Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF184	7738	broad.mit.edu	37	6	27420303	27420303	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:27420303C>G	ENST00000211936.6	-	6	1319	c.1035G>C	c.(1033-1035)caG>caC	p.Q345H	ZNF184_ENST00000377419.1_Missense_Mutation_p.Q345H	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	345					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						AGTGGCCTCTCTGGCTAAAGG	0.423000													6	30					0	0	0.001168	0	0
C2orf44	80304	broad.mit.edu	37	2	24261267	24261267	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:24261267G>C	ENST00000295148.4	-	2	1155	c.1098C>G	c.(1096-1098)atC>atG	p.I366M	C2orf44_ENST00000406895.3_Missense_Mutation_p.I366M	NM_025203.2	NP_079479.1	Q9H6R7	CB044_HUMAN	chromosome 2 open reading frame 44	366							protein binding		C2orf44/ALK(2)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGACAGAGTAGATCAAAATTA	0.393000			T	ALK	NSCLC								20	65					0	0	0.012319	0	0
IVL	3713	broad.mit.edu	37	1	152883939	152883939	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:152883939C>T	ENST00000368764.3	+	2	1730	c.1666C>T	c.(1666-1668)Caa>Taa	p.Q556*	IVL_ENST00000392667.2_Nonsense_Mutation_p.Q410*			P07476	INVO_HUMAN	involucrin	556					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCAAGACATTCAACCAGCCCT	0.592000													19	53					0	0	0.007413	0	0
TAF1L	138474	broad.mit.edu	37	9	32635389	32635389	+	Silent	SNP	C	C	T	rs55895024	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:32635389C>T	ENST00000242310.4	-	1	278	c.189G>A	c.(187-189)aaG>aaA	p.K63K	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	63					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CTGCCAAGTGCTTCTTACACT	0.547000													35	134					0	0	0.013726	0	0
MTHFSD	64779	broad.mit.edu	37	16	86580199	86580199	+	Silent	SNP	T	T	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:86580199T>C	ENST00000322911.6	-	5	455	c.405A>G	c.(403-405)ttA>ttG	p.L135L	MTHFSD_ENST00000360900.6_Silent_p.L136L|MTHFSD_ENST00000546093.1_5'UTR|MTHFSD_ENST00000543303.2_Silent_p.L135L|MTHFSD_ENST00000381214.5_Silent_p.L136L	NM_001159377.1|NM_022764.2	NP_001152849.1|NP_073601.2	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain containing	136					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding			endometrium(1)|large_intestine(3)|lung(6)|skin(1)	11						CCACCACAACTAAATCCACGA	0.537000													3	101					0	0	0.009096	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508040	37508040	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:37508040G>A	ENST00000374660.1	+	40	3688	c.3589G>A	c.(3589-3591)Gag>Aag	p.E1197K	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E1078K|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E1078K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1166						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TAAATACTTTGAGGACATTAA	0.338000													48	88					0	0	0.014410	0	0
RXRG	6258	broad.mit.edu	37	1	165378880	165378880	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:165378880C>T	ENST00000359842.5	-	7	1263	c.961G>A	c.(961-963)Gtg>Atg	p.V321M		NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	321	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CCATCCTGCACGGAAACTGAG	0.532000													8	21					0	0	0.006214	0	0
SRD5A3	79644	broad.mit.edu	37	4	56230347	56230347	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr4:56230347G>C	ENST00000264228.4	+	3	699	c.471G>C	c.(469-471)atG>atC	p.M157I	SRD5A3-AS1_ENST00000433175.2_RNA|SRD5A3_ENST00000514398.1_3'UTR	NM_024592.4	NP_078868.1	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	157					androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor			cervix(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			CCAATGTCATGATTCACGTCG	0.483000													16	72					0	0	0.004007	0	0
USP6	9098	broad.mit.edu	37	17	5048764	5048764	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:5048764G>A	ENST00000574788.1	+	27	4287	c.2057G>A	c.(2056-2058)aGa>aAa	p.R686K	USP6_ENST00000304328.5_Missense_Mutation_p.R369K|USP6_ENST00000250066.6_Missense_Mutation_p.R686K|USP6_ENST00000332776.4_Missense_Mutation_p.R686K			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	686					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						GGGCAGCTAAGATCTCAAGTC	0.373000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								19	47					0	0	0.007413	0	0
MUC5B	727897	broad.mit.edu	37	11	1271273	1271273	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:1271273C>T	ENST00000447027.1	+	31	13230	c.13172C>T	c.(13171-13173)aCg>aTg	p.T4391M	MUC5B_ENST00000529681.1_Missense_Mutation_p.T4388M			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4388	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACTCCGGGGACGACCTGGATC	0.662000													55	129					0	0	0.014410	0	0
LLGL1	3996	broad.mit.edu	37	17	18144788	18144788	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:18144788C>T	ENST00000316843.4	+	18	2622	c.2526C>T	c.(2524-2526)agC>agT	p.S842S		NM_004140.3	NP_004131.3	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	842					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					CCAAGGTGAGCGCGAAGACCA	0.632000													11	29					0	0	0.008291	0	0
IPO13	9670	broad.mit.edu	37	1	44415762	44415762	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:44415762C>T	ENST00000372343.3	+	2	1420	c.758C>T	c.(757-759)tCg>tTg	p.S253L		NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	253					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CTGCAGGACTCGGAGCTCTTC	0.577000													12	27					0	0	0.010729	0	0
AK1	203	broad.mit.edu	37	9	130630646	130630646	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:130630646G>A	ENST00000373176.1	-	6	622	c.470C>T	c.(469-471)aCa>aTa	p.T157I	AK1_ENST00000373156.1_Missense_Mutation_p.T157I|RP11-203J24.9_ENST00000476274.2_RNA|AK1_ENST00000223836.10_Missense_Mutation_p.T173I	NM_000476.2	NP_000467.1	P00568	KAD1_HUMAN	adenylate kinase 1	157					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding			endometrium(1)|prostate(1)	2						GACAGGTTCTGTGGCCTTGTA	0.592000													10	17					0	0	0.008291	0	0
MAN1A1	4121	broad.mit.edu	37	6	119501047	119501047	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:119501047G>A	ENST00000368468.3	-	13	2340	c.1899C>T	c.(1897-1899)agC>agT	p.S633S		NM_005907.3	NP_005898.2	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	633					post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|skin(3)	24		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		GATGTGCCTCGCTATTGAAGA	0.378000													9	39					0	0	0.013537	0	0
OR4K2	390431	broad.mit.edu	37	14	20345329	20345329	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr14:20345329G>C	ENST00000298642.2	+	1	939	c.903G>C	c.(901-903)ctG>ctC	p.L301L		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGAGGAAACTGAAAAATAGGT	0.348000													20	20					0	0	0.010504	0	0
VCAN	1462	broad.mit.edu	37	5	82808041	82808041	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:82808041G>A	ENST00000265077.3	+	6	1433	c.868G>A	c.(868-870)Ggc>Agc	p.G290S	VCAN_ENST00000502527.2_Missense_Mutation_p.G290S|VCAN_ENST00000343200.5_Missense_Mutation_p.G290S|VCAN_ENST00000512590.2_Missense_Mutation_p.G242S|VCAN_ENST00000513984.1_Missense_Mutation_p.G290S|VCAN_ENST00000342785.4_Missense_Mutation_p.G290S	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	290	Link 2.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding	p.G290S(1)		NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ATGGAGGAACGGCTTTGACCA	0.602000													15	26					0	0	0.004007	0	0
PRRT3	285368	broad.mit.edu	37	3	9989488	9989488	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:9989488G>A	ENST00000412055.1	-	4	1498	c.1369C>T	c.(1369-1371)Ccg>Tcg	p.P457S	PRRT3-AS1_ENST00000431558.1_RNA	NM_207351.3	NP_997234.3	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3	457	Pro-rich.					integral to membrane				NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)|stomach(2)	13						CAGCGTAGCGGGGGTGCAGTG	0.716000													3	5					0	0	0.004672	0	0
TLN1	7094	broad.mit.edu	37	9	35715166	35715166	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:35715166C>T	ENST00000314888.9	-	21	2997	c.2644G>A	c.(2644-2646)Gac>Aac	p.D882N	TLN1_ENST00000540444.1_Missense_Mutation_p.D882N	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	882					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCCTCACTGTCAGGGTGGGCA	0.592000													10	93					0	0	0.008291	0	0
C5	727	broad.mit.edu	37	9	123731393	123731393	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:123731393G>C	ENST00000223642.1	-	33	4195	c.4166C>G	c.(4165-4167)tCc>tGc	p.S1389C		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1389					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TCTGTAGTGGGATGCTGGCAC	0.413000													15	106					0	0	0.004007	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128838895	128838895	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:128838895C>G	ENST00000310343.9	-	22	6170	c.6171G>C	c.(6169-6171)caG>caC	p.Q2057H	ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.Q1708H|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.Q1708H	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	2057	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						AGGTCCTGCTCTGTGGATGGG	0.587000													7	25					0	0	0.001984	0	0
