Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PRKD3	23683	broad.mit.edu	37	2	37505102	37505102	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr2:37505102C>T	ENST00000379066.1	-	9	1965	c.1203G>A	c.(1201-1203)atG>atA	p.M401I	PRKD3_ENST00000234179.2_Missense_Mutation_p.M401I			O94806	KPCD3_HUMAN	protein kinase D3	401					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				GTACAACCCTCATTAGCGGAA	0.363000													15	99					0	0	0.00244969	0	0
ZNF383	163087	broad.mit.edu	37	19	37733547	37733547	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:37733547C>G	ENST00000589413.1	+	8	992	c.409C>G	c.(409-411)Cat>Gat	p.H137D	ZNF383_ENST00000352998.3_Missense_Mutation_p.H137D|ZNF383_ENST00000590503.1_Missense_Mutation_p.H137D			Q8NA42	ZN383_HUMAN	zinc finger protein 383	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)	15			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCCAAATGGGCATTTTAGTCA	0.373000													49	109					0	0	0.000781405	0	0
CASZ1	54897	broad.mit.edu	37	1	10714479	10714479	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr1:10714479C>T	ENST00000377022.3	-	10	2152	c.1835G>A	c.(1834-1836)tGc>tAc	p.C612Y	CASZ1_ENST00000344008.5_Missense_Mutation_p.C612Y	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	612					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CGCTTACCTGCAGTGGAAGTG	0.652000													24	51					0	0	0.00229938	0	0
KRTAP5-AS1	338651	broad.mit.edu	37	11	1619556	1619556	+	RNA	SNP	T	T	C			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr11:1619556T>C	ENST00000424148.1	+	0	1407					NR_021489.1																						TCCCTGAGCCTGGGCTCTTTA	0.522000													4	84					0	0	0.000978159	0	0
SNHG14	104472715	broad.mit.edu	37	15	25417850	25417850	+	RNA	SNP	T	T	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr15:25417850T>A	ENST00000549301.1	+	0	503				SNORD115-2_ENST00000362842.1_RNA|SNHG14_ENST00000553149.1_RNA																							CTCAATAGGATTATGCTGAGG	0.517000													81	154					0	0	0.000781405	0	0
BLNK	29760	broad.mit.edu	37	10	97987176	97987176	+	Silent	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr10:97987176G>A	ENST00000224337.5	-	5	492	c.351C>T	c.(349-351)ggC>ggT	p.G117G	BLNK_ENST00000413476.2_Silent_p.G117G|BLNK_ENST00000371176.2_Silent_p.G117G|BLNK_ENST00000427367.2_Silent_p.G117G	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	117	Pro-rich.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		CTATATACTCGCCTCTGGCGA	0.652000													35	61					0	0	0.00058488	0	0
NWD1	284434	broad.mit.edu	37	19	16902349	16902349	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:16902349C>G	ENST00000524140.2	+	14	3547	c.3129C>G	c.(3127-3129)atC>atG	p.I1043M	NWD1_ENST00000552788.1_Missense_Mutation_p.I1043M|NWD1_ENST00000523826.1_Missense_Mutation_p.I837M|NWD1_ENST00000339803.6_Missense_Mutation_p.I908M|NWD1_ENST00000549814.1_Missense_Mutation_p.I1043M|NWD1_ENST00000379808.3_Missense_Mutation_p.I1043M	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1043							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TGTCCAGCATCAAAGAAGAAA	0.517000													34	69					0	0	0.0024448	0	0
ABO	28	broad.mit.edu	37	9	136132874	136132874	+	RNA	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr9:136132874G>A	ENST00000453660.2	-	0	306							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		GATGTTGAATGTGCCCTCCCA	0.557000													33	38					0	0	0.00209593	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728546	20728546	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:20728546G>C	ENST00000427401.4	-	4	557	c.463C>G	c.(463-465)Cat>Gat	p.H155D		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	155					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						GAAAATTTATGAATGACTTTC	0.308000													17	29					0	0	0.000422831	0	0
PKM	5315	broad.mit.edu	37	15	72501133	72501133	+	Missense_Mutation	SNP	G	G	A	rs143294717		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr15:72501133G>A	ENST00000319622.6	-	6	1121	c.665C>T	c.(664-666)tCg>tTg	p.S222L	PKM_ENST00000389093.3_Missense_Mutation_p.S222L|PKM_ENST00000568883.1_Missense_Mutation_p.S57L|PKM_ENST00000568459.1_Missense_Mutation_p.S222L|PKM_ENST00000565184.1_Missense_Mutation_p.S222L|PKM_ENST00000335181.5_Missense_Mutation_p.S222L|PKM_ENST00000449901.2_Missense_Mutation_p.S207L|PKM_ENST00000565154.1_Missense_Mutation_p.S222L	NM_001206796.1|NM_182470.2|NM_182471.2	NP_001193725.1|NP_872270.1|NP_872271.1			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						GTCCTTCTCCGACACAGCAGG	0.547000													36	78					0	0	0.000814825	0	0
PLEKHO1	51177	broad.mit.edu	37	1	150129105	150129105	+	Splice_Site	SNP	G	G	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr1:150129105G>T	ENST00000369124.4	+	4	597	c.318_splice	c.e4-1	p.A107_splice	PLEKHO1_ENST00000479194.1_3'UTR|PLEKHO1_ENST00000369126.1_5'UTR|PLEKHO1_ENST00000025469.6_Splice_Site_p.A107_splice	NM_016274.4	NP_057358.2	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O member 1	107	PH.					cytoplasm|nucleus|plasma membrane				breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|skin(2)	22	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCCCTCACAGGCACCCAACCT	0.478000													10	64					3.07112e-06	3.98758e-05	0.000978159	1	0
POLR2B	5431	broad.mit.edu	37	4	57896547	57896547	+	Silent	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr4:57896547C>T	ENST00000381227.1	+	25	3830	c.3417C>T	c.(3415-3417)ggC>ggT	p.G1139G	POLR2B_ENST00000431623.2_Silent_p.G1064G|POLR2B_ENST00000441246.2_Silent_p.G1132G|POLR2B_ENST00000314595.5_Silent_p.G1139G			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	1139					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					AATGCAGGGGCTGCCGCAATA	0.433000													17	20					0	0	0.000422831	0	0
UBE3B	89910	broad.mit.edu	37	12	109972570	109972570	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr12:109972570G>T	ENST00000342494.3	+	28	3785	c.3190G>T	c.(3190-3192)Ggc>Tgc	p.G1064C	UBE3B_ENST00000434735.2_Missense_Mutation_p.G1064C	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	1064	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CATGAACACGGGCTTTGAACT	0.617000													5	91					0.000602214	0.00746381	0.000602214	1	0
ATR	545	broad.mit.edu	37	3	142176456	142176456	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr3:142176456G>T	ENST00000350721.4	-	45	7766	c.7645C>A	c.(7645-7647)Cct>Act	p.P2549T	ATR_ENST00000383101.3_Missense_Mutation_p.P2485T	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2549	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						CTCATTAAAGGCTCTCGCTGA	0.373000								Other conserved DNA damage response genes					40	38					1.22674e-20	1.70081e-19	0.00195071	1	0
CELF1	10658	broad.mit.edu	37	11	47510570	47510570	+	Silent	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr11:47510570C>T	ENST00000531165.1	-	4	356	c.78G>A	c.(76-78)aaG>aaA	p.K26K	CELF1_ENST00000395292.2_5'UTR|CELF1_ENST00000532048.1_Silent_p.K26K|CELF1_ENST00000361904.3_5'UTR|CELF1_ENST00000395290.2_5'UTR|CELF1_ENST00000310513.5_5'UTR			Q92879	CELF1_HUMAN	CUGBP, Elav-like family member 1	0	RRM 1.				embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)	18						CGTTCATTTTCTTTGAGCTGT	0.403000													7	60					0	0	0.00198382	0	0
