Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	ACHILLES_Lineage_Results_Top_Genes	CGC_CancerGermlineMut	CGC_CancerMolecularGenetics	CGC_CancerSomaticMut	CGC_CancerSyndrome	CGC_Chr	CGC_ChrBand	CGC_GeneID	CGC_Name	CGC_OtherGermlineMut	CGC_TissueType	COSMIC_n_overlapping_mutations	COSMIC_overlapping_mutation_descriptions	ClinVar_ASSEMBLY	ClinVar_HGMD_ID	ClinVar_SYM	ClinVar_TYPE	ClinVar_rs	Ensembl_so_accession	Ensembl_so_term	Familial_Cancer_Genes_Reference	Familial_Cancer_Genes_Synonym	annotation_transcript	bcgsc	broad	build	ccds_id	dbNSFP_1000Gp1_AC	dbNSFP_1000Gp1_AF	dbNSFP_1000Gp1_AFR_AC	dbNSFP_1000Gp1_AFR_AF	dbNSFP_1000Gp1_AMR_AC	dbNSFP_1000Gp1_AMR_AF	dbNSFP_1000Gp1_ASN_AC	dbNSFP_1000Gp1_ASN_AF	dbNSFP_1000Gp1_EUR_AC	dbNSFP_1000Gp1_EUR_AF	dbNSFP_Ancestral_allele	dbNSFP_CADD_phred	dbNSFP_CADD_raw	dbNSFP_CADD_raw_rankscore	dbNSFP_ESP6500_AA_AF	dbNSFP_ESP6500_EA_AF	dbNSFP_Ensembl_geneid	dbNSFP_Ensembl_transcriptid	dbNSFP_FATHMM_pred	dbNSFP_FATHMM_rankscore	dbNSFP_FATHMM_score	dbNSFP_GERP_NR	dbNSFP_GERP_RS	dbNSFP_GERP_RS_rankscore	dbNSFP_Interpro_domain	dbNSFP_LRT_Omega	dbNSFP_LRT_converted_rankscore	dbNSFP_LRT_pred	dbNSFP_LRT_score	dbNSFP_LR_pred	dbNSFP_LR_rankscore	dbNSFP_LR_score	dbNSFP_MutationAssessor_pred	dbNSFP_MutationAssessor_rankscore	dbNSFP_MutationAssessor_score	dbNSFP_MutationTaster_converted_rankscore	dbNSFP_MutationTaster_pred	dbNSFP_MutationTaster_score	dbNSFP_Polyphen2_HDIV_pred	dbNSFP_Polyphen2_HDIV_rankscore	dbNSFP_Polyphen2_HDIV_score	dbNSFP_Polyphen2_HVAR_pred	dbNSFP_Polyphen2_HVAR_rankscore	dbNSFP_Polyphen2_HVAR_score	dbNSFP_RadialSVM_pred	dbNSFP_RadialSVM_rankscore	dbNSFP_RadialSVM_score	dbNSFP_Reliability_index	dbNSFP_SIFT_converted_rankscore	dbNSFP_SIFT_pred	dbNSFP_SIFT_score	dbNSFP_SLR_test_statistic	dbNSFP_SiPhy_29way_logOdds	dbNSFP_SiPhy_29way_logOdds_rankscore	dbNSFP_SiPhy_29way_pi	dbNSFP_UniSNP_ids	dbNSFP_Uniprot_aapos	dbNSFP_Uniprot_acc	dbNSFP_Uniprot_id	dbNSFP_aaalt	dbNSFP_aapos	dbNSFP_aapos_FATHMM	dbNSFP_aapos_SIFT	dbNSFP_aaref	dbNSFP_cds_strand	dbNSFP_codonpos	dbNSFP_folddegenerate	dbNSFP_genename	dbNSFP_hg18_pos1coor	dbNSFP_phastCons100way_vertebrate	dbNSFP_phastCons100way_vertebrate_rankscore	dbNSFP_phastCons46way_placental	dbNSFP_phastCons46way_placental_rankscore	dbNSFP_phastCons46way_primate	dbNSFP_phastCons46way_primate_rankscore	dbNSFP_phyloP100way_vertebrate	dbNSFP_phyloP100way_vertebrate_rankscore	dbNSFP_phyloP46way_placental	dbNSFP_phyloP46way_placental_rankscore	dbNSFP_phyloP46way_primate	dbNSFP_phyloP46way_primate_rankscore	dbNSFP_refcodon	entrez_gene_id	external_id_capture	gencode_transcript_name	gencode_transcript_status	gencode_transcript_tags	gencode_transcript_type	gene_type	havana_transcript	hgsc	igv_bad	ucsc	t_alt_count	t_ref_count	n_alt_count	n_ref_count	validation_judgement_rna	validation_power_rna	validation_tumor_alt_count_rna	validation_tumor_ref_count_rna	validation_normal_alt_count_rna	validation_normal_ref_count_rna	min_val_count_rna	validation_judgement_targeted	validation_power_targeted	validation_tumor_alt_count_targeted	validation_tumor_ref_count_targeted	validation_normal_alt_count_targeted	validation_normal_ref_count_targeted	min_val_count_targeted	validation_judgement_localAssembly	validation_power_localAssembly	t_alt_count_localAssembly	t_ref_count_localAssembly	n_alt_count_localAssembly	n_ref_count_localAssembly	min_val_count_localAssembly	validation_judgement_KRAS	validation_power_KRAS	t_alt_count_KRAS	t_ref_count_KRAS	n_alt_count_KRAS	n_ref_count_KRAS	min_val_count_KRAS	pon_loglike	pon_pass_loglike	localAssembly_detected	ExAC_AN	ExAC_AC	ExAC_LQ	passExAC	SCNA_NA	SCNA_NB	SCNA_q_hat	SCNA_tau	IS_SCNA	purity	ploidy	dna_fraction_in_tumor	CCF_hat	CCF_CI95_low	CCF_CI95_high	CCF_mode	CCF_mean	CCF_median	clonal	CCF_CI_low	CCF_CI_high
TAF4	6874	broad.mit.edu	37	20	60587922	60587923	+	Frame_Shift_Ins	INS	-	-	GCCT			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr20:60587922_60587923insGCCT	ENST00000252996.4	-	3	1588_1589	c.1589_1590insAGGC	c.(1588-1590)gccfs	p.-530fs	TAF4_ENST00000609045.1_5'UTR	NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa			37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)		CCGTTGTCTGGGCCTGAGACAC	0.589000																								0							SO:0001589	frameshift_variant			ENST00000252996.4	0	1	hg19	CCDS33500.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	TAF4-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000079968.2	1	0	0	64	553	0	111	0	2.429332e-01	0	9	0	111	2	0	0	0	0	0	0		1	1.000000	80	548	0	104	2								-3.017764	1	1	0	0		1	2	2	4	2.038962	0	0.240000	3.570000	0.375000	0.990000	0.820000	1.000000	1.000000	0.977506	0.990000	1	9.300000e-01	1
ABCC2	1244	broad.mit.edu	37	10	101594176	101594176	+	Missense_Mutation	SNP	C	C	T	rs142715085	byFrequency	TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr10:101594176C>T	ENST00000370449.4	+	24	3411	c.3298C>T	c.(3298-3300)Cgc>Tgc	p.R1100C		NM_000392.3	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	p.R1100C(1)		67		Colorectal(252;0.234)		Adenosine triphosphate(DB00171)|Aminohippurate(DB00345)|Arsenic trioxide(DB01169)|Atorvastatin(DB01076)|Canagliflozin(DB08907)|Carbamazepine(DB00564)|Carboplatin(DB00958)|Cisplatin(DB00515)|Clotrimazole(DB00257)|Conjugated Estrogens(DB00286)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dexamethasone(DB01234)|Docetaxel(DB01248)|Doxorubicin(DB00997)|Eprosartan(DB00876)|Ethinyl Estradiol(DB00977)|Etoposide(DB00773)|Ezetimibe(DB00973)|Furosemide(DB00695)|Fusidic Acid(DB02703)|Gadoxetate(DB08884)|Glutathione(DB00143)|Glyburide(DB01016)|Indinavir(DB00224)|Indomethacin(DB00328)|Irinotecan(DB00762)|Ivermectin(DB00602)|Lamivudine(DB00709)|Leucovorin(DB00650)|Levetiracetam(DB01202)|Lomefloxacin(DB00978)|Lovastatin(DB00227)|Methotrexate(DB00563)|Mycophenolate mofetil(DB00688)|Nifedipine(DB01115)|Norgestimate(DB00957)|Ofloxacin(DB01165)|Olmesartan(DB00275)|Oxaliplatin(DB00526)|Paclitaxel(DB01229)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Pitavastatin(DB08860)|Pranlukast(DB01411)|Pravastatin(DB00175)|Probenecid(DB01032)|Quinidine(DB00908)|Reserpine(DB00206)|Rifampicin(DB01045)|Ritonavir(DB00503)|Saquinavir(DB01232)|Simvastatin(DB00641)|Sorafenib(DB00398)|Sparfloxacin(DB01208)|Spironolactone(DB00421)|Sulfasalazine(DB00795)|Sulfinpyrazone(DB01138)|Sunitinib(DB01268)|Tamoxifen(DB00675)|Telmisartan(DB00966)|Tenofovir(DB00300)|Tetrahydrofolic acid(DB00116)|Ursodeoxycholic acid(DB01586)|Vasopressin(DB00067)|Verapamil(DB00661)|Vinblastine(DB00570)|Vincristine(DB00541)	TCAGTCCTTGCGCAGCTGGAT	0.468000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000370449.4	0	1	hg19	CCDS7484.1	.	.	.	.	.	.	.	.	.	.	C	16.21	3.058211	0.55325	0.0	8.14E-4	ENSG00000023839	ENST00000370449	D	0.89681	-2.55	5.28	4.38	0.52667	ABC transporter, transmembrane domain, type 1 (1);ABC transporter, integral membrane type 1 (1);ABC transporter, transmembrane domain (1);	0.000000	0.85682	D	0.000000	D	0.95468	0.8528	M	0.92122	3.275	0.80722	D	1	D	0.89917	1.0	D	0.97110	1.0	D	0.96170	0.9122	10	0.87932	D	0	-10.2227	13.8333	0.63393	0.0:0.9261:0.0:0.0739	.	1100	Q92887	MRP2_HUMAN	C	1100	ENSP00000359478:R1100C	ENSP00000359478:R1100C	R	+	1	0	ABCC2	101584166	1.000000	0.71417	0.852000	0.33557	0.053000	0.15095	4.409000	0.59768	1.228000	0.43614	0.511000	0.50034	CGC		TCGA-2J-AABO-01A-21D-A40W-08	ABCC2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000049825.1	1	0	0	41	333	0	92	0	0	0	1	0	92	2		0	0	0	0	0	2	1	1.000000	41	330	0	89	2								-8.493167	1	1	121412	61	52	1	1	2	3	1.889254	1	0.240000	3.570000	0.321429	0.990000	0.750000	1.000000	1.000000	0.957008	0.990000	1	8.800000e-01	1
SEMA4G	57715	broad.mit.edu	37	10	102743445	102743445	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr10:102743445G>A	ENST00000370250.4	+	14	2447	c.2074G>A	c.(2074-2076)Gcc>Acc	p.A692T	MRPL43_ENST00000299179.5_Intron|MRPL43_ENST00000318325.2_Intron|MRPL43_ENST00000493646.1_5'Flank|MRPL43_ENST00000370241.3_Intron|MRPL43_ENST00000342071.1_Intron|MRPL43_ENST00000370242.4_Intron|RP11-108L7.4_ENST00000447344.1_RNA|SEMA4G_ENST00000517724.1_Intron|SEMA4G_ENST00000210633.3_Missense_Mutation_p.A697T	NM_017893.3	NP_060363.2	Q9NTN9	SEM4G_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G			25		Colorectal(252;0.234)			CCTCATCCTGGCCTCCTCCCT	0.642000																								0							SO:0001583	missense			ENST00000370250.4	1	1	hg19		.	.	.	.	.	.	.	.	.	.	g	8.197	0.797197	0.16327	.	.	ENSG00000095539	ENST00000370250;ENST00000210633	T;T	0.17054	2.3;2.37	5.53	5.53	0.82687	.	0.842932	0.11009	N	0.609640	T	0.07818	0.0196	N	0.04880	-0.145	0.30368	N	0.783125	B	0.25667	0.131	B	0.16289	0.015	T	0.16808	-1.0390	10	0.13108	T	0.6	.	8.7621	0.34680	0.0779:0.0:0.7717:0.1503	.	697	Q9NTN9-2	.	T	692;697	ENSP00000359270:A692T;ENSP00000210633:A697T	ENSP00000210633:A697T	A	+	1	0	SEMA4G	102733435	1.000000	0.71417	1.000000	0.80357	0.987000	0.75469	4.420000	0.59841	2.613000	0.88420	0.550000	0.68814	GCC		TCGA-2J-AABO-01A-21D-A40W-08	SEMA4G-002	KNOWN	basic	protein_coding	protein_coding	OTTHUMT00000049920.2	1	0	1	13	68	0	21	1	8.044379e-01	7	11	0	21	2		0	0	0	0	0	2	1	0.999628	13	66	0	20	2								-19.999370	1	1	0	0		1	1	2	3	1.889254	1	0.240000	3.570000	0.321429	0.990000	0.870000	1.000000	1.000000	0.992608	0.990000	1	9.900000e-01	1
ADARB2	105	broad.mit.edu	37	10	1406022	1406022	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr10:1406022G>A	ENST00000381312.1	-	3	603	c.278C>T	c.(277-279)gCg>gTg	p.A93V	RP11-398B16.2_ENST00000432987.1_RNA	NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)			41		all_epithelial(10;0.059)|Colorectal(49;0.0815)			cgcgccgggcgcgccgccccg	0.726000																								0							SO:0001583	missense			ENST00000381312.1	1	1	hg19	CCDS7058.1	.	.	.	.	.	.	.	.	.	.	g	5.998	0.367978	0.11352	0.0	1.2E-4	ENSG00000185736	ENST00000381312	T	0.24350	1.86	4.69	2.84	0.33178	.	1.304660	0.04734	N	0.421667	T	0.19886	0.0478	N	0.19112	0.55	0.25308	N	0.989223	B	0.15141	0.012	B	0.09377	0.004	T	0.29640	-1.0005	10	0.38643	T	0.18	-0.0474	10.0945	0.42466	0.0756:0.1376:0.7868:0.0	.	93	Q9NS39	RED2_HUMAN	V	93	ENSP00000370713:A93V	ENSP00000370713:A93V	A	-	2	0	ADARB2	1396022	0.004000	0.15560	0.000000	0.03702	0.000000	0.00434	1.487000	0.35540	0.418000	0.25898	-0.375000	0.07067	GCG		TCGA-2J-AABO-01A-21D-A40W-08	ADARB2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000046426.1	1	0	0	13	43	0	13		0	0	0	0	13	2		0	0	0	0	0	2	1	0.999385	12	37	0	12	2								-20.000000	1	1	115080	1	21	1	1	2	3	1.893925	1	0.240000	3.570000	0.321429	0.990000	0.990000	1.000000	1.000000	0.999689	0.990000	1	9.900000e-01	1
TAF3	83860	broad.mit.edu	37	10	8006929	8006929	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr10:8006929C>T	ENST00000344293.5	+	3	1662	c.1456C>T	c.(1456-1458)Ccc>Tcc	p.P486S		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa			40					TTCAAATATGCCCCCCAACTT	0.488000																								0							SO:0001583	missense			ENST00000344293.5	0	1	hg19	CCDS41487.1	.	.	.	.	.	.	.	.	.	.	C	13.39	2.223998	0.39300	.	.	ENSG00000165632	ENST00000344293	T	0.34859	1.34	5.62	4.72	0.59763	.	0.000000	0.64402	D	0.000003	T	0.53594	0.1806	M	0.80183	2.485	0.80722	D	1	D	0.56746	0.977	P	0.54460	0.753	T	0.56836	-0.7913	10	0.33940	T	0.23	-14.7526	14.6258	0.68621	0.0:0.93:0.0:0.07	.	486	Q5VWG9	TAF3_HUMAN	S	486	ENSP00000340271:P486S	ENSP00000340271:P486S	P	+	1	0	TAF3	8046935	1.000000	0.71417	0.983000	0.44433	0.035000	0.12851	4.211000	0.58507	1.389000	0.46526	0.650000	0.86243	CCC		TCGA-2J-AABO-01A-21D-A40W-08	TAF3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000046725.1	0	0	0	6	622	0	109	0	1.308925e-02	0	15	0	109	2		0	0	0	0	0	2	1	0.964932	6	621	0	107	2								-1.763907	0	1	0	0		1	1	2	3	1.893925	1	0.240000	3.570000	0.321429	0.090000	0.030000	0.190000	0.090000	0.103379	0.090000	0	5.000000e-02	1.400000e-01
ABCG4	64137	broad.mit.edu	37	11	119030980	119030980	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr11:119030980C>T	ENST00000449422.2	+	13	1669	c.1481C>T	c.(1480-1482)aCg>aTg	p.T494M	ABCG4_ENST00000307417.3_Missense_Mutation_p.T494M|ABCG4_ENST00000531739.1_Missense_Mutation_p.T494M	NM_001142505.1	NP_001135977.1	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	p.T494M(1)		44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)			TACTGGATGACGGGCCAGCCC	0.647000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000449422.2	1	1	hg19	CCDS8415.1	.	.	.	.	.	.	.	.	.	.	C	33	5.223466	0.95139	2.27E-4	0.0	ENSG00000172350	ENST00000307417;ENST00000449422;ENST00000531739	T;T;T	0.73047	-0.71;-0.71;-0.71	5.2	5.2	0.72013	ABC-2 type transporter (1);	0.000000	0.85682	D	0.000000	D	0.85452	0.5700	M	0.80982	2.52	0.80722	D	1	D	0.89917	1.0	D	0.87578	0.998	D	0.86992	0.2111	10	0.87932	D	0	-9.1283	18.9923	0.92798	0.0:1.0:0.0:0.0	.	494	Q9H172	ABCG4_HUMAN	M	494	ENSP00000304111:T494M;ENSP00000406874:T494M;ENSP00000434318:T494M	ENSP00000304111:T494M	T	+	2	0	ABCG4	118536190	1.000000	0.71417	0.995000	0.50966	0.987000	0.75469	7.629000	0.83207	2.720000	0.93068	0.558000	0.71614	ACG		TCGA-2J-AABO-01A-21D-A40W-08	ABCG4-002	PUTATIVE	alternative_5_UTR|basic|appris_principal|exp_conf|CCDS	protein_coding	protein_coding	OTTHUMT00000388215.1	1	0	1	89	321	0	78		0	0	0	0	78	2		0	0	0	0	0	2	1	1.000000	89	316	0	74	2								-3.879414	1	1	121412	6	41	1	2	2	4	2.072671	0	0.240000	3.570000	0.385908	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
CBL	867	broad.mit.edu	37	11	119144654	119144654	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr11:119144654G>C	ENST00000264033.4	+	4	1043	c.667G>C	c.(667-669)Gct>Cct	p.A223P		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase			251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)			GGAGGCCATGGCTCTGAAATC	0.473000			T, Mis S, O	MLL	AML, JMML, MDS				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies						Dom, Rec	yes		11	11q23.3	867	Cas-Br-M (murine) ecotropic retroviral transforming		L	0							SO:0001583	missense	Familial Cancer Database	Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CBL-associated JMML	ENST00000264033.4	1	1	hg19	CCDS8418.1	.	.	.	.	.	.	.	.	.	.	G	22.8	4.337068	0.81801	.	.	ENSG00000110395	ENST00000264033	D	0.83250	-1.7	5.48	5.48	0.80851	Adaptor protein Cbl, PTB domain (1);EF-hand-like domain (1);Adaptor protein Cbl, EF hand-like (1);	0.000000	0.85682	D	0.000000	D	0.92583	0.7644	M	0.86740	2.835	0.80722	D	1	D	0.89917	1.0	D	0.87578	0.998	D	0.93244	0.6629	10	0.66056	D	0.02	-36.3416	19.3601	0.94434	0.0:0.0:1.0:0.0	.	223	P22681	CBL_HUMAN	P	223	ENSP00000264033:A223P	ENSP00000264033:A223P	A	+	1	0	CBL	118649864	1.000000	0.71417	1.000000	0.80357	0.996000	0.88848	9.852000	0.99516	2.593000	0.87608	0.491000	0.48974	GCT		TCGA-2J-AABO-01A-21D-A40W-08	CBL-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000388219.4	1	0	1	34	298	0	64	0	1.126106e-02	0	2	0	64	2		0	0	0	0	0	2	1	1.000000	34	294	0	64	2								-12.791490	1	1	0	0		1	2	2	4	2.072671	0	0.240000	3.570000	0.385908	0.990000	0.750000	1.000000	1.000000	0.963851	0.990000	1	8.900000e-01	1
