Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CEP44	80817	broad.mit.edu	37	4	175220309	175220309	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr4:175220309C>G	ENST00000503780.1	+	3	451	c.37C>G	c.(37-39)Cta>Gta	p.L13V	CEP44_ENST00000296519.4_Missense_Mutation_p.L13V|CEP44_ENST00000457424.2_Missense_Mutation_p.L13V|CEP44_ENST00000426172.1_Missense_Mutation_p.L13V	NM_001040157.2	NP_001035247.1	Q9C0F1	CEP44_HUMAN	centrosomal protein 44kDa	13						centrosome|midbody|spindle pole				endometrium(2)|large_intestine(4)|lung(5)|stomach(1)	12						CTTACGGAACCTAGAACAGGT	0.363000													4	36					0	0	1	0	0
ARHGAP28	79822	broad.mit.edu	37	18	6870608	6870608	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr18:6870608G>C	ENST00000419673.2	+	6	571	c.354G>C	c.(352-354)aaG>aaC	p.K118N	ARHGAP28_ENST00000418986.1_Missense_Mutation_p.K118N|ARHGAP28_ENST00000532996.1_Missense_Mutation_p.K100N|ARHGAP28_ENST00000531294.1_Missense_Mutation_p.K113N|ARHGAP28_ENST00000400091.2_Missense_Mutation_p.K277N|ARHGAP28_ENST00000314319.3_Missense_Mutation_p.K118N|ARHGAP28_ENST00000262227.3_Missense_Mutation_p.K225N|ARHGAP28_ENST00000383472.4_Missense_Mutation_p.K277N	NM_001010000.2	NP_001010000.1	B4DXL2	B4DXL2_HUMAN	Rho GTPase activating protein 28	100					signal transduction	intracellular				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	37		Colorectal(10;0.168)				TTCTGGAAAAGAACATTCCAC	0.294000													4	65					0	0	1	0	0
SLC17A6	57084	broad.mit.edu	37	11	22387132	22387132	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:22387132T>A	ENST00000263160.3	+	7	1225	c.788T>A	c.(787-789)gTg>gAg	p.V263E		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	263					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						TGGCTTTTGGTGTCTTATGAA	0.403000													8	57					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113649233	113649233	+	Splice_Site	SNP	T	T	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr8:113649233T>G	ENST00000297405.5	-	22	3772	c.3526_splice	c.e22-1	p.E1176_splice	CSMD3_ENST00000455883.2_Splice_Site_p.E1072_splice|CSMD3_ENST00000343508.3_Splice_Site_p.E1136_splice|CSMD3_ENST00000352409.3_Splice_Site_p.E1176_splice	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1176	CUB 6.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CAAGGTTATATTCTGTAAATT	0.393000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	84					0	0	1	0	0
KPNA5	3841	broad.mit.edu	37	6	117043403	117043403	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr6:117043403C>G	ENST00000368564.1	+	9	1019	c.871C>G	c.(871-873)Caa>Gaa	p.Q291E	KPNA5_ENST00000356348.1_Missense_Mutation_p.Q291E			O15131	IMA5_HUMAN	karyopherin alpha 5 (importin alpha 6)	288					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(6)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		TGATAAAATTCAAGCAGTCAT	0.368000													3	37					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374822	8374822	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr12:8374822G>C	ENST00000538603.1	-	7	1549	c.991C>G	c.(991-993)Ctc>Gtc	p.L331V	FAM90A1_ENST00000307435.6_Missense_Mutation_p.L331V	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	331							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		GGAGGTTGGAGATTCTCCGGG	0.647000													6	22					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45399636	45399636	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr15:45399636C>G	ENST00000389039.6	-	14	1985	c.1600G>C	c.(1600-1602)Gac>Cac	p.D534H	DUOX2_ENST00000603300.1_Missense_Mutation_p.D534H			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	534	Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TTTCGGATGTCTTCAATCTCC	0.552000													11	87					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139165053	139165053	+	Silent	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr8:139165053G>A	ENST00000395297.1	-	13	1835	c.1665C>T	c.(1663-1665)gaC>gaT	p.D555D		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	555										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TAGATTTTACGTCAATGTAGG	0.488000										HNSCC(54;0.14)			18	73					0	0	1	0	0
SETDB1	9869	broad.mit.edu	37	1	150916415	150916415	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:150916415G>T	ENST00000271640.5	+	8	1085	c.895G>T	c.(895-897)Gat>Tat	p.D299Y	SETDB1_ENST00000368962.2_Missense_Mutation_p.D299Y|SETDB1_ENST00000368969.4_Missense_Mutation_p.D299Y|SETDB1_ENST00000459773.1_Intron|SETDB1_ENST00000368963.1_Missense_Mutation_p.231_231insI	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	299	Tudor 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TTTCTTTGATGATGGCTATGC	0.398000													4	84					0.184627	0.186042	1	1	0
POP1	10940	broad.mit.edu	37	8	99170478	99170478	+	Silent	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr8:99170478G>A	ENST00000401707.2	+	16	3135	c.3054G>A	c.(3052-3054)gcG>gcA	p.A1018A	POP1_ENST00000349693.3_Silent_p.A1018A	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	1018					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			ATCGATTTGCGAGGATTGCTA	0.507000													7	127					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33960196	33960196	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:33960196C>G	ENST00000361328.3	+	8	2405	c.2252C>G	c.(2251-2253)tCt>tGt	p.S751C		NM_145238.3	NP_660281.2	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	751					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AGTGACCGCTCTAACCTCAAT	0.458000													7	94					0	0	1	0	0
OR1L6	392390	broad.mit.edu	37	9	125512513	125512513	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr9:125512513C>T	ENST00000373684.1	+	1	495	c.495C>T	c.(493-495)aaC>aaT	p.N165N	OR1L6_ENST00000304720.2_Silent_p.N129N			Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						CCATCTGCAACCCCTTACACT	0.542000													9	114					0	0	1	0	0
WDR63	126820	broad.mit.edu	37	1	85559220	85559220	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:85559220A>T	ENST00000294664.6	+	9	1117	c.937A>T	c.(937-939)Acc>Tcc	p.T313S	WDR63_ENST00000326813.8_Missense_Mutation_p.T274S|WDR63_ENST00000370596.1_Missense_Mutation_p.T274S	NM_145172.3	NP_660155.2	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	313										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)	36				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		AGAAGAAGGCACCTTTGGGGA	0.413000													5	68					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51621457	51621457	+	Silent	SNP	T	T	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr8:51621457T>C	ENST00000522124.1	+	17	1864	c.1203T>C	c.(1201-1203)taT>taC	p.Y401Y	SNTG1_ENST00000518864.1_Silent_p.Y401Y|SNTG1_ENST00000517473.1_Silent_p.Y401Y|SNTG1_ENST00000276467.5_Silent_p.Y401Y	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	401					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GCAAGACCTATGCATGTGTGC	0.363000													8	66					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													4	42					2.7689e-08	3.07266e-08	1	1	0
HCN1	348980	broad.mit.edu	37	5	45262557	45262557	+	Silent	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr5:45262557G>T	ENST00000303230.4	-	8	2196	c.2139C>A	c.(2137-2139)gcC>gcA	p.A713A		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	713						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						AAGTTCGAGCGGCCAGAGGGC	0.657000													3	40					0.00909568	0.00930803	1	1	0
OR2J2	26707	broad.mit.edu	37	6	29141422	29141422	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr6:29141422A>T	ENST00000377167.2	+	1	112	c.10A>T	c.(10-12)Aaa>Taa	p.K4*		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						AATGATGATTAAAAAAAATGC	0.358000													4	87					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12884817	12884817	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:12884817C>T	ENST00000535591.1	-	4	1489	c.1294G>A	c.(1294-1296)Gat>Aat	p.D432N		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	432										NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						CAGTATTGATCTGCCTCCAGG	0.458000													33	119					0	0	1	0	0
CEP152	22995	broad.mit.edu	37	15	49034200	49034200	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr15:49034200C>T	ENST00000380950.2	-	25	4120	c.3933G>A	c.(3931-3933)atG>atA	p.M1311I	CEP152_ENST00000325747.5_Missense_Mutation_p.M1218I|CEP152_ENST00000399334.3_Missense_Mutation_p.M1255I	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	1255					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		AATATTTGCGCATCTTTCGGG	0.438000													6	111					0	0	1	0	0
ZNF606	80095	broad.mit.edu	37	19	58490029	58490029	+	Silent	SNP	A	A	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:58490029A>T	ENST00000341164.4	-	7	2639	c.2019T>A	c.(2017-2019)atT>atA	p.I673I	ZNF606_ENST00000536132.1_Silent_p.I583I	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	673					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		CACCAGTGTGAATTCTCCGAT	0.408000													11	76					0	0	1	0	0
NBPF12	149013	broad.mit.edu	37	1	146398458	146398458	+	Silent	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:146398458G>T	ENST00000442909.2	+	7	1280	c.444G>T	c.(442-444)ctG>ctT	p.L148L	NBPF12_ENST00000446760.2_Silent_p.L148L|NBPF12_ENST00000309471.8_Silent_p.L73L					neuroblastoma breakpoint family, member 12											ovary(2)	2						AAGAACAGCTGGCTGAGGGGT	0.587000													6	137					3.59834e-05	3.847e-05	1	1	0
PLCD4	84812	broad.mit.edu	37	2	219492879	219492879	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:219492879C>T	ENST00000450993.2	+	7	1239	c.900C>T	c.(898-900)ttC>ttT	p.F300F	PLCD4_ENST00000417849.1_Silent_p.F300F|PLCD4_ENST00000432688.1_Silent_p.F300F	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	300	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		ACCACTACTTCATCTGCTCTT	0.532000													11	100					0	0	1	0	0
SP3	6670	broad.mit.edu	37	2	174820352	174820352	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:174820352C>T	ENST00000310015.6	-	4	1418	c.888G>A	c.(886-888)ttG>ttA	p.L296L	SP3_ENST00000455789.2_Silent_p.L243L|SP3_ENST00000418194.2_Silent_p.L228L	NM_001172712.1|NM_003111.4	NP_001166183.1|NP_003102.1	Q02447	SP3_HUMAN	Sp3 transcription factor	296					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	NS(2)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.185)			CTGTGTTTATCAAATGTCCGT	0.398000													8	158					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8465607	8465607	+	Silent	SNP	A	A	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr9:8465607A>G	ENST00000381196.4	-	29	4116	c.3573T>C	c.(3571-3573)taT>taC	p.Y1191Y	PTPRD_ENST00000397606.3_Silent_p.Y770Y|PTPRD_ENST00000358503.5_Silent_p.Y1169Y|PTPRD_ENST00000356435.5_Silent_p.Y1191Y|PTPRD_ENST00000537002.1_Silent_p.Y777Y|PTPRD_ENST00000355233.5_Silent_p.Y780Y|PTPRD_ENST00000397611.3_Silent_p.Y777Y|PTPRD_ENST00000397617.3_Silent_p.Y770Y|PTPRD_ENST00000486161.1_Silent_p.Y780Y|PTPRD_ENST00000360074.4_Silent_p.Y1178Y|PTPRD_ENST00000540109.1_Silent_p.Y1191Y	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1191					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GAGCGGCAATATATGGCTTTA	0.423000										TSP Lung(15;0.13)			6	81					0	0	1	0	0
POU6F1	5463	broad.mit.edu	37	12	51585524	51585524	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr12:51585524C>T	ENST00000389243.4	-	10	1354	c.415G>A	c.(415-417)Gag>Aag	p.E139K	POU6F1_ENST00000550824.1_Missense_Mutation_p.E139K|POU6F1_ENST00000333640.10_Missense_Mutation_p.E139K			Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	139	Gln/Pro-rich.|POU-specific.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	11						ATCCCATCCTCATCCAGACTT	0.542000													6	105					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113679958	113679958	+	Nonsense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:113679958G>C	ENST00000003302.4	-	17	2059	c.1991C>G	c.(1990-1992)tCa>tGa	p.S664*	USP28_ENST00000260188.5_Nonsense_Mutation_p.S664*|USP28_ENST00000545540.1_Nonsense_Mutation_p.S539*|USP28_ENST00000544967.1_Nonsense_Mutation_p.S372*	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	664					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		CATTTGATCTGATTCAGTTGG	0.428000													16	253					0	0	1	0	0
C12orf42	374470	broad.mit.edu	37	12	103795446	103795446	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr12:103795446G>A	ENST00000378113.2	-	3	311	c.86C>T	c.(85-87)cCt>cTt	p.P29L	C12orf42_ENST00000315192.8_Missense_Mutation_p.P29L|C12orf42_ENST00000548883.1_Missense_Mutation_p.P29L|C12orf42_ENST00000548048.1_5'UTR|C12orf42_ENST00000548789.1_5'UTR	NM_001099336.1	NP_001092806.1	Q96LP6	CL042_HUMAN	chromosome 12 open reading frame 42	29										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)	22						AATATAGCAAGGGGATTTCTG	0.428000													5	26					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33959020	33959020	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:33959020C>G	ENST00000361328.3	+	7	1831	c.1678C>G	c.(1678-1680)Cct>Gct	p.P560A		NM_145238.3	NP_660281.2	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	560					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AGGGACATGCCCTTTCTATGA	0.597000													9	100					0	0	1	0	0
SOWAHC	65124	broad.mit.edu	37	2	110373465	110373465	+	Missense_Mutation	SNP	C	C	T	rs147455127		TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:110373465C>T	ENST00000356454.3	+	1	1555	c.1399C>T	c.(1399-1401)Cgt>Tgt	p.R467C		NM_023016.3	NP_075392.2	Q53LP3	ANR57_HUMAN	sosondowah ankyrin repeat domain family member C	467																	CTCTAGTGGACGTATAAAACC	0.597000													5	65					0	0	1	0	0
LRP12	29967	broad.mit.edu	37	8	105503752	105503752	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr8:105503752T>A	ENST00000276654.5	-	7	1837	c.1729A>T	c.(1729-1731)Aat>Tat	p.N577Y	LRP12_ENST00000518375.1_5'UTR|LRP12_ENST00000424843.2_Missense_Mutation_p.N558Y	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	577					endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AGCCTCAGATTTTCCAAAACA	0.348000													8	47					0	0	1	0	0