NXPH2	11249	broad.mit.edu	37	2	139429083	139429083	+	Silent	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr2:139429083G>A	ENST00000272641.3	-	2	310	c.204C>T	c.(202-204)ccC>ccT	p.P68P		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	68	II.				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		CCATGGGGCCGGGCTTGGGCA	0.552000													52	107					0	0	0.000781405	0	0
EGFR	1956	broad.mit.edu	37	7	55210002	55210002	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr7:55210002C>G	ENST00000275493.2	+	2	289	c.112C>G	c.(112-114)Ctc>Gtc	p.L38V	EGFR_ENST00000342916.3_Missense_Mutation_p.L38V|EGFR_ENST00000442591.1_Missense_Mutation_p.L38V|EGFR_ENST00000454757.2_5'UTR|EGFR_ENST00000420316.2_Missense_Mutation_p.L38V|EGFR_ENST00000344576.2_Missense_Mutation_p.L38V|EGFR_ENST00000455089.1_Missense_Mutation_p.L38V	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	38					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GAGTAACAAGCTCACGCAGTT	0.408000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			33	62					0	0	0.00209593	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	54					0	0	0.00024832	0	0
ENO2	2026	broad.mit.edu	37	12	7025014	7025014	+	Silent	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr12:7025014C>T	ENST00000535366.1	+	1	644	c.18C>T	c.(16-18)atC>atT	p.I6I	ENO2_ENST00000544774.1_Silent_p.I6I|ENO2_ENST00000229277.1_Silent_p.I6I|ENO2_ENST00000541477.1_Silent_p.I6I|ENO2_ENST00000538763.1_Silent_p.I6I|ENO2_ENST00000545045.2_Silent_p.I6I			P09104	ENOG_HUMAN	enolase 2 (gamma, neuronal)	6					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex|plasma membrane	magnesium ion binding|phosphopyruvate hydratase activity			endometrium(3)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						TAGAGAAGATCTGGGCCCGGG	0.577000													64	282					0	0	0.000781405	0	0
PCGF3	10336	broad.mit.edu	37	4	755159	755159	+	Silent	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr4:755159G>A	ENST00000362003.5	+	9	950	c.555G>A	c.(553-555)ctG>ctA	p.L185L	PCGF3_ENST00000505655.2_Silent_p.L185L|PCGF3_ENST00000521023.2_Silent_p.L151L|PCGF3_ENST00000470161.2_Silent_p.L185L	NM_006315.4	NP_006306.2	Q3KNV8	PCGF3_HUMAN	polycomb group ring finger 3	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(1)	7						TCTTGCATCTGAAGAAGTTCA	0.498000													6	67					0	0	0.00116845	0	0
BTNL8	79908	broad.mit.edu	37	5	180335857	180335857	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr5:180335857G>T	ENST00000231229.4	+	2	555	c.321G>T	c.(319-321)ttG>ttT	p.L107F	BTNL8_ENST00000511704.1_Intron|BTNL8_ENST00000508408.1_Missense_Mutation_p.L107F|BTNL8_ENST00000400707.3_Intron|BTNL8_ENST00000340184.4_Missense_Mutation_p.L107F	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	107	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTACTGTGTTGGATGCTGGCC	0.473000													13	207					1.49906e-05	0.000191598	0.00244969	1	0
PCNXL3	399909	broad.mit.edu	37	11	65402557	65402557	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr11:65402557C>T	ENST00000355703.3	+	30	5458	c.4919C>T	c.(4918-4920)gCg>gTg	p.A1640V		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1640						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CGCGTTGTGGCGCCTGGGGTT	0.647000													10	26					0	0	0.000978159	0	0
SARNP	84324	broad.mit.edu	37	12	56182870	56182870	+	Missense_Mutation	SNP	T	T	C	rs138765992		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr12:56182870T>C	ENST00000546837.1	-	14	1426	c.1427A>G	c.(1426-1428)aAt>aGt	p.N476S	SARNP_ENST00000552080.1_Missense_Mutation_p.I164V|SARNP_ENST00000336133.3_Missense_Mutation_p.I164V|SARNP_ENST00000444631.2_Missense_Mutation_p.I104V																							TTTCTGGAGATTGAAGAGACA	0.368000													30	70					0	0	0.001512	0	0
BAGE2	85319	broad.mit.edu	37	21	11058353	11058353	+	RNA	SNP	T	T	C	rs79433933	by1000genomes	TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr21:11058353T>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAAATCTCTTTATAAAACCTT	0.343000													4	89					0	0	0.000602214	0	0
ARMCX2	9823	broad.mit.edu	37	X	100911661	100911661	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chrX:100911661T>C	ENST00000328766.5	-	5	1367	c.914A>G	c.(913-915)gAc>gGc	p.D305G	ARMCX2_ENST00000356824.4_Missense_Mutation_p.D305G|ARMCX2_ENST00000330154.2_Missense_Mutation_p.D305G	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	305						integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						CCCCAGTTCGTCTACTTCAAC	0.587000													64	27					0	0	0.000781405	0	0
HEPACAM	220296	broad.mit.edu	37	11	124794765	124794765	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr11:124794765G>C	ENST00000298251.4	-	2	691	c.286C>G	c.(286-288)Cga>Gga	p.R96G		NM_152722.4	NP_689935.2	Q14CZ8	HECAM_HUMAN	hepatic and glial cell adhesion molecule	96	Ig-like V-type.				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane		p.R96*(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		ATACGGTCTCGATAGTCAGGC	0.592000													45	74					0	0	0.00222228	0	0
STAC2	342667	broad.mit.edu	37	17	37371437	37371437	+	Silent	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr17:37371437G>A	ENST00000333461.5	-	5	1002	c.633C>T	c.(631-633)ggC>ggT	p.G211G		NM_198993.3	NP_945344.1	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	211					intracellular signal transduction		metal ion binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(2)	17						CCAGGGAGGTGCCATAGCGCA	0.592000													32	59					0	0	0.000814825	0	0
BTNL8	79908	broad.mit.edu	37	5	180335874	180335874	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr5:180335874G>T	ENST00000231229.4	+	2	572	c.338G>T	c.(337-339)gGg>gTg	p.G113V	BTNL8_ENST00000511704.1_Intron|BTNL8_ENST00000508408.1_Missense_Mutation_p.G113V|BTNL8_ENST00000400707.3_Intron|BTNL8_ENST00000340184.4_Missense_Mutation_p.G113V	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	113	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCCTCTATGGGTGCAGGATT	0.478000													12	209					0.000151284	0.00190386	0.00185496	1	0
MUC16	94025	broad.mit.edu	37	19	9074800	9074800	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:9074800T>G	ENST00000397910.4	-	3	12849	c.12646A>C	c.(12646-12648)Agt>Cgt	p.S4216R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4218	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAGGTAAACTTGTGCCAGGT	0.498000													11	62					0	0	0.000673444	0	0
ETFDH	2110	broad.mit.edu	37	4	159620266	159620266	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr4:159620266A>G	ENST00000511912.1	+	9	1432	c.1100A>G	c.(1099-1101)aAt>aGt	p.N367S	ETFDH_ENST00000307738.5_Missense_Mutation_p.N320S	NM_004453.2	NP_004444.2	Q16134	ETFD_HUMAN	electron-transferring-flavoprotein dehydrogenase	367					fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|prostate(1)|skin(3)	28	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)		AGAGCTCTCAATGAAGGTGGC	0.378000													16	14					0	0	0.000566183	0	0
