Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLEC	5339	broad.mit.edu	37	8	144998170	144998170	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr8:144998170G>A	ENST00000322810.4	-	31	6507	c.6338C>T	c.(6337-6339)gCg>gTg	p.A2113V	PLEC_ENST00000527096.1_Missense_Mutation_p.A1999V|PLEC_ENST00000354958.2_Missense_Mutation_p.A1954V|PLEC_ENST00000354589.3_Missense_Mutation_p.A1976V|PLEC_ENST00000436759.2_Missense_Mutation_p.A2003V|PLEC_ENST00000356346.3_Missense_Mutation_p.A1962V|PLEC_ENST00000398774.2_Missense_Mutation_p.A1944V|PLEC_ENST00000357649.2_Missense_Mutation_p.A1980V|PLEC_ENST00000345136.3_Missense_Mutation_p.A1976V	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2113	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CTCCTCCGCCGCCAGCTGCCG	0.741000													8	7					0	0	0.013537	0	0
POLQ	10721	broad.mit.edu	37	3	121208235	121208235	+	Silent	SNP	A	A	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:121208235A>G	ENST00000264233.5	-	16	3671	c.3543T>C	c.(3541-3543)aaT>aaC	p.N1181N		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	1181					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TCATATAAACATTCTGGTTTT	0.378000								DNA polymerases (catalytic subunits)					7	204					0	0	0.038147	0	0
SLF2	55719	broad.mit.edu	37	10	102689617	102689617	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:102689617T>G	ENST00000238961.3	+	8	2344	c.2196T>G	c.(2194-2196)atT>atG	p.I732M	FAM178A_ENST00000370269.3_Missense_Mutation_p.I732M	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A	732																	CAGTTACAATTGATGCTATTC	0.294000													12	56					0	0	0.016723	0	0
CHST11	50515	broad.mit.edu	37	12	105151235	105151235	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:105151235A>G	ENST00000303694.5	+	3	1152	c.713A>G	c.(712-714)gAg>gGg	p.E238G	CHST11_ENST00000549260.1_Missense_Mutation_p.E233G	NM_018413.5	NP_060883.1	Q9NPF2	CHSTB_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 11	238					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)	18						GTCAAATTCGAGGAGTTTGTG	0.567000													20	57					0	0	0.014323	0	0
GNG8	94235	broad.mit.edu	37	19	47137457	47137457	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr19:47137457G>T	ENST00000300873.4	-	2	91	c.89C>A	c.(88-90)tCg>tAg	p.S30*		NM_033258.1	NP_150283.1	Q9UK08	GBG8_HUMAN	guanine nucleotide binding protein (G protein), gamma 8	30					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	extracellular region|heterotrimeric G-protein complex	GTPase activity|signal transducer activity						Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.000621)|Epithelial(262;0.0171)|GBM - Glioblastoma multiforme(486;0.0325)		TGCTGCCTGCGACACCTGCGA	0.677000													6	11					0.00198382	0.00207265	0.029380	1	0
CYFIP1	23191	broad.mit.edu	37	15	22956374	22956374	+	Silent	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:22956374G>A	ENST00000435939.2	+	1	620	c.318G>A	c.(316-318)gaG>gaA	p.E106E	CYFIP1_ENST00000313077.7_Intron|CYFIP1_ENST00000560848.1_Intron	NM_001033028.1	NP_001028200.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	0					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GGCTTTTTGAGTTTGGCATAA	0.547000													8	29					0	0	0.004482	0	0
KALRN	8997	broad.mit.edu	37	3	124103747	124103747	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:124103747C>T	ENST00000360013.3	+	11	1947	c.1820C>T	c.(1819-1821)aCg>aTg	p.T607M	KALRN_ENST00000460856.1_Missense_Mutation_p.T607M|KALRN_ENST00000240874.3_Missense_Mutation_p.T607M	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	607					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TTGGCTCAGACGGGGGAATGT	0.577000													7	53					0	0	0.038147	0	0
