Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CASZ1	54897	broad.mit.edu	37	1	10720504	10720504	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:10720504C>T	ENST00000377022.3	-	6	912	c.595G>A	c.(595-597)Gag>Aag	p.E199K	CASZ1_ENST00000344008.5_Missense_Mutation_p.E199K	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CTGGCCAGCTCGTCCCGCGTG	0.637000													5	42					0	0	1	0	0
OSR1	130497	broad.mit.edu	37	2	19553234	19553234	+	Silent	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr2:19553234G>C	ENST00000536433.1	-	1	3443	c.333C>G	c.(331-333)ctC>ctG	p.L111L	OSR1_ENST00000272223.2_Silent_p.L111L			Q8TAX0	OSR1_HUMAN	odd-skipped related transciption factor 1	111					chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|heart development|mesangial cell development|mesonephric duct morphogenesis|metanephric cap mesenchymal cell proliferation involved in metanephros development|metanephric glomerulus vasculature development|metanephric interstitial cell development|metanephric mesenchymal cell differentiation|metanephric nephron tubule development|metanephric smooth muscle tissue development|middle ear morphogenesis|negative regulation of apoptosis|negative regulation of nephron tubule epithelial cell differentiation|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|pattern specification involved in metanephros development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of gastrulation|positive regulation of transcription from RNA polymerase II promoter|pronephros development|renal vesicle progenitor cell differentiation|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|stem cell differentiation|transcription, DNA-dependent|ureter urothelium development|ureteric bud development	nucleolus	nucleic acid binding|zinc ion binding			breast(1)|large_intestine(2)|lung(4)|ovary(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	Acute lymphoblastic leukemia(84;0.221)				GCTTGGTCTTGAGCGCTGGAA	0.637000													6	42					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17697666	17697666	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr17:17697666C>T	ENST00000353383.1	+	3	1873	c.1404C>T	c.(1402-1404)ctC>ctT	p.L468L	RAI1_ENST00000261641.6_Silent_p.L468L	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	468						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		TCAAGAACCTCGTGTCCAGGA	0.627000													5	64					0	0	1	0	0
RCBTB2	1102	broad.mit.edu	37	13	49073886	49073886	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr13:49073886A>G	ENST00000344532.3	-	13	1678	c.1255T>C	c.(1255-1257)Ttt>Ctt	p.F419L	RCBTB2_ENST00000544492.1_Missense_Mutation_p.F145L|RCBTB2_ENST00000430805.2_Missense_Mutation_p.F424L	NM_001268.2	NP_001259.1	O95199	RCBT2_HUMAN	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	419	BTB 1.						Ran guanyl-nucleotide exchange factor activity			breast(5)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(3)	31		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		GACGAACGAAAATGCTCACAT	0.458000													12	67					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269411	150269411	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr7:150269411G>C	ENST00000255945.2	+	3	428	c.253G>C	c.(253-255)Gac>Cac	p.D85H	GIMAP4_ENST00000461940.1_Missense_Mutation_p.D99H|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	85							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGTCGTAGTTGACACACCAGG	0.498000													3	54					0	0	1	0	0
AP1AR	55435	broad.mit.edu	37	4	113189405	113189405	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr4:113189405C>T	ENST00000274000.5	+	10	1104	c.749C>T	c.(748-750)tCa>tTa	p.S250L	AP1AR_ENST00000309703.6_Missense_Mutation_p.S217L	NM_018569.4	NP_061039.3	Q63HQ0	AP1AR_HUMAN	adaptor-related protein complex 1 associated regulatory protein	250					protein transport	early endosome|Golgi apparatus|late endosome|transport vesicle				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)	9						AATCCTACATCAGCCTCTGAT	0.403000													6	90					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152275878	152275878	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:152275878C>T	ENST00000368799.1	-	3	11519	c.11484G>A	c.(11482-11484)tcG>tcA	p.S3828S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3828	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGGTGACGCGACCCTGAGT	0.587000									Ichthyosis				41	504					0	0	1	0	0
IGKV1D-8	28904	broad.mit.edu	37	2	90260160	90260160	+	RNA	SNP	G	G	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr2:90260160G>T	ENST00000471857.1	+	0	444																											AGTGGCAGTGGATCTGGGACA	0.468000													33	178					3.90053e-15	4.10429e-15	1	1	0
VPS33B	26276	broad.mit.edu	37	15	91557626	91557626	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr15:91557626G>A	ENST00000333371.3	-	4	630	c.277C>T	c.(277-279)Cga>Tga	p.R93*	VPS33B_ENST00000557358.1_5'UTR|VPS33B_ENST00000535843.1_Nonsense_Mutation_p.R2*|VPS33B_ENST00000535906.1_Nonsense_Mutation_p.R66*	NM_018668.3	NP_061138.3	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33 homolog B (yeast)	93					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|stomach(2)	16	Lung NSC(78;0.0987)|all_lung(78;0.175)					GCAATGTATCGCATATTCTTG	0.418000													19	257					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175898456	175898456	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr4:175898456G>A	ENST00000359240.3	+	5	2450	c.1780G>A	c.(1780-1782)Gat>Aat	p.D594N	ADAM29_ENST00000404450.4_Missense_Mutation_p.D594N|ADAM29_ENST00000445694.1_Missense_Mutation_p.D594N|ADAM29_ENST00000514159.1_Missense_Mutation_p.D594N	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	594	Cys-rich.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GAAGGGACCTGATATTGGTGA	0.418000													12	202					0	0	1	0	0
CCDC144NL	339184	broad.mit.edu	37	17	20799296	20799296	+	Missense_Mutation	SNP	C	C	T	rs148155806	byFrequency	TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr17:20799296C>T	ENST00000327925.5	-	1	157	c.38G>A	c.(37-39)gGg>gAg	p.G13E	RP11-344E13.3_ENST00000583962.1_RNA|RP11-344E13.3_ENST00000439794.2_RNA|RP11-344E13.3_ENST00000582324.1_RNA|RP11-344E13.3_ENST00000577860.1_RNA|RP11-344E13.3_ENST00000577537.1_RNA|RP11-344E13.3_ENST00000417232.2_RNA	NM_001004306.1	NP_001004306.1	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family, N-terminal like	13										large_intestine(3)|lung(3)|skin(1)	7						CGGAGACCCCCCAGCCCCTCC	0.647000											OREG0024248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	8					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51773096	51773096	+	Silent	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr15:51773096G>A	ENST00000251076.5	-	24	6494	c.6207C>T	c.(6205-6207)ctC>ctT	p.L2069L	DMXL2_ENST00000543779.2_Silent_p.L2069L|DMXL2_ENST00000449909.3_Silent_p.L1433L|RP11-707P17.1_ENST00000561007.1_RNA	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2069						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		GTTGAAATCTGAGTTTTCCTC	0.333000													15	122					0	0	1	0	0
SYTL5	94122	broad.mit.edu	37	X	37955445	37955445	+	Silent	SNP	T	T	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chrX:37955445T>A	ENST00000357972.5	+	9	1566	c.1020T>A	c.(1018-1020)acT>acA	p.T340T	TM4SF2_ENST00000465127.1_Intron|SYTL5_ENST00000297875.2_Silent_p.T340T|SYTL5_ENST00000456733.2_Silent_p.T340T			Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5	340					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	44						CAGAGGATACTGTAAGCATAA	0.418000													30	49					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138643737	138643737	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chrX:138643737G>A	ENST00000218099.2	+	8	900	c.893G>A	c.(892-894)cGa>cAa	p.R298Q	F9_ENST00000394090.2_Missense_Mutation_p.R260Q	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	298	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	AATGTGATTCGAATTATTCCT	0.353000													11	37					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14813014	14813014	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr9:14813014G>A	ENST00000380881.4	-	17	3507	c.2692C>T	c.(2692-2694)Cct>Tct	p.P898S	FREM1_ENST00000422223.2_Missense_Mutation_p.P897S|FREM1_ENST00000380880.3_Missense_Mutation_p.P897S			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	897					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TTCATGACAGGCATGAGGTCA	0.413000													15	112					0	0	1	0	0
