Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	NBPF10_ENST00000369339.2_Silent_p.L113L|RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Silent_p.L113L	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													5	227					0	0	1	0	0
RTDR1	27156	broad.mit.edu	37	22	23401715	23401715	+	Silent	SNP	G	G	A	rs149525500		TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr22:23401715G>A	ENST00000216036.4	-	7	1168	c.972C>T	c.(970-972)taC>taT	p.Y324Y		NM_014433.2	NP_055248.1	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region gene 1	324							binding	p.Y324Y(1)		breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	18	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		GAGGCTTTTCGTAAGTCTCCA	0.607000													97	117					0	0	1	0	0
ANKS3	124401	broad.mit.edu	37	16	4764124	4764124	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr16:4764124C>T	ENST00000304283.4	-	7	931	c.637G>A	c.(637-639)Gga>Aga	p.G213R	ANKS3_ENST00000450067.2_Missense_Mutation_p.G7R|ANKS3_ENST00000446014.2_Missense_Mutation_p.G84R|ANKS3_ENST00000585773.1_Missense_Mutation_p.G140R	NM_133450.3	NP_597707.1	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain containing 3	213										endometrium(5)|kidney(4)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	19						TTCATGTGTCCGTACTGCTTG	0.622000													6	137					0	0	1	0	0
DCUN1D5	84259	broad.mit.edu	37	11	102954040	102954040	+	Missense_Mutation	SNP	A	A	C			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr11:102954040A>C	ENST00000260247.5	-	3	536	c.194T>G	c.(193-195)gTa>gGa	p.V65G	DCUN1D5_ENST00000531543.1_Intron	NM_032299.3	NP_115675.1	Q9BTE7	DCNL5_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 5	65	DCUN1.									NS(1)|central_nervous_system(1)|endometrium(2)	4		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.00032)|Epithelial(105;0.0689)|all cancers(92;0.186)		TTCTGGCCCTACAACTTCATC	0.323000													3	35					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578272	7578272	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr17:7578272G>A	ENST00000420246.2	-	6	709	c.577C>T	c.(577-579)Cat>Tat	p.H193Y	TP53_ENST00000413465.2_Missense_Mutation_p.H193Y|TP53_ENST00000455263.2_Missense_Mutation_p.H193Y|TP53_ENST00000359597.4_Missense_Mutation_p.H193Y|TP53_ENST00000269305.4_Missense_Mutation_p.H193Y|TP53_ENST00000445888.2_Missense_Mutation_p.H193Y|TP53_ENST00000574684.1_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	193	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193Y(29)|p.H193D(13)|p.0?(8)|p.?(6)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.P191_E198>Q(3)|p.P191fs*53(2)|p.H61D(2)|p.H100D(2)|p.P191fs*15(1)|p.H61Y(1)|p.P191fs*6(1)|p.H100Y(1)|p.P98_E105>Q(1)|p.H193_I195delHLI(1)|p.P59_E66>Q(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGATAAGATGCTGAGGAGGG	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			33	34					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	985004	985004	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:985004G>A	ENST00000379370.2	+	26	4623	c.4573G>A	c.(4573-4575)Gtc>Atc	p.V1525I		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	1525	Laminin G-like 1.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		TTTGCTGGACGTCAACAACCA	0.721000													3	12					0	0	1	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819554	50819554	+	Silent	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr10:50819554G>A	ENST00000374115.3	+	1	1208	c.768G>A	c.(766-768)gcG>gcA	p.A256A	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	256					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						TCTTTGACGCGCTGTTGCTGC	0.662000													12	40					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23701496	23701496	+	Silent	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr9:23701496G>A	ENST00000397312.2	-	5	868	c.594C>T	c.(592-594)atC>atT	p.I198I	ELAVL2_ENST00000380117.1_Silent_p.I198I|ELAVL2_ENST00000380110.4_Silent_p.I227I|ELAVL2_ENST00000223951.6_Silent_p.I198I|ELAVL2_ENST00000544538.1_Silent_p.I198I	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	198	RRM 2.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		ACTTTACAGTGATTGGCTCCG	0.488000													41	141					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1608001	1608001	+	Silent	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr16:1608001G>A	ENST00000426508.2	-	19	2697	c.2334C>T	c.(2332-2334)caC>caT	p.H778H	IFT140_ENST00000439987.2_5'UTR	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	778										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				AGAAGCTGAAGTGGAGCATGG	0.567000													35	153					0	0	1	0	0
TJAP1	93643	broad.mit.edu	37	6	43469298	43469298	+	Missense_Mutation	SNP	C	C	T	rs149220687		TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr6:43469298C>T	ENST00000372444.2	+	7	596	c.163C>T	c.(163-165)Cgc>Tgc	p.R55C	TJAP1_ENST00000438588.2_Missense_Mutation_p.R55C|TJAP1_ENST00000372445.5_Missense_Mutation_p.R55C|TJAP1_ENST00000372449.1_Missense_Mutation_p.R55C|TJAP1_ENST00000483640.1_3'UTR|TJAP1_ENST00000436109.2_Missense_Mutation_p.R55C|TJAP1_ENST00000372452.1_Missense_Mutation_p.R55C|TJAP1_ENST00000259751.1_Missense_Mutation_p.R55C	NM_001146018.1	NP_001139490.1	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 (peripheral)	55						Golgi apparatus|tight junction	protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|urinary_tract(2)	21	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GCTTCGCCGGCGCCTGGCCTC	0.632000													14	75					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11575545	11575545	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:11575545G>A	ENST00000294484.6	+	5	1711	c.1573G>A	c.(1573-1575)Gtg>Atg	p.V525M	PTCHD2_ENST00000389575.3_Missense_Mutation_p.V525M	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	525	SSD.				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GGCCGCCTTCGTGATCGTGGG	0.587000													15	72					0	0	1	0	0
