Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr17:39183145A>G	ENST00000361883.5	-	1	309	c.263T>C	c.(262-264)aTc>aCc	p.I88T		NM_031957.1	NP_114163.1	Q9BYS1	KRA15_HUMAN	keratin associated protein 1-5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament		p.I88T(11)		central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	17		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632000													7	56					0	0	0.080935	0	0
RUNX2	860	broad.mit.edu	37	6	45390482	45390482	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr6:45390482C>G	ENST00000371438.1	+	2	569	c.211C>G	c.(211-213)Cag>Gag	p.Q71E	RUNX2_ENST00000371432.3_Missense_Mutation_p.Q57E|RUNX2_ENST00000359524.5_Missense_Mutation_p.Q57E|RUNX2_ENST00000576263.1_Missense_Mutation_p.Q71E|RUNX2_ENST00000541979.1_Missense_Mutation_p.Q139E|RUNX2_ENST00000465038.2_Missense_Mutation_p.Q71E|RUNX2_ENST00000371436.6_Missense_Mutation_p.Q71E|RUNX2_ENST00000352853.5_Missense_Mutation_p.Q139E	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	71	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						gcagcagcagcaggaggcggc	0.716000													3	26					0	0	0.004672	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													5	43					0	0	0.029380	0	0
CUEDC1	404093	broad.mit.edu	37	17	55957076	55957076	+	Silent	SNP	A	A	G			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr17:55957076A>G	ENST00000577830.1	-	3	773	c.360T>C	c.(358-360)ccT>ccC	p.P120P	CUEDC1_ENST00000360238.2_Silent_p.P120P|CUEDC1_ENST00000407144.2_Silent_p.P120P|CUEDC1_ENST00000577840.1_5'UTR	NM_001271875.1	NP_001258804.1	Q9NWM3	CUED1_HUMAN	CUE domain containing 1	120	Pro-rich.									endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12						CCGAGCTATCAGGTTCCAAAG	0.502000													3	99					0	0	0.004672	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659764	24659764	+	RNA	SNP	C	C	G	rs143464834	by1000genomes	TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr22:24659764C>G	ENST00000414583.2	+	0	3289					NR_003714.1																						AGTGTCCTAACAGCCCTGCTT	0.627000													3	15					0	0	0.009096	0	0
AKAP11	11215	broad.mit.edu	37	13	42874583	42874583	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr13:42874583A>C	ENST00000025301.2	+	8	1876	c.1701A>C	c.(1699-1701)aaA>aaC	p.K567N		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	567					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GTGCATTTAAAGACTTACAGA	0.323000													3	59					0	0	0.009096	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								4	66					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7579566	7579566	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr17:7579566delC	ENST00000420246.2	-	4	253	c.121delG	c.(121-123)atfs	p.D42fs	TP53_ENST00000413465.2_Frame_Shift_Del_p.D42fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.D42fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.D42fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.D42fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.D42fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	42	Interaction with HRMT1L2.|Transcription activation (acidic).		D -> Y (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.D41fs*3(1)|p.S37fs*79(1)|p.P13fs*18(1)|p.S33fs*23(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCAAATCATCCATTGCTTGG	0.602		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	285	---	---	---	---					
SOCS7	30837	broad.mit.edu	37	17	36508663	36508665	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr17:36508663_36508665delAGC	ENST00000577233.1	+	1	536_538	c.536_538delAGC	c.(535-540)gag>g	p.EQ179del	SOCS7_ENST00000331159.5_In_Frame_Del_p.EQ179del	NM_014598.2	NP_055413.1	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	179	Mediates interaction with SORBS3.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding	p.Q187delQ(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|prostate(1)|skin(5)	9	Breast(7;3.47e-17)					AGTAGAGGGGagcagcagcagca	0.709													3	6	---	---	---	---					
KCNG2	26251	broad.mit.edu	37	18	77623691	77623692	+	In_Frame_Ins	INS	-	-	GGC	rs71338073		TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr18:77623691_77623692insGGC	ENST00000316249.3	+	1	24_25	c.24_25insGGC	c.(22-27)ccgcgg>ccGGCgcgg	p.8_9PR>PAR		NM_012283.1	NP_036415.1	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G, member 2	8					energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity	p.P8_G9insG(2)		breast(2)|endometrium(4)|lung(7)|skin(1)|upper_aerodigestive_tract(4)	18		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CCTGCTccccgggcggcggcgg	0.772													3	4	---	---	---	---					
CEACAM20	125931	broad.mit.edu	37	19	45017504	45017504	+	RNA	DEL	T	T	-	rs71171252		TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr19:45017504delT	ENST00000454753.1	-	0	1588							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				ttggttttgcttttttttttt	0.458													2	4	---	---	---	---					