RNF10	9921	broad.mit.edu	37	12	120972767	120972767	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:120972767G>C	ENST00000325954.4	+	1	614	c.153G>C	c.(151-153)aaG>aaC	p.K51N	RNF10_ENST00000413266.2_Missense_Mutation_p.K51N	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	51	Ser-rich.				negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTAAACCCAAGAGCGGTAAGG	0.701000													8	26					0	0	0.006214	0	0
SEC24A	10802	broad.mit.edu	37	5	134007526	134007526	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:134007526C>G	ENST00000398844.2	+	4	1055	c.767C>G	c.(766-768)tCt>tGt	p.S256C	SEC24A_ENST00000322887.4_Missense_Mutation_p.S256C	NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	256					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding	p.S256F(1)		NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AATAACGGATCTATGGTGGTC	0.308000													12	27					0	0	0.002450	0	0
MYLK4	340156	broad.mit.edu	37	6	2675332	2675332	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:2675332G>C	ENST00000274643.7	-	11	1410	c.1068C>G	c.(1066-1068)ctC>ctG	p.L356L	MYLK4_ENST00000268446.5_Silent_p.L356L	NM_001012418.3	NP_001012418.2	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	356	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				AGGGGTGCTTGAGAGCTTCGC	0.488000													25	66					0	0	0.007291	0	0
RUVBL2	10856	broad.mit.edu	37	19	49507659	49507659	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:49507659G>C	ENST00000413176.2	+	4	1262	c.114G>C	c.(112-114)aaG>aaC	p.K38N	RUVBL2_ENST00000601968.1_Missense_Mutation_p.K38N|RUVBL2_ENST00000595090.1_Missense_Mutation_p.K83N			Q9Y230	RUVB2_HUMAN	RuvB-like AAA ATPase 2	83					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding			large_intestine(1)|upper_aerodigestive_tract(1)	2		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		GCACGGGGAAGACGGCCATCG	0.622000													14	60					0	0	0.002450	0	0
MAP10	54627	broad.mit.edu	37	1	232941709	232941709	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:232941709A>G	ENST00000418460.1	+	1	1067	c.940A>G	c.(940-942)Act>Gct	p.T314A		NM_019090.2	NP_061963.2			microtubule-associated protein 10																		GGGCGAGCGGACTGGGGACAT	0.692000													10	17					0	0	0.010729	0	0
PQLC1	80148	broad.mit.edu	37	18	77710917	77710917	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr18:77710917C>G	ENST00000397778.2	-	2	192	c.10G>C	c.(10-12)Gag>Cag	p.E4Q	PQLC1_ENST00000590381.1_Missense_Mutation_p.E4Q|PQLC1_ENST00000357575.4_Missense_Mutation_p.E4Q	NM_025078.4	NP_079354.2	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1	4						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	9		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		TCCAGGCCCTCGGCCTCCATC	0.766000													3	6					0	0	0.004672	0	0
FLG	2312	broad.mit.edu	37	1	152276170	152276170	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:152276170G>A	ENST00000368799.1	-	3	11227	c.11192C>T	c.(11191-11193)aCt>aTt	p.T3731I	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3731	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTTCCTCCAGTACTGGGCCC	0.617000									Ichthyosis				139	307					0	0	0.014410	0	0
MYCBP2	23077	broad.mit.edu	37	13	77715011	77715011	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr13:77715011G>C	ENST00000407578.2	-	50	7637	c.7371C>G	c.(7369-7371)gtC>gtG	p.V2457V	MYCBP2_ENST00000357337.6_Silent_p.V2419V|MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000544440.2_Silent_p.V2419V	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	2419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ACTTTGGTTTGACCAACTGAG	0.408000													66	179					0	0	0.014410	0	0
TTLL11	158135	broad.mit.edu	37	9	124751422	124751422	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:124751422T>A	ENST00000373776.3	-	4	1778	c.1591A>T	c.(1591-1593)Agg>Tgg	p.R531W	TTLL11_ENST00000474723.1_Intron|TTLL11_ENST00000321582.5_Intron	NM_194252.2	NP_919228.2	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	531	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(3)|skin(1)	18						CAGAGAGCCCTCTTGAGGCCG	0.627000													29	113					0	0	0.012213	0	0
SMARCE1	6605	broad.mit.edu	37	17	38785063	38785063	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:38785063T>C	ENST00000348513.6	-	11	1990	c.1210A>G	c.(1210-1212)Ata>Gta	p.I404V	SMARCE1_ENST00000580419.1_Missense_Mutation_p.I369V|SMARCE1_ENST00000578044.1_Missense_Mutation_p.I334V|SMARCE1_ENST00000544009.1_Missense_Mutation_p.I334V|KRT222_ENST00000476049.1_3'UTR|SMARCE1_ENST00000400122.3_3'UTR|SMARCE1_ENST00000431889.2_Missense_Mutation_p.I386V|SMARCE1_ENST00000377808.4_3'UTR	NM_003079.4	NP_003070.3	Q969G3	SMCE1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	404	Glu-rich.				chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity			large_intestine(1)	1		Breast(137;0.000812)				TCTTCTGGTATGGGATCTGTT	0.418000													64	131					0	0	0.014410	0	0
ALK	238	broad.mit.edu	37	2	29443686	29443686	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:29443686C>G	ENST00000389048.3	-	23	4437	c.3531G>C	c.(3529-3531)caG>caC	p.Q1177H	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1177	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GAACAATGTTCTGGTGGTTGA	0.517000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				13	28					0	0	0.001855	0	0
GPR83	10888	broad.mit.edu	37	11	94134045	94134045	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:94134045G>C	ENST00000243673.2	-	1	540	c.369C>G	c.(367-369)ctC>ctG	p.L123L	GPR83_ENST00000539203.2_Silent_p.L123L	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	123						integral to membrane|plasma membrane	neuropeptide Y receptor activity	p.L123L(1)		NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				AGGGGGTGTTGAGCAGCGTGA	0.572000													12	28					0	0	0.010729	0	0
TMEM131	23505	broad.mit.edu	37	2	98408979	98408979	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:98408979C>T	ENST00000186436.5	-	31	4242	c.4014G>A	c.(4012-4014)gcG>gcA	p.A1338A		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1338						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						AACTGTGCCTCGCGCTGCTGG	0.622000													5	22					0	0	0.003080	0	0
PRRC2B	84726	broad.mit.edu	37	9	134321939	134321939	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:134321939C>T	ENST00000357304.4	+	6	820	c.765C>T	c.(763-765)ctC>ctT	p.L255L	PRRC2B_ENST00000405995.1_Silent_p.L255L|PRRC2B_ENST00000458550.1_Silent_p.L255L	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	255							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						ACCCCTCTCTCCGCCCGGCTC	0.562000													5	48					0	0	0.000602	0	0
C9orf135	138255	broad.mit.edu	37	9	72471558	72471558	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:72471558G>A	ENST00000377197.3	+	3	436	c.349G>A	c.(349-351)Gag>Aag	p.E117K	C9orf135_ENST00000527647.1_Missense_Mutation_p.E117K|C9orf135_ENST00000466872.2_3'UTR	NM_001010940.1	NP_001010940.1	Q5VTT2	CI135_HUMAN	chromosome 9 open reading frame 135	117						integral to membrane				endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						TTTATTGAATGAGGAAACAGT	0.348000													8	69					0	0	0.004482	0	0
SSX1	6756	broad.mit.edu	37	X	48123288	48123288	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chrX:48123288C>T	ENST00000376919.3	+	6	538	c.402C>T	c.(400-402)aaC>aaT	p.N134N		NM_001278691.1|NM_005635.2	NP_001265620.1|NP_005626.1	Q16384	SSX1_HUMAN	synovial sarcoma, X breakpoint 1	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|transcription corepressor activity		SS18/SSX1(1169)|SS18L1/SSX1(2)	endometrium(2)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9						GCCCACAAAACGATGGGAAAC	0.423000			T	SS18	synovial sarcoma								82	59					0	0	0.014410	0	0
RNF167	26001	broad.mit.edu	37	17	4847869	4847869	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:4847869C>T	ENST00000262482.6	+	9	1343	c.687C>T	c.(685-687)gtC>gtT	p.V229V	RNF167_ENST00000575111.1_Silent_p.V229V|RNF167_ENST00000572430.1_Silent_p.V229V|RNF167_ENST00000570492.1_3'UTR|RNF167_ENST00000576229.1_Silent_p.V194V|RNF167_ENST00000571816.1_Silent_p.V229V	NM_015528.1	NP_056343.1	Q9H6Y7	RN167_HUMAN	ring finger protein 167	229					negative regulation of cell cycle|protein polyubiquitination	cytoplasm|endomembrane system|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(1)	4						AGTATGATGTCTGTGCCATTT	0.517000													20	84					0	0	0.008871	0	0
NCR2	9436	broad.mit.edu	37	6	41318601	41318601	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:41318601G>A	ENST00000373089.5	+	5	918	c.830G>A	c.(829-831)tGa>tAa	p.*277*	NCR2_ENST00000373086.3_3'UTR	NM_004828.3	NP_004819.2	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	0					cellular defense response	integral to plasma membrane	transmembrane receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	14	Ovarian(28;0.0327)|Colorectal(47;0.196)					cacactttgtgaataataaaa	0.393000													15	39					0	0	0.002450	0	0
PDE8A	5151	broad.mit.edu	37	15	85669605	85669605	+	Splice_Site	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:85669605G>A	ENST00000310298.4	+	21	2505	c.2253_splice	c.e21+1	p.Q751_splice	PDE8A_ENST00000557957.1_Splice_Site_p.Q679_splice|PDE8A_ENST00000339708.5_Splice_Site_p.Q705_splice|PDE8A_ENST00000394553.1_Splice_Site_p.Q751_splice			O60658	PDE8A_HUMAN	phosphodiesterase 8A	751	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	25	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			ATTTTTCTCAGGTAAGTTGCT	0.418000													18	58					0	0	0.006122	0	0