VPS18	57617	broad.mit.edu	37	15	41191580	41191580	+	Silent	SNP	C	C	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:41191580C>G	ENST00000220509.5	+	4	903	c.564C>G	c.(562-564)ctC>ctG	p.L188L	VPS18_ENST00000558474.1_Intron	NM_020857.2	NP_065908.1	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18 homolog (S. cerevisiae)	188					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			autonomic_ganglia(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	28		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CTCCGGATCTCTACTTCCGCC	0.602000													14	72					0	0	0.024245	0	0
TANC2	26115	broad.mit.edu	37	17	61391920	61391920	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr17:61391920G>A	ENST00000424789.2	+	8	1113	c.1109G>A	c.(1108-1110)gGa>gAa	p.G370E	AC037445.1_ENST00000581421.1_RNA|TANC2_ENST00000389520.4_Missense_Mutation_p.G370E	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	370							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						GTGATTGTGGGAAACATTGGA	0.498000													21	90					0	0	0.012319	0	0
PRODH	5625	broad.mit.edu	37	22	18906002	18906002	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr22:18906002A>C	ENST00000357068.6	-	11	1519	c.1254T>G	c.(1252-1254)gaT>gaG	p.D418E	PRODH_ENST00000420436.1_Missense_Mutation_p.D310E|PRODH_ENST00000334029.2_Missense_Mutation_p.D310E	NM_016335.4	NP_057419.4	O43272	PROD_HUMAN	proline dehydrogenase (oxidase) 1	418					glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)|endometrium(3)|lung(4)|upper_aerodigestive_tract(1)	9					L-Proline(DB00172)	TGTCATAGGCATCCTGTGGGG	0.662000													3	21					0	0	0.014758	0	0
DTX1	1840	broad.mit.edu	37	12	113515335	113515335	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:113515335T>G	ENST00000257600.3	+	2	869	c.366T>G	c.(364-366)gaT>gaG	p.D122E		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	122	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						CGGCCTACGATATGGACATCT	0.622000													4	46					0	0	0.009096	0	0
TRIM46	80128	broad.mit.edu	37	1	155152367	155152367	+	Silent	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:155152367C>T	ENST00000368382.1	+	8	1613	c.1476C>T	c.(1474-1476)ggC>ggT	p.G492G	TRIM46_ENST00000368385.4_Silent_p.G515G|TRIM46_ENST00000468878.1_3'UTR|TRIM46_ENST00000545012.1_Silent_p.G389G|TRIM46_ENST00000543729.1_3'UTR|TRIM46_ENST00000368383.3_Silent_p.G515G|TRIM46_ENST00000334634.4_Silent_p.G515G|TRIM46_ENST00000392451.2_3'UTR	NM_001256599.1|NM_001256600.1|NM_001256601.1|NM_025058.4	NP_001243528.1|NP_001243529.1|NP_001243530.1|NP_079334.3	Q7Z4K8	TRI46_HUMAN	tripartite motif containing 46	515	Fibronectin type-III.					intracellular	zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	29	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCGGCTACGGCGAATACAGTG	0.657000													8	25					0	0	0.004482	0	0
DYDC2	84332	broad.mit.edu	37	10	82126495	82126495	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:82126495G>A	ENST00000372199.1	+	6	920	c.322G>A	c.(322-324)Gac>Aac	p.D108N	DYDC2_ENST00000372198.1_Missense_Mutation_p.D122N|DYDC2_ENST00000372197.1_Missense_Mutation_p.D108N|DYDC2_ENST00000256039.2_Missense_Mutation_p.D108N|DYDC2_ENST00000444807.2_Missense_Mutation_p.D108N			Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	108							protein binding			breast(1)|large_intestine(3)|lung(6)|skin(1)	11			Colorectal(32;0.229)			CATGCAGGAGGACACAAACCC	0.438000													4	147					0	0	0.021553	0	0
KIAA1549	57670	broad.mit.edu	37	7	138601971	138601971	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr7:138601971C>T	ENST00000440172.1	-	2	2449	c.2401G>A	c.(2401-2403)Gag>Aag	p.E801K	KIAA1549_ENST00000422774.1_Missense_Mutation_p.E801K|KIAA1549_ENST00000242365.4_Missense_Mutation_p.E751K	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	801						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						AAAGAAGACTCAGTTAAAATG	0.512000			O	BRAF	pilocytic astrocytoma								5	21					0	0	0.014758	0	0
