Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	26					0	0	6.4e-05	0	0
ECE2	9718	broad.mit.edu	37	3	184009925	184009925	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr3:184009925C>T	ENST00000402825.3	+	19	2551	c.2551C>T	c.(2551-2553)Cgc>Tgc	p.R851C	ECE2_ENST00000357474.5_Missense_Mutation_p.R779C|EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000359140.4_Missense_Mutation_p.R704C|ECE2_ENST00000404464.3_Missense_Mutation_p.R733C	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	851	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity	p.R779C(1)|p.R704C(1)|p.R851C(1)		breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCCCGCTTCCGCGTGCTGGG	0.677000													8	61					0	0	0.000157383	0	0
OR14I1	401994	broad.mit.edu	37	1	248844912	248844912	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr1:248844912G>A	ENST00000342623.3	-	1	717	c.694C>T	c.(694-696)Cga>Tga	p.R232*		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						GCTTTTGCTCGACTCTGTCCT	0.493000													5	78					0	0	0.000602214	0	0
RANBP2	5903	broad.mit.edu	37	2	109352601	109352601	+	Silent	SNP	T	T	C			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr2:109352601T>C	ENST00000283195.6	+	6	804	c.678T>C	c.(676-678)agT>agC	p.S226S		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	226					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						CTGATAAAAGTGACTGGCGAG	0.368000													7	269					0	0	8.12818e-05	0	0
EPPK1	83481	broad.mit.edu	37	8	144946714	144946714	+	Silent	SNP	G	G	A			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr8:144946714G>A	ENST00000525985.1	-	2	779	c.708C>T	c.(706-708)cgC>cgT	p.R236R				P58107	EPIPL_HUMAN	epiplakin 1	236						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGCCCATGGAGCGGAAGGTGA	0.682000													3	15					0	0	6.4e-05	0	0
RANGAP1	5905	broad.mit.edu	37	22	41652800	41652800	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr22:41652800A>C	ENST00000455915.2	-	7	2272	c.803T>G	c.(802-804)gTg>gGg	p.V268G	RANGAP1_ENST00000405486.1_Missense_Mutation_p.V268G|RANGAP1_ENST00000407260.4_Missense_Mutation_p.V213G|RANGAP1_ENST00000356244.3_Missense_Mutation_p.V268G			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	268					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity	p.V268G(3)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						AAAATTAATCACCTCCACCTG	0.637000													5	21					0	0	0.000308642	0	0
ANK3	288	broad.mit.edu	37	10	61835630	61835630	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr10:61835630A>G	ENST00000280772.1	-	37	5200	c.5009T>C	c.(5008-5010)cTa>cCa	p.L1670P	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1670	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGAAGATATTAGCGGTGCTGC	0.388000													3	84					0	0	6.4e-05	0	0
TEX15	56154	broad.mit.edu	37	8	30701885	30701885	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr8:30701885T>A	ENST00000256246.2	-	1	4723	c.4649A>T	c.(4648-4650)gAc>gTc	p.D1550V		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1550										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGACTGCGAGTCTTTACTAAC	0.383000													8	126					0	0	0.000157383	0	0
ATAD5	79915	broad.mit.edu	37	17	29162940	29162940	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr17:29162940C>G	ENST00000321990.4	+	2	2219	c.1841C>G	c.(1840-1842)tCt>tGt	p.S614C	CTD-2349P21.11_ENST00000580873.1_RNA	NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	614					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GGTATTGATTCTGACGATGTA	0.393000													6	64					0	0	0.00116845	0	0
HCAR3	8843	broad.mit.edu	37	12	123200861	123200861	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr12:123200861A>G	ENST00000528880.2	-	1	578	c.424T>C	c.(424-426)Tgg>Cgg	p.W142R	HCAR1_ENST00000356987.2_Intron	NM_006018.2	NP_006009.2	P49019	HCAR3_HUMAN	hydroxycarboxylic acid receptor 3	142						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	9					Mepenzolate(DB04843)|Niacin(DB00627)	GCTGCTGTCCAATTGGAGATC	0.542000													3	77					0	0	0.00024832	0	0