TSPYL5	85453	broad.mit.edu	37	8	98289558	98289558	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr8:98289558G>A	ENST00000322128.3	-	1	618	c.515C>T	c.(514-516)gCg>gTg	p.A172V		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	172					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					CTCCCCTGCCGCCCCTTTCTT	0.652000													6	101					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8341854	8341854	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr9:8341854C>A	ENST00000381196.4	-	37	5329	c.4786G>T	c.(4786-4788)Gtt>Ttt	p.V1596F	PTPRD_ENST00000486161.1_Missense_Mutation_p.V1189F|PTPRD_ENST00000358503.5_Missense_Mutation_p.V1574F|PTPRD_ENST00000355233.5_Missense_Mutation_p.V1190F|PTPRD_ENST00000360074.4_Missense_Mutation_p.V1583F|PTPRD_ENST00000540109.1_Missense_Mutation_p.V1596F|PTPRD_ENST00000537002.1_Missense_Mutation_p.V1186F|PTPRD_ENST00000397606.3_Missense_Mutation_p.V1189F|PTPRD_ENST00000356435.5_Missense_Mutation_p.V1596F|PTPRD_ENST00000397617.3_Missense_Mutation_p.V1189F|PTPRD_ENST00000397611.3_Missense_Mutation_p.V1186F	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1596	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCTGTTTGAACCATATAGTTC	0.378000										TSP Lung(15;0.13)			19	292					0.0383953	0.0383953	1	1	0
BOC	91653	broad.mit.edu	37	3	112993426	112993426	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:112993426C>T	ENST00000495514.1	+	9	2143	c.1439C>T	c.(1438-1440)tCg>tTg	p.S480L	BOC_ENST00000497495.1_3'UTR|BOC_ENST00000355385.3_Missense_Mutation_p.S480L|BOC_ENST00000273395.4_Missense_Mutation_p.S480L			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	480	Fibronectin type-III 1.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			ATCCTCAGCTCGCCCCGCACC	0.662000													6	80					0	0	1	0	0
KLHL25	64410	broad.mit.edu	37	15	86312316	86312316	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr15:86312316C>T	ENST00000337975.5	-	2	1000	c.726G>A	c.(724-726)ccG>ccA	p.P242P	KLHL25_ENST00000559131.1_Intron|KLHL25_ENST00000536947.1_Silent_p.P242P	NM_022480.3	NP_071925.2	Q9H0H3	ENC2_HUMAN	kelch-like family member 25	242						cytoplasm				breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	25						GGCAGTCGGACGGCAGCAAGG	0.652000													5	30					0	0	1	0	0
TREX1	11277	broad.mit.edu	37	3	48507918	48507918	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:48507918G>C	ENST00000422277.2	+	1	690	c.29G>C	c.(28-30)aGg>aCg	p.R10T	TREX1_ENST00000492235.1_Intron|TREX1_ENST00000456089.1_Intron|TREX1_ENST00000444177.1_Intron|TREX1_ENST00000433541.1_Intron|TREX1_ENST00000436480.2_Intron|TREX1_ENST00000296443.9_Intron	NM_016381.3	NP_057465.1	Q9NSU2	TREX1_HUMAN	three prime repair exonuclease 1	10					cell death|DNA recombination|DNA replication|mismatch repair	nuclear envelope	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|metal ion binding|MutLalpha complex binding|MutSalpha complex binding|protein homodimerization activity|single-stranded DNA binding			breast(1)|kidney(1)|large_intestine(1)|lung(3)|skin(3)	9				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		AGACAGGGCAGGATTGTGCAG	0.597000													7	52					0	0	1	0	0
TUFM	7284	broad.mit.edu	37	16	28854443	28854443	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr16:28854443C>T	ENST00000313511.3	-	10	1359	c.1221G>A	c.(1219-1221)ctG>ctA	p.L407L		NM_003321.4	NP_003312.3	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	404						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13						GGTTGAACTTCAGGTCCTCCC	0.537000													8	66					0	0	1	0	0
CAPZA2	830	broad.mit.edu	37	7	116546361	116546361	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr7:116546361C>T	ENST00000361183.2	+	6	610	c.471C>T	c.(469-471)tgC>tgT	p.C157C	CAPZA2_ENST00000458284.2_Intron	NM_006136.2	NP_006127.1	P47755	CAZA2_HUMAN	capping protein (actin filament) muscle Z-line, alpha 2	157					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex	actin binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	13	all_cancers(3;8.53e-08)|all_epithelial(6;7.79e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)		GBM - Glioblastoma multiforme(2;5.01e-06)|STAD - Stomach adenocarcinoma(10;0.000512)|all cancers(2;0.00326)			TTATTGCATGCATAGAAAGCC	0.338000													11	79					0	0	1	0	0
PTGFRN	5738	broad.mit.edu	37	1	117484384	117484384	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:117484384C>T	ENST00000393203.2	+	2	244	c.97C>T	c.(97-99)Cga>Tga	p.R33*		NM_020440.2	NP_065173.2	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor inhibitor	33	Ig-like C2-type 1.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)	46	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		GACCCTGGTTCGAGTGGTGGG	0.537000													13	83					0	0	1	0	0
SELENBP1	8991	broad.mit.edu	37	1	151345138	151345138	+	Translation_Start_Site	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:151345138G>C	ENST00000435071.1	-	0	41				SELENBP1_ENST00000447402.3_De_novo_Start_OutOfFrame|SELENBP1_ENST00000368868.5_De_novo_Start_OutOfFrame|SELENBP1_ENST00000426705.2_De_novo_Start_OutOfFrame|SELENBP1_ENST00000473693.1_5'UTR			Q13228	SBP1_HUMAN	selenium binding protein 1						protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|urinary_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGTACACTTTGATCCCGGCGG	0.577000											OREG0003915	type=REGULATORY REGION|Gene=SELENBP1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	11	99					0	0	1	0	0
CTNNB1	1499	broad.mit.edu	37	3	41274855	41274855	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:41274855C>T	ENST00000349496.5	+	8	1385	c.1105C>T	c.(1105-1107)Cac>Tac	p.H369Y	CTNNB1_ENST00000396185.3_Missense_Mutation_p.H369Y|CTNNB1_ENST00000396183.3_Missense_Mutation_p.H369Y|CTNNB1_ENST00000405570.1_Missense_Mutation_p.H369Y|CTNNB1_ENST00000453024.1_Missense_Mutation_p.H362Y	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	369					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	TTTAGGACTTCACCTGACAGA	0.398000		15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				7	85					0	0	1	0	0
TMEM33	55161	broad.mit.edu	37	4	41951378	41951378	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr4:41951378C>T	ENST00000504986.1	+	6	955	c.590C>T	c.(589-591)tCg>tTg	p.S197L	TMEM33_ENST00000325094.5_Missense_Mutation_p.S197L|TMEM33_ENST00000513702.1_Missense_Mutation_p.S197L	NM_018126.2	NP_060596.2	P57088	TMM33_HUMAN	transmembrane protein 33	197						integral to membrane|melanosome	protein binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(1)	9						CTTCGATATTCGTCTCGAAGA	0.313000													10	83					0	0	1	0	0
SLC7A8	23428	broad.mit.edu	37	14	23635568	23635568	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr14:23635568C>G	ENST00000316902.7	-	2	1058	c.333G>C	c.(331-333)aaG>aaC	p.K111N	SLC7A8_ENST00000469263.1_Missense_Mutation_p.K111N	NM_012244.3	NP_036376.2	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 8	111					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			autonomic_ganglia(1)|endometrium(6)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|skin(1)	24	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	CGAAGATGTCCTTGACATAGG	0.512000													12	104					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904917	55904917	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr11:55904917G>A	ENST00000301529.1	-	1	277	c.278C>T	c.(277-279)tCa>tTa	p.S93L		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					TTCATAGAATGAGGTAGTTTT	0.418000													9	145					0	0	1	0	0