NRBP2	340371	broad.mit.edu	37	8	144919254	144919254	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr8:144919254G>A	ENST00000442628.2	-	14	1359	c.1220C>T	c.(1219-1221)gCc>gTc	p.A407V	NRBP2_ENST00000327830.5_Missense_Mutation_p.A164V	NM_178564.3	NP_848659.2	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	407					negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)|kidney(1)|large_intestine(2)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CGGGGTCTTGGCCTTTTGGAC	0.607000													42	103					0	0	0.025465	0	0
MPPE1	65258	broad.mit.edu	37	18	11893497	11893497	+	Silent	SNP	G	G	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr18:11893497G>T	ENST00000588072.1	-	4	1581	c.360C>A	c.(358-360)atC>atA	p.I120I	MPPE1_ENST00000344987.7_Silent_p.I120I|MPPE1_ENST00000399978.2_Silent_p.I120I|MPPE1_ENST00000309976.9_Silent_p.I120I|MPPE1_ENST00000317235.7_Silent_p.I120I	NM_023075.5	NP_075563.3	Q53F39	MPPE1_HUMAN	metallophosphoesterase 1	120					ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	5						CTTCATCAAAGATATCCCCCA	0.537000													17	32					1.56452e-12	1.7112e-12	0.043863	1	0
GFRAL	389400	broad.mit.edu	37	6	55223938	55223938	+	Splice_Site	SNP	T	T	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr6:55223938T>C	ENST00000340465.2	+	6	1038		c.e6+2			NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like							integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CATGTTTCAGTAAGTTCCCCA	0.343000													8	41					0	0	0.038147	0	0
TPSD1	23430	broad.mit.edu	37	16	1306807	1306807	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr16:1306807G>C	ENST00000211076.3	+	3	412	c.264G>C	c.(262-264)aaG>aaC	p.K88N	TPSD1_ENST00000397534.2_Missense_Mutation_p.K81N	NM_012217.2	NP_036349.1	Q9BZJ3	TRYD_HUMAN	tryptase delta 1	88	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	20		Hepatocellular(780;0.00369)				GGGACATCAAGGATCTGGCCG	0.667000													3	25					0	0	0.004672	0	0
LRSAM1	90678	broad.mit.edu	37	9	130259572	130259572	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr9:130259572G>A	ENST00000323301.4	+	23	2475	c.1871G>A	c.(1870-1872)cGg>cAg	p.R624Q	LRSAM1_ENST00000300417.6_Missense_Mutation_p.R624Q|LRSAM1_ENST00000373322.1_Missense_Mutation_p.R624Q|LRSAM1_ENST00000373324.4_Missense_Mutation_p.R597Q|LRSAM1_ENST00000483302.1_3'UTR	NM_138361.5	NP_612370.3	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif containing 1	624	SAM.				negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(2)	16						GAGATCCTCCGGAGAGTCCAG	0.617000													7	26					0	0	0.004482	0	0
DST	667	broad.mit.edu	37	6	56472764	56472764	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr6:56472764A>T	ENST00000370754.5	-	39	6562	c.6563T>A	c.(6562-6564)cTg>cAg	p.L2188Q	DST_ENST00000370788.2_Intron|DST_ENST00000361203.3_Missense_Mutation_p.L2010Q|DST_ENST00000244364.6_Intron|DST_ENST00000312431.6_Missense_Mutation_p.L2010Q|DST_ENST00000421834.2_Intron|DST_ENST00000446842.2_Missense_Mutation_p.L1684Q|DST_ENST00000370769.4_Missense_Mutation_p.L2010Q			Q03001	DYST_HUMAN	dystonin	2010					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCCATCGTACAGCAAAAGCCT	0.393000													19	51					0	0	0.043863	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													5	70					0	0	0.006214	0	0
ARL14EP	120534	broad.mit.edu	37	11	30358279	30358279	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr11:30358279G>T	ENST00000282032.3	+	4	935	c.720G>T	c.(718-720)aaG>aaT	p.K240N		NM_152316.1	NP_689529.1			ADP-ribosylation factor-like 14 effector protein																		GTGACCGCAAGTGGCTGTATG	0.443000													16	100					1.02788e-11	1.10695e-11	0.033300	1	0