GEMIN6	79833	broad.mit.edu	37	2	39008728	39008728	+	Silent	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:39008728G>A	ENST00000281950.2	+	3	314	c.198G>A	c.(196-198)caG>caA	p.Q66Q	GEMIN6_ENST00000409566.1_3'UTR|GEMIN6_ENST00000409011.1_3'UTR	NM_024775.9	NP_079051.9	Q8WXD5	GEMI6_HUMAN	gem (nuclear organelle) associated protein 6	66					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	Cajal body|cytosol|spliceosomal complex	protein binding			kidney(1)|large_intestine(3)|pancreas(1)	5		all_hematologic(82;0.21)				ATGCTGTGCAGACTGTTGAAA	0.463000													4	76					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206580937	206580937	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:206580937G>A	ENST00000360409.3	+	3	1063	c.272G>A	c.(271-273)cGg>cAg	p.R91Q	NRP2_ENST00000540841.1_Missense_Mutation_p.R91Q|NRP2_ENST00000417189.1_Missense_Mutation_p.R91Q|NRP2_ENST00000355117.4_Missense_Mutation_p.R91Q|NRP2_ENST00000412873.2_Missense_Mutation_p.R91Q|NRP2_ENST00000357118.4_Missense_Mutation_p.R91Q|NRP2_ENST00000272849.3_Missense_Mutation_p.R91Q|NRP2_ENST00000357785.5_Missense_Mutation_p.R91Q|NRP2_ENST00000540178.1_Missense_Mutation_p.R91Q	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	91	CUB 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						ATCGAGATTCGGGATGGGGAC	0.547000													5	86					0	0	1	0	0
UTP11L	51118	broad.mit.edu	37	1	38484941	38484941	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:38484941C>T	ENST00000373014.4	+	6	514	c.453C>T	c.(451-453)gtC>gtT	p.V151V	UTP11L_ENST00000537711.1_Intron|UTP11L_ENST00000488453.1_3'UTR	NM_016037.3	NP_057121.2	Q9Y3A2	UTP11_HUMAN	UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)	151					induction of apoptosis|nerve growth factor receptor signaling pathway|nervous system development|rRNA processing	cytoplasm|extracellular space|nucleolus|small-subunit processome	protein binding			NS(1)|cervix(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AGTTTGATGTCGCAACTCACC	0.453000													8	103					0	0	1	0	0
IRX4	50805	broad.mit.edu	37	5	1879678	1879678	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr5:1879678C>T	ENST00000505790.1	-	5	1132	c.676G>A	c.(676-678)Gag>Aag	p.E226K	IRX4_ENST00000513692.1_Missense_Mutation_p.E226K|IRX4_ENST00000231357.2_Missense_Mutation_p.E226K|IRX4_ENST00000505938.1_5'UTR	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4	226	Poly-Glu.				heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		ccctcctcctcctcgccctcc	0.687000													3	35					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29295589	29295589	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:29295589C>A	ENST00000331664.5	-	1	1538	c.1539G>T	c.(1537-1539)agG>agT	p.R513S		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	513					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						AAGATTGTGGCCTTGAATGTG	0.542000													12	89					0.000978159	0.00102492	1	1	0
DSP	1832	broad.mit.edu	37	6	7585618	7585618	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr6:7585618C>T	ENST00000379802.3	+	24	8464	c.8123C>T	c.(8122-8124)tCa>tTa	p.S2708L	DSP_ENST00000418664.2_Missense_Mutation_p.S2109L	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2708	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAGAAGATGTCAGCAGCAGAG	0.552000													11	160					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52676401	52676401	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr13:52676401C>G	ENST00000355568.4	-	10	776	c.637G>C	c.(637-639)Gtt>Ctt	p.V213L		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	213	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		ATCTTCAGAACCAGCTGCTGT	0.388000													12	133					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41061990	41061990	+	Splice_Site	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:41061990C>T	ENST00000352632.3	+	25	5171	c.5084_splice	c.e25-1	p.S1695_splice	SPTBN4_ENST00000392023.1_Splice_Site_p.S371_splice|SPTBN4_ENST00000598249.1_Splice_Site_p.S1695_splice|SPTBN4_ENST00000595535.1_Splice_Site_p.S1695_splice|SPTBN4_ENST00000392025.1_Splice_Site_p.S438_splice|SPTBN4_ENST00000338932.3_Splice_Site_p.S1695_splice			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1695					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCCCCTTCAGCGAGCAGATCA	0.657000													5	8					0	0	1	0	0
SP3	6670	broad.mit.edu	37	2	174820724	174820724	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:174820724C>T	ENST00000310015.6	-	4	1046	c.516G>A	c.(514-516)gtG>gtA	p.V172V	SP3_ENST00000455789.2_Silent_p.V119V|SP3_ENST00000418194.2_Silent_p.V104V	NM_001172712.1|NM_003111.4	NP_001166183.1|NP_003102.1	Q02447	SP3_HUMAN	Sp3 transcription factor	172	Transactivation domain (Gln-rich).				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	NS(2)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.185)			TCTGTGGTATCACTTGATATT	0.403000													10	259					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10195049	10195049	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:10195049G>C	ENST00000377157.3	+	15	2355	c.1294G>C	c.(1294-1296)Gat>Cat	p.D432H	UBE4B_ENST00000253251.8_Missense_Mutation_p.D548H|UBE4B_ENST00000343090.6_Missense_Mutation_p.D677H	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	677					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		TTCACAGACAGATGATAGATT	0.378000													3	40					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26553161	26553161	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr12:26553161C>T	ENST00000381340.3	-	53	7846	c.7430G>A	c.(7429-7431)aGg>aAg	p.R2477K	RP11-513G19.1_ENST00000535324.1_RNA	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	2477					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					GTCACACGTCCTTTCAATTCC	0.368000													22	55					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33957252	33957252	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:33957252C>T	ENST00000361328.3	+	6	1547	c.1394C>T	c.(1393-1395)aCc>aTc	p.T465I	ZSCAN20_ENST00000373413.2_Missense_Mutation_p.T411I	NM_145238.3	NP_660281.2	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	465					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GTTGAGTCTACCCAGGGGCCC	0.537000													19	139					0	0	1	0	0
RPTOR	57521	broad.mit.edu	37	17	78681790	78681790	+	Silent	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr17:78681790C>G	ENST00000306801.3	+	4	860	c.498C>G	c.(496-498)gtC>gtG	p.V166V	RPTOR_ENST00000570891.1_Silent_p.V166V|RPTOR_ENST00000544334.2_Silent_p.V166V|RPTOR_ENST00000537330.1_5'UTR	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	166					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						AGGTCTGGGTCTTCAACAAGG	0.602000													4	23					0	0	1	0	0
CASD1	64921	broad.mit.edu	37	7	94167034	94167034	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr7:94167034A>G	ENST00000297273.4	+	9	1381	c.1094A>G	c.(1093-1095)gAa>gGa	p.E365G		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	365						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			TCTTCATTAGAAATACTTTTA	0.338000													4	74					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17202832	17202832	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr16:17202832T>A	ENST00000261381.6	-	12	2684	c.2600A>T	c.(2599-2601)tAc>tTc	p.Y867F		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	867					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CTGCTCCATGTAGGCATTGCG	0.582000													7	57					0	0	1	0	0
HAVCR1	26762	broad.mit.edu	37	5	156479435	156479435	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr5:156479435C>A	ENST00000339252.3	-	3	1142	c.610G>T	c.(610-612)Gtg>Ttg	p.V204L	HAVCR1_ENST00000522693.1_Missense_Mutation_p.V204L|HAVCR1_ENST00000523175.1_Missense_Mutation_p.V204L|HAVCR1_ENST00000544197.1_Missense_Mutation_p.V204L|HAVCR1_ENST00000425854.1_Missense_Mutation_p.V204L	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	199	Thr-rich.				interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTTGTTGTCACTGGAACACTT	0.473000													21	254					1.01871e-10	1.14009e-10	1	1	0
PLCD1	5333	broad.mit.edu	37	3	38053097	38053097	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr3:38053097G>T	ENST00000463876.1	-	4	912	c.559C>A	c.(559-561)Cag>Aag	p.Q187K	PLCD1_ENST00000334661.4_Missense_Mutation_p.Q166K|PLCD1_ENST00000479619.1_5'UTR	NM_001130964.1	NP_001124436.1	P51178	PLCD1_HUMAN	phospholipase C, delta 1	166	EF-hand 2.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		AGGAAGTTCTGCAGCTCCTTG	0.537000													18	18					1.02788e-11	1.16023e-11	1	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146829381	146829381	+	Silent	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr7:146829381C>G	ENST00000361727.3	+	8	1644	c.1128C>G	c.(1126-1128)gtC>gtG	p.V376V		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	376					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.V376V(1)		NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CGGTGCCTGTCTTTTTCAACG	0.458000										HNSCC(39;0.1)			12	65					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186670981	186670981	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:186670981C>G	ENST00000343098.5	+	17	17215	c.17215C>G	c.(17215-17217)Cga>Gga	p.R5739G	FSIP2_ENST00000424728.1_Missense_Mutation_p.R5650G	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						AATAAGAATTCGAACATCAAG	0.383000													5	53					0	0	1	0	0
ZNF544	27300	broad.mit.edu	37	19	58757773	58757773	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:58757773G>A	ENST00000599227.1	+	5	724	c.140G>A	c.(139-141)tGg>tAg	p.W47*	ZNF544_ENST00000596929.1_Nonsense_Mutation_p.W47*|ZNF544_ENST00000415203.2_Nonsense_Mutation_p.W47*|ZNF544_ENST00000596652.1_Nonsense_Mutation_p.W47*|ZNF544_ENST00000595981.1_Nonsense_Mutation_p.W47*|ZNF544_ENST00000600044.1_Nonsense_Mutation_p.W47*|ZNF544_ENST00000333581.5_Nonsense_Mutation_p.W47*|ZNF544_ENST00000269829.4_Nonsense_Mutation_p.W47*|ZNF544_ENST00000599953.1_5'UTR|ZNF544_ENST00000600220.1_Nonsense_Mutation_p.W47*|ZNF544_ENST00000596597.1_3'UTR|ZNF544_ENST00000594384.1_Nonsense_Mutation_p.W47*|ZNF544_ENST00000596825.1_Nonsense_Mutation_p.W47*|CTD-3138B18.4_ENST00000600029.1_Intron			Q6NX49	ZN544_HUMAN	zinc finger protein 544	47	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)|urinary_tract(1)	18		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		CTGGAGACCTGGGAGCATATT	0.552000													19	81					0	0	1	0	0
PAF1	54623	broad.mit.edu	37	19	39880712	39880712	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:39880712T>C	ENST00000221265.3	-	3	497	c.167A>G	c.(166-168)aAc>aGc	p.N56S	PAF1_ENST00000595564.1_Missense_Mutation_p.N46S|PAF1_ENST00000221266.7_Missense_Mutation_p.N46S	NM_019088.3	NP_061961.2	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	56					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|urinary_tract(2)	17	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			GTCTCACCTGTTCTGGTCGAA	0.527000													7	105					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142566032	142566032	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr7:142566032A>G	ENST00000392957.2	+	14	2739	c.1952A>G	c.(1951-1953)tAc>tGc	p.Y651C	EPHB6_ENST00000442129.1_Missense_Mutation_p.Y651C|EPHB6_ENST00000411471.2_Missense_Mutation_p.Y374C	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	651						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					CCCTCCACCTACGAGGACCCC	0.572000													8	63					0	0	1	0	0
HIRIP3	8479	broad.mit.edu	37	16	30005994	30005994	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr16:30005994C>G	ENST00000279392.3	-	4	1302	c.472G>C	c.(472-474)Gag>Cag	p.E158Q	HIRIP3_ENST00000564026.1_Intron	NM_003609.4	NP_003600.2	Q9BW71	HIRP3_HUMAN	HIRA interacting protein 3	158	Glu-rich.				chromatin assembly or disassembly	nucleus	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(9)	17						TCACTGCTCTCCTCTCCCCTC	0.572000													22	262					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36841585	36841585	+	Silent	SNP	A	A	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr20:36841585A>G	ENST00000279024.4	-	14	3733	c.3462T>C	c.(3460-3462)ctT>ctC	p.L1154L		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	1154										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				AGGTGGTGGCAAGCAAATGCT	0.657000													15	44					0	0	1	0	0
MED29	55588	broad.mit.edu	37	19	39883133	39883133	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:39883133G>T	ENST00000315588.5	+	2	358	c.309G>T	c.(307-309)ttG>ttT	p.L103F	MED29_ENST00000599213.2_Missense_Mutation_p.L82F|MED29_ENST00000594368.1_Missense_Mutation_p.L82F	NM_017592.1	NP_060062.1	Q9NX70	MED29_HUMAN	mediator complex subunit 29	82					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	protein binding			lung(2)|ovary(1)|pancreas(1)	4	all_cancers(60;7.82e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;1.04e-26)|all cancers(26;7.68e-24)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CCCAAAACTTGATTCAGAACA	0.423000													17	28					7.45023e-12	8.44573e-12	1	1	0
ACSM2A	123876	broad.mit.edu	37	16	20482884	20482884	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr16:20482884T>C	ENST00000573854.1	+	6	881	c.767T>C	c.(766-768)aTa>aCa	p.I256T	ACSM2A_ENST00000536134.1_Missense_Mutation_p.I28T|ACSM2A_ENST00000396104.2_Missense_Mutation_p.I256T|ACSM2A_ENST00000575690.1_Missense_Mutation_p.I256T|ACSM2A_ENST00000417235.2_Missense_Mutation_p.I177T|ACSM2A_ENST00000219054.6_Missense_Mutation_p.I256T|ACSM2A_ENST00000575558.1_3'UTR	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	256					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GCCTCTGATATAATGTGGACC	0.458000													7	116					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158254065	158254065	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr4:158254065A>T	ENST00000296526.7	+	7	1302	c.977A>T	c.(976-978)aAt>aTt	p.N326I	GRIA2_ENST00000264426.9_Missense_Mutation_p.N326I|GRIA2_ENST00000393815.2_Missense_Mutation_p.N279I|GRIA2_ENST00000449365.1_Missense_Mutation_p.N279I|GRIA2_ENST00000507898.1_Missense_Mutation_p.N279I	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	326					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CGAAGGGGGAATGCAGGAGAC	0.478000													5	49					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52860891	52860891	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr4:52860891C>A	ENST00000343457.3	-	4	2303	c.2297G>T	c.(2296-2298)tGc>tTc	p.C766F		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	766						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						TTGATTCTTGCATTTCCCTGG	0.463000													15	43					2.61681e-11	2.94112e-11	1	1	0
