Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DOCK10	55619	broad.mit.edu	37	2	225639746	225639746	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:225639746G>T	ENST00000409592.3	-	52	5984	c.5871C>A	c.(5869-5871)gaC>gaA	p.D1957E	DOCK10_ENST00000258390.7_Missense_Mutation_p.D1963E			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1963	DHR-2.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTGTCTTCCGGTCTTCGATTT	0.507000													7	14					8.12818e-05	0.000136171	0.001984	1	0
SLC17A6	57084	broad.mit.edu	37	11	22364872	22364872	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:22364872T>G	ENST00000263160.3	+	3	856	c.419T>G	c.(418-420)aTt>aGt	p.I140S		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	140					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						ATCACTCAGATTCCGGGAGGC	0.577000													28	65					0	0	0.005443	0	0
KRT34	3885	broad.mit.edu	37	17	39535393	39535393	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:39535393C>A	ENST00000394001.1	-	6	1068	c.1038G>T	c.(1036-1038)gaG>gaT	p.E346D		NM_021013.3	NP_066293.2	O76011	KRT34_HUMAN	keratin 34	346	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Breast(137;0.000496)				TGTAGTGGGCCTCGCTCTCCG	0.577000													39	65					3.66082e-28	9.12703e-28	0.005524	1	0
SLC35F5	80255	broad.mit.edu	37	2	114503857	114503857	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:114503857A>T	ENST00000245680.2	-	5	890	c.477T>A	c.(475-477)tcT>tcA	p.S159S	SLC35F5_ENST00000409342.1_Silent_p.S153S	NM_025181.2	NP_079457.2	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	159					transport	integral to membrane				endometrium(1)|kidney(4)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)	20						CACTTACCAAAGAACTATTCA	0.378000													16	39					0	0	0.003163	0	0
MDM2	4193	broad.mit.edu	37	12	69203025	69203025	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:69203025G>C	ENST00000462284.1	+	2	354	c.52G>C	c.(52-54)Ggt>Cgt	p.G18R	MDM2_ENST00000540827.1_Missense_Mutation_p.G12R|MDM2_ENST00000356290.4_Missense_Mutation_p.G12R|MDM2_ENST00000393413.3_Missense_Mutation_p.G12R|MDM2_ENST00000393410.1_Missense_Mutation_p.G12R|MDM2_ENST00000258148.7_Missense_Mutation_p.G18R|MDM2_ENST00000478070.1_Missense_Mutation_p.G7R|MDM2_ENST00000517852.1_Missense_Mutation_p.G12R|MDM2_ENST00000428863.2_Missense_Mutation_p.G12R|MDM2_ENST00000348801.2_Missense_Mutation_p.G7R|MDM2_ENST00000544561.1_Missense_Mutation_p.G12R|MDM2_ENST00000299252.4_Missense_Mutation_p.G12R|MDM2_ENST00000350057.5_Missense_Mutation_p.G12R|MDM2_ENST00000545204.1_Missense_Mutation_p.G12R|MDM2_ENST00000258149.5_Missense_Mutation_p.G12R|MDM2_ENST00000393412.3_Missense_Mutation_p.G12R|MDM2_ENST00000360430.2_Missense_Mutation_p.G12R	NM_002392.4	NP_002383.2	Q00987	MDM2_HUMAN	MDM2 oncogene, E3 ubiquitin protein ligase	12	Necessary for interaction with USP2.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(8)|prostate(1)|urinary_tract(1)	19	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			ACCTACTGATGGTGCTGTAAC	0.368000			A		"""sarcoma, glioma, colorectal, other"""								134	285					0	0	0.003610	0	0
IQCJ-SCHIP1	100505385	broad.mit.edu	37	3	159583964	159583964	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:159583964G>A	ENST00000337808.6	+	3	1349	c.772G>A	c.(772-774)Gag>Aag	p.E258K	IQCJ-SCHIP1_ENST00000527095.1_Missense_Mutation_p.E26K|SCHIP1_ENST00000445224.2_Missense_Mutation_p.E15K|IQCJ-SCHIP1_ENST00000412423.2_Missense_Mutation_p.E245K|IQCJ-SCHIP1_ENST00000476809.1_Missense_Mutation_p.E307K|IQCJ-SCHIP1_ENST00000460298.1_Missense_Mutation_p.E218K|SCHIP1_ENST00000482804.1_Missense_Mutation_p.E31K|IQCJ-SCHIP1_ENST00000485419.1_Missense_Mutation_p.E334K	NM_001197107.1|NM_014575.3	NP_001184036.1|NP_055390.1	Q9P0W5	SCHI1_HUMAN		258						cytoplasm	identical protein binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						ACAGAAAAATGAGAGAGAGTC	0.403000													27	141					0	0	0.003954	0	0
ADCY8	114	broad.mit.edu	37	8	131861992	131861992	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:131861992G>C	ENST00000286355.5	-	10	4360	c.2268C>G	c.(2266-2268)gtC>gtG	p.V756V	ADCY8_ENST00000377928.3_Intron	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	756					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TGGTGATGAGGACCAGAGCCG	0.473000										HNSCC(32;0.087)			3	11					0	0	0.004672	0	0
CCDC129	223075	broad.mit.edu	37	7	31682573	31682573	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:31682573G>A	ENST00000319386.3	+	11	2138	c.1145G>A	c.(1144-1146)aGg>aAg	p.R382K	CCDC129_ENST00000409210.1_Missense_Mutation_p.R438K|CCDC129_ENST00000451887.2_Missense_Mutation_p.R556K|CCDC129_ENST00000407970.3_Missense_Mutation_p.R530K			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	530										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						ACCACCACGAGGGGAGAATGC	0.547000													56	125					0	0	0.003610	0	0
GRIA2	2891	broad.mit.edu	37	4	158256999	158256999	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:158256999G>T	ENST00000296526.7	+	10	1768	c.1443G>T	c.(1441-1443)tgG>tgT	p.W481C	GRIA2_ENST00000449365.1_Missense_Mutation_p.W434C|GRIA2_ENST00000507898.1_Missense_Mutation_p.W434C|GRIA2_ENST00000264426.9_Missense_Mutation_p.W481C|GRIA2_ENST00000393815.2_Missense_Mutation_p.W434C	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	481					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CGAAAATTTGGAATGGGATGG	0.433000													5	11					1.024e-07	1.8803e-07	0.000602	1	0
OR14A16	284532	broad.mit.edu	37	1	247978277	247978277	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247978277C>T	ENST00000357627.1	-	1	754	c.755G>A	c.(754-756)gGa>gAa	p.G252E		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	252					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						AGCAATGAATCCAGTGGAAAG	0.433000													18	22					0	0	0.000958	0	0
TTN	7273	broad.mit.edu	37	2	179392225	179392225	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:179392225A>G	ENST00000589042.1	-	362	107852	c.107628T>C	c.(107626-107628)aaT>aaC	p.N35876N	TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000587568.1_RNA|TTN_ENST00000342175.6_Silent_p.N27003N|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000359218.5_Silent_p.N26936N|TTN-AS1_ENST00000442329.2_RNA|TTN_ENST00000591111.1_Silent_p.N34235N|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Silent_p.N26811N|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN_ENST00000342992.6_Silent_p.N33308N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	34235							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTGTGTCATATTAGATATTC	0.403000													38	56					0	0	0.005524	0	0
IL13	3596	broad.mit.edu	37	5	131993925	131993925	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:131993925C>A	ENST00000304506.3	+	1	61	c.47C>A	c.(46-48)gCg>gAg	p.A16E	AC004041.2_ENST00000435042.1_RNA|IL13_ENST00000468334.1_Intron	NM_002188.2	NP_002179.2	P35225	IL13_HUMAN	interleukin 13	16					cellular component movement|immune response|inflammatory response|signal transduction	extracellular space|soluble fraction	cytokine activity			large_intestine(1)|lung(1)|ovary(1)|skin(3)	6		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGCCTCATGGCGCTTTTGTTG	0.592000											OREG0003464	type=REGULATORY REGION|Gene=IL13|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	18	51					5.03518e-11	9.98578e-11	0.000958	1	0
ADAM17	6868	broad.mit.edu	37	2	9666299	9666299	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:9666299C>G	ENST00000310823.3	-	6	876	c.694G>C	c.(694-696)Gat>Cat	p.D232H	ADAM17_ENST00000497134.1_Missense_Mutation_p.D232H	NM_003183.4	NP_003174.3	P78536	ADA17_HUMAN	ADAM metallopeptidase domain 17	232	Peptidase M12B.				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			breast(1)|cervix(4)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	28	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		AAGCGATGATCTGCTACCACC	0.358000													35	92					0	0	0.003755	0	0
FPGT	8790	broad.mit.edu	37	1	74670412	74670412	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:74670412C>G	ENST00000370898.2	+	4	718	c.681C>G	c.(679-681)ttC>ttG	p.F227L	FPGT_ENST00000524915.1_Intron|FPGT-TNNI3K_ENST00000557284.1_Intron|FPGT_ENST00000370894.4_Intron|FPGT_ENST00000534056.1_Intron|FPGT-TNNI3K_ENST00000370899.3_Intron|TNNI3K_ENST00000370893.1_Intron|TNNI3K_ENST00000370891.2_Intron|FPGT-TNNI3K_ENST00000370895.1_Intron	NM_001199328.1|NM_003838.3	NP_001186257.1|NP_003829.2			fucose-1-phosphate guanylyltransferase											breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	39						GCCATCGTTTCCTTCATAAGC	0.403000													15	47					0	0	0.003163	0	0
SNX14	57231	broad.mit.edu	37	6	86223949	86223949	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:86223949C>A	ENST00000314673.3	-	25	2572	c.2396G>T	c.(2395-2397)cGg>cTg	p.R799L	SNX14_ENST00000346348.3_Missense_Mutation_p.R746L|SNX14_ENST00000369627.2_Missense_Mutation_p.R790L|SNX14_ENST00000505648.1_Missense_Mutation_p.R747L|SNX14_ENST00000513865.1_Missense_Mutation_p.R518L|SNX14_ENST00000508980.1_5'UTR	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	799					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		GAAAACTACCCGTCCTGAGAA	0.378000													24	50					3.5997e-14	7.62893e-14	0.002299	1	0
CYP2B6	1555	broad.mit.edu	37	19	41516003	41516003	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:41516003C>T	ENST00000324071.4	+	6	934	c.927C>T	c.(925-927)taC>taT	p.Y309Y	CYP2B6_ENST00000593831.1_Intron|CYP2B6_ENST00000330446.5_Intron	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	309					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CTCTCCGCTACGGCTTCCTGC	0.562000													14	68					0	0	0.003163	0	0
SERPINA5	5104	broad.mit.edu	37	14	95058512	95058512	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95058512G>T	ENST00000329597.7	+	6	1367	c.1157G>T	c.(1156-1158)aGg>aTg	p.R386M	SERPINA3_ENST00000553947.1_Intron|SERPINA5_ENST00000553780.1_Missense_Mutation_p.R386M|SERPINA5_ENST00000554276.1_Missense_Mutation_p.R386M|SERPINA5_ENST00000554866.1_Missense_Mutation_p.R386M	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	386					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	GTGTTCAACAGGCCCTTTCTG	0.557000													135	323					8.32301e-65	2.16097e-64	0.003610	1	0
CSMD2	114784	broad.mit.edu	37	1	34180246	34180246	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:34180246C>A	ENST00000373381.4	-	21	3523	c.3347G>T	c.(3346-3348)cGc>cTc	p.R1116L		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1076	CUB 7.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCACGTGATGCGGGCGGTGCC	0.627000													158	105					2.63717e-51	6.80307e-51	0.003610	1	0
PLCL1	5334	broad.mit.edu	37	2	198950550	198950550	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:198950550A>T	ENST00000428675.1	+	2	2707	c.2309A>T	c.(2308-2310)cAg>cTg	p.Q770L	PLCL1_ENST00000437704.2_Missense_Mutation_p.Q672L	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	770	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	AAAACTGTACAGCAAAACAGT	0.408000													20	37					0	0	0.001216	0	0
YME1L1	10730	broad.mit.edu	37	10	27403474	27403474	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:27403474T>C	ENST00000326799.3	-	19	2302	c.2154A>G	c.(2152-2154)gaA>gaG	p.E718E	YME1L1_ENST00000376016.3_Silent_p.E661E|YME1L1_ENST00000375972.3_Silent_p.E628E	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	718					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						TTATTTCTTGTTCGATGGCAG	0.328000													12	43					0	0	0.000978	0	0
SMEK1	55671	broad.mit.edu	37	14	91948115	91948115	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:91948115T>A	ENST00000554684.1	-	4	1216	c.720A>T	c.(718-720)ctA>ctT	p.L240L	SMEK1_ENST00000555462.1_Intron|SMEK1_ENST00000337238.4_Silent_p.L240L|SMEK1_ENST00000428424.2_Intron|SMEK1_ENST00000554943.1_Silent_p.L240L			Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1 (Dictyostelium)	240						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|liver(1)|lung(1)|stomach(1)	6		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		CTGTTTTTGTTAGAAATTCCC	0.338000													20	54					0	0	0.001523	0	0
URB2	9816	broad.mit.edu	37	1	229794961	229794961	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:229794961A>G	ENST00000258243.2	+	10	4628	c.4492A>G	c.(4492-4494)Aga>Gga	p.R1498G		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	1498						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						GCCGGGAATGAGAGACATCTT	0.507000													43	140					0	0	0.002852	0	0
ELOVL3	83401	broad.mit.edu	37	10	103988898	103988898	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:103988898A>G	ENST00000370005.3	+	4	923	c.702A>G	c.(700-702)gaA>gaG	p.E234E		NM_152310.1	NP_689523.1	Q9HB03	ELOV3_HUMAN	ELOVL fatty acid elongase 3	234					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			breast(2)|lung(10)|ovary(2)|prostate(1)|skin(1)	16		Colorectal(252;0.207)		Epithelial(162;4.47e-08)|all cancers(201;7.96e-07)		CCACGATGGAACACTTATTCT	0.498000													15	37					0	0	0.002450	0	0
CDH17	1015	broad.mit.edu	37	8	95161033	95161033	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:95161033C>T	ENST00000027335.3	-	14	1990	c.1866G>A	c.(1864-1866)gtG>gtA	p.V622V	CDH17_ENST00000450165.2_Silent_p.V622V|CDH17_ENST00000441892.2_Silent_p.V408V	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	622	Cadherin 6.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CCAATGGAGCCACACTAAAGA	0.418000													8	19					0	0	0.003080	0	0
ZNF704	619279	broad.mit.edu	37	8	81599465	81599465	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:81599465C>G	ENST00000327835.3	-	4	785	c.554G>C	c.(553-555)aGa>aCa	p.R185T	ZNF704_ENST00000520336.1_5'UTR	NM_001033723.2	NP_001028895.1	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	185						intracellular	zinc ion binding			lung(9)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			ACCAACCTTTCTTTTCCTGGG	0.597000											OREG0018841	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	60					0	0	0.001216	0	0
MFSD9	84804	broad.mit.edu	37	2	103353142	103353142	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:103353142C>G	ENST00000258436.5	-	1	171	c.128G>C	c.(127-129)cGc>cCc	p.R43P		NM_032718.3	NP_116107.3	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing 9	43					transmembrane transport	integral to membrane|plasma membrane	transporter activity			breast(3)|large_intestine(7)|liver(1)|lung(6)|ovary(2)|skin(1)	20						CAGGAAGCGGCGGGCTCCGAC	0.672000													14	42					0	0	0.002450	0	0
RYR2	6262	broad.mit.edu	37	1	237947191	237947191	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:237947191A>C	ENST00000366574.2	+	90	12496	c.12179A>C	c.(12178-12180)cAg>cCg	p.Q4060P	RYR2_ENST00000360064.6_Missense_Mutation_p.Q4066P|RYR2_ENST00000542537.1_Missense_Mutation_p.Q4044P	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4060					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CACTACACGCAGTCAGAAACG	0.483000													12	14					0	0	0.000978	0	0
PPP2R2B	5521	broad.mit.edu	37	5	145969694	145969694	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:145969694T>A	ENST00000394413.3	-	9	1718	c.1148A>T	c.(1147-1149)aAg>aTg	p.K383M	PPP2R2B_ENST00000508545.2_Missense_Mutation_p.K372M|PPP2R2B_ENST00000394410.2_Missense_Mutation_p.K372M|CTB-99A3.1_ENST00000512730.1_RNA|PPP2R2B_ENST00000394414.1_Missense_Mutation_p.K449M|PPP2R2B_ENST00000453001.1_Missense_Mutation_p.K383M|PPP2R2B_ENST00000336640.6_Missense_Mutation_p.K386M|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000394409.3_Missense_Mutation_p.K441M|PPP2R2B_ENST00000356826.3_Missense_Mutation_p.K383M|PPP2R2B_ENST00000504198.1_Missense_Mutation_p.K389M|PPP2R2B_ENST00000394411.4_Missense_Mutation_p.K383M			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	383					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCCCGGGGCTTGCTGTTTTC	0.507000													38	82					0	0	0.005524	0	0
IL12B	3593	broad.mit.edu	37	5	158753716	158753716	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:158753716T>G	ENST00000231228.2	-	2	530	c.75A>C	c.(73-75)gaA>gaC	p.E25D		NM_002187.2	NP_002178.2	P29460	IL12B_HUMAN	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	25	Ig-like C2-type.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity			cervix(1)|endometrium(1)|large_intestine(5)|lung(4)	11	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTTCTTCAGTTCCCATATGG	0.502000													33	77					0	0	0.003271	0	0
FBLN7	129804	broad.mit.edu	37	2	112945094	112945094	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:112945094G>A	ENST00000409903.1	+	8	1308	c.1078G>A	c.(1078-1080)Ggg>Agg	p.G360R	FBLN7_ENST00000331203.2_3'UTR|FBLN7_ENST00000409450.3_3'UTR|FBLN7_ENST00000409667.3_3'UTR			Q53RD9	FBLN7_HUMAN	fibulin 7	0					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						GGGTACACAGGGGCACTGGGG	0.607000													39	111					0	0	0.002522	0	0
OTOP1	133060	broad.mit.edu	37	4	4199579	4199579	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:4199579C>T	ENST00000296358.4	-	5	1006	c.982G>A	c.(982-984)Gtg>Atg	p.V328M		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	328					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACCACCACCACAGCAATGGTG	0.547000													24	52					0	0	0.002299	0	0
CAMSAP2	23271	broad.mit.edu	37	1	200826433	200826433	+	Splice_Site	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:200826433G>C	ENST00000358823.2	+	16	4282		c.e16-1		CAMSAP2_ENST00000236925.4_Splice_Site|CAMSAP2_ENST00000413307.2_Splice_Site	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2							cytoplasm|microtubule	protein binding										CCCTACCATAGGACCAAAGCT	0.323000													10	25					0	0	0.000673	0	0
PNRC1	10957	broad.mit.edu	37	6	89790894	89790894	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:89790894C>G	ENST00000336032.3	+	1	398	c.281C>G	c.(280-282)cCg>cGg	p.P94R	PNRC1_ENST00000369472.1_Intron	NM_006813.2	NP_006804.1	Q12796	PNRC1_HUMAN	proline-rich nuclear receptor coactivator 1	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(1)|large_intestine(2)|lung(3)	6		all_cancers(76;3.64e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.102)		CGGGCAGCGCCGAAGAAGCGG	0.721000										Multiple Myeloma(7;0.094)			6	14					0	0	0.001168	0	0
CPNE4	131034	broad.mit.edu	37	3	131624228	131624228	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:131624228G>T	ENST00000512055.1	-	6	2186	c.60C>A	c.(58-60)agC>agA	p.S20R	CPNE4_ENST00000429747.1_Missense_Mutation_p.S20R|CPNE4_ENST00000502818.1_Missense_Mutation_p.S38R|CPNE4_ENST00000511604.1_Missense_Mutation_p.S20R|CPNE4_ENST00000512332.1_Missense_Mutation_p.S38R			Q96A23	CPNE4_HUMAN	copine IV	20										central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						TCAGGCAGGGGCTGTTAAAGA	0.458000													18	57					1.67942e-08	3.13543e-08	0.006122	1	0
SLCO4C1	353189	broad.mit.edu	37	5	101606491	101606491	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:101606491C>T	ENST00000310954.6	-	3	925	c.639G>A	c.(637-639)agG>agA	p.R213R		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	213					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TGGTGCTATTCCTTGTTGTTA	0.333000													9	35					0	0	0.004482	0	0
TRAT1	50852	broad.mit.edu	37	3	108549617	108549617	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:108549617G>T	ENST00000295756.6	+	2	338	c.108G>T	c.(106-108)aaG>aaT	p.K36N	TRAT1_ENST00000493604.1_3'UTR|TRAT1_ENST00000426646.1_Intron	NM_016388.2	NP_057472.2	Q6PIZ9	TRAT1_HUMAN	T cell receptor associated transmembrane adaptor 1	36					cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(3)	28						ATGTGGAAAAGCAACGACAAG	0.418000													36	178					6.02846e-25	1.48821e-24	0.003271	1	0
TRIML2	205860	broad.mit.edu	37	4	189018271	189018271	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:189018271G>T	ENST00000512729.1	-	6	913	c.539C>A	c.(538-540)aCa>aAa	p.T180K	TRIML2_ENST00000326754.3_Missense_Mutation_p.T205K	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	180							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		ACTCAGGTCTGTGATATGAGC	0.498000													31	95					4.74835e-14	1.0021e-13	0.002096	1	0
ATP8A2	51761	broad.mit.edu	37	13	26343303	26343303	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:26343303G>T	ENST00000381655.2	+	26	2646	c.2504G>T	c.(2503-2505)gGt>gTt	p.G835V	ATP8A2_ENST00000491840.1_3'UTR|ATP8A2_ENST00000255283.8_Missense_Mutation_p.G795V	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	795					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GCCCACGTGGGTGTGGGAATC	0.592000													20	52					3.5997e-14	7.62893e-14	0.002299	1	0
PCDHB14	56122	broad.mit.edu	37	5	140604444	140604444	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140604444A>G	ENST00000239449.4	+	1	1367	c.1367A>G	c.(1366-1368)tAc>tGc	p.Y456C	PCDHB14_ENST00000515856.2_Missense_Mutation_p.Y303C	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		456	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAAACCTCCTACACCCTGTTC	0.592000													58	184					0	0	0.003610	0	0
KCTD8	386617	broad.mit.edu	37	4	44450416	44450416	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:44450416A>T	ENST00000360029.3	-	1	408	c.125T>A	c.(124-126)tTc>tAc	p.F42Y		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	42						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						TACTTCAGGGAAGGGCGAGGG	0.667000										HNSCC(17;0.042)			5	24					0	0	0.000602	0	0
GDF10	2662	broad.mit.edu	37	10	48438504	48438504	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:48438504G>A	ENST00000224605.2	-	1	472	c.207C>T	c.(205-207)ccC>ccT	p.P69P		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	69					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						CCTGGGCGCTGGGGCCCAACG	0.741000													8	14					0	0	0.004482	0	0
LRRC66	339977	broad.mit.edu	37	4	52860966	52860966	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:52860966C>A	ENST00000343457.3	-	4	2228	c.2222G>T	c.(2221-2223)gGg>gTg	p.G741V		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	741						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						CTTGCTTGCCCCTGAGCTCTC	0.493000													37	96					9.62906e-15	2.07133e-14	0.001287	1	0
CHEK2	11200	broad.mit.edu	37	22	29083962	29083962	+	Missense_Mutation	SNP	G	G	C	rs138839489	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:29083962G>C	ENST00000544772.1	-	16	2328	c.892C>G	c.(892-894)Cga>Gga	p.R298G	CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000402731.1_Missense_Mutation_p.R490G|CHEK2_ENST00000382565.1_Missense_Mutation_p.R139G|CHEK2_ENST00000404276.1_Missense_Mutation_p.R519G|CHEK2_ENST00000405598.1_Missense_Mutation_p.R519G|CHEK2_ENST00000403642.1_Missense_Mutation_p.R428G|CHEK2_ENST00000348295.3_Missense_Mutation_p.R490G|CHEK2_ENST00000382580.2_Missense_Mutation_p.R562G|CHEK2_ENST00000328354.6_Missense_Mutation_p.R519G|CHEK2_ENST00000382578.1_Missense_Mutation_p.R428G	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	519	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.R519G(1)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						GGCCGCTTTCGACTAGTAGAA	0.463000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	31					0	0	0.004672	0	0
OR2M3	127062	broad.mit.edu	37	1	248366631	248366631	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248366631G>T	ENST00000456743.1	+	1	300	c.262G>T	c.(262-264)Ggc>Tgc	p.G88C		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTACCTGTCTGGCAGCAAGTC	0.502000													135	417					1.41203e-78	3.67567e-78	0.003610	1	0
OR8K3	219473	broad.mit.edu	37	11	56085963	56085963	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56085963T>C	ENST00000312711.1	+	1	181	c.181T>C	c.(181-183)Ttt>Ctt	p.F61L		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					CCCTATGTACTTTTTTCTCAG	0.383000													9	180					0	0	0.000443	0	0
USP42	84132	broad.mit.edu	37	7	6189425	6189425	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:6189425G>T	ENST00000306177.5	+	13	1756	c.1598G>T	c.(1597-1599)cGc>cTc	p.R533L		NM_032172.2	NP_115548.1	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	533					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity	p.R661L(1)|p.R533L(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(2)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	35		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		TTGCCTGTTCGCCAGTGTCAG	0.428000													21	49					8.34094e-07	1.48407e-06	0.001216	1	0
ZNF716	441234	broad.mit.edu	37	7	57529257	57529257	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:57529257T>C	ENST00000420713.1	+	4	1202	c.1090T>C	c.(1090-1092)Tcc>Ccc	p.S364P		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						CTTTACCTTCTCCTCAACTCT	0.403000													8	22					0	0	0.003080	0	0
TAF5L	27097	broad.mit.edu	37	1	229730582	229730582	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:229730582C>A	ENST00000258281.2	-	5	1397	c.1232G>T	c.(1231-1233)tGg>tTg	p.W411L	TAF5L_ENST00000366676.1_Missense_Mutation_p.W411L	NM_014409.3	NP_055224.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	411					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				ATCAAATGACCACAGCCTGGC	0.547000													21	92					7.41877e-09	1.39415e-08	0.001882	1	0
CYP2C19	1557	broad.mit.edu	37	10	96535277	96535277	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:96535277G>C	ENST00000371321.3	+	3	544	c.462G>C	c.(460-462)gaG>gaC	p.E154D	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	154					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GCCTTGTGGAGGAGTTGAGAA	0.517000													39	121					0	0	0.003610	0	0
ANKRD34B	340120	broad.mit.edu	37	5	79855120	79855120	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:79855120G>T	ENST00000338682.3	-	5	1391	c.719C>A	c.(718-720)cCc>cAc	p.P240H		NM_001004441.2	NP_001004441.2	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	240						cytoplasm|nucleus				NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	28		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		GGGGAGCTTGGGCCCCTTAGG	0.527000													16	48					1.3612e-06	2.40699e-06	0.003163	1	0
NR1H4	9971	broad.mit.edu	37	12	100928694	100928694	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:100928694T>C	ENST00000548884.1	+	6	1154	c.613T>C	c.(613-615)Tct>Cct	p.S205P	NR1H4_ENST00000551379.1_Missense_Mutation_p.S219P|NR1H4_ENST00000392986.3_Missense_Mutation_p.S209P|NR1H4_ENST00000549996.1_Missense_Mutation_p.S158P|NR1H4_ENST00000188403.7_Missense_Mutation_p.S215P	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	219					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						TCAGTGTAAATCTAAGCGACT	0.413000													16	21					0	0	0.004007	0	0
C10orf99	387695	broad.mit.edu	37	10	85944465	85944465	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:85944465C>A	ENST00000372126.3	+	3	303	c.189C>A	c.(187-189)tgC>tgA	p.C63*	C10orf99_ENST00000472542.1_Intron	NM_207373.2	NP_997256.1	Q6UWK7	CJ099_HUMAN	chromosome 10 open reading frame 99	63						extracellular region				endometrium(1)|lung(1)|pancreas(1)|prostate(1)	4						GTAAACCATGCAAGCTTGAGC	0.577000													24	58					1.77063e-15	3.87531e-15	0.005443	1	0
KDM4C	23081	broad.mit.edu	37	9	6984211	6984211	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:6984211G>T	ENST00000381309.3	+	10	1726	c.1161G>T	c.(1159-1161)gaG>gaT	p.E387D	KDM4C_ENST00000428870.2_Missense_Mutation_p.E74D|KDM4C_ENST00000543771.1_Missense_Mutation_p.E387D|KDM4C_ENST00000535193.1_Missense_Mutation_p.E409D|KDM4C_ENST00000442236.2_Missense_Mutation_p.E206D|KDM4C_ENST00000536108.1_Missense_Mutation_p.E206D|KDM4C_ENST00000381306.3_Missense_Mutation_p.E387D	NM_015061.3	NP_055876.2	Q9H3R0	KDM4C_HUMAN	lysine (K)-specific demethylase 4C	387					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43						AGGCTGATGAGGAAGAGGAAG	0.498000													21	51					2.37509e-13	4.91931e-13	0.001523	1	0
RELN	5649	broad.mit.edu	37	7	103292197	103292197	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:103292197C>G	ENST00000424685.2	-	15	1962	c.1803G>C	c.(1801-1803)tgG>tgC	p.W601C	RELN_ENST00000428762.1_Missense_Mutation_p.W601C|RELN_ENST00000343529.5_Missense_Mutation_p.W601C			P78509	RELN_HUMAN	reelin	601					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GAAGGAGGGACCAGGAGCGCC	0.478000													14	32					0	0	0.001855	0	0
APPL2	55198	broad.mit.edu	37	12	105600962	105600962	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:105600962C>G	ENST00000258530.3	-	8	723	c.498G>C	c.(496-498)gaG>gaC	p.E166D	APPL2_ENST00000551662.1_Missense_Mutation_p.E172D|APPL2_ENST00000539978.2_Missense_Mutation_p.E123D|APPL2_ENST00000549573.1_5'UTR	NM_001251904.1|NM_018171.3	NP_001238833.1|NP_060641.2	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	166	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						CCGCGGCCACCTCTTTTCCGA	0.512000													14	35					0	0	0.002450	0	0
PCNX	22990	broad.mit.edu	37	14	71555910	71555910	+	Splice_Site	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:71555910A>T	ENST00000304743.2	+	30	5886	c.5438_splice	c.e30-1	p.N1814_splice	PCNX_ENST00000238570.5_Splice_Site_p.N1742_splice|PCNX_ENST00000439984.3_Splice_Site_p.N1703_splice	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1814						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TCTTAACAGTAATTTAGAGTC	0.383000													14	53					0	0	0.002450	0	0
SYNE1	23345	broad.mit.edu	37	6	152831418	152831418	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:152831418G>A	ENST00000367255.5	-	8	1092	c.491C>T	c.(490-492)cCc>cTc	p.P164L	SYNE1_ENST00000448038.1_Missense_Mutation_p.P171L|SYNE1_ENST00000466159.2_Missense_Mutation_p.P164L|SYNE1_ENST00000265368.4_Missense_Mutation_p.P164L|SYNE1_ENST00000367253.4_Missense_Mutation_p.P164L|SYNE1_ENST00000367248.3_Missense_Mutation_p.P171L|SYNE1_ENST00000423061.1_Missense_Mutation_p.P171L|SYNE1_ENST00000413186.2_Missense_Mutation_p.P164L|SYNE1_ENST00000341594.5_Missense_Mutation_p.P164L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	164	Actin-binding.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGTGGGCTGGGAGTCTCAGA	0.493000										HNSCC(10;0.0054)			25	66					0	0	0.004656	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237321	140237321	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140237321C>G	ENST00000307360.5	+	1	1688	c.1688C>G	c.(1687-1689)gCg>gGg	p.A563G	PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGCTCCCGCGCTGCTGGCG	0.687000													25	20					0	0	0.003954	0	0
GALNTL6	442117	broad.mit.edu	37	4	173873316	173873316	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:173873316G>T	ENST00000506823.1	+	10	1935	c.1278G>T	c.(1276-1278)aaG>aaT	p.K426N	GALNTL6_ENST00000508122.1_Missense_Mutation_p.K409N	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	426						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						AGCAGCTCAAGTGCAAGGACT	0.597000													15	37					2.31682e-05	3.9439e-05	0.003163	1	0
PTPDC1	138639	broad.mit.edu	37	9	96859788	96859788	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:96859788G>T	ENST00000375360.3	+	7	1118	c.778G>T	c.(778-780)Gct>Tct	p.A260S	PTPDC1_ENST00000288976.3_Missense_Mutation_p.A312S	NM_001253830.1|NM_177995.2	NP_001240759.1|NP_818931.1	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	260							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	32						CAAAGCACATGCTGTCACCTT	0.438000													129	76					1.6185e-62	4.1968e-62	0.003610	1	0
GYPA	2993	broad.mit.edu	37	4	145035886	145035886	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:145035886G>T	ENST00000360771.4	-	6	507	c.392C>A	c.(391-393)cCt>cAt	p.P131H	GYPA_ENST00000324022.10_Missense_Mutation_p.P98H|RP11-673E1.4_ENST00000506982.1_RNA|GYPA_ENST00000512064.1_Missense_Mutation_p.P118H|GYPA_ENST00000504786.1_Missense_Mutation_p.P99H|GYPA_ENST00000503627.1_Missense_Mutation_p.P86H|GYPA_ENST00000512789.1_Missense_Mutation_p.P66H|GYPA_ENST00000535709.1_Missense_Mutation_p.P105H|GYPB_ENST00000283126.7_Intron	NM_002099.6	NP_002090.4	P02724	GLPA_HUMAN	glycophorin A (MNS blood group)	131					interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10	all_hematologic(180;0.15)					GTCTGTGTCAGGTGAGGGGAG	0.328000													13	31					7.93312e-07	1.41401e-06	0.002450	1	0
GCC1	79571	broad.mit.edu	37	7	127223058	127223058	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:127223058C>T	ENST00000321407.2	-	2	1762	c.1338G>A	c.(1336-1338)gcG>gcA	p.A446A	GCC1_ENST00000497650.1_5'UTR	NM_024523.5	NP_078799.2	Q96CN9	GCC1_HUMAN	GRIP and coiled-coil domain containing 1	446						Golgi membrane|plasma membrane	protein binding	p.A446A(1)		breast(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						TTTTCCTGGCCGCAACCTGCA	0.557000													45	132					0	0	0.003214	0	0
CCR8	1237	broad.mit.edu	37	3	39374449	39374449	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:39374449C>T	ENST00000326306.4	+	2	765	c.627C>T	c.(625-627)atC>atT	p.I209I	CCR8_ENST00000545843.1_Silent_p.I126I|CCR8_ENST00000414803.1_3'UTR	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	209					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		GCTTGTTGATCCCATTCACCA	0.398000													25	34					0	0	0.003330	0	0
ARAP2	116984	broad.mit.edu	37	4	36230489	36230489	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:36230489C>G	ENST00000303965.4	-	2	1109	c.620G>C	c.(619-621)aGt>aCt	p.S207T		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	207					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AGGGAGCTTACTGAGATTTTC	0.338000													25	84					0	0	0.005443	0	0
OR2A5	393046	broad.mit.edu	37	7	143747689	143747689	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:143747689G>T	ENST00000408906.2	+	1	229	c.195G>T	c.(193-195)ctG>ctT	p.L65L		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					TCTCACACCTGGCCATCATTG	0.488000													18	77					3.52763e-06	6.16184e-06	0.004990	1	0
OR13G1	441933	broad.mit.edu	37	1	247835616	247835616	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247835616G>T	ENST00000359688.2	-	1	749	c.728C>A	c.(727-729)aCa>aAa	p.T243K	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GGTCACCACTGTGAGATGAGA	0.448000													44	42					1.41504e-22	3.44239e-22	0.002852	1	0
C9	735	broad.mit.edu	37	5	39342218	39342218	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:39342218T>A	ENST00000263408.4	-	2	253	c.158A>T	c.(157-159)cAa>cTa	p.Q53L	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	53	TSP type-1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			AGGATCGCATTGTGACCATTC	0.463000													15	66					0	0	0.003163	0	0
RANBP3L	202151	broad.mit.edu	37	5	36260950	36260950	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:36260950C>T	ENST00000296604.3	-	8	1086	c.601G>A	c.(601-603)Gat>Aat	p.D201N	RANBP3L_ENST00000502994.1_Missense_Mutation_p.D226N|RANBP3L_ENST00000515759.1_Missense_Mutation_p.D201N	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	201					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			GAACATTTATCTTCATTTGGT	0.249000													3	10					0	0	0.000248	0	0
RIMKLB	57494	broad.mit.edu	37	12	8866600	8866600	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:8866600G>T	ENST00000357529.3	+	3	1400	c.138G>T	c.(136-138)atG>atT	p.M46I	RIMKLB_ENST00000538135.1_Missense_Mutation_p.M46I|RIMKLB_ENST00000535829.1_Missense_Mutation_p.M46I|RIMKLB_ENST00000299673.5_3'UTR	NM_020734.2	NP_065785.2	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family member B	46					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			central_nervous_system(2)|kidney(3)|large_intestine(5)|lung(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						CTGTGGTGATGGATGAGGTGG	0.428000													17	26					5.01169e-05	8.4525e-05	0.004990	1	0
PCDHB16	57717	broad.mit.edu	37	5	140562178	140562178	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140562178T>C	ENST00000361016.2	+	1	1199	c.44T>C	c.(43-45)cTt>cCt	p.L15P		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		15					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGCAAGTCCTTGTTTTCTTT	0.473000													39	101					0	0	0.001287	0	0
DENND2A	27147	broad.mit.edu	37	7	140244499	140244499	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:140244499G>C	ENST00000275884.6	-	13	2663	c.2246C>G	c.(2245-2247)tCc>tGc	p.S749C	DENND2A_ENST00000492720.1_Missense_Mutation_p.S749C|DENND2A_ENST00000496613.1_Missense_Mutation_p.S749C|DENND2A_ENST00000537639.1_Missense_Mutation_p.S749C			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	749	DENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					GACGCTGAGGGAGGAGAAGAG	0.602000													8	25					0	0	0.003080	0	0
PLCG2	5336	broad.mit.edu	37	16	81979842	81979842	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:81979842G>C	ENST00000359376.3	+	31	3758	c.3544G>C	c.(3544-3546)Gtt>Ctt	p.V1182L		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	1182					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						TTCCCTCCTGGTTTTCTGTGA	0.527000													24	44					0	0	0.003330	0	0
TINAG	27283	broad.mit.edu	37	6	54214631	54214631	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:54214631C>T	ENST00000259782.4	+	7	1113	c.1017C>T	c.(1015-1017)ccC>ccT	p.P339P		NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	339					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			AGCCATGTCCCAACAACGTAG	0.443000													96	60					0	0	0.003610	0	0
ATP6V1B2	526	broad.mit.edu	37	8	20075667	20075667	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:20075667G>A	ENST00000276390.2	+	13	1310	c.1270G>A	c.(1270-1272)Gcg>Acg	p.A424T		NM_001693.3	NP_001684.2	P21281	VATB2_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	424				AC -> RA (in Ref. 7; AAA35610).	ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(1)|kidney(2)|lung(5)|prostate(1)	9				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		TCTTTAGTATGCGTGCTATGC	0.438000													36	84					0	0	0.004289	0	0
ACTN2	88	broad.mit.edu	37	1	236912520	236912520	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:236912520G>C	ENST00000366578.4	+	14	1778	c.1612G>C	c.(1612-1614)Gat>Cat	p.D538H	ACTN2_ENST00000542672.1_Missense_Mutation_p.D538H|ACTN2_ENST00000546208.1_Missense_Mutation_p.D32H	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	538					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGCTATGGAGGATCTGCAAGA	0.443000													17	65					0	0	0.006122	0	0
CETN1	1068	broad.mit.edu	37	18	580859	580859	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:580859C>T	ENST00000327228.3	+	1	493	c.451C>T	c.(451-453)Cgg>Tgg	p.R151W		NM_004066.1	NP_004057.1	Q12798	CETN1_HUMAN	centrin, EF-hand protein, 1	151	EF-hand 4.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(2)	25						CGAAGCTGATCGGGATGGGGA	0.547000													46	173					0	0	0.002852	0	0
KCNJ12	3768	broad.mit.edu	37	17	21318738	21318738	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:21318738C>T	ENST00000583088.1	+	3	979	c.84C>T	c.(82-84)gcC>gcT	p.A28A	KCNJ12_ENST00000331718.5_Silent_p.A28A	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		TGTCGGGCGCCAACGGCTTCG	0.657000										Prostate(3;0.18)			5	43					0	0	0.001168	0	0
SCN3A	6328	broad.mit.edu	37	2	166019263	166019263	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:166019263C>A	ENST00000360093.3	-	8	1261	c.770G>T	c.(769-771)tGt>tTt	p.C257F	SCN3A_ENST00000283254.7_Missense_Mutation_p.C257F|SCN3A_ENST00000409101.3_Missense_Mutation_p.C257F	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	257						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CACGCTCAGACAGAACACAGT	0.478000													37	36					1.90571e-15	4.1664e-15	0.004289	1	0
TUBA3C	7278	broad.mit.edu	37	13	19753636	19753636	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:19753636T>A	ENST00000400113.3	-	2	175	c.71A>T	c.(70-72)tAc>tTc	p.Y24F		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	24					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TTCCAGGCAGTACAGTTCCCA	0.512000													50	45					0	0	0.003610	0	0
SMARCA4	6597	broad.mit.edu	37	19	11144853	11144853	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:11144853G>T	ENST00000358026.2	+	28	4212	c.3928G>T	c.(3928-3930)Gag>Tag	p.E1310*	SMARCA4_ENST00000589677.1_Nonsense_Mutation_p.E1277*|SMARCA4_ENST00000429416.3_Nonsense_Mutation_p.E1310*|SMARCA4_ENST00000344626.4_Nonsense_Mutation_p.E1310*|SMARCA4_ENST00000541122.2_Nonsense_Mutation_p.E1277*|SMARCA4_ENST00000450717.3_Nonsense_Mutation_p.E1277*|SMARCA4_ENST00000444061.3_Nonsense_Mutation_p.E1277*|SMARCA4_ENST00000413806.3_Nonsense_Mutation_p.E1277*|SMARCA4_ENST00000590574.1_Nonsense_Mutation_p.E1277*	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1310					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.E1310*(2)|p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CGCCCGGCACGAGGAGGAGTT	0.597000			"""F, N, Mis"""		NSCLC								24	44					2.21704e-12	4.48096e-12	0.002780	1	0
ZFHX4	79776	broad.mit.edu	37	8	77765155	77765155	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:77765155C>A	ENST00000521891.2	+	10	6446	c.5998C>A	c.(5998-6000)Cca>Aca	p.P2000T	ZFHX4_ENST00000050961.6_Missense_Mutation_p.P1955T|ZFHX4_ENST00000518282.1_Missense_Mutation_p.P1974T|ZFHX4_ENST00000455469.2_Missense_Mutation_p.P1955T	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1955	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCCATCTTCTCCAGAAACGcc	0.507000										HNSCC(33;0.089)			8	18					0.000157383	0.000261914	0.003080	1	0
ERCC6	2074	broad.mit.edu	37	10	50667067	50667067	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:50667067C>G	ENST00000355832.5	-	21	4354	c.4276G>C	c.(4276-4278)Gac>Cac	p.D1426H	ERCC6_ENST00000542458.1_Missense_Mutation_p.D796H|RP11-123B3.2_ENST00000423283.1_RNA	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	1426	Ubiquitin-binding domain (UBD).				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						ACCAGAAGGTCATCGTGTTCT	0.527000								Direct reversal of damage;Nucleotide excision repair (NER)					25	70					0	0	0.003330	0	0
EEF1DP3	196549	broad.mit.edu	37	13	32527088	32527088	+	RNA	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:32527088C>G	ENST00000428783.1	+	0	788																											GAGCCCCCGGCCAAGAAGCTA	0.607000													12	15					0	0	0.001855	0	0
PXDN	7837	broad.mit.edu	37	2	1658260	1658260	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1658260C>A	ENST00000252804.4	-	15	1908	c.1858G>T	c.(1858-1860)Gga>Tga	p.G620*		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	620					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AACGGATCTCCATTTCGACTG	0.428000													15	32					7.93312e-07	1.41401e-06	0.002450	1	0
BHMT2	23743	broad.mit.edu	37	5	78378765	78378765	+	Missense_Mutation	SNP	G	G	A	rs147230129		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:78378765G>A	ENST00000255192.3	+	5	650	c.584G>A	c.(583-585)aGg>aAg	p.R195K	BHMT2_ENST00000521567.1_Missense_Mutation_p.R131K|DMGDH_ENST00000520388.1_Intron	NM_017614.4	NP_060084.2	Q9H2M3	BHMT2_HUMAN	betaine--homocysteine S-methyltransferase 2	195	Hcy-binding.				methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			endometrium(2)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	15		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)	TGTGCTGTGAGGCTGGTGAAG	0.463000													50	114					0	0	0.003610	0	0
SERPINA4	5267	broad.mit.edu	37	14	95033445	95033445	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95033445G>A	ENST00000557004.1	+	3	1209	c.788G>A	c.(787-789)tGc>tAc	p.C263Y	SERPINA4_ENST00000555095.1_Missense_Mutation_p.C263Y|SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000298841.5_Missense_Mutation_p.C263Y			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	263					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		TACTTGCCCTGCTCGGTGCTA	0.493000													15	44					0	0	0.004990	0	0
USP29	57663	broad.mit.edu	37	19	57641686	57641686	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:57641686C>T	ENST00000254181.4	+	4	2097	c.1643C>T	c.(1642-1644)cCt>cTt	p.P548L	USP29_ENST00000598197.1_Missense_Mutation_p.P548L	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	548					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACCAAACCACCTCTTCCCTTG	0.418000													52	143					0	0	0.003610	0	0
EWSR1	2130	broad.mit.edu	37	22	29684679	29684679	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:29684679G>C	ENST00000397938.2	+	8	1197	c.878G>C	c.(877-879)aGc>aCc	p.S293T	EWSR1_ENST00000331029.7_Missense_Mutation_p.S293T|EWSR1_ENST00000333395.6_Missense_Mutation_p.S293T|EWSR1_ENST00000332050.6_Intron|EWSR1_ENST00000406548.1_Missense_Mutation_p.S293T|EWSR1_ENST00000414183.2_Missense_Mutation_p.S299T|EWSR1_ENST00000332035.6_Missense_Mutation_p.S237T	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GAGAACCGGAGCATGAGTGGC	0.592000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								18	25					0	0	0.004990	0	0
XIRP2	129446	broad.mit.edu	37	2	168105477	168105477	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:168105477A>T	ENST00000409195.1	+	9	7664	c.7575A>T	c.(7573-7575)ccA>ccT	p.P2525P	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Silent_p.P2525P|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Silent_p.P2303P|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2350					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATTCATTTCCAGAGAGTTCAG	0.348000													32	51					0	0	0.002836	0	0
POU4F3	5459	broad.mit.edu	37	5	145719828	145719828	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:145719828T>A	ENST00000230732.4	+	2	927	c.838T>A	c.(838-840)Tcc>Acc	p.S280T	CTC-359M8.1_ENST00000515598.1_RNA	NM_002700.2	NP_002691.1	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	280					sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAAACGCACGTCCATCGCGGC	0.612000													21	45					0	0	0.001216	0	0
RGS8	85397	broad.mit.edu	37	1	182640845	182640845	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:182640845G>A	ENST00000258302.4	-	2	116	c.27C>T	c.(25-27)ctC>ctT	p.L9L	RGS8_ENST00000491420.2_5'UTR|RGS8_ENST00000367557.4_5'UTR|RGS8_ENST00000367556.1_5'UTR|RGS8_ENST00000483095.2_5'UTR	NM_033345.2	NP_203131.1	P57771	RGS8_HUMAN	regulator of G-protein signaling 8	0					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	5						GATGGTCAGAGAGGCTTCGGG	0.498000													23	73					0	0	0.001882	0	0
MUC17	140453	broad.mit.edu	37	7	100676773	100676773	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:100676773T>C	ENST00000306151.4	+	3	2140	c.2076T>C	c.(2074-2076)agT>agC	p.S692S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	692	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CATTAACAAGTATGCCTGTCA	0.493000													213	468					0	0	0.003610	0	0
LLGL2	3993	broad.mit.edu	37	17	73569302	73569302	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:73569302A>G	ENST00000392550.3	+	20	2785	c.2668A>G	c.(2668-2670)Atc>Gtc	p.I890V	LLGL2_ENST00000577200.1_Missense_Mutation_p.I890V|LLGL2_ENST00000167462.5_Missense_Mutation_p.I890V	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	890					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CTACAGCTGCATCCGCCGGGA	0.662000													28	59					0	0	0.001512	0	0
MYH2	4620	broad.mit.edu	37	17	10433044	10433044	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10433044G>T	ENST00000245503.5	-	24	3338	c.2954C>A	c.(2953-2955)aCa>aAa	p.T985K	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron|MYH2_ENST00000397183.2_Missense_Mutation_p.T985K	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	985					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CATCTCTTCTGTGAGGTTTTT	0.478000													73	152					4.81439e-37	1.22932e-36	0.003610	1	0
SFRP4	6424	broad.mit.edu	37	7	37951858	37951858	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:37951858C>G	ENST00000436072.2	-	4	1031	c.654G>C	c.(652-654)gtG>gtC	p.V218V	EPDR1_ENST00000476620.1_Intron	NM_003014.3	NP_003005.2	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related protein 4	218	NTR.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						CTTTTACATCCACCACCGTTG	0.433000													18	46					0	0	0.006122	0	0
OR11G2	390439	broad.mit.edu	37	14	20666322	20666322	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20666322C>T	ENST00000357366.3	+	1	828	c.828C>T	c.(826-828)ttC>ttT	p.F276F		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	276					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GAAAGGCTTTCTCCACCTGTG	0.517000													57	145					0	0	0.003610	0	0
NPEPL1	79716	broad.mit.edu	37	20	57268861	57268861	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:57268861C>T	ENST00000356091.6	+	2	507	c.219C>T	c.(217-219)taC>taT	p.Y73Y	NPEPL1_ENST00000525967.1_Silent_p.Y45Y|STX16-NPEPL1_ENST00000530122.1_3'UTR|NPEPL1_ENST00000525817.1_Silent_p.Y25Y	NM_024663.3	NP_078939.3	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	73					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			ACCTGAACTACGCCACCGTGG	0.672000													29	34					0	0	0.002445	0	0
GRHL2	79977	broad.mit.edu	37	8	102656368	102656368	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:102656368C>G	ENST00000251808.3	+	13	1865	c.1527C>G	c.(1525-1527)gtC>gtG	p.V509V	GRHL2_ENST00000395927.1_Silent_p.V493V|GRHL2_ENST00000517674.1_3'UTR	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	509						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			GTGGCAGTGTCCTTGTTAAAC	0.463000													8	25					0	0	0.004482	0	0
KCNK18	338567	broad.mit.edu	37	10	118957144	118957144	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:118957144G>T	ENST00000334549.1	+	1	145	c.145G>T	c.(145-147)Gtc>Ttc	p.V49F		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	49						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		GGACGGCCAGGTCCTGGTGGC	0.572000													16	49					3.45872e-05	5.87777e-05	0.004007	1	0
RIMS2	9699	broad.mit.edu	37	8	105027684	105027684	+	Splice_Site	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:105027684G>A	ENST00000436393.2	+	18	2828	c.2587_splice	c.e18+1	p.E863_splice	RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000507740.1_Intron|RIMS2_ENST00000406091.3_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	323	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ACCTTATGAAGGTCTGTACAT	0.363000										HNSCC(12;0.0054)			4	5					0	0	0.000248	0	0
SULF1	23213	broad.mit.edu	37	8	70476335	70476335	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:70476335G>C	ENST00000260128.4	+	5	842	c.125G>C	c.(124-126)cGa>cCa	p.R42P	SULF1_ENST00000458141.2_Missense_Mutation_p.R42P|SULF1_ENST00000419716.3_Missense_Mutation_p.R42P|SULF1_ENST00000402687.4_Missense_Mutation_p.R42P	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	42					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AAAAACATCCGACCCAACATT	0.483000													28	70					0	0	0.004656	0	0
CMYA5	202333	broad.mit.edu	37	5	79034639	79034639	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:79034639C>A	ENST00000446378.2	+	2	10082	c.10051C>A	c.(10051-10053)Cgt>Agt	p.R3351S		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3351						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TGTTCTGGAGCGTGCAGATGA	0.488000													21	46					4.35082e-09	8.22231e-09	0.001523	1	0
LEPR	3953	broad.mit.edu	37	1	66036415	66036415	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:66036415C>A	ENST00000349533.6	+	4	485	c.300C>A	c.(298-300)tcC>tcA	p.S100S	LEPR_ENST00000371059.3_Silent_p.S100S|LEPR_ENST00000371060.3_Silent_p.S100S|LEPR_ENST00000406510.3_5'UTR|LEPR_ENST00000344610.8_Silent_p.S100S|LEPR_ENST00000371058.1_Silent_p.S100S|LEPR_ENST00000462765.1_3'UTR	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	100					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GAAACTGCTCCTTATGTGCAG	0.333000													36	23					1.96642e-18	4.5104e-18	0.001485	1	0
BRINP3	339479	broad.mit.edu	37	1	190067933	190067933	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:190067933T>A	ENST00000367462.3	-	8	1747	c.1516A>T	c.(1516-1518)Aga>Tga	p.R506*	FAM5C_ENST00000534846.1_Nonsense_Mutation_p.R404*|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		506						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					TCTATTCGTCTGTCCGTTTTC	0.488000													53	127					0	0	0.003610	0	0
ALOX12B	242	broad.mit.edu	37	17	7977057	7977057	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:7977057C>G	ENST00000319144.4	-	13	1933	c.1673G>C	c.(1672-1674)cGa>cCa	p.R558P	ALOX12B_ENST00000577351.1_Intron	NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	558	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						AGGCACGGTTCGCAAGCACCT	0.627000										Multiple Myeloma(8;0.094)	OREG0024152	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	29					0	0	0.004482	0	0
NECAB1	64168	broad.mit.edu	37	8	91929810	91929810	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:91929810C>A	ENST00000417640.2	+	6	785	c.448C>A	c.(448-450)Ctg>Atg	p.L150M		NM_022351.4	NP_071746.1	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	150					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)	12			BRCA - Breast invasive adenocarcinoma(11;0.0499)			CCAGAATTCCCTGGAATGTGC	0.403000													19	33					0.00152264	0.00249261	0.001523	1	0
FGD5	152273	broad.mit.edu	37	3	14939485	14939485	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:14939485G>A	ENST00000285046.5	+	6	3059	c.2949G>A	c.(2947-2949)cgG>cgA	p.R983R	FGD5_ENST00000543601.1_Silent_p.R742R|FGD5_ENST00000476851.1_3'UTR	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	983	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						TCCTGGCCCGGGAGCAGGGGT	0.592000													24	38					0	0	0.003954	0	0
SLC6A5	9152	broad.mit.edu	37	11	20623176	20623176	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:20623176G>T	ENST00000525748.1	+	2	778	c.505G>T	c.(505-507)Gtg>Ttg	p.V169L		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	169					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity	p.V169M(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	AATCACGTCCGTGCTCCCGGG	0.652000													12	31					6.40141e-05	0.000107782	0.000978	1	0
CEACAM18	729767	broad.mit.edu	37	19	51984682	51984682	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:51984682A>G	ENST00000396477.4	+	3	457	c.436A>G	c.(436-438)Agc>Ggc	p.S146G	CEACAM18_ENST00000451626.1_Missense_Mutation_p.S207G	NM_001278392.1	NP_001265321.1	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	207						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CGTCAATGCCAGCTCCCTGGT	0.502000													13	35					0	0	0.001855	0	0
PTCRA	171558	broad.mit.edu	37	6	42890971	42890971	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:42890971T>G	ENST00000304672.1	+	2	346	c.265T>G	c.(265-267)Ttg>Gtg	p.L89V	PTCRA_ENST00000441198.1_Missense_Mutation_p.L64V|PTCRA_ENST00000446507.1_Intron	NM_001243168.1|NM_138296.2	NP_001230097.1|NP_612153.2	Q6ISU1	PTCRA_HUMAN	pre T-cell antigen receptor alpha	89						integral to membrane	receptor activity			large_intestine(2)|lung(4)|ovary(2)	8	Colorectal(47;0.196)		all cancers(41;0.000731)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			CTGGACCAACTTGGCCCATCT	0.622000													29	156					0	0	0.005443	0	0
GLYATL1	92292	broad.mit.edu	37	11	58714591	58714591	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:58714591C>A	ENST00000317391.4	+	4	371	c.31C>A	c.(31-33)Ctg>Atg	p.L11M	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000300079.5_Intron	NM_001220494.1	NP_001207423.1	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	11						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	CCATAAGCTGCTGGCCCTATA	0.478000													14	28					1.5842e-08	2.96042e-08	0.001855	1	0
MYH15	22989	broad.mit.edu	37	3	108211406	108211406	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:108211406G>A	ENST00000273353.3	-	10	928	c.872C>T	c.(871-873)gCt>gTt	p.A291V		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	291	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CCTCTCTCCAGCCTGCTGGAA	0.368000													14	44					0	0	0.004007	0	0
C1QB	713	broad.mit.edu	37	1	22987522	22987522	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:22987522C>A	ENST00000509305.1	+	3	745	c.399C>A	c.(397-399)cgC>cgA	p.R133R	C1QB_ENST00000314933.6_Silent_p.R135R			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	135	C1q.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCCCCCTGCGCCGGGACCAGA	0.592000													63	50					5.10652e-33	1.29241e-32	0.003610	1	0
UROC1	131669	broad.mit.edu	37	3	126218903	126218903	+	Missense_Mutation	SNP	C	C	A	rs142723755	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:126218903C>A	ENST00000290868.2	-	12	1293	c.1240G>T	c.(1240-1242)Gca>Tca	p.A414S	UROC1_ENST00000383579.3_Missense_Mutation_p.A474S	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	414					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		ctcctACCTGCTCTCTGGGCC	0.632000													15	64					2.23348e-06	3.92179e-06	0.004007	1	0
EEFSEC	60678	broad.mit.edu	37	3	128060074	128060074	+	Splice_Site	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:128060074A>T	ENST00000254730.6	+	5	840		c.e5-1		EEFSEC_ENST00000483569.1_Splice_Site|EEFSEC_ENST00000483457.1_Splice_Site	NM_021937.3	NP_068756.2	P57772	SELB_HUMAN	eukaryotic elongation factor, selenocysteine-tRNA-specific							cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)	25						ACTCCCCATCAGGTGGTGAAG	0.562000													26	100					0	0	0.001786	0	0
OR2M5	127059	broad.mit.edu	37	1	248309365	248309365	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248309365G>T	ENST00000366476.1	+	1	916	c.916G>T	c.(916-918)Gga>Tga	p.G306*		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GAAAGTGTTAGGAAAGGGCAA	0.443000													38	52					1.57351e-24	3.8749e-24	0.003755	1	0
OR4K13	390433	broad.mit.edu	37	14	20502160	20502160	+	Missense_Mutation	SNP	G	G	T	rs150686832	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20502160G>T	ENST00000315693.2	-	1	759	c.758C>A	c.(757-759)cCg>cAg	p.P253Q		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AAAGACACACGGAGCAAAGAA	0.413000													22	46					2.89027e-11	5.74333e-11	0.002299	1	0
MYH4	4622	broad.mit.edu	37	17	10354160	10354160	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10354160G>T	ENST00000255381.2	-	29	4028	c.3918C>A	c.(3916-3918)tcC>tcA	p.S1306S	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1306					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GTTTGCCTCGGGATAGCTGAG	0.393000													31	57					1.55811e-20	3.71393e-20	0.001512	1	0
PXDNL	137902	broad.mit.edu	37	8	52384809	52384809	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:52384809G>T	ENST00000356297.4	-	8	850	c.750C>A	c.(748-750)acC>acA	p.T250T	PXDNL_ENST00000543296.1_Silent_p.T250T	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	250	Ig-like C2-type 1.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGAAGTAGACGGTATTTCCTG	0.428000													35	93					1.67305e-13	3.4832e-13	0.001287	1	0
DDI1	414301	broad.mit.edu	37	11	103908508	103908508	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:103908508A>G	ENST00000302259.3	+	1	1201	c.958A>G	c.(958-960)Ata>Gta	p.I320V	PDGFD_ENST00000302251.5_Intron|PDGFD_ENST00000393158.2_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	320					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CTCTTTCTCCATACTTGAGGA	0.453000													32	60					0	0	0.002836	0	0
FTMT	94033	broad.mit.edu	37	5	121187730	121187730	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:121187730C>T	ENST00000321339.1	+	1	81	c.72C>T	c.(70-72)tgC>tgT	p.C24C		NM_177478.1	NP_803431.1	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial	24					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	33		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		CGGTGCGCTGCTGCTTCGCGC	0.731000													4	34					0	0	0.000248	0	0
TNIK	23043	broad.mit.edu	37	3	170781743	170781743	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:170781743G>T	ENST00000436636.2	-	33	4354	c.4010C>A	c.(4009-4011)gCa>gAa	p.A1337E	TNIK_ENST00000357327.5_Missense_Mutation_p.A1308E|TNIK_ENST00000341852.6_Missense_Mutation_p.A1253E|TNIK_ENST00000284483.8_Missense_Mutation_p.A1329E|TNIK_ENST00000464785.1_5'UTR|TNIK_ENST00000538048.1_Missense_Mutation_p.A1289E|TNIK_ENST00000369326.5_Missense_Mutation_p.A1315E|TNIK_ENST00000460047.1_Missense_Mutation_p.A1274E|TNIK_ENST00000488470.1_Missense_Mutation_p.A1282E|TNIK_ENST00000470834.1_Missense_Mutation_p.A1300E|TNIK_ENST00000475336.1_Missense_Mutation_p.A1245E	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	1337					actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCGCACGGATGCAAAAAATAC	0.403000													52	40					6.81593e-30	1.70995e-29	0.003610	1	0
OR4M1	441670	broad.mit.edu	37	14	20248502	20248502	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20248502C>A	ENST00000315957.4	+	1	102	c.21C>A	c.(19-21)acC>acA	p.T7T		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAAATTACACCAAGGTGACAG	0.338000													26	178					7.16444e-05	0.000120528	0.003954	1	0
PCDH15	65217	broad.mit.edu	37	10	55569197	55569197	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:55569197G>T	ENST00000395445.1	-	36	5007	c.4613C>A	c.(4612-4614)aCa>aAa	p.T1538K	PCDH15_ENST00000395440.1_Missense_Mutation_p.T472K|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000395438.1_3'UTR|PCDH15_ENST00000395442.1_Missense_Mutation_p.T403K|PCDH15_ENST00000395446.1_Missense_Mutation_p.T734K	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CTTCCATGTTGTGTATGTAGG	0.398000										HNSCC(58;0.16)			52	151					1.35964e-18	3.14377e-18	0.003610	1	0
CENPQ	55166	broad.mit.edu	37	6	49456174	49456174	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:49456174G>T	ENST00000335783.3	+	7	681	c.587G>T	c.(586-588)aGa>aTa	p.R196I		NM_018132.3	NP_060602.2	Q7L2Z9	CENPQ_HUMAN	centromere protein Q	196					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(4)|ovary(2)|prostate(1)	11	Lung NSC(77;0.0128)					GAAGAGGAGAGAGTAAAACAG	0.313000													36	35					3.93418e-24	9.67635e-24	0.004289	1	0
HTR3E	285242	broad.mit.edu	37	3	183823166	183823166	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:183823166C>A	ENST00000415389.2	+	6	1137	c.671C>A	c.(670-672)aCc>aAc	p.T224N	HTR3E_ENST00000436361.2_Missense_Mutation_p.T224N|HTR3E_ENST00000425359.2_Missense_Mutation_p.T209N|HTR3E_ENST00000335304.2_Missense_Mutation_p.T239N|HTR3E_ENST00000440596.2_Missense_Mutation_p.T250N	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	224						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			AGCAAGGCCACCGCAAAGTTG	0.527000													17	70					1.15088e-07	2.09412e-07	0.004007	1	0
FOXB2	442425	broad.mit.edu	37	9	79635323	79635323	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:79635323G>T	ENST00000376708.1	+	1	753	c.753G>T	c.(751-753)tcG>tcT	p.S251S		NM_001013735.1	NP_001013757.1	Q5VYV0	FOXB2_HUMAN	forkhead box B2	251					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|lung(8)|ovary(1)	10						GGCTGGGCTCGgccgccgccg	0.746000													7	17					2.7689e-08	5.15508e-08	0.001984	1	0
GSC	145258	broad.mit.edu	37	14	95234860	95234860	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95234860C>A	ENST00000238558.3	-	3	951	c.742G>T	c.(742-744)Gaa>Taa	p.E248*		NM_173849.2	NP_776248.1	P56915	GSC_HUMAN	goosecoid homeobox	248					gastrulation|middle ear morphogenesis		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1		all_cancers(154;0.0896)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.202)|Epithelial(152;0.239)		CTTTTACCTTCCTCTTCCCTC	0.562000													40	104					8.16277e-20	1.9161e-19	0.001485	1	0
TARS	6897	broad.mit.edu	37	5	33457373	33457373	+	Silent	SNP	G	G	A	rs113811412		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:33457373G>A	ENST00000265112.3	+	9	1160	c.849G>A	c.(847-849)acG>acA	p.T283T	TARS_ENST00000455217.2_Silent_p.T316T|TARS_ENST00000541634.1_Silent_p.T179T|TARS_ENST00000414361.2_Silent_p.T162T|TARS_ENST00000502553.1_Silent_p.T283T	NM_152295.4	NP_689508.3	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	283					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity	p.T283T(1)		NS(1)|biliary_tract(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)	29					L-Threonine(DB00156)	ATTCCTCCACGTACTGGGAAG	0.388000													11	38					0	0	0.001855	0	0
DDR2	4921	broad.mit.edu	37	1	162724444	162724444	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:162724444G>A	ENST00000367922.2	+	6	654	c.216G>A	c.(214-216)tgG>tgA	p.W72*	DDR2_ENST00000367921.3_Nonsense_Mutation_p.W72*	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	72	F5/8 type C.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			ATGGAGCCTGGTGCCCTGAGA	0.557000													38	74					0	0	0.001287	0	0
UNC5D	137970	broad.mit.edu	37	8	35406972	35406972	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:35406972G>T	ENST00000287272.2	+	2	286	c.266G>T	c.(265-267)gGc>gTc	p.G89V	UNC5D_ENST00000420357.1_Missense_Mutation_p.G89V|UNC5D_ENST00000416672.1_Missense_Mutation_p.G89V|UNC5D_ENST00000404895.2_Missense_Mutation_p.G89V|UNC5D_ENST00000453357.2_Missense_Mutation_p.G84V			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	89	Ig-like.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		AAATGCAACGGCGAGTGGGTC	0.507000													17	29					5.01169e-05	8.4525e-05	0.004990	1	0
OR2J3	442186	broad.mit.edu	37	6	29080330	29080330	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:29080330T>A	ENST00000377169.1	+	1	663	c.663T>A	c.(661-663)taT>taA	p.Y221*		NM_001005216.2	NP_001005216.2	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J, member 3	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24						TCACTTCTTATGGTGCCATCG	0.448000													16	137					0	0	0.003163	0	0
DMBT1	1755	broad.mit.edu	37	10	124339216	124339216	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:124339216G>A	ENST00000368909.3	+	10	908	c.802G>A	c.(802-804)Gcc>Acc	p.A268T	DMBT1_ENST00000368955.3_Missense_Mutation_p.A268T|DMBT1_ENST00000330163.4_Missense_Mutation_p.A268T|DMBT1_ENST00000344338.3_Missense_Mutation_p.A268T|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368956.2_Missense_Mutation_p.A268T|DMBT1_ENST00000338354.3_Missense_Mutation_p.A268T	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	268	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CACCAATGATGCCAATGTGGT	0.607000													139	346					0	0	0.003610	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481907	140481907	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140481907G>C	ENST00000231130.2	+	1	1674	c.1674G>C	c.(1672-1674)tcG>tcC	p.S558S		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		558	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGACAACTCGCCCTTCGTGC	0.711000													30	76					0	0	0.003755	0	0
PCNT	5116	broad.mit.edu	37	21	47851899	47851899	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:47851899G>T	ENST00000359568.5	+	38	8628	c.8521G>T	c.(8521-8523)Gcc>Tcc	p.A2841S	PCNT_ENST00000480896.1_Intron	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2841					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GGAGGTAAGTGCCACACTGAA	0.567000													17	39					1.78486e-19	4.18484e-19	0.000958	1	0
MACF1	23499	broad.mit.edu	37	1	39763349	39763349	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:39763349A>T	ENST00000564288.1	+	21	3190	c.2413A>T	c.(2413-2415)Aaa>Taa	p.K805*	MACF1_ENST00000539005.1_Nonsense_Mutation_p.K810*|MACF1_ENST00000545844.1_Nonsense_Mutation_p.K810*|MACF1_ENST00000567887.1_Nonsense_Mutation_p.K842*|MACF1_ENST00000361689.2_Nonsense_Mutation_p.K810*|MACF1_ENST00000372915.3_Nonsense_Mutation_p.K810*|MACF1_ENST00000317713.7_Nonsense_Mutation_p.K810*			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	810					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGATTCCATTAAACGAAAATA	0.463000													46	26					0	0	0.003214	0	0
COL12A1	1303	broad.mit.edu	37	6	75893061	75893061	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:75893061C>T	ENST00000322507.8	-	10	1905	c.1596G>A	c.(1594-1596)gtG>gtA	p.V532V	COL12A1_ENST00000483888.2_Silent_p.V532V|COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000416123.2_Silent_p.V532V	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	532	VWFA 2.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CCTTGCTAGGCACAAATATTT	0.393000													41	105					0	0	0.002522	0	0
KIAA1432	57589	broad.mit.edu	37	9	5757415	5757415	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:5757415T>C	ENST00000414202.2	+	17	2147	c.1956T>C	c.(1954-1956)agT>agC	p.S652S	KIAA1432_ENST00000251879.6_Silent_p.S652S|KIAA1432_ENST00000418622.3_Silent_p.S573S|KIAA1432_ENST00000381532.2_Silent_p.S573S|KIAA1432_ENST00000449720.2_Silent_p.S536S	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	652						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CATCAGTGAGTACAGAGAATG	0.413000													36	102					0	0	0.004878	0	0
PTCD3	55037	broad.mit.edu	37	2	86350830	86350830	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:86350830G>T	ENST00000254630.7	+	9	727	c.661G>T	c.(661-663)Gaa>Taa	p.E221*	PTCD3_ENST00000409277.3_Missense_Mutation_p.R179S	NM_017952.5	NP_060422.4	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3	221						mitochondrion	protein binding			NS(1)|breast(2)|endometrium(3)|kidney(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	22						TCAGGAAGAGGAAAATGATGA	0.383000													14	36					3.27435e-08	6.06798e-08	0.002450	1	0
NEMF	9147	broad.mit.edu	37	14	50312932	50312932	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:50312932C>A	ENST00000298310.5	-	4	732	c.283G>T	c.(283-285)Gtg>Ttg	p.V95L	NEMF_ENST00000545773.1_Intron|NEMF_ENST00000546046.1_Missense_Mutation_p.V95L|NEMF_ENST00000556672.1_Missense_Mutation_p.V95L			O60524	NEMF_HUMAN	nuclear export mediator factor	95						cytoplasm|nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(13)|liver(1)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	36						ATTCTATCCACACCAAGCTGT	0.358000													13	32					2.32078e-09	4.44448e-09	0.003163	1	0
TGFBR2	7048	broad.mit.edu	37	3	30691784	30691784	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:30691784A>G	ENST00000295754.5	+	3	668	c.286A>G	c.(286-288)Aca>Gca	p.T96A	TGFBR2_ENST00000359013.4_Missense_Mutation_p.T121A	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)	96					activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						CGAGAACATAACACTAGAGAC	0.428000													27	34					0	0	0.001061	0	0
PTPRR	5801	broad.mit.edu	37	12	71078504	71078504	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:71078504T>C	ENST00000283228.2	-	9	1791	c.1339A>G	c.(1339-1341)Att>Gtt	p.I447V	PTPRR_ENST00000342084.4_Missense_Mutation_p.I335V|PTPRR_ENST00000549308.1_Missense_Mutation_p.I202V|PTPRR_ENST00000440835.2_Missense_Mutation_p.I202V|PTPRR_ENST00000378778.1_Missense_Mutation_p.I241V	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	447	Tyrosine-protein phosphatase.				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TTAGCATTAATGTAGGTGCTC	0.299000													24	59					0	0	0.004656	0	0
ATP2C1	27032	broad.mit.edu	37	3	130683850	130683850	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:130683850T>A	ENST00000510168.1	+	14	1633	c.1083T>A	c.(1081-1083)acT>acA	p.T361T	ATP2C1_ENST00000505330.1_Silent_p.T345T|ATP2C1_ENST00000513801.1_Silent_p.T345T|ATP2C1_ENST00000533801.2_Silent_p.T356T|ATP2C1_ENST00000359644.3_Silent_p.T361T|ATP2C1_ENST00000393221.4_Silent_p.T395T|ATP2C1_ENST00000422190.2_Silent_p.T361T|ATP2C1_ENST00000508532.1_Silent_p.T361T|ATP2C1_ENST00000428331.2_Silent_p.T361T|ATP2C1_ENST00000507488.2_Silent_p.T345T|ATP2C1_ENST00000328560.8_Silent_p.T361T|ATP2C1_ENST00000504948.1_Silent_p.T345T|ATP2C1_ENST00000504381.1_Silent_p.T306T			P98194	AT2C1_HUMAN	ATPase, Ca++ transporting, type 2C, member 1	361					actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|prostate(2)|skin(2)|urinary_tract(1)	39					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	ATGAAATGACTGTTACTCACA	0.333000									Hailey-Hailey disease				55	43					0	0	0.003610	0	0
