Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MAGEA5	4104	broad.mit.edu	37	X	151283859	151283859	+	RNA	SNP	C	C	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chrX:151283859C>A	ENST00000509345.2	-	0	477																											GCAGGCACCTCCCCCAGGGTG	0.622000													17	47					3.41278e-10	3.96197e-10	1	1	0
CAMTA1	23261	broad.mit.edu	37	1	7724554	7724554	+	Silent	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr1:7724554G>A	ENST00000303635.7	+	9	2154	c.1947G>A	c.(1945-1947)acG>acA	p.T649T	CAMTA1_ENST00000439411.2_Silent_p.T649T	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	649					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CGGTGAAAACGGAGGCCTCGT	0.627000			T	WWTR1	epitheliod hemangioendothelioma								56	304					0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230632383	230632383	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr2:230632383C>G	ENST00000283943.5	-	41	6044	c.5866G>C	c.(5866-5868)Gta>Cta	p.V1956L	TRIP12_ENST00000389044.4_Missense_Mutation_p.V2004L|TRIP12_ENST00000389045.3_Missense_Mutation_p.V1686L	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1956	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CAAGTCATTACAGAGGGCAAG	0.413000													26	76					0	0	1	0	0
PARVB	29780	broad.mit.edu	37	22	44527492	44527492	+	Missense_Mutation	SNP	C	C	T	rs144931273		TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr22:44527492C>T	ENST00000338758.6	+	5	565	c.502C>T	c.(502-504)Cgg>Tgg	p.R168W	PARVB_ENST00000406477.3_Missense_Mutation_p.R201W|PARVB_ENST00000404989.1_Missense_Mutation_p.R131W	NM_013327.4	NP_037459.2	Q9HBI1	PARVB_HUMAN	parvin, beta	168	CH 1.				cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding			NS(1)|breast(1)|endometrium(3)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	25		Ovarian(80;0.0246)|all_neural(38;0.0423)				CTGGGCGCTCCGGTGGAGCGT	0.602000													5	31					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94376929	94376929	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr4:94376929G>T	ENST00000282020.4	+	11	1920	c.1662G>T	c.(1660-1662)aaG>aaT	p.K554N	GRID2_ENST00000510992.1_Missense_Mutation_p.K459N	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	554					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GGGCTGAAAAGACAGTGGATA	0.473000													7	102					0.000157383	0.000167323	1	1	0
MARC1	64757	broad.mit.edu	37	1	220986672	220986672	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr1:220986672G>C	ENST00000366910.5	+	7	1112	c.926G>C	c.(925-927)gGa>gCa	p.G309A	MARC1_ENST00000496110.1_3'UTR	NM_022746.3	NP_073583.3	Q5VT66	MOSC1_HUMAN	mitochondrial amidoxime reducing component 1	309	MOSC.						molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding										AAGTTATATGGAAAATCACCA	0.488000													35	178					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129903554	129903554	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr10:129903554G>C	ENST00000368654.3	-	13	6925	c.6550C>G	c.(6550-6552)Cct>Gct	p.P2184A	MKI67_ENST00000368653.3_Missense_Mutation_p.P1824A	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2184	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTTCCCTTAGGAGTTCTTGGC	0.488000													40	181					0	0	1	0	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114533	27114533	+	Silent	SNP	C	C	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr6:27114533C>A	ENST00000396891.4	-	1	86	c.45G>T	c.(43-45)tcG>tcT	p.S15S	HIST1H2BK_ENST00000356950.1_Silent_p.S15S	NM_080593.2	NP_542160.1	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	15					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						CGGCTTTCTTCGAGCCCTTCT	0.577000													33	179					1.08312e-15	1.27204e-15	1	1	0
WDR13	64743	broad.mit.edu	37	X	48457207	48457207	+	Silent	SNP	A	A	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chrX:48457207A>C	ENST00000218056.5	+	2	649	c.144A>C	c.(142-144)ccA>ccC	p.P48P	WDR13_ENST00000492715.1_3'UTR	NM_001166426.1|NM_017883.4	NP_001159898.1|NP_060353.2	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13	48						cytoplasm|nucleus				endometrium(1)|large_intestine(4)|lung(4)|ovary(2)	11						GGCACCCCCCAGCGCTGCGTC	0.662000													4	13					0	0	1	0	0
DEPTOR	64798	broad.mit.edu	37	8	121015325	121015325	+	Silent	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr8:121015325C>T	ENST00000286234.5	+	6	1030	c.900C>T	c.(898-900)ccC>ccT	p.P300P	DEPTOR_ENST00000518057.1_3'UTR|DEPTOR_ENST00000523492.1_Silent_p.P199P	NM_022783.2	NP_073620.2	Q8TB45	DPTOR_HUMAN	DEP domain containing MTOR-interacting protein	300					intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	18						gcagcagcCCCCCTGTGCTCT	0.612000													4	76					0	0	1	0	0
ZNF135	7694	broad.mit.edu	37	19	58578599	58578599	+	Silent	SNP	A	A	G			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr19:58578599A>G	ENST00000506786.1	+	5	1175	c.621A>G	c.(619-621)aaA>aaG	p.K207K	ZNF135_ENST00000313434.5_Silent_p.K249K|ZNF135_ENST00000439855.2_Silent_p.K249K|ZNF135_ENST00000401053.4_Silent_p.K273K|ZNF135_ENST00000359978.6_Silent_p.K261K|ZNF135_ENST00000511556.1_Silent_p.K261K			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	261					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		AATGCTTAAAAGGCTTCCGGA	0.498000													4	221					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505842	195505842	+	Silent	SNP	T	T	G			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr3:195505842T>G	ENST00000463781.3	-	2	13068	c.12609A>C	c.(12607-12609)acA>acC	p.T4203T	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Silent_p.T4203T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	966					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGGCGTGACCTGTGGATGCTG	0.597000													3	8					0	0	1	0	0
ANKS1A	23294	broad.mit.edu	37	6	35053632	35053632	+	Silent	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr6:35053632G>A	ENST00000360359.3	+	22	3360	c.3222G>A	c.(3220-3222)acG>acA	p.T1074T	ANKS1A_ENST00000535627.1_Intron	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	1074	PID.					cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						CCAGGGCGACGGGCGCCTCTG	0.607000													17	47					0	0	1	0	0