CYB5D2	124936	broad.mit.edu	37	17	4047063	4047063	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr17:4047063G>C	ENST00000301391.3	+	1	514	c.14G>C	c.(13-15)gGa>gCa	p.G5A	CYB5D2_ENST00000575251.1_Intron|CYB5D2_ENST00000573984.1_Intron	NM_144611.3	NP_653212.1	Q8WUJ1	NEUFC_HUMAN	cytochrome b5 domain containing 2	5					nervous system development	extracellular region	heme binding			breast(1)|large_intestine(3)|liver(2)|ovary(1)	7						TTGAGGTGCGGAGGCCGTGGG	0.627000													5	93					0	0	1	0	0
POLA2	23649	broad.mit.edu	37	11	65064728	65064728	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:65064728C>T	ENST00000265465.3	+	18	2316	c.1785C>T	c.(1783-1785)gtC>gtT	p.V595V	POLA2_ENST00000534785.1_3'UTR	NM_002689.2	NP_002680.2	Q14181	DPOA2_HUMAN	polymerase (DNA directed), alpha 2, accessory subunit	595					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding			endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	11					Dacarbazine(DB00851)	CTGTGCAGGTCGTCAGGATCT	0.582000													9	33					0	0	1	0	0
DDX26B	203522	broad.mit.edu	37	X	134679459	134679459	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chrX:134679459C>G	ENST00000370752.4	+	3	635	c.301C>G	c.(301-303)Ctc>Gtc	p.L101V	DDX26B_ENST00000493637.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	101	VWFA.									large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					TTTGTTAAATCTCAATAGATT	0.343000													5	40					0	0	1	0	0
BCAR3	8412	broad.mit.edu	37	1	94054673	94054673	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:94054673C>G	ENST00000370244.1	-	7	1078	c.790G>C	c.(790-792)Gag>Cag	p.E264Q	BCAR3_ENST00000260502.6_Missense_Mutation_p.E264Q|BCAR3_ENST00000370247.3_Missense_Mutation_p.E173Q|BCAR3_ENST00000370243.1_Missense_Mutation_p.E264Q	NM_001261408.1	NP_001248337.1	O75815	BCAR3_HUMAN	breast cancer anti-estrogen resistance 3	264					response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	25		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CCATAATGCTCCTCCAGGCAC	0.672000													3	20					0	0	1	0	0
TAB3	257397	broad.mit.edu	37	X	30872591	30872591	+	Silent	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chrX:30872591G>A	ENST00000378933.1	-	3	1368	c.1191C>T	c.(1189-1191)caC>caT	p.H397H	TAB3_ENST00000288422.2_Silent_p.H397H|TAB3_ENST00000378932.2_Silent_p.H397H|TAB3_ENST00000378930.3_Silent_p.H397H|TAB3-AS2_ENST00000445240.1_RNA	NM_152787.3	NP_690000.2	Q8N5C8	TAB3_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 3	397	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|skin(1)	27						TGTACAGTGAGTGTTGATTCC	0.413000													8	69					0	0	1	0	0
FAM135A	57579	broad.mit.edu	37	6	71235240	71235240	+	Nonsense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr6:71235240C>G	ENST00000418814.2	+	15	3067	c.2453C>G	c.(2452-2454)tCa>tGa	p.S818*	FAM135A_ENST00000505868.1_Nonsense_Mutation_p.S818*|FAM135A_ENST00000505769.1_Intron|FAM135A_ENST00000370479.3_Nonsense_Mutation_p.S605*|FAM135A_ENST00000457062.2_Nonsense_Mutation_p.S605*|FAM135A_ENST00000361499.3_Nonsense_Mutation_p.S622*	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	818										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						GTAAAATTTTCATTAGGAAAT	0.358000													7	48					0	0	1	0	0
GPR148	344561	broad.mit.edu	37	2	131487460	131487460	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:131487460G>T	ENST00000309926.4	+	1	818	c.736G>T	c.(736-738)Gcc>Tcc	p.A246S		NM_207364.2	NP_997247.2	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	246						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(15)|skin(3)|upper_aerodigestive_tract(1)	27	Colorectal(110;0.1)					CTATGCAGAGGCCAAGACTTC	0.557000													5	109					0.014758	0.015044	1	1	0
FAT2	2196	broad.mit.edu	37	5	150946825	150946825	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr5:150946825G>C	ENST00000261800.5	-	1	1680	c.1668C>G	c.(1666-1668)aaC>aaG	p.N556K		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	556	Cadherin 4.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGTCATTCAAGTTCCTGAGCT	0.458000													8	72					0	0	1	0	0
MARCH7	64844	broad.mit.edu	37	2	160604933	160604933	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:160604933G>C	ENST00000259050.3	+	5	1254	c.1132G>C	c.(1132-1134)Gaa>Caa	p.E378Q	MARCH7_ENST00000409591.1_Missense_Mutation_p.E340Q|MARCH7_ENST00000539065.1_Missense_Mutation_p.E322Q|MARCH7_ENST00000409175.1_Missense_Mutation_p.E378Q	NM_022826.2	NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	378	Ser-rich.						ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						CCAAGAATCTGAAGGTAGAAA	0.408000													8	117					0	0	1	0	0
TCTN1	79600	broad.mit.edu	37	12	111085594	111085594	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr12:111085594C>T	ENST00000551590.1	+	14	1817	c.1661C>T	c.(1660-1662)gCg>gTg	p.A554V	TCTN1_ENST00000397659.4_Missense_Mutation_p.A559V|HVCN1_ENST00000548312.1_Intron|TCTN1_ENST00000377654.3_3'UTR|TCTN1_ENST00000397655.3_Missense_Mutation_p.A540V			Q2MV58	TECT1_HUMAN	tectonic family member 1	554					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						ATTTCCACTGCGGTTACTTTT	0.493000													14	30					0	0	1	0	0
TMTC2	160335	broad.mit.edu	37	12	83360728	83360728	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr12:83360728C>T	ENST00000549919.1	+	8	3687	c.1882C>T	c.(1882-1884)Cag>Tag	p.Q628*	TMTC2_ENST00000321196.3_Nonsense_Mutation_p.Q634*			Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat containing 2	634						endoplasmic reticulum|integral to membrane	binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|urinary_tract(1)	39						GGAAGCAATTCAGAAAATGCC	0.343000													4	39					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57924701	57924701	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr15:57924701G>C	ENST00000574161.1	+	7	867	c.748G>C	c.(748-750)Gag>Cag	p.E250Q	GCOM1_ENST00000396180.1_Missense_Mutation_p.E219Q|GCOM1_ENST00000380560.2_Missense_Mutation_p.E181Q|GCOM1_ENST00000380568.3_Missense_Mutation_p.E250Q|GCOM1_ENST00000572390.1_Missense_Mutation_p.E250Q|POLR2M_ENST00000380563.2_5'UTR|MYZAP_ENST00000380565.4_Missense_Mutation_p.E250Q|GCOM1_ENST00000380561.2_Missense_Mutation_p.E219Q|GCOM1_ENST00000380569.2_Missense_Mutation_p.E250Q|MYZAP_ENST00000267853.5_Missense_Mutation_p.E250Q|GCOM1_ENST00000587652.1_Missense_Mutation_p.E250Q	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		250					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						CAGCCAGTATGAGGAGAAGCT	0.493000													6	66					0	0	1	0	0
RPL10L	140801	broad.mit.edu	37	14	47120595	47120595	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr14:47120595C>T	ENST00000298283.3	-	1	433	c.345G>A	c.(343-345)atG>atA	p.M115I		NM_080746.2	NP_542784.1	Q96L21	RL10L_HUMAN	ribosomal protein L10-like	115					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(20)|ovary(1)	27						AGGCACCTCGCATACCTGTCT	0.552000													16	44					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111368447	111368447	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr7:111368447C>T	ENST00000428084.1	-	53	6083	c.5811G>A	c.(5809-5811)ccG>ccA	p.P1937P	DOCK4_ENST00000437633.1_Silent_p.P1928P|DOCK4_ENST00000494651.2_Silent_p.P811P			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1928	Pro-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				GCAGCGCGGGCGGCTCCGACG	0.736000													4	37					0	0	1	0	0
NOX3	50508	broad.mit.edu	37	6	155750022	155750022	+	Missense_Mutation	SNP	C	C	T	rs149980019		TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr6:155750022C>T	ENST00000159060.2	-	9	1153	c.1051G>A	c.(1051-1053)Gtg>Atg	p.V351M		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	351	FAD-binding FR-type.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding	p.V351M(1)		cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CGGATGTGCACGCTGAAAAAG	0.637000													4	65					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196729578	196729578	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:196729578G>C	ENST00000312428.6	-	41	6901	c.6801C>G	c.(6799-6801)agC>agG	p.S2267R		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2267					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AAAACATTAAGCTGCGTAAGT	0.373000													5	113					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129794839	129794839	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:129794839G>C	ENST00000358825.5	-	13	2059	c.1828C>G	c.(1828-1830)Cat>Gat	p.H610D	PRDM10_ENST00000528746.1_Missense_Mutation_p.H580D|PRDM10_ENST00000423662.2_Missense_Mutation_p.H524D|PRDM10_ENST00000360871.3_Missense_Mutation_p.H606D|PRDM10_ENST00000526082.1_Missense_Mutation_p.H524D|PRDM10_ENST00000304538.6_Missense_Mutation_p.H520D	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	610					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TCATTGATATGAATGGCCACA	0.448000													13	110					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33960785	33960785	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:33960785C>T	ENST00000361328.3	+	8	2994	c.2841C>T	c.(2839-2841)atC>atT	p.I947I		NM_145238.3	NP_660281.2	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	947					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CCAAGCTCATCACACACCAGA	0.527000													4	50					0	0	1	0	0
ROR1	4919	broad.mit.edu	37	1	64643788	64643788	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:64643788T>G	ENST00000371079.1	+	9	2439	c.2064T>G	c.(2062-2064)ttT>ttG	p.F688L	ROR1_ENST00000545203.1_Missense_Mutation_p.F139L	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	688	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						TTTTCAGTTTTGGACTCCAGC	0.468000													4	62					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60886035	60886035	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr20:60886035C>G	ENST00000252999.3	-	74	10270	c.10204G>C	c.(10204-10206)Gtt>Ctt	p.V3402L		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	3402	Laminin G-like 4.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATCTGTGCAACGAAGTGGCCA	0.697000													3	36					0	0	1	0	0
SC5D	6309	broad.mit.edu	37	11	121178165	121178165	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:121178165G>C	ENST00000264027.4	+	5	1218	c.844G>C	c.(844-846)Gga>Cga	p.G282R	SC5D_ENST00000534230.1_Splice_Site|SC5D_ENST00000392789.2_Missense_Mutation_p.G282R	NM_006918.4	NP_008849.2			sterol-C5-desaturase																		CAGCCATTCAGGAAATGGCTG	0.403000													5	59					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60802416	60802416	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr17:60802416G>C	ENST00000544856.2	-	8	2362	c.1984C>G	c.(1984-1986)Cag>Gag	p.Q662E	MARCH10_ENST00000311269.5_Missense_Mutation_p.Q663E|MARCH10_ENST00000456609.2_Missense_Mutation_p.Q663E|RP11-156L14.1_ENST00000584597.1_RNA|MARCH10_ENST00000583600.1_Missense_Mutation_p.Q701E|RP11-156L14.1_ENST00000582564.1_RNA|RP11-156L14.1_ENST00000577270.1_RNA|RP11-156L14.1_ENST00000579201.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	663							ligase activity|zinc ion binding	p.Q663E(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						CCGGCTATCTGACAGATGCGA	0.552000													4	64					0	0	1	0	0
TMTC3	160418	broad.mit.edu	37	12	88584324	88584324	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr12:88584324G>A	ENST00000266712.6	+	12	1851	c.1631G>A	c.(1630-1632)cGa>cAa	p.R544Q		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	544						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						AATGAGTCCCGACTGGAAGAA	0.433000													6	50					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34209162	34209162	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:34209162G>C	ENST00000373381.4	-	14	2068	c.1892C>G	c.(1891-1893)tCt>tGt	p.S631C		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	591	CUB 4.					integral to membrane|plasma membrane	protein binding	p.S591Y(1)		NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTAGTTGGGAGACAGGACAAC	0.572000													8	60					0	0	1	0	0
HAUS3	79441	broad.mit.edu	37	4	2240603	2240603	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr4:2240603C>T	ENST00000243706.4	-	3	1306	c.1077G>A	c.(1075-1077)caG>caA	p.Q359Q	POLN_ENST00000515357.1_Intron|POLN_ENST00000511885.2_Intron|HAUS3_ENST00000506763.1_Silent_p.Q359Q|HAUS3_ENST00000443786.2_Silent_p.Q359Q	NM_024511.5	NP_078787.2	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	359					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				breast(3)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GTTTAGCAATCTGCAGATCAA	0.328000													13	87					0	0	1	0	0
CYC1	1537	broad.mit.edu	37	8	145151588	145151588	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr8:145151588C>T	ENST00000318911.4	+	5	786	c.713C>T	c.(712-714)cCt>cTt	p.P238L		NM_001916.3	NP_001907.2	P08574	CY1_HUMAN	cytochrome c-1	238					respiratory electron transport chain|transport	cell junction|integral to membrane|mitochondrial inner membrane|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	15	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;8.71e-40)|all cancers(56;3e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCCTACTTTCCTGGCCAGGCC	0.572000													6	73					0	0	1	0	0