HELZ	9931	broad.mit.edu	37	17	65119097	65119097	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:65119097C>T	ENST00000358691.5	-	26	3785	c.3619G>A	c.(3619-3621)Gtg>Atg	p.V1207M	HELZ_ENST00000580168.1_Missense_Mutation_p.V1208M	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GGTAAAGGCACCGACATAACT	0.378000													11	47					0	0	0.001368	0	0
DGKI	9162	broad.mit.edu	37	7	137271843	137271843	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:137271843C>A	ENST00000453654.1	-	13	1064	c.525_splice	c.e13+1	p.G175_splice	DGKI_ENST00000446122.1_Splice_Site_p.G475_splice|DGKI_ENST00000288490.5_Splice_Site_p.G475_splice|DGKI_ENST00000424189.2_Splice_Site_p.G475_splice			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	475					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						CAGTTCTTACCCCTCCCCAGT	0.552000													18	54					5.3912e-06	9.37621e-06	0.006122	1	0
SULT1C3	442038	broad.mit.edu	37	2	108863754	108863754	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:108863754G>T	ENST00000329106.2	+	1	104	c.104G>T	c.(103-105)tGg>tTg	p.W35L	SULT1C3_ENST00000376700.1_Missense_Mutation_p.W35L	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	35						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						TCAAAAGAATGGTGGGAAAAA	0.378000													18	53					3.99206e-14	8.45154e-14	0.000958	1	0
NCR1	9437	broad.mit.edu	37	19	55417664	55417664	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:55417664T>A	ENST00000594765.1	+	2	67	c.42T>A	c.(40-42)tgT>tgA	p.C14*	NCR1_ENST00000338835.5_Nonsense_Mutation_p.C14*|NCR1_ENST00000350790.5_Nonsense_Mutation_p.C14*|NCR1_ENST00000598576.1_Intron|NCR1_ENST00000447255.1_Nonsense_Mutation_p.C14*|NCR1_ENST00000291890.4_Nonsense_Mutation_p.C14*|NCR1_ENST00000357397.5_Intron			O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	14					cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(193;0.0449)		CAGGGCTGTGTCTGAGTCAGA	0.612000													14	56					0	0	0.001855	0	0
UBE2Q2	92912	broad.mit.edu	37	15	76171514	76171514	+	Silent	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:76171514T>G	ENST00000267938.4	+	8	1192	c.810T>G	c.(808-810)ctT>ctG	p.L270L	UBE2Q2_ENST00000561851.1_Silent_p.L254L|UBE2Q2_ENST00000338677.4_Silent_p.L270L|UBE2Q2_ENST00000569423.1_Silent_p.L235L	NM_173469.2	NP_775740.1	Q8WVN8	UB2Q2_HUMAN	ubiquitin-conjugating enzyme E2Q family member 2	270					protein K48-linked ubiquitination	cytoplasm	ATP binding|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	12						ATATTTTGCTTAACTTCTCTT	0.343000													12	20					0	0	0.000978	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281445	49281445	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:49281445C>A	ENST00000282018.3	+	1	495	c.492C>A	c.(490-492)atC>atA	p.I164I		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	164					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	TCATATGGATCCTTATCATGG	0.493000													53	65					5.13769e-22	1.24233e-21	0.003610	1	0
TMEM252	169693	broad.mit.edu	37	9	71152371	71152371	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:71152371T>A	ENST00000377311.3	-	2	369	c.317A>T	c.(316-318)gAg>gTg	p.E106V		NM_153237.1	NP_694969.1			transmembrane protein 252																		CTTTTCCACCTCAAGGCTCTC	0.498000													16	40					0	0	0.004007	0	0
CUBN	8029	broad.mit.edu	37	10	17168764	17168764	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:17168764T>A	ENST00000377833.4	-	4	448	c.383A>T	c.(382-384)cAg>cTg	p.Q128L	CUBN_ENST00000377823.1_Missense_Mutation_p.Q128L	NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	128					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACCTACCTGCTGCAAGCCTTG	0.393000													20	30					0	0	0.001882	0	0
IGHV3-66	28412	broad.mit.edu	37	14	107131154	107131154	+	RNA	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:107131154G>A	ENST00000390632.2	-	0	305																											TGCGTAGTATGTGCTACCACA	0.537000													77	120					0	0	0.003610	0	0
ITGA11	22801	broad.mit.edu	37	15	68650827	68650827	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:68650827T>C	ENST00000423218.2	-	6	664	c.569A>G	c.(568-570)aAa>aGa	p.K190R	ITGA11_ENST00000562826.1_5'UTR|ITGA11_ENST00000315757.7_Missense_Mutation_p.K190R			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	190	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	GTAAAACTTTTTCAGGATGTT	0.542000													6	13					0	0	0.001984	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075769	145075769	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:145075769G>C	ENST00000369359.4	-	1	132	c.94C>G	c.(94-96)Cgg>Ggg	p.R32G	PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R32G|PDE4DIP_ENST00000369345.4_Missense_Mutation_p.R32G|PDE4DIP_ENST00000369348.3_Missense_Mutation_p.R32G			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCCCGGACCGGTAAGGCGTG	0.716000			T	PDGFRB	MPD								11	70					0	0	0.000673	0	0
CDH23	64072	broad.mit.edu	37	10	73550138	73550138	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:73550138A>G	ENST00000224721.6	+	45	6037	c.6032A>G	c.(6031-6033)cAg>cGg	p.Q2011R		NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	2006	Cadherin 19.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CTGGGTGCCCAGAGTGGCCTC	0.632000													11	36					0	0	0.000673	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68919756	68919756	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:68919756A>T	ENST00000356291.2	-	10	1247	c.1188T>A	c.(1186-1188)gaT>gaA	p.D396E	RP11-453E17.1_ENST00000500538.2_RNA	NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	396	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						TGTCATGATTATCATAAACCA	0.368000													16	45					0	0	0.004007	0	0
PARD3	56288	broad.mit.edu	37	10	34666965	34666965	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:34666965A>T	ENST00000374789.3	-	10	1794	c.1469T>A	c.(1468-1470)gTg>gAg	p.V490E	PARD3_ENST00000340077.5_Missense_Mutation_p.V490E|PARD3_ENST00000374773.1_Missense_Mutation_p.V490E|PARD3_ENST00000374788.3_Missense_Mutation_p.V490E|PARD3_ENST00000545260.1_Missense_Mutation_p.V446E|PARD3_ENST00000374776.1_Missense_Mutation_p.V490E|PARD3_ENST00000374794.3_Missense_Mutation_p.V446E|PARD3_ENST00000544292.1_Missense_Mutation_p.V220E|PARD3_ENST00000346874.4_Missense_Mutation_p.V490E|PARD3_ENST00000545693.1_Missense_Mutation_p.V490E|PARD3_ENST00000374790.3_Missense_Mutation_p.V446E|PARD3_ENST00000350537.4_Missense_Mutation_p.V490E	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	490	PDZ 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				AATGTTTTTCACATAGATTGG	0.478000													30	86					0	0	0.001271	0	0
ACSS1	84532	broad.mit.edu	37	20	24995843	24995843	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:24995843C>A	ENST00000537502.1	-	6	2552	c.1021G>T	c.(1021-1023)Gcc>Tcc	p.A341S	ACSS1_ENST00000432802.2_Missense_Mutation_p.A424S|ACSS1_ENST00000542618.1_Missense_Mutation_p.A303S|ACSS1_ENST00000323482.4_Missense_Mutation_p.A424S			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	424					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CACTCCCAGGCCTCACAGTTG	0.532000													20	39					7.41877e-09	1.39415e-08	0.001882	1	0
YEATS2	55689	broad.mit.edu	37	3	183508669	183508669	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:183508669G>A	ENST00000305135.5	+	21	3193	c.2998G>A	c.(2998-3000)Gcc>Acc	p.A1000T		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1000					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TGTGAGCCAGGCCACCGTGGG	0.597000													32	140					0	0	0.001786	0	0
EPHA5	2044	broad.mit.edu	37	4	66356139	66356139	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:66356139C>G	ENST00000273854.3	-	5	1958	c.1358G>C	c.(1357-1359)gGa>gCa	p.G453A	EPHA5_ENST00000511294.1_Missense_Mutation_p.G453A|EPHA5_ENST00000432638.2_Intron|EPHA5_ENST00000354839.4_Missense_Mutation_p.G453A	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	453	Fibronectin type-III 1.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						CTGCCGGGCTCCTGGGCTCAA	0.468000										TSP Lung(17;0.13)			21	58					0	0	0.001523	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291747	141291747	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:141291747G>A	ENST00000247452.3	-	3	374	c.27C>T	c.(25-27)ttC>ttT	p.F9F		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	9						cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					CAACGTTGCGGAATGGAACGC	0.537000										HNSCC(46;0.14)			49	32					0	0	0.003610	0	0
KBTBD3	143879	broad.mit.edu	37	11	105925058	105925058	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:105925058C>A	ENST00000526793.1	-	3	517	c.358G>T	c.(358-360)Gat>Tat	p.D120Y	KBTBD3_ENST00000534815.1_Missense_Mutation_p.D41Y|KBTBD3_ENST00000531837.1_Missense_Mutation_p.D120Y	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	116										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		TCCACATTATCATCTGTTATT	0.328000													8	25					0.00307968	0.0049967	0.003080	1	0
LAMA1	284217	broad.mit.edu	37	18	7024446	7024446	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:7024446G>A	ENST00000389658.3	-	18	2515	c.2422C>T	c.(2422-2424)Ctc>Ttc	p.L808F		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	808	Laminin EGF-like 7.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCATCATTGAGGTGGCAGGTG	0.438000													8	73					0	0	0.003080	0	0
AMER3	205147	broad.mit.edu	37	2	131520349	131520349	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:131520349G>A	ENST00000423981.1	+	2	814	c.704G>A	c.(703-705)tGt>tAt	p.C235Y	AMER3_ENST00000321420.4_Missense_Mutation_p.C235Y	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		AGGGCCCTGTGTGAGGACGTG	0.662000													26	130					0	0	0.001786	0	0
PCSK6	5046	broad.mit.edu	37	15	101872152	101872152	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:101872152C>T	ENST00000348070.1	-	15	1939	c.1940G>A	c.(1939-1941)cGg>cAg	p.R647Q	PCSK6_ENST00000561177.1_5'UTR|PCSK6_ENST00000358417.3_Missense_Mutation_p.R647Q	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	648					glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CTCCAGCATCCGCGAGCGGGA	0.567000													12	19					0	0	0.001368	0	0
BNC2	54796	broad.mit.edu	37	9	16437135	16437135	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:16437135G>A	ENST00000380672.4	-	6	1114	c.1057C>T	c.(1057-1059)Cgg>Tgg	p.R353W	BNC2_ENST00000380666.2_Missense_Mutation_p.R353W|BNC2_ENST00000380667.2_Missense_Mutation_p.R286W|BNC2_ENST00000545497.1_Missense_Mutation_p.R258W	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding	p.R353W(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		CTGGGTTCCCGCAGCCTCAAC	0.468000													30	101					0	0	0.001271	0	0
TBX22	50945	broad.mit.edu	37	X	79286337	79286337	+	Missense_Mutation	SNP	T	T	G	rs144871606	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:79286337T>G	ENST00000442340.1	+	9	1420	c.930T>G	c.(928-930)agT>agG	p.S310R	TBX22_ENST00000373294.5_Missense_Mutation_p.S430R|TBX22_ENST00000373291.1_Missense_Mutation_p.S310R|TBX22_ENST00000373296.3_Missense_Mutation_p.S430R	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	430					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						AAGACTCCAGTGATCAGTATC	0.433000													41	36					0	0	0.001485	0	0
OR2T12	127064	broad.mit.edu	37	1	248458876	248458876	+	Missense_Mutation	SNP	T	T	A	rs11339452		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248458876T>A	ENST00000317996.1	-	1	4	c.5A>T	c.(4-6)gAg>gTg	p.E2V		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E2fs*2(1)|p.E2G(1)		endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATTTCTCATCTCCATAATTTC	0.428000													45	60					0	0	0.003610	0	0
EDA2R	60401	broad.mit.edu	37	X	65835806	65835806	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:65835806T>G	ENST00000374719.3	-	2	113	c.57A>C	c.(55-57)caA>caC	p.Q19H	EDA2R_ENST00000456230.2_Missense_Mutation_p.Q19H|EDA2R_ENST00000396050.1_Missense_Mutation_p.Q19H|EDA2R_ENST00000253392.5_Missense_Mutation_p.Q19H|EDA2R_ENST00000450752.1_Missense_Mutation_p.Q19H|EDA2R_ENST00000451436.2_Missense_Mutation_p.N14T	NM_021783.3	NP_068555.1	Q9HAV5	TNR27_HUMAN	ectodysplasin A2 receptor	19					cell differentiation|embryo development|epidermis development|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13						GACCACACCGTTGGCAGGTGA	0.502000													8	4					0	0	0.004482	0	0
ZNF479	90827	broad.mit.edu	37	7	57188157	57188157	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:57188157T>G	ENST00000331162.4	-	5	1235	c.965A>C	c.(964-966)gAg>gCg	p.E322A		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			GCAGGGTTTCTCTCCAGTATG	0.443000													15	37					0	0	0.004990	0	0
CACNA1E	777	broad.mit.edu	37	1	181759621	181759621	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:181759621C>T	ENST00000526775.1	+	43	5935	c.5770C>T	c.(5770-5772)Ccc>Tcc	p.P1924S	CACNA1E_ENST00000357570.5_Missense_Mutation_p.P1894S|CACNA1E_ENST00000358338.5_Missense_Mutation_p.P1875S|CACNA1E_ENST00000367573.2_Missense_Mutation_p.P1943S|CACNA1E_ENST00000360108.3_Missense_Mutation_p.P1924S|CACNA1E_ENST00000367570.1_Missense_Mutation_p.P1943S|CACNA1E_ENST00000367567.4_Missense_Mutation_p.P1550S	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1943					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TCCACTCTCTCCCCAGGATAT	0.498000													9	35					0	0	0.000443	0	0
RIN3	79890	broad.mit.edu	37	14	93118666	93118666	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:93118666C>G	ENST00000216487.7	+	6	1431	c.1272C>G	c.(1270-1272)gaC>gaG	p.D424E	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	424	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				GCCCTGAGGACACGCCCCGGG	0.642000													22	50					0	0	0.001523	0	0
KRT12	3859	broad.mit.edu	37	17	39019473	39019473	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:39019473C>A	ENST00000251643.4	-	6	1241	c.1218G>T	c.(1216-1218)gaG>gaT	p.E406D	RP5-1110E20.1_ENST00000579136.1_RNA	NM_000223.3	NP_000214.1	Q99456	K1C12_HUMAN	keratin 12	406	Coil 2.|Rod.				visual perception	intermediate filament	structural molecule activity	p.E406D(1)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	15		Breast(137;0.000301)				CGTTCTGGCGCTCTGCGTCCG	0.672000													18	26					3.32936e-07	6.00901e-07	0.006122	1	0
IGKV1-5	28299	broad.mit.edu	37	2	89247251	89247251	+	RNA	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:89247251A>G	ENST00000496168.1	-	0	224																											TGGGAGCCAGAGCAGCAGGAG	0.517000													50	137					0	0	0.003610	0	0
OR2A12	346525	broad.mit.edu	37	7	143793100	143793100	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:143793100A>G	ENST00000408949.2	+	1	960	c.900A>G	c.(898-900)ctA>ctG	p.L300L		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					AAGGGGCTCTAAAGAGAGTCC	0.453000													68	186					0	0	0.003610	0	0
RFTN1	23180	broad.mit.edu	37	3	16475401	16475401	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:16475401G>T	ENST00000334133.4	-	3	561	c.289C>A	c.(289-291)Ctg>Atg	p.L97M	RFTN1_ENST00000432519.1_Missense_Mutation_p.L61M	NM_015150.1	NP_055965.1	Q14699	RFTN1_HUMAN	raftlin, lipid raft linker 1	97						plasma membrane				central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	38						ATGTGCTCCAGGGGCGTCTTC	0.597000													50	103					2.55665e-31	6.44622e-31	0.003610	1	0
POMT1	10585	broad.mit.edu	37	9	134394277	134394277	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:134394277G>A	ENST00000423007.1	+	15	1861	c.1419G>A	c.(1417-1419)ggG>ggA	p.G473G	POMT1_ENST00000541219.1_Silent_p.G251G|RP11-334J6.6_ENST00000415423.1_RNA|POMT1_ENST00000341012.7_Silent_p.G419G|POMT1_ENST00000372228.3_Silent_p.G495G|POMT1_ENST00000402686.3_Silent_p.G473G|POMT1_ENST00000419118.2_Silent_p.G321G|POMT1_ENST00000485278.1_3'UTR|POMT1_ENST00000404875.2_Silent_p.G356G|POMT1_ENST00000354713.4_Silent_p.G443G	NM_001136113.1	NP_001129585.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1	495	MIR 3.				multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		AGATCGTCGGGGAGAAGCTGT	0.677000													22	47					0	0	0.002299	0	0
ZNF10	7556	broad.mit.edu	37	12	133733348	133733348	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133733348A>T	ENST00000248211.6	+	5	1738	c.1516A>T	c.(1516-1518)Aag>Tag	p.K506*	ZNF10_ENST00000426665.2_Nonsense_Mutation_p.K506*|ZNF268_ENST00000416488.1_Intron|ZNF10_ENST00000402932.2_Nonsense_Mutation_p.K372*|CTD-2140B24.4_ENST00000540096.2_Intron	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TGACCTCATTAAGCACCAGAG	0.413000													13	42					0	0	0.001368	0	0
PTPN22	26191	broad.mit.edu	37	1	114376998	114376998	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:114376998G>T	ENST00000359785.5	-	15	2093	c.1958C>A	c.(1957-1959)tCa>tAa	p.S653*	PTPN22_ENST00000528414.1_Nonsense_Mutation_p.S598*|PTPN22_ENST00000420377.2_Nonsense_Mutation_p.S653*|PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000538253.1_Nonsense_Mutation_p.S409*|PTPN22_ENST00000525799.1_Nonsense_Mutation_p.S526*	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	653					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCATTCCAGTGATGTTCCAAT	0.363000													26	71					1.1804e-14	2.53646e-14	0.003954	1	0
TRANK1	9881	broad.mit.edu	37	3	36899135	36899135	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:36899135G>T	ENST00000429976.2	-	12	2193	c.1946C>A	c.(1945-1947)aCt>aAt	p.T649N	TRANK1_ENST00000301807.6_Missense_Mutation_p.T99N|TRANK1_ENST00000428977.2_Missense_Mutation_p.T99N			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	649					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TGTTCTGGCAGTGGCACCACA	0.597000													35	34					1.26612e-14	2.71775e-14	0.003271	1	0
ZNF540	163255	broad.mit.edu	37	19	38103945	38103945	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:38103945T>A	ENST00000592533.1	+	5	2096	c.1764T>A	c.(1762-1764)ttT>ttA	p.F588L	ZNF540_ENST00000589117.1_Missense_Mutation_p.F556L|ZNF540_ENST00000316433.4_Missense_Mutation_p.F588L|ZNF540_ENST00000343599.5_Missense_Mutation_p.F588L	NM_152606.4	NP_689819.1			zinc finger protein 540											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(13)|lung(8)|skin(1)	28			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGAAGGCCTTTAGTCGTAGTG	0.408000													18	51					0	0	0.004990	0	0
XRCC1	7515	broad.mit.edu	37	19	44051050	44051050	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:44051050T>A	ENST00000262887.5	-	11	1826	c.1279A>T	c.(1279-1281)Aag>Tag	p.K427*	XRCC1_ENST00000543982.1_Nonsense_Mutation_p.K396*			P18887	XRCC1_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 1	427					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Prostate(69;0.0153)				TGAGGAAGCTTGGGGGCTTCA	0.617000								Other BER factors					18	64					0	0	0.006122	0	0
OBSCN	84033	broad.mit.edu	37	1	228492877	228492877	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:228492877G>C	ENST00000570156.2	+	54	14394	c.14320G>C	c.(14320-14322)Gcc>Ccc	p.A4774P	OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000366707.4_Missense_Mutation_p.A1451P|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000284548.11_Intron	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3817					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CACAGAAGGGGCCACGGCTAT	0.567000													22	58					0	0	0.002299	0	0
NOTCH4	4855	broad.mit.edu	37	6	32169141	32169141	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:32169141C>T	ENST00000375023.3	-	22	4030	c.3892G>A	c.(3892-3894)Gcc>Acc	p.A1298T		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1298					cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						ACCAGCAGGGCCAGGGAGGGC	0.637000													45	25					0	0	0.002852	0	0
AP4B1	10717	broad.mit.edu	37	1	114442738	114442738	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:114442738C>T	ENST00000369569.1	-	5	1182	c.902G>A	c.(901-903)cGc>cAc	p.R301H	AP4B1-AS1_ENST00000419536.1_RNA|AP4B1_ENST00000369566.3_Missense_Mutation_p.R208H|AP4B1_ENST00000369567.1_Missense_Mutation_p.R133H|AP4B1_ENST00000256658.4_Missense_Mutation_p.R301H	NM_001253852.1	NP_001240781.1	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1 subunit	301					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|prostate(3)	25	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAGATCTGGCGTACATGACA	0.473000													41	92					0	0	0.005524	0	0
ADAM11	4185	broad.mit.edu	37	17	42854579	42854579	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:42854579C>T	ENST00000200557.6	+	21	1896	c.1727C>T	c.(1726-1728)aCg>aTg	p.T576M	ADAM11_ENST00000535346.1_Missense_Mutation_p.T376M	NM_002390.4	NP_002381.2	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11	576	Cys-rich.				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Prostate(33;0.0959)				GTGGAGGGGACGGAGCGTGGG	0.647000													9	35					0	0	0.000443	0	0
KIAA1919	91749	broad.mit.edu	37	6	111587866	111587866	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:111587866G>T	ENST00000368847.4	+	4	1454	c.1101G>T	c.(1099-1101)atG>atT	p.M367I		NM_153369.2	NP_699200.2	Q5TF39	NAGT1_HUMAN	KIAA1919	367					carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			large_intestine(3)|lung(2)|ovary(4)|skin(3)	12		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		TGGGAGAAATGGCTATTCCTG	0.423000													34	97					1.30988e-24	3.22964e-24	0.002096	1	0
AHCTF1	25909	broad.mit.edu	37	1	247013403	247013403	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247013403C>A	ENST00000366508.1	-	33	6146	c.6010G>T	c.(6010-6012)Gcc>Tcc	p.A2004S	AHCTF1_ENST00000391829.2_Missense_Mutation_p.A1969S|AHCTF1_ENST00000326225.3_Missense_Mutation_p.A1978S|AHCTF1_ENST00000470300.1_5'UTR			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	1969	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTAGGTATGGCAGACATATCA	0.428000													32	126					8.16721e-17	1.82738e-16	0.002096	1	0
GALNTL5	168391	broad.mit.edu	37	7	151711783	151711783	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:151711783A>G	ENST00000392800.2	+	8	1335	c.1081A>G	c.(1081-1083)Atc>Gtc	p.I361V	GALNTL5_ENST00000431418.2_Missense_Mutation_p.I361V	NM_145292.3	NP_660335.2	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5	361	Catalytic subdomain B.					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(11)|ovary(2)|prostate(2)|skin(3)	32	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		AGTAGGACATATCAGTAAGAA	0.408000													22	57					0	0	0.001882	0	0
OR6S1	341799	broad.mit.edu	37	14	21109748	21109748	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:21109748G>T	ENST00000320704.3	-	1	102	c.103C>A	c.(103-105)Ctt>Att	p.L35I		NM_001001968.1	NP_001001968.1	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S, member 1	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		AGATAGACAAGAAGAAACACA	0.478000													37	93					2.47316e-13	5.11714e-13	0.003271	1	0
NBAS	51594	broad.mit.edu	37	2	15470842	15470842	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:15470842C>A	ENST00000281513.5	-	36	4252	c.4227G>T	c.(4225-4227)tgG>tgT	p.W1409C	NBAS_ENST00000441750.1_Missense_Mutation_p.W1289C	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	1409										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						TAGCAGTGGTCCAGCGCAATA	0.468000													19	57					2.4624e-09	4.69775e-09	0.001216	1	0
FLRT2	23768	broad.mit.edu	37	14	86087868	86087868	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:86087868C>T	ENST00000330753.4	+	2	777	c.10C>T	c.(10-12)Cag>Tag	p.Q4*	FLRT2_ENST00000554746.1_Nonsense_Mutation_p.Q4*	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	4					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		AATGGGCCTACAGACCACAAA	0.443000													24	73					0	0	0.003330	0	0
LILRA6	79168	broad.mit.edu	37	19	54742904	54742904	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54742904G>T	ENST00000396365.2	-	8	1410	c.1371C>A	c.(1369-1371)gtC>gtA	p.V457V	LILRB3_ENST00000407860.2_Intron|LILRA6_ENST00000245621.5_Silent_p.V440V|LILRA6_ENST00000391735.3_Intron|LILRA6_ENST00000419410.2_Intron|LILRA6_ENST00000270464.5_Intron|LILRA6_ENST00000440558.2_Intron	NM_024318.2	NP_077294.2			leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6											central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(20)|ovary(3)|skin(2)|urinary_tract(2)	38	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGAACACCAGGACCAAGCCTG	0.577000													19	55					1.33834e-09	2.57284e-09	0.000958	1	0
TCEB3B	51224	broad.mit.edu	37	18	44560992	44560992	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:44560992G>T	ENST00000332567.4	-	1	996	c.644C>A	c.(643-645)cCc>cAc	p.P215H	KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	215					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TTTCCCCTGGGGTTGGCCCTG	0.662000													22	9					2.00529e-23	4.92007e-23	0.003330	1	0
CDH20	28316	broad.mit.edu	37	18	59203814	59203814	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:59203814C>T	ENST00000262717.4	+	8	1758	c.1360C>T	c.(1360-1362)Cgg>Tgg	p.R454W	CDH20_ENST00000538374.1_Missense_Mutation_p.R454W|CDH20_ENST00000536675.2_Missense_Mutation_p.R454W			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	454	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				ACCCCTAGACCGGGAAGAATT	0.408000													52	55					0	0	0.003610	0	0
DUSP9	1852	broad.mit.edu	37	X	152915660	152915660	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:152915660A>C	ENST00000342782.3	+	4	1320	c.1055A>C	c.(1054-1056)cAg>cCg	p.Q352P	DUSP9_ENST00000370167.4_Missense_Mutation_p.Q352P			Q99956	DUS9_HUMAN	dual specificity phosphatase 9	352	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGCCACTCGCAGGAGCAGGGC	0.632000													40	36					0	0	0.001287	0	0
CACHD1	57685	broad.mit.edu	37	1	65138857	65138857	+	Missense_Mutation	SNP	G	G	T	rs148780022		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:65138857G>T	ENST00000371073.2	+	18	2527	c.2527G>T	c.(2527-2529)Gac>Tac	p.D843Y	CACHD1_ENST00000290039.5_Missense_Mutation_p.D792Y|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	843	Cache 2.				calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						CATAATGGAGGACAGGGGTTA	0.453000													99	79					2.65435e-51	6.83861e-51	0.003610	1	0
COL25A1	84570	broad.mit.edu	37	4	109745314	109745314	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:109745314G>T	ENST00000399126.1	-	35	2391	c.1861C>A	c.(1861-1863)Cag>Aag	p.Q621K	COL25A1_ENST00000399132.1_Intron|COL25A1_ENST00000399127.1_Missense_Mutation_p.Q624K	NM_032518.2	NP_115907.2	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	411	Collagen-like 7.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		GGTACATGCTGGGATGGAGAG	0.453000													27	59					2.44723e-14	5.21401e-14	0.004656	1	0
GJA5	2702	broad.mit.edu	37	1	147231343	147231343	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:147231343C>A	ENST00000271348.2	-	2	165	c.4G>T	c.(4-6)Ggc>Tgc	p.G2C	GJA5_ENST00000369237.1_Missense_Mutation_p.G2C	NM_005266.5|NM_181703.2	NP_005257.2|NP_859054.1	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	2					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CTCCAATCGCCCATCTTGGCA	0.493000													16	69					1.99824e-07	3.62609e-07	0.004990	1	0
KRT78	196374	broad.mit.edu	37	12	53233651	53233651	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:53233651G>T	ENST00000359499.4	-	7	846	c.835C>A	c.(835-837)Ctg>Atg	p.L279M	KRT78_ENST00000304620.4_Missense_Mutation_p.L389M			Q8N1N4	K2C78_HUMAN	keratin 78	389	Linker 12.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						AGCCGGGCCAGGTTCTGCTTG	0.637000													20	50					7.21436e-19	1.67778e-18	0.001216	1	0
TIE1	7075	broad.mit.edu	37	1	43770797	43770797	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:43770797C>A	ENST00000372476.3	+	2	413	c.334C>A	c.(334-336)Cgg>Agg	p.R112R	TIE1_ENST00000441333.2_Silent_p.R112R|TIE1_ENST00000538015.1_Silent_p.R112R	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	112					mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGCTGGGGCGCGGCGCACGCG	0.701000													12	16					4.3838e-07	7.88377e-07	0.001855	1	0
FOXA2	3170	broad.mit.edu	37	20	22563227	22563227	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:22563227G>A	ENST00000419308.2	-	2	837	c.635C>T	c.(634-636)tCc>tTc	p.S212F	FOXA2_ENST00000377115.4_Missense_Mutation_p.S212F|FOXA2_ENST00000319993.4_Missense_Mutation_p.S218F	NM_021784.4	NP_068556.2	Q9Y261	FOXA2_HUMAN	forkhead box A2	212					cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|urinary_tract(1)	22	Lung NSC(19;0.188)					GTCGTTGAAGGAGAGCGAGTG	0.607000													15	37					0	0	0.000958	0	0
ZNF385D	79750	broad.mit.edu	37	3	21465512	21465512	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:21465512G>T	ENST00000281523.2	-	7	1415	c.897C>A	c.(895-897)ccC>ccA	p.P299P		NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	299						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						TAGGTTTCGGGGGCTTCCCAG	0.418000													34	40					2.54651e-27	6.30968e-27	0.001485	1	0
WBSCR28	135886	broad.mit.edu	37	7	73279506	73279506	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:73279506G>T	ENST00000320531.2	+	2	292	c.256G>T	c.(256-258)Gtc>Ttc	p.V86F		NM_182504.3	NP_872310.2	Q6UE05	WBS28_HUMAN	Williams-Beuren syndrome chromosome region 28	86						integral to membrane				breast(2)|kidney(2)|lung(6)|skin(1)	11		Lung NSC(55;0.159)				TCTGATACAGGTCCCCGTATG	0.692000													34	75					4.02929e-09	7.62185e-09	0.002096	1	0
CD36	948	broad.mit.edu	37	7	80285972	80285972	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:80285972C>T	ENST00000435819.1	+	7	921	c.237C>T	c.(235-237)aaC>aaT	p.N79N	CD36_ENST00000534394.1_Silent_p.N3N|CD36_ENST00000432207.1_Silent_p.N79N|CD36_ENST00000441109.2_3'UTR|CD36_ENST00000538969.1_Silent_p.N79N|CD36_ENST00000309881.7_Silent_p.N79N|CD36_ENST00000394788.3_Silent_p.N79N|CD36_ENST00000544133.1_Silent_p.N79N|CD36_ENST00000447544.2_Silent_p.N79N|CD36_ENST00000433696.2_Silent_p.N79N			P16671	CD36_HUMAN	CD36 molecule (thrombospondin receptor)	79					cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|large_intestine(1)|lung(6)|ovary(1)	21						TGATGATGAACAGCAGCAACA	0.388000													12	53					0	0	0.001368	0	0
C12orf29	91298	broad.mit.edu	37	12	88433979	88433979	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:88433979A>T	ENST00000356891.3	+	2	348	c.145A>T	c.(145-147)Ata>Tta	p.I49L	C12orf29_ENST00000548757.2_3'UTR	NM_001009894.2	NP_001009894.2	Q8N999	CL029_HUMAN	chromosome 12 open reading frame 29	49										large_intestine(3)|lung(1)|ovary(1)	5						AGATGCAGATATATACAGTGC	0.308000													23	42					0	0	0.003330	0	0
C1GALT1	56913	broad.mit.edu	37	7	7278538	7278538	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:7278538T>A	ENST00000436587.2	+	3	1096	c.873T>A	c.(871-873)taT>taA	p.Y291*	C1GALT1_ENST00000223122.2_Nonsense_Mutation_p.Y291*|C1GALT1_ENST00000402468.3_Nonsense_Mutation_p.Y291*	NM_020156.3	NP_064541.1	Q9NS00	C1GLT_HUMAN	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	291					angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding			breast(1)|kidney(1)|lung(3)|prostate(1)|urinary_tract(1)	7				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		ATTACAACTATTATCCTCCTG	0.313000													10	26					0	0	0.000978	0	0
C18orf56	494514	broad.mit.edu	37	18	657969	657969	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:657969G>C	ENST00000323813.3	-	1	371	c.279C>G	c.(277-279)tcC>tcG	p.S93S	TYMS_ENST00000323274.10_Intron|TYMS_ENST00000323250.5_Intron|TYMS_ENST00000323224.7_Intron|C18orf56_ENST00000585033.1_Silent_p.S93S	NM_001012716.2	NP_001012734.2	Q8TAI1	CR056_HUMAN	chromosome 18 open reading frame 56	93							protein binding										GGCCCCTGCGGGACGGGTGGC	0.716000													3	14					0	0	0.004672	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74911282	74911282	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:74911282A>G	ENST00000289575.5	+	11	2008	c.1613A>G	c.(1612-1614)aAc>aGc	p.N538S	SLCO2B1_ENST00000428359.2_Missense_Mutation_p.N516S|SLCO2B1_ENST00000341411.4_Missense_Mutation_p.N311S|SLCO2B1_ENST00000525650.1_Missense_Mutation_p.N394S|SLCO2B1_ENST00000454962.2_Missense_Mutation_p.N311S|SLCO2B1_ENST00000532236.1_Missense_Mutation_p.N422S|SLCO2B1_ENST00000531756.1_Missense_Mutation_p.N283S	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	538	Kazal-like.				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	TTCTACACCAACTGCAGCTGC	0.622000													19	87					0	0	0.006122	0	0
TSSC2	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:3427765G>C	ENST00000529482.1	+	0	882																											CACACGTCCTGCAGTGGCCTG	0.602000													3	64					0	0	0.004672	0	0
MYH4	4622	broad.mit.edu	37	17	10348361	10348361	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10348361G>A	ENST00000255381.2	-	37	5508	c.5398C>T	c.(5398-5400)Cgt>Tgt	p.R1800C	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1800					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TCATCCAGACGGAGCTGCAGA	0.562000													60	111					0	0	0.003610	0	0
CCDC142	84865	broad.mit.edu	37	2	74709692	74709692	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:74709692G>A	ENST00000393965.3	-	1	669	c.273C>T	c.(271-273)ctC>ctT	p.L91L	CCDC142_ENST00000290418.4_Silent_p.L91L|CCDC142_ENST00000471713.1_Intron	NM_032779.3	NP_116168.3	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	91										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	16						ACACCGCCCGGAGACGCTGCA	0.716000													7	8					0	0	0.001984	0	0
RINT1	60561	broad.mit.edu	37	7	105204334	105204334	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:105204334G>A	ENST00000257700.2	+	12	2057	c.1826G>A	c.(1825-1827)cGt>cAt	p.R609H		NM_021930.4	NP_068749.3	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	609	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						ATGTTGACCCGTCAAGTAGAC	0.388000													12	43					0	0	0.000978	0	0
DHRS7	51635	broad.mit.edu	37	14	60622799	60622799	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:60622799G>T	ENST00000216500.5	-	3	660	c.205C>A	c.(205-207)Cag>Aag	p.Q69K	PCNXL4_ENST00000406949.1_Intron|DHRS7_ENST00000557185.1_Missense_Mutation_p.Q69K|PCNXL4_ENST00000553898.1_Intron|DHRS7_ENST00000536410.2_Missense_Mutation_p.Q19K			Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	69							binding|oxidoreductase activity			endometrium(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	5				OV - Ovarian serous cystadenocarcinoma(108;0.121)		TTAGACAACTGGTAAGCCAGC	0.478000													23	67					2.89027e-11	5.74333e-11	0.002299	1	0
SBSN	374897	broad.mit.edu	37	19	36018649	36018649	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:36018649C>T	ENST00000452271.2	-	1	563	c.535G>A	c.(535-537)Ggg>Agg	p.G179R	SBSN_ENST00000518157.1_Intron	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	178	Ala/Gly/His-rich.					extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CCGGCCTGCCCTGCAGCATGG	0.637000													8	23					0	0	0.003080	0	0
MECOM	2122	broad.mit.edu	37	3	168806817	168806817	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:168806817G>T	ENST00000464456.1	-	14	4165	c.2965C>A	c.(2965-2967)Cag>Aag	p.Q989K	MECOM_ENST00000392736.3_Missense_Mutation_p.Q998K|MECOM_ENST00000264674.3_Missense_Mutation_p.Q1063K|MECOM_ENST00000472280.1_Missense_Mutation_p.Q999K|MECOM_ENST00000468789.1_Missense_Mutation_p.Q998K|MECOM_ENST00000460814.1_Missense_Mutation_p.Q989K|MECOM_ENST00000433243.2_Missense_Mutation_p.Q999K|MECOM_ENST00000494292.1_Missense_Mutation_p.Q1177K	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TGTAACGGCTGCTTAAGTTCC	0.393000													21	82					4.4004e-07	7.90654e-07	0.003330	1	0
STEAP3	55240	broad.mit.edu	37	2	120003239	120003239	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:120003239T>A	ENST00000354888.5	+	3	671	c.167T>A	c.(166-168)gTg>gAg	p.V56E	STEAP3_ENST00000450943.2_Missense_Mutation_p.V56E|STEAP3-AS1_ENST00000454260.1_RNA|STEAP3_ENST00000393107.2_Missense_Mutation_p.V56E|STEAP3_ENST00000409811.1_Missense_Mutation_p.V56E|STEAP3_ENST00000393110.2_Missense_Mutation_p.V66E|STEAP3_ENST00000425223.2_Missense_Mutation_p.V56E|STEAP3_ENST00000393106.2_Missense_Mutation_p.V56E|STEAP3_ENST00000393108.2_Missense_Mutation_p.V56E	NM_182915.2	NP_878919.2	Q658P3	STEA3_HUMAN	STEAP family member 3, metalloreductase	56					apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	17						AAAGTGGTGGTGGGGAGCCGC	0.637000													11	31					0	0	0.000673	0	0
PTPRC	5788	broad.mit.edu	37	1	198721748	198721748	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:198721748A>T	ENST00000367376.2	+	31	3521	c.3350A>T	c.(3349-3351)cAg>cTg	p.Q1117L	PTPRC_ENST00000594404.1_Missense_Mutation_p.Q956L|PTPRC_ENST00000348564.6_Missense_Mutation_p.Q958L|PTPRC_ENST00000442510.2_Missense_Mutation_p.Q1119L|PTPRC_ENST00000352140.3_Missense_Mutation_p.Q1069L	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1117	Tyrosine-protein phosphatase 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						ACTGTGTACCAGTACCAATAT	0.378000													10	39					0	0	0.001368	0	0
UGT2B11	10720	broad.mit.edu	37	4	70080161	70080161	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:70080161C>A	ENST00000446444.1	-	1	288	c.280G>T	c.(280-282)Gtt>Ttt	p.V94F	RP11-704M14.1_ENST00000504301.1_RNA|RP11-704M14.1_ENST00000505646.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	94					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						CATCTCTTAACCTGTTGCATG	0.313000													48	118					4.64027e-19	1.08417e-18	0.003610	1	0
A1CF	29974	broad.mit.edu	37	10	52575947	52575947	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:52575947G>A	ENST00000395489.2	-	11	1335	c.939C>T	c.(937-939)ggC>ggT	p.G313G	ASAH2B_ENST00000483649.1_Intron|A1CF_ENST00000374001.1_Silent_p.G320G|A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000373995.3_Silent_p.G328G|A1CF_ENST00000373997.3_Silent_p.G320G|A1CF_ENST00000373993.1_Silent_p.G320G|A1CF_ENST00000395495.1_Silent_p.G265G|A1CF_ENST00000282641.2_Silent_p.G320G	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	320					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						GCAGCATGGTGCCCCTTCCAC	0.517000													12	53					0	0	0.000978	0	0
CNKSR3	154043	broad.mit.edu	37	6	154762449	154762449	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:154762449C>G	ENST00000607772.1	-	4	1028	c.484G>C	c.(484-486)Gac>Cac	p.D162H	CNKSR3_ENST00000479339.1_Missense_Mutation_p.D82H	NM_173515.2	NP_775786.2	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	162	CRIC.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	15		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		GTGGTCAGGTCCAAGCAAAGC	0.373000													35	76					0	0	0.003755	0	0
GP9	2815	broad.mit.edu	37	3	128780893	128780893	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:128780893C>G	ENST00000307395.4	+	3	533	c.311C>G	c.(310-312)aCg>aGg	p.T104R		NM_000174.3	NP_000165.1	P14770	GPIX_HUMAN	glycoprotein IX (platelet)	104	LRRCT.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding			NS(1)|central_nervous_system(1)|lung(4)	6					Quinine(DB00468)	GAGGACCGCACGCCCGAGGCC	0.692000													15	64					0	0	0.004007	0	0
IGSF9B	22997	broad.mit.edu	37	11	133794770	133794770	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:133794770G>T	ENST00000321016.8	-	15	2294	c.2064C>A	c.(2062-2064)gcC>gcA	p.A688A	IGSF9B_ENST00000533871.2_Silent_p.A688A			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	688	Fibronectin type-III 2.					integral to membrane|plasma membrane		p.A688A(1)|p.A144A(1)		breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCTGCATGACGGCCAGAACCC	0.577000													37	134					3.09479e-21	7.40314e-21	0.001485	1	0
TTN	7273	broad.mit.edu	37	2	179482516	179482516	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:179482516A>T	ENST00000589042.1	-	253	47786	c.47562T>A	c.(47560-47562)gcT>gcA	p.A15854A	TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342175.6_Silent_p.A6981A|TTN_ENST00000359218.5_Silent_p.A6914A|TTN_ENST00000591111.1_Silent_p.A14213A|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000460472.2_Silent_p.A6789A|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Silent_p.A13286A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14213	Fibronectin type-III 15.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAATTGGATCAGCAACTTTGA	0.388000													17	35					0	0	0.006122	0	0
ESR1	2099	broad.mit.edu	37	6	152382208	152382208	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:152382208C>T	ENST00000440973.1	+	8	1688	c.1318C>T	c.(1318-1320)Ctg>Ttg	p.L440L	ESR1_ENST00000406599.1_Silent_p.L179L|ESR1_ENST00000456483.2_Silent_p.L328L|ESR1_ENST00000443427.1_Silent_p.L440L|ESR1_ENST00000544394.1_Silent_p.L267L|ESR1_ENST00000338799.5_Silent_p.L440L|ESR1_ENST00000206249.3_Silent_p.L440L	NM_001122742.1	NP_001116214.1	P03372	ESR1_HUMAN	estrogen receptor 1	440	Interaction with AKAP13.|Steroid-binding.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(19)|ovary(1)|prostate(2)|skin(1)	49		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	CATGATGAATCTGCAGGGAGA	0.413000													13	15					0	0	0.003163	0	0
TLE3	7090	broad.mit.edu	37	15	70351092	70351092	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:70351092G>A	ENST00000558939.1	-	11	2205	c.828C>T	c.(826-828)gcC>gcT	p.A276A	TLE3_ENST00000559191.1_Intron|TLE3_ENST00000559929.1_Silent_p.A286A|TLE3_ENST00000539550.1_Silent_p.A220A|TLE3_ENST00000451782.2_Silent_p.A276A|TLE3_ENST00000560589.1_Silent_p.A220A|TLE3_ENST00000317509.8_Silent_p.A276A|TLE3_ENST00000557907.1_Silent_p.A276A|TLE3_ENST00000560939.1_Silent_p.A281A|TLE3_ENST00000440567.3_Silent_p.A269A|TLE3_ENST00000557997.1_Silent_p.A276A|TLE3_ENST00000442299.2_Silent_p.A276A|TLE3_ENST00000558379.1_Silent_p.A276A|TLE3_ENST00000559048.1_Silent_p.A281A|TLE3_ENST00000558201.1_Silent_p.A282A			Q04726	TLE3_HUMAN	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	276	Pro/Ser-rich.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding	p.A276A(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TCAGGCTACGGGCCTTGTCCA	0.582000													5	2					0	0	0.000602	0	0
RYR2	6262	broad.mit.edu	37	1	237608772	237608772	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:237608772C>A	ENST00000366574.2	+	14	1559	c.1242C>A	c.(1240-1242)cgC>cgA	p.R414R	RYR2_ENST00000360064.6_Silent_p.R412R|RYR2_ENST00000542537.1_Silent_p.R398R	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	414			R -> L (in CPVT1).		cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAGAATCACGCACAGCCCGAG	0.393000													25	109					2.21704e-12	4.48096e-12	0.002780	1	0
PTH2R	5746	broad.mit.edu	37	2	209308084	209308084	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:209308084G>A	ENST00000272847.2	+	6	734	c.521G>A	c.(520-522)tGc>tAc	p.C174Y	PTH2R_ENST00000413482.1_3'UTR	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor	174						integral to plasma membrane	parathyroid hormone receptor activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		CGATTGCATTGCACTAGGAAC	0.418000													17	20					0	0	0.006122	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182502	140182502	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140182502G>A	ENST00000522353.2	+	1	1720	c.1720G>A	c.(1720-1722)Ggt>Agt	p.G574S	PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.G574S|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGGCATCGGTGGCGCAGT	0.682000													44	86					0	0	0.002222	0	0
CRELD2	79174	broad.mit.edu	37	22	50315316	50315316	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:50315316C>A	ENST00000404488.3	+	5	634	c.499C>A	c.(499-501)Cgg>Agg	p.R167R	CRELD2_ENST00000444954.1_3'UTR|CRELD2_ENST00000403427.3_Silent_p.R167R|CRELD2_ENST00000328268.4_Silent_p.R167R|CRELD2_ENST00000407217.3_Silent_p.R167R	NM_001135101.1	NP_001128573.1	Q6UXH1	CREL2_HUMAN	cysteine-rich with EGF-like domains 2	167	EGF-like 1.					endoplasmic reticulum|extracellular region	calcium ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|stomach(3)	9		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.198)|LUAD - Lung adenocarcinoma(64;0.247)		CGGGTCCTGCCGGTGCCACAT	0.647000													29	102					1.75199e-13	3.64377e-13	0.001271	1	0
STK10	6793	broad.mit.edu	37	5	171523476	171523476	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:171523476T>A	ENST00000176763.5	-	8	1302	c.959A>T	c.(958-960)gAc>gTc	p.D320V		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	320							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATCCCGGCCGTCTTCGATCTC	0.642000													32	81					0	0	0.001786	0	0
TGFBI	7045	broad.mit.edu	37	5	135394834	135394834	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:135394834G>T	ENST00000442011.2	+	13	1895	c.1734G>T	c.(1732-1734)ctG>ctT	p.L578L	TGFBI_ENST00000508076.1_5'UTR|TGFBI_ENST00000305126.8_Silent_p.L578L	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	578	FAS1 4.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATGAAATCCTGGTTAGCGGAG	0.502000													10	18					5.16669e-11	1.02365e-10	0.000978	1	0
ZNF92	168374	broad.mit.edu	37	7	64863788	64863788	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:64863788A>G	ENST00000328747.7	+	4	960	c.761A>G	c.(760-762)gAg>gGg	p.E254G	ZNF92_ENST00000450302.2_Missense_Mutation_p.E185G|ZNF92_ENST00000431504.1_Missense_Mutation_p.E178G|ZNF92_ENST00000357512.2_Missense_Mutation_p.E222G	NM_152626.2	NP_689839.1	Q03936	ZNF92_HUMAN	zinc finger protein 92	254						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|skin(1)|stomach(1)	13		Lung NSC(55;0.159)				CATACTGGAGAGAAACCCTAC	0.348000													27	36					0	0	0.001271	0	0
RORB	6096	broad.mit.edu	37	9	77282809	77282809	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:77282809T>A	ENST00000376896.2	+	8	1715	c.1103T>A	c.(1102-1104)aTa>aAa	p.I368K	RORB_ENST00000396204.2_Missense_Mutation_p.I379K	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	379	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						GCTGTTCTGATATCTCCAGGT	0.413000													12	56					0	0	0.000978	0	0
PALM	5064	broad.mit.edu	37	19	746513	746513	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:746513C>A	ENST00000264560.7	+	8	925	c.731C>A	c.(730-732)cCg>cAg	p.P244Q	PALM_ENST00000606643.1_3'UTR|PALM_ENST00000338448.5_Missense_Mutation_p.P288Q	NM_001040134.1	NP_001035224.1	O75781	PALM_HUMAN	paralemmin	288					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane				endometrium(2)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		TCCGGCCCGCCGGGGATCCAG	0.697000													10	40					3.86212e-05	6.52464e-05	0.000673	1	0
WWC2	80014	broad.mit.edu	37	4	184186193	184186193	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:184186193G>T	ENST00000403733.3	+	12	2171	c.1972G>T	c.(1972-1974)Gtg>Ttg	p.V658L	WWC2_ENST00000378925.3_Missense_Mutation_p.V560L|WWC2_ENST00000448232.2_Missense_Mutation_p.V658L|WWC2_ENST00000513834.1_Missense_Mutation_p.V609L|WWC2_ENST00000504005.1_Missense_Mutation_p.V340L	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	658										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		AACCACTTGTGTGTCGGCTGC	0.483000													15	24					1.52009e-12	3.09414e-12	0.003163	1	0
PCDHB15	56121	broad.mit.edu	37	5	140625859	140625859	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140625859A>T	ENST00000231173.3	+	1	713	c.713A>T	c.(712-714)aAt>aTt	p.N238I		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		238	Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCAATGACAATGCCCCGGAG	0.577000													8	23					0	0	0.004482	0	0
LYZL2	119180	broad.mit.edu	37	10	30915774	30915774	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:30915774C>G	ENST00000375318.2	-	2	265	c.209G>C	c.(208-210)cGt>cCt	p.R70P		NM_183058.2	NP_898881.2	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	24					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			NS(2)|central_nervous_system(1)|large_intestine(1)|lung(14)|prostate(1)	19		Prostate(175;0.151)				CAGTTTGCAACGAGTGTAGAT	0.522000													27	49					0	0	0.001271	0	0
SEC16A	9919	broad.mit.edu	37	9	139353630	139353630	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:139353630C>G	ENST00000313050.7	-	15	5438	c.5365G>C	c.(5365-5367)Gcc>Ccc	p.A1789P	SEC16A_ENST00000371706.3_Missense_Mutation_p.A1611P|SEC16A_ENST00000431893.2_Missense_Mutation_p.A1611P|SEC16A_ENST00000290037.6_Missense_Mutation_p.A1611P	NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	1611	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		AGGGACTGGGCGTACTCATAG	0.522000													60	65					0	0	0.003610	0	0
NRXN1	9378	broad.mit.edu	37	2	51254722	51254722	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:51254722G>T	ENST00000404971.1	-	2	2029	c.690C>A	c.(688-690)aaC>aaA	p.N230K	NRXN1_ENST00000405472.3_Missense_Mutation_p.N230K|NRXN1_ENST00000402717.3_Missense_Mutation_p.N230K|NRXN1_ENST00000401669.2_Missense_Mutation_p.N230K|NRXN1_ENST00000405581.1_Missense_Mutation_p.N230K|NRXN1_ENST00000406316.2_Missense_Mutation_p.N230K|NRXN1_ENST00000406859.3_Missense_Mutation_p.N230K	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	230	EGF-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACACACCTCCGTTGAGGCACA	0.711000													11	15					4.68919e-08	8.65e-08	0.000673	1	0
ACAN	176	broad.mit.edu	37	15	89401765	89401765	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:89401765C>A	ENST00000439576.2	+	12	6323	c.5949C>A	c.(5947-5949)gaC>gaA	p.D1983E	ACAN_ENST00000352105.7_Missense_Mutation_p.D1983E|ACAN_ENST00000561243.1_Missense_Mutation_p.D1983E|ACAN_ENST00000559004.1_Missense_Mutation_p.D1983E	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1983					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GATTTCTGGACCTAAGTGGGC	0.542000													29	37					1.16021e-09	2.23683e-09	0.001271	1	0
SYTL2	54843	broad.mit.edu	37	11	85420476	85420476	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:85420476T>A	ENST00000359152.5	-	6	4435	c.4436A>T	c.(4435-4437)cAg>cTg	p.Q1479L	SYTL2_ENST00000389960.4_Missense_Mutation_p.Q609L|SYTL2_ENST00000533892.1_Missense_Mutation_p.Q35L|SYTL2_ENST00000529581.1_Missense_Mutation_p.Q75L|SYTL2_ENST00000525423.1_Missense_Mutation_p.Q955L|SYTL2_ENST00000528231.1_Missense_Mutation_p.Q633L|SYTL2_ENST00000527523.1_Missense_Mutation_p.Q601L|SYTL2_ENST00000524452.1_Missense_Mutation_p.Q609L|SYTL2_ENST00000354566.3_Missense_Mutation_p.Q971L|SYTL2_ENST00000525702.1_Missense_Mutation_p.Q75L|SYTL2_ENST00000316356.4_Missense_Mutation_p.Q634L|SYTL2_ENST00000389958.3_Missense_Mutation_p.Q64L	NM_206928.2	NP_996811.1	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	633					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		AATTGCAAACTGAATATTTCC	0.413000													25	65					0	0	0.002780	0	0
PXDN	7837	broad.mit.edu	37	2	1680770	1680770	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1680770C>T	ENST00000252804.4	-	8	827	c.777G>A	c.(775-777)tcG>tcA	p.S259S		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	259	Ig-like C2-type 1.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CGGTGTTCCCCGAGGTCACAT	0.532000													6	14					0	0	0.001984	0	0
VWA3A	146177	broad.mit.edu	37	16	22126703	22126703	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:22126703A>G	ENST00000389398.5	+	9	821	c.725A>G	c.(724-726)cAg>cGg	p.Q242R	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	242						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		AAGACGCTGCAGCCTGATGGA	0.463000													3	17					0	0	0.004672	0	0
KMT2D	8085	broad.mit.edu	37	12	49438025	49438025	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:49438025C>A	ENST00000301067.7	-	21	5145	c.5146G>T	c.(5146-5148)Gca>Tca	p.A1716S		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TCCGCCTGTGCAGCAGGCCCC	0.617000											OREG0021780	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	24					7.48243e-07	1.33843e-06	0.000443	1	0
HAVCR1	26762	broad.mit.edu	37	5	156479381	156479381	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:156479381G>T	ENST00000339252.3	-	3	1196	c.664C>A	c.(664-666)Cat>Aat	p.H222N	HAVCR1_ENST00000544197.1_Missense_Mutation_p.H222N|HAVCR1_ENST00000522693.1_Missense_Mutation_p.H222N|HAVCR1_ENST00000523175.1_Missense_Mutation_p.H222N|HAVCR1_ENST00000425854.1_Missense_Mutation_p.H222N	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	217					interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCTGGTTCATGGTTCTGCCTG	0.488000													50	138					4.18559e-23	1.02445e-22	0.003610	1	0
CACNB2	783	broad.mit.edu	37	10	18690910	18690910	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:18690910G>T	ENST00000396576.2	+	2	607	c.106G>T	c.(106-108)Gac>Tac	p.D36Y	CACNB2_ENST00000377328.1_Missense_Mutation_p.D91Y|CACNB2_ENST00000377329.4_Missense_Mutation_p.D37Y|CACNB2_ENST00000377331.2_Missense_Mutation_p.D63Y|CACNB2_ENST00000352115.6_Missense_Mutation_p.D91Y|CACNB2_ENST00000324631.7_Missense_Mutation_p.D91Y|CACNB2_ENST00000377315.4_Missense_Mutation_p.D43Y|CACNB2_ENST00000377319.3_Missense_Mutation_p.D36Y|CACNB2_ENST00000282343.8_Missense_Mutation_p.D63Y	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	91					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCTGGAGGAGGACCGGGAGGC	0.507000													11	56					2.80697e-09	5.32476e-09	0.000978	1	0
PEX1	5189	broad.mit.edu	37	7	92134134	92134134	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:92134134C>A	ENST00000248633.4	-	12	2078	c.1983G>T	c.(1981-1983)ctG>ctT	p.L661L	PEX1_ENST00000438045.1_Silent_p.L339L|PEX1_ENST00000428214.1_Intron|PEX1_ENST00000541751.1_Silent_p.L78L	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	661			Missing (in NALD).		microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CAAGGTCATCCAGCAGGACAA	0.502000													30	84					3.57733e-08	6.62334e-08	0.001786	1	0
LRRK2	120892	broad.mit.edu	37	12	40651127	40651127	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:40651127C>A	ENST00000298910.7	+	12	1424	c.1366C>A	c.(1366-1368)Cct>Act	p.P456T	LRRK2_ENST00000343742.2_Missense_Mutation_p.P456T	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	456					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TATACATTCTCCTGAAGTGGC	0.313000													30	59					3.73148e-12	7.51161e-12	0.001271	1	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													5	60					0	0	0.000602	0	0
BTBD11	121551	broad.mit.edu	37	12	108029160	108029160	+	Silent	SNP	G	G	C	rs149726114	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:108029160G>C	ENST00000280758.5	+	12	3258	c.2730G>C	c.(2728-2730)tcG>tcC	p.S910S	BTBD11_ENST00000420571.2_Silent_p.S791S|BTBD11_ENST00000357167.4_Silent_p.S447S|BTBD11_ENST00000494235.2_5'UTR|BTBD11_ENST00000490090.2_Silent_p.S910S	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	910						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AACAGACCTCGCGCTTGGGTG	0.552000													22	49					0	0	0.002299	0	0
SART3	9733	broad.mit.edu	37	12	108930562	108930562	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:108930562C>A	ENST00000228284.3	-	10	1544		c.e10-1		SART3_ENST00000431469.2_Splice_Site	NM_014706.3	NP_055521.1	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T cells 3						RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|stomach(1)	25						TTACTGGAGTCTAACGGAAAG	0.483000									Porokeratosis				12	22					2.80697e-09	5.32476e-09	0.000978	1	0
UBR4	23352	broad.mit.edu	37	1	19428082	19428082	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:19428082G>T	ENST00000375267.2	-	88	12958	c.12955C>A	c.(12955-12957)Cgc>Agc	p.R4319S	UBR4_ENST00000375254.3_Missense_Mutation_p.R4319S|UBR4_ENST00000375226.2_Missense_Mutation_p.R4295S|UBR4_ENST00000375217.2_Missense_Mutation_p.R4312S|UBR4_ENST00000375224.1_Missense_Mutation_p.R26S|UBR4_ENST00000543981.1_Missense_Mutation_p.R10S			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	4319					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AGATTGTAGCGCTTGGCTGTC	0.527000													37	79					2.87052e-16	6.37999e-16	0.005524	1	0
LAMP3	27074	broad.mit.edu	37	3	182841971	182841971	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:182841971C>A	ENST00000265598.3	-	6	1404	c.1149G>T	c.(1147-1149)gtG>gtT	p.V383V	LAMP3_ENST00000466939.1_Silent_p.V359V	NM_014398.3	NP_055213.2	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	383					cell proliferation	integral to membrane|lysosomal membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(2)	28	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			TCACAGGAAGCACAATTGTGT	0.463000													25	100					1.66031e-10	3.25096e-10	0.003954	1	0
SPG11	80208	broad.mit.edu	37	15	44888469	44888469	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:44888469A>G	ENST00000261866.7	-	25	4262	c.4246T>C	c.(4246-4248)Tcc>Ccc	p.S1416P	SPG11_ENST00000427534.2_Missense_Mutation_p.S1416P|SPG11_ENST00000558319.1_Missense_Mutation_p.S1416P|SPG11_ENST00000535302.2_Missense_Mutation_p.S1416P	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	1416					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TCCATTTTGGAGGTGGGCACT	0.463000													3	93					0	0	0.000248	0	0
NME8	51314	broad.mit.edu	37	7	37934211	37934211	+	Splice_Site	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:37934211G>C	ENST00000199447.4	+	16	1915	c.1544_splice	c.e16+1	p.V515_splice	NME8_ENST00000440017.1_Splice_Site_p.V515_splice|EPDR1_ENST00000476620.1_Intron	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	515	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										AATGTTATCTGTGTAAGTTTC	0.254000													5	13					0	0	0.000602	0	0
RINT1	60561	broad.mit.edu	37	7	105204333	105204333	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:105204333C>T	ENST00000257700.2	+	12	2056	c.1825C>T	c.(1825-1827)Cgt>Tgt	p.R609C		NM_021930.4	NP_068749.3	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	609	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						TATGTTGACCCGTCAAGTAGA	0.383000													12	43					0	0	0.000978	0	0
CTNNA2	1496	broad.mit.edu	37	2	80136847	80136847	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:80136847G>T	ENST00000466387.1	+	11	1704	c.980G>T	c.(979-981)cGg>cTg	p.R327L	CTNNA2_ENST00000402739.4_Missense_Mutation_p.R327L|CTNNA2_ENST00000540488.1_Missense_Mutation_p.R327L|CTNNA2_ENST00000496558.1_Missense_Mutation_p.R327L|CTNNA2_ENST00000361291.4_Missense_Mutation_p.R361L|CTNNA2_ENST00000541047.1_Missense_Mutation_p.R327L			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	327					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CGAGACGACCGGCGCGAGAGG	0.637000													33	74					5.8336e-16	1.29228e-15	0.003271	1	0
NGF	4803	broad.mit.edu	37	1	115828838	115828838	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:115828838G>A	ENST00000369512.2	-	3	747	c.579C>T	c.(577-579)gaC>gaT	p.D193D	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	193					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	AGTGCTTTGAGTCAATGCCCC	0.507000													23	50					0	0	0.001882	0	0
MUC16	94025	broad.mit.edu	37	19	9075894	9075894	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9075894T>A	ENST00000397910.4	-	3	11755	c.11552A>T	c.(11551-11553)cAg>cTg	p.Q3851L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3852	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCCTTGTCTCTGAAAAGTTGC	0.502000													34	67					0	0	0.002096	0	0
ABCD4	5826	broad.mit.edu	37	14	74759551	74759551	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:74759551T>C	ENST00000356924.4	-	9	979	c.836A>G	c.(835-837)tAt>tGt	p.Y279C	AC005519.4_ENST00000554532.2_RNA|ABCD4_ENST00000298816.7_Missense_Mutation_p.Y175C|ABCD4_ENST00000557588.1_3'UTR|ABCD4_ENST00000557554.1_Intron	NM_005050.3	NP_005041.1	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D (ALD), member 4	279	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			cervix(2)|endometrium(3)|kidney(3)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00153)		GCTGCCCAGATAGTCAAAGGT	0.537000													22	47					0	0	0.003330	0	0
RBMY2EP	159125	broad.mit.edu	37	Y	23557115	23557115	+	RNA	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:23557115G>T	ENST00000444169.1	-	0	452					NR_001574.2																						TTATAATCAGGGTGGCTGCTT	0.453000													22	7					1.10923e-09	2.1406e-09	0.002780	1	0
TMEM132D	121256	broad.mit.edu	37	12	130184929	130184929	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:130184929G>T	ENST00000422113.2	-	2	720	c.394C>A	c.(394-396)Cac>Aac	p.H132N		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	132						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CGCAGGATGTGGGCTTTTAGT	0.527000													14	30					1.3612e-06	2.40699e-06	0.003163	1	0
SERAC1	84947	broad.mit.edu	37	6	158569896	158569896	+	Splice_Site	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:158569896C>G	ENST00000367102.2	-	5	497		c.e5+1		SERAC1_ENST00000607000.1_Splice_Site|SERAC1_ENST00000367104.3_Splice_Site|SERAC1_ENST00000367101.1_Splice_Site			Q96JX3	SRAC1_HUMAN	serine active site containing 1						GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds			endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	15		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		TGGATATTTACCAGCAAATGG	0.338000													9	29					0	0	0.000443	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167951	140167951	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140167951G>A	ENST00000504120.2	+	1	2076	c.2076G>A	c.(2074-2076)gcG>gcA	p.A692A	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000378133.3_Silent_p.A692A	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAGGCGGCGCTGGTGGATG	0.662000													24	67					0	0	0.003330	0	0
WNK2	65268	broad.mit.edu	37	9	96025977	96025977	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:96025977G>T	ENST00000297954.4	+	14	3540	c.3540G>T	c.(3538-3540)cgG>cgT	p.R1180R	WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000395477.2_Silent_p.R1180R|WNK2_ENST00000349097.3_Silent_p.R792R|WNK2_ENST00000427277.2_Silent_p.R792R|WNK2_ENST00000395475.2_3'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1180					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CGCGCTCCCGGCAGGAGAGGG	0.706000													6	9					5.9392e-07	1.06523e-06	0.001168	1	0
KHDRBS2	202559	broad.mit.edu	37	6	62390894	62390894	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:62390894T>C	ENST00000281156.4	-	9	1302	c.1024A>G	c.(1024-1026)Agg>Ggg	p.R342G	RP1-240B8.3_ENST00000511849.2_RNA	NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		GGGTGTTCCCTGTATCCCCCT	0.498000													17	32					0	0	0.000958	0	0
AVPR1A	552	broad.mit.edu	37	12	63543951	63543951	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:63543951G>T	ENST00000299178.2	-	1	771	c.666C>A	c.(664-666)ggC>ggA	p.G222G		NM_000706.4	NP_000697.1	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	222					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|prostate(2)|skin(1)	26			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	CAAAGATGCCGCCCGTCATCC	0.612000													34	93					3.90053e-15	8.46309e-15	0.002445	1	0
HERPUD2	64224	broad.mit.edu	37	7	35673920	35673920	+	Splice_Site	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:35673920A>G	ENST00000396081.1	-	7	1864		c.e7+1		HERPUD2_ENST00000311350.3_Splice_Site	NM_022373.4	NP_071768.3	Q9BSE4	HERP2_HUMAN	HERPUD family member 2						response to unfolded protein	integral to membrane				kidney(3)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)	18						TCAATCACATACCATTTCTTC	0.393000													12	34					0	0	0.001855	0	0
LAMC3	10319	broad.mit.edu	37	9	133946978	133946978	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:133946978G>A	ENST00000361069.4	+	18	3310	c.3177G>A	c.(3175-3177)agG>agA	p.R1059R	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	1059	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		AGGCCCCAAGGGGGGACGTCT	0.657000													26	38					0	0	0.003330	0	0
MUC16	94025	broad.mit.edu	37	19	9071927	9071927	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9071927A>G	ENST00000397910.4	-	3	15722	c.15519T>C	c.(15517-15519)ggT>ggC	p.G5173G		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5175	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTCAGAGGAACCATGCACTG	0.498000													70	242					0	0	0.003610	0	0
TDRD5	163589	broad.mit.edu	37	1	179632540	179632540	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:179632540C>T	ENST00000444136.1	+	16	2813	c.2563C>T	c.(2563-2565)Ctt>Ttt	p.L855F	TDRD5_ENST00000294848.8_Missense_Mutation_p.L801F|TDRD5_ENST00000367614.1_Missense_Mutation_p.L801F	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	832					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						GCCTTCAGGCCTTGTAAATGG	0.398000													16	45					0	0	0.003163	0	0
FAS	355	broad.mit.edu	37	10	90762893	90762893	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:90762893T>A	ENST00000355740.2	+	2	358	c.138T>A	c.(136-138)acT>acA	p.T46T	FAS_ENST00000313771.5_3'UTR|FAS_ENST00000357339.2_Silent_p.T46T|FAS_ENST00000355279.2_Silent_p.T46T|FAS_ENST00000352159.4_Silent_p.T46T	NM_000043.4|NM_152871.2|NM_152872.2	NP_000034.1|NP_690610.1|NP_690611.1	P25445	TNR6_HUMAN	Fas cell surface death receptor	46					activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			breast(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		CAGTTGAGACTCAGAACTTGG	0.443000													27	64					0	0	0.005443	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101627047	101627047	+	Splice_Site	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:101627047C>T	ENST00000310954.6	-	2	905	c.619_splice	c.e2+1	p.D207_splice		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	207					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		AGAAACTTACCTTCAAAAAGA	0.348000													17	45					0	0	0.004990	0	0
NETO1	81832	broad.mit.edu	37	18	70417315	70417315	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:70417315T>A	ENST00000327305.6	-	9	2180	c.1523A>T	c.(1522-1524)cAc>cTc	p.H508L	NETO1_ENST00000299430.2_Missense_Mutation_p.H507L|NETO1_ENST00000583169.1_Missense_Mutation_p.H508L	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	508					memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GGCTTTATCGTGTCTGGACAG	0.438000													26	25					0	0	0.005443	0	0
NKAPL	222698	broad.mit.edu	37	6	28228212	28228212	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:28228212C>T	ENST00000343684.3	+	1	1115	c.1063C>T	c.(1063-1065)Cgt>Tgt	p.R355C		NM_001007531.1	NP_001007532.1	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	355										breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31						TGTACGACTGCGTAAGGAGAA	0.443000													27	174					0	0	0.004656	0	0
RGS9	8787	broad.mit.edu	37	17	63206682	63206682	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:63206682G>T	ENST00000449996.3	+	17	1429	c.1357G>T	c.(1357-1359)Gcc>Tcc	p.A453S	RGS9_ENST00000262406.9_Missense_Mutation_p.A456S|RGS9_ENST00000443584.3_Missense_Mutation_p.A453S	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	456					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						GGAAGAGGAAGCCAAGGCCCG	0.567000													28	69					1.5548e-18	3.57444e-18	0.005443	1	0
ZNF789	285989	broad.mit.edu	37	7	99084446	99084446	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:99084446G>C	ENST00000331410.5	+	5	883	c.613G>C	c.(613-615)Gaa>Caa	p.E205Q	ZNF789_ENST00000494186.1_Intron|ZNF789_ENST00000493485.1_Intron	NM_213603.2	NP_998768.2	Q5FWF6	ZN789_HUMAN	zinc finger protein 789	205					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)	11	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGAATGCAGTGAATGTGGAAA	0.418000													34	55					0	0	0.003271	0	0
FAM83F	113828	broad.mit.edu	37	22	40417675	40417675	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:40417675C>T	ENST00000333407.5	+	4	1255	c.1161C>T	c.(1159-1161)ccC>ccT	p.P387P	FAM83F_ENST00000473717.1_3'UTR	NM_138435.2	NP_612444.2	Q8NEG4	FA83F_HUMAN	family with sequence similarity 83, member F	387										breast(1)|endometrium(2)|large_intestine(1)|lung(4)|skin(4)|urinary_tract(2)	14						TGCTGCCCCCCGTGGAGCCCA	0.662000													13	48					0	0	0.003163	0	0
CEP104	9731	broad.mit.edu	37	1	3754057	3754057	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:3754057G>C	ENST00000378230.3	-	9	1242	c.918C>G	c.(916-918)ctC>ctG	p.L306L		NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	306						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						CGAGGGGCTGGAGGGGCAAAT	0.458000													22	27					0	0	0.002780	0	0
PCSK2	5126	broad.mit.edu	37	20	17446125	17446125	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:17446125G>A	ENST00000262545.2	+	11	1672	c.1357G>A	c.(1357-1359)Gtg>Atg	p.V453M	PCSK2_ENST00000377899.1_Missense_Mutation_p.V434M|PCSK2_ENST00000459871.1_3'UTR|PCSK2_ENST00000536609.1_Missense_Mutation_p.V418M	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	453					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGGTGCCATGGTGAAAATGGC	0.567000													10	20					0	0	0.000443	0	0
RET	5979	broad.mit.edu	37	10	43595965	43595965	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:43595965G>T	ENST00000355710.3	+	2	364	c.132G>T	c.(130-132)caG>caT	p.Q44H	RET_ENST00000340058.5_Missense_Mutation_p.Q44H	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	44					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	ATGTGGACCAGGCAGCCGGCA	0.612000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				19	41					7.21436e-19	1.67778e-18	0.001216	1	0
CCT8L2	150160	broad.mit.edu	37	22	17072618	17072618	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:17072618C>G	ENST00000359963.3	-	1	1082	c.823G>C	c.(823-825)Gat>Cat	p.D275H		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	275					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AGTAATTGATCGCTTCCTTTA	0.527000													49	141					0	0	0.003610	0	0
KCNV1	27012	broad.mit.edu	37	8	110980754	110980754	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:110980754C>A	ENST00000524391.1	-	4	2098	c.1066G>T	c.(1066-1068)Gga>Tga	p.G356*	KCNV1_ENST00000297404.1_Nonsense_Mutation_p.G356*			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	356						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			ATAGAGATTCCCACGGATAGA	0.478000													35	53					2.80507e-11	5.5962e-11	0.002445	1	0
RXRG	6258	broad.mit.edu	37	1	165377464	165377464	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:165377464C>A	ENST00000359842.5	-	8	1440	c.1138_splice	c.e8+1	p.D380_splice		NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	380	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GGGCGGTTACCTGGGTTAAAG	0.512000													34	66					2.05212e-20	4.86832e-20	0.005524	1	0
AHNAK	79026	broad.mit.edu	37	11	62298691	62298691	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:62298691C>G	ENST00000378024.4	-	5	3472	c.3198G>C	c.(3196-3198)aaG>aaC	p.K1066N	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1066					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GCAAAGACATCTTAGGAGCTC	0.443000													23	106					0	0	0.001882	0	0
NAV2	89797	broad.mit.edu	37	11	20065574	20065574	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:20065574T>C	ENST00000396085.1	+	13	3316	c.2955T>C	c.(2953-2955)tcT>tcC	p.S985S	NAV2_ENST00000540292.1_Silent_p.S939S|NAV2_ENST00000533917.1_Silent_p.S71S|NAV2-AS2_ENST00000533767.1_RNA|NAV2_ENST00000311043.8_Silent_p.S71S|NAV2_ENST00000396087.3_Silent_p.S1008S|NAV2_ENST00000360655.4_Silent_p.S921S|NAV2_ENST00000349880.4_Silent_p.S985S|NAV2_ENST00000527559.2_Silent_p.S937S	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1008						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						CCCTGTGGTCTGGTGATGATG	0.527000													24	64					0	0	0.003954	0	0
