25267635G>A	ENST00000276440.7	+	51	5469	c.5425G>A	c.(5425-5427)Gat>Aat	p.D1809N		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1809	Pro-rich.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GTTGCAGACAGATGGAATCGC	0.552000													9	17					0	0	0.008291	0	0
DRAM2	128338	broad.mit.edu	37	1	111660792	111660792	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:111660792C>T	ENST00000286692.4	-	9	1408	c.791G>A	c.(790-792)aGa>aAa	p.R264K	DRAM2_ENST00000539140.1_Missense_Mutation_p.R264K|DRAM2_ENST00000484310.1_5'UTR			Q6UX65	DRAM2_HUMAN	DNA-damage regulated autophagy modulator 2	264					apoptosis|induction of apoptosis	Golgi apparatus|integral to membrane|lysosomal membrane				endometrium(1)|large_intestine(5)|lung(3)	9						TCAAATATCTCTGGAAAGTAG	0.368000													10	53					0	0	0.008291	0	0
PCED1A	64773	broad.mit.edu	37	20	2819570	2819570	+	Silent	SNP	A	A	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr20:2819570A>C	ENST00000360652.2	-	4	865	c.363T>G	c.(361-363)ctT>ctG	p.L121L	PCED1A_ENST00000356872.3_Silent_p.L70L	NM_022760.3	NP_073597.2			PC-esterase domain containing 1A																		GAACATCCTCAAGGTACTCGG	0.577000													5	94					0	0	0.001168	0	0
TBX20	57057	broad.mit.edu	37	7	35244106	35244106	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr7:35244106C>T	ENST00000408931.3	-	7	1505	c.979G>A	c.(979-981)Gag>Aag	p.E327K		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	327						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						GTCTGACTCTCATCCCCCAAG	0.512000													10	36					0	0	0.006214	0	0
SUV420H1	51111	broad.mit.edu	37	11	67925548	67925548	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:67925548G>A	ENST00000304363.4	-	11	2618	c.2265C>T	c.(2263-2265)aaC>aaT	p.N755N		NM_017635.3	NP_060105.3	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	755					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						CATAGAGATTGTTATCGTTGT	0.368000													58	152					0	0	0.003610	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501700	140501700	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:140501700C>T	ENST00000194152.1	+	1	120	c.120C>T	c.(118-120)agC>agT	p.S40S		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		40	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAACAGAGAGCGGCTCCTTTG	0.537000													11	57					0	0	0.001368	0	0
SPATA9	83890	broad.mit.edu	37	5	94994576	94994576	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:94994576G>C	ENST00000274432.8	-	5	657	c.516C>G	c.(514-516)atC>atG	p.I172M	SPATA9_ENST00000477047.2_5'UTR|RFESD_ENST00000508206.1_Intron	NM_031952.3	NP_114158.2	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	172					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				large_intestine(3)|lung(4)	7		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		CTTCCTGGAAGATGTTCTTTA	0.383000													12	53					0	0	0.001368	0	0
CSPP1	79848	broad.mit.edu	37	8	68028171	68028171	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:68028171G>T	ENST00000262210.5	+	11	1326	c.1295G>T	c.(1294-1296)aGt>aTt	p.S432I	CSPP1_ENST00000412460.1_Missense_Mutation_p.S138I	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	467						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AAGCAGTTTAGTGTGGCACCA	0.413000													14	81					4.3838e-07	7.55506e-07	0.001855	1	0
SNHG14	104472715	broad.mit.edu	37	15	25325330	25325330	+	RNA	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr15:25325330G>A	ENST00000549804.2	+	0	1377				SNORD116-14_ENST00000383894.1_RNA																							TTGGAAAGCTGAACAAAATGA	0.438000													26	137					0	0	0.004656	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960449	73960449	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:73960449C>A	ENST00000373468.1	-	3	4594	c.3943G>T	c.(3943-3945)Gag>Tag	p.E1315*	KIAA2022_ENST00000055682.5_Nonsense_Mutation_p.E1315*			Q5QGS0	K2022_HUMAN	KIAA2022	1315					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TAGGAAGGCTCCTGAAATTCC	0.532000													37	110					6.99958e-10	1.21928e-09	0.006999	1	0
GRID1	2894	broad.mit.edu	37	10	87898641	87898641	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:87898641G>A	ENST00000327946.7	-	4	746	c.661C>T	c.(661-663)Cgg>Tgg	p.R221W		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	221						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	AGCGTGTCCCGGTAGCGATTC	0.592000										Multiple Myeloma(13;0.14)			41	133					0	0	0.002222	0	0
BRINP1	1620	broad.mit.edu	37	9	121929788	121929788	+	Silent	SNP	A	A	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:121929788A>T	ENST00000265922.3	-	8	2321	c.1860T>A	c.(1858-1860)cgT>cgA	p.R620R	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		620					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						GAGTCCGACTACGTAGGTAGA	0.537000													33	107					0	0	0.002445	0	0
KCNK18	338567	broad.mit.edu	37	10	118969311	118969311	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:118969311C>G	ENST00000334549.1	+	3	656	c.656C>G	c.(655-657)tCa>tGa	p.S219*		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	219						integral to membrane|plasma membrane		p.S219L(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		ACATGTCCTTCACGCCCAAGC	0.532000													14	51					0	0	0.003163	0	0
NTRK3	4916	broad.mit.edu	37	15	88799155	88799155	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr15:88799155G>C	ENST00000394480.1	-	3	551	c.230C>G	c.(229-231)tCa>tGa	p.S77*	NTRK3_ENST00000558676.1_Nonsense_Mutation_p.S77*|NTRK3-AS1_ENST00000569588.1_lincRNA|NTRK3_ENST00000557856.1_Nonsense_Mutation_p.S77*|NTRK3_ENST00000355254.2_Nonsense_Mutation_p.S77*|NTRK3_ENST00000540489.2_Nonsense_Mutation_p.S77*|NTRK3_ENST00000360948.2_Nonsense_Mutation_p.S77*|NTRK3_ENST00000317501.3_Nonsense_Mutation_p.S77*|NTRK3_ENST00000357724.2_Nonsense_Mutation_p.S77*	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	77					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GATATTCCTTGAGATGTCCGT	0.647000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			19	60					0	0	0.008871	0	0
