Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SP140	11262	broad.mit.edu	37	2	231159004	231159004	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:231159004C>T	ENST00000392045.3	+	21	2101	c.1987C>T	c.(1987-1989)Cct>Tct	p.P663S	SP140_ENST00000350136.5_Missense_Mutation_p.P532S|SP140_ENST00000486687.2_Missense_Mutation_p.P587S|SP140_ENST00000417495.3_Missense_Mutation_p.P549S|SP140_ENST00000343805.6_Missense_Mutation_p.P603S|SP140_ENST00000420434.3_Missense_Mutation_p.P636S	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	663					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P663S(1)		NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TCTGCCTGATCCTCCAAGAAT	0.363000													7	89					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32050096	32050096	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:32050096C>G	ENST00000375244.3	-	9	3654	c.3453G>C	c.(3451-3453)caG>caC	p.Q1151H	TNXB_ENST00000375247.2_Missense_Mutation_p.Q1151H			P22105	TENX_HUMAN	tenascin XB	1238	Fibronectin type-III 4.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TTGGGTCACTCTGAGGCACTA	0.572000													9	94					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1437283	1437283	+	Missense_Mutation	SNP	G	G	A	rs139292269	byFrequency	TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:1437283G>A	ENST00000345913.4	+	4	344	c.253G>A	c.(253-255)Gga>Aga	p.G85R	TPO_ENST00000349624.3_Missense_Mutation_p.G85R|TPO_ENST00000382201.3_Missense_Mutation_p.G85R|TPO_ENST00000382269.3_Missense_Mutation_p.G85R|TPO_ENST00000539820.1_Missense_Mutation_p.G85R|TPO_ENST00000337415.3_Missense_Mutation_p.G85R|TPO_ENST00000346956.3_Missense_Mutation_p.G85R|TPO_ENST00000382198.1_Missense_Mutation_p.G85R|TPO_ENST00000329066.4_Missense_Mutation_p.G85R|TPO_ENST00000497517.2_Intron	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	85					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCCAACAAGCGGAGTGATTGC	0.408000													12	89					0	0	1	0	0
USP40	55230	broad.mit.edu	37	2	234457817	234457817	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:234457817C>G	ENST00000251722.6	-	8	1013	c.896G>C	c.(895-897)gGt>gCt	p.G299A	USP40_ENST00000427112.2_Missense_Mutation_p.G299A|USP40_ENST00000450966.1_Missense_Mutation_p.G311A			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	299				CEQSELDDLEYIYDLFSVIIHKGGCYGGHYHVYIKDVDHLG N -> FFSFNQKMHNVCVNRRYGGSGMPLLRCGRCVGSAQP LSSVFR (in Ref. 4; AAH67300).	ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		GTAGCAGCCACCTTTGTGTAT	0.303000													3	22					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100366335	100366335	+	RNA	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:100366335C>T	ENST00000542585.1	+	0	5292				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000449052.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCTGAATCCTCTGAACCTGGG	0.622000													3	13					0	0	1	0	0
XIAP	331	broad.mit.edu	37	X	123019598	123019598	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:123019598G>C	ENST00000371199.3	+	2	385	c.86G>C	c.(85-87)aGa>aCa	p.R29T	XIAP_ENST00000434753.3_Missense_Mutation_p.R29T|XIAP_ENST00000468691.1_Intron|XIAP_ENST00000355640.3_Missense_Mutation_p.R29T	NM_001167.3	NP_001158.2	P98170	XIAP_HUMAN	X-linked inhibitor of apoptosis	29					anti-apoptosis|apoptosis|induction of apoptosis by intracellular signals|response to DNA damage stimulus	cytosol	caspase inhibitor activity|ligase activity|protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)	25						GAGTTTAATAGATTAAAAACT	0.368000									X-linked Lymphoproliferative syndrome				42	139					0	0	1	0	0
PNMA1	9240	broad.mit.edu	37	14	74180338	74180338	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:74180338G>A	ENST00000316836.3	-	1	790	c.5C>T	c.(4-6)gCg>gTg	p.A2V		NM_006029.4	NP_006020.4	Q8ND90	PNMA1_HUMAN	paraneoplastic Ma antigen 1	2					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|urinary_tract(2)	13				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)		cagtgtcatcgccattttctc	0.522000													4	106					0	0	1	0	0
PPP1R3C	5507	broad.mit.edu	37	10	93389933	93389933	+	Nonsense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr10:93389933G>T	ENST00000238994.5	-	2	789	c.705C>A	c.(703-705)tgC>tgA	p.C235*		NM_005398.5	NP_005389.1	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory subunit 3C	235	CBM21.|Interaction with EPM2A.						protein serine/threonine phosphatase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(1)	12		Colorectal(252;0.235)				GGTAAGAAATGCAGAACTCAA	0.408000													21	85					4.35082e-09	4.63281e-09	1	1	0
EIF4G3	8672	broad.mit.edu	37	1	21268505	21268505	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:21268505G>T	ENST00000602326.1	-	12	1575	c.992C>A	c.(991-993)cCt>cAt	p.P331H	EIF4G3_ENST00000374937.3_Missense_Mutation_p.P331H|EIF4G3_ENST00000400422.1_Missense_Mutation_p.P325H|EIF4G3_ENST00000374927.4_Missense_Mutation_p.P325H|EIF4G3_ENST00000374935.3_Intron|EIF4G3_ENST00000356916.3_Missense_Mutation_p.P336H|EIF4G3_ENST00000536266.1_5'UTR|EIF4G3_ENST00000264211.8_Missense_Mutation_p.P325H	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	325					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TGTTGGTAAAGGGTCTGATGT	0.383000													22	280					1.9806e-07	2.08325e-07	1	1	0
SLC44A2	57153	broad.mit.edu	37	19	10747142	10747142	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:10747142C>T	ENST00000586078.1	+	15	1486	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F	SLC44A2_ENST00000335757.5_Silent_p.F459F|SLC44A2_ENST00000407327.4_Silent_p.F457F	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	459					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	TGGCCAACTTCGTGCTGGCGC	0.647000													25	129					0	0	1	0	0
ECHDC2	55268	broad.mit.edu	37	1	53362207	53362207	+	Silent	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:53362207T>C	ENST00000536120.1	-	13	1543	c.726A>G	c.(724-726)aaA>aaG	p.K242K	ECHDC2_ENST00000371522.4_Silent_p.K288K|ECHDC2_ENST00000358358.5_Silent_p.K257K			Q86YB7	ECHD2_HUMAN	enoyl CoA hydratase domain containing 2	288					fatty acid metabolic process	mitochondrion	lyase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	12						TGCCAACAAATTTGGGAGTCC	0.502000													4	139					0	0	1	0	0
FOCAD	54914	broad.mit.edu	37	9	20986313	20986313	+	Silent	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:20986313C>G	ENST00000380249.1	+	42	5119	c.4755C>G	c.(4753-4755)gtC>gtG	p.V1585V	FOCAD_ENST00000605086.1_Silent_p.V1021V|FOCAD_ENST00000338382.6_Silent_p.V1585V	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	1585						integral to membrane	binding										CTGCCTTTGTCAAACTGTACT	0.413000													9	113					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141643780	141643780	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:141643780G>A	ENST00000389484.3	-	24	4862	c.3891C>T	c.(3889-3891)ttC>ttT	p.F1297F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1297					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AACTTTGATTGAAGTGAAAAT	0.333000										TSP Lung(27;0.18)			7	70					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237796974	237796974	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:237796974C>T	ENST00000366574.2	+	43	6969	c.6652C>T	c.(6652-6654)Ctc>Ttc	p.L2218F	RYR2_ENST00000542537.1_Missense_Mutation_p.L2202F|RYR2_ENST00000360064.6_Missense_Mutation_p.L2216F	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2218	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTTTGATCATCTCAGTTATTT	0.338000													6	106					0	0	1	0	0
CD109	135228	broad.mit.edu	37	6	74492437	74492437	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:74492437G>A	ENST00000437994.2	+	18	2495	c.2064G>A	c.(2062-2064)aaG>aaA	p.K688K	CD109_ENST00000422508.2_Silent_p.K611K|CD109_ENST00000287097.5_Silent_p.K688K	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	688	Bait region (approximate) (By similarity).					anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ATGTCCGAAAGCATTTTCCAG	0.348000													80	68					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12123724	12123724	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:12123724C>G	ENST00000379388.2	+	4	4028	c.3696C>G	c.(3694-3696)atC>atG	p.I1232M		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1232					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGCACAACATCCAAGTTCCAG	0.493000													6	57					0	0	1	0	0
RXFP3	51289	broad.mit.edu	37	5	33937219	33937219	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:33937219C>T	ENST00000330120.3	+	1	729	c.374C>T	c.(373-375)gCg>gTg	p.A125V		NM_016568.3	NP_057652.1	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	125						integral to plasma membrane	N-formyl peptide receptor activity			endometrium(4)|large_intestine(9)|lung(24)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)	42						ACCAACCTGGCGCTGACGGAC	0.582000													15	141					0	0	1	0	0
ATP1A1	476	broad.mit.edu	37	1	116943570	116943570	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:116943570G>C	ENST00000537345.1	+	19	3023	c.2660G>C	c.(2659-2661)cGa>cCa	p.R887P	ATP1A1_ENST00000369496.4_Missense_Mutation_p.R856P|ATP1A1_ENST00000295598.5_Missense_Mutation_p.R887P	NM_001160233.1	NP_001153705.1	P05023	AT1A1_HUMAN	ATPase, Na+/K+ transporting, alpha 1 polypeptide	887					ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			NS(2)|breast(2)|cervix(3)|endometrium(2)|kidney(5)|large_intestine(9)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TTGGGCCTCCGAGTGGACTGG	0.552000													15	60					0	0	1	0	0
TFAP2E	339488	broad.mit.edu	37	1	36054038	36054038	+	Missense_Mutation	SNP	C	C	T	rs148010311		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:36054038C>T	ENST00000373235.3	+	4	878	c.670C>T	c.(670-672)Cgg>Tgg	p.R224W		NM_178548.3	NP_848643.2	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)	224						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)	2		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				CGTGCCCGGCCGGCTTTCACT	0.647000													9	179					0	0	1	0	0
PHC2	1912	broad.mit.edu	37	1	33837995	33837995	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:33837995C>T	ENST00000257118.5	-	2	281	c.228G>A	c.(226-228)caG>caA	p.Q76Q	PHC2_ENST00000419414.2_Silent_p.Q76Q|PHC2_ENST00000431992.1_Silent_p.Q76Q|PHC2_ENST00000373416.1_5'UTR	NM_198040.2	NP_932157.1	Q8IXK0	PHC2_HUMAN	polyhomeotic homolog 2 (Drosophila)	76	Gln-rich.				multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			autonomic_ganglia(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CGTACATCTGCTGCAGGTACT	0.672000													6	26					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25936334	25936334	+	Nonsense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:25936334C>G	ENST00000398988.3	+	18	2304	c.1859C>G	c.(1858-1860)tCa>tGa	p.S620*	KSR1_ENST00000319524.6_Nonsense_Mutation_p.S757*|KSR1_ENST00000509603.2_Nonsense_Mutation_p.S735*|KSR1_ENST00000268763.6_Nonsense_Mutation_p.S620*	NM_014238.1	NP_055053.1	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	755	Protein kinase.				Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		TTTGGGATCTCAGGCGTGGTC	0.542000													19	195					0	0	1	0	0
HDX	139324	broad.mit.edu	37	X	83724155	83724155	+	Silent	SNP	G	G	A	rs149996033		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:83724155G>A	ENST00000297977.5	-	3	687	c.576C>T	c.(574-576)caC>caT	p.H192H	HDX_ENST00000373177.2_Silent_p.H192H|HDX_ENST00000506585.2_Silent_p.H134H	NM_001177479.1|NM_144657.4	NP_001170950.1|NP_653258.2	Q7Z353	HDX_HUMAN	highly divergent homeobox	192						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(12)|liver(1)|lung(19)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						TTTTCTTTGCGTGATTGAATA	0.388000													31	163					0	0	1	0	0
FBXO33	254170	broad.mit.edu	37	14	39871066	39871066	+	Splice_Site	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:39871066C>T	ENST00000298097.7	-	3	1048		c.e3-1		FBXO33_ENST00000554190.1_Intron	NM_203301.3	NP_976046.1	Q7Z6M2	FBX33_HUMAN	F-box protein 33											endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|urinary_tract(1)	9	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00121)|Epithelial(34;0.169)	GBM - Glioblastoma multiforme(112;0.0425)		TTGCTGAATTCTATAAGGAAA	0.368000													17	78					0	0	1	0	0
ZBTB44	29068	broad.mit.edu	37	11	130131646	130131646	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:130131646G>C	ENST00000525842.1	-	2	490	c.123C>G	c.(121-123)atC>atG	p.I41M	ZBTB44_ENST00000530205.1_Missense_Mutation_p.I41M|ZBTB44_ENST00000397753.1_Missense_Mutation_p.I41M|ZBTB44_ENST00000357899.4_Missense_Mutation_p.I41M	NM_014155.4	NP_054874.3	Q8NCP5	ZBT44_HUMAN	zinc finger and BTB domain containing 44	41	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	15	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0192)|Lung(977;0.235)		GTGCCCGGAAGATTTTGTCCT	0.453000													4	182					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278688	36278688	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:36278688G>A	ENST00000007510.4	+	21	3365	c.3221G>A	c.(3220-3222)gGc>gAc	p.G1074D	ARHGAP33_ENST00000314737.5_Missense_Mutation_p.G913D|ARHGAP33_ENST00000378944.5_Missense_Mutation_p.G910D			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1074					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						AGCTCTCTGGGCCCCCCTGCA	0.662000													8	69					0	0	1	0	0
GPR160	26996	broad.mit.edu	37	3	169802120	169802120	+	Silent	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr3:169802120T>C	ENST00000355897.5	+	4	968	c.360T>C	c.(358-360)taT>taC	p.Y120Y		NM_014373.2	NP_055188.1	Q9UJ42	GP160_HUMAN	G protein-coupled receptor 160	120						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.Y120*(1)		breast(1)|cervix(1)|kidney(1)|large_intestine(3)|lung(2)	8	all_cancers(22;3.26e-22)|all_epithelial(15;5.71e-27)|all_lung(20;8.41e-17)|Lung NSC(18;3.49e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GTATAGATTATTGCCTGAATT	0.294000													14	140					0	0	1	0	0
CYP26A1	1592	broad.mit.edu	37	10	94834728	94834728	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr10:94834728G>A	ENST00000371531.1	+	3	778	c.400G>A	c.(400-402)Gac>Aac	p.D134N	CYP26A1_ENST00000224356.4_Missense_Mutation_p.D203N|CYP26A1_ENST00000394139.1_Missense_Mutation_p.D134N	NM_057157.2	NP_476498.1	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A, polypeptide 1	203					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16		Colorectal(252;0.122)				ACTGGCGGGCGACGGGGACTC	0.657000													15	83					0	0	1	0	0
TECPR1	25851	broad.mit.edu	37	7	97851780	97851780	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:97851780G>A	ENST00000447648.2	-	22	3281	c.2982C>T	c.(2980-2982)atC>atT	p.I994I	TECPR1_ENST00000479975.1_5'UTR|TECPR1_ENST00000379795.3_Silent_p.I996I			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	994						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AGCAGGCCCCGATGGAGATGG	0.711000													5	9					0	0	1	0	0
ABCF3	55324	broad.mit.edu	37	3	183909041	183909041	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr3:183909041G>T	ENST00000429586.2	+	16	1752	c.1567G>T	c.(1567-1569)Gtg>Ttg	p.V523L	ABCF3_ENST00000292808.5_Missense_Mutation_p.V517L|EIF2B5_ENST00000444495.1_Intron	NM_018358.2	NP_060828.2	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 3	523	ABC transporter 2.						ATP binding|ATPase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(20)|ovary(3)|prostate(5)|upper_aerodigestive_tract(1)	39	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCGCATCTGTGTGGTAAGGCT	0.537000													23	273					3.83957e-06	4.00197e-06	1	1	0
FXR1	8087	broad.mit.edu	37	3	180669130	180669130	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr3:180669130G>A	ENST00000357559.4	+	8	1059	c.675G>A	c.(673-675)gtG>gtA	p.V225V	FXR1_ENST00000491062.1_Silent_p.V176V|FXR1_ENST00000480918.1_Silent_p.V212V|FXR1_ENST00000445140.2_Silent_p.V225V|FXR1_ENST00000305586.7_Silent_p.V140V|FXR1_ENST00000468861.1_Silent_p.V140V	NM_001013438.2|NM_005087.3	NP_001013456.1|NP_005078.2	P51114	FXR1_HUMAN	fragile X mental retardation, autosomal homolog 1	225	KH 1.				apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(3)|endometrium(4)|large_intestine(5)|lung(12)|skin(2)	26	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			AATTTGTTGTGAGAGAAGATT	0.363000													11	126					0	0	1	0	0
LYPLA2	11313	broad.mit.edu	37	1	24119250	24119250	+	Splice_Site	SNP	G	G	A	rs2232978		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:24119250G>A	ENST00000374514.3	+	2	385	c.78_splice	c.e2+1	p.A26_splice	LYPLA2_ENST00000495365.1_3'UTR|LYPLA2_ENST00000374503.3_Splice_Site_p.A26_splice|LYPLA2_ENST00000400061.1_Splice_Site_p.A26_splice|LYPLA2_ENST00000374502.3_Splice_Site_p.A26_splice|LYPLA2_ENST00000374505.2_Splice_Site_p.A26_splice	NM_007260.2	NP_009191.1	O95372	LYPA2_HUMAN	lysophospholipase II	26					fatty acid metabolic process	cytoplasm	hydrolase activity	p.A26A(1)		endometrium(3)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		AAACGGCCGCGGTAAGGGTCC	0.642000													17	142					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628299	29628299	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr20:29628299A>G	ENST00000278882.3	+	6	681	c.301A>G	c.(301-303)Agt>Ggt	p.S101G	FRG1B_ENST00000358464.4_Missense_Mutation_p.S101G|FRG1B_ENST00000439954.2_Missense_Mutation_p.S106G																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AGAAGCAAAAAGTAAAACAGC	0.363000													4	116					0	0	1	0	0
SUV420H2	84787	broad.mit.edu	37	19	55858809	55858809	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:55858809G>A	ENST00000255613.3	+	9	1629	c.1381G>A	c.(1381-1383)Gag>Aag	p.E461K		NM_032701.3	NP_116090.2	Q86Y97	SV422_HUMAN	suppressor of variegation 4-20 homolog 2 (Drosophila)	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)	4	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CGGCGGTGAAGAGCTGTGACA	0.672000													5	20					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55356397	55356397	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:55356397C>T	ENST00000524622.1	-	7	1532	c.871G>A	c.(871-873)Gag>Aag	p.E291K	TESPA1_ENST00000316577.8_Missense_Mutation_p.E429K|TESPA1_ENST00000532804.1_Missense_Mutation_p.E291K|TESPA1_ENST00000531122.1_Missense_Mutation_p.E291K|TESPA1_ENST00000449076.1_Missense_Mutation_p.E429K	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	429																	CAGAAAGTCTCATCCTTGGCT	0.507000													32	164					0	0	1	0	0
DAP3	7818	broad.mit.edu	37	1	155699069	155699069	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:155699069C>A	ENST00000368336.5	+	9	879	c.755C>A	c.(754-756)tCt>tAt	p.S252Y	DAP3_ENST00000471214.1_3'UTR|DAP3_ENST00000343043.3_Missense_Mutation_p.S252Y|DAP3_ENST00000421487.2_Missense_Mutation_p.S218Y|DAP3_ENST00000535183.1_Missense_Mutation_p.S211Y|MSTO1_ENST00000452804.2_Intron|MSTO1_ENST00000538143.1_Intron	NM_001199849.1|NM_004632.3	NP_001186778.1|NP_004623.1	P51398	RT29_HUMAN	death associated protein 3	252					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	24	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					AGGCAAAGTTCTTTGGGTATG	0.473000													28	132					1.55811e-20	1.7011e-20	1	1	0
TMEM38A	79041	broad.mit.edu	37	19	16799014	16799014	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:16799014C>G	ENST00000187762.2	+	6	823	c.732C>G	c.(730-732)atC>atG	p.I244M		NM_024074.1	NP_076979.1	Q9H6F2	TM38A_HUMAN	transmembrane protein 38A	244						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)	15						AGGGCTACATCTGCCCCGTGC	0.632000													42	335					0	0	1	0	0
SLC12A4	6560	broad.mit.edu	37	16	67986121	67986121	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr16:67986121C>A	ENST00000422611.2	-	6	928	c.889G>T	c.(889-891)Ggc>Tgc	p.G297C	SLC12A4_ENST00000541864.2_Missense_Mutation_p.G264C|SLC12A4_ENST00000537830.2_Missense_Mutation_p.G289C|SLC12A4_ENST00000338335.3_Missense_Mutation_p.G295C|SLC12A4_ENST00000576616.1_Missense_Mutation_p.G295C|SLC12A4_ENST00000572037.1_Missense_Mutation_p.G247C|SLC12A4_ENST00000316341.3_Missense_Mutation_p.G295C	NM_001145962.1	NP_001139434.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	295					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GACTTTATGCCCCCAGCATAG	0.498000													9	53					3.09899e-07	3.2497e-07	1	1	0