SAMD4B	55095	broad.mit.edu	37	19	39870669	39870669	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr19:39870669C>T	ENST00000314471.6	+	12	2629	c.1594C>T	c.(1594-1596)Cgg>Tgg	p.R532W	SAMD4B_ENST00000598913.1_Missense_Mutation_p.R532W|SAMD4B_ENST00000596368.1_Intron	NM_018028.2	NP_060498.2	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	532							protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(2)	15	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			GAAGCTCCTCCGGACATTCCC	0.582000													4	18					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23874017	23874017	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr14:23874017G>A	ENST00000405093.3	-	7	615	c.545C>T	c.(544-546)gCg>gTg	p.A182V	MYH6_ENST00000356287.3_Missense_Mutation_p.A182V	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	182	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		AGTCTTCCCCGCCCCGGATTC	0.552000													10	69					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102911	168102911	+	Missense_Mutation	SNP	A	A	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr2:168102911A>T	ENST00000409195.1	+	9	5098	c.5009A>T	c.(5008-5010)gAa>gTa	p.E1670V	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E1670V|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.E1448V	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1495					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TTCTCTGAGGAAAGATCTGTA	0.313000													5	74					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46123887	46123887	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr12:46123887C>T	ENST00000334344.6	+	2	325	c.153C>T	c.(151-153)taC>taT	p.Y51Y	ARID2_ENST00000422737.1_5'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	51	ARID.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ACGGTCTCTACACCAGAGTCA	0.532000			"""N, S, F"""		hepatocellular carcinoma								10	73					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	31983706	31983706	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr5:31983706C>T	ENST00000438447.1	+	3	1310	c.922C>T	c.(922-924)Cgc>Tgc	p.R308C	PDZD2_ENST00000282493.3_Missense_Mutation_p.R308C			O15018	PDZD2_HUMAN	PDZ domain containing 2	308					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						CAATGACAAACGCCGCTTCTC	0.493000													36	88					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152083634	152083634	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:152083634C>G	ENST00000368804.1	-	2	2058	c.2059G>C	c.(2059-2061)Gag>Cag	p.E687Q		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	687					keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTCCTCCTCAGCTAGCTCC	0.637000													15	120					0	0	1	0	0
PALM2	114299	broad.mit.edu	37	9	112705583	112705583	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr9:112705583G>A	ENST00000448454.2	+	8	1120	c.1120G>A	c.(1120-1122)Ggg>Agg	p.G374R	AKAP2_ENST00000555236.1_Intron|AKAP2_ENST00000510514.5_Intron|PALM2_ENST00000483909.1_Missense_Mutation_p.G338R|PALM2_ENST00000314527.4_Missense_Mutation_p.G372R|PALM2-AKAP2_ENST00000302798.7_Intron|PALM2_ENST00000374531.2_Missense_Mutation_p.G340R|PALM2-AKAP2_ENST00000374530.3_Intron					paralemmin 2											breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	18						GCTTGTGTCCGGGAGGCCGGT	0.547000													7	91					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68598113	68598113	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr16:68598113G>C	ENST00000570495.1	+	5	1715	c.1423G>C	c.(1423-1425)Gag>Cag	p.E475Q	RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000563169.2_Missense_Mutation_p.E475Q|ZFP90_ENST00000398253.2_Missense_Mutation_p.E475Q			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	475					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		CCATACTGCAGAGAACCCCTA	0.418000													10	140					0	0	1	0	0
SLC35A4	113829	broad.mit.edu	37	5	139947502	139947502	+	Missense_Mutation	SNP	T	T	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr5:139947502T>G	ENST00000514199.1	+	2	2434	c.748T>G	c.(748-750)Tca>Gca	p.S250A	SLC35A4_ENST00000323146.3_Missense_Mutation_p.S250A|APBB3_ENST00000507279.1_Intron			Q96G79	S35A4_HUMAN	solute carrier family 35, member A4	250	Leu-rich.					Golgi membrane|integral to membrane	sugar:hydrogen symporter activity			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAAGGTTTCTCAGGATGGGC	0.562000													8	65					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262058	140262058	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr5:140262058A>G	ENST00000289272.2	+	1	205	c.205A>G	c.(205-207)Aaa>Gaa	p.K69E	PCDHA6_ENST00000529310.1_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.K69E|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGCGTCCAAAAGACACGG	0.627000													13	198					0	0	1	0	0
CD97	976	broad.mit.edu	37	19	14501807	14501807	+	Missense_Mutation	SNP	A	A	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr19:14501807A>T	ENST00000242786.5	+	4	342	c.262A>T	c.(262-264)Agc>Tgc	p.S88C	CD97_ENST00000587728.1_3'UTR|CD97_ENST00000358600.3_Missense_Mutation_p.S88C|CD97_ENST00000357355.3_Missense_Mutation_p.S88C	NM_078481.3	NP_510966.1	P48960	CD97_HUMAN	CD97 molecule	88	EGF-like 2; calcium-binding (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						CACAGAGGGGAGCTACGACTG	0.527000													9	69					0	0	1	0	0
NDUFB8	4714	broad.mit.edu	37	10	102289582	102289582	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr10:102289582C>G	ENST00000531258.1	-	1	56	c.27G>C	c.(25-27)ttG>ttC	p.L9F	NDUFB8_ENST00000370320.4_Missense_Mutation_p.L9F|NDUFB8_ENST00000370322.1_Intron|SEC31B_ENST00000535773.1_5'UTR|NDUFB8_ENST00000557395.1_Missense_Mutation_p.L9F|NDUFB8_ENST00000299166.4_Missense_Mutation_p.L9F			O95169	NDUB8_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	9					mitochondrial electron transport, NADH to ubiquinone|transport	endoplasmic reticulum|integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(2)|lung(2)	4		Colorectal(252;0.234)		Epithelial(162;5.68e-10)|all cancers(201;4.05e-08)	NADH(DB00157)	ACTGGACTCCCAAGACCCCGG	0.652000													3	29					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32630547	32630547	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr9:32630547C>T	ENST00000242310.4	-	1	5120	c.5031G>A	c.(5029-5031)acG>acA	p.T1677T		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1677					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CATCTCGAGACGTACTGAGGG	0.488000													18	197					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49009244	49009244	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr4:49009244A>G	ENST00000226432.4	+	8	1270	c.1087A>G	c.(1087-1089)Aat>Gat	p.N363D	CWH43_ENST00000513409.1_Missense_Mutation_p.N336D	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	363					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						TATCGGGCTGAATATGCTATT	0.333000													4	36					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41065521	41065521	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr5:41065521C>T	ENST00000399564.4	-	4	723	c.273G>A	c.(271-273)gtG>gtA	p.V91V		NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CTTCATACATCACAGAGTTGA	0.423000													14	41					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88329213	88329213	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr13:88329213G>A	ENST00000325089.6	+	2	1789	c.1570G>A	c.(1570-1572)Gtc>Atc	p.V524I	SLITRK5_ENST00000400028.3_Missense_Mutation_p.V283I	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	524						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GCCCTCAGGCGTCTTCTCTGG	0.527000													9	98					0	0	1	0	0
ARMC8	25852	broad.mit.edu	37	3	137940804	137940804	+	Silent	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:137940804G>A	ENST00000469044.1	+	3	430	c.159G>A	c.(157-159)caG>caA	p.Q53Q	ARMC8_ENST00000461822.1_Silent_p.Q53Q|ARMC8_ENST00000393058.3_Silent_p.Q43Q|ARMC8_ENST00000485396.1_Silent_p.Q11Q|ARMC8_ENST00000538260.1_Silent_p.Q53Q|ARMC8_ENST00000471453.1_Silent_p.Q39Q|ARMC8_ENST00000491704.1_Silent_p.Q11Q|ARMC8_ENST00000489213.1_Silent_p.Q11Q|ARMC8_ENST00000470821.1_Silent_p.Q53Q|ARMC8_ENST00000358441.2_Silent_p.Q39Q|ARMC8_ENST00000481646.1_Silent_p.Q39Q	NM_001267041.1|NM_001267042.1	NP_001253970.1|NP_001253971.1	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8	53							binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(5)|upper_aerodigestive_tract(1)	16						ACAACAAGCAGAAAGCCAATC	0.353000													6	136					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121208192	121208192	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:121208192G>C	ENST00000264233.5	-	16	3714	c.3586C>G	c.(3586-3588)Ctg>Gtg	p.L1196V		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	1196					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TGCTTTCGCAGGTACTGGTTA	0.348000								DNA polymerases (catalytic subunits)					14	360					0	0	1	0	0
COIL	8161	broad.mit.edu	37	17	55027263	55027263	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr17:55027263G>C	ENST00000240316.4	-	2	1374	c.1340C>G	c.(1339-1341)tCt>tGt	p.S447C		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	447	2 X 4 AA repeats of S-L-P-A.					Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					GATAATAGTAGATGAATTTTT	0.408000													15	90					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr14:23887583C>T	ENST00000355349.3	-	30	4167	c.4005G>A	c.(4003-4005)tcG>tcA	p.S1335S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S1335S(3)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													4	53					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51524139	51524139	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr6:51524139G>C	ENST00000371117.3	-	61	11060	c.10785C>G	c.(10783-10785)atC>atG	p.I3595M		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3595					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GAATAAACCTGATTTGGTTTT	0.428000													7	153					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52387662	52387662	+	Silent	SNP	C	C	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr8:52387662C>A	ENST00000356297.4	-	7	664	c.564G>T	c.(562-564)ctG>ctT	p.L188L	PXDNL_ENST00000543296.1_Silent_p.L188L	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	188	LRRCT.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity	p.L188L(1)		NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CCAGCCACATCAGATCACAGT	0.517000													4	34					0.000602214	0.000610879	1	1	0