AGAP11	119385	broad.mit.edu	37	10	88768495	88768495	+	RNA	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:88768495G>A	ENST00000444431.1	+	0	3095				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										GTGATTATATGAAGAATATTC	0.443000													55	197					0	0	0.003610	0	0
MIR656	724026	broad.mit.edu	37	14	101533123	101533123	+	RNA	SNP	T	T	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr14:101533123T>C	ENST00000385224.1	+	0	63					NR_030392.1																						AGTCAACCTCTTTCCGATATC	0.502000													25	72					0	0	0.002780	0	0
INPP4A	3631	broad.mit.edu	37	2	99154409	99154409	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr2:99154409C>T	ENST00000074304.5	+	8	944	c.551C>T	c.(550-552)aCc>aTc	p.T184I	INPP4A_ENST00000409851.3_Missense_Mutation_p.T184I|INPP4A_ENST00000409540.3_Missense_Mutation_p.T184I|INPP4A_ENST00000409016.3_Missense_Mutation_p.T184I|INPP4A_ENST00000409463.1_Intron|INPP4A_ENST00000545415.1_Missense_Mutation_p.T184I|INPP4A_ENST00000523221.1_Missense_Mutation_p.T184I	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	184					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						CCCCCTGTGACCCGGTCTGTG	0.522000													5	16					0	0	0.000602	0	0
BRWD3	254065	broad.mit.edu	37	X	79946660	79946660	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:79946660G>C	ENST00000373275.4	-	31	3710	c.3494C>G	c.(3493-3495)cCt>cGt	p.P1165R	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1165	Bromo 1.									breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						AACAGCAAAAGGGCTGGCAAA	0.373000													14	30					0	0	0.002450	0	0
SH3TC2	79628	broad.mit.edu	37	5	148386619	148386619	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:148386619A>G	ENST00000515425.1	-	16	3601	c.3500T>C	c.(3499-3501)gTg>gCg	p.V1167A	SH3TC2_ENST00000512049.1_Missense_Mutation_p.V1160A|SH3TC2_ENST00000538184.1_Silent_p.G711G|SH3TC2_ENST00000502274.1_Missense_Mutation_p.V29A	NM_024577.3	NP_078853.2	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1167							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGAAAGGCCACCAGCTCTTG	0.488000													18	80					0	0	0.006122	0	0
LGSN	51557	broad.mit.edu	37	6	63989944	63989944	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:63989944G>A	ENST00000370657.4	-	4	1545	c.1512C>T	c.(1510-1512)ttC>ttT	p.F504F	LGSN_ENST00000370658.5_3'UTR			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	504					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	AATACTCTAAGAATTTATTTC	0.328000													9	55					0	0	0.006214	0	0
EXTL1	2134	broad.mit.edu	37	1	26349593	26349593	+	Silent	SNP	A	A	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:26349593A>G	ENST00000374280.3	+	1	1323	c.456A>G	c.(454-456)caA>caG	p.Q152Q		NM_004455.2	NP_004446.2	Q92935	EXTL1_HUMAN	exostosin-like glycosyltransferase 1	152					skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|stomach(1)|urinary_tract(1)	23		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		TGCCTCTGCAATGGAACAGGG	0.647000													13	53					0	0	0.001368	0	0
PDZD8	118987	broad.mit.edu	37	10	119043299	119043299	+	Missense_Mutation	SNP	G	G	A	rs148717941		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:119043299G>A	ENST00000334464.5	-	5	3184	c.2945C>T	c.(2944-2946)aCg>aTg	p.T982M		NM_173791.3	NP_776152.1	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	982					intracellular signal transduction		metal ion binding			kidney(3)|large_intestine(8)|lung(24)|upper_aerodigestive_tract(3)	38		Colorectal(252;0.19)		all cancers(201;0.0121)		ACAGACCTCCGTGTCACTGCC	0.478000													79	257					0	0	0.003610	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55281317	55281317	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:55281317C>T	ENST00000336077.6	+	1	55	c.15C>T	c.(13-15)gtC>gtT	p.V5V	KIR2DL4_ENST00000396284.2_Intron|KIR2DL1_ENST00000291633.7_Silent_p.V5V|KIR3DL1_ENST00000541392.1_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000402254.2_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	5			V -> F (in dbSNP:rs2304224).		immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		CGCTCTTGGTCGTCAGCATGG	0.602000											OREG0003674	type=REGULATORY REGION|Gene=KIR2DL1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	32	37					0	0	0.002836	0	0
NBPF1	55672	broad.mit.edu	37	1	16907926	16907926	+	Silent	SNP	T	T	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:16907926T>A	ENST00000430580.2	-	15	2255	c.1368A>T	c.(1366-1368)tcA>tcT	p.S456S		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	456	NBPF 2.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TGGGGGCAGATGATTCCAGTA	0.433000													40	881					0	0	0.005524	0	0
EPHB3	2049	broad.mit.edu	37	3	184294876	184294876	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:184294876G>A	ENST00000330394.2	+	5	1711	c.1259G>A	c.(1258-1260)cGc>cAc	p.R420H	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	420	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GCCCACACGCGCTACACCTTT	0.627000													19	40					0	0	0.006122	0	0
DNAH11	8701	broad.mit.edu	37	7	21882167	21882167	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr7:21882167T>A	ENST00000328843.6	+	67	10749	c.10718T>A	c.(10717-10719)aTc>aAc	p.I3573N	DNAH11_ENST00000409508.3_Missense_Mutation_p.I3566N			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3573	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TTTAGGTATATCAGGATTGGA	0.388000									Kartagener syndrome				8	39					0	0	0.003080	0	0