CD44	960	broad.mit.edu	37	11	35218362	35218362	+	Nonsense_Mutation	SNP	C	C	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr11:35218362C>A	ENST00000428726.2	+	6	860	c.737C>A	c.(736-738)tCa>tAa	p.S246*	CD44_ENST00000433354.2_Nonsense_Mutation_p.S246*|CD44_ENST00000526669.2_Intron|CD44_ENST00000360158.4_Intron|CD44_ENST00000352818.4_Intron|CD44_ENST00000449691.2_Nonsense_Mutation_p.S246*|CD44_ENST00000434472.2_Intron|CD44_ENST00000437706.2_Nonsense_Mutation_p.S246*|CD44_ENST00000263398.6_Intron|CD44_ENST00000415148.2_Intron|CD44_ENST00000433892.2_Intron|CD44_ENST00000278386.6_Intron	NM_000610.3	NP_000601.3	P16070	CD44_HUMAN	CD44 molecule (Indian blood group)			23	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)	Hyaluronan(DB08818)	GATTGGTTTTCATGGTTGTTT	0.383000																								0							SO:0001587	stop_gained			ENST00000428726.2	0	1	hg19	CCDS7897.1	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	C|C	21.7|21.7	4.188320|4.188320	0.78789|0.78789	.|.	.|.	ENSG00000026508|ENSG00000026508	ENST00000525685|ENST00000433354;ENST00000449691;ENST00000437706;ENST00000428726	.|.	.|.	.|.	4.74|4.74	2.86|2.86	0.33363|0.33363	.|.	.|0.325033	.|0.22362	.|N	.|0.061071	T|.	0.30510|.	0.0767|.	.|.	.|.	.|.	0.80722|0.80722	D|D	1|1	.|.	.|.	.|.	.|.	.|.	.|.	T|.	0.08411|.	-1.0723|.	4|.	.|0.05959	.|T	.|0.93	-0.231|-0.231	7.7276|7.7276	0.28769|0.28769	0.0:0.8031:0.0:0.1969|0.0:0.8031:0.0:0.1969	.|.	.|.	.|.	.|.	N|X	114|246	.|.	.|ENSP00000398632:S246X	H|S	+|+	1|2	0|0	CD44|CD44	35174938|35174938	1.000000|1.000000	0.71417|0.71417	0.982000|0.982000	0.44146|0.44146	0.137000|0.137000	0.21094|0.21094	2.006000|2.006000	0.40874|0.40874	0.518000|0.518000	0.28383|0.28383	0.655000|0.655000	0.94253|0.94253	CAT|TCA		TCGA-2J-AABO-01A-21D-A40W-08	CD44-001	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000388927.1	0	0	0	5	276	0	48	0	3.019456e-03	0	4	0	48	2		0	0	0	0	0	2	1	0.936318	5	273	0	48	2								-6.154872	1	1	0	0		1	2	2	4	2.072671	0	0.240000	3.570000	0.385908	0.200000	0.070000	0.420000	0.200000	0.217427	0.200000	0	1.200000e-01	3.000000e-01
RAG1	5896	broad.mit.edu	37	11	36597180	36597180	+	Missense_Mutation	SNP	C	C	T	rs121918572		TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr11:36597180C>T	ENST00000299440.5	+	2	2438	c.2326C>T	c.(2326-2328)Cgg>Tgg	p.R776W		NM_000448.2	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	p.R776R(1)		65	all_lung(20;0.226)	all_hematologic(20;0.107)			GGAAGAACTGCGGGATCGGGT	0.483000									Familial Hemophagocytic Lymphohistiocytosis				Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)											1	Substitution - coding silent(1)	GRCh37	CM090373	RAG1	M	rs121918572	SO:0001583	missense	Familial Cancer Database	FHLH, FHL, Familial Hemophagocytic Reticulosis, FHR	ENST00000299440.5	1	1	hg19	CCDS7902.1	.	.	.	.	.	.	.	.	.	.	C	16.34	3.095241	0.56075	.	.	ENSG00000166349	ENST00000534663;ENST00000299440	D;D	0.88046	-2.33;-2.33	6.13	-0.167	0.13347	.	0.000000	0.85682	D	0.000000	D	0.95345	0.8489	H	0.96333	3.805	0.80722	D	1	D	0.89917	1.0	D	0.87578	0.998	D	0.96683	0.9505	10	0.87932	D	0	.	18.3544	0.90352	0.5232:0.4768:0.0:0.0	.	776	P15918	RAG1_HUMAN	W	776	ENSP00000434610:R776W;ENSP00000299440:R776W	ENSP00000299440:R776W	R	+	1	2	RAG1	36553756	0.995000	0.38212	0.906000	0.35671	0.895000	0.52256	0.749000	0.26320	0.086000	0.17137	0.644000	0.83932	CGG		TCGA-2J-AABO-01A-21D-A40W-08	RAG1-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000389535.1	1	0	0	42	382	0	75	0	0	0	1	0	75	2		0	0	0	0	0	2	1	1.000000	42	378	0	73	2								-13.737970	1	1	0	0		1	2	2	4	2.072671	0	0.240000	3.570000	0.385908	0.990000	0.750000	1.000000	1.000000	0.957324	0.990000	1	8.800000e-01	1
OR5M1	390168	broad.mit.edu	37	11	56380401	56380401	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr11:56380401C>T	ENST00000526538.1	-	1	577	c.578G>A	c.(577-579)cGt>cAt	p.R193H		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1			12					CTTTTTGACACGGGTGTCAGA	0.433000																								0							SO:0001583	missense			ENST00000526538.1	1	1	hg19	CCDS53631.1	.	.	.	.	.	.	.	.	.	.	C	0	-2.616311	0.00120	.	.	ENSG00000255012	ENST00000526538	T	0.00076	8.76	3.71	-2.03	0.07365	GPCR, rhodopsin-like superfamily (1);	.	.	.	.	T	0.00039	0.0001	N	0.01742	-0.745	0.09310	N	1	B	0.02656	0.0	B	0.06405	0.002	T	0.14337	-1.0476	9	0.02654	T	1	-10.5846	7.7176	0.28712	0.0:0.179:0.546:0.2751	.	193	Q8NGP8	OR5M1_HUMAN	H	193	ENSP00000435416:R193H	ENSP00000435416:R193H	R	-	2	0	OR5M1	56136977	0.000000	0.05858	0.020000	0.16555	0.104000	0.19210	-1.808000	0.01732	-0.719000	0.04942	-1.820000	0.00599	CGT		TCGA-2J-AABO-01A-21D-A40W-08	OR5M1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000391610.1	1	0	0	62	230	0	37		0	0	0	0	37	2		0	0	0	0	0	2	1	1.000000	58	215	0	55	2								-20.000000	1	1	120828	2	33	1	2	2	4	2.072671	0	0.240000	3.570000	0.385908	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
TNKS1BP1	85456	broad.mit.edu	37	11	57076887	57076887	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr11:57076887C>T	ENST00000532437.1	-	5	3609	c.3298G>A	c.(3298-3300)Gca>Aca	p.A1100T	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.A1100T|TNKS1BP1_ENST00000530920.1_5'Flank			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa			64		all_epithelial(135;0.21)			CTAAATGCTGCCTCTCGCTGG	0.607000																								0							SO:0001583	missense			ENST00000532437.1	1	1	hg19	CCDS7951.1	.	.	.	.	.	.	.	.	.	.	C	8.741	0.918881	0.17982	.	.	ENSG00000149115	ENST00000358252;ENST00000532437	T;T	0.31769	1.48;1.48	5.05	-0.935	0.10423	.	1.600840	0.03626	N	0.237178	T	0.24044	0.0582	L	0.44542	1.39	0.09310	N	1	B	0.23937	0.094	B	0.23419	0.046	T	0.15009	-1.0452	10	0.26408	T	0.33	0.0635	3.3819	0.07257	0.1927:0.3151:0.0:0.4922	.	1100	Q9C0C2	TB182_HUMAN	T	1100	ENSP00000350990:A1100T;ENSP00000437271:A1100T	ENSP00000350990:A1100T	A	-	1	0	TNKS1BP1	56833463	0.000000	0.05858	0.005000	0.12908	0.056000	0.15407	-1.427000	0.02441	-0.048000	0.13401	-0.379000	0.06801	GCA		TCGA-2J-AABO-01A-21D-A40W-08	TNKS1BP1-003	KNOWN	alternative_5_UTR|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000392455.1	1	0	1	30	326	0	60	1	9.999795e-01	25	158	0	60	2		0	0	0	0	0	2	1	1.000000	30	326	0	57	2								-20.000000	1	1	0	0		1	2	2	4	2.072671	0	0.240000	3.570000	0.385908	0.870000	0.600000	1.000000	1.000000	0.866442	0.870000	1	7.300000e-01	1
IRF7	3665	broad.mit.edu	37	11	613572	613572	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr11:613572C>T	ENST00000397574.2	-	9	1240	c.871G>A	c.(871-873)Gtg>Atg	p.V291M	IRF7_ENST00000525445.1_Missense_Mutation_p.V185M|IRF7_ENST00000397570.1_Missense_Mutation_p.V262M|IRF7_ENST00000397562.3_De_novo_Start_InFrame|IRF7_ENST00000348655.6_Missense_Mutation_p.V262M|IRF7_ENST00000397566.1_Missense_Mutation_p.V304M|IRF7_ENST00000330243.5_Missense_Mutation_p.V304M	NM_001572.3	NP_001563.2	Q92985	IRF7_HUMAN	interferon regulatory factor 7			8		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)			ATGATGGTCACGTCCAGCGCC	0.682000																								0							SO:0001583	missense			ENST00000397574.2	0	1	hg19	CCDS7703.1	.	.	.	.	.	.	.	.	.	.	C	14.29	2.491677	0.44249	.	.	ENSG00000185507	ENST00000525445;ENST00000348655;ENST00000397570;ENST00000397566;ENST00000397574;ENST00000330243	D;D;D;D;D;D	0.96619	-4.07;-4.07;-4.07;-4.07;-4.07;-4.07	4.0	3.06	0.35304	SMAD domain-like (1);SMAD/FHA domain (1);Interferon regulatory factor-3 (1);	0.599107	0.16746	N	0.201252	D	0.96513	0.8862	L	0.50333	1.59	0.80722	D	1	D;D;D;D	0.89917	1.0;0.991;0.997;0.997	D;P;P;P	0.71870	0.975;0.78;0.835;0.847	D	0.95215	0.8329	10	0.87932	D	0	-22.3084	7.8587	0.29497	0.1718:0.738:0.0:0.0902	.	185;262;291;304	E9PSE3;Q92985-2;Q92985;Q92985-4	.;.;IRF7_HUMAN;.	M	185;262;262;304;291;304	ENSP00000434009:V185M;ENSP00000331803:V262M;ENSP00000380700:V262M;ENSP00000380697:V304M;ENSP00000380704:V291M;ENSP00000329411:V304M	ENSP00000329411:V304M	V	-	1	0	IRF7	603572	0.009000	0.17119	0.994000	0.49952	0.212000	0.24457	-0.038000	0.12144	0.984000	0.38629	0.491000	0.48974	GTG		TCGA-2J-AABO-01A-21D-A40W-08	IRF7-002	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000255026.1	0	0	0	9	155	0	24	1	9.228944e-01	8	72	0	24	2		0	0	0	0	0	2	1	0.994147	9	152	0	24	2								-12.838720	1	1	0	0		1	2	7	9	3.118716	1	0.240000	3.570000	0.586957	0.880000	0.430000	1.000000	1.000000	0.840073	0.880000	1	6.300000e-01	1
HRASLS5	117245	broad.mit.edu	37	11	63233706	63233706	+	Missense_Mutation	SNP	G	G	A	rs80217781	by1000genomes	TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr11:63233706G>A	ENST00000301790.4	-	5	782	c.623C>T	c.(622-624)cCg>cTg	p.P208L	HRASLS5_ENST00000540857.1_Missense_Mutation_p.P198L|HRASLS5_ENST00000539221.1_Missense_Mutation_p.P208L			Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5			14					CTTGTCCACCGGCAAGGGCAG	0.512000																								0							SO:0001583	missense			ENST00000301790.4	1	1	hg19	CCDS8044.1	1	4.578754578754579E-4	0	0.0	0	0.0	1	0.0017482517482517483	0	0.0	G	16.40	3.113436	0.56398	.	.	ENSG00000168004	ENST00000540857;ENST00000539221;ENST00000301790	T;T;T	0.23552	1.9;1.9;1.9	4.16	4.16	0.48862	NC (1);	0.211175	0.39083	N	0.001474	T	0.51787	0.1695	M	0.82433	2.59	0.58432	D	0.999999	D;D;D	0.89917	1.0;1.0;1.0	D;D;D	0.91635	0.999;0.995;0.997	T	0.55405	-0.8146	10	0.59425	D	0.04	-17.8362	12.2645	0.54670	0.0:0.0:1.0:0.0	.	208;198;208	F5GZ87;F5H4Y9;Q96KN8	.;.;HRSL5_HUMAN	L	198;208;208	ENSP00000444809:P198L;ENSP00000443873:P208L;ENSP00000301790:P208L	ENSP00000301790:P208L	P	-	2	0	HRASLS5	62990282	1.000000	0.71417	0.966000	0.40874	0.106000	0.19336	4.885000	0.63142	2.618000	0.88619	0.650000	0.86243	CCG		TCGA-2J-AABO-01A-21D-A40W-08	HRASLS5-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000396375.1	1	0	0	22	332	0	78	0	1.242332e-02	0	3	0	78	2		0	0	0	0	0	2	1	0.999999	22	330	0	77	2								-2.690179	1	1	121412	6	40	1	2	2	4	2.072671	0	0.240000	3.570000	0.385908	0.650000	0.410000	0.950000	0.640000	0.662595	0.650000	0	5.200000e-01	8.000000e-01
NLRP14	338323	broad.mit.edu	37	11	7081264	7081264	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr11:7081264C>T	ENST00000299481.4	+	9	3119	c.2773C>T	c.(2773-2775)Cgg>Tgg	p.R925W		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14			21					TGATGTCTTTCGGCATCCAAG	0.428000																								0							SO:0001583	missense			ENST00000299481.4	0	1	hg19	CCDS7776.1	.	.	.	.	.	.	.	.	.	.	C	11.86	1.764218	0.31228	.	.	ENSG00000158077	ENST00000299481	T	0.48522	0.81	4.5	0.00652	0.14067	.	0.764957	0.10829	N	0.629577	T	0.40979	0.1139	M	0.74546	2.27	0.09310	N	1	B	0.24721	0.11	B	0.12837	0.008	T	0.46317	-0.9200	10	0.72032	D	0.01	.	2.1725	0.03853	0.3529:0.3743:0.1721:0.1007	.	925	Q86W24	NAL14_HUMAN	W	925	ENSP00000299481:R925W	ENSP00000299481:R925W	R	+	1	2	NLRP14	7037840	0.000000	0.05858	0.002000	0.10522	0.987000	0.75469	-0.266000	0.08631	0.204000	0.20548	0.655000	0.94253	CGG		TCGA-2J-AABO-01A-21D-A40W-08	NLRP14-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000384551.1	0	0	0	6	831	0	137		0	0	0	0	137	2		0	0	0	0	0	2	1	0.963576	6	821	0	131	2								-2.130933	0	1	121412	4	39	1	2	2	4	2.072671	0	0.240000	3.570000	0.385908	0.070000	0.010000	0.170000	0.080000	0.085504	0.070000	0	4.000000e-02	1.200000e-01
FAT3	120114	broad.mit.edu	37	11	92600211	92600211	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr11:92600211C>T	ENST00000298047.6	+	21	11980	c.11963C>T	c.(11962-11964)tCg>tTg	p.S3988L	FAT3_ENST00000525166.1_Missense_Mutation_p.S3838L|FAT3_ENST00000533797.1_Missense_Mutation_p.S323L|FAT3_ENST00000409404.2_Missense_Mutation_p.S3988L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	p.S3988L(2)|p.S563L(1)		85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)			TGCCTGGACTCGGTGATACTG	0.617000										TCGA Ovarian(4;0.039)														3	Substitution - Missense(3)						SO:0001583	missense			ENST00000298047.6	1	1	hg19		.	.	.	.	.	.	.	.	.	.	C	22.8	4.334571	0.81801	.	.	ENSG00000165323	ENST00000298047;ENST00000409404;ENST00000525166;ENST00000533797	T;T;T;T	0.69926	-0.44;-0.44;-0.44;-0.44	5.94	5.94	0.96194	Concanavalin A-like lectin/glucanase (1);Concanavalin A-like lectin/glucanase, subgroup (1);Laminin G domain (2);Laminin G, subdomain 2 (1);	.	.	.	.	D	0.82476	0.5045	M	0.72894	2.215	0.80722	D	1	D;D	0.89917	1.0;0.957	D;P	0.87578	0.998;0.781	T	0.82220	-0.0565	9	0.62326	D	0.03	.	20.3633	0.98874	0.0:1.0:0.0:0.0	.	3988;3988	Q8TDW7-3;Q8TDW7	.;FAT3_HUMAN	L	3988;3988;3838;323	ENSP00000298047:S3988L;ENSP00000387040:S3988L;ENSP00000432586:S3838L;ENSP00000436399:S323L	ENSP00000298047:S3988L	S	+	2	0	FAT3	92239859	1.000000	0.71417	0.980000	0.43619	0.553000	0.35397	5.694000	0.68272	2.826000	0.97356	0.561000	0.74099	TCG		TCGA-2J-AABO-01A-21D-A40W-08	FAT3-201	KNOWN	basic	protein_coding	protein_coding		1	0	1	7	39	0	24		0	0	0	0	24	2		0	0	0	0	0	2	1	0.982143	7	38	0	24	2								-14.536770	1	1	120146	1	31	1	2	2	4	2.072671	0	0.240000	3.570000	0.385908	0.990000	0.750000	1.000000	1.000000	0.984272	0.990000	1	9.900000e-01	1
GAS2L3	283431	broad.mit.edu	37	12	101005850	101005850	+	Missense_Mutation	SNP	G	G	A	rs143611209	byFrequency	TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr12:101005850G>A	ENST00000539410.1	+	5	762	c.376G>A	c.(376-378)Gca>Aca	p.A126T	GAS2L3_ENST00000547754.1_Missense_Mutation_p.A126T|GAS2L3_ENST00000266754.5_Missense_Mutation_p.A126T|GAS2L3_ENST00000537247.1_Missense_Mutation_p.A22T			Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3			35					GGACAATACCGCAAACTTCCT	0.378000																								0							SO:0001583	missense			ENST00000539410.1	0	1	hg19	CCDS9079.1	.	.	.	.	.	.	.	.	.	.	G	35	5.579672	0.96565	.	.	ENSG00000139354	ENST00000266754;ENST00000547754;ENST00000537247;ENST00000539410	T;T;T;T	0.42900	0.96;0.96;0.96;0.96	5.81	5.81	0.92471	Calponin homology domain (5);	0.054165	0.85682	D	0.000000	T	0.62036	0.2395	M	0.78916	2.43	0.53005	D	0.999965	D	0.55172	0.97	P	0.54590	0.756	T	0.62426	-0.6857	10	0.49607	T	0.09	-10.3724	20.1345	0.98019	0.0:0.0:1.0:0.0	.	126	Q86XJ1	GA2L3_HUMAN	T	126;126;22;126	ENSP00000266754:A126T;ENSP00000448955:A126T;ENSP00000442406:A22T;ENSP00000439672:A126T	ENSP00000266754:A126T	A	+	1	0	GAS2L3	99529981	1.000000	0.71417	0.994000	0.49952	0.980000	0.70556	9.437000	0.97535	2.763000	0.94921	0.558000	0.71614	GCA		TCGA-2J-AABO-01A-21D-A40W-08	GAS2L3-201	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000409143.1	0	0	0	5	648	0	100	0	0	0	1	0	100	2		0	0	0	0	0	2	1	0.935449	5	639	0	96	2								-1.860603	0	1	0	0		1	1	3	4	1.990121	1	0.240000	3.570000	0.364973	0.080000	0.010000	1.000000	0.070000	0.217280	0.080000	0	5.000000e-02	1.800000e-01