MIR493	574450	broad.mit.edu	37	14	101335439	101335439	+	RNA	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:101335439G>A	ENST00000385254.1	+	0	43					NR_030172.1																						tcattcattcgtttgcacatt	0.587000													10	56					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160245892	160245892	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:160245892C>G	ENST00000392783.2	-	21	3675	c.3180G>C	c.(3178-3180)aaG>aaC	p.K1060N	AC008277.1_ENST00000420020.1_RNA|BAZ2B_ENST00000392782.1_Missense_Mutation_p.K1024N|BAZ2B_ENST00000343439.5_Missense_Mutation_p.K960N|BAZ2B_ENST00000355831.2_Missense_Mutation_p.K1026N	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1060	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						CATTAGGCTTCTTTAGTTCCT	0.338000													31	186					0	0	1	0	0
LMBRD1	55788	broad.mit.edu	37	6	70428941	70428941	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:70428941C>T	ENST00000370577.3	-	8	898	c.669G>A	c.(667-669)ctG>ctA	p.L223L	LMBRD1_ENST00000370570.1_Silent_p.L150L	NM_018368.3	NP_060838.3	Q9NUN5	LMBD1_HUMAN	LMBR1 domain containing 1	223					interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	31						TGCCTTTTATCAGATTTAAAG	0.313000													10	63					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15937233	15937233	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:15937233C>A	ENST00000504595.1	+	4	1895	c.1414C>A	c.(1414-1416)Cgc>Agc	p.R472S	FBXL7_ENST00000329673.7_Missense_Mutation_p.R460S|FBXL7_ENST00000510662.1_Missense_Mutation_p.R425S	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	472					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GGAGGCCCTGCGCTTTGTCAA	0.592000													9	26					1.12685e-05	1.17097e-05	1	1	0
MED1	5469	broad.mit.edu	37	17	37566455	37566455	+	Silent	SNP	G	G	A	rs148664556	byFrequency	TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:37566455G>A	ENST00000300651.6	-	17	2242	c.2019C>T	c.(2017-2019)tcC>tcT	p.S673S	MED1_ENST00000394287.3_Intron	NM_004774.3	NP_004765.2	Q15648	MED1_HUMAN	mediator complex subunit 1	673	Interaction with ESR1.|Interaction with GATA1 (By similarity).|Interaction with PPARGC1A and THRA.|Interaction with VDR.			S -> F (in Ref. 9; AAC41736).	androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(1)|breast(2)|cervix(3)|kidney(3)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(7)|urinary_tract(1)	59		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		GGGGTGAGCCGGAAGAGGAGT	0.473000										HNSCC(31;0.082)			24	134					0	0	1	0	0
GPR52	9293	broad.mit.edu	37	1	174417406	174417406	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:174417406C>G	ENST00000367685.2	+	1	195	c.157C>G	c.(157-159)Ctg>Gtg	p.L53V	RABGAP1L_ENST00000367689.3_Intron|RABGAP1L_ENST00000251507.4_Intron|RABGAP1L_ENST00000357444.6_Intron	NM_005684.4	NP_005675.3	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	53						integral to plasma membrane	G-protein coupled receptor activity			breast(3)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|prostate(1)|skin(2)	20						GCTGACATTTCTGATCATTGC	0.443000													9	115					0	0	1	0	0
FBXL6	26233	broad.mit.edu	37	8	145580332	145580332	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr8:145580332G>A	ENST00000331890.5	-	6	985	c.921C>T	c.(919-921)acC>acT	p.T307T	FBXL6_ENST00000455319.2_Silent_p.T301T|FBXL6_ENST00000526524.1_5'UTR	NM_012162.2	NP_036294.1	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6	307					proteolysis		ubiquitin-protein ligase activity			endometrium(1)|lung(3)|ovary(1)	5	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			GGTTGATGCCGGTGCTCACCT	0.657000													42	71					0	0	1	0	0
TRBV29-1	28558	broad.mit.edu	37	7	142448589	142448589	+	RNA	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:142448589C>T	ENST00000422143.2	+	0	250																											TGACACTGATCGCAACTGCAA	0.507000													7	51					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86887271	86887271	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:86887271G>A	ENST00000373119.4	+	7	1531	c.1386G>A	c.(1384-1386)atG>atA	p.M462I	KLHL4_ENST00000373114.4_Missense_Mutation_p.M462I	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	462						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						TTGGCACCATGAATGGCCGTA	0.393000													10	71					0	0	1	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160274813	160274813	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr4:160274813G>A	ENST00000264431.4	+	22	4202	c.3783G>A	c.(3781-3783)caG>caA	p.Q1261Q		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1261					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		ATAATATACAGACGATCCAGC	0.527000													43	69					0	0	1	0	0
CFC1	55997	broad.mit.edu	37	2	131356270	131356270	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:131356270G>A	ENST00000259216.4	-	3	454	c.192C>T	c.(190-192)agC>agT	p.S64S		NM_032545.3	NP_115934.1	P0CG37	CFC1_HUMAN	cripto, FRL-1, cryptic family 1	64					determination of left/right symmetry|gastrulation	anchored to membrane|extracellular region|plasma membrane				endometrium(1)|lung(4)	5	Colorectal(110;0.1)					AGCCCTCGGCGCTCCCAGTCA	0.622000													10	180					0	0	1	0	0
LDHAL6A	160287	broad.mit.edu	37	11	18487234	18487234	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:18487234C>T	ENST00000280706.2	+	3	1092	c.295C>T	c.(295-297)Cgc>Tgc	p.R99C	LDHAL6A_ENST00000396213.3_Missense_Mutation_p.R99C	NM_144972.4	NP_659409.2	Q6ZMR3	LDH6A_HUMAN	lactate dehydrogenase A-like 6A	99					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity			large_intestine(3)|lung(9)|urinary_tract(1)	13					NADH(DB00157)	AGCAGGTGCACGCCAGAAAAA	0.388000													16	99					0	0	1	0	0
TPH2	121278	broad.mit.edu	37	12	72425055	72425055	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:72425055G>A	ENST00000333850.3	+	10	1323	c.1182G>A	c.(1180-1182)aaG>aaA	p.K394K		NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	394					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	TTTCTGACAAGGCATGTGTGA	0.413000													16	133					0	0	1	0	0
NT5DC1	221294	broad.mit.edu	37	6	116422175	116422175	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:116422175G>C	ENST00000319550.4	+	1	164	c.82G>C	c.(82-84)Gag>Cag	p.E28Q		NM_152729.2	NP_689942.2	Q5TFE4	NT5D1_HUMAN	5'-nucleotidase domain containing 1	28							hydrolase activity|metal ion binding			large_intestine(2)|lung(2)|prostate(2)|skin(1)|stomach(1)	8		all_cancers(87;0.00367)|all_epithelial(87;0.00449)|Colorectal(196;0.0469)		all cancers(137;0.0327)|OV - Ovarian serous cystadenocarcinoma(136;0.0445)|GBM - Glioblastoma multiforme(226;0.0719)|Epithelial(106;0.112)		CAACCTGCCCGAGAGCGCCCC	0.692000													5	34					0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72410572	72410572	+	Silent	SNP	A	A	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:72410572A>G	ENST00000359373.5	-	17	3179	c.2328T>C	c.(2326-2328)ctT>ctC	p.L776L	ARAP1_ENST00000455638.2_Silent_p.L776L|ARAP1_ENST00000393609.3_Silent_p.L776L|ARAP1_ENST00000495878.1_5'UTR|ARAP1_ENST00000429686.1_Silent_p.L470L|ARAP1_ENST00000426523.1_Silent_p.L531L|ARAP1_ENST00000393605.3_Silent_p.L536L|ARAP1_ENST00000334211.8_Silent_p.L531L			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	776	PH 3.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						CCCCGTCACCAAGGACACACC	0.632000													9	28					0	0	1	0	0
SULF2	55959	broad.mit.edu	37	20	46305857	46305857	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr20:46305857C>T	ENST00000359930.4	-	9	2066	c.1215G>A	c.(1213-1215)atG>atA	p.M405I	SULF2_ENST00000467815.1_Missense_Mutation_p.M405I|SULF2_ENST00000484875.1_Missense_Mutation_p.M405I|SULF2_ENST00000361612.4_Missense_Mutation_p.M405I	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	405					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						GCCAGACCCTCATCTTCTTTT	0.617000													18	90					0	0	1	0	0
NR2E1	7101	broad.mit.edu	37	6	108497868	108497868	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:108497868G>A	ENST00000368986.4	+	4	1129	c.421G>A	c.(421-423)Ggc>Agc	p.G141S	NR2E1_ENST00000484978.1_3'UTR|NR2E1_ENST00000368983.3_Missense_Mutation_p.G178S	NM_003269.3	NP_003260.1	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	141					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(16)|prostate(1)|skin(3)	30		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		GGAGCCGCACGGCCTGGAGCT	0.716000													3	10					0	0	1	0	0
ACAD8	27034	broad.mit.edu	37	11	134129581	134129581	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:134129581C>T	ENST00000281182.4	+	6	753	c.647C>T	c.(646-648)tCa>tTa	p.S216L	ACAD8_ENST00000524547.1_3'UTR|ACAD8_ENST00000374752.4_Missense_Mutation_p.S89L|ACAD8_ENST00000537423.1_Missense_Mutation_p.S139L|ACAD8_ENST00000543332.1_Missense_Mutation_p.S118L	NM_014384.2	NP_055199.1	Q9UKU7	ACAD8_HUMAN	acyl-CoA dehydrogenase family, member 8	216					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		AAGGGCATCTCATGCATAGTT	0.532000													21	106					0	0	1	0	0
PATZ1	23598	broad.mit.edu	37	22	31731763	31731763	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:31731763C>T	ENST00000266269.5	-	3	2051	c.1422G>A	c.(1420-1422)ggG>ggA	p.G474G	PATZ1_ENST00000405309.3_Silent_p.G474G|PATZ1_ENST00000351933.4_Silent_p.G474G|RP3-400N23.6_ENST00000451161.1_RNA|RP3-400N23.6_ENST00000440456.1_RNA	NM_014323.2	NP_055138.2	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	474					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						GCAAGTACTTCCCACACACCT	0.567000													7	107					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18688178	18688178	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:18688178A>G	ENST00000406451.3	+	11	1480	c.1330A>G	c.(1330-1332)Aga>Gga	p.R444G	HDAC9_ENST00000441542.2_Missense_Mutation_p.R447G|HDAC9_ENST00000406072.1_Missense_Mutation_p.R431G|HDAC9_ENST00000524023.1_Missense_Mutation_p.R367G|HDAC9_ENST00000432645.2_Missense_Mutation_p.R444G|HDAC9_ENST00000405010.3_Missense_Mutation_p.R444G|HDAC9_ENST00000401921.1_Missense_Mutation_p.R403G|HDAC9_ENST00000417496.2_Missense_Mutation_p.R442G|HDAC9_ENST00000456174.2_Missense_Mutation_p.R416G|HDAC9_ENST00000428307.2_Missense_Mutation_p.R400G	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	444					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	GCCCCGTCACAGACCCCTGAA	0.498000													14	83					0	0	1	0	0
PRR23B	389151	broad.mit.edu	37	3	138739189	138739189	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr3:138739189C>T	ENST00000329447.5	-	1	579	c.315G>A	c.(313-315)ctG>ctA	p.L105L	MRPS22_ENST00000495075.1_Intron	NM_001013650.2	NP_001013672.1	Q6ZRT6	PR23B_HUMAN	proline rich 23B	105										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CGACGGAGCTCAGGAGGACCT	0.652000													8	80					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039231	11039231	+	RNA	SNP	A	A	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr21:11039231A>G	ENST00000470054.1	-	0	972									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTCTTTGGATACCACTGTTTT	0.408000													11	504					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129148458	129148458	+	Silent	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:129148458C>A	ENST00000540052.1	+	3	1754	c.1710C>A	c.(1708-1710)gcC>gcA	p.A570A	BCORL1_ENST00000359304.2_Silent_p.A570A|BCORL1_ENST00000218147.7_Silent_p.A570A|BCORL1_ENST00000303743.5_Silent_p.A570A	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	570	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						TGCTGCCAGCCCCCAGTGGGA	0.617000													24	83					1.10513e-12	1.18776e-12	1	1	0
ATP2C2	9914	broad.mit.edu	37	16	84472848	84472848	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr16:84472848G>A	ENST00000416219.2	+	12	1152	c.1063G>A	c.(1063-1065)Gcc>Acc	p.A355T	ATP2C2_ENST00000262429.4_Missense_Mutation_p.A355T|ATP2C2_ENST00000420010.2_3'UTR			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	355					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						GCTGCGGATGGCCAAGAAGCG	0.567000													17	88					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40161822	40161822	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr20:40161822C>T	ENST00000373233.3	-	3	598	c.421G>A	c.(421-423)Gag>Aag	p.E141K	CHD6_ENST00000309279.7_Missense_Mutation_p.E141K|CHD6_ENST00000373222.3_Missense_Mutation_p.E176K	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	141	Lys-rich.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TCCTTGTGCTCCTTGGCCTTC	0.572000													9	330					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197657782	197657782	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:197657782C>T	ENST00000263956.3	-	3	398	c.309G>A	c.(307-309)gaG>gaA	p.E103E	GTF3C3_ENST00000409364.3_Silent_p.E103E	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	103	Glu-rich.					transcription factor TFIIIC complex	DNA binding|protein binding	p.E103E(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						cctcctcctcctcttcttcct	0.468000													4	109					0	0	1	0	0
PKIG	11142	broad.mit.edu	37	20	43243305	43243305	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr20:43243305G>A	ENST00000372889.1	+	5	693	c.108G>A	c.(106-108)agG>agA	p.R36R	PKIG_ENST00000372887.1_Silent_p.R36R|PKIG_ENST00000372882.3_Silent_p.R36R|PKIG_ENST00000372891.3_Silent_p.R36R|PKIG_ENST00000349959.3_Silent_p.R36R|PKIG_ENST00000372894.3_Silent_p.R36R|Z97053.1_ENST00000597250.1_Intron|PKIG_ENST00000372892.3_Silent_p.R36R|PKIG_ENST00000372886.1_Silent_p.R36R|PKIG_ENST00000477390.1_3'UTR			Q9Y2B9	IPKG_HUMAN	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	36							cAMP-dependent protein kinase inhibitor activity|protein binding			breast(1)|urinary_tract(1)	2		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.001)|COAD - Colon adenocarcinoma(18;0.00189)			TGAGCGTGAGGAAGCTGGCTG	0.642000													10	61					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28541039	28541039	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:28541039C>T	ENST00000452236.2	-	4	3244	c.2627G>A	c.(2626-2628)cGa>cAa	p.R876Q		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	876					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ctgaatacgtcgagctatggt	0.383000													28	151					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83712013	83712013	+	Silent	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr16:83712013G>T	ENST00000566620.1	+	10	1775	c.1485G>T	c.(1483-1485)gtG>gtT	p.V495V	CDH13_ENST00000268613.10_Silent_p.V542V|CDH13_ENST00000428848.3_Silent_p.V456V	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	495	Cadherin 4.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TGGGCAGCGTGCTGCTGACAG	0.617000													10	52					2.17888e-05	2.2574e-05	1	1	0
SEZ6L	23544	broad.mit.edu	37	22	26688618	26688618	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:26688618C>A	ENST00000529632.2	+	2	537	c.341C>A	c.(340-342)cCc>cAc	p.P114H	SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000343706.4_Missense_Mutation_p.P114H|SEZ6L_ENST00000404234.3_Missense_Mutation_p.P114H|SEZ6L_ENST00000360929.3_Missense_Mutation_p.P114H|SEZ6L_ENST00000248933.6_Missense_Mutation_p.P114H|SEZ6L_ENST00000403121.1_5'UTR	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	114						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CACGCCTTGCCCCCCAAGAAG	0.652000													5	21					0.014758	0.014758	1	1	0
FCGBP	8857	broad.mit.edu	37	19	40433288	40433288	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:40433288C>T	ENST00000221347.6	-	2	988	c.981G>A	c.(979-981)gtG>gtA	p.V327V		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	327	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGTCATAAGTCACTTCATTCC	0.567000													9	64					0	0	1	0	0
PHLDA2	7262	broad.mit.edu	37	11	2950497	2950497	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:2950497G>A	ENST00000314222.4	-	1	188	c.98C>T	c.(97-99)tCc>tTc	p.S33F		NM_003311.3	NP_003302.1	Q53GA4	PHLA2_HUMAN	pleckstrin homology-like domain, family A, member 2	33	PH.				apoptosis	cytoplasm|membrane				central_nervous_system(1)	1		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGGCGGTCGGAGGTGAGCAC	0.667000													6	21					0	0	1	0	0
PLAA	9373	broad.mit.edu	37	9	26910414	26910414	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:26910414C>T	ENST00000397292.3	-	12	1996	c.1579G>A	c.(1579-1581)Gca>Aca	p.A527T	PLAA_ENST00000520884.1_Missense_Mutation_p.A527T	NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	527					phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		GTTTTAGATGCAGCTGATCGG	0.303000													10	134					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30704565	30704565	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr8:30704565C>G	ENST00000256246.2	-	1	2043	c.1969G>C	c.(1969-1971)Gaa>Caa	p.E657Q		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	657										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TGAAATGATTCTTGTGATTTA	0.284000													4	65					0	0	1	0	0
HIST2H2AC	8338	broad.mit.edu	37	1	149858590	149858590	+	Silent	SNP	T	T	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:149858590T>A	ENST00000331380.2	+	1	66	c.66T>A	c.(64-66)gcT>gcA	p.A22A		NM_003517.2	NP_003508.1	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	22					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|ovary(1)|skin(1)	20	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CGTCCCGCGCTGGCCTCCAGT	0.657000													41	137					0	0	1	0	0
BTN1A1	696	broad.mit.edu	37	6	26508294	26508294	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:26508294A>G	ENST00000244513.6	+	6	952	c.886A>G	c.(886-888)Aaa>Gaa	p.K296E		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	296	B30.2/SPRY.					extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						TGCAGAATGGAAAAAGGCTAC	0.403000													16	157					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72038709	72038709	+	Missense_Mutation	SNP	T	T	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:72038709T>G	ENST00000378743.3	-	4	1585	c.1227A>C	c.(1225-1227)caA>caC	p.Q409H		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	409					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						TTTTAACTTTTTGCTGTACAG	0.323000													44	70					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55260487	55260487	+	Nonsense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:55260487C>G	ENST00000275493.2	+	22	2831	c.2654C>G	c.(2653-2655)tCa>tGa	p.S885*	EGFR_ENST00000455089.1_Nonsense_Mutation_p.S840*|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000454757.2_Nonsense_Mutation_p.S832*	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	885	Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GCATTGGAATCAATTTTACAC	0.438000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			9	76					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111689164	111689164	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:111689164C>T	ENST00000435970.1	-	16	6409	c.5593G>A	c.(5593-5595)Gac>Aac	p.D1865N	REV3L_ENST00000368805.1_Missense_Mutation_p.D1943N|REV3L_ENST00000358835.3_Missense_Mutation_p.D1943N|REV3L_ENST00000368802.3_Missense_Mutation_p.D1943N			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1943	Mediates interaction with MAD2L2.				DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AAGGAAAAGTCTCCCTCAAAC	0.458000								DNA polymerases (catalytic subunits)					15	75					0	0	1	0	0
CMC4	100272147	broad.mit.edu	37	X	154290185	154290185	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:154290185G>T	ENST00000369484.3	-	3	818	c.140C>A	c.(139-141)tCt>tAt	p.S47Y	CMC4_ENST00000369479.1_Missense_Mutation_p.S47Y	NM_001018024.2	NP_001018024.1			C-x(9)-C motif containing 4																		ACAGACGACAGATCTTCCCTT	0.443000													23	145					5.35356e-11	5.7182e-11	1	1	0
SACS	26278	broad.mit.edu	37	13	23911462	23911462	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr13:23911462T>C	ENST00000382298.3	-	10	7141	c.6553A>G	c.(6553-6555)Agt>Ggt	p.S2185G	SACS_ENST00000382292.3_Missense_Mutation_p.S2185G|SACS_ENST00000402364.1_Missense_Mutation_p.S1435G	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	2185					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAGATACTACTTCTTAGGCAT	0.358000													12	108					0	0	1	0	0
SMG6	23293	broad.mit.edu	37	17	2203590	2203590	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:2203590G>A	ENST00000544865.1	-	2	874	c.364C>T	c.(364-366)Cag>Tag	p.Q122*	SMG6_ENST00000263073.5_Nonsense_Mutation_p.Q153*			Q86US8	EST1A_HUMAN	SMG6 nonsense mediated mRNA decay factor	153	Interaction with telomeric DNA.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(10)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						CTAACAGTCTGCAAACGTCGT	0.468000													5	237					0	0	1	0	0