TMEM41B	440026	broad.mit.edu	37	11	9321190	9321190	+	Silent	SNP	A	A	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:9321190A>G	ENST00000528080.1	-	2	518	c.180T>C	c.(178-180)atT>atC	p.I60I	TMEM41B_ENST00000527813.1_Silent_p.I60I|TMEM41B_ENST00000533723.1_Silent_p.I60I	NM_015012.3	NP_055827.1	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B	60						integral to membrane				kidney(1)|large_intestine(2)|lung(1)|prostate(1)|urinary_tract(2)	7				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)		CAGATAAGAAAATGGACACCA	0.299000													11	42					0	0	0.008291	0	0
ADORA1	134	broad.mit.edu	37	1	203097989	203097989	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:203097989C>T	ENST00000367236.4	+	2	941	c.20C>T	c.(19-21)gCt>gTt	p.A7V	ADORA1_ENST00000309502.3_Missense_Mutation_p.A7V|ADORA1_ENST00000337894.4_Missense_Mutation_p.A7V|ADORA1_ENST00000367235.1_Missense_Mutation_p.A7V	NM_001048230.1	NP_001041695.1	P30542	AA1R_HUMAN	adenosine A1 receptor	7					induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(9)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	TCCATCTCAGCTTTCCAGGCC	0.657000													18	81					0	0	0.008871	0	0
SPESP1	246777	broad.mit.edu	37	15	69238803	69238803	+	Silent	SNP	C	C	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr15:69238803C>G	ENST00000310673.3	+	2	1084	c.930C>G	c.(928-930)ctC>ctG	p.L310L	NOX5_ENST00000448182.3_Intron|NOX5_ENST00000260364.5_Intron|RP11-809H16.2_ENST00000557966.1_RNA|NOX5_ENST00000455873.3_Intron	NM_145658.3	NP_663633.1	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1	310					multicellular organismal development	acrosomal vesicle				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	19						GATCTAAACTCTATGAATATT	0.318000													15	42					0	0	0.004007	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70585257	70585257	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:70585257G>A	ENST00000260126.3	-	10	3100	c.2394C>T	c.(2392-2394)ttC>ttT	p.F798F	SLCO5A1_ENST00000530307.1_Silent_p.F743F|SLCO5A1_ENST00000524945.1_3'UTR	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	798						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CCTGGGTGCTGAAAGCTGGGC	0.577000													26	120					0	0	0.006320	0	0
CLVS2	134829	broad.mit.edu	37	6	123319045	123319045	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:123319045G>C	ENST00000275162.4	+	2	1458	c.123G>C	c.(121-123)agG>agC	p.R41S	CLVS2_ENST00000368438.1_Intron	NM_001010852.2	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2	41					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						TCATCACCAGGCCGGACATTG	0.567000													19	53					0	0	0.007413	0	0
OR5H6	79295	broad.mit.edu	37	3	97983471	97983471	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:97983471G>C	ENST00000383696.2	+	1	384	c.343G>C	c.(343-345)Gta>Cta	p.V115L	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TGAATGCATGGTACAATTTTT	0.388000													23	113					0	0	0.002780	0	0
SYNE2	23224	broad.mit.edu	37	14	64518705	64518705	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr14:64518705A>G	ENST00000358025.3	+	48	8304	c.8074A>G	c.(8074-8076)Agg>Ggg	p.R2692G	SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Missense_Mutation_p.R2692G|SYNE2_ENST00000554584.1_Missense_Mutation_p.R2725G	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2692					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCAGATGAAGAGGATTTGGGG	0.418000													15	87					0	0	0.002450	0	0
KCNK5	8645	broad.mit.edu	37	6	39158824	39158824	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:39158824T>C	ENST00000359534.3	-	5	1680	c.1342A>G	c.(1342-1344)Agc>Ggc	p.S448G		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	448					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						TGCTGGGGGCTCTCCTCCCCT	0.627000													4	12					0	0	0.000248	0	0
SEMA3A	10371	broad.mit.edu	37	7	83764187	83764187	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr7:83764187C>T	ENST00000265362.3	-	2	507	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	SEMA3A_ENST00000436949.1_Missense_Mutation_p.E65K	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	65	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CTACTCCGTTCCTCATCCAAA	0.383000													17	40					0	0	0.004990	0	0
ROCK1	6093	broad.mit.edu	37	18	18622625	18622625	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr18:18622625T>C	ENST00000399799.1	-	7	1661	c.721A>G	c.(721-723)Att>Gtt	p.I241V		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	241	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					TCAGGGGAAATATAATCAGGT	0.393000													10	32					0	0	0.001855	0	0
DNM3	26052	broad.mit.edu	37	1	172011156	172011156	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:172011156C>T	ENST00000358155.4	+	8	1176	c.1000C>T	c.(1000-1002)Cag>Tag	p.Q334*	DNM3_ENST00000520906.1_Nonsense_Mutation_p.Q334*|DNM3_ENST00000367731.1_Nonsense_Mutation_p.Q334*|DNM3_ENST00000367733.2_Nonsense_Mutation_p.Q334*|DNM3_ENST00000355305.5_Nonsense_Mutation_p.Q334*	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	334					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						CAGGATGGTTCAGCAATTTGC	0.368000													23	87					0	0	0.005443	0	0