CDC42EP1	11135	broad.mit.edu	37	22	37962716	37962716	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr22:37962716C>G	ENST00000249014.4	+	2	780	c.360C>G	c.(358-360)atC>atG	p.I120M		NM_152243.2	NP_689449.1	Q00587	BORG5_HUMAN	CDC42 effector protein (Rho GTPase binding) 1	120					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(4)|prostate(5)	15	Melanoma(58;0.0574)					AGAACGCCATCTCCCTGCCCC	0.692000													16	82					0	0	0.028581	0	0
RASGRP3	25780	broad.mit.edu	37	2	33764264	33764264	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr2:33764264G>T	ENST00000403687.3	+	12	2005	c.1265G>T	c.(1264-1266)aGg>aTg	p.R422M	RASGRP3_ENST00000402538.3_Missense_Mutation_p.R422M|RASGRP3_ENST00000407811.1_Missense_Mutation_p.R421M	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	422	EF-hand 1.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					AAGCACATAAGGAAATTAGTG	0.517000													3	10					0.00909568	0.0093632	0.009096	1	0
JAK1	3716	broad.mit.edu	37	1	65332750	65332750	+	Silent	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:65332750C>T	ENST00000342505.4	-	7	1037	c.789G>A	c.(787-789)acG>acA	p.T263T		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	263	FERM.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TCAGGTCATGCGTGGACACGC	0.398000			Mis		ALL								4	144					0	0	0.014758	0	0
ARC	23237	broad.mit.edu	37	8	143695621	143695621	+	Silent	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr8:143695621G>A	ENST00000356613.2	-	1	1212	c.12C>T	c.(10-12)gaC>gaT	p.D4D		NM_015193.3	NP_056008.1	Q7LC44	ARC_HUMAN	activity-regulated cytoskeleton-associated protein	4					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	13	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				TGGTCCGGTGGTCCAGCTCCA	0.746000													4	10					0	0	0.014758	0	0
ISG20L2	81875	broad.mit.edu	37	1	156696882	156696882	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:156696882C>T	ENST00000313146.6	-	1	1345	c.563G>A	c.(562-564)gGc>gAc	p.G188D	ISG20L2_ENST00000368219.1_Missense_Mutation_p.G188D	NM_030980.1	NP_112242.1	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene 20kDa-like 2	188	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGTCCTGTGCCCACCATCTC	0.517000											OREG0013885	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	164					0	0	0.009096	0	0
NCK1	4690	broad.mit.edu	37	3	136664745	136664745	+	Missense_Mutation	SNP	G	G	A	rs149750260		TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:136664745G>A	ENST00000469404.1	+	2	446	c.355G>A	c.(355-357)Gtc>Atc	p.V119I	NCK1_ENST00000288986.2_Missense_Mutation_p.V183I|NCK1_ENST00000481752.1_Missense_Mutation_p.V183I	NM_001190796.1	NP_001177725.1	P16333	NCK1_HUMAN	NCK adaptor protein 1	183	SH3 2.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	13						AGCAGCAGTCGTCAATAACCT	0.428000													27	114					0	0	0.027356	0	0
NBPF3	84224	broad.mit.edu	37	1	21806606	21806606	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:21806606T>G	ENST00000318220.6	+	14	2151	c.1103T>G	c.(1102-1104)tTt>tGt	p.F368C	NBPF3_ENST00000342104.5_Missense_Mutation_p.F412C|NBPF3_ENST00000318249.5_Missense_Mutation_p.F424C|NBPF3_ENST00000454000.2_Missense_Mutation_p.F354C			Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	424	NBPF 2.					cytoplasm				breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	20		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CTGGATAGATTTTATTCAACT	0.468000													3	97					0	0	0.004672	0	0
CSF1	1435	broad.mit.edu	37	1	110466699	110466699	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:110466699G>A	ENST00000329608.6	+	6	1847	c.1456G>A	c.(1456-1458)Gag>Aag	p.E486K	CSF1_ENST00000420111.2_Missense_Mutation_p.E188K|CSF1_ENST00000369801.1_Missense_Mutation_p.E370K|CSF1_ENST00000369802.3_Missense_Mutation_p.E486K|CSF1_ENST00000344188.5_Missense_Mutation_p.E370K	NM_000757.5|NM_172211.3	NP_000748.3|NP_757350.1	P09603	CSF1_HUMAN	colony stimulating factor 1 (macrophage)	486					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			breast(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		GAGGCAGTCCGAGGGATCCTT	0.612000													20	61					0	0	0.018920	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42866219	42866219	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:42866219C>T	ENST00000455697.1	-	2	385	c.100G>A	c.