WDR52	55779	broad.mit.edu	37	3	113084971	113084971	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:113084971C>T	ENST00000393845.2	-	19	2696	c.2630G>A	c.(2629-2631)gGa>gAa	p.G877E	WDR52_ENST00000295868.2_Missense_Mutation_p.G877E	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	877										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						GCCATCTGCTCCAGCAGTCAC	0.353000													9	157					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166850813	166850813	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr2:166850813C>G	ENST00000423058.2	-	25	4712	c.4695G>C	c.(4693-4695)caG>caC	p.Q1565H	AC010127.3_ENST00000597623.1_RNA|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.Q1565H|SCN1A_ENST00000409050.1_Missense_Mutation_p.Q1537H|SCN1A_ENST00000375405.3_Missense_Mutation_p.Q1554H	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1565						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CATATTCACTCTGGTCATCTG	0.393000													10	83					0	0	1	0	0
GJC3	349149	broad.mit.edu	37	7	99527091	99527091	+	Silent	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr7:99527091G>A	ENST00000312891.2	-	1	152	c.153C>T	c.(151-153)ttC>ttT	p.F51F	RP4-604G5.1_ENST00000456499.1_RNA	NM_181538.2	NP_853516.1	Q8NFK1	CXG3_HUMAN	gap junction protein, gamma 3, 30.2kDa	51						connexon complex|integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	9	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					TGTGACACACGAATTCACTCT	0.637000													7	87					0	0	1	0	0
CHSY3	337876	broad.mit.edu	37	5	129521409	129521409	+	Silent	SNP	C	C	T	rs148231534		TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr5:129521409C>T	ENST00000305031.4	+	3	2932	c.2574C>T	c.(2572-2574)ttC>ttT	p.F858F		NM_175856.4	NP_787052.3	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	858						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		CAAGTACTTTCGCCTCAACCA	0.443000													13	82					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21450358	21450358	+	Nonsense_Mutation	SNP	G	G	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr12:21450358G>T	ENST00000307378.6	-	10	1775	c.1055C>A	c.(1054-1056)tCa>tAa	p.S352*	SLCO1A2_ENST00000452078.1_Nonsense_Mutation_p.S352*|SLCO1A2_ENST00000390670.3_Nonsense_Mutation_p.S350*|SLCO1A2_ENST00000537524.1_Nonsense_Mutation_p.S220*|SLCO1A2_ENST00000458504.1_Nonsense_Mutation_p.S220*	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	352					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						GATTGCATCTGAAGATGATAT	0.403000													4	47					0.00024832	0.000253718	1	1	0
RIOK1	83732	broad.mit.edu	37	6	7405510	7405510	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr6:7405510C>T	ENST00000379834.2	+	12	1632	c.1125C>T	c.(1123-1125)gtC>gtT	p.V375V		NM_031480.2|NM_153005.1	NP_113668.2|NP_694550.1	Q9BRS2	RIOK1_HUMAN	RIO kinase 1	375	Protein kinase.		V -> I (in dbSNP:rs56067778).				ATP binding|protein serine/threonine kinase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19	Ovarian(93;0.0418)					GTGTTGCTGTCATGACTGTGC	0.393000													5	87					0	0	1	0	0
C4BPA	722	broad.mit.edu	37	1	207287510	207287510	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:207287510C>T	ENST00000367070.3	+	3	402	c.208C>T	c.(208-210)Cgc>Tgc	p.R70C		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	70	Sushi 1.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						GACTGAGACACGCTTCAAAAC	0.473000													9	155					0	0	1	0	0
MTR	4548	broad.mit.edu	37	1	237037072	237037072	+	Splice_Site	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:237037072G>A	ENST00000366577.5	+	23	2799		c.e23-1		MTR_ENST00000535889.1_Splice_Site	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase						nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	CTGTGCCTCAGAGTTATTGAT	0.358000													4	56					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161609	90161609	+	RNA	SNP	A	A	G	rs139928438	by1000genomes	TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr16:90161609A>G	ENST00000567960.1	+	0	345				TUBB8P7_ENST00000564451.1_RNA																							TGATGGAGTCAGTGATGGACG	0.617000													4	58					0	0	1	0	0
RFX1	5989	broad.mit.edu	37	19	14076339	14076339	+	Silent	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr19:14076339G>A	ENST00000254325.4	-	16	2367	c.2133C>T	c.(2131-2133)atC>atT	p.I711I		NM_002918.4	NP_002909.4	P22670	RFX1_HUMAN	regulatory factor X, 1 (influences HLA class II expression)	711					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			CAAAGTTCCGGATCGCTTGGG	0.662000													10	93					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9202132	9202132	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr5:9202132G>C	ENST00000382496.5	-	9	1532	c.867C>G	c.(865-867)aaC>aaG	p.N289K		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	289	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						TCTGCAATTCGTTGTAGTAAA	0.478000													4	71					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106509636	106509636	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr7:106509636C>T	ENST00000359195.3	+	2	1940	c.1630C>T	c.(1630-1632)Cga>Tga	p.R544*	PIK3CG_ENST00000496166.1_Nonsense_Mutation_p.R544*|PIK3CG_ENST00000440650.2_Nonsense_Mutation_p.R544*	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	544					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						GGACCGGGTTCGAGCAGAAAT	0.542000													13	61					0	0	1	0	0
ZNF440	126070	broad.mit.edu	37	19	11943646	11943646	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr19:11943646C>T	ENST00000304060.5	+	4	1819	c.1655C>T	c.(1654-1656)tCa>tTa	p.S552L		NM_152357.2	NP_689570.2	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	552					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(9)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						GGAAAGCCTTCAGATCTGCCC	0.493000													10	61					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138957170	138957170	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr7:138957170C>T	ENST00000288561.8	+	9	1699	c.1450C>T	c.(1450-1452)Caa>Taa	p.Q484*	UBN2_ENST00000473989.2_Nonsense_Mutation_p.Q567*	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2	567										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						GGCTCGTAGTCAAGCTAAGTG	0.393000													9	157					0	0	1	0	0
GGT3P	2679	broad.mit.edu	37	22	18769145	18769145	+	RNA	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr22:18769145G>A	ENST00000412448.1	-	0	1141																											TGAGGCTGCCGTTGTAGAAGG	0.612000													4	33					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1218445	1218445	+	Missense_Mutation	SNP	A	A	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr19:1218445A>T	ENST00000326873.7	+	2	1493	c.320A>T	c.(319-321)cAc>cTc	p.H107L	STK11_ENST00000585748.1_3'UTR	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	107	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(3)|p.H107R(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTTACGGCACAAAAATGTC	0.547000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			19	192					0	0	1	0	0
SATB2	23314	broad.mit.edu	37	2	200188670	200188670	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr2:200188670C>T	ENST00000443023.1	-	8	2686	c.1221G>A	c.(1219-1221)tcG>tcA	p.S407S	SATB2_ENST00000260926.5_Silent_p.S466S|SATB2_ENST00000428695.1_Silent_p.S348S|SATB2_ENST00000457245.1_Silent_p.S466S|SATB2_ENST00000417098.1_Silent_p.S466S			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	466						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TTGTCGGTGTCGAGGTTTTGG	0.458000													17	104					0	0	1	0	0
HIST1H3C	8352	broad.mit.edu	37	6	26045649	26045649	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr6:26045649C>T	ENST00000540144.1	+	1	11	c.11C>T	c.(10-12)aCg>aTg	p.T4M		NM_003531.2	NP_003522.1	P68431	H31_HUMAN	histone cluster 1, H3c	4					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|skin(1)	8						ATGGCTCGTACGAAGCAAACA	0.507000													4	121					0	0	1	0	0