RAPH1	65059	broad.mit.edu	37	2	204306114	204306114	+	Missense_Mutation	SNP	C	C	T	rs76891512		TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr2:204306114C>T	ENST00000319170.5	-	14	2098	c.1799G>A	c.(1798-1800)cGg>cAg	p.R600Q	RAPH1_ENST00000374493.3_Missense_Mutation_p.R652Q|RAPH1_ENST00000457812.1_Intron	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	600					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						AGTGTAGGGCCGATTCATAGA	0.483000													11	48					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158583611	158583611	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:158583611G>A	ENST00000368148.3	-	50	7069	c.6889C>T	c.(6889-6891)Cgg>Tgg	p.R2297W	SPTA1_ENST00000368147.3_Missense_Mutation_p.R2294W	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2297	EF-hand 1.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AGGCAGGACCGGAACTCTTTG	0.433000													14	28					0	0	1	0	0
YTHDF3	253943	broad.mit.edu	37	8	64100088	64100088	+	Missense_Mutation	SNP	T	T	G			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr8:64100088T>G	ENST00000539294.1	+	4	1832	c.1516T>G	c.(1516-1518)Ttt>Gtt	p.F506V	YTHDF3_ENST00000542911.2_Missense_Mutation_p.F317V|YTHDF3_ENST00000521674.1_3'UTR|YTHDF3_ENST00000517371.1_Intron	NM_001277817.1|NM_001277818.1|NM_152758.4	NP_001264746.1|NP_001264747.1|NP_689971.4	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	507	YTH.											Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			TAAATGGATCTTTGTCAAAGA	0.413000													5	49					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84607540	84607540	+	Missense_Mutation	SNP	A	A	C			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr9:84607540A>C	ENST00000344803.2	+	4	2202	c.2155A>C	c.(2155-2157)Att>Ctt	p.I719L		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		TCAGAGCAAAATTTCAGAGCT	0.478000													4	58					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56443608	56443608	+	Missense_Mutation	SNP	G	G	C	rs142099336		TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr19:56443608G>C	ENST00000588751.1	-	1	94	c.70C>G	c.(70-72)Ctg>Gtg	p.L24V	NLRP13_ENST00000342929.3_Missense_Mutation_p.L24V			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	24	DAPIN.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TACTGATCCAGGGCCATCAGG	0.552000													14	99					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112991	248112991	+	Missense_Mutation	SNP	A	A	C			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:248112991A>C	ENST00000357191.3	+	1	832	c.832A>C	c.(832-834)Acc>Ccc	p.T278P	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	278					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TGTCTTCTACACCATCCTCAC	0.493000													21	123					0	0	1	0	0
OR51F1	256892	broad.mit.edu	37	11	4790345	4790345	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr11:4790345C>T	ENST00000380383.1	-	1	823	c.824G>A	c.(823-825)cGg>cAg	p.R275Q	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron|OR51F1_ENST00000343430.3_Missense_Mutation_p.R268Q			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	268						integral to membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		GGGGGCTGACCGACCATAGCG	0.493000													10	82					0	0	1	0	0
ABCB9	23457	broad.mit.edu	37	12	123434439	123434439	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr12:123434439C>T	ENST00000542678.1	-	4	3581	c.743G>A	c.(742-744)gGc>gAc	p.G248D	ABCB9_ENST00000540285.1_Missense_Mutation_p.G248D|ABCB9_ENST00000442028.2_Missense_Mutation_p.G248D|ABCB9_ENST00000392439.3_Missense_Mutation_p.G248D|ABCB9_ENST00000280560.8_Missense_Mutation_p.G248D|ABCB9_ENST00000346530.5_Missense_Mutation_p.G248D|ABCB9_ENST00000344275.7_Missense_Mutation_p.G248D|ABCB9_ENST00000442833.2_Missense_Mutation_p.G248D			Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 9	248	ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		GGTAAAAATGCCGCCCCGAAT	0.522000													5	226					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60377361	60377361	+	Missense_Mutation	SNP	A	A	C			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:60377361A>C	ENST00000371204.3	-	4	646	c.603T>G	c.(601-603)ttT>ttG	p.F201L	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	201					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					CCTGGTACTCAAAGCGTTCTC	0.468000													24	105					0	0	1	0	0
KRT14	3861	broad.mit.edu	37	17	39742589	39742589	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr17:39742589G>T	ENST00000167586.6	-	1	584	c.498C>A	c.(496-498)ttC>ttA	p.F166L		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	166	Linker 1.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				CAATGGTCTTGAAGTAGGGAC	0.572000													15	168					3.27435e-08	3.5363e-08	1	1	0
OR2B6	26212	broad.mit.edu	37	6	27925800	27925800	+	Missense_Mutation	SNP	A	A	C			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr6:27925800A>C	ENST00000244623.1	+	1	782	c.782A>C	c.(781-783)cAa>cCa	p.Q261P		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GTGTACCTGCAACCACCTTCG	0.448000													21	116					0	0	1	0	0
STOML1	9399	broad.mit.edu	37	15	74281464	74281464	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr15:74281464G>T	ENST00000316900.5	-	3	499	c.375C>A	c.(373-375)aaC>aaA	p.N125K	STOML1_ENST00000359750.4_Missense_Mutation_p.N125K|STOML1_ENST00000561656.1_Missense_Mutation_p.N38K|STOML1_ENST00000564777.1_Intron|STOML1_ENST00000541638.1_Missense_Mutation_p.N83K|STOML1_ENST00000316911.6_Intron	NM_001256672.1|NM_001256675.1|NM_001256677.1|NM_004809.4	NP_001243601.1|NP_001243604.1|NP_001243606.1|NP_004800.2	Q9UBI4	STML1_HUMAN	stomatin (EPB72)-like 1	125						integral to membrane	sterol binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						AGGGAGGGACGTTGAAGGCTC	0.612000													18	69					1.64113e-05	1.73767e-05	1	1	0
INTS5	80789	broad.mit.edu	37	11	62416624	62416624	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr11:62416624G>A	ENST00000330574.2	-	2	980	c.928C>T	c.(928-930)Cga>Tga	p.R310*		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	310					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						AGCTCCCGTCGGATGCTATCT	0.622000													30	156					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	981638	981638	+	Silent	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:981638G>A	ENST00000379370.2	+	17	2954	c.2904G>A	c.(2902-2904)ccG>ccA	p.P968P		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	968	Kazal-like 9.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GCCTGGGCCCGTGCCAGGGTG	0.637000													24	113					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9063074	9063074	+	Nonsense_Mutation	SNP	C	C	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr5:9063074C>A	ENST00000382496.5	-	18	3108	c.2443G>T	c.(2443-2445)Gaa>Taa	p.E815*		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	815	TSP type-1 5.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						TACTTGGGTTCGGGGTTGTTG	0.562000													19	112					1.96292e-10	2.16322e-10	1	1	0