ASAH1	427	broad.mit.edu	37	8	17918918	17918918	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:17918918G>C	ENST00000262097.6	-	10	1064	c.753C>G	c.(751-753)ttC>ttG	p.F251L	ASAH1_ENST00000520781.1_Missense_Mutation_p.F226L|ASAH1_ENST00000314146.10_Missense_Mutation_p.F245L|ASAH1_ENST00000381733.4_Missense_Mutation_p.F267L|ASAH1_ENST00000417108.2_Missense_Mutation_p.F161L	NM_177924.3	NP_808592.2	Q13510	ASAH1_HUMAN	N-acylsphingosine amidohydrolase (acid ceramidase) 1	251					ceramide metabolic process	lysosome	ceramidase activity			breast(1)|endometrium(2)|large_intestine(4)|lung(2)	9				Colorectal(111;0.0646)|COAD - Colon adenocarcinoma(73;0.228)		TTCTAGTGAGGAACCCTATCC	0.328000													12	48					0	0	0.004007	0	0
SLC25A43	203427	broad.mit.edu	37	X	118586008	118586008	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:118586008G>C	ENST00000217909.7	+	4	1071	c.727G>C	c.(727-729)Gat>Cat	p.D243H	SLC25A43_ENST00000336249.7_Missense_Mutation_p.R185T|SLC25A43_ENST00000488158.1_3'UTR	NM_145305.2	NP_660348.2	Q8WUT9	S2543_HUMAN	solute carrier family 25, member 43	243					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	9						TGGAGGAGTAGATGTCCATTT	0.512000													32	112					0	0	0.001786	0	0
C6orf118	168090	broad.mit.edu	37	6	165706919	165706919	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:165706919G>A	ENST00000543069.1	-	6	1372	c.791C>T	c.(790-792)tCt>tTt	p.S264F	C6orf118_ENST00000230301.8_Missense_Mutation_p.S368F			Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	368										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		TTCCTTTGCAGACTGCAGCAA	0.453000													39	109					0	0	0.007835	0	0
GRIP1	23426	broad.mit.edu	37	12	66742846	66742846	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:66742846T>C	ENST00000359742.4	-	25	3580	c.3340A>G	c.(3340-3342)Agc>Ggc	p.S1114G	GRIP1_ENST00000398016.3_Missense_Mutation_p.S1062G|GRIP1_ENST00000286445.7_Missense_Mutation_p.S1099G			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	1114					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CCACCGTGGCTAGGCTGCTGG	0.413000													4	259					0	0	0.000248	0	0
NUP155	9631	broad.mit.edu	37	5	37303483	37303483	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:37303483G>A	ENST00000231498.3	-	28	3399	c.3196C>T	c.(3196-3198)Cga>Tga	p.R1066*	NUP155_ENST00000381843.2_Nonsense_Mutation_p.R1007*|NUP155_ENST00000513532.1_Nonsense_Mutation_p.R1002*|NUP155_ENST00000502533.1_5'UTR	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	1066					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTGGCCATTCGGACTAGATGT	0.378000													13	37					0	0	0.001368	0	0
TMEM132E	124842	broad.mit.edu	37	17	32953441	32953441	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:32953441G>A	ENST00000321639.5	+	2	691	c.363G>A	c.(361-363)acG>acA	p.T121T		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	121						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		AGCGCCTGACGGTGAACTGGA	0.697000													6	25					0	0	0.001984	0	0
TP53BP2	7159	broad.mit.edu	37	1	223984132	223984132	+	Silent	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:223984132G>C	ENST00000391878.2	-	14	2490	c.1722C>G	c.(1720-1722)ctC>ctG	p.L574L	TP53BP2_ENST00000343537.7_Silent_p.L703L|TP53BP2_ENST00000498843.1_5'UTR|TP53BP2_ENST00000391879.2_5'UTR	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	697					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		TAGTTGGGCTGAGTGGCCGAG	0.468000													45	122					0	0	0.003214	0	0
ABCA4	24	broad.mit.edu	37	1	94526180	94526180	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:94526180G>A	ENST00000370225.3	-	14	2159	c.2073C>T	c.(2071-2073)gtC>gtT	p.V691V	ABCA4_ENST00000535735.1_Silent_p.V691V	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	691					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CTGCATTGGAGACACCCTGAT	0.483000													20	54					0	0	0.001882	0	0
OGT	8473	broad.mit.edu	37	X	70787355	70787355	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:70787355G>A	ENST00000373719.3	+	20	2812	c.2595G>A	c.(2593-2595)ctG>ctA	p.L865L	OGT_ENST00000373701.3_Silent_p.L855L	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	865					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					TTTAGATTCTGAAGCGTGTTC	0.398000													18	40					0	0	0.007413	0	0
GRIN2B	2904	broad.mit.edu	37	12	13715886	13715886	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:13715886G>A	ENST00000279593.3	-	13	4495	c.4286C>T	c.(4285-4287)cCg>cTg	p.P1429L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1429					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGAGACCACCGGCTTGTTGGT	0.607000													16	54					0	0	0.003163	0	0
LYSMD3	116068	broad.mit.edu	37	5	89814695	89814695	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:89814695C>G	ENST00000315948.6	-	3	1006	c.862G>C	c.(862-864)Gat>Cat	p.D288H	LYSMD3_ENST00000500869.2_Missense_Mutation_p.K129N|LYSMD3_ENST00000509384.1_3'UTR	NM_198273.1	NP_938014.1	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain containing 3	288					cell wall macromolecule catabolic process	integral to membrane				breast(2)|large_intestine(1)|lung(2)|prostate(1)|urinary_tract(1)	7		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)		TTATGATCATCTTGTTGGCTG	0.388000													3	113					0	0	0.000248	0	0
COL6A1	1291	broad.mit.edu	37	21	47404294	47404294	+	Silent	SNP	C	C	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr21:47404294C>G	ENST00000361866.3	+	3	453	c.339C>G	c.(337-339)ctC>ctG	p.L113L		NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	113	N-terminal globular domain.|VWFA 1.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GCGACGCACTCAAAAGCAGCG	0.632000													7	20					0	0	0.001984	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35130052	35130052	+	RNA	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr7:35130052C>T	ENST00000436258.1	-	0	3317																											TATTTTTGTCCGAGCCCTTTA	0.264000													14	39					0	0	0.001855	0	0