FAM134C	162427	broad.mit.edu	37	17	40734205	40734205	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:40734205G>C	ENST00000309428.5	-	9	1086	c.1027C>G	c.(1027-1029)Ctg>Gtg	p.L343V	FAM134C_ENST00000585894.1_Missense_Mutation_p.L246V|FAM134C_ENST00000543197.1_Missense_Mutation_p.L148V	NM_178126.3	NP_835227.1	Q86VR2	F134C_HUMAN	family with sequence similarity 134, member C	343						integral to membrane				endometrium(1)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	11		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		TCATCATCCAGGCCAGCAGGA	0.567000													39	90					0	0	0.004878	0	0
USP15	9958	broad.mit.edu	37	12	62715352	62715352	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:62715352G>T	ENST00000280377.5	+	5	641	c.583G>T	c.(583-585)Gac>Tac	p.D195Y	USP15_ENST00000353364.3_Missense_Mutation_p.D195Y|USP15_ENST00000393654.3_Missense_Mutation_p.D195Y|USP15_ENST00000550632.1_3'UTR|USP15_ENST00000312635.6_Missense_Mutation_p.D195Y	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	195					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		GAATAAACCAGACAGCACCAT	0.333000													7	29					0.000274275	0.000453435	0.004482	1	0
PCDH17	27253	broad.mit.edu	37	13	58208274	58208274	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:58208274G>T	ENST00000377918.3	+	1	1620	c.1594G>T	c.(1594-1596)Ggg>Tgg	p.G532W		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	532	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TCCCACGAACGGGGCCATCTA	0.587000													13	17					0.000151284	0.000252392	0.001855	1	0
TMEM8A	58986	broad.mit.edu	37	16	422106	422106	+	Missense_Mutation	SNP	C	C	G	rs150493488		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:422106C>G	ENST00000431232.2	-	13	2357	c.2197G>C	c.(2197-2199)Gca>Cca	p.A733P	TMEM8A_ENST00000250930.3_Missense_Mutation_p.A540P	NM_021259.2	NP_067082.2	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8A	733					cell adhesion	integral to plasma membrane				central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	14						AGCAAGGCTGCGCTCCCGGCC	0.607000													55	62					0	0	0.003610	0	0
HYAL4	23553	broad.mit.edu	37	7	123508735	123508735	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:123508735A>G	ENST00000223026.4	+	3	1046	c.408A>G	c.(406-408)gaA>gaG	p.E136E	HYAL4_ENST00000476325.1_Silent_p.E136E	NM_012269.2	NP_036401.2	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	136					fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	23						TCCCTGCTGAAGATTTCAGTG	0.428000													19	63					0	0	0.001216	0	0
SYTL2	54843	broad.mit.edu	37	11	85436429	85436429	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:85436429C>A	ENST00000359152.5	-	1	2642	c.2643G>T	c.(2641-2643)gtG>gtT	p.V881V	SYTL2_ENST00000389960.4_Intron|SYTL2_ENST00000525423.1_Silent_p.V357V|SYTL2_ENST00000528231.1_Intron|SYTL2_ENST00000527523.1_Intron|SYTL2_ENST00000524452.1_Intron|SYTL2_ENST00000354566.3_Silent_p.V357V|SYTL2_ENST00000316356.4_Intron	NM_206928.2	NP_996811.1	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	0					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		GAGGGCTGGCCACATCCCCAA	0.493000													14	36					9.31168e-06	1.61108e-05	0.001855	1	0
C9	735	broad.mit.edu	37	5	39289035	39289035	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:39289035G>C	ENST00000263408.4	-	10	1530	c.1435C>G	c.(1435-1437)Ctg>Gtg	p.L479V		NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	479	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			ACTGGAACCAGATTATATATA	0.313000													20	40					0	0	0.001523	0	0
MAP3K19	80122	broad.mit.edu	37	2	135740765	135740765	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:135740765A>T	ENST00000392915.1	-	9	3529	c.3410T>A	c.(3409-3411)gTg>gAg	p.V1137E	MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000358371.4_Intron|MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000375845.3_Intron|MAP3K19_ENST00000315513.3_5'UTR					mitogen-activated protein kinase kinase kinase 19																		ttcatcgcccaccccCCAAGA	0.378000													36	37					0	0	0.003755	0	0
ESYT3	83850	broad.mit.edu	37	3	138174129	138174129	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:138174129C>A	ENST00000389567.4	+	3	649	c.463C>A	c.(463-465)Ctg>Atg	p.L155M	ESYT3_ENST00000289135.4_Missense_Mutation_p.L155M	NM_031913.3	NP_114119.2	A0FGR9	ESYT3_HUMAN	extended synaptotagmin-like protein 3	155						integral to membrane|plasma membrane		p.L155L(1)		breast(1)|endometrium(5)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	25						GAGCATCCACCTGAGGACCTT	0.522000													19	105					1.15919e-05	1.99698e-05	0.001216	1	0
BRINP1	1620	broad.mit.edu	37	9	122075568	122075568	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:122075568G>A	ENST00000265922.3	-	2	527	c.66C>T	c.(64-66)ccC>ccT	p.P22P	DBC1_ENST00000373964.2_Silent_p.P22P	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		22					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						CCTGGTGGGAGGGCTGCACTG	0.512000													43	54					0	0	0.003610	0	0
KDM4B	23030	broad.mit.edu	37	19	5082396	5082396	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:5082396G>T	ENST00000159111.4	+	9	1017	c.799G>T	c.(799-801)Gaa>Taa	p.E267*	KDM4B_ENST00000536461.1_Nonsense_Mutation_p.E267*|KDM4B_ENST00000381759.4_Nonsense_Mutation_p.E267*|KDM4B_ENST00000592175.1_3'UTR	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	267	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						GGAGGCCGGGGAATTCATGAT	0.597000													11	23					9.70103e-10	1.87572e-09	0.000673	1	0
OR1S2	219958	broad.mit.edu	37	11	57970690	57970690	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:57970690T>C	ENST00000302592.6	-	1	963	c.964A>G	c.(964-966)Att>Gtt	p.I322V		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	322					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				AGGGAAGAAATTTTTCTATTG	0.418000													55	97					0	0	0.003610	0	0
DNAH2	146754	broad.mit.edu	37	17	7689567	7689567	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:7689567C>T	ENST00000572933.1	+	40	7715	c.6255C>T	c.(6253-6255)tgC>tgT	p.C2085C	DNAH2_ENST00000389173.2_Silent_p.C2085C			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2085	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCGTGGGCTGCACGGGCAGCG	0.577000													19	54					0	0	0.005443	0	0
SGCZ	137868	broad.mit.edu	37	8	13959967	13959967	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:13959967C>A	ENST00000382080.1	-	7	1377	c.662G>T	c.(661-663)cGt>cTt	p.R221L	SGCZ_ENST00000421524.2_Missense_Mutation_p.R174L	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	208					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CTGGACCCCACGGGGAGCTTC	0.458000													16	44					2.31682e-05	3.9439e-05	0.003163	1	0
CEP350	9857	broad.mit.edu	37	1	180061771	180061771	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:180061771G>C	ENST00000367607.3	+	34	6949	c.6531G>C	c.(6529-6531)gaG>gaC	p.E2177D	CEP350_ENST00000490141.1_3'UTR	NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	2177						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						CTGGTTCTGAGAGATCAGTAT	0.348000													8	16					0	0	0.003080	0	0
CPT1A	1374	broad.mit.edu	37	11	68571469	68571469	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:68571469C>A	ENST00000265641.5	-	5	708	c.555_splice	c.e5+1	p.R185_splice	CPT1A_ENST00000539743.1_Splice_Site_p.R185_splice|CPT1A_ENST00000540367.1_Splice_Site_p.R185_splice|CPT1A_ENST00000376618.2_Splice_Site_p.R185_splice	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	185					carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	CACACCTACCCTGTTCACAGT	0.512000													21	44					3.8784e-16	8.61057e-16	0.001882	1	0
WBSCR17	64409	broad.mit.edu	37	7	71036356	71036356	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:71036356A>G	ENST00000333538.5	+	6	1683	c.1049A>G	c.(1048-1050)tAc>tGc	p.Y350C	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	350	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				ATGGATGTATACGGAGGAGAA	0.512000													29	76					0	0	0.002445	0	0
ACO2	50	broad.mit.edu	37	22	41918884	41918884	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:41918884G>T	ENST00000396512.3	+	10	1281	c.1264G>T	c.(1264-1266)Gca>Tca	p.A422S	ACO2_ENST00000216254.4_Missense_Mutation_p.A397S			Q99798	ACON_HUMAN	aconitase 2, mitochondrial	397					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(3)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	23						GGGGCGCTCAGCAGCTGTGGC	0.572000													22	49					5.26018e-13	1.08057e-12	0.001882	1	0
VCP	7415	broad.mit.edu	37	9	35061050	35061050	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35061050C>A	ENST00000358901.6	-	11	2216	c.1321G>T	c.(1321-1323)Gtc>Ttc	p.V441F		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	441					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GAGTTCATGACCTCGGCATCA	0.527000													54	181					1.54886e-18	3.57306e-18	0.003610	1	0
RPL23	9349	broad.mit.edu	37	17	37009953	37009953	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:37009953C>G	ENST00000479035.2	-	1	143	c.11G>C	c.(10-12)cGa>cCa	p.R4P	RPL23_ENST00000394332.1_Missense_Mutation_p.R4P|RPL23_ENST00000394333.1_Missense_Mutation_p.R4P|RPL23_ENST00000577407.1_Missense_Mutation_p.R4P	NM_000978.3	NP_000969.1	P62829	RL23_HUMAN	ribosomal protein L23	4					endocrine pancreas development|ribosomal protein import into nucleus|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome			endometrium(2)|large_intestine(1)	3						AACCTCACCTCGCTTCGACAT	0.562000													5	26					0	0	0.001984	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167848	140167848	+	Missense_Mutation	SNP	C	C	G	rs149133665		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140167848C>G	ENST00000504120.2	+	1	1973	c.1973C>G	c.(1972-1974)gCg>gGg	p.A658G	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000378133.3_Missense_Mutation_p.A658G	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGAGCCGGCGCTGACAGCC	0.667000													19	81					0	0	0.000958	0	0
SLC6A15	55117	broad.mit.edu	37	12	85255711	85255711	+	Silent	SNP	G	G	T	rs149254147		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:85255711G>T	ENST00000266682.5	-	12	2434	c.1893C>A	c.(1891-1893)ctC>ctA	p.L631L	SLC6A15_ENST00000309283.7_Intron|SLC6A15_ENST00000552192.1_Silent_p.L524L	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	631					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						CAGGGACTGGGAGTATTGCAA	0.393000													19	88					3.57192e-18	8.15569e-18	0.006122	1	0
FRMPD2	143162	broad.mit.edu	37	10	49431169	49431169	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:49431169A>T	ENST00000374201.3	-	11	1615	c.1313T>A	c.(1312-1314)cTc>cAc	p.L438H	FRMPD2_ENST00000305531.3_Missense_Mutation_p.L414H|FRMPD2_ENST00000407470.4_Missense_Mutation_p.L407H	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	438	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		CACTCACTGGAGCAGCCCATA	0.473000													30	59					0	0	0.001512	0	0
CDC42EP2	10435	broad.mit.edu	37	11	65088571	65088571	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:65088571A>G	ENST00000544348.1	+	2	808	c.202A>G	c.(202-204)Acc>Gcc	p.T68A	CDC42EP2_ENST00000279249.2_Missense_Mutation_p.T68A|CDC42EP2_ENST00000533419.1_Missense_Mutation_p.T68A			O14613	BORG1_HUMAN	CDC42 effector protein (Rho GTPase binding) 2	68					actin filament organization|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|regulation of cell shape	cytoplasm|cytoskeleton|endomembrane system|plasma membrane	GTP-Rho binding|Rho GTPase activator activity			lung(1)	1						CCTGCCGGGGACCATGGTGGA	0.647000													24	54					0	0	0.003954	0	0
TINAG	27283	broad.mit.edu	37	6	54173485	54173485	+	Missense_Mutation	SNP	G	G	T	rs147898099		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:54173485G>T	ENST00000259782.4	+	1	233	c.137G>T	c.(136-138)cGa>cTa	p.R46L	TINAG_ENST00000370864.3_Missense_Mutation_p.R28L|TINAG_ENST00000370869.3_Missense_Mutation_p.R42L|TINAG_ENST00000486436.1_3'UTR	NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	46					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			CAAGGTACTCGATTCAAAAGA	0.428000													33	165					1.45844e-13	3.03954e-13	0.002836	1	0
ROBO2	6092	broad.mit.edu	37	3	75986715	75986715	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:75986715T>C	ENST00000487694.3	+	2	350	c.71T>C	c.(70-72)gTg>gCg	p.V24A		NM_001128929.2	NP_001122401.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	0					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ATGATGACTGTGGTGTTTTGG	0.453000													4	14					0	0	0.000248	0	0
MYH2	4620	broad.mit.edu	37	17	10428788	10428788	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10428788C>T	ENST00000245503.5	-	32	4901	c.4517G>A	c.(4516-4518)cGa>cAa	p.R1506Q	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron|MYH2_ENST00000397183.2_Missense_Mutation_p.R1506Q	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1506					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.R1506Q(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTTGTTCTCTCGCTTCAGGGT	0.428000													27	74					0	0	0.005443	0	0
TTN	7273	broad.mit.edu	37	2	179457788	179457788	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:179457788A>T	ENST00000589042.1	-	300	59282	c.59058T>A	c.(59056-59058)aaT>aaA	p.N19686K	TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.N10813K|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.N10746K|TTN_ENST00000591111.1_Missense_Mutation_p.N18045K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.N10621K|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.N17118K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18045	Fibronectin type-III 42.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGCTTCAGGATTAACAGGTG	0.358000													45	52					0	0	0.002222	0	0
NUP214	8021	broad.mit.edu	37	9	134021593	134021593	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:134021593C>A	ENST00000359428.5	+	13	1991	c.1847C>A	c.(1846-1848)tCc>tAc	p.S616Y	RP11-544A12.4_ENST00000589667.1_RNA|RP11-544A12.4_ENST00000415391.2_RNA|RP11-544A12.4_ENST00000586290.1_RNA|RP11-544A12.4_ENST00000588378.1_RNA|RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000587408.1_RNA|RP11-544A12.4_ENST00000589540.1_RNA|NUP214_ENST00000411637.2_Missense_Mutation_p.S605Y|NUP214_ENST00000451030.1_Missense_Mutation_p.S616Y|RP11-544A12.4_ENST00000590461.1_RNA			P35658	NU214_HUMAN	nucleoporin 214kDa	616	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TCTTCTGCCTCCAAGCCAGCT	0.567000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								231	318					1.95565e-89	5.09739e-89	0.003610	1	0
TCAIM	285343	broad.mit.edu	37	3	44441904	44441904	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:44441904G>T	ENST00000342649.4	+	9	1370	c.943G>T	c.(943-945)Gac>Tac	p.D315Y	TCAIM_ENST00000417237.1_Missense_Mutation_p.D315Y	NM_173826.3	NP_776187.2			T cell activation inhibitor, mitochondrial																		GATTTTAGAAGACCAAATAAG	0.318000													11	25					1.58986e-06	2.799e-06	0.000673	1	0
DNAI2	64446	broad.mit.edu	37	17	72301505	72301505	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:72301505A>T	ENST00000579490.1	+	8	1441	c.1306A>T	c.(1306-1308)Aac>Tac	p.N436Y	DNAI2_ENST00000582036.1_Missense_Mutation_p.N379Y|DNAI2_ENST00000307504.5_Missense_Mutation_p.N236Y|DNAI2_ENST00000311014.6_Missense_Mutation_p.N379Y|DNAI2_ENST00000446837.2_Missense_Mutation_p.N379Y			Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate chain 2	379					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CTACCCGAAGAACTTCCTGAC	0.577000									Kartagener syndrome				34	36					0	0	0.002096	0	0
TMBIM4	51643	broad.mit.edu	37	12	66531826	66531826	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:66531826C>T	ENST00000358230.3	-	7	751	c.631G>A	c.(631-633)Gta>Ata	p.V211I	TMBIM4_ENST00000544599.1_Missense_Mutation_p.V34I|TMBIM4_ENST00000556010.1_3'UTR|TMBIM4_ENST00000539652.1_3'UTR|TMBIM4_ENST00000542724.1_Missense_Mutation_p.V180I|TMBIM4_ENST00000286424.7_Missense_Mutation_p.V258I|TMBIM4_ENST00000398033.4_3'UTR	NM_016056.2	NP_057140.2	Q9HC24	TMBI4_HUMAN	transmembrane BAX inhibitor motif containing 4	211						integral to membrane	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|ovary(1)|prostate(2)	9				GBM - Glioblastoma multiforme(28;0.0745)		GCAGCTAATACGTACTCTTCA	0.413000													22	47					0	0	0.003330	0	0
POLE	5426	broad.mit.edu	37	12	133234500	133234500	+	Missense_Mutation	SNP	C	C	T	rs114315196	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133234500C>T	ENST00000320574.5	-	27	3375	c.3332G>A	c.(3331-3333)cGg>cAg	p.R1111Q	POLE_ENST00000535270.1_Missense_Mutation_p.R1084Q	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1111					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GAGCCATTTCCGGAGAAAGTG	0.483000								DNA polymerases (catalytic subunits)					34	84					0	0	0.004878	0	0
SH3TC2	79628	broad.mit.edu	37	5	148407063	148407063	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:148407063C>A	ENST00000538184.1	-	7	1761	c.873G>T	c.(871-873)ctG>ctT	p.L291L	SH3TC2_ENST00000394358.2_Silent_p.L629L|SH3TC2_ENST00000515425.1_Silent_p.L744L|SH3TC2_ENST00000512049.1_Silent_p.L737L			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	744	SH3.						binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAGGCAGCCAGGGCCTGTC	0.592000													21	40					3.51602e-12	7.08498e-12	0.001216	1	0
OR11H6	122748	broad.mit.edu	37	14	20692320	20692320	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20692320C>A	ENST00000315519.2	+	1	530	c.452C>A	c.(451-453)cCc>cAc	p.P151H		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TTACACTACCCCTCCATCATG	0.423000													40	77					5.71845e-15	1.23541e-14	0.005524	1	0
SPRY4	81848	broad.mit.edu	37	5	141693814	141693814	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:141693814C>A	ENST00000344120.4	-	3	1115	c.929G>T	c.(928-930)aGc>aTc	p.S310I	SPRY4_ENST00000434127.2_Missense_Mutation_p.S287I	NM_030964.3	NP_112226.2	Q9C004	SPY4_HUMAN	sprouty homolog 4 (Drosophila)	287					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(7)|ovary(1)	18		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCATCCCCGCTGGCTGCTTT	0.617000									Testicular Cancer, Familial Clustering of				12	33					0.00136819	0.0022416	0.001368	1	0
OR2G3	81469	broad.mit.edu	37	1	247769112	247769112	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247769112T>C	ENST00000320002.2	+	1	257	c.225T>C	c.(223-225)acT>acC	p.T75T	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GCTTCACTACTAGCCTTGCTC	0.448000													178	207					0	0	0.003610	0	0
LRRC7	57554	broad.mit.edu	37	1	70493932	70493932	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:70493932G>A	ENST00000310961.5	+	19	2192	c.1774G>A	c.(1774-1776)Gtg>Atg	p.V592M	RP11-181B18.1_ENST00000414132.1_RNA|LRRC7_ENST00000035383.5_Missense_Mutation_p.V587M|LRRC7_ENST00000415775.2_Intron			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	587						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TCAAAATTTGGTGGGTAAGCC	0.378000													17	54					0	0	0.004007	0	0
CD93	22918	broad.mit.edu	37	20	23064994	23064994	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23064994C>G	ENST00000246006.4	-	1	1983	c.1836G>C	c.(1834-1836)aaG>aaC	p.K612N		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	612					cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TCTCCTCCCTCTTCGCTCTCC	0.567000													52	149					0	0	0.003610	0	0
EIF4EBP1	1978	broad.mit.edu	37	8	37914654	37914654	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:37914654G>T	ENST00000338825.4	+	2	434	c.201G>T	c.(199-201)gtG>gtT	p.V67V	EIF4EBP1_ENST00000520657.1_3'UTR	NM_004095.3	NP_004086.1	Q13541	4EBP1_HUMAN	eukaryotic translation initiation factor 4E binding protein 1	67					G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|positive regulation of mitotic cell cycle|TOR signaling cascade|translation	cytosol		p.V67V(1)		endometrium(1)|lung(1)|ovary(1)|urinary_tract(1)	4	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)				ACTCACCTGTGACCAAAACAC	0.572000													21	81					2.70639e-06	4.74802e-06	0.002299	1	0
MYH2	4620	broad.mit.edu	37	17	10424725	10424725	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10424725C>T	ENST00000245503.5	-	40	6082	c.5698G>A	c.(5698-5700)Gct>Act	p.A1900T	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Missense_Mutation_p.A667T|MYH2_ENST00000397183.2_Missense_Mutation_p.A1900T	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1900					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CGGAATTTAGCTAGATTGGTG	0.473000													44	118					0	0	0.003610	0	0
SLC5A8	160728	broad.mit.edu	37	12	101603614	101603614	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:101603614G>T	ENST00000536262.2	-	1	571	c.13C>A	c.(13-15)Cgg>Agg	p.R5R		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	5					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CCGATGCCCCGTGGCGTGTCC	0.706000													7	13					0.000157383	0.000261914	0.003080	1	0
PPP1R3F	89801	broad.mit.edu	37	X	49142667	49142667	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:49142667G>A	ENST00000055335.6	+	4	1531	c.1515G>A	c.(1513-1515)gcG>gcA	p.A505A	PPP1R3F_ENST00000466508.1_Silent_p.A159A|PPP1R3F_ENST00000495799.1_Silent_p.A159A|PPP1R3F_ENST00000376188.1_Silent_p.A159A|PPP1R3F_ENST00000438316.1_Silent_p.A176A	NM_033215.4	NP_149992.3	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory subunit 3F	505						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(4)	27	Ovarian(276;0.236)					CTGTGGCTGCGGGTGGGGCAG	0.657000													8	2					0	0	0.003080	0	0
UXS1	80146	broad.mit.edu	37	2	106739524	106739524	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:106739524C>T	ENST00000283148.7	-	9	758	c.661G>A	c.(661-663)Gag>Aag	p.E221K	UXS1_ENST00000540130.1_Missense_Mutation_p.E159K|UXS1_ENST00000428048.2_Missense_Mutation_p.E60K|UXS1_ENST00000409501.3_Missense_Mutation_p.E216K|UXS1_ENST00000409032.1_Missense_Mutation_p.E48K	NM_001253875.1|NM_025076.4	NP_001240804.1|NP_079352.2	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	216					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						CAGTAATCCTCACTTTGAGGG	0.453000													25	62					0	0	0.001061	0	0
CCDC47	57003	broad.mit.edu	37	17	61833679	61833679	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:61833679C>A	ENST00000225726.5	-	8	1251	c.869G>T	c.(868-870)gGa>gTa	p.G290V	CCDC47_ENST00000582252.1_Missense_Mutation_p.G290V|CCDC47_ENST00000403162.3_Missense_Mutation_p.G290V	NM_020198.2	NP_064583.2	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47	290						integral to membrane	protein binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	18						ATACTTTGCTCCAGACTTAGG	0.408000													21	49					2.37509e-13	4.91931e-13	0.001523	1	0
NSD1	64324	broad.mit.edu	37	5	176709538	176709538	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:176709538C>T	ENST00000439151.2	+	19	6010	c.5965C>T	c.(5965-5967)Caa>Taa	p.Q1989*	NSD1_ENST00000347982.4_Nonsense_Mutation_p.Q1720*|NSD1_ENST00000354179.4_Nonsense_Mutation_p.Q1720*|NSD1_ENST00000361032.4_Nonsense_Mutation_p.Q1886*	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1989	SET.			RYAQEH -> KHAHEN (in Ref. 3; AAK92049).	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCGCTATGCTCAAGAACATGA	0.368000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			24	95					0	0	0.003954	0	0
HIPK4	147746	broad.mit.edu	37	19	40886623	40886623	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:40886623G>T	ENST00000291823.2	-	3	1559	c.1275C>A	c.(1273-1275)gcC>gcA	p.A425A		NM_144685.3	NP_653286.2	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	425						cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	20			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			GCTGGTCGATGGCTCTTTGCA	0.617000													41	79					9.85521e-28	2.45098e-27	0.001287	1	0
LMLN	89782	broad.mit.edu	37	3	197746225	197746225	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:197746225A>T	ENST00000330198.4	+	12	1356	c.1334A>T	c.(1333-1335)aAg>aTg	p.K445M	LMLN_ENST00000482695.1_Missense_Mutation_p.K430M|LMLN_ENST00000420910.2_Missense_Mutation_p.K482M|LMLN_ENST00000332636.5_Missense_Mutation_p.K393M	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	445					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		AATTTGCAGAAGTTCCCTAAG	0.468000													16	67					0	0	0.004007	0	0
SEC14L1	6397	broad.mit.edu	37	17	75212635	75212635	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:75212635C>T	ENST00000392476.2	+	20	2708	c.2149C>T	c.(2149-2151)Cga>Tga	p.R717*	SEC14L1_ENST00000413679.2_3'UTR|SEC14L1_ENST00000430767.4_3'UTR|SEC14L1_ENST00000436233.4_3'UTR|SEC14L1_ENST00000443798.4_Nonsense_Mutation_p.R717*	NM_001204408.1	NP_001191337.1	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	0					transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						TCTCAGATGGCGATTTTGCTG	0.512000													84	223					0	0	0.003610	0	0
SLA	6503	broad.mit.edu	37	8	134050883	134050883	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:134050883C>A	ENST00000338087.5	-	9	1536	c.717G>T	c.(715-717)ctG>ctT	p.L239L	TG_ENST00000377869.1_Intron|TG_ENST00000542445.1_Intron|SLA_ENST00000395352.3_Silent_p.L256L|TG_ENST00000519543.1_Intron|TG_ENST00000220616.4_Intron|SLA_ENST00000524345.1_Silent_p.L131L|SLA_ENST00000427060.2_Silent_p.L279L|SLA_ENST00000517648.1_Silent_p.L212L	NM_001045556.2	NP_001039021.1	Q13239	SLAP1_HUMAN	Src-like-adaptor	239	SLA C-terminal.					endosome	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(6)|prostate(1)|skin(1)	17	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			CCTCACTGGTCAGGGACAGGT	0.522000													37	75					8.73648e-17	1.95257e-16	0.004289	1	0
SYNE1	23345	broad.mit.edu	37	6	152725381	152725381	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:152725381T>G	ENST00000367255.5	-	46	7393	c.6792A>C	c.(6790-6792)ttA>ttC	p.L2264F	SYNE1_ENST00000448038.1_Missense_Mutation_p.L2271F|SYNE1_ENST00000265368.4_Missense_Mutation_p.L2264F|SYNE1_ENST00000423061.1_Missense_Mutation_p.L2271F|RP3-398G3.5_ENST00000458194.1_RNA|SYNE1_ENST00000341594.5_Missense_Mutation_p.L2301F	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2264					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GATTTTTAGTTAATTCTTTCA	0.328000										HNSCC(10;0.0054)			40	63					0	0	0.002522	0	0
LEF1	51176	broad.mit.edu	37	4	109088901	109088901	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:109088901C>T	ENST00000379951.2	-	1	1211	c.23G>A	c.(22-24)gGt>gAt	p.G8D	LEF1_ENST00000265165.1_Missense_Mutation_p.G8D|LEF1-AS1_ENST00000436413.1_RNA|LEF1_ENST00000438313.2_Missense_Mutation_p.G8D	NM_001130713.2|NM_001130714.2	NP_001124185.1|NP_001124186.1	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1	8	CTNNB1-binding (By similarity).|Poly-Gly.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	25				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		GCCGCCGCCACCTCCTCCGGA	0.642000													33	83					0	0	0.002836	0	0
ZNF625	90589	broad.mit.edu	37	19	12256682	12256682	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:12256682T>A	ENST00000355738.1	-	4	700	c.351A>T	c.(349-351)atA>atT	p.I117I	ZNF625_ENST00000542938.1_Silent_p.I117I|ZNF625_ENST00000455799.1_3'UTR|ZNF625_ENST00000439556.2_Silent_p.I183I|ZNF625-ZNF20_ENST00000430024.1_Intron			Q96I27	ZN625_HUMAN	zinc finger protein 625	117					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(4)|skin(2)	14						CACTGTGCATTATCCTGTGTC	0.433000													32	89					0	0	0.003271	0	0
TAL1	6886	broad.mit.edu	37	1	47689705	47689705	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:47689705G>A	ENST00000371883.3	-	3	1094	c.518C>T	c.(517-519)cCt>cTt	p.P173L	TAL1_ENST00000294339.3_Missense_Mutation_p.P171L|TAL1_ENST00000459729.1_5'UTR|TAL1_ENST00000371884.2_Missense_Mutation_p.P171L			P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	171					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	15						ATAGGGGGAAGGTCTCCTCTT	0.572000			T	"""TRD@, SIL"""	lymphoblastic leukemia/biphasic								61	52					0	0	0.003610	0	0
CD163	9332	broad.mit.edu	37	12	7653975	7653975	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:7653975C>G	ENST00000359156.4	-	3	419	c.217G>C	c.(217-219)Gga>Cga	p.G73R	CD163_ENST00000432237.2_Missense_Mutation_p.G73R|CD163_ENST00000541972.1_Missense_Mutation_p.G61R|CD163_ENST00000396620.3_Missense_Mutation_p.G73R	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	73	SRCR 1.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						CACACCGTTCCCCACTCCTCC	0.502000													36	95					0	0	0.003755	0	0
BPIFB2	80341	broad.mit.edu	37	20	31601640	31601640	+	Silent	SNP	G	G	C	rs148455522	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:31601640G>C	ENST00000170150.3	+	5	528	c.333G>C	c.(331-333)acG>acC	p.T111T		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	111						extracellular region	lipid binding										TGGAGCTGACGCTGCCTGTGG	0.617000													10	54					0	0	0.000443	0	0
PINK1	65018	broad.mit.edu	37	1	20977105	20977105	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:20977105T>A	ENST00000321556.4	+	8	1761	c.1667T>A	c.(1666-1668)aTg>aAg	p.M556K	PINK1_ENST00000492302.1_3'UTR|PINK1-AS_ENST00000451424.1_RNA	NM_032409.2	NP_115785.1	Q9BXM7	PINK1_HUMAN	PTEN induced putative kinase 1	556					cell death|intracellular protein kinase cascade|mitochondrion degradation|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of release of cytochrome c from mitochondria|regulation of protein complex assembly|regulation of protein ubiquitination|response to stress	cytosol|integral to membrane|mitochondrial outer membrane	ATP binding|C3HC4-type RING finger domain binding|calcium-dependent protein kinase activity|magnesium ion binding|protein serine/threonine kinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)	14		all_lung(284;2.72e-05)|Lung NSC(340;2.94e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.21e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000146)|Kidney(64;0.000182)|GBM - Glioblastoma multiforme(114;0.000497)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AAAATGAAGATGCTCTTTCTG	0.542000													32	23					0	0	0.002445	0	0
FNDC3B	64778	broad.mit.edu	37	3	172059019	172059019	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:172059019C>T	ENST00000336824.4	+	17	2068	c.1969C>T	c.(1969-1971)Cag>Tag	p.Q657*	FNDC3B_ENST00000416957.1_Nonsense_Mutation_p.Q657*|FNDC3B_ENST00000415807.2_Nonsense_Mutation_p.Q657*	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	657	Fibronectin type-III 4.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		CGGACACAGCCAGGTTGGTTT	0.443000													160	139					0	0	0.003610	0	0
INPP4B	8821	broad.mit.edu	37	4	142950038	142950038	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:142950038T>C	ENST00000513000.1	-	27	3105	c.2672A>G	c.(2671-2673)aAg>aGg	p.K891R	INPP4B_ENST00000308502.4_Missense_Mutation_p.K891R|INPP4B_ENST00000262992.4_Missense_Mutation_p.K891R|INPP4B_ENST00000508116.1_Missense_Mutation_p.K891R	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	891					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					TTTGATATTCTTCAGTACATT	0.393000													11	31					0	0	0.000673	0	0
ZPBP	11055	broad.mit.edu	37	7	50070687	50070687	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:50070687C>A	ENST00000046087.2	-	5	776		c.e5+1		ZPBP_ENST00000419417.1_Splice_Site|ZPBP_ENST00000491129.1_Intron	NM_001159878.1|NM_007009.2	NP_001153350.1|NP_008940.2	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein						binding of sperm to zona pellucida	extracellular region				NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(3)	29	Glioma(55;0.08)|all_neural(89;0.245)					TATAGACTTACCTGAAAATGC	0.299000													4	52					0.000602214	0.000991505	0.000602	1	0
NCKAP5L	57701	broad.mit.edu	37	12	50186272	50186272	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:50186272A>G	ENST00000335999.6	-	12	3950	c.3749T>C	c.(3748-3750)aTg>aCg	p.M1250T		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	1246	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						GGGTGGGCACATGAGAGGGTC	0.632000													8	27					0	0	0.003080	0	0
PRKDC	5591	broad.mit.edu	37	8	48746771	48746771	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:48746771T>C	ENST00000314191.2	-	60	8191	c.8135A>G	c.(8134-8136)gAt>gGt	p.D2712G	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.D2712G	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2713	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CACTTTGTTATCCACCTCGTC	0.488000								Non-homologous end-joining					115	238					0	0	0.003610	0	0
KAT6B	23522	broad.mit.edu	37	10	76788996	76788996	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:76788996G>T	ENST00000287239.4	+	18	4903	c.4414G>T	c.(4414-4416)Gag>Tag	p.E1472*	KAT6B_ENST00000372725.1_Nonsense_Mutation_p.E1180*|KAT6B_ENST00000372724.1_Nonsense_Mutation_p.E1180*|KAT6B_ENST00000372711.1_Nonsense_Mutation_p.E1289*|KAT6B_ENST00000372714.1_Nonsense_Mutation_p.E1180*	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	1472					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										CTCGAACCCAGAGGTCTTAAT	0.512000													21	66					1.10513e-12	2.25636e-12	0.002299	1	0
ZEB1	6935	broad.mit.edu	37	10	31815599	31815599	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:31815599G>T	ENST00000446923.2	+	9	3125		c.e9-1		ZEB1_ENST00000320985.10_Splice_Site|ZEB1_ENST00000542815.3_Splice_Site|ZEB1_ENST00000560721.2_Splice_Site|ZEB1_ENST00000361642.5_Splice_Site	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1						cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				TTATTTTGCAGGTAAAAGACC	0.348000													6	19					0.00198382	0.00323176	0.001984	1	0
CHP2	63928	broad.mit.edu	37	16	23768878	23768878	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:23768878A>G	ENST00000300113.2	+	7	988	c.565A>G	c.(565-567)Aaa>Gaa	p.K189E		NM_022097.2	NP_071380.1	O43745	CHP2_HUMAN	calcineurin-like EF-hand protein 2	189							calcium ion binding			central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(2)|stomach(1)	9				GBM - Glioblastoma multiforme(48;0.0144)		CGTTGAGCAAAAAATGAGCAT	0.527000													57	177					0	0	0.003610	0	0
TJP2	9414	broad.mit.edu	37	9	71835869	71835869	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:71835869G>A	ENST00000377245.4	+	5	617	c.409G>A	c.(409-411)Gac>Aac	p.D137N	TJP2_ENST00000453658.2_Missense_Mutation_p.D114N|TJP2_ENST00000265384.7_Missense_Mutation_p.D137N|TJP2_ENST00000535702.1_Missense_Mutation_p.D141N|TJP2_ENST00000539225.1_Missense_Mutation_p.D168N|TJP2_ENST00000348208.4_Missense_Mutation_p.D137N	NM_004817.3	NP_004808.2	Q9UDY2	ZO2_HUMAN	tight junction protein 2	137					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(5)|lung(9)|prostate(3)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	35						GGATCAGGATGACCGGGCTTT	0.612000													7	22					0	0	0.003080	0	0
MYPN	84665	broad.mit.edu	37	10	69961674	69961674	+	Silent	SNP	C	C	A	rs139820597	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:69961674C>A	ENST00000358913.5	+	18	4070	c.3582C>A	c.(3580-3582)cgC>cgA	p.R1194R	MYPN_ENST00000540630.1_Silent_p.R1194R|MYPN_ENST00000354393.2_Silent_p.R919R	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	1194	Ig-like 5.|Interaction with ACTN.					nucleus|sarcomere	actin binding	p.R1194R(1)		breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						TGGAGTGCCGCGTGATAGGCA	0.547000													34	84					1.56738e-10	3.08102e-10	0.004289	1	0
CSN2	1447	broad.mit.edu	37	4	70823471	70823471	+	Missense_Mutation	SNP	A	A	T	rs139725489		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:70823471A>T	ENST00000353151.3	-	5	207	c.196T>A	c.(196-198)Tat>Aat	p.Y66N		NM_001891.2	NP_001882.1	P05814	CASB_HUMAN	casein beta	66					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|skin(2)	12						ACGAATGGATAGATCAGAGGC	0.443000													21	56					0	0	0.001882	0	0
CD86	942	broad.mit.edu	37	3	121838297	121838297	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:121838297T>C	ENST00000330540.2	+	7	1022	c.906T>C	c.(904-906)caT>caC	p.H302H	CD86_ENST00000264468.5_Silent_p.H89H|CD86_ENST00000493101.1_Silent_p.H190H|CD86_ENST00000469710.1_Silent_p.H220H|CD86_ENST00000393627.2_Silent_p.H296H	NM_175862.4	NP_787058.4	P42081	CD86_HUMAN	CD86 molecule	302					interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	23				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	AAAAAATCCATATACCTGAAA	0.338000													17	57					0	0	0.001216	0	0
SMS	6611	broad.mit.edu	37	X	22010722	22010722	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:22010722G>A	ENST00000404933.2	+	10	1205	c.953G>A	c.(952-954)tGt>tAt	p.C318Y	SMS_ENST00000379404.1_Missense_Mutation_p.C265Y|SMS_ENST00000415881.2_Missense_Mutation_p.C222Y	NM_004595.4	NP_004586.2	P52788	SPSY_HUMAN	spermine synthase	318					methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(2)	14					Spermine(DB00127)	TAGGGGAACTGTGTCAATCTG	0.453000													4	7					0	0	0.000248	0	0
ZNF507	22847	broad.mit.edu	37	19	32844667	32844667	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:32844667G>A	ENST00000311921.3	+	2	1123	c.931G>A	c.(931-933)Gag>Aag	p.E311K	ZNF507_ENST00000355898.5_Missense_Mutation_p.E311K|ZNF507_ENST00000544431.1_Missense_Mutation_p.E311K|ZNF507_ENST00000587084.1_3'UTR	NM_001136156.1|NM_014910.4	NP_001129628.1|NP_055725.2	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	31	Esophageal squamous(110;0.162)					TGCTATTGGAGAGAGTGAACT	0.473000													47	159					0	0	0.003610	0	0
OBSCN	84033	broad.mit.edu	37	1	228481186	228481186	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:228481186G>T	ENST00000570156.2	+	46	12361	c.12287G>T	c.(12286-12288)gGa>gTa	p.G4096V	OBSCN_ENST00000366709.4_Missense_Mutation_p.G786V|OBSCN_ENST00000359599.6_Missense_Mutation_p.G2514V|OBSCN_ENST00000366707.4_Missense_Mutation_p.G786V|OBSCN_ENST00000422127.1_Missense_Mutation_p.G3667V|OBSCN_ENST00000284548.11_Missense_Mutation_p.G3667V	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3138	Ig-like 42.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CTCAGAGATGGAGACAGACAC	0.642000													25	50					4.87955e-14	1.02762e-13	0.005443	1	0
IGHV3-48	28424	broad.mit.edu	37	14	106994246	106994246	+	RNA	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:106994246C>A	ENST00000390624.2	-	0	100																											ACAAGGAAAACCCAGCACAGC	0.463000													54	156					1.39843e-22	3.40612e-22	0.003610	1	0
VNN2	8875	broad.mit.edu	37	6	133072643	133072643	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:133072643C>G	ENST00000326499.6	-	5	965	c.841G>C	c.(841-843)Gca>Cca	p.A281P	VNN2_ENST00000525270.1_Missense_Mutation_p.A228P|VNN2_ENST00000525289.1_Intron	NM_004665.2	NP_004656.2	O95498	VNN2_HUMAN	vanin 2	281	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		CCATTTGGTGCATAAATACCA	0.413000													23	45					0	0	0.002299	0	0
NDNF	79625	broad.mit.edu	37	4	121958113	121958113	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:121958113G>C	ENST00000379692.4	-	4	1539	c.1013C>G	c.(1012-1014)gCc>gGc	p.A338G		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	338										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						CTTCTGTTTGGCTTCTTCCTT	0.438000													22	71					0	0	0.001882	0	0
NLRC4	58484	broad.mit.edu	37	2	32474682	32474682	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:32474682G>A	ENST00000404025.2	-	5	2739	c.2251C>T	c.(2251-2253)Ctg>Ttg	p.L751L	NLRC4_ENST00000360906.5_Silent_p.L751L|NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000402280.1_Silent_p.L751L			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	751					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					ATACCCGGCAGCCGTTGATTC	0.393000													69	184					0	0	0.003610	0	0
INPP4B	8821	broad.mit.edu	37	4	143235901	143235901	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:143235901G>T	ENST00000513000.1	-	9	820	c.387C>A	c.(385-387)gtC>gtA	p.V129V	INPP4B_ENST00000509777.1_Silent_p.V129V|INPP4B_ENST00000308502.4_Silent_p.V129V|INPP4B_ENST00000262992.4_Silent_p.V129V|INPP4B_ENST00000508116.1_Silent_p.V129V	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	129	C2.				signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					GTTCTGGTAGGACACTGGTTC	0.433000													36	99					9.17885e-22	2.21418e-21	0.003271	1	0
TM2D2	83877	broad.mit.edu	37	8	38853858	38853858	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:38853858T>C	ENST00000456397.2	-	1	194	c.101A>G	c.(100-102)cAc>cGc	p.H34R	TM2D2_ENST00000412303.1_Intron|TM2D2_ENST00000522434.1_Intron|TM2D2_ENST00000397070.2_5'UTR|TM2D2_ENST00000456845.2_Intron	NM_078473.2	NP_510882.1	Q9BX73	TM2D2_HUMAN	TM2 domain containing 2	34						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(2)	6		all_lung(54;0.00338)|Lung NSC(58;0.0133)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			ATTTTGCGAGTGGCTCCGAGA	0.627000													40	82					0	0	0.003214	0	0
MTFR1	9650	broad.mit.edu	37	8	66605983	66605983	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:66605983A>T	ENST00000262146.4	+	4	396	c.270A>T	c.(268-270)tcA>tcT	p.S90S	MTFR1_ENST00000517944.1_3'UTR|MTFR1_ENST00000458689.2_Silent_p.S57S	NM_014637.3	NP_055452.3	Q15390	MTFR1_HUMAN	mitochondrial fission regulator 1	90						mitochondrion|plasma membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(1)|pancreas(1)|urinary_tract(1)	11			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)			GAGAGTGTTCAGCAAGACTAA	0.408000													16	25					0	0	0.004007	0	0
MUC16	94025	broad.mit.edu	37	19	9059286	9059286	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9059286G>A	ENST00000397910.4	-	3	28363	c.28160C>T	c.(28159-28161)tCa>tTa	p.S9387L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9389	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGCTGTGCTTGATGAGTCCAA	0.527000													35	103					0	0	0.002836	0	0
OR4M1	441670	broad.mit.edu	37	14	20248683	20248683	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20248683C>A	ENST00000315957.4	+	1	283	c.202C>A	c.(202-204)Ctc>Atc	p.L68I		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TAATCTGGCCCTCCTTGATAT	0.423000													66	532					3.07281e-33	7.79663e-33	0.003610	1	0
SDK1	221935	broad.mit.edu	37	7	4091359	4091359	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:4091359G>C	ENST00000404826.2	+	19	2947	c.2808G>C	c.(2806-2808)acG>acC	p.T936T	SDK1_ENST00000389531.3_Silent_p.T936T	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	936	Fibronectin type-III 3.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GACACATAACGAACCTGAAGA	0.577000													40	83					0	0	0.005524	0	0
COL8A1	1295	broad.mit.edu	37	3	99513943	99513943	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:99513943C>A	ENST00000261037.3	+	5	1578	c.1198C>A	c.(1198-1200)Cct>Act	p.P400T	COL8A1_ENST00000273342.4_Missense_Mutation_p.P400T	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	400	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						AATCCCAGGTCCTATGGGCCC	0.612000													8	62					0.00307968	0.0049967	0.003080	1	0
RYR3	6263	broad.mit.edu	37	15	34040373	34040373	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:34040373G>A	ENST00000389232.4	+	54	8118	c.8048G>A	c.(8047-8049)gGc>gAc	p.G2683D	RYR3_ENST00000415757.3_Missense_Mutation_p.G2683D	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2683	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGGCTGTGGGCTGGACTGTG	0.522000													22	28					0	0	0.003330	0	0
HERC5	51191	broad.mit.edu	37	4	89407376	89407376	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:89407376T>C	ENST00000264350.3	+	14	2001	c.1848T>C	c.(1846-1848)acT>acC	p.T616T	HERC5_ENST00000508159.1_Silent_p.T254T	NM_016323.3	NP_057407.2	Q9UII4	HERC5_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 5	616					innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity	p.T616T(1)		NS(2)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|liver(2)|lung(17)|ovary(4)|prostate(1)|skin(4)	53		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		GGAAAATGACTGTGGTAGGTA	0.373000													13	32					0	0	0.001368	0	0
SPRR1B	6699	broad.mit.edu	37	1	153004977	153004977	+	Splice_Site	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:153004977A>G	ENST00000392661.3	+	1	156	c.156_splice	c.e1+1	p.K52_splice	SPRR1B_ENST00000307098.4_Silent_p.K52K			P22528	SPR1B_HUMAN	small proline-rich protein 1B	68	6 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity	p.C41_P64delCHPKVPEPCHPKVPEPCQPKVPEP(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|ovary(2)|skin(2)	9	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCACCCCAAAGTGCCCGAGC	0.627000													13	122					0	0	0.001882	0	0
OR2T8	343172	broad.mit.edu	37	1	248084536	248084536	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248084536T>C	ENST00000319968.4	+	1	217	c.217T>C	c.(217-219)Tcc>Ccc	p.S73P		NM_001005522.1	NP_001005522.1	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T, member 8	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(20)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GATGCTGGTTTCCACCACTGT	0.572000													6	129					0	0	0.004482	0	0
ARHGAP28	79822	broad.mit.edu	37	18	6876197	6876197	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:6876197C>A	ENST00000419673.2	+	9	1020	c.803C>A	c.(802-804)gCt>gAt	p.A268D	ARHGAP28_ENST00000314319.3_Missense_Mutation_p.A268D|ARHGAP28_ENST00000531294.1_Missense_Mutation_p.A263D|ARHGAP28_ENST00000418986.1_Missense_Mutation_p.A268D|ARHGAP28_ENST00000400091.2_Missense_Mutation_p.A427D|ARHGAP28_ENST00000383472.4_Missense_Mutation_p.A427D|ARHGAP28_ENST00000532996.1_Missense_Mutation_p.A250D|ARHGAP28_ENST00000262227.3_Missense_Mutation_p.A375D	NM_001010000.2	NP_001010000.1	B4DXL2	B4DXL2_HUMAN	Rho GTPase activating protein 28	250					signal transduction	intracellular				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	37		Colorectal(10;0.168)				GGATGTACTGCTAAAGTCAAG	0.388000													65	63					5.26073e-25	1.30028e-24	0.003610	1	0
KIAA1377	57562	broad.mit.edu	37	11	101834193	101834193	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:101834193T>C	ENST00000263468.8	+	6	2697	c.2427T>C	c.(2425-2427)aaT>aaC	p.N809N	KIAA1377_ENST00000537689.1_Silent_p.N610N	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	809							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		CTACATCAAATATTAGAAGTG	0.348000													9	28					0	0	0.004482	0	0
ADPRH	141	broad.mit.edu	37	3	119301305	119301305	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:119301305C>A	ENST00000478399.1	+	2	1694	c.289C>A	c.(289-291)Cgg>Agg	p.R97R	ADPRH_ENST00000478927.1_Silent_p.R97R|ADPRH_ENST00000471850.1_Intron|ADPRH_ENST00000357003.3_Silent_p.R97R|ADPRH_ENST00000465513.1_Silent_p.R97R			P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	97					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			breast(1)|kidney(1)|lung(10)|ovary(1)	13		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		CATGGATGGGCGGGCACCAGG	0.473000													14	84					9.7654e-05	0.000163463	0.000958	1	0
ALDH5A1	7915	broad.mit.edu	37	6	24533787	24533787	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:24533787G>A	ENST00000357578.3	+	10	1600	c.1455G>A	c.(1453-1455)ctG>ctA	p.L485L	ALDH5A1_ENST00000491546.1_Silent_p.L457L|ALDH5A1_ENST00000546278.1_Silent_p.L397L|ALDH5A1_ENST00000348925.2_Silent_p.L498L	NM_001080.3	NP_001071.1	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5 family, member A1	485					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	CAGAGCAGCTGGAAGTGGGCA	0.493000													78	71					0	0	0.003610	0	0
CELSR2	1952	broad.mit.edu	37	1	109803804	109803804	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:109803804G>A	ENST00000271332.3	+	3	4160	c.4099G>A	c.(4099-4101)Gtg>Atg	p.V1367M		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1367	Laminin G-like 1.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTACTGCCAGGTGACCACGCG	0.632000													28	67					0	0	0.001512	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433332	140433332	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140433332A>T	ENST00000306549.3	+	1	2354	c.2277A>T	c.(2275-2277)tcA>tcT	p.S759S		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		759					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATGTGTTCAGCCACTGGCA	0.443000													6	92					0	0	0.001168	0	0
ZNF519	162655	broad.mit.edu	37	18	14105881	14105881	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:14105881G>A	ENST00000590202.1	-	3	810	c.658C>T	c.(658-660)Cca>Tca	p.P220S	ZNF519_ENST00000589203.1_Intron|ZNF519_ENST00000589498.1_Intron	NM_145287.3	NP_660330.2	Q8TB69	ZN519_HUMAN	zinc finger protein 519	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	18						TTTGAGAATGGGTCAGAAGTT	0.299000													15	167					0	0	0.003163	0	0
KCNA4	3739	broad.mit.edu	37	11	30033418	30033418	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:30033418G>A	ENST00000328224.6	-	2	2041	c.808C>T	c.(808-810)Cgg>Tgg	p.R270W		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	270						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						TCGTCCTCCCGAAACTTCAAC	0.512000													22	59					0	0	0.001882	0	0
ZNF324B	388569	broad.mit.edu	37	19	58967712	58967712	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:58967712G>T	ENST00000391696.1	+	3	2303	c.1371G>T	c.(1369-1371)gtG>gtT	p.V457V	ZNF324B_ENST00000545523.1_Silent_p.V467V|ZNF324B_ENST00000336614.4_Silent_p.V467V			Q6AW86	Z324B_HUMAN	zinc finger protein 324B	467				D -> G (in Ref. 1; BAC87113).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGGGCGCCGTGCTGCTCAGCC	0.682000													23	68					1.22574e-08	2.29912e-08	0.002299	1	0
PCDHA5	56143	broad.mit.edu	37	5	140203532	140203532	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140203532G>T	ENST00000529859.1	+	1	2172	c.2172G>T	c.(2170-2172)gcG>gcT	p.A724A	PCDHA5_ENST00000529619.1_Silent_p.A724A|PCDHA5_ENST00000378126.3_Silent_p.A724A|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCTCGGCGCAGCCCACCG	0.657000													20	63					2.39187e-15	5.20335e-15	0.001216	1	0
PTGS1	5742	broad.mit.edu	37	9	125154751	125154751	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:125154751C>A	ENST00000362012.2	+	11	1733	c.1728C>A	c.(1726-1728)taC>taA	p.Y576*	PTGS1_ENST00000540753.1_Nonsense_Mutation_p.Y514*|PTGS1_ENST00000223423.4_Nonsense_Mutation_p.Y539*|PTGS1_ENST00000373698.5_Nonsense_Mutation_p.Y467*	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	576					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	CCTGTCCCTACGTTTCCTTCC	0.582000													31	100					2.61193e-14	5.55312e-14	0.001786	1	0
TRAT1	50852	broad.mit.edu	37	3	108568018	108568018	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:108568018A>G	ENST00000295756.6	+	5	450	c.220A>G	c.(220-222)Atg>Gtg	p.M74V	TRAT1_ENST00000426646.1_Missense_Mutation_p.M37V	NM_016388.2	NP_057472.2	Q6PIZ9	TRAT1_HUMAN	T cell receptor associated transmembrane adaptor 1	74					cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(3)	28						CCAAGAACCAATGGATGAAAA	0.338000													15	71					0	0	0.003163	0	0
KIT	3815	broad.mit.edu	37	4	55604710	55604710	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:55604710A>G	ENST00000288135.5	+	21	3015	c.2918A>G	c.(2917-2919)cAc>cGc	p.H973R		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	973					male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTGCTTGTGCACGACGATGTC	0.512000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				46	111					0	0	0.003610	0	0
TRPC6	7225	broad.mit.edu	37	11	101344380	101344380	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:101344380C>G	ENST00000344327.3	-	7	2293	c.1869G>C	c.(1867-1869)ctG>ctC	p.L623L	TRPC6_ENST00000532133.1_Silent_p.L545L|TRPC6_ENST00000348423.4_Silent_p.L507L|TRPC6_ENST00000360497.4_Silent_p.L568L	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	623					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GTGATATCTGCAGAGGTCCAA	0.348000													17	60					0	0	0.000958	0	0
SLC30A9	10463	broad.mit.edu	37	4	42022531	42022531	+	Splice_Site	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:42022531A>T	ENST00000264451.6	+	4	613	c.434_splice	c.e4+1	p.S145_splice		NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9	145					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						CCTCAAATCCAGGTAATTTTT	0.348000													30	67					0	0	0.001271	0	0
UBE3B	89910	broad.mit.edu	37	12	109959106	109959106	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:109959106G>C	ENST00000342494.3	+	20	2825	c.2230G>C	c.(2230-2232)Gac>Cac	p.D744H	UBE3B_ENST00000434735.2_Missense_Mutation_p.D744H	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	744	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						GAGAGTTTTTGACCCAGCACT	0.488000													31	99					0	0	0.001786	0	0
CPNE5	57699	broad.mit.edu	37	6	36766231	36766231	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:36766231C>A	ENST00000244751.2	-	5	952		c.e5+1			NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V											central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						GCAGAACTCACGTGTTTGGAT	0.512000													28	28					8.58068e-18	1.95033e-17	0.001271	1	0
ZNF467	168544	broad.mit.edu	37	7	149462862	149462862	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:149462862G>A	ENST00000302017.3	-	5	1142	c.729C>T	c.(727-729)ccC>ccT	p.P243P	ZNF467_ENST00000484747.1_Intron	NM_207336.1	NP_997219.1	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|urinary_tract(1)	13	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGCACGGGTAGGGCCGCTCGC	0.687000													12	20					0	0	0.001368	0	0
LARP4	113251	broad.mit.edu	37	12	50847384	50847384	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:50847384C>G	ENST00000398473.2	+	9	1058	c.946C>G	c.(946-948)Cag>Gag	p.Q316E	LARP4_ENST00000293618.8_Missense_Mutation_p.Q316E|LARP4_ENST00000347328.5_Intron|LARP4_ENST00000518444.1_Missense_Mutation_p.Q315E|LARP4_ENST00000429001.3_Missense_Mutation_p.Q322E|LARP4_ENST00000518561.1_Missense_Mutation_p.Q246E|LARP4_ENST00000522085.1_Missense_Mutation_p.Q316E	NM_052879.4|NM_199188.2	NP_443111.4|NP_954658.2	Q71RC2	LARP4_HUMAN	La ribonucleoprotein domain family, member 4	316							nucleotide binding|RNA binding			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						TCCTCACCAACAGTACTCGGT	0.393000													27	81					0	0	0.001271	0	0
PHACTR3	116154	broad.mit.edu	37	20	58330273	58330273	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:58330273C>T	ENST00000371015.1	+	4	862	c.395C>T	c.(394-396)cCc>cTc	p.P132L	PHACTR3_ENST00000355648.4_Missense_Mutation_p.P91L|PHACTR3_ENST00000359926.3_Missense_Mutation_p.P129L|PHACTR3_ENST00000395639.4_Missense_Mutation_p.P91L|PHACTR3_ENST00000395636.2_Missense_Mutation_p.P91L|PHACTR3_ENST00000541461.1_Missense_Mutation_p.P91L|PHACTR3_ENST00000361300.4_Missense_Mutation_p.P91L	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	132						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GATGGAGGACCCCGATCTGTA	0.587000													9	17					0	0	0.000443	0	0
GP2	2813	broad.mit.edu	37	16	20327337	20327337	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:20327337C>A	ENST00000302555.5	-	9	1591	c.1442G>T	c.(1441-1443)aGt>aTt	p.S481I	GP2_ENST00000381362.4_Missense_Mutation_p.S484I|GP2_ENST00000341642.5_Missense_Mutation_p.S334I|GP2_ENST00000381360.5_Missense_Mutation_p.S337I			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	484	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CGGTACTTCACTGCGGACTTG	0.483000													24	85					2.79863e-10	5.46387e-10	0.004656	1	0
C10orf88	80007	broad.mit.edu	37	10	124708266	124708266	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:124708266T>A	ENST00000481909.1	-	4	771	c.547A>T	c.(547-549)Agg>Tgg	p.R183W	C10orf88_ENST00000368891.5_5'UTR	NM_024942.3	NP_079218.2	Q9H8K7	CJ088_HUMAN	chromosome 10 open reading frame 88	183										breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)	18		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		AGGTCTATCCTTGATCCTAGA	0.458000													28	33					0	0	0.001061	0	0
SCN10A	6336	broad.mit.edu	37	3	38763808	38763808	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:38763808C>A	ENST00000449082.2	-	19	3447	c.3448G>T	c.(3448-3450)Gag>Tag	p.E1150*		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1150					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CAGCTGTGCTCCACGATACGG	0.547000													20	33					0.000132079	0.000220534	0.001216	1	0
ZBTB38	253461	broad.mit.edu	37	3	141163889	141163889	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:141163889A>T	ENST00000514251.1	+	4	2938	c.2659A>T	c.(2659-2661)Agc>Tgc	p.S887C	ZBTB38_ENST00000321464.5_Missense_Mutation_p.S888C|ZBTB38_ENST00000441582.2_Missense_Mutation_p.S887C			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	887					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						CAGTGGAGACAGCCCACTCGG	0.507000													19	65					0	0	0.001216	0	0
TKTL2	84076	broad.mit.edu	37	4	164394427	164394427	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:164394427T>C	ENST00000280605.3	-	1	620	c.460A>G	c.(460-462)Atg>Gtg	p.M154V		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	154						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CCATCTCCCATAAGGCAGAAC	0.542000													30	80					0	0	0.001512	0	0
ZNF451	26036	broad.mit.edu	37	6	57006110	57006110	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:57006110A>T	ENST00000370706.4	+	8	957	c.713A>T	c.(712-714)gAt>gTt	p.D238V	RP11-203B9.4_ENST00000592038.1_RNA|ZNF451_ENST00000357489.3_Missense_Mutation_p.D238V|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000586668.1_RNA|ZNF451_ENST00000491832.2_Missense_Mutation_p.D238V|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|RP11-203B9.4_ENST00000592500.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			GAAGCCACAGATGATGGACAT	0.323000													6	42					0	0	0.001168	0	0
IKZF4	64375	broad.mit.edu	37	12	56429106	56429106	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:56429106G>A	ENST00000262032.5	+	12	2116	c.1749G>A	c.(1747-1749)aaG>aaA	p.K583K	IKZF4_ENST00000547167.1_Silent_p.K583K|RP11-603J24.4_ENST00000551846.1_RNA|IKZF4_ENST00000547791.1_Silent_p.K538K|IKZF4_ENST00000431367.2_Silent_p.K481K			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	583					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGGAGCATAAGGTGGGCTAGC	0.547000													7	191					0	0	0.001984	0	0
KLB	152831	broad.mit.edu	37	4	39408952	39408952	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:39408952G>T	ENST00000257408.4	+	1	480	c.383G>T	c.(382-384)aGt>aTt	p.S128I		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	128	Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						AATGGTTCCAGTGACAGTTAT	0.398000													37	113					2.09667e-21	5.02749e-21	0.003755	1	0
OR6Q1	219952	broad.mit.edu	37	11	57799168	57799168	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:57799168C>A	ENST00000302622.3	+	1	767	c.744C>A	c.(742-744)caC>caA	p.H248Q	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	248					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				GTGCAGCTCACCTGACTGTGG	0.512000													52	139					2.14674e-31	5.4195e-31	0.003610	1	0
TICAM2	353376	broad.mit.edu	37	5	114916308	114916308	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:114916308T>C	ENST00000408996.4	-	4	1539	c.1153A>G	c.(1153-1155)Aag>Gag	p.K385E	TMED7-TICAM2_ENST00000333314.3_3'UTR|TICAM2_ENST00000427199.2_Missense_Mutation_p.K216E|TMED7-TICAM2_ENST00000282382.4_Missense_Mutation_p.K385E	NM_001164468.2|NM_001164469.2	NP_001157940.1|NP_001157941.1			toll-like receptor adaptor molecule 2											cervix(1)|kidney(1)|lung(2)|soft_tissue(1)	5		all_cancers(142;0.0223)|all_epithelial(76;0.000869)|Prostate(80;0.0115)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;4.38e-07)|Epithelial(69;1.62e-06)|all cancers(49;6.93e-05)		TGTTGTGTCTTATACACAGAC	0.378000													17	44					0	0	0.006122	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75929588	75929588	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:75929588G>C	ENST00000262207.4	+	10	1498	c.1030G>C	c.(1030-1032)Ggt>Cgt	p.G344R	CRISPLD1_ENST00000517786.1_Missense_Mutation_p.G158R|CRISPLD1_ENST00000523524.1_Missense_Mutation_p.G156R	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	344	LCCL 1.					extracellular region		p.G344S(1)		biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			AATTCATTATGGTATAATAGA	0.343000													44	62					0	0	0.001706	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973704	29973704	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:29973704C>G	ENST00000378993.1	+	11	2531	c.1858C>G	c.(1858-1860)Cgt>Ggt	p.R620G	IL1RAPL1_ENST00000302196.4_Missense_Mutation_p.R620G	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	620	Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity	p.R620S(2)		biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						TTCACAAATGCGTCAGAAACA	0.532000													7	10					0	0	0.001984	0	0
GPR27	2850	broad.mit.edu	37	3	71804129	71804129	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:71804129T>A	ENST00000304411.2	+	1	929	c.929T>A	c.(928-930)gTg>gAg	p.V310E		NM_018971.1	NP_061844.1	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	310						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(1)	5		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		CGGGTCCTGGTGCGGCCCGGC	0.667000													10	15					0	0	0.000443	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255364	140255364	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140255364A>G	ENST00000398631.2	+	1	307	c.307A>G	c.(307-309)Agt>Ggt	p.S103G	PCDHA9_ENST00000532602.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGGAGTGCAGTATCCACCT	0.557000													74	186					0	0	0.003610	0	0
NRXN1	9378	broad.mit.edu	37	2	50779852	50779852	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:50779852C>T	ENST00000404971.1	-	10	3091	c.1752G>A	c.(1750-1752)gaG>gaA	p.E584E	NRXN1_ENST00000405472.3_Silent_p.E536E|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000402717.3_Silent_p.E536E|NRXN1_ENST00000401669.2_Silent_p.E544E|NRXN1_ENST00000406316.2_Silent_p.E544E|NRXN1_ENST00000406859.3_Silent_p.E544E	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	544	Laminin G-like 3.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CATCTAGCATCTCAATAGCAA	0.448000													30	73					0	0	0.001512	0	0
ASXL3	80816	broad.mit.edu	37	18	31323688	31323688	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:31323688C>A	ENST00000269197.5	+	12	3876	c.3876C>A	c.(3874-3876)tgC>tgA	p.C1292*		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1292	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ACACTCCATGCATAGCCATTA	0.393000													68	53					1.72039e-30	4.32684e-30	0.003610	1	0
CHIT1	1118	broad.mit.edu	37	1	203192687	203192687	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:203192687C>A	ENST00000367229.1	-	5	450	c.416G>T	c.(415-417)tGg>tTg	p.W139L	CHIT1_ENST00000535569.1_Missense_Mutation_p.W130L|CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000255427.3_Missense_Mutation_p.W120L	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	139					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						TGGGTACTCCCAGTCAAGGTC	0.582000													42	83					9.85913e-13	2.01705e-12	0.002222	1	0
TECRL	253017	broad.mit.edu	37	4	65275045	65275045	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:65275045C>A	ENST00000381210.3	-	1	135	c.25G>T	c.(25-27)Gct>Tct	p.A9S	TECRL_ENST00000507440.1_Missense_Mutation_p.A9S	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	9					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						CGTTCCGAAGCGAGGGACTTG	0.393000													25	57					4.59853e-10	8.94307e-10	0.005443	1	0
CAMK2A	815	broad.mit.edu	37	5	149636159	149636159	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:149636159C>A	ENST00000348628.6	-	6	1053	c.388G>T	c.(388-390)Ggg>Tgg	p.G130W	CAMK2A_ENST00000398376.3_Missense_Mutation_p.G130W	NM_015981.3|NM_171825.2	NP_057065.2|NP_741960.1	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II alpha	130	Protein kinase.				interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)	15		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCACCACCCCCATCTGGTGG	0.637000													6	30					3.59834e-05	6.09954e-05	0.001168	1	0
DSCAML1	57453	broad.mit.edu	37	11	117303127	117303127	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:117303127G>C	ENST00000321322.6	-	30	5301	c.5300C>G	c.(5299-5301)cCa>cGa	p.P1767R	DSCAML1_ENST00000527706.1_Missense_Mutation_p.P1497R	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1707					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GATGAGGGTTGGGTGGTGCAA	0.577000													14	35					0	0	0.003163	0	0
TRIO	7204	broad.mit.edu	37	5	14488346	14488346	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:14488346G>T	ENST00000344204.4	+	48	7633	c.7609G>T	c.(7609-7611)Gtg>Ttg	p.V2537L	TRIO_ENST00000537187.1_Intron	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2537					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					CGAGCAGTCCGTGCAGTCCAC	0.721000													7	14					8.12818e-05	0.000136171	0.001984	1	0
NSD1	64324	broad.mit.edu	37	5	176637567	176637567	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:176637567A>T	ENST00000439151.2	+	5	2212	c.2167A>T	c.(2167-2169)Acc>Tcc	p.T723S	NSD1_ENST00000354179.4_Missense_Mutation_p.T454S|NSD1_ENST00000361032.4_Missense_Mutation_p.T620S|NSD1_ENST00000347982.4_Missense_Mutation_p.T454S	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	723					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AGAGCCTGGAACCGAGACGTC	0.428000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			26	58					0	0	0.003954	0	0
TRIML1	339976	broad.mit.edu	37	4	189060957	189060957	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:189060957G>T	ENST00000332517.3	+	1	385	c.245G>T	c.(244-246)cGg>cTg	p.R82L		NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	82					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AGGCAGCTCCGGTCCCAGGTG	0.637000													18	48					6.94344e-10	1.34642e-09	0.006122	1	0
RPH3A	22895	broad.mit.edu	37	12	113307719	113307719	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:113307719C>A	ENST00000389385.4	+	10	1168	c.671C>A	c.(670-672)cCc>cAc	p.P224H	RPH3A_ENST00000415485.3_Missense_Mutation_p.P224H|RPH3A_ENST00000447659.2_Missense_Mutation_p.P175H|RPH3A_ENST00000548866.1_Missense_Mutation_p.P175H|RPH3A_ENST00000549913.2_3'UTR|RPH3A_ENST00000551052.1_Missense_Mutation_p.P220H|RPH3A_ENST00000420983.2_Missense_Mutation_p.P224H|RPH3A_ENST00000543106.2_Missense_Mutation_p.P224H	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	224	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GCCTCTGCTCCCGGGCGAGGA	0.562000													29	62					3.99451e-17	8.97758e-17	0.001786	1	0
GUCY1B3	2983	broad.mit.edu	37	4	156696131	156696131	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:156696131A>T	ENST00000264424.8	+	3	171	c.89A>T	c.(88-90)cAg>cTg	p.Q30L	GUCY1B3_ENST00000503520.1_Missense_Mutation_p.Q30L|GUCY1B3_ENST00000507146.1_5'UTR|GUCY1B3_ENST00000505154.1_5'UTR|GUCY1B3_ENST00000502959.1_Missense_Mutation_p.Q30L|GUCY1B3_ENST00000505764.1_Missense_Mutation_p.Q10L|GUCY1B3_ENST00000513437.1_5'UTR	NM_000857.2	NP_000848.1	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	30					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AAAGAGGCACAGTTAGATGAA	0.318000													41	92					0	0	0.001951	0	0
TIE1	7075	broad.mit.edu	37	1	43770798	43770798	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:43770798G>T	ENST00000372476.3	+	2	414	c.335G>T	c.(334-336)cGg>cTg	p.R112L	TIE1_ENST00000441333.2_Missense_Mutation_p.R112L|TIE1_ENST00000538015.1_Missense_Mutation_p.R112L	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	112					mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCTGGGGCGCGGCGCACGCGC	0.701000													12	16					4.3838e-07	7.88377e-07	0.001855	1	0
SPHKAP	80309	broad.mit.edu	37	2	228881633	228881633	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:228881633A>C	ENST00000392056.3	-	7	3983	c.3937T>G	c.(3937-3939)Tcc>Gcc	p.S1313A	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S1313A	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1313						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCCTCAATGGAGCTAGCCCAC	0.507000													17	27					0	0	0.006122	0	0
GLI3	2737	broad.mit.edu	37	7	42005670	42005670	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:42005670C>A	ENST00000395925.3	-	15	3085	c.3001G>T	c.(3001-3003)Ggc>Tgc	p.G1001C	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1001					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						CTCCTCACGCCGTGGCCCGGC	0.756000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				8	10					0.000274275	0.000453435	0.004482	1	0
FXYD3	5349	broad.mit.edu	37	19	35613703	35613703	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:35613703C>G	ENST00000435734.2	+	7	391	c.132C>G	c.(130-132)tgC>tgG	p.C44W	FXYD3_ENST00000535103.1_Missense_Mutation_p.C101W|FXYD3_ENST00000605550.1_Missense_Mutation_p.C44W|FXYD3_ENST00000346446.5_Missense_Mutation_p.C44W|FXYD3_ENST00000406988.1_Missense_Mutation_p.C44W|FXYD3_ENST00000406242.3_Missense_Mutation_p.C44W|FXYD3_ENST00000603524.1_Missense_Mutation_p.C73W|FXYD3_ENST00000344013.6_Missense_Mutation_p.C44W|FXYD3_ENST00000604804.1_Missense_Mutation_p.C73W|FXYD3_ENST00000605677.1_Missense_Mutation_p.C44W|FXYD3_ENST00000604404.1_Missense_Mutation_p.C44W|FXYD3_ENST00000603181.1_Missense_Mutation_p.C44W|FXYD3_ENST00000604621.1_Missense_Mutation_p.C44W|FXYD3_ENST00000604255.1_Missense_Mutation_p.C101W	NM_001136011.1|NM_021910.2	NP_001129483.1|NP_068710.1	Q14802	FXYD3_HUMAN	FXYD domain containing ion transport regulator 3	44						chloride channel complex|integral to plasma membrane	chloride channel activity			endometrium(1)|lung(2)|prostate(1)	4	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			GGCTCATCTGCGCTGGGGTTC	0.652000													32	75					0	0	0.003271	0	0
PCDH7	5099	broad.mit.edu	37	4	30725162	30725162	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:30725162C>T	ENST00000361762.2	+	1	3126	c.2118C>T	c.(2116-2118)acC>acT	p.T706T	PCDH7_ENST00000543491.1_Silent_p.T706T	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	706	Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						AACATCAGACCACATACACTT	0.443000													29	70					0	0	0.001061	0	0
SURF2	6835	broad.mit.edu	37	9	136226863	136226863	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:136226863T>C	ENST00000371964.4	+	4	416	c.375T>C	c.(373-375)ccT>ccC	p.P125P	SURF2_ENST00000495524.1_3'UTR	NM_017503.3	NP_059973.3	Q15527	SURF2_HUMAN	surfeit 2	125							protein binding			breast(1)|large_intestine(1)|lung(4)	6				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		AGTACGTGCCTGCCTGCCTGG	0.647000													9	23					0	0	0.004482	0	0
ABCB1	5243	broad.mit.edu	37	7	87160614	87160614	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:87160614C>G	ENST00000265724.3	-	22	3098	c.2681G>C	c.(2680-2682)gGg>gCg	p.G894A	ABCB1_ENST00000488737.2_5'UTR|ABCB1_ENST00000543898.1_Missense_Mutation_p.G830A	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	894	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ACTCACCTTCCCAGAACCTTC	0.343000													23	36					0	0	0.002299	0	0
TRMT61B	55006	broad.mit.edu	37	2	29092590	29092590	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:29092590C>A	ENST00000306108.5	-	1	577	c.554G>T	c.(553-555)gGg>gTg	p.G185V		NM_017910.3	NP_060380.3	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B (S. cerevisiae)	185							tRNA (adenine-N1-)-methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)	13						CGGGACTGCCCCCCAGTTACT	0.498000													33	91					2.68265e-12	5.41113e-12	0.002836	1	0