IGSF9B	22997	broad.mit.edu	37	11	133801985	133801985	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr11:133801985C>T	ENST00000321016.8	-	8	1321	c.1091G>A	c.(1090-1092)cGt>cAt	p.R364H	IGSF9B_ENST00000533871.2_Missense_Mutation_p.R364H			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	364	Ig-like 4.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTGCAGGGGACGGCCGTCCTT	0.607000													4	32					0	0	1	0	0
PRSS48	345062	broad.mit.edu	37	4	152203538	152203538	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr4:152203538G>A	ENST00000455694.2	+	3	456	c.454G>A	c.(454-456)Gga>Aga	p.G152R	SH3D19_ENST00000604030.1_Intron|PRSS48_ENST00000441586.2_Intron	NM_183375.2	NP_899231.2	Q7RTY5	PRS48_HUMAN	protease, serine, 48	152	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	8						TTGGGTGACCGGATGGGGAAA	0.463000													40	55					0	0	1	0	0
CPM	1368	broad.mit.edu	37	12	69260699	69260699	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr12:69260699T>C	ENST00000551568.1	-	7	977	c.917A>G	c.(916-918)gAa>gGa	p.E306G	CPM_ENST00000338356.3_Missense_Mutation_p.E306G|CPM_ENST00000546373.1_Missense_Mutation_p.E306G	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	306					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			CTTTATATATTCAATTAATGA	0.373000													9	51					0	0	1	0	0
OR8U1	219417	broad.mit.edu	37	11	56143908	56143908	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr11:56143908C>T	ENST00000302270.1	+	1	809	c.809C>T	c.(808-810)aCa>aTa	p.T270I		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					GCCCTGGACACAGACAAGATG	0.463000													5	176					0	0	1	0	0
RLN2	6019	broad.mit.edu	37	9	5304549	5304549	+	Missense_Mutation	SNP	C	C	T	rs2012109	byFrequency	TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr9:5304549C>T	ENST00000381627.3	-	1	420	c.32G>A	c.(31-33)gGa>gAa	p.G11E	RLN2_ENST00000308420.3_Missense_Mutation_p.G11E	NM_134441.2	NP_604390.1	P04090	REL2_HUMAN	relaxin 2	11					female pregnancy	extracellular region	hormone activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)	11	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.0987)		TAAACAGACTCCTAGCAGGTG	0.527000													7	119					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28228550	28228550	+	Missense_Mutation	SNP	T	T	G			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr15:28228550T>G	ENST00000354638.3	-	14	1599	c.1444A>C	c.(1444-1446)Act>Cct	p.T482P	OCA2_ENST00000382996.2_Missense_Mutation_p.T482P|OCA2_ENST00000353809.5_Missense_Mutation_p.T458P	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	482					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CCGATGGCAGTGGCAGCTCCT	0.478000									Oculocutaneous Albinism				12	74					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17446004	17446004	+	Silent	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr20:17446004G>A	ENST00000262545.2	+	11	1551	c.1236G>A	c.(1234-1236)ctG>ctA	p.L412L	PCSK2_ENST00000459871.1_3'UTR|PCSK2_ENST00000377899.1_Silent_p.L393L|PCSK2_ENST00000536609.1_Silent_p.L377L	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	412	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGCAGCATCTGACTGTGCTCA	0.592000													6	94					0	0	1	0	0
AGAP1	116987	broad.mit.edu	37	2	236957747	236957747	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr2:236957747G>A	ENST00000409538.1	+	15	3068	c.2572G>A	c.(2572-2574)Gaa>Aaa	p.E858K	AGAP1_ENST00000336665.5_Missense_Mutation_p.E593K|AGAP1_ENST00000428334.2_Missense_Mutation_p.E485K|AGAP1_ENST00000304032.7_Missense_Mutation_p.E646K			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	646					protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						CATGTGCATCGAATGCTCAGG	0.532000													16	112					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47588398	47588398	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr19:47588398C>T	ENST00000253048.5	-	8	1059	c.1022G>A	c.(1021-1023)cGg>cAg	p.R341Q	ZC3H4_ENST00000594019.1_5'UTR	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	341	Gly-rich.						nucleic acid binding|zinc ion binding	p.R341L(1)		NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GCCTCGGCCCCGACCCATTCC	0.627000													46	205					0	0	1	0	0
SLC25A43	203427	broad.mit.edu	37	X	118586106	118586106	+	Splice_Site	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chrX:118586106G>A	ENST00000217909.7	+	4	1169	c.825_splice	c.e4+1	p.K275_splice	SLC25A43_ENST00000488158.1_3'UTR|SLC25A43_ENST00000336249.7_Splice_Site_p.D218_splice	NM_145305.2	NP_660348.2	Q8WUT9	S2543_HUMAN	solute carrier family 25, member 43	275					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	9						ATTTACTGAAGGTGAGAAGAG	0.547000													8	84					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	119059214	119059214	+	Silent	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr4:119059214C>T	ENST00000296499.5	+	5	1633	c.1230C>T	c.(1228-1230)caC>caT	p.H410H	NDST3_ENST00000433996.2_Silent_p.H329H	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	410	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						CTTAGGAGCACGGCATTCCAA	0.418000													10	56					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176314638	176314638	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr5:176314638C>T	ENST00000292432.5	-	11	1505	c.1414G>A	c.(1414-1416)Gtg>Atg	p.V472M		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	472	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGGCAGCCACGGCAGTCACC	0.652000													14	60					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54672356	54672356	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr19:54672356G>A	ENST00000376591.4	-	4	642	c.511C>T	c.(511-513)Ctc>Ttc	p.L171F	TMC4_ENST00000476013.2_5'UTR|TMC4_ENST00000301187.4_Missense_Mutation_p.L165F	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	171						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TTAAGAAGGAGCAGGAAGCGC	0.672000											OREG0025670	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	12					0	0	1	0	0