TRHDE	29953	broad.mit.edu	37	12	72955951	72955951	+	Missense_Mutation	SNP	T	T	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:72955951T>G	ENST00000261180.4	+	8	1756	c.1660T>G	c.(1660-1662)Tta>Gta	p.L554V	TRHDE_ENST00000549138.1_3'UTR	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	554					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						GTAGGATTATTTAACCATTCA	0.274000													4	14					0	0	0.000248	0	0
AFF2	2334	broad.mit.edu	37	X	148037550	148037550	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:148037550G>C	ENST00000370460.2	+	11	2454	c.1975G>C	c.(1975-1977)Gaa>Caa	p.E659Q	AFF2_ENST00000370457.5_Missense_Mutation_p.E626Q|AFF2_ENST00000342251.3_Missense_Mutation_p.E626Q|AFF2_ENST00000286437.5_Missense_Mutation_p.E300Q	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	659					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CAAAGAAAAAGAAAGTGTGGA	0.483000													39	159					0	0	0.006230	0	0
ABCA13	154664	broad.mit.edu	37	7	48284272	48284272	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr7:48284272G>A	ENST00000435803.1	+	11	1386	c.1362G>A	c.(1360-1362)gcG>gcA	p.A454A		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	454					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TCAGAAATGCGATAGCTCAGA	0.418000													18	53					0	0	0.007413	0	0
PSMB9	5698	broad.mit.edu	37	6	32826344	32826344	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:32826344A>T	ENST00000453265.2	+	4	531	c.462A>T	c.(460-462)ttA>ttT	p.L154F	PSMB9_ENST00000395330.1_Intron|PSMB9_ENST00000374859.2_Intron			P28065	PSB9_HUMAN	proteasome (prosome, macropain) subunit, beta type, 9	0					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			large_intestine(4)|lung(4)|skin(1)	9						GAAGTAGATTATGAGGAACAG	0.507000													6	16					0	0	0.001168	0	0
RUNX1T1	862	broad.mit.edu	37	8	93026818	93026818	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:93026818G>A	ENST00000523629.1	-	4	911	c.457C>T	c.(457-459)Ctg>Ttg	p.L153L	RUNX1T1_ENST00000521553.1_Silent_p.L116L|RUNX1T1_ENST00000265814.3_Silent_p.L153L|RUNX1T1_ENST00000520724.1_Silent_p.L116L|RUNX1T1_ENST00000518844.1_Silent_p.L126L|RUNX1T1_ENST00000436581.2_Silent_p.L164L|RUNX1T1_ENST00000396218.1_Silent_p.L126L|RUNX1T1_ENST00000422361.2_Silent_p.L116L|RUNX1T1_ENST00000360348.2_Silent_p.L116L	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	153	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			ACTAGTCCCAGAACGAGGGTG	0.493000													41	74					0	0	0.008740	0	0
ZNF530	348327	broad.mit.edu	37	19	58117555	58117555	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:58117555G>C	ENST00000332854.6	+	3	882	c.662G>C	c.(661-663)aGa>aCa	p.R221T	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAATCTTTTAGAGAGAAATCT	0.438000													3	69					0	0	0.004672	0	0
PEG3	5178	broad.mit.edu	37	19	57326231	57326231	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:57326231C>A	ENST00000326441.9	-	10	3942	c.3579G>T	c.(3577-3579)atG>atT	p.M1193I	PEG3_ENST00000593695.1_Missense_Mutation_p.M1067I|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.M1069I|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000221722.5_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.M1193I|ZIM2_ENST00000593711.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1193					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CACACCCCTTCATGGAATACA	0.473000													21	93					1.50039e-11	2.67102e-11	0.001882	1	0
POLR3A	11128	broad.mit.edu	37	10	79737376	79737376	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:79737376C>A	ENST00000372371.3	-	31	4170	c.4033G>T	c.(4033-4035)Gag>Tag	p.E1345*		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	1345					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			ATGATGCACTCAGACACCCCT	0.478000													17	59					0.00074312	0.00124109	0.006122	1	0
CDK3	1018	broad.mit.edu	37	17	74001438	74001438	+	Silent	SNP	G	G	A	rs150329289		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:74001438G>A	ENST00000425876.2	+	7	940	c.852G>A	c.(850-852)ccG>ccA	p.P284P	CDK3_ENST00000448471.1_Silent_p.P284P|TEN1-CDK3_ENST00000567351.1_RNA			Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	284	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						TGGCCCACCCGTACTTCTCAT	0.582000													12	53					0	0	0.000978	0	0
MAGEA11	4110	broad.mit.edu	37	X	148797305	148797305	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:148797305G>T	ENST00000355220.5	+	4	336	c.234G>T	c.(232-234)agG>agT	p.R78S	MAGEA11_ENST00000333104.4_Missense_Mutation_p.R49S	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	78						cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GGAGTCCCAGGAGAACCCAGA	0.502000													31	124					1.99505e-19	3.63144e-19	0.002445	1	0
PCDHGB2	56103	broad.mit.edu	37	5	140741612	140741612	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:140741612C>T	ENST00000522605.1	+	1	1910	c.1910C>T	c.(1909-1911)gCg>gTg	p.A637V	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACAGGGACGCGGCCCGCCAG	0.692000													8	17					0	0	0.001368	0	0
LMTK3	114783	broad.mit.edu	37	19	49013282	49013282	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:49013282G>A	ENST00000600059.1	-	3	586	c.359C>T	c.(358-360)tCa>tTa	p.S120L	LMTK3_ENST00000270238.3_Missense_Mutation_p.S149L					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GGCAGTACCTGAGTGTGAAGG	0.622000													10	33					0	0	0.001855	0	0