ALDH1L1	10840	broad.mit.edu	37	3	125879696	125879696	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:125879696C>A	ENST00000393434.2	-	2	476	c.127_splice	c.e2+1	p.G43_splice	ALDH1L1_ENST00000455064.2_5'UTR|ALDH1L1_ENST00000393431.2_Splice_Site_p.G43_splice|ALDH1L1_ENST00000273450.3_Splice_Site_p.G53_splice|ALDH1L1_ENST00000452905.2_Splice_Site_p.G43_splice|ALDH1L1_ENST00000472186.1_Splice_Site_p.G43_splice	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	43	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GCTCACTCACCCAGGGGGTCG	0.602000													28	162					9.39395e-14	1.96802e-13	0.001061	1	0
SLC6A15	55117	broad.mit.edu	37	12	85266419	85266419	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:85266419G>A	ENST00000266682.5	-	8	1805	c.1264C>T	c.(1264-1266)Cat>Tat	p.H422Y	SLC6A15_ENST00000309283.7_Missense_Mutation_p.H130Y|SLC6A15_ENST00000552192.1_Missense_Mutation_p.H315Y	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	422					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						GAATTGAGATGAAGAGCAGGA	0.308000													20	36					0	0	0.001523	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33643537	33643537	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:33643537A>G	ENST00000504830.1	-	10	1853	c.1518T>C	c.(1516-1518)ttT>ttC	p.F506F	ADAMTS12_ENST00000352040.3_Silent_p.F506F|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	506	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TAGAGCGACAAAAGCCCTTCA	0.498000										HNSCC(64;0.19)			28	79					0	0	0.001786	0	0
RGL2	5863	broad.mit.edu	37	6	33262943	33262943	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:33262943C>T	ENST00000497454.1	-	9	1665	c.1170G>A	c.(1168-1170)gaG>gaA	p.E390E	RGL2_ENST00000444031.2_Silent_p.E308E|PFDN6_ENST00000463584.1_Intron|RGL2_ENST00000437840.2_5'UTR	NM_001243738.1|NM_004761.4	NP_001230667.1|NP_004752.1	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation stimulator-like 2	390	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			breast(2)|cervix(2)|endometrium(7)|kidney(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	34						AATTATCCTCCTCGGAGAAAA	0.577000													4	23					0	0	0.000248	0	0
OR52I2	143502	broad.mit.edu	37	11	4608507	4608507	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:4608507C>T	ENST00000312614.4	+	1	487	c.465C>T	c.(463-465)gcC>gcT	p.A155A		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTATGTAGCCATCTGCAAGC	0.488000													7	76					0	0	0.000443	0	0
PDE1C	5137	broad.mit.edu	37	7	31917614	31917614	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:31917614C>G	ENST00000396184.3	-	6	665	c.461G>C	c.(460-462)aGc>aCc	p.S154T	PDE1C_ENST00000396182.2_Missense_Mutation_p.S154T|PDE1C_ENST00000396193.1_Missense_Mutation_p.S214T|PDE1C_ENST00000396191.1_Missense_Mutation_p.S154T|PDE1C_ENST00000321453.7_Missense_Mutation_p.S154T	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	154					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			TGGTGGATAGCTCAGTCCAAC	0.338000													6	28					0	0	0.004482	0	0
CRX	1406	broad.mit.edu	37	19	48339545	48339545	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:48339545G>A	ENST00000221996.7	+	3	352	c.146G>A	c.(145-147)aGc>aAc	p.S49N	CRX_ENST00000539067.1_Missense_Mutation_p.S49N|TPRX2P_ENST00000535362.1_Intron	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	49					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		TTCACCCGGAGCCAACTGGAG	0.632000													22	58					0	0	0.001523	0	0
TSPAN32	10077	broad.mit.edu	37	11	2335755	2335755	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:2335755G>C	ENST00000182290.4	+	6	634	c.497G>C	c.(496-498)gGg>gCg	p.G166A	TSPAN32_ENST00000451520.2_Missense_Mutation_p.G155A|TSPAN32_ENST00000483227.1_3'UTR|TSPAN32_ENST00000381121.3_Missense_Mutation_p.G166A	NM_139022.2	NP_620591.3	Q96QS1	TSN32_HUMAN	tetraspanin 32	166					cell-cell signaling	integral to membrane				breast(1)|central_nervous_system(1)|lung(4)|ovary(1)|skin(1)	8		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		AGCCGTCTGGGGAGCACAGAG	0.647000													3	10					0	0	0.004672	0	0
LRRN3	54674	broad.mit.edu	37	7	110762957	110762957	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:110762957C>A	ENST00000451085.1	+	4	1175	c.129C>A	c.(127-129)ccC>ccA	p.P43P	IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000331762.3_Intron|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000450877.1_Intron|IMMP2L_ENST00000415362.1_Intron|LRRN3_ENST00000308478.5_Silent_p.P43P|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000437687.1_Intron|LRRN3_ENST00000422987.3_Silent_p.P43P|IMMP2L_ENST00000447215.1_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	43	LRRNT.					integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		GGTTTACACCCAGATCCATTT	0.413000													27	80					1.26454e-06	2.24596e-06	0.005443	1	0
HTRA1	5654	broad.mit.edu	37	10	124266322	124266322	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:124266322G>T	ENST00000368984.3	+	4	1021	c.893G>T	c.(892-894)aGc>aTc	p.S298I		NM_002775.4	NP_002766.1	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1	298	Serine protease.				proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(8)|lung(7)	17		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				GGGATCGTGAGCACCACCCAG	0.622000													25	75					8.24728e-16	1.82495e-15	0.004656	1	0
IDS	3423	broad.mit.edu	37	X	148564745	148564745	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:148564745C>A	ENST00000340855.6	-	9	1394	c.1185G>T	c.(1183-1185)agG>agT	p.R395S	AF011889.5_ENST00000422081.1_RNA|IDS_ENST00000541269.1_Missense_Mutation_p.R184S|IDS_ENST00000537071.1_5'UTR	NM_000202.5|NM_001166550.1	NP_000193.1|NP_001160022.1	P22304	IDS_HUMAN	iduronate 2-sulfatase	395						lysosome	iduronate-2-sulfatase activity|metal ion binding			NS(1)|breast(3)|endometrium(5)|large_intestine(2)|lung(8)|prostate(1)	20	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CCATGGATTGCCTGCCTGAAA	0.532000													11	9					4.68919e-08	8.65e-08	0.000673	1	0
CLIP1	6249	broad.mit.edu	37	12	122825411	122825411	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:122825411C>T	ENST00000358808.2	-	10	2461	c.2307G>A	c.(2305-2307)cgG>cgA	p.R769R	CLIP1_ENST00000361654.4_Intron|CLIP1_ENST00000545889.1_Intron|CLIP1_ENST00000540338.1_Silent_p.R780R|CLIP1_ENST00000537178.1_Silent_p.R734R|CLIP1_ENST00000302528.7_Silent_p.R769R	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	780					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		AACTGGCTTTCCGAAGTGCAT	0.393000													45	99					0	0	0.002222	0	0
FBN3	84467	broad.mit.edu	37	19	8206824	8206824	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:8206824C>A	ENST00000600128.1	-	7	1153	c.739_splice	c.e7+1	p.D247_splice	FBN3_ENST00000270509.2_Splice_Site_p.D247_splice|FBN3_ENST00000601739.1_Splice_Site_p.D247_splice			Q75N90	FBN3_HUMAN	fibrillin 3	247	EGF-like 2; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CACTATTCACCTTGGCAGGCC	0.637000													14	47					1.5842e-08	2.96042e-08	0.001855	1	0
GXYLT2	727936	broad.mit.edu	37	3	73004273	73004273	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:73004273C>A	ENST00000389617.4	+	4	786	c.625C>A	c.(625-627)Ctt>Att	p.L209I		NM_001080393.1	NP_001073862.1	A0PJZ3	GXLT2_HUMAN	glucoside xylosyltransferase 2	209					O-glycan processing	integral to membrane	UDP-xylosyltransferase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	18						TGTGGACTCACTTCTCTACGT	0.468000													13	15					5.50884e-06	9.56422e-06	0.001368	1	0
CST5	1473	broad.mit.edu	37	20	23860133	23860133	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23860133T>A	ENST00000304710.4	-	1	254	c.181A>T	c.(181-183)Aag>Tag	p.K61*		NM_001900.4	NP_001891.2	P28325	CYTD_HUMAN	cystatin D	61						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|stomach(1)	11						TACTCATCCTTATTAATGACC	0.557000													70	224					0	0	0.003610	0	0
LRRTM4	80059	broad.mit.edu	37	2	77746849	77746849	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:77746849G>T	ENST00000409088.3	-	3	560	c.146C>A	c.(145-147)tCt>tAt	p.S49Y	LRRTM4_ENST00000409911.1_Missense_Mutation_p.S50Y|LRRTM4_ENST00000409884.1_Missense_Mutation_p.S49Y|LRRTM4_ENST00000409282.1_Missense_Mutation_p.S50Y|LRRTM4_ENST00000409093.1_Missense_Mutation_p.S49Y	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	49	LRRNT.					integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		GAAAGCATGAGACTCACAGTA	0.463000													27	72					1.17739e-12	2.39901e-12	0.005443	1	0
CDC34	997	broad.mit.edu	37	19	541375	541375	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:541375T>C	ENST00000215574.4	+	5	752	c.534T>C	c.(532-534)cgT>cgC	p.R178R		NM_004359.1	NP_004350.1	P49427	UB2R1_HUMAN	cell division cycle 34	178					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(1)	2		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCGGAGCGTGACGGCGTGA	0.706000													6	11					0	0	0.001984	0	0
OR4L1	122742	broad.mit.edu	37	14	20528986	20528986	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20528986A>G	ENST00000315683.1	+	1	783	c.783A>G	c.(781-783)ccA>ccG	p.P261P		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		ATGTTTGGCCATTCAGTAGTT	0.403000													23	87					0	0	0.002780	0	0
CCL8	6355	broad.mit.edu	37	17	32646545	32646545	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:32646545T>C	ENST00000394620.1	+	1	491	c.25T>C	c.(25-27)Tgc>Cgc	p.C9R		NM_005623.2	NP_005614.2	P80075	CCL8_HUMAN	chemokine (C-C motif) ligand 8	9					calcium ion transport|cell-cell signaling|chemotaxis|exocytosis|immune response|inflammatory response|response to virus	extracellular space	chemokine activity|heparin binding|signal transducer activity			NS(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Ovarian(249;0.0443)|Breast(31;0.151)				AGCGCTTCTGTGCCTGCTGCT	0.527000													35	49					0	0	0.005524	0	0
KRTAP1-3	81850	broad.mit.edu	37	17	39190992	39190992	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:39190992T>C	ENST00000344363.5	-	1	115	c.82A>G	c.(82-84)Agc>Ggc	p.S28G		NM_030966.1	NP_112228.1	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	28						extracellular region|keratin filament	structural constituent of epidermis			cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(6)	12		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TCACAGCAGCTTGGCTGGCAG	0.597000													34	57					0	0	0.003755	0	0
HTR1E	3354	broad.mit.edu	37	6	87725582	87725582	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:87725582A>T	ENST00000305344.4	+	2	1233	c.530A>T	c.(529-531)cAc>cTc	p.H177L	HTR1E_ENST00000369584.1_Missense_Mutation_p.H177L	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	177					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	ACCATCCAGCACGACCATGTT	0.522000													19	69					0	0	0.000958	0	0
MYO1C	4641	broad.mit.edu	37	17	1386207	1386207	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:1386207T>G	ENST00000359786.5	-	4	818	c.494A>C	c.(493-495)gAg>gCg	p.E165A	MYO1C_ENST00000438665.2_Missense_Mutation_p.E146A|MYO1C_ENST00000575158.1_Missense_Mutation_p.E130A|MYO1C_ENST00000361007.2_Missense_Mutation_p.E130A|MYO1C_ENST00000545534.2_Missense_Mutation_p.E141A	NM_001080779.1	NP_001074248.1	O00159	MYO1C_HUMAN	myosin IC	165	Myosin head-like.			E -> Q (in Ref. 1; CAA67131).	mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		ACCTCCGCGCTCGGGGGCTGG	0.692000													13	30					0	0	0.001855	0	0
PRKCG	5582	broad.mit.edu	37	19	54401341	54401341	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54401341T>C	ENST00000536044.1	+	9	1276	c.980T>C	c.(979-981)tTc>tCc	p.F327S	PRKCG_ENST00000540413.1_Silent_p.V356V|PRKCG_ENST00000263431.3_Silent_p.V356V|PRKCG_ENST00000542049.1_Silent_p.V243V			P05129	KPCG_HUMAN	protein kinase C, gamma	0					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TCCTCATGGTTCTAGGAAAAG	0.572000													19	42					0	0	0.006122	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107069363	107069363	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:107069363C>T	ENST00000539449.1	-	3	908	c.432G>A	c.(430-432)tgG>tgA	p.W144*	RTN4IP1_ENST00000369063.3_Nonsense_Mutation_p.W144*			Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1	144						mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		GAACTGCAGCCCAGACCTGAA	0.418000													26	95					0	0	0.005443	0	0
TRMT1L	81627	broad.mit.edu	37	1	185114616	185114616	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:185114616T>A	ENST00000367504.3	-	5	881	c.142A>T	c.(142-144)Agg>Tgg	p.R48W	TRMT1L_ENST00000367506.5_Missense_Mutation_p.R204W			Q7Z2T5	TRM1L_HUMAN	tRNA methyltransferase 1 homolog (S. cerevisiae)-like	204						intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	21						ATGTGGCGCCTAACATGTCCT	0.343000													20	61					0	0	0.001882	0	0
NES	10763	broad.mit.edu	37	1	156642721	156642721	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:156642721C>A	ENST00000368223.3	-	4	1391	c.1259G>T	c.(1258-1260)gGg>gTg	p.G420V		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	420	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGTTTCCTCCCACCCTGTGT	0.657000													24	67					4.47668e-21	1.06961e-20	0.003954	1	0
CYLC2	1539	broad.mit.edu	37	9	105765547	105765547	+	Splice_Site	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:105765547T>C	ENST00000374798.3	+	3	250		c.e3+2		CYLC2_ENST00000487798.1_Splice_Site	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2						cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				ACGGTTTCTGTAAGCATTGGA	0.323000													16	52					0	0	0.004007	0	0
COL19A1	1310	broad.mit.edu	37	6	70859624	70859624	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:70859624G>T	ENST00000322773.4	+	28	2024	c.1922G>T	c.(1921-1923)gGt>gTt	p.G641V	COL19A1_ENST00000393344.1_Missense_Mutation_p.G263V	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	641	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						GGAGAGCCAGGTATTCAGGTA	0.383000													13	34					0.00244969	0.00398423	0.002450	1	0
FAT3	120114	broad.mit.edu	37	11	92533403	92533403	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:92533403C>G	ENST00000298047.6	+	9	7241	c.7224C>G	c.(7222-7224)ccC>ccG	p.P2408P	FAT3_ENST00000525166.1_Silent_p.P2258P|FAT3_ENST00000409404.2_Silent_p.P2408P			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2408	Cadherin 22.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.P2408P(2)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AATTAGCCCCCCGGGGCCATT	0.443000										TCGA Ovarian(4;0.039)			42	89					0	0	0.001706	0	0
SIM1	6492	broad.mit.edu	37	6	100838661	100838661	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:100838661T>A	ENST00000369208.3	-	12	2659	c.1877A>T	c.(1876-1878)aAc>aTc	p.N626I	SIM1_ENST00000262901.4_Missense_Mutation_p.N626I			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	626	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TGGTGAAGTGTTGGCAAGAGC	0.493000													53	123					0	0	0.003610	0	0
PACS1	55690	broad.mit.edu	37	11	66003368	66003368	+	Splice_Site	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:66003368G>A	ENST00000320580.4	+	19	2240		c.e19-1		PACS1_ENST00000529757.1_Splice_Site	NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1						interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						TCTCCCAACAGCCCTGATGAA	0.532000													37	115					0	0	0.001287	0	0
ABCA13	154664	broad.mit.edu	37	7	48443395	48443395	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:48443395G>T	ENST00000435803.1	+	39	12013	c.11989G>T	c.(11989-11991)Gtg>Ttg	p.V3997L		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3997	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GTCGAGGACCGTGGTTCTGGA	0.572000													9	25					1.76689e-08	3.29568e-08	0.000443	1	0
ZNF286B	729288	broad.mit.edu	37	17	18565409	18565409	+	Silent	SNP	A	A	G	rs143494999	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:18565409A>G	ENST00000545289.1	-	5	1660	c.1410T>C	c.(1408-1410)agT>agC	p.S470S		NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	470					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						TTCCACACTCACTACATTTGT	0.393000													3	36					0	0	0.004482	0	0
DYSF	8291	broad.mit.edu	37	2	71797809	71797809	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:71797809C>T	ENST00000258104.3	+	29	3389	c.3112C>T	c.(3112-3114)Cga>Tga	p.R1038*	DYSF_ENST00000409651.1_Nonsense_Mutation_p.R1070*|DYSF_ENST00000410041.1_Nonsense_Mutation_p.R1056*|DYSF_ENST00000409366.1_Nonsense_Mutation_p.R1039*|DYSF_ENST00000429174.2_Nonsense_Mutation_p.R1038*|DYSF_ENST00000409762.1_Nonsense_Mutation_p.R1055*|DYSF_ENST00000394120.2_Nonsense_Mutation_p.R1039*|DYSF_ENST00000410020.3_Nonsense_Mutation_p.R1056*|DYSF_ENST00000413539.2_Nonsense_Mutation_p.R1069*|DYSF_ENST00000409744.1_Nonsense_Mutation_p.R1025*|DYSF_ENST00000409582.3_Nonsense_Mutation_p.R1055*	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1038	Arg-rich.		R -> Q (in LGMD2B; uncertain pathogenicity).			cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CTACACACACCGACGGCGGCG	0.642000													14	32					0	0	0.002450	0	0
GPR32	2854	broad.mit.edu	37	19	51274592	51274592	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:51274592G>T	ENST00000270590.4	+	1	872	c.735G>T	c.(733-735)cgG>cgT	p.R245R		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	245						integral to plasma membrane	N-formyl peptide receptor activity			breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		AGCTCTTGCGGGAGGGCTGGG	0.602000													20	49					4.63292e-17	1.03891e-16	0.001216	1	0
PRKAB1	5564	broad.mit.edu	37	12	120114377	120114377	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:120114377G>T	ENST00000229328.5	+	5	1060	c.568G>T	c.(568-570)Gag>Tag	p.E190*	PRKAB1_ENST00000540121.1_Nonsense_Mutation_p.E24*|PRKAB1_ENST00000541640.1_Nonsense_Mutation_p.E190*	NM_006253.4	NP_006244.2	Q9Y478	AAKB1_HUMAN	protein kinase, AMP-activated, beta 1 non-catalytic subunit	190					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol				endometrium(2)|large_intestine(3)|lung(5)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	CTACCATCAGGAGCCCTACGT	0.537000													36	80					9.80977e-26	2.42765e-25	0.004289	1	0
UGGT2	55757	broad.mit.edu	37	13	96599374	96599374	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:96599374C>T	ENST00000376747.3	-	15	1664	c.1594G>A	c.(1594-1596)Gat>Aat	p.D532N		NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	532					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						ACTCCAGCATCATTTGCTCCA	0.343000													23	33					0	0	0.002299	0	0
USP4	7375	broad.mit.edu	37	3	49377429	49377429	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:49377429C>G	ENST00000351842.4	-	1	37	c.29G>C	c.(28-30)cGa>cCa	p.R10P	USP4_ENST00000265560.4_Missense_Mutation_p.R10P|USP4_ENST00000416417.1_Missense_Mutation_p.R10P|USP4_ENST00000415188.1_Missense_Mutation_p.R10P	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	10					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		CGCATCCGGTCGCTCACGGCA	0.697000													6	24					0	0	0.001168	0	0
TNN	63923	broad.mit.edu	37	1	175049390	175049390	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:175049390C>A	ENST00000239462.4	+	4	989	c.876C>A	c.(874-876)ctC>ctA	p.L292L		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	292	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ATCACTACCTCCTCAGCTACT	0.592000													18	37					5.3912e-06	9.37621e-06	0.006122	1	0
SCAF4	57466	broad.mit.edu	37	21	33064243	33064243	+	Splice_Site	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:33064243T>C	ENST00000286835.7	-	14	1997	c.1614_splice	c.e14-1	p.M539_splice	SCAF4_ENST00000434667.3_Splice_Site_p.M524_splice|SCAF4_ENST00000399804.1_Splice_Site_p.M539_splice	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	539	RRM.					nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						GGAGGAATCATCTGCTCCAAA	0.408000													17	52					0	0	0.004990	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29974575	29974575	+	RNA	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:29974575A>C	ENST00000376797.3	-	0	1346				ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA																							CCTCGCCCCCAGGCTCCCACT	0.711000													4	45					0	0	0.000248	0	0
CREG2	200407	broad.mit.edu	37	2	102000150	102000150	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:102000150T>C	ENST00000324768.4	-	2	593	c.456A>G	c.(454-456)ccA>ccG	p.P152P	CREG2_ENST00000495455.1_5'UTR	NM_153836.3	NP_722578.1	Q8IUH2	CREG2_HUMAN	cellular repressor of E1A-stimulated genes 2	152						extracellular region	FMN binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	10						AGTTCCCAAATGGCAGTCCTT	0.512000													34	77					0	0	0.003271	0	0
KIF4B	285643	broad.mit.edu	37	5	154394597	154394597	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:154394597A>T	ENST00000435029.4	+	1	1338	c.1178A>T	c.(1177-1179)cAg>cTg	p.Q393L		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	393					axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GAGAAGAATCAGTCCCTGGTA	0.468000													33	100					0	0	0.001786	0	0
PLCB3	5331	broad.mit.edu	37	11	64022704	64022704	+	Splice_Site	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:64022704A>T	ENST00000540288.1	+	5	490		c.e5-1		PLCB3_ENST00000325234.5_Splice_Site|PLCB3_ENST00000279230.6_Splice_Site	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)						intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						CTGGCCCCCCAGGTCTGGTCT	0.627000													8	10					0	0	0.000673	0	0
ABCA3	21	broad.mit.edu	37	16	2329015	2329015	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:2329015C>T	ENST00000301732.5	-	29	5176	c.4476G>A	c.(4474-4476)ggG>ggA	p.G1492G	ABCA3_ENST00000382381.3_Silent_p.G1434G	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	1492	ABC transporter 2.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				CCACGCAGGCCCCGATGTGGC	0.652000													41	104					0	0	0.001287	0	0
F7	2155	broad.mit.edu	37	13	113770072	113770072	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:113770072G>T	ENST00000375581.3	+	6	564	c.529G>T	c.(529-531)Ggg>Tgg	p.G177W	F7_ENST00000346342.3_Missense_Mutation_p.G155W|F7_ENST00000541084.1_Missense_Mutation_p.G108W	NM_000131.4	NP_000122.1	P08709	FA7_HUMAN	coagulation factor VII (serum prothrombin conversion accelerator)	177	EGF-like 2.		G -> R (in FA7D).		anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity			large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	GTGCCACGAGGGGTACTCTCT	0.602000													7	24					0.00198382	0.00323176	0.001984	1	0
ANO4	121601	broad.mit.edu	37	12	101491468	101491468	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:101491468C>A	ENST00000392979.3	+	19	2146	c.1785C>A	c.(1783-1785)aaC>aaA	p.N595K	ANO4_ENST00000299222.9_Missense_Mutation_p.N150K|ANO4_ENST00000392977.3_Missense_Mutation_p.N630K|ANO4_ENST00000550015.1_Missense_Mutation_p.N150K	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	630						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						GGCTGATAAACAGGTGGAGAC	0.428000										HNSCC(74;0.22)			20	52					2.39556e-15	5.20335e-15	0.002780	1	0
CACNA1D	776	broad.mit.edu	37	3	53781378	53781378	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:53781378C>A	ENST00000288139.3	+	27	3395	c.3277C>A	c.(3277-3279)Cgt>Agt	p.R1093S	CACNA1D_ENST00000350061.5_Missense_Mutation_p.R1073S|CACNA1D_ENST00000422281.2_Missense_Mutation_p.R1073S	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1073	Dihydropyridine binding (By similarity).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TCCTGTGGTCCGTGAACGGAT	0.527000													43	42					4.16155e-14	8.80108e-14	0.001951	1	0
PIWIL1	9271	broad.mit.edu	37	12	130831562	130831562	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:130831562C>A	ENST00000245255.3	+	6	880	c.608C>A	c.(607-609)cCt>cAt	p.P203H		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	203					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GAACTTCCACCTACATCACCA	0.348000													17	36					6.94344e-10	1.34642e-09	0.006122	1	0
CWF19L2	143884	broad.mit.edu	37	11	107224343	107224343	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:107224343C>A	ENST00000282251.5	-	13	2019	c.1992G>T	c.(1990-1992)gaG>gaT	p.E664D	CWF19L2_ENST00000433523.1_Missense_Mutation_p.E664D	NM_152434.2	NP_689647.2	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control (S. pombe)	664							catalytic activity			endometrium(4)|kidney(2)|large_intestine(13)|lung(21)	40		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		GACTCCGATGCTCAGCAATAG	0.413000													24	53					2.21704e-12	4.48096e-12	0.002780	1	0
SPN	6693	broad.mit.edu	37	16	29675891	29675891	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:29675891A>C	ENST00000360121.3	+	2	934	c.842A>C	c.(841-843)cAg>cCg	p.Q281P	SPN_ENST00000395389.2_Missense_Mutation_p.Q281P|AC009133.19_ENST00000449759.1_Intron	NM_001030288.2|NM_003123.4	NP_001025459.1|NP_003114.1	P16150	LEUK_HUMAN	sialophorin	281					blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|stomach(1)	15						CGCCGGCGGCAGAAGCGGCGG	0.697000													8	20					0	0	0.003080	0	0
DBX2	440097	broad.mit.edu	37	12	45429829	45429829	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:45429829G>C	ENST00000332700.6	-	2	643	c.472C>G	c.(472-474)Cgc>Ggc	p.R158G		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	158						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		gatgcagggcgccgacaggac	0.493000													6	13					0	0	0.001168	0	0
FRMPD1	22844	broad.mit.edu	37	9	37745967	37745967	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:37745967C>A	ENST00000539465.1	+	16	4531	c.3938C>A	c.(3937-3939)gCc>gAc	p.A1313D	FRMPD1_ENST00000377765.3_Missense_Mutation_p.A1313D|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1313						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CTCAGGGTGGCCACATCTTTG	0.532000													33	91					1.08312e-15	2.37576e-15	0.001786	1	0
IFI44L	10964	broad.mit.edu	37	1	79106756	79106756	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:79106756C>A	ENST00000370751.4	+	7	1278	c.1099C>A	c.(1099-1101)Ctt>Att	p.L367I	IFI44L_ENST00000342282.3_Missense_Mutation_p.L109I|IFI44L_ENST00000476521.1_3'UTR	NM_006820.2	NP_006811.2	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	367						cytoplasm				endometrium(4)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	22						CAGTGAGGTTCTTCAAGACAA	0.313000													61	34					1.46168e-27	3.6262e-27	0.003610	1	0
ANKZF1	55139	broad.mit.edu	37	2	220095004	220095004	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:220095004C>T	ENST00000323348.5	+	2	199	c.25C>T	c.(25-27)Ccg>Tcg	p.P9S	ANKZF1_ENST00000410034.3_Missense_Mutation_p.P9S|ANKZF1_ENST00000409849.1_Intron	NM_018089.2	NP_060559.2	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing 1	9						intracellular	zinc ion binding			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	23		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGATGCAGCCCCGGCTCCTGC	0.612000													11	22					0	0	0.001368	0	0
SAMD3	154075	broad.mit.edu	37	6	130535481	130535481	+	Splice_Site	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:130535481C>T	ENST00000532763.1	-	3	399		c.e3+1		SAMD3_ENST00000324172.6_Splice_Site|SAMD3_ENST00000457563.2_Splice_Site|SAMD3_ENST00000439090.2_Splice_Site|SAMD3_ENST00000437477.2_Splice_Site|SAMD3_ENST00000368134.2_Splice_Site|SAMD3_ENST00000533296.1_Splice_Site			Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3											breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		AACATACTCACTCTCGAGCTG	0.433000													25	68					0	0	0.005443	0	0
NLRC4	58484	broad.mit.edu	37	2	32475967	32475967	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:32475967C>T	ENST00000404025.2	-	5	1454	c.966G>A	c.(964-966)ttG>ttA	p.L322L	NLRC4_ENST00000360906.5_Silent_p.L322L|NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000402280.1_Silent_p.L322L			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	322	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GAATTTGGAGCAACAAGCCTT	0.507000													18	51					0	0	0.006122	0	0
PSG2	5670	broad.mit.edu	37	19	43585036	43585036	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:43585036A>G	ENST00000406487.1	-	2	525	c.427T>C	c.(427-429)Tac>Cac	p.Y143H		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	143	Ig-like V-type.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				CACTTACGGTATAAGGTGAAG	0.507000													37	131					0	0	0.003610	0	0
FLRT2	23768	broad.mit.edu	37	14	86088278	86088278	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:86088278G>C	ENST00000330753.4	+	2	1187	c.420G>C	c.(418-420)ctG>ctC	p.L140L	FLRT2_ENST00000554746.1_Silent_p.L140L	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	140					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		AGCTGCACCTGGATGACAACT	0.488000													16	55					0	0	0.003163	0	0
KIAA1429	25962	broad.mit.edu	37	8	95543280	95543280	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:95543280C>A	ENST00000297591.5	-	6	593	c.518G>T	c.(517-519)aGc>aTc	p.S173I	KIAA1429_ENST00000421249.2_Missense_Mutation_p.S173I|KIAA1429_ENST00000437199.1_Missense_Mutation_p.S173I	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	173	Pro-rich.				mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TCTTGGAGGGCTTCCATTAAA	0.463000													11	46					1.08611e-07	1.98346e-07	0.000978	1	0
ZDBF2	57683	broad.mit.edu	37	2	207176110	207176110	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:207176110G>T	ENST00000374423.3	+	5	7244	c.6858G>T	c.(6856-6858)atG>atT	p.M2286I		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2286							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						CAAGCGCTATGGCAAATCCTC	0.507000													8	4					0.000274275	0.000453435	0.004482	1	0
ACKR4	51554	broad.mit.edu	37	3	132319825	132319825	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:132319825C>G	ENST00000249887.2	+	2	680	c.584C>G	c.(583-585)tCa>tGa	p.S195*	ACAD11_ENST00000264990.6_Intron|ACAD11_ENST00000355458.3_Intron|ACAD11_ENST00000545291.1_Intron	NM_016557.2|NM_178445.2	NP_057641.1|NP_848540.1			atypical chemokine receptor 4																		CTAGGAACATCAATGAAAGCA	0.433000													3	52					0	0	0.003080	0	0
METTL1	4234	broad.mit.edu	37	12	58163103	58163103	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:58163103C>A	ENST00000324871.7	-	5	1367	c.658G>T	c.(658-660)Gtg>Ttg	p.V220L	METTL1_ENST00000257848.7_3'UTR	NM_005371.5	NP_005362.3	Q9UBP6	TRMB_HUMAN	methyltransferase like 1	220						cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding			large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	4	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)			TCCAGAGGCACACGCTCAAAC	0.537000													11	21					3.86212e-05	6.52464e-05	0.000673	1	0
PIP5K1C	23396	broad.mit.edu	37	19	3653452	3653452	+	Missense_Mutation	SNP	C	C	G	rs121908315		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:3653452C>G	ENST00000335312.3	-	7	845	c.757G>C	c.(757-759)Gac>Cac	p.D253H	PIP5K1C_ENST00000589578.1_Missense_Mutation_p.D253H|PIP5K1C_ENST00000587482.1_5'UTR|PIP5K1C_ENST00000539785.1_Missense_Mutation_p.D253H|PIP5K1C_ENST00000537021.1_Missense_Mutation_p.D253H	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	253	PIPK.		D -> N (in LCCS3; loss of activity).		axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		CCCTTGAGGTCGAACTTGAGG	0.587000													21	61					0	0	0.002299	0	0
OGDHL	55753	broad.mit.edu	37	10	50966454	50966454	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:50966454T>A	ENST00000374103.4	-	2	270	c.185A>T	c.(184-186)aAc>aTc	p.N62I	OGDHL_ENST00000432695.1_Intron|OGDHL_ENST00000419399.1_Missense_Mutation_p.N62I	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	62					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						ACTCTGGGGGTTTTCCAACCA	0.662000													31	92					0	0	0.002096	0	0
PKD1	5310	broad.mit.edu	37	16	2159077	2159077	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:2159077C>A	ENST00000262304.4	-	15	6299	c.6091G>T	c.(6091-6093)Gtg>Ttg	p.V2031L	PKD1_ENST00000423118.1_Missense_Mutation_p.V2031L	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	2031	PKD 16.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CCCGCGGCCACGGGCGTGTAG	0.677000													45	48					2.215e-12	4.48096e-12	0.002852	1	0
DOCK1	1793	broad.mit.edu	37	10	129224216	129224216	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:129224216G>A	ENST00000280333.6	+	47	4901	c.4792G>A	c.(4792-4794)Gag>Aag	p.E1598K		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1598	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CGAGAGGATGGAGGCCTGTTT	0.507000													71	152					0	0	0.003610	0	0
OR4K14	122740	broad.mit.edu	37	14	20482729	20482729	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20482729G>C	ENST00000305045.2	-	1	623	c.624C>G	c.(622-624)tcC>tcG	p.S208S		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	208					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		AACAGCTCAAGGAAAGCAACC	0.502000													13	32					0	0	0.002450	0	0
NXPE1	120400	broad.mit.edu	37	11	114401134	114401134	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:114401134C>T	ENST00000536312.1	-	6	1488	c.596G>A	c.(595-597)gGc>gAc	p.G199D	NXPE1_ENST00000251921.2_Missense_Mutation_p.G57D|NXPE1_ENST00000424269.1_Missense_Mutation_p.G199D					neurexophilin and PC-esterase domain family, member 1																		TTTATCATAGCCTTGGTTCCT	0.498000													21	61					0	0	0.001216	0	0
ADCY2	108	broad.mit.edu	37	5	7789793	7789793	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:7789793C>A	ENST00000338316.4	+	20	2597	c.2508C>A	c.(2506-2508)aaC>aaA	p.N836K	ADCY2_ENST00000537121.1_Missense_Mutation_p.N656K	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	836					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TATGGAAGAACAAATTCAAAA	0.483000													26	93					2.12542e-12	4.31315e-12	0.001061	1	0
SLC8A1	6546	broad.mit.edu	37	2	40656936	40656936	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:40656936G>T	ENST00000406785.1	-	2	674	c.485C>A	c.(484-486)aCt>aAt	p.T162N	SLC8A1_ENST00000406391.2_Missense_Mutation_p.T162N|SLC8A1_ENST00000408028.2_Missense_Mutation_p.T162N|SLC8A1_ENST00000405269.1_Missense_Mutation_p.T162N|SLC8A1_ENST00000403092.1_Missense_Mutation_p.T162N|SLC8A1_ENST00000402441.1_Missense_Mutation_p.T162N|SLC8A1_ENST00000332839.4_Missense_Mutation_p.T162N|SLC8A1_ENST00000542756.1_Missense_Mutation_p.T162N|SLC8A1_ENST00000542024.1_Missense_Mutation_p.T162N|SLC8A1_ENST00000405901.3_Missense_Mutation_p.T162N			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	162					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GTCTCCTGCAGTGAAGTTATG	0.468000													20	57					1.56452e-12	3.17814e-12	0.000958	1	0
OVCH1	341350	broad.mit.edu	37	12	29631793	29631793	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:29631793T>C	ENST00000318184.5	-	9	1043	c.1044A>G	c.(1042-1044)ttA>ttG	p.L348L	OVCH1-AS1_ENST00000551108.1_Intron|OVCH1-AS1_ENST00000549411.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	348	CUB 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TGCTTGATCGTAAAGATACAT	0.303000													8	25					0	0	0.004482	0	0
CSAG4	100130935	broad.mit.edu	37	X	151896605	151896605	+	RNA	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:151896605C>T	ENST00000361201.4	-	0	335					NR_073432.1															endometrium(2)|kidney(2)|lung(1)	5						GCTGGAGGCTCGTGGTTTCCT	0.552000													62	46					0	0	0.003610	0	0
BANK1	55024	broad.mit.edu	37	4	102951361	102951361	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:102951361C>A	ENST00000504592.1	+	14	2212	c.1794C>A	c.(1792-1794)gcC>gcA	p.A598A	BANK1_ENST00000428908.1_Silent_p.A480A|RP11-498M5.2_ENST00000505091.1_RNA|BANK1_ENST00000508653.1_Silent_p.A480A|BANK1_ENST00000322953.4_Silent_p.A613A|BANK1_ENST00000444316.2_Silent_p.A583A			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	613					B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		GACCTCCTGCCCCCACACCCC	0.373000													25	48					6.32553e-13	1.29677e-12	0.004656	1	0
PCDH11Y	83259	broad.mit.edu	37	Y	4924812	4924812	+	Translation_Start_Site	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:4924812A>T	ENST00000362095.5	+	0	682				PCDH11Y_ENST00000333703.4_Intron	NM_032972.2	NP_116754.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						AGTGTCAATTATGCTAACATC	0.269000													15	11					0	0	0.006122	0	0
RAB7A	7879	broad.mit.edu	37	3	128516832	128516832	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:128516832A>C	ENST00000265062.3	+	3	346	c.100A>C	c.(100-102)Agc>Cgc	p.S34R	RAB7A_ENST00000485280.1_Missense_Mutation_p.S34R|RAB7A_ENST00000482525.1_Missense_Mutation_p.S34R	NM_004637.5	NP_004628.4	P51149	RAB7A_HUMAN	RAB7A, member RAS oncogene family	34					endocytosis|endosome to lysosome transport|epidermal growth factor catabolic process|protein transport|small GTPase mediated signal transduction	Golgi apparatus|late endosome|lysosome|melanosome|phagocytic vesicle	GDP binding|GTP binding|GTPase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	8				GBM - Glioblastoma multiforme(114;0.231)		TAAGAAATTCAGCAATCAGTA	0.433000													30	109					0	0	0.001271	0	0
PIK3R4	30849	broad.mit.edu	37	3	130442379	130442379	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:130442379C>G	ENST00000356763.3	-	7	2417	c.1860G>C	c.(1858-1860)ctG>ctC	p.L620L		NM_014602.2	NP_055417.1	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	620					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(6)|large_intestine(16)|lung(28)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	77						GACCTTGTTGCAGCAGAGGCT	0.408000													29	36					0	0	0.001061	0	0
OR5D16	390144	broad.mit.edu	37	11	55606250	55606250	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55606250C>A	ENST00000378396.1	+	1	23	c.23C>A	c.(22-24)aCg>aAg	p.T8K		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				GAGAGAAATACGACATCTGAG	0.413000													22	42					1.36565e-18	3.15403e-18	0.002780	1	0
MEFV	4210	broad.mit.edu	37	16	3306443	3306443	+	Silent	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:3306443T>G	ENST00000219596.1	-	1	184	c.145A>C	c.(145-147)Agg>Cgg	p.R49R	MEFV_ENST00000339854.4_Silent_p.R49R|MEFV_ENST00000541159.1_Silent_p.R49R|MEFV_ENST00000536379.1_Silent_p.R49R	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	49	DAPIN.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	TTCACCGGCCTGGCTCTCTGG	0.602000													68	85					0	0	0.003610	0	0
DYRK2	8445	broad.mit.edu	37	12	68051900	68051900	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:68051900A>T	ENST00000344096.3	+	3	1626	c.1213A>T	c.(1213-1215)Atg>Ttg	p.M405L	DYRK2_ENST00000393555.3_Missense_Mutation_p.M332L	NM_006482.2	NP_006473.2	Q92630	DYRK2_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	405	Protein kinase.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|positive regulation of glycogen biosynthetic process|smoothened signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|manganese ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	30			Lung(24;6.81e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(7;0.000573)		GCCCATTGATATGTGGAGCCT	0.542000													11	30					0	0	0.000673	0	0
ZNF394	84124	broad.mit.edu	37	7	99097390	99097390	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:99097390C>T	ENST00000337673.6	-	1	530	c.327G>A	c.(325-327)ctG>ctA	p.L109L	ZNF789_ENST00000494186.1_Intron|ZNF394_ENST00000394177.3_5'UTR|ZNF789_ENST00000493485.1_Intron|ZNF394_ENST00000426306.2_Silent_p.L109L	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	109	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GGAACTGCTCCAGCACCAGCA	0.672000													5	134					0	0	0.001984	0	0
SLC38A9	153129	broad.mit.edu	37	5	54945036	54945036	+	Splice_Site	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:54945036T>C	ENST00000539768.1	-	9	1058	c.1060_splice	c.e9+1	p.P353_splice	SLC38A9_ENST00000515629.1_Splice_Site_p.P290_splice|SLC38A9_ENST00000416547.2_Splice_Site_p.P229_splice|SLC38A9_ENST00000318672.3_Splice_Site_p.P353_splice|SLC38A9_ENST00000512595.1_Intron|SLC38A9_ENST00000396865.2_Splice_Site_p.P353_splice			Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	353					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				AAAGCTCACCTGGTACAAAAA	0.303000													6	12					0	0	0.001168	0	0
MYT1L	23040	broad.mit.edu	37	2	1914014	1914014	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1914014G>A	ENST00000399161.2	-	13	2562	c.1815C>T	c.(1813-1815)ctC>ctT	p.L605L	MYT1L_ENST00000428368.2_Silent_p.L603L	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	605					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTGGGTACCTGAGCACGCGGT	0.637000													5	37					0	0	0.000602	0	0
ORM2	5005	broad.mit.edu	37	9	117092788	117092788	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:117092788A>T	ENST00000431067.2	+	2	225	c.189A>T	c.(187-189)caA>caT	p.Q63H	ORM2_ENST00000412657.1_3'UTR	NM_000608.2	NP_000599.1			orosomucoid 2											breast(1)|endometrium(1)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(1)	7		Myeloproliferative disorder(63;0.163)				AGGAGATCCAAGCAACCTTCT	0.512000													28	48					0	0	0.002445	0	0
GFRA2	2675	broad.mit.edu	37	8	21560483	21560483	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:21560483G>C	ENST00000524240.1	-	7	1702	c.1052C>G	c.(1051-1053)gCc>gGc	p.A351G	GFRA2_ENST00000518077.1_Missense_Mutation_p.A218G|GFRA2_ENST00000517328.1_Missense_Mutation_p.A351G|GFRA2_ENST00000400782.4_Missense_Mutation_p.A246G	NM_001495.4	NP_001486.4	O00451	GFRA2_HUMAN	GDNF family receptor alpha 2	351						anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|prostate(1)|skin(1)	7				Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		GGCCTGGATGGCGTTCCCTGG	0.632000													5	11					0	0	0.001168	0	0
ABCA12	26154	broad.mit.edu	37	2	215976318	215976318	+	Splice_Site	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:215976318A>T	ENST00000272895.7	-	2	383		c.e2+1		ABCA12_ENST00000412081.1_Splice_Site	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12						cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCATTTACTTACAAGTTGGTT	0.294000													19	22					0	0	0.001523	0	0
C20orf85	128602	broad.mit.edu	37	20	56735866	56735866	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:56735866G>T	ENST00000371168.3	+	4	463	c.402G>T	c.(400-402)caG>caT	p.Q134H		NM_178456.2	NP_848551.1	Q9H1P6	CT085_HUMAN	chromosome 20 open reading frame 85	134										kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	13	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			GGCCCAAGCAGGGCGTGCACT	0.597000													11	14					3.07112e-06	5.37379e-06	0.000978	1	0
GTF2IRD1	9569	broad.mit.edu	37	7	73969543	73969543	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:73969543G>T	ENST00000476977.1	+	18	3647	c.1956G>T	c.(1954-1956)atG>atT	p.M652I	GTF2IRD1_ENST00000455841.2_Missense_Mutation_p.M684I|GTF2IRD1_ENST00000489094.1_3'UTR|GTF2IRD1_ENST00000265755.3_Missense_Mutation_p.M652I|GTF2IRD1_ENST00000424337.2_Missense_Mutation_p.M652I			Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1	652			M -> V (in dbSNP:rs2301895).			nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(19)|ovary(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AGCCCATCATGGATAGTCAAG	0.637000													23	57					2.89027e-11	5.74333e-11	0.002299	1	0
ATP6V1C1	528	broad.mit.edu	37	8	104068161	104068161	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:104068161G>A	ENST00000395862.3	+	8	797	c.638G>A	c.(637-639)aGc>aAc	p.S213N	ATP6V1C1_ENST00000518738.1_Missense_Mutation_p.S213N|ATP6V1C1_ENST00000518857.1_Missense_Mutation_p.S138N|ATP6V1C1_ENST00000521514.1_Missense_Mutation_p.S138N	NM_001695.4	NP_001686.1	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1	213					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			CCAAGGTCTAGCAAGTAAGTA	0.373000													9	30					0	0	0.004482	0	0
OR6K6	128371	broad.mit.edu	37	1	158724824	158724824	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:158724824G>T	ENST00000368144.2	+	1	315	c.219G>T	c.(217-219)atG>atT	p.M73I		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					ACCTAATAATGTTCATTGTCA	0.468000													32	125					1.45844e-13	3.03954e-13	0.002836	1	0
OR52I1	390037	broad.mit.edu	37	11	4615655	4615655	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:4615655C>T	ENST00000450052.2	+	2	459	c.459C>T	c.(457-459)gcC>gcT	p.A153A	OR52I1_ENST00000530443.2_Silent_p.A129A			Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I, member 1	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	15		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTATGTAGCCATCTGCAAGC	0.498000													17	34					0	0	0.001216	0	0
ARSI	340075	broad.mit.edu	37	5	149678016	149678016	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:149678016A>G	ENST00000328668.7	-	2	1050	c.471T>C	c.(469-471)tgT>tgC	p.C157C		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	157						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGTGGGCAGACACTCCTTCC	0.607000													19	38					0	0	0.001523	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073049	17073049	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:17073049T>A	ENST00000359963.3	-	1	651	c.392A>T	c.(391-393)cAg>cTg	p.Q131L		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	131					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CTCCCGGAGCTGCGGGCGAGG	0.652000													15	41					0	0	0.002450	0	0
KRT33B	3884	broad.mit.edu	37	17	39521745	39521745	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:39521745G>T	ENST00000251646.3	-	4	698	c.649C>A	c.(649-651)Ccc>Acc	p.P217T		NM_002279.4	NP_002270.1	Q14525	KT33B_HUMAN	keratin 33B	217	Linker 12.|Rod.					intermediate filament	protein binding|structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(6)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000496)				TCCACAGCGGGAGCAGCGTCC	0.557000													17	49					4.14922e-12	8.34417e-12	0.004007	1	0
MUC16	94025	broad.mit.edu	37	19	9015728	9015728	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9015728C>A	ENST00000397910.4	-	29	38298	c.38095G>T	c.(38095-38097)Gtg>Ttg	p.V12699L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12701	SEA 5.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGAACGGCACCAGGAGAGGG	0.458000													35	113					0.000109025	0.000182193	0.003755	1	0
HAO1	54363	broad.mit.edu	37	20	7915261	7915261	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:7915261C>G	ENST00000378789.3	-	2	210	c.159G>C	c.(157-159)atG>atC	p.M53I		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	53	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CATTCCGGAGCATCCTTGGAT	0.403000													24	54					0	0	0.002299	0	0
SNX19	399979	broad.mit.edu	37	11	130773227	130773227	+	Silent	SNP	T	T	C	rs138603150		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:130773227T>C	ENST00000265909.4	-	8	3065	c.2496A>G	c.(2494-2496)ctA>ctG	p.L832L	SNX19_ENST00000528555.1_Silent_p.L212L|SNX19_ENST00000539184.1_Silent_p.L275L|SNX19_ENST00000530356.1_Silent_p.L212L|SNX19_ENST00000545537.1_Silent_p.L72L|SNX19_ENST00000534726.1_Silent_p.L72L|SNX19_ENST00000533318.1_5'UTR	NM_014758.2	NP_055573.2	Q92543	SNX19_HUMAN	sorting nexin 19	832					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(8)|ovary(3)|prostate(1)|skin(6)|urinary_tract(1)	35	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		ACTGTTCTGTTAGTAGCAAGA	0.448000													12	34					0	0	0.000978	0	0
RAD50	10111	broad.mit.edu	37	5	131953939	131953939	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:131953939A>T	ENST00000378823.3	+	21	3743	c.2925A>T	c.(2923-2925)acA>acT	p.T975T	RAD50_ENST00000265335.6_Silent_p.T1114T	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	1114					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGAGGACAACAGAACTTGTGA	0.318000								Homologous recombination					26	57					0	0	0.003330	0	0
IGHD	3495	broad.mit.edu	37	14	106307453	106307453	+	RNA	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:106307453C>T	ENST00000390556.2	-	0	584																											TCCTTCAGGTCACTGCCCACC	0.657000													6	11					0	0	0.001168	0	0
ASZ1	136991	broad.mit.edu	37	7	117023080	117023080	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:117023080A>T	ENST00000284629.2	-	7	834	c.772T>A	c.(772-774)Ttg>Atg	p.L258M		NM_130768.2	NP_570124.1	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper domain containing 1	258					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(3)|skin(1)	24	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TCTGTTGTCAATATTTTACAA	0.259000													12	46					0	0	0.000978	0	0
ACAP2	23527	broad.mit.edu	37	3	195012437	195012437	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:195012437T>A	ENST00000326793.6	-	20	2291	c.2061A>T	c.(2059-2061)acA>acT	p.T687T		NM_012287.5	NP_036419.3	Q15057	ACAP2_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	687					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	27						GCAGTTACCCTGTGTGCCCTA	0.403000													19	114					0	0	0.000958	0	0
TAS2R40	259286	broad.mit.edu	37	7	142919319	142919319	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:142919319G>C	ENST00000408947.3	+	1	190	c.148G>C	c.(148-150)Ggc>Cgc	p.G50R	AC073342.1_ENST00000595842.1_Silent_p.A14A	NM_176882.1	NP_795363.1	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	50					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8	Melanoma(164;0.059)					GTGGGCCAGGGGCAAAACACT	0.522000													23	66					0	0	0.003330	0	0
CST8	10047	broad.mit.edu	37	20	23476506	23476506	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23476506G>C	ENST00000246012.1	+	4	741	c.384G>C	c.(382-384)tgG>tgC	p.W128C		NM_005492.2	NP_005483.1	O60676	CST8_HUMAN	cystatin 8 (cystatin-related epididymal specific)	128						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(9)|skin(2)	16	Colorectal(13;0.0431)|Lung NSC(19;0.235)					CACTTCCCTGGAATGGTGAAT	0.358000													26	48					0	0	0.001271	0	0
ENPP1	5167	broad.mit.edu	37	6	132172336	132172336	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:132172336G>T	ENST00000360971.2	+	4	505	c.485G>T	c.(484-486)aGc>aTc	p.S162I		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	162	SMB 2.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TTGACCAGAAGCCTCTGTGCC	0.458000													32	61					2.42023e-17	5.45776e-17	0.003271	1	0
CD38	952	broad.mit.edu	37	4	15780186	15780186	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:15780186G>T	ENST00000226279.2	+	1	286	c.149G>T	c.(148-150)tGg>tTg	p.W50L		NM_001775.2	NP_001766.2	P28907	CD38_HUMAN	CD38 molecule	50					B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|stomach(1)	14						CGCCAGCAGTGGAGCGGTCCG	0.617000													36	84					2.87052e-16	6.37999e-16	0.005524	1	0
POU2F3	25833	broad.mit.edu	37	11	120180221	120180221	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:120180221C>A	ENST00000260264.4	+	10	1034	c.1000C>A	c.(1000-1002)Cga>Aga	p.R334R	POU2F3_ENST00000543440.2_Silent_p.R332R	NM_001244682.1	NP_001231611.1	Q9UKI9	PO2F3_HUMAN	POU class 2 homeobox 3	332					negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding	p.R332*(1)		large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)	17		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		GTTCTGCAACCGACGCCAAAA	0.557000													19	41					1.33834e-09	2.57284e-09	0.000958	1	0
LILRA4	23547	broad.mit.edu	37	19	54848235	54848235	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54848235C>A	ENST00000291759.4	-	6	1188	c.1132G>T	c.(1132-1134)Gct>Tct	p.A378S	AC008984.2_ENST00000507363.1_RNA	NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	378	Ig-like C2-type 4.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GGGAATTCAGCCTGGTACTTA	0.587000													51	158					1.21353e-23	2.98111e-23	0.003610	1	0
COL11A2	1302	broad.mit.edu	37	6	33146101	33146101	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:33146101C>A	ENST00000341947.2	-	20	2029	c.1802G>T	c.(1801-1803)gGg>gTg	p.G601V	COL11A2_ENST00000395197.1_Missense_Mutation_p.G541V|COL11A2_ENST00000357486.1_Missense_Mutation_p.G580V|COL11A2_ENST00000374708.4_Missense_Mutation_p.G515V|COL11A2_ENST00000361917.1_Missense_Mutation_p.G494V|COL11A2_ENST00000374712.1_Missense_Mutation_p.G520V|COL11A2_ENST00000374713.1_Missense_Mutation_p.G554V|COL11A2_ENST00000374714.1_Missense_Mutation_p.G575V	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	601	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TCCAGGCAGCCCTCGAGGCCC	0.617000													18	141					4.75885e-15	1.03143e-14	0.004990	1	0
MYT1	4661	broad.mit.edu	37	20	62830234	62830234	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:62830234A>T	ENST00000536311.1	+	3	384	c.20A>T	c.(19-21)gAc>gTc	p.D7V	MYT1_ENST00000360149.4_Missense_Mutation_p.D7V|MYT1_ENST00000328439.1_Missense_Mutation_p.D7V			Q01538	MYT1_HUMAN	myelin transcription factor 1	7					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GAAAATGAAGACAAGCGAGCT	0.557000													11	29					0	0	0.000673	0	0
TRAV29DV5	28653	broad.mit.edu	37	14	22631741	22631741	+	RNA	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:22631741T>A	ENST00000390458.3	+	0	444																											CTGGAGACTCTGCAGTGTACT	0.507000													12	27					0	0	0.000978	0	0
IDH1	3417	broad.mit.edu	37	2	209116227	209116227	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:209116227C>T	ENST00000415913.1	-	3	430	c.49G>A	c.(49-51)Gaa>Aaa	p.E17K	IDH1_ENST00000345146.2_Missense_Mutation_p.E17K|IDH1_ENST00000446179.1_Missense_Mutation_p.E17K			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	17					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		CGTGTCATTTCATCTCCTTGC	0.358000			Mis		gliobastoma								27	31					0	0	0.001061	0	0
LPPR3	79948	broad.mit.edu	37	19	814685	814685	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:814685G>T	ENST00000359894.2	-	6	727	c.664C>A	c.(664-666)Ccg>Acg	p.P222T	LPPR3_ENST00000520876.3_Intron	NM_024888.2	NP_079164.1	Q6T4P5	LPPR3_HUMAN		219						integral to membrane	phosphatidate phosphatase activity										TGAGGGGCCGGACTCACCGAC	0.662000													23	24					2.52088e-20	5.96627e-20	0.002780	1	0
DSCAML1	57453	broad.mit.edu	37	11	117332289	117332289	+	Missense_Mutation	SNP	C	C	A	rs142275732		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:117332289C>A	ENST00000321322.6	-	18	3470	c.3469G>T	c.(3469-3471)Gtc>Ttc	p.V1157F	DSCAML1_ENST00000527706.1_Missense_Mutation_p.V887F	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1097	Fibronectin type-III 3.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGGGCCCGGACGTTCTCAGGG	0.612000													17	47					2.4624e-09	4.69775e-09	0.001216	1	0
OR5H14	403273	broad.mit.edu	37	3	97868383	97868383	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:97868383G>A	ENST00000437310.1	+	1	214	c.154G>A	c.(154-156)Gac>Aac	p.D52N		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CATCTGGAAAGACCCTCATCT	0.413000													89	425					0	0	0.003610	0	0
IGHV6-1	28385	broad.mit.edu	37	14	106405743	106405743	+	RNA	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:106405743G>A	ENST00000390593.2	-	0	282																											TATACCACTTGGACCTGTAGT	0.502000													42	86					0	0	0.002222	0	0
LBP	3929	broad.mit.edu	37	20	36993246	36993246	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:36993246G>A	ENST00000217407.2	+	8	922	c.761G>A	c.(760-762)cGt>cAt	p.R254H		NM_004139.3	NP_004130.2	P18428	LBP_HUMAN	lipopolysaccharide binding protein	254					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(1)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				ATCTTTCATCGTAACCACCGT	0.488000													38	61					0	0	0.004289	0	0
MEIS1	4211	broad.mit.edu	37	2	66664968	66664968	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:66664968C>T	ENST00000488550.1	+	2	411	c.112C>T	c.(112-114)Cac>Tac	p.H38Y	MEIS1_ENST00000407092.2_Missense_Mutation_p.H38Y|MEIS1_ENST00000444274.2_Missense_Mutation_p.H6Y|MEIS1_ENST00000272369.9_Missense_Mutation_p.H38Y|MEIS1_ENST00000398506.2_Missense_Mutation_p.H36Y|MEIS1_ENST00000560281.2_Missense_Mutation_p.H38Y			O00470	MEIS1_HUMAN	Meis homeobox 1	38							sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	24						GCCGGTCCACCACCTGAACCA	0.612000													7	25					0	0	0.004482	0	0
CCK	885	broad.mit.edu	37	3	42304950	42304950	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:42304950A>T	ENST00000396169.2	-	4	1078	c.173T>A	c.(172-174)cTg>cAg	p.L58Q	CCK_ENST00000434608.1_Missense_Mutation_p.L58Q|CCK_ENST00000334681.5_Missense_Mutation_p.L58Q	NM_000729.4	NP_000720.1	P06307	CCKN_HUMAN	cholecystokinin	58					axonogenesis|eating behavior|neuron migration		neuropeptide hormone activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6		Ovarian(412;0.0728)		KIRC - Kidney renal clear cell carcinoma(284;0.219)		CAGGGCGCCCAGGTGCGCTCG	0.672000													32	58					0	0	0.003755	0	0
MYT1L	23040	broad.mit.edu	37	2	1890319	1890319	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1890319T>A	ENST00000399161.2	-	18	3450	c.2703A>T	c.(2701-2703)caA>caT	p.Q901H	MYT1L_ENST00000428368.2_Missense_Mutation_p.Q899H	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	901					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		ACTTGAGTTCTTGGGAGCTGG	0.433000													18	42					0	0	0.006122	0	0
PCDH17	27253	broad.mit.edu	37	13	58208540	58208540	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:58208540C>A	ENST00000377918.3	+	1	1886	c.1860C>A	c.(1858-1860)agC>agA	p.S620R		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	620	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TCGGCGAGAGCGGGCGTCTCA	0.662000													28	34					1.77063e-15	3.87531e-15	0.005443	1	0
WNT8A	7478	broad.mit.edu	37	5	137419813	137419813	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:137419813G>C	ENST00000398754.1	+	1	40	c.35G>C	c.(34-36)gGc>gCc	p.G12A	WNT8A_ENST00000506684.1_5'UTR	NM_058244.2	NP_490645.1	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family, member 8A	12					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(2)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCAGCTCTGGGCATATGCTGT	0.587000													13	38					0	0	0.002450	0	0
FBXO10	26267	broad.mit.edu	37	9	37531943	37531943	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:37531943C>G	ENST00000432825.2	-	4	1580	c.1532G>C	c.(1531-1533)gGt>gCt	p.G511A	RP11-613M10.8_ENST00000544475.1_5'UTR|FBXO10_ENST00000543968.1_5'UTR|FBXO10_ENST00000541829.1_Missense_Mutation_p.G36A	NM_012166.2	NP_036298.2	Q9UK96	FBX10_HUMAN	F-box protein 10	511						ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(1)|endometrium(5)|large_intestine(11)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	34				GBM - Glioblastoma multiforme(29;0.0107)		GATGTCTACACCAGCCTCTGC	0.493000													12	42					0	0	0.001368	0	0
ZNF705B	100132396	broad.mit.edu	37	8	7806693	7806693	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:7806693G>T	ENST00000443676.1	+	3	171	c.55G>T	c.(55-57)Gaa>Taa	p.E19*	ZNF705B_ENST00000400120.3_Nonsense_Mutation_p.E19*			P0CI00	Z705L_HUMAN	zinc finger protein 705B	19	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			kidney(2)|lung(2)	4						CTTCACCCAGGAAGAGTGGGA	0.423000													44	46					2.81731e-22	6.82067e-22	0.003610	1	0
CDH11	1009	broad.mit.edu	37	16	65016141	65016141	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:65016141C>T	ENST00000394156.3	-	8	1516	c.1063G>A	c.(1063-1065)Gac>Aac	p.D355N	CDH11_ENST00000268603.4_Missense_Mutation_p.D355N|CDH11_ENST00000566827.1_Missense_Mutation_p.D229N			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	355	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AACTTCGGGTCGATGTGCACG	0.468000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			19	22					0	0	0.001216	0	0
RUSC2	9853	broad.mit.edu	37	9	35557972	35557972	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35557972G>T	ENST00000455600.1	+	6	3614	c.3045G>T	c.(3043-3045)cgG>cgT	p.R1015R		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1015						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GCACAAGCCGGGATCCCGGGG	0.557000													24	73					3.80469e-20	8.98355e-20	0.001786	1	0
PRKCG	5582	broad.mit.edu	37	19	54403889	54403889	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54403889G>A	ENST00000263431.3	+	14	1743	c.1461G>A	c.(1459-1461)atG>atA	p.M487I	PRKCG_ENST00000540413.1_Missense_Mutation_p.M487I|PRKCG_ENST00000542049.1_Missense_Mutation_p.M374I	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	487	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACAATGTGATGCTGGATGCTG	0.542000													70	129					0	0	0.003610	0	0
ELL2	22936	broad.mit.edu	37	5	95234300	95234300	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:95234300T>A	ENST00000237853.4	-	8	1518	c.1169A>T	c.(1168-1170)cAg>cTg	p.Q390L	ELL2_ENST00000431061.2_Splice_Site	NM_012081.5	NP_036213.2	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	390					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	24		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		ATTTACAATCTGAGGAGGATG	0.537000													38	79					0	0	0.004289	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21349914	21349914	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:21349914G>A	ENST00000256958.2	+	8	858	c.762G>A	c.(760-762)tgG>tgA	p.W254*		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	254					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	ATTCTCGATGGGTTGGAGCTT	0.358000													40	96					0	0	0.001706	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84606419	84606419	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:84606419G>T	ENST00000344803.2	+	4	1081	c.1034G>T	c.(1033-1035)gGc>gTc	p.G345V		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		ACAATCAAAGGCATTGACCAT	0.458000													39	84					1.07121e-22	2.61229e-22	0.001485	1	0
CAPN13	92291	broad.mit.edu	37	2	30959385	30959385	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:30959385C>G	ENST00000295055.8	-	18	1882	c.1706G>C	c.(1705-1707)cGc>cCc	p.R569P	CAPN13_ENST00000534090.2_Missense_Mutation_p.R569P	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	569	EF-hand 1.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity	p.R569H(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					GTGAACAAGGCGCTTCCACAG	0.532000													23	46					0	0	0.003330	0	0
LVRN	206338	broad.mit.edu	37	5	115336169	115336169	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:115336169G>T	ENST00000357872.4	+	8	1679	c.1555G>T	c.(1555-1557)Gag>Tag	p.E519*	AQPEP_ENST00000395528.2_Nonsense_Mutation_p.E36*	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		519					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										TTTCTTGAATGAGCATTTATT	0.378000													30	87					9.65963e-10	1.86952e-09	0.003271	1	0
C2CD5	9847	broad.mit.edu	37	12	22680700	22680700	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:22680700C>A	ENST00000333957.4	-	4	559	c.304G>T	c.(304-306)Gca>Tca	p.A102S	C2CD5_ENST00000536386.1_Missense_Mutation_p.A102S|C2CD5_ENST00000545552.1_Missense_Mutation_p.A102S|C2CD5_ENST00000542676.1_Missense_Mutation_p.A102S|C2CD5_ENST00000446597.1_Missense_Mutation_p.A102S|C2CD5_ENST00000396028.2_Missense_Mutation_p.A102S|C2CD5_ENST00000544930.1_5'UTR	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		ATGACTGTTGCAGCTTCACTA	0.323000													23	67					2.79863e-10	5.46387e-10	0.004656	1	0
NIPAL4	348938	broad.mit.edu	37	5	156899365	156899365	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:156899365G>A	ENST00000311946.7	+	6	914	c.798G>A	c.(796-798)ctG>ctA	p.L266L	NIPAL4_ENST00000435489.2_Silent_p.L247L|ADAM19_ENST00000430702.2_Intron	NM_001099287.1	NP_001092757.1	Q0D2K0	NIPA4_HUMAN	NIPA-like domain containing 4	266						integral to membrane	receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|prostate(1)|skin(1)	22						CTGTGCTTCTGCTGGTGTCAT	0.527000											OREG0016979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	73	150					0	0	0.003610	0	0
CIITA	4261	broad.mit.edu	37	16	10971201	10971201	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:10971201C>T	ENST00000324288.8	+	1	147	c.14C>T	c.(13-15)gCt>gTt	p.A5V	CIITA_ENST00000381835.5_Missense_Mutation_p.A5V|RP11-876N24.2_ENST00000573071.1_RNA|CIITA_ENST00000537380.1_3'UTR|RP11-876N24.2_ENST00000572017.1_RNA	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	5					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						CGTTGCCTGGCTCCACGCCCT	0.602000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								6	13					0	0	0.001984	0	0
REG1P	5969	broad.mit.edu	37	2	79363902	79363902	+	RNA	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:79363902T>G	ENST00000444841.1	-	0	436																											AGGTAGAAGATGCAGCAGACT	0.473000													3	15					0	0	0.004672	0	0
DNAH9	1770	broad.mit.edu	37	17	11648295	11648295	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:11648295T>A	ENST00000262442.3	+	31	6361	c.6293T>A	c.(6292-6294)tTt>tAt	p.F2098Y	DNAH9_ENST00000454412.2_Missense_Mutation_p.F2098Y	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2098					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGGGACCTCTTTCCCGCCCTG	0.562000													18	49					0	0	0.004990	0	0
PLAGL1	5325	broad.mit.edu	37	6	144263314	144263314	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:144263314T>C	ENST00000360537.2	-	5	2552	c.639A>G	c.(637-639)aaA>aaG	p.K213K	PLAGL1_ENST00000444202.1_Silent_p.K213K|PLAGL1_ENST00000429150.1_Silent_p.K213K|PLAGL1_ENST00000392309.1_Silent_p.K213K|PLAGL1_ENST00000367572.1_Silent_p.K161K|PLAGL1_ENST00000354765.2_Silent_p.K213K|PLAGL1_ENST00000392307.1_Silent_p.K161K|PLAGL1_ENST00000416623.1_Silent_p.K213K|PLAGL1_ENST00000367571.1_Silent_p.K213K|PLAGL1_ENST00000437412.1_Silent_p.K161K			Q9UM63	PLAL1_HUMAN	pleiomorphic adenoma gene-like 1	213					cell cycle arrest|induction of apoptosis|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(2)|prostate(1)|skin(3)|stomach(2)	13				OV - Ovarian serous cystadenocarcinoma(155;5.74e-07)|GBM - Glioblastoma multiforme(68;0.0885)		GCAAGCTCTCTTTCATCAGCT	0.547000											OREG0017707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	107					0	0	0.003214	0	0
ZNF25	219749	broad.mit.edu	37	10	38242024	38242024	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:38242024T>A	ENST00000302609.7	-	6	614	c.402A>T	c.(400-402)atA>atT	p.I134I	ZNF25_ENST00000374633.1_5'UTR	NM_145011.2	NP_659448.1	P17030	ZNF25_HUMAN	zinc finger protein 25	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				GCTGATGTACTATGAGGGCAG	0.398000													43	107					0	0	0.002522	0	0
CDH6	1004	broad.mit.edu	37	5	31323216	31323216	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:31323216C>A	ENST00000265071.2	+	12	2439	c.2174C>A	c.(2173-2175)aCg>aAg	p.T725K		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	725					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding	p.T725K(1)		NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GAAAATGACACGGACCCCACT	0.562000													13	35					0.00010058	0.00016822	0.001368	1	0
NAV3	89795	broad.mit.edu	37	12	78400500	78400500	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:78400500G>C	ENST00000397909.2	+	8	1355	c.1182G>C	c.(1180-1182)cgG>cgC	p.R394R	NAV3_ENST00000266692.7_Silent_p.R394R|NAV3_ENST00000536525.2_Silent_p.R394R|NAV3_ENST00000228327.6_Silent_p.R394R			Q8IVL0	NAV3_HUMAN	neuron navigator 3	394						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TCAATGCCCGGACTGCTTTAC	0.498000										HNSCC(70;0.22)			25	69					0	0	0.003954	0	0
EIF4E1B	253314	broad.mit.edu	37	5	176072481	176072481	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:176072481G>A	ENST00000318682.6	+	8	1162	c.578G>A	c.(577-579)aGg>aAg	p.R193K	EIF4E1B_ENST00000504597.1_Missense_Mutation_p.R193K|EIF4E1B_ENST00000512734.1_3'UTR	NM_001099408.1	NP_001092878.1	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E family member 1B	193					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity			breast(1)|large_intestine(1)|lung(2)|pancreas(1)	5	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTGTGGACGAGGGAGGCGGAA	0.622000													13	29					0	0	0.001855	0	0
PGGT1B	5229	broad.mit.edu	37	5	114573587	114573587	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:114573587C>G	ENST00000419445.1	-	4	467	c.447G>C	c.(445-447)gcG>gcC	p.A149A	PGGT1B_ENST00000379615.3_Silent_p.A149A	NM_005023.3	NP_005014.2	P53609	PGTB1_HUMAN	protein geranylgeranyltransferase type I, beta subunit	149					protein geranylgeranylation	CAAX-protein geranylgeranyltransferase complex	CAAX-protein geranylgeranyltransferase activity			breast(2)|endometrium(1)|large_intestine(2)|lung(1)	6		all_cancers(142;0.000523)|all_epithelial(76;6.45e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		Epithelial(69;2.95e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.98e-08)|all cancers(49;3.1e-06)	Pravastatin(DB00175)	CTCTCAAGCCCGCTAAGCAAG	0.388000													26	75					0	0	0.001061	0	0
CAPS2	84698	broad.mit.edu	37	12	75687068	75687068	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:75687068C>A	ENST00000393284.3	-	12	1086	c.485G>T	c.(484-486)cGa>cTa	p.R162L	CAPS2_ENST00000409004.1_5'UTR|RP11-560G2.1_ENST00000549953.1_RNA|CAPS2_ENST00000442339.2_5'UTR|CAPS2_ENST00000409445.3_Missense_Mutation_p.R394L|CAPS2_ENST00000409799.1_Missense_Mutation_p.R312L			Q9BXY5	CAYP2_HUMAN	calcyphosine 2	394							calcium ion binding			endometrium(2)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	10						ATTTGTGATTCGGAGTTTAAG	0.318000													19	52					5.3912e-06	9.37621e-06	0.006122	1	0
CNTRL	11064	broad.mit.edu	37	9	123875817	123875817	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:123875817A>G	ENST00000373855.1	+	10	1420	c.1160A>G	c.(1159-1161)tAc>tGc	p.Y387C	CNTRL_ENST00000238341.5_Missense_Mutation_p.Y387C|CNTRL_ENST00000373865.2_Missense_Mutation_p.Y387C			Q7Z7A1	CNTRL_HUMAN	centriolin	387					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GAAAGCCCTTACATTGGCAAA	0.358000													26	64					0	0	0.004656	0	0
BTNL3	10917	broad.mit.edu	37	5	180424227	180424227	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:180424227C>G	ENST00000342868.6	+	3	596	c.412C>G	c.(412-414)Cct>Gct	p.P138A		NM_197975.2	NP_932079.1	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3	138	Ig-like V-type.				lipid metabolic process	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(10)|prostate(2)|skin(1)	25	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			GGGCTCACTTCCTCTCATTTC	0.498000													39	128					0	0	0.002852	0	0
C7orf10	79783	broad.mit.edu	37	7	40234623	40234623	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:40234623G>C	ENST00000309930.5	+	6	493	c.469G>C	c.(469-471)Gag>Cag	p.E157Q	C7orf10_ENST00000401647.2_Missense_Mutation_p.E157Q|C7orf10_ENST00000335693.4_Missense_Mutation_p.E157Q|C7orf10_ENST00000540834.1_Missense_Mutation_p.E150Q	NM_001193311.1|NM_024728.2	NP_001180240.1|NP_079004.1	Q9HAC7	CG010_HUMAN	chromosome 7 open reading frame 10	157							transferase activity	p.E157*(2)		endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)	18						AGATATAGACGAGATTGCTCC	0.428000													44	138					0	0	0.003610	0	0
PTPRN2	5799	broad.mit.edu	37	7	158334258	158334258	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:158334258G>A	ENST00000404321.2	-	1	40	c.41C>T	c.(40-42)gCc>gTc	p.A14V	PTPRN2_ENST00000409483.1_Intron|PTPRN2_ENST00000389416.4_Intron|PTPRN2_ENST00000389413.3_Intron|PTPRN2_ENST00000389418.4_Intron			Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	0						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AGGAAAGCTGGCTTCGGTTCT	0.483000													33	67					0	0	0.002836	0	0