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	targeted			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr12:25398284C>A	ENST00000256078.4	-	2	98	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V	NM_033360.2	NP_203524.1	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)		GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		pancreatic, colorectal, lung, thyroid, AML, others				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)		Dom	yes		12	12p12.1	3845	v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog		L, E, M, O	15813	Substitution - Missense(15812)|Deletion - Frameshift(1)						SO:0001583	missense	Familial Cancer Database	Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS	ENST00000256078.4	1	1	hg19	CCDS8703.1	.	.	.	.	.	.	.	.	.	.	C	27.2	4.808637	0.90707	.	.	ENSG00000133703	ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131	T;T;T;T	0.78707	-1.2;-1.2;-1.2;-1.2	5.68	5.68	0.88126	Small GTP-binding protein domain (1);	0.000000	0.85682	D	0.000000	D	0.90373	0.6987	M	0.90650	3.135	0.80722	D	1	D;D	0.76494	0.997;0.999	D;D	0.72625	0.969;0.978	D	0.91773	0.5429	10	0.72032	D	0.01	.	18.3719	0.90409	0.0:1.0:0.0:0.0	.	12;12	P01116-2;P01116	.;RASK_HUMAN	V	12	ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V	ENSP00000256078:G12V	G	-	2	0	KRAS	25289551	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	7.743000	0.85020	2.668000	0.90789	0.563000	0.77884	GGT		TCGA-2J-AABO-01A-21D-A40W-08	KRAS-004	KNOWN	not_organism_supported|basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000412232.1	1	0	1	66	169	0	59	1	7.045758e-01	6	2	0	59	2	1	1	112	312	0	212	2	1	1.000000	66	168	0	59	2								-20.000000	1	1	0	0		1	1	3	4	2.055815	1	0.240000	3.570000	0.387097	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
KRT83	3889	broad.mit.edu	37	12	52715017	52715017	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr12:52715017C>T	ENST00000293670.3	-	1	165	c.103G>A	c.(103-105)Gcc>Acc	p.A35T		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83			32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)				CGGTAGGGGGCGGCGGTGATG	0.697000													GBM(41;747 834 12702 24089 39393)|Esophageal Squamous(97;805 1414 12559 28198 31861)											0							SO:0001583	missense			ENST00000293670.3	1	1	hg19	CCDS8823.1	.	.	.	.	.	.	.	.	.	.	C	13.92	2.379703	0.42207	.	.	ENSG00000170523	ENST00000293670	D	0.87412	-2.25	4.55	3.66	0.41972	.	0.000000	0.34580	U	0.003842	T	0.82181	0.4981	M	0.69358	2.11	0.29299	N	0.868803	B	0.15719	0.014	B	0.12837	0.008	T	0.74051	-0.3789	10	0.44086	T	0.13	.	3.659	0.08232	0.1679:0.577:0.163:0.0922	.	35	P78385	KRT83_HUMAN	T	35	ENSP00000293670:A35T	ENSP00000293670:A35T	A	-	1	0	KRT83	51001284	0.004000	0.15560	1.000000	0.80357	0.942000	0.58702	0.668000	0.25127	1.270000	0.44297	-0.140000	0.14226	GCC		TCGA-2J-AABO-01A-21D-A40W-08	KRT83-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000405182.1	0	0	1	29	271	1	65		0	0	0	1	65	2		0	0	0	0	0	2	1	1.000000	26	249	0	60	2								-3.075756	1	1	0	0		1	1	3	4	1.990121	1	0.240000	3.570000	0.364973	0.990000	0.670000	1.000000	1.000000	0.934424	0.990000	1	8.200000e-01	1
OR6C6	283365	broad.mit.edu	37	12	55688832	55688832	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr12:55688832C>T	ENST00000358433.2	-	1	184	c.185G>A	c.(184-186)cGt>cAt	p.R62H		NM_001005493.1	NP_001005493.1	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C, member 6			20					GGAGAAATTACGGAGAAAGAA	0.388000																								0							SO:0001583	missense			ENST00000358433.2	1	1	hg19	CCDS31817.1	.	.	.	.	.	.	.	.	.	.	-	3.881	-0.025966	0.07589	.	.	ENSG00000188324	ENST00000358433	T	0.01084	5.36	4.24	0.321	0.15883	GPCR, rhodopsin-like superfamily (1);	0.000000	0.43919	D	0.000517	T	0.01800	0.0057	M	0.84219	2.685	0.09310	N	1	B	0.15719	0.014	B	0.12837	0.008	T	0.43065	-0.9414	10	0.66056	D	0.02	.	2.1956	0.03910	0.1224:0.4226:0.1199:0.335	.	62	A6NF89	OR6C6_HUMAN	H	62	ENSP00000351211:R62H	ENSP00000351211:R62H	R	-	2	0	OR6C6	53975099	0.000000	0.05858	0.001000	0.08648	0.063000	0.16089	-1.335000	0.02662	-0.046000	0.13446	-1.274000	0.01402	CGT		TCGA-2J-AABO-01A-21D-A40W-08	OR6C6-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000398151.1	1	0	0	25	259	0	45		0	0	0	0	45	2		0	0	0	0	0	2	1	1.000000	25	259	0	42	2								-3.318793	1	1	121400	3	39	1	1	3	4	1.990121	1	0.240000	3.570000	0.364973	0.920000	0.600000	1.000000	1.000000	0.888341	0.920000	1	7.400000e-01	1
ITGA7	3679	broad.mit.edu	37	12	56082681	56082681	+	Missense_Mutation	SNP	G	G	A	rs17857368		TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr12:56082681G>A	ENST00000555728.1	-	23	3065	c.3037C>T	c.(3037-3039)Cgc>Tgc	p.R1013C	ITGA7_ENST00000452168.2_Missense_Mutation_p.R876C|ITGA7_ENST00000394229.2_Missense_Mutation_p.R969C|ITGA7_ENST00000553804.1_Missense_Mutation_p.R973C|ITGA7_ENST00000347027.6_Missense_Mutation_p.R963C|ITGA7_ENST00000257880.7_Missense_Mutation_p.R1013C|ITGA7_ENST00000257879.6_Missense_Mutation_p.R969C|ITGA7_ENST00000394230.2_Missense_Mutation_p.R973C			Q13683	ITA7_HUMAN	integrin, alpha 7			50					ACAGCCGCGCGGTCAAAGCTG	0.587000																								0							SO:0001583	missense			ENST00000555728.1	1	1	hg19		.	.	.	.	.	.	.	.	.	.	G	15.11	2.737426	0.49045	0.0	1.16E-4	ENSG00000135424	ENST00000553804;ENST00000257879;ENST00000347027;ENST00000452168;ENST00000257880;ENST00000394230;ENST00000394229;ENST00000353687;ENST00000555728	T;T;T;T;T;T;T;T	0.53206	0.63;0.63;0.63;0.63;0.63;0.63;0.63;0.63	5.45	4.56	0.56223	.	0.203366	0.42682	D	0.000663	T	0.52613	0.1745	L	0.50333	1.59	0.42430	D	0.992676	D;P;D;D	0.67145	0.959;0.843;0.984;0.996	P;P;P;P	0.51701	0.663;0.462;0.663;0.677	T	0.57365	-0.7824	10	0.62326	D	0.03	.	13.5445	0.61695	0.0:0.0:0.843:0.157	.	876;1013;973;1032	Q13683-13;Q13683;Q13683-3;Q4LE35	.;ITA7_HUMAN;.;.	C	973;969;963;876;1013;973;969;842;1013	ENSP00000452120:R973C;ENSP00000257879:R969C;ENSP00000343009:R963C;ENSP00000393844:R876C;ENSP00000257880:R1013C;ENSP00000377777:R973C;ENSP00000377776:R969C;ENSP00000452387:R1013C	ENSP00000257879:R969C	R	-	1	0	ITGA7	54368948	1.000000	0.71417	0.992000	0.48379	0.204000	0.24138	3.754000	0.55189	1.311000	0.45024	-0.164000	0.13417	CGC		TCGA-2J-AABO-01A-21D-A40W-08	ITGA7-014	KNOWN	basic	protein_coding	protein_coding	OTTHUMT00000410138.1	1	0	0	12	286	0	40	0	4.626831e-02	0	8	0	40	2		0	0	0	0	0	2	1	0.999036	11	280	0	38	2								-2.695214	1	1	121412	2	35	1	1	3	4	1.990121	1	0.240000	3.570000	0.364973	0.430000	0.220000	1.000000	0.400000	0.508979	0.430000	0	3.100000e-01	6.900000e-01
ERBB3	2065	broad.mit.edu	37	12	56480377	56480377	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr12:56480377G>T	ENST00000267101.3	+	4	924	c.484G>T	c.(484-486)Gac>Tac	p.D162Y	ERBB3_ENST00000450146.2_Intron|ERBB3_ENST00000415288.2_Missense_Mutation_p.D103Y	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3			8			OV - Ovarian serous cystadenocarcinoma(18;0.112)		GGACACAATTGACTGGAGGGA	0.502000																								0							SO:0001583	missense			ENST00000267101.3	0	1	hg19	CCDS31833.1	.	.	.	.	.	.	.	.	.	.	G	6.957	0.546455	0.13312	.	.	ENSG00000065361	ENST00000549061;ENST00000267101;ENST00000394099;ENST00000549672;ENST00000415288	D;D;D;D	0.84070	-1.8;-1.8;-1.8;-1.8	5.81	5.81	0.92471	EGF receptor, L domain (1);	0.073073	0.56097	D	0.000028	T	0.80188	0.4577	M	0.66439	2.03	0.80722	D	1	P	0.38863	0.65	B	0.33392	0.163	T	0.78157	-0.2313	10	0.22706	T	0.39	.	17.0026	0.86384	0.0:0.0:1.0:0.0	.	162	P21860	ERBB3_HUMAN	Y	103;162;162;103;103	ENSP00000449138:D103Y;ENSP00000267101:D162Y;ENSP00000449713:D103Y;ENSP00000408340:D103Y	ENSP00000267101:D162Y	D	+	1	0	ERBB3	54766644	0.848000	0.29623	0.998000	0.56505	0.995000	0.86356	1.181000	0.32017	2.753000	0.94483	0.650000	0.86243	GAC		TCGA-2J-AABO-01A-21D-A40W-08	ERBB3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000407619.3	0	0	0	8	587	0	135	0	6.569473e-02	0	27	0	135	2		0	0	0	0	0	2	1	0.988919	8	580	0	133	2								-2.844475	1	1	0	0		1	1	3	4	1.990121	1	0.240000	3.570000	0.364973	0.150000	0.050000	1.000000	0.140000	0.268143	0.150000	0	9.000000e-02	2.700000e-01
DGKH	160851	broad.mit.edu	37	13	42764629	42764629	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr13:42764629C>A	ENST00000337343.4	+	16	2024	c.2003C>A	c.(2002-2004)gCt>gAt	p.A668D	DGKH_ENST00000540693.1_Missense_Mutation_p.A668D|DGKH_ENST00000261491.5_Missense_Mutation_p.A668D|DGKH_ENST00000379274.2_Missense_Mutation_p.A532D|DGKH_ENST00000536612.1_Missense_Mutation_p.A532D|DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000538674.1_Missense_Mutation_p.A423D	NM_178009.3	NP_821077.1	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta			43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)			AAGGAGGAAGCTAAAGATGAT	0.373000																								0							SO:0001583	missense			ENST00000337343.4	1	1	hg19	CCDS9381.1	.	.	.	.	.	.	.	.	.	.	C	0.116	-1.132353	0.01756	.	.	ENSG00000102780	ENST00000540693;ENST00000337343;ENST00000261491;ENST00000379274;ENST00000536612;ENST00000538674	T;T;T;T;T;T	0.79749	-1.3;-1.13;-1.3;-1.3;-1.3;1.95	4.33	-1.13	0.09775	.	3.830580	0.00397	N	0.000049	T	0.56232	0.1971	N	0.03608	-0.345	0.09310	N	1	B;B;B;B	0.02656	0.0;0.0;0.0;0.0	B;B;B;B	0.06405	0.001;0.002;0.002;0.001	T	0.45279	-0.9272	10	0.26408	T	0.33	.	0.5744	0.00701	0.2823:0.3223:0.1171:0.2784	.	423;532;668;668	F5GYP2;Q86XP1-3;Q86XP1-2;Q86XP1	.;.;.;DGKH_HUMAN	D	668;668;668;532;532;423	ENSP00000440823:A668D;ENSP00000337572:A668D;ENSP00000261491:A668D;ENSP00000368576:A532D;ENSP00000445114:A532D;ENSP00000441308:A423D	ENSP00000261491:A668D	A	+	2	0	DGKH	41662629	0.003000	0.15002	0.000000	0.03702	0.000000	0.00434	0.070000	0.14573	-0.164000	0.10927	-0.482000	0.04802	GCT		TCGA-2J-AABO-01A-21D-A40W-08	DGKH-004	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000044699.2	0	0	0	39	459	0	99	0	6.546906e-03	0	2	0	99	2		0	0	0	0	0	2	1	1.000000	39	453	0	97	2								-10.809240	1	1	0	0		1	2	2	4	2.050496	0	0.240000	3.570000	0.378679	0.810000	0.580000	1.000000	1.000000	0.818850	0.810000	0	6.800000e-01	9.700000e-01
LMO7	4008	broad.mit.edu	37	13	76379654	76379654	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr13:76379654G>A	ENST00000321797.8	+	7	976	c.255G>A	c.(253-255)tgG>tgA	p.W85*	LMO7_ENST00000357063.3_Nonsense_Mutation_p.W370*|LMO7_ENST00000526202.1_Intron|LMO7_ENST00000377534.3_Nonsense_Mutation_p.W370*|LMO7_ENST00000465261.2_Nonsense_Mutation_p.W85*|LMO7_ENST00000341547.4_Intron|RP11-29G8.3_ENST00000563635.1_RNA			Q8WWI1	LMO7_HUMAN	LIM domain 7			56		Breast(118;0.0992)			TGGAGAACTGGCCAACTGTAC	0.408000																								0							SO:0001587	stop_gained			ENST00000321797.8	0	1	hg19		.	.	.	.	.	.	.	.	.	.	G	47	13.323881	0.99734	.	.	ENSG00000136153	ENST00000357063;ENST00000377534;ENST00000321797;ENST00000465261;ENST00000526371	.	.	.	5.93	5.08	0.68730	.	0.736359	0.13017	N	0.420363	.	.	.	.	.	.	0.80722	A	1	.	.	.	.	.	.	.	.	.	.	0.41790	T	0.15	-3.7943	7.9747	0.30149	0.1313:0.0:0.7356:0.1331	.	.	.	.	X	370;370;85;85;85	.	ENSP00000317802:W85X	W	+	3	0	LMO7	75277655	0.959000	0.32827	0.897000	0.35233	0.811000	0.45836	1.639000	0.37176	1.499000	0.48617	0.563000	0.77884	TGG		TCGA-2J-AABO-01A-21D-A40W-08	LMO7-005	PUTATIVE	alternative_5_UTR|not_organism_supported|basic|exp_conf	protein_coding	protein_coding	OTTHUMT00000045301.3	0	0	0	5	424	0	57		0	0	0	0	57	2		0	0	0	0	0	2	1	0.935549	5	418	0	55	2								-2.618869	1	1	0	0		1	2	2	4	2.050496	0	0.240000	3.570000	0.378679	0.130000	0.040000	1.000000	0.120000	0.189220	0.130000	0	8.000000e-02	2.200000e-01
TINF2	26277	broad.mit.edu	37	14	24709046	24709046	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr14:24709046G>T	ENST00000267415.7	-	9	1654	c.1313C>A	c.(1312-1314)cCt>cAt	p.P438H	TINF2_ENST00000540705.1_Missense_Mutation_p.P403H|TINF2_ENST00000558566.1_3'UTR|TINF2_ENST00000558510.1_5'Flank|TINF2_ENST00000538777.1_3'UTR|TINF2_ENST00000399423.4_3'UTR	NM_001099274.1	NP_001092744.1	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2			7					GGAAGAAACAGGTATGGCACC	0.458000									Congenital Dyskeratosis;Ataxia Pancytopenia syndrome															0							SO:0001583	missense	Familial Cancer Database	Zinsser-Engman-Cole syndrome, Dyskeratosis Congenita;Myelocerebellar disorder	ENST00000267415.7	1	1	hg19	CCDS41936.1	.	.	.	.	.	.	.	.	.	.	G	12.07	1.828471	0.32329	.	.	ENSG00000092330	ENST00000267415;ENST00000540705	D;D	0.84660	-1.88;-1.88	5.49	2.15	0.27550	.	1.805250	0.04023	U	0.300076	T	0.79707	0.4492	N	0.19112	0.55	0.09310	N	1	D;D	0.58268	0.982;0.982	P;P	0.47376	0.545;0.545	T	0.69117	-0.5230	10	0.62326	D	0.03	1.8398	5.8468	0.18671	0.1971:0.1654:0.6375:0.0	.	403;438	B4DFJ1;Q9BSI4	.;TINF2_HUMAN	H	438;403	ENSP00000267415:P438H;ENSP00000442154:P403H	ENSP00000267415:P438H	P	-	2	0	TINF2	23778886	0.004000	0.15560	0.001000	0.08648	0.016000	0.09150	1.259000	0.32956	0.641000	0.30601	0.563000	0.77884	CCT		TCGA-2J-AABO-01A-21D-A40W-08	TINF2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000415406.2	1	0	1	40	266	0	50	1	9.999532e-01	14	88	0	50	2		0	0	0	0	0	2	1	1.000000	38	260	0	49	2								-2.745157	1	1	0	0		1	0	4	4	2.068840	1	0.240000	3.570000	0.387097	0.990000	0.990000	1.000000	1.000000	0.998523	0.990000	1	9.900000e-01	1
SEC23A	10484	broad.mit.edu	37	14	39524367	39524367	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr14:39524367C>T	ENST00000307712.6	-	14	2156	c.1639G>A	c.(1639-1641)Gac>Aac	p.D547N	SEC23A_ENST00000536508.1_Missense_Mutation_p.D421N|SEC23A_ENST00000537403.1_Missense_Mutation_p.D345N|SEC23A_ENST00000545328.2_Missense_Mutation_p.D518N	NM_006364.2	NP_006355.2	Q15436	SC23A_HUMAN	Sec23 homolog A (S. cerevisiae)			23	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)		AGCTGTCTGTCCAGCCACCTA	0.418000																								0							SO:0001583	missense			ENST00000307712.6	0	1	hg19	CCDS9668.1	.	.	.	.	.	.	.	.	.	.	C	34	5.354537	0.95854	.	.	ENSG00000100934	ENST00000537403;ENST00000307712;ENST00000536508;ENST00000545328	D;D;D;D	0.97041	-4.22;-4.22;-4.22;-4.22	5.81	4.93	0.64822	Sec23/Sec24, helical domain (2);	0.151418	0.64402	N	0.000016	D	0.99026	0.9667	H	0.97390	3.995	0.80722	D	1	D;D;D	0.89917	1.0;1.0;1.0	D;D;D	0.97110	0.999;0.999;1.0	D	0.99120	1.0849	10	0.87932	D	0	-14.9158	14.8974	0.70654	0.0:0.9311:0.0:0.0689	.	518;421;547	F5H365;F5H6C4;Q15436	.;.;SC23A_HUMAN	N	345;547;421;518	ENSP00000444193:D345N;ENSP00000306881:D547N;ENSP00000437715:D421N;ENSP00000445393:D518N	ENSP00000306881:D547N	D	-	1	0	SEC23A	38594118	1.000000	0.71417	1.000000	0.80357	0.996000	0.88848	7.653000	0.83643	1.461000	0.47929	0.551000	0.68910	GAC		TCGA-2J-AABO-01A-21D-A40W-08	SEC23A-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000276728.2	0	0	0	6	524	1	96	0	5.623986e-03	0	47	1	96	4		0	0	0	0	0	2	0	0.006153	6	518	1	95	19								-2.919573	1	1	0	0		1	0	4	4	2.068840	1	0.240000	3.570000	0.387097	0.120000	0.040000	0.240000	0.120000	0.135605	0.120000	0	7.000000e-02	1.900000e-01