CREBRF	153222	broad.mit.edu	37	5	172517753	172517753	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr5:172517753C>G	ENST00000540014.1	+	4	890	c.571C>G	c.(571-573)Ctg>Gtg	p.L191V	CREBRF_ENST00000296953.2_Missense_Mutation_p.L191V|CREBRF_ENST00000520420.1_Missense_Mutation_p.L191V|CREBRF_ENST00000522692.1_Missense_Mutation_p.L191V			Q8IUR6	CE041_HUMAN	CREB3 regulatory factor	191							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity										TTCTAAGACTCTGCAGGCTGA	0.428000													10	44					0	0	1	0	0
TMCC2	9911	broad.mit.edu	37	1	205238090	205238090	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:205238090G>A	ENST00000358024.3	+	3	1149	c.760G>A	c.(760-762)Gac>Aac	p.D254N	TMCC2_ENST00000545499.1_Missense_Mutation_p.D176N|TMCC2_ENST00000495538.1_3'UTR|TMCC2_ENST00000329800.7_Missense_Mutation_p.D14N|TMCC2_ENST00000330675.7_Missense_Mutation_p.D29N	NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	254						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CGATAAGGGAGACCTGGTGGC	0.647000													5	97					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152675908	152675908	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr6:152675908C>T	ENST00000367255.5	-	67	11413	c.10812G>A	c.(10810-10812)gaG>gaA	p.E3604E	SYNE1_ENST00000341594.5_Silent_p.E3575E|SYNE1_ENST00000423061.1_Silent_p.E3611E|SYNE1_ENST00000265368.4_Silent_p.E3604E|SYNE1_ENST00000448038.1_Silent_p.E3611E	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3604					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAAACTTTTGCTCCATTAGCC	0.478000										HNSCC(10;0.0054)			10	97					0	0	1	0	0
CRISP2	7180	broad.mit.edu	37	6	49660582	49660582	+	Missense_Mutation	SNP	A	A	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr6:49660582A>C	ENST00000339139.4	-	10	872	c.636T>G	c.(634-636)agT>agG	p.S212R		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	212						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AATCACAGTTACTTAGGAGAT	0.363000													9	93					0	0	1	0	0
NTHL1	4913	broad.mit.edu	37	16	2096334	2096334	+	Missense_Mutation	SNP	G	G	A	rs139165943	byFrequency	TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr16:2096334G>A	ENST00000219066.1	-	2	191	c.173C>T	c.(172-174)cCg>cTg	p.P58L		NM_002528.5	NP_002519.1	P78549	NTHL1_HUMAN	nth endonuclease III-like 1 (E. coli)	58					depyrimidination|nucleotide-excision repair, DNA incision, 5'-to lesion	nucleoplasm	4 iron, 4 sulfur cluster binding|double-stranded DNA binding|endonuclease activity|metal ion binding|oxidized pyrimidine base lesion DNA N-glycosylase activity|protein binding			lung(1)	1						TGCTTTCCGCGGACGCTTCAC	0.632000								Base excision repair (BER), DNA glycosylases					14	66					0	0	1	0	0
ZNF470	388566	broad.mit.edu	37	19	57086066	57086066	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr19:57086066G>T	ENST00000330619.8	+	5	933	c.247G>T	c.(247-249)Gtg>Ttg	p.V83L	ZNF470_ENST00000601902.1_Missense_Mutation_p.V83L|ZNF470_ENST00000391709.3_Missense_Mutation_p.V83L	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	83	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AGACCCTTGGGTGATAAAAGG	0.428000													4	45					0.0215528	0.0217067	1	1	0
PLXNB1	5364	broad.mit.edu	37	3	48454538	48454538	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:48454538G>A	ENST00000358536.4	-	24	4845	c.4576C>T	c.(4576-4578)Cag>Tag	p.Q1526*	PLXNB1_ENST00000456774.1_Nonsense_Mutation_p.Q1343*|PLXNB1_ENST00000358459.4_Nonsense_Mutation_p.Q1343*|PLXNB1_ENST00000296440.6_Nonsense_Mutation_p.Q1526*|PLXNB1_ENST00000448774.2_Nonsense_Mutation_p.Q137*	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1526					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGCTGGATCTGAACCTTCTTA	0.607000													6	104					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71044037	71044037	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr2:71044037G>A	ENST00000272367.2	-	4	552	c.476C>T	c.(475-477)gCc>gTc	p.A159V	CLEC4F_ENST00000426626.1_Missense_Mutation_p.A159V	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	159					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						CAATGTAGTGGCATCCTTTAG	0.483000													24	81					0	0	1	0	0
PCMTD1	115294	broad.mit.edu	37	8	52732960	52732960	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr8:52732960G>A	ENST00000360540.5	-	7	1431	c.1025C>T	c.(1024-1026)cCc>cTc	p.P342L	PCMTD1_ENST00000522514.1_Missense_Mutation_p.P342L|PCMTD1_ENST00000519559.1_5'UTR|PCMTD1_ENST00000544451.1_Missense_Mutation_p.P266L	NM_052937.2	NP_443169.2	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	342						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	p.P342L(2)		NS(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(17)|prostate(2)|skin(8)|soft_tissue(1)	37		Lung NSC(129;0.0795)|all_lung(136;0.144)				TTCAGGGAGGGGCAGCTTCAT	0.353000													4	137					0	0	1	0	0
IGHV1OR15-9	390531	broad.mit.edu	37	15	20170174	20170174	+	RNA	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr15:20170174G>A	ENST00000338912.5	-	0	97																											TGAGGCCCCAGGCTTCTTCAC	0.582000													8	83					0	0	1	0	0
POLG	5428	broad.mit.edu	37	15	89867078	89867078	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr15:89867078G>A	ENST00000268124.5	-	12	2458	c.2125C>T	c.(2125-2127)Cga>Tga	p.R709*	POLG_ENST00000442287.2_Nonsense_Mutation_p.R709*	NM_001126131.1|NM_002693.2	NP_001119603.1|NP_002684.1	P54098	DPOG1_HUMAN	polymerase (DNA directed), gamma	709					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(3)|urinary_tract(2)	33	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			ACTGCAGCTCGCAAGTTCTCC	0.572000								DNA polymerases (catalytic subunits)					7	37					0	0	1	0	0
JOSD2	126119	broad.mit.edu	37	19	51010853	51010853	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr19:51010853C>T	ENST00000598418.1	-	3	503	c.250G>A	c.(250-252)Gcc>Acc	p.A84T	JOSD2_ENST00000391815.3_Missense_Mutation_p.A84T|JOSD2_ENST00000595669.1_Intron|JOSD2_ENST00000601423.1_Missense_Mutation_p.A84T	NM_001270639.1|NM_001270640.1	NP_001257568.1|NP_001257569.1	Q8TAC2	JOS2_HUMAN	Josephin domain containing 2	84	Josephin.				protein deubiquitination		ubiquitin-specific protease activity			kidney(1)|lung(3)|prostate(1)	5		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0364)		CACCACACGGCGGCCAGGCCC	0.667000													8	139					0	0	1	0	0
TRIM10	10107	broad.mit.edu	37	6	30126364	30126364	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr6:30126364C>T	ENST00000449742.2	-	3	643	c.568G>A	c.(568-570)Gca>Aca	p.A190T	TRIM10_ENST00000376704.3_Missense_Mutation_p.A190T	NM_006778.3	NP_006769.2	Q9UDY6	TRI10_HUMAN	tripartite motif containing 10	190						cytoplasm	zinc ion binding	p.A190T(1)		ovary(1)	1						CTCAGGTGTGCGAACTCAGAA	0.512000													6	348					0	0	1	0	0
ABHD6	57406	broad.mit.edu	37	3	58252993	58252993	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:58252993G>A	ENST00000478253.1	+	4	698	c.197G>A	c.(196-198)gGc>gAc	p.G66D	ABHD6_ENST00000295962.4_Missense_Mutation_p.G66D			Q9BV23	ABHD6_HUMAN	abhydrolase domain containing 6	66						integral to membrane	acylglycerol lipase activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	16				BRCA - Breast invasive adenocarcinoma(55;0.000225)|KIRC - Kidney renal clear cell carcinoma(284;0.0471)|Kidney(284;0.0589)|OV - Ovarian serous cystadenocarcinoma(275;0.209)		TCCTTCCGGGGCAGGCCTGGG	0.517000													4	73					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18368439	18368439	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr19:18368439G>A	ENST00000392413.3	-	4	3870	c.3655C>T	c.(3655-3657)Cgc>Tgc	p.R1219C	KIAA1683_ENST00000600328.2_Missense_Mutation_p.R1032C|KIAA1683_ENST00000600359.2_Missense_Mutation_p.R986C	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	0						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						TGGAAGCAGCGATGGTCAGAT	0.662000													12	49					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70514051	70514051	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr8:70514051G>A	ENST00000260128.4	+	10	1765	c.1048G>A	c.(1048-1050)Gaa>Aaa	p.E350K	SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000419716.3_Missense_Mutation_p.E350K|SULF1_ENST00000458141.2_Missense_Mutation_p.E350K|SULF1_ENST00000402687.4_Missense_Mutation_p.E350K	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	350					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TCCAAGTGTAGAACCAGGATC	0.408000													15	169					0	0	1	0	0