C7orf31	136895	broad.mit.edu	37	7	25191214	25191214	+	Splice_Site	SNP	C	C	G	rs140021144	byFrequency	TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:25191214C>G	ENST00000409280.1	-	7	993		c.e7+1		C7orf31_ENST00000283905.3_Splice_Site			Q8N865	CG031_HUMAN	chromosome 7 open reading frame 31											autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	14						AAGATACTTACATCATAATAT	0.323000													5	43					0	0	1	0	0
SEC23A	10484	broad.mit.edu	37	14	39530996	39530996	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:39530996C>T	ENST00000537403.1	-	9	2074	c.872G>A	c.(871-873)cGc>cAc	p.R291H	SEC23A_ENST00000545328.2_Missense_Mutation_p.R464H|SEC23A_ENST00000307712.6_Missense_Mutation_p.R493H|SEC23A_ENST00000536508.1_Missense_Mutation_p.R367H			Q15436	SC23A_HUMAN	Sec23 homolog A (S. cerevisiae)	493					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(1)	23	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		CACTCGGATGCGTCTCTGCCC	0.418000													16	84					0	0	1	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19277939	19277939	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr8:19277939C>T	ENST00000454498.2	-	7	2057	c.1044G>A	c.(1042-1044)aaG>aaA	p.K348K	CSGALNACT1_ENST00000311540.4_Silent_p.K348K|CSGALNACT1_ENST00000544602.1_Silent_p.K348K|CSGALNACT1_ENST00000518542.1_5'UTR|CSGALNACT1_ENST00000332246.6_Silent_p.K348K|CSGALNACT1_ENST00000522854.1_Silent_p.K348K	NM_001130518.1	NP_001123990.1	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 1	348					anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				Colorectal(111;0.182)		CGTTGCTTCCCTTCCAGAAGC	0.468000													28	93					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33292114	33292114	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:33292114C>G	ENST00000280979.4	+	13	5265	c.5095C>G	c.(5095-5097)Ctt>Gtt	p.L1699V	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1699	Ser-rich.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CGAGCTCTCTCTTTGCTCAGA	0.463000													17	121					0	0	1	0	0
LDOC1L	84247	broad.mit.edu	37	22	44893383	44893383	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:44893383C>T	ENST00000341255.3	-	2	563	c.54G>A	c.(52-54)ccG>ccA	p.P18P		NM_032287.2	NP_115663.2	Q6ICC9	LDOCL_HUMAN	leucine zipper, down-regulated in cancer 1-like	18										breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(3)|prostate(2)	11		Ovarian(80;0.024)|all_neural(38;0.0416)		LUAD - Lung adenocarcinoma(64;0.0161)		TCTGGGCATTCGGAGACGCTG	0.642000													7	53					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115219972	115219972	+	Splice_Site	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:115219972T>C	ENST00000369538.3	-	9	1522	c.1475_splice	c.e9+1	p.Y492_splice	AMPD1_ENST00000353928.6_Splice_Site_p.Y463_splice|AMPD1_ENST00000520113.2_Splice_Site_p.Y496_splice	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	463					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	AGGTACATACTAGATCCTGGG	0.507000													17	58					0	0	1	0	0
AKT1	207	broad.mit.edu	37	14	105238729	105238729	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:105238729G>A	ENST00000554581.1	-	11	2713	c.1233C>T	c.(1231-1233)atC>atT	p.I411I	AKT1_ENST00000407796.2_Silent_p.I411I|AKT1_ENST00000554192.1_Silent_p.I98I|AKT1_ENST00000402615.2_Silent_p.I411I|AKT1_ENST00000349310.3_Silent_p.I411I|AKT1_ENST00000544168.1_Silent_p.I349I|AKT1_ENST00000555458.1_Silent_p.I106I|AKT1_ENST00000554585.1_5'UTR|AKT1_ENST00000555528.1_Silent_p.I411I|AKT1_ENST00000554848.1_Silent_p.I411I			P31749	AKT1_HUMAN	v-akt murine thymoma viral oncogene homolog 1	411	AGC-kinase C-terminal.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			NS(3)|breast(97)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(7)|lung(10)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|thyroid(10)|urinary_tract(15)	176		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	GCTGCCACACGATACCGGCAA	0.617000		1	Mis		"""breast, colorectal, ovarian, NSCLC"""								21	139					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233482347	233482347	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:233482347C>G	ENST00000366624.3	+	2	1226	c.965C>G	c.(964-966)tCt>tGt	p.S322C	MLK4_ENST00000366623.3_Missense_Mutation_p.S322C	NM_032435.2	NP_115811.2																					TCCTTGTTTTCTAAGGGAAGC	0.478000													6	56					0	0	1	0	0
NUDC	10726	broad.mit.edu	37	1	27269257	27269257	+	Missense_Mutation	SNP	C	C	T	rs146502618		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:27269257C>T	ENST00000321265.5	+	5	659	c.536C>T	c.(535-537)tCg>tTg	p.S179L		NM_006600.3	NP_006591.1	Q9Y266	NUDC_HUMAN	nudC nuclear distribution protein	179	CS.				cell proliferation|cytokinesis|mitotic prometaphase|multicellular organismal development	cytosol|microtubule|nucleoplasm	protein binding			cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|ovary(1)	8				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;6.1e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.87e-29)|Colorectal(126;5.74e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000281)|STAD - Stomach adenocarcinoma(196;0.000604)|KIRC - Kidney renal clear cell carcinoma(1967;0.000739)|READ - Rectum adenocarcinoma(331;0.0421)		CAGACCCTGTCGGAGCTGGAC	0.577000													4	66					0	0	1	0	0
NUDT18	79873	broad.mit.edu	37	8	21965084	21965084	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr8:21965084G>A	ENST00000309188.6	-	5	817	c.699C>T	c.(697-699)gcC>gcT	p.A233A	NUDT18_ENST00000522405.1_Silent_p.A156A|NUDT18_ENST00000521807.2_3'UTR	NM_024815.3	NP_079091.3	Q6ZVK8	NUD18_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 18	233							hydrolase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|lung(2)	4				Colorectal(74;0.00185)|COAD - Colon adenocarcinoma(73;0.0608)|READ - Rectum adenocarcinoma(5;0.0986)		GCCGCAGGACGGCCATCTTCA	0.607000													36	49					0	0	1	0	0
OR10V1	390201	broad.mit.edu	37	11	59481275	59481275	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:59481275C>T	ENST00000307552.2	-	1	62	c.44G>A	c.(43-45)cGt>cAt	p.R15H	STX3_ENST00000300150.7_Intron	NM_001005324.1	NP_001005324.1	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V, member 1	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|liver(1)|lung(10)|skin(1)	16						TGAGAATGGACGAAAGAAAAA	0.438000													35	30					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47372995	47372995	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:47372995G>A	ENST00000399249.2	-	2	141	c.87C>T	c.(85-87)ttC>ttT	p.F29F	MYBPC3_ENST00000545968.1_Silent_p.F29F|MYBPC3_ENST00000256993.4_Silent_p.F29F			Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	29					cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		TCTCGGCCTCGAACACGGCAG	0.652000													4	18					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45765859	45765859	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:45765859G>A	ENST00000357450.4	-	15	2394	c.2395C>T	c.(2395-2397)Cgg>Tgg	p.R799W	SMC1B_ENST00000404354.3_Missense_Mutation_p.R799W	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	799					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TCTTGTTGCCGTTTAACATGT	0.264000													7	158					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32692772	32692772	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:32692772G>A	ENST00000421745.2	+	27	5670	c.5536G>A	c.(5536-5538)Gac>Aac	p.D1846N		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	1846					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					AATTCTTCATGACTTAATACC	0.383000													7	33					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119738445	119738445	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:119738445C>G	ENST00000313400.4	-	9	1799	c.1699G>C	c.(1699-1701)Gag>Cag	p.E567Q	ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.E567Q|ASTN2_ENST00000361209.2_Missense_Mutation_p.E516Q			O75129	ASTN2_HUMAN	astrotactin 2	567						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TAGCCCCTCTCAAGTGTCGTG	0.498000													15	36					0	0	1	0	0
AGO1	26523	broad.mit.edu	37	1	36367847	36367847	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:36367847C>T	ENST00000373204.4	+	11	1519	c.1306C>T	c.(1306-1308)Cgg>Tgg	p.R436W	AGO1_ENST00000373206.1_Missense_Mutation_p.R361W	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		CTGGGACATGCGGGGGAAACA	0.572000													5	234					0	0	1	0	0
HIST1H2AL	8332	broad.mit.edu	37	6	27833210	27833210	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:27833210C>T	ENST00000357320.2	+	1	177	c.78C>T	c.(76-78)ttC>ttT	p.F26F		NM_003511.2	NP_003502.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	26					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|urinary_tract(2)	9						GTCTCCAGTTCCCCGTGGGCC	0.657000													20	126					0	0	1	0	0
OPN1SW	611	broad.mit.edu	37	7	128415508	128415508	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:128415508G>T	ENST00000249389.2	-	1	336	c.337C>A	c.(337-339)Ctg>Atg	p.L113M		NM_001708.2	NP_001699.1	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	113					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|stomach(1)	19						ACAGTGCCCAGGAAGCCCTCC	0.547000													41	107					1.59932e-28	1.75722e-28	1	1	0
AKT1	207	broad.mit.edu	37	14	105239675	105239675	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:105239675G>A	ENST00000554581.1	-	9	2350	c.870C>T	c.(868-870)atC>atT	p.I290I	AKT1_ENST00000407796.2_Silent_p.I290I|AKT1_ENST00000554192.1_Silent_p.I10I|AKT1_ENST00000402615.2_Silent_p.I290I|AKT1_ENST00000349310.3_Silent_p.I290I|AKT1_ENST00000544168.1_Silent_p.I228I|AKT1_ENST00000554585.1_5'UTR|AKT1_ENST00000555528.1_Silent_p.I290I|AKT1_ENST00000554848.1_Silent_p.I290I			P31749	AKT1_HUMAN	v-akt murine thymoma viral oncogene homolog 1	290	Protein kinase.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			NS(3)|breast(97)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(7)|lung(10)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|thyroid(10)|urinary_tract(15)	176		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	CGAAGTCTGTGATCTTAATGT	0.642000		1	Mis		"""breast, colorectal, ovarian, NSCLC"""								4	40					0	0	1	0	0
CYB5B	80777	broad.mit.edu	37	16	69481170	69481170	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr16:69481170G>A	ENST00000512062.1	+	2	451	c.280G>A	c.(280-282)Gat>Aat	p.D94N	CYB5B_ENST00000307892.8_Missense_Mutation_p.D98N|CYB5B_ENST00000561792.1_Missense_Mutation_p.D94N|CYB5B_ENST00000515314.1_Missense_Mutation_p.D94N			O43169	CYB5B_HUMAN	cytochrome b5 type B (outer mitochondrial membrane)	94	Cytochrome b5 heme-binding.				electron transport chain|transport	integral to membrane|mitochondrial outer membrane	heme binding			endometrium(3)|kidney(3)|lung(2)	8		Ovarian(137;0.101)				CTACATTGGTGATATCCATCC	0.438000													10	77					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	64					0	0	1	0	0
ADAM10	102	broad.mit.edu	37	15	58925411	58925411	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr15:58925411T>A	ENST00000260408.3	-	9	1603	c.1160A>T	c.(1159-1161)cAt>cTt	p.H387L	ADAM10_ENST00000561288.1_Intron|ADAM10_ENST00000402627.1_Intron|ADAM10_ENST00000396140.2_Missense_Mutation_p.H86L	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	387	Peptidase M12B.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		TCCAAAGTTATGTCCAACTTC	0.323000													30	21					0	0	1	0	0
SEL1L2	80343	broad.mit.edu	37	20	13850197	13850197	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr20:13850197C>G	ENST00000284951.5	-	14	1281	c.1207G>C	c.(1207-1209)Gaa>Caa	p.E403Q	SEL1L2_ENST00000378072.5_Missense_Mutation_p.E403Q|SEL1L2_ENST00000486903.1_5'UTR			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	403						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						CACCCTTTTTCCGCAGCTTTC	0.388000													9	66					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106843678	106843678	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:106843678C>T	ENST00000276185.4	+	16	2508	c.2508C>T	c.(2506-2508)ctC>ctT	p.L836L				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	836						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						CCCAGCACCTCAACAAGGACA	0.592000													9	59					0	0	1	0	0
TUBB	203068	broad.mit.edu	37	6	30691431	30691431	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:30691431G>C	ENST00000396389.1	+	4	1131	c.538G>C	c.(538-540)Gag>Cag	p.E180Q	TUBB_ENST00000327892.8_Missense_Mutation_p.E198Q|XXbac-BPG252P9.9_ENST00000607476.1_RNA|TUBB_ENST00000396384.1_Missense_Mutation_p.E126Q|TUBB_ENST00000330914.3_Missense_Mutation_p.E126Q|TUBB_ENST00000435534.1_Intron			P07437	TBB5_HUMAN	tubulin, beta class I	198					cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding			breast(1)|endometrium(1)|kidney(8)|large_intestine(3)|lung(1)|ovary(1)|urinary_tract(1)	16					Colchicine(DB01394)|Vinblastine(DB00570)|Vincristine(DB00541)|Vinorelbine(DB00361)	GAATACTGATGAGACCTATTG	0.522000													6	113					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2701773	2701773	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr4:2701773G>A	ENST00000324666.5	+	17	3352	c.3001G>A	c.(3001-3003)Gct>Act	p.A1001T	FAM193A_ENST00000545951.1_Missense_Mutation_p.A1001T|FAM193A_ENST00000505311.1_Missense_Mutation_p.A1001T|FAM193A_ENST00000502458.1_Missense_Mutation_p.A1023T|FAM193A_ENST00000382839.3_Missense_Mutation_p.A1001T	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	1001										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						AGGGCTAGGGGCTGATGGGGA	0.537000													6	120					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179430797	179430797	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:179430797G>T	ENST00000589042.1	-	326	80286	c.80062C>A	c.(80062-80064)Cag>Aag	p.Q26688K	TTN_ENST00000342175.6_Missense_Mutation_p.Q17815K|TTN_ENST00000460472.2_Missense_Mutation_p.Q17623K|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.Q17748K|TTN_ENST00000342992.6_Missense_Mutation_p.Q24120K|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.Q25047K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25047	Fibronectin type-III 94.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCAAATTCTGTGGTGGTCCT	0.423000													8	245					0.00307968	0.0031158	1	1	0
FADS2	9415	broad.mit.edu	37	11	61583770	61583770	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:61583770G>A	ENST00000257261.6	+	1	43	c.13G>A	c.(13-15)Gag>Aag	p.E5K	FADS2_ENST00000574708.1_Intron|FADS1_ENST00000541683.1_Intron|FADS1_ENST00000350997.7_Intron			O95864	FADS2_HUMAN	fatty acid desaturase 2	0					electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			breast(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20					Alpha-Linolenic Acid(DB00132)	GCACGGCAGGGAGGCGGGACC	0.632000													4	67					0	0	1	0	0
TBC1D2B	23102	broad.mit.edu	37	15	78294029	78294029	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr15:78294029C>G	ENST00000409931.3	-	12	2699	c.2628G>C	c.(2626-2628)ttG>ttC	p.L876F	TBC1D2B_ENST00000300584.3_Missense_Mutation_p.L876F			Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B	876						intracellular	protein binding|Rab GTPase activator activity			breast(3)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26						CTTGCAATTTCAAAATCTCCT	0.418000													3	15					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr16:90162513T>C	ENST00000567960.1	+	0	1249				TUBB8P7_ENST00000564451.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													4	169					0	0	1	0	0
ZNF184	7738	broad.mit.edu	37	6	27424610	27424610	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:27424610C>T	ENST00000211936.6	-	5	577	c.293G>A	c.(292-294)tGt>tAt	p.C98Y	ZNF184_ENST00000377419.1_Missense_Mutation_p.C98Y	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	98	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						CTTACCTGCACAGGTACCTAC	0.438000													4	99					0	0	1	0	0
BCL6B	255877	broad.mit.edu	37	17	6928498	6928498	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:6928498G>A	ENST00000293805.5	+	5	960	c.868G>A	c.(868-870)Gaa>Aaa	p.E290K		NM_181844.3	NP_862827.1	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B	290						nucleus	zinc ion binding			skin(1)	1						ATCACCCTCTGAACGGGCTCG	0.567000													13	155					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2411641	2411641	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:2411641G>C	ENST00000449969.1	+	4	615	c.454G>C	c.(454-456)Gac>Cac	p.D152H	PLCH2_ENST00000419816.2_Missense_Mutation_p.D179H|PLCH2_ENST00000378488.3_Missense_Mutation_p.D179H|PLCH2_ENST00000378486.3_Missense_Mutation_p.D179H|PLCH2_ENST00000288766.5_Intron|PLCH2_ENST00000378483.2_Intron			O75038	PLCH2_HUMAN	phospholipase C, eta 2	179	Necessary for plasma membrane localization (By similarity).|PH.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GCAGACGTTTGACGAGGCCGA	0.617000													45	156					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220505519	220505519	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:220505519G>A	ENST00000358055.3	+	22	3968	c.3456G>A	c.(3454-3456)acG>acA	p.T1152T	SLC4A3_ENST00000273063.6_Silent_p.T1179T|SLC4A3_ENST00000317151.3_Silent_p.T1152T|SLC4A3_ENST00000373760.2_Silent_p.T1152T|SLC4A3_ENST00000373762.3_Silent_p.T1179T			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	1152	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGTGAAGACGTGGCGGATGC	0.647000													8	49					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140744753	140744753	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:140744753G>C	ENST00000518069.1	+	1	856	c.856G>C	c.(856-858)Gaa>Caa	p.E286Q	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAATGAAGAAGAAAAAATTTC	0.448000													11	49					0	0	1	0	0
TTK	7272	broad.mit.edu	37	6	80749472	80749472	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:80749472G>A	ENST00000509894.1	+	19	3016	c.2187G>A	c.(2185-2187)ggG>ggA	p.G729G	TTK_ENST00000369798.2_Silent_p.G730G|TTK_ENST00000230510.3_Silent_p.G729G			P33981	TTK_HUMAN	TTK protein kinase	730	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TGACTTACGGGAAAACACCAT	0.313000													5	198					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73474269	73474269	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:73474269G>T	ENST00000252034.7	+	23	1867	c.1468G>T	c.(1468-1470)Ggt>Tgt	p.G490C	ELN_ENST00000380584.4_Missense_Mutation_p.G457C|ELN_ENST00000445912.1_Missense_Mutation_p.G490C|ELN_ENST00000429192.1_Missense_Mutation_p.G476C|ELN_ENST00000380562.4_Missense_Mutation_p.G496C|ELN_ENST00000320399.6_Missense_Mutation_p.G490C|ELN_ENST00000320492.7_Missense_Mutation_p.G409C|ELN_ENST00000358929.4_Missense_Mutation_p.G525C|CTB-51J22.1_ENST00000435932.1_RNA|ELN_ENST00000414324.1_Missense_Mutation_p.G466C|ELN_ENST00000380553.4_Missense_Mutation_p.G354C|ELN_ENST00000380575.4_Missense_Mutation_p.G461C|ELN_ENST00000380576.5_Missense_Mutation_p.G471C|ELN_ENST00000357036.5_Missense_Mutation_p.G495C|ELN_ENST00000458204.1_Missense_Mutation_p.G480C	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	519	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TCCTGGTGTCGGTGTGGCTCC	0.602000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						36	223					2.51541e-25	2.75497e-25	1	1	0
RP11-383M4.6	0	broad.mit.edu	37	9	84562529	84562529	+	RNA	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:84562529G>C	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							ATGATCCGGAGACATCTTCAG	0.483000													8	70					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	105011449	105011449	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:105011449G>C	ENST00000372582.1	+	11	2612	c.1856G>C	c.(1855-1857)aGa>aCa	p.R619T	IL1RAPL2_ENST00000538500.1_Missense_Mutation_p.R224T|IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.R619T	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	619					central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						CACTGTTGCAGAGGTTATAAA	0.483000													25	124					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141202206	141202206	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:141202206C>G	ENST00000389484.3	-	64	11071	c.10100G>C	c.(10099-10101)gGa>gCa	p.G3367A		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3367	LDL-receptor class A 22.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGCACAGAGTCCAGTCCCACA	0.418000										TSP Lung(27;0.18)			8	87					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119738468	119738468	+	Splice_Site	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:119738468C>G	ENST00000313400.4	-	9	1777		c.e9-1		ASTN2_ENST00000361477.3_Splice_Site|ASTN2_ENST00000373996.3_Splice_Site|ASTN2_ENST00000361209.2_Splice_Site			O75129	ASTN2_HUMAN	astrotactin 2							integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GGGCCAAGGTCTATGGGAAGA	0.493000													13	38					0	0	1	0	0