DKKL1	27120	broad.mit.edu	37	19	49867984	49867984	+	Silent	SNP	C	C	G	rs141910577	by1000genomes	TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr19:49867984C>G	ENST00000221498.2	+	2	561	c.156C>G	c.(154-156)ctC>ctG	p.L52L	DKKL1_ENST00000594268.1_Intron	NM_014419.3	NP_055234.1	Q9UK85	DKKL1_HUMAN	dickkopf-like 1	52					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity			large_intestine(2)|upper_aerodigestive_tract(1)	3		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)		AGAGCCTACTCCAAGGCTTCA	0.572000													12	117					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7615195	7615195	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr19:7615195C>T	ENST00000221249.6	+	18	2140	c.1709C>T	c.(1708-1710)gCa>gTa	p.A570V	PNPLA6_ENST00000545201.2_Missense_Mutation_p.A544V|PNPLA6_ENST00000450331.3_Missense_Mutation_p.A570V|PNPLA6_ENST00000414982.3_Missense_Mutation_p.A618V|PNPLA6_ENST00000600737.1_Missense_Mutation_p.A609V|PNPLA6_ENST00000594864.1_3'UTR	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	609					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						ATCATGCGCGCACAGCCCAGT	0.632000													51	143					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351758	89351758	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr16:89351758C>T	ENST00000301030.4	-	9	1652	c.1192G>A	c.(1192-1194)Gca>Aca	p.A398T	ANKRD11_ENST00000378330.2_Missense_Mutation_p.A398T	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	398						nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTCTTTGGTGCAATCGTGTTA	0.453000													17	92					0	0	1	0	0
PARP4	143	broad.mit.edu	37	13	25021240	25021240	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr13:25021240C>T	ENST00000381989.3	-	26	3304	c.3199G>A	c.(3199-3201)Gag>Aag	p.E1067K		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1067					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		TGCAGGGCCTCGGGCACATCT	0.507000													6	94					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54968998	54968998	+	Missense_Mutation	SNP	G	G	A	rs143206355		TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr12:54968998G>A	ENST00000243052.3	+	11	1617	c.1181G>A	c.(1180-1182)cGt>cAt	p.R394H	PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000550620.1_Missense_Mutation_p.R374H|PDE1B_ENST00000538346.1_Missense_Mutation_p.R353H	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	394	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						GAATTCTTCCGTCAGGTAGCG	0.572000													6	81					0	0	1	0	0
DNAI2	64446	broad.mit.edu	37	17	72308160	72308160	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr17:72308160C>T	ENST00000579490.1	+	11	1819	c.1684C>T	c.(1684-1686)Cgg>Tgg	p.R562W	DNAI2_ENST00000311014.6_Missense_Mutation_p.R505W|DNAI2_ENST00000582036.1_Missense_Mutation_p.R493W|DNAI2_ENST00000307504.5_Missense_Mutation_p.R362W|DNAI2_ENST00000446837.2_Missense_Mutation_p.R505W			Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate chain 2	505					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GCGTGAGACCCGGCGAGAGAA	0.657000									Kartagener syndrome				8	50					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168315999	168315999	+	Silent	SNP	G	G	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr6:168315999G>T	ENST00000366806.2	+	18	2572	c.2430G>T	c.(2428-2430)ctG>ctT	p.L810L	MLLT4_ENST00000351017.4_Silent_p.L817L|MLLT4_ENST00000344191.4_Silent_p.L810L|MLLT4_ENST00000400822.3_Silent_p.L809L|MLLT4_ENST00000447894.2_Silent_p.L810L|MLLT4_ENST00000392112.1_Silent_p.L794L|MLLT4_ENST00000392108.3_Silent_p.L810L			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	810	Dilute.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		ATTCGGGGCTGTGCTCCCATT	0.547000			T	MLL	AL								5	55					0.014758	0.0148959	1	1	0
TEF	7008	broad.mit.edu	37	22	41791810	41791810	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr22:41791810C>T	ENST00000266304.4	+	4	874	c.758C>T	c.(757-759)gCc>gTc	p.A253V	TEF_ENST00000406644.3_Missense_Mutation_p.A223V	NM_003216.3	NP_003207.1	Q10587	TEF_HUMAN	thyrotrophic embryonic factor	253					rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)	6						TCACGGGATGCCCGGCGCCTG	0.582000													4	117					0	0	1	0	0
GALNT2	2590	broad.mit.edu	37	1	230415140	230415140	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:230415140G>A	ENST00000366672.4	+	16	1724	c.1652G>A	c.(1651-1653)aGc>aAc	p.S551N	GALNT2_ENST00000543760.1_Missense_Mutation_p.S513N|GALNT2_ENST00000485438.1_3'UTR	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	551	Ricin B-type lectin.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				GGGGGCCTAAGCGTGGAGGTG	0.637000													17	80					0	0	1	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973756	46973756	+	Silent	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr19:46973756G>A	ENST00000313683.10	-	2	842	c.537C>T	c.(535-537)gcC>gcT	p.A179A	PNMAL1_ENST00000602246.1_Intron|PNMAL1_ENST00000438932.2_Silent_p.A179A	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	179										cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		CGAATTCAGCGGCCTCCTGGG	0.612000													29	165					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32768426	32768426	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr2:32768426C>T	ENST00000421745.2	+	62	12544	c.12410C>T	c.(12409-12411)gCg>gTg	p.A4137V		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4137					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GAAACTGTTGCGGCTGAACCT	0.473000													52	220					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32280787	32280787	+	Missense_Mutation	SNP	C	C	T	rs34615674	byFrequency	TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:32280787C>T	ENST00000360482.2	-	2	277	c.148G>A	c.(148-150)Gga>Aga	p.G50R	SPOCD1_ENST00000257100.3_Intron|SPOCD1_ENST00000533231.1_Missense_Mutation_p.G50R|SPOCD1_ENST00000373648.2_Missense_Mutation_p.G50R	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	50					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		GCCCTGACTCCGGGCCCAGAG	0.637000													9	33					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4169591	4169591	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr7:4169591C>T	ENST00000404826.2	+	27	4130	c.3991C>T	c.