ZNF438	220929	broad.mit.edu	37	10	31139092	31139092	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:31139092G>A	ENST00000538351.1	-	7	849	c.95C>T	c.(94-96)gCc>gTc	p.A32V	ZNF438_ENST00000452305.1_Missense_Mutation_p.A71V|ZNF438_ENST00000413025.1_Missense_Mutation_p.A81V|ZNF438_ENST00000442986.1_Missense_Mutation_p.A81V|ZNF438_ENST00000375311.1_Intron|ZNF438_ENST00000361310.3_Missense_Mutation_p.A81V|ZNF438_ENST00000331737.6_Missense_Mutation_p.A71V|ZNF438_ENST00000444692.2_Missense_Mutation_p.A71V|ZNF438_ENST00000436087.2_Missense_Mutation_p.A81V	NM_001143769.1	NP_001137241.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				CTGCATCAGGGCATAGTTCTG	0.532000													4	116					0	0	0.009096	0	0
DGKB	1607	broad.mit.edu	37	7	14378224	14378224	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:14378224G>A	ENST00000403951.2	-	23	2460	c.2041C>T	c.(2041-2043)Cga>Tga	p.R681*	DGKB_ENST00000406247.3_Nonsense_Mutation_p.R681*|DGKB_ENST00000258767.5_Nonsense_Mutation_p.R681*|DGKB_ENST00000402815.1_Nonsense_Mutation_p.R680*|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000399322.3_Nonsense_Mutation_p.R681*|DGKB_ENST00000444700.2_Nonsense_Mutation_p.R662*|DGKB_ENST00000407950.1_Nonsense_Mutation_p.R673*			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	681					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding	p.R681*(2)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CGATGGCTTCGTCTTTTCTTA	0.398000													30	68					0	0	0.009535	0	0
SP140	11262	broad.mit.edu	37	2	231112687	231112687	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:231112687G>A	ENST00000392045.3	+	8	913	c.799G>A	c.(799-801)Gag>Aag	p.E267K	SP140_ENST00000417495.3_Intron|SP140_ENST00000350136.5_Intron|SP140_ENST00000343805.6_Missense_Mutation_p.E241K|SP140_ENST00000420434.3_Missense_Mutation_p.E267K|SP140_ENST00000486687.2_Intron	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	267					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGCACCAGGGGAGAAACAGGG	0.473000													46	38					0	0	0.009718	0	0
TRPV1	7442	broad.mit.edu	37	17	3475479	3475479	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:3475479G>A	ENST00000174621.6	-	13	2451	c.2162C>T	c.(2161-2163)tCa>tTa	p.S721L	TRPV1_ENST00000425167.2_Missense_Mutation_p.S734L|TRPV1_ENST00000399756.4_Missense_Mutation_p.S723L|SHPK_ENST00000572705.1_Missense_Mutation_p.S723L|TRPV1_ENST00000310522.5_Missense_Mutation_p.S663L|TRPV1_ENST00000571088.1_Missense_Mutation_p.S723L|TRPV1_ENST00000576351.1_Missense_Mutation_p.S713L|TRPV1_ENST00000399759.3_Missense_Mutation_p.S723L			Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel, subfamily V, member 1	723					cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	17				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	CAGCTTGCCTGAGCGGAAGGC	0.592000													7	22					0	0	0.001984	0	0
SHMT1	6470	broad.mit.edu	37	17	18244076	18244076	+	Missense_Mutation	SNP	G	G	A	rs148701087	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:18244076G>A	ENST00000316694.3	-	6	705	c.571C>T	c.(571-573)Cgc>Tgc	p.R191C	SHMT1_ENST00000539052.1_Missense_Mutation_p.R53C|SHMT1_ENST00000354098.3_Missense_Mutation_p.R191C|SHMT1_ENST00000352886.6_Missense_Mutation_p.R191C	NM_004169.3	NP_004160.3	P34896	GLYC_HUMAN	serine hydroxymethyltransferase 1 (soluble)	191					carnitine biosynthetic process|folic acid metabolic process|L-serine catabolic process|one-carbon metabolic process|purine base biosynthetic process	cytosol|nucleus	glycine hydroxymethyltransferase activity|protein homodimerization activity|pyridoxal phosphate binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)	13					Glycine(DB00145)|Mimosine(DB01055)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	TGGAAGAGGCGTGCGTTCTCC	0.557000													5	12					0	0	0.000602	0	0
MYLK	4638	broad.mit.edu	37	3	123383036	123383036	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:123383036G>A	ENST00000360772.3	-	24	4279	c.3901C>T	c.(3901-3903)Cgc>Tgc	p.R1301C	MYLK_ENST00000475616.1_Missense_Mutation_p.R1301C|MYLK_ENST00000359169.1_Missense_Mutation_p.R1301C|MYLK_ENST00000360304.3_Missense_Mutation_p.R1301C|MYLK_ENST00000354792.5_Missense_Mutation_p.R101C|MYLK_ENST00000346322.5_Missense_Mutation_p.R1232C			Q15746	MYLK_HUMAN	myosin light chain kinase	1301	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 8.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TGCTCCTGGCGCGCGGCCAGG	0.627000													51	171					0	0	0.014410	0	0
CYP2C8	1558	broad.mit.edu	37	10	96818118	96818118	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:96818118C>G	ENST00000371270.3	-	5	887	c.793G>C	c.(793-795)Gat>Cat	p.D265H	CYP2C8_ENST00000535898.1_Missense_Mutation_p.D163H|CYP2C8_ENST00000539050.1_Missense_Mutation_p.D179H	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	265					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding	p.D265N(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	AGGAAGCAATCGATAAAGTCC	0.358000													4	58					0	0	0.009096	0	0
ZNF621	285268	broad.mit.edu	37	3	40570902	40570902	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:40570902G>A	ENST00000339296.5	+	3	569	c.117G>A	c.(115-117)gtG>gtA	p.V39V	ZNF621_ENST00000490457.1_3'UTR|ZNF621_ENST00000403205.2_Silent_p.V39V|ZNF621_ENST00000310898.1_Silent_p.V39V|ZNF621_ENST00000431278.1_Intron	NM_198484.3	NP_940886.1	Q6ZSS3	ZN621_HUMAN	zinc finger protein 621	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0515)|Kidney(284;0.0648)		ACGGGGAGGTGATGCTGGAGA	0.517000													57	85					0	0	0.014410	0	0
LYZL2	119180	broad.mit.edu	37	10	30900884	30900884	+	Nonstop_Mutation	SNP	T	T	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:30900884T>A	ENST00000375318.2	-	5	641	c.585A>T	c.(583-585)taA>taT	p.*195Y		NM_183058.2	NP_898881.2	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	0					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			NS(2)|central_nervous_system(1)|large_intestine(1)|lung(14)|prostate(1)	19		Prostate(175;0.151)				CAGTTCCAGTTTAGGAAACCT	0.517000													81	156					0	0	0.014410	0	0
MAP1B	4131	broad.mit.edu	37	5	71491499	71491499	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:71491499G>A	ENST00000296755.7	+	5	2615	c.2317G>A	c.(2317-2319)Gcc>Acc	p.A773T		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	773	Lys-rich (highly basic, contains many KKEE and KKEI/V repeats).					microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TTCTGTTGCTGCCGGAAAGCC	0.473000													37	124					0	0	0.004878	0	0
LRSAM1	90678	broad.mit.edu	37	9	130257620	130257620	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:130257620G>A	ENST00000323301.4	+	21	2225	c.1621G>A	c.(1621-1623)Gaa>Aaa	p.E541K	LRSAM1_ENST00000300417.6_Missense_Mutation_p.E541K|LRSAM1_ENST00000373322.1_Missense_Mutation_p.E541K|LRSAM1_ENST00000373324.4_Missense_Mutation_p.E514K|LRSAM1_ENST00000483302.1_3'UTR	NM_138361.5	NP_612370.3	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif containing 1	541					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(2)	16						AGCCAAAAGTGAAACCAGGCA	0.468000													8	46					0	0	0.004482	0	0
LZTR1	8216	broad.mit.edu	37	22	21348988	21348988	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr22:21348988C>T	ENST00000215739.8	+	15	2116	c.1757C>T	c.(1756-1758)gCc>gTc	p.A586V	LZTR1_ENST00000479606.1_3'UTR|LZTR1_ENST00000389355.3_Missense_Mutation_p.A567V	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	586					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGCGAGAGTGCCGCCCGGCTG	0.657000													3	31					0	0	0.004672	0	0
FAM53B	9679	broad.mit.edu	37	10	126311927	126311927	+	Missense_Mutation	SNP	C	C	T	rs140442850	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:126311927C>T	ENST00000337318.3	-	5	1364	c.1153G>A	c.(1153-1155)Gag>Aag	p.E385K	FAM53B_ENST00000392754.3_Missense_Mutation_p.E385K|RP11-12J10.3_ENST00000494792.1_Intron	NM_014661.3	NP_055476.3	Q14153	FA53B_HUMAN	family with sequence similarity 53, member B	385										cervix(1)|lung(5)|ovary(2)|pancreas(1)	9		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		CCACAATCCTCGTCCAGGGCG	0.682000													7	25					0	0	0.004482	0	0
DGKE	8526	broad.mit.edu	37	17	54940147	54940147	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:54940147G>T	ENST00000284061.3	+	12	1879	c.1699G>T	c.(1699-1701)Gaa>Taa	p.E567*		NM_003647.2	NP_003638.1	P52429	DGKE_HUMAN	diacylglycerol kinase, epsilon 64kDa	567					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(3)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25	Breast(9;3.59e-07)					AAAGGCGACTGAATAGATGGA	0.358000													10	17					2.17888e-05	3.59801e-05	0.006214	1	0
SMEK2	57223	broad.mit.edu	37	2	55812192	55812192	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:55812192C>T	ENST00000272313.5	-	7	1555	c.1228G>A	c.(1228-1230)Gat>Aat	p.D410N	SMEK2_ENST00000407823.3_Missense_Mutation_p.D410N|SMEK2_ENST00000345102.5_Missense_Mutation_p.D410N	NM_020463.2	NP_065196.1	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 (Dictyostelium)	410						microtubule organizing center|nucleus	protein binding	p.D410N(1)		kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	16			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CTTACGTCATCACTCTGCTGA	0.348000													15	48					0	0	0.004007	0	0