RPL36	25873	broad.mit.edu	37	19	5691333	5691333	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:5691333C>G	ENST00000577222.1	+	5	641	c.97C>G	c.(97-99)Ctg>Gtg	p.L33V	RPL36_ENST00000394580.2_Missense_Mutation_p.L33V|RPL36_ENST00000347512.3_Missense_Mutation_p.L33V|RPL36_ENST00000579649.1_Missense_Mutation_p.L33V|RPL36_ENST00000579446.1_Missense_Mutation_p.L33V			Q9Y3U8	RL36_HUMAN	ribosomal protein L36	33					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|structural constituent of ribosome			breast(1)|upper_aerodigestive_tract(1)	2						CCCCTAGCGTCTGACCAAACA	0.602000											OREG0025183	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	68					0	0	0.000953801	0	0
FREM2	341640	broad.mit.edu	37	13	39262438	39262438	+	Silent	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr13:39262438G>A	ENST00000280481.7	+	1	1173	c.957G>A	c.(955-957)aaG>aaA	p.K319K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	319					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CTGCACCCAAGCCCAGTTTCG	0.607000													20	22					0	0	0.00152264	0	0
COL5A3	50509	broad.mit.edu	37	19	10077031	10077031	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:10077031C>T	ENST00000264828.3	-	64	4826	c.4741G>A	c.(4741-4743)Gga>Aga	p.G1581R		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1581	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GTCTCTCCTCCCGCCGTGAAG	0.602000													19	26					0	0	0.00121646	0	0
LINC00969	440993	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													4	21					0	0	0.00024832	0	0
LIPG	9388	broad.mit.edu	37	18	47101893	47101893	+	Silent	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr18:47101893C>T	ENST00000261292.4	+	5	1004	c.726C>T	c.(724-726)taC>taT	p.Y242Y	LIPG_ENST00000580036.1_Silent_p.Y242Y|LIPG_ENST00000577628.1_Silent_p.Y278Y|LIPG_ENST00000427224.2_Intron	NM_006033.2	NP_006024.1	Q9Y5X9	LIPE_HUMAN	lipase, endothelial	242					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(2)	18						TTGACATCTACCCCAATGGGG	0.507000													8	85					0	0	0.000274275	0	0
ZNF449	203523	broad.mit.edu	37	X	134483238	134483238	+	Splice_Site	SNP	T	T	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chrX:134483238T>G	ENST00000339249.4	+	3	698	c.559_splice	c.e3+1	p.P186_splice		NM_152695.5	NP_689908.3	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	186					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					TTCTGGACCCTGGTAAGGCAA	0.512000													16	39					0	0	0.000308642	0	0
OGDH	4967	broad.mit.edu	37	7	44747333	44747333	+	Silent	SNP	C	C	G	rs1135689		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr7:44747333C>G	ENST00000222673.5	+	22	2991	c.2949C>G	c.(2947-2949)gtC>gtG	p.V983V	OGDH_ENST00000543843.1_Silent_p.V934V|OGDH_ENST00000449767.1_Silent_p.V979V|OGDH_ENST00000447398.1_Silent_p.V994V|OGDH_ENST00000444676.1_Silent_p.V998V|OGDH_ENST00000439616.2_Silent_p.V833V	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	983					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	CCAAGCCCGTCTGGTAAGGCT	0.612000													29	52					0	0	0.00106085	0	0
NRAP	4892	broad.mit.edu	37	10	115391662	115391662	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr10:115391662G>A	ENST00000369358.4	-	17	1938	c.1694C>T	c.(1693-1695)gCc>gTc	p.A565V	NRAP_ENST00000360478.3_Missense_Mutation_p.A530V|NRAP_ENST00000359988.3_Missense_Mutation_p.A565V|NRAP_ENST00000369360.3_Missense_Mutation_p.A530V			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	565						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CAGAGACATGGCATCCAGCTT	0.448000													53	74					0	0	0.000781405	0	0
ZSCAN5A	79149	broad.mit.edu	37	19	56732960	56732960	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:56732960T>G	ENST00000587340.1	-	7	2170	c.1475A>C	c.(1474-1476)gAa>gCa	p.E492A	ZSCAN5A_ENST00000391713.1_Missense_Mutation_p.E492A|ZSCAN5A_ENST00000587492.1_Missense_Mutation_p.E346A|ZSCAN5A_ENST00000254165.3_Missense_Mutation_p.E375A|ZSCAN5A_ENST00000592355.1_Missense_Mutation_p.E491A			Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	492					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						AGAAGTAGCTTCTGGATGTGT	0.433000													30	50					0	0	0.0024448	0	0
IGF2BP2	10644	broad.mit.edu	37	3	185363333	185363333	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr3:185363333G>A	ENST00000382199.2	-	16	1881	c.1786C>T	c.(1786-1788)Cag>Tag	p.Q596*	IGF2BP2_ENST00000346192.3_Nonsense_Mutation_p.Q553*|IGF2BP2_ENST00000457616.2_Nonsense_Mutation_p.Q602*|IGF2BP2_ENST00000421047.2_Nonsense_Mutation_p.Q539*	NM_006548.4	NP_006539.3	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding protein 2	596					anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	20	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TTGCTGCGCTGTGAGGCGACT	0.547000													100	46					0	0	0.000781405	0	0
KIF3A	11127	broad.mit.edu	37	5	132037805	132037805	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr5:132037805C>G	ENST00000378746.4	-	13	1995	c.1777G>C	c.(1777-1779)Gat>Cat	p.D593H	KIF3A_ENST00000403231.1_Missense_Mutation_p.D620H|KIF3A_ENST00000487055.1_5'UTR|KIF3A_ENST00000378735.1_Missense_Mutation_p.D596H|AC004237.1_ENST00000431165.1_RNA	NM_007054.5	NP_008985.3	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	593					blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			endometrium(1)|kidney(4)|large_intestine(8)|lung(3)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	25		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATAAAGTTATCAATAATAAGC	0.413000													26	22					0	0	0.000878237	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161926	90161926	+	RNA	SNP	T	T	C	rs8061283	by1000genomes	TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr16:90161926T>C	ENST00000564451.1	+	0	1279				TUBB8P7_ENST00000567960.1_RNA														p.I221T(3)									CCCACACCCATCTATGGTGAC	0.527000													4	40					0	0	0.00116845	0	0
ADCY6	112	broad.mit.edu	37	12	49176996	49176996	+	Silent	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr12:49176996G>A	ENST00000307885.4	-	1	916	c.222C>T	c.(220-222)ggC>ggT	p.G74G	ADCY6_ENST00000550422.1_Silent_p.G74G|ADCY6_ENST00000357869.3_Silent_p.G74G	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	74					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						TGCCTGGGCCGCCCCTCCGGA	0.721000													22	35					0	0	0.00188189	0	0
SERBP1	26135	broad.mit.edu	37	1	67895933	67895933	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr1:67895933G>C	ENST00000370994.4	-	1	165	c.51C>G	c.(49-51)ttC>ttG	p.F17L	SERBP1_ENST00000370990.5_Missense_Mutation_p.F17L|SERBP1_ENST00000361219.6_Missense_Mutation_p.F17L|SERBP1_ENST00000370995.2_Missense_Mutation_p.F17L	NM_001018067.1|NM_001018068.1|NM_001018069.1|NM_015640.3	NP_001018077.1|NP_001018078.1|NP_001018079.1|NP_056455.3	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1	17					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	13						ATAACTGGTCGAATCGGTTGG	0.642000													51	42					0	0	0.000781405	0	0