DACT1	51339	broad.mit.edu	37	14	59113461	59113461	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr14:59113461C>T	ENST00000335867.4	+	4	2144	c.2120C>T	c.(2119-2121)gCg>gTg	p.A707V	DACT1_ENST00000556859.1_Missense_Mutation_p.A426V|DACT1_ENST00000395153.3_Missense_Mutation_p.A670V|DACT1_ENST00000541264.2_Missense_Mutation_p.A426V			Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1			53					CTGTACCCCGCGCCTGTGCCT	0.677000																								0							SO:0001583	missense			ENST00000335867.4	1	1	hg19	CCDS9736.1	.	.	.	.	.	.	.	.	.	.	C	2.952	-0.216568	0.06101	.	.	ENSG00000165617	ENST00000556859;ENST00000395151;ENST00000395153;ENST00000335867;ENST00000541264	T;T;T;T;T	0.46819	0.86;0.86;0.86;0.86;0.86	4.78	1.38	0.22167	.	0.637842	0.14878	N	0.293151	T	0.36468	0.0968	L	0.41961	1.31	0.09310	N	1	B;B	0.13594	0.008;0.001	B;B	0.09377	0.004;0.002	T	0.22173	-1.0224	10	0.33940	T	0.23	-4.5278	9.1246	0.36807	0.0:0.7656:0.139:0.0955	.	670;707	A8MYJ2;Q9NYF0	.;DACT1_HUMAN	V	426;426;670;707;426	ENSP00000451598:A426V;ENSP00000378581:A426V;ENSP00000378582:A670V;ENSP00000337439:A707V;ENSP00000442850:A426V	ENSP00000337439:A707V	A	+	2	0	DACT1	58183214	0.000000	0.05858	0.001000	0.08648	0.024000	0.10985	0.296000	0.19083	0.157000	0.19338	-0.223000	0.12442	GCG		TCGA-2J-AABO-01A-21D-A40W-08	DACT1-004	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000325515.1	1	0	0	14	237	0	60	0	3.306226e-01	0	20	0	60	2		0	0	0	0	0	2	1	0.999722	14	230	0	56	2								-17.218900	1	1	0	0		1	0	5	5	2.223129	1	0.240000	3.570000	0.441176	0.640000	0.370000	1.000000	1.000000	0.665385	0.640000	0	4.900000e-01	8.300000e-01
KCNH5	27133	broad.mit.edu	37	14	63174356	63174356	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr14:63174356C>T	ENST00000322893.7	-	11	3105	c.2837G>A	c.(2836-2838)aGc>aAc	p.S946N	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5			99					CTGGGGTACGCTTTTTTCCGA	0.473000																								0							SO:0001583	missense			ENST00000322893.7	1	1	hg19	CCDS9756.1	.	.	.	.	.	.	.	.	.	.	C	0	-2.657147	0.00108	.	.	ENSG00000140015	ENST00000322893	D	0.98889	-5.21	5.66	3.73	0.42828	.	0.225680	0.49916	D	0.000128	D	0.93354	0.7881	N	0.14661	0.345	0.80722	D	1	B	0.02656	0.0	B	0.04013	0.001	D	0.86737	0.1952	10	0.16896	T	0.51	.	3.934	0.09298	0.1606:0.5698:0.1557:0.1139	.	946	Q8NCM2	KCNH5_HUMAN	N	946	ENSP00000321427:S946N	ENSP00000321427:S946N	S	-	2	0	KCNH5	62244109	0.037000	0.19845	0.959000	0.39883	0.058000	0.15608	0.257000	0.18369	2.832000	0.97577	0.655000	0.94253	AGC		TCGA-2J-AABO-01A-21D-A40W-08	KCNH5-004	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000411747.1	1	0	0	93	998	1	132		0	0	0	1	132	2		0	0	0	0	0	2	1	1.000000	91	990	0	130	2								-19.913390	1	1	0	0		1	0	5	5	2.223129	1	0.240000	3.570000	0.441176	0.960000	0.780000	1.000000	1.000000	0.945964	0.960000	1	8.700000e-01	1
APBA2	321	broad.mit.edu	37	15	29346967	29346967	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr15:29346967G>A	ENST00000558402.1	+	5	1479	c.880G>A	c.(880-882)Gga>Aga	p.G294R	APBA2_ENST00000411764.1_Missense_Mutation_p.G294R|APBA2_ENST00000558259.1_Missense_Mutation_p.G294R|APBA2_ENST00000558330.1_Missense_Mutation_p.G294R|APBA2_ENST00000561069.1_Missense_Mutation_p.G294R			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2			59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)			CAAGCACCCCGGAGACCCCCA	0.662000																								0							SO:0001583	missense			ENST00000558402.1	1	1	hg19	CCDS10022.1	.	.	.	.	.	.	.	.	.	.	G	3.639	-0.073870	0.07184	0.0	1.17E-4	ENSG00000034053	ENST00000411764;ENST00000219865	T	0.29655	1.56	4.96	3.08	0.35506	.	0.685293	0.14091	N	0.342030	T	0.24122	0.0584	L	0.50333	1.59	0.09310	N	0.999998	P;P;P	0.49447	0.924;0.848;0.924	B;B;B	0.40940	0.344;0.271;0.344	T	0.07328	-1.0778	10	0.17369	T	0.5	.	7.6919	0.28573	0.2545:0.0:0.7455:0.0	.	294;294;294	Q5XKC0;E9PGI4;Q99767	.;.;APBA2_HUMAN	R	294	ENSP00000409312:G294R	ENSP00000219865:G294R	G	+	1	0	APBA2	27134259	0.997000	0.39634	0.217000	0.23759	0.186000	0.23388	3.084000	0.50143	1.075000	0.40932	-0.143000	0.13931	GGA		TCGA-2J-AABO-01A-21D-A40W-08	APBA2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000251362.3	1	0	0	9	155	0	24	0	1.226170e-01	0	10	0	24	2		0	0	0	0	0	2	1	0.994147	9	152	0	21	2								-12.114530	1	1	121178	6	36	1	3	3	6	2.520175	1	0.240000	3.570000	0.486486	0.700000	0.350000	1.000000	1.000000	0.719593	0.700000	0	5.000000e-01	9.500000e-01
TMEM87A	25963	broad.mit.edu	37	15	42503943	42503943	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr15:42503943C>T	ENST00000389834.4	-	20	1895	c.1631G>A	c.(1630-1632)cGa>cAa	p.R544Q	RP11-546B15.1_ENST00000563846.1_RNA|RP11-546B15.1_ENST00000561800.1_RNA|TMEM87A_ENST00000448392.1_Missense_Mutation_p.R483Q	NM_015497.3	NP_056312.2	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A			24		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)			TGTGATCATTCGTTCCTAGGG	0.368000																								0							SO:0001583	missense			ENST00000389834.4	1	1	hg19	CCDS32205.1	.	.	.	.	.	.	.	.	.	.	C	14.77	2.635366	0.47049	.	.	ENSG00000103978	ENST00000389834;ENST00000448392;ENST00000535305	.	.	.	5.37	4.46	0.54185	.	0.085860	0.49305	D	0.000141	T	0.31796	0.0808	N	0.19112	0.55	0.33298	D	0.564466	D	0.64830	0.994	P	0.47102	0.537	T	0.36866	-0.9730	9	0.20519	T	0.43	-6.2906	12.5403	0.56165	0.0:0.9238:0.0:0.0762	.	544	Q8NBN3	TM87A_HUMAN	Q	544;483;520	.	ENSP00000374484:R544Q	R	-	2	0	TMEM87A	40291235	1.000000	0.71417	1.000000	0.80357	0.456000	0.32438	2.962000	0.49176	1.501000	0.48654	-0.145000	0.13849	CGA		TCGA-2J-AABO-01A-21D-A40W-08	TMEM87A-001	KNOWN	non_canonical_U12|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000420482.2	0	0	0	66	940	0	142	1	9.996362e-01	12	150	0	142	2		0	0	0	0	0	2	1	1.000000	66	918	0	139	2								-10.638730	1	1	0	0		1	3	3	6	2.491455	1	0.240000	3.570000	0.486486	0.800000	0.620000	1.000000	1.000000	0.817080	0.800000	0	7.100000e-01	9.100000e-01
VPS13C	54832	broad.mit.edu	37	15	62283987	62283987	+	Silent	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr15:62283987C>T	ENST00000261517.5	-	17	1441	c.1368G>A	c.(1366-1368)ggG>ggA	p.G456G	VPS13C_ENST00000395896.4_Silent_p.G456G|VPS13C_ENST00000395898.3_Silent_p.G413G|VPS13C_ENST00000249837.3_Silent_p.G413G	NM_020821.2	NP_065872.1			vacuolar protein sorting 13 homolog C (S. cerevisiae)	p.G456G(1)		117					TTAATTTTTGCCCAGACCGAA	0.383000																								1	Substitution - coding silent(1)						SO:0001819	synonymous_variant			ENST00000261517.5	0	1	hg19	CCDS32257.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	VPS13C-002	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000415997.1	0	0	0	7	945	0	120		0	0	0	0	120	2		0	0	0	0	0	2	1	0.979791	7	934	0	119	2								-1.757035	0	1	121412	10	43	1	3	3	6	2.491455	1	0.240000	3.570000	0.486486	0.090000	0.010000	0.190000	0.120000	0.101188	0.090000	0	4.000000e-02	1.400000e-01
PPCDC	60490	broad.mit.edu	37	15	75340906	75340906	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr15:75340906C>T	ENST00000342932.3	+	5	517	c.373C>T	c.(373-375)Cgg>Tgg	p.R125W	PPCDC_ENST00000563393.1_Missense_Mutation_p.R2W|PPCDC_ENST00000567336.1_Missense_Mutation_p.R93W|PPCDC_ENST00000564923.1_Missense_Mutation_p.R50W|PPCDC_ENST00000568649.1_Missense_Mutation_p.R82W	NM_021823.3	NP_068595.3	Q96CD2	COAC_HUMAN	phosphopantothenoylcysteine decarboxylase			2					CTGCGTCATGCGGGCCTGGGA	0.662000																								0							SO:0001583	missense			ENST00000342932.3	0	1	hg19	CCDS10275.1	.	.	.	.	.	.	.	.	.	.	C	25.0	4.593241	0.86953	.	.	ENSG00000138621	ENST00000342932	T	0.49720	0.77	5.49	5.49	0.81192	Flavoprotein (3);	0.050133	0.85682	D	0.000000	T	0.80308	0.4599	H	0.96720	3.87	0.80722	D	1	D	0.89917	1.0	D	0.97110	1.0	D	0.86798	0.1990	10	0.72032	D	0.01	-24.5121	18.3618	0.90377	0.0:1.0:0.0:0.0	.	125	Q96CD2	COAC_HUMAN	W	125	ENSP00000343190:R125W	ENSP00000343190:R125W	R	+	1	2	PPCDC	73127959	1.000000	0.71417	1.000000	0.80357	0.982000	0.71751	4.512000	0.60469	2.592000	0.87571	0.655000	0.94253	CGG		TCGA-2J-AABO-01A-21D-A40W-08	PPCDC-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000286416.1	0	0	0	5	421	1	62	0	7.783681e-03	0	26	1	62	3		0	0	0	0	0	2	0	0.000893	5	413	1	61	21								-2.386566	0	1	121412	1	34	1	3	3	6	2.508076	1	0.240000	3.570000	0.486486	0.150000	0.040000	0.320000	0.130000	0.172269	0.150000	0	9.000000e-02	2.400000e-01
ZNF646	9726	broad.mit.edu	37	16	31091179	31091179	+	Silent	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr16:31091179G>A	ENST00000394979.2	+	1	3957	c.3534G>A	c.(3532-3534)aaG>aaA	p.K1178K	ZNF646_ENST00000300850.5_Silent_p.K1178K			O15015	ZN646_HUMAN	zinc finger protein 646			49					CCACTGTGAAGGGGGAGGAGA	0.602000																								0							SO:0001819	synonymous_variant			ENST00000394979.2	0	1	hg19																																																																																					TCGA-2J-AABO-01A-21D-A40W-08	ZNF646-003	KNOWN	basic	protein_coding	protein_coding	OTTHUMT00000108510.2	1	0	0	11	88	0	23	1	2.466400e-01	2	6	0	23	2		0	0	0	0	0	2	1	0.998489	11	86	0	23	2								-17.758920	1	1	0	0		1	1	2	3	1.838746	1	0.240000	3.570000	0.317774	0.990000	0.570000	1.000000	1.000000	0.925121	0.990000	1	7.900000e-01	1
CDH8	1006	broad.mit.edu	37	16	62055291	62055291	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr16:62055291G>A	ENST00000577390.1	-	2	971	c.17C>T	c.(16-18)gCg>gTg	p.A6V	CDH8_ENST00000577730.1_Missense_Mutation_p.A6V|CDH8_ENST00000299345.6_Missense_Mutation_p.A6V|CDH8_ENST00000584337.1_Missense_Mutation_p.A6V	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2			112		Ovarian(137;0.0799)|Melanoma(118;0.16)			GAGCATTTCCGCTAGCCGTTC	0.423000																								0							SO:0001583	missense			ENST00000577390.1	1	0	hg19	CCDS10802.1	.	.	.	.	.	.	.	.	.	.	G	15.48	2.844972	0.51164	2.27E-4	0.0	ENSG00000150394	ENST00000299345	T	0.55234	0.53	6.17	3.2	0.36748	.	0.270757	0.37393	N	0.002101	T	0.28134	0.0694	N	0.08118	0	0.27497	N	0.952113	B	0.02656	0.0	B	0.01281	0.0	T	0.12243	-1.0555	10	0.38643	T	0.18	.	6.8503	0.24010	0.2007:0.1268:0.6724:0.0	.	6	P55286	CADH8_HUMAN	V	6	ENSP00000299345:A6V	ENSP00000299345:A6V	A	-	2	0	CDH8	60612792	1.000000	0.71417	1.000000	0.80357	0.997000	0.91878	1.806000	0.38892	0.946000	0.37632	0.655000	0.94253	GCG		TCGA-2J-AABO-01A-21D-A40W-08	CDH8-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000268754.3	1	0	0	45	484	0	120		0	0	0	0	120	2		0	0	0	0	0	2	1	1.000000	45	476	0	116	2								-1.422543	0	1	121172	12	41	1	2	2	4	2.042091	0	0.240000	3.570000	0.375000	0.870000	0.640000	1.000000	1.000000	0.874704	0.870000	1	7.500000e-01	1
GFOD2	81577	broad.mit.edu	37	16	67709902	67709902	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr16:67709902C>T	ENST00000268797.7	-	3	659	c.314G>A	c.(313-315)cGg>cAg	p.R105Q	GFOD2_ENST00000602377.1_5'UTR	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2			19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)			TGTCACCATCCGGAAGGCATC	0.537000																								0							SO:0001583	missense			ENST00000268797.7	0	1	hg19	CCDS10845.1	.	.	.	.	.	.	.	.	.	.	C	23.8	4.454598	0.84209	.	.	ENSG00000141098	ENST00000268797	T	0.23348	1.91	4.99	4.99	0.66335	Oxidoreductase, N-terminal (1);NAD(P)-binding domain (1);	0.102199	0.64402	D	0.000004	T	0.24005	0.0581	L	0.51853	1.615	0.36424	D	0.864483	B	0.34103	0.437	B	0.33392	0.163	T	0.17561	-1.0365	10	0.22706	T	0.39	-34.9241	13.9291	0.63983	0.0:0.8474:0.1525:0.0	.	105	Q3B7J2	GFOD2_HUMAN	Q	105	ENSP00000268797:R105Q	ENSP00000268797:R105Q	R	-	2	0	GFOD2	66267403	0.998000	0.40836	1.000000	0.80357	0.997000	0.91878	2.401000	0.44513	2.468000	0.83385	0.563000	0.77884	CGG		TCGA-2J-AABO-01A-21D-A40W-08	GFOD2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000268868.2	1	0	0	11	114	0	18	1	7.261357e-01	3	25	0	18	2		0	0	0	0	0	2	1	0.998583	11	114	0	17	2								-16.565900	1	1	121410	3	29	1	2	2	4	2.042091	0	0.240000	3.570000	0.375000	0.940000	0.500000	1.000000	1.000000	0.876350	0.940000	1	6.900000e-01	1
GPATCH8	23131	broad.mit.edu	37	17	42476539	42476539	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr17:42476539C>T	ENST00000591680.1	-	8	2936	c.2906G>A	c.(2905-2907)cGa>cAa	p.R969Q	GPATCH8_ENST00000434000.1_Missense_Mutation_p.R891Q	NM_001002909.2	NP_001002909.1	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8			50		Prostate(33;0.0181)			CCGCTTGCTTCGACTACGACT	0.642000																								0							SO:0001583	missense			ENST00000591680.1	1	1	hg19	CCDS32666.1	.	.	.	.	.	.	.	.	.	.	C	16.08	3.020141	0.54576	.	.	ENSG00000186566	ENST00000335500;ENST00000434000	T	0.13538	2.58	5.2	5.2	0.72013	.	0.064020	0.64402	D	0.000003	T	0.26738	0.0654	L	0.29908	0.895	0.58432	D	0.999998	D	0.89917	1.0	D	0.80764	0.994	T	0.01326	-1.1384	10	0.27785	T	0.31	-12.7963	18.9211	0.92525	0.0:1.0:0.0:0.0	.	969	Q9UKJ3	GPTC8_HUMAN	Q	969;891	ENSP00000395016:R891Q	ENSP00000335486:R969Q	R	-	2	0	GPATCH8	39832065	0.999000	0.42202	1.000000	0.80357	0.987000	0.75469	4.242000	0.58714	2.712000	0.92718	0.555000	0.69702	CGA		TCGA-2J-AABO-01A-21D-A40W-08	GPATCH8-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000457797.1	1	0	0	27	338	0	116	1	2.326852e-01	2	10	0	116	2		0	0	0	0	0	2	1	1.000000	26	323	0	110	2								-3.221887	1	1	121408	19	45	1	2	3	5	2.278406	1	0.240000	3.570000	0.439693	0.840000	0.570000	1.000000	1.000000	0.841535	0.840000	0	6.900000e-01	1
BZRAP1	9256	broad.mit.edu	37	17	56386380	56386380	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr17:56386380C>T	ENST00000343736.4	-	22	4416	c.4253G>A	c.(4252-4254)cGc>cAc	p.R1418H	BZRAP1_ENST00000355701.3_Missense_Mutation_p.R1418H|BZRAP1_ENST00000268893.6_Missense_Mutation_p.R1358H			O95153	RIMB1_HUMAN	benzodiazepine receptor (peripheral) associated protein 1			54	Medulloblastoma(34;0.127)|all_neural(34;0.237)				AGGCCGCCTGCGGCTTGGGGG	0.662000																								0							SO:0001583	missense			ENST00000343736.4	1	0	hg19	CCDS11605.1	.	.	.	.	.	.	.	.	.	.	c	11.12	1.545017	0.27652	.	.	ENSG00000005379	ENST00000355701;ENST00000343736;ENST00000268893	T;T;T	0.04809	3.55;3.55;3.56	5.31	3.32	0.38043	.	0.745690	0.13368	N	0.393144	T	0.04998	0.0134	L	0.32530	0.975	0.25701	N	0.98559	B;B;B	0.21821	0.042;0.061;0.036	B;B;B	0.16722	0.011;0.016;0.007	T	0.33394	-0.9870	10	0.87932	D	0	.	9.0355	0.36284	0.0:0.775:0.1461:0.0789	.	1418;1358;1418	B7ZVZ7;O95153-2;O95153	.;.;RIMB1_HUMAN	H	1418;1418;1358	ENSP00000347929:R1418H;ENSP00000345824:R1418H;ENSP00000268893:R1358H	ENSP00000268893:R1358H	R	-	2	0	BZRAP1	53741379	0.997000	0.39634	0.935000	0.37517	0.512000	0.34134	1.834000	0.39171	0.637000	0.30526	-0.215000	0.12644	CGC		TCGA-2J-AABO-01A-21D-A40W-08	BZRAP1-002	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000443980.1	1	0	0	70	668	0	124	0	4.887261e-02	0	4	0	124	2		0	0	0	0	0	2	1	1.000000	40	371	0	72	2								-19.218360	1	1	119702	3	40	1	2	3	5	2.291502	1	0.240000	3.570000	0.441176	0.990000	0.840000	1.000000	1.000000	0.982853	0.990000	1	9.500000e-01	1