FCHSD2	9873	broad.mit.edu	37	11	72553832	72553832	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:72553832G>C	ENST00000409314.1	-	18	2000	c.1832C>G	c.(1831-1833)tCt>tGt	p.S611C	ATG16L2_ENST00000534905.1_3'UTR|FCHSD2_ENST00000409418.4_Missense_Mutation_p.S587C|FCHSD2_ENST00000311172.7_Missense_Mutation_p.S531C|FCHSD2_ENST00000409263.1_Intron|FCHSD2_ENST00000458644.2_Missense_Mutation_p.S451C			O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	587	SH3 2.						protein binding			endometrium(2)|large_intestine(11)|lung(5)|ovary(2)|prostate(1)|skin(1)	22			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			CTCAGGAAAAGATAACTCATC	0.403000													5	67					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45262532	45262532	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr5:45262532G>C	ENST00000303230.4	-	8	2221	c.2164C>G	c.(2164-2166)Ccc>Gcc	p.P722A		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	722						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity	p.P722S(1)		NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						GAGGCGGTGGGGGAGGCATAG	0.662000													7	37					0	0	1	0	0
GRHL1	29841	broad.mit.edu	37	2	10101374	10101374	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:10101374G>C	ENST00000324907.9	+	4	614	c.478G>C	c.(478-480)Gaa>Caa	p.E160Q	GRHL1_ENST00000324883.5_5'UTR|GRHL1_ENST00000405379.2_Missense_Mutation_p.E160Q	NM_198182.2	NP_937825.2	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1 (Drosophila)	160					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		CATCAAGACAGAAACCCAGCC	0.537000													4	87					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	79971609	79971609	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:79971609G>A	ENST00000466387.1	+	7	923	c.199G>A	c.(199-201)Gcc>Acc	p.A67T	CTNNA2_ENST00000540488.1_Missense_Mutation_p.A67T|CTNNA2_ENST00000402739.4_Missense_Mutation_p.A67T|CTNNA2_ENST00000541047.1_Missense_Mutation_p.A67T|CTNNA2_ENST00000361291.4_Missense_Mutation_p.A101T|CTNNA2_ENST00000496558.1_Missense_Mutation_p.A67T			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	67					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						TGTAGAGCAAGCCACTCAGAA	0.468000													6	35					0	0	1	0	0
ABHD15	116236	broad.mit.edu	37	17	27889898	27889898	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr17:27889898C>G	ENST00000307201.4	-	2	1258	c.1088G>C	c.(1087-1089)tGt>tCt	p.C363S	RP11-68I3.2_ENST00000581474.1_RNA	NM_198147.2	NP_937790.2	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15	363						extracellular region	carboxylesterase activity			breast(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	10						TGGGGGTCCACACACGGGGTC	0.612000													6	70					0	0	1	0	0
FOLR4	390243	broad.mit.edu	37	11	94040666	94040666	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:94040666G>C	ENST00000440961.2	+	4	584	c.540G>C	c.(538-540)gaG>gaC	p.E180D		NM_001199206.1	NP_001186135.1	A6ND01	FOLR4_HUMAN	folate receptor 4, delta (putative)	187						extracellular region	folic acid binding|receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14						ACCTGTGTGAGAAGACTTGGA	0.602000													4	80					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118534050	118534050	+	Silent	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:118534050G>C	ENST00000336338.5	-	37	5528	c.5463C>G	c.(5461-5463)ctC>ctG	p.L1821L		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1821						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TAACCAGCTTGAGGAGATCAG	0.363000													3	30					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	181757	181757	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr5:181757G>T	ENST00000283426.6	+	17	3513	c.3463G>T	c.(3463-3465)Gac>Tac	p.D1155Y		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	1155					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGTGATGAGCGACCGAGTCCC	0.617000													8	83					1.12685e-05	1.22464e-05	1	1	0
FAT1	2195	broad.mit.edu	37	4	187630870	187630870	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr4:187630870C>A	ENST00000441802.2	-	2	321	c.112G>T	c.(112-114)Gag>Tag	p.E38*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	38	Cadherin 1.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						ACGTTGTACTCGAGGTGTGTA	0.493000										HNSCC(5;0.00058)			5	14					1.23904e-05	1.34102e-05	1	1	0
PDE8B	8622	broad.mit.edu	37	5	76649232	76649232	+	Splice_Site	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr5:76649232G>C	ENST00000264917.5	+	10	1212		c.e10+1		PDE8B_ENST00000333194.4_Splice_Site|PDE8B_ENST00000342343.4_Splice_Site|PDE8B_ENST00000340978.3_Splice_Site|PDE8B_ENST00000346042.3_Intron	NM_003719.3	NP_003710.1	O95263	PDE8B_HUMAN	phosphodiesterase 8B						cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		TAATAAGCAGGTATGGTATTA	0.398000													3	35					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	56993873	56993873	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr12:56993873C>G	ENST00000179765.5	-	26	5009	c.4810G>C	c.(4810-4812)Gag>Cag	p.E1604Q	BAZ2A_ENST00000549884.1_Missense_Mutation_p.E1634Q|BAZ2A_ENST00000379441.3_Missense_Mutation_p.E1606Q|BAZ2A_ENST00000551812.1_Missense_Mutation_p.E1636Q			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	1636					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						GGGGTGATCTCATATGATCTG	0.577000													9	97					0	0	1	0	0
LSMEM1	286006	broad.mit.edu	37	7	112124917	112124917	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr7:112124917G>C	ENST00000312849.4	+	2	407	c.46G>C	c.(46-48)Gat>Cat	p.D16H	LSMEM1_ENST00000439068.2_Missense_Mutation_p.D16H|LSMEM1_ENST00000429049.1_Missense_Mutation_p.D16H	NM_182597.2	NP_872403.1			leucine-rich single-pass membrane protein 1																		CATTCAGGAAGATGGAAAGCT	0.453000													8	89					0	0	1	0	0
PARP2	10038	broad.mit.edu	37	14	20824776	20824776	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr14:20824776G>A	ENST00000527915.1	+	13	1301	c.1296G>A	c.(1294-1296)atG>atA	p.M432I	PARP2_ENST00000429687.3_Missense_Mutation_p.M419I|PARP2_ENST00000250416.5_Missense_Mutation_p.M432I			Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase 2	432	PARP catalytic.				protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)	15	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)		GTTCCAGGATGAGTAACTGGG	0.468000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					14	188					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98173032	98173032	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr10:98173032T>A	ENST00000357947.3	-	8	1190	c.965A>T	c.(964-966)aAt>aTt	p.N322I	TLL2_ENST00000469598.1_5'UTR	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	322	Metalloprotease (By similarity).				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CCTGACGCCATTGTCATCTTG	0.522000													10	31					0	0	1	0	0
NOC3L	64318	broad.mit.edu	37	10	96116974	96116974	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr10:96116974G>C	ENST00000371361.3	-	4	565	c.465C>G	c.(463-465)atC>atG	p.I155M	NOC3L_ENST00000463649.1_5'UTR|NOC3L_ENST00000371350.1_Missense_Mutation_p.I155M	NM_022451.9	NP_071896.8	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog (S. cerevisiae)	155						nuclear speck|nucleolus	binding			endometrium(3)|large_intestine(17)|lung(5)|ovary(1)|skin(2)|stomach(1)	29		Colorectal(252;0.0897)				TTTTATCTTTGATAGGAAGTA	0.368000													5	65					0	0	1	0	0
PNPLA8	50640	broad.mit.edu	37	7	108113089	108113089	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr7:108113089G>C	ENST00000426128.2	-	10	2044	c.1919C>G	c.(1918-1920)cCt>cGt	p.P640R	PNPLA8_ENST00000422087.1_Missense_Mutation_p.P702R|PNPLA8_ENST00000453144.1_Missense_Mutation_p.P602R|PNPLA8_ENST00000257694.8_Missense_Mutation_p.P702R|PNPLA8_ENST00000388728.5_Missense_Mutation_p.P640R|PNPLA8_ENST00000436062.1_Missense_Mutation_p.P702R	NM_001256009.1	NP_001242938.1	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	702	Patatin.				fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						GGTGTCAGGAGGTAACAGGCC	0.383000													5	48					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101347136	101347136	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:101347136G>T	ENST00000344327.3	-	6	2064	c.1640C>A	c.(1639-1641)gCa>gAa	p.A547E	TRPC6_ENST00000532133.1_Intron|TRPC6_ENST00000348423.4_Missense_Mutation_p.A431E|TRPC6_ENST00000360497.4_Missense_Mutation_p.A492E	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	547					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		ATGCCAAAATGCCATGAATCT	0.408000													4	71					0.00909568	0.00930803	1	1	0
EML5	161436	broad.mit.edu	37	14	89093259	89093259	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr14:89093259G>C	ENST00000554922.1	-	35	4911	c.4663C>G	c.(4663-4665)Ctt>Gtt	p.L1555V	EML5_ENST00000553320.1_5'UTR|EML5_ENST00000380664.5_Missense_Mutation_p.L1547V|EML5_ENST00000352093.5_Missense_Mutation_p.L1509V	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1547						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						TTGCTAAGAAGAGCTCTTCCT	0.458000													4	76					0	0	1	0	0
RPS15A	6210	broad.mit.edu	37	16	18796121	18796121	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr16:18796121C>T	ENST00000322989.4	-	4	333	c.238G>A	c.(238-240)Gac>Aac	p.D80N	RPS15A_ENST00000565420.1_Missense_Mutation_p.D80N|RPS15A_ENST00000575669.1_5'UTR|RPS15A_ENST00000569083.1_Missense_Mutation_p.D80N|RPS15A_ENST00000563390.1_Missense_Mutation_p.D80N|RPS15A_ENST00000576436.1_Silent_p.*112*	NM_001019.4	NP_001010.2	P62244	RS15A_HUMAN	ribosomal protein S15a	80					endocrine pancreas development|positive regulation of cell cycle|positive regulation of cell proliferation|response to virus|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			endometrium(1)|large_intestine(1)	2						AGTTGCACGTCAAATCTGGGG	0.378000													16	85					0	0	1	0	0
GOLGA2P5	55592	broad.mit.edu	37	12	100551501	100551501	+	RNA	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr12:100551501G>C	ENST00000397112.4	-	0	1697					NR_036632.1															large_intestine(1)|lung(3)	4						AGCTACAGCTGAGTTGAAAAA	0.607000													4	29					0	0	1	0	0
GPSM3	63940	broad.mit.edu	37	6	32160012	32160012	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr6:32160012C>T	ENST00000375040.3	-	2	450	c.58G>A	c.(58-60)Gag>Aag	p.E20K	GPSM3_ENST00000487761.1_Missense_Mutation_p.E17K|GPSM3_ENST00000375043.3_Missense_Mutation_p.E20K	NM_001276501.1	NP_001263430.1	Q9Y4H4	GPSM3_HUMAN	G-protein signaling modulator 3	20	Pro-rich.				signal transduction	cytoplasm	GTPase activator activity|protein binding			large_intestine(1)	1						CAGCCTTCCTCATCCTGAGGG	0.622000													4	30					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129739840	129739840	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:129739840C>G	ENST00000446488.3	-	23	3183	c.3080G>C	c.(3079-3081)aGt>aCt	p.S1027T	NFRKB_ENST00000524746.1_Missense_Mutation_p.S1027T|NFRKB_ENST00000304521.5_Missense_Mutation_p.S1027T|NFRKB_ENST00000524794.1_Missense_Mutation_p.S1052T	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	1027					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		ACTGGCTGAACTGGCCTTGGC	0.542000													6	87					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53025818	53025818	+	Silent	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr8:53025818G>T	ENST00000276480.7	-	26	3767	c.3084C>A	c.(3082-3084)tcC>tcA	p.S1028S		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	1028						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TGCATTCCGGGGAATAGTCCC	0.453000													13	48					7.93312e-07	8.69338e-07	1	1	0
PCDHA5	56143	broad.mit.edu	37	5	140203449	140203449	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr5:140203449G>A	ENST00000529859.1	+	1	2089	c.2089G>A	c.(2089-2091)Gtg>Atg	p.V697M	PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.V697M|PCDHA5_ENST00000529619.1_Missense_Mutation_p.V697M|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATGTCAACGTGTACCTGAT	0.687000													16	67					0	0	1	0	0
PTDSS1	9791	broad.mit.edu	37	8	97311987	97311987	+	Silent	SNP	C	C	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr8:97311987C>A	ENST00000517309.1	+	6	992	c.666C>A	c.(664-666)atC>atA	p.I222I	PTDSS1_ENST00000522072.1_Silent_p.I19I|PTDSS1_ENST00000518776.1_3'UTR|PTDSS1_ENST00000455950.2_Silent_p.I76I	NM_014754.1	NP_055569.1	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	222					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|stomach(1)	29	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	TTCTGGACATCCTGTTGTGCA	0.493000													7	133					0.248553	0.249501	1	1	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													4	33					0	0	1	0	0
FILIP1L	11259	broad.mit.edu	37	3	99568154	99568154	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr3:99568154C>A	ENST00000331335.5	-	5	2836	c.2366G>T	c.(2365-2367)aGa>aTa	p.R789I	FILIP1L_ENST00000354552.3_Missense_Mutation_p.R789I|FILIP1L_ENST00000383694.2_Missense_Mutation_p.R549I|FILIP1L_ENST00000471562.1_Missense_Mutation_p.R549I|CMSS1_ENST00000496116.1_Intron|FILIP1L_ENST00000476723.1_Intron|CMSS1_ENST00000421999.2_Intron|FILIP1L_ENST00000487087.1_Missense_Mutation_p.R365I	NM_001042459.1	NP_001035924.1	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like	789						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						ATCGGAAATTCTTCTTCCATT	0.433000													6	139					3.59834e-05	3.847e-05	1	1	0
PTTG1IP	754	broad.mit.edu	37	21	46281125	46281125	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr21:46281125G>A	ENST00000330938.3	-	3	450	c.230C>T	c.(229-231)cCg>cTg	p.P77L	PTTG1IP_ENST00000445724.2_Intron|PTTG1IP_ENST00000397886.3_Missense_Mutation_p.P56L|PTTG1IP_ENST00000397887.3_Missense_Mutation_p.P77L|PTTG1IP_ENST00000494690.1_5'UTR	NM_004339.3	NP_004330.1	P53801	PTTG_HUMAN	pituitary tumor-transforming 1 interacting protein	77	PSI.				protein import into nucleus	cytoplasm|integral to membrane|nucleus				ovary(1)|prostate(1)	2				Colorectal(79;0.0659)		AAGGGAAGCCGGTGGCAAGAC	0.433000													8	43					0	0	1	0	0