LILRB5	10990	broad.mit.edu	37	19	54754843	54754843	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:54754843A>G	ENST00000450632.1	-	13	1869	c.1792T>C	c.(1792-1794)Tcc>Ccc	p.S598P	LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000449561.2_Intron|LILRB5_ENST00000316219.5_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	423					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGGGTGGGGAGGCCTGGGGG	0.607000													4	46					0	0	0.00024832	0	0
FAT1	2195	broad.mit.edu	37	4	187517826	187517826	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr4:187517826C>A	ENST00000441802.2	-	25	13077	c.12868G>T	c.(12868-12870)Gag>Tag	p.E4290*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4290					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TGCACAGACTCGGGGTTAAAA	0.557000										HNSCC(5;0.00058)			22	12					8.10497e-08	1.06933e-06	0.00152264	1	0
MIR518D	574489	broad.mit.edu	37	19	54238204	54238204	+	RNA	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:54238204G>A	ENST00000385014.1	+	0	74					NR_030211.1																						CCTTTGGAGCGTTACGGTTTG	0.453000													5	55					0	0	0.000602214	0	0
USP6NL	9712	broad.mit.edu	37	10	11505354	11505354	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr10:11505354C>T	ENST00000379237.1	-	15	1967	c.1573G>A	c.(1573-1575)Gtg>Atg	p.V525M	USP6NL_ENST00000277575.5_Missense_Mutation_p.V542M	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	525						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						GACACCCGCACCTCGGCAGGA	0.622000													50	131					0	0	0.000781405	0	0
EGFLAM	133584	broad.mit.edu	37	5	38464067	38464067	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr5:38464067C>G	ENST00000322350.5	+	22	3355	c.3009C>G	c.(3007-3009)atC>atG	p.I1003M	EGFLAM_ENST00000397210.3_Missense_Mutation_p.I146M|EGFLAM_ENST00000506135.1_Missense_Mutation_p.I146M|EGFLAM_ENST00000397202.2_Missense_Mutation_p.I369M|EGFLAM_ENST00000336740.6_Missense_Mutation_p.I769M|CTD-2263F21.1_ENST00000510469.1_RNA|EGFLAM_ENST00000354891.3_Missense_Mutation_p.I1011M|EGFLAM_ENST00000514476.1_Missense_Mutation_p.I146M	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	1011	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GGAAAAACATCAACACTTGTG	0.527000													7	94					0	0	0.00198382	0	0
PHACTR1	221692	broad.mit.edu	37	6	13230292	13230292	+	Silent	SNP	A	A	C			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr6:13230292A>C	ENST00000379350.1	+	9	1387	c.1258A>C	c.(1258-1260)Agg>Cgg	p.R420R	PHACTR1_ENST00000379345.2_Intron|PHACTR1_ENST00000332995.7_Silent_p.R420R|PHACTR1_ENST00000457702.2_Silent_p.R275R			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	420						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			GAAGGTCTGCAGGAAGGACTC	0.547000													4	6					0	0	0.00024832	0	0
PRSS22	64063	broad.mit.edu	37	16	2905603	2905603	+	Silent	SNP	G	G	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr16:2905603G>T	ENST00000161006.3	-	4	596	c.531C>A	c.(529-531)atC>atA	p.I177I	PRSS22_ENST00000571228.1_Intron	NM_022119.3	NP_071402.1	Q9GZN4	BSSP4_HUMAN	protease, serine, 22	177	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(2)|skin(2)	10						CCCAGCCTGAGATCCAGCAGT	0.602000													14	48					2.61681e-11	3.56759e-10	0.00244969	1	0
IKZF2	22807	broad.mit.edu	37	2	213878609	213878609	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr2:213878609A>C	ENST00000457361.1	-	7	930	c.762T>G	c.(760-762)aaT>aaG	p.N254K	IKZF2_ENST00000413091.3_3'UTR|IKZF2_ENST00000342002.2_Missense_Mutation_p.N260K|IKZF2_ENST00000451136.2_Missense_Mutation_p.N182K|IKZF2_ENST00000434687.1_Missense_Mutation_p.N254K|IKZF2_ENST00000374327.4_Missense_Mutation_p.N109K|IKZF2_ENST00000421754.2_Intron|IKZF2_ENST00000374319.4_Missense_Mutation_p.N228K	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CCAGAGAAATATTGTTGTCCA	0.393000													12	61					0	0	0.00136819	0	0
FRG1BP	284802	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr20:29625941A>T	ENST00000278882.3	+	5	565	c.185A>T	c.(184-186)gAt>gTt	p.D62V	FRG1B_ENST00000439954.2_Missense_Mutation_p.D67V|FRG1B_ENST00000358464.4_Missense_Mutation_p.D62V														p.D62V(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGCATTCAGATGCAATTGGA	0.333000													8	60					0	0	0.000274275	0	0
OPN1LW	5956	broad.mit.edu	37	X	153420103	153420103	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chrX:153420103C>A	ENST00000369951.4	+	4	693	c.633C>A	c.(631-633)agC>agA	p.S211R	OPN1LW_ENST00000463296.1_Intron	NM_020061.4	NP_064445.1	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	211					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	15	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCAGCGGCAGCTCGTACCCCG	0.607000													45	16					2.69953e-25	3.80727e-24	0.000781405	1	0
COL5A3	50509	broad.mit.edu	37	19	10077032	10077032	+	Silent	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:10077032C>T	ENST00000264828.3	-	64	4825	c.4740G>A	c.(4738-4740)gcG>gcA	p.A1580A		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1580	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TCTCTCCTCCCGCCGTGAAGT	0.602000													19	24					0	0	0.00188189	0	0
TEX15	56154	broad.mit.edu	37	8	30705568	30705568	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr8:30705568A>T	ENST00000256246.2	-	1	1040	c.966T>A	c.(964-966)gaT>gaA	p.D322E		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	322										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ATGCTAGATGATCTAGTTCAT	0.343000													13	29					0	0	0.000308642	0	0
GABRA2	2555	broad.mit.edu	37	4	46388201	46388201	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr4:46388201A>G	ENST00000507460.1	-	3	409	c.77T>C	c.(76-78)gTg>gCg	p.V26A	GABRA2_ENST00000540012.1_5'UTR|GABRA2_ENST00000514090.1_Missense_Mutation_p.V26A|GABRA2_ENST00000507069.1_Missense_Mutation_p.V26A|GABRA2_ENST00000510861.1_Missense_Mutation_p.V26A|GABRA2_ENST00000381620.4_Missense_Mutation_p.V26A|GABRA2_ENST00000356504.1_Missense_Mutation_p.V26A|GABRA2_ENST00000515082.1_Missense_Mutation_p.V26A|GABRA2_ENST00000509716.1_5'UTR			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	26					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GTTAGCCAGCACCAACCTAAA	0.343000													9	18					0	0	0.000274275	0	0
AKT2	208	broad.mit.edu	37	19	40740869	40740869	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:40740869C>A	ENST00000579047.1	-	12	1564	c.1263G>T	c.(1261-1263)gaG>gaT	p.E421D	AKT2_ENST00000424901.1_Intron|AKT2_ENST00000311278.6_Intron|AKT2_ENST00000392038.2_Intron			P31751	AKT2_HUMAN	v-akt murine thymoma viral oncogene homolog 2	113	AGC-kinase C-terminal.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|kidney(3)|large_intestine(9)|lung(10)|prostate(2)|skin(1)	27			Lung(22;0.000499)			TTCGAGGGCCCTCCTTGAGAA	0.632000			A		"""ovarian, pancreatic """								7	17					2.7689e-08	3.71304e-07	0.00198382	1	0