TEX14	56155	broad.mit.edu	37	17	56663333	56663333	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr17:56663333C>T	ENST00000240361.8	-	18	3002	c.2917G>A	c.(2917-2919)Gcc>Acc	p.A973T	TEX14_ENST00000349033.5_Missense_Mutation_p.A967T|TEX14_ENST00000389934.3_Missense_Mutation_p.A967T			Q8IWB6	TEX14_HUMAN	testis expressed 14			81	Medulloblastoma(34;0.127)|all_neural(34;0.237)				TGCAGCAGGGCGTCGGGCTCA	0.507000																								0							SO:0001583	missense			ENST00000240361.8	0	1	hg19	CCDS56042.1	1	4.578754578754579E-4	0	0.0	0	0.0	1	0.0017482517482517483	0	0.0	C	16.33	3.094030	0.56075	2.27E-4	0.0	ENSG00000121101	ENST00000240361;ENST00000389934;ENST00000349033	T;T;T	0.81163	-1.46;-1.46;-1.42	5.38	0.501	0.16925	.	0.525270	0.18903	N	0.128000	T	0.63283	0.2498	L	0.29908	0.895	0.09310	N	1	P;P;P	0.49185	0.87;0.92;0.92	B;B;B	0.40165	0.171;0.321;0.321	T	0.56872	-0.7907	10	0.40728	T	0.16	-1.9391	4.4542	0.11635	0.2296:0.3843:0.3861:0.0	.	973;967;967	Q8IWB6;Q8IWB6-3;Q8IWB6-2	TEX14_HUMAN;.;.	T	973;967;967	ENSP00000240361:A973T;ENSP00000374584:A967T;ENSP00000268910:A967T	ENSP00000240361:A973T	A	-	1	0	TEX14	54018332	0.000000	0.05858	0.026000	0.17262	0.021000	0.10359	-0.221000	0.09202	0.601000	0.29879	-0.311000	0.09066	GCC		TCGA-2J-AABO-01A-21D-A40W-08	TEX14-003	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000445446.1	0	0	0	9	724	0	144		0	0	0	0	144	2		0	0	0	0	0	2	1	0.993680	8	710	0	139	2								-2.665977	1	1	121412	6	42	1	2	3	5	2.291502	1	0.240000	3.570000	0.441176	0.140000	0.060000	0.260000	0.150000	0.153934	0.140000	0	9.000000e-02	2.000000e-01
UNC13D	201294	broad.mit.edu	37	17	73836181	73836181	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr17:73836181G>A	ENST00000207549.4	-	11	1248	c.869C>T	c.(868-870)tCg>tTg	p.S290L	UNC13D_ENST00000587504.1_5'UTR|UNC13D_ENST00000412096.2_Missense_Mutation_p.S290L	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)			29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)		GCGGCTGGCCGAAGTGGCTCT	0.667000									Familial Hemophagocytic Lymphohistiocytosis															0		GRCh37	CM060506	UNC13D	M		SO:0001583	missense	Familial Cancer Database	FHLH, FHL, Familial Hemophagocytic Reticulosis, FHR	ENST00000207549.4	0	1	hg19	CCDS11730.1	.	.	.	.	.	.	.	.	.	.	G	5.902	0.350463	0.11182	.	.	ENSG00000092929	ENST00000207549;ENST00000412096;ENST00000448606	T;T	0.71341	-0.54;-0.56	4.35	-8.7	0.00851	.	2.024690	0.02792	N	0.122211	T	0.38878	0.1057	N	0.04203	-0.255	0.09310	N	1	B;B	0.25486	0.001;0.127	B;B	0.14023	0.001;0.01	T	0.39981	-0.9587	10	0.33940	T	0.23	0.942	1.8052	0.03079	0.4553:0.1975:0.1707:0.1765	.	290;290	B4DTQ6;Q70J99	.;UN13D_HUMAN	L	290	ENSP00000207549:S290L;ENSP00000388093:S290L	ENSP00000207549:S290L	S	-	2	0	UNC13D	71347776	0.000000	0.05858	0.000000	0.03702	0.353000	0.29299	-1.869000	0.01643	-3.304000	0.00192	-1.008000	0.02478	TCG		TCGA-2J-AABO-01A-21D-A40W-08	UNC13D-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000448847.2	0	0	0	9	79	1	14	1	6.255246e-02	13	51	1	14	13		0	0	0	0	0	2	0	0.087055	8	79	1	14	16								-15.105500	1	1	121296	10	39	1	2	3	5	2.308995	1	0.240000	3.570000	0.441176	0.990000	0.600000	1.000000	1.000000	0.950712	0.990000	1	8.700000e-01	1
TP53	7157	broad.mit.edu	37	17	7577141	7577141	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	targeted			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr17:7577141C>A	ENST00000269305.4	-	8	986	c.797G>T	c.(796-798)gGa>gTa	p.G266V	TP53_ENST00000445888.2_Missense_Mutation_p.G266V|TP53_ENST00000574684.1_5'Flank|TP53_ENST00000455263.2_Missense_Mutation_p.G266V|TP53_ENST00000420246.2_Missense_Mutation_p.G266V|TP53_ENST00000359597.4_Missense_Mutation_p.G266V|TP53_ENST00000413465.2_Intron	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	p.G266E(50)|p.G266V(42)|p.0?(8)|p.?(3)|p.G266fs*79(3)|p.G262_F270delGNLLGRNSF(2)|p.G266A(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.G266T(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.L265_R267delLGR(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		Acetylsalicylic acid(DB00945)	GCTGTTCCGTCCCAGTAGATT	0.517000		111	Mis, N, F		breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types	breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			Pancreas(47;798 1329 9957 10801)	yes	Rec	yes	Li-Fraumeni syndrome	17	17p13	7157	tumor protein p53		L, E, M, O	121	Substitution - Missense(95)|Deletion - In frame(9)|Whole gene deletion(8)|Deletion - Frameshift(6)|Unknown(3)						SO:0001583	missense	Familial Cancer Database	Familial Osteogenic Sarcoma;LFS, SBLA syndrome (Sarcoma Breast Leukemia Adrenal cancer), incl.: Cancer with In Vitro Radioresistence, Familial, Li-Fraumeni-like s.;BRCAX;Familial Adrenocortical Carcinoma;	ENST00000269305.4	1	1	hg19	CCDS11118.1	.	.	.	.	.	.	.	.	.	.	C	23.2	4.388215	0.82902	.	.	ENSG00000141510	ENST00000359597;ENST00000269305;ENST00000455263;ENST00000420246;ENST00000445888;ENST00000396473;ENST00000509690	D;D;D;D;D;D	0.99900	-7.62;-7.62;-7.62;-7.62;-7.62;-7.62	5.13	5.13	0.70059	p53, DNA-binding domain (1);p53-like transcription factor, DNA-binding (1);p53/RUNT-type transcription factor, DNA-binding domain (1);	0.000000	0.85682	D	0.000000	D	0.99906	0.9955	M	0.92367	3.3	0.80722	D	1	D;D;D;D	0.89917	1.0;1.0;1.0;1.0	D;D;D;D	0.97110	0.999;1.0;0.999;0.999	D	0.96190	0.9137	10	0.87932	D	0	-13.0798	16.1198	0.81342	0.0:1.0:0.0:0.0	.	266;266;266;266	P04637-2;P04637-3;P04637;Q1MSW8	.;.;P53_HUMAN;.	V	266;266;266;266;266;255;134	ENSP00000352610:G266V;ENSP00000269305:G266V;ENSP00000398846:G266V;ENSP00000391127:G266V;ENSP00000391478:G266V;ENSP00000425104:G134V	ENSP00000269305:G266V	G	-	2	0	TP53	7517866	1.000000	0.71417	0.996000	0.52242	0.744000	0.42396	7.587000	0.82613	2.667000	0.90743	0.462000	0.41574	GGA		TCGA-2J-AABO-01A-21D-A40W-08	TP53-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000367397.1	1	0	1	27	48	0	22	1	9.998234e-01	15	15	0	22	2	1	1	208	578	1	501	8	1	1.000000	27	46	0	21	2								-20.000000	1	1	0	0		1	0	2	2	1.661646	1	0.240000	3.570000	0.240000	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
DSEL	92126	broad.mit.edu	37	18	65178609	65178609	+	Silent	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr18:65178609G>A	ENST00000310045.7	-	2	4740	c.3267C>T	c.(3265-3267)ttC>ttT	p.F1089F	CTD-2541J13.2_ENST00000581951.1_RNA|CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like			74		Esophageal squamous(42;0.129)			GTTCATACTCGAAAGCATAAC	0.368000																								0							SO:0001819	synonymous_variant			ENST00000310045.7	0	1	hg19	CCDS11995.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	DSEL-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000256221.1	0	0	0	6	337	0	92		0	0	0	0	92	2		0	0	0	0	0	2	1	0.963703	6	332	0	92	2								-4.185599	1	1	121310	3	37	1	0	1	1	1.481132	1	0.240000	3.570000	0.136364	0.130000	0.050000	0.260000	0.130000	0.146046	0.130000	0	8.000000e-02	2.000000e-01
LAMA1	284217	broad.mit.edu	37	18	7032156	7032156	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr18:7032156T>C	ENST00000389658.3	-	16	2276	c.2183A>G	c.(2182-2184)tAc>tGc	p.Y728C		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1			205		Colorectal(10;0.172)			ATCCACGCGGTAATAGCCAGA	0.478000																								0							SO:0001583	missense			ENST00000389658.3	1	1	hg19	CCDS32787.1	.	.	.	.	.	.	.	.	.	.	T	17.52	3.408948	0.62399	.	.	ENSG00000101680	ENST00000389658	T	0.64260	-0.09	5.51	5.51	0.81932	EGF-like, laminin (2);	0.084479	0.48767	D	0.000165	T	0.82217	0.4989	M	0.89715	3.055	0.49130	D	0.999755	D	0.89917	1.0	D	0.87578	0.998	D	0.85319	0.1083	10	0.54805	T	0.06	.	14.1917	0.65641	0.0:0.0:0.0:1.0	.	728	P25391	LAMA1_HUMAN	C	728	ENSP00000374309:Y728C	ENSP00000374309:Y728C	Y	-	2	0	LAMA1	7022156	1.000000	0.71417	0.990000	0.47175	0.741000	0.42261	3.955000	0.56715	2.080000	0.62538	0.533000	0.62120	TAC		TCGA-2J-AABO-01A-21D-A40W-08	LAMA1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000257369.1	1	0	0	10	145	0	23	0	0	0	1	0	23	2		0	0	0	0	0	2	1	0.996987	10	143	0	22	2								-14.117400	1	1	121412	1	27	1	1	4	5	2.180620	1	0.240000	3.570000	0.414844	0.760000	0.380000	1.000000	1.000000	0.768660	0.760000	0	5.400000e-01	1
ATP8B3	148229	broad.mit.edu	37	19	1791840	1791840	+	Silent	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr19:1791840G>A	ENST00000310127.6	-	20	2449	c.2211C>T	c.(2209-2211)atC>atT	p.I737I	ATP8B3_ENST00000539485.1_Silent_p.I747I|ATP8B3_ENST00000525591.1_Silent_p.I700I	NM_138813.3	NP_620168.1	O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3			23		Hepatocellular(1079;0.137)			GTCTGTCCTCGATGGCTGTGG	0.627000																								0							SO:0001819	synonymous_variant			ENST00000310127.6	0	1	hg19	CCDS45901.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	ATP8B3-002	KNOWN	alternative_5_UTR|basic|CCDS	protein_coding	protein_coding	OTTHUMT00000388279.1	0	0	0	4	195	0	65		0	0	0	0	65	2		0	0	0	0	0	2	1	0.886397	4	191	0	62	2								-5.622638	1	1	120282	5	36	1	2	2	4	1.898442	1	0.240000	3.570000	0.328622	0.250000	0.070000	1.000000	0.190000	0.416499	0.250000	0	1.400000e-01	1
RAX2	84839	broad.mit.edu	37	19	3771573	3771573	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr19:3771573G>T	ENST00000555633.1	-	2	508	c.168C>A	c.(166-168)agC>agA	p.S56R	RAX2_ENST00000555978.1_Missense_Mutation_p.S56R			Q96IS3	RAX2_HUMAN	retina and anterior neural fold homeobox 2			1		Hepatocellular(1079;0.137)			GCTCCTCACGGCTGTACACAT	0.627000																								0							SO:0001583	missense			ENST00000555633.1	0	1	hg19	CCDS12112.1	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	G|G	17.87|17.87	3.496105|3.496105	0.64186|0.64186	.|.	.|.	ENSG00000173976|ENSG00000173976	ENST00000555978|ENST00000555633;ENST00000395106	.|D	.|0.95035	.|-3.59	3.52|3.52	1.26|1.26	0.21427|0.21427	.|Homeodomain-related (1);Homeobox (3);Homeodomain-like (1);	.|0.000000	.|0.37304	.|U	.|0.002147	D|D	0.90259|0.90259	0.6954|0.6954	N|N	0.03194|0.03194	-0.395|-0.395	0.51233|0.51233	D|D	0.999912|0.999912	.|D;D	.|0.61697	.|0.99;0.958	.|D;P	.|0.66979	.|0.948;0.824	D|D	0.87913|0.87913	0.2698|0.2698	5|10	.|0.72032	.|D	.|0.01	.|.	6.8196|6.8196	0.23849|0.23849	0.3119:0.0:0.688:0.0|0.3119:0.0:0.688:0.0	.|.	.|56;102	.|Q96IS3;G3V243	.|RAX2_HUMAN;.	T|R	76|102;56	.|ENSP00000450456:S102R	.|ENSP00000378538:S56R	P|S	-|-	1|3	0|2	RAX2|RAX2	3722573|3722573	1.000000|1.000000	0.71417|0.71417	0.995000|0.995000	0.50966|0.50966	0.894000|0.894000	0.52154|0.52154	2.372000|2.372000	0.44257|0.44257	0.468000|0.468000	0.27243|0.27243	0.561000|0.561000	0.74099|0.74099	CCG|AGC		TCGA-2J-AABO-01A-21D-A40W-08	RAX2-001	PUTATIVE	alternative_5_UTR|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000411919.2	0	0	1	5	46	0	16		0	0	0	0	16	2		0	0	0	0	0	2	1	0.937634	5	45	0	16	2								-10.305420	1	1	0	0		1	1	2	3	1.851504	1	0.240000	3.570000	0.315562	0.980000	0.380000	1.000000	1.000000	0.860692	0.980000	1	6.300000e-01	1
PLIN4	729359	broad.mit.edu	37	19	4511956	4511956	+	Silent	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr19:4511956G>A	ENST00000301286.3	-	3	1973	c.1974C>T	c.(1972-1974)acC>acT	p.T658T		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4			41					TCACAGCACTGGTCACCCCAC	0.582000																								0							SO:0001819	synonymous_variant			ENST00000301286.3	1	1	hg19	CCDS45927.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	PLIN4-001	NOVEL	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000395095.1	1	0	1	70	590	0	223	0	0	0	1	0	223	2		0	0	0	0	0	2	1	1.000000	69	541	0	208	2								-2.806910	1	1	120898	5	45	1	1	2	3	1.851504	1	0.240000	3.570000	0.315562	0.990000	0.770000	1.000000	1.000000	0.953046	0.990000	1	8.700000e-01	1
SLC8A2	6543	broad.mit.edu	37	19	47969356	47969356	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr19:47969356G>A	ENST00000236877.6	-	2	700	c.305C>T	c.(304-306)tCa>tTa	p.S102L	SLC8A2_ENST00000542837.1_Intron|SLC8A2_ENST00000539381.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2			31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)			CTTCTCTTTTGACGTGATGAC	0.577000																								0							SO:0001583	missense			ENST00000236877.6	1	1	hg19	CCDS33065.1	.	.	.	.	.	.	.	.	.	.	G	20.8	4.048442	0.75846	.	.	ENSG00000118160	ENST00000236877	T	0.64438	-0.1	4.25	4.25	0.50352	Sodium/calcium exchanger membrane region (1);	0.000000	0.85682	D	0.000000	D	0.85191	0.5640	H	0.96080	3.765	0.80722	D	1	D	0.89917	1.0	D	0.87578	0.998	D	0.90331	0.4352	10	0.87932	D	0	.	15.6004	0.76620	0.0:0.0:1.0:0.0	.	102	Q9UPR5	NAC2_HUMAN	L	102	ENSP00000236877:S102L	ENSP00000236877:S102L	S	-	2	0	SLC8A2	52661168	1.000000	0.71417	0.828000	0.32881	0.520000	0.34377	9.587000	0.98229	2.210000	0.71456	0.462000	0.41574	TCA		TCGA-2J-AABO-01A-21D-A40W-08	SLC8A2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000466997.1	1	0	1	30	271	0	128	0	1.076950e-02	0	2	0	128	2		0	0	0	0	0	2	1	1.000000	29	264	0	126	2								-20.000000	1	1	0	0		1	1	2	3	1.868588	1	0.240000	3.570000	0.321429	0.930000	0.640000	1.000000	1.000000	0.905548	0.930000	1	7.800000e-01	1
SAFB	6294	broad.mit.edu	37	19	5654163	5654163	+	Missense_Mutation	SNP	G	G	A	rs11542075		TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr19:5654163G>A	ENST00000292123.5	+	12	1725	c.1618G>A	c.(1618-1620)Gat>Aat	p.D540N	SAFB_ENST00000588852.1_Missense_Mutation_p.D540N|SAFB_ENST00000592224.1_Missense_Mutation_p.D540N|SAFB_ENST00000538656.1_Missense_Mutation_p.D383N|SAFB_ENST00000433404.1_Missense_Mutation_p.D370N|SAFB_ENST00000454510.1_Missense_Mutation_p.D471N	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B			23					TAAGGACCAAGATGATCAGAA	0.463000													Colon(88;338 1345 6184 8214 20897)											0							SO:0001583	missense			ENST00000292123.5	1	1	hg19	CCDS12142.1	.	.	.	.	.	.	.	.	.	.	G	18.59	3.656306	0.67586	.	.	ENSG00000160633	ENST00000454510;ENST00000540206;ENST00000433404;ENST00000292123;ENST00000538656	T;T;T;T	0.12569	2.72;2.86;2.69;2.67	5.34	4.29	0.51040	.	0.103415	0.42682	D	0.000680	T	0.16128	0.0388	L	0.57536	1.79	0.44036	D	0.996762	B;P;B;B;B;B;B	0.37824	0.321;0.609;0.449;0.11;0.11;0.11;0.11	B;B;B;B;B;B;B	0.36885	0.101;0.235;0.205;0.074;0.119;0.074;0.119	T	0.01909	-1.1249	10	0.59425	D	0.04	-27.4843	13.4452	0.61136	0.0766:0.0:0.9234:0.0	.	339;383;471;540;540;540;540	B7Z1C7;B7Z2F6;F5H0H3;B7ZLP5;A0AV56;Q15424;B7ZLP6	.;.;.;.;.;SAFB1_HUMAN;.	N	471;435;370;540;383	ENSP00000415895:D471N;ENSP00000404545:D370N;ENSP00000292123:D540N;ENSP00000438880:D383N	ENSP00000292123:D540N	D	+	1	0	SAFB	5605163	0.966000	0.33281	0.886000	0.34754	0.994000	0.84299	3.458000	0.53014	2.654000	0.90174	0.563000	0.77884	GAT		TCGA-2J-AABO-01A-21D-A40W-08	SAFB-003	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000451641.2	1	0	0	31	288	0	56	1	9.981368e-01	16	76	0	56	2		0	0	0	0	0	2	1	1.000000	29	283	0	56	2								-11.677650	1	1	0	0		1	1	2	3	1.851504	1	0.240000	3.570000	0.315562	0.910000	0.630000	1.000000	1.000000	0.893844	0.910000	1	7.600000e-01	1