CARD10	29775	broad.mit.edu	37	22	37891880	37891880	+	Silent	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr22:37891880C>T	ENST00000403299.1	-	15	2406	c.2190G>A	c.(2188-2190)gaG>gaA	p.E730E	CARD10_ENST00000251973.5_Silent_p.E730E|CARD10_ENST00000406271.3_Silent_p.E444E			Q9BWT7	CAR10_HUMAN	caspase recruitment domain family, member 10	730					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	17	Melanoma(58;0.0574)					GTCGAAGGATCTCTTGGGCTT	0.627000													6	72					0	0	1	0	0
ANKIB1	54467	broad.mit.edu	37	7	92027950	92027950	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr7:92027950C>T	ENST00000265742.3	+	20	3333	c.2957C>T	c.(2956-2958)gCc>gTc	p.A986V		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	986							protein binding|zinc ion binding			cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAGAGTATTGCCCTGATTCCT	0.498000													22	110					0	0	1	0	0
BAIAP3	8938	broad.mit.edu	37	16	1388958	1388958	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr16:1388958G>T	ENST00000324385.5	+	3	450	c.292G>T	c.(292-294)Ggg>Tgg	p.G98W	BAIAP3_ENST00000568887.1_Missense_Mutation_p.G63W|BAIAP3_ENST00000397489.1_Missense_Mutation_p.G63W|BAIAP3_ENST00000421665.2_Missense_Mutation_p.G63W|BAIAP3_ENST00000426824.3_Missense_Mutation_p.G63W|BAIAP3_ENST00000397488.2_Missense_Mutation_p.G63W|BAIAP3_ENST00000562208.1_Missense_Mutation_p.G63W	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	98					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				GCTGAAGAAGGGGGAAGGCAG	0.657000													22	171					1.22574e-08	1.39101e-08	1	1	0
INO80D	54891	broad.mit.edu	37	2	206882489	206882489	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr2:206882489T>C	ENST00000403263.1	-	8	1861	c.1457A>G	c.(1456-1458)aAg>aGg	p.K486R		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	486					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						ATCTGCAAACTTGGCTGTGCA	0.398000													8	27					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43268418	43268418	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr19:43268418A>T	ENST00000404209.4	-	2	176	c.80T>A	c.(79-81)tTc>tAc	p.F27Y	PSG8_ENST00000406636.3_Intron|PSG8_ENST00000401467.2_Missense_Mutation_p.F27Y|PSG8_ENST00000306511.4_Missense_Mutation_p.F27Y	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	27						extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				TGGGTTCCAGAAGTTTAAAAG	0.488000													34	163					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75981297	75981297	+	Silent	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr15:75981297G>A	ENST00000308508.5	-	3	2201	c.2109C>T	c.(2107-2109)gtC>gtT	p.V703V		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	703	Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GGGCCCCAGTGACGCGGAACA	0.667000													5	178					0	0	1	0	0
ISM1	140862	broad.mit.edu	37	20	13260439	13260439	+	Silent	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr20:13260439G>A	ENST00000262487.3	+	3	543	c.537G>A	c.(535-537)aaG>aaA	p.K179K	TASP1_ENST00000539805.1_Intron	NM_080826.1	NP_543016.1	B1AKI9	ISM1_HUMAN	isthmin 1, angiogenesis inhibitor	179						extracellular region				NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(8)|lung(5)|urinary_tract(1)	17						AGGACTACAAGTACGACAGTA	0.612000													23	90					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229647	140229647	+	Silent	SNP	T	T	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr5:140229647T>C	ENST00000378122.3	+	1	2291	c.1567T>C	c.(1567-1569)Ttg>Ctg	p.L523L	PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA9_ENST00000532602.1_Silent_p.L523L|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGCAGCCGTTGGACCACGA	0.682000													6	350					0	0	1	0	0
B3GNT3	10331	broad.mit.edu	37	19	17918691	17918691	+	Silent	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr19:17918691C>T	ENST00000318683.6	+	2	222	c.75C>T	c.(73-75)ttC>ttT	p.F25F	B3GNT3_ENST00000595387.1_Silent_p.F25F	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	25					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						TCCTCCTCTTCAGTCTGCTAG	0.687000													12	62					0	0	1	0	0
SCUBE3	222663	broad.mit.edu	37	6	35213155	35213155	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr6:35213155T>C	ENST00000274938.7	+	19	2552	c.2552T>C	c.(2551-2553)cTg>cCg	p.L851P	SCUBE3_ENST00000394681.1_Missense_Mutation_p.L867P	NM_152753.2	NP_689966.2	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	851	CUB.				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	37						GAGATCTTCCTGCCATCTGAG	0.567000													8	72					0	0	1	0	0
LOC645166	645166	broad.mit.edu	37	1	148932911	148932911	+	RNA	SNP	G	G	A	rs2531445	by1000genomes	TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr1:148932911G>A	ENST00000539543.1	+	0	167					NR_027355.1																						CCAAGACTCCGTCCTGCAAGG	0.612000													11	262					0	0	1	0	0
CCDC171	203238	broad.mit.edu	37	9	15784679	15784679	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr9:15784679G>C	ENST00000380701.3	+	21	3582	c.3254G>C	c.(3253-3255)gGa>gCa	p.G1085A	CCDC171_ENST00000297641.3_Missense_Mutation_p.G1085A	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171	1085																	CAAACTCTTGGAGAAGCTGTT	0.358000													12	49					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr16:90162513T>C	ENST00000564451.1	+	0	1866				TUBB8P7_ENST00000567960.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													4	107					0	0	1	0	0