(100-102)Gcc>Acc	p.A34T	PRICKLE1_ENST00000445766.2_Missense_Mutation_p.A34T|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.A34T|PRICKLE1_ENST00000552240.1_Missense_Mutation_p.A34T|PRICKLE1_ENST00000548696.1_Missense_Mutation_p.A34T	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	34	PET.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GGGACCCAGGCGTACTCCTCC	0.478000													11	43					0	0	0.010729	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													4	45					0	0	0.009096	0	0
CSMD1	64478	broad.mit.edu	37	8	3076900	3076900	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr8:3076900G>A	ENST00000520002.1	-	30	5107	c.4552C>T	c.(4552-4554)Ctc>Ttc	p.L1518F	CSMD1_ENST00000602723.1_Missense_Mutation_p.L1518F|CSMD1_ENST00000602557.1_Missense_Mutation_p.L1518F|CSMD1_ENST00000542608.1_Missense_Mutation_p.L1517F|CSMD1_ENST00000539096.1_Missense_Mutation_p.L1517F|CSMD1_ENST00000537824.1_Missense_Mutation_p.L1517F|CSMD1_ENST00000400186.3_Missense_Mutation_p.L1518F|CSMD1_ENST00000523387.1_5'UTR			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1518	CUB 9.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCCCAATGAGGGGGCTGTTG	0.478000													3	3					0	0	0.004672	0	0
PRG2	5553	broad.mit.edu	37	11	57154973	57154973	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr11:57154973C>A	ENST00000311862.5	-	6	717	c.644G>T	c.(643-645)aGa>aTa	p.R215I	PRG2_ENST00000533605.1_Missense_Mutation_p.R204I|PRG2_ENST00000525955.1_Missense_Mutation_p.R215I	NM_001243245.1|NM_002728.4	NP_001230174.1|NP_002719.3			proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)											central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAAGGAAGTCTTCTGAGGCA	0.602000													9	44					3.09899e-07	3.2868e-07	0.004482	1	0
GPRC6A	222545	broad.mit.edu	37	6	117128262	117128262	+	Silent	SNP	C	C	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr6:117128262C>G	ENST00000310357.3	-	3	627	c.606G>C	c.(604-606)ctG>ctC	p.L202L	GPRC6A_ENST00000530250.1_Silent_p.L202L|GPRC6A_ENST00000368549.3_Silent_p.L202L	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	202					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ATTTCTGAATCAGGTGAGCCA	0.398000													50	171					0	0	0.014410	0	0
RYR3	6263	broad.mit.edu	37	15	34150099	34150099	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:34150099G>A	ENST00000389232.4	+	99	14196	c.14126G>A	c.(14125-14127)tGc>tAc	p.C4709Y	RYR3_ENST00000415757.3_Missense_Mutation_p.C4704Y	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	4709				C -> R (in Ref. 6; CAA52326).	cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GATATGAAGTGCGACGACATG	0.592000													6	41					0	0	0.021553	0	0
NID2	22795	broad.mit.edu	37	14	52473375	52473375	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr14:52473375G>A	ENST00000216286.5	-	20	3883	c.3884C>T	c.(3883-3885)aCc>aTc	p.T1295I	NID2_ENST00000541773.1_Missense_Mutation_p.T1194I	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	1295						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CAGTTTTTTGGTTCCTTTTAA	0.428000													13	90					0	0	0.024245	0	0
UBA3	9039	broad.mit.edu	37	3	69111272	69111272	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:69111272T>A	ENST00000361055.4	-	10	806	c.752A>T	c.(751-753)gAg>gTg	p.E251V	UBA3_ENST00000415609.2_Missense_Mutation_p.E210V|UBA3_ENST00000540295.1_Missense_Mutation_p.E74V|UBA3_ENST00000349511.4_Missense_Mutation_p.E237V	NM_003968.3	NP_003959.3	Q8TBC4	UBA3_HUMAN	ubiquitin-like modifier activating enzyme 3	251					protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		CCTTACATACTCAATACAGTG	0.343000													20	74					0	0	0.021523	0	0