(3991-3993)Cga>Tga	p.R1331*	SDK1_ENST00000389531.3_Nonsense_Mutation_p.R1331*	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1331	Fibronectin type-III 7.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCACATCGTGCGAGGGAACCA	0.652000													23	99					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37301542	37301542	+	Silent	SNP	A	A	G			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr5:37301542A>G	ENST00000231498.3	-	30	3761	c.3558T>C	c.(3556-3558)acT>acC	p.T1186T	NUP155_ENST00000381843.2_Silent_p.T1127T|NUP155_ENST00000513532.1_Silent_p.T1122T|NUP155_ENST00000502533.1_5'UTR	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	1186					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTATTACCTTAGTTATGTCCA	0.333000													11	92					0	0	1	0	0
BRAP	8315	broad.mit.edu	37	12	112098426	112098426	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr12:112098426C>T	ENST00000419234.4	-	7	1143	c.950G>A	c.(949-951)tGt>tAt	p.C317Y	BRAP_ENST00000327551.6_Missense_Mutation_p.C287Y|BRAP_ENST00000539060.1_Missense_Mutation_p.C138Y	NM_006768.3	NP_006759.3	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	317					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	20						ACACTCAAAACACTTATTTTC	0.403000													19	130					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237174	140237174	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr5:140237174G>A	ENST00000307360.5	+	1	1541	c.1541G>A	c.(1540-1542)gGc>gAc	p.G514D	PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.G514D|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGAGAGCGGCAAGGTGTAC	0.697000													48	191					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4091385	4091385	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr7:4091385T>A	ENST00000404826.2	+	19	2973	c.2834T>A	c.(2833-2835)tTc>tAc	p.F945Y	SDK1_ENST00000389531.3_Missense_Mutation_p.F945Y	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	945	Fibronectin type-III 3.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACCGCCTACTTCACTTCCGTT	0.562000													24	157					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940786	144940786	+	Silent	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr8:144940786C>T	ENST00000525985.1	-	2	6707	c.6636G>A	c.(6634-6636)gaG>gaA	p.E2212E				P58107	EPIPL_HUMAN	epiplakin 1	2212						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGCGGTCGTCCTCCATGAGCT	0.622000													38	282					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44974862	44974862	+	Silent	SNP	T	T	C			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr14:44974862T>C	ENST00000340446.4	-	1	1620	c.1329A>G	c.(1327-1329)tcA>tcG	p.S443S		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	443						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		CCATAGCTGTTGAAAGCTGAA	0.488000													3	30					0	0	1	0	0
TNS4	84951	broad.mit.edu	37	17	38645178	38645178	+	Silent	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr17:38645178G>A	ENST00000254051.6	-	3	641	c.483C>T	c.(481-483)caC>caT	p.H161H		NM_032865.5	NP_116254.4	Q8IZW8	TENS4_HUMAN	tensin 4	161					apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	30		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GGGGGCCATCGTGGCACCTTG	0.592000													46	52					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140742042	140742042	+	Silent	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr5:140742042C>T	ENST00000522605.1	+	1	2340	c.2340C>T	c.(2338-2340)ctC>ctT	p.L780L	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCAAGATCTCGTCTGTGACA	0.443000													16	104					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169433253	169433253	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr4:169433253C>T	ENST00000261509.6	+	2	809	c.598C>T	c.(598-600)Cca>Tca	p.P200S	PALLD_ENST00000505667.1_Missense_Mutation_p.P200S|PALLD_ENST00000333488.4_Missense_Mutation_p.P77S|PALLD_ENST00000335742.7_5'UTR	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	200					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GTCCTCGTCACCAGACAGTGG	0.512000									Pancreatic Cancer, Familial Clustering of				6	272					0	0	1	0	0
OR7A5	26659	broad.mit.edu	37	19	14938849	14938849	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr19:14938849C>A	ENST00000322301.3	-	2	292	c.205G>T	c.(205-207)Gct>Tct	p.A69S	OR7A5_ENST00000594432.1_Missense_Mutation_p.A69S|OR7A5_ENST00000601611.1_Intron			Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A, member 5	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26						CAAATGTCAGCAAAGGACAGG	0.498000													6	173					0.00307968	0.00313779	1	1	0
RHD	6007	broad.mit.edu	37	1	25627441	25627441	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:25627441A>G	ENST00000328664.4	+	4	646	c.491A>G	c.(490-492)gAc>gGc	p.D164G	RHD_ENST00000423810.2_Missense_Mutation_p.D164G|RHD_ENST00000454452.2_Missense_Mutation_p.D164G|RHD_ENST00000423253.1_3'UTR|RHD_ENST00000357542.4_Missense_Mutation_p.D164G|RHD_ENST00000342055.5_Missense_Mutation_p.D164G|RHD_ENST00000568195.1_Missense_Mutation_p.D164G|RHD_ENST00000417538.2_Missense_Mutation_p.D164G	NM_016124.3	NP_057208.2	Q02161	RHD_HUMAN	Rh blood group, D antigen	164						integral to plasma membrane				breast(2)|large_intestine(4)|lung(7)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TTGCAGACAGACTACCACATG	0.532000													23	145					0	0	1	0	0
SLC9C1	285335	broad.mit.edu	37	3	111923180	111923180	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr3:111923180C>A	ENST00000305815.5	-	17	2309	c.2057G>T	c.(2056-2058)gGc>gTc	p.G686V	SLC9C1_ENST00000487372.1_Missense_Mutation_p.G638V	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	686					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										ATGTAAGATGCCAATTAATGT	0.279000													6	47					0.0381472	0.0381472	1	1	0