GFM1	85476	broad.mit.edu	37	3	158363534	158363534	+	Silent	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr3:158363534C>T	ENST00000486715.1	+	2	555	c.198C>T	c.(196-198)gtC>gtT	p.V66V	GFM1_ENST00000478576.1_Silent_p.V66V|GFM1_ENST00000264263.5_Silent_p.V66V	NM_024996.5	NP_079272.4	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1	66					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|urinary_tract(2)	22			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CAGAACGAGTCCTTTACTACA	0.363000													7	104					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155630074	155630074	+	Nonsense_Mutation	SNP	T	T	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr1:155630074T>A	ENST00000368340.5	-	10	2089	c.1981A>T	c.(1981-1983)Aaa>Taa	p.K661*	YY1AP1_ENST00000535662.1_Nonsense_Mutation_p.K389*|YY1AP1_ENST00000407221.1_Nonsense_Mutation_p.K512*|YY1AP1_ENST00000295566.4_Nonsense_Mutation_p.K589*|YY1AP1_ENST00000368339.5_Nonsense_Mutation_p.K681*|YY1AP1_ENST00000368330.2_Nonsense_Mutation_p.K543*|YY1AP1_ENST00000347088.5_Nonsense_Mutation_p.K543*|YY1AP1_ENST00000361831.5_Nonsense_Mutation_p.K532*|YY1AP1_ENST00000355499.4_Nonsense_Mutation_p.K543*|YY1AP1_ENST00000311573.5_Nonsense_Mutation_p.K512*|YY1AP1_ENST00000359205.5_Nonsense_Mutation_p.K532*|YY1AP1_ENST00000404643.1_Nonsense_Mutation_p.K523*|MSTO1_ENST00000538143.1_Intron|MSTO1_ENST00000452804.2_Intron	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					GGGGCAGGTTTGATACAGCGA	0.522000													11	171					0	0	1	0	0
BHLHE41	79365	broad.mit.edu	37	12	26276085	26276085	+	Silent	SNP	T	T	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr12:26276085T>C	ENST00000242728.4	-	5	710	c.363A>G	c.(361-363)aaA>aaG	p.K121K		NM_030762.2	NP_110389.1	Q9C0J9	BHE41_HUMAN	basic helix-loop-helix family, member e41	121					cell differentiation|cell proliferation|organ morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(1)	5						GAATGGGCGATTTCAGAGATC	0.527000											OREG0021711	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	22					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65365202	65365202	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr3:65365202G>A	ENST00000330909.8	-	18	2812	c.2813C>T	c.(2812-2814)tCg>tTg	p.S938L	MAGI1_ENST00000483466.1_Missense_Mutation_p.S938L|MAGI1_ENST00000497477.2_Missense_Mutation_p.S910L|MAGI1_ENST00000402939.2_Missense_Mutation_p.S910L	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	938					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GGAGGCTGGCGAGGGCACCTC	0.627000													38	153					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122423459	122423459	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr3:122423459G>A	ENST00000474629.2	+	8	3670	c.3404G>A	c.(3403-3405)gGa>gAa	p.G1135E		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1135	Macro 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		ATAGGAACAGGAAACTTGGGA	0.358000													4	15					0	0	1	0	0
ENG	2022	broad.mit.edu	37	9	130605480	130605480	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr9:130605480C>T	ENST00000344849.3	-	2	392	c.112G>A	c.(112-114)Gag>Aag	p.E38K	ENG_ENST00000373203.4_Missense_Mutation_p.E38K			P17813	EGLN_HUMAN	endoglin	38					artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	17						TCGCCCCTCTCGGGGCCCACA	0.547000									Juvenile Polyposis;Hereditary Hemorrhagic Telangiectasia				22	127					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164725727	164725727	+	Silent	SNP	G	G	A	rs138374817		TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr3:164725727G>A	ENST00000264382.3	-	36	4301	c.4239C>T	c.(4237-4239)gaC>gaT	p.D1413D		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1413	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AATTTAGTTCGTCATTTCTGC	0.259000										HNSCC(35;0.089)			17	57					0	0	1	0	0
CRTC1	23373	broad.mit.edu	37	19	18856686	18856686	+	Silent	SNP	G	G	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr19:18856686G>T	ENST00000338797.6	+	4	370	c.345G>T	c.(343-345)ggG>ggT	p.G115G	CRTC1_ENST00000321949.8_Silent_p.G99G|CRTC1_ENST00000601916.1_Silent_p.G24G|CRTC1_ENST00000594658.1_Silent_p.G58G	NM_001098482.1	NP_001091952.1	Q6UUV9	CRTC1_HUMAN	CREB regulated transcription coactivator 1	99					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	19						GGCACCATGGGCTGGTGGACA	0.632000													9	142					9.70103e-10	1.11341e-09	1	1	0
KLHDC7A	127707	broad.mit.edu	37	1	18809727	18809727	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr1:18809727G>A	ENST00000400664.1	+	1	2304	c.2252G>A	c.(2251-2253)cGg>cAg	p.R751Q		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	751						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		AAGGAGCTGCGGAGTTTCCCG	0.642000													25	122					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505851	195505851	+	Silent	SNP	T	T	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr3:195505851T>C	ENST00000463781.3	-	2	13059	c.12600A>G	c.(12598-12600)tcA>tcG	p.S4200S	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Silent_p.S4200S	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	963					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CTGTGGATGCTGAGGAAGTGT	0.592000													3	5					0	0	1	0	0
VPS37A	137492	broad.mit.edu	37	8	17133958	17133958	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr8:17133958C>G	ENST00000324849.4	+	6	1369	c.695C>G	c.(694-696)cCa>cGa	p.P232R	VPS37A_ENST00000521829.1_Missense_Mutation_p.P207R	NM_001145152.1|NM_152415.2	NP_001138624.1|NP_689628.2	Q8NEZ2	VP37A_HUMAN	vacuolar protein sorting 37 homolog A (S. cerevisiae)	232					cellular membrane organization|endosome transport|protein transport	centrosome|late endosome membrane|nucleus				autonomic_ganglia(1)|breast(1)|kidney(2)|large_intestine(1)|lung(4)|skin(1)	10				Colorectal(111;0.0553)|COAD - Colon adenocarcinoma(73;0.212)		GATGCATTTCCAGAACTCTCA	0.313000													5	38					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125875682	125875682	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr11:125875682A>G	ENST00000392693.3	-	9	1950	c.1823T>C	c.(1822-1824)aTc>aCc	p.I608T	CDON_ENST00000263577.7_Missense_Mutation_p.I608T	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	608	Fibronectin type-III 1.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		GTAAGCATTGATGGGCAGCCC	0.493000													9	57					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65268705	65268705	+	RNA	SNP	G	G	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr11:65268705G>T	ENST00000534336.1	+	0	3473					NR_002819.2																						ATTTTTTTTTGTGGGGGTGGG	0.393000													6	22					4.68919e-08	5.20448e-08	1	1	0