ALG3	10195	broad.mit.edu	37	3	183960340	183960340	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr3:183960340A>G	ENST00000455059.1	-	9	1613	c.1159T>C	c.(1159-1161)Ttc>Ctc	p.F387L	ALG3_ENST00000445626.2_Missense_Mutation_p.F379L|EIF2B5_ENST00000444495.1_Intron|ALG3_ENST00000397676.3_Missense_Mutation_p.F427L|ALG3_ENST00000418734.2_Missense_Mutation_p.F371L			Q92685	ALG3_HUMAN	ALG3, alpha-1,3- mannosyltransferase	427					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	9	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTCTTGGGGAAAGGCTGCGGG	0.597000													44	154					0	0	0.00285205	0	0
PRKD3	23683	broad.mit.edu	37	2	37505102	37505102	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr2:37505102C>T	ENST00000379066.1	-	9	1965	c.1203G>A	c.(1201-1203)atG>atA	p.M401I	PRKD3_ENST00000234179.2_Missense_Mutation_p.M401I			O94806	KPCD3_HUMAN	protein kinase D3	401					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				GTACAACCCTCATTAGCGGAA	0.363000													15	99					0	0	0.002450	0	0
NCOR2	9612	broad.mit.edu	37	12	124887093	124887093	+	Silent	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr12:124887093C>T	ENST00000356219.3	-	15	1652	c.1497G>A	c.(1495-1497)caG>caA	p.Q499Q	NCOR2_ENST00000429285.2_Silent_p.Q498Q|NCOR2_ENST00000405201.1_Silent_p.Q499Q|NCOR2_ENST00000404621.1_Silent_p.Q498Q|NCOR2_ENST00000404121.2_Silent_p.Q69Q|NCOR2_ENST00000397355.1_Silent_p.Q499Q	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	499	Poly-Gln.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity	p.Q499Q(9)		breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		gctgctgctgctgttgttgct	0.617000													3	7					0	0	0.004672	0	0
CASZ1	54897	broad.mit.edu	37	1	10714479	10714479	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr1:10714479C>T	ENST00000377022.3	-	10	2152	c.1835G>A	c.(1834-1836)tGc>tAc	p.C612Y	CASZ1_ENST00000344008.5_Missense_Mutation_p.C612Y	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	612					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CGCTTACCTGCAGTGGAAGTG	0.652000													24	51					0	0	0.002299	0	0
BLNK	29760	broad.mit.edu	37	10	97987176	97987176	+	Silent	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr10:97987176G>A	ENST00000224337.5	-	5	492	c.351C>T	c.(349-351)ggC>ggT	p.G117G	BLNK_ENST00000413476.2_Silent_p.G117G|BLNK_ENST00000427367.2_Silent_p.G117G|BLNK_ENST00000371176.2_Silent_p.G117G	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	117	Pro-rich.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		CTATATACTCGCCTCTGGCGA	0.652000													35	61					0	0	0.003271	0	0
ABO	28	broad.mit.edu	37	9	136132874	136132874	+	RNA	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr9:136132874G>A	ENST00000453660.2	-	0	306							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		GATGTTGAATGTGCCCTCCCA	0.557000													33	38					0	0	0.002096	0	0
ZSCAN5A	79149	broad.mit.edu	37	19	56732960	56732960	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr19:56732960T>G	ENST00000587340.1	-	7	2170	c.1475A>C	c.(1474-1476)gAa>gCa	p.E492A	ZSCAN5A_ENST00000254165.3_Missense_Mutation_p.E375A|ZSCAN5A_ENST00000592355.1_Missense_Mutation_p.E491A|ZSCAN5A_ENST00000587492.1_Missense_Mutation_p.E346A|ZSCAN5A_ENST00000391713.1_Missense_Mutation_p.E492A			Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	492					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						AGAAGTAGCTTCTGGATGTGT	0.433000													30	50					0	0	0.002445	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728546	20728546	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr19:20728546G>C	ENST00000427401.4	-	4	557	c.463C>G	c.(463-465)Cat>Gat	p.H155D		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	155					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						GAAAATTTATGAATGACTTTC	0.308000													17	29					0	0	0.004007	0	0
PKM	5315	broad.mit.edu	37	15	72501133	72501133	+	Missense_Mutation	SNP	G	G	A	rs143294717		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr15:72501133G>A	ENST00000319622.6	-	6	1121	c.665C>T	c.(664-666)tCg>tTg	p.S222L	PKM_ENST00000449901.2_Missense_Mutation_p.S207L|PKM_ENST00000568459.1_Missense_Mutation_p.S222L|PKM_ENST00000389093.3_Missense_Mutation_p.S222L|PKM_ENST00000568883.1_Missense_Mutation_p.S57L|PKM_ENST00000565154.1_Missense_Mutation_p.S222L|PKM_ENST00000335181.5_Missense_Mutation_p.S222L|PKM_ENST00000565184.1_Missense_Mutation_p.S222L	NM_001206796.1|NM_182470.2|NM_182471.2	NP_001193725.1|NP_872270.1|NP_872271.1			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						GTCCTTCTCCGACACAGCAGG	0.547000													36	78					0	0	0.004289	0	0
PLEKHO1	51177	broad.mit.edu	37	1	150129105	150129105	+	Splice_Site	SNP	G	G	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr1:150129105G>T	ENST00000369124.4	+	4	597	c.318_splice	c.e4-1	p.A107_splice	PLEKHO1_ENST00000479194.1_3'UTR|PLEKHO1_ENST00000025469.6_Splice_Site_p.A107_splice|PLEKHO1_ENST00000369126.1_5'UTR	NM_016274.4	NP_057358.2	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O member 1	107	PH.					cytoplasm|nucleus|plasma membrane				breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|skin(2)	22	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCCCTCACAGGCACCCAACCT	0.478000													10	64					3.07112e-06	4.97646e-05	0.000978	1	0
POLR2B	5431	broad.mit.edu	37	4	57896547	57896547	+	Silent	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr4:57896547C>T	ENST00000381227.1	+	25	3830	c.3417C>T	c.(3415-3417)ggC>ggT	p.G1139G	POLR2B_ENST00000314595.5_Silent_p.G1139G|POLR2B_ENST00000441246.2_Silent_p.G1132G|POLR2B_ENST00000431623.2_Silent_p.G1064G			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	1139					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					AATGCAGGGGCTGCCGCAATA	0.433000													17	20					0	0	0.004007	0	0
UBE3B	89910	broad.mit.edu	37	12	109972570	109972570	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr12:109972570G>T	ENST00000342494.3	+	28	3785	c.3190G>T	c.(3190-3192)Ggc>Tgc	p.G1064C	UBE3B_ENST00000434735.2_Missense_Mutation_p.G1064C	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	1064	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CATGAACACGGGCTTTGAACT	0.617000													5	91					0.000602214	0.00919535	0.000602	1	0
ATR	545	broad.mit.edu	37	3	142176456	142176456	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr3:142176456G>T	ENST00000350721.4	-	45	7766	c.7645C>A	c.(7645-7647)Cct>Act	p.P2549T	ATR_ENST00000383101.3_Missense_Mutation_p.P2485T	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2549	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						CTCATTAAAGGCTCTCGCTGA	0.373000								Other conserved DNA damage response genes					40	38					1.22674e-20	2.11747e-19	0.001951	1	0
CELF1	10658	broad.mit.edu	37	11	47510570	47510570	+	Silent	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr11:47510570C>T	ENST00000531165.1	-	4	356	c.78G>A	c.(76-78)aaG>aaA	p.K26K	CELF1_ENST00000532048.1_Silent_p.K26K|CELF1_ENST00000395290.2_5'UTR|CELF1_ENST00000361904.3_5'UTR|CELF1_ENST00000395292.2_5'UTR|CELF1_ENST00000310513.5_5'UTR			Q92879	CELF1_HUMAN	CUGBP, Elav-like family member 1	0	RRM 1.				embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)	18						CGTTCATTTTCTTTGAGCTGT	0.403000													7	60					0	0	0.001984	0	0