NCOA7	135112	broad.mit.edu	37	6	126210917	126210917	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:126210917G>A	ENST00000368357.3	+	10	2069	c.1717G>A	c.(1717-1719)Gag>Aag	p.E573K	NCOA7_ENST00000392477.2_Missense_Mutation_p.E573K|NCOA7_ENST00000229634.9_Missense_Mutation_p.E458K	NM_001199619.1|NM_001199620.1	NP_001186548.1|NP_001186549.1	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7	573					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(2)	39				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		TCCCATAACTGAGGGCAATAA	0.438000													13	43					0	0	0.001855	0	0
SIRT3	23410	broad.mit.edu	37	11	233115	233115	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:233115A>G	ENST00000382743.4	-	3	676	c.574T>C	c.(574-576)Ttt>Ctt	p.F192L	SIRT3_ENST00000524564.1_Missense_Mutation_p.F128L|SIRT3_ENST00000529382.1_Missense_Mutation_p.F50L|SIRT3_ENST00000525319.1_Missense_Mutation_p.F111L|SIRT3_ENST00000532956.1_Missense_Mutation_p.F192L|SIRT3_ENST00000528702.1_5'UTR	NM_001017524.2|NM_012239.5	NP_001017524.1|NP_036371.1	Q9NTG7	SIRT3_HUMAN	sirtuin 3	192	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			endometrium(1)|lung(5)|urinary_tract(1)	7		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.66e-27)|Epithelial(43;2.02e-26)|OV - Ovarian serous cystadenocarcinoma(40;2.9e-21)|BRCA - Breast invasive adenocarcinoma(625;3.88e-05)|Lung(200;0.111)|LUSC - Lung squamous cell carcinoma(625;0.129)		AAAGTGAAAAAGGGCTTGGGG	0.547000													3	61					0	0	0.004672	0	0
ZC3H3	23144	broad.mit.edu	37	8	144557590	144557590	+	Silent	SNP	G	G	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr8:144557590G>T	ENST00000262577.5	-	5	1912	c.1881C>A	c.(1879-1881)ggC>ggA	p.G627G		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	627					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			GGGGCCTGCTGCCCGCATCAC	0.657000													13	37					4.36969e-10	7.46117e-10	0.001855	1	0
LOC101926911	101926911	broad.mit.edu	37	15	91573318	91573318	+	RNA	SNP	A	A	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:91573318A>G	ENST00000557804.1	+	0	243				AC068831.10_ENST00000556904.1_RNA|AC068831.10_ENST00000501381.3_RNA																							AACGATGGGGACTTTGAGAGA	0.368000													7	7					0	0	0.001984	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203521	140203521	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:140203521C>T	ENST00000529859.1	+	1	2161	c.2161C>T	c.(2161-2163)Cgg>Tgg	p.R721W	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.R721W|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.R721W|PCDHA1_ENST00000394633.3_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCGCGCTGCGGTGCTCGGC	0.667000													33	69					0	0	0.012213	0	0
TRPC1	7220	broad.mit.edu	37	3	142523281	142523281	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:142523281C>T	ENST00000273482.6	+	11	2252	c.1861C>T	c.(1861-1863)Cat>Tat	p.H621Y	TRPC1_ENST00000476941.1_Missense_Mutation_p.H655Y	NM_003304.4	NP_003295.1	P48995	TRPC1_HUMAN	transient receptor potential cation channel, subfamily C, member 1	655					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(2)|stomach(3)|urinary_tract(1)	37						TATATAGAATCATGAAGACAA	0.348000													14	22					0	0	0.002450	0	0
IARS	3376	broad.mit.edu	37	9	95043130	95043130	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:95043130C>G	ENST00000375643.3	-	7	909	c.643G>C	c.(643-645)Gat>Cat	p.D215H	IARS_ENST00000375629.3_5'UTR|IARS_ENST00000447699.2_Missense_Mutation_p.D105H|IARS_ENST00000443024.2_Missense_Mutation_p.D215H	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase	215					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	ACAGTTTCATCTTCTTCCAAA	0.353000													4	52					0	0	0.009096	0	0
OR10J5	127385	broad.mit.edu	37	1	159505792	159505792	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:159505792C>G	ENST00000334857.2	-	1	50	c.6G>C	c.(4-6)aaG>aaC	p.K2N		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					AGTTCTTTCTCTTCATTCTGC	0.348000													14	32					0	0	0.002450	0	0
ANAPC15	25906	broad.mit.edu	37	11	71822259	71822259	+	Silent	SNP	G	G	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:71822259G>T	ENST00000227618.4	-	3	289	c.64C>A	c.(64-66)Cga>Aga	p.R22R	ANAPC15_ENST00000535503.1_Silent_p.R22R|ANAPC15_ENST00000543587.1_Silent_p.R22R|ANAPC15_ENST00000542531.1_Silent_p.R22R|ANAPC15_ENST00000543050.1_Silent_p.R22R|ANAPC15_ENST00000535234.1_Silent_p.R22R|ANAPC15_ENST00000502597.2_Intron|ANAPC15_ENST00000545944.1_Silent_p.R22R|ANAPC15_ENST00000538919.1_Silent_p.R22R|ANAPC15_ENST00000538393.1_Silent_p.R22R|ANAPC15_ENST00000545680.1_Silent_p.R22R	NM_001278487.1|NM_001278491.1|NM_014042.2	NP_001265416.1|NP_001265420.1|NP_054761.1			anaphase promoting complex subunit 15																		ACACAGGGTCGATCCAGATTA	0.542000													37	67					2.42023e-17	4.1895e-17	0.003271	1	0
TAF2	6873	broad.mit.edu	37	8	120818639	120818639	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr8:120818639C>T	ENST00000378164.2	-	4	600	c.302G>A	c.(301-303)aGa>aAa	p.R101K		NM_003184.3	NP_003175.1	Q6P1X5	TAF2_HUMAN	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	101					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(2)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(21)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	49	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ATTGAGGTTTCTCCTGGGGAA	0.348000													18	64					0	0	0.004990	0	0
ATP1A2	477	broad.mit.edu	37	1	160109482	160109482	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:160109482C>A	ENST00000361216.3	+	21	2982	c.2893C>A	c.(2893-2895)Ctc>Atc	p.L965I	ATP1A2_ENST00000392233.3_Missense_Mutation_p.L965I	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	965					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GGCTGCCTTTCTCTCTTACTG	0.582000													18	51					6.49762e-13	1.11706e-12	0.006122	1	0
LRFN2	57497	broad.mit.edu	37	6	40359913	40359913	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:40359913C>T	ENST00000338305.6	-	3	2681	c.2139G>A	c.(2137-2139)ccG>ccA	p.P713P		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	713						cell junction|integral to membrane|postsynaptic membrane		p.P713P(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGCCCTCCAACGGCAAGGGGA	0.736000													5	14					0	0	0.000602	0	0
ARID3C	138715	broad.mit.edu	37	9	34623560	34623560	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:34623560G>A	ENST00000378909.2	-	4	819	c.727C>T	c.(727-729)Cgg>Tgg	p.R243W		NM_001017363.1	NP_001017363.1	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT-like)	243	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	14	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		TGAGCGCCCCGAGGGGGCGGC	0.746000													7	42					0	0	0.003080	0	0
ZNF668	79759	broad.mit.edu	37	16	31073297	31073297	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:31073297G>A	ENST00000538906.1	-	3	1736	c.952C>T	c.(952-954)Cgg>Tgg	p.R318W	ZNF668_ENST00000417110.2_Missense_Mutation_p.R162Q|ZNF668_ENST00000535577.1_Missense_Mutation_p.R318W|ZNF668_ENST00000394983.2_Missense_Mutation_p.R318W|ZNF668_ENST00000300849.4_Missense_Mutation_p.R318W|ZNF668_ENST00000426488.2_Missense_Mutation_p.R341W|ZNF668_ENST00000539836.3_Missense_Mutation_p.R341W	NM_001172668.1	NP_001166139.1	Q96K58	ZN668_HUMAN	zinc finger protein 668	318					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						GCCGGCTGCCGGAAGTCCTTG	0.662000													10	34					0	0	0.006214	0	0
SMARCA4	6597	broad.mit.edu	37	19	11132522	11132522	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:11132522C>T	ENST00000358026.2	+	19	3022	c.2738C>T	c.(2737-2739)cCg>cTg	p.P913L	SMARCA4_ENST00000344626.4_Missense_Mutation_p.P913L|SMARCA4_ENST00000444061.3_Missense_Mutation_p.P913L|SMARCA4_ENST00000450717.3_Missense_Mutation_p.P913L|SMARCA4_ENST00000413806.3_Missense_Mutation_p.P913L|SMARCA4_ENST00000590574.1_Missense_Mutation_p.P913L|SMARCA4_ENST00000589677.1_Missense_Mutation_p.P913L|SMARCA4_ENST00000541122.2_Missense_Mutation_p.P913L|SMARCA4_ENST00000429416.3_Missense_Mutation_p.P913L	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	913	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.P913Q(2)|p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				ACGGGCACACCGCTGCAGAAC	0.612000			"""F, N, Mis"""		NSCLC								12	44					0	0	0.010729	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735144	140735144	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:140735144T>C	ENST00000571252.1	+	1	377	c.377T>C	c.(376-378)gTt>gCt	p.V126A	PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAATCGATGTTAATGATAAC	0.423000													19	36					0	0	0.012319	0	0
ITGB4	3691	broad.mit.edu	37	17	73751885	73751885	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:73751885G>A	ENST00000200181.3	+	35	4849	c.4662G>A	c.(4660-4662)gaG>gaA	p.E1554E	GALK1_ENST00000225614.2_Intron|ITGB4_ENST00000449880.2_Silent_p.E1537E|ITGB4_ENST00000339591.3_Silent_p.E1537E|ITGB4_ENST00000579662.1_Silent_p.E1484E|ITGB4_ENST00000450894.3_Silent_p.E1484E	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1554	Fibronectin type-III 3.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGCGGTGCGAGCGGCCGCTGC	0.701000													11	25					0	0	0.008291	0	0
TJP1	7082	broad.mit.edu	37	15	30011032	30011032	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:30011032G>C	ENST00000346128.6	-	21	3788	c.3314C>G	c.(3313-3315)cCt>cGt	p.P1105R	TJP1_ENST00000400011.2_Missense_Mutation_p.P1029R|TJP1_ENST00000356107.6_Missense_Mutation_p.P1105R|TJP1_ENST00000545208.2_Missense_Mutation_p.P1025R	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	1105					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		ATTATCAAAAGGTGGCCGAGA	0.493000													4	162					0	0	0.009096	0	0