FMN2	56776	broad.mit.edu	37	1	240497499	240497499	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr1:240497499G>T	ENST00000319653.9	+	13	4965	c.4735G>T	c.(4735-4737)Gat>Tat	p.D1579Y	FMN2_ENST00000545751.1_Missense_Mutation_p.D175Y	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1579	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TTTTCAAAAAGATCTCAGAAA	0.378000													30	148					8.16721e-17	9.70456e-17	1	1	0
PTPRB	5787	broad.mit.edu	37	12	70988277	70988277	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr12:70988277G>T	ENST00000334414.6	-	6	1530	c.1486C>A	c.(1486-1488)Caa>Aaa	p.Q496K	PTPRB_ENST00000261266.5_Missense_Mutation_p.Q278K|PTPRB_ENST00000551525.1_Missense_Mutation_p.Q495K|PTPRB_ENST00000550358.1_Missense_Mutation_p.Q496K|PTPRB_ENST00000550857.1_Missense_Mutation_p.Q278K|PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000451516.2_Missense_Mutation_p.Q278K|PTPRB_ENST00000538708.1_Missense_Mutation_p.Q278K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	278	Fibronectin type-III 6.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTGTAGTTTTGCAGCCCTGCA	0.458000													13	47					1.5842e-08	1.77782e-08	1	1	0
HERC1	8925	broad.mit.edu	37	15	63904614	63904614	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr15:63904614C>T	ENST00000443617.2	-	77	14323	c.14236G>A	c.(14236-14238)Gag>Aag	p.E4746K		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4746	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TCATCCACCTCACGGTACCGC	0.552000													18	111					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56473842	56473842	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr6:56473842T>C	ENST00000370754.5	-	39	5484	c.5485A>G	c.(5485-5487)Agc>Ggc	p.S1829G	DST_ENST00000370769.4_Missense_Mutation_p.S1651G|DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000361203.3_Missense_Mutation_p.S1651G|DST_ENST00000312431.6_Missense_Mutation_p.S1651G|DST_ENST00000244364.6_Intron|DST_ENST00000446842.2_Missense_Mutation_p.S1325G			Q03001	DYST_HUMAN	dystonin	1651					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GTTATCATGCTTTGAGCTAGA	0.428000													51	232					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75981291	75981291	+	Silent	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr15:75981291C>T	ENST00000308508.5	-	3	2207	c.2115G>A	c.(2113-2115)ggG>ggA	p.G705G		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	705	Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						ACTGCAGGGCCCCAGTGACGC	0.667000													5	181					0	0	1	0	0
NEDD1	121441	broad.mit.edu	37	12	97339486	97339486	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr12:97339486C>T	ENST00000266742.4	+	14	2009	c.1670C>T	c.(1669-1671)tCt>tTt	p.S557F	NEDD1_ENST00000411739.2_Missense_Mutation_p.S468F|NEDD1_ENST00000557644.1_Missense_Mutation_p.S564F|NEDD1_ENST00000429527.2_Missense_Mutation_p.S557F|NEDD1_ENST00000457368.2_Missense_Mutation_p.S468F	NM_152905.3	NP_690869.1	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally down-regulated 1	557					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol				breast(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)	22						AAGATAGCATCTTCTGTCACT	0.363000													9	35					0	0	1	0	0
AGAP7	653268	broad.mit.edu	37	10	51464838	51464838	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr10:51464838T>C	ENST00000374095.5	-	7	1743	c.1618A>G	c.(1618-1620)Aag>Gag	p.K540E		NM_001077685.1	NP_001071153.1	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 7	540	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	11						CACCGTTCCTTCTCTTCCCTC	0.572000													22	215					0	0	1	0	0
HIST1H4G	8369	broad.mit.edu	37	6	26247100	26247100	+	Silent	SNP	G	G	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr6:26247100G>T	ENST00000244537.4	-	1	159	c.106C>A	c.(106-108)Cgg>Agg	p.R36R		NM_003547.2	NP_003538.1	Q99525	H4G_HUMAN	histone cluster 1, H4g	36					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				GCCAAGCGCCGGATAGTGCAC	0.562000													9	61					1.12685e-05	1.22378e-05	1	1	0
ADM2	79924	broad.mit.edu	37	22	50921173	50921173	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr22:50921173G>A	ENST00000362068.2	+	2	553	c.38G>A	c.(37-39)cGg>cAg	p.R13Q	ADM2_ENST00000395737.1_Silent_p.S96S|ADM2_ENST00000395738.2_Silent_p.S96S			Q7Z4H4	ADM2_HUMAN	adrenomedullin 2	48					positive regulation of angiogenesis	extracellular region	hormone activity			breast(1)|kidney(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GAAGACACTCGGGCCCCCGCA	0.697000													9	18					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75981284	75981284	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr15:75981284G>T	ENST00000308508.5	-	3	2214	c.2122C>A	c.(2122-2124)Cag>Aag	p.Q708K		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	708	Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						TCCCCAAACTGCAGGGCCCCA	0.672000													6	181					0.00307968	0.00324008	1	1	0
TPO	7173	broad.mit.edu	37	2	1491667	1491667	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr2:1491667G>A	ENST00000345913.4	+	10	1763	c.1672G>A	c.(1672-1674)Gag>Aag	p.E558K	TPO_ENST00000497517.2_Intron|TPO_ENST00000349624.3_Missense_Mutation_p.E385K|TPO_ENST00000329066.4_Missense_Mutation_p.E558K|TPO_ENST00000337415.3_Missense_Mutation_p.E558K|TPO_ENST00000346956.3_Missense_Mutation_p.E558K|TPO_ENST00000382198.1_Missense_Mutation_p.E385K|TPO_ENST00000382201.3_Intron	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	558					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity	p.E558K(1)		breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCTGATGAACGAGGAGCTGAC	0.562000													16	72					0	0	1	0	0
FAM86DP	692099	broad.mit.edu	37	3	75475607	75475607	+	RNA	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr3:75475607C>T	ENST00000459803.1	-	0	922					NR_024241.1																						TCACCTAGCTCGGTGGTGAAC	0.652000													5	62					0	0	1	0	0