C1orf112	55732	broad.mit.edu	37	1	169773286	169773286	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:169773286C>A	ENST00000286031.6	+	6	1083	c.383C>A	c.(382-384)gCc>gAc	p.A128D	C1orf112_ENST00000456684.1_Missense_Mutation_p.A186D|C1orf112_ENST00000359326.4_Missense_Mutation_p.A128D|C1orf112_ENST00000413811.2_Missense_Mutation_p.A99D|C1orf112_ENST00000498289.1_3'UTR	NM_018186.2	NP_060656.2	Q9NSG2	CA112_HUMAN	chromosome 1 open reading frame 112	128										breast(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|stomach(1)	34	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTCAAGGAGGCCTATTCTCTT	0.378000													7	72					0.00307968	0.00313779	1	1	0
ZNF497	162968	broad.mit.edu	37	19	58868531	58868531	+	Silent	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr19:58868531G>A	ENST00000311044.3	-	3	659	c.471C>T	c.(469-471)agC>agT	p.S157S	ZNF497_ENST00000425453.3_Silent_p.S157S|CTD-2619J13.8_ENST00000599109.1_RNA	NM_198458.2	NP_940860.2	Q6ZNH5	ZN497_HUMAN	zinc finger protein 497	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|lung(3)|skin(2)	7		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0278)		GCTTCTCGCCGCTGTGGATGC	0.672000													5	61					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101815931	101815931	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr5:101815931G>T	ENST00000506729.1	-	2	737	c.566C>A	c.(565-567)gCt>gAt	p.A189D	SLCO6A1_ENST00000379810.1_Missense_Mutation_p.A189D|SLCO6A1_ENST00000514551.1_Intron|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.A189D|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.A189D|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.A189D			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	189						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		GGATGGAAAAGCACATAAAAG	0.308000													9	44					1.12685e-05	1.20495e-05	1	1	0
TMEM168	64418	broad.mit.edu	37	7	112423832	112423832	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr7:112423832C>T	ENST00000312814.5	-	2	1609	c.1049G>A	c.(1048-1050)cGc>cAc	p.R350H	TMEM168_ENST00000454074.1_Missense_Mutation_p.R350H	NM_022484.4	NP_071929.3	Q9H0V1	TM168_HUMAN	transmembrane protein 168	350						integral to membrane|transport vesicle				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|stomach(1)	32						GCAAAAATGGCGCATCCCTTT	0.408000													31	159					0	0	1	0	0
TRIM36	55521	broad.mit.edu	37	5	114515698	114515698	+	Missense_Mutation	SNP	T	T	G			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr5:114515698T>G	ENST00000282369.3	-	1	158	c.37A>C	c.(37-39)Atc>Ctc	p.I13L	TRIM36_ENST00000379618.2_Missense_Mutation_p.I13L|TRIM36_ENST00000514154.1_5'UTR|TRIM36_ENST00000379617.2_Missense_Mutation_p.I13L	NM_018700.3	NP_061170.2	Q9NQ86	TRI36_HUMAN	tripartite motif containing 36	13						acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			breast(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	37		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		AATTCCATGATGTAGCCAAAT	0.572000													12	112					0	0	1	0	0
ZNF470	388566	broad.mit.edu	37	19	57089268	57089268	+	Missense_Mutation	SNP	C	C	T	rs143920172	byFrequency	TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr19:57089268C>T	ENST00000330619.8	+	6	2157	c.1471C>T	c.(1471-1473)Cgg>Tgg	p.R491W	ZNF470_ENST00000601902.1_Intron|ZNF470_ENST00000391709.3_Missense_Mutation_p.R491W	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	491					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R491W(1)		endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		GAAAGCTTTCCGGCAGAGCAC	0.453000													34	68					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40321521	40321521	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr17:40321521C>T	ENST00000264661.3	-	9	1896	c.1564G>A	c.(1564-1566)Gtc>Atc	p.V522I	KCNH4_ENST00000607371.1_Missense_Mutation_p.V522I	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	522					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity	p.V522I(1)		autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCGCTGTTGACGGCCCACGTG	0.652000													13	68					0	0	1	0	0
TXNDC16	57544	broad.mit.edu	37	14	52985898	52985898	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr14:52985898C>T	ENST00000281741.4	-	7	877	c.506G>A	c.(505-507)gGa>gAa	p.G169E	TXNDC16_ENST00000554399.1_Intron	NM_001160047.1|NM_020784.2	NP_001153519.1|NP_065835.2	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16	169					cell redox homeostasis	extracellular region				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(3)|skin(1)	21	Breast(41;0.0716)					ACCTGGTATTCCAATGGCTCT	0.323000													7	31					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67333330	67333330	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr16:67333330C>T	ENST00000304372.5	-	6	977	c.922G>A	c.(922-924)Gag>Aag	p.E308K	KCTD19_ENST00000562860.1_5'UTR	NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	308						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		AGCGTGCTCTCGATGCGAAGC	0.607000													26	123					0	0	1	0	0
THOP1	7064	broad.mit.edu	37	19	2805086	2805086	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr19:2805086A>G	ENST00000307741.6	+	6	865	c.662A>G	c.(661-663)tAc>tGc	p.Y221C	THOP1_ENST00000586677.1_Missense_Mutation_p.Y100C	NM_003249.3	NP_003240.1	P52888	THOP1_HUMAN	thimet oligopeptidase 1	221					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|lung(8)|ovary(2)|skin(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCCTCAAGTACCCCCATTAC	0.577000													7	39					0	0	1	0	0
OR6C65	403282	broad.mit.edu	37	12	55795015	55795015	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr12:55795015G>T	ENST00000379665.2	+	1	802	c.703G>T	c.(703-705)Gct>Tct	p.A235S		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						AAGGAAAAAGGCTTTTTCAAC	0.393000													26	69					4.26978e-12	4.75398e-12	1	1	0
POM121L9P	29774	broad.mit.edu	37	22	24656959	24656959	+	RNA	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr22:24656959G>A	ENST00000414583.2	+	0	2032					NR_003714.1																						CCTCAGGGAGGGAGTGACCTC	0.627000													4	4					0	0	1	0	0