OR52H1	390067	broad.mit.edu	37	11	5566547	5566547	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:5566547G>C	ENST00000322653.4	-	1	232	c.207C>G	c.(205-207)ttC>ttG	p.F69L	HBG2_ENST00000380259.2_Intron	NM_001005289.1	NP_001005289.1	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H, member 1	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGAGAGAAAGAAGAACATGG	0.473000													19	55					0	0	0.006122	0	0
DSCAM	1826	broad.mit.edu	37	21	41710050	41710050	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr21:41710050C>G	ENST00000400454.1	-	8	2238	c.1761G>C	c.(1759-1761)caG>caC	p.Q587H		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	587	Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CGTGGACGCTCTGGCTGGTGG	0.507000													12	102					0	0	0.010729	0	0
GGTLC1	92086	broad.mit.edu	37	20	23966391	23966391	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:23966391G>A	ENST00000335694.4	-	5	648	c.444C>T	c.(442-444)ggC>ggT	p.G148G	GGTLC1_ENST00000278765.4_Silent_p.G148G|GGTLC1_ENST00000286890.4_Silent_p.G148G	NM_178311.2	NP_842563.1	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	148							gamma-glutamyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15						TCACGTCATAGCCGAACCAGA	0.612000													38	142					0	0	0.006230	0	0
HLA-A	3105	broad.mit.edu	37	6	29910349	29910349	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:29910349C>T	ENST00000396634.1	+	3	360	c.19C>T	c.(19-21)Cga>Tga	p.R7*	HLA-A_ENST00000376806.5_Nonsense_Mutation_p.R7*|HLA-A_ENST00000376809.5_Nonsense_Mutation_p.R7*|HLA-A_ENST00000376802.2_Nonsense_Mutation_p.R7*			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	7					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						CATGGCGCCCCGAACCCTCCT	0.677000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			17	65					0	0	0.006122	0	0
PRR12	57479	broad.mit.edu	37	19	50098966	50098966	+	Silent	SNP	G	G	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:50098966G>T	ENST00000418929.2	+	4	1386	c.1374G>T	c.(1372-1374)ggG>ggT	p.G458G		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	207	Pro-rich.						DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		AGGCCTACGGGCAAGGGTTTG	0.711000													7	20					0.00198382	0.00321251	0.001984	1	0
KANSL1	284058	broad.mit.edu	37	17	44248386	44248386	+	Nonsense_Mutation	SNP	G	G	C	rs142696045	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:44248386G>C	ENST00000262419.6	-	2	1594	c.1124C>G	c.(1123-1125)tCa>tGa	p.S375*	KANSL1_ENST00000575318.1_Nonsense_Mutation_p.S375*|KANSL1_ENST00000574590.1_Nonsense_Mutation_p.S375*|KANSL1_ENST00000572904.1_Nonsense_Mutation_p.S375*|KANSL1_ENST00000432791.1_Nonsense_Mutation_p.S375*|KANSL1_ENST00000393476.3_5'UTR|KANSL1_ENST00000576248.1_5'UTR	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	375						MLL1 complex	protein binding										TTCTGAAATTGAATTGCTTTT	0.453000													23	121					0	0	0.012319	0	0
FAM69B	138311	broad.mit.edu	37	9	139617956	139617956	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:139617956C>T	ENST00000371691.1	+	3	1864	c.765C>T	c.(763-765)taC>taT	p.Y255Y	SNHG7_ENST00000414282.1_RNA|FAM69B_ENST00000371692.4_Silent_p.Y342Y			Q5VUD6	FA69B_HUMAN	family with sequence similarity 69, member B	342						endoplasmic reticulum membrane|integral to membrane				NS(1)|endometrium(3)|large_intestine(2)|lung(1)|prostate(1)	8	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;1.03e-05)|Epithelial(140;0.00013)		ACTGCACCTACGGGCGCGACT	0.687000													8	13					0	0	0.004482	0	0
SLC1A2	6506	broad.mit.edu	37	11	35308446	35308446	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:35308446C>G	ENST00000278379.3	-	8	1426	c.1144G>C	c.(1144-1146)Gat>Cat	p.D382H	SLC1A2_ENST00000395750.1_Missense_Mutation_p.D373H|SLC1A2_ENST00000395753.1_Missense_Mutation_p.D373H|SLC1A2_ENST00000606205.1_Missense_Mutation_p.D382H	NM_004171.3	NP_004162.2	P43004	EAA2_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 2	382					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity	p.D382Y(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|urinary_tract(1)	24	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	ACACGCTTATCAATCCCCAGA	0.458000													39	124					0	0	0.006999	0	0
SH3GL3	6457	broad.mit.edu	37	15	84286874	84286874	+	Silent	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:84286874C>G	ENST00000324537.5	+	12	1395	c.903C>G	c.(901-903)ctC>ctG	p.L301L	SH3GL3_ENST00000564054.1_3'UTR|SH3GL3_ENST00000535412.1_3'UTR|SH3GL3_ENST00000434347.1_Silent_p.L301L|SH3GL3_ENST00000427482.2_Silent_p.L293L			Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	293	SH3.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30						GTCGTGGTCTCTATGACTTTG	0.398000													20	49					0	0	0.008871	0	0
CCDC83	220047	broad.mit.edu	37	11	85597249	85597249	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:85597249G>A	ENST00000280245.4	+	5	862	c.350G>A	c.(349-351)cGc>cAc	p.R117H	CCDC83_ENST00000529676.2_Intron|CCDC83_ENST00000376067.1_Intron|CCDC83_ENST00000342404.3_Missense_Mutation_p.R117H	NM_173556.3	NP_775827.2	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	117								p.R117H(2)|p.R117L(1)		breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|skin(3)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				ACAGATATGCGCATGCAAATA	0.333000													6	15					0	0	0.001984	0	0
FBXL16	146330	broad.mit.edu	37	16	745785	745785	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:745785C>T	ENST00000397621.1	-	3	1103	c.772G>A	c.(772-774)Gac>Aac	p.D258N	FBXL16_ENST00000324361.5_Missense_Mutation_p.D258N|FBXL16_ENST00000562563.1_Missense_Mutation_p.D46N	NM_153350.3	NP_699181.2	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	258										endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)	10		Hepatocellular(780;0.0218)				GCGATGGCGTCGTCGGCCACG	0.687000													20	30					0	0	0.003330	0	0
TBX5	6910	broad.mit.edu	37	12	114804166	114804166	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:114804166G>C	ENST00000310346.4	-	8	1452	c.786C>G	c.(784-786)acC>acG	p.T262T	TBX5_ENST00000526441.1_Silent_p.T262T|TBX5_ENST00000405440.2_Silent_p.T262T|TBX5_ENST00000349716.5_Silent_p.T212T	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	262					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TTTGCCTCACGGTGCTCCTGG	0.512000													4	88					0	0	0.009096	0	0
SLIT1	6585	broad.mit.edu	37	10	98770859	98770859	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:98770859C>T	ENST00000266058.4	-	31	3477	c.3232G>A	c.(3232-3234)Gac>Aac	p.D1078N	SLIT1_ENST00000371070.4_Missense_Mutation_p.D1078N|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1078	EGF-like 4.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		CTGCAGTTGTCACCTGCATAA	0.607000													5	34					0	0	0.000602	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456154	5456154	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:5456154G>A	ENST00000222033.4	+	1	729	c.652G>A	c.(652-654)Gcc>Acc	p.A218T		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	218	PA.					integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GAGCGAGGCCGCCTCGCAGGA	0.672000													34	74					0	0	0.003271	0	0
NOTCH3	4854	broad.mit.edu	37	19	15290215	15290215	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:15290215G>A	ENST00000263388.2	-	21	3495	c.3420C>T	c.(3418-3420)ctC>ctT	p.L1140L		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	1140	EGF-like 29; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			AGCGGGCCACGAGGTCAATGC	0.602000													12	37					0	0	0.001855	0	0
WASL	8976	broad.mit.edu	37	7	123346798	123346798	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:123346798C>T	ENST00000223023.4	-	3	667	c.335G>A	c.(334-336)gGa>gAa	p.G112E		NM_003941.2	NP_003932.3	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome-like	112	WH1.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ACTTACATCTCCAGCAAAGGT	0.284000													18	38					0	0	0.004990	0	0
COL5A2	1290	broad.mit.edu	37	2	189953461	189953461	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:189953461G>C	ENST00000374866.3	-	8	879	c.605C>G	c.(604-606)tCt>tGt	p.S202C		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	202					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCCAAGTCCAGATTTTTCATC	0.353000													18	49					0	0	0.008871	0	0
RBL1	5933	broad.mit.edu	37	20	35695460	35695460	+	Silent	SNP	A	A	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:35695460A>G	ENST00000373664.3	-	5	687	c.621T>C	c.(619-621)gaT>gaC	p.D207D	RBL1_ENST00000344359.3_Silent_p.D207D	NM_002895.2	NP_002886.2	P28749	RBL1_HUMAN	retinoblastoma-like 1 (p107)	207					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			NS(1)|breast(1)|endometrium(7)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	42		Myeloproliferative disorder(115;0.00878)				CAAAAATCAGATCCAAGCAGC	0.303000													25	68					0	0	0.004656	0	0