IGKV1-5	28299	broad.mit.edu	37	2	89246986	89246986	+	RNA	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:89246986G>T	ENST00000496168.1	-	0	364																											GCTTTCCCTGGTTTCTGCTGA	0.522000													41	101					5.71845e-15	1.23541e-14	0.005524	1	0
TP53	7157	broad.mit.edu	37	17	7577138	7577138	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:7577138C>G	ENST00000420246.2	-	8	932	c.800G>C	c.(799-801)cGg>cCg	p.R267P	TP53_ENST00000455263.2_Missense_Mutation_p.R267P|TP53_ENST00000269305.4_Missense_Mutation_p.R267P|TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Missense_Mutation_p.R267P|TP53_ENST00000359597.4_Missense_Mutation_p.R267P	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	267	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation; dbSNP:rs55832599).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R267P(17)|p.R267Q(10)|p.0?(8)|p.R267L(6)|p.N268fs*77(3)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.L265_R267delLGR(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AAAGCTGTTCCGTCCCAGTAG	0.527000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	17					0	0	0.001882	0	0
PRR5	55615	broad.mit.edu	37	22	45132772	45132772	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:45132772C>A	ENST00000403581.1	+	10	1490	c.881C>A	c.(880-882)gCg>gAg	p.A294E	PRR5_ENST00000336985.6_Missense_Mutation_p.A271E|PRR5_ENST00000477331.1_3'UTR|PRR5-ARHGAP8_ENST00000361473.5_Intron|ARHGAP8_ENST00000389773.5_Intron|PRR5-ARHGAP8_ENST00000352766.7_Intron|ARHGAP8_ENST00000517296.3_Intron	NM_001198721.1	NP_001185650.1			proline rich 5 (renal)											central_nervous_system(1)|endometrium(2)|lung(6)|prostate(1)|skin(1)	11		all_neural(38;0.00409)|Ovarian(80;0.024)|Glioma(61;0.0647)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)		GCGGAGGGCGCGGCGGCCGGC	0.711000													13	39					1.5842e-08	2.96042e-08	0.001855	1	0
TNN	63923	broad.mit.edu	37	1	175054604	175054604	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:175054604A>G	ENST00000239462.4	+	6	1411	c.1298A>G	c.(1297-1299)aAg>aGg	p.K433R		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	433	Fibronectin type-III 2.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CTGGAGGGCAAGCCGATCCTC	0.532000													6	16					0	0	0.001984	0	0
POLE	5426	broad.mit.edu	37	12	133257867	133257867	+	Splice_Site	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133257867T>A	ENST00000320574.5	-	2	106		c.e2-2		POLE_ENST00000535270.1_Splice_Site	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit						base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CCATCATCCCTGAGTGAAAGA	0.473000								DNA polymerases (catalytic subunits)					35	82					0	0	0.003271	0	0
ARAP3	64411	broad.mit.edu	37	5	141059771	141059771	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:141059771C>A	ENST00000239440.4	-	2	348	c.283G>T	c.(283-285)Gtg>Ttg	p.V95L	ARAP3_ENST00000508305.1_Missense_Mutation_p.V17L	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	95	Pro-rich.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						GGCTTCGGCACGGGCTTAGGG	0.657000													22	73					7.41877e-09	1.39415e-08	0.001882	1	0
AKAP12	9590	broad.mit.edu	37	6	151670376	151670376	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:151670376C>A	ENST00000402676.2	+	4	1090	c.850C>A	c.(850-852)Ccg>Acg	p.P284T	AKAP12_ENST00000253332.1_Missense_Mutation_p.P284T|AKAP12_ENST00000359755.5_Missense_Mutation_p.P179T|AKAP12_ENST00000354675.6_Missense_Mutation_p.P186T	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	284	Involved in PKC-binding (Probable).				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		TGCAGAATCTCCGACTAGTCC	0.483000													16	33					2.31682e-05	3.9439e-05	0.003163	1	0
OR2AK2	391191	broad.mit.edu	37	1	248129117	248129117	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248129117T>A	ENST00000366480.3	+	1	583	c.484T>A	c.(484-486)Tgt>Agt	p.C162S	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CATGGTTGCATGTGCATGGGC	0.413000													111	148					0	0	0.003610	0	0
SLC18B1	116843	broad.mit.edu	37	6	133110904	133110904	+	Splice_Site	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:133110904C>G	ENST00000275227.4	-	4	448	c.353_splice	c.e4+1	p.G118_splice	SLC18B1_ENST00000460518.1_5'UTR|SLC18B1_ENST00000367918.1_Intron|SLC18B1_ENST00000538764.1_Splice_Site_p.W41_splice	NM_052831.2	NP_439896.1	Q6NT16	CF192_HUMAN	solute carrier family 18, subfamily B, member 1	118					transmembrane transport	integral to membrane											ATGACTTACCCAAAGAGAATT	0.308000													26	72					0	0	0.001061	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84608809	84608809	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:84608809G>T	ENST00000344803.2	+	4	3471	c.3424G>T	c.(3424-3426)Ggc>Tgc	p.G1142C		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		CAGGCTTCAGGGCAGTAGAAA	0.468000													21	30					1.00905e-13	2.10954e-13	0.001216	1	0
FAM174A	345757	broad.mit.edu	37	5	99871504	99871504	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:99871504G>T	ENST00000312637.4	+	1	496	c.270G>T	c.(268-270)ggG>ggT	p.G90G		NM_198507.1	NP_940909.1	Q8TBP5	F174A_HUMAN	family with sequence similarity 174, member A	90						integral to membrane				breast(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						CTGTGGCCGGGCTTGAGACGG	0.726000													7	13					8.12818e-05	0.000136171	0.001984	1	0
INPP4A	3631	broad.mit.edu	37	2	99179952	99179952	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:99179952C>T	ENST00000074304.5	+	19	2288	c.1895C>T	c.(1894-1896)cCg>cTg	p.P632L	INPP4A_ENST00000545415.1_Missense_Mutation_p.P593L|INPP4A_ENST00000523221.1_Missense_Mutation_p.P632L|INPP4A_ENST00000409851.3_Missense_Mutation_p.P627L|INPP4A_ENST00000409540.3_Missense_Mutation_p.P593L|INPP4A_ENST00000409463.1_Intron|INPP4A_ENST00000409016.3_Missense_Mutation_p.P593L	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	632					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						GCCCTTTACCCGCTGCTGACC	0.532000													9	29					0	0	0.004482	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99124011	99124011	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:99124011A>C	ENST00000394170.2	+	6	1599	c.1348A>C	c.(1348-1350)Aaa>Caa	p.K450Q	ZKSCAN5_ENST00000326775.5_Missense_Mutation_p.K450Q|ZKSCAN5_ENST00000451158.1_Missense_Mutation_p.K450Q	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	450					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CGAACACCTAAAACGCCACTT	0.502000													79	190					0	0	0.003610	0	0
GSS	2937	broad.mit.edu	37	20	33519801	33519801	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:33519801G>T	ENST00000216951.2	-	10	1068	c.970C>A	c.(970-972)Cag>Aag	p.Q324K	GSS_ENST00000451957.2_Missense_Mutation_p.Q213K|GSS_ENST00000541098.1_Missense_Mutation_p.Q196K	NM_000178.2	NP_000169.1	P48637	GSHB_HUMAN	glutathione synthetase	324					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	GCCTCAGGCTGGCCAGGGAGC	0.632000													51	72					1.35964e-18	3.14377e-18	0.003610	1	0
UTP18	51096	broad.mit.edu	37	17	49353297	49353297	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:49353297C>A	ENST00000225298.7	+	6	839	c.782C>A	c.(781-783)cCc>cAc	p.P261H		NM_016001.2	NP_057085.2	Q9Y5J1	UTP18_HUMAN	UTP18 small subunit (SSU) processome component homolog (yeast)	261					rRNA processing	nucleolus				breast(2)|endometrium(3)|kidney(2)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			CAGTTCCATCCCGGTGCACAG	0.383000													14	21					2.32078e-09	4.44448e-09	0.003163	1	0
CACNA1A	773	broad.mit.edu	37	19	13340911	13340911	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:13340911T>C	ENST00000360228.5	-	36	5512	c.5513A>G	c.(5512-5514)tAt>tGt	p.Y1838C	CACNA1A_ENST00000574822.1_5'UTR|CACNA1A_ENST00000573710.2_Missense_Mutation_p.Y1839C	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1839					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGCGGGGTCATACTCGGCCCA	0.587000													9	13					0	0	0.000443	0	0
TSPY2	64591	broad.mit.edu	37	Y	6114391	6114391	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:6114391G>T	ENST00000320701.4	+	1	128	c.82G>T	c.(82-84)Gcc>Tcc	p.A28S	TSPY2_ENST00000383042.1_Missense_Mutation_p.A28S	NM_022573.2	NP_072095.2	A6NKD2	TSPY2_HUMAN	testis specific protein, Y-linked 2	28					cell differentiation|gonadal mesoderm development|nucleosome assembly|spermatogenesis	cytoplasm|nucleus				liver(1)|lung(4)|prostate(1)|skin(1)	7						GGCAGCACAGGCCTTGGTGTG	0.711000													15	9					2.48551e-13	5.13211e-13	0.004990	1	0
EFTUD2	9343	broad.mit.edu	37	17	42931930	42931930	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:42931930G>A	ENST00000426333.2	-	22	2550	c.2253C>T	c.(2251-2253)ccC>ccT	p.P751P	EFTUD2_ENST00000592576.1_Silent_p.P741P|EFTUD2_ENST00000591382.1_Silent_p.P751P|EFTUD2_ENST00000402521.3_Silent_p.P716P	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	751						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				GTACCTCAGAGGGCAGAGTAT	0.522000													26	101					0	0	0.001271	0	0
CKAP5	9793	broad.mit.edu	37	11	46822845	46822845	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:46822845T>C	ENST00000529230.1	-	9	1034	c.988A>G	c.(988-990)Aag>Gag	p.K330E	CKAP5_ENST00000312055.5_Missense_Mutation_p.K330E|CKAP5_ENST00000354558.3_Missense_Mutation_p.K330E|CKAP5_ENST00000532321.1_5'UTR|CKAP5_ENST00000415402.1_Missense_Mutation_p.K330E			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	330					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						TTGGTGTCCTTTCCAACAACC	0.428000													16	33					0	0	0.004990	0	0
ATRNL1	26033	broad.mit.edu	37	10	117075142	117075142	+	Missense_Mutation	SNP	G	G	A	rs140980345		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:117075142G>A	ENST00000355044.3	+	18	3059	c.2933G>A	c.(2932-2934)cGg>cAg	p.R978Q	ATRNL1_ENST00000303745.7_5'UTR|ATRNL1_ENST00000423111.2_Missense_Mutation_p.R75Q	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	978	PSI 5.					integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GGTTCTTCACGGGGACCAATG	0.458000													27	67					0	0	0.001061	0	0
MROH9	80133	broad.mit.edu	37	1	170961417	170961417	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:170961417G>A	ENST00000367759.4	+	12	1295	c.1141G>A	c.(1141-1143)Gta>Ata	p.V381I	MROH9_ENST00000367758.3_Missense_Mutation_p.V381I	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9									p.V381I(1)									GGAGGACACCGTAACGGAAGG	0.473000													17	75					0	0	0.004990	0	0
SFRP4	6424	broad.mit.edu	37	7	37951857	37951857	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:37951857C>A	ENST00000436072.2	-	4	1032	c.655G>T	c.(655-657)Gat>Tat	p.D219Y	EPDR1_ENST00000476620.1_Intron	NM_003014.3	NP_003005.2	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related protein 4	219	NTR.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						TCTTTTACATCCACCACCGTT	0.433000													18	47					2.48551e-13	5.13211e-13	0.004990	1	0
KDM5D	8284	broad.mit.edu	37	Y	21869833	21869833	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:21869833T>A	ENST00000541639.1	-	24	3766	c.3479A>T	c.(3478-3480)gAc>gTc	p.D1160V	KDM5D_ENST00000382806.2_Missense_Mutation_p.D1072V|KDM5D_ENST00000317961.4_Missense_Mutation_p.D1129V	NM_001146705.1	NP_001140177.1	Q9BY66	KDM5D_HUMAN	lysine (K)-specific demethylase 5D	1129					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(1)|large_intestine(9)|lung(6)|skin(1)	17					Vitamin C(DB00126)	AGAGCCTGGGTCTCTGAGGTC	0.577000													12	11					0	0	0.001855	0	0
TRIM51	84767	broad.mit.edu	37	11	55653181	55653181	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55653181T>C	ENST00000449290.2	+	2	369	c.277T>C	c.(277-279)Tgt>Cgt	p.C93R		NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	93						intracellular	zinc ion binding										GGAGCAAATATGTGGGATGCA	0.488000													5	44					0	0	0.001168	0	0
FANCM	57697	broad.mit.edu	37	14	45669148	45669148	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:45669148T>C	ENST00000267430.5	+	23	6169	c.6084T>C	c.(6082-6084)taT>taC	p.Y2028Y	FANCM_ENST00000542564.2_Silent_p.Y2002Y	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	2028	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						ATATTCACTATGTATTTGACA	0.338000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				23	56					0	0	0.002299	0	0
KMT2A	4297	broad.mit.edu	37	11	118347536	118347536	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:118347536C>A	ENST00000534358.1	+	4	3196	c.3173C>A	c.(3172-3174)tCa>tAa	p.S1058*	KMT2A_ENST00000389506.5_Nonsense_Mutation_p.S1058*|KMT2A_ENST00000354520.4_Nonsense_Mutation_p.S1058*	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A									p.S1058*(1)									GAAAGTGACTCATCAGAGACC	0.438000													21	62					4.63292e-17	1.03891e-16	0.001216	1	0
ZNF10	7556	broad.mit.edu	37	12	133732562	133732562	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133732562G>A	ENST00000248211.6	+	5	952	c.730G>A	c.(730-732)Gac>Aac	p.D244N	ZNF10_ENST00000426665.2_Missense_Mutation_p.D244N|ZNF268_ENST00000416488.1_Intron|ZNF10_ENST00000402932.2_Intron|CTD-2140B24.4_ENST00000540096.2_Intron	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	244				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CCCTGATAATGACAACTCTCT	0.378000													12	27					0	0	0.001368	0	0
SNAP91	9892	broad.mit.edu	37	6	84350842	84350842	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:84350842T>C	ENST00000428679.2	-	8	1331	c.738A>G	c.(736-738)cgA>cgG	p.R246R	SNAP91_ENST00000439399.2_Silent_p.R246R|SNAP91_ENST00000521485.1_Silent_p.R246R|SNAP91_ENST00000521743.1_Silent_p.R246R|SNAP91_ENST00000369694.2_Silent_p.R246R|SNAP91_ENST00000520302.1_Silent_p.R246R|SNAP91_ENST00000195649.6_Silent_p.R246R|SNAP91_ENST00000437520.1_Silent_p.R246R|SNAP91_ENST00000520213.1_Silent_p.R246R			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	246					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		ATTCAGACACTCGTGTCATTC	0.279000													5	4					0	0	0.001168	0	0
DPYD	1806	broad.mit.edu	37	1	97700482	97700482	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:97700482T>A	ENST00000370192.3	-	19	2468	c.2368A>T	c.(2368-2370)Att>Ttt	p.I790F	DPYD-AS1_ENST00000422980.1_RNA	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	790					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GTAGCCAAAATGGGAAATCCA	0.463000													39	27					0	0	0.004878	0	0
NCAPH	23397	broad.mit.edu	37	2	97008569	97008569	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:97008569G>C	ENST00000455200.1	+	4	701	c.406G>C	c.(406-408)Gaa>Caa	p.E136Q	NCAPH_ENST00000427946.1_Missense_Mutation_p.E11Q|NCAPH_ENST00000240423.4_Missense_Mutation_p.E147Q			Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	147					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(717;0.0221)				GAAAGACACCGAACCAACCAA	0.353000													14	37					0	0	0.003163	0	0
LILRB1	10859	broad.mit.edu	37	19	55146717	55146717	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:55146717C>A	ENST00000396331.1	+	13	1924	c.1567C>A	c.(1567-1569)Cca>Aca	p.P523T	LILRB1_ENST00000396315.1_Missense_Mutation_p.P524T|LILRB1_ENST00000396327.3_Missense_Mutation_p.P524T|LILRB1_ENST00000396332.4_Missense_Mutation_p.P523T|LILRB1_ENST00000396317.1_Missense_Mutation_p.P507T|LILRB1_ENST00000448689.1_Silent_p.A497A|LILRB1_ENST00000324602.7_Missense_Mutation_p.P524T|LILRB1_ENST00000418536.2_Missense_Mutation_p.P507T|LILRB1_ENST00000434867.2_Missense_Mutation_p.P523T|LILRB1_ENST00000396321.2_Missense_Mutation_p.P523T|LILRB1_ENST00000462628.1_3'UTR|LILRB1_ENST00000427581.2_Missense_Mutation_p.P573T	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	523					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CAGGTCCAGCCCAGCTGCCGA	0.607000										HNSCC(37;0.09)			15	77					0.000422831	0.000697881	0.004007	1	0
RFX1	5989	broad.mit.edu	37	19	14094399	14094399	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:14094399T>G	ENST00000254325.4	-	3	562	c.328A>C	c.(328-330)Atg>Ctg	p.M110L		NM_002918.4	NP_002909.4	P22670	RFX1_HUMAN	regulatory factor X, 1 (influences HLA class II expression)	110					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			CTGGCCCGCATGGCACCTTCT	0.672000													3	10					0	0	0.004672	0	0
DMWD	1762	broad.mit.edu	37	19	46290016	46290016	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:46290016G>A	ENST00000270223.6	-	3	783	c.738C>T	c.(736-738)ccC>ccT	p.P246P	DMWD_ENST00000377735.3_Silent_p.P246P	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	246					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		CCGAGGCGCAGGGGTGGCTGA	0.627000													22	43					0	0	0.002299	0	0
ORC4	5000	broad.mit.edu	37	2	148696734	148696734	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:148696734C>A	ENST00000535373.1	-	12	1365	c.933G>T	c.(931-933)atG>atT	p.M311I	ORC4_ENST00000392857.4_Missense_Mutation_p.M311I|ORC4_ENST00000264169.2_Missense_Mutation_p.M311I|ORC4_ENST00000536575.1_Missense_Mutation_p.M227I|ORC4_ENST00000542387.1_Missense_Mutation_p.M94I|ORC4_ENST00000540442.1_Missense_Mutation_p.M237I|ORC4_ENST00000392858.1_Missense_Mutation_p.M311I	NM_001190879.2	NP_001177808.1	O43929	ORC4_HUMAN	origin recognition complex, subunit 4	311					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|nucleoside-triphosphatase activity|protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	14						CTTTCGAGTCCATGCTACACA	0.358000													14	31					2.32078e-09	4.44448e-09	0.003163	1	0
NEBL	10529	broad.mit.edu	37	10	21108419	21108419	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:21108419C>T	ENST00000377122.4	-	20	2385	c.1989G>A	c.(1987-1989)aaG>aaA	p.K663K	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	663					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CCGGAGTGGCCTTGTAGTTTT	0.438000													32	104					0	0	0.002096	0	0
TNFSF18	8995	broad.mit.edu	37	1	173010716	173010716	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:173010716C>T	ENST00000404377.3	-	3	391	c.391G>A	c.(391-393)Gat>Aat	p.D131N	RP1-15D23.2_ENST00000432694.1_RNA|TNFSF18_ENST00000239468.2_Missense_Mutation_p.D109N	NM_005092.3	NP_005083.2	Q9UNG2	TNF18_HUMAN	tumor necrosis factor (ligand) superfamily, member 18	131					anti-apoptosis|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)	9						GGAGCTACATCATTGTAGTTT	0.383000													40	92					0	0	0.001287	0	0
GRIN2A	2903	broad.mit.edu	37	16	9923416	9923416	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:9923416C>G	ENST00000396573.2	-	10	2180	c.1871G>C	c.(1870-1872)gGg>gCg	p.G624A	GRIN2A_ENST00000404927.2_Missense_Mutation_p.G624A|GRIN2A_ENST00000330684.3_Missense_Mutation_p.G624A|GRIN2A_ENST00000396575.2_Missense_Mutation_p.G624A|GRIN2A_ENST00000535259.1_Missense_Mutation_p.G467A|GRIN2A_ENST00000562109.1_Missense_Mutation_p.G624A	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	624					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCTGGTGGTCCCTTTAGGATT	0.493000													18	85					0	0	0.001523	0	0
SSTR4	6754	broad.mit.edu	37	20	23017238	23017238	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23017238C>A	ENST00000255008.3	+	1	1182	c.1118C>A	c.(1117-1119)cCa>cAa	p.P373Q	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	373					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity	p.P373Q(1)		breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GCCCTGCAACCAGAACCCGGC	0.667000													24	59					1.04121e-07	1.91016e-07	0.005443	1	0
SYCP1	6847	broad.mit.edu	37	1	115527424	115527424	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:115527424A>T	ENST00000369522.3	+	30	2878	c.2638A>T	c.(2638-2640)Aaa>Taa	p.K880*	SYCP1_ENST00000369518.1_Nonsense_Mutation_p.K880*|SYCP1_ENST00000477590.1_Intron	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	880					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGAAAGTAAAAAAAAGAGAAA	0.259000													31	66					0	0	0.003755	0	0
PTPRM	5797	broad.mit.edu	37	18	8379247	8379247	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:8379247G>T	ENST00000332175.8	+	26	4693	c.3656G>T	c.(3655-3657)tGc>tTc	p.C1219F	PTPRM_ENST00000400060.4_Missense_Mutation_p.C1233F|PTPRM_ENST00000444013.1_Missense_Mutation_p.C1006F|PTPRM_ENST00000580170.1_Missense_Mutation_p.C1232F|PTPRM_ENST00000400053.4_Missense_Mutation_p.C1157F	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1219	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				AAAAACCGGTGCATGGACATC	0.567000													35	153					1.07637e-12	2.19986e-12	0.004878	1	0
RP11-1407O15.2	0	broad.mit.edu	37	17	36352507	36352507	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:36352507G>A	ENST00000312412.4	-	11	1279	c.1280C>T	c.(1279-1281)tCt>tTt	p.S427F	RP11-1407O15.2_ENST00000544906.1_Missense_Mutation_p.S272F|TBC1D3_ENST00000537432.1_5'UTR																kidney(1)|lung(3)	4						ATCAACCTCAGATGGATGGCC	0.403000													7	26					0	0	0.004482	0	0
SELL	6402	broad.mit.edu	37	1	169673747	169673747	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:169673747G>T	ENST00000236147.4	-	5	927	c.767C>A	c.(766-768)cCa>cAa	p.P256Q	C1orf112_ENST00000498289.1_Intron|SELL_ENST00000463108.1_5'UTR	NM_000655.4	NP_000646.2	P14151	LYAM1_HUMAN	selectin L	243	Sushi 1.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	15	all_hematologic(923;0.208)					GTTTCCAAATGGTCCACAGGT	0.463000													3	3					0.004672	0.00755576	0.004672	1	0
PDZRN3	23024	broad.mit.edu	37	3	73433878	73433878	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:73433878C>A	ENST00000263666.4	-	10	1953	c.1839G>T	c.(1837-1839)ttG>ttT	p.L613F	PDZRN3_ENST00000462146.2_Missense_Mutation_p.L270F|PDZRN3_ENST00000479530.1_Missense_Mutation_p.L330F|PDZRN3_ENST00000466780.1_Missense_Mutation_p.L270F|PDZRN3_ENST00000535920.1_Missense_Mutation_p.L335F	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	613							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CGCCGCTGCCCAAGGTGTCCT	0.647000													25	36					3.01185e-09	5.70262e-09	0.003954	1	0
TRPM3	80036	broad.mit.edu	37	9	73240414	73240414	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:73240414C>A	ENST00000377105.1	-	13	1547	c.1193G>T	c.(1192-1194)gGt>gTt	p.G398V	TRPM3_ENST00000360823.2_Intron|TRPM3_ENST00000423814.3_Intron|TRPM3_ENST00000396280.5_Missense_Mutation_p.G398V|TRPM3_ENST00000357533.2_Missense_Mutation_p.G553V|TRPM3_ENST00000396292.4_Intron|TRPM3_ENST00000377111.2_Intron|TRPM3_ENST00000396285.1_Intron|TRPM3_ENST00000377110.2_Intron|TRPM3_ENST00000408909.2_Missense_Mutation_p.G398V|TRPM3_ENST00000358082.3_Intron|TRPM3_ENST00000377106.1_Intron	NM_024971.5|NM_206945.3	NP_079247.5|NP_996828.3	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	569						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						ATAGATCCAACCGAAACCTGG	0.284000													13	28					2.32078e-09	4.44448e-09	0.003163	1	0
TLE2	7089	broad.mit.edu	37	19	3015720	3015720	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:3015720C>G	ENST00000262953.6	-	9	871	c.609G>C	c.(607-609)gaG>gaC	p.E203D	TLE2_ENST00000590536.1_Missense_Mutation_p.E204D|TLE2_ENST00000591529.1_Missense_Mutation_p.E217D|TLE2_ENST00000587217.1_5'UTR|TLE2_ENST00000447365.2_5'UTR|TLE2_ENST00000443826.3_Missense_Mutation_p.E81D|TLE2_ENST00000455444.2_Missense_Mutation_p.E81D|TLE2_ENST00000426948.2_Missense_Mutation_p.E217D|TLE2_ENST00000586422.1_Intron	NM_003260.4	NP_003251.2	Q04725	TLE2_HUMAN	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	203	CCN domain.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGGTCGCTCCTCCTCCACGA	0.632000													8	12					0	0	0.000978	0	0
IGSF3	3321	broad.mit.edu	37	1	117142746	117142746	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:117142746G>C	ENST00000369486.3	-	7	2611	c.1846C>G	c.(1846-1848)Cga>Gga	p.R616G	IGSF3_ENST00000369483.1_Missense_Mutation_p.R636G|IGSF3_ENST00000318837.6_Missense_Mutation_p.R636G	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	616	Ig-like C2-type 5.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		ATGGCAGTTCGGGTTCGGAAG	0.627000													10	20					0	0	0.000443	0	0
TYK2	7297	broad.mit.edu	37	19	10475629	10475629	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:10475629C>T	ENST00000525621.1	-	8	1588	c.1107G>A	c.(1105-1107)ccG>ccA	p.P369P	TYK2_ENST00000529370.1_Silent_p.P369P|TYK2_ENST00000524462.1_Silent_p.P184P|TYK2_ENST00000264818.6_Silent_p.P369P	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	369	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GTGGCTCCCGCGGCCTGTCTG	0.617000													20	43					0	0	0.001523	0	0
KMT2D	8085	broad.mit.edu	37	12	49447314	49447314	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:49447314C>T	ENST00000301067.7	-	6	783	c.784G>A	c.(784-786)Gcc>Acc	p.A262T		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D									p.L260fs*8(1)									CGTTTGCGGGCAGTCAGAGCA	0.582000													5	11					0	0	0.000602	0	0
WFS1	7466	broad.mit.edu	37	4	6296916	6296916	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:6296916G>T	ENST00000226760.1	+	7	1031	c.861_splice	c.e7+1	p.K287_splice	WFS1_ENST00000503569.1_Splice_Site_p.K287_splice	NM_001145853.1|NM_006005.3	NP_001139325.1|NP_005996.2	O76024	WFS1_HUMAN	Wolfram syndrome 1 (wolframin)	287					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	21				Colorectal(103;0.0512)		TGCGTCTGAAGGTGAGTGACC	0.657000													24	45					3.80469e-20	8.98355e-20	0.001786	1	0
MUC6	4588	broad.mit.edu	37	11	1017714	1017714	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:1017714G>T	ENST00000421673.2	-	31	5137	c.5087C>A	c.(5086-5088)tCa>tAa	p.S1696*		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1696	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGAAGTGTGTGAATGTAGGGA	0.557000													72	883					5.10508e-28	1.2712e-27	0.003610	1	0
AVL9	23080	broad.mit.edu	37	7	32590986	32590986	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:32590986C>T	ENST00000318709.4	+	5	634	c.413C>T	c.(412-414)aCa>aTa	p.T138I	AVL9_ENST00000404479.1_Missense_Mutation_p.T138I|AVL9_ENST00000409301.1_Missense_Mutation_p.T138I	NM_015060.1	NP_055875.1	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	138						integral to membrane				endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						CAACTCATTACACATGCATAT	0.308000													16	102					0	0	0.003163	0	0
ATF1	466	broad.mit.edu	37	12	51213453	51213453	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:51213453A>G	ENST00000262053.3	+	7	729	c.707A>G	c.(706-708)gAa>gGa	p.E236G	ATF1_ENST00000539132.1_Missense_Mutation_p.E101G	NM_005171.4	NP_005162.1	P18846	ATF1_HUMAN	activating transcription factor 1	236					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(347)|FUS/ATF1(4)	breast(1)|large_intestine(1)|ovary(2)	4						AAGAAGAAAGAATATGTGAAA	0.308000			T	"""EWSR1, FUS"""	"""malignant melanoma of soft parts , angiomatoid fibrous histiocytoma """								21	26					0	0	0.002299	0	0
WDR43	23160	broad.mit.edu	37	2	29158393	29158393	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:29158393C>T	ENST00000407426.3	+	12	1500	c.1444C>T	c.(1444-1446)Ctt>Ttt	p.L482F		NM_015131.1	NP_055946.1	Q15061	WDR43_HUMAN	WD repeat domain 43	482						nucleolus				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	20	Acute lymphoblastic leukemia(172;0.155)					ACAGAAAGTACTTCAAACTAG	0.318000													10	39					0	0	0.000443	0	0
ACACA	31	broad.mit.edu	37	17	35468548	35468548	+	Silent	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:35468548T>G	ENST00000353139.5	-	52	6964	c.6483A>C	c.(6481-6483)gtA>gtC	p.V2161V	ACACA_ENST00000361253.5_Silent_p.V250V|ACACA_ENST00000394406.2_Silent_p.V2124V|ACACA_ENST00000360679.3_Silent_p.V2066V|ACACA_ENST00000335166.5_Silent_p.V2046V	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	2124	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ATTTGATTTCTACTGTCCCTT	0.458000													27	71					0	0	0.005443	0	0
GRID2	2895	broad.mit.edu	37	4	94006343	94006343	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:94006343C>A	ENST00000282020.4	+	3	700	c.442C>A	c.(442-444)Cca>Aca	p.P148T	GRID2_ENST00000505687.1_3'UTR|GRID2_ENST00000510992.1_Intron	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	148					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CTCAGTTCGCCCACCTGTCTA	0.478000													29	77					7.26314e-15	1.56407e-14	0.001271	1	0
ZNF704	619279	broad.mit.edu	37	8	81605276	81605276	+	Silent	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:81605276A>C	ENST00000327835.3	-	3	519	c.288T>G	c.(286-288)acT>acG	p.T96T	ZNF704_ENST00000520336.1_5'UTR	NM_001033723.2	NP_001028895.1	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	96						intracellular	zinc ion binding			lung(9)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			CCAAAGGGCTAGTCGACAAGC	0.527000													15	41					0	0	0.003163	0	0
RASGRP3	25780	broad.mit.edu	37	2	33741637	33741637	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:33741637T>C	ENST00000403687.3	+	4	839	c.99T>C	c.(97-99)taT>taC	p.Y33Y	RASGRP3_ENST00000407811.1_Silent_p.Y33Y|RASGRP3_ENST00000402538.3_Silent_p.Y33Y	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	33	N-terminal Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					ATAATAGTTATTTGCCAAGAA	0.328000													2	9					0	0	0.004672	0	0
LTBP1	4052	broad.mit.edu	37	2	33540329	33540329	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:33540329G>A	ENST00000404816.2	+	24	4076	c.3723G>A	c.(3721-3723)acG>acA	p.T1241T	LTBP1_ENST00000407925.1_Silent_p.T915T|LTBP1_ENST00000390003.4_Silent_p.T916T|LTBP1_ENST00000402934.1_Silent_p.T862T|LTBP1_ENST00000354476.3_Silent_p.T1242T|LTBP1_ENST00000272273.5_Silent_p.T181T|LTBP1_ENST00000418533.2_Silent_p.T915T|LTBP1_ENST00000404525.1_Silent_p.T862T			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1241	EGF-like 12; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				ATGGCCGTACGTGTGAAGGTA	0.448000													13	31					0	0	0.001855	0	0
LSM11	134353	broad.mit.edu	37	5	157181901	157181901	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:157181901G>T	ENST00000286307.5	+	4	768	c.712G>T	c.(712-714)Gaa>Taa	p.E238*		NM_173491.2	NP_775762.1	P83369	LSM11_HUMAN	LSM11, U7 small nuclear RNA associated	238					histone mRNA 3'-end processing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	histone pre-mRNA 3'end processing complex|nucleoplasm|U7 snRNP	protein binding|U7 snRNA binding			breast(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)	7	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTCCAAGAAGGAAGCAGATTC	0.423000													22	39					3.10358e-05	5.27872e-05	0.002299	1	0
TAS1R2	80834	broad.mit.edu	37	1	19168324	19168324	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:19168324T>A	ENST00000375371.3	-	5	1511	c.1490A>T	c.(1489-1491)aAg>aTg	p.K497M		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	497					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CTGGCACCTCTTGGAACACAT	0.587000													25	75					0	0	0.001061	0	0
UBAP2	55833	broad.mit.edu	37	9	33956140	33956140	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:33956140G>T	ENST00000379238.1	-	11	920	c.803C>A	c.(802-804)tCt>tAt	p.S268Y	UBAP2_ENST00000539807.1_Missense_Mutation_p.S23Y|UBAP2_ENST00000449054.1_Missense_Mutation_p.S268Y|UBAP2_ENST00000418786.2_Missense_Mutation_p.S215Y|UBAP2_ENST00000379239.4_Intron|UBAP2_ENST00000360802.1_Missense_Mutation_p.S268Y			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	268										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		CTTTGTTTCAGAAAGCTGTAT	0.353000													22	59					2.89027e-11	5.74333e-11	0.002299	1	0
LOC728323	728323	broad.mit.edu	37	2	243061153	243061153	+	RNA	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:243061153G>T	ENST00000456398.1	+	0	501																											ACCTTTAATCGGTTAGACTTC	0.368000													26	30					3.73988e-18	8.52948e-18	0.001061	1	0
AZI1	22994	broad.mit.edu	37	17	79176070	79176070	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:79176070C>A	ENST00000269392.4	-	7	1005	c.758G>T	c.(757-759)cGg>cTg	p.R253L	AZI1_ENST00000374782.3_Missense_Mutation_p.R253L|AZI1_ENST00000450824.2_Missense_Mutation_p.R253L|AZI1_ENST00000575907.1_Missense_Mutation_p.R253L|AZI1_ENST00000570482.2_5'UTR	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	253					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CACCTCCTTCCGCCTGGGCAA	0.652000													16	48					1.15088e-07	2.09412e-07	0.004007	1	0
CUBN	8029	broad.mit.edu	37	10	17126346	17126346	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:17126346T>A	ENST00000377833.4	-	17	2290	c.2225A>T	c.(2224-2226)cAg>cTg	p.Q742L		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	742	CUB 3.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTGTTCTCCCTGGGGCTGCTT	0.498000													21	41					0	0	0.001882	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125175132	125175132	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:125175132T>C	ENST00000431078.1	+	4	858	c.494T>C	c.(493-495)aTt>aCt	p.I165T		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	165	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		AGTGGGAAGATTGGCATGAGA	0.498000													3	16					0	0	0.004672	0	0
PKHD1	5314	broad.mit.edu	37	6	51750673	51750673	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:51750673C>A	ENST00000371117.3	-	45	7482	c.7207G>T	c.(7207-7209)Ggt>Tgt	p.G2403C	PKHD1_ENST00000340994.4_Missense_Mutation_p.G2403C	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2403					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					ACCTGGGCACCACCTGCACTT	0.388000													14	46					1.3612e-06	2.40699e-06	0.003163	1	0
TPO	7173	broad.mit.edu	37	2	1480964	1480964	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1480964C>A	ENST00000345913.4	+	8	1017	c.926C>A	c.(925-927)tCc>tAc	p.S309Y	TPO_ENST00000329066.4_Missense_Mutation_p.S309Y|TPO_ENST00000382201.3_Missense_Mutation_p.S309Y|TPO_ENST00000349624.3_Intron|TPO_ENST00000346956.3_Missense_Mutation_p.S309Y|TPO_ENST00000337415.3_Missense_Mutation_p.S309Y|TPO_ENST00000382198.1_Intron|TPO_ENST00000497517.2_Intron	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	309					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGGAACCTGTCCACGGCCAAC	0.706000													9	25					7.48243e-07	1.33843e-06	0.000443	1	0
HELZ	9931	broad.mit.edu	37	17	65162623	65162623	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:65162623C>T	ENST00000358691.5	-	15	2032	c.1866G>A	c.(1864-1866)atG>atA	p.M622I	HELZ_ENST00000580168.1_Missense_Mutation_p.M622I	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TGGTGGGAGTCATACTGATGT	0.363000													20	44					0	0	0.001216	0	0
WNT5B	81029	broad.mit.edu	37	12	1755062	1755062	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:1755062G>T	ENST00000397196.2	+	5	956	c.724G>T	c.(724-726)Ggg>Tgg	p.G242W	WNT5B_ENST00000542408.1_3'UTR|WNT5B_ENST00000545747.1_3'UTR|WNT5B_ENST00000537031.1_Missense_Mutation_p.G242W|WNT5B_ENST00000310594.3_Missense_Mutation_p.G242W	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	242					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			CCGCAAGGTCGGGGACCGGCT	0.662000													28	50					6.12954e-19	1.4288e-18	0.004656	1	0
MYBL2	4605	broad.mit.edu	37	20	42328423	42328423	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:42328423C>T	ENST00000217026.4	+	7	817	c.690C>T	c.(688-690)tcC>tcT	p.S230S	MYBL2_ENST00000396863.4_Silent_p.S206S	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	230						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ACTGGCCCTCCGTCCCTCCTA	0.488000													16	28					0	0	0.006122	0	0
TOP3B	8940	broad.mit.edu	37	22	22322027	22322027	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:22322027C>G	ENST00000398793.2	-	8	1234	c.800G>C	c.(799-801)cGg>cCg	p.R267P	TOP3B_ENST00000413067.2_5'UTR|TOP3B_ENST00000357179.5_Missense_Mutation_p.R267P	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	267					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		TGCGATCTCCCGGTCAAACAC	0.483000													33	65					0	0	0.003271	0	0
CCDC104	112942	broad.mit.edu	37	2	55756024	55756024	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:55756024A>T	ENST00000349456.4	+	4	441	c.293A>T	c.(292-294)cAa>cTa	p.Q98L	CCDC104_ENST00000403007.3_Missense_Mutation_p.Q98L|CCDC104_ENST00000407816.3_Missense_Mutation_p.Q98L|CCDC104_ENST00000339012.3_Missense_Mutation_p.Q123L|CCDC104_ENST00000406691.3_Missense_Mutation_p.Q98L			Q96G28	CC104_HUMAN	coiled-coil domain containing 104	98										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(2)|lung(1)|ovary(2)	14			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCCATTTTGCAACCTGTGTTG	0.363000													5	34					0	0	0.001168	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474516	140474516	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140474516G>T	ENST00000194155.4	+	1	290	c.142G>T	c.(142-144)Gcc>Tcc	p.A48S		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		48	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCTTTGTGGCCAATTTGTT	0.498000													13	49					1.05317e-09	2.03437e-09	0.002450	1	0
KRT18	3875	broad.mit.edu	37	12	53346565	53346565	+	Missense_Mutation	SNP	G	G	A	rs148580152		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:53346565G>A	ENST00000388835.3	+	7	1442	c.1232G>A	c.(1231-1233)cGc>cAc	p.R411H	KRT18_ENST00000550600.1_3'UTR|KRT18_ENST00000388837.2_Missense_Mutation_p.R411H	NM_000224.2	NP_000215.1	P05783	K1C18_HUMAN	keratin 18	411	Tail.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			central_nervous_system(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	11						ACCACCACCCGCCGGATAGTG	0.532000													24	48					0	0	0.002299	0	0
SLC12A1	6557	broad.mit.edu	37	15	48577336	48577336	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:48577336C>A	ENST00000396577.3	+	21	2734	c.2519C>A	c.(2518-2520)gCa>gAa	p.A840E	SLC12A1_ENST00000558405.1_Missense_Mutation_p.A840E|SLC12A1_ENST00000380993.3_Missense_Mutation_p.A840E	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	840					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GAGAGACTAGCATTGGAAGCG	0.373000													28	43					1.39806e-14	2.99775e-14	0.001512	1	0
AHNAK	79026	broad.mit.edu	37	11	62289778	62289778	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:62289778G>C	ENST00000378024.4	-	5	12385	c.12111C>G	c.(12109-12111)atC>atG	p.I4037M	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4037					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TGGGGCCCTTGATGTCAACTT	0.493000													92	249					0	0	0.003610	0	0
XKR4	114786	broad.mit.edu	37	8	56436507	56436507	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:56436507C>A	ENST00000327381.5	+	3	1774	c.1674C>A	c.(1672-1674)gaC>gaA	p.D558E		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	558						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			TTGTCAGCGACCGCGATCAGA	0.592000													19	56					5.35267e-07	9.60895e-07	0.000958	1	0
RBM14	10432	broad.mit.edu	37	11	66392979	66392979	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:66392979A>T	ENST00000310137.4	+	2	1771	c.1632A>T	c.(1630-1632)ccA>ccT	p.P544P	RBM14-RBM4_ENST00000412278.2_Intron|RBM4_ENST00000503028.2_Intron|RBM14_ENST00000409738.4_Intron|RBM4_ENST00000514361.3_Intron|RBM14-RBM4_ENST00000500635.2_Intron|RBM14_ENST00000393979.3_Intron	NM_006328.3	NP_006319.1	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	544	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						GCGGCCAGCCAGGCAATGCCT	0.657000													20	46					0	0	0.001216	0	0
SERINC5	256987	broad.mit.edu	37	5	79470855	79470855	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:79470855C>T	ENST00000507668.2	-	5	623	c.473G>A	c.(472-474)gGa>gAa	p.G158E	SERINC5_ENST00000512721.1_Missense_Mutation_p.G158E|SERINC5_ENST00000512972.2_Missense_Mutation_p.G158E|SERINC5_ENST00000509193.1_Missense_Mutation_p.G158E	NM_001174071.1|NM_178276.5	NP_001167542.1|NP_840060.1	Q86VE9	SERC5_HUMAN	serine incorporator 5	158					phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|kidney(1)|lung(3)|ovary(1)	8		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		TCCGACGGCTCCCACATAGCG	0.468000													5	8					0	0	0.001168	0	0
NDN	4692	broad.mit.edu	37	15	23931753	23931753	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:23931753G>T	ENST00000331837.4	-	1	697	c.612C>A	c.(610-612)ggC>ggA	p.G204G		NM_002487.2	NP_002478.1	Q99608	NECD_HUMAN	necdin, melanoma antigen (MAGE) family member	204	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|skin(1)	39		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		TCTCTCTGGCGCCGCGGCCCT	0.657000									Prader-Willi syndrome				10	25					2.17888e-05	3.71854e-05	0.000443	1	0
ADAMTS9	56999	broad.mit.edu	37	3	64608244	64608244	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:64608244C>T	ENST00000498707.1	-	17	2750	c.2408G>A	c.(2407-2409)gGt>gAt	p.G803D	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.G775D	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	803	Spacer.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CAAGAATTCACCTTTACTGCT	0.403000													17	20					0	0	0.004990	0	0
FBLN7	129804	broad.mit.edu	37	2	112944822	112944822	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:112944822G>T	ENST00000331203.2	+	8	1330	c.1059G>T	c.(1057-1059)acG>acT	p.T353T	FBLN7_ENST00000409450.3_Silent_p.T307T|FBLN7_ENST00000409667.3_Silent_p.T219T|FBLN7_ENST00000409903.1_Intron	NM_001128165.1|NM_153214.2	NP_001121637.1|NP_694946.2	Q53RD9	FBLN7_HUMAN	fibulin 7	353					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						CGCCCATCACGCTCTTCCGCA	0.647000													38	103					4.14481e-20	9.7522e-20	0.001287	1	0
PCDHA12	56137	broad.mit.edu	37	5	140255363	140255363	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140255363C>A	ENST00000398631.2	+	1	306	c.306C>A	c.(304-306)tgC>tgA	p.C102*	PCDHA9_ENST00000532602.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGAGTGCAGTATCCACC	0.552000													73	186					3.58576e-35	9.14438e-35	0.003610	1	0
TBCD	6904	broad.mit.edu	37	17	80885196	80885196	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:80885196C>T	ENST00000355528.4	+	29	2736	c.2606C>T	c.(2605-2607)aCc>aTc	p.T869I	TBCD_ENST00000539345.2_Missense_Mutation_p.T869I	NM_005993.4	NP_005984.3	Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D	869					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			GACGTGGGCACCTGGTACGTA	0.572000													6	15					0	0	0.001984	0	0
ROBO4	54538	broad.mit.edu	37	11	124765699	124765699	+	Silent	SNP	C	C	G	rs143848676		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:124765699C>G	ENST00000306534.3	-	5	1274	c.789G>C	c.(787-789)gcG>gcC	p.A263A	ROBO4_ENST00000533054.1_Silent_p.A118A|ROBO4_ENST00000526899.1_5'UTR	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	263	Fibronectin type-III 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		TGAGCCACACCGCCGGTCTAG	0.597000													36	46					0	0	0.004878	0	0
DNAH11	8701	broad.mit.edu	37	7	21628907	21628907	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:21628907T>A	ENST00000328843.6	+	12	2086	c.2055T>A	c.(2053-2055)cgT>cgA	p.R685R	DNAH11_ENST00000409508.3_Silent_p.R685R			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	685	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TTGAAAGTCGTATCTATAATG	0.333000									Kartagener syndrome				24	46					0	0	0.003330	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42442599	42442599	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:42442599T>G	ENST00000397272.3	-	9	948	c.857A>C	c.(856-858)gAg>gCg	p.E286A	PLA2G4F_ENST00000382396.4_Missense_Mutation_p.E286A	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	286					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		ACACTGTTCCTCCTGGCCTAG	0.627000													9	14					0	0	0.000443	0	0
OR51V1	283111	broad.mit.edu	37	11	5221348	5221348	+	Missense_Mutation	SNP	G	G	A	rs151191536		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:5221348G>A	ENST00000321255.1	-	1	582	c.583C>T	c.(583-585)Cgc>Tgc	p.R195C		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGGCTAAGCGGAGAAGATCC	0.398000													11	39					0	0	0.000978	0	0
KCNMA1	3778	broad.mit.edu	37	10	78729807	78729807	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:78729807G>C	ENST00000286627.5	-	19	3063	c.2111C>G	c.(2110-2112)tCa>tGa	p.S704*	KCNMA1_ENST00000372443.1_Nonsense_Mutation_p.S704*|RP11-443A13.5_ENST00000598613.1_RNA|KCNMA1_ENST00000404771.3_Nonsense_Mutation_p.S762*|KCNMA1_ENST00000404857.1_Nonsense_Mutation_p.S704*|RP11-443A13.5_ENST00000600782.1_RNA|KCNMA1_ENST00000406533.3_Nonsense_Mutation_p.S766*|RP11-443A13.5_ENST00000458661.2_RNA|KCNMA1_ENST00000354353.5_Nonsense_Mutation_p.S765*|KCNMA1_ENST00000372440.1_Nonsense_Mutation_p.S704*|KCNMA1_ENST00000286628.8_Nonsense_Mutation_p.S762*	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	699					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TGATAGTGTTGACGGCTGCTC	0.483000													22	84					0	0	0.002780	0	0
MSI2	124540	broad.mit.edu	37	17	55607074	55607074	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:55607074A>G	ENST00000284073.2	+	7	652	c.443A>G	c.(442-444)aAc>aGc	p.N148S	MSI2_ENST00000322684.3_Missense_Mutation_p.N144S|MSI2_ENST00000416426.2_Missense_Mutation_p.N126S|MSI2_ENST00000442934.2_Missense_Mutation_p.N87S|MSI2_ENST00000579505.1_3'UTR|MSI2_ENST00000579180.1_Missense_Mutation_p.N44S	NM_138962.2	NP_620412.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	148	RRM 2.					cytoplasm	nucleotide binding|RNA binding	p.N144S(1)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		AAAACTACCAACAGGCACAGA	0.428000			T	HOXA9	CML								13	30					0	0	0.001855	0	0
CFTR	1080	broad.mit.edu	37	7	117246788	117246788	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:117246788C>A	ENST00000003084.6	+	18	3101	c.2969C>A	c.(2968-2970)aCc>aAc	p.T990N	CFTR_ENST00000454343.1_Missense_Mutation_p.T929N|AC000111.6_ENST00000456270.1_RNA	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	990	ABC transmembrane type-1 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CTGCCTCTTACCATATTTGAC	0.289000									Cystic Fibrosis				23	89					3.28513e-13	6.76925e-13	0.003954	1	0
GBA3	57733	broad.mit.edu	37	4	22729135	22729135	+	RNA	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:22729135G>T	ENST00000503442.1	+	0	149				GBA3_ENST00000508166.1_RNA|GBA3_ENST00000511446.1_RNA	NM_001128432.2	NP_001121904.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TTCAGGTCACGGGCCAGCTTT	0.473000													87	213					6.20368e-34	1.57605e-33	0.003610	1	0
GOLGA2P9	440518	broad.mit.edu	37	19	22785476	22785476	+	RNA	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:22785476C>A	ENST00000600260.1	+	0	1565					NR_033899.1																						AACATCGCTGCATCCAGCTCT	0.607000													24	70					7.07758e-08	1.30199e-07	0.004656	1	0
F9	2158	broad.mit.edu	37	X	138642993	138642993	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:138642993G>A	ENST00000218099.2	+	7	824	c.817G>A	c.(817-819)Gtt>Att	p.V273I	F9_ENST00000394090.2_Missense_Mutation_p.V235I	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	273	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TGAAACTGGTGTTAAAATTAC	0.368000													7	42					0	0	0.001984	0	0
PAPPA	5069	broad.mit.edu	37	9	118950331	118950331	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:118950331G>T	ENST00000328252.3	+	2	1683	c.1314G>T	c.(1312-1314)ggG>ggT	p.G438G		NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	438	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						ACGACGGCGGGGATTGCCGCC	0.597000													17	62					1.45105e-14	3.10807e-14	0.006122	1	0
SOGA3	387104	broad.mit.edu	37	6	127836029	127836029	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:127836029C>A	ENST00000556132.1	-	3	2129	c.1265G>T	c.(1264-1266)cGc>cTc	p.R422L	SOGA3_ENST00000525778.1_Missense_Mutation_p.R422L|SOGA3_ENST00000481848.2_Missense_Mutation_p.R422L|SOGA3_ENST00000368268.2_Missense_Mutation_p.R422L|SOGA3_ENST00000465909.2_Missense_Mutation_p.R422L	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	422						integral to membrane											CTGGGCGTAGCGGAGCCTTTT	0.657000													23	63					3.01185e-09	5.70262e-09	0.003954	1	0
MASP2	10747	broad.mit.edu	37	1	11090242	11090242	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:11090242A>T	ENST00000400897.3	-	10	1303	c.1288T>A	c.(1288-1290)Tgt>Agt	p.C430S	RP4-635E18.8_ENST00000607145.1_RNA	NM_006610.3	NP_006601.2	O00187	MASP2_HUMAN	mannan-binding lectin serine peptidase 2	430	Sushi 2.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			biliary_tract(1)|endometrium(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		CCAGGCTCACAGACTGGGAGT	0.438000													45	33					0	0	0.002852	0	0
UTP11L	51118	broad.mit.edu	37	1	38484769	38484769	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:38484769T>A	ENST00000373014.4	+	5	442	c.381T>A	c.(379-381)gaT>gaA	p.D127E	UTP11L_ENST00000537711.1_Missense_Mutation_p.D127E|UTP11L_ENST00000488453.1_3'UTR	NM_016037.3	NP_057121.2	Q9Y3A2	UTP11_HUMAN	UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)	127					induction of apoptosis|nerve growth factor receptor signaling pathway|nervous system development|rRNA processing	cytoplasm|extracellular space|nucleolus|small-subunit processome	protein binding			NS(1)|cervix(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				ATCTGCTGGATTTCCAGGGGA	0.378000													34	18					0	0	0.002836	0	0
TESK1	7016	broad.mit.edu	37	9	35609311	35609311	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35609311C>T	ENST00000336395.5	+	10	1703	c.1453C>T	c.(1453-1455)Cag>Tag	p.Q485*	TESK1_ENST00000498522.1_3'UTR	NM_006285.2	NP_006276.2	Q15569	TESK1_HUMAN	testis-specific kinase 1	485					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	27			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCCAGCGCCCCAGCTGCCTCT	0.647000													23	59					0	0	0.003330	0	0
ZNF254	9534	broad.mit.edu	37	19	24309076	24309076	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:24309076C>T	ENST00000357002.4	+	4	389	c.274C>T	c.(274-276)Caa>Taa	p.Q92*	ZNF254_ENST00000342944.6_Nonsense_Mutation_p.Q7*	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	92					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				TCATTTTGCTCAAGACCTTTG	0.308000													7	30					0	0	0.001984	0	0
OR8B8	26493	broad.mit.edu	37	11	124310451	124310451	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:124310451G>A	ENST00000328064.2	-	1	603	c.531C>T	c.(529-531)taC>taT	p.Y177Y		NM_012378.1	NP_036510.1	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B, member 8	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TGTCACACATGTAGTGGTTGA	0.502000													26	54					0	0	0.003330	0	0
C22orf42	150297	broad.mit.edu	37	22	32555017	32555017	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:32555017C>G	ENST00000382097.3	-	1	258	c.186G>C	c.(184-186)caG>caC	p.Q62H		NM_001010859.1	NP_001010859.1	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	62										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	24						GGCTGAGGTACTGCATGAGTT	0.537000													61	174					0	0	0.003610	0	0
ART1	417	broad.mit.edu	37	11	3681167	3681167	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:3681167C>A	ENST00000250693.1	+	3	519	c.418C>A	c.(418-420)Cgc>Agc	p.R140S		NM_004314.2	NP_004305.2	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1	140					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			endometrium(1)|large_intestine(2)|liver(1)|lung(3)|skin(1)	8		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	TGAGGCGGGCCGCTCCCGGGC	0.667000													24	40					2.39556e-15	5.20335e-15	0.002780	1	0
PKD1	5310	broad.mit.edu	37	16	2167056	2167056	+	Splice_Site	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:2167056T>C	ENST00000262304.4	-	7	1594		c.e7-2		PKD1_ENST00000423118.1_Splice_Site	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)						calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TCTAGGCTCCTGGGGGCGGGT	0.682000													9	15					0	0	0.001368	0	0
NLRP4	147945	broad.mit.edu	37	19	56372754	56372754	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:56372754C>A	ENST00000301295.6	+	4	2281	c.1859C>A	c.(1858-1860)tCg>tAg	p.S620*	NLRP4_ENST00000587891.1_Nonsense_Mutation_p.S545*|NLRP4_ENST00000346986.5_Nonsense_Mutation_p.S620*	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	620							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GACCACAGGTCGGATTACAGC	0.552000													16	25					1.5739e-10	3.08478e-10	0.004007	1	0
SNHG14	104472715	broad.mit.edu	37	15	25417853	25417853	+	RNA	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:25417853T>C	ENST00000549301.1	+	0	503				SNORD115-2_ENST00000362842.1_RNA|SNHG14_ENST00000553149.1_RNA																							AATAGGATTATGCTGAGGCCC	0.522000													100	107					0	0	0.003610	0	0
PNKP	11284	broad.mit.edu	37	19	50364538	50364538	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:50364538C>A	ENST00000322344.3	-	17	1642	c.1533G>T	c.(1531-1533)ctG>ctT	p.L511L	PNKP_ENST00000596014.1_Silent_p.L511L|PNKP_ENST00000600573.1_Silent_p.L480L|PNKP_ENST00000600910.1_3'UTR	NM_007254.3	NP_009185.2	Q96T60	PNKP_HUMAN	polynucleotide kinase 3'-phosphatase	511					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|urinary_tract(1)	19		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		ACAGCCGCCCCAGCCTCGGCT	0.622000								Other BER factors					45	80					1.8453e-21	4.43004e-21	0.002522	1	0
NCKAP5	344148	broad.mit.edu	37	2	133540264	133540264	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:133540264G>C	ENST00000409261.1	-	14	4493	c.4120C>G	c.(4120-4122)Cca>Gca	p.P1374A	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.P1374A	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1374							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TCAGACTTTGGAGGGATCCTC	0.622000													15	30					0	0	0.004007	0	0
RXRG	6258	broad.mit.edu	37	1	165377463	165377463	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:165377463C>A	ENST00000359842.5	-	8	1441		c.e8+1			NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma						regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	AGGGCGGTTACCTGGGTTAAA	0.517000													34	66					2.05212e-20	4.86832e-20	0.005524	1	0
NAV2	89797	broad.mit.edu	37	11	20066745	20066745	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:20066745G>T	ENST00000396085.1	+	14	3792	c.3431G>T	c.(3430-3432)aGc>aTc	p.S1144I	NAV2_ENST00000540292.1_Missense_Mutation_p.S1098I|NAV2_ENST00000533917.1_Missense_Mutation_p.S230I|NAV2-AS2_ENST00000533767.1_RNA|NAV2_ENST00000311043.8_Missense_Mutation_p.S230I|NAV2_ENST00000396087.3_Missense_Mutation_p.S1167I|NAV2_ENST00000360655.4_Missense_Mutation_p.S1080I|NAV2_ENST00000349880.4_Missense_Mutation_p.S1144I|NAV2_ENST00000527559.2_Missense_Mutation_p.S1096I	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1167						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						ACTGTCACCAGCAGGTCAGCC	0.572000													19	79					9.95505e-16	2.18597e-15	0.002299	1	0
OR52B2	255725	broad.mit.edu	37	11	6191434	6191434	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:6191434G>T	ENST00000530810.1	-	1	204	c.123C>A	c.(121-123)gtC>gtA	p.V41V	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTTTCCCAGGACTGCAGTGA	0.478000													22	71					7.45023e-12	1.49526e-11	0.001523	1	0
TNS3	64759	broad.mit.edu	37	7	47474985	47474985	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:47474985C>T	ENST00000398879.1	-	8	585	c.219G>A	c.(217-219)tgG>tgA	p.W73*	TNS3_ENST00000442536.2_Nonsense_Mutation_p.W73*|TNS3_ENST00000458317.2_Nonsense_Mutation_p.W73*|TNS3_ENST00000311160.9_Nonsense_Mutation_p.W73*|TNS3_ENST00000355730.3_Nonsense_Mutation_p.W73*			Q68CZ2	TENS3_HUMAN	tensin 3	73	Phosphatase tensin-type.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						GGAGCTCTGGCCAGCCCACAT	0.517000													25	81					0	0	0.004656	0	0
PHF20L1	51105	broad.mit.edu	37	8	133816972	133816972	+	Silent	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:133816972T>G	ENST00000395386.2	+	8	1133	c.834T>G	c.(832-834)ctT>ctG	p.L278L	PHF20L1_ENST00000395374.1_Silent_p.L117L|PHF20L1_ENST00000395382.3_Silent_p.L148L|PHF20L1_ENST00000395383.1_Silent_p.L282L|PHF20L1_ENST00000395379.1_Silent_p.L278L|PHF20L1_ENST00000337920.4_Silent_p.L252L|PHF20L1_ENST00000315808.10_Silent_p.L278L|PHF20L1_ENST00000220847.7_5'UTR|PHF20L1_ENST00000395390.2_Silent_p.L253L|PHF20L1_ENST00000395376.1_Silent_p.L283L	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	278							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GAGCTCGACTTAACAAGATTA	0.343000													20	52					0	0	0.001882	0	0
BDP1	55814	broad.mit.edu	37	5	70819984	70819984	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:70819984G>T	ENST00000358731.4	+	25	5869	c.5606G>T	c.(5605-5607)cGg>cTg	p.R1869L	BDP1_ENST00000380675.2_Missense_Mutation_p.R6L	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	1869					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding	p.R1869L(1)		NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GTGACTCTTCGGGCTTCCCAG	0.468000													36	94					2.26627e-22	5.49325e-22	0.001706	1	0
RBM18	92400	broad.mit.edu	37	9	125004254	125004254	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:125004254T>G	ENST00000417201.3	-	6	622	c.482A>C	c.(481-483)tAt>tCt	p.Y161S	RBM18_ENST00000483428.1_5'UTR	NM_033117.3	NP_149108.1	Q96H35	RBM18_HUMAN	RNA binding motif protein 18	161							nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)	7						CGCTGCTGGATACTCTGCATC	0.408000													18	62					0	0	0.004990	0	0
PHRF1	57661	broad.mit.edu	37	11	608998	608998	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:608998G>T	ENST00000264555.5	+	14	3670	c.3542G>T	c.(3541-3543)cGt>cTt	p.R1181L	PHRF1_ENST00000533464.1_Missense_Mutation_p.R1177L|PHRF1_ENST00000413872.2_Missense_Mutation_p.R1179L|PHRF1_ENST00000416188.2_Missense_Mutation_p.R1180L	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1181	Arg-rich.						RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						CCTCGGTCCCGTGAGAAGTGG	0.706000													4	13					0.00024832	0.000412224	0.000248	1	0
SPNS3	201305	broad.mit.edu	37	17	4350211	4350211	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:4350211G>A	ENST00000355530.2	+	5	855	c.575G>A	c.(574-576)gGg>gAg	p.G192E	SPNS3_ENST00000333476.2_Missense_Mutation_p.G65E|SPNS3_ENST00000576069.1_3'UTR	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	192					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						TACGTGCTGGGGTCGGCTGTG	0.652000													21	37					0	0	0.002780	0	0
GUCY2C	2984	broad.mit.edu	37	12	14796620	14796620	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:14796620G>T	ENST00000261170.3	-	17	1954	c.1818C>A	c.(1816-1818)tcC>tcA	p.S606S		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	606	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						CTGTCTTACTGGAGTGCAGAT	0.373000													20	89					2.37509e-13	4.91931e-13	0.001523	1	0
FAM155A	728215	broad.mit.edu	37	13	108518792	108518792	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:108518792C>A	ENST00000375915.2	-	1	291	c.153G>T	c.(151-153)ctG>ctT	p.L51L		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	51						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						GATCAGAGAGCAGGACTGTGA	0.602000													39	80					2.75727e-19	6.45723e-19	0.004878	1	0
SLC9A9	285195	broad.mit.edu	37	3	143292939	143292939	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:143292939C>A	ENST00000316549.6	-	8	1199	c.991G>T	c.(991-993)Ggc>Tgc	p.G331C		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	331					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity	p.G331S(1)		breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						CCTGTTAGGCCGGCAGCCTCG	0.537000													9	66					0.000274275	0.000453435	0.004482	1	0
CHRFAM7A	89832	broad.mit.edu	37	15	30665184	30665184	+	Missense_Mutation	SNP	C	C	A	rs144150663		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:30665184C>A	ENST00000397827.3	-	5	826	c.52G>T	c.(52-54)Gtg>Ttg	p.V18L	CHRFAM7A_ENST00000299847.2_Missense_Mutation_p.V109L|CHRFAM7A_ENST00000401522.3_Missense_Mutation_p.V18L	NM_148911.1	NP_683709.1	Q494W8	CRFM7_HUMAN	CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion	109						integral to membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity			large_intestine(3)|lung(1)|skin(2)	6		all_lung(180;3.42e-11)|Breast(32;0.000153)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		GGCTTACCCACTAGGTCCCAT	0.502000													41	84					1.00001e-27	2.48393e-27	0.002222	1	0
CCDC19	25790	broad.mit.edu	37	1	159850454	159850454	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:159850454G>A	ENST00000426543.2	-	8	1134	c.679C>T	c.(679-681)Caa>Taa	p.Q227*	CCDC19_ENST00000476696.1_5'UTR|CCDC19_ENST00000368099.4_Nonsense_Mutation_p.Q312*			Q9UL16	CCD19_HUMAN	coiled-coil domain containing 19	312						mitochondrion|soluble fraction				endometrium(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	26	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			ATCTCAGCTTGCATCTTCAGT	0.468000													16	65					0	0	0.004007	0	0
PCLO	27445	broad.mit.edu	37	7	82451863	82451863	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:82451863C>A	ENST00000423517.2	-	20	15076	c.14739G>T	c.(14737-14739)ggG>ggT	p.G4913G	PCLO_ENST00000426442.2_5'UTR|PCLO_ENST00000333891.8_Silent_p.G4913G	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4775					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTATGGCAGCCCCTGCATCTT	0.498000													71	176					3.31162e-33	8.39194e-33	0.003610	1	0
HOXA7	3204	broad.mit.edu	37	7	27196162	27196162	+	Translation_Start_Site	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:27196162C>T	ENST00000242159.3	-	1	136	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_006896.3	NP_008827.2	P31268	HXA7_HUMAN	homeobox A7	1					angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding			endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|urinary_tract(1)	16						ACGAAGAACTCATAATTTTGA	0.443000													30	97					0	0	0.002096	0	0
ASTN2	23245	broad.mit.edu	37	9	119976723	119976723	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:119976723C>A	ENST00000313400.4	-	3	1029	c.929G>T	c.(928-930)cGc>cTc	p.R310L	ASTN2_ENST00000373996.3_Missense_Mutation_p.R310L|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Missense_Mutation_p.R310L			O75129	ASTN2_HUMAN	astrotactin 2	310						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CTCGTCCTCGCGGGAGACATG	0.577000													28	93					2.65835e-16	5.92153e-16	0.001271	1	0
TFR2	7036	broad.mit.edu	37	7	100225246	100225246	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:100225246A>T	ENST00000462107.1	-	16	2008	c.1721T>A	c.(1720-1722)tTc>tAc	p.F574Y	TFR2_ENST00000544242.1_Missense_Mutation_p.F115Y|TFR2_ENST00000431692.1_3'UTR|TFR2_ENST00000223051.3_Missense_Mutation_p.F574Y			Q9UP52	TFR2_HUMAN	transferrin receptor 2	574					cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					AAAGGCCGTGAAGGAATAGGC	0.632000													9	39					0	0	0.000443	0	0
MYH8	4626	broad.mit.edu	37	17	10304018	10304018	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10304018G>A	ENST00000403437.2	-	27	3518	c.3424C>T	c.(3424-3426)Ctc>Ttc	p.L1142F	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1142					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TCCCGGGAGAGGTCAGAGCGC	0.582000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				48	119					0	0	0.003610	0	0
OR2C3	81472	broad.mit.edu	37	1	247695520	247695520	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247695520A>T	ENST00000366487.3	-	2	655	c.294T>A	c.(292-294)tgT>tgA	p.C98*	GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000527541.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			ACTGGACCACACACCCTCCAT	0.577000													18	51					0	0	0.006122	0	0
REG1P	5969	broad.mit.edu	37	2	79364147	79364147	+	RNA	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:79364147C>A	ENST00000444841.1	-	0	285																											AAGGACAGCACAGAAATGTCC	0.463000													7	27					8.12818e-05	0.000136171	0.001984	1	0
GYPB	2994	broad.mit.edu	37	4	144920591	144920591	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:144920591G>T	ENST00000283126.7	-	3	203	c.148C>A	c.(148-150)Caa>Aaa	p.Q50K	GYPB_ENST00000502664.1_Missense_Mutation_p.Q50K|RP11-673E1.4_ENST00000506982.1_RNA|GYPB_ENST00000513128.1_Missense_Mutation_p.Q17K|GYPB_ENST00000510196.2_5'UTR|GYPB_ENST00000429670.2_Missense_Mutation_p.Q50K					glycophorin B (MNS blood group)											breast(1)|large_intestine(2)|skin(1)	4	all_hematologic(180;0.158)					TGGACAAGTTGTCCCGTTTCT	0.328000													4	11					0.00024832	0.000412224	0.000248	1	0
LAMB4	22798	broad.mit.edu	37	7	107746424	107746424	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:107746424A>G	ENST00000388781.3	-	8	791	c.708T>C	c.(706-708)ctT>ctC	p.L236L	LAMB4_ENST00000205386.4_Silent_p.L236L|LAMB4_ENST00000388780.3_Silent_p.L236L|LAMB4_ENST00000414450.2_Silent_p.L236L	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	236	Laminin N-terminal.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						AAGCATCCCCAAGGGTGTGGA	0.418000													16	42					0	0	0.004990	0	0
PABPC3	5042	broad.mit.edu	37	13	25671150	25671150	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:25671150C>A	ENST00000281589.3	+	1	851	c.814C>A	c.(814-816)Cgg>Agg	p.R272R		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	272					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AAAAGTGGAACGGCAGACGGA	0.398000													30	37					7.26314e-15	1.56407e-14	0.001271	1	0
MYOCD	93649	broad.mit.edu	37	17	12620739	12620739	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:12620739G>T	ENST00000425538.1	+	4	453		c.e4+1		MYOCD_ENST00000343344.4_Splice_Site|RP11-746E8.1_ENST00000578952.1_lincRNA	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin						cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ATACTCCAAGGTAAGGCTGCA	0.443000													7	23					0.00198382	0.00323176	0.001984	1	0
CCDC38	120935	broad.mit.edu	37	12	96312654	96312654	+	Splice_Site	SNP	C	C	A	rs139084164		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:96312654C>A	ENST00000344280.3	-	3	695	c.138_splice	c.e3+1	p.T46_splice		NM_182496.2	NP_872302.2	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	46										breast(1)|endometrium(2)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TAAACTTTACCGTTTCCTTTG	0.363000													14	46					1.15088e-07	2.09412e-07	0.004007	1	0
KRT25	147183	broad.mit.edu	37	17	38910665	38910665	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:38910665C>T	ENST00000312150.4	-	2	545	c.485G>A	c.(484-486)aGg>aAg	p.R162K		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	162	Coil 1B.|Rod.					cytoplasm|intermediate filament	structural molecule activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				AGCTGTAAGCCTGGCATTATC	0.393000													27	73					0	0	0.001512	0	0
APOB	338	broad.mit.edu	37	2	21230042	21230042	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:21230042T>C	ENST00000233242.1	-	26	9825	c.9698A>G	c.(9697-9699)tAc>tGc	p.Y3233C		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3233	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCAGCTTTGTACTTATCAAA	0.363000													19	27					0	0	0.000958	0	0
GREB1	9687	broad.mit.edu	37	2	11702672	11702672	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:11702672C>G	ENST00000381486.2	+	3	541	c.241C>G	c.(241-243)Ctg>Gtg	p.L81V	GREB1_ENST00000381483.2_Missense_Mutation_p.L81V|GREB1_ENST00000263834.5_Missense_Mutation_p.L81V|GREB1_ENST00000389825.3_5'UTR|GREB1_ENST00000234142.5_Missense_Mutation_p.L81V	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	81						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CCCTTTCCAGCTGCACCCTCT	0.612000													29	87					0	0	0.002096	0	0
PYGL	5836	broad.mit.edu	37	14	51381466	51381466	+	Missense_Mutation	SNP	G	G	T	rs113993980		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:51381466G>T	ENST00000216392.7	-	12	1803	c.1471C>A	c.(1471-1473)Cgc>Agc	p.R491S	PYGL_ENST00000544180.2_Missense_Mutation_p.R457S|PYGL_ENST00000532462.1_Missense_Mutation_p.R491S	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	491					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	AGGAGCCAGCGCCTTGGAGTG	0.498000													17	57					2.35188e-11	4.70142e-11	0.006122	1	0
ROBO4	54538	broad.mit.edu	37	11	124756439	124756439	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:124756439G>C	ENST00000306534.3	-	16	3200	c.2715C>G	c.(2713-2715)caC>caG	p.H905Q	RP11-664I21.5_ENST00000524453.1_RNA|ROBO4_ENST00000533054.1_Missense_Mutation_p.H760Q	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	905					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CCCGGGCAAAGTGAGCATCAG	0.602000													13	51					0	0	0.001368	0	0
AKAP12	9590	broad.mit.edu	37	6	151673277	151673277	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:151673277T>A	ENST00000402676.2	+	4	3991	c.3751T>A	c.(3751-3753)Tca>Aca	p.S1251T	AKAP12_ENST00000253332.1_Missense_Mutation_p.S1251T|AKAP12_ENST00000359755.5_Missense_Mutation_p.S1146T|AKAP12_ENST00000354675.6_Missense_Mutation_p.S1153T	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	1251					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		TAAAGAGGTGTCAGTGGAAAC	0.438000													11	30					0	0	0.000673	0	0
UNC79	57578	broad.mit.edu	37	14	94038416	94038416	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:94038416C>G	ENST00000553484.1	+	15	2086	c.1932C>G	c.(1930-1932)ttC>ttG	p.F644L	UNC79_ENST00000555664.1_Missense_Mutation_p.F644L|UNC79_ENST00000393151.2_Missense_Mutation_p.F644L|UNC79_ENST00000256339.4_Missense_Mutation_p.F467L			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	644						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TAAAAGAATTCAGGGAAGTAT	0.398000													12	40					0	0	0.001368	0	0
SYNE1	23345	broad.mit.edu	37	6	152529267	152529267	+	Missense_Mutation	SNP	C	C	A	rs149366576		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:152529267C>A	ENST00000367255.5	-	125	23265	c.22664G>T	c.(22663-22665)cGg>cTg	p.R7555L	SYNE1_ENST00000448038.1_Missense_Mutation_p.R7484L|SYNE1_ENST00000265368.4_Missense_Mutation_p.R7555L|SYNE1_ENST00000356820.4_Missense_Mutation_p.R2079L|SYNE1_ENST00000423061.1_Missense_Mutation_p.R7484L|SYNE1_ENST00000341594.5_Missense_Mutation_p.R7167L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7555					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AATGATCCCCCGCCTCTGCTG	0.488000										HNSCC(10;0.0054)			30	53					2.61193e-14	5.55312e-14	0.001786	1	0
NUAK1	9891	broad.mit.edu	37	12	106466568	106466568	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:106466568C>G	ENST00000261402.2	-	5	2012	c.633G>C	c.(631-633)acG>acC	p.T211T		NM_014840.2	NP_055655.1	O60285	NUAK1_HUMAN	NUAK family, SNF1-like kinase, 1	211	Protein kinase.						ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37						TCCCACAAAACGTTTGTAAGA	0.488000													21	50					0	0	0.001216	0	0
EPHA8	2046	broad.mit.edu	37	1	22919856	22919856	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:22919856G>A	ENST00000166244.3	+	6	1425	c.1353G>A	c.(1351-1353)gcG>gcA	p.A451A		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	451	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AAGAGCGGGCGGGGCAGACCA	0.657000													3	3					0	0	0.000602	0	0
SPANXD	64648	broad.mit.edu	37	X	140785676	140785676	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:140785676G>T	ENST00000370515.3	-	2	573	c.240C>A	c.(238-240)ctC>ctA	p.L80L		NM_032417.2|NM_145665.1	NP_115793.1|NP_663698.1			SPANX family, member D											breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	9	Acute lymphoblastic leukemia(192;7.65e-05)					CCTCCATTTGGAGGGGGTTGA	0.443000													105	132					1.62402e-62	4.2057e-62	0.003610	1	0