CYP4F12	66002	broad.mit.edu	37	19	15807840	15807840	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr19:15807840G>A	ENST00000550308.1	+	13	1900	c.1520G>A	c.(1519-1521)cGc>cAc	p.R507H	CYP4F12_ENST00000324632.9_Missense_Mutation_p.R507H	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					TTGATCATGCGCGCCGAGGGC	0.562000													9	41					0	0	0.006214	0	0
CHODL	140578	broad.mit.edu	37	21	19628972	19628972	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr21:19628972G>C	ENST00000299295.2	+	2	617	c.226G>C	c.(226-228)Gaa>Caa	p.E76Q	CHODL_ENST00000338326.3_Missense_Mutation_p.E35Q|CHODL_ENST00000400127.1_Missense_Mutation_p.E35Q|CHODL_ENST00000400128.1_Missense_Mutation_p.E35Q|CHODL_ENST00000400131.1_Missense_Mutation_p.E35Q|CHODL_ENST00000400135.1_Missense_Mutation_p.E35Q|CHODL_ENST00000543733.1_Missense_Mutation_p.E57Q	NM_001204175.1|NM_024944.2	NP_001191104.1|NP_079220.2	Q9H9P2	CHODL_HUMAN	chondrolectin	76	C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		GAATGAAGCAGAACAGAAGTT	0.512000													19	79					0	0	0.008871	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15115677	15115677	+	Missense_Mutation	SNP	C	C	T	rs147577833	byFrequency	TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:15115677C>T	ENST00000253699.3	-	14	2580	c.1967G>A	c.(1966-1968)cGc>cAc	p.R656H	ZFYVE20_ENST00000476527.2_Missense_Mutation_p.R656H	NM_022340.2	NP_071735.2	Q9H1K0	RBNS5_HUMAN	zinc finger, FYVE domain containing 20	656	Necessary for the interaction with EHD1.|Necessary for the interaction with RAB5A.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|skin(3)|stomach(1)|urinary_tract(2)	26						TTTCAGGATGCGGGCTGAAGG	0.562000													4	102					0	0	0.009096	0	0
FBXO44	93611	broad.mit.edu	37	1	11718436	11718436	+	Silent	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:11718436C>T	ENST00000376770.1	+	4	876	c.378C>T	c.(376-378)ttC>ttT	p.F126F	FBXO44_ENST00000376760.1_Intron|FBXO44_ENST00000376762.4_Intron|FBXO44_ENST00000251546.4_Intron|FBXO44_ENST00000251547.5_Silent_p.F126F|FBXO44_ENST00000376768.1_Intron	NM_001014765.1	NP_001014765.1	Q9H4M3	FBX44_HUMAN	F-box protein 44	126	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	8	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		AGAAATACTTCGTTACTTCAT	0.527000													28	81					0	0	0.041601	0	0
RGL4	266747	broad.mit.edu	37	22	24038844	24038844	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr22:24038844G>A	ENST00000290691.5	+	7	2300	c.1130G>A	c.(1129-1131)aGa>aAa	p.R377K	RGL4_ENST00000401461.1_Missense_Mutation_p.R241K	NM_153615.1	NP_705843.1	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation stimulator-like 4	377	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(3)	15						AACCCCCAGAGAGTCCAGATG	0.652000													7	26					0	0	0.006214	0	0
HRNR	388697	broad.mit.edu	37	1	152188507	152188507	+	Silent	SNP	A	A	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:152188507A>T	ENST00000368801.2	-	3	5673	c.5598T>A	c.(5596-5598)ggT>ggA	p.G1866G	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1866					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGAAGACTGACCTGAGCCAG	0.582000													64	1133					0	0	0.042209	0	0
ANKRD30BP3	338579	broad.mit.edu	37	10	45652235	45652235	+	RNA	SNP	C	C	G	rs149362183		TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:45652235C>G	ENST00000427229.2	+	0	1749																											GAAGGAACATCTGAAGGAACA	0.478000													3	26					0	0	0.014758	0	0
PCDH12	51294	broad.mit.edu	37	5	141325324	141325324	+	Silent	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr5:141325324C>T	ENST00000231484.3	-	4	4387	c.3177G>A	c.(3175-3177)gcG>gcA	p.A1059A		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	1059					neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGAGAGTCTCGCCATCCAGG	0.667000													20	56					0	0	0.012319	0	0
