Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MTERFD2	130916	broad.mit.edu	37	2	242038854	242038854	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:242038854C>G	ENST00000391980.2	-	2	535	c.477G>C	c.(475-477)atG>atC	p.M159I	MTERFD2_ENST00000495694.1_Missense_Mutation_p.M159I|MTERFD2_ENST00000407095.3_Missense_Mutation_p.M159I|MTERFD2_ENST00000406593.1_Intron	NM_182501.3	NP_872307.2	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	159										endometrium(3)|large_intestine(6)|lung(5)|ovary(1)|skin(2)|urinary_tract(3)	20		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		AGCGCTTCCTCATTTGCATAA	0.458000													19	77					0	0	1	0	0
KRT14	3861	broad.mit.edu	37	17	39739591	39739591	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:39739591C>T	ENST00000167586.6	-	6	1256	c.1170G>A	c.(1168-1170)gaG>gaA	p.E390E		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	390	Coil 2.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				GCTGCTCCATCTCGCAGCGGA	0.637000													15	69					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102114	22102114	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:22102114C>T	ENST00000542433.1	-	1	982	c.885G>A	c.(883-885)ctG>ctA	p.L295L		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		CCTGGTTCCTCAGTGTATAGA	0.478000													6	82					0	0	1	0	0
MTERFD2	130916	broad.mit.edu	37	2	242038896	242038896	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:242038896C>G	ENST00000391980.2	-	2	493	c.435G>C	c.(433-435)ttG>ttC	p.L145F	MTERFD2_ENST00000495694.1_Missense_Mutation_p.L145F|MTERFD2_ENST00000407095.3_Missense_Mutation_p.L145F|MTERFD2_ENST00000406593.1_Intron	NM_182501.3	NP_872307.2	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	145										endometrium(3)|large_intestine(6)|lung(5)|ovary(1)|skin(2)|urinary_tract(3)	20		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		GACTTTTCTTCAAGACCACAC	0.463000													19	82					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	48936983	48936983	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr13:48936983C>T	ENST00000267163.4	+	8	889	c.751C>T	c.(751-753)Cga>Tga	p.R251*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	251					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(6)|p.R251*(5)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGGTTCACCTCGAACACCCAG	0.343000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			19	36					0	0	1	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171766223	171766223	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr5:171766223G>A	ENST00000311601.5	-	13	2056	c.1886C>T	c.(1885-1887)gCc>gTc	p.A629V	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	629					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTGGGGAGTGGCATCTGGCTT	0.567000													4	109					0	0	1	0	0
B3GNT8	374907	broad.mit.edu	37	19	41931603	41931603	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:41931603C>T	ENST00000321702.2	-	3	1534	c.1081G>A	c.(1081-1083)Gac>Aac	p.D361N	CTC-435M10.6_ENST00000598887.1_RNA	NM_198540.2	NP_940942.1	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	361					poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity			cervix(1)|kidney(2)|large_intestine(1)|lung(5)|prostate(2)	11						GCAGTGCGGTCTGCTGGCCAG	0.657000													14	68					0	0	1	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298763	125298763	+	Missense_Mutation	SNP	A	A	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:125298763A>G	ENST00000538699.1	-	2	1225	c.1145T>C	c.(1144-1146)tTc>tCc	p.F382S	DCAF12L2_ENST00000360028.2_Missense_Mutation_p.F382S	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	382										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						CTCCTCCAGGAACTTCTGGGC	0.632000													5	140					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	62989911	62989911	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr15:62989911C>T	ENST00000561311.1	+	14	1547	c.1317C>T	c.(1315-1317)ttC>ttT	p.F439F	TLN2_ENST00000306829.6_Silent_p.F439F			Q9Y4G6	TLN2_HUMAN	talin 2	439					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						AGCAGCAGTTCAACCGGACCG	0.617000													6	178					0	0	1	0	0
SOCS6	9306	broad.mit.edu	37	18	67993164	67993164	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr18:67993164G>A	ENST00000397942.3	+	2	1576	c.1260G>A	c.(1258-1260)ttG>ttA	p.L420L	SOCS6_ENST00000582322.1_Silent_p.L420L	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	420	SH2.				defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				TTTTAAGCTTGAGCTTTCGCT	0.463000													17	71					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16347835	16347835	+	Nonsense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr20:16347835G>A	ENST00000408042.1	-	23	4292	c.4135C>T	c.(4135-4137)Caa>Taa	p.Q1379*	KIF16B_ENST00000378003.2_Intron|KIF16B_ENST00000354981.2_Intron|KIF16B_ENST00000355755.3_Intron	NM_001199866.1	NP_001186795.1	Q96L93	KI16B_HUMAN	kinesin family member 16B	0					cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						GCCTCATCTTGAGAATTGAAA	0.408000													7	39					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53358331	53358331	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr16:53358331G>A	ENST00000566029.1	+	39	8379	c.8170G>A	c.(8170-8172)Gaa>Aaa	p.E2724K	CHD9_ENST00000564845.1_Missense_Mutation_p.E2724K|CHD9_ENST00000447540.1_Missense_Mutation_p.E2725K|CHD9_ENST00000398510.3_Missense_Mutation_p.E2740K			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2740					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				ATCTGGGACAGAAGACAAAAA	0.478000													15	42					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72338069	72338069	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:72338069C>T	ENST00000389916.4	+	3	313	c.175C>T	c.(175-177)Cgc>Tgc	p.R59C		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	59	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						GCGGGCGCATCGCTCCCGGGA	0.667000													25	165					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95088735	95088735	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:95088735C>T	ENST00000553947.1	+	7	1938	c.1050C>T	c.(1048-1050)aaC>aaT	p.N350N	SERPINA3_ENST00000467132.1_Silent_p.N325N|SERPINA3_ENST00000393078.3_Silent_p.N325N|SERPINA3_ENST00000393080.4_Silent_p.N325N|SERPINA3_ENST00000556388.1_3'UTR|SERPINA3_ENST00000482740.1_Silent_p.N107N			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	325					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		ATAACCTGAACGACATACTTC	0.498000													7	69					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21461945	21461945	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr18:21461945G>A	ENST00000313654.9	+	40	5399	c.5158G>A	c.(5158-5160)Gag>Aag	p.E1720K	LAMA3_ENST00000399516.3_Missense_Mutation_p.E1720K|LAMA3_ENST00000587184.1_Missense_Mutation_p.E111K|LAMA3_ENST00000269217.6_Missense_Mutation_p.E111K	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1720	Domain III A.|Laminin EGF-like 13.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACGCTGCCAGGAGGGCTACTA	0.572000													15	53					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5395094	5395094	+	Missense_Mutation	SNP	G	G	A	rs147930423		TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr18:5395094G>A	ENST00000341928.2	-	21	3465	c.3125C>T	c.(3124-3126)aCg>aTg	p.T1042M	EPB41L3_ENST00000427684.2_Missense_Mutation_p.T339M|EPB41L3_ENST00000544123.1_Missense_Mutation_p.T873M|EPB41L3_ENST00000540638.2_Missense_Mutation_p.T820M|EPB41L3_ENST00000400111.3_Missense_Mutation_p.T820M|EPB41L3_ENST00000342933.3_Missense_Mutation_p.T1042M|EPB41L3_ENST00000542146.1_Missense_Mutation_p.T347M|EPB41L3_ENST00000542652.2_5'UTR	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	1042	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						TGCATCCCCCGTGATGACTAT	0.448000													5	86					0	0	1	0	0
UBE2E2	7325	broad.mit.edu	37	3	23574161	23574161	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:23574161C>T	ENST00000396703.1	+	5	657	c.477C>T	c.(475-477)tcC>tcT	p.S159S	UBE2E2_ENST00000425792.1_Silent_p.S159S	NM_152653.3	NP_689866.1	Q96LR5	UB2E2_HUMAN	ubiquitin-conjugating enzyme E2E 2	159					ISG15-protein conjugation|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination	nucleolus	ATP binding|ISG15 ligase activity|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(2)	10						TTCTCCTCTCCATCTGCTCAC	0.388000													17	37					0	0	1	0	0
MEOX1	4222	broad.mit.edu	37	17	41738457	41738457	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:41738457G>C	ENST00000318579.4	-	1	865	c.446C>G	c.(445-447)tCc>tGc	p.S149C	MEOX1_ENST00000549132.1_Missense_Mutation_p.P120A|MEOX1_ENST00000393661.2_Missense_Mutation_p.S34C|MEOX1_ENST00000329168.3_Missense_Mutation_p.S149C	NM_001040002.1|NM_004527.3	NP_001035091.1|NP_004518.1	P50221	MEOX1_HUMAN	mesenchyme homeobox 1	149						nucleus	sequence-specific DNA binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	8		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0753)		TCTCCGCCTGGATGATTTCTT	0.577000													10	269					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584883	82584883	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:82584883C>G	ENST00000423517.2	-	5	5723	c.5386G>C	c.(5386-5388)Gaa>Caa	p.E1796Q	PCLO_ENST00000333891.8_Missense_Mutation_p.E1796Q	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1727					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGTTGCTGTTCTATTTCCCTC	0.383000													28	56					0	0	1	0	0
PRDM4	11108	broad.mit.edu	37	12	108128117	108128117	+	Nonsense_Mutation	SNP	G	G	T	rs148191921		TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:108128117G>T	ENST00000228437.5	-	12	2735	c.2276C>A	c.(2275-2277)tCg>tAg	p.S759*		NM_012406.3	NP_036538.3	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	759					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(2)|skin(2)|urinary_tract(1)	20						TGGTGCTGACGAACTGGAGGT	0.473000													21	93					2.54575e-18	2.73698e-18	1	1	0
MTPN	136319	broad.mit.edu	37	7	135635385	135635385	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:135635385C>T	ENST00000393085.3	-	3	447	c.232G>A	c.(232-234)Gag>Aag	p.E78K	MTPN_ENST00000435723.1_Intron	NM_001128619.2|NM_145808.3	NP_001122091.2|NP_665807.1	P58546	MTPN_HUMAN	myotrophin	78					cell growth|regulation of striated muscle tissue development|regulation of translation	cytoplasm	protein binding			endometrium(1)|lung(4)|prostate(1)	6						ACATGACCCTCATAGACAGCA	0.338000													6	104					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7796794	7796794	+	Missense_Mutation	SNP	A	A	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:7796794A>C	ENST00000380358.4	+	5	878	c.877A>C	c.(877-879)Ata>Cta	p.I293L	CHD3_ENST00000358181.4_Missense_Mutation_p.I234L|CHD3_ENST00000330494.7_Missense_Mutation_p.I234L	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	234					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				GGCCACCCCCATAGCACCCTC	0.657000													3	13					0	0	1	0	0
SERBP1	26135	broad.mit.edu	37	1	67885715	67885715	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:67885715G>C	ENST00000370994.4	-	6	1024	c.910C>G	c.(910-912)Ctt>Gtt	p.L304V	SERBP1_ENST00000370990.5_Missense_Mutation_p.L319V|SERBP1_ENST00000484880.1_5'UTR|SERBP1_ENST00000361219.6_Missense_Mutation_p.L310V|SERBP1_ENST00000370995.2_Missense_Mutation_p.L325V	NM_001018067.1|NM_001018068.1|NM_001018069.1|NM_015640.3	NP_001018077.1|NP_001018078.1|NP_001018079.1|NP_056455.3	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1	325					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	13						GATTTATGAAGAACAAATCCC	0.323000													8	49					0	0	1	0	0
EFHC1	114327	broad.mit.edu	37	6	52355018	52355018	+	Nonsense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:52355018C>G	ENST00000371068.5	+	10	1824	c.1721C>G	c.(1720-1722)tCa>tGa	p.S574*	EFHC1_ENST00000433625.2_Nonsense_Mutation_p.S483*|EFHC1_ENST00000538167.1_Nonsense_Mutation_p.S555*	NM_018100.3	NP_060570.2	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	574	EF-hand.					axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	27	Lung NSC(77;0.109)					AAAGATCACTCATGCAAAGAC	0.393000													6	58					0	0	1	0	0
CKAP2L	150468	broad.mit.edu	37	2	113514069	113514069	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:113514069C>G	ENST00000541405.1	-	4	907	c.384G>C	c.(382-384)aaG>aaC	p.K128N	CKAP2L_ENST00000302450.6_Missense_Mutation_p.K293N			Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	293						centrosome		p.K293N(1)		breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	28						CTACTGGTTTCTTTGATGACT	0.398000													17	42					0	0	1	0	0
EEA1	8411	broad.mit.edu	37	12	93226487	93226487	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:93226487C>G	ENST00000322349.8	-	11	1319	c.1055G>C	c.(1054-1056)aGa>aCa	p.R352T		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	352					early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						TGCAGACAATCTTGACTGAAG	0.363000													5	52					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16255380	16255380	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:16255380G>C	ENST00000375759.3	+	11	2849	c.2645G>C	c.(2644-2646)cGa>cCa	p.R882P		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	882					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GTTTTGACTCGAGTGAAAGAG	0.463000													4	175					0	0	1	0	0