CTNNB1	1499	broad.mit.edu	37	3	41266471	41266471	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:41266471C>T	ENST00000349496.5	+	4	548	c.268C>T	c.(268-270)Cga>Tga	p.R90*	CTNNB1_ENST00000396185.3_Nonsense_Mutation_p.R90*|CTNNB1_ENST00000396183.3_Nonsense_Mutation_p.R90*|CTNNB1_ENST00000405570.1_Nonsense_Mutation_p.R90*|CTNNB1_ENST00000453024.1_Nonsense_Mutation_p.R83*	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	90					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.A5_Q143del(7)|p.Q28_H134del(5)|p.W25_I140del(3)|p.T3_A126del(2)|p.?(2)|p.L10_N141del(2)|p.A5_Y142>D(2)|p.M5_N141>D(2)|p.M1_V173del(1)|p.A5_Q143>E(1)|p.A13_R151del(1)|p.A20_S111del(1)|p.I35_K170del(1)|p.Y30_A97del(1)|p.E15_I140>V(1)|p.V22_T102del(1)|p.H24_M131del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.P16_K133del(1)	CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	TGCAATGACTCGAGCTCAGAG	0.428000		15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				13	153					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248550957	248550957	+	Silent	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:248550957G>A	ENST00000355728.2	+	1	48	c.48G>A	c.(46-48)ggG>ggA	p.G16G		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G16G(1)		endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCCTCATGGGGCTCTTCACTC	0.423000													4	101					0	0	1	0	0
CRISP1	167	broad.mit.edu	37	6	49814367	49814367	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr6:49814367C>G	ENST00000335847.4	-	5	402	c.301G>C	c.(301-303)Gaa>Caa	p.E101Q	CRISP1_ENST00000536021.1_Missense_Mutation_p.E101Q|CRISP1_ENST00000507853.1_Missense_Mutation_p.E101Q|CRISP1_ENST00000505118.1_Missense_Mutation_p.E101Q|CRISP1_ENST00000355791.2_Missense_Mutation_p.E101Q|CRISP1_ENST00000329411.5_Missense_Mutation_p.E101Q	NM_001131.2	NP_001122.2	P54107	CRIS1_HUMAN	cysteine-rich secretory protein 1	101					fusion of sperm to egg plasma membrane	extracellular space				endometrium(1)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0358)					TGCATATTTTCTCCACAAAAG	0.363000													15	76					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8457627	8457627	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr11:8457627C>T	ENST00000447869.1	-	9	1925	c.1007G>A	c.(1006-1008)aGa>aAa	p.R336K	STK33_ENST00000315204.1_Missense_Mutation_p.R336K|STK33_ENST00000473980.1_5'UTR|STK33_ENST00000358872.3_Missense_Mutation_p.R149K|STK33_ENST00000534493.1_Missense_Mutation_p.R295K|STK33_ENST00000396672.1_Missense_Mutation_p.R336K|STK33_ENST00000396673.1_Missense_Mutation_p.R336K			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	336	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		TTCTCCTTTTCTTATTAACTC	0.318000													9	110					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180334096	180334096	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:180334096G>C	ENST00000442201.2	-	19	2761	c.2642C>G	c.(2641-2643)tCt>tGt	p.S881C	CCDC39_ENST00000273654.4_3'UTR|TTC14_ENST00000382584.4_Intron	NM_181426.1	NP_852091.1	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	881	Ser-rich.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ATGTGAAGGAGATCTAGAGCT	0.413000													4	80					0	0	1	0	0
VGLL4	9686	broad.mit.edu	37	3	11600092	11600092	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:11600092G>A	ENST00000273038.3	-	6	1176	c.811C>T	c.(811-813)Cag>Tag	p.Q271*	VGLL4_ENST00000404339.1_Nonsense_Mutation_p.Q276*|VGLL4_ENST00000424529.2_Nonsense_Mutation_p.Q187*|VGLL4_ENST00000451674.2_Nonsense_Mutation_p.Q191*|VGLL4_ENST00000413604.1_Nonsense_Mutation_p.Q212*|VGLL4_ENST00000430365.2_Nonsense_Mutation_p.Q277*	NM_014667.2	NP_055482.2	Q14135	VGLL4_HUMAN	vestigial like 4 (Drosophila)	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|endometrium(1)|large_intestine(1)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		CTGGCGGGCTGGCCCCTGCGA	0.642000													13	69					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141283496	141283496	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr2:141283496G>A	ENST00000389484.3	-	49	8914	c.7943C>T	c.(7942-7944)tCt>tTt	p.S2648F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2648	LDL-receptor class A 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGTGAGGTAGAATTACATCT	0.388000										TSP Lung(27;0.18)			5	60					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44086606	44086606	+	Missense_Mutation	SNP	A	A	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:44086606A>T	ENST00000359947.4	+	32	5802	c.5462A>T	c.(5461-5463)cAg>cTg	p.Q1821L	PTPRF_ENST00000372413.3_Missense_Mutation_p.Q1812L|PTPRF_ENST00000372414.3_Missense_Mutation_p.Q1821L|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000422171.2_Missense_Mutation_p.Q1180L|PTPRF_ENST00000438120.1_Missense_Mutation_p.Q1812L	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1821	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TTCATCGGGCAGGTGCATAAG	0.612000													6	45					0	0	1	0	0
SLFN13	146857	broad.mit.edu	37	17	33771680	33771680	+	Silent	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr17:33771680G>A	ENST00000285013.6	-	3	1295	c.1020C>T	c.(1018-1020)ccC>ccT	p.P340P	SLFN13_ENST00000360502.2_Silent_p.P22P|SLFN13_ENST00000542635.1_Silent_p.P340P|SLFN13_ENST00000526861.1_Silent_p.P340P|SLFN13_ENST00000534689.1_Silent_p.P22P|SLFN13_ENST00000533791.1_Silent_p.P340P	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	340						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CAGTTGTCAAGGGGCGGATGT	0.488000													8	102					0	0	1	0	0
DCAF5	8816	broad.mit.edu	37	14	69522198	69522198	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr14:69522198T>A	ENST00000341516.5	-	9	1352	c.1205A>T	c.(1204-1206)cAt>cTt	p.H402L	DCAF5_ENST00000553293.1_5'UTR|DCAF5_ENST00000554215.1_Missense_Mutation_p.H320L|DCAF5_ENST00000557386.1_Missense_Mutation_p.H401L|DCAF5_ENST00000556847.1_Missense_Mutation_p.H320L	NM_003861.2	NP_003852.1	Q96JK2	DCAF5_HUMAN	DDB1 and CUL4 associated factor 5	402						CUL4 RING ubiquitin ligase complex				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|upper_aerodigestive_tract(2)	29						GGCGTAGTCATGCGACAGGCC	0.577000													33	154					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121712219	121712219	+	Silent	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:121712219G>A	ENST00000273691.3	-	6	1350	c.1245C>T	c.(1243-1245)caC>caT	p.H415H	ILDR1_ENST00000344209.5_Silent_p.H459H|ILDR1_ENST00000462014.1_Silent_p.H427H|ILDR1_ENST00000393631.1_Silent_p.H370H|ILDR1_ENST00000460554.1_5'UTR	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	459						cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		GTCGTCTCCCGTGCCTCTGAG	0.687000													12	33					0	0	1	0	0
TAS2R31	259290	broad.mit.edu	37	12	11183305	11183305	+	Missense_Mutation	SNP	C	C	G	rs149012476	by1000genomes	TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr12:11183305C>G	ENST00000390675.2	-	1	701	c.630G>C	c.(628-630)caG>caC	p.Q210H	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176885.2	NP_795366.2	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	210					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|lung(6)	7						TACCATGGAGCTGCATCTTCT	0.428000													4	215					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39806219	39806219	+	Nonsense_Mutation	SNP	G	G	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:39806219G>T	ENST00000564288.1	+	39	11038	c.10261G>T	c.(10261-10263)Gag>Tag	p.E3421*	MACF1_ENST00000545844.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000372915.3_Nonsense_Mutation_p.E3426*|MACF1_ENST00000289893.4_Nonsense_Mutation_p.E1861*|MACF1_ENST00000567887.1_Nonsense_Mutation_p.E3458*|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000361689.2_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	3426					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGTCAGTCAGGAGCTGGAGTG	0.443000													5	45					8.12818e-05	8.3655e-05	1	1	0