IKBKAP	8518	broad.mit.edu	37	9	111665181	111665181	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr9:111665181C>T	ENST00000374647.5	-	16	2099	c.1792G>A	c.(1792-1794)Gga>Aga	p.G598R	IKBKAP_ENST00000537196.1_Missense_Mutation_p.G249R	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	598					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						ACAGGAAATCCACCAGAGTTC	0.438000													4	48					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98354246	98354246	+	Silent	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:98354246C>G	ENST00000264972.5	+	12	1724	c.1509C>G	c.(1507-1509)ctC>ctG	p.L503L	ZAP70_ENST00000451498.2_Silent_p.L196L|ZAP70_ENST00000463643.1_3'UTR|ZAP70_ENST00000442208.1_Silent_p.L377L	NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	503	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						AGTGGCCGCTCAAGTGGTACG	0.637000													6	123					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173931010	173931010	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:173931010C>G	ENST00000367696.2	-	12	2406	c.2055G>C	c.(2053-2055)gaG>gaC	p.E685D	RC3H1_ENST00000367694.2_Missense_Mutation_p.E685D|RC3H1_ENST00000258349.4_Missense_Mutation_p.E685D			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	685	Pro-rich.				cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						CTCGGAATATCTCTTCTCTTG	0.478000													10	178					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122033559	122033559	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr7:122033559T>G	ENST00000334010.7	-	19	3239	c.2818A>C	c.(2818-2820)Atg>Ctg	p.M940L	CADPS2_ENST00000313070.7_Missense_Mutation_p.M936L|CADPS2_ENST00000412584.2_Missense_Mutation_p.M936L|CADPS2_ENST00000449022.2_Missense_Mutation_p.M942L|RP5-1101C3.1_ENST00000593910.1_RNA|RP5-1101C3.1_ENST00000591140.1_RNA	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	942	Interaction with DRD2.|MHD1.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						GAAGACTCCATGAGATCCACA	0.458000													25	64					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49957773	49957773	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chrX:49957773C>A	ENST00000376056.2	-	5	1714	c.1564G>T	c.(1564-1566)Gaa>Taa	p.E522*	AKAP4_ENST00000376064.3_Nonsense_Mutation_p.E522*|AKAP4_ENST00000358526.2_Nonsense_Mutation_p.E531*|AKAP4_ENST00000376058.2_Intron|AKAP4_ENST00000481402.1_5'UTR			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	531					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					TTGATCTTTTCTCCTTTCTCA	0.463000													7	58					8.12818e-05	8.58519e-05	1	1	0
OR5AK2	390181	broad.mit.edu	37	11	56756711	56756711	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:56756711C>G	ENST00000326855.2	+	1	365	c.323C>G	c.(322-324)gCa>gGa	p.A108G		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						GCAACATTTGCAACCAGTGAC	0.423000													11	74					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108604727	108604727	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:108604727G>A	ENST00000264047.2	+	2	392	c.116G>A	c.(115-117)aGc>aAc	p.S39N	SLC5A7_ENST00000540517.1_Intron|SLC5A7_ENST00000409059.1_Missense_Mutation_p.S39N	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	39					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	GAAGAGCGCAGCGAAGCCATC	0.507000													4	72					0	0	1	0	0
REXO1	57455	broad.mit.edu	37	19	1827499	1827499	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:1827499G>A	ENST00000170168.4	-	2	1383	c.1289C>T	c.(1288-1290)cCg>cTg	p.P430L		NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	430						nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTCCCTTCCGGCCGCTCTGC	0.706000													6	29					0	0	1	0	0
TAZ	6901	broad.mit.edu	37	X	153648522	153648522	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chrX:153648522C>T	ENST00000369776.4	+	5	613	c.528C>T	c.(526-528)caC>caT	p.H176H	TAZ_ENST00000351413.4_Intron|TAZ_ENST00000369790.4_Intron|TAZ_ENST00000299328.5_Intron|TAZ_ENST00000350743.4_Intron|TAZ_ENST00000498029.1_Intron			Q16635	TAZ_HUMAN	tafazzin	215	Hydrophilic.				cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity			lung(1)	1	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTCCACCCCACGTCTGGCCTT	0.642000													10	92					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037532	75037532	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:75037532C>T	ENST00000326665.5	-	14	4080	c.3862G>A	c.(3862-3864)Gaa>Aaa	p.E1288K	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1288	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCCACCGCTTCCTCCCTGAAC	0.567000													5	126					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1651988	1651988	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:1651988C>T	ENST00000252804.4	-	17	3614	c.3564G>A	c.(3562-3564)ctG>ctA	p.L1188L		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1188					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TCTCATTTTTCAGGTCCTCGA	0.562000													7	143					0	0	1	0	0
FBXL20	84961	broad.mit.edu	37	17	37499496	37499496	+	Splice_Site	SNP	T	T	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr17:37499496T>C	ENST00000264658.6	-	2	303		c.e2-2		FBXL20_ENST00000577399.1_Splice_Site|FBXL20_ENST00000394294.3_Splice_Site|FBXL20_ENST00000583610.1_Splice_Site	NM_032875.2	NP_116264.2	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20							cytoplasm				breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22			LUAD - Lung adenocarcinoma(14;0.146)			TGAGAACATCTGCAAAAACAA	0.308000													6	26					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111408321	111408321	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:111408321G>C	ENST00000535254.1	-	17	2012	c.1945C>G	c.(1945-1947)Cac>Gac	p.H649D	BUB1_ENST00000302759.6_Missense_Mutation_p.H669D|BUB1_ENST00000409311.1_Missense_Mutation_p.H669D	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	669					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		GAATACATGTGAGACGACAAG	0.473000													5	38					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33960364	33960364	+	Nonsense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:33960364C>G	ENST00000361328.3	+	8	2573	c.2420C>G	c.(2419-2421)tCa>tGa	p.S807*		NM_145238.3	NP_660281.2	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	807					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AACCAGAGCTCAAACCTTCTG	0.458000													13	140					0	0	1	0	0
BTN2A1	11120	broad.mit.edu	37	6	26468373	26468373	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr6:26468373A>G	ENST00000312541.5	+	8	1428	c.1180A>G	c.(1180-1182)Aac>Gac	p.N394D	BTN2A1_ENST00000429381.1_3'UTR|BTN2A1_ENST00000541522.1_Missense_Mutation_p.N333D|BTN2A1_ENST00000469185.1_Intron	NM_007049.3|NM_078476.2	NP_008980.1|NP_510961.1	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1	394	B30.2/SPRY.				lipid metabolic process	integral to plasma membrane				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(3)	27						GGAGGTGGAAAACGTGATTGA	0.547000													6	97					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1677575	1677575	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:1677575C>T	ENST00000252804.4	-	9	908	c.858G>A	c.(856-858)ctG>ctA	p.L286L	PXDN_ENST00000483018.1_5'UTR	NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	286	Ig-like C2-type 1.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TCTTCATGCTCAGCTCATTAC	0.512000													4	64					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282185	152282185	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:152282185G>T	ENST00000368799.1	-	3	5212	c.5177C>A	c.(5176-5178)tCa>tAa	p.S1726*	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1726	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACTCTTCTGAGTGTCCCTC	0.592000									Ichthyosis				76	224					5.96624e-29	6.79274e-29	1	1	0
CUL4A	8451	broad.mit.edu	37	13	113893751	113893751	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr13:113893751C>T	ENST00000451881.1	+	10	870	c.621C>T	c.(619-621)ctC>ctT	p.L207L	CUL4A_ENST00000375440.4_Silent_p.L307L|CUL4A_ENST00000326335.4_Silent_p.L207L|CUL4A_ENST00000375441.3_Silent_p.L207L	NM_001278513.1|NM_003589.2	NP_001265442.1|NP_003580.1	Q13619	CUL4A_HUMAN	cullin 4A	307					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|skin(1)	17	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			TCTCAGGGCTCGACCACTTAC	0.557000													5	63					0	0	1	0	0
CCDC173	129881	broad.mit.edu	37	2	170505760	170505760	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:170505760C>T	ENST00000447353.1	-	8	1354	c.1249G>A	c.(1249-1251)Gaa>Aaa	p.E417K		NM_001085447.1	NP_001078916.1			coiled-coil domain containing 173									p.E411K(1)									TTCTCCTTTTCATGTTCCCAG	0.333000													10	41					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140281940	140281940	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr3:140281940G>C	ENST00000458420.3	+	15	2567	c.2377G>C	c.(2377-2379)Gac>Cac	p.D793H		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	793					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						CCTTCATGAAGACCAAGTCTC	0.522000										HNSCC(16;0.037)			13	108					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193201786	193201786	+	Silent	SNP	T	T	A	rs149388699		TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr3:193201786T>A	ENST00000342695.4	-	8	1069	c.747A>T	c.(745-747)gtA>gtT	p.V249V	ATP13A4_ENST00000295548.3_Silent_p.V249V|ATP13A4_ENST00000392443.3_Silent_p.V249V	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	249					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GGTGGAGTTTTACAGATTGCT	0.353000													5	129					0	0	1	0	0
ZNF23	7571	broad.mit.edu	37	16	71483713	71483713	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr16:71483713C>G	ENST00000393539.2	-	6	1028	c.215G>C	c.(214-216)aGa>aCa	p.R72T	ZNF23_ENST00000539742.1_5'UTR|ZNF23_ENST00000357254.4_Missense_Mutation_p.R72T|ZNF23_ENST00000358700.2_3'UTR|ZNF23_ENST00000417828.1_Missense_Mutation_p.R72T|ZNF23_ENST00000497160.1_3'UTR|RP11-510M2.10_ENST00000576258.1_RNA|ZNF23_ENST00000428724.2_Missense_Mutation_p.R14T|AC010547.9_ENST00000561908.1_3'UTR|ZNF23_ENST00000564528.1_Missense_Mutation_p.R14T	NM_145911.1	NP_666016.1	P17027	ZNF23_HUMAN	zinc finger protein 23	72					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(14)|stomach(1)|urinary_tract(1)	29		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		GGAAAAGTCTCTTTGAAGTTC	0.348000													10	73					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33960848	33960848	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:33960848C>T	ENST00000361328.3	+	8	3057	c.2904C>T	c.(2902-2904)ttC>ttT	p.F968F		NM_145238.3	NP_660281.2	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	968					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GAAAATTCTTCCGTGACCGTT	0.498000													4	39					0	0	1	0	0
CYP1B1	1545	broad.mit.edu	37	2	38297968	38297968	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:38297968G>A	ENST00000260630.3	-	3	1930	c.1529C>T	c.(1528-1530)aCc>aTc	p.T510I	CYP1B1_ENST00000407341.1_Missense_Mutation_p.T510I|CYP1B1_ENST00000494864.1_5'UTR	NM_000104.3	NP_000095.2	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B, polypeptide 1	510					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	13		all_hematologic(82;0.21)			Estrone(DB00655)	GGGTTTAATGGTTAGACCATA	0.433000													13	79					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578268	7578268	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr17:7578268A>C	ENST00000420246.2	-	6	713	c.581T>G	c.(580-582)cTt>cGt	p.L194R	TP53_ENST00000359597.4_Missense_Mutation_p.L194R|TP53_ENST00000455263.2_Missense_Mutation_p.L194R|TP53_ENST00000269305.4_Missense_Mutation_p.L194R|TP53_ENST00000413465.2_Missense_Mutation_p.L194R|TP53_ENST00000445888.2_Missense_Mutation_p.L194R|TP53_ENST00000574684.1_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	194	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		L -> F (in sporadic cancers; somatic mutation).|L -> H (in sporadic cancers; somatic mutation).|L -> I (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L194R(47)|p.L194P(8)|p.L194H(8)|p.0?(8)|p.?(6)|p.L101R(5)|p.L62R(5)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.P191fs*53(2)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.P59_E66>Q(1)|p.L194fs*15(1)|p.L194fs*14(1)|p.L101H(1)|p.L194fs*52(1)|p.P98_E105>Q(1)|p.A189fs*53(1)|p.L62H(1)|p.I195fs*52(1)|p.H193_I195>AP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACTCGGATAAGATGCTGAGG	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	17					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85742694	85742694	+	Silent	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr4:85742694C>G	ENST00000322366.6	-	11	1541	c.1134G>C	c.(1132-1134)gtG>gtC	p.V378V	WDFY3_ENST00000295888.4_Silent_p.V378V			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	378						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GGACGTTTCTCACACTGTGAC	0.338000													5	71					0	0	1	0	0
ADGRG6	57211	broad.mit.edu	37	6	142741141	142741141	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr6:142741141G>C	ENST00000230173.6	+	22	3695	c.3219G>C	c.(3217-3219)ttG>ttC	p.L1073F	GPR126_ENST00000367609.3_Missense_Mutation_p.L1073F|GPR126_ENST00000367608.2_Missense_Mutation_p.L1045F|GPR126_ENST00000296932.8_Missense_Mutation_p.L1045F	NM_020455.5	NP_065188.4	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	1073					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		TGGTTAGCTTGACCTTTCTGT	0.473000													8	126					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123725945	123725945	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr9:123725945C>T	ENST00000223642.1	-	34	4321	c.4292G>A	c.(4291-4293)gGa>gAa	p.G1431E		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1431					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TGCACTGATTCCAGTAGGCAA	0.353000													11	38					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170031721	170031721	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:170031721C>T	ENST00000263816.3	-	55	11035	c.10750G>A	c.(10750-10752)Gaa>Aaa	p.E3584K		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3584	LDL-receptor class A 27.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGACGGTCTTCATCAGACCCA	0.483000													4	55					0	0	1	0	0
OR1A2	26189	broad.mit.edu	37	17	3101498	3101498	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr17:3101498C>T	ENST00000381951.1	+	1	686	c.686C>T	c.(685-687)tCt>tTt	p.S229F		NM_012352.1	NP_036484.1	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A, member 2	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(4)|stomach(2)	18						CAAGTTCCATCTACCAAGAGT	0.448000													9	151					0	0	1	0	0