ZNF835	90485	broad.mit.edu	37	19	57175926	57175926	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr19:57175926C>T	ENST00000537055.2	-	2	872	c.641G>A	c.(640-642)cGc>cAc	p.R214H		NM_001005850.2	NP_001005850.2	Q9Y2P0	ZN835_HUMAN	zinc finger protein 835			47					CGTGTGCACGCGCCGGTGCTG	0.721000																								0							SO:0001583	missense			ENST00000537055.2	0	1	hg19	CCDS56105.1	.	.	.	.	.	.	.	.	.	.	C	19.11	3.763428	0.69763	.	.	ENSG00000127903	ENST00000342088;ENST00000537055	T	0.25749	1.78	2.12	2.12	0.27331	Zinc finger, C2H2-like (1);Zinc finger, C2H2 (3);Zinc finger, C2H2-type/integrase, DNA-binding (1);	.	.	.	.	T	0.49253	0.1546	M	0.76838	2.35	0.09310	N	1	D	0.89917	1.0	D	0.87578	0.998	T	0.21314	-1.0249	9	0.87932	D	0	.	10.2869	0.43573	0.0:1.0:0.0:0.0	.	236	Q9Y2P0	ZN835_HUMAN	H	236;214	ENSP00000444747:R214H	ENSP00000341756:R236H	R	-	2	0	ZNF835	61867738	0.000000	0.05858	0.049000	0.19019	0.502000	0.33828	-0.055000	0.11807	1.506000	0.48736	0.561000	0.74099	CGC		TCGA-2J-AABO-01A-21D-A40W-08	ZNF835-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000459800.1	0	0	0	5	70	0	24		0	0	0	0	24	2		0	0	0	0	0	2	1	0.939746	5	70	0	23	2								-10.081120	1	1	0	0		1	1	2	3	1.895001	1	0.240000	3.570000	0.321429	0.660000	0.260000	1.000000	1.000000	0.679957	0.660000	0	4.300000e-01	9.700000e-01
ZNF256	10172	broad.mit.edu	37	19	58453978	58453978	+	Silent	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr19:58453978C>T	ENST00000282308.3	-	3	394	c.198G>A	c.(196-198)caG>caA	p.Q66Q	ZNF256_ENST00000598928.1_Missense_Mutation_p.S24N	NM_005773.2	NP_005764.2	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256			19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)			AAGTGCTCTGCTGATAAGGTG	0.532000													NSCLC(55;1313 1552 8040 11996)											0							SO:0001819	synonymous_variant			ENST00000282308.3	0	1	hg19	CCDS12966.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	ZNF256-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000466702.1	0	0	1	151	432	1	120	0	6.737823e-02	0	2	1	120	2		0	0	0	0	0	2	1	1.000000	150	427	1	117	17								-20.000000	1	1	0	0		1	1	2	3	1.895001	1	0.240000	3.570000	0.321429	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
OR7D2	162998	broad.mit.edu	37	19	9296718	9296718	+	Silent	SNP	C	C	T	rs139213903		TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr19:9296718C>T	ENST00000344248.2	+	1	440	c.261C>T	c.(259-261)acC>acT	p.T87T		NM_175883.2	NP_787079.1	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D, member 2			20					ACATCCAGACCGAGAACAAAG	0.507000																								0							SO:0001819	synonymous_variant			ENST00000344248.2	0	1	hg19	CCDS32900.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	OR7D2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000449002.1	0	0	0	5	512	0	117		0	0	0	0	117	2		0	0	0	0	0	2	1	0.935232	5	504	0	117	2								-2.027508	0	1	121412	2	35	1	1	2	3	1.856169	1	0.240000	3.570000	0.321429	0.090000	0.020000	0.200000	0.090000	0.107439	0.090000	0	5.000000e-02	1.500000e-01
S1PR1	1901	broad.mit.edu	37	1	101705312	101705312	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr1:101705312G>A	ENST00000305352.6	+	2	1147	c.772G>A	c.(772-774)Gta>Ata	p.V258I		NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1			43					GCTCAAGACCGTAATTATCGT	0.587000																								0							SO:0001583	missense			ENST00000305352.6	0	1	hg19	CCDS777.1	.	.	.	.	.	.	.	.	.	.	G	25.4	4.632336	0.87660	.	.	ENSG00000170989	ENST00000305352;ENST00000424264	T	0.36878	1.23	5.22	5.22	0.72569	GPCR, rhodopsin-like superfamily (1);	0.000000	0.85682	D	0.000000	T	0.51363	0.1670	L	0.59436	1.845	0.80722	D	1	D	0.89917	1.0	D	0.76071	0.987	T	0.55186	-0.8180	10	0.87932	D	0	.	18.848	0.92215	0.0:0.0:1.0:0.0	.	258	P21453	S1PR1_HUMAN	I	258	ENSP00000305416:V258I	ENSP00000305416:V258I	V	+	1	0	S1PR1	101477900	1.000000	0.71417	0.688000	0.30117	0.831000	0.47069	9.869000	0.99810	2.438000	0.82558	0.449000	0.29647	GTA		TCGA-2J-AABO-01A-21D-A40W-08	S1PR1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000029908.1	0	0	0	5	560	0	135	0	2.506318e-02	0	22	0	135	2		0	0	0	0	0	2	1	0.936324	5	555	0	135	2								-2.547949	1	1	0	0		1	1	2	3	1.912430	0	0.240000	3.570000	0.321429	0.080000	0.020000	0.180000	0.090000	0.098356	0.080000	0	5.000000e-02	1.400000e-01
KCND3	3752	broad.mit.edu	37	1	112525004	112525004	+	Silent	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr1:112525004G>A	ENST00000315987.2	-	2	824	c.345C>T	c.(343-345)gaC>gaT	p.D115D	KCND3_ENST00000302127.4_Silent_p.D115D|KCND3_ENST00000369697.1_Silent_p.D115D	NM_004980.4	NP_004971.2	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3			49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		Amitriptyline(DB00321)|Dalfampridine(DB06637)|Disopyramide(DB00280)|Imipramine(DB00458)	CCAGCTCGTCGTCGTAGGCAG	0.627000																								0							SO:0001819	synonymous_variant			ENST00000315987.2	1	1	hg19	CCDS843.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	KCND3-001	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000033144.1	1	0	0	30	275	0	67	0	0	0	1	0	67	2		0	0	0	0	0	2	1	1.000000	29	269	0	67	2								-20.000000	1	1	0	0		1	1	2	3	1.912430	0	0.240000	3.570000	0.321429	0.920000	0.640000	1.000000	1.000000	0.898221	0.920000	1	7.700000e-01	1
TRIM33	51592	broad.mit.edu	37	1	114968220	114968220	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr1:114968220G>T	ENST00000358465.2	-	9	1629	c.1546C>A	c.(1546-1548)Ctc>Atc	p.L516I	TRIM33_ENST00000369543.2_Missense_Mutation_p.L516I|TRIM33_ENST00000450349.2_Missense_Mutation_p.L124I	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33			48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)			ATGTGCTGGAGTCGAAGCTGT	0.458000			T	RET	papillary thyroid										Dom	yes		1	1p13	51592	tripartite motif-containing 33 (PTC7,TIF1G)		E	0							SO:0001583	missense			ENST00000358465.2	1	1	hg19	CCDS872.1	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	G|G	24.4|24.4	4.521938|4.521938	0.85600|0.85600	.|.	.|.	ENSG00000197323|ENSG00000197323	ENST00000448034|ENST00000358465;ENST00000369543;ENST00000450349	.|T;T;T	.|0.77358	.|-0.89;-0.8;-1.09	5.13|5.13	5.13|5.13	0.70059|0.70059	.|.	.|0.000000	.|0.85682	.|D	.|0.000000	D|D	0.82861|0.82861	0.5129|0.5129	L|L	0.50333|0.50333	1.59|1.59	0.80722|0.80722	D|D	1|1	.|D;D;D;B	.|0.67145	.|0.982;0.982;0.996;0.434	.|D;D;D;B	.|0.75484	.|0.952;0.952;0.986;0.417	T|T	0.82466|0.82466	-0.0443|-0.0443	5|10	.|0.48119	.|T	.|0.1	-8.1052|-8.1052	18.9585|18.9585	0.92670|0.92670	0.0:0.0:1.0:0.0|0.0:0.0:1.0:0.0	.|.	.|124;124;516;516	.|E7EN20;B3KN30;Q9UPN9-2;Q9UPN9	.|.;.;.;TRI33_HUMAN	E|I	252|516;516;124	.|ENSP00000351250:L516I;ENSP00000358556:L516I;ENSP00000412077:L124I	.|ENSP00000351250:L516I	D|L	-|-	3|1	2|0	TRIM33|TRIM33	114769743|114769743	1.000000|1.000000	0.71417|0.71417	1.000000|1.000000	0.80357|0.80357	0.977000|0.977000	0.68977|0.68977	7.114000|7.114000	0.77103|0.77103	2.554000|2.554000	0.86153|0.86153	0.650000|0.650000	0.86243|0.86243	GAC|CTC		TCGA-2J-AABO-01A-21D-A40W-08	TRIM33-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000032854.1	1	0	1	106	932	0	245	0	5.546424e-02	0	4	0	245	2		0	0	0	0	0	2	1	1.000000	106	916	0	236	2								-20.000000	1	1	0	0		1						0.240000	3.570000									0	0
SYCP1	6847	broad.mit.edu	37	1	115417138	115417138	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr1:115417138C>T	ENST00000369522.3	+	9	850	c.610C>T	c.(610-612)Cgg>Tgg	p.R204W	SYCP1_ENST00000369518.1_Missense_Mutation_p.R204W	NM_001282541.1|NM_003176.2	NP_001269470.1|NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	p.R204W(1)	RGS22/SYCP1(2)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)			TGAATATGAACGGGAAGAAAC	0.264000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000369522.3	1	1	hg19	CCDS879.1	.	.	.	.	.	.	.	.	.	.	C	18.76	3.693727	0.68386	.	.	ENSG00000198765	ENST00000369522;ENST00000536734;ENST00000455987;ENST00000369518	T;T;T	0.58060	0.36;0.36;0.36	5.13	4.09	0.47781	.	0.000000	0.85682	D	0.000000	T	0.61590	0.2359	M	0.72894	2.215	0.46954	D	0.99926	D;D	0.89917	1.0;1.0	D;D	0.91635	0.999;0.999	T	0.64968	-0.6282	10	0.87932	D	0	-5.1042	9.5872	0.39524	0.2601:0.7399:0.0:0.0	.	204;204	B7ZLS9;Q15431	.;SYCP1_HUMAN	W	204	ENSP00000358535:R204W;ENSP00000410011:R204W;ENSP00000358531:R204W	ENSP00000358531:R204W	R	+	1	2	SYCP1	115218661	1.000000	0.71417	1.000000	0.80357	0.951000	0.60555	3.147000	0.50639	2.564000	0.86499	0.655000	0.94253	CGG		TCGA-2J-AABO-01A-21D-A40W-08	SYCP1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000033386.1	1	0	0	59	671	1	111		0	0	0	1	111	2		0	0	0	0	0	2	1	0.999994	59	667	1	108	22								-13.351380	1	1	0	0		1						0.240000	3.570000									0	0
PUSL1	126789	broad.mit.edu	37	1	1244928	1244928	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr1:1244928C>T	ENST00000379031.5	+	4	495	c.418C>T	c.(418-420)Cgg>Tgg	p.R140W	PUSL1_ENST00000470520.1_3'UTR|ACAP3_ENST00000354700.5_5'Flank|CPSF3L_ENST00000462432.1_5'Flank|ACAP3_ENST00000353662.3_5'Flank	NM_153339.1	NP_699170.1	Q8N0Z8	PUSL1_HUMAN	pseudouridylate synthase-like 1			5	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)			TGGCTGTCACCGGCGTGATGA	0.687000																								0							SO:0001583	missense			ENST00000379031.5	1	1	hg19	CCDS20.1	.	.	.	.	.	.	.	.	.	.	c	5.473	0.272323	0.10349	.	.	ENSG00000169972	ENST00000379031	T	0.58358	0.34	4.49	-8.47	0.00939	Pseudouridine synthase I, TruA, C-terminal (1);Pseudouridine synthase, catalytic domain (1);	1.673000	0.04521	U	0.384611	T	0.38585	0.1046	L	0.56769	1.78	0.09310	N	1	B	0.13594	0.008	B	0.04013	0.001	T	0.26849	-1.0091	10	0.46703	T	0.11	-0.6521	0.5893	0.00725	0.2258:0.1719:0.3063:0.296	.	140	Q8N0Z8	PUSL1_HUMAN	W	140	ENSP00000368318:R140W	ENSP00000368318:R140W	R	+	1	2	PUSL1	1234791	0.000000	0.05858	0.000000	0.03702	0.008000	0.06430	-1.823000	0.01710	-1.684000	0.01443	-0.389000	0.06534	CGG		TCGA-2J-AABO-01A-21D-A40W-08	PUSL1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000009438.1	1	0	0	13	80	0	23	1	7.657000e-01	2	17	0	23	2		0	0	0	0	0	2	1	0.999584	13	77	0	23	2								-19.993450	1	1	0	0		1	1	2	3	1.938390	0	0.240000	3.570000	0.321429	0.990000	0.760000	1.000000	1.000000	0.980657	0.990000	1	9.900000e-01	1
RPTN	126638	broad.mit.edu	37	1	152127241	152127241	+	Silent	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr1:152127241G>A	ENST00000316073.3	-	3	2398	c.2334C>T	c.(2332-2334)gaC>gaT	p.D778D		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin			59					GGTTCTGCTCGTCTTCATGGG	0.463000																								0							SO:0001819	synonymous_variant			ENST00000316073.3	1	0	hg19	CCDS41397.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	RPTN-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000333867.1	1	0	1	348	1452	1	321	0	0	1	0	1	321	2		0	0	0	0	0	2	1	1.000000	340	1427	0	312	2								-20.000000	1	1	120612	18	49	1	2	2	4	2.065498	0	0.240000	3.570000	0.382315	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
SMCP	4184	broad.mit.edu	37	1	152857174	152857174	+	Silent	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr1:152857174G>A	ENST00000368765.3	+	2	426	c.276G>A	c.(274-276)ccG>ccA	p.P92P		NM_030663.2	NP_109588.2	P49901	MCSP_HUMAN	sperm mitochondria-associated cysteine-rich protein	p.P92P(1)		8	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)		CCAACTCACCGCAAACTCAGG	0.537000																								1	Substitution - coding silent(1)						SO:0001819	synonymous_variant			ENST00000368765.3	0	1	hg19	CCDS1029.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	SMCP-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000034665.1	0	0	0	6	528	0	65		0	0	0	0	65	2		0	0	0	0	0	2	1	0.964535	6	525	0	64	2								-1.868207	0	1	0	0		1	2	2	4	2.065498	0	0.240000	3.570000	0.382315	0.120000	0.040000	1.000000	0.120000	0.158486	0.120000	0	7.000000e-02	1.900000e-01
FCGR2B	2213	broad.mit.edu	37	1	161643018	161643018	+	Splice_Site	SNP	A	A	G			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr1:161643018A>G	ENST00000358671.5	+	4	726	c.645A>G	c.(643-645)caA>caG	p.Q215Q	RP11-25K21.1_ENST00000453111.1_RNA|FCGR2B_ENST00000403078.3_Splice_Site_p.Q215Q|FCGR2B_ENST00000367961.4_Splice_Site_p.Q208Q|FCGR2B_ENST00000236937.9_Splice_Site_p.Q215Q|FCGR2B_ENST00000367960.5_Splice_Site_p.Q208Q|FCGR2B_ENST00000367962.4_Splice_Site_p.Q215Q|FCGR2B_ENST00000428605.2_Splice_Site_p.Q215Q	NM_001002275.2|NM_004001.4	NP_001002275.1|NP_003992.3	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor (CD32)				all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Antithymocyte globulin(DB00098)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Intravenous Immunoglobulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCACTGTCCAAGGTATGCGGA	0.542000			T	?	ALL										Dom	yes		1	1q23	2213	Fc fragment of IgG, low affinity IIb, receptor for (CD32)		L	0							SO:0001630	splice_region_variant			ENST00000358671.5	1	0	hg19	CCDS30924.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	FCGR2B-002	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000083337.4	0	0	1	22	146	0	36		0	0	0	0	36	2		0	0	0	0	0	2	1	0.999998	21	133	0	50	2								-11.862960	1	1	0	0		1	2	2	4	2.065498	0	0.240000	3.570000	0.382315	0.990000	0.890000	1.000000	1.000000	0.993654	0.990000	1	9.900000e-01	1