CCDC125	202243	broad.mit.edu	37	5	68581236	68581236	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:68581236A>G	ENST00000383374.2	-	9	956	c.872T>C	c.(871-873)cTt>cCt	p.L291P	CCDC125_ENST00000511257.1_Silent_p.P261P|CCDC125_ENST00000396499.1_Silent_p.P386P|CCDC125_ENST00000460090.1_5'UTR|CCDC125_ENST00000396496.2_Silent_p.P386P			Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	0						cytoplasm				breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|urinary_tract(1)	19		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		TGTTTTCTGAAGGGAGCATAC	0.418000													17	57					0	0	0.001523	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854235	12854235	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:12854235C>T	ENST00000332296.7	+	3	562	c.459C>T	c.(457-459)atC>atT	p.I153I		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	153										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCATAGACATCTGCCTCAAGG	0.522000													71	273					0	0	0.003610	0	0
LIPE-AS1	100996307	broad.mit.edu	37	19	42989362	42989362	+	RNA	SNP	C	C	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:42989362C>A	ENST00000594688.1	+	0	1450				LIPE-AS1_ENST00000593740.2_RNA|LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000596116.1_RNA|LIPE-AS1_ENST00000457234.2_RNA|LIPE-AS1_ENST00000594624.2_RNA	NR_073179.1																						ATTTCCACATCGGCAGTCAAA	0.393000													9	31					7.48243e-07	1.2827e-06	0.006214	1	0
CSMD3	114788	broad.mit.edu	37	8	113564847	113564847	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:113564847T>A	ENST00000297405.5	-	26	4581	c.4337A>T	c.(4336-4338)gAg>gTg	p.E1446V	CSMD3_ENST00000455883.2_Missense_Mutation_p.E1342V|CSMD3_ENST00000352409.3_Missense_Mutation_p.E1446V|CSMD3_ENST00000343508.3_Missense_Mutation_p.E1406V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1446	CUB 8.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGGATCTACCTCAATCATCCA	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	34					0	0	0.003163	0	0
MDN1	23195	broad.mit.edu	37	6	90392899	90392899	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:90392899C>T	ENST00000369393.3	-	73	12169	c.12054G>A	c.(12052-12054)ctG>ctA	p.L4018L	MDN1_ENST00000428876.1_Silent_p.L4018L			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	4018					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTGCCCTGTTCAGATTCTGAA	0.547000													18	47					0	0	0.007413	0	0
ARSI	340075	broad.mit.edu	37	5	149677008	149677008	+	Silent	SNP	G	G	A	rs141146390		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:149677008G>A	ENST00000328668.7	-	2	2058	c.1479C>T	c.(1477-1479)gcC>gcT	p.A493A		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	493						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTTATATTCGGCCAGGCGAG	0.632000													25	95					0	0	0.004656	0	0
TNRC6A	27327	broad.mit.edu	37	16	24801451	24801451	+	Silent	SNP	A	A	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr16:24801451A>T	ENST00000395799.3	+	6	1617	c.1488A>T	c.(1486-1488)ccA>ccT	p.P496P	TNRC6A_ENST00000315183.7_Silent_p.P496P	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	496	Sufficient for interaction with EIF2C1, EIF2C3 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TGCAGGCTCCATCAGGTATGA	0.473000													13	91					0	0	0.002450	0	0
MALSU1	115416	broad.mit.edu	37	7	23339007	23339007	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr7:23339007C>T	ENST00000466681.1	+	1	189	c.36C>T	c.(34-36)gcC>gcT	p.A12A	MALSU1_ENST00000479974.1_Intron	NM_138446.1	NP_612455.1	Q96EH3	CG030_HUMAN	mitochondrial assembly of ribosomal large subunit 1	12						mitochondrion											GGCTGCTCGCCCCACTAATGT	0.716000													4	15					0	0	0.000248	0	0
RFX6	222546	broad.mit.edu	37	6	117246698	117246698	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:117246698C>T	ENST00000332958.2	+	16	1777	c.1761C>T	c.(1759-1761)gaC>gaT	p.D587D		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	587					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						TTTCCAGCGACGCTGTGAAGA	0.517000													30	95					0	0	0.001786	0	0
OR2J2	26707	broad.mit.edu	37	6	29142034	29142034	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:29142034G>T	ENST00000377167.2	+	1	724	c.622G>T	c.(622-624)Gtt>Ttt	p.V208F		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	208					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						CTCCATTTTTGTTCTCATACC	0.468000													43	109					2.26627e-22	4.14843e-22	0.007835	1	0
CXorf22	170063	broad.mit.edu	37	X	35989886	35989886	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:35989886A>C	ENST00000297866.5	+	12	2220	c.2154A>C	c.(2152-2154)agA>agC	p.R718S		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	718										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						CTGTGAGAAGAAAGGCACGTG	0.363000													16	20					0	0	0.004007	0	0
ABLIM1	3983	broad.mit.edu	37	10	116251550	116251550	+	Splice_Site	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:116251550C>T	ENST00000369252.4	-	7	1103	c.802_splice	c.e7+1	p.G268_splice	ABLIM1_ENST00000369266.3_Splice_Site_p.G12_splice|ABLIM1_ENST00000369253.2_Splice_Site_p.G12_splice|ABLIM1_ENST00000277895.5_Splice_Site_p.G328_splice|ABLIM1_ENST00000392952.3_Splice_Site_p.G12_splice|ABLIM1_ENST00000533213.2_Splice_Site_p.G268_splice	NM_001003407.1|NM_001003408.1	NP_001003407.1|NP_001003408.1	O14639	ABLM1_HUMAN	actin binding LIM protein 1	328	LIM zinc-binding 3.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		TCCACCTCACCTTGAAGATAC	0.438000													25	94					0	0	0.002780	0	0
GPR133	283383	broad.mit.edu	37	12	131476850	131476850	+	Silent	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:131476850C>T	ENST00000261654.5	+	8	1438	c.879C>T	c.(877-879)ccC>ccT	p.P293P	RP11-76C10.5_ENST00000542980.1_lincRNA|GPR133_ENST00000535015.1_Silent_p.P325P	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	293					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TCCAAAGTCCCGGAGTGATAC	0.458000													45	129					0	0	0.002522	0	0