SQRDL	58472	broad.mit.edu	37	15	45974742	45974742	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr15:45974742G>C	ENST00000260324.7	+	7	1317	c.931G>C	c.(931-933)Gat>Cat	p.D311H	SQRDL_ENST00000568606.1_Missense_Mutation_p.D311H	NM_021199.2	NP_067022.1	Q9Y6N5	SQRD_HUMAN	sulfide quinone reductase-like (yeast)	311							oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	11		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		TCCTGTGGCTGATGCTGCTGG	0.468000													6	49					0	0	1	0	0
SUZ12P1	440423	broad.mit.edu	37	17	29061941	29061941	+	RNA	SNP	T	T	C	rs112064181	by1000genomes	TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr17:29061941T>C	ENST00000582557.1	+	0	861																											TAGATTTCTTTGAACTCGGAA	0.303000													5	59					0	0	1	0	0
PAPSS2	9060	broad.mit.edu	37	10	89501080	89501080	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr10:89501080G>A	ENST00000361175.4	+	9	1529	c.1160G>A	c.(1159-1161)cGt>cAt	p.R387H	PAPSS2_ENST00000427144.2_Missense_Mutation_p.R391H|PAPSS2_ENST00000456849.1_Missense_Mutation_p.R392H	NM_004670.3	NP_004661.2	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	387					3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	20		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		GACCAATACCGTCTGACACCT	0.413000													4	60					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106509542	106509542	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr7:106509542C>G	ENST00000359195.3	+	2	1846	c.1536C>G	c.(1534-1536)aaC>aaG	p.N512K	PIK3CG_ENST00000496166.1_Missense_Mutation_p.N512K|PIK3CG_ENST00000440650.2_Missense_Mutation_p.N512K	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	512					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						ACAAGGAGAACTCAATGTCCA	0.532000													4	90					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66945151	66945151	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr16:66945151C>T	ENST00000299752.4	-	14	2051	c.1858G>A	c.(1858-1860)Gcc>Acc	p.A620T	CDH16_ENST00000394055.3_Missense_Mutation_p.A620T|CDH16_ENST00000568632.1_Missense_Mutation_p.A523T|CDH16_ENST00000565796.1_Missense_Mutation_p.A620T|CDH16_ENST00000570262.1_Missense_Mutation_p.A540T	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	620	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		AGGGACTGGGCGGTGTGCACC	0.627000													3	25					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73904786	73904786	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr6:73904786G>T	ENST00000342056.2	+	15	2903	c.2505G>T	c.(2503-2505)ttG>ttT	p.L835F	KCNQ5_ENST00000370398.1_Missense_Mutation_p.L816F|KCNQ5_ENST00000355635.3_Missense_Mutation_p.L817F|KCNQ5_ENST00000402622.2_Missense_Mutation_p.L826F|KCNQ5_ENST00000355194.4_Missense_Mutation_p.L816F|KCNQ5_ENST00000414165.2_Missense_Mutation_p.L706F|KCNQ5_ENST00000403813.2_Missense_Mutation_p.L807F	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	816					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		AAACTCTGTTGTCTGTCTGTC	0.478000													5	72					0.184627	0.186042	1	1	0
PPAPDC3	84814	broad.mit.edu	37	9	134165696	134165696	+	Silent	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr9:134165696G>A	ENST00000372264.3	+	1	616	c.312G>A	c.(310-312)gcG>gcA	p.A104A	PPAPDC3_ENST00000372261.1_Silent_p.A104A	NM_032728.3	NP_116117.3	Q8NBV4	PPAC3_HUMAN	phosphatidic acid phosphatase type 2 domain containing 3	104						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)		GCCGGGCGGCGTCCTGGGCCA	0.647000													12	65					0	0	1	0	0
LCLAT1	253558	broad.mit.edu	37	2	30863480	30863480	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:30863480G>C	ENST00000309052.4	+	7	1449	c.1240G>C	c.(1240-1242)Gag>Cag	p.E414Q	LCLAT1_ENST00000379509.3_Missense_Mutation_p.E376Q|LCLAT1_ENST00000540623.1_Missense_Mutation_p.E376Q|LCLAT1_ENST00000491680.2_3'UTR	NM_182551.3	NP_872357.2	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1	414					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)	19						AAAGAAAAATGAGTAAGATTA	0.353000													4	53					0	0	1	0	0
FAR2P3	100288897	broad.mit.edu	37	2	131459980	131459980	+	RNA	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:131459980G>A	ENST00000425151.1	+	0	507																											TTCTATCTGTGGCTCATTGGA	0.498000													3	2					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													4	37					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111695502	111695502	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr6:111695502C>T	ENST00000435970.1	-	15	4638	c.3822G>A	c.(3820-3822)acG>acA	p.T1274T	REV3L_ENST00000368802.3_Silent_p.T1352T|REV3L_ENST00000368805.1_Silent_p.T1352T|REV3L_ENST00000358835.3_Silent_p.T1352T			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1352					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TTTGAATTAACGTTGATTCCT	0.323000								DNA polymerases (catalytic subunits)					14	74					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33879620	33879620	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr20:33879620C>T	ENST00000374408.3	-	1	584	c.488G>A	c.(487-489)cGc>cAc	p.R163H		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	163										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GAAAAGGAAGCGCAGCAGGTC	0.612000													16	93					0	0	1	0	0
FAM111A	63901	broad.mit.edu	37	11	58920123	58920123	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:58920123G>C	ENST00000528737.1	+	5	3800	c.982G>C	c.(982-984)Gaa>Caa	p.E328Q	FAM111A_ENST00000420244.1_Missense_Mutation_p.E328Q|FAM111A_ENST00000533703.1_Missense_Mutation_p.E328Q|FAM111A_ENST00000531147.1_Missense_Mutation_p.E328Q|FAM111A_ENST00000361723.3_Missense_Mutation_p.E328Q			Q96PZ2	F111A_HUMAN	family with sequence similarity 111, member A	328					proteolysis		serine-type endopeptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_epithelial(135;0.139)				AACATTATTTGAATTGCATAG	0.323000													7	56					0	0	1	0	0
IFNL3	282617	broad.mit.edu	37	19	39734514	39734514	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:39734514G>A	ENST00000413851.2	-	4	480	c.442C>T	c.(442-444)Cgg>Tgg	p.R148W		NM_172139.2	NP_742151.2			interferon, lambda 3																		AGGCGGCCCCGGGTCCTGGGC	0.692000													6	70					0	0	1	0	0
LIN7B	64130	broad.mit.edu	37	19	49619650	49619650	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:49619650C>T	ENST00000221459.2	+	4	403	c.359C>T	c.(358-360)tCc>tTc	p.S120F	LIN7B_ENST00000391864.3_Intron	NM_022165.2	NP_071448.1	Q9HAP6	LIN7B_HUMAN	lin-7 homolog B (C. elegans)	120	PDZ.				exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein domain specific binding			central_nervous_system(1)|endometrium(1)|prostate(1)	3		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;5e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000191)|GBM - Glioblastoma multiforme(486;0.00449)|Epithelial(262;0.01)		ATCTACATCTCCCGGGTCATC	0.607000													22	26					0	0	1	0	0
BMPR2	659	broad.mit.edu	37	2	203383547	203383547	+	Silent	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:203383547G>C	ENST00000374580.4	+	6	1163	c.624G>C	c.(622-624)ctG>ctC	p.L208L	BMPR2_ENST00000374574.2_Silent_p.L208L	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	208	Protein kinase.				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						ACTTGCAGCTGATTGGCCGAG	0.353000													5	53					0	0	1	0	0
APBB1	322	broad.mit.edu	37	11	6422225	6422225	+	Missense_Mutation	SNP	G	G	A	rs147235391		TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:6422225G>A	ENST00000389906.2	-	11	1765	c.1666C>T	c.(1666-1668)Cct>Tct	p.P556S	APBB1_ENST00000299402.6_Missense_Mutation_p.P554S|APBB1_ENST00000524626.1_5'UTR|APBB1_ENST00000311051.3_Missense_Mutation_p.P554S|APBB1_ENST00000530885.1_Missense_Mutation_p.P334S	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	556	PID 2.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		ATACCAACAGGTTTAGCAACA	0.478000													15	192					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	187004655	187004655	+	Silent	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr4:187004655C>G	ENST00000296795.2	+	4	1919	c.1815C>G	c.(1813-1815)gtC>gtG	p.V605V	TLR3_ENST00000504367.1_Silent_p.V328V	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	605					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		CAGCATCTGTCTTTAATAATC	0.393000													4	66					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248684949	248684949	+	Translation_Start_Site	SNP	T	T	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:248684949T>C	ENST00000343414.4	+	1	34	c.2T>C	c.(1-3)aTg>aCg	p.M1T		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCAGGAAAAATGGAGGAAACC	0.398000													10	106					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116616662	116616662	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr8:116616662C>G	ENST00000395715.3	-	4	2111	c.1534G>C	c.(1534-1536)Gac>Cac	p.D512H	TRPS1_ENST00000520276.1_Missense_Mutation_p.D503H|TRPS1_ENST00000220888.5_Missense_Mutation_p.D499H|TRPS1_ENST00000519674.1_Missense_Mutation_p.D499H|TRPS1_ENST00000519076.1_Intron	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	499					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GAGCTCTTGTCTGTCTTGGTC	0.443000									Langer-Giedion syndrome				7	108					0	0	1	0	0
MLKL	197259	broad.mit.edu	37	16	74729256	74729256	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr16:74729256C>T	ENST00000308807.7	-	2	863	c.400G>A	c.(400-402)Gca>Aca	p.A134T	MLKL_ENST00000306247.7_Missense_Mutation_p.A134T	NM_152649.2	NP_689862.1	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like	134							ATP binding|protein binding|protein kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(6)|skin(1)|stomach(2)	19						TCTTCCTGTGCCCAGGACGCT	0.542000													8	92					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248343476	248343476	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:248343476C>T	ENST00000359682.2	+	1	189	c.189C>T	c.(187-189)ctC>ctT	p.L63L		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACTTCCTCCTCAGCCAACTGT	0.532000													13	348					0	0	1	0	0
UACA	55075	broad.mit.edu	37	15	70961172	70961172	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr15:70961172T>A	ENST00000322954.6	-	16	2036	c.1851A>T	c.(1849-1851)aaA>aaT	p.K617N	UACA_ENST00000560441.1_Missense_Mutation_p.K602N|UACA_ENST00000379983.2_Missense_Mutation_p.K604N|UACA_ENST00000539319.1_Missense_Mutation_p.K508N	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	617						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						CTGACAATTCTTTTGCCTGGC	0.378000													5	70					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158735613	158735613	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:158735613G>C	ENST00000335094.2	-	1	879	c.860C>G	c.(859-861)cCc>cGc	p.P287R		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					GTAGATGAAGGGGTTGAGGAA	0.522000													11	129					0	0	1	0	0
SLC4A9	83697	broad.mit.edu	37	5	139743448	139743448	+	Silent	SNP	T	T	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr5:139743448T>C	ENST00000230993.6	+	9	1322	c.1287T>C	c.(1285-1287)acT>acC	p.T429T	SLC4A9_ENST00000507527.1_Silent_p.T429T|SLC4A9_ENST00000506757.2_Silent_p.T405T|SLC4A9_ENST00000506545.1_Silent_p.T405T|SLC4A9_ENST00000432095.2_Silent_p.T394T	NM_001258428.1	NP_001245357.1	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 9	429	Membrane (anion exchange).					integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCCATCACTTTTGGGGGTC	0.602000													4	36					0	0	1	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88932144	88932144	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr9:88932144T>A	ENST00000277141.6	-	18	3555	c.1131A>T	c.(1129-1131)agA>agT	p.R377S	ZCCHC6_ENST00000375961.2_Missense_Mutation_p.R1088S|ZCCHC6_ENST00000375960.2_Missense_Mutation_p.R852S|ZCCHC6_ENST00000375957.1_Missense_Mutation_p.R26S|ZCCHC6_ENST00000375963.3_Missense_Mutation_p.R1088S			Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	1088					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						CTGAATGTTTTCTGAGGACTC	0.353000													8	62					0	0	1	0	0
ADPRH	141	broad.mit.edu	37	3	119305355	119305355	+	Silent	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr3:119305355G>A	ENST00000478399.1	+	3	1927	c.522G>A	c.(520-522)gcG>gcA	p.A174A	ADPRH_ENST00000471850.1_3'UTR|ADPRH_ENST00000465513.1_Silent_p.A174A|ADPRH_ENST00000357003.3_Silent_p.A174A|ADPRH_ENST00000478927.1_Silent_p.A174A			P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	174					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			breast(1)|kidney(1)|lung(10)|ovary(1)	13		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		GGGCCCTTGCGTCTGCTCTTT	0.537000													9	218					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33960221	33960221	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:33960221C>G	ENST00000361328.3	+	8	2430	c.2277C>G	c.(2275-2277)atC>atG	p.I759M		NM_145238.3	NP_660281.2	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	759					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				ATCAGAGAATCCACACTGGAG	0.453000													9	94					0	0	1	0	0
CCNT2	905	broad.mit.edu	37	2	135694482	135694482	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:135694482C>G	ENST00000264157.5	+	3	342	c.312C>G	c.(310-312)atC>atG	p.I104M	CCNT2_ENST00000537343.1_5'UTR|CCNT2_ENST00000295238.6_Missense_Mutation_p.I104M	NM_001241.3|NM_058241.2	NP_001232.1|NP_490595.1	O60583	CCNT2_HUMAN	cyclin T2	104					cell cycle|cell division|interspecies interaction between organisms|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein kinase binding			endometrium(2)|kidney(3)|large_intestine(10)|lung(6)|ovary(2)|prostate(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.107)		AACATGTTATCAAAGTAGCAC	0.343000													6	55					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54783471	54783471	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:54783471C>A	ENST00000391748.1	-	5	514	c.387G>T	c.(385-387)caG>caT	p.Q129H	LILRB2_ENST00000391749.4_Missense_Mutation_p.Q129H|LILRB2_ENST00000391746.1_Missense_Mutation_p.Q129H|LILRB2_ENST00000434421.1_Missense_Mutation_p.Q13H|LILRB2_ENST00000314446.5_Missense_Mutation_p.Q129H	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	129	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAGGGCTGGGCTGGGCTGAGA	0.587000													25	91					4.59853e-10	5.12463e-10	1	1	0