C3orf33	285315	broad.mit.edu	37	3	155485381	155485381	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:155485381C>G	ENST00000534941.1	-	5	540	c.271G>C	c.(271-273)Gag>Cag	p.E91Q	C3orf33_ENST00000340171.2_Missense_Mutation_p.E134Q	NM_173657.1	NP_775928.1	Q96NB5	Q96NB5_HUMAN	chromosome 3 open reading frame 33	91							hydrolase activity, acting on ester bonds|nucleic acid binding			breast(1)|kidney(1)|large_intestine(3)|lung(3)	8			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GGTTTTAGCTCTTTTTGTAAC	0.418000													5	20					0	0	1	0	0
MAS1	4142	broad.mit.edu	37	6	160328944	160328944	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:160328944C>T	ENST00000252660.4	+	1	971	c.957C>T	c.(955-957)gtC>gtT	p.V319V		NM_002377.2	NP_002368.1	P04201	MAS_HUMAN	MAS1 oncogene	319					anatomical structure morphogenesis|cell proliferation|protein kinase C signaling cascade	integral to plasma membrane	angiotensin type II receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.6e-06)		GTAATACGGTCACAGTTGAGA	0.403000													11	43					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61511322	61511322	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr20:61511322C>T	ENST00000266070.4	-	16	6311	c.5986G>A	c.(5986-5988)Gca>Aca	p.A1996T	DIDO1_ENST00000395343.1_Missense_Mutation_p.A1996T	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1996	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GAAAAGGGTGCGGACCCCCGT	0.597000													4	144					0	0	1	0	0
MTERFD2	130916	broad.mit.edu	37	2	242038875	242038875	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:242038875C>T	ENST00000391980.2	-	2	514	c.456G>A	c.(454-456)ttG>ttA	p.L152L	MTERFD2_ENST00000495694.1_Silent_p.L152L|MTERFD2_ENST00000407095.3_Silent_p.L152L|MTERFD2_ENST00000406593.1_Intron	NM_182501.3	NP_872307.2	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	152										endometrium(3)|large_intestine(6)|lung(5)|ovary(1)|skin(2)|urinary_tract(3)	20		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		TAGGCAGTTTCAATAACTGGG	0.463000													22	78					0	0	1	0	0
KCNQ4	9132	broad.mit.edu	37	1	41285102	41285102	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:41285102C>G	ENST00000347132.5	+	5	874	c.792C>G	c.(790-792)aaC>aaG	p.N264K	KCNQ4_ENST00000506017.1_3'UTR|KCNQ4_ENST00000509682.2_Missense_Mutation_p.N264K	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	264					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			AGGACGCCAACTCCGACTTCT	0.637000													26	97					0	0	1	0	0
RTKN	6242	broad.mit.edu	37	2	74653396	74653396	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:74653396G>A	ENST00000305557.5	-	13	2212	c.1627C>T	c.(1627-1629)Cgc>Tgc	p.R543C	RTKN_ENST00000233330.6_Missense_Mutation_p.R506C|RTKN_ENST00000272430.5_Missense_Mutation_p.R556C	NM_033046.2	NP_149035.1	Q9BST9	RTKN_HUMAN	rhotekin	556	Pro-rich.				apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			endometrium(3)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	16						AGCCAAGTGCGAGGTTGGCCT	0.622000													42	145					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14278223	14278223	+	RNA	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:14278223G>A	ENST00000310358.7	+	0	1829							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		CCTGGCTCCAGAAGAGAAAGA	0.393000													14	47					0	0	1	0	0
MIR1207	100302175	broad.mit.edu	37	8	129061434	129061434	+	RNA	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr8:129061434G>A	ENST00000408249.1	+	0	37					NR_031612.1																						GGCTGGCTGGGTCTGGTAGTG	0.567000													22	56					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68153966	68153966	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:68153966G>A	ENST00000294304.7	+	6	1304	c.1198G>A	c.(1198-1200)Gcg>Acg	p.A400T		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	400	Beta-propeller 2.		A -> E (in OPPG).		adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CATCCGCAGGGCGTACCTGGA	0.642000													17	61					0	0	1	0	0
TRIM21	6737	broad.mit.edu	37	11	4407008	4407008	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:4407008C>G	ENST00000254436.7	-	7	1047	c.935G>C	c.(934-936)gGa>gCa	p.G312A	TRIM21_ENST00000543625.1_Missense_Mutation_p.G312A	NM_003141.3	NP_003132.2	P19474	RO52_HUMAN	tripartite motif containing 21	312	B30.2/SPRY.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)	16		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		CTGGGTGTCTCCAAGCCTCAC	0.502000													3	12					0	0	1	0	0
IL17D	53342	broad.mit.edu	37	13	21295937	21295937	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr13:21295937C>T	ENST00000304920.3	+	3	561	c.453C>T	c.(451-453)ggC>ggT	p.G151G		NM_138284.1	NP_612141.1	Q8TAD2	IL17D_HUMAN	interleukin 17D	151					inflammatory response	extracellular space	cytokine activity			endometrium(1)|skin(1)	2		all_cancers(29;9.63e-24)|all_epithelial(30;1.09e-19)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000301)|Epithelial(112;0.000633)|OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Lung(94;0.0154)|LUSC - Lung squamous cell carcinoma(192;0.0414)		CCTGCGCCGGCGGCCGTTCCG	0.706000													19	113					0	0	1	0	0
HMGXB4	10042	broad.mit.edu	37	22	35684398	35684398	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr22:35684398G>C	ENST00000216106.5	+	9	1764	c.1636G>C	c.(1636-1638)Gag>Cag	p.E546Q	HMGXB4_ENST00000444518.2_Missense_Mutation_p.E437Q	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	546					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GCAGGAAACTGAGGTGAATAC	0.438000													8	30					0	0	1	0	0
DPH3	285381	broad.mit.edu	37	3	16305733	16305733	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:16305733C>T	ENST00000488423.1	-	2	207	c.112G>A	c.(112-114)Gat>Aat	p.D38N	DPH3_ENST00000383775.4_Intron|DPH3_ENST00000285082.4_5'UTR	NM_206831.2	NP_996662.1	Q96FX2	DPH3_HUMAN	diphthamide biosynthesis 3	38					negative regulation of protein secretion|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|positive regulation of binding	cytoplasm|nucleus	metal ion binding|protein binding			large_intestine(2)	2						TTCTCCAAATCTTCCTACAAC	0.448000													4	17					0	0	1	0	0
ARID4A	5926	broad.mit.edu	37	14	58790207	58790207	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:58790207G>A	ENST00000355431.3	+	8	827	c.454G>A	c.(454-456)Gaa>Aaa	p.E152K	ARID4A_ENST00000395168.3_Missense_Mutation_p.E152K|ARID4A_ENST00000348476.3_Missense_Mutation_p.E152K|ARID4A_ENST00000431317.2_Missense_Mutation_p.E152K	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	152					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TTTTAGTACTGAAGATGAAAA	0.328000													11	33					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1488598	1488598	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:1488598C>T	ENST00000345913.4	+	9	1660	c.1569C>T	c.(1567-1569)ttC>ttT	p.F523F	TPO_ENST00000382198.1_Silent_p.F350F|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000346956.3_Silent_p.F523F|TPO_ENST00000329066.4_Silent_p.F523F|TPO_ENST00000349624.3_Silent_p.F350F|TPO_ENST00000337415.3_Silent_p.F523F|TPO_ENST00000382201.3_Silent_p.F523F	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	523					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	ACCAGGCTTTCTTCAGCCCAT	0.562000													12	81					0	0	1	0	0
FIG4	9896	broad.mit.edu	37	6	110113840	110113840	+	Nonsense_Mutation	SNP	C	C	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:110113840C>A	ENST00000230124.3	+	21	2556	c.2432C>A	c.(2431-2433)tCa>tAa	p.S811*	FIG4_ENST00000441478.2_Nonsense_Mutation_p.S534*	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	811					cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		GATGGCCTCTCAGAAGAAGAT	0.318000													10	69					9.70103e-10	1.01905e-09	1	1	0
AFF1	4299	broad.mit.edu	37	4	87967403	87967403	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr4:87967403C>T	ENST00000307808.6	+	2	523	c.103C>T	c.(103-105)Cct>Tct	p.P35S	AFF1_ENST00000395146.4_Missense_Mutation_p.P42S|AFF1_ENST00000544085.1_Intron	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	35						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		AGAGGCATTTCCTGAAAAGAT	0.418000													30	121					0	0	1	0	0
SLC25A19	60386	broad.mit.edu	37	17	73273537	73273537	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:73273537C>T	ENST00000402418.3	-	5	1580	c.671G>A	c.(670-672)aGt>aAt	p.S224N	SLC25A19_ENST00000320362.3_Missense_Mutation_p.S224N|SLC25A19_ENST00000416858.2_Missense_Mutation_p.S224N|SLC25A19_ENST00000375261.4_Missense_Mutation_p.S167N|SLC25A19_ENST00000442286.2_Missense_Mutation_p.S224N|SLC25A19_ENST00000580994.1_Missense_Mutation_p.S224N			Q9HC21	TPC_HUMAN	solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19	224						integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			ACCAGCTCCACTGCCACAAAG	0.517000													22	48					0	0	1	0	0
SPTY2D1	144108	broad.mit.edu	37	11	18637573	18637573	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:18637573C>T	ENST00000336349.5	-	3	483	c.248G>A	c.(247-249)aGa>aAa	p.R83K	SPTY2D1_ENST00000543776.1_5'UTR	NM_194285.2	NP_919261.2	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)	83										breast(4)|cervix(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|skin(1)|stomach(1)	30						GGCCATAGCTCTTGCTTTCTT	0.403000													6	61					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37534656	37534656	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr20:37534656C>T	ENST00000299824.1	+	7	930	c.741C>T	c.(739-741)ctC>ctT	p.L247L	PPP1R16B_ENST00000373331.2_Intron	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	247					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				CAGCTGAGCTCCTCCTGGACC	0.597000													25	41					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42373213	42373213	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr15:42373213C>T	ENST00000290472.3	-	12	1170	c.1076G>A	c.(1075-1077)gGc>gAc	p.G359D		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	359	PLA2c.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		GCCAGAGATGCCACTGAAGTA	0.607000													11	33					0	0	1	0	0
ZNF416	55659	broad.mit.edu	37	19	58084885	58084885	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:58084885C>G	ENST00000196489.3	-	4	609	c.387G>C	c.(385-387)ttG>ttC	p.L129F		NM_017879.1	NP_060349.1	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(5)|lung(12)|prostate(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		ATGCCCCAGTCAAGTATAGTT	0.517000													3	28					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222802495	222802495	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:222802495G>A	ENST00000344922.5	+	4	1958	c.1933G>A	c.(1933-1935)Gaa>Aaa	p.E645K	MIA3_ENST00000344507.1_Intron|MIA3_ENST00000470521.1_3'UTR|MIA3_ENST00000344441.6_Missense_Mutation_p.E645K	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	645					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		CAGAGAACTGGAAGACGAGGT	0.448000													7	116					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27730604	27730604	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:27730604C>T	ENST00000264717.2	+	14	1263	c.1200C>T	c.(1198-1200)ctC>ctT	p.L400L	GCKR_ENST00000424318.2_Silent_p.L210L	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	400	SIS 2.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					TTCCCTCTCTCACGGAAATCG	0.547000													10	50					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160143991	160143991	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:160143991C>T	ENST00000368081.4	+	14	2553	c.2082C>T	c.(2080-2082)atC>atT	p.I694I	ATP1A4_ENST00000418334.1_3'UTR	NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	694					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			accctgagatcgtgtttgctc	0.527000													24	39					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1246017	1246017	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr16:1246017G>A	ENST00000348261.5	+	5	885	c.637G>A	c.(637-639)Gtg>Atg	p.V213M	CACNA1H_ENST00000358590.4_Missense_Mutation_p.V213M|CACNA1H_ENST00000565831.1_Missense_Mutation_p.V213M	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	213					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CATCAACCGCGTGCCTAGTAA	0.652000													25	47					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94544910	94544910	+	Missense_Mutation	SNP	C	C	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:94544910C>A	ENST00000370225.3	-	9	1293	c.1207G>T	c.(1207-1209)Gat>Tat	p.D403Y	ABCA4_ENST00000535735.1_Missense_Mutation_p.D403Y	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	403					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GCAGGTGAATCAGGAGTGTAC	0.493000													25	63					7.07758e-08	7.36712e-08	1	1	0