CLDN10	9071	broad.mit.edu	37	13	96212437	96212437	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr13:96212437T>C	ENST00000376873.3	+	2	496	c.266T>C	c.(265-267)tTc>tCc	p.F89S	CLDN10_ENST00000299339.2_Missense_Mutation_p.F91S|CLDN10_ENST00000376855.1_Missense_Mutation_p.F9S	NM_001160100.1|NM_182848.3	NP_001153572.1|NP_878268.1	P78369	CLD10_HUMAN	claudin 10	91					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			AGCCTGGGCTTCTTTGGTTCC	0.438000													16	58					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196658607	196658607	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:196658607G>A	ENST00000367429.4	+	8	1262	c.1022G>A	c.(1021-1023)cGt>cAt	p.R341H	CFH_ENST00000359637.2_Missense_Mutation_p.R277H|CFH_ENST00000439155.2_Missense_Mutation_p.R341H	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	341	Sushi 6.				complement activation, alternative pathway	extracellular space		p.R341H(2)		NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						GAGAATATGCGTAGACCATAC	0.333000													10	60					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23510065	23510065	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr5:23510065G>A	ENST00000296682.3	+	4	412	c.230G>A	c.(229-231)cGa>cAa	p.R77Q		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	77	KRAB-related.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						ATGTGTCACCGAAGGCAGGCC	0.468000										HNSCC(3;0.000094)			8	98					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83758445	83758445	+	Silent	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr7:83758445G>A	ENST00000265362.3	-	3	641	c.327C>T	c.(325-327)gaC>gaT	p.D109D	SEMA3A_ENST00000436949.1_Silent_p.D109D	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	109	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						TTACCAGGATGTCTTTTCCAG	0.353000													13	71					0	0	1	0	0
NAT8	9027	broad.mit.edu	37	2	73868607	73868607	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr2:73868607G>A	ENST00000272425.3	-	2	298	c.149C>T	c.(148-150)cCc>cTc	p.P50L		NM_003960.3|NM_016347.2	NP_003951.3|NP_057431.2	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8 (GCN5-related, putative)	50					gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			breast(1)|endometrium(2)|kidney(2)|lung(2)|ovary(1)|prostate(1)	9						TAGGGCGAGGGGCCCCCCAAG	0.612000													26	49					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62910180	62910180	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr4:62910180C>T	ENST00000512091.1	+	24	4270	c.3523C>T	c.(3523-3525)Cgt>Tgt	p.R1175C	LPHN3_ENST00000507625.1_Missense_Mutation_p.R1234C|LPHN3_ENST00000507164.1_Missense_Mutation_p.R1234C|LPHN3_ENST00000509896.1_Missense_Mutation_p.R1243C|LPHN3_ENST00000506746.1_Missense_Mutation_p.R1234C|LPHN3_ENST00000504896.1_Missense_Mutation_p.R1175C|LPHN3_ENST00000511324.1_Missense_Mutation_p.R1234C|LPHN3_ENST00000508693.1_Missense_Mutation_p.R1243C|LPHN3_ENST00000508946.1_Missense_Mutation_p.R1175C|LPHN3_ENST00000506720.1_Missense_Mutation_p.R1243C|LPHN3_ENST00000514996.1_Missense_Mutation_p.R1166C|LPHN3_ENST00000545650.1_Missense_Mutation_p.R1175C|LPHN3_ENST00000506700.1_Missense_Mutation_p.R1166C|LPHN3_ENST00000514157.1_Missense_Mutation_p.R1166C|LPHN3_ENST00000514591.1_Missense_Mutation_p.R1175C			Q9HAR2	LPHN3_HUMAN	latrophilin 3	1153					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						GAGCCGAATCCGTAGAATGTG	0.388000													6	10					0	0	1	0	0
FCGR1B	2210	broad.mit.edu	37	1	120927141	120927141	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr1:120927141G>A	ENST00000369384.4	-	5	881	c.839C>T	c.(838-840)aCg>aTg	p.T280M	RP11-439A17.9_ENST00000457996.1_RNA|RP11-439A17.10_ENST00000426275.1_RNA|FCGR1B_ENST00000369383.4_Missense_Mutation_p.T188M	NM_001017986.3	NP_001017986.1	Q92637	FCGRB_HUMAN	Fc fragment of IgG, high affinity Ib, receptor (CD64)	280					interferon-gamma-mediated signaling pathway	integral to membrane|plasma membrane	IgG binding|immunoglobulin receptor activity			breast(1)|endometrium(1)|lung(2)	4	all_neural(166;0.181)	all_lung(203;7.27e-05)|Lung NSC(69;0.000389)|all_epithelial(167;0.068)		Lung(183;0.0327)|LUSC - Lung squamous cell carcinoma(189;0.19)		CCGCTGCTACGTGGCCCCCTG	0.542000													10	76					0	0	1	0	0
PEX12	5193	broad.mit.edu	37	17	33904241	33904241	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr17:33904241C>A	ENST00000225873.4	-	2	1103	c.496G>T	c.(496-498)Gtg>Ttg	p.V166L		NM_000286.2	NP_000277.1	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	166					protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(1)|lung(8)	18				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCCATGTTCACAAATGGGTAG	0.483000													34	31					8.53417e-09	9.31001e-09	1	1	0
CACNA1H	8912	broad.mit.edu	37	16	1257353	1257353	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr16:1257353G>A	ENST00000348261.5	+	14	3234	c.2986G>A	c.(2986-2988)Gtg>Atg	p.V996M	CACNA1H_ENST00000358590.4_Missense_Mutation_p.V996M|CACNA1H_ENST00000565831.1_Missense_Mutation_p.V996M	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	996					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CCTCTACTTCGTGGCCCTCAT	0.647000													4	22					0	0	1	0	0
PRKCA	5578	broad.mit.edu	37	17	64684445	64684445	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr17:64684445C>T	ENST00000413366.3	+	7	738	c.712C>T	c.(712-714)Cga>Tga	p.R238*		NM_002737.2	NP_002728.1	P17252	KPCA_HUMAN	protein kinase C, alpha	238	C2.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	AGACAAAGACCGACGACTGTC	0.448000													7	66					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218683176	218683176	+	Silent	SNP	A	A	G			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr2:218683176A>G	ENST00000171887.4	-	24	4019	c.3567T>C	c.(3565-3567)acT>acC	p.T1189T	TNS1_ENST00000430930.1_Silent_p.T1168T|TNS1_ENST00000419504.1_Silent_p.T1176T	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1189						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GACTAGGGGGAGTGTTGGTGC	0.647000													4	123					0	0	1	0	0