TCOF1	6949	broad.mit.edu	37	5	149754239	149754239	+	Silent	SNP	C	C	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:149754239C>A	ENST00000451292.1	+	9	1251	c.1143C>A	c.(1141-1143)tcC>tcA	p.S381S	TCOF1_ENST00000513346.1_Silent_p.S381S|TCOF1_ENST00000394269.3_Silent_p.S381S|TCOF1_ENST00000377797.3_Silent_p.S381S|TCOF1_ENST00000504761.2_Silent_p.S381S|TCOF1_ENST00000323668.7_Silent_p.S304S|TCOF1_ENST00000445265.2_Silent_p.S304S|TCOF1_ENST00000439160.2_Silent_p.S381S			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	381					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAAGGAGTCCCCCAGGAAAG	0.657000													20	66					1.2644e-06	2.10176e-06	0.010504	1	0
QKI	9444	broad.mit.edu	37	6	163876442	163876442	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:163876442G>C	ENST00000361752.3	+	2	825	c.274G>C	c.(274-276)Gaa>Caa	p.E92Q	QKI_ENST00000453779.2_Missense_Mutation_p.E92Q|QKI_ENST00000424802.3_Missense_Mutation_p.E92Q|QKI_ENST00000275262.7_Missense_Mutation_p.E92Q|QKI_ENST00000361195.2_Missense_Mutation_p.E92Q|QKI_ENST00000392127.2_Missense_Mutation_p.E92Q	NM_006775.2|NM_206853.2|NM_206854.2|NM_206855.2	NP_006766.1|NP_996735.1|NP_996736.1|NP_996737.1	Q96PU8	QKI_HUMAN	QKI, KH domain containing, RNA binding	92	KH.				mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(5)|ovary(1)|prostate(3)|urinary_tract(2)	27		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		GCCTGTAAAAGAATACCCAGA	0.343000													24	54					0	0	0.003330	0	0
UBE2R2	54926	broad.mit.edu	37	9	33917126	33917126	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:33917126C>G	ENST00000263228.3	+	5	799	c.608C>G	c.(607-609)tCa>tGa	p.S203*		NM_017811.3	NP_060281.2	Q712K3	UB2R2_HUMAN	ubiquitin-conjugating enzyme E2R 2	203	Asp/Glu-rich (acidic).				protein K48-linked ubiquitination|protein monoubiquitination		ATP binding|ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8			LUSC - Lung squamous cell carcinoma(29;0.0176)	GBM - Glioblastoma multiforme(74;0.188)		GACAACAGCTCAGATTTGCTT	0.463000													8	66					0	0	0.004482	0	0
DUSP10	11221	broad.mit.edu	37	1	221913036	221913036	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:221913036G>A	ENST00000366899.3	-	2	289	c.51C>T	c.(49-51)ccC>ccT	p.P17P	DUSP10_ENST00000323825.3_Intron	NM_007207.4	NP_009138.1	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10	17					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			NS(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(131;0.0103)		GAGGTCGGACGGGCCTAGATA	0.517000													33	76					0	0	0.012213	0	0
OR10A2	341276	broad.mit.edu	37	11	6891450	6891450	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:6891450C>T	ENST00000307322.4	+	1	527	c.465C>T	c.(463-465)ttC>ttT	p.F155F		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GTTTTCCATTCTGTGGCACCA	0.537000													33	114					0	0	0.003271	0	0
CCND2	894	broad.mit.edu	37	12	4409145	4409145	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:4409145C>T	ENST00000261254.3	+	5	1109	c.840C>T	c.(838-840)acC>acT	p.T280T		NM_001759.3	NP_001750.1	P30279	CCND2_HUMAN	cyclin D2	280					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			AAGCCAGCACCCCTACAGACG	0.547000			T	IGL@	"""NHL,CLL"""								3	29					0	0	0.004672	0	0
GRIN2B	2904	broad.mit.edu	37	12	13722780	13722780	+	Silent	SNP	C	C	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:13722780C>A	ENST00000279593.3	-	11	2552	c.2343G>T	c.(2341-2343)ctG>ctT	p.L781L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	781					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CAAAGAGCTGCAGGATAGCAA	0.488000													18	46					1.33834e-09	2.26975e-09	0.007413	1	0
MED1	5469	broad.mit.edu	37	17	37576168	37576168	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:37576168G>C	ENST00000300651.6	-	14	1322	c.1099C>G	c.(1099-1101)Ctt>Gtt	p.L367V	MED1_ENST00000394287.3_Missense_Mutation_p.L367V	NM_004774.3	NP_004765.2	Q15648	MED1_HUMAN	mediator complex subunit 1	367	Interaction with ESR1.|Interaction with the Mediator complex and THRA.|Interaction with the Mediator complex.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(1)|breast(2)|cervix(3)|kidney(3)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(7)|urinary_tract(1)	59		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TGACCAGGAAGAGCCTGGGCA	0.433000										HNSCC(31;0.082)			23	36					0	0	0.014323	0	0
ATP2A1	487	broad.mit.edu	37	16	28906160	28906160	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:28906160G>A	ENST00000395503.4	+	12	1489	c.1305G>A	c.(1303-1305)gaG>gaA	p.E435E	ATP2A1_ENST00000357084.3_Silent_p.E435E|ATP2A1_ENST00000536376.1_Silent_p.E310E	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	435					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						GTGTCTATGAGAAGGTCGGCG	0.567000													17	41					0	0	0.004007	0	0
SYNE1	23345	broad.mit.edu	37	6	152706952	152706952	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:152706952C>T	ENST00000367255.5	-	55	9110	c.8509G>A	c.(8509-8511)Gag>Aag	p.E2837K	SYNE1_ENST00000448038.1_Missense_Mutation_p.E2844K|SYNE1_ENST00000341594.5_Missense_Mutation_p.E2876K|SYNE1_ENST00000265368.4_Missense_Mutation_p.E2837K|SYNE1_ENST00000423061.1_Missense_Mutation_p.E2844K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2837					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCACAATCTCTTCCACTTTC	0.408000										HNSCC(10;0.0054)			19	79					0	0	0.008871	0	0
KAZN	23254	broad.mit.edu	37	1	14925658	14925658	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:14925658C>T	ENST00000376030.2	+	1	459	c.165C>T	c.(163-165)agC>agT	p.S55S	KAZN_ENST00000422387.2_Silent_p.S55S|KAZN_ENST00000503743.1_Silent_p.S55S	NM_201628.2	NP_963922.2	Q674X7	KAZRN_HUMAN	kazrin, periplakin interacting protein	55					keratinization	cornified envelope|cytoplasm|desmosome|nucleus				central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(1)|prostate(2)	25						ccgcggccagcgcctcggcgg	0.756000													3	4					0	0	0.004672	0	0
TMEM140	55281	broad.mit.edu	37	7	134849458	134849458	+	Missense_Mutation	SNP	G	G	A	rs143180494	by1000genomes	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:134849458G>A	ENST00000275767.2	+	2	488	c.265G>A	c.(265-267)Ggg>Agg	p.G89R	C7orf49_ENST00000459937.1_Intron	NM_018295.4	NP_060765.4	Q9NV12	TM140_HUMAN	transmembrane protein 140	89						integral to membrane				kidney(1)|large_intestine(2)|lung(2)	5						TGGCGTGTACGGGTCCCTGGT	0.652000													38	69					0	0	0.004878	0	0
S100A2	6273	broad.mit.edu	37	1	153533987	153533987	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:153533987C>T	ENST00000368708.3	-	3	594	c.222G>A	c.(220-222)gaG>gaA	p.E74E	S100A2_ENST00000368707.4_3'UTR|S100A2_ENST00000368709.1_Silent_p.E74E|S100A2_ENST00000368710.1_Silent_p.E74E|S100A2_ENST00000497140.1_Silent_p.E41E|S100A2_ENST00000487430.2_Silent_p.E74E	NM_005978.3	NP_005969.1	P29034	S10A2_HUMAN	S100 calcium binding protein A2	75	EF-hand 2.				endothelial cell migration		calcium ion binding			endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	5	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAACAGCATACTCCTGGAAGT	0.527000													56	149					0	0	0.014410	0	0
IGSF9B	22997	broad.mit.edu	37	11	133792107	133792107	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:133792107G>C	ENST00000321016.8	-	17	2522	c.2292C>G	c.(2290-2292)ctC>ctG	p.L764L	IGSF9B_ENST00000533871.2_Silent_p.L764L			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	764						integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GGGTGATGGAGAGTGGAGGGT	0.602000													4	16					0	0	0.009096	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664186	22664186	+	RNA	SNP	A	A	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr22:22664186A>G	ENST00000426066.1	+	0	709					NR_027293.1																						CAGATCAAGAAAGCACTCTGA	0.498000													3	65					0	0	0.000602	0	0
PDIA2	64714	broad.mit.edu	37	16	335330	335330	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:335330G>A	ENST00000219406.6	+	6	832	c.814G>A	c.(814-816)Gcg>Acg	p.A272T	PDIA2_ENST00000404312.1_Missense_Mutation_p.A269T|PDIA2_ENST00000462950.1_3'UTR	NM_006849.2	NP_006840.2	Q13087	PDIA2_HUMAN	protein disulfide isomerase family A, member 2	272					apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			breast(1)|central_nervous_system(4)|kidney(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	17		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				CAAGATCTTCGCGGCCAGGAT	0.642000													11	40					0	0	0.010729	0	0
ORAI1	84876	broad.mit.edu	37	12	122079382	122079382	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:122079382G>A	ENST00000330079.7	+	2	938	c.745G>A	c.(745-747)Ggc>Agc	p.G249S		NM_032790.3	NP_116179.2	Q96D31	CRCM1_HUMAN	ORAI calcium release-activated calcium modulator 1	247					platelet activation|positive regulation of calcium ion transport	integral to plasma membrane	protein binding|store-operated calcium channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	11	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000415)|Epithelial(86;0.00148)		GGTGCCCTTCGGCCTGATCTT	0.627000													28	56					0	0	0.004656	0	0
ROBO3	64221	broad.mit.edu	37	11	124750348	124750348	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:124750348C>T	ENST00000397801.1	+	27	4185	c.3993C>T	c.(3991-3993)ttC>ttT	p.F1331F	ROBO3_ENST00000525482.1_3'UTR|ROBO3_ENST00000538940.1_Silent_p.F1309F|ROBO3_ENST00000543966.1_Silent_p.F94F	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1331					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GACCAAGCTTCCTGTCCCGGG	0.662000													10	17					0	0	0.008291	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36097115	36097115	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr14:36097115C>T	ENST00000258840.6	-	34	5051	c.4661G>A	c.(4660-4662)cGc>cAc	p.R1554H	RALGAPA1_ENST00000307138.6_Missense_Mutation_p.R1507H|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.R1507H|RALGAPA1_ENST00000382366.3_Missense_Mutation_p.R1520H			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	1507	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AATAACAGTGCGGGCTGCTAT	0.398000													45	35					0	0	0.014410	0	0