PPP2R2C	5522	broad.mit.edu	37	4	6335418	6335418	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr4:6335418G>C	ENST00000335585.5	-	7	854	c.831C>G	c.(829-831)ttC>ttG	p.F277L	PPP2R2C_ENST00000382599.4_Missense_Mutation_p.F277L|PPP2R2C_ENST00000515571.1_Missense_Mutation_p.F260L|PPP2R2C_ENST00000506140.1_Missense_Mutation_p.F270L|PPP2R2C_ENST00000507294.1_Missense_Mutation_p.F270L	NM_181876.2	NP_870991.1	Q9Y2T4	2ABG_HUMAN	protein phosphatase 2, regulatory subunit B, gamma	277					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	28						TGATTTCCGAGAAGAATGAGC	0.582000											OREG0016071	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	57					0	0	1	0	0
LRRTM4	80059	broad.mit.edu	37	2	77746430	77746430	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:77746430C>T	ENST00000409088.3	-	3	979	c.565G>A	c.(565-567)Ggt>Agt	p.G189S	LRRTM4_ENST00000409282.1_Missense_Mutation_p.G190S|LRRTM4_ENST00000409911.1_Missense_Mutation_p.G190S|LRRTM4_ENST00000409884.1_Missense_Mutation_p.G189S|LRRTM4_ENST00000409093.1_Missense_Mutation_p.G189S	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	189						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		CGATTGTAACCCAAATCCAAA	0.423000													25	33					0	0	1	0	0
WISP1	8840	broad.mit.edu	37	8	134239811	134239811	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr8:134239811C>T	ENST00000250160.6	+	5	1068	c.962C>T	c.(961-963)tCc>tTc	p.S321F	WISP1_ENST00000519433.1_Missense_Mutation_p.S76F|WISP1_ENST00000220856.6_Missense_Mutation_p.S234F|WISP1_ENST00000517423.1_3'UTR|WISP1_ENST00000377863.2_Missense_Mutation_p.S149F	NM_003882.3	NP_003873.1	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	321	CTCK.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			ATCGACGTGTCCTTCCAGTGT	0.517000													5	79					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62652608	62652608	+	Missense_Mutation	SNP	C	C	A	rs141139124	by1000genomes	TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr10:62652608C>A	ENST00000337910.5	-	5	779	c.442G>T	c.(442-444)Gac>Tac	p.D148Y	RHOBTB1_ENST00000357917.4_Missense_Mutation_p.D148Y	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	148	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding	p.D148Y(1)		endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					GCTTCCAGGTCGGCATAGCGG	0.502000													4	52					0.150653	0.15298	1	1	0
OR14C36	127066	broad.mit.edu	37	1	248512914	248512914	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:248512914C>T	ENST00000317861.1	+	1	838	c.838C>T	c.(838-840)Cct>Tct	p.P280S		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						TTCCATAATGCCTCCCCTCTT	0.403000													23	86					0	0	1	0	0
SLC6A14	11254	broad.mit.edu	37	X	115582732	115582732	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chrX:115582732G>C	ENST00000371900.4	+	8	1144	c.1056G>C	c.(1054-1056)ttG>ttC	p.L352F		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	352					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	TGGTTTGTTTGACAAACTGTC	0.383000													6	53					0	0	1	0	0
ZNF682	91120	broad.mit.edu	37	19	20117026	20117026	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:20117026C>T	ENST00000397165.2	-	4	1445	c.1285G>A	c.(1285-1287)Gaa>Aaa	p.E429K	ZNF682_ENST00000595736.1_Missense_Mutation_p.E353K|ZNF682_ENST00000597972.1_Missense_Mutation_p.E435K|ZNF682_ENST00000397162.1_Missense_Mutation_p.E397K|ZNF682_ENST00000358523.5_Missense_Mutation_p.E397K|ZNF682_ENST00000596019.1_Intron	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	429					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						TTTCCACATTCTTCACAGTTG	0.388000													3	46					0	0	1	0	0
CLEC17A	388512	broad.mit.edu	37	19	14710995	14710995	+	Splice_Site	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:14710995G>T	ENST00000547437.1	+	12	971		c.e12+1		CLEC17A_ENST00000417570.1_Splice_Site|CLEC17A_ENST00000397439.2_Splice_Site	NM_207390.3	NP_997273.3	Q6ZS10	CL17A_HUMAN	C-type lectin domain family 17, member A							cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity										TGCTGAGCACGTGAGTTCTTC	0.498000													7	25					8.12818e-05	8.58519e-05	1	1	0
FOXL1	2300	broad.mit.edu	37	16	86613242	86613242	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr16:86613242C>T	ENST00000320241.3	+	1	1128	c.913C>T	c.(913-915)Cgt>Tgt	p.R305C		NM_005250.2	NP_005241.1	Q12952	FOXL1_HUMAN	forkhead box L1	305					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(2)|prostate(3)|skin(1)|urinary_tract(1)	15						CTCCAGCCTCCGTCCGCCTTT	0.672000													3	18					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19511697	19511697	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:19511697G>A	ENST00000375267.2	-	15	1837	c.1834C>T	c.(1834-1836)Ccc>Tcc	p.P612S	UBR4_ENST00000375254.3_Missense_Mutation_p.P612S|UBR4_ENST00000375217.2_Missense_Mutation_p.P612S|UBR4_ENST00000375226.2_Missense_Mutation_p.P612S			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	612	Pro-rich.				interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GGAGGTGGGGGAGGAGGCGGA	0.522000													7	161					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	936259	936259	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr12:936259C>G	ENST00000537687.1	+	3	1627	c.984C>G	c.(982-984)tgC>tgG	p.C328W	WNK1_ENST00000535572.1_Missense_Mutation_p.C328W|WNK1_ENST00000530271.2_Missense_Mutation_p.C328W|WNK1_ENST00000447667.2_Missense_Mutation_p.C328W|WNK1_ENST00000315939.6_Missense_Mutation_p.C328W	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	328	Protein kinase.				intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity	p.C328W(1)		breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GAAGCTGGTGCCGTCAGATCC	0.388000													8	89					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631254	32631254	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr9:32631254G>A	ENST00000242310.4	-	1	4413	c.4324C>T	c.(4324-4326)Cgg>Tgg	p.R1442W		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1442	Bromo 1.				male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCCATTGGCCGAGTGATGATT	0.438000													19	131					0	0	1	0	0
C16orf82	162083	broad.mit.edu	37	16	27078280	27078280	+	RNA	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr16:27078280C>G	ENST00000505035.1	+	0	253				RP11-673P17.2_ENST00000565783.1_RNA			Q7Z2V1	TNT_HUMAN																			AGAGAGGTCACAGCCAACATT	0.552000													5	62					0	0	1	0	0
ZBTB11	27107	broad.mit.edu	37	3	101370231	101370231	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr3:101370231G>C	ENST00000312938.4	-	11	3521	c.2941C>G	c.(2941-2943)Caa>Gaa	p.Q981E		NM_014415.3	NP_055230.2	O95625	ZBT11_HUMAN	zinc finger and BTB domain containing 11	981					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						TCAAGTTCTTGAGGACCACTG	0.458000													16	131					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50977010	50977010	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr18:50977010C>T	ENST00000442544.2	+	23	3986	c.3370C>T	c.(3370-3372)Cgc>Tgc	p.R1124C	DCC_ENST00000581580.1_Missense_Mutation_p.R759C	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1124					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TTGCACCCGACGCTCTTCAGC	0.488000													6	35					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33960504	33960504	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:33960504C>G	ENST00000361328.3	+	8	2713	c.2560C>G	c.(2560-2562)Caa>Gaa	p.Q854E		NM_145238.3	NP_660281.2	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	854					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TGAACAACCTCAAAGTATCAG	0.463000													12	170					0	0	1	0	0
SLC25A36	55186	broad.mit.edu	37	3	140675520	140675520	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr3:140675520C>G	ENST00000446041.2	+	2	418	c.193C>G	c.(193-195)Ctt>Gtt	p.L65V	SLC25A36_ENST00000453248.2_Missense_Mutation_p.L65V|SLC25A36_ENST00000507429.1_Missense_Mutation_p.L65V|SLC25A36_ENST00000324194.6_Missense_Mutation_p.L65V|SLC25A36_ENST00000393015.4_3'UTR	NM_001104647.1|NM_018155.2	NP_001098117.1|NP_060625.2	Q96CQ1	S2536_HUMAN	solute carrier family 25 (pyrimidine nucleotide carrier ), member 36	65					response to estradiol stimulus|transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			endometrium(2)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	6						TCCCGGACCTCTTCATTGCCT	0.428000													14	98					0	0	1	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48588339	48588339	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:48588339T>C	ENST00000354276.3	-	10	1148	c.821A>G	c.(820-822)aAa>aGa	p.K274R	PLA2G4C_ENST00000413144.2_Missense_Mutation_p.K274R|PLA2G4C_ENST00000599921.1_Missense_Mutation_p.K274R|PLA2G4C_ENST00000599111.1_Missense_Mutation_p.K284R	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	274	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		TCCAATGCTTTTAGCATTAGC	0.373000													4	44					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101203719	101203719	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:101203719C>T	ENST00000294728.2	+	9	2201	c.2100C>T	c.(2098-2100)ctC>ctT	p.L700L	VCAM1_ENST00000347652.2_Silent_p.L608L|VCAM1_ENST00000370115.1_Silent_p.L501L|VCAM1_ENST00000370119.4_Silent_p.L638L	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	700					heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding	p.L700L(1)		central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	CTGAGCTTCTCGTGCTCTATT	0.338000													20	109					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271673	22271673	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:22271673G>A	ENST00000594947.1	+	4	1265	c.1121G>A	c.(1120-1122)tGt>tAt	p.C374Y		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	374					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				CCCTACAAATGTGAAGAGTGT	0.378000													5	25					0	0	1	0	0
UTP15	84135	broad.mit.edu	37	5	72875907	72875907	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr5:72875907G>T	ENST00000296792.4	+	13	1800	c.1545G>T	c.(1543-1545)aaG>aaT	p.K515N	UTP15_ENST00000508491.1_Missense_Mutation_p.K496N|UTP15_ENST00000543251.1_Missense_Mutation_p.K325N	NM_032175.2	NP_115551.2	Q8TED0	UTP15_HUMAN	UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)	515					rRNA processing	cytoplasm|nucleolus				endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	15		Lung NSC(167;0.00405)|Ovarian(174;0.0129)		OV - Ovarian serous cystadenocarcinoma(47;7.76e-55)		AGAATAAGAAGATAGAATCAT	0.378000													4	54					0.00909568	0.00930803	1	1	0
CYP27B1	1594	broad.mit.edu	37	12	58160780	58160780	+	Silent	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr12:58160780G>A	ENST00000228606.4	-	1	254	c.45C>T	c.(43-45)gtC>gtT	p.V15V	RP11-571M6.13_ENST00000546609.1_RNA	NM_000785.3	NP_000776.1	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B, polypeptide 1	15					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|urinary_tract(1)	15	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	GCGCCCAGCGGACGCGATGGA	0.612000													5	118					0	0	1	0	0
MMP10	4319	broad.mit.edu	37	11	102643601	102643601	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:102643601G>C	ENST00000279441.4	-	8	1239	c.1203C>G	c.(1201-1203)ttC>ttG	p.F401L		NM_002425.2	NP_002416.1	P09238	MMP10_HUMAN	matrix metallopeptidase 10 (stromelysin 2)	401	Hemopexin-like 3.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|liver(2)|lung(6)	22	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		CCGCTGCAAAGAAGTATGTTT	0.383000													9	136					0	0	1	0	0
SNX25	83891	broad.mit.edu	37	4	186283801	186283801	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr4:186283801G>C	ENST00000504273.1	+	18	2672	c.2378G>C	c.(2377-2379)cGc>cCc	p.R793P	SNX25_ENST00000512853.1_3'UTR|SNX25_ENST00000264694.8_Missense_Mutation_p.R793P			Q9H3E2	SNX25_HUMAN	sorting nexin 25	793					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		CAAAATGCCCGCCACGGTATA	0.393000													16	151					0	0	1	0	0
PEX2	5828	broad.mit.edu	37	8	77896226	77896226	+	Silent	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr8:77896226G>A	ENST00000419564.2	-	4	653	c.189C>T	c.(187-189)ttC>ttT	p.F63F	PEX2_ENST00000357039.4_Silent_p.F63F|PEX2_ENST00000522527.1_Silent_p.F63F|PEX2_ENST00000520103.1_Silent_p.F63F	NM_001172087.1	NP_001165558.1	P28328	PEX2_HUMAN	peroxisomal biogenesis factor 2	63					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	14						ATCTCCACAAGAAAACCCATA	0.428000													6	58					0	0	1	0	0
CLK2	1196	broad.mit.edu	37	1	155235737	155235737	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:155235737C>G	ENST00000368361.4	-	8	1162	c.847G>C	c.(847-849)Gat>Cat	p.D283H	CLK2_ENST00000355560.4_Missense_Mutation_p.D281H|CLK2_ENST00000497188.1_5'UTR|CLK2_ENST00000361168.5_Missense_Mutation_p.D282H|CLK2_ENST00000536801.1_Missense_Mutation_p.D283H			P49760	CLK2_HUMAN	CDC-like kinase 2	283	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.D283N(1)		endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGCTTGTTATCATGGAGGACT	0.502000								Other conserved DNA damage response genes					4	80					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47970749	47970749	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr7:47970749T>A	ENST00000289672.2	-	6	739	c.689A>T	c.(688-690)cAg>cTg	p.Q230L		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	230					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GGGCACTCGCTGGGAGCTGGT	0.612000													6	45					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56203977	56203977	+	Missense_Mutation	SNP	G	G	C	rs112151030	byFrequency	TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr18:56203977G>C	ENST00000361673.3	-	5	3655	c.3442C>G	c.(3442-3444)Ctt>Gtt	p.L1148V	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1148							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						GGTGCAGAAAGAGAACCCTGC	0.517000													7	134					0	0	1	0	0