PA2G4	5036	broad.mit.edu	37	12	56505295	56505295	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:56505295G>C	ENST00000303305.6	+	12	1520	c.1101G>C	c.(1099-1101)caG>caC	p.Q367H	PA2G4_ENST00000552766.1_Intron|RP11-603J24.17_ENST00000548595.1_RNA	NM_006191.2	NP_006182.2	Q9UQ80	PA2G4_HUMAN	proliferation-associated 2G4, 38kDa	367	Interaction with RNA (By similarity).|Necessary for nucleolar localization.				cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding	p.Q367H(1)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			GAAAAACCCAGAAAAAGAAAA	0.393000													22	104					0	0	0.014323	0	0
FASN	2194	broad.mit.edu	37	17	80045301	80045301	+	Silent	SNP	C	C	T	rs146226779		TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr17:80045301C>T	ENST00000306749.2	-	20	3341	c.3123G>A	c.(3121-3123)tcG>tcA	p.S1041S		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1041					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CGTGCTTGGCCGAGCCCAGGA	0.622000													10	50					0	0	0.010729	0	0
MAP1A	4130	broad.mit.edu	37	15	43816968	43816968	+	Silent	SNP	C	C	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:43816968C>A	ENST00000382031.1	+	5	4042	c.4011C>A	c.(4009-4011)gtC>gtA	p.V1337V	MAP1A_ENST00000300231.5_Silent_p.V1099V|MAP1A_ENST00000399453.1_Silent_p.V1099V			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1099				Missing (in Ref. 4; AAD00355).		cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AAGCAATAGTCTTTGAGATTA	0.547000													18	76					4.54149e-19	5.0461e-19	0.014323	1	0
KNDC1	85442	broad.mit.edu	37	10	135015084	135015084	+	Silent	SNP	C	C	T	rs142572566		TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:135015084C>T	ENST00000304613.3	+	17	3090	c.3069C>T	c.(3067-3069)gaC>gaT	p.D1023D	KNDC1_ENST00000368571.2_Silent_p.D958D|KNDC1_ENST00000368572.2_Silent_p.D1025D			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1023					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TGGACTCGGACGCACTGTCAC	0.627000													13	55					0	0	0.016723	0	0
PABPC3	5042	broad.mit.edu	37	13	25670487	25670487	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr13:25670487T>C	ENST00000281589.3	+	1	188	c.151T>C	c.(151-153)Tcc>Ccc	p.S51P		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	51	RRM 1.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CACCAGCGGCTCCTCCAACTA	0.562000													12	53					0	0	0.013537	0	0
MYB	4602	broad.mit.edu	37	6	135510957	135510957	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr6:135510957G>A	ENST00000341911.5	+	4	441	c.242G>A	c.(241-243)cGa>cAa	p.R81Q	MYB_ENST00000531845.1_3'UTR|MYB_ENST00000528774.1_Missense_Mutation_p.R81Q|MYB_ENST00000420123.2_Missense_Mutation_p.R57Q|MYB_ENST00000525369.1_Missense_Mutation_p.R81Q|MYB_ENST00000316528.8_Missense_Mutation_p.R81Q|MYB_ENST00000527615.1_Missense_Mutation_p.R81Q|MYB_ENST00000533624.1_Missense_Mutation_p.R81Q|MYB_ENST00000442647.2_Missense_Mutation_p.R81Q|MYB_ENST00000534121.1_Missense_Mutation_p.R81Q|MYB_ENST00000534044.1_Missense_Mutation_p.R81Q|MYB_ENST00000367814.4_Missense_Mutation_p.R81Q	NM_001130173.1|NM_001161656.1|NM_001161658.1	NP_001123645.1|NP_001155128.1|NP_001155130.1	P10242	MYB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog	81	HTH myb-type 1.				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		TGCCAGCACCGATGGCAGAAA	0.398000			T	NFIB	adenoid cystic carcinoma								16	98					0	0	0.008871	0	0
LRRK1	79705	broad.mit.edu	37	15	101589973	101589973	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:101589973G>A	ENST00000284395.5	+	24	3815	c.3415G>A	c.(3415-3417)Gat>Aat	p.D1139N	LRRK1_ENST00000388948.3_Missense_Mutation_p.D1142N			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1142					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTCCTTGATTGATCAGTGGTT	0.463000													11	43					0	0	0.016723	0	0