DMTF1	9988	broad.mit.edu	37	7	86817523	86817523	+	Silent	SNP	T	T	C	rs149430074		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:86817523T>C	ENST00000414194.2	+	13	2311	c.519T>C	c.(517-519)caT>caC	p.H173H	DMTF1_ENST00000394703.5_Silent_p.H439H|DMTF1_ENST00000331242.7_Silent_p.H439H|DMTF1_ENST00000432937.2_Silent_p.H351H|DMTF1_ENST00000413276.2_Intron			Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	439	Interaction with CCND2 (By similarity).|Required for DNA-binding (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)	16	Esophageal squamous(14;0.0058)					GTGTGCAGCATGTTCAGATAA	0.423000													50	129					0	0	1	0	0
COMMD1	150684	broad.mit.edu	37	2	62373555	62373555	+	RNA	SNP	T	T	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:62373555T>A	ENST00000425966.2	-	0	143				AC018462.2_ENST00000421323.1_RNA																							gagGAGGATGTCCTTAAGTTC	0.458000													5	17					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38925400	38925400	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:38925400C>G	ENST00000274276.3	+	15	2541	c.2139C>G	c.(2137-2139)ttC>ttG	p.F713L		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	713	Fibronectin type-III 4.				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					ATGAGTTTTTCATCACTCCAT	0.438000													81	124					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151131098	151131098	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:151131098G>A	ENST00000370325.1	-	4	413	c.360C>T	c.(358-360)atC>atT	p.I120I	GABRE_ENST00000393914.3_5'UTR|GABRE_ENST00000370328.3_Silent_p.I120I			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	120					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GGGAGAAGATGATGTCAATGG	0.478000													14	103					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22925804	22925804	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr15:22925804G>A	ENST00000313077.7	+	2	147	c.22G>A	c.(22-24)Gag>Aag	p.E8K	CYFIP1_ENST00000560848.1_Missense_Mutation_p.E8K	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	8					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GGTGACTCTGGAGGACGCGCT	0.642000													7	34					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214826293	214826293	+	Missense_Mutation	SNP	A	A	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:214826293A>T	ENST00000366955.3	+	16	8451	c.8283A>T	c.(8281-8283)aaA>aaT	p.K2761N	CENPF_ENST00000467765.1_3'UTR	NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2857	Sufficient for centromere localization.|Sufficient for self-association.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		ATTCATTGAAAGCTACTACTC	0.338000													31	140					0	0	1	0	0
FNDC4	64838	broad.mit.edu	37	2	27715639	27715639	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:27715639C>A	ENST00000264703.3	-	6	954	c.563G>T	c.(562-564)tGc>tTc	p.C188F		NM_022823.2	NP_073734.1	Q9H6D8	FNDC4_HUMAN	fibronectin type III domain containing 4	188						integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|prostate(1)|skin(1)	9	Acute lymphoblastic leukemia(172;0.155)					ATACTGACGGCAGAACAGCCC	0.502000													6	62					0.00116845	0.00119264	1	1	0
PGR	5241	broad.mit.edu	37	11	100909997	100909997	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:100909997G>A	ENST00000325455.5	-	8	4105	c.2652C>T	c.(2650-2652)gtC>gtT	p.V884V	PGR_ENST00000263463.5_Silent_p.V782V|PGR_ENST00000534013.1_Silent_p.V290V	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	884	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	GAAGTTGTTTGACAAGCTGTT	0.308000													4	73					0	0	1	0	0
TSPAN32	10077	broad.mit.edu	37	11	2339129	2339129	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:2339129G>A	ENST00000182290.4	+	10	1075	c.938G>A	c.(937-939)tGc>tAc	p.C313Y	TSPAN32_ENST00000381121.3_Silent_p.V252V|TSPAN32_ENST00000451520.2_Missense_Mutation_p.C302Y	NM_139022.2	NP_620591.3	Q96QS1	TSN32_HUMAN	tetraspanin 32	313					cell-cell signaling	integral to membrane				breast(1)|central_nervous_system(1)|lung(4)|ovary(1)|skin(1)	8		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		ctcagtgggtgccctgagcgg	0.597000													4	23					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr3:197348739G>C	ENST00000418868.1	-	0	520					NR_003266.2																						TAATTTTCTAGCTGTGAAAGA	0.398000													5	210					0	0	1	0	0
PTGDR	5729	broad.mit.edu	37	14	52734980	52734980	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:52734980G>A	ENST00000306051.2	+	1	550	c.448G>A	c.(448-450)Gca>Aca	p.A150T	PTGDR_ENST00000553372.1_Missense_Mutation_p.A150T	NM_000953.2	NP_000944.1	Q13258	PD2R_HUMAN	prostaglandin D2 receptor (DP)	150						integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	GCGCCTGGGCGCACTGGTGGC	0.647000													15	107					0	0	1	0	0
SLC25A42	284439	broad.mit.edu	37	19	19216416	19216416	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:19216416T>A	ENST00000318596.7	+	5	411	c.260T>A	c.(259-261)cTc>cAc	p.L87H	SLC25A42_ENST00000600275.1_Intron	NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	87					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			GAGGGATTTCTCAGCTTGTGG	0.632000													4	36					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1260953	1260953	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr16:1260953G>A	ENST00000348261.5	+	21	4453	c.4205G>A	c.(4204-4206)cGg>cAg	p.R1402Q	CACNA1H_ENST00000565831.1_Missense_Mutation_p.R1402Q|CACNA1H_ENST00000358590.4_Missense_Mutation_p.R1402Q	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1402					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CGTCTGCTGCGGACCCTGCGG	0.692000													17	183					0	0	1	0	0
FRS3	10817	broad.mit.edu	37	6	41739249	41739249	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:41739249G>A	ENST00000373018.3	-	7	838	c.587C>T	c.(586-588)cCg>cTg	p.P196L	FRS3_ENST00000259748.2_Missense_Mutation_p.P196L	NM_006653.3	NP_006644.1	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	196					fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TTCACTGGCCGGTGTGTTGAC	0.627000													18	122					0	0	1	0	0
BCAS2	10286	broad.mit.edu	37	1	115123922	115123922	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:115123922C>G	ENST00000369541.3	-	2	231	c.184G>C	c.(184-186)Gaa>Caa	p.E62Q	BCAS2_ENST00000485021.1_5'UTR	NM_005872.2	NP_005863.1	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	62					mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			biliary_tract(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)	13	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATACTTACTTCAAAGGCAGAA	0.453000													39	205					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234878921	234878921	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:234878921G>A	ENST00000324695.4	+	17	2246	c.2206G>A	c.(2206-2208)Gtg>Atg	p.V736M	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	736						integral to membrane		p.V736M(1)		breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CTCCCCCTTCGTGGTCTTCTC	0.547000													38	235					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32964777	32964777	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:32964777G>A	ENST00000321639.5	+	10	2809	c.2481G>A	c.(2479-2481)cgG>cgA	p.R827R		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	827						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		TGCGCTACCGGCACAAGCGCA	0.627000													4	122					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	81209453	81209453	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:81209453C>A	ENST00000555265.1	-	19	3147	c.2772G>T	c.(2770-2772)gaG>gaT	p.E924D	CEP128_ENST00000281129.3_Missense_Mutation_p.E924D			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	924						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						CCAGAAGCTGCTCCTGCCTTT	0.403000													16	109					6.49762e-13	7.00525e-13	1	1	0
CCDC102B	79839	broad.mit.edu	37	18	66541979	66541979	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr18:66541979C>G	ENST00000360242.5	+	5	1127	c.1010C>G	c.(1009-1011)tCt>tGt	p.S337C	CCDC102B_ENST00000319445.6_Missense_Mutation_p.S337C|CCDC102B_ENST00000577772.1_3'UTR|CCDC102B_ENST00000584156.1_Missense_Mutation_p.S337C|CCDC102B_ENST00000358653.5_Missense_Mutation_p.S337C	NM_024781.2	NP_079057.2	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	337										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				GAATCCAAATCTCAAAACAGC	0.328000													9	43					0	0	1	0	0
IMMP1L	196294	broad.mit.edu	37	11	31484801	31484801	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:31484801T>C	ENST00000278200.1	-	3	218	c.23A>G	c.(22-24)aAa>aGa	p.K8R	IMMP1L_ENST00000526776.1_Missense_Mutation_p.K8R|IMMP1L_ENST00000533642.1_Intron|IMMP1L_ENST00000532287.1_Missense_Mutation_p.K8R|IMMP1L_ENST00000534812.1_Intron|IMMP1L_ENST00000528161.1_Intron	NM_144981.1	NP_659418.1	Q96LU5	IMP1L_HUMAN	IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)	8					proteolysis	mitochondrial inner membrane	serine-type peptidase activity			breast(1)|cervix(1)|large_intestine(1)|lung(4)	7	Lung SC(675;0.225)					TCGAAAGGTTTTCCCCAGAAC	0.368000													20	56					0	0	1	0	0
NPTX2	4885	broad.mit.edu	37	7	98256572	98256572	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:98256572C>T	ENST00000265634.3	+	4	1149	c.984C>T	c.(982-984)gaC>gaT	p.D328D		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	328	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding	p.D328D(1)		breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			CATTCCAGGACGGAGAGAAGC	0.642000													9	55					0	0	1	0	0
PELP1	27043	broad.mit.edu	37	17	4607333	4607333	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:4607333G>A	ENST00000301396.4	-	1	299	c.74C>T	c.(73-75)tCg>tTg	p.S25L	PELP1_ENST00000436683.2_5'UTR|PELP1_ENST00000269230.7_Missense_Mutation_p.S25L|PELP1_ENST00000574876.1_Missense_Mutation_p.S25L|PELP1_ENST00000570823.1_5'UTR|PELP1_ENST00000572293.1_Missense_Mutation_p.S75L			Q8IZL8	PELP1_HUMAN	proline, glutamate and leucine rich protein 1	25					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	15						GCTCACTGCCGAGAGACCCCC	0.701000													9	55					0	0	1	0	0
DPF3	8110	broad.mit.edu	37	14	73181199	73181199	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:73181199G>A	ENST00000541685.1	-	6	548	c.536C>T	c.(535-537)tCt>tTt	p.S179F	DPF3_ENST00000546183.1_Missense_Mutation_p.S189F|DPF3_ENST00000557704.1_5'UTR|DPF3_ENST00000556509.1_Missense_Mutation_p.S179F	NM_012074.3	NP_036206.3	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	179					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)	22				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GCCCCCTGCAGAGCCGCGAGC	0.597000													5	70					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120322294	120322294	+	Silent	SNP	A	A	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:120322294A>G	ENST00000397843.2	+	22	2083	c.1917A>G	c.(1915-1917)gaA>gaG	p.E639E	ARHGEF12_ENST00000356641.3_Silent_p.E620E|ARHGEF12_ENST00000532993.1_Silent_p.E536E	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	639					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TGAGTCCTGAACCTCAGGACT	0.507000			T	MLL	AML								7	46					0	0	1	0	0
ANAPC2	29882	broad.mit.edu	37	9	140082436	140082436	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:140082436C>T	ENST00000323927.2	-	2	241	c.237G>A	c.(235-237)ctG>ctA	p.L79L		NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	79					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		GATCGTTCTGCAGCACCTCCA	0.612000													10	47					0	0	1	0	0
CRYGD	1421	broad.mit.edu	37	2	208986503	208986503	+	Missense_Mutation	SNP	C	C	T	rs144372987		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:208986503C>T	ENST00000264376.4	-	3	446	c.419G>A	c.(418-420)cGa>cAa	p.R140Q		NM_006891.3	NP_008822.2	P07320	CRGD_HUMAN	crystallin, gamma D	140	Beta/gamma crystallin 'Greek key' 4.				cellular response to reactive oxygen species|visual perception	soluble fraction	protein binding|structural constituent of eye lens			breast(1)|endometrium(1)|lung(3)	5				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		CTGCCGTCCTCGGTAGTTGGA	0.587000													18	111					0	0	1	0	0
ATP1A1	476	broad.mit.edu	37	1	116943599	116943599	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:116943599G>A	ENST00000537345.1	+	19	3052	c.2689G>A	c.(2689-2691)Gat>Aat	p.D897N	ATP1A1_ENST00000369496.4_Missense_Mutation_p.D866N|ATP1A1_ENST00000295598.5_Missense_Mutation_p.D897N	NM_001160233.1	NP_001153705.1	P05023	AT1A1_HUMAN	ATPase, Na+/K+ transporting, alpha 1 polypeptide	897					ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			NS(2)|breast(2)|cervix(3)|endometrium(2)|kidney(5)|large_intestine(9)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	CTGGATCAACGATGTGGAAGA	0.572000													9	50					0	0	1	0	0
VANGL2	57216	broad.mit.edu	37	1	160394931	160394931	+	Silent	SNP	G	G	A	rs146767141		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:160394931G>A	ENST00000368061.2	+	8	1803	c.1329G>A	c.(1327-1329)gcG>gcA	p.A443A		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	443					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane		p.A443A(1)		biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GATACTTGGCGGCTGGACCTA	0.557000													28	36					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56954774	56954774	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:56954774C>G	ENST00000497933.1	+	2	993	c.846C>G	c.(844-846)ttC>ttG	p.F282L		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	252						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						CCCCGCTCTTCTCACTCACTG	0.587000													19	174					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110530664	110530664	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr8:110530664G>A	ENST00000378402.5	+	73	12062	c.11958G>A	c.(11956-11958)aaG>aaA	p.K3986K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3986					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGAGGAGGAAGAGATCCATGG	0.398000										HNSCC(38;0.096)			17	77					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149447	34149447	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:34149447G>T	ENST00000346193.3	-	1	1000	c.949C>A	c.(949-951)Cct>Act	p.P317T		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	317										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						GTCTTGGGAGGCTCCTGGCGG	0.597000													7	35					0.00198382	0.00201893	1	1	0
SMU1	55234	broad.mit.edu	37	9	33056956	33056956	+	Nonsense_Mutation	SNP	T	T	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:33056956T>A	ENST00000397149.3	-	8	924	c.874A>T	c.(874-876)Aag>Tag	p.K292*	SMU1_ENST00000536631.1_Nonsense_Mutation_p.K131*	NM_018225.2	NP_060695.2	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	292						cytoplasm|nucleus				endometrium(2)|lung(4)|ovary(2)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		CTCTGAATCTTCCACACCTTT	0.383000													82	165					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000389561.2_Silent_p.Q2725Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													4	66					0	0	1	0	0
KBTBD2	25948	broad.mit.edu	37	7	32909721	32909721	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:32909721G>A	ENST00000304056.4	-	4	1807	c.1108C>T	c.(1108-1110)Cgc>Tgc	p.R370C	AVL9_ENST00000404479.1_Intron	NM_015483.2	NP_056298.2	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	370										endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|urinary_tract(1)	17			GBM - Glioblastoma multiforme(11;0.0499)			GGCTTTATGCGGACAAAAAGC	0.423000													16	165					0	0	1	0	0
LCP1	3936	broad.mit.edu	37	13	46701814	46701814	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr13:46701814G>A	ENST00000398576.2	-	19	2184	c.1796C>T	c.(1795-1797)gCc>gTc	p.A599V	LCP1_ENST00000323076.2_Missense_Mutation_p.A599V|LCP1_ENST00000435666.2_Missense_Mutation_p.A168V			P13796	PLSL_HUMAN	lymphocyte cytosolic protein 1 (L-plastin)	599	Actin-binding 2.|CH 4.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			breast(2)|kidney(1)|large_intestine(6)|lung(18)|ovary(4)|prostate(2)|skin(1)	34		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TTCTGGCAGGGCATACACTCT	0.488000			T	BCL6	NHL								5	227					0	0	1	0	0
PTGES3L-AARSD1	100885850	broad.mit.edu	37	17	41131263	41131263	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:41131263G>A	ENST00000421990.2	-	4	686	c.341C>T	c.(340-342)tCc>tTc	p.S114F	PTGES3L_ENST00000409446.3_Missense_Mutation_p.S76F|PTGES3L-AARSD1_ENST00000409103.1_Missense_Mutation_p.S53F|PTGES3L-AARSD1_ENST00000360221.4_Missense_Mutation_p.S53F|PTGES3L-AARSD1_ENST00000409399.1_Missense_Mutation_p.S114F|PTGES3L_ENST00000453594.1_Intron	NM_001136042.2	NP_001129514.2																					AATAGAGCGGGAAGAGCGCTT	0.522000													37	198					0	0	1	0	0
ZNF687	57592	broad.mit.edu	37	1	151259741	151259741	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:151259741C>A	ENST00000368879.2	+	2	1072	c.974C>A	c.(973-975)tCt>tAt	p.S325Y		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	325	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCCAGCTCCTCTAGGCCTCTT	0.577000													8	51					0.00307968	0.0031158	1	1	0
LRRK2	120892	broad.mit.edu	37	12	40758833	40758833	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:40758833C>T	ENST00000298910.7	+	49	7429	c.7371C>T	c.(7369-7371)gtC>gtT	p.V2457V		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2457					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CGGTCAGAGTCATGATGACAG	0.348000													18	78					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120009411	120009411	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:120009411G>A	ENST00000371311.3	-	1	368	c.114C>T	c.(112-114)tcC>tcT	p.S38S		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	38										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						TGTCGGGGCCGGAGTCGCCGC	0.741000													17	85					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72850832	72850832	+	Splice_Site	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:72850832C>T	ENST00000293190.5	-	2	546		c.e2+1		GRIN2C_ENST00000578159.1_Intron|GRIN2C_ENST00000347612.4_Splice_Site	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C						glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	TGGACATGCACCTTGGGGGTG	0.622000													4	45					0	0	1	0	0
SLC10A5	347051	broad.mit.edu	37	8	82606635	82606635	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr8:82606635G>A	ENST00000518568.1	-	1	1774	c.573C>T	c.(571-573)tgC>tgT	p.C191C		NM_001010893.2	NP_001010893.1	Q5PT55	NTCP5_HUMAN	solute carrier family 10, member 5	191						integral to membrane	bile acid:sodium symporter activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)	15						AAAGAAACCCGCAAAATGGCA	0.463000													4	125					0	0	1	0	0
PLXDC2	84898	broad.mit.edu	37	10	20506361	20506361	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr10:20506361G>C	ENST00000377252.3	+	11	1970	c.1129G>C	c.(1129-1131)Gag>Cag	p.E377Q	PLXDC2_ENST00000377242.3_Missense_Mutation_p.E328Q|PLXDC2_ENST00000377238.2_3'UTR	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	377						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						CTAGTCAAAAGAGAAGATGTG	0.418000													8	45					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139825539	139825539	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:139825539C>G	ENST00000297183.6	+	6	1250	c.1126C>G	c.(1126-1128)Cta>Gta	p.L376V	ANKHD1_ENST00000394722.3_Missense_Mutation_p.L365V|ANKHD1_ENST00000360839.2_Missense_Mutation_p.L376V|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.L376V|ANKHD1_ENST00000394723.3_Missense_Mutation_p.L376V	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAAGTGCTCTAACACTTGC	0.348000													7	51					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220349284	220349284	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:220349284G>A	ENST00000312358.7	+	30	7231	c.7099G>A	c.(7099-7101)Gag>Aag	p.E2367K	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2367	Arg-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCGTGGGGCCGAGGAGGAGGA	0.731000													5	27					0	0	1	0	0