TBX6	6911	broad.mit.edu	37	16	30100304	30100304	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:30100304C>T	ENST00000553607.1	-	3	1274	c.581G>A	c.(580-582)cGt>cAt	p.R194H	TBX6_ENST00000395224.2_Missense_Mutation_p.R194H|TBX6_ENST00000279386.2_Missense_Mutation_p.R194H			O95947	TBX6_HUMAN	T-box 6	194					anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	9						GAGCTTGACACGATGGAAAGA	0.647000													44	122					0	0	0.002852	0	0
KRT79	338785	broad.mit.edu	37	12	53227940	53227940	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:53227940T>C	ENST00000330553.5	-	1	139	c.105A>G	c.(103-105)tcA>tcG	p.S35S		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	35	Head.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ACACCGTCACTGAGCTGAAGC	0.647000													18	42					0	0	0.001882	0	0
ZFHX4	79776	broad.mit.edu	37	8	77775784	77775784	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:77775784C>A	ENST00000521891.2	+	11	10282	c.9834C>A	c.(9832-9834)ctC>ctA	p.L3278L	ZFHX4_ENST00000050961.6_Silent_p.L3229L|ZFHX4_ENST00000518282.1_Silent_p.L3252L|ZFHX4_ENST00000455469.2_Silent_p.L3233L	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	3229						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CACCTCAGCTCCCTGGAACAG	0.517000										HNSCC(33;0.089)			35	100					2.20474e-14	4.71738e-14	0.003755	1	0
SHOX	6473	broad.mit.edu	37	X	601734	601734	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:601734G>T	ENST00000381578.1	+	5	1236	c.544_splice	c.e5-1	p.G182_splice	SHOX_ENST00000554971.1_Splice_Site_p.G182_splice|SHOX_ENST00000334060.3_Splice_Site_p.G182_splice|SHOX_ENST00000381575.1_Splice_Site_p.G182_splice	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	182					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTGGACACAGGCGTCATCTTG	0.602000													18	49					8.28177e-16	1.83056e-15	0.000958	1	0
PSG11	5680	broad.mit.edu	37	19	43529181	43529181	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:43529181G>T	ENST00000401740.1	-	2	195	c.92C>A	c.(91-93)cCt>cAt	p.P31H	PSG11_ENST00000403486.1_Intron|PSG11_ENST00000306322.7_Intron|PSG11_ENST00000320078.7_Missense_Mutation_p.P31H			Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	31					female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	26		Prostate(69;0.00682)				GGCAGTGGTAGGCAAGTTCCA	0.483000													50	153					4.01344e-20	9.4653e-20	0.003610	1	0
CDK5RAP2	55755	broad.mit.edu	37	9	123177356	123177356	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:123177356C>G	ENST00000349780.4	-	28	4438	c.4259G>C	c.(4258-4260)cGg>cCg	p.R1420P	CDK5RAP2_ENST00000360190.4_Missense_Mutation_p.R1420P|CDK5RAP2_ENST00000359309.3_Missense_Mutation_p.R1379P|CDK5RAP2_ENST00000360822.3_Missense_Mutation_p.R1388P	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1420					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding	p.R1420L(1)		breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						CAACTGTTTCCGTAGCTTCTC	0.408000													23	93					0	0	0.002780	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	A	G	rs141732548	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:14414855A>G	ENST00000507941.1	+	0	95																											GCCAATGGCCATGCAGAAGTA	0.448000													4	40					0	0	0.000248	0	0
TRO	7216	broad.mit.edu	37	X	54949662	54949662	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:54949662A>G	ENST00000173898.7	+	3	809	c.697A>G	c.(697-699)Acc>Gcc	p.T233A	TRO_ENST00000319167.8_Missense_Mutation_p.T233A|TRO_ENST00000420798.2_Intron|TRO_ENST00000399736.1_Intron|TRO_ENST00000375022.4_Missense_Mutation_p.T233A|TRO_ENST00000375041.2_Intron|TRO_ENST00000484031.1_Intron	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	233					embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						CCATACAGCTACCACCCAAGG	0.512000													23	11					0	0	0.002780	0	0
KCNIP1	30820	broad.mit.edu	37	5	170147332	170147332	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:170147332C>A	ENST00000328939.4	+	3	731	c.194C>A	c.(193-195)cCc>cAc	p.P65H	KCNIP1_ENST00000377360.4_Missense_Mutation_p.P74H|KCNIP1_ENST00000411494.1_Missense_Mutation_p.P76H|KCNIP1_ENST00000520740.1_Missense_Mutation_p.P37H|KCNIP1_ENST00000434108.1_Missense_Mutation_p.P65H|KCNIP1_ENST00000390656.4_Missense_Mutation_p.P65H	NM_001034837.1|NM_014592.2	NP_001030009.1|NP_055407.1	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1	76	EF-hand 1; degenerate.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			autonomic_ganglia(1)|large_intestine(7)|lung(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	18	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGGAGTGCCCCAGTGGTGTG	0.547000													9	30					2.17888e-05	3.71854e-05	0.000443	1	0
OR4S2	219431	broad.mit.edu	37	11	55419304	55419304	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55419304A>G	ENST00000312422.2	+	1	925	c.925A>G	c.(925-927)Aaa>Gaa	p.K309E		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				CTTGGAGGCTAAAGGGAAATA	0.363000													49	119					0	0	0.003610	0	0
OR56B1	387748	broad.mit.edu	37	11	5758078	5758078	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:5758078A>G	ENST00000317121.3	+	1	398	c.332A>G	c.(331-333)tAt>tGt	p.Y111C	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		GCTCAGATTTATGCCATTCAC	0.458000													9	32					0	0	0.000978	0	0
PTPRT	11122	broad.mit.edu	37	20	41306563	41306563	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:41306563C>A	ENST00000373198.3	-	7	1331	c.1096G>T	c.(1096-1098)Ggt>Tgt	p.G366C	PTPRT_ENST00000356100.2_Missense_Mutation_p.G366C|PTPRT_ENST00000373187.1_Missense_Mutation_p.G366C|PTPRT_ENST00000373201.1_Missense_Mutation_p.G366C|PTPRT_ENST00000373190.1_Missense_Mutation_p.G366C|PTPRT_ENST00000373184.1_Missense_Mutation_p.G366C|PTPRT_ENST00000373193.3_Missense_Mutation_p.G366C	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	366	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCCCCCTCACCTGGTCGTGTG	0.562000													32	38					2.85442e-18	6.53228e-18	0.002096	1	0
FER1L5	90342	broad.mit.edu	37	2	97370351	97370351	+	RNA	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:97370351C>A	ENST00000457909.1	+	0	5599							A0AVI2	FR1L5_HUMAN	fer-1-like 5 (C. elegans)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(9)|large_intestine(9)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	38						CTACAATAGACCATGAGTGGA	0.463000													31	83					1.74807e-11	3.49788e-11	0.002096	1	0
SNORD3A	780851	broad.mit.edu	37	17	19091382	19091382	+	RNA	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:19091382T>G	ENST00000365494.1	+	0	54																											gaagtttctctgaacgtgtag	0.502000													26	483					0	0	0.003610	0	0
CPA3	1359	broad.mit.edu	37	3	148596303	148596303	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:148596303C>A	ENST00000296046.3	+	4	397	c.345C>A	c.(343-345)agC>agA	p.S115R	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	115					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			GCAGGCACAGCTACGCAAAAT	0.313000													67	39					3.05417e-18	6.98146e-18	0.003610	1	0
ZBTB16	7704	broad.mit.edu	37	11	113934661	113934661	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:113934661C>G	ENST00000335953.4	+	2	1019	c.639C>G	c.(637-639)ctC>ctG	p.L213L	ZBTB16_ENST00000392996.2_Silent_p.L213L	NM_006006.4	NP_005997.2	Q05516	ZBT16_HUMAN	zinc finger and BTB domain containing 16	213					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(2)	6		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		GACAGTCTCTCCTGCAGGGAA	0.597000													15	33					0	0	0.002450	0	0
DNAH9	1770	broad.mit.edu	37	17	11522951	11522951	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:11522951G>C	ENST00000262442.3	+	6	1271	c.1203G>C	c.(1201-1203)ttG>ttC	p.L401F	DNAH9_ENST00000454412.2_Missense_Mutation_p.L401F|DNAH9_ENST00000579406.1_3'UTR	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	401	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAGACACTTTGAGCTTCTTCA	0.443000													45	103					0	0	0.002852	0	0
FN3K	64122	broad.mit.edu	37	17	80699208	80699208	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:80699208A>T	ENST00000300784.7	+	4	469	c.407A>T	c.(406-408)gAg>gTg	p.E136V		NM_022158.3	NP_071441.1	Q9H479	FN3K_HUMAN	fructosamine 3 kinase	136					fructoselysine metabolic process		fructosamine-3-kinase activity			central_nervous_system(1)|kidney(1)|lung(1)|urinary_tract(1)	4	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			GAGGGTGCTGAGCCTCAGTAT	0.552000													8	9					0	0	0.003080	0	0
NOL8	55035	broad.mit.edu	37	9	95076834	95076834	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:95076834T>C	ENST00000545558.1	-	7	2565	c.2073A>G	c.(2071-2073)atA>atG	p.I691M	NOL8_ENST00000542053.1_Missense_Mutation_p.I623M|NOL8_ENST00000535387.1_Missense_Mutation_p.I691M|NOL8_ENST00000358855.4_Missense_Mutation_p.I623M|NOL8_ENST00000442668.2_Missense_Mutation_p.I691M			Q76FK4	NOL8_HUMAN	nucleolar protein 8	691					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						TGTCAAAGCCTATGTTGTGAG	0.438000													7	52					0	0	0.003080	0	0
AIRE	326	broad.mit.edu	37	21	45708269	45708269	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:45708269A>T	ENST00000291582.5	+	5	707	c.580A>T	c.(580-582)Atg>Ttg	p.M194L		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	194	SAND.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		AGCTGTGGCCATGTCCTCCGG	0.622000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				37	71					0	0	0.001485	0	0
GTSE1	51512	broad.mit.edu	37	22	46704670	46704670	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:46704670C>A	ENST00000454366.1	+	4	804	c.592C>A	c.(592-594)Cgc>Agc	p.R198S		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	179					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		TGCCCAGGCCCGCCTCACCCG	0.677000													45	87					6.4771e-29	1.61887e-28	0.002522	1	0
CABIN1	23523	broad.mit.edu	37	22	24480531	24480531	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:24480531G>T	ENST00000398319.2	+	21	3295		c.e21-1		CABIN1_ENST00000263119.5_Splice_Site|CABIN1_ENST00000405822.2_Splice_Site	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1						cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TTTTTTTCAAGGTGGATCTTA	0.408000													31	96					2.08457e-15	4.55248e-15	0.002096	1	0
LTBP2	4053	broad.mit.edu	37	14	74969972	74969972	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:74969972T>A	ENST00000261978.4	-	33	5224	c.4838A>T	c.(4837-4839)gAc>gTc	p.D1613V	LTBP2_ENST00000556690.1_Missense_Mutation_p.D1569V	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1613	TB 4.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGCCTCGCCGTCCTGGCAGCA	0.637000													19	35					0	0	0.002780	0	0
TMEM171	134285	broad.mit.edu	37	5	72427521	72427521	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:72427521A>T	ENST00000454765.2	+	4	1412	c.939A>T	c.(937-939)acA>acT	p.T313T	TMEM171_ENST00000287773.5_Silent_p.T312T			Q8WVE6	TM171_HUMAN	transmembrane protein 171	313						integral to membrane		p.T313T(1)		endometrium(5)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|stomach(1)	15		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		CTGCAGCTACATTCTTGCCTC	0.378000													37	67					0	0	0.001706	0	0
CACNA1E	777	broad.mit.edu	37	1	181705563	181705563	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:181705563A>T	ENST00000526775.1	+	21	3523	c.3358A>T	c.(3358-3360)Acc>Tcc	p.T1120S	CACNA1E_ENST00000357570.5_Missense_Mutation_p.T1090S|CACNA1E_ENST00000358338.5_Missense_Mutation_p.T1071S|CACNA1E_ENST00000367573.2_Missense_Mutation_p.T1139S|CACNA1E_ENST00000360108.3_Missense_Mutation_p.T1120S|CACNA1E_ENST00000367570.1_Missense_Mutation_p.T1139S|CACNA1E_ENST00000367567.4_Missense_Mutation_p.T746S	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1139					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CTTCAGCACCACCAACCCGTA	0.577000													5	13					0	0	0.000602	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092986	151092986	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:151092986T>A	ENST00000370340.3	+	3	1117	c.850T>A	c.(850-852)Tat>Aat	p.Y284N	MAGEA4_ENST00000393921.1_Missense_Mutation_p.Y284N|MAGEA4_ENST00000276344.2_Missense_Mutation_p.Y284N|MAGEA4_ENST00000360243.2_Missense_Mutation_p.Y284N|MAGEA4_ENST00000370337.4_Missense_Mutation_p.Y284N|MAGEA4_ENST00000393920.1_Missense_Mutation_p.Y284N|MAGEA4_ENST00000370335.1_Missense_Mutation_p.Y284N			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	284	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TGAAACCAGCTATGTGAAAGT	0.552000													85	59					0	0	0.003610	0	0
RPH3A	22895	broad.mit.edu	37	12	113321158	113321158	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:113321158C>T	ENST00000389385.4	+	16	1884	c.1387C>T	c.(1387-1389)Ctc>Ttc	p.L463F	RPH3A_ENST00000415485.3_Missense_Mutation_p.L463F|RPH3A_ENST00000447659.2_Missense_Mutation_p.L414F|RPH3A_ENST00000548866.1_Missense_Mutation_p.L414F|RPH3A_ENST00000549913.2_3'UTR|RPH3A_ENST00000551052.1_Missense_Mutation_p.L459F|RPH3A_ENST00000420983.2_Missense_Mutation_p.L463F|RPH3A_ENST00000543106.2_Missense_Mutation_p.L463F	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	463	C2 1.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GAATGAGACCCTCGTGTATCA	0.562000													10	23					0	0	0.000443	0	0
KANK4	163782	broad.mit.edu	37	1	62728768	62728768	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:62728768C>T	ENST00000371153.4	-	7	2913	c.2535G>A	c.(2533-2535)gaG>gaA	p.E845E	KANK4_ENST00000354381.3_Silent_p.E217E|KANK4_ENST00000371150.1_Silent_p.E201E|KANK4_ENST00000317477.4_5'UTR	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	845										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						TCTGACCTGTCTCCAGCAGCA	0.458000													10	10					0	0	0.000443	0	0
ME2	4200	broad.mit.edu	37	18	48439273	48439273	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:48439273G>T	ENST00000321341.5	+	4	617	c.345G>T	c.(343-345)acG>acT	p.T115T	ME2_ENST00000382927.3_Silent_p.T115T	NM_002396.4	NP_002387.1	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	115					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(3)	23		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	ATACACCGACGGTTGGTCTTG	0.323000													66	54					1.1794e-34	3.00389e-34	0.003610	1	0
ZFP42	132625	broad.mit.edu	37	4	188924241	188924241	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:188924241T>A	ENST00000326866.4	+	4	688	c.280T>A	c.(280-282)Tcc>Acc	p.S94T	ZFP42_ENST00000509524.1_Missense_Mutation_p.S94T	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	94					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		ACTTTTTGAGTCCTTGGAATA	0.428000													34	58					0	0	0.002445	0	0
OR4C15	81309	broad.mit.edu	37	11	55322574	55322574	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55322574C>T	ENST00000314644.2	+	1	792	c.792C>T	c.(790-792)ttC>ttT	p.F264F		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TCATAAACTTCTCCTTGTTGC	0.483000										HNSCC(20;0.049)			28	89					0	0	0.001271	0	0
BTNL8	79908	broad.mit.edu	37	5	180374703	180374703	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:180374703C>T	ENST00000231229.4	+	4	1099	c.865C>T	c.(865-867)Cca>Tca	p.P289S	BTNL8_ENST00000511704.1_Intron|BTNL8_ENST00000508408.1_Missense_Mutation_p.P289S|BTNL8_ENST00000400707.3_Intron|BTNL8_ENST00000340184.4_Intron|BTNL8_ENST00000505126.1_Intron|BTNL8_ENST00000533815.2_Intron	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	146	B30.2/SPRY.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTCCCACATCCAGCTGCTTC	0.488000													95	230					0	0	0.003610	0	0
STX7	8417	broad.mit.edu	37	6	132824653	132824653	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:132824653C>A	ENST00000367941.2	-	2	130	c.17G>T	c.(16-18)gGa>gTa	p.G6V	STX7_ENST00000448348.3_5'UTR|STX7_ENST00000367937.4_Missense_Mutation_p.G6V	NM_003569.2	NP_003560.2	O15400	STX7_HUMAN	syntaxin 7	6					intracellular protein transport|post-Golgi vesicle-mediated transport	early endosome membrane|integral to membrane	SNAP receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|liver(1)|lung(5)	19	Breast(56;0.0615)			OV - Ovarian serous cystadenocarcinoma(155;0.00532)|GBM - Glioblastoma multiforme(226;0.0114)		ACCACCAACTCCTGGAGTGTA	0.413000													31	72					4.11147e-13	8.45464e-13	0.003755	1	0
RUNDC1	146923	broad.mit.edu	37	17	41133041	41133041	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:41133041G>C	ENST00000361677.1	+	1	460	c.448G>C	c.(448-450)Gag>Cag	p.E150Q		NM_173079.2	NP_775102.2	Q96C34	RUND1_HUMAN	RUN domain containing 1	150										breast(1)|large_intestine(2)|lung(4)|prostate(1)	8		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		CGCCAGCGATGAGGGCGATGG	0.697000													4	6					0	0	0.000248	0	0
PEG3	5178	broad.mit.edu	37	19	57335011	57335011	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:57335011A>T	ENST00000326441.9	-	5	794	c.431T>A	c.(430-432)aTg>aAg	p.M144K	ZIM2_ENST00000601070.1_Missense_Mutation_p.M18K|ZIM2_ENST00000599935.1_Missense_Mutation_p.M18K|ZIM2_ENST00000391708.3_Missense_Mutation_p.M18K|PEG3_ENST00000598410.1_Missense_Mutation_p.M18K|ZIM2_ENST00000593931.1_Missense_Mutation_p.M18K|ZIM2_ENST00000593711.1_Missense_Mutation_p.M18K|PEG3_ENST00000423103.2_Missense_Mutation_p.M144K|ZIM2_ENST00000221722.5_Missense_Mutation_p.M18K|PEG3_ENST00000593695.1_Missense_Mutation_p.M18K	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	144					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTTCCGGGTCATGTCGTCGTC	0.552000													29	62					0	0	0.003755	0	0
LITAF	9516	broad.mit.edu	37	16	11647435	11647435	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:11647435C>A	ENST00000571688.1	-	3	561	c.331G>T	c.(331-333)Gcc>Tcc	p.A111S	LITAF_ENST00000413364.2_Missense_Mutation_p.A111S|LITAF_ENST00000381810.3_Missense_Mutation_p.A111S|LITAF_ENST00000339430.5_Missense_Mutation_p.A111S|LITAF_ENST00000571459.1_Intron|LITAF_ENST00000570904.1_Missense_Mutation_p.A111S|LITAF_ENST00000576036.1_Missense_Mutation_p.A111S|LITAF_ENST00000574763.1_Missense_Mutation_p.A111S|LITAF_ENST00000572255.1_Missense_Mutation_p.A18S|LITAF_ENST00000571976.1_Missense_Mutation_p.A111S	NM_001136472.1	NP_001129944.1	Q99732	LITAF_HUMAN	lipopolysaccharide-induced TNF factor	111					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|lysosomal membrane	signal transducer activity|WW domain binding			endometrium(1)|large_intestine(1)|liver(1)|lung(3)|skin(1)	7						AGAGCACCGGCGTTATAGGAC	0.592000													13	39					9.31168e-06	1.61108e-05	0.001855	1	0
PLAA	9373	broad.mit.edu	37	9	26905641	26905641	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:26905641A>G	ENST00000397292.3	-	14	2673	c.2256T>C	c.(2254-2256)ctT>ctC	p.L752L		NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	752	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		CATCACTGATAAGTGTTCCAA	0.373000													18	53					0	0	0.004990	0	0
DNAH5	1767	broad.mit.edu	37	5	13788868	13788868	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:13788868G>T	ENST00000265104.4	-	51	8708	c.8604C>A	c.(8602-8604)gaC>gaA	p.D2868E		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2868					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CAAAATATGTGTCAATTCCAC	0.413000									Kartagener syndrome				26	83					2.44723e-14	5.21401e-14	0.004656	1	0
OPA3	80207	broad.mit.edu	37	19	46056875	46056875	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:46056875T>A	ENST00000263275.4	-	2	491	c.437A>T	c.(436-438)cAg>cTg	p.Q146L	OPA3_ENST00000323060.3_Intron|OPA3_ENST00000544371.1_Missense_Mutation_p.Q93L	NM_025136.3	NP_079412.1	Q9H6K4	OPA3_HUMAN	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)	146					response to stimulus|visual perception	mitochondrion				cervix(1)|large_intestine(1)|lung(2)	4		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		CAGGGCGCCCTGTGGCGGCGC	0.716000													13	39					0	0	0.001368	0	0
DNAH5	1767	broad.mit.edu	37	5	13864714	13864714	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:13864714C>A	ENST00000265104.4	-	28	4492	c.4388G>T	c.(4387-4389)tGg>tTg	p.W1463L	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1463	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AAAAGCCTGCCAGTCCTTCAA	0.507000									Kartagener syndrome				23	51					9.95505e-16	2.18597e-15	0.002299	1	0
PDGFRA	5156	broad.mit.edu	37	4	55139799	55139799	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:55139799G>C	ENST00000257290.5	+	10	1791	c.1460G>C	c.(1459-1461)cGt>cCt	p.R487P	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	487	Ig-like C2-type 5.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GTGGAGGGCCGTGTGACTTTC	0.522000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			28	78					0	0	0.005443	0	0
OR51Q1	390061	broad.mit.edu	37	11	5443437	5443437	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:5443437C>A	ENST00000300778.4	+	1	97	c.7C>A	c.(7-9)Cag>Aag	p.Q3K	HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	3					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGTCATGTCCCAGGTGACTAA	0.448000													36	77					7.11191e-15	1.5348e-14	0.002836	1	0
MMP20	9313	broad.mit.edu	37	11	102477375	102477375	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:102477375G>C	ENST00000260228.2	-	6	856	c.844C>G	c.(844-846)Ctg>Gtg	p.L282V	MMP20_ENST00000544938.1_5'UTR	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	282					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		GCATGGGGCAGAGTGGGCTTC	0.522000													19	47					0	0	0.000958	0	0
RHAG	6005	broad.mit.edu	37	6	49578777	49578777	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:49578777G>T	ENST00000371175.4	-	7	1053	c.1027C>A	c.(1027-1029)Ctt>Att	p.L343I	RHAG_ENST00000229810.7_Intron	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	343					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					ATGCCTGCAAGGCCTCCCACT	0.473000													50	48					2.9001e-28	7.23943e-28	0.003610	1	0
CCDC14	64770	broad.mit.edu	37	3	123633847	123633847	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:123633847G>T	ENST00000485727.1	-	9	6633	c.2041C>A	c.(2041-2043)Cat>Aat	p.H681N	CCDC14_ENST00000433542.2_Missense_Mutation_p.H840N|CCDC14_ENST00000310351.4_Missense_Mutation_p.H721N|CCDC14_ENST00000483247.1_5'UTR|CCDC14_ENST00000488653.2_Missense_Mutation_p.H881N|CCDC14_ENST00000489746.1_Missense_Mutation_p.H681N			Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	881						centrosome				NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)	21		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		GATGGGCCATGACATGCAGTT	0.458000													18	89					3.41278e-10	6.65642e-10	0.004990	1	0
C10orf120	399814	broad.mit.edu	37	10	124457725	124457725	+	Missense_Mutation	SNP	C	C	T	rs148798284		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:124457725C>T	ENST00000329446.4	-	3	563	c.532G>A	c.(532-534)Gga>Aga	p.G178R		NM_001010912.1	NP_001010912.1	Q5SQS8	CJ120_HUMAN	chromosome 10 open reading frame 120	178										endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|skin(2)|stomach(1)|urinary_tract(1)	21		all_neural(114;0.169)|Glioma(114;0.222)				TGATGATTTCCCAGAGCCCGA	0.502000													35	85					0	0	0.003271	0	0
RGS3	5998	broad.mit.edu	37	9	116353656	116353656	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:116353656G>T	ENST00000374140.2	+	22	3268	c.3059G>T	c.(3058-3060)cGg>cTg	p.R1020L	RGS3_ENST00000342620.5_Intron|RGS3_ENST00000374134.3_Missense_Mutation_p.R341L|RGS3_ENST00000350696.5_Missense_Mutation_p.R1020L|RGS3_ENST00000343817.5_Missense_Mutation_p.R739L|RGS3_ENST00000462143.1_Missense_Mutation_p.R341L|RGS3_ENST00000394646.3_Missense_Mutation_p.R413L	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	1020					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						GAAGCCTCCCGGAAGAGAAAG	0.587000													24	63					2.44723e-14	5.21401e-14	0.004656	1	0
NLRP4	147945	broad.mit.edu	37	19	56382227	56382227	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:56382227G>A	ENST00000301295.6	+	7	2811	c.2389G>A	c.(2389-2391)Gaa>Aaa	p.E797K	NLRP4_ENST00000587891.1_Missense_Mutation_p.E722K|NLRP4_ENST00000346986.5_Missense_Mutation_p.E741K	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	797							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GCAGTGCTGCGAATACATCTC	0.512000													25	51					0	0	0.001061	0	0
TNKS	8658	broad.mit.edu	37	8	9609323	9609323	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:9609323G>T	ENST00000310430.6	+	19	3063	c.3037G>T	c.(3037-3039)Ggc>Tgc	p.G1013C	TNKS_ENST00000518281.1_Missense_Mutation_p.G776C	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	1013					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		TGCAGGGGATGGCGCCGCGGG	0.522000													39	101					5.44703e-19	1.27118e-18	0.002222	1	0
PRIMA1	145270	broad.mit.edu	37	14	94187840	94187840	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:94187840T>G	ENST00000393140.1	-	5	514	c.412A>C	c.(412-414)Agt>Cgt	p.S138R	PRIMA1_ENST00000316227.3_3'UTR|PRIMA1_ENST00000393143.1_Missense_Mutation_p.S138R	NM_178013.3	NP_821092.1	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1	138					neurotransmitter catabolic process	cell junction|integral to membrane|synapse				endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		TGCGAAGCACTCATGGGATAC	0.587000													14	36					0	0	0.003163	0	0
FBN2	2201	broad.mit.edu	37	5	127671152	127671152	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:127671152C>T	ENST00000508053.1	-	35	4816	c.3842G>A	c.(3841-3843)tGt>tAt	p.C1281Y	FBN2_ENST00000508989.1_Missense_Mutation_p.C1248Y|FBN2_ENST00000262464.4_Missense_Mutation_p.C1281Y|FBN2_ENST00000507835.1_Missense_Mutation_p.C131Y			P35556	FBN2_HUMAN	fibrillin 2	1281	EGF-like 19; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TATACCTGCACACGATCTCCC	0.433000													26	98					0	0	0.003954	0	0
MUC16	94025	broad.mit.edu	37	19	9059658	9059658	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9059658G>C	ENST00000397910.4	-	3	27991	c.27788C>G	c.(27787-27789)aCa>aGa	p.T9263R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9265	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGAACATTTGTATCTCCTGT	0.473000													29	90					0	0	0.001061	0	0
CRLF2	64109	broad.mit.edu	37	X	1317518	1317518	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:1317518A>G	ENST00000381567.3	-	5	546	c.547T>C	c.(547-549)Ttc>Ctc	p.F183L	CRLF2_ENST00000467626.1_Intron	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	183	Fibronectin type-III.					extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CTGACCCAGAAAGAGTAACAC	0.507000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								26	54					0	0	0.001061	0	0
C2orf53	339779	broad.mit.edu	37	2	27360306	27360306	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:27360306A>T	ENST00000335524.3	-	3	1417	c.892T>A	c.(892-894)Ttc>Atc	p.F298I		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	298										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGGAGGCCGAAGCCGATGCCT	0.657000													15	36					0	0	0.004990	0	0
OR5T2	219464	broad.mit.edu	37	11	55999944	55999944	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55999944A>T	ENST00000313264.4	-	1	793	c.718T>A	c.(718-720)Tac>Aac	p.Y240N		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					CCCACAAAGTAGAAGAGTAGA	0.438000													35	100					0	0	0.003271	0	0
NAV2	89797	broad.mit.edu	37	11	20066746	20066746	+	Silent	SNP	C	C	T	rs140697093	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:20066746C>T	ENST00000396085.1	+	14	3793	c.3432C>T	c.(3430-3432)agC>agT	p.S1144S	NAV2_ENST00000540292.1_Silent_p.S1098S|NAV2_ENST00000533917.1_Silent_p.S230S|NAV2-AS2_ENST00000533767.1_RNA|NAV2_ENST00000311043.8_Silent_p.S230S|NAV2_ENST00000396087.3_Silent_p.S1167S|NAV2_ENST00000360655.4_Silent_p.S1080S|NAV2_ENST00000349880.4_Silent_p.S1144S|NAV2_ENST00000527559.2_Silent_p.S1096S	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1167						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						CTGTCACCAGCAGGTCAGCCA	0.577000													19	79					0	0	0.002299	0	0
NRXN1	9378	broad.mit.edu	37	2	50779857	50779857	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:50779857T>C	ENST00000404971.1	-	10	3086	c.1747A>G	c.(1747-1749)Att>Gtt	p.I583V	NRXN1_ENST00000405472.3_Missense_Mutation_p.I535V|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000402717.3_Missense_Mutation_p.I535V|NRXN1_ENST00000401669.2_Missense_Mutation_p.I543V|NRXN1_ENST00000406316.2_Missense_Mutation_p.I543V|NRXN1_ENST00000406859.3_Missense_Mutation_p.I543V	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	543	Laminin G-like 3.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AGCATCTCAATAGCAAAGAAG	0.443000													27	79					0	0	0.005443	0	0
ABCA13	154664	broad.mit.edu	37	7	48619833	48619833	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:48619833C>A	ENST00000435803.1	+	56	14392	c.14368C>A	c.(14368-14370)Ctg>Atg	p.L4790M	ABCA13_ENST00000544596.1_Missense_Mutation_p.L520M	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4790	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CGCCGTGGACCTGTCTTCTGC	0.522000													4	8					2.7689e-08	5.15508e-08	0.001984	1	0
MFHAS1	9258	broad.mit.edu	37	8	8750112	8750112	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:8750112G>C	ENST00000276282.6	-	1	1043	c.457C>G	c.(457-459)Cag>Gag	p.Q153E		NM_004225.2	NP_004216.2	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified sequence 1	153										endometrium(1)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|stomach(1)	21		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		GCGCCCAGCTGGGCGGGCAGG	0.692000													6	13					0	0	0.001168	0	0
TECTA	7007	broad.mit.edu	37	11	120998532	120998532	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:120998532G>T	ENST00000392793.1	+	9	2117	c.1846G>T	c.(1846-1848)Gac>Tac	p.D616Y	TECTA_ENST00000264037.2_Missense_Mutation_p.D616Y			O75443	TECTA_HUMAN	tectorin alpha	616	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CACATGCTCCGACCTGACGGC	0.642000													26	70					1.5548e-18	3.57444e-18	0.005443	1	0
TSHZ3	57616	broad.mit.edu	37	19	31769884	31769884	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:31769884T>A	ENST00000240587.4	-	2	1142	c.815A>T	c.(814-816)cAg>cTg	p.Q272L		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	272					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					CAGCACCTTCTGGGCGTCTTC	0.512000													44	148					0	0	0.002852	0	0
C17orf47	284083	broad.mit.edu	37	17	56619276	56619276	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:56619276C>A	ENST00000321691.3	-	2	1794	c.1613G>T	c.(1612-1614)tGc>tTc	p.C538F	RP11-112H10.4_ENST00000580589.1_RNA|RP11-112H10.4_ENST00000578022.1_RNA|RP11-112H10.4_ENST00000580769.1_RNA	NM_001038704.2	NP_001033793.2	Q8NEP4	CQ047_HUMAN	chromosome 17 open reading frame 47	538										NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	24	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGGGAAAAGCACAGACCTTT	0.493000													46	102					2.00842e-17	4.5393e-17	0.002522	1	0
KIFAP3	22920	broad.mit.edu	37	1	169941740	169941740	+	Splice_Site	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:169941740C>G	ENST00000367765.1	-	17	3279		c.e17-1		KIFAP3_ENST00000367767.1_Splice_Site|KIFAP3_ENST00000540905.1_Splice_Site|KIFAP3_ENST00000361580.2_Splice_Site|KIFAP3_ENST00000538366.1_Splice_Site	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3						blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCTGGAGCCTCTGAATAAAAA	0.279000													7	18					0	0	0.003080	0	0
ABL2	27	broad.mit.edu	37	1	179077050	179077050	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:179077050C>A	ENST00000502732.1	-	12	3555	c.3352G>T	c.(3352-3354)Gac>Tac	p.D1118Y	ABL2_ENST00000367623.4_Missense_Mutation_p.D1097Y|ABL2_ENST00000344730.3_Missense_Mutation_p.D1000Y|ABL2_ENST00000511413.1_Missense_Mutation_p.D1015Y|ABL2_ENST00000507173.1_Missense_Mutation_p.D994Y|ABL2_ENST00000504405.1_Missense_Mutation_p.D979Y|ABL2_ENST00000512653.1_Missense_Mutation_p.D1103Y|ABL2_ENST00000408940.3_Missense_Mutation_p.D1082Y	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	1118	F-actin-binding (By similarity).				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GAGCAGTAGTCAAGCAGCTGG	0.552000			T	ETV6	AML								15	45					7.93312e-07	1.41401e-06	0.002450	1	0
ACACB	32	broad.mit.edu	37	12	109650676	109650676	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:109650676G>C	ENST00000338432.7	+	22	3404	c.3285G>C	c.(3283-3285)ctG>ctC	p.L1095L	ACACB_ENST00000377848.3_Silent_p.L1095L|ACACB_ENST00000377854.5_Silent_p.L1095L			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1095					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CAGCCACCCTGCAGCGGAAGG	0.542000													45	114					0	0	0.003610	0	0
TNN	63923	broad.mit.edu	37	1	175067479	175067479	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:175067479C>G	ENST00000239462.4	+	9	1980	c.1867C>G	c.(1867-1869)Ccc>Gcc	p.P623A		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	623	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TATTGACAGCCCCAAAAACCT	0.507000													40	122					0	0	0.004878	0	0
HDC	3067	broad.mit.edu	37	15	50534984	50534984	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:50534984C>A	ENST00000267845.3	-	12	1864	c.1462G>T	c.(1462-1464)Ggg>Tgg	p.G488W	HDC_ENST00000543581.1_Missense_Mutation_p.G455W	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	488					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	ATGAGGTTCCCAACCCGAGGG	0.567000													16	30					1.5739e-10	3.08478e-10	0.004007	1	0
ESX1	80712	broad.mit.edu	37	X	103495025	103495025	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:103495025C>A	ENST00000372588.4	-	4	1188	c.1105G>T	c.(1105-1107)Ggg>Tgg	p.G369W		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	369	15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						ATGGGCGGCCCGGGTGGCAGA	0.701000													11	11					0.000673444	0.00110787	0.000673	1	0
EBF2	64641	broad.mit.edu	37	8	25715905	25715905	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:25715905G>T	ENST00000520164.1	-	14	1995	c.1458C>A	c.(1456-1458)ccC>ccA	p.P486P	EBF2_ENST00000535548.1_Silent_p.P217P|EBF2_ENST00000408929.3_Silent_p.P338P	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	486	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		AGTTGGCCATGGGGACATTGC	0.522000													32	59					2.85442e-18	6.53228e-18	0.002096	1	0
DPYD	1806	broad.mit.edu	37	1	97771816	97771816	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:97771816C>A	ENST00000370192.3	-	17	2196	c.2096G>T	c.(2095-2097)aGg>aTg	p.R699M	DPYD-AS1_ENST00000422980.1_RNA	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	699					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AACAGCTTGCCTAACCCAGCG	0.423000													41	157					6.45866e-13	1.32271e-12	0.001951	1	0
TAS2R38	5726	broad.mit.edu	37	7	141673292	141673292	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:141673292G>T	ENST00000547270.1	-	1	281	c.198C>A	c.(196-198)ttC>ttA	p.F66L		NM_176817.4	NP_789787.4	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	66					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			NS(2)|breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)|stomach(1)	21	Melanoma(164;0.0171)					GTCCATGCAGGAAAAGCCGGC	0.493000													37	85					2.42023e-17	5.45776e-17	0.003271	1	0
AASDH	132949	broad.mit.edu	37	4	57215852	57215852	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:57215852A>T	ENST00000205214.6	-	11	2245	c.2065T>A	c.(2065-2067)Tct>Act	p.S689T	AASDH_ENST00000502617.1_Missense_Mutation_p.S689T|AASDH_ENST00000602986.1_Missense_Mutation_p.S536T|AASDH_ENST00000451613.1_Missense_Mutation_p.S689T|AASDH_ENST00000513376.1_Missense_Mutation_p.S589T|AASDH_ENST00000434343.2_Missense_Mutation_p.S204T	NM_181806.2	NP_861522.2	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	689					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	40	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				GAATTCAGAGACAAAATTTGA	0.393000													24	79					0	0	0.002299	0	0
PDCD4	27250	broad.mit.edu	37	10	112647635	112647635	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:112647635A>T	ENST00000393104.2	+	7	1095	c.735A>T	c.(733-735)agA>agT	p.R245S	PDCD4_ENST00000280154.7_Missense_Mutation_p.R256S|PDCD4_ENST00000481353.1_3'UTR	NM_145341.3	NP_663314.1	Q53EL6	PDCD4_HUMAN	programmed cell death 4 (neoplastic transformation inhibitor)	256	MI 1.				apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	13		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)		ATACTCCTAGAGCACCACAGG	0.353000													14	28					0	0	0.002450	0	0
HSD3B2	3284	broad.mit.edu	37	1	119958051	119958051	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:119958051G>T	ENST00000543831.1	+	2	258	c.9G>T	c.(7-9)tgG>tgT	p.W3C	HSD3B2_ENST00000471656.1_3'UTR|HSD3B2_ENST00000369416.3_Missense_Mutation_p.W3C	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	3					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CGATGGGCTGGAGCTGCCTTG	0.552000													24	71					7.87624e-14	1.65525e-13	0.002780	1	0
PCMT1	5110	broad.mit.edu	37	6	150094294	150094294	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:150094294G>T	ENST00000464889.1	+	3	639	c.355G>T	c.(355-357)Gct>Tct	p.A119S	PCMT1_ENST00000544496.1_Missense_Mutation_p.A26S|PCMT1_ENST00000367380.5_Missense_Mutation_p.A61S|PCMT1_ENST00000367384.2_Missense_Mutation_p.A119S|PCMT1_ENST00000367378.1_Missense_Mutation_p.A119S					protein-L-isoaspartate (D-aspartate) O-methyltransferase											kidney(1)|large_intestine(2)|lung(4)|ovary(1)	8		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.221)	OV - Ovarian serous cystadenocarcinoma(155;5.63e-13)|GBM - Glioblastoma multiforme(68;0.207)		AACAATCAGTGCTCCACACAT	0.303000													20	45					6.21321e-17	1.39173e-16	0.002780	1	0
MCF2L2	23101	broad.mit.edu	37	3	182924003	182924003	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:182924003C>A	ENST00000328913.3	-	24	3010		c.e24-1		MCF2L2_ENST00000473233.1_Splice_Site|MCF2L2_ENST00000468976.1_Splice_Site	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GTGTCATCAGCTATTATAAAG	0.408000													25	133					4.26978e-12	8.57802e-12	0.003330	1	0
TBL1Y	90665	broad.mit.edu	37	Y	6958154	6958154	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:6958154C>A	ENST00000383032.1	+	18	2118	c.1471C>A	c.(1471-1473)Caa>Aaa	p.Q491K	TBL1Y_ENST00000355162.2_Missense_Mutation_p.Q491K|TBL1Y_ENST00000346432.3_Missense_Mutation_p.Q491K	NM_033284.1	NP_150600.1	Q9BQ87	TBL1Y_HUMAN	transducin (beta)-like 1, Y-linked	491					transcription, DNA-dependent					kidney(1)|large_intestine(4)|lung(2)|skin(1)	8						CCACAGCTACCAAGGCACTGG	0.532000													11	11					7.03913e-09	1.32778e-08	0.001368	1	0
DNAH8	1769	broad.mit.edu	37	6	38885916	38885916	+	Splice_Site	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:38885916G>A	ENST00000359357.3	+	68	10127	c.9873_splice	c.e68+1	p.K3291_splice	DNAH8_ENST00000449981.2_Splice_Site_p.K3508_splice|DNAH8_ENST00000441566.1_Splice_Site_p.K3255_splice					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGCCTCTGAAGGTAAAAGTTT	0.373000													13	48					0	0	0.001368	0	0
DNM1P46	196968	broad.mit.edu	37	15	100332882	100332882	+	RNA	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:100332882C>A	ENST00000341853.1	-	0	1309					NR_003260.1																						GAGCCTGGTCCAGGAGCCCCA	0.622000													13	34					9.31168e-06	1.61108e-05	0.001855	1	0
CXADRP3	440224	broad.mit.edu	37	18	14478763	14478763	+	RNA	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:14478763G>T	ENST00000581457.1	-	0	1145					NR_024076.1																						TAATGGAAGTGAACCTTCTTT	0.353000													10	40					1.58986e-06	2.799e-06	0.000673	1	0
CACNA1E	777	broad.mit.edu	37	1	181754552	181754552	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:181754552C>G	ENST00000526775.1	+	41	5785	c.5620C>G	c.(5620-5622)Cag>Gag	p.Q1874E	CACNA1E_ENST00000357570.5_Missense_Mutation_p.Q1844E|CACNA1E_ENST00000358338.5_Missense_Mutation_p.Q1825E|CACNA1E_ENST00000367573.2_Missense_Mutation_p.Q1893E|CACNA1E_ENST00000360108.3_Missense_Mutation_p.Q1874E|CACNA1E_ENST00000367570.1_Missense_Mutation_p.Q1893E|CACNA1E_ENST00000367567.4_Missense_Mutation_p.Q1500E	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1893					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.Q1893E(1)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GCTGGAGGAACAGGTGAAAGT	0.537000													6	19					0	0	0.001168	0	0
PRR14L	253143	broad.mit.edu	37	22	32072838	32072838	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:32072838T>A	ENST00000397493.2	-	9	6538	c.6346A>T	c.(6346-6348)Agg>Tgg	p.R2116W				Q5THK1	PR14L_HUMAN	proline rich 14-like	0										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(5)|skin(1)|urinary_tract(2)	14						AGCAGCCTCCTCCAATATGGA	0.667000													5	14					0	0	0.000602	0	0
OR8H3	390152	broad.mit.edu	37	11	55890065	55890065	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55890065A>G	ENST00000313472.3	+	1	217	c.217A>G	c.(217-219)Agt>Ggt	p.S73G		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					TATTGACCTCAGTTACTCAAC	0.443000													85	224					0	0	0.003610	0	0
SGK223	157285	broad.mit.edu	37	8	8185684	8185684	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:8185684G>A	ENST00000520004.1	-	5	2872	c.2608C>T	c.(2608-2610)Cac>Tac	p.H870Y	SGK223_ENST00000330777.4_Missense_Mutation_p.H870Y			Q86YV5	SG223_HUMAN		870							ATP binding|non-membrane spanning protein tyrosine kinase activity										ACAGGATGGTGGCGGTTCCCG	0.592000													91	239					0	0	0.003610	0	0
ASPH	444	broad.mit.edu	37	8	62566183	62566183	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:62566183G>A	ENST00000541428.1	-	4	432	c.272C>T	c.(271-273)cCg>cTg	p.P91L	ASPH_ENST00000522835.1_Missense_Mutation_p.P106L|ASPH_ENST00000356457.5_Missense_Mutation_p.P120L|ASPH_ENST00000379454.4_Missense_Mutation_p.P120L|ASPH_ENST00000517847.2_Missense_Mutation_p.P106L|ASPH_ENST00000445642.3_Missense_Mutation_p.P106L|ASPH_ENST00000517903.1_Missense_Mutation_p.P106L|ASPH_ENST00000518068.1_Missense_Mutation_p.P120L	NM_001164750.1	NP_001158222.1	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase	120					muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			breast(1)|cervix(1)|endometrium(5)|large_intestine(5)|lung(16)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	CTCTTCTGGCGGGACTGCTGG	0.502000													7	30					0	0	0.003080	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887082	9887082	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:9887082C>G	ENST00000306084.6	+	2	805	c.606C>G	c.(604-606)atC>atG	p.I202M	TXNDC2_ENST00000357775.4_Missense_Mutation_p.I135M|TXNDC2_ENST00000536353.2_Intron	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	202	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						AAGAAGCCATCCAGCCCAAAG	0.577000													55	534					0	0	0.003610	0	0
RP1L1	94137	broad.mit.edu	37	8	10470038	10470038	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:10470038T>A	ENST00000382483.3	-	4	1793	c.1570A>T	c.(1570-1572)Agg>Tgg	p.R524W		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	524					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTCCGGGCCCTCGGTGTCAGG	0.697000													22	67					0	0	0.002780	0	0
DNAH10	196385	broad.mit.edu	37	12	124383262	124383262	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:124383262G>T	ENST00000409039.3	+	55	9212	c.9187G>T	c.(9187-9189)Gag>Tag	p.E3063*		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3063	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CCAGCTGGACGAGCTGAACCA	0.617000													3	12					6.4e-05	0.000107782	0.004672	1	0
CACNA1I	8911	broad.mit.edu	37	22	40042659	40042659	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:40042659T>C	ENST00000336649.4	+	10	1235	c.1235T>C	c.(1234-1236)aTg>aCg	p.M412T	CACNA1I_ENST00000400164.3_Missense_Mutation_p.M412T|CACNA1I_ENST00000407673.1_Missense_Mutation_p.M412T|CACNA1I_ENST00000401624.1_Missense_Mutation_p.M412T|CACNA1I_ENST00000404898.1_Missense_Mutation_p.M412T|CACNA1I_ENST00000402142.3_Missense_Mutation_p.M412T			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	412					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CACCGGCTGATGCTGGAGCAG	0.607000													5	7					0	0	0.000602	0	0
SAMSN1	64092	broad.mit.edu	37	21	15872886	15872886	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:15872886C>A	ENST00000285670.2	-	7	1110	c.936G>T	c.(934-936)aaG>aaT	p.K312N	SAMSN1_ENST00000400564.1_Missense_Mutation_p.K76N|SAMSN1_ENST00000463807.1_5'UTR|SAMSN1_ENST00000400566.1_Missense_Mutation_p.K244N	NM_001256370.1	NP_001243299.1	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization signals 1	244					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	24				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		CCTGCAGAGTCTTGGATTTTT	0.433000													10	57					2.80697e-09	5.32476e-09	0.000978	1	0
ENKUR	219670	broad.mit.edu	37	10	25279433	25279433	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:25279433T>C	ENST00000331161.4	-	4	772	c.553A>G	c.(553-555)Atg>Gtg	p.M185V	ENKUR_ENST00000376363.1_Missense_Mutation_p.M185V	NM_145010.3	NP_659447.1	Q8TC29	ENKUR_HUMAN	enkurin, TRPC channel interacting protein	185	IQ.					cilium|flagellum	calmodulin binding|SH3 domain binding			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						AGCCTTTTCATAGCTGCTTTC	0.408000													22	43					0	0	0.001523	0	0
AMPD2	271	broad.mit.edu	37	1	110170415	110170415	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:110170415C>A	ENST00000256578.3	+	9	1492	c.1132C>A	c.(1132-1134)Cgg>Agg	p.R378R	AMPD2_ENST00000358729.4_Silent_p.R303R|AMPD2_ENST00000393688.3_Silent_p.R259R|AMPD2_ENST00000342115.4_Silent_p.R297R|AMPD2_ENST00000528667.1_Silent_p.R378R|AMPD2_ENST00000528454.1_Silent_p.R260R|AMPD2_ENST00000526301.1_3'UTR	NM_004037.7	NP_004028.3	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2	378					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			breast(1)|large_intestine(3)|ovary(2)|skin(1)	7		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		CTGCTACCGCCGGCTGCAGTA	0.557000													13	41					1.36491e-13	2.85055e-13	0.001855	1	0
AFMID	125061	broad.mit.edu	37	17	76200969	76200969	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:76200969A>G	ENST00000409257.5	+	6	509	c.455A>G	c.(454-456)tAt>tGt	p.Y152C	AFMID_ENST00000327898.5_Missense_Mutation_p.Y152C|AFMID_ENST00000589664.1_3'UTR|AFMID_ENST00000588800.1_Intron|AFMID_ENST00000591952.1_Intron	NM_001010982.4|NM_001145526.2	NP_001010982.2|NP_001138998.1	Q63HM1	AFMID_HUMAN	arylformamidase	152						cytosol|nucleus	arylformamidase activity			autonomic_ganglia(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|skin(1)	19			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			CAGAAGCGGTATCCAAGCAAC	0.557000													11	26					0	0	0.000673	0	0
GSC	145258	broad.mit.edu	37	14	95234861	95234861	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95234861C>A	ENST00000238558.3	-	3	950	c.741G>T	c.(739-741)gaG>gaT	p.E247D		NM_173849.2	NP_776248.1	P56915	GSC_HUMAN	goosecoid homeobox	247					gastrulation|middle ear morphogenesis		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1		all_cancers(154;0.0896)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.202)|Epithelial(152;0.239)		TTTTACCTTCCTCTTCCCTCT	0.562000													39	104					8.16277e-20	1.9161e-19	0.001485	1	0
DCAF12L1	139170	broad.mit.edu	37	X	125686094	125686094	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:125686094G>T	ENST00000371126.1	-	1	740	c.498C>A	c.(496-498)acC>acA	p.T166T		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	166										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						TTTCGCCGCCGGTGGCCAGAA	0.657000													22	7					3.62473e-10	7.0561e-10	0.001882	1	0
HRNR	388697	broad.mit.edu	37	1	152192079	152192079	+	Missense_Mutation	SNP	C	C	T	rs141565920		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:152192079C>T	ENST00000368801.2	-	3	2101	c.2026G>A	c.(2026-2028)Ggc>Agc	p.G676S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	676					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATGTTGGCCGTAGCTGGAA	0.587000													90	178					0	0	0.003610	0	0
MS4A3	932	broad.mit.edu	37	11	59829952	59829952	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:59829952C>A	ENST00000278865.3	+	3	241	c.168C>A	c.(166-168)atC>atA	p.I56I	MS4A3_ENST00000395032.2_Intron|MS4A3_ENST00000358152.2_Intron|MS4A3_ENST00000534744.1_Intron	NM_006138.4	NP_006129.4	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	56						endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			endometrium(4)|kidney(2)|lung(9)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		all_epithelial(135;0.245)				CCATCCAGATCCTGAATGCAG	0.423000													30	80					1.30897e-18	3.03361e-18	0.001786	1	0
CORO1B	57175	broad.mit.edu	37	11	67206199	67206199	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:67206199G>T	ENST00000393893.1	-	11	1390	c.1287C>A	c.(1285-1287)ccC>ccA	p.P429P	CORO1B_ENST00000539724.1_5'UTR|CORO1B_ENST00000341356.5_Silent_p.P429P	NM_001018070.2	NP_001018080.1	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	429					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			TGGTGGAGGCGGGGGCCCCTA	0.716000													3	7					1.23904e-05	2.12907e-05	0.000602	1	0
AUP1	550	broad.mit.edu	37	2	74754875	74754875	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:74754875G>A	ENST00000377526.3	-	8	1138	c.829C>T	c.(829-831)Cgc>Tgc	p.R277C		NM_181575.3	NP_853553.1	Q9Y679	AUP1_HUMAN	ancient ubiquitous protein 1	343						endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)	11						GACTGGGGGCGCAATCTGGGG	0.512000													50	129					0	0	0.003610	0	0
SALL1	6299	broad.mit.edu	37	16	51175026	51175026	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:51175026C>G	ENST00000440970.1	-	2	1247	c.816G>C	c.(814-816)gcG>gcC	p.A272A	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000251020.4_Silent_p.A369A|SALL1_ENST00000541611.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	369					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ATGATGAGACCGCTGGGTTGC	0.512000													14	37					0	0	0.001855	0	0
ADRA2B	151	broad.mit.edu	37	2	96780851	96780851	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:96780851C>A	ENST00000409345.3	-	1	1133	c.1038G>T	c.(1036-1038)gtG>gtT	p.V346V		NM_000682.5	NP_000673.2	P18089	ADA2B_HUMAN	adrenoceptor alpha 2B	349					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(3)	16					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CTATAGCACCCACGCCCCTGC	0.677000													7	16					0.00198382	0.00323176	0.001984	1	0
COL19A1	1310	broad.mit.edu	37	6	70847590	70847590	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:70847590T>A	ENST00000322773.4	+	19	1499	c.1397T>A	c.(1396-1398)cTa>cAa	p.L466Q	COL19A1_ENST00000393344.1_Missense_Mutation_p.L88Q	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	466	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						GAAACTGGACTACCAGGATTT	0.408000													36	104					0	0	0.001706	0	0
C5orf42	65250	broad.mit.edu	37	5	37181062	37181062	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:37181062C>A	ENST00000274258.7	-	27	5697	c.2110G>T	c.(2110-2112)Gag>Tag	p.E704*	C5orf42_ENST00000425232.2_Nonsense_Mutation_p.E1823*|C5orf42_ENST00000508244.1_Nonsense_Mutation_p.E1823*			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1823										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CTCTCCCTCTCAATATTGGGT	0.388000													9	33					4.68919e-08	8.65e-08	0.000673	1	0
C7orf10	79783	broad.mit.edu	37	7	40498771	40498771	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:40498771A>G	ENST00000309930.5	+	11	1005	c.981A>G	c.(979-981)aaA>aaG	p.K327K	C7orf10_ENST00000401647.2_Silent_p.K279K|C7orf10_ENST00000335693.4_Silent_p.K327K	NM_001193311.1|NM_024728.2	NP_001180240.1|NP_079004.1	Q9HAC7	CG010_HUMAN	chromosome 7 open reading frame 10	327							transferase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)	18						ACAATAGAAAAGAGCTTATTA	0.279000													7	31					0	0	0.003080	0	0
NLRP4	147945	broad.mit.edu	37	19	56370017	56370017	+	Silent	SNP	C	C	A	rs140509890		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:56370017C>A	ENST00000301295.6	+	3	1680	c.1258C>A	c.(1258-1260)Cgg>Agg	p.R420R	NLRP4_ENST00000587891.1_Silent_p.R345R|NLRP4_ENST00000346986.5_Silent_p.R420R	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	420	NACHT.						ATP binding	p.R420W(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AGACGACCTCCGGAGAAATGG	0.582000													32	104					4.74835e-14	1.0021e-13	0.002096	1	0
CCNB3	85417	broad.mit.edu	37	X	50053222	50053222	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:50053222A>C	ENST00000376042.1	+	6	2351	c.2053A>C	c.(2053-2055)Aaa>Caa	p.K685Q	CCNB3_ENST00000276014.7_Missense_Mutation_p.K685Q|CCNB3_ENST00000376038.1_Intron|CCNB3_ENST00000348603.2_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	685					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					GCATACCAACAAAAGTGGGTC	0.463000													10	10					0	0	0.000673	0	0
LRAT	9227	broad.mit.edu	37	4	155665738	155665738	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:155665738G>T	ENST00000336356.3	+	2	513	c.260G>T	c.(259-261)cGc>cTc	p.R87L	LRAT_ENST00000507827.1_Missense_Mutation_p.R87L	NM_004744.3	NP_004735.2	O95237	LRAT_HUMAN	lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)	87					response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)	16	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	GACATGGGGCGCACGCAGAAG	0.597000													20	51					1.56452e-12	3.17814e-12	0.000958	1	0
PEBP4	157310	broad.mit.edu	37	8	22675246	22675246	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:22675246G>T	ENST00000256404.6	-	4	352	c.261C>A	c.(259-261)ggC>ggA	p.G87G	PEBP4_ENST00000521284.1_5'UTR	NM_144962.2	NP_659399.2	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	87						lysosome				breast(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)|stomach(2)	10		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		TATAGGTTGCGCCCTGTAACA	0.493000													29	56					5.45727e-16	1.21025e-15	0.001512	1	0
CPSF1	29894	broad.mit.edu	37	8	145626066	145626066	+	Splice_Site	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:145626066C>T	ENST00000349769.3	-	7	779	c.686_splice	c.e7+1	p.G229_splice		NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa	229					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			GGGGCTCACCCAGGCCAGGTC	0.637000													8	19					0	0	0.003080	0	0
CCNB3	85417	broad.mit.edu	37	X	50052855	50052855	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:50052855T>A	ENST00000376042.1	+	6	1984	c.1686T>A	c.(1684-1686)tcT>tcA	p.S562S	CCNB3_ENST00000276014.7_Silent_p.S562S|CCNB3_ENST00000376038.1_Intron|CCNB3_ENST00000348603.2_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	562					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					ATAAGAATTCTTTCTTTATGG	0.373000													10	10					0	0	0.000443	0	0
ZNF385D	79750	broad.mit.edu	37	3	21606087	21606087	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:21606087G>T	ENST00000281523.2	-	3	773	c.255C>A	c.(253-255)tgC>tgA	p.C85*	ZNF385D-AS1_ENST00000412369.1_RNA|ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	85						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						ATCTCAACTGGCAAATGTTGC	0.343000													15	28					3.27435e-08	6.06798e-08	0.002450	1	0
OR13C9	286362	broad.mit.edu	37	9	107379790	107379790	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:107379790C>T	ENST00000259362.1	-	1	695	c.696G>A	c.(694-696)gaG>gaA	p.E232E		NM_001001956.1	NP_001001956.1	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C, member 9	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(9)|prostate(1)|skin(4)	22						TGCTTCTCCCCTCAGAGGAGT	0.428000													19	85					0	0	0.000958	0	0
PRRC2B	84726	broad.mit.edu	37	9	134350269	134350269	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:134350269G>T	ENST00000357304.4	+	15	2808	c.2753G>T	c.(2752-2754)tGg>tTg	p.W918L	PRRC2B_ENST00000405995.1_Intron|PRRC2B_ENST00000372249.1_5'UTR|PRRC2B_ENST00000458550.1_Intron	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	918							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						GAGCCTGAATGGACTCCCGAG	0.642000													8	8					5.18039e-06	9.03305e-06	0.003080	1	0
HSPA13	6782	broad.mit.edu	37	21	15746151	15746151	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:15746151C>A	ENST00000285667.3	-	5	1270	c.1203G>T	c.(1201-1203)gaG>gaT	p.E401D	HSPA13_ENST00000544452.1_Missense_Mutation_p.E193D	NM_006948.4	NP_008879.3	P48723	HSP13_HUMAN	heat shock protein 70kDa family, member 13	401						endoplasmic reticulum|microsome	ATP binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						CTAAAACCACCTCATCAATCT	0.438000													55	85					2.31418e-15	5.04844e-15	0.003610	1	0
EPHA8	2046	broad.mit.edu	37	1	22927255	22927255	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:22927255G>T	ENST00000166244.3	+	14	2562	c.2490G>T	c.(2488-2490)gaG>gaT	p.E830D		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	830	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCATGTGGGAGGTGCTGGCCT	0.682000													55	45					6.60958e-23	1.61576e-22	0.003610	1	0
CD226	10666	broad.mit.edu	37	18	67562961	67562961	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:67562961C>A	ENST00000280200.4	-	4	971	c.703G>T	c.(703-705)Gtg>Ttg	p.V235L	CD226_ENST00000577287.1_Missense_Mutation_p.V80L|CD226_ENST00000582621.1_Missense_Mutation_p.V235L|CD226_ENST00000581982.1_Missense_Mutation_p.V80L	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	235	Ig-like C2-type 2.				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				AATCTCATCACGAAGGTTTCG	0.532000													84	72					1.29045e-55	3.33325e-55	0.003610	1	0
COBL	23242	broad.mit.edu	37	7	51261227	51261227	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:51261227T>A	ENST00000395542.2	-	3	489	c.305A>T	c.(304-306)cAc>cTc	p.H102L	COBL_ENST00000395540.2_Missense_Mutation_p.H102L|COBL_ENST00000441453.1_Missense_Mutation_p.H102L|COBL_ENST00000265136.7_Missense_Mutation_p.H102L			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	102										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					AAGGGCATGGTGGGATGGATT	0.413000													10	45					0	0	0.000443	0	0
APOB	338	broad.mit.edu	37	2	21235485	21235485	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:21235485T>A	ENST00000233242.1	-	26	4382	c.4255A>T	c.(4255-4257)Aca>Tca	p.T1419S		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1419					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity	p.T1419A(1)		NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TATGATAGTGTGAACGTATTC	0.343000													9	45					0	0	0.004482	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84608333	84608333	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:84608333T>C	ENST00000344803.2	+	4	2995	c.2948T>C	c.(2947-2949)cTt>cCt	p.L983P		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		GTCCCCATCCTTGATCGTCCT	0.488000													67	124					0	0	0.003610	0	0
CRISP2	7180	broad.mit.edu	37	6	49665662	49665662	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:49665662C>A	ENST00000339139.4	-	8	662	c.426G>T	c.(424-426)tgG>tgT	p.W142C		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	142						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AAGTCGAGTACCAAACAAGCT	0.313000													20	128					8.34094e-07	1.48407e-06	0.001216	1	0
STXBP5L	9515	broad.mit.edu	37	3	121001149	121001149	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:121001149C>A	ENST00000273666.6	+	20	2418	c.2147C>A	c.(2146-2148)cCt>cAt	p.P716H	STXBP5L_ENST00000497029.1_Missense_Mutation_p.P716H|STXBP5L_ENST00000471454.1_Intron|STXBP5L_ENST00000472879.1_Intron|STXBP5L_ENST00000492541.1_Missense_Mutation_p.P716H	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	716					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		AACTTTTATCCTGATTTAACG	0.383000													15	54					1.3612e-06	2.40699e-06	0.003163	1	0
GLUL	2752	broad.mit.edu	37	1	182354693	182354693	+	Splice_Site	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:182354693T>C	ENST00000311223.5	-	7	1500		c.e7-2		GLUL_ENST00000491322.1_5'UTR|GLUL_ENST00000331872.6_Splice_Site|GLUL_ENST00000417584.2_Splice_Site|GLUL_ENST00000339526.4_Splice_Site	NM_002065.5	NP_002056.2	P15104	GLNA_HUMAN	glutamate-ammonia ligase						cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding			endometrium(2)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	16					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	AAATTCCCACTAGAAACGAGA	0.463000													19	51					0	0	0.006122	0	0
CCDC47	57003	broad.mit.edu	37	17	61843413	61843413	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:61843413T>C	ENST00000225726.5	-	2	505	c.123A>G	c.(121-123)gaA>gaG	p.E41E	CCDC47_ENST00000582252.1_Silent_p.E41E|CCDC47_ENST00000403162.3_Silent_p.E41E	NM_020198.2	NP_064583.2	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47	41						integral to membrane	protein binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	18						CATCCTCAAATTCAGCGAAGT	0.443000													59	129					0	0	0.003610	0	0
TRIM51	84767	broad.mit.edu	37	11	55658953	55658953	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55658953G>T	ENST00000449290.2	+	7	1296	c.1204G>T	c.(1204-1206)Gtt>Ttt	p.V402F	TRIM51_ENST00000244891.3_Missense_Mutation_p.V259F	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	402	B30.2/SPRY.					intracellular	zinc ion binding										GGTGCAATATGTTCCAAGACC	0.458000													23	65					2.44723e-14	5.21401e-14	0.004656	1	0
GPR101	83550	broad.mit.edu	37	X	136112422	136112422	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:136112422T>A	ENST00000298110.1	-	1	1411	c.1412A>T	c.(1411-1413)aAg>aTg	p.K471M		NM_054021.1	NP_473362.1	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	471						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					GCAGAAGAACTTCTTCAGCAT	0.493000													39	20					0	0	0.005524	0	0
AP5Z1	9907	broad.mit.edu	37	7	4830976	4830976	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:4830976G>T	ENST00000348624.4	+	17	2478	c.2384G>T	c.(2383-2385)aGc>aTc	p.S795I	AP5Z1_ENST00000490487.1_3'UTR	NM_014855.2	NP_055670.1	O43299	K0415_HUMAN	adaptor-related protein complex 5, zeta 1 subunit	795					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding										CGCACGGTCAGCCGGCTGGTG	0.672000													8	7					1.12685e-05	1.94295e-05	0.004482	1	0
JAKMIP1	152789	broad.mit.edu	37	4	6107405	6107405	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:6107405G>T	ENST00000409021.3	-	3	868	c.419C>A	c.(418-420)gCg>gAg	p.A140E	JAKMIP1_ENST00000409371.3_Intron|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.A140E|JAKMIP1_ENST00000457227.2_Intron|JAKMIP1_ENST00000410077.2_Intron|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.A140E	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	140	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GGCCCTGCGCGCCTCCTCGCG	0.701000													5	9					3.59834e-05	6.09954e-05	0.001168	1	0
INHBC	3626	broad.mit.edu	37	12	57843137	57843137	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:57843137C>G	ENST00000309668.2	+	2	518	c.391C>G	c.(391-393)Cag>Gag	p.Q131E	INHBC_ENST00000550133.1_Missense_Mutation_p.Q131E	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	131					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						GGAGGTCCAGCAGGCCAGTCT	0.507000													65	181					0	0	0.003610	0	0
STK3	6788	broad.mit.edu	37	8	99779536	99779536	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:99779536T>A	ENST00000523601.1	-	5	654	c.255A>T	c.(253-255)caA>caT	p.Q85H	STK3_ENST00000419617.2_Missense_Mutation_p.Q57H	NM_001256312.1	NP_001243241.1	Q13188	STK3_HUMAN	serine/threonine kinase 3	57	Protein kinase.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		CAACAGGTACTTGTTTAATTG	0.328000													15	37					0	0	0.003163	0	0
ABCA8	10351	broad.mit.edu	37	17	66871844	66871844	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:66871844C>G	ENST00000269080.2	-	34	4418	c.4281G>C	c.(4279-4281)acG>acC	p.T1427T	ABCA8_ENST00000586539.1_Silent_p.T1467T|ABCA8_ENST00000430352.2_Silent_p.T1467T	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1427	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					CACCCCTTTCCGTGTTTCTAA	0.488000													12	32					0	0	0.002450	0	0
AMDHD2	51005	broad.mit.edu	37	16	2578355	2578355	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:2578355G>C	ENST00000302956.4	+	7	930	c.836G>C	c.(835-837)cGg>cCg	p.R279P	AMDHD2_ENST00000293971.6_Missense_Mutation_p.R279P|AMDHD2_ENST00000413459.3_Missense_Mutation_p.R279P|AMDHD2_ENST00000565570.1_Intron|CEMP1_ENST00000382350.1_Intron			Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2	279					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(3)|skin(2)|urinary_tract(2)	19						GCCGCCCTGCGGATCGCCCAC	0.672000													15	68					0	0	0.004007	0	0
SEMA5B	54437	broad.mit.edu	37	3	122642512	122642512	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:122642512G>T	ENST00000195173.4	-	10	1527	c.1224C>A	c.(1222-1224)aaC>aaA	p.N408K	SEMA5B_ENST00000357599.3_Missense_Mutation_p.N408K|SEMA5B_ENST00000451055.2_Missense_Mutation_p.N462K			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	408	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		CAGCCCTGGGGTTCTCCTGGT	0.557000													31	135					1.88708e-17	4.26987e-17	0.001512	1	0
RYR1	6261	broad.mit.edu	37	19	38956797	38956797	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:38956797G>C	ENST00000355481.4	+	24	3068	c.2937G>C	c.(2935-2937)gcG>gcC	p.A979A	RYR1_ENST00000360985.3_Silent_p.A979A|RYR1_ENST00000359596.3_Silent_p.A979A	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	979	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGACGCCGGCGCAGACGACAC	0.652000													7	18					0	0	0.001984	0	0
E2F2	1870	broad.mit.edu	37	1	23857277	23857277	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:23857277T>A	ENST00000361729.2	-	1	435	c.9A>T	c.(7-9)caA>caT	p.Q3H		NM_004091.3	NP_004082.1	Q14209	E2F2_HUMAN	E2F transcription factor 2	3					G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|large_intestine(2)|lung(1)|ovary(3)|skin(2)|urinary_tract(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)		CCCGGGGCCCTTGCAGCATAG	0.721000													9	7					0	0	0.004482	0	0
AFP	174	broad.mit.edu	37	4	74318195	74318195	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:74318195T>A	ENST00000395792.2	+	12	1606	c.1506T>A	c.(1504-1506)acT>acA	p.T502T	AFP_ENST00000226359.2_Silent_p.T502T	NM_001134.1	NP_001125.1	P02771	FETA_HUMAN	alpha-fetoprotein	502	Albumin 3.				transport		metal ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|urinary_tract(1)	22	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGTGCTGCACTTCTTCATATG	0.443000									Alpha-Fetoprotein, Hereditary Persistence of				27	76					0	0	0.001061	0	0
WDR26	80232	broad.mit.edu	37	1	224585902	224585902	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:224585902G>C	ENST00000414423.2	-	12	1864	c.1671C>G	c.(1669-1671)gaC>gaG	p.D557E	WDR26_ENST00000366852.2_3'UTR|WDR26_ENST00000295024.6_Missense_Mutation_p.D410E|WDR26_ENST00000479727.1_5'UTR	NM_001115113.2|NM_025160.6	NP_001108585.2|NP_079436.4	Q9H7D7	WDR26_HUMAN	WD repeat domain 26	557						cytoplasm|nucleus				biliary_tract(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)	18				GBM - Glioblastoma multiforme(131;0.0104)		CTAAAACTCTGTCTTGCAAGT	0.358000													10	18					0	0	0.000443	0	0
THY1	7070	broad.mit.edu	37	11	119290994	119290994	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:119290994G>T	ENST00000284240.5	-	3	1179	c.140C>A	c.(139-141)cCc>cAc	p.P47H	USP2-AS1_ENST00000578923.1_RNA|USP2-AS1_ENST00000498979.2_RNA|THY1_ENST00000527590.1_5'UTR|USP2-AS1_ENST00000530002.1_RNA|USP2-AS1_ENST00000500970.1_RNA|THY1_ENST00000580275.1_Missense_Mutation_p.P30H|THY1_ENST00000528522.1_Missense_Mutation_p.P47H	NM_006288.3	NP_006279.2	P04216	THY1_HUMAN	Thy-1 cell surface antigen	47	Ig-like V-type.				angiogenesis|cell-cell adhesion|cytoskeleton organization|focal adhesion assembly|negative regulation of axonogenesis|negative regulation of cell migration|negative regulation of protein kinase activity|negative regulation of T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell activation|retinal cone cell development|T cell receptor signaling pathway	endoplasmic reticulum|growth cone|integral to plasma membrane|membrane raft	GPI anchor binding|integrin binding|Rho GTPase activator activity	p.P47H(1)		breast(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.83e-05)		GTACTGGATGGGTGAACTGCT	0.587000													38	96					1.49673e-21	3.59754e-21	0.001287	1	0
DGKI	9162	broad.mit.edu	37	7	137237200	137237200	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:137237200G>T	ENST00000453654.1	-	20	1701	c.1162C>A	c.(1162-1164)Cca>Aca	p.P388T	DGKI_ENST00000446122.1_Missense_Mutation_p.P688T|DGKI_ENST00000288490.5_Missense_Mutation_p.P688T|DGKI_ENST00000424189.2_Missense_Mutation_p.P688T			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	688	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						ATCATAGCTGGGGCCAACCTA	0.517000													40	98					6.04917e-29	1.5138e-28	0.001485	1	0
ARRDC5	645432	broad.mit.edu	37	19	4891178	4891178	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:4891178C>A	ENST00000381781.2	-	3	908	c.909G>T	c.(907-909)tgG>tgT	p.W303C		NM_001080523.1	NP_001073992.1	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	303					signal transduction					endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		TGGTCAGGGACCAGGGCAGGT	0.607000													52	132					2.30037e-20	5.45081e-20	0.003610	1	0
DIRAS1	148252	broad.mit.edu	37	19	2717513	2717513	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:2717513C>T	ENST00000323469.4	-	2	475	c.292G>A	c.(292-294)Ggg>Agg	p.G98R	DIRAS1_ENST00000585334.1_Missense_Mutation_p.G98R	NM_145173.3	NP_660156.1	O95057	DIRA1_HUMAN	DIRAS family, GTP-binding RAS-like 1	98					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			kidney(1)|lung(2)|ovary(2)|prostate(1)	6				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGATGGGCCCCAGCTCCTCC	0.627000													17	26					0	0	0.006122	0	0
ZNF354C	30832	broad.mit.edu	37	5	178503532	178503532	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:178503532G>T	ENST00000315475.6	+	3	420	c.114G>T	c.(112-114)cgG>cgT	p.R38R		NM_014594.1	NP_055409.1	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	38	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|urinary_tract(3)	30	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		CCTTGTACCGGGAGGTGATGC	0.527000													24	82					6.36457e-07	1.14051e-06	0.003954	1	0
TRPC5	7224	broad.mit.edu	37	X	111078301	111078301	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:111078301G>T	ENST00000262839.2	-	7	2662	c.1744C>A	c.(1744-1746)Ctt>Att	p.L582I		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	582					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AGATTTAAAAGGCCAAATACA	0.398000													110	65					1.93806e-58	5.01249e-58	0.003610	1	0
LPPR5	163404	broad.mit.edu	37	1	99418732	99418732	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:99418732C>A	ENST00000370188.3	-	3	875	c.515G>T	c.(514-516)aGt>aTt	p.S172I	LPPR5_ENST00000263177.4_Missense_Mutation_p.S172I	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		172						integral to membrane	hydrolase activity										CTCTTCCCCACTGATGAATTG	0.478000													32	24					1.88708e-17	4.26987e-17	0.001512	1	0