GRIN2D	2906	broad.mit.edu	37	19	48922614	48922614	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr19:48922614A>G	ENST00000263269.3	+	8	1947	c.1859A>G	c.(1858-1860)aAg>aGg	p.K620R		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	620						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	GCCACGGGCAAGCGTGAGTCC	0.597000													7	31					0	0	0.038147	0	0
MYO15A	51168	broad.mit.edu	37	17	18057108	18057108	+	Silent	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr17:18057108G>A	ENST00000205890.5	+	43	8324	c.7986G>A	c.(7984-7986)ctG>ctA	p.L2662L	MYO15A_ENST00000418233.3_5'UTR	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2662	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CGCGATCGCTGGAGCCCCCTG	0.527000													4	33					0	0	0.009096	0	0
FIBCD1	84929	broad.mit.edu	37	9	133805083	133805083	+	Silent	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr9:133805083G>A	ENST00000372338.4	-	2	665	c.423C>T	c.(421-423)gcC>gcT	p.A141A	FIBCD1_ENST00000448616.1_Silent_p.A141A|FIBCD1_ENST00000253018.4_5'UTR|FIBCD1_ENST00000372337.2_5'UTR	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	141					signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		GCAGCTGGTCGGCCAGCGTGT	0.731000													5	9					0	0	0.014758	0	0
ZNF543	125919	broad.mit.edu	37	19	57838010	57838010	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr19:57838010T>C	ENST00000321545.4	+	3	500	c.155T>C	c.(154-156)tTg>tCg	p.L52S		NM_213598.3	NP_998763.2	Q08ER8	ZN543_HUMAN	zinc finger protein 543	52	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(2)|large_intestine(8)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGCTGTCCTTTGTTCAAACCA	0.493000													10	51					0	0	0.013537	0	0
WAPAL	23063	broad.mit.edu	37	10	88277386	88277386	+	Silent	SNP	T	T	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:88277386T>C	ENST00000298767.5	-	2	913	c.441A>G	c.(439-441)acA>acG	p.T147T		NM_015045.2	NP_055860.1	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog (Drosophila)	147	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(6)|lung(13)|ovary(2)|stomach(1)	31						CAATTCGGTTTGTGCTCTTTT	0.363000													3	76					0	0	0.004672	0	0
PA2G4	5036	broad.mit.edu	37	12	56504766	56504766	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:56504766G>C	ENST00000303305.6	+	10	1280	c.861G>C	c.(859-861)aaG>aaC	p.K287N	PA2G4_ENST00000552766.1_Intron|RP11-603J24.17_ENST00000548595.1_RNA	NM_006191.2	NP_006182.2	Q9UQ80	PA2G4_HUMAN	proliferation-associated 2G4, 38kDa	287					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			AAGATGAGAAGAAGGCTCGGA	0.428000													7	39					0	0	0.029380	0	0
TAF7	6879	broad.mit.edu	37	5	140698816	140698816	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr5:140698816C>T	ENST00000313368.5	-	1	1514	c.796G>A	c.(796-798)Gaa>Aaa	p.E266K		NM_005642.2	NP_005633.2	Q15545	TAF7_HUMAN	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	266					negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGCTGTTCATCTGATTCA	0.448000													32	125					0	0	0.013726	0	0
LRRC30	339291	broad.mit.edu	37	18	7231177	7231177	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr18:7231177G>A	ENST00000383467.2	+	1	55	c.41G>A	c.(40-42)gGc>gAc	p.G14D		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	14										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						AAGGATAAGGGCCCCAAGAGG	0.632000													11	73					0	0	0.013537	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60347260	60347260	+	RNA	DEL	T	T	-	rs71816198		TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr17:60347260delT	ENST00000581291.1	-	0	581																				breast(2)|kidney(1)|lung(2)	5						CTCTGAATGATTTTTTTTTTT	0.448													3	3	---	---	---	---					