FAM118A	55007	broad.mit.edu	37	22	45732284	45732284	+	Nonsense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:45732284C>G	ENST00000216214.3	+	9	1880	c.1046C>G	c.(1045-1047)tCa>tGa	p.S349*	FAM118A_ENST00000405548.3_Nonsense_Mutation_p.S167*|FAM118A_ENST00000441876.2_Nonsense_Mutation_p.S349*	NM_001104595.1	NP_001098065.1	Q9NWS6	F118A_HUMAN	family with sequence similarity 118, member A	349						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	11		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CGCACACAATCAGATACTGGT	0.448000													5	61					0	0	1	0	0
SOCS5	9655	broad.mit.edu	37	2	46986576	46986576	+	Missense_Mutation	SNP	T	T	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:46986576T>G	ENST00000306503.5	+	2	1079	c.907T>G	c.(907-909)Tta>Gta	p.L303V	SOCS5_ENST00000394861.2_Missense_Mutation_p.L303V	NM_014011.4	NP_054730.1	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	303					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(9)|ovary(2)	22		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			GGGACCAAAATTAGCTCCTGG	0.433000													45	51					0	0	1	0	0
ZNF639	51193	broad.mit.edu	37	3	179051945	179051945	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr3:179051945C>G	ENST00000326361.3	+	7	1638	c.1193C>G	c.(1192-1194)aCa>aGa	p.T398R	ZNF639_ENST00000484866.1_Missense_Mutation_p.T398R|ZNF639_ENST00000496856.1_Missense_Mutation_p.T398R	NM_016331.1	NP_057415.1	Q9UID6	ZN639_HUMAN	zinc finger protein 639	398	Interaction with CTNNA2.				initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(10)|urinary_tract(1)	16	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			ATTGAACATACAAAAATTTTT	0.323000													33	181					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35965663	35965663	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:35965663T>C	ENST00000274278.3	-	4	1025	c.668A>G	c.(667-669)aAc>aGc	p.N223S	UGT3A1_ENST00000503189.1_Missense_Mutation_p.N223S|UGT3A1_ENST00000513233.1_Intron|UGT3A1_ENST00000507113.1_Missense_Mutation_p.N189S|UGT3A1_ENST00000333811.4_Missense_Mutation_p.N169S	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	223						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTTGATGGTGTTGTCAAATGT	0.438000													49	89					0	0	1	0	0
ATP2C1	27032	broad.mit.edu	37	3	130699488	130699488	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr3:130699488A>G	ENST00000510168.1	+	20	2354	c.1804A>G	c.(1804-1806)Atg>Gtg	p.M602V	ATP2C1_ENST00000359644.3_Missense_Mutation_p.M602V|ATP2C1_ENST00000328560.8_Missense_Mutation_p.M602V|ATP2C1_ENST00000428331.2_Missense_Mutation_p.M602V|ATP2C1_ENST00000513801.1_Missense_Mutation_p.M586V|ATP2C1_ENST00000508532.1_Missense_Mutation_p.M602V|ATP2C1_ENST00000505330.1_Missense_Mutation_p.M586V|ATP2C1_ENST00000393221.4_Missense_Mutation_p.M636V|ATP2C1_ENST00000422190.2_Missense_Mutation_p.M602V|ATP2C1_ENST00000504948.1_Missense_Mutation_p.M586V|ATP2C1_ENST00000507488.2_Missense_Mutation_p.M586V|ATP2C1_ENST00000504381.1_Missense_Mutation_p.M547V|ATP2C1_ENST00000533801.2_Missense_Mutation_p.M597V			P98194	AT2C1_HUMAN	ATPase, Ca++ transporting, type 2C, member 1	602					actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|prostate(2)|skin(2)|urinary_tract(1)	39					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	AATAGATGCAATGGATGTTCA	0.383000									Hailey-Hailey disease				63	57					0	0	1	0	0
UBTF	7343	broad.mit.edu	37	17	42288700	42288700	+	Splice_Site	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:42288700C>G	ENST00000302904.4	-	11	1540		c.e11-1		UBTF_ENST00000343638.5_Splice_Site|UBTF_ENST00000526094.1_Splice_Site|UBTF_ENST00000436088.1_Splice_Site|UBTF_ENST00000393606.3_Splice_Site|CTB-175E5.7_ENST00000586560.1_RNA|UBTF_ENST00000533177.1_Splice_Site|UBTF_ENST00000527034.1_Splice_Site|UBTF_ENST00000529383.1_Splice_Site			P17480	UBF1_HUMAN	upstream binding transcription factor, RNA polymerase I						positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(10)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CTTTCTTTTTCTGGGAAAGTG	0.582000													9	42					0	0	1	0	0
NUAK1	9891	broad.mit.edu	37	12	106461045	106461045	+	Silent	SNP	C	C	T	rs138538652	byFrequency	TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:106461045C>T	ENST00000261402.2	-	7	2900	c.1521G>A	c.(1519-1521)ccG>ccA	p.P507P		NM_014840.2	NP_055655.1	O60285	NUAK1_HUMAN	NUAK family, SNF1-like kinase, 1	507							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.P507P(4)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37						TGGCTGGGTCCGGGGGGCTGG	0.602000													14	53					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414280	20414280	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:20414280G>A	ENST00000380338.4	-	5	850	c.564C>T	c.(562-564)agC>agT	p.S188S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S185S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	188	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S188S(1)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TGGTActactgctgctgctgc	0.502000			T	MLL	ALL								6	285					0	0	1	0	0
SLFN5	162394	broad.mit.edu	37	17	33591649	33591649	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:33591649T>C	ENST00000299977.4	+	4	1734	c.1586T>C	c.(1585-1587)cTg>cCg	p.L529P	SLFN5_ENST00000542451.1_Intron	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	529					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		ATGGAAGCCCTGTTACAGTCC	0.428000													87	61					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47330188	47330188	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:47330188G>C	ENST00000342922.4	+	23	4049	c.3692G>C	c.(3691-3693)gGc>gCc	p.G1231A	MADD_ENST00000349238.3_Missense_Mutation_p.G1251A|MADD_ENST00000311027.5_Missense_Mutation_p.G1269A|MADD_ENST00000406482.1_Missense_Mutation_p.G1188A|MADD_ENST00000405573.2_Missense_Mutation_p.G79A|MADD_ENST00000407859.3_Missense_Mutation_p.G1208A|MADD_ENST00000402799.1_Missense_Mutation_p.G1188A|MADD_ENST00000402192.2_Missense_Mutation_p.G1230A|MADD_ENST00000395336.3_Missense_Mutation_p.G1269A|MADD_ENST00000395344.3_Missense_Mutation_p.G1184A	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	1269	Ser-rich.				activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		AAGCTGGCAGGCAGCCCCATT	0.507000													9	63					0	0	1	0	0
JAK3	3718	broad.mit.edu	37	19	17951090	17951090	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:17951090G>A	ENST00000458235.1	-	9	1302	c.1203C>T	c.(1201-1203)ctC>ctT	p.L401L	JAK3_ENST00000534444.1_Silent_p.L401L|JAK3_ENST00000526008.1_5'UTR|JAK3_ENST00000527670.1_Silent_p.L401L	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	401	SH2; atypical.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						GGCTGCGGCGGAGAACATAGG	0.597000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								4	40					0	0	1	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61299837	61299837	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr20:61299837G>A	ENST00000217159.1	+	10	2025	c.1820G>A	c.(1819-1821)cGt>cAt	p.R607H	SLCO4A1_ENST00000470412.1_3'UTR|SLCO4A1_ENST00000370507.1_Missense_Mutation_p.R607H	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	607					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			AGATGTGTCCGTGACCCTCAG	0.547000											OREG0026115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	165					0	0	1	0	0
C7orf62	219557	broad.mit.edu	37	7	88424155	88424155	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:88424155T>A	ENST00000297203.2	-	2	287	c.102A>T	c.(100-102)caA>caT	p.Q34H	ZNF804B_ENST00000333190.4_Intron	NM_152706.3	NP_689919.1	Q8TBZ9	CG062_HUMAN	chromosome 7 open reading frame 62	34										NS(1)|breast(1)|endometrium(3)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	30						GTTTCTCTTCTTGAAAGTGCA	0.423000													44	104					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56822387	56822387	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:56822387C>T	ENST00000229201.4	-	12	1505	c.1351G>A	c.(1351-1353)Gag>Aag	p.E451K	TIMELESS_ENST00000554616.1_Intron|TIMELESS_ENST00000553532.1_Missense_Mutation_p.E452K	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	452					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						ATGTCCATCTCATTCACTGTT	0.572000													6	42					0	0	1	0	0
ZNF687	57592	broad.mit.edu	37	1	151260445	151260445	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:151260445G>A	ENST00000368879.2	+	2	1776	c.1678G>A	c.(1678-1680)Gag>Aag	p.E560K		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CATGCGCATCGAGGTCACCTG	0.627000													14	85					0	0	1	0	0
IGLV5-52	28779	broad.mit.edu	37	22	22673314	22673314	+	RNA	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:22673314C>T	ENST00000390289.2	+	0	112				LL22NC03-80A10.6_ENST00000426066.1_RNA																							TCTGGAGCATCAGTCAGACTC	0.537000													33	296					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158637691	158637691	+	Silent	SNP	A	A	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:158637691A>T	ENST00000368148.3	-	15	2175	c.1995T>A	c.(1993-1995)gtT>gtA	p.V665V	SPTA1_ENST00000368147.3_Silent_p.V665V	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	665					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AGAGGCTGGCAACTTCACTCA	0.438000													32	73					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23868231	23868231	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:23868231A>G	ENST00000405093.3	-	15	1667	c.1597T>C	c.(1597-1599)Tcc>Ccc	p.S533P	MYH6_ENST00000356287.3_Missense_Mutation_p.S533P	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	533	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TCCAGGATGGACATGATGCCC	0.542000													11	83					0	0	1	0	0
SMAD4	4089	broad.mit.edu	37	18	48575095	48575095	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr18:48575095C>T	ENST00000342988.3	+	3	827	c.289C>T	c.(289-291)Cgt>Tgt	p.R97C	SMAD4_ENST00000452201.2_Missense_Mutation_p.R97C|SMAD4_ENST00000398417.2_Missense_Mutation_p.R97C|SMAD4_ENST00000588745.1_Missense_Mutation_p.R97C|RP11-729L2.2_ENST00000590722.2_3'UTR	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	97	MH1.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(36)|p.?(4)		NS(2)|biliary_tract(19)|breast(9)|central_nervous_system(2)|endometrium(2)|gastrointestinal_tract_(site_indeterminate)(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(142)|liver(2)|lung(27)|oesophagus(4)|ovary(7)|pancreas(180)|prostate(3)|skin(1)|small_intestine(9)|stomach(5)|testis(2)|thyroid(19)|upper_aerodigestive_tract(10)|urinary_tract(2)|vulva(1)	454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GATCTATGCCCGTCTCTGGAG	0.373000													13	30					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123516636	123516636	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:123516636C>G	ENST00000422452.2	-	31	7387	c.7324G>C	c.(7324-7326)Ggt>Cgt	p.G2442R	STAG2_ENST00000469481.1_Intron|TENM1_ENST00000371130.3_Missense_Mutation_p.G2435R	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		AATTGGAAACCAAATAGCTCC	0.323000													40	230					0	0	1	0	0
LRCH4	4034	broad.mit.edu	37	7	100175784	100175784	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:100175784C>T	ENST00000310300.6	-	7	998	c.946G>A	c.(946-948)Gag>Aag	p.E316K	LRCH4_ENST00000497245.1_5'UTR	NM_002319.3	NP_002310.2	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 4	316					nervous system development	PML body	protein binding			NS(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	23	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCCTTACCTCATTTCCAGAC	0.587000													6	28					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21581470	21581470	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:21581470G>C	ENST00000425654.2	+	12	1898	c.1418G>C	c.(1417-1419)aGt>aCt	p.S473T	CNKSR2_ENST00000379510.3_Missense_Mutation_p.S503T|CNKSR2_ENST00000279451.4_Missense_Mutation_p.S503T|CNKSR2_ENST00000485012.1_3'UTR|CNKSR2_ENST00000543067.1_Missense_Mutation_p.S454T	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	503	DUF1170.				regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						GGTGATAAGAGTAATAGCCCA	0.408000													13	78					0	0	1	0	0
B4GALT4	8702	broad.mit.edu	37	3	118948733	118948733	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr3:118948733C>T	ENST00000467604.1	-	3	605	c.214G>A	c.(214-216)Gta>Ata	p.V72I	B4GALT4-AS1_ENST00000470790.1_RNA|B4GALT4_ENST00000471675.1_Missense_Mutation_p.V25I|B4GALT4_ENST00000460321.1_Intron|B4GALT4_ENST00000483209.1_Missense_Mutation_p.V72I|B4GALT4_ENST00000393765.2_Missense_Mutation_p.V72I|B4GALT4_ENST00000359213.3_Missense_Mutation_p.V72I			O60513	B4GT4_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4	72					membrane lipid metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding|N-acetyllactosamine synthase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(6)|skin(2)|stomach(2)	14				GBM - Glioblastoma multiforme(114;0.222)	N-Acetyl-D-glucosamine(DB00141)	TCAAGTTCTACCTTCTTCGTG	0.368000													7	104					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87969626	87969626	+	Silent	SNP	A	A	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:87969626A>G	ENST00000369577.3	+	8	6322	c.6279A>G	c.(6277-6279)aaA>aaG	p.K2093K	ZNF292_ENST00000339907.4_Silent_p.K2088K	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	2093					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		AGGAGAAAAAACGAAAGAAGC	0.403000													52	32					0	0	1	0	0
SPECC1	92521	broad.mit.edu	37	17	20109066	20109066	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:20109066C>T	ENST00000395530.2	+	2	1669	c.1461C>T	c.(1459-1461)gcC>gcT	p.A487A	SPECC1_ENST00000395522.2_Silent_p.A487A|SPECC1_ENST00000472876.1_Intron|AC004702.2_ENST00000580225.1_lincRNA|SPECC1_ENST00000261503.5_Silent_p.A568A|SPECC1_ENST00000395529.3_Silent_p.A568A|SPECC1_ENST00000395525.3_Silent_p.A487A|SPECC1_ENST00000395527.4_Silent_p.A568A|SPECC1_ENST00000536879.1_Intron	NM_001033555.2	NP_001028727.1	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	568						nucleus		p.A568A(1)		breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		CCACAGAGGCCAGTGCTGTGG	0.468000													15	78					0	0	1	0	0
GMPR2	51292	broad.mit.edu	37	14	24707474	24707474	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:24707474G>A	ENST00000557854.1	+	8	1051	c.774G>A	c.(772-774)atG>atA	p.M258I	GMPR2_ENST00000559910.1_Missense_Mutation_p.M207I|GMPR2_ENST00000559836.1_Missense_Mutation_p.M240I|GMPR2_ENST00000348719.7_Missense_Mutation_p.M240I|GMPR2_ENST00000559104.1_Missense_Mutation_p.M225I|GMPR2_ENST00000355299.4_Missense_Mutation_p.M240I|GMPR2_ENST00000420554.2_Missense_Mutation_p.M258I|GMPR2_ENST00000456667.3_Missense_Mutation_p.M212I|GMPR2_ENST00000399440.2_Missense_Mutation_p.M240I			Q9P2T1	GMPR2_HUMAN	guanosine monophosphate reductase 2	240					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage	cytosol	GMP reductase activity|metal ion binding			large_intestine(4)|lung(3)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(265;0.0181)		ACTTCGTGATGCTGGGTGGCA	0.542000													10	53					0	0	1	0	0
SNTB1	6641	broad.mit.edu	37	8	121823612	121823612	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr8:121823612C>T	ENST00000395601.3	-	2	886	c.472G>A	c.(472-474)Gac>Aac	p.D158N	SNTB1_ENST00000517992.1_Missense_Mutation_p.D158N|SNTB1_ENST00000519177.1_5'UTR	NM_021021.3	NP_066301.1	Q13884	SNTB1_HUMAN	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	158	PDZ.|PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(6)	24	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			AGGATGGCGTCGCCCACGTAC	0.647000													33	94					0	0	1	0	0
SHOX	6473	broad.mit.edu	37	X	601763	601763	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:601763G>A	ENST00000381578.1	+	5	1265	c.574G>A	c.(574-576)Gac>Aac	p.D192N	SHOX_ENST00000554971.1_Missense_Mutation_p.D192N|SHOX_ENST00000334060.3_Missense_Mutation_p.D192N|SHOX_ENST00000381575.1_Missense_Mutation_p.D192N	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	192					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CAACCACCTAGACGCCTGCCG	0.582000													4	80					0	0	1	0	0
METTL18	92342	broad.mit.edu	37	1	169762501	169762501	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:169762501C>T	ENST00000310392.4	-	2	689	c.336G>A	c.(334-336)atG>atA	p.M112I	C1orf112_ENST00000498289.1_Intron|METTL18_ENST00000303469.2_Missense_Mutation_p.M112I	NM_033418.2	NP_219486.1	O95568	MET18_HUMAN	methyltransferase like 18	112						cytoplasm	protein methyltransferase activity			kidney(1)|large_intestine(3)|lung(4)	8						TATTTTCTAACATCTTCTTTA	0.408000													8	89					0	0	1	0	0
SEMA4D	10507	broad.mit.edu	37	9	92003563	92003563	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:92003563C>T	ENST00000450295.1	-	11	1871	c.1095G>A	c.(1093-1095)ccG>ccA	p.P365P	SEMA4D_ENST00000438547.2_Silent_p.P365P|SEMA4D_ENST00000356444.2_Silent_p.P365P|SEMA4D_ENST00000420987.1_Silent_p.P365P|SEMA4D_ENST00000339861.4_Silent_p.P365P|SEMA4D_ENST00000422704.2_Silent_p.P365P|SEMA4D_ENST00000455551.2_Silent_p.P365P|SEMA4D_ENST00000343780.4_Silent_p.P365P			Q92854	SEM4D_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	365	Sema.				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(8)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34						CTCCAGGCCGCGGCTTGGGTA	0.652000													28	9					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57432763	57432763	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:57432763C>T	ENST00000442789.2	-	17	1650	c.1363G>A	c.(1363-1365)Gag>Aag	p.E455K	MYO1A_ENST00000300119.3_Missense_Mutation_p.E455K|MYO1A_ENST00000476795.1_5'UTR|MYO1A_ENST00000544473.1_Missense_Mutation_p.E293K	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	455	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						AGGCACTCCTCATCCAACATG	0.557000													9	30					0	0	1	0	0
POLR1B	84172	broad.mit.edu	37	2	113322052	113322052	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:113322052C>T	ENST00000263331.5	+	10	2302	c.1722C>T	c.(1720-1722)atC>atT	p.I574I	POLR1B_ENST00000409894.3_Intron|POLR1B_ENST00000537335.1_Silent_p.I363I|POLR1B_ENST00000541869.1_Silent_p.I612I|POLR1B_ENST00000417433.2_Silent_p.I518I	NM_019014.4	NP_061887.2	Q9H9Y6	RPA2_HUMAN	polymerase (RNA) I polypeptide B, 128kDa	574					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(3)|endometrium(9)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42						CTCCAGGCATCGCAGATTCTC	0.493000													27	151					0	0	1	0	0
OPA1	4976	broad.mit.edu	37	3	193361784	193361784	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr3:193361784C>T	ENST00000361510.2	+	16	1732	c.1498C>T	c.(1498-1500)Cgc>Tgc	p.R500C	OPA1_ENST00000361908.3_Missense_Mutation_p.R482C|OPA1_ENST00000392438.3_Missense_Mutation_p.R445C|OPA1_ENST00000361828.2_Missense_Mutation_p.R463C|OPA1_ENST00000361150.2_Missense_Mutation_p.R446C|OPA1_ENST00000361715.2_Missense_Mutation_p.R464C	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)	445					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		GGATGCTGAACGCAGTATTGT	0.373000													13	124					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101362340	101362340	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:101362340C>T	ENST00000344327.3	-	3	1499	c.1075G>A	c.(1075-1077)Ggt>Agt	p.G359S	TRPC6_ENST00000532133.1_Missense_Mutation_p.G359S|TRPC6_ENST00000360497.4_Missense_Mutation_p.G359S|TRPC6_ENST00000348423.4_Intron	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	359					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TTTGGGCGACCGTGATCACCA	0.433000													32	274					0	0	1	0	0
EXOSC3	51010	broad.mit.edu	37	9	37785032	37785032	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:37785032G>C	ENST00000327304.5	-	1	22	c.10C>G	c.(10-12)Cct>Gct	p.P4A	RP11-613M10.9_ENST00000540557.1_Intron|EXOSC3_ENST00000396521.3_Missense_Mutation_p.P4A	NM_016042.3	NP_057126.2	Q9NQT5	EXOS3_HUMAN	exosome component 3	4					CUT catabolic process|DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|isotype switching|rRNA processing	cytoplasmic exosome (RNase complex)|cytosol|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|protein binding|RNA binding			breast(2)|endometrium(1)|kidney(1)	4				GBM - Glioblastoma multiforme(29;0.00771)|Lung(182;0.221)		ACAGACGCAGGTTCGGCCATC	0.667000													7	26					0	0	1	0	0
MVD	4597	broad.mit.edu	37	16	88722565	88722565	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr16:88722565C>T	ENST00000301012.3	-	5	580	c.551G>A	c.(550-552)cGg>cAg	p.R184Q	MVD_ENST00000568709.1_5'UTR	NM_002461.1	NP_002452.1	P53602	MVD1_HUMAN	mevalonate (diphospho) decarboxylase	184					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity			endometrium(3)|large_intestine(1)|lung(7)|ovary(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.0478)		GGCCACTTGCCGAGCGATGCT	0.692000													16	94					0	0	1	0	0