APMAP	57136	broad.mit.edu	37	20	24950953	24950953	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr20:24950953G>A	ENST00000217456.2	-	6	883	c.593C>T	c.(592-594)tCc>tTc	p.S198F	APMAP_ENST00000447138.1_Missense_Mutation_p.S198F	NM_020531.2	NP_065392.1			adipocyte plasma membrane associated protein																		ATTCACAAAGGACATGTTCTT	0.428000													21	122					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70079796	70079796	+	Silent	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr4:70079796G>A	ENST00000446444.1	-	1	653	c.645C>T	c.(643-645)atC>atT	p.I215I	RP11-704M14.1_ENST00000504301.1_RNA|RP11-704M14.1_ENST00000505646.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	215					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						AAAGCACATAGATCATATTTT	0.348000													9	66					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166848095	166848095	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr2:166848095T>C	ENST00000423058.2	-	26	5707	c.5690A>G	c.(5689-5691)aAt>aGt	p.N1897S	AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.N1897S|SCN1A_ENST00000409050.1_Missense_Mutation_p.N1869S|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.N1886S	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1897						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CTTGGAAGGATTGGAAGCCAT	0.428000													16	85					0	0	1	0	0
KRTAP20-2	337976	broad.mit.edu	37	21	32007656	32007656	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr21:32007656G>C	ENST00000330798.2	+	1	102	c.74G>C	c.(73-75)gGc>gCc	p.G25A		NM_181616.1	NP_853647.1	Q3LI61	KR202_HUMAN	keratin associated protein 20-2	25						intermediate filament				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(2)|ovary(1)	8						TATGGCTGTGGCTGTGGTTAT	0.547000													10	129					0	0	1	0	0
CHRM4	1132	broad.mit.edu	37	11	46406910	46406910	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr11:46406910G>A	ENST00000433765.2	-	1	1197	c.1198C>T	c.(1198-1200)Cga>Tga	p.R400*		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	400					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	AAGATCGTTCGTGTCACTTTG	0.617000													9	76					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32635518	32635518	+	Silent	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr11:32635518C>T	ENST00000335185.5	-	16	2389	c.2346G>A	c.(2344-2346)gaG>gaA	p.E782E		NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	782										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					CATGACTATTCTCATTGTTAA	0.323000													7	32					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149502614	149502614	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr5:149502614G>A	ENST00000261799.4	-	15	2643	c.2174C>T	c.(2173-2175)cCc>cTc	p.P725L		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	725	Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCTGGGCAGGGGGAGCCCAAC	0.637000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								8	156					0	0	1	0	0
MAPKAP1	79109	broad.mit.edu	37	9	128246829	128246829	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr9:128246829G>A	ENST00000265960.3	-	9	1432	c.1100C>T	c.(1099-1101)tCg>tTg	p.S367L	MAPKAP1_ENST00000394063.1_Missense_Mutation_p.S175L|MAPKAP1_ENST00000350766.3_Missense_Mutation_p.S331L|MAPKAP1_ENST00000373498.1_Missense_Mutation_p.S367L|MAPKAP1_ENST00000373503.3_Missense_Mutation_p.S175L|MAPKAP1_ENST00000373511.2_Intron|MAPKAP1_ENST00000373497.5_Missense_Mutation_p.S80L	NM_001006617.1	NP_001006618.1	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated protein 1	367					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(15)|ovary(3)	23						GTCAATTTGCGAATCCTCCTC	0.453000													13	57					0	0	1	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113655241	113655241	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr3:113655241C>G	ENST00000358160.4	+	14	2077	c.1585C>G	c.(1585-1587)Cag>Gag	p.Q529E	GRAMD1C_ENST00000452134.2_Missense_Mutation_p.Q258E|GRAMD1C_ENST00000440446.2_Missense_Mutation_p.Q324E|GRAMD1C_ENST00000479212.1_3'UTR|GRAMD1C_ENST00000472026.1_Missense_Mutation_p.Q362E	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	529						integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						ACTTTCCTCTCAGCATTCCTC	0.428000													17	114					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2058446	2058446	+	Silent	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr9:2058446G>A	ENST00000382203.1	+	8	1712	c.1503G>A	c.(1501-1503)gaG>gaA	p.E501E	SMARCA2_ENST00000382194.1_Silent_p.E501E|SMARCA2_ENST00000349721.2_Silent_p.E501E|SMARCA2_ENST00000357248.2_Silent_p.E501E			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	501	HSA.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		TTGAAAAGGAGAGAATGCGGC	0.512000													17	133					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51175382	51175382	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr16:51175382G>A	ENST00000440970.1	-	2	891	c.460C>T	c.(460-462)Cgt>Tgt	p.R154C	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.R251C	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	251	Poly-Ser.				adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R251C(1)		NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ATTTGGTGACGAATCTGTTCG	0.532000													14	120					0	0	1	0	0
KGFLP2	654466	broad.mit.edu	37	9	41962620	41962620	+	RNA	SNP	G	G	A	rs137865170	by1000genomes	TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr9:41962620G>A	ENST00000454645.1	-	0	884					NR_003670.1																						TCCTCTTACAGGAATCCCCTT	0.363000													4	34					0	0	1	0	0
KRTAP4-12	83755	broad.mit.edu	37	17	39279791	39279791	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr17:39279791C>T	ENST00000394014.1	-	1	628	c.584G>A	c.(583-585)tGc>tAc	p.C195Y		NM_031854.2	NP_114060.1	Q9BQ66	KR412_HUMAN	keratin associated protein 4-12	195						keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GGAGGCACAGCACAAGGGGCG	0.572000													6	18					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16327921	16327921	+	Missense_Mutation	SNP	C	C	A	rs142039862	by1000genomes	TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr6:16327921C>A	ENST00000244769.4	-	8	1557	c.621G>T	c.(619-621)caG>caT	p.Q207H	ATXN1_ENST00000436367.1_Missense_Mutation_p.Q207H	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	207	Poly-Gln.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association	p.Q207H(2)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				gctgatgctgctgctgctgct	0.662000													5	21					3.59834e-05	3.8663e-05	1	1	0