NXPH2	11249	broad.mit.edu	37	2	139429083	139429083	+	Silent	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr2:139429083G>A	ENST00000272641.3	-	2	310	c.204C>T	c.(202-204)ccC>ccT	p.P68P		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	68	II.				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		CCATGGGGCCGGGCTTGGGCA	0.552000													52	107					0	0	0.003610	0	0
ENO2	2026	broad.mit.edu	37	12	7025014	7025014	+	Silent	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr12:7025014C>T	ENST00000535366.1	+	1	644	c.18C>T	c.(16-18)atC>atT	p.I6I	ENO2_ENST00000229277.1_Silent_p.I6I|ENO2_ENST00000545045.2_Silent_p.I6I|ENO2_ENST00000544774.1_Silent_p.I6I|ENO2_ENST00000538763.1_Silent_p.I6I|ENO2_ENST00000541477.1_Silent_p.I6I			P09104	ENOG_HUMAN	enolase 2 (gamma, neuronal)	6					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex|plasma membrane	magnesium ion binding|phosphopyruvate hydratase activity			endometrium(3)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						TAGAGAAGATCTGGGCCCGGG	0.577000													64	282					0	0	0.003610	0	0
PCGF3	10336	broad.mit.edu	37	4	755159	755159	+	Silent	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr4:755159G>A	ENST00000362003.5	+	9	950	c.555G>A	c.(553-555)ctG>ctA	p.L185L	PCGF3_ENST00000521023.2_Silent_p.L151L|PCGF3_ENST00000470161.2_Silent_p.L185L|PCGF3_ENST00000505655.2_Silent_p.L185L	NM_006315.4	NP_006306.2	Q3KNV8	PCGF3_HUMAN	polycomb group ring finger 3	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(1)	7						TCTTGCATCTGAAGAAGTTCA	0.498000													6	67					0	0	0.001168	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659621	24659621	+	RNA	SNP	T	T	C	rs116751564	by1000genomes	TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr22:24659621T>C	ENST00000414583.2	+	0	3146					NR_003714.1																						CCTGGATGTCTGCGGCCACAC	0.637000													5	25					0	0	0.000602	0	0
BTNL8	79908	broad.mit.edu	37	5	180335857	180335857	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr5:180335857G>T	ENST00000231229.4	+	2	555	c.321G>T	c.(319-321)ttG>ttT	p.L107F	BTNL8_ENST00000508408.1_Missense_Mutation_p.L107F|BTNL8_ENST00000340184.4_Missense_Mutation_p.L107F|BTNL8_ENST00000400707.3_Intron|BTNL8_ENST00000511704.1_Intron	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	107	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTACTGTGTTGGATGCTGGCC	0.473000													13	207					1.49906e-05	0.000238051	0.002450	1	0
SARNP	84324	broad.mit.edu	37	12	56182870	56182870	+	Missense_Mutation	SNP	T	T	C	rs138765992		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr12:56182870T>C	ENST00000546837.1	-	14	1426	c.1427A>G	c.(1426-1428)aAt>aGt	p.N476S	SARNP_ENST00000444631.2_Missense_Mutation_p.I104V|SARNP_ENST00000336133.3_Missense_Mutation_p.I164V|SARNP_ENST00000552080.1_Missense_Mutation_p.I164V																							TTTCTGGAGATTGAAGAGACA	0.368000													30	70					0	0	0.001512	0	0
STAC2	342667	broad.mit.edu	37	17	37371437	37371437	+	Silent	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr17:37371437G>A	ENST00000333461.5	-	5	1002	c.633C>T	c.(631-633)ggC>ggT	p.G211G		NM_198993.3	NP_945344.1	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	211					intracellular signal transduction		metal ion binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(2)	17						CCAGGGAGGTGCCATAGCGCA	0.592000													32	59					0	0	0.004289	0	0
BTNL8	79908	broad.mit.edu	37	5	180335874	180335874	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr5:180335874G>T	ENST00000231229.4	+	2	572	c.338G>T	c.(337-339)gGg>gTg	p.G113V	BTNL8_ENST00000508408.1_Missense_Mutation_p.G113V|BTNL8_ENST00000340184.4_Missense_Mutation_p.G113V|BTNL8_ENST00000400707.3_Intron|BTNL8_ENST00000511704.1_Intron	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	113	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCCTCTATGGGTGCAGGATT	0.478000													12	209					0.000151284	0.00235529	0.001855	1	0
MUC16	94025	broad.mit.edu	37	19	9074800	9074800	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr19:9074800T>G	ENST00000397910.4	-	3	12849	c.12646A>C	c.(12646-12648)Agt>Cgt	p.S4216R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4218	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAGGTAAACTTGTGCCAGGT	0.498000													11	62					0	0	0.000673	0	0
ETFDH	2110	broad.mit.edu	37	4	159620266	159620266	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr4:159620266A>G	ENST00000511912.1	+	9	1432	c.1100A>G	c.(1099-1101)aAt>aGt	p.N367S	ETFDH_ENST00000307738.5_Missense_Mutation_p.N320S	NM_004453.2	NP_004444.2	Q16134	ETFD_HUMAN	electron-transferring-flavoprotein dehydrogenase	367					fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|prostate(1)|skin(3)	28	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)		AGAGCTCTCAATGAAGGTGGC	0.378000													16	14					0	0	0.004990	0	0
RPL36	25873	broad.mit.edu	37	19	5691333	5691333	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr19:5691333C>G	ENST00000577222.1	+	5	641	c.97C>G	c.(97-99)Ctg>Gtg	p.L33V	RPL36_ENST00000347512.3_Missense_Mutation_p.L33V|RPL36_ENST00000579649.1_Missense_Mutation_p.L33V|RPL36_ENST00000394580.2_Missense_Mutation_p.L33V|RPL36_ENST00000579446.1_Missense_Mutation_p.L33V			Q9Y3U8	RL36_HUMAN	ribosomal protein L36	33					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|structural constituent of ribosome			breast(1)|upper_aerodigestive_tract(1)	2						CCCCTAGCGTCTGACCAAACA	0.602000											OREG0025183	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	68					0	0	0.004878	0	0
FREM2	341640	broad.mit.edu	37	13	39262438	39262438	+	Silent	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr13:39262438G>A	ENST00000280481.7	+	1	1173	c.957G>A	c.(955-957)aaG>aaA	p.K319K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	319					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CTGCACCCAAGCCCAGTTTCG	0.607000													20	22					0	0	0.001523	0	0
COL5A3	50509	broad.mit.edu	37	19	10077031	10077031	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr19:10077031C>T	ENST00000264828.3	-	64	4826	c.4741G>A	c.(4741-4743)Gga>Aga	p.G1581R		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1581	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GTCTCTCCTCCCGCCGTGAAG	0.602000													19	26					0	0	0.001216	0	0
LIPG	9388	broad.mit.edu	37	18	47101893	47101893	+	Silent	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr18:47101893C>T	ENST00000261292.4	+	5	1004	c.726C>T	c.(724-726)taC>taT	p.Y242Y	LIPG_ENST00000580036.1_Silent_p.Y242Y|LIPG_ENST00000577628.1_Silent_p.Y278Y|LIPG_ENST00000427224.2_Intron	NM_006033.2	NP_006024.1	Q9Y5X9	LIPE_HUMAN	lipase, endothelial	242					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(2)	18						TTGACATCTACCCCAATGGGG	0.507000													8	85					0	0	0.004482	0	0