TTC25	83538	broad.mit.edu	37	17	40094848	40094848	+	RNA	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:40094848G>A	ENST00000591658.1	+	0	732							Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25							cytoplasm	protein binding			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				CCTGACTGTGGAGGACCTCAT	0.587000													10	186					0	0	1	0	0
MEX3A	92312	broad.mit.edu	37	1	156046533	156046533	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:156046533G>A	ENST00000532414.2	-	2	1394	c.1395C>T	c.(1393-1395)ggC>ggT	p.G465G		NM_001093725.1	NP_001087194.1	A1L020	MEX3A_HUMAN	mex-3 RNA binding family member A	465						cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	Hepatocellular(266;0.158)|all_neural(408;0.195)					AATCCCGCCCGCCGCCGGGGC	0.692000													4	18					0	0	1	0	0
VSTM1	284415	broad.mit.edu	37	19	54544280	54544280	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:54544280C>G	ENST00000338372.2	-	9	821	c.646G>C	c.(646-648)Gag>Cag	p.E216Q	VSTM1_ENST00000425006.2_3'UTR|VSTM1_ENST00000366170.2_Missense_Mutation_p.E128Q|VSTM1_ENST00000376626.1_Missense_Mutation_p.E185Q	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	216						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		GAAGCTGCCTCAGACAGGGCG	0.527000													5	37					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116525882	116525882	+	Missense_Mutation	SNP	C	C	T	rs142535149		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:116525882C>T	ENST00000410059.1	+	13	1603	c.1123C>T	c.(1123-1125)Ccc>Tcc	p.P375S	DPP10_ENST00000310323.8_Missense_Mutation_p.P368S|DPP10_ENST00000409163.1_Missense_Mutation_p.P325S|DPP10_ENST00000393147.2_Missense_Mutation_p.P379S	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	375					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						GAATGAGGAGCCCGTGTTTTC	0.448000													11	64					0	0	1	0	0
TBC1D22B	55633	broad.mit.edu	37	6	37250011	37250011	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:37250011C>T	ENST00000373491.3	+	4	618	c.472C>T	c.(472-474)Cgg>Tgg	p.R158W		NM_017772.2	NP_060242.2	Q9NU19	TB22B_HUMAN	TBC1 domain family, member 22B	158						intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|prostate(1)	15			OV - Ovarian serous cystadenocarcinoma(102;0.241)			ACTCCCTCTCCGGCCCATCAT	0.537000													13	61					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117143419	117143419	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:117143419G>A	ENST00000307564.4	-	2	356	c.195C>T	c.(193-195)caC>caT	p.H65H	AKNA_ENST00000312033.3_Silent_p.H65H|AKNA_ENST00000374088.3_Silent_p.H65H	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	65					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						GGGGCGGCAGGTGCTGCTGGG	0.607000													5	49					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48387816	48387816	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:48387816G>C	ENST00000380518.3	-	13	995	c.831C>G	c.(829-831)ttC>ttG	p.F277L	COL2A1_ENST00000337299.6_Missense_Mutation_p.F208L	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	277	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GGGTTCCTGGGAAACCACGAG	0.542000													46	224					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57309018	57309018	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:57309018G>A	ENST00000457912.1	+	1	40	c.40G>A	c.(40-42)Gag>Aag	p.E14K				E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	120										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						TTGCTCAGCAGAGGCCAGGGA	0.512000													19	148					0	0	1	0	0
CRYBA4	1413	broad.mit.edu	37	22	27024266	27024266	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:27024266G>A	ENST00000354760.3	+	5	350	c.315G>A	c.(313-315)tcG>tcA	p.S105S	CRYBA4_ENST00000466315.1_3'UTR	NM_001886.2	NP_001877.1	P53673	CRBA4_HUMAN	crystallin, beta A4	105	Beta/gamma crystallin 'Greek key' 3.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens			large_intestine(6)|liver(1)|lung(6)|skin(3)|urinary_tract(2)	18						ACCGTGACTCGAGGCTGACAA	0.567000													14	104					0	0	1	0	0
MMGT1	93380	broad.mit.edu	37	X	135047200	135047200	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:135047200C>T	ENST00000305963.2	-	4	766	c.379G>A	c.(379-381)Gaa>Aaa	p.E127K	MMGT1_ENST00000433339.2_Missense_Mutation_p.E192K	NM_173470.1	NP_775741.1	Q8N4V1	MMGT1_HUMAN	membrane magnesium transporter 1	127						early endosome membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	magnesium ion transmembrane transporter activity			cervix(1)|endometrium(1)|kidney(1)	3						CGCAGTGATTCGAGTTTTCGT	0.413000													31	256					0	0	1	0	0
TKTL1	8277	broad.mit.edu	37	X	153555958	153555958	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:153555958G>T	ENST00000369915.3	+	11	1612	c.1423G>T	c.(1423-1425)Gac>Tac	p.D475Y	TKTL1_ENST00000482044.1_3'UTR|TKTL1_ENST00000217905.7_Missense_Mutation_p.D215Y|TKTL1_ENST00000369912.2_Missense_Mutation_p.D419Y	NM_001145933.1|NM_012253.3	NP_001139405.1|NP_036385.3	P51854	TKTL1_HUMAN	transketolase-like 1	475					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			NS(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(5)|prostate(1)|skin(1)|urinary_tract(2)	34	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGTGTCAGTGACAAGGTCAC	0.468000													21	131					1.50039e-11	1.60756e-11	1	1	0
VPS13D	55187	broad.mit.edu	37	1	12418524	12418524	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:12418524G>A	ENST00000358136.3	+	50	10138	c.10008G>A	c.(10006-10008)atG>atA	p.M3336I	VPS13D_ENST00000356315.4_Missense_Mutation_p.M3311I	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3335					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GCTGCACGATGAGAATCGGAA	0.488000													16	110					0	0	1	0	0
CCDC7	221016	broad.mit.edu	37	10	32751975	32751975	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr10:32751975G>A	ENST00000545067.1	+	6	804	c.508G>A	c.(508-510)Gaa>Aaa	p.E170K	CCDC7_ENST00000277657.6_Missense_Mutation_p.E170K|CCDC7_ENST00000537047.1_Missense_Mutation_p.E170K|CCDC7_ENST00000535327.1_Missense_Mutation_p.E170K|CCDC7_ENST00000362006.5_Missense_Mutation_p.E170K|CCDC7_ENST00000539197.1_Missense_Mutation_p.E170K			Q96M83	CCDC7_HUMAN	coiled-coil domain containing 7	170										NS(1)|breast(2)|cervix(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(2)	14		Breast(68;0.000207)|Prostate(175;0.0107)				TCAGATGGAAGAAGTAAGTCT	0.264000													6	37					0	0	1	0	0
SEMA6D	80031	broad.mit.edu	37	15	48063756	48063756	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr15:48063756G>A	ENST00000316364.5	+	19	3435	c.2996G>A	c.(2995-2997)gGa>gAa	p.G999E	SEMA6D_ENST00000389432.2_Missense_Mutation_p.G956E|SEMA6D_ENST00000389433.2_Missense_Mutation_p.G980E|SEMA6D_ENST00000354744.4_Missense_Mutation_p.G943E|SEMA6D_ENST00000558014.1_Missense_Mutation_p.G937E|SEMA6D_ENST00000355997.3_3'UTR|SEMA6D_ENST00000536845.2_Missense_Mutation_p.G999E|SEMA6D_ENST00000537942.1_Missense_Mutation_p.G937E|SEMA6D_ENST00000389428.3_Missense_Mutation_p.G924E|SEMA6D_ENST00000558816.1_3'UTR|SEMA6D_ENST00000358066.4_Missense_Mutation_p.G937E	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	999					axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		AACCGTGGAGGATATATGCCC	0.483000													15	113					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38824115	38824115	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:38824115C>T	ENST00000303592.3	-	2	281	c.23G>A	c.(22-24)gGc>gAc	p.G8D		NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	8					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					GTGGGCCTGGCCGTTGCGGCT	0.657000													7	476					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18600179	18600179	+	Missense_Mutation	SNP	T	T	A	rs45449301		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr18:18600179T>A	ENST00000399799.1	-	12	2234	c.1294A>T	c.(1294-1296)Atc>Ttc	p.I432F		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	432	Interaction with FHOD1.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					AGCTTATAGATTGTTTTTTGC	0.264000													7	64					0	0	1	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935675	151935675	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:151935675G>A	ENST00000393902.3	-	3	1059	c.492C>T	c.(490-492)atC>atT	p.I164I	MAGEA3_ENST00000370278.3_Silent_p.I164I			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	164	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					CCATCAGCTCGATGCCAAAGA	0.532000													6	214					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102516358	102516358	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:102516358G>C	ENST00000421544.1	+	16	3189	c.2699G>C	c.(2698-2700)aGg>aCg	p.R900T	GRIK2_ENST00000369138.1_3'UTR|GRIK2_ENST00000369134.4_Missense_Mutation_p.R851T|GRIK2_ENST00000369137.3_Missense_Mutation_p.R824T|GRIK2_ENST00000413795.1_3'UTR	NM_021956.4	NP_068775.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	900					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	AACGACAGAAGGTTGCCAGGT	0.443000													6	64					0	0	1	0	0
FBXO39	162517	broad.mit.edu	37	17	6683808	6683808	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:6683808C>T	ENST00000321535.4	+	2	751	c.621C>T	c.(619-621)caC>caT	p.H207H		NM_153230.2	NP_694962.1	Q8N4B4	FBX39_HUMAN	F-box protein 39	207										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	26						TCAGCCATCACCTTGCTGTCT	0.493000													4	58					0	0	1	0	0
SEMA4A	64218	broad.mit.edu	37	1	156126262	156126262	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:156126262C>T	ENST00000368285.3	+	3	464	c.197C>T	c.(196-198)aCt>aTt	p.T66I	SEMA4A_ENST00000487358.1_3'UTR|SEMA4A_ENST00000368284.1_5'UTR|SEMA4A_ENST00000368282.1_Missense_Mutation_p.T66I|SEMA4A_ENST00000355014.2_Missense_Mutation_p.T66I|SEMA4A_ENST00000368286.2_5'UTR	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	66	Sema.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					GATTTTGACACTCTGCTCCTG	0.537000													26	116					0	0	1	0	0
EDAR	10913	broad.mit.edu	37	2	109513507	109513507	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:109513507G>A	ENST00000409271.1	-	12	1742	c.1299C>T	c.(1297-1299)atC>atT	p.I433I	EDAR_ENST00000376651.1_Silent_p.I433I|EDAR_ENST00000258443.2_Silent_p.I401I			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	401					apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						CTGCCGTGCTGATGCGGTCAA	0.572000													16	27					0	0	1	0	0
MATR3	9782	broad.mit.edu	37	5	138657715	138657715	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:138657715G>A	ENST00000394800.2	+	14	2280	c.1731G>A	c.(1729-1731)ctG>ctA	p.L577L	MATR3_ENST00000504203.1_Silent_p.L239L|MATR3_ENST00000394805.3_Silent_p.L577L|MATR3_ENST00000502499.1_Silent_p.L239L|MATR3_ENST00000509990.1_Silent_p.L577L|MATR3_ENST00000361059.2_Silent_p.L577L|MATR3_ENST00000510056.1_Silent_p.L577L|MATR3_ENST00000503811.1_Silent_p.L289L|MATR3_ENST00000502929.1_Silent_p.L577L			P43243	MATR3_HUMAN	matrin 3	577						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AACTGGTTCTGAGGGTATGTA	0.338000													13	75					0	0	1	0	0
GPR155	151556	broad.mit.edu	37	2	175337792	175337792	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:175337792C>T	ENST00000392552.2	-	3	999	c.761G>A	c.(760-762)gGa>gAa	p.G254E	GPR155_ENST00000392551.2_Missense_Mutation_p.G254E|GPR155_ENST00000295500.4_Missense_Mutation_p.G254E	NM_001267051.1|NM_152529.6	NP_001253980.1|NP_689742.4	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155	254					intracellular signal transduction|transmembrane transport	integral to membrane				breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	26						TAGGGCTGATCCAGAAAAAGA	0.368000													17	123					0	0	1	0	0
GPR52	9293	broad.mit.edu	37	1	174417581	174417581	+	Nonsense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:174417581C>G	ENST00000367685.2	+	1	370	c.332C>G	c.(331-333)tCa>tGa	p.S111*	RABGAP1L_ENST00000367689.3_Intron|RABGAP1L_ENST00000251507.4_Intron|RABGAP1L_ENST00000357444.6_Intron	NM_005684.4	NP_005675.3	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	111						integral to plasma membrane	G-protein coupled receptor activity			breast(3)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|prostate(1)|skin(2)	20						GTCCACGAGTCATTGACTTGC	0.423000													21	315					0	0	1	0	0
ICA1	3382	broad.mit.edu	37	7	8257989	8257989	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:8257989G>A	ENST00000402384.3	-	6	791	c.525C>T	c.(523-525)gaC>gaT	p.D175D	ICA1_ENST00000401396.1_Silent_p.D163D|ICA1_ENST00000422063.2_Silent_p.D175D|ICA1_ENST00000406470.2_Silent_p.D175D|ICA1_ENST00000265577.7_Silent_p.D174D|ICA1_ENST00000396675.3_Silent_p.D175D|ICA1_ENST00000407906.1_Silent_p.D175D			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	175	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		CCTGAGACACGTCCTTCATCC	0.502000													38	91					0	0	1	0	0
ACRC	93953	broad.mit.edu	37	X	70823738	70823738	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:70823738C>T	ENST00000373695.1	+	7	1148	c.611C>T	c.(610-612)tCa>tTa	p.S204L	ACRC_ENST00000373696.3_Missense_Mutation_p.S204L			Q96QF7	ACRC_HUMAN	acidic repeat containing	204	Asp/Ser-rich.					nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					AGTGATGATTCATCCGACGAC	0.498000													71	397					0	0	1	0	0
ANGPTL1	9068	broad.mit.edu	37	1	178834309	178834309	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:178834309C>T	ENST00000234816.2	-	3	1050	c.603G>A	c.(601-603)ttG>ttA	p.L201L	RALGPS2_ENST00000324778.4_Intron|RALGPS2_ENST00000367634.2_Intron|ANGPTL1_ENST00000367629.1_Silent_p.L201L|RALGPS2_ENST00000367635.3_Intron	NM_004673.3	NP_004664.1	O95841	ANGL1_HUMAN	angiopoietin-like 1	201						extracellular space	receptor binding			breast(2)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)	14						AAAATATCCTCAAGCACTGTT	0.463000													5	214					0	0	1	0	0
EBF1	1879	broad.mit.edu	37	5	158522676	158522676	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:158522676C>T	ENST00000313708.6	-	4	645	c.363G>A	c.(361-363)agG>agA	p.R121R	EBF1_ENST00000518836.1_5'UTR|EBF1_ENST00000517373.1_Silent_p.R121R|EBF1_ENST00000380654.4_Silent_p.R121R	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	121					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCTGCTCCGTCCTTATCCCTA	0.453000			T	HMGA2	lipoma								10	42					0	0	1	0	0
GIPR	2696	broad.mit.edu	37	19	46181398	46181398	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:46181398G>A	ENST00000590918.1	+	12	1165	c.1066G>A	c.(1066-1068)Gtg>Atg	p.V356M	GIPR_ENST00000304207.8_Missense_Mutation_p.V320M|GIPR_ENST00000263281.3_Missense_Mutation_p.V356M	NM_000164.2	NP_000155.1	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	356					generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				endometrium(1)|kidney(2)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	12		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		CCACGAGGTGGTGTTTGCTCC	0.672000													10	27					0	0	1	0	0
ZNF567	163081	broad.mit.edu	37	19	37211354	37211354	+	Silent	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:37211354C>G	ENST00000585696.1	+	3	2865	c.1635C>G	c.(1633-1635)ctC>ctG	p.L545L	ZNF567_ENST00000392163.2_Silent_p.L545L|ZNF567_ENST00000360729.4_Silent_p.L545L|ZNF567_ENST00000588311.1_Silent_p.L545L|ZNF567_ENST00000536254.2_Silent_p.L576L|ZNF850_ENST00000589390.1_Intron			Q8N184	ZN567_HUMAN	zinc finger protein 567	576					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGTCATATCTCATTCATCATC	0.413000													12	87					0	0	1	0	0
ZHX1	11244	broad.mit.edu	37	8	124267234	124267234	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr8:124267234G>A	ENST00000395571.3	-	3	1570	c.953C>T	c.(952-954)tCt>tTt	p.S318F	ZHX1-C8ORF76_ENST00000357082.4_Intron|ZHX1_ENST00000297857.2_Missense_Mutation_p.S318F|ZHX1_ENST00000522655.1_Missense_Mutation_p.S318F	NM_001017926.2|NM_007222.4	NP_001017926.1|NP_009153.3	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	318	Required for dimerization.|Required for interaction with NFYA.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TGCTTGAGCAGAAAGAACTGT	0.413000													38	347					0	0	1	0	0
SPRY2	10253	broad.mit.edu	37	13	80911079	80911079	+	Silent	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr13:80911079T>C	ENST00000377102.1	-	2	1739	c.762A>G	c.(760-762)tcA>tcG	p.S254S	SPRY2_ENST00000540649.1_Silent_p.S254S|SPRY2_ENST00000377104.3_Silent_p.S254S			O43597	SPY2_HUMAN	sprouty homolog 2 (Drosophila)	254	Cys-rich.|SPR.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein kinase B signaling cascade	cytosol|microtubule|ruffle membrane	protein serine/threonine kinase activator activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	12	Medulloblastoma(90;0.18)	Acute lymphoblastic leukemia(28;0.218)|Breast(118;0.244)		GBM - Glioblastoma multiforme(99;0.0318)		CACCCATGGCTGACCATCGTG	0.473000													10	68					0	0	1	0	0
TTC14	151613	broad.mit.edu	37	3	180324050	180324050	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr3:180324050C>T	ENST00000412756.2	+	8	1008	c.939C>T	c.(937-939)atC>atT	p.I313I	TTC14_ENST00000382584.4_Silent_p.I313I|TTC14_ENST00000296015.4_Silent_p.I313I	NM_001042601.2	NP_001036066.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	313							RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			GTGTGAAGATCGGAGTTGACT	0.323000													8	140					0	0	1	0	0
OR10G3	26533	broad.mit.edu	37	14	22038630	22038630	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:22038630G>A	ENST00000303532.1	-	1	245	c.246C>T	c.(244-246)ctC>ctT	p.L82L		NM_001005465.1	NP_001005465.1	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G, member 3	82					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)	15	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		AGTTCATCATGAGGCGAGGGA	0.502000													6	41					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578262	7578262	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:7578262C>G	ENST00000420246.2	-	6	719	c.587G>C	c.(586-588)cGa>cCa	p.R196P	TP53_ENST00000413465.2_Missense_Mutation_p.R196P|TP53_ENST00000455263.2_Missense_Mutation_p.R196P|TP53_ENST00000359597.4_Missense_Mutation_p.R196P|TP53_ENST00000445888.2_Missense_Mutation_p.R196P|TP53_ENST00000574684.1_Intron|TP53_ENST00000269305.4_Missense_Mutation_p.R196P	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	196	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196P(18)|p.0?(8)|p.?(5)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.R196Q(3)|p.R103P(2)|p.R64P(2)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.P98_E105>Q(1)|p.R196L(1)|p.P59_E66>Q(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCTTCCACTCGGATAAGATG	0.547000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			34	26					0	0	1	0	0
CLEC12B	387837	broad.mit.edu	37	12	10167981	10167981	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:10167981G>A	ENST00000396502.1	+	4	668	c.540G>A	c.(538-540)gtG>gtA	p.V180V	RP11-133L14.5_ENST00000544225.1_RNA|CLEC12B_ENST00000338896.5_Silent_p.V180V	NM_205852.2	NP_995324.2	Q2HXU8	CL12B_HUMAN	C-type lectin domain family 12, member B	180	C-type lectin.					integral to membrane|plasma membrane	receptor activity|sugar binding			central_nervous_system(2)|large_intestine(2)|lung(5)	9						CCACCCTAGTGAAGATAGACA	0.363000													9	77					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1216992	1216992	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:1216992G>A	ENST00000304460.10	+	8	1161	c.1105G>A	c.(1105-1107)Gcc>Acc	p.A369T		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	369					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCGGTGCAACGCCTCCGACCC	0.617000													82	164					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62400972	62400972	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:62400972T>C	ENST00000346178.4	-	7	656	c.641A>G	c.(640-642)gAc>gGc	p.D214G	GANAB_ENST00000534779.1_Missense_Mutation_p.D100G|GANAB_ENST00000540933.1_Missense_Mutation_p.D95G|GANAB_ENST00000534422.1_5'UTR|GANAB_ENST00000356638.3_Missense_Mutation_p.D192G	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	192					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						CTCAGCTGGGTCTTTTGATCC	0.622000													5	86					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187177145	187177145	+	Splice_Site	SNP	G	G	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr4:187177145G>C	ENST00000264690.6	+	13	1676		c.e13-1		KLKB1_ENST00000513864.1_Splice_Site	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1						blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		TTATGTTTCAGAATTCCAAAA	0.338000													20	24					0	0	1	0	0