FZD2	2535	broad.mit.edu	37	17	42635585	42635585	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:42635585G>A	ENST00000315323.3	+	1	661	c.529G>A	c.(529-531)Ggg>Agg	p.G177R		NM_001466.3	NP_001457.1	Q14332	FZD2_HUMAN	frizzled family receptor 2	177					axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(8)	33		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		gccgggtgccgggggcacccc	0.766000													5	13					0	0	0.001984	0	0
ARGFX	503582	broad.mit.edu	37	3	121303817	121303817	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:121303817G>C	ENST00000334384.3	+	3	284	c.274G>C	c.(274-276)Gag>Cag	p.E92Q		NM_001012659.1	NP_001012677.1	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	92						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(114;0.152)		ACAGTATGAGGAGCTAGAAGC	0.443000													30	116					0	0	0.006320	0	0
CCDC147	159686	broad.mit.edu	37	10	106113661	106113661	+	Silent	SNP	T	T	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:106113661T>A	ENST00000369704.3	+	1	140	c.6T>A	c.(4-6)gcT>gcA	p.A2A	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	2										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		TCAGGATGGCTGAGGTCAGGA	0.597000											OREG0020519	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	32					0	0	0.003954	0	0
RAB13	5872	broad.mit.edu	37	1	153957221	153957221	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:153957221C>T	ENST00000368575.3	-	2	276	c.161G>A	c.(160-162)gGg>gAg	p.G54E	RAB13_ENST00000462680.1_5'UTR	NM_002870.2	NP_002861.1	P51153	RAB13_HUMAN	RAB13, member RAS oncogene family	54					cell adhesion|protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	cytoplasmic vesicle membrane|tight junction	GTP binding|GTPase activity			breast(1)|endometrium(3)|kidney(1)|lung(5)|urinary_tract(1)	11	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GATCTTCTTCCCCTCTATATC	0.448000													4	31					0	0	0.009096	0	0
AGBL1	123624	broad.mit.edu	37	15	86687068	86687068	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:86687068G>A	ENST00000441037.2	+	2	211	c.116G>A	c.(115-117)gGc>gAc	p.G39D	AGBL1_ENST00000421325.2_Missense_Mutation_p.G39D	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	39					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						GCCAAAGTTGGCCTAAGAGGT	0.522000													17	39					0	0	0.004990	0	0
GRM3	2913	broad.mit.edu	37	7	86468769	86468769	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:86468769G>A	ENST00000361669.2	+	4	3038	c.1939G>A	c.(1939-1941)Ggg>Agg	p.G647R	GRM3_ENST00000439827.1_Intron|GRM3_ENST00000546348.1_Missense_Mutation_p.G239R|GRM3_ENST00000394720.2_Intron|GRM3_ENST00000536043.1_Missense_Mutation_p.G519R	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	647					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCGCCGACTCGGGCTGGGGAG	0.527000													53	136					0	0	0.014410	0	0
SYAP1	94056	broad.mit.edu	37	X	16737953	16737953	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chrX:16737953G>C	ENST00000380155.3	+	1	199	c.106G>C	c.(106-108)Gag>Cag	p.E36Q	SYAP1_ENST00000495743.1_3'UTR	NM_032796.3	NP_116185.2	Q96A49	SYAP1_HUMAN	synapse associated protein 1	36										endometrium(3)|lung(4)|pancreas(1)|prostate(1)|skin(1)	10	Hepatocellular(33;0.0997)					GACGGTGGCTGAGTCTGCGGA	0.667000													4	3					0	0	0.009096	0	0
TACC2	10579	broad.mit.edu	37	10	123845099	123845099	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:123845099G>C	ENST00000369005.1	+	4	3424	c.3084G>C	c.(3082-3084)tgG>tgC	p.W1028C	TACC2_ENST00000513429.1_Intron|TACC2_ENST00000334433.3_Missense_Mutation_p.W1028C|TACC2_ENST00000453444.2_Missense_Mutation_p.W1028C|TACC2_ENST00000515273.1_Missense_Mutation_p.W1028C|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515603.1_Missense_Mutation_p.W1028C	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1028						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCCCACTCTGGGGCTTGAGTA	0.562000													12	41					0	0	0.010729	0	0
PGAM5	192111	broad.mit.edu	37	12	133295392	133295392	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:133295392C>G	ENST00000317555.2	+	6	822	c.764C>G	c.(763-765)tCc>tGc	p.S255C	PGAM5_ENST00000498926.2_Intron|PGAM5_ENST00000454808.2_Intron|PXMP2_ENST00000545677.1_Intron|PGAM5_ENST00000543955.1_Intron|PGAM5_ENST00000541034.1_Intron	NM_138575.3	NP_612642.2	Q96HS1	PGAM5_HUMAN	phosphoglycerate mutase family member 5	0						integral to membrane|mitochondrial outer membrane	phosphoprotein phosphatase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	5	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.89e-08)|Epithelial(86;1.14e-07)|all cancers(50;3.57e-06)		CTTCTGGGGTCCTGACCTCTT	0.637000													19	63					0	0	0.008871	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V|FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													5	76					0	0	0.001984	0	0
C2orf44	80304	broad.mit.edu	37	2	24261335	24261335	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:24261335G>A	ENST00000295148.4	-	2	1087	c.1030C>T	c.(1030-1032)Ctg>Ttg	p.L344L	C2orf44_ENST00000406895.3_Silent_p.L344L	NM_025203.2	NP_079479.1	Q9H6R7	CB044_HUMAN	chromosome 2 open reading frame 44	344							protein binding		C2orf44/ALK(2)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AATGCTATCAGATCAGGAACC	0.413000			T	ALK	NSCLC								16	44					0	0	0.003163	0	0
DDX20	11218	broad.mit.edu	37	1	112309065	112309065	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:112309065C>T	ENST00000475700.1	+	3	3201	c.843C>T	c.(841-843)taC>taT	p.Y281Y	DDX20_ENST00000369702.4_Silent_p.Y673Y			Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	673					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			endometrium(3)|kidney(7)|large_intestine(6)|lung(3)|pancreas(1)|prostate(1)	21		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATAAGTCATACTTGGAAGGCT	0.453000													14	43					0	0	0.003163	0	0
MYBPC2	4606	broad.mit.edu	37	19	50958903	50958903	+	Splice_Site	SNP	T	T	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:50958903T>C	ENST00000357701.5	+	20	2389		c.e20+2			NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type						cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		TGGAAGGCTGTGAGTGACCCT	0.602000													31	46					0	0	0.010818	0	0
TANGO6	79613	broad.mit.edu	37	16	69007962	69007962	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:69007962G>C	ENST00000261778.1	+	15	2745	c.2733G>C	c.(2731-2733)gaG>gaC	p.E911D		NM_024562.1	NP_078838.1			transport and golgi organization 6 homolog (Drosophila)																		TCTATCCTGAGAAAATCTTGC	0.458000													11	23					0	0	0.008291	0	0
SEMG1	6406	broad.mit.edu	37	20	43837187	43837187	+	Missense_Mutation	SNP	C	C	A	rs145325570	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:43837187C>A	ENST00000372781.3	+	2	1306	c.1249C>A	c.(1249-1251)Cta>Ata	p.L417I	SEMG1_ENST00000244069.6_Missense_Mutation_p.L357I	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				AGAACAAGACCTACTCAGTCA	0.438000													21	48					4.96729e-08	8.36772e-08	0.008871	1	0
VPS52	6293	broad.mit.edu	37	6	33219368	33219368	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:33219368G>A	ENST00000445902.2	-	19	2170	c.1952C>T	c.(1951-1953)tCa>tTa	p.S651L	VPS52_ENST00000478934.1_5'UTR|HCG25_ENST00000450514.1_RNA|HCG25_ENST00000442228.1_RNA|HCG25_ENST00000427196.1_RNA|HCG25_ENST00000422366.1_RNA|VPS52_ENST00000482399.1_3'UTR|VPS52_ENST00000436044.2_Missense_Mutation_p.S526L	NM_022553.4	NP_072047.4	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52 homolog (S. cerevisiae)	651					protein transport	endosome membrane|Golgi apparatus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(8)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28						TTCCACTGATGATTTCCAGGA	0.507000													30	74					0	0	0.009535	0	0
PTPRC	5788	broad.mit.edu	37	1	198685828	198685828	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:198685828C>G	ENST00000367376.2	+	13	1474	c.1303C>G	c.(1303-1305)Ctg>Gtg	p.L435V	PTPRC_ENST00000352140.3_Missense_Mutation_p.L387V|PTPRC_ENST00000594404.1_Missense_Mutation_p.L274V|PTPRC_ENST00000348564.6_Missense_Mutation_p.L276V|PTPRC_ENST00000442510.2_Missense_Mutation_p.L437V	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	435	Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						TTGCCTCAATCTGGATAAAAA	0.303000													12	54					0	0	0.013537	0	0
NCOA7	135112	broad.mit.edu	37	6	126203622	126203622	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:126203622G>A	ENST00000368357.3	+	8	976	c.624G>A	c.(622-624)tcG>tcA	p.S208S	NCOA7_ENST00000392477.2_Silent_p.S208S|NCOA7_ENST00000229634.9_Silent_p.S104S	NM_001199619.1|NM_001199620.1	NP_001186548.1|NP_001186549.1	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7	208					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(2)	39				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		GAGTCTTATCGTCTACTTCTG	0.348000													7	39					0	0	0.003080	0	0