ZNF496	84838	broad.mit.edu	37	1	247464376	247464376	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr1:247464376C>A	ENST00000294753.4	-	9	1673	c.1209G>T	c.(1207-1209)aaG>aaT	p.K403N	ZNF496_ENST00000462139.1_5'UTR|ZNF496_ENST00000366498.2_Missense_Mutation_p.K439N	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496			36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)		CGTAGGACTTCTTGGAGGTCT	0.642000																								0							SO:0001583	missense			ENST00000294753.4	1	1	hg19	CCDS1631.1	.	.	.	.	.	.	.	.	.	.	C	14.20	2.465499	0.43839	.	.	ENSG00000162714	ENST00000294753;ENST00000366498	T;T	0.45276	0.9;0.9	4.65	-4.52	0.03472	Zinc finger, C2H2-type/integrase, DNA-binding (1);	1.008270	0.07967	N	0.983345	T	0.24353	0.0590	N	0.19112	0.55	0.09310	N	0.999996	P;P	0.37276	0.589;0.454	B;B	0.36608	0.229;0.037	T	0.25012	-1.0144	10	0.59425	D	0.04	-7.8109	6.9593	0.24587	0.0:0.3763:0.1183:0.5054	.	439;403	Q96IT1-2;Q96IT1	.;ZN496_HUMAN	N	403;439	ENSP00000294753:K403N;ENSP00000355454:K439N	ENSP00000294753:K403N	K	-	3	2	ZNF496	245530999	0.001000	0.12720	0.003000	0.11579	0.217000	0.24651	-0.786000	0.04623	-1.039000	0.03275	-0.140000	0.14226	AAG		TCGA-2J-AABO-01A-21D-A40W-08	ZNF496-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000098655.2	0	0	0	10	266	0	53	0	4.937993e-02	0	9	0	53	2		0	0	0	0	0	2	1	0.996857	11	262	0	51	2								-11.555700	1	1	0	0		1	2	2	4	2.086598	0	0.240000	3.570000	0.387097	0.380000	0.190000	0.650000	0.360000	0.406539	0.380000	0	2.800000e-01	5.200000e-01
ZFYVE9	9372	broad.mit.edu	37	1	52747411	52747411	+	Missense_Mutation	SNP	A	A	C			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr1:52747411A>C	ENST00000371591.1	+	9	3079	c.2948A>C	c.(2947-2949)cAg>cCg	p.Q983P	ZFYVE9_ENST00000287727.3_Missense_Mutation_p.Q983P|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.Q924P	NM_004799.2|NM_007324.2	NP_004790.2|NP_015563.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9			53					ATTCTTCTACAGTGTTTACCG	0.418000																								0							SO:0001583	missense			ENST00000371591.1	0	1	hg19	CCDS563.1	.	.	.	.	.	.	.	.	.	.	A	24.7	4.563599	0.86335	.	.	ENSG00000157077	ENST00000357206;ENST00000287727;ENST00000371591	T;T;T	0.58210	0.35;0.35;0.35	4.93	4.93	0.64822	.	0.000000	0.64402	D	0.000001	T	0.65554	0.2702	L	0.55481	1.735	0.80722	D	1	D;D	0.71674	0.998;0.989	P;D	0.63957	0.849;0.92	T	0.67711	-0.5600	10	0.54805	T	0.06	.	14.7338	0.69402	1.0:0.0:0.0:0.0	.	924;983	O95405-2;O95405	.;ZFYV9_HUMAN	P	924;983;983	ENSP00000349737:Q924P;ENSP00000287727:Q983P;ENSP00000360647:Q983P	ENSP00000287727:Q983P	Q	+	2	0	ZFYVE9	52519999	1.000000	0.71417	0.969000	0.41365	0.977000	0.68977	9.009000	0.93606	2.062000	0.61559	0.482000	0.46254	CAG		TCGA-2J-AABO-01A-21D-A40W-08	ZFYVE9-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000022083.1	0	0	0	6	591	0	139	0	4.612468e-04	0	3	0	139	2		0	0	0	0	0	2	1	0.964008	6	586	0	137	2								-3.313857	1	1	0	0		1	1	2	3	1.912430	0	0.240000	3.570000	0.321429	0.090000	0.030000	0.200000	0.090000	0.108705	0.090000	0	6.000000e-02	1.500000e-01
RALGAPA2	57186	broad.mit.edu	37	20	20563724	20563724	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr20:20563724G>T	ENST00000202677.7	-	20	2684	c.2677C>A	c.(2677-2679)Ctg>Atg	p.L893M		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)			54					GTGGGACTCAGTTGTAACCAA	0.468000																								0							SO:0001583	missense			ENST00000202677.7	1	1	hg19	CCDS46584.1	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	G|G	14.96|14.96	2.691060|2.691060	0.48097|0.48097	.|.	.|.	ENSG00000188559|ENSG00000188559	ENST00000202677|ENST00000430436	T|.	0.70164|.	-0.46|.	6.07|6.07	4.13|4.13	0.48395|0.48395	.|.	0.000000|.	0.64402|.	D|.	0.000001|.	T|T	0.67135|0.67135	0.2861|0.2861	M|M	0.76328|0.76328	2.33|2.33	0.36785|0.36785	D|D	0.884564|0.884564	D;D|.	0.89917|.	1.0;0.998|.	D;D|.	0.71184|.	0.972;0.931|.	T|T	0.73257|0.73257	-0.4040|-0.4040	10|5	0.40728|.	T|.	0.16|.	.|.	10.5141|10.5141	0.44879|0.44879	0.2044:0.0:0.7956:0.0|0.2044:0.0:0.7956:0.0	.|.	731;893|.	A8MSM5;Q2PPJ7|.	.;RGPA2_HUMAN|.	M|K	893|709	ENSP00000202677:L893M|.	ENSP00000202677:L893M|.	L|N	-|-	1|3	2|2	RALGAPA2|RALGAPA2	20511724|20511724	0.961000|0.961000	0.32948|0.32948	0.992000|0.992000	0.48379|0.48379	0.608000|0.608000	0.37181|0.37181	1.380000|1.380000	0.34351|0.34351	1.581000|1.581000	0.49865|0.49865	0.655000|0.655000	0.94253|0.94253	CTG|AAC		TCGA-2J-AABO-01A-21D-A40W-08	RALGAPA2-008	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000471941.1	0	0	0	7	253	0	53	0	1.933877e-02	0	7	0	53	2		0	0	0	0	0	2	1	0.980198	7	250	0	53	2								-8.237756	1	1	0	0		1	2	2	4	2.038962	0	0.240000	3.570000	0.375000	0.300000	0.120000	1.000000	0.270000	0.363467	0.300000	0	2.000000e-01	4.600000e-01
SIGLEC1	6614	broad.mit.edu	37	20	3674202	3674202	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr20:3674202T>C	ENST00000344754.4	-	13	3399	c.3400A>G	c.(3400-3402)Atc>Gtc	p.I1134V	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.I1134V	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin			70					GGCAGGGGGATGGAGTGGGCA	0.657000																								0							SO:0001583	missense			ENST00000344754.4	0	1	hg19	CCDS13060.1	.	.	.	.	.	.	.	.	.	.	T	5.206	0.223588	0.09863	.	.	ENSG00000088827	ENST00000344754;ENST00000202578	T;T	0.11712	2.75;2.75	5.52	3.08	0.35506	Immunoglobulin subtype (1);Immunoglobulin-like (1);Immunoglobulin (1);Immunoglobulin-like fold (1);	0.000000	0.42548	D	0.000692	T	0.09024	0.0223	L	0.35542	1.07	0.24899	N	0.992116	B;B	0.19935	0.04;0.014	B;B	0.24974	0.057;0.027	T	0.22695	-1.0209	10	0.45353	T	0.12	.	9.2318	0.37441	0.0:0.0:0.3576:0.6424	.	1134;1134	Q9BZZ2;Q9BZZ2-3	SN_HUMAN;.	V	1134	ENSP00000341141:I1134V;ENSP00000202578:I1134V	ENSP00000202578:I1134V	I	-	1	0	SIGLEC1	3622202	1.000000	0.71417	0.930000	0.37139	0.011000	0.07611	0.477000	0.22196	0.915000	0.36847	0.533000	0.62120	ATC		TCGA-2J-AABO-01A-21D-A40W-08	SIGLEC1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000077761.2	1	0	1	12	117	0	23		0	0	0	0	23	2	0	0	1	0	0	0	2	1	0.999267	12	117	0	23	2								-18.524400	1	1	121396	4	32	1	2	2	4	2.038962	0	0.240000	3.570000	0.375000	0.990000	0.540000	1.000000	1.000000	0.901161	0.990000	1	7.400000e-01	1
RIMS4	140730	broad.mit.edu	37	20	43384834	43384834	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr20:43384834G>A	ENST00000372851.3	-	6	817	c.751C>T	c.(751-753)Cgg>Tgg	p.R251W	RIMS4_ENST00000541604.2_Missense_Mutation_p.R252W	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4			29		Myeloproliferative disorder(115;0.0122)			GATGCCTGCCGGAGCAGGGGG	0.662000																								0							SO:0001583	missense			ENST00000372851.3	1	1	hg19	CCDS13338.1	.	.	.	.	.	.	.	.	.	.	G	20.8	4.044559	0.75732	.	.	ENSG00000101098	ENST00000372851;ENST00000541604	T;T	0.24151	1.87;1.87	4.95	4.95	0.65309	.	0.000000	0.85682	D	0.000000	T	0.46521	0.1397	L	0.60067	1.865	0.80722	D	1	D;D	0.89917	1.0;1.0	D;D	0.85130	0.997;0.997	T	0.44802	-0.9304	10	0.87932	D	0	.	13.2074	0.59805	0.0:0.0:0.8409:0.1591	.	252;251	E1P613;Q9H426	.;RIMS4_HUMAN	W	251;252	ENSP00000361942:R251W;ENSP00000439287:R252W	ENSP00000361942:R251W	R	-	1	2	RIMS4	42818248	1.000000	0.71417	1.000000	0.80357	0.993000	0.82548	5.563000	0.67352	2.285000	0.76669	0.563000	0.77884	CGG		TCGA-2J-AABO-01A-21D-A40W-08	RIMS4-002	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000101027.2	1	0	1	98	316	0	82		0	0	0	0	82	2		0	0	0	0	0	2	1	1.000000	97	310	0	81	2								-4.180830	1	1	0	0		1	2	2	4	2.038962	0	0.240000	3.570000	0.375000	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
DOPEY2	9980	broad.mit.edu	37	21	37661466	37661466	+	Silent	SNP	G	G	A	rs112991413	byFrequency	TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr21:37661466G>A	ENST00000399151.3	+	35	6562	c.6477G>A	c.(6475-6477)gcG>gcA	p.A2159A		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2			58					TGGACACAGCGCTTTCTTTTC	0.413000																								0							SO:0001819	synonymous_variant			ENST00000399151.3	1	0	hg19	CCDS13643.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	DOPEY2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000194636.1	1	0	1	46	421	0	137	1	7.772314e-01	9	19	0	137	2		0	0	0	0	0	2	1	1.000000	46	416	0	135	2								-3.318794	1	1	121412	194	55	1	1	2	3	1.858815	1	0.240000	3.570000	0.316301	0.920000	0.680000	1.000000	1.000000	0.906684	0.920000	1	7.900000e-01	1
DSCR4	10281	broad.mit.edu	37	21	39492431	39492431	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr21:39492431G>A	ENST00000328264.3	-	2	304	c.200C>T	c.(199-201)aCg>aTg	p.T67M	DSCR4_ENST00000398948.1_Missense_Mutation_p.T67M|DSCR8_ENST00000400477.3_5'Flank|DSCR8_ENST00000357704.4_5'Flank	NM_005867.2	NP_005858.1	P56555	DSCR4_HUMAN	Down syndrome critical region gene 4			6					tccagaatccgtaggagaagc	0.363000																								0							SO:0001583	missense			ENST00000328264.3	1	1	hg19	CCDS33554.1	.	.	.	.	.	.	.	.	.	.	G	7.406	0.633692	0.14322	.	.	ENSG00000184029	ENST00000398948;ENST00000328264	.	.	.	1.45	-2.03	0.07365	.	.	.	.	.	T	0.18882	0.0453	.	.	.	0.09310	N	1	D	0.63880	0.993	B	0.41860	0.368	T	0.13602	-1.0503	7	0.87932	D	0	.	0.4825	0.00550	0.1868:0.246:0.3187:0.2485	.	67	P56555	DSCR4_HUMAN	M	67	.	ENSP00000328676:T67M	T	-	2	0	DSCR4	38414301	0.000000	0.05858	0.000000	0.03702	0.270000	0.26580	0.033000	0.13754	-0.677000	0.05231	0.313000	0.20887	ACG		TCGA-2J-AABO-01A-21D-A40W-08	DSCR4-001	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000194834.1	0	0	0	11	296	0	51		0	0	0	0	51	2		0	0	0	0	0	2	1	0.998354	11	294	0	50	2								-3.804006	1	1	0	0		1	1	2	3	1.858815	1	0.240000	3.570000	0.316301	0.350000	0.180000	1.000000	0.320000	0.393051	0.350000	0	2.500000e-01	4.800000e-01
DSCAM	1826	broad.mit.edu	37	21	41447025	41447025	+	Silent	SNP	C	C	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr21:41447025C>A	ENST00000400454.1	-	27	5304	c.4827G>T	c.(4825-4827)ctG>ctT	p.L1609L		NM_001271534.1|NM_001389.3	NP_001258463.1|NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule			142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)			GGAGCACAAACAGCAGCAAGA	0.592000													Melanoma(134;970 1778 1785 21664 32388)											0							SO:0001819	synonymous_variant			ENST00000400454.1	1	1	hg19	CCDS42929.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	DSCAM-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000195029.1	1	0	0	12	170	0	39	0	0	0	1	0	39	2		0	0	0	0	0	2	1	0.999161	12	168	0	39	2								-5.741892	1	1	0	0		1	1	2	3	1.858815	1	0.240000	3.570000	0.316301	0.640000	0.340000	1.000000	1.000000	0.663723	0.640000	0	4.700000e-01	8.600000e-01
MYO18B	84700	broad.mit.edu	37	22	26165019	26165019	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr22:26165019G>A	ENST00000407587.2	+	4	1305	c.1136G>A	c.(1135-1137)cGg>cAg	p.R379Q	MYO18B_ENST00000335473.7_Missense_Mutation_p.R379Q|MYO18B_ENST00000536101.1_Missense_Mutation_p.R379Q			Q8IUG5	MY18B_HUMAN	myosin XVIIIB			146					GGTGAGCTTCGGAGCACGACT	0.577000																								0							SO:0001583	missense			ENST00000407587.2	0	1	hg19		.	.	.	.	.	.	.	.	.	.	g	0.011	-1.725392	0.00694	.	.	ENSG00000133454	ENST00000536101;ENST00000335473;ENST00000407587	D;D;D	0.85955	-2.03;-2.03;-2.05	3.61	-7.22	0.01485	.	1.993940	0.02842	N	0.128040	T	0.58736	0.2143	N	0.02539	-0.55	0.09310	N	1	B;B;B	0.02656	0.0;0.0;0.0	B;B;B	0.01281	0.0;0.0;0.0	T	0.57406	-0.7817	10	0.22109	T	0.4	.	0.8732	0.01218	0.2243:0.3074:0.2432:0.2251	.	379;379;379	Q8IUG5;F5GXR6;F5GYU7	MY18B_HUMAN;.;.	Q	379	ENSP00000441229:R379Q;ENSP00000334563:R379Q;ENSP00000386096:R379Q	ENSP00000334563:R379Q	R	+	2	0	MYO18B	24495019	0.000000	0.05858	0.000000	0.03702	0.000000	0.00434	-4.457000	0.00231	-2.713000	0.00392	-2.582000	0.00168	CGG		TCGA-2J-AABO-01A-21D-A40W-08	MYO18B-006	NOVEL	non_canonical_conserved|basic|appris_candidate_longest|exp_conf	protein_coding	protein_coding	OTTHUMT00000400691.1	1	0	1	11	71	0	18		0	0	0	0	18	2		0	0	0	0	0	2	1	0.998725	11	71	0	17	2								-18.763630	1	1	121076	1	21	1	1	2	3	1.904117	0	0.240000	3.570000	0.321429	0.990000	0.690000	1.000000	1.000000	0.970008	0.990000	1	9.500000e-01	1
APOL5	80831	broad.mit.edu	37	22	36122258	36122258	+	Splice_Site	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr22:36122258C>T	ENST00000249044.2	+	3	143	c.143C>T	c.(142-144)cCc>cTc	p.P48L		NM_030642.1	NP_085145.1	Q9BWW9	APOL5_HUMAN	apolipoprotein L, 5			19					ATGTCTTTAGCCTCACTCGTG	0.443000																								0							SO:0001630	splice_region_variant			ENST00000249044.2	1	0	hg19	CCDS13920.1	.	.	.	.	.	.	.	.	.	.	C	11.99	1.803589	0.31869	.	.	ENSG00000128313	ENST00000249044	T	0.04049	3.72	2.15	-4.31	0.03698	.	4.487750	0.01131	U	0.005995	T	0.02455	0.0075	N	0.08118	0	0.09310	N	1	B	0.15473	0.013	B	0.06405	0.002	T	0.40534	-0.9558	9	.	.	.	.	4.0884	0.09958	0.0:0.2062:0.369:0.4248	.	48	Q9BWW9	APOL5_HUMAN	L	48	ENSP00000249044:P48L	.	P	+	2	0	APOL5	34452204	0.000000	0.05858	0.000000	0.03702	0.000000	0.00434	-1.097000	0.03349	-1.277000	0.02411	-0.731000	0.03576	CCC		TCGA-2J-AABO-01A-21D-A40W-08	APOL5-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000318979.1	1	0	0	24	240	0	48		0	0	0	0	48	2		0	0	0	0	0	2	1	1.000000	24	239	0	45	2								-3.318794	1	1	0	0		1	1	2	3	1.904117	0	0.240000	3.570000	0.321429	0.850000	0.560000	1.000000	1.000000	0.847716	0.850000	1	6.900000e-01	1
EP300	2033	broad.mit.edu	37	22	41542773	41542773	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr22:41542773G>A	ENST00000263253.7	+	11	3303	c.2084G>A	c.(2083-2085)cGt>cAt	p.R695H		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300			171					AGTATGATCCGTGGCAGTGTG	0.393000			T,  N, F, Mis, O	MLL, RUNXBP2	colorectal, breast, pancreatic, AML, ALL, DLBCL				Rubinstein-Taybi syndrome						Rec	yes		22	22q13	2033	300 kd E1A-Binding protein gene		L, E	0							SO:0001583	missense	Familial Cancer Database	Broad Thumb-Hallux syndrome	ENST00000263253.7	1	1	hg19	CCDS14010.1	.	.	.	.	.	.	.	.	.	.	G	35	5.538907	0.96474	.	.	ENSG00000100393	ENST00000263253	D	0.83914	-1.78	5.77	5.77	0.91146	.	0.132950	0.34178	N	0.004196	D	0.85703	0.5758	N	0.24115	0.695	0.58432	D	0.999998	D	0.76494	0.999	D	0.71656	0.974	D	0.84199	0.0449	10	0.33141	T	0.24	-2.4217	19.9922	0.97370	0.0:0.0:1.0:0.0	.	695	Q09472	EP300_HUMAN	H	695	ENSP00000263253:R695H	ENSP00000263253:R695H	R	+	2	0	EP300	39872719	1.000000	0.71417	1.000000	0.80357	0.989000	0.77384	8.683000	0.91236	2.729000	0.93468	0.563000	0.77884	CGT		TCGA-2J-AABO-01A-21D-A40W-08	EP300-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000320600.1	1	0	0	29	628	0	67	0	1.327913e-01	0	14	0	67	2		0	0	0	0	0	2	1	1.000000	29	621	0	65	2								-3.313220	1	1	0	0		1	1	10	11	3.375024	1	0.240000	3.570000	0.620834	0.750000	0.490000	1.000000	1.000000	0.769527	0.750000	0	6.100000e-01	9.400000e-01
LCT	3938	broad.mit.edu	37	2	136567237	136567237	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr2:136567237C>T	ENST00000264162.2	-	8	2690	c.2680G>A	c.(2680-2682)Gaa>Aaa	p.E894K	Y_RNA_ENST00000363794.1_RNA	NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase			124				Vitamin C(DB00126)	AAATCTCTTTCGAACTTGGGT	0.517000																								0							SO:0001583	missense			ENST00000264162.2	1	1	hg19	CCDS2178.1	.	.	.	.	.	.	.	.	.	.	C	19.54	3.847176	0.71603	.	.	ENSG00000115850	ENST00000264162;ENST00000455227	T	0.29917	1.55	5.78	5.78	0.91487	.	0.148918	0.64402	D	0.000012	T	0.59032	0.2164	M	0.78049	2.395	0.51767	D	0.999935	D	0.67145	0.996	D	0.67231	0.95	T	0.61113	-0.7128	10	0.72032	D	0.01	-28.1342	20.0139	0.97470	0.0:1.0:0.0:0.0	.	894	P09848	LPH_HUMAN	K	894;326	ENSP00000264162:E894K	ENSP00000264162:E894K	E	-	1	0	LCT	136283707	0.995000	0.38212	1.000000	0.80357	0.647000	0.38526	1.529000	0.35996	2.724000	0.93272	0.563000	0.77884	GAA		TCGA-2J-AABO-01A-21D-A40W-08	LCT-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000254657.1	1	0	0	53	593	0	108		0	0	0	0	108	2		0	0	0	0	0	2	1	1.000000	50	589	0	104	2								-13.066960	1	1	0	0		1	2	3	5	2.236140	1	0.240000	3.570000	0.427538	0.920000	0.690000	1.000000	1.000000	0.907788	0.920000	1	8.000000e-01	1