PRG4	10216	broad.mit.edu	37	1	186276382	186276382	+	Missense_Mutation	SNP	A	A	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:186276382A>C	ENST00000445192.2	+	7	1576	c.1531A>C	c.(1531-1533)Acc>Ccc	p.T511P	PRG4_ENST00000367483.4_Missense_Mutation_p.T470P|PRG4_ENST00000367485.4_Missense_Mutation_p.T418P|PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367486.3_Missense_Mutation_p.T468P	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	511	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						ACCCACCACCACCAAGGAGCC	0.637000													12	179					0	0	1	0	0
GPATCH3	63906	broad.mit.edu	37	1	27224089	27224089	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:27224089C>T	ENST00000361720.5	-	2	602	c.579G>A	c.(577-579)ggG>ggA	p.G193G		NM_022078.2	NP_071361.2	Q96I76	GPTC3_HUMAN	G patch domain containing 3	193						intracellular	nucleic acid binding			endometrium(2)|large_intestine(1)|lung(11)|skin(1)	15		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		TCCCCACATTCCCTCTGGGCA	0.602000													12	50					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16258490	16258490	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:16258490C>T	ENST00000375759.3	+	11	5959	c.5755C>T	c.(5755-5757)Cct>Tct	p.P1919S		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1919					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AAACCGCTCTCCTGTCAAAGA	0.562000													4	115					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177084360	177084360	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr4:177084360G>C	ENST00000393643.2	+	22	3158	c.2906G>C	c.(2905-2907)gGc>gCc	p.G969A	WDR17_ENST00000508596.1_Missense_Mutation_p.G969A|WDR17_ENST00000280190.4_Missense_Mutation_p.G993A|WDR17_ENST00000507824.2_Missense_Mutation_p.G976A	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	993										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		GTCTGTGTGGGCACAGTACTA	0.433000													15	45					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107555499	107555499	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr9:107555499G>C	ENST00000374736.3	-	41	5983	c.5589C>G	c.(5587-5589)ttC>ttG	p.F1863L		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	1863					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TAATGAGGAAGAACACCACCC	0.517000													7	104					0	0	1	0	0
MED29	55588	broad.mit.edu	37	19	39883109	39883109	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:39883109G>C	ENST00000315588.5	+	2	334	c.285G>C	c.(283-285)ttG>ttC	p.L95F	MED29_ENST00000599213.2_Missense_Mutation_p.L74F|MED29_ENST00000594368.1_Missense_Mutation_p.L74F	NM_017592.1	NP_060062.1	Q9NX70	MED29_HUMAN	mediator complex subunit 29	74					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	protein binding			lung(2)|ovary(1)|pancreas(1)	4	all_cancers(60;7.82e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;1.04e-26)|all cancers(26;7.68e-24)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			ACTAGACCTTGATGAAGGTTG	0.433000													6	32					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11500389	11500389	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:11500389C>T	ENST00000423059.3	-	11	2756	c.2505G>A	c.(2503-2505)tgG>tgA	p.W835*	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	835						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TGTGAGTCTTCCACCTACAAG	0.532000										HNSCC(18;0.044)			5	13					0	0	1	0	0
PHLDA1	22822	broad.mit.edu	37	12	76424831	76424831	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:76424831C>T	ENST00000266671.5	-	1	2881	c.691G>A	c.(691-693)Gaa>Aaa	p.E231K	RP11-290L1.3_ENST00000552367.1_RNA|PHLDA1_ENST00000602540.1_Missense_Mutation_p.E90K			Q8WV24	PHLA1_HUMAN	pleckstrin homology-like domain, family A, member 1	231	PH.				apoptosis	cytoplasmic vesicle membrane|nucleolus|plasma membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	14		Colorectal(145;0.09)				AAGTGCAGTTCCTTGAGCTTG	0.627000													7	79					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141497652	141497652	+	Missense_Mutation	SNP	C	C	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:141497652C>A	ENST00000264952.2	+	1	663	c.526C>A	c.(526-528)Ctg>Atg	p.L176M		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	176	RGS.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CGACAAGTTTCTGCAGTGGAA	0.532000													14	85					6.31663e-08	6.60506e-08	1	1	0
SYNJ2BP	55333	broad.mit.edu	37	14	70855193	70855193	+	Silent	SNP	G	G	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:70855193G>T	ENST00000256366.4	-	2	276	c.195C>A	c.(193-195)atC>atA	p.I65I	SYNJ2BP_ENST00000554216.1_Intron|RP11-718G2.3_ENST00000555276.1_RNA	NM_018373.2	NP_060843.2			synaptojanin 2 binding protein											central_nervous_system(1)|kidney(2)|large_intestine(1)|upper_aerodigestive_tract(1)	5				all cancers(60;0.00367)|BRCA - Breast invasive adenocarcinoma(234;0.00716)|OV - Ovarian serous cystadenocarcinoma(108;0.0377)		TCACCGAAAGGATCTTATCAC	0.542000													7	26					1.06961e-07	1.10833e-07	1	1	0
PKDREJ	10343	broad.mit.edu	37	22	46658489	46658489	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr22:46658489G>A	ENST00000253255.5	-	1	730	c.731C>T	c.(730-732)tCg>tTg	p.S244L		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	244	REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CAGCTGCACCGAGGCGTTGAT	0.697000													8	39					0	0	1	0	0
PRUNE	58497	broad.mit.edu	37	1	150997133	150997133	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:150997133C>G	ENST00000271620.3	+	4	538	c.382C>G	c.(382-384)Cga>Gga	p.R128G	PRUNE_ENST00000467771.1_3'UTR|PRUNE_ENST00000368937.1_Intron|PRUNE_ENST00000368936.1_5'UTR|PRUNE_ENST00000271619.8_Intron|PRUNE_ENST00000368935.1_Intron	NM_021222.1	NP_067045.1	Q86TP1	PRUNE_HUMAN	prune exopolyphosphatase	128						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	14	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCTAGACCATCGACCCATCGA	0.577000											OREG0013792	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	64					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93650884	93650884	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr9:93650884C>T	ENST00000375754.4	+	13	1958	c.1810C>T	c.(1810-1812)Ctc>Ttc	p.L604F	SYK_ENST00000375746.1_Missense_Mutation_p.L604F|SYK_ENST00000375747.1_Missense_Mutation_p.L581F|SYK_ENST00000375751.4_Missense_Mutation_p.L581F	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	604	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						GATGTACGATCTCATGAATCT	0.473000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								6	8					0	0	1	0	0
TMCC1	23023	broad.mit.edu	37	3	129389575	129389575	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:129389575C>T	ENST00000393238.3	-	4	1449	c.1109G>A	c.(1108-1110)aGa>aAa	p.R370K	TMCC1_ENST00000329333.5_Missense_Mutation_p.R191K|TMCC1_ENST00000426664.2_Missense_Mutation_p.R256K|TMCC1_ENST00000432054.2_Missense_Mutation_p.R46K	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	370						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						GGCAATCTCTCTGGGCTTTGA	0.527000													4	61					0	0	1	0	0
SOCS6	9306	broad.mit.edu	37	18	67991962	67991962	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr18:67991962G>C	ENST00000397942.3	+	2	374	c.58G>C	c.(58-60)Gaa>Caa	p.E20Q	SOCS6_ENST00000582322.1_Missense_Mutation_p.E20Q	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	20					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				TAAAAGTAAAGAAGAAACTGA	0.343000													7	53					0	0	1	0	0
HNRNPR	10236	broad.mit.edu	37	1	23645146	23645146	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:23645146C>T	ENST00000478691.1	-	7	824	c.553G>A	c.(553-555)Gat>Aat	p.D185N	HNRNPR_ENST00000374612.1_Missense_Mutation_p.D283N|HNRNPR_ENST00000374616.3_Missense_Mutation_p.D286N|HNRNPR_ENST00000427764.2_Missense_Mutation_p.D245N|HNRNPR_ENST00000302271.6_Missense_Mutation_p.D283N|HNRNPR_ENST00000426846.2_Missense_Mutation_p.D123N|HNRNPR_ENST00000606561.1_Missense_Mutation_p.D144N	NM_001102397.1|NM_001102399.1	NP_001095867.1|NP_001095869.1	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	283	RRM 1.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		TTTTTGTCATCGGGTTGATGA	0.453000													15	47					0	0	1	0	0
FOS	2353	broad.mit.edu	37	14	75748023	75748023	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:75748023G>A	ENST00000303562.4	+	4	1248	c.1039G>A	c.(1039-1041)Gag>Aag	p.E347K	FOS_ENST00000535987.1_Missense_Mutation_p.E311K|FOS_ENST00000555347.1_Missense_Mutation_p.E199K|FOS_ENST00000555686.1_Missense_Mutation_p.E233K	NM_005252.3	NP_005243.1	P01100	FOS_HUMAN	FBJ murine osteosarcoma viral oncogene homolog	347					cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		CACCTACCCCGAGGCTGACTC	0.642000													27	112					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76187031	76187031	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:76187031C>T	ENST00000298832.9	+	12	1232	c.1027C>T	c.(1027-1029)Cgc>Tgc	p.R343C	TTLL5_ENST00000557636.1_Missense_Mutation_p.R343C|TTLL5_ENST00000555422.1_Intron	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	343	TTL.				protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		TGTTCCTCATCGCAGCAGTTG	0.428000													34	110					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26493217	26493217	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:26493217G>A	ENST00000381340.3	-	56	8318	c.7902C>T	c.(7900-7902)ctC>ctT	p.L2634L	RP11-513G19.1_ENST00000535324.1_RNA	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	2634					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					CATTGCTAACGAGGGACATGG	0.478000													5	41					0	0	1	0	0
IMMT	10989	broad.mit.edu	37	2	86371871	86371871	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:86371871G>C	ENST00000410111.3	-	15	2184	c.1797C>G	c.(1795-1797)atC>atG	p.I599M	IMMT_ENST00000409051.2_Missense_Mutation_p.I552M|IMMT_ENST00000254636.5_Missense_Mutation_p.I500M|IMMT_ENST00000449247.2_Missense_Mutation_p.I588M|IMMT_ENST00000442664.2_Missense_Mutation_p.I598M	NM_001100169.1|NM_001100170.1|NM_006839.2	NP_001093639.1|NP_001093640.1|NP_006830.2	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial	599						integral to mitochondrial inner membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						AGTTGGCTTTGATGGCCTCAA	0.507000													5	77					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40704287	40704287	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:40704287G>A	ENST00000298910.7	+	31	4430	c.4372G>A	c.(4372-4374)Gat>Aat	p.D1458N		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1458	Roc.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GGATGTTTCTGATGAGAAGCA	0.478000													27	81					0	0	1	0	0
TRIM16L	147166	broad.mit.edu	37	17	18635351	18635351	+	Splice_Site	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:18635351G>C	ENST00000449552.2	+	6	1851		c.e6-1		TRIM16L_ENST00000572555.1_Splice_Site|TRIM16L_ENST00000395672.2_Splice_Site|TRIM16L_ENST00000571708.1_Splice_Site|TRIM16L_ENST00000395902.3_Splice_Site|TRIM16L_ENST00000395671.4_Splice_Site|TRIM16L_ENST00000414850.2_Intron			Q309B1	TR16L_HUMAN	tripartite motif containing 16-like							cytoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)	9						TGATTTTCTAGAGGAGTATGA	0.498000													11	45					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208224401	208224401	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:208224401G>C	ENST00000367033.3	-	17	3965	c.3208C>G	c.(3208-3210)Cag>Gag	p.Q1070E		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1070	IPT/TIG 3.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		CTTGGCTCCTGAATGACATCC	0.493000													14	71					0	0	1	0	0
SOCS6	9306	broad.mit.edu	37	18	67992019	67992019	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr18:67992019G>C	ENST00000397942.3	+	2	431	c.115G>C	c.(115-117)Gat>Cat	p.D39H	SOCS6_ENST00000582322.1_Missense_Mutation_p.D39H	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	39					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				CTTTGGAAAAGATGATTCCTT	0.373000													13	76					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584766	82584766	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:82584766C>G	ENST00000423517.2	-	5	5840	c.5503G>C	c.(5503-5505)Gat>Cat	p.D1835H	PCLO_ENST00000333891.8_Missense_Mutation_p.D1835H	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1766					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGAGATGCATCTTCAATGGGA	0.433000													53	125					0	0	1	0	0
TNFRSF25	8718	broad.mit.edu	37	1	6522208	6522208	+	Silent	SNP	G	G	A	rs34221914	byFrequency	TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:6522208G>A	ENST00000377782.3	-	9	865	c.798C>T	c.(796-798)agC>agT	p.S266S	TNFRSF25_ENST00000356876.3_Silent_p.S257S|TNFRSF25_ENST00000351748.3_Silent_p.S74S|TNFRSF25_ENST00000348333.3_Silent_p.S212S|TNFRSF25_ENST00000351959.5_Silent_p.S220S	NM_148965.1	NP_683866.1	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily, member 25	257					apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(4)|prostate(1)|stomach(1)	10	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		GGGTGTGGGCGCTGTCCAAGG	0.632000													4	145					0	0	1	0	0