ASXL3	80816	broad.mit.edu	37	18	31319576	31319576	+	Silent	SNP	C	C	G			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr18:31319576C>G	ENST00000269197.5	+	11	2208	c.2208C>G	c.(2206-2208)ctC>ctG	p.L736L		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	736	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CCATGCTTCTCACCTCTGAGA	0.408000													12	260					0	0	1	0	0
ABR	29	broad.mit.edu	37	17	910416	910416	+	Missense_Mutation	SNP	C	C	T	rs111816976		TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr17:910416C>T	ENST00000544583.2	-	22	2940	c.2341G>A	c.(2341-2343)Gtc>Atc	p.V781I	ABR_ENST00000291107.2_Missense_Mutation_p.V790I|ABR_ENST00000574437.1_Missense_Mutation_p.V781I|ABR_ENST00000572441.1_Intron|ABR_ENST00000543210.2_Missense_Mutation_p.V278I|ABR_ENST00000536794.2_Missense_Mutation_p.V609I|ABR_ENST00000302538.5_Missense_Mutation_p.V827I	NM_001159746.2	NP_001153218.1	Q12979	ABR_HUMAN	active BCR-related	827	Rho-GAP.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		TGCGCCATGACGTCATGGGAC	0.662000													6	87					0	0	1	0	0
PMS2P3	5387	broad.mit.edu	37	7	75157034	75157034	+	RNA	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr7:75157034C>T	ENST00000418756.1	-	0	419					NR_028059.1															lung(1)	1						GGGCCCGGGCCGGGCCTACGG	0.721000													4	11					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230586	140230586	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr5:140230586C>G	ENST00000378122.3	+	1	3230	c.2506C>G	c.(2506-2508)Cag>Gag	p.Q836E	PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAATCCAGCAGATTTTTTT	0.274000													24	179					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20836706	20836706	+	Nonsense_Mutation	SNP	G	G	A	rs151082585	by1000genomes	TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr14:20836706G>A	ENST00000262715.5	-	55	7814	c.7774C>T	c.(7774-7776)Cga>Tga	p.R2592*	TEP1_ENST00000556935.1_Nonsense_Mutation_p.R2484*	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	2592					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CCTTCGCATCGGAACAGGCCC	0.502000													11	60					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803543	142803543	+	RNA	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr1:142803543C>T	ENST00000423385.1	-	0	1422																											TGTTGGAATTCCTGATGAATC	0.269000													4	139					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152420376	152420376	+	Silent	SNP	G	G	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr2:152420376G>T	ENST00000397345.3	-	118	18742	c.18540C>A	c.(18538-18540)ccC>ccA	p.P6180P	NEB_ENST00000427231.2_Silent_p.P6180P|NEB_ENST00000409198.1_Silent_p.P4479P|NEB_ENST00000604864.1_Silent_p.P6180P|NEB_ENST00000172853.10_Silent_p.P4479P|NEB_ENST00000603639.1_Silent_p.P6180P	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	6169					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTCCAACAATGGGAATGTAGC	0.483000													3	37					0.115264	0.116417	1	1	0
ZIC3	7547	broad.mit.edu	37	X	136649867	136649867	+	Silent	SNP	T	T	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chrX:136649867T>C	ENST00000287538.5	+	1	1567	c.1017T>C	c.(1015-1017)ttT>ttC	p.F339F	ZIC3_ENST00000370606.3_Silent_p.F339F	NM_003413.3	NP_003404.1	O60481	ZIC3_HUMAN	Zic family member 3	339	Nuclear localization signal.				cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|soft_tissue(2)|urinary_tract(1)	37	Acute lymphoblastic leukemia(192;0.000127)					GGAAGATCTTTGCCCGTTCTG	0.587000													8	159					0	0	1	0	0
GFRA3	2676	broad.mit.edu	37	5	137593486	137593486	+	Silent	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr5:137593486C>T	ENST00000274721.3	-	4	873	c.627G>A	c.(625-627)gaG>gaA	p.E209E	GFRA3_ENST00000378362.3_Silent_p.E178E	NM_001496.3	NP_001487.2	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3	209					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GCGCGTGGGGCTCGGCGGCCT	0.731000													13	58					0	0	1	0	0
OR5M9	390162	broad.mit.edu	37	11	56230199	56230199	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr11:56230199G>A	ENST00000279791.1	-	1	678	c.679C>T	c.(679-681)Cgc>Tgc	p.R227C		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					TCGGCAGAGCGCATGCGTAGC	0.488000													4	29					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64467347	64467347	+	Translation_Start_Site	SNP	A	A	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr14:64467347A>T	ENST00000357395.3	+	0	3778				SYNE2_ENST00000358025.3_Missense_Mutation_p.H1183L|SYNE2_ENST00000344113.4_Missense_Mutation_p.H1183L|SYNE2_ENST00000554584.1_Missense_Mutation_p.H1183L			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2						centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTAGAAAATCATGTGAATGAC	0.303000													14	61					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111862863	111862863	+	Silent	SNP	G	G	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr1:111862863G>A	ENST00000369740.1	+	12	1309	c.1206G>A	c.(1204-1206)gaG>gaA	p.E402E	CHIA_ENST00000430615.1_Silent_p.E294E|CHIA_ENST00000483391.1_Silent_p.E241E|CHIA_ENST00000451398.2_Silent_p.E241E|RP5-1125M8.2_ENST00000426321.1_RNA|CHIA_ENST00000343320.6_Silent_p.E402E|CHIA_ENST00000353665.6_Silent_p.E241E	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	402					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		AGCCCATTGAGCCAATAACTG	0.582000													19	72					0	0	1	0	0