ZNF449	203523	broad.mit.edu	37	X	134483238	134483238	+	Splice_Site	SNP	T	T	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chrX:134483238T>G	ENST00000339249.4	+	3	698	c.559_splice	c.e3+1	p.P186_splice		NM_152695.5	NP_689908.3	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	186					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					TTCTGGACCCTGGTAAGGCAA	0.512000													16	39					0	0	0.003163	0	0
OGDH	4967	broad.mit.edu	37	7	44747333	44747333	+	Silent	SNP	C	C	G	rs1135689		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr7:44747333C>G	ENST00000222673.5	+	22	2991	c.2949C>G	c.(2947-2949)gtC>gtG	p.V983V	OGDH_ENST00000543843.1_Silent_p.V934V|OGDH_ENST00000444676.1_Silent_p.V998V|OGDH_ENST00000439616.2_Silent_p.V833V|OGDH_ENST00000449767.1_Silent_p.V979V|OGDH_ENST00000447398.1_Silent_p.V994V	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	983					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	CCAAGCCCGTCTGGTAAGGCT	0.612000													29	52					0	0	0.006320	0	0
NRAP	4892	broad.mit.edu	37	10	115391662	115391662	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr10:115391662G>A	ENST00000369358.4	-	17	1938	c.1694C>T	c.(1693-1695)gCc>gTc	p.A565V	NRAP_ENST00000369360.3_Missense_Mutation_p.A530V|NRAP_ENST00000359988.3_Missense_Mutation_p.A565V|NRAP_ENST00000360478.3_Missense_Mutation_p.A530V			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	565						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CAGAGACATGGCATCCAGCTT	0.448000													53	74					0	0	0.003610	0	0
IGF2BP2	10644	broad.mit.edu	37	3	185363333	185363333	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr3:185363333G>A	ENST00000382199.2	-	16	1881	c.1786C>T	c.(1786-1788)Cag>Tag	p.Q596*	IGF2BP2_ENST00000346192.3_Nonsense_Mutation_p.Q553*|IGF2BP2_ENST00000457616.2_Nonsense_Mutation_p.Q602*|IGF2BP2_ENST00000421047.2_Nonsense_Mutation_p.Q539*	NM_006548.4	NP_006539.3	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding protein 2	596					anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	20	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TTGCTGCGCTGTGAGGCGACT	0.547000													100	46					0	0	0.003610	0	0
KIF3A	11127	broad.mit.edu	37	5	132037805	132037805	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr5:132037805C>G	ENST00000378746.4	-	13	1995	c.1777G>C	c.(1777-1779)Gat>Cat	p.D593H	KIF3A_ENST00000487055.1_5'UTR|KIF3A_ENST00000378735.1_Missense_Mutation_p.D596H|AC004237.1_ENST00000431165.1_RNA|KIF3A_ENST00000403231.1_Missense_Mutation_p.D620H	NM_007054.5	NP_008985.3	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	593					blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			endometrium(1)|kidney(4)|large_intestine(8)|lung(3)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	25		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATAAAGTTATCAATAATAAGC	0.413000													26	22					0	0	0.005443	0	0
KRTAP9-9	81870	broad.mit.edu	37	17	39411940	39411940	+	Silent	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr17:39411940C>T	ENST00000394008.1	+	1	305	c.303C>T	c.(301-303)ggC>ggT	p.G101G		NM_030975.2	NP_112237.2	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	101						keratin filament				endometrium(3)|skin(2)|upper_aerodigestive_tract(1)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CCAGCTGTGGCCAGAGCAGCT	0.617000													6	137					0	0	0.001168	0	0
SERBP1	26135	broad.mit.edu	37	1	67895933	67895933	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr1:67895933G>C	ENST00000370994.4	-	1	165	c.51C>G	c.(49-51)ttC>ttG	p.F17L	SERBP1_ENST00000370990.5_Missense_Mutation_p.F17L|SERBP1_ENST00000361219.6_Missense_Mutation_p.F17L|SERBP1_ENST00000370995.2_Missense_Mutation_p.F17L	NM_001018067.1|NM_001018068.1|NM_001018069.1|NM_015640.3	NP_001018077.1|NP_001018078.1|NP_001018079.1|NP_056455.3	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1	17					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	13						ATAACTGGTCGAATCGGTTGG	0.642000													51	42					0	0	0.003610	0	0
FAT1	2195	broad.mit.edu	37	4	187517826	187517826	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr4:187517826C>A	ENST00000441802.2	-	25	13077	c.12868G>T	c.(12868-12870)Gag>Tag	p.E4290*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4290					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TGCACAGACTCGGGGTTAAAA	0.557000										HNSCC(5;0.00058)			22	12					8.10497e-08	1.3407e-06	0.001523	1	0
MIR518D	574489	broad.mit.edu	37	19	54238204	54238204	+	RNA	SNP	G	G	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr19:54238204G>A	ENST00000385014.1	+	0	74					NR_030211.1																						CCTTTGGAGCGTTACGGTTTG	0.453000													5	55					0	0	0.000602	0	0
EGFLAM	133584	broad.mit.edu	37	5	38464067	38464067	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr5:38464067C>G	ENST00000322350.5	+	22	3355	c.3009C>G	c.(3007-3009)atC>atG	p.I1003M	EGFLAM_ENST00000397210.3_Missense_Mutation_p.I146M|EGFLAM_ENST00000336740.6_Missense_Mutation_p.I769M|EGFLAM_ENST00000514476.1_Missense_Mutation_p.I146M|CTD-2263F21.1_ENST00000510469.1_RNA|EGFLAM_ENST00000506135.1_Missense_Mutation_p.I146M|EGFLAM_ENST00000397202.2_Missense_Mutation_p.I369M|EGFLAM_ENST00000354891.3_Missense_Mutation_p.I1011M	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	1011	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GGAAAAACATCAACACTTGTG	0.527000													7	94					0	0	0.001984	0	0
PHACTR1	221692	broad.mit.edu	37	6	13230292	13230292	+	Silent	SNP	A	A	C			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr6:13230292A>C	ENST00000379350.1	+	9	1387	c.1258A>C	c.(1258-1260)Agg>Cgg	p.R420R	PHACTR1_ENST00000379345.2_Intron|PHACTR1_ENST00000332995.7_Silent_p.R420R|PHACTR1_ENST00000457702.2_Silent_p.R275R			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	420						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			GAAGGTCTGCAGGAAGGACTC	0.547000													4	6					0	0	0.000248	0	0
IKZF2	22807	broad.mit.edu	37	2	213878609	213878609	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr2:213878609A>C	ENST00000457361.1	-	7	930	c.762T>G	c.(760-762)aaT>aaG	p.N254K	IKZF2_ENST00000451136.2_Missense_Mutation_p.N182K|IKZF2_ENST00000342002.2_Missense_Mutation_p.N260K|IKZF2_ENST00000413091.3_3'UTR|IKZF2_ENST00000374319.4_Missense_Mutation_p.N228K|IKZF2_ENST00000421754.2_Intron|IKZF2_ENST00000374327.4_Missense_Mutation_p.N109K|IKZF2_ENST00000434687.1_Missense_Mutation_p.N254K	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CCAGAGAAATATTGTTGTCCA	0.393000													12	61					0	0	0.001368	0	0
COL5A3	50509	broad.mit.edu	37	19	10077032	10077032	+	Silent	SNP	C	C	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr19:10077032C>T	ENST00000264828.3	-	64	4825	c.4740G>A	c.(4738-4740)gcG>gcA	p.A1580A		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1580	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TCTCTCCTCCCGCCGTGAAGT	0.602000													19	24					0	0	0.001882	0	0
TEX15	56154	broad.mit.edu	37	8	30705568	30705568	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr8:30705568A>T	ENST00000256246.2	-	1	1040	c.966T>A	c.(964-966)gaT>gaA	p.D322E		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	322										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ATGCTAGATGATCTAGTTCAT	0.343000													13	29					0	0	0.003163	0	0