GRIA4	2893	broad.mit.edu	37	11	105845108	105845108	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr11:105845108G>C	ENST00000393127.2	+	16	2927	c.2481G>C	c.(2479-2481)ttG>ttC	p.L827F	GRIA4_ENST00000282499.5_Missense_Mutation_p.L827F|GRIA4_ENST00000525187.1_Missense_Mutation_p.L827F|GRIA4_ENST00000530497.1_Missense_Mutation_p.L827F|GRIA4_ENST00000533094.1_3'UTR	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	827					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	GCTTGGGCTTGGCAATGCTGG	0.498000													12	76					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168104131	168104131	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr2:168104131G>A	ENST00000409195.1	+	9	6318	c.6229G>A	c.(6229-6231)Gaa>Aaa	p.E2077K	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E2077K|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.E1855K	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1902					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TCTTAGAGATGAATATATGAG	0.373000													4	58					0	0	1	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42133427	42133427	+	Splice_Site	SNP	A	A	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr15:42133427A>G	ENST00000382448.4	+	11	1094		c.e11-1		JMJD7-PLA2G4B_ENST00000458483.1_Splice_Site|PLA2G4B_ENST00000452633.1_Splice_Site|JMJD7-PLA2G4B_ENST00000342159.4_Splice_Site	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN							arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						GGCTCTTTCCAGGGCTGACCG	0.657000													5	132					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60895805	60895805	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr20:60895805G>A	ENST00000252999.3	-	49	6704	c.6638C>T	c.(6637-6639)gCt>gTt	p.A2213V		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2213	Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGCAGGTCAGCGATGGAGGC	0.687000													5	22					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98421912	98421912	+	Silent	SNP	A	A	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr2:98421912A>G	ENST00000186436.5	-	21	2439	c.2211T>C	c.(2209-2211)atT>atC	p.I737I		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	737						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						AAATGTTTGCAATCTATAAAG	0.373000													5	56					0	0	1	0	0
MMP21	118856	broad.mit.edu	37	10	127458964	127458964	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr10:127458964G>T	ENST00000368808.3	-	5	1175	c.1176C>A	c.(1174-1176)caC>caA	p.H392Q		NM_147191.1	NP_671724.1	Q8N119	MMP21_HUMAN	matrix metallopeptidase 21	392					proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	16		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CATCTATGTTGTGTGTTGGGA	0.418000													11	114					1.61879e-10	1.69074e-10	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414313	20414313	+	Silent	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr9:20414313G>A	ENST00000380338.4	-	5	817	c.531C>T	c.(529-531)agC>agT	p.S177S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S174S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	177	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								5	113					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139380215	139380215	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr8:139380215T>C	ENST00000395297.1	-	2	182	c.12A>G	c.(10-12)atA>atG	p.I4M		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	4										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CCGTTCCTTGTATTTCAGACA	0.368000										HNSCC(54;0.14)			8	75					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11117603	11117603	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr5:11117603C>T	ENST00000304623.8	-	13	2425	c.2236G>A	c.(2236-2238)Gtg>Atg	p.V746M	CTNND2_ENST00000511377.1_Missense_Mutation_p.V655M|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Missense_Mutation_p.V409M|CTNND2_ENST00000458100.2_Missense_Mutation_p.V313M|CTNND2_ENST00000359640.2_Missense_Mutation_p.V746M	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	746					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GACTGGATCACGTACAGCAAG	0.517000													37	136					0	0	1	0	0
ERAP1	51752	broad.mit.edu	37	5	96121525	96121525	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr5:96121525G>A	ENST00000296754.3	-	13	2167	c.1910C>T	c.(1909-1911)gCg>gTg	p.A637V	ERAP1_ENST00000443439.2_Missense_Mutation_p.A637V|CTD-2260A17.1_ENST00000602972.1_RNA|ERAP1_ENST00000514604.1_5'UTR|CTD-2260A17.1_ENST00000512856.1_RNA	NM_016442.3	NP_057526.3	Q9NZ08	ERAP1_HUMAN	endoplasmic reticulum aminopeptidase 1	637					angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			endometrium(7)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|stomach(2)	19		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		AATGAGACTCGCCCGATCATT	0.418000													4	60					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634946	70634946	+	Missense_Mutation	SNP	G	G	A	rs141504535		TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr14:70634946G>A	ENST00000381269.2	-	2	947	c.194C>T	c.(193-195)cCg>cTg	p.P65L	SLC8A3_ENST00000534137.1_Missense_Mutation_p.P65L|SLC8A3_ENST00000356921.2_Missense_Mutation_p.P65L|SLC8A3_ENST00000357887.3_Missense_Mutation_p.P65L|SLC8A3_ENST00000528359.1_Missense_Mutation_p.P65L	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	65					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AGGGTTCTCCGGGTACCAGAT	0.552000													9	39					0	0	1	0	0
ANKRD16	54522	broad.mit.edu	37	10	5925970	5925970	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr10:5925970G>A	ENST00000380094.5	-	4	1192	c.649C>T	c.(649-651)Cac>Tac	p.H217Y	ANKRD16_ENST00000191063.8_Missense_Mutation_p.H217Y|ANKRD16_ENST00000380092.4_Missense_Mutation_p.H217Y	NM_019046.2	NP_061919.1	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16	217										breast(1)|endometrium(1)|large_intestine(5)|lung(3)|stomach(2)	12						ACGTCGATGTGCCCACACTGG	0.463000													6	48					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14492732	14492732	+	Silent	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr5:14492732G>A	ENST00000344204.4	+	49	7713	c.7689G>A	c.(7687-7689)acG>acA	p.T2563T	TRIO_ENST00000537187.1_Silent_p.T2387T|TRIO_ENST00000344135.5_Silent_p.T62T	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2563	SH3 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					ACGATTACACGGCAGTGAAGG	0.522000													5	41					0	0	1	0	0
SOX3	6658	broad.mit.edu	37	X	139586659	139586659	+	Silent	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chrX:139586659G>A	ENST00000370536.2	-	1	566	c.567C>T	c.(565-567)atC>atT	p.I189I		NM_005634.2	NP_005625.2	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	189					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	10	Acute lymphoblastic leukemia(192;7.65e-05)					TGGCCTCGTCGATGAATGGTC	0.567000													9	38					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111965617	111965617	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:111965617C>T	ENST00000369732.3	-	6	595	c.540G>A	c.(538-540)ctG>ctA	p.L180L	OVGP1_ENST00000540696.1_Silent_p.L120L|OVGP1_ENST00000481495.1_5'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	180					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CAGCAGACAGCAGCAGCCTCG	0.537000													16	180					0	0	1	0	0
C19orf40	91442	broad.mit.edu	37	19	33464993	33464993	+	Translation_Start_Site	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr19:33464993G>A	ENST00000589646.1	+	0	291				C19orf40_ENST00000588258.1_Missense_Mutation_p.V91I|C19orf40_ENST00000590179.1_De_novo_Start_OutOfFrame|C19orf40_ENST00000590281.1_Missense_Mutation_p.V91I			Q9BTP7	FAP24_HUMAN	chromosome 19 open reading frame 40						DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7	Esophageal squamous(110;0.137)					AATTGTAGTCGTTGAAAAAAC	0.418000								Direct reversal of damage					7	85					0	0	1	0	0
RSPH1	89765	broad.mit.edu	37	21	43912900	43912900	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr21:43912900G>A	ENST00000291536.3	-	3	409	c.242C>T	c.(241-243)aCt>aTt	p.T81I	RSPH1_ENST00000398352.3_Missense_Mutation_p.T43I	NM_080860.2	NP_543136.1	Q8WYR4	RSPH1_HUMAN	radial spoke head 1 homolog (Chlamydomonas)	81					meiosis	cytosol|nucleus				large_intestine(7)|lung(2)|ovary(1)|prostate(1)|stomach(1)	12						ATATATAAAAGTGCCTTGACC	0.323000													6	128					0	0	1	0	0
IGSF11	152404	broad.mit.edu	37	3	118621617	118621617	+	Nonsense_Mutation	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:118621617G>C	ENST00000354673.2	-	9	1423	c.1043C>G	c.(1042-1044)tCa>tGa	p.S348*	IGSF11_ENST00000489689.1_Nonsense_Mutation_p.S325*|IGSF11_ENST00000491903.1_Nonsense_Mutation_p.S321*|IGSF11_ENST00000425327.2_Nonsense_Mutation_p.S348*|IGSF11_ENST00000441144.2_Nonsense_Mutation_p.S324*|IGSF11_ENST00000393775.2_Nonsense_Mutation_p.S349*	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	349					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GGCATTGCCTGAGTGGAAAGA	0.478000													6	198					0	0	1	0	0
SLC3A1	6519	broad.mit.edu	37	2	44547744	44547744	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr2:44547744C>T	ENST00000260649.6	+	10	2100	c.2024C>T	c.(2023-2025)tCc>tTc	p.S675F	SLC3A1_ENST00000409740.3_Missense_Mutation_p.S306F|SLC3A1_ENST00000409380.1_Missense_Mutation_p.S397F|PREPL_ENST00000409411.1_3'UTR|PREPL_ENST00000541738.1_3'UTR|PREPL_ENST00000409936.1_3'UTR|PREPL_ENST00000409957.1_3'UTR	NM_000341.3	NP_000332.2	Q07837	SLC31_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 1	675					carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(1)|skin(3)	26		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	GCATGCTATTCCAGTGTACTG	0.418000													9	68					0	0	1	0	0