MON1A	84315	broad.mit.edu	37	3	49948253	49948253	+	Silent	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr3:49948253C>T	ENST00000417270.1	-	5	1395	c.702G>A	c.(700-702)cgG>cgA	p.R234R	MON1A_ENST00000296473.3_Silent_p.R323R|MON1A_ENST00000455683.2_Silent_p.R161R|CTD-2330K9.3_ENST00000419183.1_Intron			Q86VX9	MON1A_HUMAN	MON1 secretory trafficking family member A	226							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GTGCCGACTGCCGCGTACGAG	0.592000													3	36					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55027486	55027486	+	Silent	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr20:55027486C>T	ENST00000371336.3	+	5	1455	c.1254C>T	c.(1252-1254)acC>acT	p.T418T	CASS4_ENST00000434344.1_Intron|CASS4_ENST00000360314.3_Silent_p.T418T	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	418	Ser-rich.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						CCACATCCACCGACGACTCCT	0.567000													3	41					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94376882	94376882	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr4:94376882C>A	ENST00000282020.4	+	11	1873	c.1615C>A	c.(1615-1617)Cgt>Agt	p.R539S	GRID2_ENST00000510992.1_Missense_Mutation_p.R444S	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	539					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity	p.R539C(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CTTTACGACACGTTACATGGA	0.438000													7	110					2.0095e-06	2.20608e-06	1	1	0
ZNF813	126017	broad.mit.edu	37	19	53995284	53995284	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr19:53995284C>A	ENST00000396403.4	+	4	1926	c.1798C>A	c.(1798-1800)Ctt>Att	p.L600I	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	600					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TCATCATAGACTTCATACTGG	0.368000													3	36					0.115264	0.116417	1	1	0
POPDC3	64208	broad.mit.edu	37	6	105607694	105607694	+	Splice_Site	SNP	C	C	A	rs149894294		TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr6:105607694C>A	ENST00000254765.3	-	3	764	c.485_splice	c.e3-1	p.R162_splice	BVES-AS1_ENST00000580854.1_RNA|POPDC3_ENST00000474760.1_5'UTR|BVES-AS1_ENST00000580511.1_RNA|BVES-AS1_ENST00000369122.3_RNA	NM_022361.4	NP_071756.2	Q9HBV1	POPD3_HUMAN	popeye domain containing 3	162						integral to membrane				NS(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(3)|urinary_tract(1)	26		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				TCACTCTGATCCTATCAAAAC	0.463000													4	46					0.00909568	0.00937412	1	1	0
TP53	7157	broad.mit.edu	37	17	7578479	7578479	+	Missense_Mutation	SNP	G	G	A	rs28934874		TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr17:7578479G>A	ENST00000420246.2	-	5	583	c.451C>T	c.(451-453)Ccc>Tcc	p.P151S	TP53_ENST00000455263.2_Missense_Mutation_p.P151S|TP53_ENST00000269305.4_Missense_Mutation_p.P151S|TP53_ENST00000359597.4_Missense_Mutation_p.P151S|TP53_ENST00000445888.2_Missense_Mutation_p.P151S|TP53_ENST00000413465.2_Missense_Mutation_p.P151S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	151	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> A (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934874).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(68)|p.P151T(16)|p.P151A(13)|p.P152fs*18(9)|p.0?(8)|p.T150fs*16(6)|p.P151fs*30(6)|p.?(5)|p.P58A(2)|p.P58S(2)|p.P19A(2)|p.P19S(2)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P152fs*28(1)|p.T57fs*16(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.P58T(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.Q144fs*16(1)|p.P19T(1)|p.P152fs*14(1)|p.T18fs*16(1)|p.T150_P151delTP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGGCGGGGGTGTGGAATCA	0.612000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			29	61					0	0	1	0	0
IL17RD	54756	broad.mit.edu	37	3	57131801	57131801	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr3:57131801G>T	ENST00000296318.7	-	12	2018	c.1930C>A	c.(1930-1932)Caa>Aaa	p.Q644K	IL17RD_ENST00000463523.1_Missense_Mutation_p.Q500K|IL17RD_ENST00000427856.2_Missense_Mutation_p.Q620K|IL17RD_ENST00000320057.5_Missense_Mutation_p.Q500K	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	644						Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		AGCAGGGGTTGCAGGGCGGCG	0.682000													3	29					0.004672	0.00486466	1	1	0
MTTP	4547	broad.mit.edu	37	4	100534246	100534246	+	Silent	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr4:100534246C>T	ENST00000457717.1	+	16	2422	c.2166C>T	c.(2164-2166)ggC>ggT	p.G722G	MTTP_ENST00000511045.1_Silent_p.G749G|MTTP_ENST00000265517.5_Silent_p.G722G|RP11-766F14.1_ENST00000508578.1_RNA	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	722					lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	CAGCATCTGGCGACCCTATCA	0.423000													13	43					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8399557	8399557	+	Silent	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr1:8399557C>T	ENST00000471889.1	+	8	2164	c.1779C>T	c.(1777-1779)atC>atT	p.I593I	SLC45A1_ENST00000377479.2_Silent_p.I627I|SLC45A1_ENST00000289877.8_Silent_p.I593I			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	593					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCGCAGCTATCCTGGAGAAGC	0.652000													11	87					0	0	1	0	0
HLA-B	3106	broad.mit.edu	37	6	31324917	31324917	+	Nonsense_Mutation	SNP	G	G	A	rs41553720		TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr6:31324917G>A	ENST00000412585.2	-	1	47	c.19C>T	c.(19-21)Cga>Tga	p.R7*		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B											endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						AGGACGGTTCGGGGCGCCATG	0.682000									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				7	30					0	0	1	0	0
OLFM1	10439	broad.mit.edu	37	9	137998599	137998599	+	Silent	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr9:137998599C>T	ENST00000252854.4	+	5	814	c.627C>T	c.(625-627)tgC>tgT	p.C209C	OLFM1_ENST00000371796.3_Silent_p.C200C|OLFM1_ENST00000371793.3_Silent_p.C227C	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	227					nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		TTCCAGCTTGCGGGAAGTTGA	0.647000													7	23					0	0	1	0	0
ONECUT1	3175	broad.mit.edu	37	15	53049960	53049960	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr15:53049960C>T	ENST00000305901.5	-	2	1317	c.1190G>A	c.(1189-1191)cGt>cAt	p.R397H	ONECUT1_ENST00000561401.2_5'UTR|ONECUT1_ENST00000560699.2_Missense_Mutation_p.V38I	NM_004498.2	NP_004489.1	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	397					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	17				all cancers(107;0.0708)		TAGAGTTCGACGCTGGACATC	0.468000													25	193					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9027468	9027468	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr3:9027468G>T	ENST00000383836.3	-	22	3462	c.3035C>A	c.(3034-3036)cCc>cAc	p.P1012H	SRGAP3_ENST00000360413.3_Missense_Mutation_p.P988H	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	1012					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GGTGTGAAGGGGACTGGCGGG	0.672000			T	RAF1	pilocytic astrocytoma								14	67					7.81268e-19	9.39382e-19	1	1	0