TRAPPC13	80006	broad.mit.edu	37	5	64931138	64931138	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:64931138G>A	ENST00000399438.3	+	2	402	c.57G>A	c.(55-57)ctG>ctA	p.L19L	TRAPPC13_ENST00000438419.2_Silent_p.L19L|TRAPPC13_ENST00000231526.4_Silent_p.L19L|TRAPPC13_ENST00000505553.1_Silent_p.L19L|TRAPPC13_ENST00000545191.1_Silent_p.L19L	NM_001093755.1|NM_024941.3	NP_001087224.1|NP_079217.2			trafficking protein particle complex 13																		TGATGCGGCTGACTAAGCCTA	0.363000													11	47					0	0	1	0	0
ATP6V0C	527	broad.mit.edu	37	16	2569686	2569686	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr16:2569686C>G	ENST00000330398.4	+	3	642	c.408C>G	c.(406-408)atC>atG	p.I136M	RP11-20I23.1_ENST00000564543.1_3'UTR|ATP6V0C_ENST00000565223.1_Missense_Mutation_p.I93M|ATP6C_ENST00000569317.1_Intron|ATP6V0C_ENST00000564973.1_Missense_Mutation_p.I93M	NM_001198569.1|NM_001694.3	NP_001185498.1|NP_001685.1	P27449	VATL_HUMAN	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	136					ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|interspecies interaction between organisms|transferrin transport	endosome membrane|integral to membrane|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|ubiquitin protein ligase binding			endometrium(1)|lung(1)|ovary(1)	3		Ovarian(90;0.17)				TGATTCTCATCTTCGCCGAGG	0.617000													18	94					0	0	1	0	0
SUV39H1	6839	broad.mit.edu	37	X	48565906	48565906	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:48565906G>A	ENST00000376687.3	+	6	1374	c.1184G>A	c.(1183-1185)cGg>cAg	p.R395Q	SUV39H1_ENST00000337852.6_Missense_Mutation_p.R406Q|SUV39H1_ENST00000482260.1_3'UTR|AF196970.3_ENST00000416061.1_RNA|SUV39H1_ENST00000453214.2_3'UTR	NM_003173.2	NP_003164.1	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1 (Drosophila)	395					cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	14						CCTAAGAAGCGGGTCCGTATT	0.592000													17	113					0	0	1	0	0
MAP3K8	1326	broad.mit.edu	37	10	30749638	30749638	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr10:30749638C>A	ENST00000263056.1	+	9	1973	c.1277C>A	c.(1276-1278)tCt>tAt	p.S426Y	MAP3K8_ENST00000375321.1_Missense_Mutation_p.S426Y|MAP3K8_ENST00000542547.1_Missense_Mutation_p.S426Y	NM_001244134.1|NM_005204.3	NP_001231063.1|NP_005195.2	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase 8	426			Missing (in oncogenic form).		cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Prostate(175;0.151)				TTTTCAGATTCTTCGTGCACA	0.438000													8	35					0.000157383	0.000161599	1	1	0
ZNF831	128611	broad.mit.edu	37	20	57767486	57767486	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr20:57767486G>A	ENST00000371030.2	+	1	1412	c.1412G>A	c.(1411-1413)cGc>cAc	p.R471H		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	471						intracellular	nucleic acid binding|zinc ion binding	p.R471L(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GGCCCCGTGCGCTCCACCTGG	0.672000													6	48					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113711342	113711342	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:113711342C>T	ENST00000003302.4	-	5	580	c.512G>A	c.(511-513)tGt>tAt	p.C171Y	USP28_ENST00000545540.1_Missense_Mutation_p.C46Y|USP28_ENST00000537706.1_Missense_Mutation_p.C171Y|USP28_ENST00000542033.1_5'UTR|USP28_ENST00000260188.5_Missense_Mutation_p.C171Y	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	171					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		ACTAAACCAACATGTATTGCC	0.373000													11	47					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57753888	57753888	+	Missense_Mutation	SNP	A	A	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr15:57753888A>C	ENST00000281282.5	+	8	2279	c.2201A>C	c.(2200-2202)cAg>cCg	p.Q734P		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	734						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		GAGCTCTTACAGGCAAAACAG	0.517000													26	114					0	0	1	0	0
TLK2	11011	broad.mit.edu	37	17	60663567	60663567	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:60663567G>A	ENST00000582809.1	+	17	1696	c.993G>A	c.(991-993)gaG>gaA	p.E331E	TLK2_ENST00000343388.7_Silent_p.E448E|TLK2_ENST00000326270.9_Silent_p.E502E|TLK2_ENST00000346027.5_Silent_p.E480E|TLK2_ENST00000542523.1_Silent_p.E448E			Q86UE8	TLK2_HUMAN	tousled-like kinase 2	502					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						GGAGAGATGAGAAAAAGGAGA	0.323000													8	67					0	0	1	0	0
FAM227B	196951	broad.mit.edu	37	15	49907342	49907342	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr15:49907342C>A	ENST00000299338.6	-	2	330	c.27G>T	c.(25-27)agG>agT	p.R9S	FAM227B_ENST00000560246.1_Missense_Mutation_p.R9S|FAM227B_ENST00000561064.1_Missense_Mutation_p.R9S|FAM227B_ENST00000558594.1_Missense_Mutation_p.R9S|FAM227B_ENST00000558862.1_5'UTR	NM_152647.2	NP_689860.2			family with sequence similarity 227, member B																		TGCTGCTCCTCCTTTGACATG	0.473000													24	134					4.72057e-08	4.9957e-08	1	1	0
XPO4	64328	broad.mit.edu	37	13	21357969	21357969	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr13:21357969G>A	ENST00000400602.2	-	23	3383	c.3348C>T	c.(3346-3348)ctC>ctT	p.L1116L	XPO4_ENST00000255305.6_Silent_p.L1116L	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	1116					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		TGCTTGCAGTGAGCTTGTTGA	0.433000													22	202					0	0	1	0	0
CDC16	8881	broad.mit.edu	37	13	115028376	115028376	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr13:115028376T>C	ENST00000360383.3	+	16	1597	c.1399T>C	c.(1399-1401)Tac>Cac	p.Y467H	CDC16_ENST00000375310.1_Missense_Mutation_p.Y373H|CDC16_ENST00000375312.3_Missense_Mutation_p.Y322H|CDC16_ENST00000252457.5_Missense_Mutation_p.Y466H|CDC16_ENST00000356221.3_Missense_Mutation_p.Y467H|CDC16_ENST00000252458.6_Missense_Mutation_p.Y322H|CDC16_ENST00000375308.1_Missense_Mutation_p.Y373H	NM_001078645.1|NM_003903.3	NP_001072113.1|NP_003894.3	Q13042	CDC16_HUMAN	cell division cycle 16	467					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding			endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)			GGCCTTGGATTACCACCGTCA	0.438000													15	151					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55798463	55798463	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:55798463G>A	ENST00000309383.1	+	2	502	c.225G>A	c.(223-225)ctG>ctA	p.L75L	BRSK1_ENST00000590333.1_Silent_p.L91L|BRSK1_ENST00000585418.1_Silent_p.L75L	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	75	Protein kinase.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		AGTCGGTGCTGATGAAGGTGT	0.662000													15	59					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102508995	102508995	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:102508995G>A	ENST00000360184.4	+	69	12587	c.12423G>A	c.(12421-12423)gcG>gcA	p.A4141A	RP11-1017G21.4_ENST00000557242.1_RNA|RP11-1017G21.4_ENST00000557551.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	4141	AAA 6 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TGCTCCGTGCGGGCCGCATCT	0.587000													6	60					0	0	1	0	0
GNA14	9630	broad.mit.edu	37	9	80046346	80046346	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:80046346G>A	ENST00000341700.6	-	4	997	c.484C>T	c.(484-486)Cgc>Tgc	p.R162C	GNA14_ENST00000464095.1_5'UTR	NM_004297.3	NP_004288.1	O95837	GNA14_HUMAN	guanine nucleotide binding protein (G protein), alpha 14	162					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	24						GTGGCGATGCGGTCAATGTCA	0.498000													12	74					0	0	1	0	0
STOML3	161003	broad.mit.edu	37	13	39541122	39541122	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr13:39541122G>A	ENST00000379631.4	-	7	1060	c.716C>T	c.(715-717)gCt>gTt	p.A239V	STOML3_ENST00000423210.1_Missense_Mutation_p.A230V	NM_145286.2	NP_660329.1	Q8TAV4	STML3_HUMAN	stomatin (EPB72)-like 3	239						integral to membrane|plasma membrane				breast(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	11		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		GGGAGACTCAGCCAGCACCAT	0.468000													4	66					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23548064	23548064	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr14:23548064C>T	ENST00000262710.1	-	7	2473	c.2146G>A	c.(2146-2148)Gaa>Aaa	p.E716K	ACIN1_ENST00000457657.1_Missense_Mutation_p.E676K|ACIN1_ENST00000605057.1_Missense_Mutation_p.E658K|ACIN1_ENST00000555053.1_Missense_Mutation_p.E716K|ACIN1_ENST00000555352.1_5'UTR	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	716					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ACATGCTTTTCAGCTGATTCA	0.532000													6	48					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84525922	84525922	+	Silent	SNP	T	T	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:84525922T>A	ENST00000360700.4	+	10	2398	c.1512T>A	c.(1510-1512)gcT>gcA	p.A504A	ZNF711_ENST00000373165.3_Silent_p.A458A|ZNF711_ENST00000276123.3_Silent_p.A458A|ZNF711_ENST00000395402.1_Silent_p.A466A|ZNF711_ENST00000542798.1_Silent_p.A300A			Q9Y462	ZN711_HUMAN	zinc finger protein 711	458					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						ACAGAGAGGCTAGTCCACTGA	0.383000													8	35					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209710	140209710	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:140209710G>A	ENST00000529310.1	+	1	2148	c.2034G>A	c.(2032-2034)gcG>gcA	p.A678A	PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCAAAGGCGTCATCACGGG	0.677000													18	81					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21730847	21730847	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:21730847G>T	ENST00000584755.1	+	2	546	c.149G>T	c.(148-150)cGg>cTg	p.R50L	UBBP4_ENST00000578713.1_Missense_Mutation_p.R50L|UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000583708.1_Intron																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GGCAAGCAGCGGGAAGATGGC	0.522000													4	58					0.00909568	0.00912212	1	1	0
BAI2	576	broad.mit.edu	37	1	32198168	32198168	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:32198168C>T	ENST00000373658.3	-	27	4011	c.3670G>A	c.(3670-3672)Gag>Aag	p.E1224K	BAI2_ENST00000465256.1_5'UTR|BAI2_ENST00000398538.1_Missense_Mutation_p.E1212K|BAI2_ENST00000373655.2_Missense_Mutation_p.E1224K|BAI2_ENST00000398547.1_Missense_Mutation_p.E1157K|BAI2_ENST00000440175.2_Missense_Mutation_p.E833K|BAI2_ENST00000398556.3_Missense_Mutation_p.E1139K|BAI2_ENST00000257070.4_Missense_Mutation_p.E1191K|BAI2_ENST00000398542.1_Missense_Mutation_p.E1124K|BAI2_ENST00000527361.1_Missense_Mutation_p.E1191K	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	1224					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		TCTTCGCTCTCATCAGCCCGG	0.667000													4	58					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108863391	108863391	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr13:108863391C>T	ENST00000356922.4	-	2	498	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K	LIG4_ENST00000405925.1_Missense_Mutation_p.E76K|LIG4_ENST00000442234.1_Missense_Mutation_p.E76K	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	76					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					CTCTCTCTTTCTAGCTGAGGA	0.353000								Non-homologous end-joining					18	151					0	0	1	0	0
RBPJL	11317	broad.mit.edu	37	20	43945591	43945591	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr20:43945591C>A	ENST00000343694.3	+	12	1618	c.1546C>A	c.(1546-1548)Cag>Aag	p.Q516K	RBPJL_ENST00000372743.1_Missense_Mutation_p.Q515K|RBPJL_ENST00000372741.3_3'UTR|RBPJL_ENST00000464504.1_3'UTR	NM_014276.2	NP_055091.2	Q9UBG7	RBPJL_HUMAN	recombination signal binding protein for immunoglobulin kappa J region-like	516					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Myeloproliferative disorder(115;0.0122)				CCTCTTCATCCAGACTTAGGC	0.706000													31	94					8.16721e-17	8.86065e-17	1	1	0
CCDC67	159989	broad.mit.edu	37	11	93065448	93065448	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:93065448C>T	ENST00000298050.3	+	2	123	c.23C>T	c.(22-24)aCg>aTg	p.T8M	CCDC67_ENST00000527307.1_Missense_Mutation_p.T8M|CCDC67_ENST00000530273.1_Missense_Mutation_p.T8M|CCDC67_ENST00000530053.1_3'UTR	NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	8										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				GCCCATAATACGATGGGGTAA	0.323000													4	17					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222515	140222515	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:140222515G>A	ENST00000531613.1	+	1	1609	c.1609G>A	c.(1609-1611)Gcg>Acg	p.A537T	PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.A537T|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGGTGAGCGCGCGCGACGC	0.667000													27	155					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24522815	24522815	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:24522815C>T	ENST00000355123.4	-	12	1750	c.1307G>A	c.(1306-1308)cGa>cAa	p.R436Q	ITSN2_ENST00000361999.3_Missense_Mutation_p.R436Q|ITSN2_ENST00000406921.3_Missense_Mutation_p.R436Q	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	436					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCTTCCTCTCGTTGTCTCTC	0.328000													5	108					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37382282	37382282	+	Missense_Mutation	SNP	C	C	T	rs146510671		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:37382282C>T	ENST00000310758.4	-	2	660	c.13G>A	c.(13-15)Gcg>Acg	p.A5T	ELMO1_ENST00000448602.1_Missense_Mutation_p.A5T|ELMO1_ENST00000442504.1_Missense_Mutation_p.A5T	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	5					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding	p.A5T(1)		breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						ACGATGTCCGCGGGTGGCGGC	0.502000													25	175					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31324973	31324973	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr15:31324973G>A	ENST00000542188.1	-	21	3235	c.2922C>T	c.(2920-2922)atC>atT	p.I974I	TRPM1_ENST00000397795.2_Silent_p.I935I|RP11-348B17.1_ENST00000561299.1_RNA|RP11-348B17.1_ENST00000558755.1_RNA|TRPM1_ENST00000256552.6_Silent_p.I957I	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	935					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		ACCAGAAGATGATATCCACAC	0.483000													17	93					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6103696	6103696	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:6103696C>T	ENST00000261405.5	-	36	6395	c.6141G>A	c.(6139-6141)atG>atA	p.M2047I		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2047	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TGACCTCATGCATGATGGCAC	0.468000													13	84					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110450115	110450115	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:110450115C>G	ENST00000260283.4	-	16	3839	c.3555G>C	c.(3553-3555)agG>agC	p.R1185S	ARHGAP20_ENST00000533353.1_Missense_Mutation_p.R1159S|ARHGAP20_ENST00000528829.1_Missense_Mutation_p.R1149S|ARHGAP20_ENST00000529591.1_Splice_Site|ARHGAP20_ENST00000524756.1_Missense_Mutation_p.R1162S|ARHGAP20_ENST00000527598.1_Missense_Mutation_p.R1149S|ARHGAP20_ENST00000357139.3_Missense_Mutation_p.R1159S	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	1185					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TGGTTAAATACCTGTCCTCAA	0.443000													5	116					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55356450	55356450	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:55356450C>G	ENST00000524622.1	-	7	1479	c.818G>C	c.(817-819)aGa>aCa	p.R273T	TESPA1_ENST00000316577.8_Missense_Mutation_p.R411T|TESPA1_ENST00000532804.1_Missense_Mutation_p.R273T|TESPA1_ENST00000531122.1_Missense_Mutation_p.R273T|TESPA1_ENST00000449076.1_Missense_Mutation_p.R411T	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	411																	ACACAGCTCTCTCCTTATCTG	0.507000													22	103					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70488940	70488940	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:70488940G>A	ENST00000310961.5	+	18	1996	c.1578G>A	c.(1576-1578)caG>caA	p.Q526Q	RP11-181B18.1_ENST00000414132.1_RNA|LRRC7_ENST00000415775.2_Intron|LRRC7_ENST00000035383.5_Silent_p.Q521Q			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	521						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CCGTCCCCCAGAATGACCCAC	0.562000													8	71					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530760	140530760	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:140530760G>A	ENST00000231136.1	+	1	922	c.922G>A	c.(922-924)Gag>Aag	p.E308K	PCDHB6_ENST00000543635.1_Missense_Mutation_p.E172K	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		308	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTGGATTTTGAGGAAATTCA	0.458000													17	63					0	0	1	0	0
CUL4B	8450	broad.mit.edu	37	X	119670819	119670819	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:119670819G>T	ENST00000371322.5	-	15	2070	c.2009C>A	c.(2008-2010)cCg>cAg	p.P670Q	CUL4B_ENST00000404115.3_Missense_Mutation_p.P688Q|CUL4B_ENST00000336592.6_Missense_Mutation_p.P675Q	NM_001079872.1	NP_001073341.1	Q13620	CUL4B_HUMAN	cullin 4B	688					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						CACATATGTCGGCCAATAGCC	0.373000													26	140					9.80776e-20	1.06741e-19	1	1	0
KANK4	163782	broad.mit.edu	37	1	62739257	62739257	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:62739257C>T	ENST00000371153.4	-	3	1897	c.1519G>A	c.(1519-1521)Gaa>Aaa	p.E507K	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	507										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						CCTTCCTGTTCAGTGCCTGCT	0.597000													11	73					0	0	1	0	0
APOL1	8542	broad.mit.edu	37	22	36662064	36662064	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:36662064G>A	ENST00000319136.4	+	7	1497	c.1230G>A	c.(1228-1230)gcG>gcA	p.A410A	APOL1_ENST00000397278.3_Silent_p.A394A|APOL1_ENST00000397279.4_Silent_p.A394A|APOL1_ENST00000426053.1_Silent_p.A376A|APOL1_ENST00000347595.7_Silent_p.A273A|APOL1_ENST00000422706.1_Silent_p.A394A	NM_145343.2	NP_663318.1	O14791	APOL1_HUMAN	apolipoprotein L, 1	394					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	14						TTCTGCAGGCGGACCAAGAAC	0.498000													4	79					0	0	1	0	0
SMUG1	23583	broad.mit.edu	37	12	54576029	54576029	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:54576029G>A	ENST00000508394.2	-	3	726	c.664C>T	c.(664-666)Cga>Tga	p.R222*	SMUG1_ENST00000401977.2_Nonsense_Mutation_p.R222*|SMUG1_ENST00000337581.3_Nonsense_Mutation_p.R222*|SMUG1_ENST00000513838.1_Intron|SMUG1_ENST00000505662.1_5'UTR|SMUG1_ENST00000505128.1_3'UTR|SMUG1_ENST00000514685.1_Intron|SMUG1_ENST00000514196.1_Intron|SMUG1_ENST00000243112.5_Intron|SMUG1_ENST00000506595.1_Intron	NM_001243787.1|NM_001243788.1|NM_014311.2	NP_001230716.1|NP_001230717.1|NP_055126.1	Q53HV7	SMUG1_HUMAN	single-strand-selective monofunctional uracil-DNA glycosylase 1	222					depyrimidination	nucleolus|nucleoplasm	DNA binding|protein binding|single-strand selective uracil DNA N-glycosylase activity			kidney(1)|large_intestine(4)|lung(1)	6						AGAGCCCGTCGTGCCCGCTGC	0.672000								Base excision repair (BER), DNA glycosylases					24	38					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53562351	53562351	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:53562351T>C	ENST00000342160.3	-	80	13100	c.12643A>G	c.(12643-12645)Atg>Gtg	p.M4215V	HUWE1_ENST00000262854.6_Missense_Mutation_p.M4215V			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	4215	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CTACCTGTCATTCTCATCTGG	0.438000													8	51					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	44083443	44083443	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:44083443G>A	ENST00000262726.7	-	11	1303	c.1050C>T	c.(1048-1050)acC>acT	p.T350T	EFCAB6_ENST00000358439.4_Intron|EFCAB6_ENST00000396231.2_Silent_p.T198T	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TGATTTTAGTGGTGGCTTTAA	0.328000													34	101					0	0	1	0	0
PXN	5829	broad.mit.edu	37	12	120653789	120653789	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:120653789G>A	ENST00000397506.3	-	3	1120	c.67C>T	c.(67-69)Cca>Tca	p.P23S	PXN_ENST00000228307.7_Intron|PXN_ENST00000538144.1_Intron|PXN_ENST00000424649.2_Intron|PXN_ENST00000536957.1_Intron|PXN_ENST00000458477.2_Intron|PXN_ENST00000267257.7_Intron			P49023	PAXI_HUMAN	paxillin	100					cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCCCTTCTGGAGTGGCTTCT	0.632000													3	17					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	50					0	0	1	0	0