CLDND1	56650	broad.mit.edu	37	3	98240146	98240146	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:98240146T>G	ENST00000503004.1	-	2	1002	c.123A>C	c.(121-123)gaA>gaC	p.E41D	CLDND1_ENST00000513287.1_Missense_Mutation_p.E41D|CLDND1_ENST00000510545.1_Missense_Mutation_p.E41D|CLDND1_ENST00000507874.1_Missense_Mutation_p.E41D|CLDND1_ENST00000508503.1_5'UTR|CLDND1_ENST00000437922.1_Missense_Mutation_p.E64D|CLDND1_ENST00000502288.1_Intron|CLDND1_ENST00000394180.2_Missense_Mutation_p.E41D|CLDND1_ENST00000394181.2_Missense_Mutation_p.E41D|CLDND1_ENST00000394185.2_Missense_Mutation_p.E41D|CLDND1_ENST00000341181.6_Missense_Mutation_p.E41D|CLDND1_ENST00000511081.1_Intron			Q9NY35	CLDN1_HUMAN	claudin domain containing 1	41						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	9						CACTGGAATTTTCTTGAACTG	0.393000													15	46					0	0	0.004007	0	0
MECOM	2122	broad.mit.edu	37	3	168834351	168834351	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:168834351C>A	ENST00000464456.1	-	7	1945	c.745G>T	c.(745-747)Gga>Tga	p.G249*	MECOM_ENST00000264674.3_Nonsense_Mutation_p.G314*|MECOM_ENST00000433243.2_Nonsense_Mutation_p.G250*|MECOM_ENST00000392736.3_Nonsense_Mutation_p.G249*|MECOM_ENST00000494292.1_Nonsense_Mutation_p.G437*|MECOM_ENST00000460814.1_Nonsense_Mutation_p.G249*|MECOM_ENST00000472280.1_Nonsense_Mutation_p.G250*|MECOM_ENST00000468789.1_Nonsense_Mutation_p.G249*	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						CCAAAAAATCCACCTGCCGCA	0.453000													18	59					1.2644e-06	2.10176e-06	0.010504	1	0
DNTTIP2	30836	broad.mit.edu	37	1	94342345	94342345	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:94342345G>A	ENST00000436063.2	-	2	1203	c.1146C>T	c.(1144-1146)ccC>ccT	p.P382P	DNTTIP2_ENST00000460191.1_5'UTR	NM_014597.4	NP_055412.2	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 2	382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	38		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		TTGCTTTTATGGGGCTCTTTT	0.398000													139	171					0	0	0.014410	0	0
MYNN	55892	broad.mit.edu	37	3	169496734	169496734	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:169496734G>C	ENST00000349841.5	+	3	1108	c.445G>C	c.(445-447)Gat>Cat	p.D149H	MYNN_ENST00000392733.1_Missense_Mutation_p.D149H|MYNN_ENST00000356716.4_Missense_Mutation_p.D149H|RP11-362K14.5_ENST00000602342.1_RNA|MYNN_ENST00000544106.1_Missense_Mutation_p.D149H	NM_018657.4	NP_061127.1	Q9NPC7	MYNN_HUMAN	myoneurin	149						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			TACTCTGCGAGATTATAATAA	0.343000													21	36					0	0	0.008871	0	0
TICRR	90381	broad.mit.edu	37	15	90143870	90143870	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:90143870C>T	ENST00000268138.7	+	9	2212	c.2107C>T	c.(2107-2109)Cga>Tga	p.R703*	TICRR_ENST00000560985.1_Nonsense_Mutation_p.R702*					TOPBP1-interacting checkpoint and replication regulator																		TAAAAGTCTTCGACAGAATCT	0.303000													6	19					0	0	0.003080	0	0
C2orf44	80304	broad.mit.edu	37	2	24261747	24261747	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:24261747G>C	ENST00000295148.4	-	2	675	c.618C>G	c.(616-618)gtC>gtG	p.V206V	C2orf44_ENST00000406895.3_Silent_p.V206V	NM_025203.2	NP_079479.1	Q9H6R7	CB044_HUMAN	chromosome 2 open reading frame 44	206							protein binding		C2orf44/ALK(2)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATGGAGCAGACGTGGCTGT	0.488000			T	ALK	NSCLC								15	47					0	0	0.003163	0	0
CEACAM6	4680	broad.mit.edu	37	19	42260628	42260628	+	Missense_Mutation	SNP	G	G	A	rs145319104		TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:42260628G>A	ENST00000199764.6	+	2	403	c.185G>A	c.(184-186)cGt>cAt	p.R62H	CEA_ENST00000598976.1_Intron	NM_002483.4	NP_002474.3	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	62	Ig-like V-type.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				breast(1)|kidney(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		CCCCAGAATCGTATTGGTTAC	0.512000													6	189					0	0	0.001168	0	0
MS4A2	2206	broad.mit.edu	37	11	59857261	59857261	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:59857261G>A	ENST00000278888.3	+	2	255	c.153G>A	c.(151-153)ctG>ctA	p.L51L		NM_000139.4	NP_000130.1	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member 2	51					cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			endometrium(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)	17		all_epithelial(135;0.245)			Omalizumab(DB00043)	ATACATGGCTGACAGTTTTGA	0.468000													23	44					0	0	0.014323	0	0
ZNF789	285989	broad.mit.edu	37	7	99084583	99084583	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:99084583T>G	ENST00000331410.5	+	5	1020	c.750T>G	c.(748-750)tgT>tgG	p.C250W	ZNF789_ENST00000494186.1_Intron|ZNF789_ENST00000493485.1_Intron	NM_213603.2	NP_998768.2	Q5FWF6	ZN789_HUMAN	zinc finger protein 789	250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)	11	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					ATAAACAGTGTCACCTGCAAA	0.428000													27	67					0	0	0.004656	0	0
EHD4	30844	broad.mit.edu	37	15	42192864	42192864	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:42192864C>A	ENST00000220325.4	-	6	1688	c.1605G>T	c.(1603-1605)aaG>aaT	p.K535N		NM_139265.3	NP_644670.1	Q9H223	EHD4_HUMAN	EH-domain containing 4	535	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(7)|ovary(2)|stomach(1)|urinary_tract(1)	20		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		TGGGCAGGGACTTCCTGTGCG	0.667000													11	10					3.86212e-05	6.3359e-05	0.008291	1	0
SH2B1	25970	broad.mit.edu	37	16	28883683	28883683	+	Silent	SNP	T	T	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:28883683T>G	ENST00000337120.5	+	6	4977	c.1686T>G	c.(1684-1686)ggT>ggG	p.G562G	SH2B1_ENST00000322610.8_Silent_p.G562G|SH2B1_ENST00000545570.1_Silent_p.G252G|SH2B1_ENST00000538342.1_Silent_p.G226G|SH2B1_ENST00000359285.5_Silent_p.G562G|SH2B1_ENST00000395532.4_Silent_p.G562G|SH2B1_ENST00000563674.1_Intron	NM_001145812.1|NM_015503.2	NP_001139284.1|NP_056318.2	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1	562	SH2.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25						CAAGGCGGGGTGAATACGTCC	0.612000													4	60					0	0	0.001168	0	0
GS1-124K5.2	0	broad.mit.edu	37	7	65888988	65888988	+	RNA	DEL	T	T	-			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:65888988delT	ENST00000442578.1	-	0	826																											tttttttttcttttttttttt	0.488													2	4	---	---	---	---					
PODXL	5420	broad.mit.edu	37	7	131241030	131241035	+	In_Frame_Del	DEL	GGCGAC	GGCGAC	-	rs11277659		TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:131241030_131241035delGGCGAC	ENST00000541194.1	-	1	341_346	c.84_89delGTCGCC	c.(82-90)ccc>cc	p.PSP28del	PODXL_ENST00000465001.1_Intron|PODXL_ENST00000537928.1_In_Frame_Del_p.PSP28del|PODXL_ENST00000322985.9_In_Frame_Del_p.PSP28del|PODXL_ENST00000378555.3_In_Frame_Del_p.PSP28del	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	28					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle		p.P30_S31delPS(2)		NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					ATTCTGGGAGggcgacggcgacggcg	0.748													3	4	---	---	---	---					
MBD6	114785	broad.mit.edu	37	12	57920934	57920934	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:57920934delC	ENST00000355673.3	+	7	2362	c.2006delC	c.(2005-2007)gcfs	p.A669fs	MBD6_ENST00000431731.2_Frame_Shift_Del_p.A669fs	NM_052897.3	NP_443129.3	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	669	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|urinary_tract(1)	31						CCACTTTCAGCCCCCCCTACC	0.642													14	29	---	---	---	---					
CTRB2	440387	broad.mit.edu	37	16	75238201	75238201	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:75238201delA	ENST00000303037.8	-	7	693	c.650delT	c.(649-651)cgfs	p.L217fs		NM_001025200.3	NP_001020371.3	Q6GPI1	CTRB2_HUMAN	chymotrypsinogen B2	217	Peptidase S1.				digestion|proteolysis	extracellular space	serine-type endopeptidase activity			endometrium(1)|large_intestine(1)|lung(2)	4						CTGGCAGACCAGGGGGCCTCC	0.657													18	49	---	---	---	---					
SREBF1	6720	broad.mit.edu	37	17	17720296	17720297	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:17720296_17720297insTT	ENST00000355815.4	-	10	2019_2020	c.1850_1851insAA	c.(1849-1851)acafs	p.T617fs	SREBF1_ENST00000395757.1_Frame_Shift_Ins_p.T333fs|SREBF1_ENST00000338854.5_Frame_Shift_Ins_p.T587fs|SREBF1_ENST00000261646.5_Frame_Shift_Ins_p.T587fs	NM_001005291.2	NP_001005291.1	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription factor 1	587					cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	14						GGTCAGCCTGCTTGCGATGCCT	0.653													37	100	---	---	---	---					
RSAD1	55316	broad.mit.edu	37	17	48556334	48556334	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:48556334delC	ENST00000258955.2	+	1	174	c.89delC	c.(88-90)tcfs	p.S30fs		NM_018346.1	NP_060816.1	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing 1	30					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GCAGGAGGGTCCCCGAGTCCT	0.776											OREG0024566	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
ZNF831	128611	broad.mit.edu	37	20	57768086	57768086	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:57768086delT	ENST00000371030.2	+	1	2012	c.2012delT	c.(2011-2013)gcfs	p.V671fs		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	671						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					TCAGGCACAGTCCCCACCCAA	0.622													19	35	---	---	---	---					