TFB2M	64216	broad.mit.edu	37	1	246704444	246704444	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:246704444C>T	ENST00000366514.4	-	8	1265	c.1080G>A	c.(1078-1080)gaG>gaA	p.E360E		NM_022366.2	NP_071761.1	Q9H5Q4	TFB2M_HUMAN	transcription factor B2, mitochondrial	360					positive regulation of transcription, DNA-dependent|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription cofactor activity			breast(1)|endometrium(1)|kidney(12)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28	all_cancers(71;4.25e-05)|all_epithelial(71;4.92e-06)|Ovarian(71;0.0254)|all_lung(81;0.0272)|Breast(184;0.0318)|Lung NSC(105;0.0376)		OV - Ovarian serous cystadenocarcinoma(106;0.00358)			TAACTACTTTCTCATCCTCCT	0.353000													4	37					0	0	1	0	0
C6orf118	168090	broad.mit.edu	37	6	165715297	165715297	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr6:165715297G>T	ENST00000543069.1	-	2	783	c.202C>A	c.(202-204)Cgc>Agc	p.R68S	C6orf118_ENST00000230301.8_Missense_Mutation_p.R172S			Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	172										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		TCCCTCCTGCGCCATCCAGGA	0.612000													18	35					5.3912e-06	5.88335e-06	1	1	0
NID2	22795	broad.mit.edu	37	14	52520354	52520354	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr14:52520354A>C	ENST00000216286.5	-	5	1371	c.1372T>G	c.(1372-1374)Tta>Gta	p.L458V	NID2_ENST00000541773.1_Missense_Mutation_p.L405V	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	458						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CCTCGACTTAAGGGTGTAGTG	0.493000													20	116					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107553272	107553272	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr9:107553272G>A	ENST00000374736.3	-	44	6252	c.5858C>T	c.(5857-5859)tCa>tTa	p.S1953L		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	1953	ABC transporter 2.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GAAAGTTGATGATTTTCCAGC	0.383000													5	139					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33960512	33960512	+	Silent	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:33960512C>T	ENST00000361328.3	+	8	2721	c.2568C>T	c.(2566-2568)atC>atT	p.I856I		NM_145238.3	NP_660281.2	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	856					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CTCAAAGTATCAGTAAGGACT	0.468000													13	169					0	0	1	0	0
XPO5	57510	broad.mit.edu	37	6	43492249	43492249	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr6:43492249C>T	ENST00000265351.7	-	31	3647	c.3437G>A	c.(3436-3438)cGa>cAa	p.R1146Q	POLR1C_ENST00000304004.3_Intron	NM_020750.2	NP_065801.1	Q9HAV4	XPO5_HUMAN	exportin 5	1146					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(4)|lung(10)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	34	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			TTGGTCCTTTCGGCGCTTGTC	0.488000													11	44					0	0	1	0	0
OR51L1	119682	broad.mit.edu	37	11	5020812	5020812	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:5020812T>A	ENST00000321543.1	+	1	600	c.600T>A	c.(598-600)taT>taA	p.Y200*		NM_001004755.1	NP_001004755.1	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L, member 1	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(19)|skin(2)|stomach(1)	31		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACAGTATTTATGGGCTTTGTG	0.428000													8	55					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95826265	95826265	+	Silent	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:95826265G>A	ENST00000524717.1	-	2	2214	c.930C>T	c.(928-930)ttC>ttT	p.F310F		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	310					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				TCAGTTCATTGAACAGTTCCT	0.453000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								6	74					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27446491	27446491	+	Silent	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:27446491G>C	ENST00000264705.4	+	7	1032	c.870G>C	c.(868-870)ctG>ctC	p.L290L	CAD_ENST00000403525.1_Silent_p.L290L	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	290	GATase (Glutamine amidotransferase).|Glutamine amidotransferase type-1.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity	p.L290L(1)		NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GCTGCTTTCTGACATCCCAGA	0.567000													6	165					0	0	1	0	0
TIGD7	91151	broad.mit.edu	37	16	3350076	3350076	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr16:3350076G>C	ENST00000396862.1	-	2	2367	c.539C>G	c.(538-540)aCa>aGa	p.T180R	TIGD7_ENST00000268674.2_Missense_Mutation_p.T180R	NM_033208.3	NP_149985.2	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	180	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						aaagaggtctgtttcatcccc	0.398000													44	148					0	0	1	0	0
PDK3	5165	broad.mit.edu	37	X	24521477	24521477	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chrX:24521477A>T	ENST00000441463.2	+	4	354	c.354A>T	c.(352-354)agA>agT	p.R118S	PDK3_ENST00000379162.4_Missense_Mutation_p.R118S	NM_001142386.2	NP_001135858.1	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase, isozyme 3	118					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			NS(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TCAGAAATAGACACAATGATG	0.403000													8	15					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49720032	49720032	+	Nonsense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr13:49720032C>G	ENST00000492622.2	+	8	1243	c.938C>G	c.(937-939)tCa>tGa	p.S313*	FNDC3A_ENST00000398316.3_Nonsense_Mutation_p.S257*|FNDC3A_ENST00000541916.1_Nonsense_Mutation_p.S313*	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	313	Fibronectin type-III 1.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		GTTCTGATCTCAAGTACTGGA	0.368000													4	51					0	0	1	0	0
HBM	3042	broad.mit.edu	37	16	216647	216647	+	Silent	SNP	A	A	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr16:216647A>G	ENST00000356815.3	+	3	386	c.366A>G	c.(364-366)caA>caG	p.Q122Q	HBM_ENST00000472539.1_3'UTR	NM_001003938.3	NP_001003938.1	Q6B0K9	HBM_HUMAN	hemoglobin, mu	122						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity						all_cancers(16;1.62e-06)|all_epithelial(16;4.01e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				TGCAAATGCAAGCGGCGTGGG	0.602000													4	22					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101829032	101829032	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr11:101829032G>A	ENST00000263468.8	+	5	910	c.640G>A	c.(640-642)Gtg>Atg	p.V214M	KIAA1377_ENST00000537689.1_Missense_Mutation_p.V15M	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	214							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TAGCAAAAATGTGTTCCAGCT	0.323000													9	153					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113331173	113331173	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr8:113331173A>T	ENST00000297405.5	-	47	7497	c.7253T>A	c.(7252-7254)aTt>aAt	p.I2418N	CSMD3_ENST00000455883.2_Missense_Mutation_p.I2314N|CSMD3_ENST00000343508.3_Missense_Mutation_p.I2378N|CSMD3_ENST00000352409.3_Missense_Mutation_p.I2348N	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2418	Sushi 13.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATACCTAATAATATCACCTAT	0.353000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	28					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4919462	4919462	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr12:4919462C>G	ENST00000433855.1	+	1	1121	c.255C>G	c.(253-255)ttC>ttG	p.F85L	KCNA6_ENST00000280684.3_Missense_Mutation_p.F85L	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	85						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						ACGAGTACTTCTTCGACCGCA	0.632000										HNSCC(72;0.22)			4	84					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15651283	15651283	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr19:15651283G>A	ENST00000269703.2	+	8	893	c.694G>A	c.(694-696)Gct>Act	p.A232T	CYP4F22_ENST00000601005.2_Missense_Mutation_p.A232T	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	232						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						TTATATCTCCGCTATCATTGA	0.552000													8	74					0	0	1	0	0
CCDC18	343099	broad.mit.edu	37	1	93698028	93698028	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:93698028C>T	ENST00000343253.7	+	18	2837	c.2335C>T	c.(2335-2337)Caa>Taa	p.Q779*	CCDC18_ENST00000338949.4_Nonsense_Mutation_p.Q535*|CCDC18_ENST00000557479.1_Nonsense_Mutation_p.Q898*|CCDC18_ENST00000401026.3_Nonsense_Mutation_p.Q780*|CCDC18_ENST00000334652.5_Nonsense_Mutation_p.Q75*|CCDC18_ENST00000421014.2_3'UTR			Q5T9S5	CCD18_HUMAN	coiled-coil domain containing 18	779										breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		TCACAGTCTTCAAGAGACTTC	0.328000													5	56					0	0	1	0	0
LOC81691	81691	broad.mit.edu	37	16	20838439	20838439	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr16:20838439A>G	ENST00000261377.6	+	9	1090	c.881A>G	c.(880-882)cAg>cGg	p.Q294R	AC004381.6_ENST00000348433.6_Missense_Mutation_p.Q294R|ERI2_ENST00000564349.1_Intron|AC004381.6_ENST00000564274.1_Missense_Mutation_p.Q294R	NM_001199053.1|NM_030941.2	NP_001185982.1|NP_112203.2																					AAAGATGTACAGAGGCAGTTA	0.413000													5	78					0	0	1	0	0
RNF113B	140432	broad.mit.edu	37	13	98828834	98828834	+	Silent	SNP	A	A	G			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr13:98828834A>G	ENST00000267291.6	-	1	685	c.657T>C	c.(655-657)gaT>gaC	p.D219D	FARP1_ENST00000595437.1_Intron|FARP1_ENST00000319562.6_Intron|FARP1_ENST00000376586.2_Intron|FARP1_ENST00000376581.5_Intron	NM_178861.4	NP_849192.1	Q8IZP6	R113B_HUMAN	ring finger protein 113B	219							nucleic acid binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			CGAGCTTGTAATCGGAACGGT	0.542000													13	76					0	0	1	0	0
SGPP1	81537	broad.mit.edu	37	14	64165370	64165370	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr14:64165370G>C	ENST00000247225.6	-	2	785	c.691C>G	c.(691-693)Ctt>Gtt	p.L231V		NM_030791.2	NP_110418.1	Q9BX95	SGPP1_HUMAN	sphingosine-1-phosphate phosphatase 1	231						endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	10				OV - Ovarian serous cystadenocarcinoma(108;0.0056)|all cancers(60;0.0141)|BRCA - Breast invasive adenocarcinoma(234;0.103)		CCATATATAAGAGGGTACTAA	0.303000													3	38					0	0	1	0	0
SNPH	9751	broad.mit.edu	37	20	1285974	1285974	+	Missense_Mutation	SNP	G	G	A	rs144751280		TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr20:1285974G>A	ENST00000381867.1	+	7	1535	c.893G>A	c.(892-894)cGg>cAg	p.R298Q	SNPH_ENST00000381873.3_Missense_Mutation_p.R254Q			O15079	SNPH_HUMAN	syntaphilin	254					synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			endometrium(2)|large_intestine(4)|lung(10)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						ACACTGAGCCGGACGGACGCG	0.687000													6	41					0	0	1	0	0
KRTAP12-3	386683	broad.mit.edu	37	21	46077981	46077981	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr21:46077981A>T	ENST00000397907.1	+	1	133	c.85A>T	c.(85-87)Agc>Tgc	p.S29C	TSPEAR_ENST00000323084.4_Intron	NM_198697.2	NP_941970.2	P60328	KR123_HUMAN	keratin associated protein 12-3	29	14 X 5 AA approximate repeats.					intermediate filament				central_nervous_system(1)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						TGTGCCCGTGAGCTGCCAGTC	0.677000													14	89					0	0	1	0	0
STRADB	55437	broad.mit.edu	37	2	202343179	202343179	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr2:202343179G>C	ENST00000194530.3	+	10	1290	c.925G>C	c.(925-927)Gac>Cac	p.D309H	STRADB_ENST00000392249.2_Missense_Mutation_p.D309H	NM_001206864.1|NM_018571.5	NP_001193793.1|NP_061041.2	Q9C0K7	STRAB_HUMAN	STE20-related kinase adaptor beta	309	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|protein binding|protein kinase activity			breast(1)|large_intestine(2)|lung(5)|prostate(1)|skin(3)|stomach(1)	13						GTCAGGTGTAGACTCTGGGAT	0.428000													4	70					0	0	1	0	0
NXF2B	728343	broad.mit.edu	37	X	101623790	101623790	+	Splice_Site	SNP	T	T	C			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chrX:101623790T>C	ENST00000457521.2	-	19	2445		c.e19-2		NXF2B_ENST00000372752.1_Splice_Site|NXF2B_ENST00000412230.2_Splice_Site|NXF2B_ENST00000372749.1_Splice_Site|NXF2B_ENST00000372750.1_Splice_Site					nuclear RNA export factor 2B											breast(1)|kidney(1)|lung(4)|ovary(1)	7						TATACATATCTGCAGGAAGGC	0.493000													4	39					0	0	1	0	0
PIGC	5279	broad.mit.edu	37	1	172411741	172411742	+	Frame_Shift_Ins	INS	-	-	A			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr1:172411741_172411742insA	ENST00000367728.1	-	1	1484_1485	c.21_22insT	c.(19-24)acacacfs	p.H8fs	PIGC_ENST00000484368.1_Intron|PIGC_ENST00000344529.4_Frame_Shift_Ins_p.H8fs|C1orf105_ENST00000367727.4_Intron|PIGC_ENST00000258324.1_Frame_Shift_Ins_p.H8fs			Q92535	PIGC_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class C	8					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			breast(1)|endometrium(1)|kidney(1)|lung(1)	4						TCCTTGGTGTTAGTCACAGGTT	0.455													7	144	---	---	---	---					
ABCA2	20	broad.mit.edu	37	9	139915366	139915366	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr9:139915366delG	ENST00000265662.5	-	9	1192	c.1045delC	c.(1045-1047)agfs	p.Q349fs	ABCA2_ENST00000492260.1_5'UTR|ABCA2_ENST00000371605.3_Frame_Shift_Del_p.Q348fs|ABCA2_ENST00000341511.6_Frame_Shift_Del_p.Q349fs			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	348					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CAGGCACCCTGGGGCAGTAGC	0.711													2	4	---	---	---	---					
CKAP2P1	100420763	broad.mit.edu	37	14	21580890	21580890	+	RNA	DEL	T	T	-			TCGA-D6-A4ZB-01A-11D-A25D-08	TCGA-D6-A4ZB-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20d11092-524f-4f37-b719-86a2d26c6623	97e2d630-2d6e-468b-b029-bf142f618a4c	g.chr14:21580890delT	ENST00000320322.2	+	0	117																											GCTCTGTTGCTTTAGGAATAG	0.373													2	4	---	---	---	---					