IL37	27178	broad.mit.edu	37	2	113676262	113676262	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr2:113676262G>A	ENST00000263326.3	+	5	575	c.533G>A	c.(532-534)tGc>tAc	p.C178Y	IL37_ENST00000352179.3_Missense_Mutation_p.C157Y|IL37_ENST00000349806.3_Missense_Mutation_p.C117Y|IL37_ENST00000311328.2_Missense_Mutation_p.C152Y|IL37_ENST00000353225.3_Missense_Mutation_p.C138Y	NM_014439.3	NP_055254.2	Q9NZH6	IL37_HUMAN	interleukin 37	178					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(2)|skin(3)	19						TGGTTCATCTGCACCTCCTGC	0.493000													4	69					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3920783	3920783	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr17:3920783G>A	ENST00000381638.2	-	48	8007	c.7883C>T	c.(7882-7884)gCc>gTc	p.A2628V		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	2628							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						AGGCCACTCGGCGAGCAGGGA	0.582000													4	38					0	0	1	0	0
PWWP2B	170394	broad.mit.edu	37	10	134218307	134218307	+	Silent	SNP	A	A	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr10:134218307A>C	ENST00000305233.5	+	2	362	c.303A>C	c.(301-303)ccA>ccC	p.P101P	PWWP2B_ENST00000368609.4_Silent_p.P101P	NM_138499.3	NP_612508.3	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2B	101	Pro-rich.							p.P101P(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|urinary_tract(1)	9		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		GCCCCGAGCCACCCCCGCCCC	0.756000													6	11					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43305922	43305922	+	Silent	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr6:43305922G>C	ENST00000361428.2	-	10	5891	c.5814C>G	c.(5812-5814)ctC>ctG	p.L1938L	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1938					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TCTTGAGTTTGAGACTTCTGT	0.438000													9	185					0	0	1	0	0
BRPF3	27154	broad.mit.edu	37	6	36182028	36182028	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr6:36182028G>A	ENST00000357641.6	+	8	3107	c.2854G>A	c.(2854-2856)Gag>Aag	p.E952K	BRPF3_ENST00000339717.7_Intron|BRPF3_ENST00000543502.1_Intron|BRPF3_ENST00000443324.2_Intron|BRPF3_ENST00000534694.1_Intron|BRPF3_ENST00000534400.1_Missense_Mutation_p.E952K	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	952					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						GGAGAATGGCGAGGACCATGG	0.602000													9	79					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110763381	110763381	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr7:110763381G>A	ENST00000451085.1	+	4	1599	c.553G>A	c.(553-555)Gat>Aat	p.D185N	LRRN3_ENST00000308478.5_Missense_Mutation_p.D185N|IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000450877.1_Intron|LRRN3_ENST00000422987.3_Missense_Mutation_p.D185N|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000331762.3_Intron|IMMP2L_ENST00000452895.1_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	185						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		TAAGTGGTTTGATGCTCTTCC	0.378000													8	90					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100523442	100523442	+	Silent	SNP	G	G	A			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr8:100523442G>A	ENST00000358544.2	+	29	4521	c.4410G>A	c.(4408-4410)gaG>gaA	p.E1470E	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Silent_p.E1445E	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1470					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CAAGAAATGAGCGAAGAAGTT	0.373000													21	104					0	0	1	0	0
LMNA	4000	broad.mit.edu	37	1	156100425	156100425	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:156100425G>C	ENST00000368300.4	+	2	586	c.374G>C	c.(373-375)gGt>gCt	p.G125A	LMNA_ENST00000448611.2_Missense_Mutation_p.G13A|LMNA_ENST00000368301.2_Missense_Mutation_p.G125A|LMNA_ENST00000473598.2_Missense_Mutation_p.G26A|LMNA_ENST00000392353.3_Missense_Mutation_p.G44A|LMNA_ENST00000368297.1_Missense_Mutation_p.G44A|LMNA_ENST00000368299.3_Missense_Mutation_p.G125A|LMNA_ENST00000361308.4_Missense_Mutation_p.G125A|LMNA_ENST00000347559.2_Missense_Mutation_p.G125A	NM_170707.3	NP_733821.1	P02545	LMNA_HUMAN	lamin A/C	125	Coil 1B.|Interaction with MLIP.|Rod.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity			NS(1)|endometrium(1)|kidney(1)|lung(3)|ovary(4)	10	Hepatocellular(266;0.158)					AAGAAGGAGGGTGACCTGATA	0.567000									Werner syndrome;Hutchinson-Gilford Progeria Syndrome		OREG0013866	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	91					0	0	1	0	0
CACNG4	27092	broad.mit.edu	37	17	64961156	64961156	+	Silent	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr17:64961156C>T	ENST00000262138.3	+	1	131	c.129C>T	c.(127-129)ggC>ggT	p.G43G		NM_014405.3	NP_055220.1	Q9UBN1	CCG4_HUMAN	calcium channel, voltage-dependent, gamma subunit 4	43					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(3)	19	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			TCTGCAACGGCACCAACCTGA	0.692000													3	10					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114070207	114070207	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr3:114070207C>T	ENST00000462705.1	-	11	1320	c.499G>A	c.(499-501)Gtg>Atg	p.V167M	ZBTB20_ENST00000471418.1_Missense_Mutation_p.V167M|ZBTB20_ENST00000474710.1_Missense_Mutation_p.V240M|ZBTB20_ENST00000481632.1_Missense_Mutation_p.V167M|ZBTB20_ENST00000357258.3_Missense_Mutation_p.V167M|ZBTB20_ENST00000464560.1_Missense_Mutation_p.V167M|ZBTB20_ENST00000393785.2_Missense_Mutation_p.V167M	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	240	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		ATCCTGTCCACGCTGTGCTGT	0.662000													8	123					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173952700	173952702	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr1:173952700_173952702delCTT	ENST00000367696.2	-	4	797_799	c.446_448delAAG	c.(445-450)ggc>g	p.EG149del	RC3H1_ENST00000367694.2_In_Frame_Del_p.EG149del|RC3H1_ENST00000258349.4_In_Frame_Del_p.EG149del			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	149					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						CGAATCCTGCCTTCTTCTTCTAC	0.483													28	87	---	---	---	---					
TMEM131	23505	broad.mit.edu	37	2	98427639	98427639	+	Frame_Shift_Del	DEL	T	T	-			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr2:98427639delT	ENST00000186436.5	-	18	2148	c.1920delA	c.(1918-1920)aafs	p.K640fs		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	640						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						TCCCCTCTAATTTTTTTGCAG	0.393													7	272	---	---	---	---					
DBN1	1627	broad.mit.edu	37	5	176894605	176894605	+	Frame_Shift_Del	DEL	G	G	-			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr5:176894605delG	ENST00000292385.5	-	6	969	c.360delC	c.(358-360)gcfs	p.A120fs	DBN1_ENST00000393565.1_Frame_Shift_Del_p.A118fs|DBN1_ENST00000309007.5_Frame_Shift_Del_p.A118fs	NM_080881.2	NP_543157.1	Q16643	DREB_HUMAN	drebrin 1	118	ADF-H.				actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCACGCTGCTGGCGTTCACGA	0.677													2	4	---	---	---	---					
ZCCHC3	85364	broad.mit.edu	37	20	278688	278690	+	In_Frame_Del	DEL	CGG	CGG	-	rs63544660		TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr20:278688_278690delCGG	ENST00000382352.3	+	1	952_954	c.461_463delCGG	c.(460-465)ccg>c	p.PA154del		NM_033089.6	NP_149080.2	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	154							nucleic acid binding|zinc ion binding	p.A159delA(3)		endometrium(2)|large_intestine(1)|lung(3)|prostate(2)	8		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CAGGATGAgccggcggcggcggc	0.768													4	2	---	---	---	---					
SCAF4	57466	broad.mit.edu	37	21	33060662	33060663	+	Frame_Shift_Ins	INS	-	-	G			TCGA-P3-A6SW-01A-11D-A34J-08	TCGA-P3-A6SW-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2aa1f6c7-5def-4e59-b997-2cc47a32e7a5	8e2894fc-b325-49e8-afd3-b9c2b10ec1e2	g.chr21:33060662_33060663insG	ENST00000286835.7	-	16	2382_2383	c.2000_2001insC	c.(1999-2001)cccfs	p.P667fs	SCAF4_ENST00000399804.1_Frame_Shift_Ins_p.P667fs|SCAF4_ENST00000434667.3_Frame_Shift_Ins_p.P652fs	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	667						nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						CAGGAATAGGAGGGACAGGCAC	0.450													42	132	---	---	---	---					