IKBIP	121457	broad.mit.edu	37	12	99007656	99007656	+	Missense_Mutation	SNP	C	C	A	rs147943089	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:99007656C>A	ENST00000342502.2	-	3	1171	c.760G>T	c.(760-762)Gac>Tac	p.D254Y	IKBIP_ENST00000420861.1_Missense_Mutation_p.D148Y|IKBIP_ENST00000393042.3_3'UTR	NM_201612.2	NP_963906.1	Q70UQ0	IKIP_HUMAN	IKBKB interacting protein	254					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(2)	6						GTATGTTTGTCGAAGTCACTC	0.378000													20	68					2.4624e-09	4.69775e-09	0.001216	1	0
KALRN	8997	broad.mit.edu	37	3	124377324	124377324	+	Missense_Mutation	SNP	G	G	T	rs144160219	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:124377324G>T	ENST00000360013.3	+	42	6207	c.6080G>T	c.(6079-6081)cGc>cTc	p.R2027L	KALRN_ENST00000393496.1_Missense_Mutation_p.R368L|KALRN_ENST00000291478.4_Missense_Mutation_p.R330L|KALRN_ENST00000459915.1_Missense_Mutation_p.R119L|KALRN_ENST00000428018.2_Missense_Mutation_p.R298L	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2026	DH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AATAAGCCGCGCTCAGAGTAC	0.507000													24	99					1.17739e-12	2.39901e-12	0.005443	1	0
CSMD3	114788	broad.mit.edu	37	8	113256746	113256746	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:113256746G>T	ENST00000297405.5	-	65	10523	c.10279C>A	c.(10279-10281)Ctt>Att	p.L3427I	CSMD3_ENST00000455883.2_Missense_Mutation_p.L3258I|CSMD3_ENST00000343508.3_Missense_Mutation_p.L3387I|CSMD3_ENST00000352409.3_Missense_Mutation_p.L3357I	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3427	Sushi 28.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGAGATGGAAGGTCCATCCCT	0.418000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	50					0.000308642	0.000509831	0.003163	1	0
EBF4	57593	broad.mit.edu	37	20	2688610	2688610	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:2688610G>A	ENST00000380648.4	+	6	688	c.420G>A	c.(418-420)ggG>ggA	p.G140G	EBF4_ENST00000342725.4_Silent_p.G144G	NM_001110514.1	NP_001103984.1	Q9BQW3	COE4_HUMAN	early B-cell factor 4	144					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding										TCTATGAGGGGCAGGACAAGA	0.612000													5	13					0	0	0.001168	0	0
CUBN	8029	broad.mit.edu	37	10	16946023	16946023	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:16946023G>T	ENST00000377833.4	-	51	8069	c.8004C>A	c.(8002-8004)caC>caA	p.H2668Q		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2668	CUB 19.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGGTGACAAAGTGAATCCATA	0.378000													11	25					2.80697e-09	5.32476e-09	0.000978	1	0
OR5J2	282775	broad.mit.edu	37	11	55944846	55944846	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55944846C>A	ENST00000312298.1	+	1	753	c.753C>A	c.(751-753)ttC>ttA	p.F251L		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					TGACCATATTCTATGGTACCT	0.453000													34	92					2.68265e-12	5.41113e-12	0.002836	1	0
RAB11FIP5	26056	broad.mit.edu	37	2	73315801	73315801	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:73315801C>G	ENST00000258098.6	-	3	1185	c.945G>C	c.(943-945)gtG>gtC	p.V315V	RAB11FIP5_ENST00000493523.2_5'UTR	NM_015470.2	NP_056285.1	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	315					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding			biliary_tract(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	23						GAGGAGGAGCCACTCGCATCT	0.592000													6	23					0	0	0.001984	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12908094	12908094	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:12908094G>C	ENST00000317869.6	-	2	274	c.49C>G	c.(49-51)Cgt>Ggt	p.R17G		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						ATGAACACACGGGAGTTCATG	0.463000													33	111					0	0	0.002836	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133672524	133672524	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:133672524T>A	ENST00000310926.4	-	5	980	c.707A>T	c.(706-708)tAt>tTt	p.Y236F	SLCO2A1_ENST00000493729.1_Missense_Mutation_p.Y160F	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	236					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GACCCTGCCATAGTCCACAAA	0.522000													64	58					0	0	0.003610	0	0
LRFN5	145581	broad.mit.edu	37	14	42355978	42355978	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:42355978C>A	ENST00000554171.1	+	5	2582	c.150C>A	c.(148-150)gaC>gaA	p.D50E	LRFN5_ENST00000298119.4_Missense_Mutation_p.D50E|LRFN5_ENST00000554120.1_Missense_Mutation_p.D50E			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	50	LRRNT.					integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CAAACATTGACAGAAGAACTG	0.413000										HNSCC(30;0.082)			15	23					1.49906e-05	2.56927e-05	0.002450	1	0
ROCK1	6093	broad.mit.edu	37	18	18572799	18572799	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:18572799G>A	ENST00000399799.1	-	17	2925	c.1985C>T	c.(1984-1986)tCa>tTa	p.S662L		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	662	Glu-rich.|Interaction with FHOD1.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					TACCTTTTCTGAGTGATTAAG	0.303000													20	20					0	0	0.001216	0	0
OR4K2	390431	broad.mit.edu	37	14	20345255	20345255	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20345255A>T	ENST00000298642.2	+	1	865	c.829A>T	c.(829-831)Atc>Ttc	p.I277F		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTTTTATACCATCTTTACTCC	0.358000													23	119					0	0	0.002780	0	0
NME8	51314	broad.mit.edu	37	7	37903047	37903047	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:37903047C>A	ENST00000199447.4	+	8	809	c.437C>A	c.(436-438)tCa>tAa	p.S146*	NME8_ENST00000440017.1_Nonsense_Mutation_p.S146*|EPDR1_ENST00000476620.1_Intron	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	146					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										AGTGAAGAATCACCATGTGAA	0.348000													20	59					2.94398e-08	5.46584e-08	0.000958	1	0
OR1L6	392390	broad.mit.edu	37	9	125512443	125512443	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:125512443T>C	ENST00000373684.1	+	1	425	c.425T>C	c.(424-426)aTg>aCg	p.M142T	OR1L6_ENST00000304720.2_Missense_Mutation_p.M106T			Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						TACTTCTTTATGGCATTTGGG	0.488000													34	148					0	0	0.003755	0	0
SBNO1	55206	broad.mit.edu	37	12	123780568	123780568	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:123780568G>A	ENST00000420886.2	-	31	4068	c.4069C>T	c.(4069-4071)Cct>Tct	p.P1357S	SBNO1_ENST00000602398.1_Missense_Mutation_p.P1357S|SBNO1_ENST00000267176.4_Missense_Mutation_p.P1356S|SBNO1_ENST00000602750.1_Missense_Mutation_p.P1356S	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	1357							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TTTACAAGAGGAGACACACAA	0.428000													46	104					0	0	0.002222	0	0
ZNF99	7652	broad.mit.edu	37	19	22940748	22940748	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:22940748C>T	ENST00000397104.3	-	5	1689	c.1690G>A	c.(1690-1692)Ggt>Agt	p.G564S	ZNF99_ENST00000596209.1_Missense_Mutation_p.G655S					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAAGCTTTACCACATTCTTCA	0.378000													11	49					0	0	0.001855	0	0
C4orf6	10141	broad.mit.edu	37	4	5527953	5527953	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:5527953C>T	ENST00000195455.2	+	2	352	c.177C>T	c.(175-177)gaC>gaT	p.D59D	C4orf6_ENST00000515342.1_3'UTR	NM_005750.2	NP_005741.1	Q99440	CD006_HUMAN	chromosome 4 open reading frame 6	59					nervous system development					large_intestine(1)|prostate(1)	2						GAACTGCAGACACTGCAGATA	0.448000													18	51					0	0	0.001216	0	0
EGFLAM	133584	broad.mit.edu	37	5	38438424	38438424	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:38438424C>T	ENST00000322350.5	+	17	2677	c.2331C>T	c.(2329-2331)tcC>tcT	p.S777S	EGFLAM_ENST00000397202.2_Silent_p.S143S|EGFLAM_ENST00000354891.3_Silent_p.S777S|EGFLAM_ENST00000336740.6_Silent_p.S543S	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	777	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					ACTTCACCTCCGGAGTGAATG	0.512000													15	43					0	0	0.004990	0	0
OR2T34	127068	broad.mit.edu	37	1	248737333	248737333	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248737333G>A	ENST00000328782.2	-	1	747	c.726C>T	c.(724-726)gcC>gcT	p.A242A		NM_001001821.1	NP_001001821.1	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T, member 34	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(28)|ovary(2)|skin(2)|stomach(3)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGTGGCCAAGGCCTTCCTGC	0.567000													112	127					0	0	0.003610	0	0
SPTY2D1	144108	broad.mit.edu	37	11	18637522	18637522	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:18637522G>T	ENST00000336349.5	-	3	534	c.299C>A	c.(298-300)cCt>cAt	p.P100H	SPTY2D1_ENST00000543776.1_5'UTR	NM_194285.2	NP_919261.2	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)	100										breast(4)|cervix(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|skin(1)|stomach(1)	30						TTCCTCAATAGGAATCCCATT	0.433000													54	87					1.0331e-37	2.6413e-37	0.003610	1	0
JARID2	3720	broad.mit.edu	37	6	15452388	15452388	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:15452388A>C	ENST00000341776.2	+	4	719	c.475A>C	c.(475-477)Acc>Ccc	p.T159P	JARID2_ENST00000397311.3_5'UTR|JARID2_ENST00000541660.1_Missense_Mutation_p.T121P	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	159					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGATTTTCTTACCTTTCTCTG	0.468000													26	85					0	0	0.001786	0	0
FLRT3	23767	broad.mit.edu	37	20	14306911	14306911	+	Silent	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:14306911A>C	ENST00000378053.3	-	2	1498	c.1242T>G	c.(1240-1242)acT>acG	p.T414T	FLRT3_ENST00000341420.4_Silent_p.T414T|MACROD2_ENST00000310348.4_Intron|MACROD2_ENST00000217246.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	414	Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		CAGACTTCACAGTAATTGTAA	0.468000													46	117					0	0	0.003610	0	0
RPL23AP82	284942	broad.mit.edu	37	22	51237503	51237503	+	RNA	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:51237503C>G	ENST00000480246.1	+	0	753					NR_026982.1																						GTTCGACTTGCTCCTGATTAT	0.418000													29	20					0	0	0.004289	0	0
OR5R1	219479	broad.mit.edu	37	11	56185379	56185379	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56185379A>T	ENST00000312253.1	-	1	329	c.330T>A	c.(328-330)acT>acA	p.T110T		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					GGAAACACTCAGTGATCATGA	0.453000													15	37					0	0	0.004007	0	0
NCR2	9436	broad.mit.edu	37	6	41304148	41304148	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:41304148T>G	ENST00000373083.4	+	2	598	c.376T>G	c.(376-378)Tat>Gat	p.Y126D	NCR2_ENST00000373086.3_Missense_Mutation_p.Y126D|NCR2_ENST00000373089.5_Missense_Mutation_p.Y126D	NM_001199510.1	NP_001186439.1	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	126					cellular defense response	integral to plasma membrane	transmembrane receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	14	Ovarian(28;0.0327)|Colorectal(47;0.196)					CGTCAGATTCTATCTGGTGGT	0.532000													59	31					0	0	0.003610	0	0
NAALADL2	254827	broad.mit.edu	37	3	175184791	175184791	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:175184791A>G	ENST00000454872.1	+	8	1480	c.1352A>G	c.(1351-1353)cAt>cGt	p.H451R	NAALADL2_ENST00000473253.1_3'UTR	NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	451					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		GTTGGCAGCCATCATCACACT	0.363000													66	310					0	0	0.003610	0	0
CADM4	199731	broad.mit.edu	37	19	44131332	44131332	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:44131332G>T	ENST00000222374.2	-	3	398	c.350C>A	c.(349-351)aCg>aAg	p.T117K		NM_145296.1	NP_660339.1	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4	117	Ig-like V-type.				cell adhesion	integral to membrane				endometrium(2)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	12		Prostate(69;0.0199)				TACCGTGAGCGTGGCAATCTG	0.587000													26	71					2.46105e-21	5.89419e-21	0.002096	1	0
TXNRD3NB	645840	broad.mit.edu	37	3	126291216	126291216	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:126291216C>A	ENST00000383572.2	-	3	649	c.171G>T	c.(169-171)ggG>ggT	p.G57G	TXNRD3NB_ENST00000404489.2_Silent_p.G57G	NM_001039783.1	NP_001034872.1	Q6F5E7	TR3N_HUMAN	thioredoxin reductase 3 neighbor	57										endometrium(1)|large_intestine(2)|skin(2)	5						GACTGGGAAACCCCTGTCCAA	0.547000													22	90					0.00278032	0.0045183	0.002780	1	0
POTEG	404785	broad.mit.edu	37	14	19553561	19553561	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:19553561C>G	ENST00000409832.3	+	1	197	c.145C>G	c.(145-147)Cac>Gac	p.H49D		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	49										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						TTCTGGAGACCACGACGATTC	0.607000													42	900					0	0	0.003214	0	0
THBD	7056	broad.mit.edu	37	20	23029284	23029284	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23029284C>A	ENST00000377103.2	-	1	1094	c.858G>T	c.(856-858)caG>caT	p.Q286H		NM_000361.2	NP_000352.1	P07204	TRBM_HUMAN	thrombomodulin	286	EGF-like 2.				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity			endometrium(2)|large_intestine(3)|ovary(1)|skin(1)	7	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	CGTTGCAGGACTGCGTCGCGG	0.716000													10	15					0.000442599	0.000729907	0.000443	1	0
FAP	2191	broad.mit.edu	37	2	163027550	163027550	+	Missense_Mutation	SNP	G	G	T	rs138652824		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:163027550G>T	ENST00000188790.4	-	26	2429	c.2222C>A	c.(2221-2223)aCg>aAg	p.T741K	AC007750.5_ENST00000418968.2_RNA|FAP_ENST00000443424.1_Missense_Mutation_p.T716K	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	741					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity	p.T741K(1)		NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						TAAGTGGTTCGTGGACAGGCC	0.433000													28	38					7.38237e-10	1.43016e-09	0.001061	1	0
ADAM19	8728	broad.mit.edu	37	5	156929850	156929850	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:156929850A>T	ENST00000257527.4	-	12	1347	c.1269T>A	c.(1267-1269)taT>taA	p.Y423*	ADAM19_ENST00000394020.1_Nonsense_Mutation_p.Y425*|ADAM19_ENST00000517905.1_Nonsense_Mutation_p.Y423*|ADAM19_ENST00000430702.2_Nonsense_Mutation_p.Y156*	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	423	Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CATCTTCCAGATACCCGTTCC	0.527000													44	107					0	0	0.003610	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95108185	95108185	+	RNA	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95108185G>A	ENST00000469935.1	+	0	790					NR_015340.1																						CCTGGGAGAAGGACCTCGGCA	0.572000													49	103					0	0	0.003610	0	0
ACSM5	54988	broad.mit.edu	37	16	20442556	20442556	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:20442556G>A	ENST00000331849.4	+	10	1368	c.1221G>A	c.(1219-1221)gaG>gaA	p.E407E		NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	407					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						TGGATGATGAGGGCAACGTCC	0.557000													37	129					0	0	0.001706	0	0
BPIFB2	80341	broad.mit.edu	37	20	31601615	31601615	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:31601615G>T	ENST00000170150.3	+	5	503		c.e5-1			NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2							extracellular region	lipid binding										CATCCCTACAGCGCCCCAGAG	0.637000													18	58					3.32936e-07	6.00901e-07	0.006122	1	0
USP13	8975	broad.mit.edu	37	3	179418886	179418886	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:179418886C>A	ENST00000263966.3	+	4	917	c.446C>A	c.(445-447)gCa>gAa	p.A149E	USP13_ENST00000482333.1_3'UTR|USP13_ENST00000496897.1_Missense_Mutation_p.A84E	NM_003940.2	NP_003931.2	Q92995	UBP13_HUMAN	ubiquitin specific peptidase 13 (isopeptidase T-3)	149					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	46	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TATGAAATAGCACTACCAAAT	0.443000													41	56					4.14481e-20	9.7522e-20	0.001287	1	0
OR2A14	135941	broad.mit.edu	37	7	143826284	143826284	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:143826284T>C	ENST00000408899.2	+	1	134	c.79T>C	c.(79-81)Tgt>Cgt	p.C27R		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					GATTCTCCTCTGTGGACTTTT	0.502000													28	80					0	0	0.005443	0	0
SH2D3C	10044	broad.mit.edu	37	9	130506941	130506941	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:130506941G>T	ENST00000314830.8	-	7	1815	c.1702C>A	c.(1702-1704)Cgg>Agg	p.R568R	SH2D3C_ENST00000420366.1_Silent_p.R410R|SH2D3C_ENST00000471939.1_5'UTR|SH2D3C_ENST00000373276.3_Silent_p.R500R|SH2D3C_ENST00000373274.3_Silent_p.R408R|SH2D3C_ENST00000429553.1_Silent_p.R214R|SH2D3C_ENST00000373277.4_Silent_p.R411R	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	568					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TCCAGTGGCCGGTTATCCCTG	0.612000													48	135					5.34276e-22	1.29036e-21	0.003610	1	0
GPR98	84059	broad.mit.edu	37	5	89954097	89954097	+	Splice_Site	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:89954097T>A	ENST00000405460.2	+	21	4848		c.e21+2			NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98						cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATACCAGAGGTAAGTAGTGAG	0.373000													18	40					0	0	0.006122	0	0
OR4C6	219432	broad.mit.edu	37	11	55433552	55433552	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55433552G>T	ENST00000314259.3	+	1	939	c.910G>T	c.(910-912)Gag>Tag	p.E304*		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						GATGAAATGGGAGGCTTTGGC	0.408000													7	36					1.06961e-07	1.96047e-07	0.003080	1	0
CDH10	1008	broad.mit.edu	37	5	24537561	24537561	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:24537561C>A	ENST00000264463.4	-	3	961	c.454G>T	c.(454-456)Gat>Tat	p.D152Y		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	152	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TCATTGATATCATGAATTTTG	0.413000										HNSCC(23;0.051)			45	100					2.24893e-16	5.0207e-16	0.002222	1	0
PARP12	64761	broad.mit.edu	37	7	139756947	139756947	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:139756947G>A	ENST00000263549.3	-	3	1342	c.469C>T	c.(469-471)Caa>Taa	p.Q157*		NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	157						nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					TTGTAATGTTGGCAAATCTGT	0.498000													30	76					0	0	0.001061	0	0
OR8B3	390271	broad.mit.edu	37	11	124266529	124266529	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:124266529G>A	ENST00000354597.3	-	1	735	c.719C>T	c.(718-720)aCt>aTt	p.T240I		NM_001005467.1	NP_001005467.1	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B, member 3	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AGAGCTACAAGTACTGAAGGC	0.383000													24	92					0	0	0.004289	0	0
HECTD4	283450	broad.mit.edu	37	12	112670875	112670875	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:112670875C>G	ENST00000550722.1	-	38	5887	c.5492G>C	c.(5491-5493)cGg>cCg	p.R1831P	HECTD4_ENST00000377560.5_Missense_Mutation_p.R1805P|HECTD4_ENST00000430131.2_Missense_Mutation_p.R1555P	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TCGGAAGGGCCGTCCTTCTGA	0.512000													5	7					0	0	0.000602	0	0
PPT2-EGFL8	100532746	broad.mit.edu	37	6	32122555	32122555	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:32122555G>T	ENST00000422437.1	+	2	374		c.e2+1		PPT2-EGFL8_ENST00000453656.2_Splice_Site|PPT2_ENST00000493548.1_Splice_Site|PPT2_ENST00000375143.2_Splice_Site|PPT2_ENST00000375137.2_Splice_Site|PPT2_ENST00000361568.2_Splice_Site|PPT2_ENST00000395523.1_Splice_Site|PPT2_ENST00000437001.2_Splice_Site|PPT2_ENST00000324816.6_Splice_Site|PPT2_ENST00000445576.2_Splice_Site																							CATCAATGAGGTCTGGCAGGG	0.647000													32	39					1.88708e-17	4.26987e-17	0.001512	1	0
NRXN1	9378	broad.mit.edu	37	2	51254661	51254661	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:51254661G>T	ENST00000404971.1	-	2	2090	c.751C>A	c.(751-753)Cgc>Agc	p.R251S	NRXN1_ENST00000405472.3_Missense_Mutation_p.R251S|NRXN1_ENST00000402717.3_Missense_Mutation_p.R251S|NRXN1_ENST00000401669.2_Missense_Mutation_p.R251S|NRXN1_ENST00000405581.1_Missense_Mutation_p.R251S|NRXN1_ENST00000406316.2_Missense_Mutation_p.R251S|NRXN1_ENST00000406859.3_Missense_Mutation_p.R251S	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	251	EGF-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TCCTTGCCGCGGAAGCCGGTT	0.751000													5	30					0.000602214	0.000991505	0.000602	1	0
ADAMTSL1	92949	broad.mit.edu	37	9	18889647	18889647	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:18889647G>A	ENST00000380548.4	+	25	4883	c.4544G>A	c.(4543-4545)tGc>tAc	p.C1515Y	ADAMTSL1_ENST00000380545.5_Missense_Mutation_p.C216Y	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1515						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CGCTTGAGGTGCCTGCTGAAC	0.642000													8	20					0	0	0.003080	0	0
CREBZF	58487	broad.mit.edu	37	11	85375697	85375697	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:85375697C>A	ENST00000527447.1	-	1	449	c.223G>T	c.(223-225)Gtg>Ttg	p.V75L	CREBZF_ENST00000534224.1_Intron|CREBZF_ENST00000398294.2_5'UTR|CREBZF_ENST00000531515.1_Intron	NM_001039618.2	NP_001034707.1	Q9NS37	ZHANG_HUMAN	CREB/ATF bZIP transcription factor	75					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				GGCGCGCGCACGGCCACGCCG	0.706000													38	76					2.05212e-20	4.86832e-20	0.005524	1	0
CFAP54	144535	broad.mit.edu	37	12	97158856	97158856	+	Splice_Site	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:97158856T>C	ENST00000524981.3	+	27	3494	c.3492_splice	c.e27-1	p.V1165_splice				Q6ZTY8	CL063_HUMAN		1139										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						TAATTGTAGGTCAGTGAAGCT	0.274000													15	57					0	0	0.003163	0	0
SORBS2	8470	broad.mit.edu	37	4	186533086	186533086	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:186533086C>T	ENST00000431808.1	-	19	3495	c.2932G>A	c.(2932-2934)Ggt>Agt	p.G978S	SORBS2_ENST00000449407.2_Missense_Mutation_p.G522S|SORBS2_ENST00000448662.2_Missense_Mutation_p.G539S|SORBS2_ENST00000437304.2_Missense_Mutation_p.G702S|SORBS2_ENST00000498125.1_5'UTR|SORBS2_ENST00000393528.3_Missense_Mutation_p.G544S|SORBS2_ENST00000355634.5_Missense_Mutation_p.G1078S|SORBS2_ENST00000319471.9_Missense_Mutation_p.G609S|SORBS2_ENST00000284776.7_Missense_Mutation_p.G978S|SORBS2_ENST00000418609.1_Missense_Mutation_p.G882S			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	978	SH3 2.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GGGATTTTACCTTCATACCAG	0.398000													9	41					0	0	0.004482	0	0
GTF2E1	2960	broad.mit.edu	37	3	120469827	120469827	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:120469827A>T	ENST00000283875.5	+	2	521	c.428A>T	c.(427-429)cAg>cTg	p.Q143L		NM_005513.2	NP_005504.2	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1, alpha 56kDa	143					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding	p.Q143P(1)		NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)	22				GBM - Glioblastoma multiforme(114;0.159)		GAAGCTAATCAGCTCTTTGAT	0.353000													18	64					0	0	0.006122	0	0
DTD1	92675	broad.mit.edu	37	20	18724787	18724787	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:18724787G>T	ENST00000377452.3	+	5	701	c.521G>T	c.(520-522)aGa>aTa	p.R174I		NM_080820.4	NP_543010.3	Q8TEA8	DTD1_HUMAN	D-tyrosyl-tRNA deacylase 1	174					D-amino acid catabolic process	cytoplasm	hydrolase activity, acting on ester bonds			large_intestine(4)|lung(1)|ovary(2)	7						GAAAAGACCAGAGCTAAGGGA	0.448000													12	17					3.07112e-06	5.37379e-06	0.000978	1	0
VEPH1	79674	broad.mit.edu	37	3	157146130	157146130	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:157146130G>C	ENST00000362010.2	-	5	984	c.677C>G	c.(676-678)gCa>gGa	p.A226G	VEPH1_ENST00000469007.1_5'UTR|VEPH1_ENST00000392833.2_Missense_Mutation_p.A226G|VEPH1_ENST00000392832.2_Missense_Mutation_p.A226G|VEPH1_ENST00000543418.1_Missense_Mutation_p.A226G	NM_001167912.1	NP_001161384.1	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain-containing 1	226						plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TTTTTTCTTTGCTGCTACATG	0.438000													14	89					0	0	0.001855	0	0
OR2M3	127062	broad.mit.edu	37	1	248366998	248366998	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248366998C>A	ENST00000456743.1	+	1	667	c.629C>A	c.(628-630)cCt>cAt	p.P210H		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATTGTTTTCCCTGTTGCAATC	0.418000													168	236					5.60145e-70	1.45623e-69	0.003610	1	0
ECT2L	345930	broad.mit.edu	37	6	139170518	139170518	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:139170518A>C	ENST00000423192.1	+	8	1177	c.1016A>C	c.(1015-1017)cAg>cCg	p.Q339P	ECT2L_ENST00000495970.1_3'UTR|ECT2L_ENST00000367682.2_Missense_Mutation_p.Q339P|ECT2L_ENST00000541398.1_Missense_Mutation_p.Q270P			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	339					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						CAGAAGGCACAGAGCATCGGA	0.468000			"""N, Splice, Mis"""		ETP ALL								21	62					0	0	0.001216	0	0
WDR78	79819	broad.mit.edu	37	1	67359072	67359072	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:67359072C>A	ENST00000371026.3	-	3	425	c.370G>T	c.(370-372)Gtt>Ttt	p.V124F	WDR78_ENST00000371022.3_Missense_Mutation_p.V124F|WDR78_ENST00000431318.1_5'UTR|WDR78_ENST00000371023.3_Missense_Mutation_p.V124F	NM_024763.4	NP_079039.4	Q5VTH9	WDR78_HUMAN	WD repeat domain 78	124										NS(1)|endometrium(3)|kidney(6)|large_intestine(6)|lung(10)|ovary(3)|skin(3)	32						CGGGGAGTAACATCAGTTCCA	0.343000													26	19					2.48779e-11	4.96816e-11	0.005443	1	0
ANK2	287	broad.mit.edu	37	4	114274328	114274328	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:114274328C>A	ENST00000357077.4	+	38	4607	c.4554C>A	c.(4552-4554)acC>acA	p.T1518T	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Silent_p.T1485T|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1485					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCAAAATGACCGCCATCTTGA	0.458000													26	70					9.39395e-14	1.96802e-13	0.001061	1	0
SSB	6741	broad.mit.edu	37	2	170667535	170667535	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:170667535A>G	ENST00000409333.1	+	10	1225	c.978A>G	c.(976-978)ctA>ctG	p.L326L	SSB_ENST00000260956.4_Silent_p.L326L|METTL5_ENST00000409837.1_Intron			P05455	LA_HUMAN	Sjogren syndrome antigen B (autoantigen La)	326					histone mRNA metabolic process|tRNA modification	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding|tRNA binding			endometrium(3)|large_intestine(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						AAGAATCCCTAAACAAATGGA	0.333000													14	27					0	0	0.002450	0	0
SPAG8	26206	broad.mit.edu	37	9	35809452	35809452	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35809452C>A	ENST00000340291.2	-	7	1445	c.1321G>T	c.(1321-1323)Gaa>Taa	p.E441*	NPR2_ENST00000342694.2_3'UTR	NM_172312.1	NP_758516.1	Q99932	SPAG8_HUMAN	sperm associated antigen 8	0						acrosomal vesicle|membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			AACCCCCATTCTTTCCAAGTC	0.493000													99	244					3.37413e-40	8.64862e-40	0.003610	1	0
FREM2	341640	broad.mit.edu	37	13	39264040	39264040	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:39264040C>A	ENST00000280481.7	+	1	2775	c.2559C>A	c.(2557-2559)caC>caA	p.H853Q		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	853					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CAGAGTTGCACGTGAATGATG	0.502000													13	28					5.50884e-06	9.56422e-06	0.001368	1	0
PREX2	80243	broad.mit.edu	37	8	69002942	69002942	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:69002942C>A	ENST00000288368.4	+	20	2519	c.2242C>A	c.(2242-2244)Cca>Aca	p.P748T	RP11-403D15.2_ENST00000526901.1_RNA|PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	748	PDZ 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GTACAGGCGGCCAACGAAGGT	0.483000													11	45					3.86212e-05	6.52464e-05	0.000673	1	0
FBN3	84467	broad.mit.edu	37	19	8206823	8206823	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:8206823C>A	ENST00000600128.1	-	7	1154		c.e7+1		FBN3_ENST00000270509.2_Splice_Site|FBN3_ENST00000601739.1_Splice_Site			Q75N90	FBN3_HUMAN	fibrillin 3							proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CCACTATTCACCTTGGCAGGC	0.637000													12	48					1.08611e-07	1.98346e-07	0.000978	1	0
FUNDC2P2	388965	broad.mit.edu	37	2	84518274	84518274	+	RNA	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:84518274C>A	ENST00000331369.5	+	0	468																											CTGAAGATCCCTAAGAGCACT	0.458000													28	42					4.87955e-14	1.02762e-13	0.005443	1	0
SI	6476	broad.mit.edu	37	3	164741509	164741509	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:164741509T>A	ENST00000264382.3	-	26	3010	c.2948A>T	c.(2947-2949)tAt>tTt	p.Y983F		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	983	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTTGACTGAATAAGAGTTATC	0.403000										HNSCC(35;0.089)			10	47					0	0	0.000443	0	0
CASC1	55259	broad.mit.edu	37	12	25343548	25343548	+	Splice_Site	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:25343548C>G	ENST00000354189.5	-	2	230	c.195_splice	c.e2+1	p.K65_splice	CASC1_ENST00000557684.1_Intron|CASC1_ENST00000537577.1_Intron|CASC1_ENST00000395987.3_Splice_Site_p.K7_splice|CASC1_ENST00000395990.2_5'UTR|CASC1_ENST00000320267.9_Intron|CASC1_ENST00000545133.1_Intron	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	0	Glu-rich.									breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TTCTACATACCTTTTTTGCTT	0.234000													18	39					0	0	0.002299	0	0
DICER1	23405	broad.mit.edu	37	14	95582111	95582111	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95582111G>T	ENST00000526495.1	-	13	2091	c.1800C>A	c.(1798-1800)gaC>gaA	p.D600E	DICER1_ENST00000541352.1_Missense_Mutation_p.D600E|DICER1_ENST00000527414.1_Missense_Mutation_p.D600E|DICER1_ENST00000393063.1_Missense_Mutation_p.D600E|DICER1_ENST00000343455.3_Missense_Mutation_p.D600E			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	600	Helicase C-terminal.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CAGGATCAATGTCAGTCTCAC	0.433000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				24	44					2.39556e-15	5.20335e-15	0.002780	1	0
SGPP1	81537	broad.mit.edu	37	14	64152979	64152979	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:64152979T>A	ENST00000247225.6	-	3	1264	c.1170A>T	c.(1168-1170)ttA>ttT	p.L390F		NM_030791.2	NP_110418.1	Q9BX95	SGPP1_HUMAN	sphingosine-1-phosphate phosphatase 1	390						endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	10				OV - Ovarian serous cystadenocarcinoma(108;0.0056)|all cancers(60;0.0141)|BRCA - Breast invasive adenocarcinoma(234;0.103)		TTTTGCAGGCTAAAGGAATGG	0.373000													23	87					0	0	0.002780	0	0
GRHL2	79977	broad.mit.edu	37	8	102656369	102656369	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:102656369C>T	ENST00000251808.3	+	13	1866	c.1528C>T	c.(1528-1530)Ctt>Ttt	p.L510F	GRHL2_ENST00000395927.1_Missense_Mutation_p.L494F|GRHL2_ENST00000517674.1_3'UTR	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	510						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			TGGCAGTGTCCTTGTTAAACG	0.463000													8	22					0	0	0.004482	0	0
ZBTB7A	51341	broad.mit.edu	37	19	4054160	4054160	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:4054160G>T	ENST00000322357.4	-	2	1349	c.1071C>A	c.(1069-1071)agC>agA	p.S357R	ZBTB7A_ENST00000601588.1_Missense_Mutation_p.S357R	NM_015898.2	NP_056982.1	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	357					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTGGGCGCCGCTGAAGTACT	0.667000													20	44					7.41877e-09	1.39415e-08	0.001882	1	0
EPHA3	2042	broad.mit.edu	37	3	89391052	89391052	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:89391052G>T	ENST00000336596.2	+	5	1343	c.1118G>T	c.(1117-1119)tGt>tTt	p.C373F	EPHA3_ENST00000452448.2_Missense_Mutation_p.C373F|EPHA3_ENST00000494014.1_Missense_Mutation_p.C373F	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	373	Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATAAAACAGTGTGAGCCATGC	0.493000										TSP Lung(6;0.00050)			14	28					1.3612e-06	2.40699e-06	0.003163	1	0
TNKS2	80351	broad.mit.edu	37	10	93601155	93601155	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:93601155C>A	ENST00000371627.4	+	15	2168	c.1789C>A	c.(1789-1791)Cat>Aat	p.H597N		NM_025235.3	NP_079511.1	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	597					positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			biliary_tract(1)|breast(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	48		Colorectal(252;0.162)				TACACCTTTACATGAAGCAGC	0.323000													17	57					2.94398e-08	5.46584e-08	0.000958	1	0
CHEK2P2	646096	broad.mit.edu	37	15	20490575	20490575	+	RNA	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:20490575C>T	ENST00000555186.1	+	0	555					NR_038836.1																						AGCCTTAAGACACTGTGGCTT	0.473000													47	341					0	0	0.003610	0	0
SLIT2	9353	broad.mit.edu	37	4	20255599	20255599	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:20255599C>A	ENST00000504154.1	+	1	413	c.161C>A	c.(160-162)cCc>cAc	p.P54H	SLIT2_ENST00000503823.1_Missense_Mutation_p.P54H|SLIT2_ENST00000503837.1_Missense_Mutation_p.P54H|SLIT2_ENST00000273739.5_Missense_Mutation_p.P54H	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	54	LRRNT.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AGGAATATCCCCCGCAACACC	0.667000													20	65					9.95505e-16	2.18597e-15	0.002299	1	0
ALKBH2	121642	broad.mit.edu	37	12	109530453	109530453	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:109530453C>A	ENST00000429722.2	-	2	502	c.139G>T	c.(139-141)Ggg>Tgg	p.G47W	ALKBH2_ENST00000343075.3_Missense_Mutation_p.G47W|ALKBH2_ENST00000440112.2_Missense_Mutation_p.G47W	NM_001145374.1	NP_001138846.1	Q6NS38	ALKB2_HUMAN	alkB, alkylation repair homolog 2 (E. coli)	47					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(3)|large_intestine(1)|lung(3)	8					Vitamin C(DB00126)	CCTCCATTCCCTGGGGCCTCT	0.582000								Direct reversal of damage					50	115					1.00776e-21	2.42805e-21	0.003610	1	0
SLC35F4	341880	broad.mit.edu	37	14	58056150	58056150	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:58056150A>G	ENST00000556826.1	-	3	607	c.371T>C	c.(370-372)aTg>aCg	p.M124T	SLC35F4_ENST00000339762.6_Missense_Mutation_p.M160T|SLC35F4_ENST00000554729.1_Start_Codon_SNP_p.M1T	NM_001206920.1	NP_001193849.1			solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CTTCAGAACCATGGACGTGCA	0.443000													11	29					0	0	0.000673	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73315415	73315415	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:73315415G>A	ENST00000258098.6	-	3	1571	c.1331C>T	c.(1330-1332)tCt>tTt	p.S444F	RAB11FIP5_ENST00000493523.2_5'UTR	NM_015470.2	NP_056285.1	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	444					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding			biliary_tract(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	23						CACAGCCTCAGAGGAGGCCAC	0.657000													39	88					0	0	0.002222	0	0
KIF21B	23046	broad.mit.edu	37	1	200948800	200948800	+	Silent	SNP	G	G	T	rs144601295		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:200948800G>T	ENST00000332129.2	-	29	4300	c.3984C>A	c.(3982-3984)atC>atA	p.I1328I	KIF21B_ENST00000360529.5_Silent_p.I1328I|KIF21B_ENST00000461742.2_Silent_p.I1341I|KIF21B_ENST00000422435.2_Silent_p.I1341I	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1341					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TTAGAGCTGCGATCTCCTGTC	0.587000											OREG0014066	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	73	166					4.49761e-31	1.13259e-30	0.003610	1	0
CRNN	49860	broad.mit.edu	37	1	152382869	152382869	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:152382869G>T	ENST00000271835.3	-	3	751	c.689C>A	c.(688-690)tCt>tAt	p.S230Y	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	230	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGAGTTCCAGATCCAGTCAC	0.577000													98	211					4.7146e-34	1.19926e-33	0.003610	1	0
PCDH15	65217	broad.mit.edu	37	10	56106245	56106245	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:56106245C>A	ENST00000373965.2	-	6	869		c.e6-1		PCDH15_ENST00000361849.3_Splice_Site|PCDH15_ENST00000373955.1_Splice_Site|PCDH15_ENST00000395440.1_Splice_Site|PCDH15_ENST00000373957.3_Splice_Site|PCDH15_ENST00000395445.1_Splice_Site|PCDH15_ENST00000395433.1_Splice_Site|PCDH15_ENST00000414778.1_Splice_Site|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395432.2_Splice_Site|PCDH15_ENST00000395430.1_Splice_Site|PCDH15_ENST00000395438.1_Splice_Site|PCDH15_ENST00000320301.6_Splice_Site|PCDH15_ENST00000395442.1_Splice_Site|PCDH15_ENST00000437009.1_Splice_Site|PCDH15_ENST00000395446.1_Splice_Site	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15						equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CTGGAGTGAGCTGAAAGGAAA	0.338000										HNSCC(58;0.16)			34	89					2.26627e-22	5.49325e-22	0.001706	1	0
IRX6	79190	broad.mit.edu	37	16	55360356	55360356	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:55360356T>A	ENST00000290552.7	+	2	1486	c.154T>A	c.(154-156)Tac>Aac	p.Y52N	RP11-26L20.3_ENST00000558730.2_RNA|IRX6_ENST00000558315.1_3'UTR	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	52						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						CTGCGCACCCTACGATAGTCG	0.652000													15	15					0	0	0.002450	0	0
CSPG5	10675	broad.mit.edu	37	3	47618790	47618790	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:47618790C>T	ENST00000383738.2	-	2	2824	c.726G>A	c.(724-726)gaG>gaA	p.E242E	CSPG5_ENST00000264723.4_Silent_p.E242E|CSPG5_ENST00000456150.1_Silent_p.E104E	NM_001206943.1|NM_001206945.1	NP_001193872.1|NP_001193874.1	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan C)	242					cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	22				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GGGTCTCTCCCTCAGTATCAG	0.527000													9	12					0	0	0.004482	0	0
C7orf57	136288	broad.mit.edu	37	7	48080958	48080958	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:48080958G>T	ENST00000348904.3	+	3	295	c.83G>T	c.(82-84)cGc>cTc	p.R28L	C7orf57_ENST00000435376.1_5'UTR|C7orf57_ENST00000430738.1_Missense_Mutation_p.R73L|C7orf57_ENST00000539619.1_Missense_Mutation_p.R28L|C7orf57_ENST00000420324.1_Missense_Mutation_p.R73L	NM_001100159.2	NP_001093629.1	Q8NEG2	CG057_HUMAN	chromosome 7 open reading frame 57	28										breast(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	9						CCAGTGAAGCGCTCTGAGAAG	0.582000													10	43					2.80697e-09	5.32476e-09	0.000978	1	0
SEC1P	653677	broad.mit.edu	37	19	49183480	49183480	+	RNA	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:49183480G>A	ENST00000430145.2	+	0	567					NR_004401.2																						TCCAAGGGCCGCCTGGGGAAC	0.682000													3	5					0	0	0.004672	0	0
GLI2	2736	broad.mit.edu	37	2	121747847	121747847	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:121747847A>G	ENST00000452319.1	+	14	4417	c.4357A>G	c.(4357-4359)Atg>Gtg	p.M1453V	GLI2_ENST00000361492.4_Missense_Mutation_p.M1453V|GLI2_ENST00000314490.11_Intron			P10070	GLI2_HUMAN	GLI family zinc finger 2	1453					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CCAGATCCACATGTACGAACA	0.657000													24	64					0	0	0.005443	0	0
RIMS2	9699	broad.mit.edu	37	8	104898151	104898151	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:104898151C>G	ENST00000507740.1	+	2	984	c.748C>G	c.(748-750)Ccc>Gcc	p.P250A	RIMS2_ENST00000436393.2_Missense_Mutation_p.P220A|RIMS2_ENST00000262231.10_Missense_Mutation_p.P250A|RIMS2_ENST00000406091.3_Missense_Mutation_p.P442A	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	473					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAGTCCACTACCCATAGATAG	0.463000										HNSCC(12;0.0054)			10	44					0	0	0.000673	0	0
EPHB2	2048	broad.mit.edu	37	1	23234658	23234658	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:23234658C>A	ENST00000400191.3	+	12	2367	c.2349C>A	c.(2347-2349)gcC>gcA	p.A783A	EPHB2_ENST00000374627.1_Silent_p.A778A|EPHB2_ENST00000374630.3_Silent_p.A783A|EPHB2_ENST00000374632.3_Silent_p.A784A	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	783	Protein kinase.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		ACACCAGTGCCCTGGTAAGAT	0.552000													24	22					9.95505e-16	2.18597e-15	0.002299	1	0
PLSCR4	57088	broad.mit.edu	37	3	145938675	145938675	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:145938675T>G	ENST00000354952.2	-	3	285	c.45A>C	c.(43-45)gaA>gaC	p.E15D	PLSCR4_ENST00000383083.2_Missense_Mutation_p.E15D|PLSCR4_ENST00000433593.2_5'UTR|PLSCR4_ENST00000446574.2_Missense_Mutation_p.E15D|PLSCR4_ENST00000493382.1_Missense_Mutation_p.E15D	NM_020353.2	NP_065086.2	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4	15					blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			kidney(1)|large_intestine(6)|lung(9)|urinary_tract(1)	17						GATTTTCCATTTCACCTGCAG	0.393000													11	33					0	0	0.000978	0	0
RNF17	56163	broad.mit.edu	37	13	25406105	25406105	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:25406105G>T	ENST00000255324.5	+	18	2523	c.2471G>T	c.(2470-2472)tGt>tTt	p.C824F	RNF17_ENST00000381921.1_Missense_Mutation_p.C824F	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	824					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TTTATGACATGTTCAGTTATC	0.259000													6	12					0.00116845	0.00191591	0.001168	1	0
PASD1	139135	broad.mit.edu	37	X	150840977	150840977	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:150840977T>A	ENST00000370357.4	+	14	2005	c.1760T>A	c.(1759-1761)cTg>cAg	p.L587Q		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	587						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CAGATATGCCTGCAAAACCCA	0.522000													30	16					0	0	0.002096	0	0
DIDO1	11083	broad.mit.edu	37	20	61525097	61525097	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:61525097C>A	ENST00000266070.4	-	12	3347	c.3022G>T	c.(3022-3024)Gtg>Ttg	p.V1008L	DIDO1_ENST00000395340.1_Missense_Mutation_p.V1008L|DIDO1_ENST00000395343.1_Missense_Mutation_p.V1008L|DIDO1_ENST00000395335.2_Missense_Mutation_p.V1008L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1008					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GACTTGGGCACCATCACAGAA	0.557000													39	53					2.05212e-20	4.86832e-20	0.005524	1	0
PDILT	204474	broad.mit.edu	37	16	20370759	20370759	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:20370759G>C	ENST00000302451.4	-	12	1885	c.1637C>G	c.(1636-1638)tCc>tGc	p.S546C		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	546					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						TTCCAGCTTGGATACGTACTT	0.512000													50	245					0	0	0.003610	0	0
LRSAM1	90678	broad.mit.edu	37	9	130241717	130241717	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:130241717G>T	ENST00000323301.4	+	12	1440	c.836G>T	c.(835-837)cGg>cTg	p.R279L	LRSAM1_ENST00000373322.1_Missense_Mutation_p.R279L|LRSAM1_ENST00000483302.1_3'UTR|LRSAM1_ENST00000373324.4_Missense_Mutation_p.R279L|LRSAM1_ENST00000300417.6_Missense_Mutation_p.R279L	NM_138361.5	NP_612370.3	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif containing 1	279					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(2)	16						CTGGGGCAGCGGGAGCACACC	0.602000													29	32					7.01153e-11	1.38369e-10	0.001271	1	0
PRH1	5554	broad.mit.edu	37	12	11034876	11034876	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:11034876C>A	ENST00000428168.2	-	4	496	c.459G>T	c.(457-459)ggG>ggT	p.G153G	PRR4_ENST00000536668.1_5'UTR	NM_006250.3	NP_006241.2	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 1	153						extracellular space	protein binding			endometrium(1)|kidney(1)|lung(2)|upper_aerodigestive_tract(1)	5				BRCA - Breast invasive adenocarcinoma(232;0.245)		GTGGGCGGCCCCCTTGGGGAG	0.587000													32	107					4.75821e-42	1.22119e-41	0.003610	1	0
MYO1F	4542	broad.mit.edu	37	19	8587264	8587264	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:8587264C>T	ENST00000338257.8	-	27	3484	c.3217G>A	c.(3217-3219)Gaa>Aaa	p.E1073K		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	1073	SH3.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CACACACCTTCCATGAGGATC	0.592000													12	27					0	0	0.001368	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182402	140182402	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140182402G>T	ENST00000522353.2	+	1	1620	c.1620G>T	c.(1618-1620)gcG>gcT	p.A540A	PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000532566.2_Silent_p.A540A|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCGATGCGGGCGTGCCGC	0.672000													50	131					4.44712e-29	1.11428e-28	0.003610	1	0
SCN11A	11280	broad.mit.edu	37	3	38946691	38946691	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:38946691G>T	ENST00000450244.1	-	11	1793	c.1595C>A	c.(1594-1596)aCc>aAc	p.T532N	SCN11A_ENST00000456224.3_Missense_Mutation_p.T532N|SCN11A_ENST00000444237.2_Missense_Mutation_p.T532N|SCN11A_ENST00000302328.3_Missense_Mutation_p.T532N			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	532					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ACCCTTCATGGTGATGGTGAG	0.488000													57	58					6.176e-18	1.40535e-17	0.003610	1	0
PTK2B	2185	broad.mit.edu	37	8	27295006	27295006	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:27295006A>G	ENST00000397501.1	+	22	2328	c.1520A>G	c.(1519-1521)tAt>tGt	p.Y507C	PTK2B_ENST00000338238.4_Missense_Mutation_p.Y507C|PTK2B_ENST00000397497.4_Missense_Mutation_p.Y253C|PTK2B_ENST00000346049.5_Missense_Mutation_p.Y507C|PTK2B_ENST00000517339.1_Missense_Mutation_p.Y507C|PTK2B_ENST00000420218.2_Missense_Mutation_p.Y507C|PTK2B_ENST00000544172.1_Missense_Mutation_p.Y507C	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	507	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TTGTATCCCTATGGGGAGGTG	0.552000													12	29					0	0	0.000978	0	0
TMEM68	137695	broad.mit.edu	37	8	56675124	56675124	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:56675124T>C	ENST00000521229.1	-	3	607	c.395A>G	c.(394-396)cAt>cGt	p.H132R	TMEM68_ENST00000522576.1_Missense_Mutation_p.H132R|TMEM68_ENST00000523073.1_Intron|TMEM68_ENST00000334667.2_Intron|TMEM68_ENST00000434581.2_Intron|TMEM68_ENST00000519784.1_Intron			Q96MH6	TMM68_HUMAN	transmembrane protein 68	0						integral to membrane	acyltransferase activity			NS(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6			Epithelial(17;0.000361)|all cancers(17;0.00326)			atcaaTAAAATGGAATGGTAA	0.383000													15	30					0	0	0.002450	0	0
OR4A16	81327	broad.mit.edu	37	11	55110887	55110887	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55110887T>C	ENST00000314721.2	+	1	261	c.211T>C	c.(211-213)Tat>Cat	p.Y71H		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						GGATGCCATATATTCCACTGC	0.453000													44	111					0	0	0.002522	0	0
SLIT2	9353	broad.mit.edu	37	4	20568976	20568976	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:20568976C>T	ENST00000504154.1	+	27	3069	c.2817C>T	c.(2815-2817)gaC>gaT	p.D939D	SLIT2_ENST00000503823.1_Silent_p.D931D|SLIT2_ENST00000503837.1_Silent_p.D935D|SLIT2_ENST00000273739.5_Silent_p.D943D	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	939	EGF-like 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						ATCCAGTTGACTTTTACCGAT	0.383000													32	79					0	0	0.002096	0	0
SFI1	9814	broad.mit.edu	37	22	31946321	31946321	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:31946321A>T	ENST00000432498.1	+	6	924	c.531A>T	c.(529-531)agA>agT	p.R177S	SFI1_ENST00000414585.1_Intron|SFI1_ENST00000443011.1_Intron|SFI1_ENST00000443326.1_Missense_Mutation_p.R95S|SFI1_ENST00000400288.2_Missense_Mutation_p.R177S|SFI1_ENST00000540643.1_Missense_Mutation_p.R153S|SFI1_ENST00000400289.1_Missense_Mutation_p.R95S	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	177					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						AGTACATTAGAGCCGAGGTTC	0.448000													18	32					0	0	0.006122	0	0
ZBTB7A	51341	broad.mit.edu	37	19	4054266	4054266	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:4054266T>A	ENST00000322357.4	-	2	1243	c.965A>T	c.(964-966)cAg>cTg	p.Q322L	ZBTB7A_ENST00000601588.1_Missense_Mutation_p.Q322L	NM_015898.2	NP_056982.1	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	322					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		TGACATCATCTGCTGCAGCAG	0.731000													4	15					0	0	0.000248	0	0
KIF25	3834	broad.mit.edu	37	6	168434642	168434642	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:168434642G>A	ENST00000443060.2	+	5	639	c.248G>A	c.(247-249)gGc>gAc	p.G83D	KIF25_ENST00000354419.2_Missense_Mutation_p.G83D|KIF25_ENST00000351261.3_Missense_Mutation_p.G83D			Q9UIL4	KIF25_HUMAN	kinesin family member 25	83	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		TCGGACGACGGCCCTGTTCTG	0.527000													17	39					0	0	0.004007	0	0
TRAC	28755	broad.mit.edu	37	14	23021046	23021046	+	RNA	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:23021046C>G	ENST00000478163.3	+	0	923																											TGTGTCTGGGCGTGTTGTATG	0.428000													10	50					0	0	0.000978	0	0
PYDC2	152138	broad.mit.edu	37	3	191179206	191179206	+	Silent	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:191179206T>G	ENST00000518817.1	+	1	255	c.255T>G	c.(253-255)tcT>tcG	p.S85S		NM_001083308.1	NP_001076777.1	Q56P42	PYDC2_HUMAN	pyrin domain containing 2	85	DAPIN.					cytoplasm|nucleus				breast(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	10						CGCATCTGTCTGGGAGAGCTG	0.517000													30	180					0	0	0.002836	0	0
IL1RAP	3556	broad.mit.edu	37	3	190326880	190326880	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:190326880G>T	ENST00000412504.2	+	4	699	c.447G>T	c.(445-447)ctG>ctT	p.L149L	IL1RAP_ENST00000434491.1_Silent_p.L8L|IL1RAP_ENST00000422940.1_Silent_p.L149L|IL1RAP_ENST00000447382.1_Silent_p.L149L|IL1RAP_ENST00000439062.1_Silent_p.L149L|IL1RAP_ENST00000317757.3_Silent_p.L149L|IL1RAP_ENST00000072516.3_Silent_p.L149L|IL1RAP_ENST00000443369.2_Silent_p.L149L|IL1RAP_ENST00000422485.1_Silent_p.L149L			Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein	149	Ig-like C2-type 2.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		TGCATAAACTGTATATAGAAT	0.388000													26	115					1.42536e-11	2.85498e-11	0.004656	1	0
IGKV3-11	28914	broad.mit.edu	37	2	89326772	89326772	+	RNA	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:89326772T>C	ENST00000483158.1	-	0	287																											CCACTGAACCTGGCTGGGATG	0.537000													27	85					0	0	0.001061	0	0
LRRK2	120892	broad.mit.edu	37	12	40692113	40692113	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:40692113G>C	ENST00000298910.7	+	24	3223	c.3165G>C	c.(3163-3165)ttG>ttC	p.L1055F	LRRK2_ENST00000343742.2_Missense_Mutation_p.L1055F	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1055					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CTTATTTGTTGAAAATGAGTT	0.333000													15	41					0	0	0.003163	0	0
KRTAP13-3	337960	broad.mit.edu	37	21	31797760	31797760	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:31797760C>T	ENST00000390690.2	-	1	526	c.471G>A	c.(469-471)tgG>tgA	p.W157*		NM_181622.1	NP_853653.1	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	157						intermediate filament				endometrium(1)|large_intestine(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	14						ATGAATGGAACCACCTTCTAG	0.388000													19	28					0	0	0.006122	0	0
GPR98	84059	broad.mit.edu	37	5	89930999	89930999	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:89930999C>T	ENST00000405460.2	+	10	2004	c.1908C>T	c.(1906-1908)atC>atT	p.I636I		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	636					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTGGGGAAATCTGCAATATTT	0.358000													22	71					0	0	0.001523	0	0
TIMM44	10469	broad.mit.edu	37	19	7999066	7999066	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:7999066C>A	ENST00000270538.3	-	5	719	c.451G>T	c.(451-453)Gaa>Taa	p.E151*		NM_006351.3	NP_006342.2	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44 homolog (yeast)	151					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(2)|liver(2)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	17						TTGGCTGCTTCCTCCACGCCC	0.622000													32	103					9.93527e-08	1.82602e-07	0.002836	1	0
TRERF1	55809	broad.mit.edu	37	6	42236484	42236484	+	Missense_Mutation	SNP	C	C	A	rs147382652		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:42236484C>A	ENST00000541110.1	-	5	1413	c.845G>T	c.(844-846)cGt>cTt	p.R282L	TRERF1_ENST00000372917.4_Missense_Mutation_p.R282L|TRERF1_ENST00000354325.2_Missense_Mutation_p.R282L|TRERF1_ENST00000372922.4_Missense_Mutation_p.R282L|TRERF1_ENST00000340840.2_Missense_Mutation_p.R282L			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	282	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CATGGAGATACGCTGTTGCCC	0.597000													91	69					3.77759e-48	9.70758e-48	0.003610	1	0
COL6A1	1291	broad.mit.edu	37	21	47421935	47421935	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:47421935C>T	ENST00000361866.3	+	31	2131	c.2017C>T	c.(2017-2019)Cac>Tac	p.H673Y	COL6A1_ENST00000498614.1_3'UTR	NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	673	C-terminal globular domain.|VWFA 2.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GATGCAGGAGCACGTGAGCCT	0.697000													14	38					0	0	0.001855	0	0
MESP2	145873	broad.mit.edu	37	15	90320436	90320436	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:90320436C>G	ENST00000341735.3	+	1	848	c.848C>G	c.(847-849)tCg>tGg	p.S283W	MESP2_ENST00000560219.1_Intron|MESP2_ENST00000558723.1_Intron	NM_001039958.1	NP_001035047.1	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog (mouse)	283					Notch signaling pathway	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			TGGACGCAGTCGTCCCCAGAG	0.647000													10	7					0	0	0.000443	0	0
COL3A1	1281	broad.mit.edu	37	2	189854843	189854843	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:189854843C>A	ENST00000304636.3	+	9	882	c.712C>A	c.(712-714)Cga>Aga	p.R238R	COL3A1_ENST00000317840.5_Silent_p.R238R	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	238	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding	p.R238*(1)		NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TAGACCCGGACGACCTGGAGA	0.383000													13	23					0.00244969	0.00398423	0.002450	1	0
DST	667	broad.mit.edu	37	6	56347649	56347649	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:56347649C>A	ENST00000370754.5	-	89	21140	c.21141G>T	c.(21139-21141)agG>agT	p.R7047S	DST_ENST00000312431.6_3'UTR|DST_ENST00000446842.2_Missense_Mutation_p.R6543S|DST_ENST00000361203.3_Missense_Mutation_p.R6758S|DST_ENST00000244364.6_Missense_Mutation_p.R4455S|DST_ENST00000370788.2_Missense_Mutation_p.R4672S|DST_ENST00000421834.2_Missense_Mutation_p.R4781S|DST_ENST00000370769.4_Missense_Mutation_p.R6869S			Q03001	DYST_HUMAN	dystonin	6867					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CACTGCTGGTCCTCTTCCCCA	0.443000													21	77					5.45024e-15	1.18e-14	0.003330	1	0
POU1F1	5449	broad.mit.edu	37	3	87313582	87313582	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:87313582C>A	ENST00000350375.2	-	3	419	c.295G>T	c.(295-297)Gca>Tca	p.A99S	POU1F1_ENST00000560656.1_Missense_Mutation_p.A99S|POU1F1_ENST00000344265.3_Missense_Mutation_p.A125S	NM_000306.2	NP_000297.1	P28069	PIT1_HUMAN	POU class 1 homeobox 1	99					negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(2)	18	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		GGGTCCTCTGCCAGAAGAGGC	0.438000													39	36					6.2361e-21	1.48821e-20	0.001706	1	0
ACADL	33	broad.mit.edu	37	2	211085399	211085399	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:211085399G>T	ENST00000233710.3	-	2	432	c.205C>A	c.(205-207)Caa>Aaa	p.Q69K	AC006994.2_ENST00000412065.1_RNA	NM_001608.3	NP_001599.1	P28330	ACADL_HUMAN	acyl-CoA dehydrogenase, long chain	69					carnitine catabolic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial matrix	long-chain-acyl-CoA dehydrogenase activity|palmitoyl-CoA oxidase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	14		Renal(323;0.202)		Epithelial(149;0.00631)|Lung(261;0.0438)|LUSC - Lung squamous cell carcinoma(261;0.0466)|all cancers(144;0.0621)		ACTTCTTCTTGGAAAAACTTC	0.358000													18	23					1.00905e-13	2.10954e-13	0.001216	1	0
MAGEB10	139422	broad.mit.edu	37	X	27839501	27839501	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:27839501A>T	ENST00000356790.2	+	3	323	c.78A>T	c.(76-78)atA>atT	p.I26I		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	26										NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						AAGATTTGATAGATGCTCTGG	0.512000													18	20					0	0	0.006122	0	0
ABCC2	1244	broad.mit.edu	37	10	101544522	101544522	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:101544522T>A	ENST00000370449.4	+	2	304	c.191T>A	c.(190-192)cTc>cAc	p.L64H	ABCC2_ENST00000370434.1_Missense_Mutation_p.L64H	NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	64						apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ACCACCAAACTCTATCTTGCT	0.473000													28	55					0	0	0.001271	0	0
AMELY	266	broad.mit.edu	37	Y	6736363	6736363	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:6736363G>T	ENST00000215479.5	-	5	355	c.288C>A	c.(286-288)gtC>gtA	p.V96V	AMELY_ENST00000383036.1_Silent_p.V110V|AMELY_ENST00000383037.4_Silent_p.V110V	NM_001143.1	NP_001134.1	Q99218	AMELY_HUMAN	amelogenin, Y-linked	110	Gln-rich.				biomineral tissue development	proteinaceous extracellular matrix	structural constituent of tooth enamel			NS(1)|lung(5)	6						CTTGCTGGCGGACCCTGGGCT	0.612000													32	25					1.22384e-17	2.77855e-17	0.002836	1	0
ATP6V0D2	245972	broad.mit.edu	37	8	87165148	87165148	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:87165148C>A	ENST00000285393.3	+	8	1137	c.995C>A	c.(994-996)gCa>gAa	p.A332E	CTD-3118D11.2_ENST00000522679.1_RNA	NM_152565.1	NP_689778.1	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2	332					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|prostate(1)	27						GTGTGGATAGCAGAATGTATT	0.333000													15	40					1.49906e-05	2.56927e-05	0.002450	1	0
USH2A	7399	broad.mit.edu	37	1	215847664	215847664	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:215847664G>T	ENST00000366943.2	-	63	13975	c.13589C>A	c.(13588-13590)tCa>tAa	p.S4530*	USH2A_ENST00000307340.3_Nonsense_Mutation_p.S4530*			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4530	Fibronectin type-III 31.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGAGGGTGCTGAGGGGCTGGT	0.512000										HNSCC(13;0.011)			43	81					7.05121e-23	1.72163e-22	0.002522	1	0
TENM1	10178	broad.mit.edu	37	X	123805537	123805537	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:123805537T>A	ENST00000422452.2	-	6	1227	c.1164A>T	c.(1162-1164)aaA>aaT	p.K388N	TENM1_ENST00000371130.3_Missense_Mutation_p.K388N	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		CTGTACCTTTTTTCTCTGATT	0.373000													37	24					0	0	0.003271	0	0
POTEH	23784	broad.mit.edu	37	22	16279270	16279270	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:16279270T>C	ENST00000343518.6	-	4	1004	c.953A>G	c.(952-954)cAt>cGt	p.H318R		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	318										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TTTTTGCTCATGTACACCAAG	0.328000													28	418					0	0	0.002836	0	0
TRAV41	28640	broad.mit.edu	37	14	22789047	22789047	+	RNA	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:22789047T>A	ENST00000390468.1	+	0	260																											ACAATAAACATACAGGAAAAG	0.507000													11	26					0	0	0.000673	0	0
SLC14A2	8170	broad.mit.edu	37	18	43253684	43253684	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:43253684T>A	ENST00000255226.6	+	18	3230	c.2414T>A	c.(2413-2415)tTc>tAc	p.F805Y	RP11-116O18.3_ENST00000589510.1_RNA|SLC14A2_ENST00000586448.1_Missense_Mutation_p.F805Y|SLC14A2_ENST00000589658.1_Missense_Mutation_p.F282Y	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	805						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TCCATCTACTTCGGCCTGTGT	0.587000													41	32					0	0	0.001706	0	0
ZFP36L1	677	broad.mit.edu	37	14	69257126	69257126	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:69257126C>A	ENST00000439696.2	-	2	442	c.141G>T	c.(139-141)ggG>ggT	p.G47G	ZFP36L1_ENST00000336440.3_Silent_p.G47G|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	47					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GAGGGAAGCCCCCACCAGCAG	0.612000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	22					0.000274275	0.000453435	0.004482	1	0
ATP10B	23120	broad.mit.edu	37	5	160071164	160071164	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:160071164A>G	ENST00000327245.5	-	9	1695	c.849T>C	c.(847-849)gtT>gtC	p.V283V		NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	283					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGACAATGCCAACAGCCATCT	0.493000													15	63					0	0	0.003163	0	0
SORL1	6653	broad.mit.edu	37	11	121495940	121495940	+	Missense_Mutation	SNP	G	G	C	rs149393026	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:121495940G>C	ENST00000260197.7	+	46	6447	c.6318G>C	c.(6316-6318)caG>caC	p.Q2106H	SORL1_ENST00000532694.1_Missense_Mutation_p.Q952H|SORL1_ENST00000534286.1_Missense_Mutation_p.Q1016H|SORL1_ENST00000527934.1_Missense_Mutation_p.Q721H|SORL1_ENST00000525532.1_Missense_Mutation_p.Q1050H	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	2106	Fibronectin type-III 6.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TTGGCAACCAGATCTGTGGGG	0.468000													23	70					0	0	0.002780	0	0
SUSD3	203328	broad.mit.edu	37	9	95846964	95846964	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:95846964C>G	ENST00000375472.3	+	5	739	c.703C>G	c.(703-705)Ccc>Gcc	p.P235A	SUSD3_ENST00000375469.1_Missense_Mutation_p.P222A	NM_145006.2	NP_659443.1	Q96L08	SUSD3_HUMAN	sushi domain containing 3	235						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	13						CCCCAGACAGCCCCTGCCTGC	0.637000													52	157					0	0	0.003610	0	0
ARID1A	8289	broad.mit.edu	37	1	27089589	27089589	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:27089589C>T	ENST00000324856.7	+	8	2916	c.2545C>T	c.(2545-2547)Cct>Tct	p.P849S	ARID1A_ENST00000374152.2_Missense_Mutation_p.P466S|ARID1A_ENST00000457599.2_Missense_Mutation_p.P849S	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	849					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGGCATCCCACCTTATGGCAC	0.587000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								17	43					0	0	0.004007	0	0
PRSS3	5646	broad.mit.edu	37	9	33799064	33799064	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:33799064C>G	ENST00000361005.5	+	5	801	c.801C>G	c.(799-801)ctC>ctG	p.L267L	RP11-133O22.6_ENST00000454429.2_RNA|PRSS3_ENST00000379405.3_Silent_p.L210L|PRSS3_ENST00000342836.4_Silent_p.L224L|PRSS3_ENST00000429677.3_Silent_p.L203L|PRSS3_ENST00000495682.1_3'UTR	NM_007343.3	NP_031369.2	P35030	TRY3_HUMAN	protease, serine, 3	267	Peptidase S1.				digestion|endothelial cell migration|zymogen activation	extracellular space	calcium ion binding|protein binding|serine-type endopeptidase activity|serine-type peptidase activity			large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	13			LUSC - Lung squamous cell carcinoma(29;0.0176)			ACGGACAGCTCCAAGGAGTTG	0.522000													34	100					0	0	0.003271	0	0
PCF11	51585	broad.mit.edu	37	11	82880066	82880066	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:82880066C>T	ENST00000298281.4	+	8	3141	c.2689C>T	c.(2689-2691)Cag>Tag	p.Q897*		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	897	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						ACCTCATGGTCAGCCTGTGGG	0.552000													20	38					0	0	0.000958	0	0
PRDM16	63976	broad.mit.edu	37	1	3319429	3319429	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:3319429T>G	ENST00000378398.3	+	7	836	c.754T>G	c.(754-756)Tac>Gac	p.Y252D	PRDM16_ENST00000442529.2_Missense_Mutation_p.Y251D|PRDM16_ENST00000441472.2_Missense_Mutation_p.Y251D|PRDM16_ENST00000514189.1_Missense_Mutation_p.Y252D|PRDM16_ENST00000511072.1_Missense_Mutation_p.Y252D|PRDM16_ENST00000378391.2_Missense_Mutation_p.Y251D|PRDM16_ENST00000270722.5_Missense_Mutation_p.Y251D|PRDM16_ENST00000512462.1_3'UTR			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	251					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CCATAAGAAGTACACGTGTGG	0.637000			T	EVI1	"""MDS, AML"""								49	33					0	0	0.003214	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75558105	75558105	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:75558105C>A	ENST00000604729.1	+	20	4367	c.4070C>A	c.(4069-4071)tCc>tAc	p.S1357Y	ZSWIM8_ENST00000604524.1_Missense_Mutation_p.S1352Y|ZSWIM8_ENST00000603114.1_Missense_Mutation_p.S1319Y|ZSWIM8_ENST00000398706.2_Missense_Mutation_p.S1357Y|ZSWIM8_ENST00000605216.1_Missense_Mutation_p.S1352Y|NDST2_ENST00000456638.1_Intron					zinc finger, SWIM-type containing 8																		GCAAGAGACTCCAATATGGTG	0.617000													20	57					8.00594e-06	1.38876e-05	0.000958	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28338577	28338577	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:28338577C>T	ENST00000284987.5	-	1	255	c.134G>A	c.(133-135)cGg>cAg	p.R45Q		NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	45					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						CCCCTGCCGCCGGCGGGGCTG	0.766000													7	13					0	0	0.003080	0	0
OR8H3	390152	broad.mit.edu	37	11	55890212	55890212	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55890212C>G	ENST00000313472.3	+	1	364	c.364C>G	c.(364-366)Cgc>Ggc	p.R122G		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					GGCCTATGATCGCTATGCAGC	0.463000													56	159					0	0	0.003610	0	0
LRP2	4036	broad.mit.edu	37	2	170096254	170096254	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:170096254A>T	ENST00000263816.3	-	26	4362	c.4077T>A	c.(4075-4077)ggT>ggA	p.G1359G		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1359	EGF-like 5.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CGTGAGTACAACCACCATTGA	0.383000													17	27					0	0	0.001216	0	0
HNRNPU	3192	broad.mit.edu	37	1	245018845	245018845	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:245018845C>G	ENST00000444376.2	-	12	2410	c.2176G>C	c.(2176-2178)Gga>Cga	p.G726R	HNRNPU_ENST00000283179.9_Missense_Mutation_p.G745R	NM_004501.3|NM_031844.2	NP_004492.2|NP_114032.2	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	745	Gly-rich.|RNA-binding RGG-box.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			CCACCACTTCCTCCACCGCCA	0.507000													30	110					0	0	0.001271	0	0
DCHS2	54798	broad.mit.edu	37	4	155163899	155163899	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:155163899C>A	ENST00000357232.3	-	22	5601	c.5602G>T	c.(5602-5604)Ggg>Tgg	p.G1868W		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1868	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CTGGGCATCCCTTTATCTGTG	0.383000													14	28					1.5739e-10	3.08478e-10	0.004007	1	0
ZNF705B	100132396	broad.mit.edu	37	8	7806692	7806692	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:7806692G>A	ENST00000443676.1	+	3	170	c.54G>A	c.(52-54)caG>caA	p.Q18Q	ZNF705B_ENST00000400120.3_Silent_p.Q18Q			P0CI00	Z705L_HUMAN	zinc finger protein 705B	18	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			kidney(2)|lung(2)	4						ACTTCACCCAGGAAGAGTGGG	0.428000													44	45					0	0	0.003610	0	0
OR5M3	219482	broad.mit.edu	37	11	56237806	56237806	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56237806G>T	ENST00000312240.2	-	1	208	c.168C>A	c.(166-168)ccC>ccA	p.P56P		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	56					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					AAAAGTACATGGGGTTGTTAA	0.393000													18	44					1.33834e-09	2.57284e-09	0.000958	1	0
ARHGAP35	2909	broad.mit.edu	37	19	47503715	47503715	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:47503715A>G	ENST00000404338.3	+	6	4270	c.4270A>G	c.(4270-4272)Atc>Gtc	p.I1424V		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	1424	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										CTACCAGACAATCATTGAACT	0.592000													60	146					0	0	0.003610	0	0
CEACAM7	1087	broad.mit.edu	37	19	42190981	42190981	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:42190981A>T	ENST00000006724.3	-	2	437	c.236T>A	c.(235-237)aTt>aAt	p.I79N	CEACAM7_ENST00000401731.1_Missense_Mutation_p.I79N|CEACAM7_ENST00000599715.1_5'UTR|CEACAM7_ENST00000602225.1_Missense_Mutation_p.I79N|CEACAM7_ENST00000338196.4_Missense_Mutation_p.I79N	NM_006890.3	NP_008821.1	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 7	79	Ig-like V-type.					anchored to membrane|integral to membrane|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		ATATCCTATAATTCGATAGTT	0.458000													46	116					0	0	0.003610	0	0
FLT3	2322	broad.mit.edu	37	13	28592684	28592684	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:28592684G>C	ENST00000380982.4	-	20	2542	c.2461C>G	c.(2461-2463)Cac>Gac	p.H821D	FLT3_ENST00000241453.7_Missense_Mutation_p.H821D|FLT3_ENST00000537084.1_Intron			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	821	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	ACTTTCCCGTGGGTGACAAGC	0.468000			"""Mis, O"""		"""AML, ALL"""								19	32					0	0	0.000958	0	0
APOBEC3B	9582	broad.mit.edu	37	22	39380220	39380220	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:39380220G>T	ENST00000402182.3	+	2	213	c.158G>T	c.(157-159)gGg>gTg	p.G53V	APOBEC3B_ENST00000333467.3_Missense_Mutation_p.G53V|APOBEC3B_ENST00000407298.3_Missense_Mutation_p.G53V			Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	53					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	13	Melanoma(58;0.04)					TGGGACACAGGGGTCTTTCGA	0.493000													23	7					7.87624e-14	1.65525e-13	0.002780	1	0
DNAH3	55567	broad.mit.edu	37	16	20948070	20948070	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:20948070C>T	ENST00000261383.3	-	60	11759	c.11760G>A	c.(11758-11760)gtG>gtA	p.V3920V	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3920					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GCACTTTACCCACAAGCATGC	0.572000													7	17					0	0	0.004482	0	0
POLE	5426	broad.mit.edu	37	12	133225973	133225973	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133225973C>A	ENST00000320574.5	-	31	3967	c.3924G>T	c.(3922-3924)cgG>cgT	p.R1308R	POLE_ENST00000535270.1_Silent_p.R1281R	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1308					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CAGGACCATCCCGGATGGCCC	0.647000								DNA polymerases (catalytic subunits)					17	50					9.16793e-09	1.72124e-08	0.004990	1	0
DOCK2	1794	broad.mit.edu	37	5	169188524	169188524	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:169188524C>A	ENST00000256935.8	+	25	2529	c.2447_splice	c.e25-1	p.Q817_splice	DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Splice_Site_p.Q309_splice|DOCK2_ENST00000540750.1_5'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	817					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGCCCTCAGCCAACTCCTGTA	0.483000													38	117					5.59293e-11	1.10591e-10	0.001485	1	0