RRBP1	6238	broad.mit.edu	37	20	17639486	17639486	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr20:17639486T>C	ENST00000377813.1	-	3	1970	c.1667A>G	c.(1666-1668)cAg>cGg	p.Q556R	RRBP1_ENST00000246043.4_Missense_Mutation_p.Q556R|RRBP1_ENST00000455029.2_Intron|RRBP1_ENST00000377807.2_Intron|RRBP1_ENST00000360807.4_Intron			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	556	41 X 10 AA approximate tandem repeats of [TN]-Q-[GSA]-[KRQT]-K-[ATGSV]-[ED]- [GTAS]-[ATIS]-[PQTAS].				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						CTTTGTGCCCTGATTAGCAAC	0.522000													3	139					0	0	0.00024832	0	0
SERPING1	710	broad.mit.edu	37	11	57382046	57382046	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr11:57382046A>G	ENST00000403558.1	+	7	1990	c.1624A>G	c.(1624-1626)Agg>Ggg	p.R542G	SERPING1_ENST00000378324.2_Missense_Mutation_p.R447G|SERPING1_ENST00000278407.4_Missense_Mutation_p.R499G|SERPING1_ENST00000378323.4_Missense_Mutation_p.R504G|SERPING1_ENST00000340687.6_Missense_Mutation_p.R462G	NM_001032295.1	NP_001027466.1	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	499					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(1)	27						ATATGACCCCAGGGCCTGAGA	0.622000													3	31					0	0	6.4e-05	0	0
PTPRT	11122	broad.mit.edu	37	20	40727119	40727119	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr20:40727119A>G	ENST00000373198.3	-	28	4089	c.3854T>C	c.(3853-3855)cTg>cCg	p.L1285P	PTPRT_ENST00000373184.1_Missense_Mutation_p.L1273P|PTPRT_ENST00000373190.1_Missense_Mutation_p.L1262P|PTPRT_ENST00000373193.3_Missense_Mutation_p.L1266P|PTPRT_ENST00000356100.2_Missense_Mutation_p.L1272P|PTPRT_ENST00000373187.1_Missense_Mutation_p.L1263P|PTPRT_ENST00000373201.1_Missense_Mutation_p.L1253P	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1263	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATCGAACACCAGCCTCCAGAA	0.592000													3	67					0	0	6.4e-05	0	0
MORC4	79710	broad.mit.edu	37	X	106186359	106186359	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chrX:106186359G>C	ENST00000355610.4	-	15	2036	c.1762C>G	c.(1762-1764)Cta>Gta	p.L588V	MORC4_ENST00000535534.1_Missense_Mutation_p.L336V|MORC4_ENST00000255495.7_Missense_Mutation_p.L588V	NM_001085354.2|NM_024657.4	NP_001078823.1|NP_078933.3	Q8TE76	MORC4_HUMAN	MORC family CW-type zinc finger 4	588							ATP binding|zinc ion binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	28						GAATAATCTAGAGAAGGTGTT	0.453000													8	154					0	0	0.000274275	0	0
SEC22B	9554	broad.mit.edu	37	1	145109975	145109976	+	RNA	INS	-	-	C	rs67257307		TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr1:145109975_145109976insC	ENST00000453618.1	+	0	673							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										CAGGAACTTTGCTAAAGATCTA	0.386													3	3	---	---	---	---					
C8orf58	541565	broad.mit.edu	37	8	22459568	22459570	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr8:22459568_22459570delGCT	ENST00000409586.3	+	4	861_863	c.741_743delGCT	c.(739-744)gag>ga	p.EL247del	C8orf58_ENST00000289989.5_In_Frame_Del_p.EL247del	NM_001013842.2|NM_001198827.1|NM_173686.2	NP_001013864.1|NP_001185756.1|NP_775957.2	Q8NAV2	CH058_HUMAN	chromosome 8 open reading frame 58	247										endometrium(1)|lung(1)|ovary(1)|skin(1)	4		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00563)|Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GGCCATGGGAGCTGCTAAGCCAG	0.640													6	5	---	---	---	---					
HNRNPKP3	399881	broad.mit.edu	37	11	43283606	43283606	+	RNA	DEL	A	A	-			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr11:43283606delA	ENST00000511537.1	-	0	1329					NR_033868.1																						AAGCAAATGTAAAAAAAAAAA	0.388													2	4	---	---	---	---					