CABYR	26256	broad.mit.edu	37	18	21735867	21735867	+	Silent	SNP	G	G	C	rs144981165		TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr18:21735867G>C	ENST00000399481.2	+	2	260	c.108G>C	c.(106-108)acG>acC	p.T36T	CABYR_ENST00000581397.1_Silent_p.T134T|CABYR_ENST00000415309.2_Silent_p.T134T|CABYR_ENST00000399496.3_Silent_p.T134T|CABYR_ENST00000399499.1_Silent_p.T134T|CABYR_ENST00000327201.6_Silent_p.T36T			O75952	CABYR_HUMAN	calcium binding tyrosine-(Y)-phosphorylation regulated	134	RIIa.				ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)	11	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					CTGAGCAAACGGAAGCAGTTG	0.493000													19	82					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49710999	49710999	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr17:49710999G>A	ENST00000451037.2	-	8	1742	c.802C>T	c.(802-804)Cgc>Tgc	p.R268C	CA10_ENST00000570565.1_Missense_Mutation_p.R193C|CA10_ENST00000285273.4_Missense_Mutation_p.R268C|CA10_ENST00000340813.6_Missense_Mutation_p.R274C|CA10_ENST00000442502.2_Missense_Mutation_p.R268C	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	268					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			CTGAGCAGGCGCAAGGAATGC	0.512000													29	33					0	0	1	0	0
TRIM56	81844	broad.mit.edu	37	7	100732306	100732307	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr7:100732306_100732307delTC	ENST00000306085.6	+	3	2010_2011	c.1713_1714delTC	c.(1711-1716)tatcfs	p.YL571fs		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	571					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					CACGGCTCTATCTCATCAACCC	0.708													22	303	---	---	---	---					
CDKN2A	1029	broad.mit.edu	37	9	21974696	21974697	+	Frame_Shift_Ins	INS	-	-	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr9:21974696_21974697insA	ENST00000304494.5	-	1	400_401	c.130_131insT	c.(130-132)cggfs	p.R44fs	CDKN2A_ENST00000446177.1_Frame_Shift_Ins_p.R44fs|CDKN2A_ENST00000494262.1_Intron|CDKN2A_ENST00000579122.1_Frame_Shift_Ins_p.R44fs|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000530628.2_Intron|CDKN2A_ENST00000579755.1_Intron|CDKN2A_ENST00000498124.1_Frame_Shift_Ins_p.R44fs|CDKN2A_ENST00000361570.3_Intron|CDKN2A_ENST00000498628.2_Intron	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	44					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(25)|p.0(1)|p.V28_V51del(1)|p.Y44fs*76(1)|p.Y44S(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCTCCGACCGTAACTATTCGGT	0.688		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			43	199	---	---	---	---					
CDKN2A	1029	broad.mit.edu	37	9	21974725	21974742	+	In_Frame_Del	DEL	CGCCTCCAGCAGCGCCCG	CGCCTCCAGCAGCGCCCG	-			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr9:21974725_21974742delCGCCTCCAGCAGCGCCCG	ENST00000304494.5	-	1	355_372	c.85_102delCGGGCGCTGCTGGAGGCG	c.(85-102)del	p.RALLEA29del	CDKN2A_ENST00000446177.1_In_Frame_Del_p.RALLEA29del|CDKN2A_ENST00000494262.1_Intron|CDKN2A_ENST00000579122.1_In_Frame_Del_p.RALLEA29del|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000530628.2_Intron|CDKN2A_ENST00000579755.1_Intron|CDKN2A_ENST00000498124.1_In_Frame_Del_p.RALLEA29del|CDKN2A_ENST00000361570.3_Intron|CDKN2A_ENST00000498628.2_Intron	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	29					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(23)|p.L32_L37del(5)|p.A30V(3)|p.E33*(2)|p.A34V(2)|p.V28_E33del(2)|p.R29_A34del(2)|p.A30A(2)|p.G35fs*13(1)|p.R29Q(1)|p.0(1)|p.V28_V51del(1)|p.L32R(1)|p.R29fs*9(1)|p.L31P(1)|p.A34A(1)|p.E33fs*8(1)|p.A30P(1)|p.E33D(1)|p.A36fs*8(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCAGCGCCCCCGCCTCCAGCAGCGCCCGCACCTCCTCT	0.734		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			21	161	---	---	---	---					
LINC00475	158314	broad.mit.edu	37	9	94904432	94904432	+	RNA	DEL	G	G	-	rs58003635		TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr9:94904432delG	ENST00000416438.2	+	0	184					NR_027341.1																						GGCCTTCTTTGGGGGGGGGGT	0.612													5	6	---	---	---	---					
SLC43A3	29015	broad.mit.edu	37	11	57185305	57185308	+	Frame_Shift_Del	DEL	CAGA	CAGA	-			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr11:57185305_57185308delCAGA	ENST00000395123.2	-	8	888_891	c.584_587delTCTG	c.(583-588)gcfs	p.VC195fs	SLC43A3_ENST00000528098.1_5'UTR|SLC43A3_ENST00000529554.1_Frame_Shift_Del_p.VC195fs|SLC43A3_ENST00000352187.1_Frame_Shift_Del_p.VC195fs|SLC43A3_ENST00000533524.1_Frame_Shift_Del_p.VC208fs|SLC43A3_ENST00000395124.1_Frame_Shift_Del_p.VC195fs	NM_001278201.1|NM_014096.2	NP_001265130.1|NP_054815.2	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	195					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	27						CCAGGTACTGCAGACAGAGATGAA	0.525													9	88	---	---	---	---					
KRT5	3852	broad.mit.edu	37	12	52910505	52910506	+	Frame_Shift_Ins	INS	-	-	CA			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr12:52910505_52910506insCA	ENST00000252242.4	-	7	1744_1745	c.1354_1355insTG	c.(1354-1356)gtafs	p.V452fs		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	452	Coil 2.|Rod.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		CTCCTGGTACTCACGCAGCAGC	0.634													32	211	---	---	---	---					
INTS6-AS1	100507398	broad.mit.edu	37	13	52035523	52035524	+	RNA	INS	-	-	A			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr13:52035523_52035524insA	ENST00000594959.1	+	0	411				INTS6-AS1_ENST00000594358.1_RNA|INTS6-AS1_ENST00000593429.1_RNA|INTS6-AS1_ENST00000595435.1_RNA|INTS6-AS1_ENST00000594488.1_RNA|INTS6-AS1_ENST00000593709.1_RNA|INTS6-AS1_ENST00000600477.1_RNA|INTS6-AS1_ENST00000594604.1_RNA|INTS6-AS1_ENST00000599315.1_RNA|INTS6-AS1_ENST00000601034.1_RNA|INTS6-AS1_ENST00000596050.1_RNA|INTS6-AS1_ENST00000601318.1_RNA|INTS6-AS1_ENST00000596180.1_RNA|INTS6-AS1_ENST00000596303.1_RNA|INTS6-AS1_ENST00000593672.1_RNA|INTS6-AS1_ENST00000598864.1_RNA|INTS6-AS1_ENST00000593928.1_RNA|INTS6-AS1_ENST00000601572.1_RNA|INTS6-AS1_ENST00000597745.1_RNA|INTS6-AS1_ENST00000595424.1_RNA|INTS6-AS1_ENST00000595997.1_RNA|INTS6-AS1_ENST00000602089.1_RNA|INTS6-AS1_ENST00000434512.1_RNA																							AGCAAAAAAAGAAAAAAAAATC	0.361													2	4	---	---	---	---					
DDX27	55661	broad.mit.edu	37	20	47858504	47858504	+	Frame_Shift_Del	DEL	A	A	-			TCGA-P3-A5QA-01A-11D-A28R-08	TCGA-P3-A5QA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df5a650-5904-4922-a8f5-1b4a40a56943	88c181a4-5488-4095-be4e-f0553e6c66ee	g.chr20:47858504delA	ENST00000371764.4	+	17	2074	c.2065delA	c.(2065-2067)aafs	p.K691fs	DDX27_ENST00000484427.1_3'UTR|ZNFX1_ENST00000371754.4_Intron|ZNFX1_ENST00000469991.1_Intron	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	691						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding	p.K691fs*4(3)		NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GAAGGATGCCAAAAAAAAGGG	0.488													7	205	---	---	---	---					