NWD1	284434	broad.mit.edu	37	19	16902349	16902349	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr19:16902349C>G	ENST00000524140.2	+	14	3547	c.3129C>G	c.(3127-3129)atC>atG	p.I1043M	NWD1_ENST00000552788.1_Missense_Mutation_p.I1043M|NWD1_ENST00000549814.1_Missense_Mutation_p.I1043M|NWD1_ENST00000379808.3_Missense_Mutation_p.I1043M|NWD1_ENST00000523826.1_Missense_Mutation_p.I837M|NWD1_ENST00000339803.6_Missense_Mutation_p.I908M	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1043							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TGTCCAGCATCAAAGAAGAAA	0.517000													34	69					0	0	0.002445	0	0
AKT2	208	broad.mit.edu	37	19	40740869	40740869	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr19:40740869C>A	ENST00000579047.1	-	12	1564	c.1263G>T	c.(1261-1263)gaG>gaT	p.E421D	AKT2_ENST00000311278.6_Intron|AKT2_ENST00000424901.1_Intron|AKT2_ENST00000392038.2_Intron			P31751	AKT2_HUMAN	v-akt murine thymoma viral oncogene homolog 2	113	AGC-kinase C-terminal.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|kidney(3)|large_intestine(9)|lung(10)|prostate(2)|skin(1)	27			Lung(22;0.000499)			TTCGAGGGCCCTCCTTGAGAA	0.632000			A		"""ovarian, pancreatic """								7	17					2.7689e-08	4.67767e-07	0.001984	1	0
RAD54L	8438	broad.mit.edu	37	1	46726555	46726556	+	Frame_Shift_Ins	INS	-	-	AC			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr1:46726555_46726556insAC	ENST00000371975.4	+	7	1308_1309	c.634_635insAC	c.(634-636)caafs	p.Q212fs	RAD54L_ENST00000442598.1_Frame_Shift_Ins_p.Q212fs	NM_003579.3	NP_003570.2	Q92698	RAD54_HUMAN	RAD54-like (S. cerevisiae)	212	Helicase ATP-binding.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	25	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		GCCAGAAATTGACAAGGCAGTG	0.535								Direct reversal of damage;Homologous recombination					30	68	---	---	---	---					
FGD5P1	100132526	broad.mit.edu	37	3	13978444	13978445	+	RNA	INS	-	-	A	rs11301897	by1000genomes	TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr3:13978444_13978445insA	ENST00000502451.1	+	0	3377					NR_036481.1																						gactccatctcaaaaaaaaaag	0.505													2	4	---	---	---	---					
TMEM41A	90407	broad.mit.edu	37	3	185212517	185212518	+	Frame_Shift_Ins	INS	-	-	A	rs150885877	byFrequency	TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr3:185212517_185212518insA	ENST00000421852.1	-	4	562_563	c.467_468insT	c.(466-468)tttfs	p.F156fs	TMEM41A_ENST00000475480.1_5'UTR|TMEM41A_ENST00000296254.3_Intron	NM_080652.3	NP_542383.1	Q96HV5	TM41A_HUMAN	transmembrane protein 41A	156						integral to membrane				large_intestine(1)|lung(2)|skin(1)	4	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAAACAATAAGAAAAAAAACAA	0.446													7	671	---	---	---	---					
ANKH	56172	broad.mit.edu	37	5	14716943	14716944	+	Splice_Site	INS	-	-	G			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr5:14716943_14716944insG	ENST00000284268.6	-	9	1342_1343	c.1011_splice	c.e9-1	p.L338_splice	ANKH_ENST00000535119.1_Splice_Site_p.L140_splice	NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	338					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						CACGAAACAGAGCTGGGGAGAA	0.455													17	23	---	---	---	---					
DOPEY1	23033	broad.mit.edu	37	6	83866921	83866941	+	In_Frame_Del	DEL	CGTTTGCCACAGGTGCCAACT	CGTTTGCCACAGGTGCCAACT	-			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr6:83866921_83866941delCGTTTGCCACAGGTGCCAACT	ENST00000349129.2	+	35	6885_6905	c.6625_6645delCGTTTGCCACAGGTGCCAACT	c.(6625-6645)del	p.RLPQVPT2209del	DOPEY1_ENST00000369739.3_In_Frame_Del_p.RLPQVPT2200del|DOPEY1_ENST00000237163.5_Intron|DOPEY1_ENST00000484282.1_3'UTR	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	2209					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TGAGAGTCTCCGTTTGCCACAGGTGCCAACTCTCCATTCTC	0.389													9	70	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578471	7578478	+	Frame_Shift_Del	DEL	GGGCGGGG	GGGCGGGG	-	rs137852790		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr17:7578471_7578478delGGGCGGGG	ENST00000420246.2	-	5	584_591	c.452_459delCCCCGCCC	c.(451-459)cfs	p.PPP151fs	TP53_ENST00000413465.2_Frame_Shift_Del_p.PPP151fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.PPP151fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.PPP151fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.PPP151fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.PPP151fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	151	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> A (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934874).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P152L(66)|p.P151H(31)|p.P152S(22)|p.P151P(12)|p.P153fs*28(11)|p.P151R(9)|p.P152R(8)|p.P153S(8)|p.0?(8)|p.P152T(7)|p.P151L(7)|p.P152fs*18(7)|p.P153P(7)|p.T150fs*16(6)|p.P153L(6)|p.P152fs*29(5)|p.P152P(5)|p.?(5)|p.P152fs*14(5)|p.P152Q(4)|p.P153T(3)|p.G154fs*27(3)|p.P59L(2)|p.G154fs*16(2)|p.P58H(2)|p.P152fs*28(2)|p.P20L(2)|p.P153fs*26(2)|p.P153fs*22(2)|p.P152A(2)|p.P19H(2)|p.P153fs*16(1)|p.P151_V173del23(1)|p.T150_P153delTPPP(1)|p.P58R(1)|p.P151del(1)|p.P152fs*27(1)|p.P20R(1)|p.P59R(1)|p.P151fs*30(1)|p.T57fs*16(1)|p.D148_T155delDSTPPPGT(1)|p.P153fs*20(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P19R(1)|p.P152_P153insXXX(1)|p.Q144fs*16(1)|p.P153_G154insX(1)|p.P153F(1)|p.T18fs*16(1)|p.P153A(1)|p.T150_P151delTP(1)|p.P153H(1)|p.P152_P153del(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGCGGGTGCCGGGCGGGGGTGTGGAATC	0.606		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	30	---	---	---	---					
NUDT11	55190	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			4	2	---	---	---	---					
MED15P9	285103	broad.mit.edu	37	2	130893080	130893081	+	RNA	INS	-	-	A			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr2:130893080_130893081insA	ENST00000427638.1	+	0	541_542					NR_033903.1																						gactccatctcaaaaaaaaaaa	0.564													3	5	---	---	---	---					
FGD5P1	100132526	broad.mit.edu	37	3	13978444	13978445	+	RNA	INS	-	-	A	rs11301897	by1000genomes	TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr3:13978444_13978445insA	ENST00000502451.1	+	0	3377					NR_036481.1																						gactccatctcaaaaaaaaaag	0.505													2	4	---	---	---	---					
B3GNT5	84002	broad.mit.edu	37	3	182987673	182987674	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr3:182987673_182987674insT	ENST00000326505.3	+	2	617_618	c.87_88insT	c.(85-90)atttttfs	p.IF29fs	B3GNT5_ENST00000465010.1_Frame_Shift_Ins_p.IF29fs|MCF2L2_ENST00000447025.2_Intron|B3GNT5_ENST00000460419.1_Frame_Shift_Ins_p.IF29fs|MCF2L2_ENST00000328913.3_Intron|MCF2L2_ENST00000473233.1_Intron	NM_032047.4	NP_114436.1	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	29					central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CGAGCCTCATGTTTTTTTGGGA	0.356													7	824	---	---	---	---					