KRT14	3861	broad.mit.edu	37	17	39740128	39740128	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:39740128C>T	ENST00000167586.6	-	4	897	c.811G>A	c.(811-813)Gag>Aag	p.E271K		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	271	Linker 12.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				GCGTCCATCTCCACATTGACA	0.577000													22	139					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47425031	47425031	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:47425031G>A	ENST00000404338.3	+	1	3099	c.3099G>A	c.(3097-3099)ctG>ctA	p.L1033L		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	1033					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										AGAGTAAACTGAACAACAAAG	0.433000													10	51					0	0	1	0	0
SLTM	79811	broad.mit.edu	37	15	59192011	59192011	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr15:59192011C>T	ENST00000380516.2	-	7	802	c.715G>A	c.(715-717)Gag>Aag	p.E239K	SLTM_ENST00000536328.1_Intron	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	239	Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TTGTCATCCTCAGCTTCTTTC	0.443000													13	56					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656466	40656466	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:40656466C>G	ENST00000406785.1	-	2	1144	c.955G>C	c.(955-957)Gat>Cat	p.D319H	SLC8A1_ENST00000542756.1_Missense_Mutation_p.D319H|SLC8A1_ENST00000542024.1_Missense_Mutation_p.D319H|SLC8A1_ENST00000408028.2_Missense_Mutation_p.D319H|SLC8A1_ENST00000405901.3_Missense_Mutation_p.D319H|SLC8A1_ENST00000405269.1_Missense_Mutation_p.D319H|SLC8A1_ENST00000403092.1_Missense_Mutation_p.D319H|SLC8A1_ENST00000402441.1_Missense_Mutation_p.D319H|SLC8A1_ENST00000332839.4_Missense_Mutation_p.D319H|SLC8A1_ENST00000406391.2_Missense_Mutation_p.D319H			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	319					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GCTTCTTCATCATCTTGGTCC	0.398000													7	130					0	0	1	0	0
PDE7A	5150	broad.mit.edu	37	8	66639126	66639126	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr8:66639126G>C	ENST00000401827.3	-	9	1347	c.904C>G	c.(904-906)Ctg>Gtg	p.L302V	PDE7A_ENST00000379419.4_Missense_Mutation_p.L276V|PDE7A_ENST00000396642.3_Missense_Mutation_p.L302V	NM_001242318.2	NP_001229247.1	Q13946	PDE7A_HUMAN	phosphodiesterase 7A	302	Catalytic (By similarity).					cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			large_intestine(5)|lung(3)|stomach(1)|urinary_tract(1)	10			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	TCTAATGGCAGATGTGAGAAT	0.348000													33	80					0	0	1	0	0
AGO4	192670	broad.mit.edu	37	1	36306771	36306771	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:36306771C>T	ENST00000373210.3	+	14	1975	c.1730C>T	c.(1729-1731)tCg>tTg	p.S577L		NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		AGCAGGCCCTCGGTGTTCCAG	0.473000													11	43					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77948830	77948830	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:77948830C>T	ENST00000393684.3	-	5	935	c.544G>A	c.(544-546)Gag>Aag	p.E182K	ISM2_ENST00000493585.1_Intron|ISM2_ENST00000429906.1_Missense_Mutation_p.E189K|ISM2_ENST00000412904.1_Missense_Mutation_p.E189K|ISM2_ENST00000342219.4_Missense_Mutation_p.E270K			Q6H9L7	ISM2_HUMAN	isthmin 2	270						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						tcgtcttcctccttttcctcc	0.552000													16	47					0	0	1	0	0
HMGXB4	10042	broad.mit.edu	37	22	35684359	35684359	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr22:35684359G>C	ENST00000216106.5	+	9	1725	c.1597G>C	c.(1597-1599)Gag>Cag	p.E533Q	HMGXB4_ENST00000444518.2_Missense_Mutation_p.E424Q	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	533					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GCTGTTGGGAGAGTCCCTAAG	0.493000													14	44					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	65022083	65022083	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr16:65022083C>G	ENST00000394156.3	-	7	1429	c.976G>C	c.(976-978)Gag>Cag	p.E326Q	CDH11_ENST00000566827.1_Missense_Mutation_p.E200Q|CDH11_ENST00000268603.4_Missense_Mutation_p.E326Q			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	326	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		ATCACCCCCTCCTGTGTTTCA	0.443000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			22	93					0	0	1	0	0
C7orf55-LUC7L2	100996928	broad.mit.edu	37	7	139106952	139106952	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:139106952G>A	ENST00000354926.4	+	10	1399	c.1045G>A	c.(1045-1047)Gac>Aac	p.D349N	C7orf55-LUC7L2_ENST00000541170.3_Missense_Mutation_p.D346N|C7orf55-LUC7L2_ENST00000482860.1_3'UTR|C7orf55-LUC7L2_ENST00000263545.6_Missense_Mutation_p.D348N|LUC7L2_ENST00000541515.3_Missense_Mutation_p.D415N	NM_016019.3	NP_057103.2																					AGCATCATGTGACAGAGACAG	0.408000													29	62					0	0	1	0	0
SNHG10	283596	broad.mit.edu	37	14	95999834	95999834	+	RNA	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:95999834C>T	ENST00000500370.2	-	0	766				SCARNA13_ENST00000516672.1_RNA|SNHG10_ENST00000553559.1_RNA|SNHG10_ENST00000555866.1_RNA|SNHG10_ENST00000554169.1_RNA																							CAGAAACTATCAGAGGAAAAT	0.483000													9	146					0	0	1	0	0
PPT2-EGFL8	100532746	broad.mit.edu	37	6	32122955	32122955	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:32122955C>T	ENST00000422437.1	+	3	523	c.332C>T	c.(331-333)tCg>tTg	p.S111L	PPT2_ENST00000324816.6_Missense_Mutation_p.S111L|PPT2_ENST00000361568.2_Missense_Mutation_p.S117L|PPT2_ENST00000493548.1_3'UTR|PPT2_ENST00000375143.2_Missense_Mutation_p.S111L|PPT2_ENST00000437001.2_Intron|PPT2-EGFL8_ENST00000453656.2_3'UTR|PPT2_ENST00000445576.2_Missense_Mutation_p.S111L|PPT2_ENST00000395523.1_Missense_Mutation_p.S111L|PPT2_ENST00000375137.2_Missense_Mutation_p.S111L																							ATCTGCTACTCGCAGGGTAGG	0.572000													12	36					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153077603	153077603	+	Splice_Site	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr5:153077603G>A	ENST00000285900.5	+	9	1477		c.e9-1		GRIA1_ENST00000518783.1_Splice_Site|GRIA1_ENST00000340592.5_Splice_Site|GRIA1_ENST00000521843.2_Splice_Site|GRIA1_ENST00000518142.1_Splice_Site|GRIA1_ENST00000448073.4_Splice_Site	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1						synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTCATTAACAGATTGGTTACT	0.507000													6	31					0	0	1	0	0
ISY1	57461	broad.mit.edu	37	3	128853674	128853674	+	Missense_Mutation	SNP	C	C	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:128853674C>A	ENST00000393292.3	-	8	603	c.542G>T	c.(541-543)cGt>cTt	p.R181L	ISY1_ENST00000393295.3_Splice_Site|ISY1_ENST00000471497.1_Intron|ISY1_ENST00000273541.8_Splice_Site|ISY1-RAB43_ENST00000418265.1_Splice_Site					ISY1 splicing factor homolog (S. cerevisiae)											endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|prostate(1)|skin(1)	15						CAGAGACCTACGTTTCTTTTC	0.388000													32	67					1.62565e-12	1.72349e-12	1	1	0
ADCY4	196883	broad.mit.edu	37	14	24789035	24789035	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:24789035G>A	ENST00000310677.4	-	22	2759	c.2646C>T	c.(2644-2646)ttC>ttT	p.F882F	ADCY4_ENST00000418030.2_Silent_p.F882F|ADCY4_ENST00000554068.2_Silent_p.F882F	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	882					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		AGAACTCCTTGAAGTCTGGGA	0.478000													7	50					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101648654	101648654	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr10:101648654C>T	ENST00000342239.3	-	12	3376	c.3285G>A	c.(3283-3285)gaG>gaA	p.E1095E	DNMBP_ENST00000543621.1_Silent_p.E317E|DNMBP_ENST00000472036.1_5'UTR|DNMBP_ENST00000540316.1_Silent_p.E7E|DNMBP_ENST00000324109.4_Silent_p.E1071E			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1071	BAR.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		GGTGTCCTCTCTCCATGCACA	0.498000													11	35					0	0	1	0	0
KRBA2	124751	broad.mit.edu	37	17	8272706	8272706	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:8272706C>G	ENST00000396267.1	-	2	1810	c.979G>C	c.(979-981)Gag>Cag	p.E327Q	KRBA2_ENST00000331336.2_Missense_Mutation_p.E409Q|RP11-849F2.7_ENST00000582471.1_3'UTR|RP11-849F2.5_ENST00000580537.1_RNA|RP11-849F2.5_ENST00000583963.1_RNA			Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	409	Integrase catalytic.				DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(5)|stomach(1)|urinary_tract(1)	18						AACATTGCCTCAAATGGACTT	0.468000													16	67					0	0	1	0	0
RAI2	10742	broad.mit.edu	37	X	17818621	17818621	+	Missense_Mutation	SNP	T	T	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:17818621T>G	ENST00000545871.1	-	3	1970	c.1510A>C	c.(1510-1512)Aag>Cag	p.K504Q	RAI2_ENST00000451717.1_Missense_Mutation_p.K504Q|RAI2_ENST00000415486.3_Missense_Mutation_p.K454Q|RAI2_ENST00000360011.1_Missense_Mutation_p.K504Q|RAI2_ENST00000331511.1_Missense_Mutation_p.K504Q	NM_001172739.1|NM_001172743.1	NP_001166210.1|NP_001166214.1	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	504					embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					TTCTTTAACTTTATGCTCCGG	0.438000													132	359					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67062613	67062613	+	Missense_Mutation	SNP	A	A	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr8:67062613A>T	ENST00000315962.4	+	7	1270	c.897A>T	c.(895-897)aaA>aaT	p.K299N	TRIM55_ENST00000276573.7_Missense_Mutation_p.K299N|TRIM55_ENST00000353317.5_Missense_Mutation_p.K299N|TRIM55_ENST00000350034.4_Intron	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	299	COS.					cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			AGATGGAGAAAATAGAACATG	0.378000													14	52					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2696680	2696680	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr4:2696680G>A	ENST00000324666.5	+	15	2578	c.2227G>A	c.(2227-2229)Gac>Aac	p.D743N	FAM193A_ENST00000505311.1_Missense_Mutation_p.D743N|FAM193A_ENST00000545951.1_Missense_Mutation_p.D743N|FAM193A_ENST00000382839.3_Missense_Mutation_p.D743N|FAM193A_ENST00000502458.1_Missense_Mutation_p.D765N	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	743										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						CAGTGACCCTGACTGCGAAGG	0.582000													3	18					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46331129	46331129	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:46331129G>A	ENST00000245934.7	-	15	2277	c.2033C>T	c.(2032-2034)gCc>gTc	p.A678V		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	678					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding	p.A678V(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CACCTCCAGGGCACTCTCTGT	0.652000													4	190					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58318283	58318283	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr20:58318283G>C	ENST00000371015.1	+	2	707	c.240G>C	c.(238-240)tgG>tgC	p.W80C	PHACTR3_ENST00000361300.4_Missense_Mutation_p.W39C|PHACTR3_ENST00000395636.2_Missense_Mutation_p.W39C|PHACTR3_ENST00000395639.4_Missense_Mutation_p.W39C|PHACTR3_ENST00000359926.3_Missense_Mutation_p.W77C|PHACTR3_ENST00000355648.4_Missense_Mutation_p.W39C|PHACTR3_ENST00000541461.1_Missense_Mutation_p.W39C	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	80						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CCTGGAAATGGAGGAAAAAGA	0.562000													8	59					0	0	1	0	0
C17orf70	80233	broad.mit.edu	37	17	79516278	79516278	+	Nonsense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:79516278G>A	ENST00000537152.1	-	4	1429	c.904C>T	c.(904-906)Cag>Tag	p.Q302*	C17orf70_ENST00000327787.8_Nonsense_Mutation_p.Q453*	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	453					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			TTTATTTTCTGACCTGCACTC	0.607000													4	51					0	0	1	0	0
LRRC47	57470	broad.mit.edu	37	1	3712429	3712429	+	Silent	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:3712429G>C	ENST00000378251.1	-	1	639	c.612C>G	c.(610-612)ctC>ctG	p.L204L		NM_020710.2	NP_065761.1	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	204					translation		phenylalanine-tRNA ligase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	17	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		CGCTGACCTTGAGCGAGGCCA	0.701000													4	3					0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30632611	30632611	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:30632611C>T	ENST00000376442.3	-	7	1479	c.1284G>A	c.(1282-1284)aaG>aaA	p.K428K		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	428	Helicase ATP-binding.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						TCTGGGTGGTCTTCCCTGAGC	0.557000													7	74					0	0	1	0	0
LRRC8D	55144	broad.mit.edu	37	1	90399323	90399323	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:90399323G>C	ENST00000337338.5	+	3	1103	c.696G>C	c.(694-696)caG>caC	p.Q232H	LRRC8D_ENST00000394593.3_Missense_Mutation_p.Q232H	NM_001134479.1	NP_001127951.1	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member D	232						integral to membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(2)|skin(1)	29		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		CAGGTGCCCAGACTCTACCAA	0.453000													9	47					0	0	1	0	0