LCP1	3936	broad.mit.edu	37	13	46717512	46717512	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr13:46717512G>T	ENST00000398576.2	-	15	1669	c.1281C>A	c.(1279-1281)ttC>ttA	p.F427L	LCP1_ENST00000323076.2_Missense_Mutation_p.F427L			P13796	PLSL_HUMAN	lymphocyte cytosolic protein 1 (L-plastin)	427	Actin-binding 2.|CH 3.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			breast(2)|kidney(1)|large_intestine(6)|lung(18)|ovary(4)|prostate(2)|skin(1)	34		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		CATAGAGCTGGAAGATGACCA	0.418000			T	BCL6	NHL								7	93					8.12818e-05	8.39588e-05	1	1	0
TAS2R40	259286	broad.mit.edu	37	7	142919262	142919262	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:142919262A>G	ENST00000408947.3	+	1	133	c.91A>G	c.(91-93)Act>Gct	p.T31A	AC073342.1_ENST00000595842.1_Silent_p.S33S	NM_176882.1	NP_795363.1	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	31					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8	Melanoma(164;0.059)					AGAGTGCATCACTGGCATCCT	0.512000													15	89					0	0	1	0	0
ANKEF1	63926	broad.mit.edu	37	20	10023851	10023851	+	Missense_Mutation	SNP	A	A	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr20:10023851A>T	ENST00000378380.3	+	3	757	c.428A>T	c.(427-429)aAc>aTc	p.N143I	SNAP25-AS1_ENST00000603542.1_RNA|ANKEF1_ENST00000378392.1_Missense_Mutation_p.N143I|ANKEF1_ENST00000488991.1_3'UTR|SNAP25-AS1_ENST00000421143.2_RNA	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		GCAGATGTCAACAATTCTACC	0.408000													72	100					0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95768696	95768696	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:95768696G>A	ENST00000311106.3	-	1	288	c.51C>T	c.(49-51)tgC>tgT	p.C17C	CTD-2337A12.1_ENST00000502645.2_RNA	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	17					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CACACCAAGCGCAAAAGAGGA	0.557000													37	139					0	0	1	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138437534	138437534	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:138437534C>A	ENST00000310018.2	-	11	1147	c.865G>T	c.(865-867)Gct>Tct	p.A289S	ATP6V0A4_ENST00000353492.4_Missense_Mutation_p.A289S|ATP6V0A4_ENST00000393054.1_Missense_Mutation_p.A289S	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	289					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CAGTTGGCAGCGGCTTCCTGC	0.502000													26	62					1.39806e-14	1.512e-14	1	1	0
UBTF	7343	broad.mit.edu	37	17	42289000	42289000	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:42289000C>A	ENST00000302904.4	-	10	1513	c.1021G>T	c.(1021-1023)Gac>Tac	p.D341Y	UBTF_ENST00000343638.5_Missense_Mutation_p.D304Y|UBTF_ENST00000526094.1_Missense_Mutation_p.D304Y|UBTF_ENST00000436088.1_Missense_Mutation_p.D341Y|UBTF_ENST00000393606.3_Missense_Mutation_p.D304Y|CTB-175E5.7_ENST00000586560.1_RNA|UBTF_ENST00000533177.1_Missense_Mutation_p.D304Y|UBTF_ENST00000527034.1_Missense_Mutation_p.D304Y|UBTF_ENST00000529383.1_Missense_Mutation_p.D341Y			P17480	UBF1_HUMAN	upstream binding transcription factor, RNA polymerase I	341					positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(10)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		TGATAGGCGTCCTTCTCCTTC	0.582000													12	139					3.07112e-06	3.21071e-06	1	1	0
ATP6V0C	527	broad.mit.edu	37	16	2569364	2569364	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr16:2569364C>G	ENST00000564543.1	+	2	1228	c.1111C>G	c.(1111-1113)Cat>Gat	p.H371D	ATP6V0C_ENST00000565223.1_Silent_p.L32L|ATP6V0C_ENST00000330398.4_Silent_p.L75L|ATP6C_ENST00000569317.1_Intron|ATP6V0C_ENST00000564973.1_Silent_p.L32L|ATP6V0C_ENST00000568562.1_Missense_Mutation_p.H58D																							TGGCAGTCCTCATCGCCAACT	0.622000													6	74					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184043143	184043143	+	Silent	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr3:184043143C>T	ENST00000342981.4	+	18	3360	c.2946C>T	c.(2944-2946)gaC>gaT	p.D982D	EIF4G1_ENST00000434061.2_Silent_p.D786D|EIF4G1_ENST00000352767.3_Silent_p.D988D|EIF4G1_ENST00000441154.1_Silent_p.D818D|EIF4G1_ENST00000392537.2_Silent_p.D894D|EIF4G1_ENST00000424196.1_Silent_p.D988D|EIF4G1_ENST00000319274.6_Silent_p.D981D|EIF4G1_ENST00000382330.3_Silent_p.D988D|EIF4G1_ENST00000411531.1_Silent_p.D942D|EIF4G1_ENST00000346169.2_Silent_p.D981D|EIF4G1_ENST00000427845.1_Silent_p.D895D|EIF4G1_ENST00000414031.1_Silent_p.D941D|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000350481.5_Silent_p.D817D|EIF4G1_ENST00000435046.2_Silent_p.D785D	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	981	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCTGCAGGACGTGCTGGATC	0.522000													38	195					0	0	1	0	0
RNF40	9810	broad.mit.edu	37	16	30775583	30775583	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr16:30775583G>A	ENST00000324685.6	+	5	961	c.526G>A	c.(526-528)Gag>Aag	p.E176K	RNF40_ENST00000357890.5_Missense_Mutation_p.E176K|RNF40_ENST00000402121.3_Intron|RNF40_ENST00000563683.1_Missense_Mutation_p.E176K	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586.1	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	176					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			CAGCAGTGAGGAGGTGGAGCT	0.627000													4	17					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131339447	131339447	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:131339447G>A	ENST00000372739.3	+	7	935	c.825G>A	c.(823-825)gaG>gaA	p.E275E	SPTAN1_ENST00000372731.4_Silent_p.E275E|SPTAN1_ENST00000358161.5_Silent_p.E275E	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	275					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						AGGAAAAGGAGCAGTTAATGG	0.488000													27	213					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113169072	113169072	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:113169072G>T	ENST00000401783.2	-	38	9144	c.8808C>A	c.(8806-8808)aaC>aaA	p.N2936K	SVEP1_ENST00000374469.1_Missense_Mutation_p.N2913K|SVEP1_ENST00000297826.5_Missense_Mutation_p.N862K	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2936	Sushi 25.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTGCATCCCAGTTGCCATCTG	0.493000													218	98					2.91285e-89	3.21065e-89	1	1	0
UPF1	5976	broad.mit.edu	37	19	18974385	18974385	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:18974385C>G	ENST00000262803.5	+	19	3011	c.2739C>G	c.(2737-2739)ttC>ttG	p.F913L	UPF1_ENST00000599848.1_Missense_Mutation_p.F924L	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	924					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						TCATGCAGTTCAGCAAGCCAC	0.592000													9	56					0	0	1	0	0
FXYD5	53827	broad.mit.edu	37	19	35657174	35657174	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr19:35657174C>T	ENST00000342879.3	+	7	1211	c.433C>T	c.(433-435)Cgg>Tgg	p.R145W	FXYD5_ENST00000392217.3_Missense_Mutation_p.R74W|FXYD5_ENST00000588699.1_Missense_Mutation_p.R145W|FXYD5_ENST00000423817.3_Missense_Mutation_p.R145W|FXYD5_ENST00000591716.2_3'UTR|FXYD5_ENST00000543307.1_Missense_Mutation_p.R145W|FXYD5_ENST00000541435.2_Missense_Mutation_p.R145W|FXYD5_ENST00000392219.2_Missense_Mutation_p.R145W|FXYD5_ENST00000590686.1_Missense_Mutation_p.R145W			Q96DB9	FXYD5_HUMAN	FXYD domain containing ion transport regulator 5	145					microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CCTCCGGAAACGGGGGCTGTT	0.552000													91	221					0	0	1	0	0
IGLV3-21	28796	broad.mit.edu	37	22	23055573	23055573	+	RNA	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:23055573G>A	ENST00000390308.2	+	0	487																											ATCCCTGAGCGATTCTCTGGC	0.577000													26	78					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196684847	196684847	+	Silent	SNP	T	T	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:196684847T>A	ENST00000367429.4	+	11	1884	c.1644T>A	c.(1642-1644)acT>acA	p.T548T		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	548	Sushi 9.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						GAAGCACCACTGGTTCCATAG	0.353000													6	190					0	0	1	0	0
NFE2L2	4780	broad.mit.edu	37	2	178095546	178095546	+	Silent	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr2:178095546G>A	ENST00000397062.3	-	5	2339	c.1785C>T	c.(1783-1785)ccC>ccT	p.P595P	NFE2L2_ENST00000397063.4_Silent_p.P579P|NFE2L2_ENST00000464747.1_Silent_p.P579P|NFE2L2_ENST00000446151.2_Silent_p.P572P	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	595					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCTTACTTTTGGGAACAAGGA	0.373000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			10	148					0	0	1	0	0
HNRNPR	10236	broad.mit.edu	37	1	23645003	23645003	+	Silent	SNP	T	T	C			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:23645003T>C	ENST00000478691.1	-	7	967	c.696A>G	c.(694-696)gaA>gaG	p.E232E	HNRNPR_ENST00000427764.2_Silent_p.E292E|HNRNPR_ENST00000426846.2_Silent_p.E170E|HNRNPR_ENST00000606561.1_Silent_p.E191E|HNRNPR_ENST00000374612.1_Silent_p.E330E|HNRNPR_ENST00000374616.3_Silent_p.E333E|HNRNPR_ENST00000302271.6_Silent_p.E330E	NM_001102397.1|NM_001102399.1	NP_001095867.1|NP_001095869.1	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	330	RRM 1.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		GATCTGGTTCTTCCACAGGGT	0.428000													76	52					0	0	1	0	0
AP4E1	23431	broad.mit.edu	37	15	51240332	51240332	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr15:51240332G>A	ENST00000261842.5	+	11	1398	c.1292G>A	c.(1291-1293)gGc>gAc	p.G431D	AP4E1_ENST00000560508.1_Missense_Mutation_p.G356D	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	431					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		AATTTGGTCGGCAAAATAGCA	0.338000													4	72					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92543192	92543192	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:92543192C>G	ENST00000298047.6	+	12	9448	c.9431C>G	c.(9430-9432)aCa>aGa	p.T3144R	FAT3_ENST00000525166.1_Missense_Mutation_p.T2994R|FAT3_ENST00000409404.2_Missense_Mutation_p.T3144R			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3144	Cadherin 29.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TATGAGAACACAGCCACCAAG	0.507000										TCGA Ovarian(4;0.039)			51	29					0	0	1	0	0
INPP5E	56623	broad.mit.edu	37	9	139333155	139333155	+	Silent	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:139333155C>A	ENST00000371712.3	-	1	1119	c.717G>T	c.(715-717)ccG>ccT	p.P239P		NM_019892.4	NP_063945.2	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase, 72 kDa	239	13 X 4 AA repeats of P-X-X-P.					cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			NS(1)|endometrium(1)|lung(4)|skin(3)	9		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		GGGGGCTCCGCGGCCGGCCGG	0.687000													6	20					0.00116845	0.00119264	1	1	0
OR10A5	144124	broad.mit.edu	37	11	6867255	6867255	+	Silent	SNP	C	C	T	rs150623430	byFrequency	TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr11:6867255C>T	ENST00000299454.4	+	1	373	c.342C>T	c.(340-342)ttC>ttT	p.F114F	OR10A5_ENST00000379831.2_Silent_p.F118F			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTGAATGCTTCCTCCTGGCTA	0.532000													18	124					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110763396	110763396	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:110763396C>G	ENST00000451085.1	+	4	1614	c.568C>G	c.(568-570)Cta>Gta	p.L190V	IMMP2L_ENST00000450877.1_Intron|IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000331762.3_Intron|LRRN3_ENST00000422987.3_Missense_Mutation_p.L190V|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000405709.2_Intron|LRRN3_ENST00000308478.5_Missense_Mutation_p.L190V|IMMP2L_ENST00000415362.1_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	190						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		TCTTCCAAATCTAGAGATTCT	0.373000													18	105					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106524653	106524653	+	Silent	SNP	A	A	G			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr7:106524653A>G	ENST00000359195.3	+	9	3124	c.2814A>G	c.(2812-2814)gcA>gcG	p.A938A	PIK3CG_ENST00000496166.1_Silent_p.A938A|PIK3CG_ENST00000440650.2_Silent_p.A938A	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	938	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						ACTGTGTGGCAACCTTTGTTC	0.358000													27	148					0	0	1	0	0
GMEB1	10691	broad.mit.edu	37	1	29040842	29040842	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr1:29040842C>A	ENST00000373816.1	+	10	1387	c.1249C>A	c.(1249-1251)Ctc>Atc	p.L417I	GMEB1_ENST00000294409.2_Missense_Mutation_p.L427I|GMEB1_ENST00000361872.4_Missense_Mutation_p.L417I|GMEB1_ENST00000480454.1_3'UTR	NM_024482.2	NP_077808.1	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding protein 1	427					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)	11		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		AGTGGCCACCCTCAGCCAGGG	0.577000													4	68					0.00909568	0.00912212	1	1	0
MTAP	4507	broad.mit.edu	37	9	21861974	21861974	+	Splice_Site	SNP	G	G	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:21861974G>A	ENST00000380172.4	+	8	1019		c.e8-1		RP11-145E5.5_ENST00000404796.2_Intron|MTAP_ENST00000460874.2_Splice_Site|MTAP_ENST00000580900.1_Intron	NM_002451.3	NP_002442.2	Q13126	MTAP_HUMAN	methylthioadenosine phosphorylase						nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity	p.0(1)|p.0?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|lung(3)|pancreas(1)	10		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	CTTCCTTTCAGAATATGGCCC	0.353000													26	155					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36103497	36103497	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:36103497C>A	ENST00000378660.1	+	5	671	c.483C>A	c.(481-483)gaC>gaA	p.D161E	CHDC2_ENST00000313548.4_Missense_Mutation_p.D161E					calponin homology domain containing 2																		GACAGAATGACTTTTCCAAAT	0.343000													19	75					1.96895e-08	2.09011e-08	1	1	0
LMBRD2	92255	broad.mit.edu	37	5	36122429	36122431	+	In_Frame_Del	DEL	GGC	GGC	-			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr5:36122429_36122431delGGC	ENST00000296603.4	-	9	1533_1535	c.1071_1073delGCC	c.(1069-1074)tca>tc	p.SP357del		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	357						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTCTGGCTCTGGCGATTGAAAGG	0.300													12	104	---	---	---	---					
PDCD2	5134	broad.mit.edu	37	6	170888047	170888048	+	Frame_Shift_Ins	INS	-	-	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr6:170888047_170888048insT	ENST00000541970.1	-	5	851_852	c.773_774insA	c.(772-774)tggfs	p.W258fs	PDCD2_ENST00000392090.2_Frame_Shift_Ins_p.W225fs|PDCD2_ENST00000542896.1_Frame_Shift_Ins_p.W258fs	NM_001199462.1|NM_002598.3	NP_001186391.1|NP_002589.2	Q16342	PDCD2_HUMAN	programmed cell death 2	258					apoptosis	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(1)|lung(5)	9		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|BRCA - Breast invasive adenocarcinoma(81;4.82e-06)|GBM - Glioblastoma multiforme(31;0.142)		TACCTCTGCCATATCTAAGAAT	0.376													13	108	---	---	---	---					
MTMR7	9108	broad.mit.edu	37	8	17206567	17206569	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr8:17206567_17206569delTTC	ENST00000180173.5	-	5	524_526	c.490_492delGAA	c.(490-492)del	p.E164del	MTMR7_ENST00000523571.1_5'UTR|MTMR7_ENST00000521857.1_In_Frame_Del_p.E164del	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	164	Myotubularin phosphatase.						protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		GAACGTACAGTTCAGTAGGATAA	0.453													13	210	---	---	---	---					
HAS2	3037	broad.mit.edu	37	8	122641022	122641023	+	Frame_Shift_Ins	INS	-	-	T			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr8:122641022_122641023insT	ENST00000303924.4	-	2	1095_1096	c.558_559insA	c.(556-561)aaggggfs	p.KG186fs		NM_005328.2	NP_005319.1	Q92819	HAS2_HUMAN	hyaluronan synthase 2	186						integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(19)|ovary(5)|skin(1)	38	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			TTTCCACCCCATTTTTGCATGA	0.465													98	313	---	---	---	---					
CAMSAP1	157922	broad.mit.edu	37	9	138715799	138715800	+	Frame_Shift_Ins	INS	-	-	T	rs148250832	byFrequency	TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr9:138715799_138715800insT	ENST00000389532.4	-	10	1460_1461	c.1396_1397insA	c.(1396-1398)cagfs	p.Q466fs	CAMSAP1_ENST00000409386.3_Frame_Shift_Ins_p.Q477fs|CAMSAP1_ENST00000483991.1_5'UTR|CAMSAP1_ENST00000312405.6_Frame_Shift_Ins_p.Q188fs	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	466						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GACTCACCTGGTTTTTTTTTCT	0.460													5	11	---	---	---	---					
AGAP11	119385	broad.mit.edu	37	10	88767879	88767880	+	RNA	INS	-	-	T	rs71019447		TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr10:88767879_88767880insT	ENST00000444431.1	+	0	2711				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										ttttttctttcttttttttttt	0.455													5	1	---	---	---	---					
ANKLE2	23141	broad.mit.edu	37	12	133303901	133303901	+	Frame_Shift_Del	DEL	G	G	-			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr12:133303901delG	ENST00000539605.1	-	12	9242	c.2558delC	c.(2557-2559)ctfs	p.P853fs	ANKLE2_ENST00000357997.5_Frame_Shift_Del_p.P915fs|ANKLE2_ENST00000542374.1_5'UTR|ANKLE2_ENST00000542657.1_Frame_Shift_Del_p.P270fs|ANKLE2_ENST00000542282.1_Frame_Shift_Del_p.P270fs			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	915						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		GTAGCGCCCAGGACTGCCCAG	0.657													2	4	---	---	---	---					
ITGAL	3683	broad.mit.edu	37	16	30531249	30531251	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr16:30531249_30531251delGCT	ENST00000356798.6	+	30	3480_3482	c.3300_3302delGCT	c.(3298-3303)ggg>gg	p.GL1100del	ITGAL_ENST00000433423.2_In_Frame_Del_p.GL334del|ITGAL_ENST00000358164.5_In_Frame_Del_p.GL1016del	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	1100					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GCATCGGGGGGCTGCTGCTGCTG	0.601													7	295	---	---	---	---					
ELP5	23587	broad.mit.edu	37	17	7157966	7157966	+	Frame_Shift_Del	DEL	G	G	-			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr17:7157966delG	ENST00000574993.1	+	4	518	c.301delG	c.(301-303)ggfs	p.G102fs	ELP5_ENST00000354429.2_Frame_Shift_Del_p.G102fs|ELP5_ENST00000396627.2_Frame_Shift_Del_p.G102fs|ELP5_ENST00000573657.1_Frame_Shift_Del_p.G102fs|ELP5_ENST00000574255.1_Frame_Shift_Del_p.G102fs|RP1-4G17.5_ENST00000577138.1_Intron|ELP5_ENST00000356683.2_Frame_Shift_Del_p.G102fs|ELP5_ENST00000396628.2_Frame_Shift_Del_p.G102fs					elongator acetyltransferase complex subunit 5																		GGCCTTTCCTGGGGGGCCGCT	0.512													9	67	---	---	---	---					
BIK	638	broad.mit.edu	37	22	43525245	43525247	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chr22:43525245_43525247delGCT	ENST00000216115.2	+	5	480_482	c.417_419delGCT	c.(415-420)gcg>gc	p.AL139del		NM_001197.4	NP_001188.1	Q13323	BIK_HUMAN	BCL2-interacting killer (apoptosis-inducing)	139	Leucine-zipper (Potential).				apoptosis|induction of apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	endomembrane system|integral to membrane				breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|urinary_tract(1)	5		Ovarian(80;0.0694)				tgctgctggcgctgctgctgctg	0.724													7	103	---	---	---	---					
MAP3K15	389840	broad.mit.edu	37	X	19416433	19416433	+	Frame_Shift_Del	DEL	C	C	-			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:19416433delC	ENST00000338883.4	-	15	1976	c.1977delG	c.(1975-1977)ggfs	p.G659fs	MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000469203.2_Frame_Shift_Del_p.G491fs|MAP3K15_ENST00000359173.3_Frame_Shift_Del_p.G94fs	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	659	Protein kinase.						ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					ACGTGCCTTTCCCCAAGACAA	0.463													29	202	---	---	---	---					
MAGEA10	4109	broad.mit.edu	37	X	151303851	151303851	+	Frame_Shift_Del	DEL	G	G	-			TCGA-P3-A6T5-01A-11D-A34J-08	TCGA-P3-A6T5-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	66fbf537-8f7d-496c-9532-da3794671124	96e888d8-e882-4837-b411-0cd785fe2408	g.chrX:151303851delG	ENST00000370323.4	-	4	558	c.242delC	c.(241-243)cafs	p.P81fs	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Frame_Shift_Del_p.P81fs	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	81										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GGGAGGATTTGGTGTCTCATC	0.537													29	187	---	---	---	---					