LOC101928372	101928372	broad.mit.edu	37	1	160905975	160905975	+	RNA	DEL	T	T	-			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr1:160905975delT	ENST00000356006.3	+	0	629																											cttcttcttcttttttttttt	0.393													2	4	---	---	---	---					
AQP12B	653437	broad.mit.edu	37	2	241621800	241621800	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr2:241621800delC	ENST00000407834.3	-	1	517	c.455delG	c.(454-456)acfs	p.S153fs		NM_001102467.1	NP_001095937.1	A6NM10	AQ12B_HUMAN	aquaporin 12B	141						integral to membrane	transporter activity	p.S152fs*24(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|lung(8)|ovary(1)	13		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		CAGGGCCGAGCTGCAGCTCTG	0.697													11	5	---	---	---	---					
LINC00969	440993	broad.mit.edu	37	3	195400814	195400815	+	RNA	INS	-	-	TT			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr3:195400814_195400815insTT	ENST00000445430.1	+	0	1410_1411																											ACCTGGTTGTCTGGTCAGGCAT	0.574													7	61	---	---	---	---					
SUDS3P1	285647	broad.mit.edu	37	5	177398373	177398396	+	RNA	DEL	AGGACGAAGAGCTGGAGAGCGCCA	AGGACGAAGAGCTGGAGAGCGCCA	-	rs70994948		TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr5:177398373_177398396delAGGACGAAGAGCTGGAGAGCGCCA	ENST00000511650.1	+	0	145																											GTCCCCGGGGAGGACGAAGAGCTGGAGAGCGCCAAGGACGACGA	0.683													5	7	---	---	---	---					
PHKG1	5260	broad.mit.edu	37	7	62693665	62693666	+	RNA	INS	-	-	C			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr7:62693665_62693666insC	ENST00000451381.1	-	0	181																											GCGATCACCTGAAGGCCACGCG	0.653													5	3	---	---	---	---					
DIS3	22894	broad.mit.edu	37	13	73349380	73349382	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr13:73349380_73349382delTCT	ENST00000377767.4	-	6	1054_1056	c.954_956delAGA	c.(952-957)gat>ga	p.ED318del	DIS3_ENST00000377780.4_In_Frame_Del_p.ED288del|DIS3_ENST00000545453.1_In_Frame_Del_p.ED156del	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	318					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TTTCTCCACATCTTCTTCATTTT	0.394										Multiple Myeloma(4;0.011)			27	91	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20086237	20086237	+	RNA	DEL	T	T	-			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr14:20086237delT	ENST00000548261.1	+	0	51																											GGTGTGTGTGTGGGGGGGTAT	0.388													5	5	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23299147	23299147	+	RNA	DEL	A	A	-			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr15:23299147delA	ENST00000560464.1	-	0	4510																											ACATTCAAAGAAAAAAAAAAA	0.313													2	4	---	---	---	---					
CASC5	57082	broad.mit.edu	37	15	40915815	40915816	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr15:40915815_40915816delTG	ENST00000346991.5	+	11	3821_3822	c.3431_3432delTG	c.(3430-3432)tfs	p.L1144fs	CASC5_ENST00000399668.2_Frame_Shift_Del_p.L1118fs			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	1144	2 X 104 AA approximate repeats.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		AAAACTATTTTGTATTCATGTG	0.426													15	75	---	---	---	---					
EDC4	23644	broad.mit.edu	37	16	67913767	67913769	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr16:67913767_67913769delCAG	ENST00000358933.5	+	16	2075_2077	c.1836_1838delCAG	c.(1834-1839)ccc>cc	p.PS612del		NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	612	Ser-rich.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CTGCCTCTCCcagcagcagcagc	0.611													8	158	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74394379	74394380	+	RNA	INS	-	-	A	rs142790741	by1000genomes	TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr16:74394379_74394380insA	ENST00000429810.2	-	0	435																											TAGTCATCCTTAAACAAAATTC	0.347													3	3	---	---	---	---					
CST5	1473	broad.mit.edu	37	20	23858182	23858182	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr20:23858182delA	ENST00000304710.4	-	2	378	c.305delT	c.(304-306)tgfs	p.L102fs		NM_001900.4	NP_001891.2	P28325	CYTD_HUMAN	cystatin D	102						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|stomach(1)	11						ACAGTTGTCCAAGTTGGGCTG	0.527													16	112	---	---	---	---					
MYH9	4627	broad.mit.edu	37	22	36689510	36689512	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chr22:36689510_36689512delCTC	ENST00000216181.5	-	30	4188_4190	c.3958_3960delGAG	c.(3958-3960)del	p.E1320del		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1320					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity	p.E1320D(1)		NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						TCTGCCGGTTCTCCTCCTGCAGC	0.616			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				24	144	---	---	---	---					
SRPX	8406	broad.mit.edu	37	X	38079976	38079978	+	In_Frame_Del	DEL	GCA	GCA	-	rs72445954		TCGA-F7-A620-01A-11D-A28R-08	TCGA-F7-A620-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c01fa25-4571-434e-a777-544e9fc9f607	cadcaafa-e9bc-429e-bf94-8fa6a43af319	g.chrX:38079976_38079978delGCA	ENST00000378533.3	-	1	174_176	c.68_70delTGC	c.(67-72)cgc>c	p.LR23del	SRPX_ENST00000432886.2_In_Frame_Del_p.LR23del|SRPX_ENST00000343800.6_Intron|TM4SF2_ENST00000465127.1_Intron|SRPX_ENST00000544439.1_In_Frame_Del_p.LR23del|SRPX_ENST00000538295.1_In_Frame_Del_p.LR23del	NM_006307.4	NP_006298.1	P78539	SRPX_HUMAN	sushi-repeat containing protein, X-linked	23			Missing.		cell adhesion	cell surface|membrane		p.L23delL(2)		autonomic_ganglia(1)|breast(2)|endometrium(5)|large_intestine(5)|lung(10)|prostate(2)	25						GGCGGGACGCgcagcagcagcag	0.729											OREG0019726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	7	---	---	---	---					