LRRC47	57470	broad.mit.edu	37	1	3712633	3712633	+	Silent	SNP	G	G	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:3712633G>T	ENST00000378251.1	-	1	435	c.408C>A	c.(406-408)ctC>ctA	p.L136L		NM_020710.2	NP_065761.1	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	136					translation		phenylalanine-tRNA ligase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	17	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		GGTTGCCGCTGAGGTTGAGGC	0.736000													4	1					0.184627	0.184627	1	1	0
KIF4B	285643	broad.mit.edu	37	5	154393830	154393830	+	Silent	SNP	A	A	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr5:154393830A>G	ENST00000435029.4	+	1	571	c.411A>G	c.(409-411)aaA>aaG	p.K137K		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	137	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTACTCTGAAAGTGTCTTACT	0.373000													25	68					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163374320	163374320	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:163374320C>T	ENST00000332142.5	-	4	911	c.812G>A	c.(811-813)cGg>cAg	p.R271Q	KCNH7_ENST00000477019.1_5'UTR|KCNH7_ENST00000328032.4_Missense_Mutation_p.R271Q	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	271					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	AGATGCTCTCCGTATACTACA	0.468000													21	31					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26114709	26114709	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:26114709G>A	ENST00000313735.6	-	5	695	c.462C>T	c.(460-462)ttC>ttT	p.F154F		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	154				F -> L (in Ref. 4; AAA56666).	arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CTTACTCTTTGAAGGAGCCGT	0.527000													8	117					0	0	1	0	0
LUZP4	51213	broad.mit.edu	37	X	114537943	114537943	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:114537943C>T	ENST00000371920.3	+	3	309	c.302C>T	c.(301-303)tCt>tTt	p.S101F	LUZP4_ENST00000451986.2_Intron	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	101						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						GGATTCAAGTCTGGACAACAC	0.333000													33	124					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197398707	197398707	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:197398707C>T	ENST00000367397.1	+	4	1806	c.948C>T	c.(946-948)caC>caT	p.H316H	CRB1_ENST00000538660.1_Intron|CRB1_ENST00000535699.1_Silent_p.H911H|CRB1_ENST00000544212.1_Silent_p.H416H|CRB1_ENST00000367399.2_Silent_p.H823H|CRB1_ENST00000367400.3_Silent_p.H935H			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	935	EGF-like 8.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding	p.H935Q(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CGTGTCCTCACGGAGCCCAGT	0.532000													25	38					0	0	1	0	0
MORC4	79710	broad.mit.edu	37	X	106229364	106229364	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:106229364G>A	ENST00000355610.4	-	4	649	c.375C>T	c.(373-375)ttC>ttT	p.F125F	MORC4_ENST00000535534.1_Intron|MORC4_ENST00000255495.7_Silent_p.F125F	NM_001085354.2|NM_024657.4	NP_001078823.1|NP_078933.3	Q8TE76	MORC4_HUMAN	MORC family CW-type zinc finger 4	125							ATP binding|zinc ion binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	28						AGCCTGACTTGAAACCATTAC	0.433000													37	164					0	0	1	0	0
SIDT1	54847	broad.mit.edu	37	3	113345036	113345036	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:113345036G>A	ENST00000264852.4	+	24	3121	c.2395G>A	c.(2395-2397)Gct>Act	p.A799T	SIDT1_ENST00000393830.3_Missense_Mutation_p.A804T|SIDT1_ENST00000463226.1_3'UTR	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	799						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						CTTCCTCTCTGCTACTGCTCT	0.463000													7	105					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14822646	14822646	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr18:14822646G>A	ENST00000358984.4	+	26	2536	c.2356G>A	c.(2356-2358)Gaa>Aaa	p.E786K	RP11-1157N2__B.2_ENST00000581117.1_RNA	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	871										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TAAAGCCTTAGAATTGAAGGA	0.284000													3	7					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57111636	57111636	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr16:57111636C>T	ENST00000262510.6	+	42	5150	c.4925C>T	c.(4924-4926)tCa>tTa	p.S1642L	NLRC5_ENST00000539144.1_Missense_Mutation_p.S1613L|NLRC5_ENST00000436936.1_3'UTR|NLRC5_ENST00000308149.7_Missense_Mutation_p.S1613L	NM_032206.4	NP_115582.4	Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	1642					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				CACAGCCTCTCAGGGAATAGC	0.647000													21	52					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116340200	116340200	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:116340200C>T	ENST00000397752.3	+	2	1262	c.1062C>T	c.(1060-1062)gcC>gcT	p.A354A	MET_ENST00000436117.2_Silent_p.A354A|MET_ENST00000318493.6_Silent_p.A354A	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	354	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CAGATTCTGCCGAACCAATGG	0.473000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				12	43					0	0	1	0	0
IRAK1	3654	broad.mit.edu	37	X	153283528	153283528	+	Nonsense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:153283528G>A	ENST00000369980.3	-	7	1005	c.838C>T	c.(838-840)Cag>Tag	p.Q280*	IRAK1_ENST00000429936.2_Nonsense_Mutation_p.Q306*|IRAK1_ENST00000393682.1_Nonsense_Mutation_p.Q306*|IRAK1_ENST00000393687.2_Nonsense_Mutation_p.Q280*|IRAK1_ENST00000477274.1_5'UTR|IRAK1_ENST00000369974.2_Nonsense_Mutation_p.Q280*	NM_001025242.1|NM_001569.3	NP_001020413.1|NP_001560.2	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	280	Protein kinase.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity	p.Q280*(2)		breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(15)|ovary(2)	25	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AAGCCGTTCTGAGCACAGTAG	0.602000													12	80					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123811134	123811134	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:123811134G>A	ENST00000307033.2	+	1	885	c.811G>A	c.(811-813)Gtc>Atc	p.V271I		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V271I(1)		autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGACAAGGCCGTCTCTGTGCT	0.493000													24	109					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57869285	57869285	+	Silent	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:57869285G>C	ENST00000393797.2	-	14	1887	c.1695C>G	c.(1693-1695)ctC>ctG	p.L565L	ARHGAP9_ENST00000393791.3_Silent_p.L475L|ARHGAP9_ENST00000430041.2_Silent_p.L291L|ARHGAP9_ENST00000424809.2_Silent_p.L475L|ARHGAP9_ENST00000356411.2_Silent_p.L494L|ARHGAP9_ENST00000550288.1_Silent_p.L554L			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	494	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			GGCGGCTGCTGAGGCGCAGCA	0.731000													4	10					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46658465	46658465	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr22:46658465G>A	ENST00000253255.5	-	1	754	c.755C>T	c.(754-756)gCg>gTg	p.A252V		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	252	REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GATGGCGCGCGCGGCCGGGCA	0.706000													9	49					0	0	1	0	0
CERS2	29956	broad.mit.edu	37	1	150940946	150940946	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:150940946C>T	ENST00000271688.6	-	3	602	c.216G>A	c.(214-216)gaG>gaA	p.E72E	CERS2_ENST00000368954.5_Silent_p.E72E|CERS2_ENST00000561294.1_Silent_p.E72E|CERS2_ENST00000345896.4_5'UTR	NM_181746.3	NP_859530.1	Q96G23	CERS2_HUMAN	ceramide synthase 2	72						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GCCGAGTTTTCTCCTTTATGT	0.562000													5	71					0	0	1	0	0
LRRC47	57470	broad.mit.edu	37	1	3712433	3712433	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:3712433G>A	ENST00000378251.1	-	1	635	c.608C>T	c.(607-609)tCg>tTg	p.S203L		NM_020710.2	NP_065761.1	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	203					translation		phenylalanine-tRNA ligase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	17	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		GACCTTGAGCGAGGCCAGGTG	0.701000													4	3					0	0	1	0	0
CDC40	51362	broad.mit.edu	37	6	110514412	110514412	+	Missense_Mutation	SNP	G	G	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:110514412G>T	ENST00000368932.1	+	3	318	c.217G>T	c.(217-219)Gac>Tac	p.D73Y	CDC40_ENST00000307731.1_Missense_Mutation_p.D73Y|CDC40_ENST00000368930.1_Missense_Mutation_p.D73Y|CDC40_ENST00000368933.1_Missense_Mutation_p.D73Y			O60508	PRP17_HUMAN	cell division cycle 40	73					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm				breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)		AGTTCACCTTGACCCTGCCGT	0.338000													11	52					2.27111e-07	2.34272e-07	1	1	0
ABCC2	1244	broad.mit.edu	37	10	101604094	101604094	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr10:101604094G>A	ENST00000370449.4	+	28	3972	c.3859G>A	c.(3859-3861)Gat>Aat	p.D1287N		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1287						apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CTGGGTGACTGATAAGAGGCC	0.527000													20	39					0	0	1	0	0
CYP3A4	1576	broad.mit.edu	37	7	99370264	99370264	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:99370264C>T	ENST00000336411.2	-	4	450	c.267G>A	c.(265-267)atG>atA	p.M89I	CYP3A4_ENST00000354593.2_Intron	NM_001202855.2|NM_017460.5	NP_001189784.1|NP_059488.2	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 4	89					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			breast(3)|central_nervous_system(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	CTGTTTTGATCATGTCAGGAT	0.353000													4	120					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111632476	111632476	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:111632476G>A	ENST00000431670.2	+	3	2057	c.1646G>A	c.(1645-1647)cGg>cAg	p.R549Q	PHLDB2_ENST00000412622.1_Missense_Mutation_p.R549Q|PHLDB2_ENST00000481953.1_Missense_Mutation_p.R549Q|PHLDB2_ENST00000495180.1_Missense_Mutation_p.R135Q|PHLDB2_ENST00000477695.1_Missense_Mutation_p.R549Q|PHLDB2_ENST00000393923.3_Missense_Mutation_p.R576Q|PHLDB2_ENST00000393925.3_Missense_Mutation_p.R549Q	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	549						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GACCTCACCCGGACTCCTCCA	0.522000													6	208					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	A	G	rs141732548	by1000genomes	TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr21:14414855A>G	ENST00000507941.1	+	0	95																											GCCAATGGCCATGCAGAAGTA	0.448000													4	43					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9546591	9546591	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr20:9546591C>T	ENST00000378429.3	-	6	1977	c.1431G>A	c.(1429-1431)gtG>gtA	p.V477V	PAK7_ENST00000378423.1_Silent_p.V477V|PAK7_ENST00000353224.5_Silent_p.V477V	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	477	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			CCATTTTCTTCACTGCAACTT	0.458000													50	127					0	0	1	0	0
ZNF546	339327	broad.mit.edu	37	19	40521147	40521147	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:40521147G>C	ENST00000347077.4	+	7	2186	c.1970G>C	c.(1969-1971)aGa>aCa	p.R657T	ZNF546_ENST00000600094.1_Missense_Mutation_p.R631T|ZNF546_ENST00000596894.1_Intron	NM_178544.3	NP_848639.2	Q86UE3	ZN546_HUMAN	zinc finger protein 546	657					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R657I(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(15)|lung(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	34	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CAACATCACAGAATTCATACT	0.433000													4	39					0	0	1	0	0
HMG20B	10362	broad.mit.edu	37	19	3578065	3578065	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:3578065G>A	ENST00000333651.6	+	9	970	c.895G>A	c.(895-897)Gag>Aag	p.E299K		NM_006339.2	NP_006330.2	Q9P0W2	HM20B_HUMAN	high mobility group 20B	299					blood coagulation|cell cycle|chromatin modification	chromosome|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCCAGCACGAGAAGCTCAT	0.706000													5	31					0	0	1	0	0
ENO3	2027	broad.mit.edu	37	17	4858564	4858564	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:4858564C>T	ENST00000323997.6	+	7	771	c.639C>T	c.(637-639)ttC>ttT	p.F213F	ENO3_ENST00000518175.1_Silent_p.F213F|ENO3_ENST00000519584.1_Silent_p.F170F	NM_001976.4|NM_053013.3	NP_001967.3|NP_443739.3	P13929	ENOB_HUMAN	enolase 3 (beta, muscle)	213					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)	15						AAGGTGGCTTCGCACCCAACA	0.607000													13	45					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8828905	8828905	+	Splice_Site	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr18:8828905G>A	ENST00000359865.3	+	16	4864		c.e16-1		SOGA2_ENST00000518815.1_Intron|SOGA2_ENST00000517570.1_Splice_Site|SOGA2_ENST00000306285.7_Intron|SOGA2_ENST00000400050.3_Splice_Site|SOGA2_ENST00000306329.11_Splice_Site	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2																		GTTCTGTCCAGAACCAAACTG	0.483000													11	55					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21117520	21117520	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr10:21117520G>C	ENST00000377122.4	-	17	2111	c.1715C>G	c.(1714-1716)tCt>tGt	p.S572C	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	572					regulation of actin filament length		actin binding|structural constituent of muscle	p.S572F(1)		NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TGCTATGGTAGAATAGTTAGA	0.343000													6	20					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113325692	113325692	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:113325692G>C	ENST00000389385.4	+	17	2024	c.1527G>C	c.(1525-1527)agG>agC	p.R509S	RPH3A_ENST00000420983.2_Missense_Mutation_p.R509S|RPH3A_ENST00000551052.1_Missense_Mutation_p.R505S|RPH3A_ENST00000543106.2_Missense_Mutation_p.R509S|RPH3A_ENST00000549913.2_3'UTR|RPH3A_ENST00000447659.2_Missense_Mutation_p.R460S|RPH3A_ENST00000548866.1_Missense_Mutation_p.R460S|RPH3A_ENST00000415485.3_Missense_Mutation_p.R509S	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	509					intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		CCAACCAGAGGAAGAATTTCA	0.502000													4	182					0	0	1	0	0