KCNMA1	3778	broad.mit.edu	37	10	78846339	78846339	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:78846339G>T	ENST00000286627.5	-	11	2299	c.1347C>A	c.(1345-1347)aaC>aaA	p.N449K	KCNMA1_ENST00000372443.1_Missense_Mutation_p.N449K|KCNMA1_ENST00000404771.3_Missense_Mutation_p.N449K|KCNMA1_ENST00000404857.1_Missense_Mutation_p.N449K|KCNMA1_ENST00000406533.3_Missense_Mutation_p.N449K|KCNMA1_ENST00000354353.5_Missense_Mutation_p.N449K|KCNMA1_ENST00000372440.1_Missense_Mutation_p.N449K|KCNMA1_ENST00000286628.8_Missense_Mutation_p.N449K	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	449	RCK N-terminal.			N -> D (in Ref. 12; AAD31173).	cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CAAGCTCCAGGTTGGGGGAGA	0.468000													16	26					8.60227e-14	1.80594e-13	0.004007	1	0
PTPRN2	5799	broad.mit.edu	37	7	157364177	157364177	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:157364177T>C	ENST00000389413.3	-	19	2808	c.2705A>G	c.(2704-2706)aAc>aGc	p.N902S	PTPRN2_ENST00000409483.1_Missense_Mutation_p.N893S|PTPRN2_ENST00000389416.4_Missense_Mutation_p.N914S|PTPRN2_ENST00000404321.2_Missense_Mutation_p.N954S|PTPRN2_ENST00000389418.4_Missense_Mutation_p.N931S	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	931	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GTAGCACTTGTTTACTTTTCT	0.338000													21	63					0	0	0.002299	0	0
GPR133	283383	broad.mit.edu	37	12	131466553	131466553	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:131466553G>A	ENST00000261654.5	+	5	994	c.435G>A	c.(433-435)gtG>gtA	p.V145V	GPR133_ENST00000535015.1_Silent_p.V177V	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	145					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GAGGCTCTGTGGAGCTGTATA	0.587000													38	71					0	0	0.005524	0	0
OR2T11	127077	broad.mit.edu	37	1	248790227	248790227	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248790227G>C	ENST00000330803.2	-	1	264	c.203C>G	c.(202-204)aCc>aGc	p.T68S		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATGAAAAGGGTGTCCATGAT	0.483000													41	57					0	0	0.002222	0	0
TTC40	54777	broad.mit.edu	37	10	134660493	134660493	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:134660493C>T	ENST00000368586.5	-	43	6310	c.6210G>A	c.(6208-6210)gtG>gtA	p.V2070V	TTC40_ENST00000263170.5_Silent_p.V231V	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	231										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						CGACACACTCCACCATCTCCA	0.642000													7	16					0	0	0.001984	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140346602	140346602	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140346602C>A	ENST00000289269.5	+	1	783	c.251C>A	c.(250-252)gCg>gAg	p.A84E	PCDHA12_ENST00000398631.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		84	Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCTGGGTGCGCCCAGTCCG	0.697000													11	28					4.3838e-07	7.88377e-07	0.001855	1	0
CYB5RL	606495	broad.mit.edu	37	1	54645006	54645006	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:54645006A>T	ENST00000419823.2	-	6	784	c.560T>A	c.(559-561)cTg>cAg	p.L187Q	CYB5RL_ENST00000542737.1_Missense_Mutation_p.L187Q|CYB5RL_ENST00000537208.1_Intron|CYB5RL_ENST00000287899.8_Intron|CYB5RL_ENST00000534324.1_Missense_Mutation_p.L187Q|CYB5RL_ENST00000401046.3_Missense_Mutation_p.L39Q|RP11-446E24.4_ENST00000311841.7_Intron	NM_001031672.2	NP_001026842.2	Q6IPT4	NB5R5_HUMAN	cytochrome b5 reductase-like	187							cytochrome-b5 reductase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|urinary_tract(1)	8						GCCCGCAGCCAGCAAGAGGAG	0.542000													9	12					0	0	0.000443	0	0
EPHA6	285220	broad.mit.edu	37	3	97454962	97454962	+	Splice_Site	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:97454962T>C	ENST00000389672.5	+	16	3166	c.3128_splice	c.e16+1	p.V1043_splice		NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	948						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						GACATCCTTGTGTAAGAGGCA	0.383000													44	35					0	0	0.001951	0	0
PTPRD	5789	broad.mit.edu	37	9	8460478	8460478	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:8460478C>G	ENST00000381196.4	-	30	4351	c.3808G>C	c.(3808-3810)Gtt>Ctt	p.V1270L	PTPRD_ENST00000486161.1_Missense_Mutation_p.V859L|PTPRD_ENST00000358503.5_Missense_Mutation_p.V1248L|PTPRD_ENST00000356435.5_Missense_Mutation_p.V1270L|PTPRD_ENST00000397611.3_Missense_Mutation_p.V856L|PTPRD_ENST00000355233.5_Missense_Mutation_p.V859L|PTPRD_ENST00000537002.1_Missense_Mutation_p.V856L|PTPRD_ENST00000360074.4_Missense_Mutation_p.V1257L|PTPRD_ENST00000540109.1_Missense_Mutation_p.V1270L|PTPRD_ENST00000397606.3_Missense_Mutation_p.V849L|PTPRD_ENST00000397617.3_Missense_Mutation_p.V849L	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1270					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGACCTACAACCCAGATCAAG	0.448000										TSP Lung(15;0.13)			19	51					0	0	0.001216	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18435606	18435606	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:18435606T>C	ENST00000433979.1	+	2	707	c.591T>C	c.(589-591)caT>caC	p.H197H	RERGL_ENST00000541632.1_Intron|PIK3C2G_ENST00000266497.5_Silent_p.H197H|PIK3C2G_ENST00000535651.1_Silent_p.H197H|PIK3C2G_ENST00000538779.1_Silent_p.H197H	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	197					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				GGAGTGGACATGTGAACATTG	0.383000													48	130					0	0	0.003610	0	0
ZNF655	79027	broad.mit.edu	37	7	99170651	99170651	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:99170651G>C	ENST00000424881.1	+	4	1245	c.1025G>C	c.(1024-1026)aGt>aCt	p.S342T	ZNF655_ENST00000419215.2_3'UTR|ZNF655_ENST00000394163.2_Missense_Mutation_p.S307T|ZNF655_ENST00000252713.4_Missense_Mutation_p.S307T|ZNF655_ENST00000425063.1_3'UTR|ZNF655_ENST00000493277.1_Missense_Mutation_p.S342T	NM_001083956.1|NM_001085368.1	NP_001077425.1|NP_001078837.1	Q8N720	ZN655_HUMAN	zinc finger protein 655	307					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	16	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					AAATGTAGCAGTTGTGAAAGA	0.413000													20	52					0	0	0.001216	0	0
CTNNA2	1496	broad.mit.edu	37	2	80816527	80816527	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:80816527C>G	ENST00000466387.1	+	19	2830	c.2106C>G	c.(2104-2106)gcC>gcG	p.A702A	CTNNA2_ENST00000402739.4_Silent_p.A702A|CTNNA2_ENST00000343114.3_Silent_p.A381A|AC008067.2_ENST00000595478.1_RNA|AC008067.2_ENST00000596887.1_RNA|CTNNA2_ENST00000540488.1_Silent_p.A702A|CTNNA2_ENST00000496558.1_Silent_p.A702A|CTNNA2_ENST00000361291.4_Silent_p.A736A|CTNNA2_ENST00000541047.1_Silent_p.A702A|AC008067.2_ENST00000430876.1_RNA			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	702					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CAGAAGTGGCCAAATGGGACG	0.498000													35	57					0	0	0.003271	0	0
OR2F1	26211	broad.mit.edu	37	7	143657134	143657134	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:143657134G>T	ENST00000392899.1	+	1	108	c.71G>T	c.(70-72)cGg>cTg	p.R24L		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R24L(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					TGGGACACTCGGGTCTCCCTG	0.473000													80	142					1.45978e-39	3.73696e-39	0.003610	1	0
DOCK2	1794	broad.mit.edu	37	5	169454881	169454881	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:169454881C>T	ENST00000256935.8	+	34	3476	c.3396C>T	c.(3394-3396)atC>atT	p.I1132I	DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Silent_p.I624I|DOCK2_ENST00000540750.1_Silent_p.I193I	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1132	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAAACGAAATCATCCTGAAGC	0.448000													26	63					0	0	0.001271	0	0
NRG3	10718	broad.mit.edu	37	10	84745231	84745231	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:84745231G>C	ENST00000372142.2	+	11	1644	c.1370G>C	c.(1369-1371)aGc>aCc	p.S457T	NRG3_ENST00000537893.1_Missense_Mutation_p.S304T|NRG3_ENST00000404547.1_Missense_Mutation_p.S678T|NRG3_ENST00000372141.2_Missense_Mutation_p.S654T|NRG3_ENST00000556918.1_Missense_Mutation_p.S484T|NRG3_ENST00000545131.1_Missense_Mutation_p.S304T|NRG3_ENST00000404576.2_Missense_Mutation_p.S458T	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	678					regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GAACTGGCCAGCGTAGAAACC	0.473000													17	26					0	0	0.006122	0	0
HERC5	51191	broad.mit.edu	37	4	89407377	89407377	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:89407377G>T	ENST00000264350.3	+	14	2002	c.1849G>T	c.(1849-1851)Gtg>Ttg	p.V617L	HERC5_ENST00000508159.1_Missense_Mutation_p.V255L	NM_016323.3	NP_057407.2	Q9UII4	HERC5_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 5	617					innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			NS(2)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|liver(2)|lung(17)|ovary(4)|prostate(1)|skin(4)	53		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		GAAAATGACTGTGGTAGGTAT	0.373000													12	32					3.07112e-06	5.37379e-06	0.000978	1	0
DCC	1630	broad.mit.edu	37	18	51013297	51013297	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:51013297G>T	ENST00000442544.2	+	26	4483	c.3867G>T	c.(3865-3867)gtG>gtT	p.V1289V	DCC_ENST00000581580.1_Silent_p.V924V|RP11-671P2.1_ENST00000582064.1_RNA	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1289					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CACTCTCAGTGGACCGAGGTT	0.473000													42	35					2.26627e-22	5.49325e-22	0.001706	1	0
PON1	5444	broad.mit.edu	37	7	94944746	94944746	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:94944746A>G	ENST00000222381.3	-	4	489	c.258T>C	c.(256-258)ctT>ctC	p.L86L	PON1_ENST00000542556.1_Silent_p.L86L	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	86					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	GGTCCATCAGAAGTATTTTTC	0.388000													20	55					0	0	0.001523	0	0
CHGB	1114	broad.mit.edu	37	20	5903868	5903868	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:5903868G>A	ENST00000378961.4	+	4	1282	c.1078G>A	c.(1078-1080)Gag>Aag	p.E360K		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	360						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						CCTGGAGTGGGAGCGCTATAG	0.527000													33	94					0	0	0.002836	0	0
DDR1	780	broad.mit.edu	37	6	30860151	30860151	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:30860151A>G	ENST00000324771.8	+	10	1479	c.931A>G	c.(931-933)Atg>Gtg	p.M311V	DDR1_ENST00000508312.1_Missense_Mutation_p.M329V|DDR1_ENST00000418800.2_Missense_Mutation_p.M311V|DDR1_ENST00000376569.3_Missense_Mutation_p.M311V|DDR1_ENST00000376567.2_Missense_Mutation_p.M311V|DDR1_ENST00000454612.2_Missense_Mutation_p.M311V|DDR1_ENST00000376575.3_Missense_Mutation_p.M311V|DDR1_ENST00000452441.1_Missense_Mutation_p.M311V|DDR1_ENST00000361741.4_Missense_Mutation_p.M42V|DDR1_ENST00000376568.3_Missense_Mutation_p.M311V|DDR1_ENST00000513240.1_Missense_Mutation_p.M311V|DDR1_ENST00000446312.1_3'UTR|DDR1_ENST00000376570.4_Missense_Mutation_p.M311V			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	311					cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	TGGCCCTGCCATGGCCTGGGA	0.697000													31	36					0	0	0.001786	0	0
FGA	2243	broad.mit.edu	37	4	155505381	155505381	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:155505381G>C	ENST00000302053.3	-	6	2574	c.2496C>G	c.(2494-2496)aaC>aaG	p.N832K		NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	832	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CATAAGGACTGTTATTCCTTG	0.498000													34	100					0	0	0.003271	0	0
FAM155A	728215	broad.mit.edu	37	13	108518793	108518793	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:108518793A>G	ENST00000375915.2	-	1	290	c.152T>C	c.(151-153)cTg>cCg	p.L51P		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	51						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						ATCAGAGAGCAGGACTGTGAA	0.597000													40	81					0	0	0.005524	0	0
CCBL2	56267	broad.mit.edu	37	1	89430571	89430571	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:89430571C>A	ENST00000260508.4	-	5	731	c.394G>T	c.(394-396)Gta>Tta	p.V132L	CCBL2_ENST00000370485.2_Missense_Mutation_p.V132L|CCBL2_ENST00000446900.2_5'UTR|CCBL2_ENST00000370491.3_Missense_Mutation_p.V98L	NM_001008661.2	NP_001008661.1	Q6YP21	KAT3_HUMAN	cysteine conjugate-beta lyase 2	132					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			endometrium(3)|kidney(4)|large_intestine(2)|lung(4)|ovary(2)|skin(2)|soft_tissue(1)	18		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TATGCTCCTACTGTCACAAGG	0.333000													26	24					7.07758e-08	1.30199e-07	0.004656	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885723	88885723	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:88885723G>T	ENST00000319675.3	-	1	573	c.477C>A	c.(475-477)ctC>ctA	p.L159L		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	159								p.L159L(1)		breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						GCGACGCTGGGAGCAGCACGG	0.562000													26	61					1.37878e-21	3.318e-21	0.003330	1	0
ZNF107	51427	broad.mit.edu	37	7	64166767	64166767	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:64166767G>T	ENST00000395391.1	+	4	1460	c.85G>T	c.(85-87)Gtg>Ttg	p.V29L	ZNF107_ENST00000423627.1_Missense_Mutation_p.V29L|ZNF107_ENST00000344930.3_Missense_Mutation_p.V29L			Q9UII5	ZN107_HUMAN	zinc finger protein 107	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				TTTCCAGAAAGTGACACTGAG	0.358000													14	17					1.5842e-08	2.96042e-08	0.001855	1	0
GSTM4	2948	broad.mit.edu	37	1	110203833	110203833	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:110203833C>G	ENST00000369836.4	+	8	923	c.614C>G	c.(613-615)cCa>cGa	p.P205R	GSTM4_ENST00000369833.1_3'UTR|GSTM4_ENST00000336075.5_Missense_Mutation_p.P144R|GSTM4_ENST00000326729.5_Intron|GSTM4_ENST00000495742.1_3'UTR	NM_000850.4	NP_000841.1	Q03013	GSTM4_HUMAN	glutathione S-transferase mu 4	205	GST C-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	12		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0123)|Colorectal(144;0.0129)|Epithelial(280;0.0147)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.0471)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	CGCTTCCTCCCAAAACCTCTG	0.577000													16	164					0	0	0.004990	0	0
PKHD1	5314	broad.mit.edu	37	6	51947209	51947209	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:51947209C>T	ENST00000371117.3	-	4	537	c.262G>A	c.(262-264)Gtg>Atg	p.V88M	PKHD1_ENST00000340994.4_Missense_Mutation_p.V88M	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	88	IPT/TIG 1; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CATGTCACCACAGGCAAATCC	0.488000													173	135					0	0	0.003610	0	0
LIX1L	128077	broad.mit.edu	37	1	145497393	145497393	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:145497393G>T	ENST00000369308.3	+	4	672	c.597_splice	c.e4-1	p.G200_splice	RP11-315I20.1_ENST00000600340.1_RNA|RP11-315I20.1_ENST00000599626.1_RNA|RP11-315I20.1_ENST00000599469.1_RNA|RP11-315I20.1_ENST00000599147.1_RNA|RP11-315I20.1_ENST00000598354.1_RNA|RP11-315I20.1_ENST00000598103.1_RNA|RP11-315I20.1_ENST00000597144.1_RNA|RP11-315I20.1_ENST00000437797.1_RNA|RP11-315I20.1_ENST00000421764.1_RNA|RP11-315I20.1_ENST00000412239.1_RNA|RP11-315I20.1_ENST00000595494.1_RNA|RP11-315I20.1_ENST00000595518.1_RNA|RP11-315I20.1_ENST00000601726.1_RNA|RP11-315I20.1_ENST00000448561.1_RNA	NM_153713.1	NP_714924.1	Q8IVB5	LIX1L_HUMAN	Lix1 homolog (mouse)-like	200										large_intestine(4)|lung(6)|ovary(2)|skin(1)	13	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTACTACCAGGGCAACAGGGA	0.428000													10	41					0.000978159	0.00160783	0.000978	1	0
DCLRE1A	9937	broad.mit.edu	37	10	115608754	115608754	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:115608754A>G	ENST00000361384.2	-	2	3027	c.2110T>C	c.(2110-2112)Tat>Cat	p.Y704H	DCLRE1A_ENST00000369305.1_Missense_Mutation_p.Y704H	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	704					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		ATTTTCTTATAGAATGGACAT	0.378000								Other identified genes with known or suspected DNA repair function					67	136					0	0	0.003610	0	0
MC5R	4161	broad.mit.edu	37	18	13826509	13826509	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:13826509G>A	ENST00000324750.3	+	1	967	c.745G>A	c.(745-747)Gtg>Atg	p.V249M		NM_005913.2	NP_005904.1	P33032	MC5R_HUMAN	melanocortin 5 receptor	249					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						CGTGTTTACCGTGTGCTGGGC	0.587000													50	417					0	0	0.003610	0	0
XRN1	54464	broad.mit.edu	37	3	142030457	142030457	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:142030457G>C	ENST00000264951.4	-	42	5134	c.5017C>G	c.(5017-5019)Caa>Gaa	p.Q1673E	XRN1_ENST00000392981.2_Missense_Mutation_p.Q1661E	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	1673					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						CTATGGCCTTGAGAGGCAGTT	0.403000													30	170					0	0	0.001512	0	0
C3	718	broad.mit.edu	37	19	6686804	6686804	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:6686804C>G	ENST00000245907.6	-	28	3691	c.3599G>C	c.(3598-3600)gGc>gCc	p.G1200A		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1200					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTTCAGCCTGCCCATCTGGGC	0.542000													71	163					0	0	0.003610	0	0
PAX5	5079	broad.mit.edu	37	9	36846845	36846845	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:36846845A>T	ENST00000358127.4	-	9	1168	c.1094T>A	c.(1093-1095)cTg>cAg	p.L365Q	PAX5_ENST00000414447.1_Missense_Mutation_p.L322Q|PAX5_ENST00000377847.2_Intron|PAX5_ENST00000523145.1_Intron|PAX5_ENST00000377852.2_Missense_Mutation_p.L331Q|PAX5_ENST00000377853.2_Intron|PAX5_ENST00000520154.1_Intron|PAX5_ENST00000520281.1_Intron|PAX5_ENST00000523241.1_Missense_Mutation_p.C288S|PAX5_ENST00000522003.1_Missense_Mutation_p.L257Q|PAX5_ENST00000446742.1_Missense_Mutation_p.L265Q	NM_016734.1	NP_057953.1	Q02548	PAX5_HUMAN	paired box 5	365					cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(11)	PAX5/JAK2(18)	NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(151)|kidney(1)|lung(10)|prostate(1)|skin(1)	171		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		CTCACCAAGCAGCCCCGGGTT	0.632000			"""T, Mis, D, F, S"""	"""IGH@, ETV6, PML, FOXP1, ZNF521, ELN"""	"""NHL, ALL, B-ALL"""								9	23					0	0	0.000443	0	0
TMED6	146456	broad.mit.edu	37	16	69377541	69377541	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:69377541G>A	ENST00000288025.3	-	4	547	c.492C>T	c.(490-492)gaC>gaT	p.D164D	RP11-343C2.9_ENST00000563634.1_Intron|RP11-343C2.7_ENST00000564737.1_Intron	NM_144676.3	NP_653277.2	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain containing 6	164					transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|kidney(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	9						TTTGTGTGCCGTCCTATGAGA	0.428000													30	29					0	0	0.002096	0	0
SYT3	84258	broad.mit.edu	37	19	51133373	51133373	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:51133373G>T	ENST00000338916.4	-	3	1363	c.730C>A	c.(730-732)Ccc>Acc	p.P244T	SYT3_ENST00000600079.1_Missense_Mutation_p.P244T|SYT3_ENST00000544769.1_Missense_Mutation_p.P244T|SYT3_ENST00000593901.1_Missense_Mutation_p.P244T	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	244						cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		TCACTGCTGGGGTCCGGCTGG	0.642000													9	25					2.17888e-05	3.71854e-05	0.000443	1	0
BOD1L1	259282	broad.mit.edu	37	4	13605783	13605783	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:13605783G>T	ENST00000040738.5	-	10	2876	c.2741C>A	c.(2740-2742)tCa>tAa	p.S914*		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	914	Lys-rich.						DNA binding										TTGAGTTTTTGATTTAGACTT	0.383000													34	103					4.3181e-19	1.01007e-18	0.002836	1	0
TNS3	64759	broad.mit.edu	37	7	47408665	47408665	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:47408665G>T	ENST00000398879.1	-	17	1944	c.1578C>A	c.(1576-1578)ggC>ggA	p.G526G	TNS3_ENST00000311160.9_Silent_p.G526G|TNS3_ENST00000355730.3_Silent_p.G286G			Q68CZ2	TENS3_HUMAN	tensin 3	526						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						CAACGTTGCTGCCAAAACCGT	0.627000													21	30					1.2644e-06	2.24596e-06	0.001523	1	0
NR0B1	190	broad.mit.edu	37	X	30326348	30326348	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:30326348T>G	ENST00000378970.4	-	1	1367	c.1133A>C	c.(1132-1134)tAc>tCc	p.Y378S	NR0B1_ENST00000378963.1_Missense_Mutation_p.Y83S|NR0B1_ENST00000453287.1_Missense_Mutation_p.Y378S	NM_000475.4	NP_000466.2	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	378	Ligand-binding (By similarity).				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	24					Dexamethasone(DB01234)|Tretinoin(DB00755)	GAGGTAGGCGTACTCCTTGGT	0.587000											OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	22					0	0	0.001882	0	0
CASP8	841	broad.mit.edu	37	2	202137359	202137359	+	Splice_Site	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:202137359A>G	ENST00000358485.4	+	4	784		c.e4-1		CASP8_ENST00000264275.5_Splice_Site|CASP8_ENST00000323492.7_Splice_Site|CASP8_ENST00000392266.3_Splice_Site|CASP8_ENST00000432109.2_Splice_Site|CASP8_ENST00000392259.2_Splice_Site|CASP8_ENST00000264274.9_Splice_Site|CASP8_ENST00000392258.3_Splice_Site	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase						activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						TCCTCCTCTTAGAACCTGCTG	0.408000										HNSCC(4;0.00038)			27	52					0	0	0.005443	0	0
TLR7	51284	broad.mit.edu	37	X	12906382	12906382	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:12906382C>G	ENST00000380659.3	+	3	2894	c.2755C>G	c.(2755-2757)Cca>Gca	p.P919A		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	919	TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	ACTGGAAGACCCAAGAGAGAA	0.458000													56	47					0	0	0.003610	0	0
UGT3A1	133688	broad.mit.edu	37	5	35991303	35991303	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:35991303G>T	ENST00000274278.3	-	1	397	c.40C>A	c.(40-42)Ctt>Att	p.L14I	UGT3A1_ENST00000503189.1_Missense_Mutation_p.L14I|UGT3A1_ENST00000333811.4_Intron|UGT3A1_ENST00000507113.1_Missense_Mutation_p.L14I|UGT3A1_ENST00000513233.1_5'UTR	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	14						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACCCCAGAAAGAAGGAAGGCC	0.612000													33	79					6.00712e-18	1.36848e-17	0.002445	1	0
CSMD3	114788	broad.mit.edu	37	8	113418923	113418923	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:113418923G>A	ENST00000297405.5	-	35	5883	c.5639C>T	c.(5638-5640)tCt>tTt	p.S1880F	CSMD3_ENST00000455883.2_Missense_Mutation_p.S1776F|CSMD3_ENST00000343508.3_Missense_Mutation_p.S1840F|CSMD3_ENST00000352409.3_Missense_Mutation_p.S1810F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1880	Sushi 10.					integral to membrane|plasma membrane		p.S1880Y(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTCAGGCACAGAACTGCATTG	0.338000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	48					0	0	0.002299	0	0
DUSP27	92235	broad.mit.edu	37	1	167097589	167097589	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:167097589C>T	ENST00000361200.2	+	6	3387	c.3221C>T	c.(3220-3222)tCa>tTa	p.S1074L	DUSP27_ENST00000443333.1_Missense_Mutation_p.S1074L|DUSP27_ENST00000271385.5_Missense_Mutation_p.S1074L|DUSP27_ENST00000485151.1_Intron			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	1074					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						GTGGAAGAGTCATCCAAGTCA	0.522000													10	14					0	0	0.000443	0	0
SLC16A7	9194	broad.mit.edu	37	12	60173400	60173400	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:60173400T>C	ENST00000261187.4	+	5	1541	c.1377T>C	c.(1375-1377)gaT>gaC	p.D459D	SLC16A7_ENST00000543448.1_Silent_p.D360D|SLC16A7_ENST00000552432.1_Silent_p.D459D|SLC16A7_ENST00000552024.1_Silent_p.D459D|SLC16A7_ENST00000547379.1_Silent_p.D459D	NM_001270622.1|NM_001270623.1|NM_004731.3	NP_001257551.1|NP_001257552.1|NP_004722.2	O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7	459						integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	ATTCGGAAGATGTTAACGTCA	0.368000													7	19					0	0	0.001984	0	0
ZCCHC4	29063	broad.mit.edu	37	4	25314461	25314461	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:25314461C>A	ENST00000302874.4	+	1	54	c.30C>A	c.(28-30)gcC>gcA	p.A10A	ZCCHC4_ENST00000505451.1_3'UTR	NM_024936.2	NP_079212.2	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	10							methyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)	9		Breast(46;0.0503)				GGTTTGAAGCCGTGGAGGCAG	0.652000											OREG0016141	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	47	108					6.7651e-33	1.71002e-32	0.003610	1	0
MTDH	92140	broad.mit.edu	37	8	98731417	98731417	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:98731417G>T	ENST00000336273.3	+	10	1849	c.1521_splice	c.e10+1	p.Q507_splice	MTDH_ENST00000519934.1_Splice_Site_p.Q451_splice	NM_178812.3	NP_848927.2	Q86UE4	LYRIC_HUMAN	metadherin	507					lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			AAAATAGCCAGGTAATTTTTA	0.458000													24	54					1.5548e-18	3.57444e-18	0.005443	1	0
ARL4A	10124	broad.mit.edu	37	7	12728069	12728069	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:12728069G>C	ENST00000396663.1	+	2	672	c.190G>C	c.(190-192)Gga>Cga	p.G64R	ARL4A_ENST00000396662.1_Missense_Mutation_p.G64R|ARL4A_ENST00000356797.3_Missense_Mutation_p.G64R|ARL4A_ENST00000396664.2_Missense_Mutation_p.G64R|ARL4A_ENST00000404894.1_Missense_Mutation_p.G64R	NM_001037164.2|NM_001195396.1|NM_005738.4|NM_212460.3	NP_001032241.1|NP_001182325.1|NP_005729.1|NP_997625.1	P40617	ARL4A_HUMAN	ADP-ribosylation factor-like 4A	64					small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|protein binding			NS(2)|lung(3)|ovary(1)	6				UCEC - Uterine corpus endometrioid carcinoma (126;0.176)		GGTAACCTTGGGAAATTCTAA	0.398000													12	48					0	0	0.003163	0	0
TNIK	23043	broad.mit.edu	37	3	170805171	170805171	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:170805171C>T	ENST00000436636.2	-	24	3190	c.2846G>A	c.(2845-2847)cGc>cAc	p.R949H	TNIK_ENST00000357327.5_Missense_Mutation_p.R920H|TNIK_ENST00000341852.6_Missense_Mutation_p.R865H|TNIK_ENST00000284483.8_Missense_Mutation_p.R941H|TNIK_ENST00000538048.1_Missense_Mutation_p.R901H|TNIK_ENST00000369326.5_Missense_Mutation_p.R927H|TNIK_ENST00000460047.1_Missense_Mutation_p.R886H|TNIK_ENST00000488470.1_Missense_Mutation_p.R894H|TNIK_ENST00000470834.1_Missense_Mutation_p.R912H|TNIK_ENST00000475336.1_Missense_Mutation_p.R857H	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	949	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GGTTGAGACGCGCCCCAGTCC	0.582000													26	146					0	0	0.005443	0	0
NOP14	8602	broad.mit.edu	37	4	2958516	2958516	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:2958516A>G	ENST00000416614.2	-	3	418	c.353T>C	c.(352-354)aTc>aCc	p.I118T	NOP14_ENST00000398071.4_Missense_Mutation_p.I118T|NOP14_ENST00000314262.6_Missense_Mutation_p.I118T|NOP14-AS1_ENST00000503709.1_RNA|NOP14_ENST00000502735.1_Missense_Mutation_p.I118T			P78316	NOP14_HUMAN	NOP14 nucleolar protein	118					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	30						TAGATTGTAGATGCTTTTTTT	0.358000													7	40					0	0	0.001984	0	0
MCTP1	79772	broad.mit.edu	37	5	94353071	94353071	+	Splice_Site	SNP	C	C	A	rs111625916		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:94353071C>A	ENST00000515393.1	-	2	837	c.838_splice	c.e2+1	p.G280_splice	MCTP1_ENST00000429576.2_Splice_Site_p.G59_splice|MCTP1_ENST00000312216.8_Splice_Site_p.G59_splice|MCTP1_ENST00000505208.1_Splice_Site_p.G59_splice	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	280	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding	p.G280R(1)		breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		ATGCTCTTACCTCCTCGATCT	0.403000													28	71					1.13719e-10	2.23759e-10	0.001512	1	0
ACSS3	79611	broad.mit.edu	37	12	81627154	81627154	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:81627154T>C	ENST00000548058.1	+	13	2533	c.1623T>C	c.(1621-1623)ggT>ggC	p.G541G	ACSS3_ENST00000548324.1_Silent_p.G223G|ACSS3_ENST00000261206.3_Silent_p.G540G			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	541						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						TGGATGCTGGTTACATGGATG	0.343000													31	99					0	0	0.001786	0	0
NOL11	25926	broad.mit.edu	37	17	65717512	65717512	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:65717512A>G	ENST00000253247.4	+	4	446	c.331A>G	c.(331-333)Agg>Ggg	p.R111G	NOL11_ENST00000581966.1_3'UTR|NOL11_ENST00000535137.1_5'UTR	NM_015462.3	NP_056277.2	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	111						nucleolus				haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	11	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			AGAAGTATATAGGATACTTTC	0.368000													16	61					0	0	0.004990	0	0
CR1	1378	broad.mit.edu	37	1	207790123	207790123	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:207790123C>G	ENST00000367049.4	+	41	6865	c.6865C>G	c.(6865-6867)Cgc>Ggc	p.R2289G	CR1_ENST00000367053.1_Missense_Mutation_p.R1839G|CR1_ENST00000400960.2_Missense_Mutation_p.R1839G|CR1_ENST00000367051.1_Missense_Mutation_p.R1839G|CR1_ENST00000367052.1_Missense_Mutation_p.R1839G	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1839					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CCCTGCCCCTCGCTGTGAACT	0.507000													37	114					0	0	0.004878	0	0
TNC	3371	broad.mit.edu	37	9	117849088	117849088	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:117849088C>A	ENST00000350763.4	-	3	1333	c.922G>T	c.(922-924)Gaa>Taa	p.E308*	TNC_ENST00000542877.1_Nonsense_Mutation_p.E308*|TNC_ENST00000341037.4_Nonsense_Mutation_p.E308*|TNC_ENST00000535648.1_Nonsense_Mutation_p.E308*|TNC_ENST00000346706.3_Nonsense_Mutation_p.E308*|TNC_ENST00000537320.1_Nonsense_Mutation_p.E308*|TNC_ENST00000340094.3_Nonsense_Mutation_p.E308*|TNC_ENST00000345230.3_Nonsense_Mutation_p.E308*|TNC_ENST00000423613.2_Nonsense_Mutation_p.E308*	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	308	EGF-like 5.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						CTGCAGTCTTCGCCCGTGAAA	0.557000													53	79					2.12129e-23	5.19832e-23	0.003610	1	0
ENPEP	2028	broad.mit.edu	37	4	111470910	111470910	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:111470910G>T	ENST00000265162.5	+	17	2711	c.2369G>T	c.(2368-2370)gGg>gTg	p.G790V		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	790					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TATCGGTATGGGATGCAGAAC	0.388000													16	62					1.99824e-07	3.62609e-07	0.004990	1	0
KIRREL2	84063	broad.mit.edu	37	19	36357124	36357124	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:36357124T>C	ENST00000360202.5	+	15	2055	c.1857T>C	c.(1855-1857)ccT>ccC	p.P619P	KIRREL2_ENST00000586102.2_Silent_p.P599P|NPHS1_ENST00000591817.1_Intron|KIRREL2_ENST00000347900.6_Intron|KIRREL2_ENST00000262625.7_Intron|KIRREL2_ENST00000592409.1_Silent_p.P584P	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	619					cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCGAAGCCCCTGGAGGAGGTC	0.607000													20	88					0	0	0.001216	0	0
OR5D16	390144	broad.mit.edu	37	11	55607036	55607036	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55607036G>T	ENST00000378396.1	+	1	809	c.809G>T	c.(808-810)aGg>aTg	p.R270M		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				AAAAACTCCAGGCACACAGTC	0.493000													21	67					3.62473e-10	7.0561e-10	0.001882	1	0
PPP4R4	57718	broad.mit.edu	37	14	94711942	94711942	+	Missense_Mutation	SNP	G	G	T	rs143566515		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:94711942G>T	ENST00000304338.3	+	13	1517	c.1363G>T	c.(1363-1365)Gat>Tat	p.D455Y		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	455						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TGCTCTTATAGATCATCTTCC	0.313000													24	66					3.5997e-14	7.62893e-14	0.002299	1	0
CCDC27	148870	broad.mit.edu	37	1	3679735	3679735	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:3679735G>T	ENST00000294600.2	+	7	1102	c.1018G>T	c.(1018-1020)Gac>Tac	p.D340Y		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	340	Glu-rich.									breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		TGGCGAGGAGGACGAGGGCCT	0.682000													3	0					0.004672	0.00755576	0.004672	1	0
OR5M3	219482	broad.mit.edu	37	11	56237807	56237807	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56237807G>T	ENST00000312240.2	-	1	207	c.167C>A	c.(166-168)cCc>cAc	p.P56H		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	56					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					AAAGTACATGGGGTTGTTAAG	0.398000													17	46					6.94344e-10	1.34642e-09	0.006122	1	0
PDHA2	5161	broad.mit.edu	37	4	96761796	96761796	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:96761796C>A	ENST00000295266.4	+	1	558	c.495C>A	c.(493-495)gtC>gtA	p.V165V		NM_005390.4	NP_005381.1	P29803	ODPAT_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 2	165					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	ATGGCATCGTCGGTGCACAGG	0.507000													26	69					3.28513e-13	6.76925e-13	0.003954	1	0
TBC1D1	23216	broad.mit.edu	37	4	37903767	37903767	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:37903767C>A	ENST00000261439.4	+	2	406	c.51C>A	c.(49-51)gtC>gtA	p.V17V	TBC1D1_ENST00000402522.1_Silent_p.V17V|TBC1D1_ENST00000508802.1_Silent_p.V17V	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	17						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						CTAACGAGGTCTCGGTGGATT	0.522000													31	73					3.99451e-17	8.97758e-17	0.001786	1	0
FCAMR	83953	broad.mit.edu	37	1	207131928	207131928	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:207131928A>T	ENST00000324852.4	-	8	2141	c.1667T>A	c.(1666-1668)aTg>aAg	p.M556K	FCAMR_ENST00000450945.2_3'UTR|FCAMR_ENST00000486178.1_5'UTR|FCAMR_ENST00000400962.3_3'UTR	NM_001170631.1	NP_001164102.1	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity	511						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(1)	11						ATCCTGGAGCATCTTTCTTTC	0.537000													28	62					0	0	0.002445	0	0
REG1P	5969	broad.mit.edu	37	2	79364439	79364439	+	RNA	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:79364439C>A	ENST00000444841.1	-	0	195																											CTGATCTGGGCCTTGGGCAAC	0.507000													13	10					2.27111e-07	4.10641e-07	0.001368	1	0
SLC6A10P	386757	broad.mit.edu	37	16	32891911	32891911	+	RNA	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:32891911G>T	ENST00000330048.5	-	0	2812					NR_003083.2																						TGACAGCCAGGATGATGGCGT	0.632000													16	61					1.01871e-10	2.00643e-10	0.001216	1	0
ZNF248	57209	broad.mit.edu	37	10	38121829	38121829	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:38121829C>A	ENST00000395867.3	-	6	1004	c.454G>T	c.(454-456)Ggc>Tgc	p.G152C	ZNF248_ENST00000374648.3_Intron|ZNF248_ENST00000357328.4_Missense_Mutation_p.G152C|ZNF248_ENST00000494133.1_Intron	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						ATAATTAAGCCCGAAATATTT	0.323000													21	39					2.4624e-09	4.69775e-09	0.001216	1	0
NEK5	341676	broad.mit.edu	37	13	52676308	52676308	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:52676308G>A	ENST00000355568.4	-	10	869	c.730C>T	c.(730-732)Cct>Tct	p.P244S		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	244	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CGGTCTCGAGGAGATACTTGA	0.423000													5	149					0	0	0.000602	0	0
ZNF629	23361	broad.mit.edu	37	16	30794552	30794552	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:30794552C>A	ENST00000262525.4	-	3	1304	c.1097G>T	c.(1096-1098)cGg>cTg	p.R366L		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			CAGGTGAGTCCGCTGGTGCTT	0.662000													19	25					2.5808e-16	5.75518e-16	0.006122	1	0
PDE1C	5137	broad.mit.edu	37	7	31890356	31890356	+	Splice_Site	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:31890356C>G	ENST00000396184.3	-	9	955		c.e9-1		PDE1C_ENST00000396182.2_Splice_Site|PDE1C_ENST00000396193.1_Splice_Site|PDE1C_ENST00000396191.1_Splice_Site|PDE1C_ENST00000321453.7_Splice_Site	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa						activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			TCAGCCAGTTCTGAAAGGAGA	0.468000													17	44					0	0	0.004990	0	0
OR4C6	219432	broad.mit.edu	37	11	55433323	55433323	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55433323C>A	ENST00000314259.3	+	1	710	c.681C>A	c.(679-681)agC>agA	p.S227R		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						AGTCTTACAGCTCTAAAGGGC	0.498000													37	99					4.11147e-13	8.45464e-13	0.003755	1	0
KIAA1244	57221	broad.mit.edu	37	6	138576847	138576847	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:138576847C>A	ENST00000251691.4	+	10	1211	c.1045C>A	c.(1045-1047)Cga>Aga	p.R349R		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	349					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CCTCTACCACCGAGTGCTGCT	0.602000													6	14					0.00116845	0.00191591	0.001168	1	0
SPDYE4	388333	broad.mit.edu	37	17	8656718	8656718	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:8656718G>A	ENST00000328794.6	-	5	751	c.575C>T	c.(574-576)cCc>cTc	p.P192L		NM_001128076.1	NP_001121548.1	A6NLX3	SPDE4_HUMAN	speedy/RINGO cell cycle regulator family member E4	192										breast(1)|endometrium(2)|kidney(1)	4						ATGGAACAAGGGTCGCTGGGA	0.567000													5	14					0	0	0.000602	0	0
MYLK	4638	broad.mit.edu	37	3	123427705	123427705	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:123427705C>A	ENST00000360772.3	-	16	2358	c.1980G>T	c.(1978-1980)ggG>ggT	p.G660G	MYLK_ENST00000346322.5_Silent_p.G591G|MYLK_ENST00000359169.1_Silent_p.G660G|MYLK_ENST00000360304.3_Silent_p.G660G|MYLK_ENST00000475616.1_Silent_p.G660G			Q15746	MYLK_HUMAN	myosin light chain kinase	660	Ig-like C2-type 5.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GGATCTCATTCCCATTGTGCA	0.562000													22	127					9.95505e-16	2.18597e-15	0.002299	1	0
DCAF8L2	347442	broad.mit.edu	37	X	27766738	27766738	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:27766738G>T	ENST00000451261.2	+	5	2125	c.1726G>T	c.(1726-1728)Gac>Tac	p.D576Y		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						CAGCCTGTTTGACCAGTACAT	0.498000													11	9					1.58986e-06	2.799e-06	0.000673	1	0
ANK3	288	broad.mit.edu	37	10	62039399	62039399	+	Splice_Site	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:62039399T>G	ENST00000280772.1	-	2	306		c.e2-2		ANK3_ENST00000503366.1_Splice_Site|ANK3_ENST00000373827.2_Splice_Site	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGCATCAGACTAAAATAAAAA	0.333000													25	64					0	0	0.004656	0	0
PTGER2	5732	broad.mit.edu	37	14	52781592	52781592	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:52781592G>C	ENST00000245457.5	+	1	480	c.326G>C	c.(325-327)tGc>tCc	p.C109S	PTGER2_ENST00000557436.1_Intron	NM_000956.3	NP_000947.2	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	109						integral to plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	AGCCGCGCGTGCACCTACTTC	0.647000													23	67					0	0	0.002299	0	0
KPTN	11133	broad.mit.edu	37	19	47978726	47978726	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:47978726G>T	ENST00000338134.3	-	12	1365	c.1258C>A	c.(1258-1260)Cag>Aag	p.Q420K	KPTN_ENST00000536339.1_Missense_Mutation_p.Q180K	NM_007059.2	NP_008990.2	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	420					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			breast(1)|lung(3)|ovary(2)|pancreas(2)	8		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		TCCAACCCCTGTAGCCGACGT	0.612000													10	20					3.86212e-05	6.52464e-05	0.000673	1	0
SAMD3	154075	broad.mit.edu	37	6	130536394	130536394	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:130536394C>G	ENST00000532763.1	-	2	154	c.25G>C	c.(25-27)Gtc>Ctc	p.V9L	SAMD3_ENST00000324172.6_Missense_Mutation_p.V9L|SAMD3_ENST00000457563.2_Missense_Mutation_p.V33L|SAMD3_ENST00000439090.2_Missense_Mutation_p.V9L|SAMD3_ENST00000437477.2_Missense_Mutation_p.V9L|SAMD3_ENST00000368134.2_Missense_Mutation_p.V9L|SAMD3_ENST00000533296.1_5'UTR			Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	9	SAM.									breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CAACTGCAGACCTGCTCAACT	0.398000													10	41					0	0	0.001368	0	0
NIN	51199	broad.mit.edu	37	14	51288662	51288662	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:51288662T>G	ENST00000245441.5	-	3	303	c.113A>C	c.(112-114)cAc>cCc	p.H38P	NIN_ENST00000382041.3_Missense_Mutation_p.H38P|NIN_ENST00000382043.4_Missense_Mutation_p.H38P|NIN_ENST00000389868.3_Missense_Mutation_p.H38P|NIN_ENST00000530997.2_Missense_Mutation_p.H38P|NIN_ENST00000324330.9_Missense_Mutation_p.H38P|RP11-286O18.1_ENST00000555966.1_RNA|NIN_ENST00000453196.1_Missense_Mutation_p.H38P	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	38	EF-hand 1.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					GCTCAACATGTGGCAAAGGTC	0.587000			T	PDGFRB	MPD								67	244					0	0	0.003610	0	0
FAT3	120114	broad.mit.edu	37	11	92531613	92531613	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:92531613G>C	ENST00000298047.6	+	9	5451	c.5434G>C	c.(5434-5436)Gtg>Ctg	p.V1812L	FAT3_ENST00000525166.1_Missense_Mutation_p.V1662L|FAT3_ENST00000409404.2_Missense_Mutation_p.V1812L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1812	Cadherin 16.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGCTCTGCTTGTGTATCAGAT	0.478000										TCGA Ovarian(4;0.039)			10	23					0	0	0.000443	0	0
OR4F6	390648	broad.mit.edu	37	15	102346444	102346444	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:102346444A>T	ENST00000328882.4	+	1	543	c.522A>T	c.(520-522)ttA>ttT	p.L174F		NM_001005326.1	NP_001005326.1	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F, member 6	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D175fs*15(1)		breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			CTAATGAATTAGATAGTTTCT	0.373000													48	80					0	0	0.003610	0	0
RP1	6101	broad.mit.edu	37	8	55537480	55537480	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:55537480C>T	ENST00000220676.1	+	4	1186	c.1038C>T	c.(1036-1038)acC>acT	p.T346T		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	346					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AGGAAGAAACCATAAAATGGA	0.343000													9	20					0	0	0.004482	0	0
CSMD3	114788	broad.mit.edu	37	8	113246700	113246700	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:113246700T>C	ENST00000297405.5	-	68	10878	c.10634A>G	c.(10633-10635)tAt>tGt	p.Y3545C	CSMD3_ENST00000455883.2_Missense_Mutation_p.Y3376C|CSMD3_ENST00000343508.3_Missense_Mutation_p.Y3505C|CSMD3_ENST00000352409.3_Missense_Mutation_p.Y3475C	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3545						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CTGGCTTTTATATACCCCTGT	0.313000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			36	82					0	0	0.003271	0	0
T	6862	broad.mit.edu	37	6	166571922	166571922	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:166571922C>A	ENST00000296946.2	-	9	1657	c.1189G>T	c.(1189-1191)Gga>Tga	p.G397*	T_ENST00000366871.3_Nonsense_Mutation_p.G339*	NM_003181.3	NP_003172.1	O15178	BRAC_HUMAN	T, brachyury homolog (mouse)	397					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		AGTGGGGATCCCGAGGAAGAG	0.692000									Chordoma, Familial Clustering of				21	69					9.95505e-16	2.18597e-15	0.002299	1	0
OR4Q3	441669	broad.mit.edu	37	14	20216334	20216334	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20216334C>A	ENST00000331723.1	+	1	748	c.748C>A	c.(748-750)Ctg>Atg	p.L250M		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGTGGTCAGCCTGATCTTCGT	0.453000													35	226					1.96642e-18	4.5104e-18	0.001485	1	0
IZUMO2	126123	broad.mit.edu	37	19	50657863	50657863	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:50657863A>G	ENST00000293405.3	-	6	617	c.617T>C	c.(616-618)gTg>gCg	p.V206A		NM_152358.2	NP_689571.2	Q6UXV1	IZUM2_HUMAN	IZUMO family member 2	206						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						TCACGAGACCACGATGACCAC	0.577000													20	36					0	0	0.001216	0	0
CCDC73	493860	broad.mit.edu	37	11	32705039	32705039	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:32705039T>A	ENST00000531481.1	-	7	748	c.472A>T	c.(472-474)Act>Tct	p.T158S	CCDC73_ENST00000534415.1_Intron|CCDC73_ENST00000335185.5_Intron			Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	0										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					TCCCCCTAAGTACTAATCCAG	0.323000													10	26					0	0	0.000443	0	0
OR5M1	390168	broad.mit.edu	37	11	56380486	56380486	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56380486G>C	ENST00000526538.1	-	1	492	c.493C>G	c.(493-495)Cac>Gac	p.H165D		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						AAGGATAAGTGAAAGGTTAGC	0.463000													20	39					0	0	0.000958	0	0
LINC00842	643650	broad.mit.edu	37	10	47133366	47133366	+	RNA	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:47133366T>A	ENST00000422732.2	-	0	435					NR_033957.1																						CTACTGCTGCTGCTGGAACCG	0.488000													20	184					0	0	0.001216	0	0
NRXN2	9379	broad.mit.edu	37	11	64390225	64390225	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:64390225C>A	ENST00000265459.6	-	21	4634	c.4173_splice	c.e21+1	p.Q1391_splice	NRXN2_ENST00000409571.1_Splice_Site_p.Q1384_splice|NRXN2_ENST00000301894.2_Splice_Site_p.Q345_splice|NRXN2_ENST00000377551.1_Splice_Site_p.Q1391_splice|NRXN2_ENST00000377559.3_Splice_Site_p.Q1321_splice	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1391					cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						GGGGCCTCACCTGGGTGGTGC	0.622000													13	62					0.00185496	0.00303415	0.001855	1	0
TG	7038	broad.mit.edu	37	8	133899673	133899673	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:133899673G>T	ENST00000220616.4	+	9	2096	c.2056G>T	c.(2056-2058)Gct>Tct	p.A686S	TG_ENST00000377869.1_Missense_Mutation_p.A686S	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	686	Thyroglobulin type-1 6.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTTTGTCCCTGCTTGTACTAG	0.557000													21	46					1.01871e-10	2.00643e-10	0.001216	1	0
OR6X1	390260	broad.mit.edu	37	11	123624645	123624645	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:123624645T>A	ENST00000327930.2	-	1	608	c.582A>T	c.(580-582)gaA>gaT	p.E194D		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CGCCCAGGAGTTCCAAAATGC	0.438000													28	70					0	0	0.001271	0	0
EFTUD2	9343	broad.mit.edu	37	17	42931931	42931931	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:42931931G>A	ENST00000426333.2	-	22	2549	c.2252C>T	c.(2251-2253)cCc>cTc	p.P751L	EFTUD2_ENST00000592576.1_Missense_Mutation_p.P741L|EFTUD2_ENST00000591382.1_Missense_Mutation_p.P751L|EFTUD2_ENST00000402521.3_Missense_Mutation_p.P716L	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	751						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				TACCTCAGAGGGCAGAGTATC	0.517000													26	98					0	0	0.001061	0	0
GABBR2	9568	broad.mit.edu	37	9	101216274	101216274	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:101216274A>G	ENST00000259455.2	-	7	1684	c.1225T>C	c.(1225-1227)Ttc>Ctc	p.F409L		NM_005458.7	NP_005449.5	O75899	GABR2_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 2	409					negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity		NOTCH1_ENST00000277541/GABBR2(2)	breast(4)|endometrium(4)|large_intestine(12)|lung(21)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	49		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	GTGACCCCGAAGAAGTTGGTC	0.532000													73	70					0	0	0.003610	0	0
CADM1	23705	broad.mit.edu	37	11	115080341	115080341	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:115080341G>T	ENST00000537058.1	-	8	1051	c.1031C>A	c.(1030-1032)aCc>aAc	p.T344N	CADM1_ENST00000542447.2_Intron|CADM1_ENST00000452722.2_Missense_Mutation_p.T344N|CADM1_ENST00000537140.1_Intron|CADM1_ENST00000331581.6_Missense_Mutation_p.T344N|CADM1_ENST00000536727.1_Intron			Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	344				PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		ggtggtggtggtggttgttgt	0.438000													14	38					4.3838e-07	7.88377e-07	0.001855	1	0
PIEZO2	63895	broad.mit.edu	37	18	10672752	10672752	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:10672752G>C	ENST00000302079.6	-	50	7751	c.7752C>G	c.(7750-7752)gcC>gcG	p.A2584A	PIEZO2_ENST00000580640.1_Silent_p.A2672A|PIEZO2_ENST00000538948.1_Silent_p.A604A|PIEZO2_ENST00000503781.3_Silent_p.A2647A|PIEZO2_ENST00000581680.1_5'UTR|PIEZO2_ENST00000285141.4_Silent_p.A439A			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2647						integral to membrane	ion channel activity										CCAGTTCCAGGGCCTGAGAGT	0.448000													34	288					0	0	0.004289	0	0
SSTR3	6753	broad.mit.edu	37	22	37603377	37603377	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:37603377T>A	ENST00000328544.3	-	2	999	c.466A>T	c.(466-468)Aca>Tca	p.T156S	SSTR3_ENST00000402501.1_Missense_Mutation_p.T156S	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	156					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						ACCGGAGCTGTGCGCCAGCGG	0.677000													30	53					0	0	0.001512	0	0
TMEM200C	645369	broad.mit.edu	37	18	5891787	5891787	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:5891787C>T	ENST00000581347.1	-	3	921	c.276G>A	c.(274-276)gcG>gcA	p.A92A	TMEM200C_ENST00000383490.2_Silent_p.A92A|RP11-945C19.4_ENST00000577694.1_RNA			A6NKL6	T200C_HUMAN	transmembrane protein 200C	92						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						GGCTGCTGCCCGCAGGCGGCA	0.672000													12	131					0	0	0.001855	0	0
ELAVL4	1996	broad.mit.edu	37	1	50661318	50661319	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:50661318_50661319insA	ENST00000371824.1	+	5	851_852	c.594_595insA	c.(592-597)ccgcggfs	p.R199fs	ELAVL4_ENST00000371821.1_Frame_Shift_Ins_p.R204fs|ELAVL4_ENST00000371827.1_Frame_Shift_Ins_p.R199fs|ELAVL4_ENST00000357083.4_Frame_Shift_Ins_p.R216fs|ELAVL4_ENST00000371819.1_Frame_Shift_Ins_p.R204fs|ELAVL4_ENST00000448907.2_Frame_Shift_Ins_p.R202fs|ELAVL4_ENST00000371823.4_Frame_Shift_Ins_p.R199fs			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	199	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						GCCAGAAGCCCAGCGGTGCTAC	0.569													85	63	---	---	---	---					
TXNIP	10628	broad.mit.edu	37	1	145439871	145439874	+	Frame_Shift_Del	DEL	AAAG	AAAG	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:145439871_145439874delAAAG	ENST00000369317.4	+	3	751_754	c.417_420delAAAG	c.(415-420)acfs	p.TK139fs	TXNIP_ENST00000475171.1_Intron	NM_006472.3	NP_006463.3	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	139					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(1)|lung(5)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	21	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTCAAGAGACAAAGAAAAACTTTG	0.441													33	78	---	---	---	---					
NID1	4811	broad.mit.edu	37	1	236208939	236208939	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:236208939delG	ENST00000264187.6	-	3	652	c.570delC	c.(568-570)tcfs	p.S190fs	NID1_ENST00000366595.3_Frame_Shift_Del_p.S190fs	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	190	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	AAATGGCATAGGAGCTGGAAT	0.413													15	35	---	---	---	---					
PLD5	200150	broad.mit.edu	37	1	242253370	242253370	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:242253370delC	ENST00000442594.2	-	11	1630	c.1121delG	c.(1120-1122)gcfs	p.G374fs	PLD5_ENST00000427495.1_Frame_Shift_Del_p.G404fs|PLD5_ENST00000536534.1_Frame_Shift_Del_p.G466fs	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	466						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			AAGGCCCGTGCCAGCATTCTG	0.423													65	85	---	---	---	---					
OTX1	5013	broad.mit.edu	37	2	63283445	63283446	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:63283445_63283446insT	ENST00000282549.2	+	5	1335_1336	c.1059_1060insT	c.(1057-1062)gttgtgfs	p.V354fs	OTX1_ENST00000366671.3_Frame_Shift_Ins_p.V354fs	NM_014562.3	NP_055377.1	P32242	OTX1_HUMAN	orthodenticle homeobox 1	354						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Lung NSC(7;0.121)|all_lung(7;0.211)					GGTTCCAGGTCTTGTGAGCCCA	0.604													15	42	---	---	---	---					
ANXA4	307	broad.mit.edu	37	2	70015233	70015233	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:70015233delG	ENST00000394295.4	+	3	305	c.57delG	c.(55-57)atfs	p.M19fs	ANXA4_ENST00000536030.1_Intron|ANXA4_ENST00000409920.1_Frame_Shift_Del_p.M19fs	NM_001153.3	NP_001144.1	P09525	ANXA4_HUMAN	annexin A4	17					anti-apoptosis|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	11						TCAATGCCATGGAAGATGCCC	0.532													33	90	---	---	---	---					
ERBB4	2066	broad.mit.edu	37	2	212812196	212812196	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:212812196delC	ENST00000342788.4	-	3	690	c.380delG	c.(379-381)gafs	p.G127fs	ERBB4_ENST00000484474.1_5'UTR|ERBB4_ENST00000402597.1_Frame_Shift_Del_p.G127fs|ERBB4_ENST00000436443.1_Frame_Shift_Del_p.G127fs	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	127					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TCCAAAGTTTCCATCTTTTCT	0.338										TSP Lung(8;0.080)			15	29	---	---	---	---					
ZXDC	79364	broad.mit.edu	37	3	126178522	126178522	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:126178522delT	ENST00000389709.3	-	7	2239	c.2186delA	c.(2185-2187)agfs	p.K729fs		NM_025112.4	NP_079388.3	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C	729					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(1)	17				GBM - Glioblastoma multiforme(114;0.155)		TCCTCTCTGCTTTTTTTCCTT	0.522													8	876	---	---	---	---					
PLCH1	23007	broad.mit.edu	37	3	155303945	155303945	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:155303945delC	ENST00000460012.1	-	5	776	c.419delG	c.(418-420)gtfs	p.G140fs	PLCH1_ENST00000447496.2_Frame_Shift_Del_p.G158fs|PLCH1_ENST00000414191.1_Frame_Shift_Del_p.G140fs|PLCH1_ENST00000340059.7_Frame_Shift_Del_p.G158fs|PLCH1_ENST00000334686.6_Frame_Shift_Del_p.G140fs|PLCH1_ENST00000494598.1_Frame_Shift_Del_p.G158fs			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	158					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CAAGCCGTCACCATTCTTATC	0.403													24	88	---	---	---	---					
SPATA16	83893	broad.mit.edu	37	3	172607391	172607392	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:172607391_172607392insT	ENST00000351008.3	-	11	1861_1862	c.1678_1679insA	c.(1678-1680)gaafs	p.E560fs		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	560					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			AAGTCGCTTCATTTTTGTTTTT	0.401													7	273	---	---	---	---					
SPATA16	83893	broad.mit.edu	37	3	172607397	172607397	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:172607397delG	ENST00000351008.3	-	11	1856	c.1673delC	c.(1672-1674)aafs	p.T558fs		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	558					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			CTTCATTTTTGTTTTTTGCCT	0.388													7	254	---	---	---	---					
GAK	2580	broad.mit.edu	37	4	860744	860745	+	Splice_Site	INS	-	-	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:860744_860745insA	ENST00000314167.4	-	21	2981_2982	c.2872_splice	c.e21+1	p.*958_splice	GAK_ENST00000509566.1_5'UTR|GAK_ENST00000511163.1_Splice_Site_p.*879_splice	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	958					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		AAACACGTACCAGCGGCAGGGG	0.629													45	106	---	---	---	---					
KIT	3815	broad.mit.edu	37	4	55598063	55598063	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:55598063delC	ENST00000288135.5	+	16	2357	c.2260delC	c.(2260-2262)ccfs	p.P754fs		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	754	Protein kinase.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGATGTGACTCCCGCCATCAT	0.468		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				26	96	---	---	---	---					
LPHN3	23284	broad.mit.edu	37	4	62933931	62933932	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:62933931_62933932insA	ENST00000512091.1	+	25	4405_4406	c.3658_3659insA	c.(3658-3660)aatfs	p.N1220fs	LPHN3_ENST00000507164.1_Frame_Shift_Ins_p.N1322fs|LPHN3_ENST00000506746.1_Intron|LPHN3_ENST00000506700.1_Frame_Shift_Ins_p.N1211fs|LPHN3_ENST00000511324.1_Frame_Shift_Ins_p.N1279fs|LPHN3_ENST00000506720.1_Intron|LPHN3_ENST00000514157.1_Frame_Shift_Ins_p.N1254fs|LPHN3_ENST00000508946.1_Intron|LPHN3_ENST00000509896.1_Frame_Shift_Ins_p.N1288fs|LPHN3_ENST00000545650.1_Intron|LPHN3_ENST00000514996.1_Intron|LPHN3_ENST00000514591.1_Intron|LPHN3_ENST00000507625.1_Intron|LPHN3_ENST00000508693.1_Frame_Shift_Ins_p.N1331fs|LPHN3_ENST00000504896.1_Frame_Shift_Ins_p.N1263fs			Q9HAR2	LPHN3_HUMAN	latrophilin 3	0					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						CATTGCATATCAAATGTAATTT	0.307													12	68	---	---	---	---					
ZNF608	57507	broad.mit.edu	37	5	123983092	123983092	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:123983092delG	ENST00000306315.5	-	4	3420	c.2985delC	c.(2983-2985)ccfs	p.P995fs	ZNF608_ENST00000504926.1_Frame_Shift_Del_p.P568fs	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	995	Ser-rich.					intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TGTGGTAATAGGGAGAATGGG	0.463													43	107	---	---	---	---					
NSD1	64324	broad.mit.edu	37	5	176675254	176675254	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:176675254delG	ENST00000439151.2	+	11	4615	c.4570delG	c.(4570-4572)ggfs	p.G1524fs	NSD1_ENST00000347982.4_Frame_Shift_Del_p.G1255fs|NSD1_ENST00000354179.4_Frame_Shift_Del_p.G1255fs|NSD1_ENST00000361032.4_Frame_Shift_Del_p.G1421fs	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1524					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ACACGATCCCGGGATGCCTGC	0.493			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			10	21	---	---	---	---					
ESCO2	157570	broad.mit.edu	37	8	27641568	27641569	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:27641568_27641569insA	ENST00000305188.8	+	5	1245_1246	c.1007_1008insA	c.(1006-1008)taafs	p.*336fs	ESCO2_ENST00000397418.2_Intron	NM_001017420.2	NP_001017420.1	Q56NI9	ESCO2_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 2	336					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		TCAGTCAATTCAAAAAGGTGAG	0.351									SC Phocomelia syndrome				12	49	---	---	---	---					
C9orf131	138724	broad.mit.edu	37	9	35044685	35044686	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35044685_35044686insC	ENST00000312292.5	+	2	2106_2107	c.2059_2060insC	c.(2059-2061)cccfs	p.P687fs	C9orf131_ENST00000421362.2_Frame_Shift_Ins_p.P639fs|C9orf131_ENST00000354479.5_Frame_Shift_Ins_p.P614fs	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	687										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			TGAGCTCCCAGCCCCCAGCTCA	0.540													17	55	---	---	---	---					
NHLRC2	374354	broad.mit.edu	37	10	115636695	115636695	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:115636695delG	ENST00000369301.3	+	3	959	c.747delG	c.(745-747)ttfs	p.L249fs		NM_198514.3	NP_940916.2	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	249					cell redox homeostasis					breast(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	15				Epithelial(162;0.017)|all cancers(201;0.0187)		ATAGAATTTTGGTCGTTTGGA	0.358													11	41	---	---	---	---					
OR8K1	390157	broad.mit.edu	37	11	56114379	56114379	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56114379delC	ENST00000279783.2	+	1	959	c.865delC	c.(865-867)ctfs	p.P289fs		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	289					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					CCTGTTGATTCCTATGCTGAA	0.353										HNSCC(65;0.19)			26	90	---	---	---	---					
OR4D9	390199	broad.mit.edu	37	11	59282896	59282896	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:59282896delC	ENST00000329328.3	+	1	511	c.511delC	c.(511-513)ccfs	p.P171fs		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						TTTCTGTGGACCCAATGTTCT	0.532													37	103	---	---	---	---					
IRAK3	11213	broad.mit.edu	37	12	66638281	66638282	+	Frame_Shift_Ins	INS	-	-	GATGA			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:66638281_66638282insGATGA	ENST00000261233.4	+	9	1324_1325	c.903_904insGATGA	c.(901-906)ttatgafs	p.*302fs	IRAK3_ENST00000457197.2_Frame_Shift_Ins_p.*241fs	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	302	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		ACATCCTTTTGGATGATCAGTT	0.396													10	47	---	---	---	---					
TPH2	121278	broad.mit.edu	37	12	72335486	72335487	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:72335486_72335487insT	ENST00000333850.3	+	2	369_370	c.228_229insT	c.(226-231)ggtggtfs	p.G77fs	TPH2_ENST00000546576.1_3'UTR	NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	77	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	AAGTTGGTGGATTGGTAAAAGC	0.416													34	65	---	---	---	---					
CMKLR1	1240	broad.mit.edu	37	12	108686440	108686440	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:108686440delG	ENST00000312143.7	-	3	663	c.300delC	c.(298-300)gcfs	p.A100fs	CMKLR1_ENST00000552995.1_Frame_Shift_Del_p.A98fs|CMKLR1_ENST00000412676.1_Frame_Shift_Del_p.A100fs|CMKLR1_ENST00000550402.1_Frame_Shift_Del_p.A100fs|CMKLR1_ENST00000397688.2_Frame_Shift_Del_p.A98fs	NM_001142344.1|NM_004072.2	NP_001135816.1|NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	100					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						GGTAGTCCATGGCGGCATAGG	0.498													18	72	---	---	---	---					
GLT1D1	144423	broad.mit.edu	37	12	129442110	129442110	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:129442110delG	ENST00000442111.2	+	11	889	c.801delG	c.(799-801)ccfs	p.P267fs	GLT1D1_ENST00000281703.6_Frame_Shift_Del_p.P187fs|GLT1D1_ENST00000542193.1_Frame_Shift_Del_p.P184fs|GLT1D1_ENST00000537468.1_Frame_Shift_Del_p.P272fs			Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	267					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		TAGAAGTACCGGTATTGGCCA	0.527													11	21	---	---	---	---					
TPTE2P1	646405	broad.mit.edu	37	13	25527490	25527491	+	RNA	INS	-	-	AAAAAG			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:25527490_25527491insAAAAAG	ENST00000429698.1	-	0	282																											AGGAAGGTTCTAAAAAAAATTT	0.252													3	5	---	---	---	---					
RB1	5925	broad.mit.edu	37	13	48955409	48955409	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:48955409delG	ENST00000267163.4	+	17	1663	c.1525delG	c.(1525-1527)gafs	p.G509fs		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	509	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(8)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTTGATTCTGGAACAGATTT	0.294		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			10	11	---	---	---	---					
GABRB3	2562	broad.mit.edu	37	15	26806276	26806276	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:26806276delC	ENST00000541819.2	-	9	1153	c.1051delG	c.(1051-1053)agfs	p.E351fs	GABRB3_ENST00000299267.4_Frame_Shift_Del_p.E295fs|GABRB3_ENST00000400188.3_Frame_Shift_Del_p.E224fs|GABRB3_ENST00000311550.5_Frame_Shift_Del_p.E295fs|GABRB3_ENST00000545868.1_Frame_Shift_Del_p.E210fs			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	295					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGCAAGGTCTCCCGAAGGTGG	0.473													28	51	---	---	---	---					
STRA6	64220	broad.mit.edu	37	15	74490147	74490147	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:74490147delG	ENST00000323940.5	-	3	371	c.126delC	c.(124-126)tcfs	p.S42fs	STRA6_ENST00000574278.1_Frame_Shift_Del_p.S57fs|STRA6_ENST00000535552.1_Frame_Shift_Del_p.S79fs|STRA6_ENST00000449139.2_Frame_Shift_Del_p.S42fs|STRA6_ENST00000574439.1_5'UTR|STRA6_ENST00000423167.2_Frame_Shift_Del_p.S42fs|STRA6_ENST00000563965.1_Frame_Shift_Del_p.S81fs|STRA6_ENST00000395105.4_Frame_Shift_Del_p.S42fs|STRA6_ENST00000416286.3_Frame_Shift_Del_p.S42fs|STRA6_ENST00000432245.2_Frame_Shift_Del_p.S42fs	NM_001142617.1|NM_001142618.1|NM_001142619.1	NP_001136089.1|NP_001136090.1|NP_001136091.1	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid 6	42					adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|stomach(2)	26						TGGTGTGGCAGGAGGGCACTT	0.622													15	25	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102312420	102312421	+	RNA	INS	-	-	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:102312420_102312421insT	ENST00000561463.1	+	0	13788_13789																											CTTCCTTGTCCTGGACCAGCCT	0.584													14	39	---	---	---	---					
APOBR	55911	broad.mit.edu	37	16	28508798	28508798	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:28508798delG	ENST00000564831.1	+	2	2469	c.2436delG	c.(2434-2436)gafs	p.E812fs	APOBR_ENST00000431282.1_Frame_Shift_Del_p.E803fs|APOBR_ENST00000328423.5_Frame_Shift_Del_p.E803fs	NM_018690.3	NP_061160.3	Q0VD83	APOBR_HUMAN	apolipoprotein B receptor	803	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|skin(2)|stomach(1)	29						TTGGTCTGGAGGGCTCAGCAG	0.587													8	49	---	---	---	---					
CYLD	1540	broad.mit.edu	37	16	50811792	50811792	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:50811792delG	ENST00000540145.1	+	8	1493	c.1078delG	c.(1078-1080)ggfs	p.G360fs	CYLD_ENST00000568704.2_Frame_Shift_Del_p.G357fs|CYLD_ENST00000566206.1_Frame_Shift_Del_p.G357fs|CYLD_ENST00000427738.3_Frame_Shift_Del_p.G360fs|CYLD_ENST00000398568.2_Frame_Shift_Del_p.G357fs|CYLD_ENST00000311559.9_Frame_Shift_Del_p.G360fs|CYLD_ENST00000564326.1_Frame_Shift_Del_p.G357fs|CYLD_ENST00000569418.1_Frame_Shift_Del_p.G357fs			Q9NQC7	CYLD_HUMAN	cylindromatosis (turban tumor syndrome)	360	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding	p.G360L(1)		central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(9)|lung(17)|pancreas(1)|skin(22)|upper_aerodigestive_tract(1)	62		all_cancers(37;0.0156)				TACCTTAAATGGGTCTTCTGT	0.299			"""Mis, N, F, S"""		cylindroma	cylindroma			Multiple Trichoepithelioma, Familial;Familial Cylindromatosis				41	47	---	---	---	---					
RTN4RL1	146760	broad.mit.edu	37	17	1841024	1841025	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:1841024_1841025delCA	ENST00000331238.5	-	2	109_110	c.91_92delTG	c.(91-93)cfs	p.C31fs		NM_178568.2	NP_848663.1	Q86UN2	R4RL1_HUMAN	reticulon 4 receptor-like 1	31	LRRNT.				axon regeneration	anchored to plasma membrane	receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|prostate(2)|skin(1)	11						CGCCGGGTAGCACACACAGTCC	0.658													13	36	---	---	---	---					
SLC16A3	9123	broad.mit.edu	37	17	80195732	80195732	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:80195732delG	ENST00000581287.1	+	3	3408	c.1086delG	c.(1084-1086)atfs	p.M362fs	SLC16A3_ENST00000582743.1_Frame_Shift_Del_p.M362fs|SLC16A3_ENST00000392339.1_Frame_Shift_Del_p.M362fs|SLC16A3_ENST00000392341.1_Frame_Shift_Del_p.M362fs	NM_001206951.1|NM_001206952.1	NP_001193880.1|NP_001193881.1	O15427	MOT4_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 3	362					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	TGCTGCTGATGGAGGCGGTGG	0.682													10	30	---	---	---	---					
ANKRD30B	374860	broad.mit.edu	37	18	14752966	14752966	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:14752966delG	ENST00000358984.4	+	3	645	c.465delG	c.(463-465)gtfs	p.V155fs	ANKRD30B_ENST00000579292.1_Intron|ANKRD30B_ENST00000447268.2_Frame_Shift_Del_p.V155fs	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	155										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TGTTAATGGTGGCAACACTGC	0.363													10	31	---	---	---	---					
ASXL3	80816	broad.mit.edu	37	18	31319219	31319219	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:31319219delC	ENST00000269197.5	+	11	1851	c.1851delC	c.(1849-1851)agfs	p.S617fs		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	617	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CTTCTGAGAGCCCAGAGGGAG	0.473													15	13	---	---	---	---					
MAST1	22983	broad.mit.edu	37	19	12951880	12951880	+	Splice_Site	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:12951880delG	ENST00000251472.4	+	3	287	c.248_splice	c.e3+1	p.R83_splice	MAST1_ENST00000591495.1_Splice_Site_p.R79_splice	NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	83					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						TCCTCCCGAAGGTGAGTCCCT	0.637													25	67	---	---	---	---					
CYP4F22	126410	broad.mit.edu	37	19	15651434	15651434	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:15651434delG	ENST00000269703.2	+	8	1044	c.845delG	c.(844-846)cgfs	p.R284fs	CYP4F22_ENST00000601005.2_Frame_Shift_Del_p.R284fs	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	284						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						ATCCAGGAACGGCGGCGGGCA	0.617													33	70	---	---	---	---					
ZNF99	7652	broad.mit.edu	37	19	22941185	22941186	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:22941185_22941186insA	ENST00000397104.3	-	5	1251_1252	c.1252_1253insT	c.(1252-1254)caafs	p.Q418fs	ZNF99_ENST00000596209.1_Frame_Shift_Ins_p.Q509fs					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTCACATTTGCAAGGTTTCTCT	0.351													19	67	---	---	---	---					
TTYH1	57348	broad.mit.edu	37	19	54933436	54933436	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54933436delC	ENST00000301194.4	+	4	612	c.490delC	c.(490-492)cgfs	p.P164fs	TTYH1_ENST00000376530.3_Frame_Shift_Del_p.P164fs|TTYH1_ENST00000391739.3_Frame_Shift_Del_p.P213fs|TTYH1_ENST00000376531.3_Frame_Shift_Del_p.P164fs			Q9H313	TTYH1_HUMAN	tweety family member 1	164					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		GGTGCTCGAGCCGCGCACGGA	0.716													3	6	---	---	---	---					
DMD	1756	broad.mit.edu	37	X	31198490	31198490	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:31198490delA	ENST00000357033.4	-	69	10289	c.10083delT	c.(10081-10083)acfs	p.T3361fs	DMD_ENST00000361471.4_Frame_Shift_Del_p.T293fs|DMD_ENST00000474231.1_Frame_Shift_Del_p.T901fs|DMD_ENST00000359836.1_Frame_Shift_Del_p.T901fs|DMD_ENST00000343523.2_Frame_Shift_Del_p.T901fs|DMD_ENST00000378680.2_Frame_Shift_Del_p.T293fs|DMD_ENST00000541735.1_Frame_Shift_Del_p.T901fs|DMD_ENST00000378702.4_Frame_Shift_Del_p.T293fs|DMD_ENST00000378707.3_Frame_Shift_Del_p.T901fs|DMD_ENST00000378723.3_Frame_Shift_Del_p.T293fs|DMD_ENST00000378677.2_Frame_Shift_Del_p.T3357fs	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	3361	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AACTTACCGGAGTGCAATATT	0.408													9	12	---	---	---	---					
ZMYM3	9203	broad.mit.edu	37	X	70469326	70469327	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:70469326_70469327insT	ENST00000373998.1	-	7	2151_2152	c.1454_1455insA	c.(1453-1455)tggfs	p.W485fs	ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373988.1_Frame_Shift_Ins_p.W487fs|ZMYM3_ENST00000353904.2_Frame_Shift_Ins_p.W485fs|ZMYM3_ENST00000373982.1_Frame_Shift_Ins_p.W487fs|ZMYM3_ENST00000373978.1_3'UTR|ZMYM3_ENST00000373984.3_Frame_Shift_Ins_p.W487fs|ZMYM3_ENST00000373981.1_Frame_Shift_Ins_p.W485fs|ZMYM3_ENST00000314425.5_Frame_Shift_Ins_p.W485fs	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	485					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					TGTACGCCCCCAAGCAGGTTGT	0.564													6	7	---	---	---	---					
L1CAM	3897	broad.mit.edu	37	X	153132315	153132315	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:153132315delC	ENST00000370060.1	-	19	2409	c.2220delG	c.(2218-2220)tgfs	p.W740fs	L1CAM_ENST00000361699.4_Frame_Shift_Del_p.W740fs|L1CAM_ENST00000543994.1_Frame_Shift_Del_p.W742fs|L1CAM_ENST00000538883.1_Frame_Shift_Del_p.W742fs|L1CAM_ENST00000370057.3_Frame_Shift_Del_p.W740fs|L1CAM_ENST00000361981.3_Frame_Shift_Del_p.W735fs|L1CAM_ENST00000370055.1_Frame_Shift_Del_p.W735fs	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	740	Fibronectin type-III 2.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGTCCATCCACCGGAGCG	0.652													25	17	---	---	---	---					