OBP2A	29991	broad.mit.edu	37	9	138439759	138439759	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:138439759C>T	ENST00000539850.1	+	4	346	c.320C>T	c.(319-321)aCg>aTg	p.T107M	OBP2A_ENST00000340780.3_Missense_Mutation_p.T107M|OBP2A_ENST00000371776.1_Missense_Mutation_p.T107M|OBP2A_ENST00000342114.4_Silent_p.D62D			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	107					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		CTGCCCGGGACGGACGACTAC	0.607000													10	26					0	0	0.008291	0	0
CRYBB3	1417	broad.mit.edu	37	22	25601219	25601219	+	Silent	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr22:25601219G>A	ENST00000215855.2	+	5	440	c.360G>A	c.(358-360)gaG>gaA	p.E120E	CRYBB3_ENST00000404334.1_Intron	NM_004076.3	NP_004067.1	P26998	CRBB3_HUMAN	crystallin, beta B3	120	Beta/gamma crystallin 'Greek key' 3.				visual perception		protein binding|structural constituent of eye lens			large_intestine(2)|lung(2)|prostate(1)	5						ATCTGTTTGAGAACCCAGCTT	0.567000													14	49					0	0	0.003163	0	0
GTPBP8	29083	broad.mit.edu	37	3	112718380	112718380	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:112718380C>G	ENST00000383677.3	+	4	670	c.655C>G	c.(655-657)Caa>Gaa	p.Q219E	GTPBP8_ENST00000467752.1_Missense_Mutation_p.Q141E|GTPBP8_ENST00000383678.2_Missense_Mutation_p.Q252E|GTPBP8_ENST00000473129.1_Missense_Mutation_p.Q102E	NM_138485.1	NP_612494.1	Q8N3Z3	GTPB8_HUMAN	GTP-binding protein 8 (putative)	252	G.				barrier septum formation		GTP binding			kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	6						CATGAAAACTCAAGGATGTTT	0.289000													14	65					0	0	0.002450	0	0
TBL1XR1	79718	broad.mit.edu	37	3	176765338	176765338	+	Splice_Site	SNP	C	C	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:176765338C>G	ENST00000430069.1	-	8	962		c.e8-1		TBL1XR1-AS1_ENST00000454723.2_RNA|TBL1XR1_ENST00000457928.2_Splice_Site			Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1						canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			TACCTTCACTCTGCCAGAGAA	0.328000													8	29					0	0	0.004482	0	0
EFCAB12	90288	broad.mit.edu	37	3	129137260	129137260	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:129137260C>T	ENST00000505956.1	-	3	680	c.518G>A	c.(517-519)cGc>cAc	p.R173H	EFCAB12_ENST00000326085.3_Missense_Mutation_p.R173H	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12									p.R173H(1)									CACCATCTGGCGGGACAGCCG	0.612000													7	12					0	0	0.003080	0	0
FSTL1	11167	broad.mit.edu	37	3	120130792	120130792	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:120130792A>C	ENST00000295633.3	-	4	563	c.207T>G	c.(205-207)aaT>aaG	p.N69K	FSTL1_ENST00000424703.2_Missense_Mutation_p.N34K	NM_007085.4	NP_009016.1	Q12841	FSTL1_HUMAN	follistatin-like 1	69	Kazal-like.				BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(1)	20				GBM - Glioblastoma multiforme(114;0.189)		AGGTCTTGCCATTACTGCCAC	0.473000													25	81					0	0	0.002780	0	0
BAZ2B	29994	broad.mit.edu	37	2	160243034	160243034	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr2:160243034G>A	ENST00000392783.2	-	22	3796	c.3301C>T	c.(3301-3303)Cga>Tga	p.R1101*	BAZ2B_ENST00000392782.1_Nonsense_Mutation_p.R1065*|BAZ2B_ENST00000343439.5_Nonsense_Mutation_p.R1001*|AC008277.1_ENST00000420020.1_RNA|BAZ2B_ENST00000355831.2_Nonsense_Mutation_p.R1067*	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1101	DDT.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						CCAAAGTTTCGTAAGAACTGC	0.413000													13	45					0	0	0.001368	0	0
MED15	51586	broad.mit.edu	37	22	20940876	20940876	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr22:20940876C>T	ENST00000263205.7	+	18	2321	c.2252C>T	c.(2251-2253)tCg>tTg	p.S751L	MED15_ENST00000292733.7_Missense_Mutation_p.S711L|MED15_ENST00000425759.2_Missense_Mutation_p.S600L|MED15_ENST00000542773.1_3'UTR|MED15_ENST00000382974.2_Missense_Mutation_p.S640L|MED15_ENST00000541476.1_Missense_Mutation_p.S685L|MED15_ENST00000406969.1_Missense_Mutation_p.S685L	NM_001003891.1	NP_001003891.1	Q96RN5	MED15_HUMAN	mediator complex subunit 15	751					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			TTCCTCCAGTCGGTGCACCGC	0.677000													27	65					0	0	0.001786	0	0
PUS7L	83448	broad.mit.edu	37	12	44148421	44148421	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:44148421C>G	ENST00000416848.2	-	2	1116	c.628G>C	c.(628-630)Gta>Cta	p.V210L	PUS7L_ENST00000551923.1_Missense_Mutation_p.V210L|PUS7L_ENST00000344862.5_Missense_Mutation_p.V210L|PUS7L_ENST00000431332.3_Intron|PUS7L_ENST00000553166.1_Missense_Mutation_p.V210L	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	210					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TCTTCAGATACCAAATGACAA	0.299000													4	24					0	0	0.000248	0	0
MMP17	4326	broad.mit.edu	37	12	132323155	132323155	+	Splice_Site	SNP	A	A	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:132323155A>G	ENST00000360564.1	+	3	394		c.e3-1		MMP17_ENST00000535291.1_Splice_Site	NM_016155.4	NP_057239.4	Q9ULZ9	MMP17_HUMAN	matrix metallopeptidase 17 (membrane-inserted)						proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)	5	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		CTTTCCCTGCAGACGAGGCCA	0.667000													4	13					0	0	0.000602	0	0