TRPV1	7442	broad.mit.edu	37	17	3494382	3494382	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:3494382C>T	ENST00000174621.6	-	3	763	c.474G>A	c.(472-474)ctG>ctA	p.L158L	TRPV1_ENST00000399756.4_Silent_p.L160L|TRPV1_ENST00000576351.1_Silent_p.L160L|SHPK_ENST00000572705.1_Silent_p.L160L|TRPV1_ENST00000425167.2_Silent_p.L160L|TRPV1_ENST00000399759.3_Silent_p.L160L|TRPV1_ENST00000310522.5_Silent_p.L160L|TRPV1_ENST00000571088.1_Silent_p.L160L			Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel, subfamily V, member 1	160					cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	17				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	GCATGGCTTTCAGCAGACAGG	0.637000													5	16					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183083794	183083794	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:183083794G>C	ENST00000258341.4	+	5	1407	c.1150G>C	c.(1150-1152)Gag>Cag	p.E384Q		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	384	Laminin EGF-like 2.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGGTGCCGAGAGAACTTCTT	0.512000													6	116					0	0	1	0	0
FCGR2A	2212	broad.mit.edu	37	1	161480678	161480678	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:161480678C>T	ENST00000271450.6	+	5	712	c.674C>T	c.(673-675)gCg>gTg	p.A225V	FCGR2A_ENST00000467525.1_3'UTR|FCGR2A_ENST00000367972.4_Missense_Mutation_p.A224V	NM_001136219.1|NM_021642.3	NP_001129691.1|NP_067674.2	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor (CD32)	225						integral to membrane|plasma membrane	IgG binding|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)	19	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GTGGTCATTGCGACTGCTGTA	0.502000													67	167					0	0	1	0	0
ADCY4	196883	broad.mit.edu	37	14	24789048	24789048	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:24789048G>A	ENST00000310677.4	-	22	2746	c.2633C>T	c.(2632-2634)tCa>tTa	p.S878L	ADCY4_ENST00000418030.2_Missense_Mutation_p.S878L|ADCY4_ENST00000554068.2_Missense_Mutation_p.S878L	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	878					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		GTCTGGGACTGAGGCGAAGAG	0.493000													6	48					0	0	1	0	0
CAPS	828	broad.mit.edu	37	19	5914728	5914728	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:5914728G>C	ENST00000588776.1	+	3	2863	c.496G>C	c.(496-498)Gag>Cag	p.E166Q	CAPS_ENST00000222125.5_Missense_Mutation_p.E80Q|CAPS_ENST00000452990.2_Missense_Mutation_p.E80Q			Q13938	CAYP1_HUMAN	calcyphosine	80	EF-hand 4.				intracellular signal transduction	cytoplasm	calcium ion binding			cervix(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	4						GCTGGATCTGGAGGAGTTCCT	0.677000													4	127					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98563391	98563391	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:98563391G>A	ENST00000359863.4	+	48	7237	c.7028G>A	c.(7027-7029)cGg>cAg	p.R2343Q	TRRAP_ENST00000355540.3_Missense_Mutation_p.R2325Q|TRRAP_ENST00000446306.3_Missense_Mutation_p.R2325Q	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2343	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ATGGAGATGCGGAAGAACTTC	0.527000													11	50					0	0	1	0	0
HSPB8	26353	broad.mit.edu	37	12	119617124	119617124	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:119617124G>A	ENST00000281938.2	+	1	678	c.7G>A	c.(7-9)Gac>Aac	p.D3N		NM_014365.2	NP_055180.1	Q9UJY1	HSPB8_HUMAN	heat shock 22kDa protein 8	3					cell death|response to heat	cytoplasm|nucleus	identical protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	14	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CACCATGGCTGACGGTCAGAT	0.607000													7	137					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44571799	44571799	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:44571799G>A	ENST00000289547.4	-	9	2482	c.2427C>T	c.(2425-2427)gtC>gtT	p.V809V	NPC1L1_ENST00000381160.3_Silent_p.V809V|NPC1L1_ENST00000546276.1_Silent_p.V809V	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	809					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	CACAGCAGCAGACGTCCAACC	0.652000													30	89					0	0	1	0	0
MAZ	4150	broad.mit.edu	37	16	29818686	29818686	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr16:29818686C>G	ENST00000219782.6	+	2	686	c.580C>G	c.(580-582)Ctg>Gtg	p.L194V	MAZ_ENST00000322945.6_Missense_Mutation_p.L194V|MAZ_ENST00000566906.2_Intron|AC009133.15_ENST00000566537.1_RNA|MAZ_ENST00000562337.1_Intron|MAZ_ENST00000545521.1_Missense_Mutation_p.L171V|MAZ_ENST00000563402.1_Intron	NM_001042539.1	NP_001036004.1	P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	194					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						CATCTGCGCTCTGTGCGCCAA	0.647000													10	19					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26493171	26493171	+	Nonsense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:26493171G>A	ENST00000381340.3	-	56	8364	c.7948C>T	c.(7948-7950)Cag>Tag	p.Q2650*	RP11-513G19.1_ENST00000535324.1_RNA	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	2650					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					AACTTCTCCTGAAGGCTCCGA	0.532000													12	68					0	0	1	0	0
EGLN1	54583	broad.mit.edu	37	1	231557041	231557041	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:231557041G>A	ENST00000366641.3	-	1	3749	c.594C>T	c.(592-594)atC>atT	p.I198I		NM_022051.2	NP_071334.1	Q9GZT9	EGLN1_HUMAN	egl-9 family hypoxia-inducible factor 1	198					negative regulation of sequence-specific DNA binding transcription factor activity|oxygen homeostasis|response to hypoxia	cytosol	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline dioxygenase activity|protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	16		Prostate(94;0.194)|Acute lymphoblastic leukemia(190;0.244)			Vitamin C(DB00126)	TGCACGGCACGATGTACTCGA	0.687000													12	21					0	0	1	0	0
ITPA	3704	broad.mit.edu	37	20	3199199	3199199	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr20:3199199C>T	ENST00000380113.3	+	6	524	c.332C>T	c.(331-333)tCa>tTa	p.S111L	ITPA_ENST00000483354.1_3'UTR|ITPA_ENST00000455664.1_Missense_Mutation_p.S94L|ITPA_ENST00000399838.3_Missense_Mutation_p.S70L	NM_033453.3	NP_258412.1	Q9BY32	ITPA_HUMAN	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	111					nucleotide metabolic process	cytoplasm	metal ion binding|nucleoside-triphosphate diphosphatase activity|nucleotide binding			autonomic_ganglia(1)|large_intestine(3)|ovary(1)|stomach(1)	6						GAGGACAAGTCAGCCTATGCG	0.652000											OREG0025730	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	60					0	0	1	0	0
FARP1	10160	broad.mit.edu	37	13	99037976	99037976	+	Nonsense_Mutation	SNP	G	G	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr13:99037976G>T	ENST00000376586.2	+	8	1003	c.667G>T	c.(667-669)Gag>Tag	p.E223*	FARP1_ENST00000319562.6_Nonsense_Mutation_p.E223*|FARP1_ENST00000595437.1_Nonsense_Mutation_p.E223*			Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	223	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(3)|endometrium(6)|kidney(6)|large_intestine(13)|lung(16)|ovary(1)|skin(3)|urinary_tract(1)	49	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			CCGTCGGCTAGAGATGTATGG	0.488000													19	91					1.2644e-06	1.29842e-06	1	1	0
CSF1R	1436	broad.mit.edu	37	5	149439334	149439334	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr5:149439334C>T	ENST00000286301.3	-	15	2352	c.2061G>A	c.(2059-2061)ctG>ctA	p.L687L		NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	687	Protein kinase.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	GGCCGGGGCTCAGGCTGGGTC	0.577000													7	95					0	0	1	0	0
SIM2	6493	broad.mit.edu	37	21	38114091	38114091	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr21:38114091G>C	ENST00000290399.6	+	8	1537	c.924G>C	c.(922-924)caG>caC	p.Q308H	SIM2_ENST00000430056.3_Missense_Mutation_p.Q308H	NM_005069.3	NP_005060.1	Q14190	SIM2_HUMAN	single-minded family bHLH transcription factor 2	308	PAC.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(6)|prostate(1)|skin(2)	16						TGTGGGTGCAGAGCTACGCCA	0.582000													6	14					0	0	1	0	0
KRT14	3861	broad.mit.edu	37	17	39739910	39739910	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:39739910C>T	ENST00000167586.6	-	5	1032	c.946G>A	c.(946-948)Gag>Aag	p.E316K		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	316	Coil 2.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				GTGGCCACCTCGCGGTTCAGC	0.587000													24	177					0	0	1	0	0
KRT14	3861	broad.mit.edu	37	17	39740126	39740126	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:39740126C>T	ENST00000167586.6	-	4	899	c.813G>A	c.(811-813)gaG>gaA	p.E271E		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	271	Linker 12.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				CAGCGTCCATCTCCACATTGA	0.572000													20	136					0	0	1	0	0
SOCS6	9306	broad.mit.edu	37	18	67992445	67992445	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr18:67992445G>C	ENST00000397942.3	+	2	857	c.541G>C	c.(541-543)Gag>Cag	p.E181Q	SOCS6_ENST00000582322.1_Missense_Mutation_p.E181Q	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	181					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				CCTCCAGTCTGAGACCACGTG	0.542000													22	65					0	0	1	0	0
STEAP4	79689	broad.mit.edu	37	7	87908879	87908879	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:87908879C>G	ENST00000380079.4	-	5	1315	c.1214G>C	c.(1213-1215)aGa>aCa	p.R405T	AC003991.3_ENST00000595121.1_RNA|AC003991.3_ENST00000447758.1_RNA|AC003991.3_ENST00000434733.1_RNA|STEAP4_ENST00000301959.5_Missense_Mutation_p.R229T|AC003991.3_ENST00000600908.1_RNA	NM_001205315.1|NM_024636.3	NP_001192244.1|NP_078912.2	Q687X5	STEA4_HUMAN	STEAP family member 4	405					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(3)	15	Esophageal squamous(14;0.00802)					GCTGAGGAATCTCTTCCCACC	0.433000													6	28					0	0	1	0	0
PFKL	5211	broad.mit.edu	37	21	45732997	45732997	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr21:45732997C>T	ENST00000403390.1	+	6	705	c.705C>T	c.(703-705)gtC>gtT	p.V235V	PFKL_ENST00000496824.1_3'UTR|PFKL_ENST00000349048.4_Silent_p.V188V			P17858	K6PL_HUMAN	phosphofructokinase, liver	188					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		TCATGGAGGTCATCGATGCCA	0.667000													22	104					0	0	1	0	0
SYT14	255928	broad.mit.edu	37	1	210267850	210267850	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:210267850G>A	ENST00000537238.1	+	6	903	c.512G>A	c.(511-513)gGa>gAa	p.G171E	SYT14_ENST00000271745.7_3'UTR|SYT14_ENST00000367019.1_Missense_Mutation_p.G209E|SYT14_ENST00000367015.1_Missense_Mutation_p.G171E|SYT14_ENST00000399639.2_Missense_Mutation_p.G209E|SYT14_ENST00000422431.1_Missense_Mutation_p.G254E|SYT14_ENST00000472886.1_Missense_Mutation_p.G209E|SYT14_ENST00000534859.1_Missense_Mutation_p.G209E	NM_001256006.1|NM_153262.3	NP_001242935.1|NP_694994.2	Q8NB59	SYT14_HUMAN	synaptotagmin XIV	209						integral to membrane				endometrium(4)|large_intestine(11)|lung(17)|ovary(1)|prostate(1)|skin(3)	37				OV - Ovarian serous cystadenocarcinoma(81;0.085)		CCAAGTGAAGGAAGCACAGGT	0.418000													4	61					0	0	1	0	0
BFSP2	8419	broad.mit.edu	37	3	133193815	133193815	+	Nonstop_Mutation	SNP	G	G	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:133193815G>T	ENST00000302334.2	+	7	1336	c.1247G>T	c.(1246-1248)tGa>tTa	p.*416L		NM_003571.2	NP_003562.1	Q13515	BFSP2_HUMAN	beaded filament structural protein 2, phakinin	0					response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|urinary_tract(1)	13						CCTTTCAGCTGATGGAGAAAC	0.458000													13	108					0.0135373	0.0135967	1	1	0
GCKR	2646	broad.mit.edu	37	2	27730628	27730628	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr2:27730628C>G	ENST00000264717.2	+	14	1287	c.1224C>G	c.(1222-1224)ttC>ttG	p.F408L	GCKR_ENST00000424318.2_Missense_Mutation_p.F218L	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	408	SIS 2.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					CTGTGGTCTTCATTTTCACCC	0.537000													8	46					0	0	1	0	0
RALGDS	5900	broad.mit.edu	37	9	135985758	135985758	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr9:135985758G>C	ENST00000393160.3	-	3	601	c.248C>G	c.(247-249)tCc>tGc	p.S83C	RALGDS_ENST00000372047.3_Missense_Mutation_p.S138C|RALGDS_ENST00000372062.3_Missense_Mutation_p.S121C|RALGDS_ENST00000542690.1_Missense_Mutation_p.S209C|RALGDS_ENST00000372050.3_Missense_Mutation_p.S138C|RALGDS_ENST00000393157.3_Missense_Mutation_p.S137C	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	138					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		GGTGACGTAGGAGAGGTCGCT	0.577000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								6	42					0	0	1	0	0
AFF1	4299	broad.mit.edu	37	4	87968606	87968606	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr4:87968606C>T	ENST00000307808.6	+	3	1318	c.898C>T	c.(898-900)Caa>Taa	p.Q300*	AFF1_ENST00000395146.4_Nonsense_Mutation_p.Q307*|AFF1_ENST00000544085.1_Intron	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	300						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		CATGGATGGTCAAGATCAGGC	0.542000													29	180					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50142523	50142523	+	Silent	SNP	A	A	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:50142523A>G	ENST00000347869.3	+	9	817	c.642A>G	c.(640-642)gaA>gaG	p.E214E		NM_005778.3	NP_005769.1	P52756	RBM5_HUMAN	RNA binding motif protein 5	214					apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTGAACAGGAAGTGCCTCCTG	0.368000													3	19					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52260496	52260496	+	Splice_Site	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:52260496C>T	ENST00000354831.7	-	25	3028	c.2840_splice	c.e25+1	p.D947_splice	NRD1_ENST00000544028.1_3'UTR|NRD1_ENST00000485608.1_5'UTR|NRD1_ENST00000352171.7_Splice_Site_p.D879_splice|RP4-657D16.3_ENST00000588291.1_RNA|NRD1_ENST00000539524.1_Splice_Site_p.D815_splice|RP4-657D16.3_ENST00000586761.1_RNA	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	878					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						AATACTTACTCAACAACATAT	0.358000													13	58					0	0	1	0	0
PRPF40B	25766	broad.mit.edu	37	12	50030561	50030561	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:50030561G>C	ENST00000261897.1	+	15	1956	c.1405G>C	c.(1405-1407)Gag>Cag	p.E469Q	PRPF40B_ENST00000380281.1_Missense_Mutation_p.E475Q|PRPF40B_ENST00000548825.2_Missense_Mutation_p.E497Q			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	475					mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						GGAGAGGGAAGAGGAGGAGGA	0.567000											OREG0021797	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	119					0	0	1	0	0
NHP2L1	4809	broad.mit.edu	37	22	42071006	42071006	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr22:42071006G>C	ENST00000401959.1	-	4	634	c.318C>G	c.(316-318)atC>atG	p.I106M	NHP2L1_ENST00000402458.1_Missense_Mutation_p.I110M|NHP2L1_ENST00000355257.3_Missense_Mutation_p.I106M|NHP2L1_ENST00000463675.1_5'UTR|NHP2L1_ENST00000215956.5_Missense_Mutation_p.I106M	NM_005008.3	NP_004999.1	P55769	NH2L1_HUMAN	NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)	106					nuclear mRNA splicing, via spliceosome|ribosome biogenesis	box C/D snoRNP complex|nucleoplasm|spliceosomal complex	protein binding|RNA binding			endometrium(1)|kidney(1)|lung(1)|prostate(1)	4						AGCCTTCTTTGATGGTGACAG	0.557000													7	83					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152815068	152815068	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:152815068C>T	ENST00000370186.1	+	9	1736	c.1410C>T	c.(1408-1410)acC>acT	p.T470T	ATP2B3_ENST00000359149.3_Silent_p.T484T|ATP2B3_ENST00000349466.2_Silent_p.T484T|ATP2B3_ENST00000263519.4_Silent_p.T484T|ATP2B3_ENST00000393842.1_Silent_p.T470T|ATP2B3_ENST00000370181.2_Silent_p.T470T			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	484					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ACCGTATGACCGTGGTCCAGT	0.612000													39	119					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13138131	13138131	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr9:13138131C>G	ENST00000319217.7	-	29	4272	c.4025G>C	c.(4024-4026)gGa>gCa	p.G1342A	MPDZ_ENST00000541718.1_Missense_Mutation_p.G1342A|MPDZ_ENST00000381022.2_Missense_Mutation_p.G1342A|MPDZ_ENST00000540202.1_5'UTR|MPDZ_ENST00000381015.4_Missense_Mutation_p.G1342A|MPDZ_ENST00000447879.1_Missense_Mutation_p.G1309A|MPDZ_ENST00000536827.1_Missense_Mutation_p.G1309A|MPDZ_ENST00000538841.1_Missense_Mutation_p.G201A|MPDZ_ENST00000546205.1_Missense_Mutation_p.G1356A	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1342					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		TGTTAGGGTTCCATAACGCTC	0.393000													4	24					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26493139	26493139	+	Silent	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:26493139G>C	ENST00000381340.3	-	56	8396	c.7980C>G	c.(7978-7980)gtC>gtG	p.V2660V	RP11-513G19.1_ENST00000535324.1_RNA	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	2660					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					ACAGCTGTTTGACCAGACTCA	0.552000													18	75					0	0	1	0	0
ACAD8	27034	broad.mit.edu	37	11	134128475	134128475	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:134128475C>T	ENST00000281182.4	+	4	553	c.447C>T	c.(445-447)ctC>ctT	p.L149L	ACAD8_ENST00000543332.1_Silent_p.L51L|ACAD8_ENST00000537423.1_Silent_p.L72L|ACAD8_ENST00000524547.1_Intron|ACAD8_ENST00000374752.4_Intron	NM_014384.2	NP_055199.1	Q9UKU7	ACAD8_HUMAN	acyl-CoA dehydrogenase family, member 8	149					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		GCCCACCGCTCTGTACCATGG	0.473000													5	18					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501704	140501704	+	Missense_Mutation	SNP	T	T	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr5:140501704T>C	ENST00000194152.1	+	1	124	c.124T>C	c.(124-126)Tcc>Ccc	p.S42P		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		42	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGAGCGGCTCCTTTGTAGC	0.542000													4	76					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15769314	15769314	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:15769314C>T	ENST00000221307.7	+	11	1311	c.1263C>T	c.(1261-1263)ctC>ctT	p.L421L	CYP4F3_ENST00000585846.1_Silent_p.L421L|CYP4F3_ENST00000586182.1_Silent_p.L421L|CYP4F3_ENST00000591058.1_Silent_p.L421L	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	421					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						TTATCTGCCTCATCAGTGTTT	0.612000													8	265					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186442879	186442879	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:186442879G>A	ENST00000265023.4	+	4	606	c.394G>A	c.(394-396)Gag>Aag	p.E132K	KNG1_ENST00000447445.1_Missense_Mutation_p.E132K|KNG1_ENST00000287611.2_Missense_Mutation_p.E132K|RP11-573D15.8_ENST00000599314.1_RNA	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	132	Cystatin 1.|O-glycosylated at one site only.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding	p.E132K(2)		endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	TTGTTAAGCCGAGGGCCCTGT	0.532000													13	29					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13616234	13616234	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr4:13616234C>G	ENST00000040738.5	-	4	895	c.760G>C	c.(760-762)Gag>Cag	p.E254Q		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	254							DNA binding										GCCATGTCCTCTGAAGTTCTT	0.453000													3	37					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85434298	85434298	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr12:85434298C>T	ENST00000393217.2	+	3	224	c.163C>T	c.(163-165)Cac>Tac	p.H55Y		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	55										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		ATCAGTTCTTCACTGTATTAA	0.303000													7	45					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20749634	20749634	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr22:20749634C>T	ENST00000400451.2	+	2	560	c.46C>T	c.(46-48)Cag>Tag	p.Q16*	ZNF74_ENST00000403682.3_Intron|ZNF74_ENST00000405993.1_Nonsense_Mutation_p.Q16*|ZNF74_ENST00000357502.5_Missense_Mutation_p.S21L|ZNF74_ENST00000356671.5_Nonsense_Mutation_p.Q16*	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	16					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TCTTTCCTCTCAGGATCCTGC	0.532000													30	104					0	0	1	0	0
SOCS6	9306	broad.mit.edu	37	18	67992151	67992151	+	Missense_Mutation	SNP	G	G	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr18:67992151G>T	ENST00000397942.3	+	2	563	c.247G>T	c.(247-249)Gca>Tca	p.A83S	SOCS6_ENST00000582322.1_Missense_Mutation_p.A83S	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	83					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				GCGGCTTTCTGCAAAACAGAA	0.507000													18	111					3.5997e-14	3.8341e-14	1	1	0
TIAM2	26230	broad.mit.edu	37	6	155532355	155532355	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:155532355G>C	ENST00000461783.3	+	17	4355	c.3082G>C	c.(3082-3084)Gat>Cat	p.D1028H	TIAM2_ENST00000528391.2_Missense_Mutation_p.D364H|TIAM2_ENST00000456144.1_Missense_Mutation_p.D1028H|TIAM2_ENST00000456877.2_Missense_Mutation_p.D340H|TIAM2_ENST00000360366.4_Missense_Mutation_p.D1052H|TIAM2_ENST00000318981.5_Missense_Mutation_p.D1028H|TIAM2_ENST00000529824.2_Missense_Mutation_p.D1028H|TIAM2_ENST00000367174.2_Missense_Mutation_p.D404H			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1028					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CAACGTCCCTGATATCACAAC	0.433000													16	28					0	0	1	0	0
ZNF750	79755	broad.mit.edu	37	17	80790229	80790229	+	Nonsense_Mutation	SNP	G	G	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:80790229G>T	ENST00000269394.3	-	2	935	c.102C>A	c.(100-102)tgC>tgA	p.C34*	TBCD_ENST00000397466.2_Intron|ZNF750_ENST00000572562.1_Intron|TBCD_ENST00000539345.2_Intron|TBCD_ENST00000355528.4_Intron	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	34						intracellular	zinc ion binding			NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			ACTTCTCATTGCAAGTAAAGG	0.413000													40	49					5.04308e-16	5.39657e-16	1	1	0
OR2AK2	391191	broad.mit.edu	37	1	248128891	248128891	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:248128891C>T	ENST00000366480.3	+	1	357	c.258C>T	c.(256-258)ctC>ctT	p.L86L	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TCGTTGACCTCATGTACATCT	0.468000													6	108					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42794548	42794548	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:42794548C>T	ENST00000572681.2	+	11	4423	c.4355C>T	c.(4354-4356)tCa>tTa	p.S1452L	CIC_ENST00000575354.2_Missense_Mutation_p.S543L|CIC_ENST00000160740.3_Missense_Mutation_p.S543L			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	543					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GCTTCCTCCTCAGCCTCGGCA	0.677000			"""Mis, F, S"""		oligodendroglioma								30	87					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18729586	18729586	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr8:18729586G>A	ENST00000440756.2	-	3	890	c.788C>T	c.(787-789)gCa>gTa	p.A263V	PSD3_ENST00000327040.8_Missense_Mutation_p.A263V|PSD3_ENST00000523619.1_Missense_Mutation_p.A198V			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	263					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		AACACTGCCTGCAGAGTGGCA	0.582000													8	53					0	0	1	0	0
RIOK1	83732	broad.mit.edu	37	6	7402876	7402876	+	Missense_Mutation	SNP	G	G	C	rs148276498		TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:7402876G>C	ENST00000379834.2	+	7	1121	c.614G>C	c.(613-615)aGa>aCa	p.R205T		NM_031480.2|NM_153005.1	NP_113668.2|NP_694550.1	Q9BRS2	RIOK1_HUMAN	RIO kinase 1	205	Protein kinase.						ATP binding|protein serine/threonine kinase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19	Ovarian(93;0.0418)					GGAGAGAGCAGAGCAATCAAA	0.318000													20	93					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20129232	20129232	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:20129232C>T	ENST00000396085.1	+	37	7234	c.6873C>T	c.(6871-6873)tgC>tgT	p.C2291C	NAV2_ENST00000360655.4_Silent_p.C2224C|NAV2_ENST00000349880.4_Silent_p.C2288C|NAV2_ENST00000527559.2_Silent_p.C2276C|NAV2_ENST00000533917.1_Silent_p.C1352C|NAV2_ENST00000311043.8_Silent_p.C1352C|NAV2_ENST00000396087.3_Silent_p.C2347C|NAV2_ENST00000540292.1_Silent_p.C2278C	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	2347						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						TCCTGTCATGCCCCATCGATG	0.552000													5	460					0	0	1	0	0
MROH8	140699	broad.mit.edu	37	20	35742407	35742407	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr20:35742407C>T	ENST00000400441.3	-	20	2676	c.2677G>A	c.(2677-2679)Gat>Aat	p.D893N	MROH8_ENST00000441008.2_Missense_Mutation_p.D879N|MROH8_ENST00000217333.8_Missense_Mutation_p.D722N					maestro heat-like repeat family member 8																		GCTACTGCATCATTTTCATCC	0.433000													5	37					0	0	1	0	0
C3orf56	285311	broad.mit.edu	37	3	126915966	126915966	+	Silent	SNP	C	C	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:126915966C>A	ENST00000398112.1	+	2	678	c.438C>A	c.(436-438)ggC>ggA	p.G146G		NM_001007534.2	NP_001007535.1			chromosome 3 open reading frame 56											breast(1)|endometrium(2)|kidney(1)|lung(5)	9				GBM - Glioblastoma multiforme(114;0.142)		CCACTCTGGGCGGGGCCACCT	0.627000													4	183					0.00909568	0.00917582	1	1	0