TRPM3	80036	broad.mit.edu	37	9	73457992	73457992	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:73457992C>G	ENST00000377110.2	-	5	971	c.728G>C	c.(727-729)cGa>cCa	p.R243P	TRPM3_ENST00000396283.1_Missense_Mutation_p.R90P|TRPM3_ENST00000396285.1_Missense_Mutation_p.R90P|TRPM3_ENST00000360823.2_Missense_Mutation_p.R90P|TRPM3_ENST00000396292.4_Missense_Mutation_p.R90P|TRPM3_ENST00000357533.2_Missense_Mutation_p.R245P|TRPM3_ENST00000358082.3_Missense_Mutation_p.R90P|TRPM3_ENST00000361823.5_Missense_Mutation_p.R90P|TRPM3_ENST00000396280.5_Missense_Mutation_p.R90P|TRPM3_ENST00000377105.1_Missense_Mutation_p.R90P|TRPM3_ENST00000377106.1_Missense_Mutation_p.R90P|TRPM3_ENST00000423814.3_Missense_Mutation_p.R245P|TRPM3_ENST00000408909.2_Missense_Mutation_p.R90P|TRPM3_ENST00000377101.1_Missense_Mutation_p.R90P|TRPM3_ENST00000377097.3_Missense_Mutation_p.R90P|TRPM3_ENST00000377111.2_Missense_Mutation_p.R243P	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	243						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						TATCTTTCCTCGAGACTTAGA	0.423000													7	38					0	0	0.004482	0	0
KIF5B	3799	broad.mit.edu	37	10	32329357	32329357	+	Missense_Mutation	SNP	T	T	C	rs147256984		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:32329357T>C	ENST00000302418.4	-	3	700	c.243A>G	c.(241-243)atA>atG	p.I81M		NM_004521.2	NP_004512.1	P33176	KINH_HUMAN	kinesin family member 5B	81	Kinesin-motor.				stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(8)|KIF5B/RET(79)	NS(2)|breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)	35		Prostate(175;0.0137)				CATATGCAAATATTGTTCCAT	0.328000			T	"""RET, ALK"""	NSCLC								13	43					0	0	0.003163	0	0
IL1R2	7850	broad.mit.edu	37	2	102638648	102638649	+	Splice_Site	INS	-	-	A			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr2:102638648_102638649insA	ENST00000332549.3	+	6	917_918		c.e6-1		IL1R2_ENST00000441002.1_Splice_Site|IL1R2_ENST00000393414.2_Splice_Site	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II						immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	ATCTTTCTCAGAAAAAAAAGAA	0.441													7	217	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187540720	187540742	+	Frame_Shift_Del	DEL	GCCAGTGCTGCTGTCTACATGAA	GCCAGTGCTGCTGTCTACATGAA	-			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr4:187540720_187540742delGCCAGTGCTGCTGTCTACATGAA	ENST00000441802.2	-	10	7207_7229	c.6998_7020delTTCATGTAGACAGCAGCACTGGC	c.(6997-7020)tfs	p.FHVDSSTG2333fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2333	Cadherin 21.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GTGAGATGAGGCCAGTGCTGCTGTCTACATGAAAATGATCATG	0.480										HNSCC(5;0.00058)			8	154	---	---	---	---					
AKAP7	9465	broad.mit.edu	37	6	131540807	131540807	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:131540807delA	ENST00000431975.2	+	7	807	c.709delA	c.(709-711)aafs	p.K238fs	AKAP7_ENST00000263050.3_5'UTR|AKAP7_ENST00000368123.4_Frame_Shift_Del_p.K216fs|AKAP7_ENST00000541650.1_Frame_Shift_Del_p.K237fs|AKAP7_ENST00000537868.1_5'UTR	NM_016377.3	NP_057461.2	O43687	AKA7A_HUMAN	A kinase (PRKA) anchor protein 7	0					intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|stomach(1)	13	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)		CAAGGGAGTGAAAAAAATAGA	0.308													7	34	---	---	---	---					
FOLH1B	219595	broad.mit.edu	37	11	89407165	89407165	+	RNA	DEL	T	T	-	rs112016970		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:89407165delT	ENST00000532352.1	+	0	1114							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						CATCAATGACTTTTTTTTTTT	0.303													5	5	---	---	---	---					
COPZ1	22818	broad.mit.edu	37	12	54718955	54718956	+	In_Frame_Ins	INS	-	-	GCG			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:54718955_54718956insGCG	ENST00000262061.2	+	1	45_46	c.8_9insGCG	c.(7-9)gct>gGCGct	p.2_3insG	COPZ1_ENST00000455864.2_In_Frame_Ins_p.2_3insG|COPZ1_ENST00000549116.1_In_Frame_Ins_p.2_3insG|COPZ1_ENST00000549043.1_5'UTR|COPZ1_ENST00000551779.1_In_Frame_Ins_p.2_3insG|RP11-968A15.8_ENST00000553061.1_RNA|COPZ1_ENST00000552218.1_In_Frame_Ins_p.2_3insG|COPZ1_ENST00000552362.1_In_Frame_Ins_p.2_3insG|COPZ1_ENST00000416254.2_5'UTR|COPZ1_ENST00000553231.1_In_Frame_Ins_p.2_3insG	NM_001271734.1|NM_001271736.1|NM_016057.1	NP_001258663.1|NP_001258665.1|NP_057141.1	P61923	COPZ1_HUMAN	coatomer protein complex, subunit zeta 1	2					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol				kidney(1)|lung(4)	5						AAGATGGAGGCGCTGATTTTGG	0.619											OREG0021891	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	4	---	---	---	---					
TPTE2P1	646405	broad.mit.edu	37	13	25527490	25527491	+	RNA	INS	-	-	AAAAAG			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr13:25527490_25527491insAAAAAG	ENST00000429698.1	-	0	282																											AGGAAGGTTCTAAAAAAAATTT	0.252													3	4	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578267	7578267	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:7578267delA	ENST00000420246.2	-	6	714	c.582delT	c.(580-582)ctfs	p.L194fs	TP53_ENST00000413465.2_Frame_Shift_Del_p.L194fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.L194fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.L194fs|TP53_ENST00000574684.1_Intron|TP53_ENST00000269305.4_Frame_Shift_Del_p.L194fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.L194fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	194	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		L -> F (in sporadic cancers; somatic mutation).|L -> H (in sporadic cancers; somatic mutation).|L -> I (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.?(6)|p.L194L(4)|p.A189_V197delAPPQHLIRV(4)|p.I195fs*52(3)|p.P191_E198>Q(3)|p.I63fs*>28(1)|p.I195fs*14(1)|p.L194fs*52(1)|p.I195fs*50(1)|p.L194fs*14(1)|p.P191fs*6(1)|p.I102fs*52(1)|p.P98_E105>Q(1)|p.H193_I195delHLI(1)|p.P59_E66>Q(1)|p.H193_I195>AP(1)|p.I195fs*12(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCACTCGGATAAGATGCTGAG	0.552		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	33	---	---	---	---					