HNRNPD	3184	broad.mit.edu	37	4	83280732	83280732	+	Missense_Mutation	SNP	A	A	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr4:83280732A>T	ENST00000313899.7	-	3	628	c.351T>A	c.(349-351)ttT>ttA	p.F117L	HNRNPD_ENST00000543098.1_Missense_Mutation_p.F65L|HNRNPD_ENST00000541060.1_Intron|HNRNPD_ENST00000353341.4_Missense_Mutation_p.F117L|HNRNPD_ENST00000352301.4_Missense_Mutation_p.F98L	NM_031370.2	NP_112738.1	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	117	RRM 1.				nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	7						CAAATTTGGAAAAGTAGTCCT	0.378000													17	60					0	0	1	0	0
CDC45	8318	broad.mit.edu	37	22	19470230	19470230	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr22:19470230C>T	ENST00000407835.1	+	5	478	c.222C>T	c.(220-222)ctC>ctT	p.L74L	CDC45_ENST00000437685.2_Silent_p.L74L|CDC45_ENST00000263201.1_Silent_p.L74L|CDC45_ENST00000404724.3_Intron|CDC45_ENST00000483431.1_3'UTR			O75419	CDC45_HUMAN	cell division cycle 45	74					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	19						ATTTTATTCTCATAAACTGTG	0.383000													4	81					0	0	1	0	0
ZFAND4	93550	broad.mit.edu	37	10	46122283	46122283	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr10:46122283G>C	ENST00000374366.3	-	8	1231	c.766C>G	c.(766-768)Cac>Gac	p.H256D	ZFAND4_ENST00000344646.5_Missense_Mutation_p.H330D|ZFAND4_ENST00000374371.2_Intron|ZFAND4_ENST00000374370.1_5'UTR			Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	330							zinc ion binding										CTACTGAAGTGAGACAGTGTG	0.433000													5	50					0	0	1	0	0
ADCY4	196883	broad.mit.edu	37	14	24789008	24789008	+	Silent	SNP	G	G	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr14:24789008G>T	ENST00000310677.4	-	22	2786	c.2673C>A	c.(2671-2673)atC>atA	p.I891I	ADCY4_ENST00000418030.2_Silent_p.I891I|ADCY4_ENST00000554068.2_Silent_p.I891I	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	891					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		CCTCATGATTGATGTTGGATT	0.473000													6	44					3.59834e-05	3.67866e-05	1	1	0
RIOK1	83732	broad.mit.edu	37	6	7403092	7403092	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:7403092G>A	ENST00000379834.2	+	8	1236	c.729G>A	c.(727-729)gtG>gtA	p.V243V		NM_031480.2|NM_153005.1	NP_113668.2|NP_694550.1	Q9BRS2	RIOK1_HUMAN	RIO kinase 1	243	Protein kinase.						ATP binding|protein serine/threonine kinase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19	Ovarian(93;0.0418)					GGAAAATGGTGAAAACTTGGG	0.353000													6	40					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123811260	123811260	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:123811260G>A	ENST00000307033.2	+	1	1011	c.937G>A	c.(937-939)Gag>Aag	p.E313K		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	313					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TGGTCCCCTGGAGCACAGACC	0.493000													5	102					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70387117	70387117	+	Silent	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:70387117C>G	ENST00000374051.3	+	6	1432	c.1110C>G	c.(1108-1110)ctC>ctG	p.L370L	NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000536169.1_Silent_p.L350L|NLGN3_ENST00000358741.3_Silent_p.L390L	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	390					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					CTGAGATCCTCATGGAGCAGG	0.567000													14	52					0	0	1	0	0
OR4B1	119765	broad.mit.edu	37	11	48238859	48238859	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:48238859C>T	ENST00000309562.2	+	1	516	c.498C>T	c.(496-498)ttC>ttT	p.F166F		NM_001005470.1	NP_001005470.1	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B, member 1	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						AATTGCCCTTCTGTGGTCCCA	0.488000													20	81					0	0	1	0	0
DHX38	9785	broad.mit.edu	37	16	72139145	72139145	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr16:72139145G>C	ENST00000268482.3	+	17	2786	c.2277G>C	c.(2275-2277)caG>caC	p.Q759H	DHX38_ENST00000536867.1_Intron	NM_014003.3	NP_054722.2	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	759	Helicase C-terminal.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(5)|kidney(1)|large_intestine(16)|lung(15)|pancreas(1)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	48		Ovarian(137;0.125)				CCTCAGACCAGATTGTGGAGC	0.567000													12	23					0	0	1	0	0
DNASE1L1	1774	broad.mit.edu	37	X	153631068	153631068	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chrX:153631068G>C	ENST00000369809.1	-	10	1518	c.889C>G	c.(889-891)Cag>Gag	p.Q297E	DNASE1L1_ENST00000393638.1_Missense_Mutation_p.Q297E	NM_001009932.1	NP_001009932.1	P49184	DNSL1_HUMAN	deoxyribonuclease I-like 1	297					DNA catabolic process	endoplasmic reticulum	DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			lung(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGCACAGCTGAGGGGACAGG	0.652000													6	34					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144879256	144879256	+	Silent	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:144879256C>T	ENST00000369359.4	-	30	4640	c.4602G>A	c.(4600-4602)ctG>ctA	p.L1534L	PDE4DIP_ENST00000530740.1_Silent_p.L1534L|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369356.4_Silent_p.L1398L|PDE4DIP_ENST00000369354.3_Silent_p.L1398L|PDE4DIP_ENST00000313382.9_Silent_p.L1354L			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1398					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAACAGCTCTCAGCTTCCAGG	0.537000			T	PDGFRB	MPD								10	100					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585411	82585411	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr7:82585411C>G	ENST00000423517.2	-	5	5195	c.4858G>C	c.(4858-4860)Gat>Cat	p.D1620H	PCLO_ENST00000333891.8_Missense_Mutation_p.D1620H	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1551					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GCATCTTCATCAATGCTTGTG	0.413000													11	178					0	0	1	0	0
ILF2	3608	broad.mit.edu	37	1	153634912	153634912	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:153634912G>C	ENST00000361891.4	-	14	1258	c.1133C>G	c.(1132-1134)cCt>cGt	p.P378R	ILF2_ENST00000480213.1_5'UTR	NM_001267809.1|NM_004515.3	NP_001254738.1|NP_004506.2	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2	378					immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity			cervix(1)|kidney(1)|lung(4)|skin(1)	7	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			ctctccttgaggtggttcttc	0.488000													23	32					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142280234	142280234	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:142280234C>G	ENST00000350721.4	-	5	1321	c.1200G>C	c.(1198-1200)ttG>ttC	p.L400F	ATR_ENST00000383101.3_Missense_Mutation_p.L400F	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	400					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TTTCCATTTTCAAAGCTGCAT	0.348000								Other conserved DNA damage response genes					3	51					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54805384	54805384	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr6:54805384C>T	ENST00000306858.7	+	5	1731	c.1615C>T	c.(1615-1617)Cgg>Tgg	p.R539W		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	539								p.R539W(1)		autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TACTCATTCTCGGCTTCGTTC	0.413000													3	51					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65376848	65376848	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr3:65376848C>T	ENST00000330909.8	-	14	2384	c.2385G>A	c.(2383-2385)tgG>tgA	p.W795*	MAGI1_ENST00000402939.2_Nonsense_Mutation_p.W795*|MAGI1_ENST00000483466.1_Nonsense_Mutation_p.W795*|MAGI1_ENST00000497477.2_Nonsense_Mutation_p.W795*	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	795					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TGGACTGGGCCCAGATTTTAA	0.537000													4	65					0	0	1	0	0
RTTN	25914	broad.mit.edu	37	18	67813011	67813011	+	Missense_Mutation	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr18:67813011G>A	ENST00000255674.6	-	18	2604	c.2318C>T	c.(2317-2319)tCg>tTg	p.S773L	RTTN_ENST00000437017.1_Missense_Mutation_p.S773L|RTTN_ENST00000454359.1_Missense_Mutation_p.S773L	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	773							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				TAATGCTAGCGAACGGACCCT	0.383000													18	88					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30374836	30374836	+	Missense_Mutation	SNP	C	C	T			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:30374836C>T	ENST00000327564.7	+	9	2441	c.2380C>T	c.(2380-2382)Cgg>Tgg	p.R794W	LRRC37B_ENST00000584368.1_Missense_Mutation_p.R728W|LRRC37B_ENST00000341671.7_Missense_Mutation_p.R767W|LRRC37B_ENST00000394713.3_Missense_Mutation_p.R716W|LRRC37B_ENST00000543378.2_Missense_Mutation_p.R685W			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	767						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				GTTACAAGCCCGGAAGCAGCA	0.493000													10	191					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29185216	29185216	+	Missense_Mutation	SNP	G	G	C			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr17:29185216G>C	ENST00000321990.4	+	9	3209	c.2831G>C	c.(2830-2832)aGa>aCa	p.R944T	CTD-2349P21.11_ENST00000580873.1_RNA	NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	944					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GAAGAAGTAAGAAATCTTTTG	0.303000													3	41					0	0	1	0	0
CTSC	1075	broad.mit.edu	37	11	88045588	88045588	+	Silent	SNP	G	G	A			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr11:88045588G>A	ENST00000227266.5	-	3	567	c.453C>T	c.(451-453)gtC>gtT	p.V151V		NM_001814.4	NP_001805.3	P53634	CATC_HUMAN	cathepsin C	151					immune response	lysosome	cysteine-type endopeptidase activity			large_intestine(7)|lung(8)|ovary(2)|prostate(3)|skin(2)	22		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GTGCTATGTTGACATACACAT	0.418000													33	118					0	0	1	0	0
PRKD2	25865	broad.mit.edu	37	19	47204144	47204144	+	Missense_Mutation	SNP	C	C	G			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr19:47204144C>G	ENST00000433867.1	-	8	1510	c.1033G>C	c.(1033-1035)Gag>Cag	p.E345Q	PRKD2_ENST00000601806.1_Missense_Mutation_p.E188Q|PRKD2_ENST00000600194.1_Missense_Mutation_p.E188Q|PRKD2_ENST00000595515.1_Missense_Mutation_p.E345Q|PRKD2_ENST00000291281.4_Missense_Mutation_p.E345Q	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349.1|NP_001073350.1|NP_057541.2	Q9BZL6	KPCD2_HUMAN	protein kinase D2	345					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		CCGGAGTCCTCTGACTCATCC	0.617000													9	48					0	0	1	0	0
WASF2	10163	broad.mit.edu	37	1	27744825	27744825	+	Frame_Shift_Del	DEL	C	C	-	rs150650907	byFrequency	TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr1:27744825delC	ENST00000430629.2	-	4	579	c.364delG	c.(364-366)aafs	p.E122fs	WASF2_ENST00000536657.1_Frame_Shift_Del_p.E122fs	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	122					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		TTGTATGTTTCTAAGACAGGC	0.443													12	69	---	---	---	---					
RAB2A	5862	broad.mit.edu	37	8	61533317	61533317	+	Frame_Shift_Del	DEL	G	G	-			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr8:61533317delG	ENST00000262646.7	+	8	979	c.628delG	c.(628-630)gcfs	p.G210fs	RAB2A_ENST00000531289.1_Frame_Shift_Del_p.G186fs|RAB2A_ENST00000529579.1_Frame_Shift_Del_p.A174fs|RAB2A_ENST00000530071.1_3'UTR	NM_002865.2	NP_002856.1	P61019	RAB2A_HUMAN	RAB2A, member RAS oncogene family	210					ER to Golgi vesicle-mediated transport|protein transport|small GTPase mediated signal transduction	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|melanosome	GDP binding|GTP binding|GTPase activity			endometrium(1)|large_intestine(1)|lung(4)	6			BRCA - Breast invasive adenocarcinoma(89;0.0805)			GGCTGGGGGCGGCTGCTGTTG	0.502													15	62	---	---	---	---					
FAS	355	broad.mit.edu	37	10	90768732	90768732	+	Frame_Shift_Del	DEL	G	G	-			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr10:90768732delG	ENST00000355740.2	+	4	641	c.421delG	c.(421-423)aafs	p.E141fs	FAS_ENST00000313771.5_3'UTR|FAS_ENST00000352159.4_Frame_Shift_Del_p.E141fs|FAS_ENST00000355279.2_Frame_Shift_Del_p.E141fs|FAS_ENST00000357339.2_Frame_Shift_Del_p.E141fs	NM_000043.4|NM_152871.2|NM_152872.2	NP_000034.1|NP_690610.1|NP_690611.1	P25445	TNR6_HUMAN	Fas cell surface death receptor	141					activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			breast(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		TACTGTATGTGAACACTGTGA	0.373													120	358	---	---	---	---					
SOCS6	9306	broad.mit.edu	37	18	67992094	67992094	+	Frame_Shift_Del	DEL	G	G	-			TCGA-KU-A6H7-01A-11D-A31L-08	TCGA-KU-A6H7-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07ebbb32-dc51-4e25-8421-af04946f07f9	51779779-e52a-4a47-b1ac-03447fdf0fbf	g.chr18:67992094delG	ENST00000397942.3	+	2	506	c.190delG	c.(190-192)gafs	p.G64fs	SOCS6_ENST00000582322.1_Frame_Shift_Del_p.G64fs	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	64					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				TGAAAAAGGCGGAAAAAACAG	0.468													18	82	---	---	---	---					