LRP1B	53353	broad.mit.edu	37	2	141128374	141128374	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr2:141128374C>T	ENST00000389484.3	-	71	11884	c.10913G>A	c.(10912-10914)cGg>cAg	p.R3638Q		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B			606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)			ATTTTTGCACCGAAACTGATC	0.388000										TSP Lung(27;0.18)			Colon(99;50 2074 2507 20106)											0							SO:0001583	missense			ENST00000389484.3	1	1	hg19	CCDS2182.1	.	.	.	.	.	.	.	.	.	.	C	12.65	2.000256	0.35320	.	.	ENSG00000168702	ENST00000389484;ENST00000544579	T	0.41400	1.0	5.12	4.23	0.50019	.	0.218941	0.31335	N	0.007839	T	0.18173	0.0436	N	0.05608	-0.01	0.24759	N	0.992934	B	0.06786	0.001	B	0.04013	0.001	T	0.26087	-1.0113	10	0.02654	T	1	.	9.1573	0.37000	0.0:0.8316:0.0:0.1684	.	3638	Q9NZR2	LRP1B_HUMAN	Q	3638;3576	ENSP00000374135:R3638Q	ENSP00000374135:R3638Q	R	-	2	0	LRP1B	140844844	0.931000	0.31567	1.000000	0.80357	0.996000	0.88848	1.822000	0.39052	1.132000	0.42129	0.491000	0.48974	CGG		TCGA-2J-AABO-01A-21D-A40W-08	LRP1B-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000254736.2	1	0	0	39	589	1	87		0	0	0	1	87	2		0	0	0	0	0	2	1	0.985140	39	582	1	83	23								-2.458456	0	1	121406	7	40	1	2	3	5	2.236140	1	0.240000	3.570000	0.427538	0.700000	0.490000	1.000000	0.700000	0.722438	0.700000	0	5.900000e-01	8.500000e-01
NBEAL1	65065	broad.mit.edu	37	2	204009335	204009335	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr2:204009335G>A	ENST00000449802.1	+	31	5107	c.4774G>A	c.(4774-4776)Gca>Aca	p.A1592T		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1			37					TTGTGCAATGGCATCAGCTAA	0.403000																								0							SO:0001583	missense			ENST00000449802.1	0	1	hg19	CCDS46495.1	.	.	.	.	.	.	.	.	.	.	G	33	5.198565	0.94997	.	.	ENSG00000144426	ENST00000449802;ENST00000340268	T	0.74106	-0.81	5.8	5.8	0.92144	.	0.798454	0.11851	N	0.523346	D	0.88074	0.6339	M	0.77313	2.365	0.80722	D	1	D;D	0.89917	1.0;1.0	D;D	0.83275	0.996;0.996	D	0.86728	0.1946	10	0.87932	D	0	.	19.6495	0.95795	0.0:0.0:1.0:0.0	.	1592;1581	Q6ZS30;C9JGK5	NBEL1_HUMAN;.	T	1592	ENSP00000399903:A1592T	ENSP00000344985:A1592T	A	+	1	0	NBEAL1	203717580	1.000000	0.71417	1.000000	0.80357	0.997000	0.91878	9.444000	0.97578	2.748000	0.94277	0.655000	0.94253	GCA		TCGA-2J-AABO-01A-21D-A40W-08	NBEAL1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000333982.4	0	0	0	5	417	0	76	0	6.904691e-04	0	3	0	76	2		0	0	0	0	0	2	1	0.935110	5	410	0	75	2								-2.542651	1	1	0	0		1	2	3	5	2.236140	1	0.240000	3.570000	0.427538	0.140000	0.040000	1.000000	0.140000	0.217387	0.140000	0	8.000000e-02	2.500000e-01
EPHA4	2043	broad.mit.edu	37	2	222307700	222307700	+	Missense_Mutation	SNP	T	T	G			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr2:222307700T>G	ENST00000281821.2	-	11	1964	c.1923A>C	c.(1921-1923)aaA>aaC	p.K641N	EPHA4_ENST00000409938.1_Missense_Mutation_p.K641N|EPHA4_ENST00000392071.4_Missense_Mutation_p.K590N|EPHA4_ENST00000409854.1_Missense_Mutation_p.K641N	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4			49		Renal(207;0.0183)			TGCCAGGCACTTTGAGACGCC	0.448000																								0							SO:0001583	missense			ENST00000281821.2	1	1	hg19	CCDS2447.1	.	.	.	.	.	.	.	.	.	.	T	19.22	3.785330	0.70337	.	.	ENSG00000116106	ENST00000281821;ENST00000409854;ENST00000409938;ENST00000392071	D;D;D;D	0.83335	-1.71;-1.71;-1.71;-1.71	6.06	4.91	0.64330	Serine-threonine/tyrosine-protein kinase (1);Protein kinase-like domain (1);Tyrosine-protein kinase, catalytic domain (1);Protein kinase, catalytic domain (1);	0.000000	0.85682	D	0.000000	D	0.84642	0.5517	L	0.47078	1.49	0.58432	D	0.999997	P	0.52463	0.953	P	0.58454	0.839	D	0.84672	0.0712	10	0.87932	D	0	.	8.1583	0.31183	0.0:0.2111:0.0:0.7889	.	641	P54764	EPHA4_HUMAN	N	641;641;641;590	ENSP00000281821:K641N;ENSP00000386276:K641N;ENSP00000386829:K641N;ENSP00000375923:K590N	ENSP00000281821:K641N	K	-	3	2	EPHA4	222015944	1.000000	0.71417	1.000000	0.80357	0.999000	0.98932	1.233000	0.32648	1.121000	0.41925	0.533000	0.62120	AAA		TCGA-2J-AABO-01A-21D-A40W-08	EPHA4-201	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000256836.3	1	0	0	35	476	0	85	0	1.535855e-01	0	10	0	85	2		0	0	0	0	0	2	1	1.000000	34	470	0	84	2								-8.807678	1	1	0	0		1	2	3	5	2.236140	1	0.240000	3.570000	0.427538	0.770000	0.540000	1.000000	1.000000	0.788240	0.770000	0	6.500000e-01	9.400000e-01
GBX2	2637	broad.mit.edu	37	2	237074778	237074778	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr2:237074778C>T	ENST00000306318.4	-	2	1223	c.826G>A	c.(826-828)Gag>Aag	p.E276K	GBX2_ENST00000551105.1_3'UTR|AC079135.1_ENST00000415226.1_RNA|AC079135.1_ENST00000483218.1_RNA|GBX2_ENST00000465889.1_5'UTR	NM_001485.2	NP_001476.2	P52951	GBX2_HUMAN	gastrulation brain homeobox 2			7		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)			TGCGAGCGCTCGGTCAAGGAG	0.602000																								0							SO:0001583	missense			ENST00000306318.4	0	1	hg19	CCDS2515.1	.	.	.	.	.	.	.	.	.	.	C	31	5.081431	0.94050	.	.	ENSG00000168505	ENST00000306318	D	0.96300	-3.97	4.66	4.66	0.58398	Homeobox, eukaryotic (1);Homeodomain-related (1);Homeobox (3);Homeodomain-like (1);	0.000000	0.85682	D	0.000000	D	0.96482	0.8852	L	0.31578	0.945	0.80722	D	1	D	0.89917	1.0	D	0.97110	1.0	D	0.96285	0.9209	10	0.36615	T	0.2	-15.9796	17.5569	0.87894	0.0:1.0:0.0:0.0	.	276	P52951	GBX2_HUMAN	K	276	ENSP00000302251:E276K	ENSP00000302251:E276K	E	-	1	0	GBX2	236739517	1.000000	0.71417	1.000000	0.80357	0.887000	0.51463	5.990000	0.70595	2.133000	0.65898	0.561000	0.74099	GAG		TCGA-2J-AABO-01A-21D-A40W-08	GBX2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000257078.3	0	0	0	10	514	1	95		0	0	0	1	95	2		0	0	0	0	0	2	1	0.996585	10	503	0	95	2								-2.659535	1	1	0	0		1	2	3	5	2.236140	1	0.240000	3.570000	0.427538	0.220000	0.100000	1.000000	0.200000	0.286707	0.220000	0	1.500000e-01	3.300000e-01
ESPNL	339768	broad.mit.edu	37	2	239037368	239037368	+	Silent	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr2:239037368G>A	ENST00000343063.3	+	8	1499	c.1236G>A	c.(1234-1236)gcG>gcA	p.A412A	ESPNL_ENST00000409169.1_Silent_p.A368A|ESPNL_ENST00000409506.1_Silent_p.A44A	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like			13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)			CGGCGCTGGCGGGGGACACCT	0.701000																								0							SO:0001819	synonymous_variant			ENST00000343063.3	0	1	hg19	CCDS2525.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	ESPNL-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000257164.2	1	0	1	9	42	0	12		0	0	0	0	12	2		0	0	0	0	0	2	1	0.995652	9	42	0	12	2								-8.850166	1	1	120072	2	19	1	2	3	5	2.236140	1	0.240000	3.570000	0.427538	0.990000	0.990000	1.000000	1.000000	0.997630	0.990000	1	9.900000e-01	1
GPR113	165082	broad.mit.edu	37	2	26534165	26534165	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr2:26534165C>T	ENST00000311519.1	-	11	2430	c.2431G>A	c.(2431-2433)Gcc>Acc	p.A811T	GPR113_ENST00000333478.6_Missense_Mutation_p.A612T|GPR113_ENST00000541401.1_Missense_Mutation_p.A414T|GPR113_ENST00000459892.1_5'UTR|GPR113_ENST00000421160.2_Missense_Mutation_p.A742T	NM_001145168.1	NP_001138640.1	Q8IZF5	GP113_HUMAN	G protein-coupled receptor 113			24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				TTGAGCAGGGCGGCGTGGCGG	0.622000																								0							SO:0001583	missense			ENST00000311519.1	0	1	hg19	CCDS46239.1	.	.	.	.	.	.	.	.	.	.	C	6.411	0.443938	0.12164	.	.	ENSG00000173567	ENST00000541401;ENST00000333478;ENST00000421160;ENST00000311519	T;T;T;T	0.43294	0.95;0.95;0.95;0.95	6.0	1.07	0.20283	GPCR, family 2-like (1);	.	.	.	.	T	0.31389	0.0795	L	0.47016	1.485	0.45515	D	0.998478	P;P;B;P	0.42409	0.779;0.72;0.378;0.497	B;B;B;B	0.43680	0.427;0.209;0.427;0.169	T	0.12142	-1.0559	9	0.22109	T	0.4	-11.1476	2.2265	0.03985	0.1221:0.4838:0.1187:0.2754	.	742;612;811;414	E9PEV1;Q8IZF5-2;Q8IZF5;F5H1E4	.;.;GP113_HUMAN;.	T	414;612;742;811	ENSP00000445729:A414T;ENSP00000327396:A612T;ENSP00000388537:A742T;ENSP00000307831:A811T	ENSP00000307831:A811T	A	-	1	0	GPR113	26387669	0.001000	0.12720	0.052000	0.19188	0.087000	0.18053	-0.211000	0.09332	-0.077000	0.12752	-0.703000	0.03666	GCC		TCGA-2J-AABO-01A-21D-A40W-08	GPR113-004	PUTATIVE	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000316892.1	1	0	0	13	118	0	22		0	0	0	0	22	2		0	0	0	0	0	2	1	0.999562	13	115	0	21	2								-7.644387	1	1	0	0		1	2	2	4	2.069894	0	0.240000	3.570000	0.384715	0.990000	0.590000	1.000000	1.000000	0.926939	0.990000	1	7.900000e-01	1
CRIM1	51232	broad.mit.edu	37	2	36726453	36726453	+	Silent	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr2:36726453C>T	ENST00000280527.2	+	8	1831	c.1464C>T	c.(1462-1464)cgC>cgT	p.R488R		NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)			45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)			GTTTCAAACGCGATCACAATG	0.408000																								0							SO:0001819	synonymous_variant			ENST00000280527.2	1	1	hg19	CCDS1783.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	CRIM1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000216878.2	1	0	1	56	457	0	77	0	6.328457e-01	1	18	0	77	2		0	0	0	0	0	2	1	1.000000	55	453	0	75	2								-19.041460	1	1	121412	6	44	1	2	2	4	2.072110	0	0.240000	3.570000	0.385908	0.990000	0.860000	1.000000	1.000000	0.988577	0.990000	1	9.900000e-01	1
QPCT	25797	broad.mit.edu	37	2	37571893	37571893	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr2:37571893C>T	ENST00000338415.3	+	1	177	c.19C>T	c.(19-21)Cgg>Tgg	p.R7W	QPCT_ENST00000537448.1_Missense_Mutation_p.R7W	NM_012413.3	NP_036545.1	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase			17		Ovarian(717;0.051)|all_hematologic(82;0.21)			CGGAAGACACCGGCGCGTCGT	0.711000																								0							SO:0001583	missense			ENST00000338415.3	0	1	hg19	CCDS1790.1	.	.	.	.	.	.	.	.	.	.	C	10.80	1.451494	0.26074	.	.	ENSG00000115828	ENST00000338415;ENST00000404976;ENST00000537448	T;T;T	0.31510	1.49;1.49;1.49	4.57	1.6	0.23607	.	1.023380	0.07800	N	0.956267	T	0.27594	0.0678	L	0.53249	1.67	0.09310	N	1	B;B	0.13145	0.007;0.004	B;B	0.04013	0.001;0.001	T	0.34104	-0.9842	10	0.66056	D	0.02	.	4.3052	0.10944	0.1911:0.5985:0.0:0.2104	.	7;7	Q16769-2;Q16769	.;QPCT_HUMAN	W	7	ENSP00000344829:R7W;ENSP00000385391:R7W;ENSP00000441606:R7W	ENSP00000344829:R7W	R	+	1	2	QPCT	37425397	0.000000	0.05858	0.028000	0.17463	0.209000	0.24338	-0.551000	0.06027	0.439000	0.26476	0.455000	0.32223	CGG		TCGA-2J-AABO-01A-21D-A40W-08	QPCT-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000218572.2	0	0	0	6	60	0	14	0	3.849844e-01	0	13	0	14	2		0	0	0	0	0	2	1	0.953953	6	53	0	11	2								-11.385630	1	1	0	0		1	2	2	4	2.072110	0	0.240000	3.570000	0.385908	0.990000	0.420000	1.000000	1.000000	0.872975	0.990000	1	6.600000e-01	1
ABCG8	64241	broad.mit.edu	37	2	44102330	44102330	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr2:44102330G>A	ENST00000272286.2	+	11	1624	c.1534G>A	c.(1534-1536)Ggg>Agg	p.G512R		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	p.G512W(1)		45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)		Ezetimibe(DB00973)	CATCATCTACGGGATGCCCAC	0.562000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000272286.2	1	1	hg19	CCDS1815.1	.	.	.	.	.	.	.	.	.	.	G	15.44	2.834015	0.50951	0.0	1.16E-4	ENSG00000143921	ENST00000272286	T	0.72394	-0.65	4.62	3.72	0.42706	ABC-2 type transporter (1);	0.264244	0.42821	N	0.000659	T	0.65165	0.2665	M	0.63428	1.95	0.44388	D	0.997299	P;P	0.39665	0.631;0.682	B;B	0.35859	0.135;0.212	T	0.62501	-0.6841	10	0.23891	T	0.37	.	14.5487	0.68050	0.0:0.1475:0.8525:0.0	.	511;512	Q9H221-2;Q9H221	.;ABCG8_HUMAN	R	512	ENSP00000272286:G512R	ENSP00000272286:G512R	G	+	1	0	ABCG8	43955834	1.000000	0.71417	0.729000	0.30791	0.885000	0.51271	6.127000	0.71642	0.913000	0.36797	0.467000	0.42956	GGG		TCGA-2J-AABO-01A-21D-A40W-08	ABCG8-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000250671.1	1	0	1	69	329	0	86	1	2.132015e-01	2	3	0	86	2		0	0	0	0	0	2	1	1.000000	67	324	0	85	2								-2.224851	0	1	121412	2	35	1	2	2	4	2.072110	0	0.240000	3.570000	0.385908	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
MAL	4118	broad.mit.edu	37	2	95715409	95715409	+	Silent	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr2:95715409C>T	ENST00000309988.4	+	3	454	c.345C>T	c.(343-345)gaC>gaT	p.D115D	AC103563.9_ENST00000442200.1_RNA|MAL_ENST00000349807.3_Intron|MAL_ENST00000353004.3_Intron|MAL_ENST00000354078.3_Silent_p.D59D	NM_002371.3	NP_002362.1	P21145	MAL_HUMAN	mal, T-cell differentiation protein			10					CGATGCAAGACGGCTTCACCT	0.647000																								0							SO:0001819	synonymous_variant			ENST00000309988.4	1	1	hg19	CCDS2006.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	MAL-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000254982.3	1	0	0	97	410	0	74	0	9.714192e-02	0	3	0	74	2		0	0	0	0	0	2	1	1.000000	96	405	0	73	2								-20.000000	1	1	121412	5	39	1	2	2	4	2.072110	0	0.240000	3.570000	0.385908	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
CBLB	868	broad.mit.edu	37	3	105456084	105456084	+	Silent	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr3:105456084C>T	ENST00000264122.4	-	8	1323	c.1002G>A	c.(1000-1002)ggG>ggA	p.G334G	CBLB_ENST00000394027.3_Silent_p.G356G|CBLB_ENST00000405772.1_Silent_p.G334G|CBLB_ENST00000403724.1_Silent_p.G334G|CBLB_ENST00000545639.1_3'UTR	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase			49					TATAACTCCTCCCATCAGGAT	0.264000			Mis S		AML								GBM(93;588 1337 9788 29341 43499)		Rec	yes		3	3q13.11	868	Cas-Br-M (murine) ecotropic retroviral transforming sequence b		L	0							SO:0001819	synonymous_variant			ENST00000264122.4	1	1	hg19	CCDS2948.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	CBLB-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000319417.2	1	0	0	39	776	0	91	0	4.338805e-02	1	6	0	91	2		0	0	0	0	0	2	1	1.000000	39	768	0	88	2								-3.016297	1	1	0	0		1	4	6	10	3.317498	1	0.240000	3.570000	0.612245	0.780000	0.550000	1.000000	1.000000	0.794561	0.780000	0	6.600000e-01	9.200000e-01
KNG1	3827	broad.mit.edu	37	3	186443035	186443035	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr3:186443035C>T	ENST00000265023.4	+	4	762	c.550C>T	c.(550-552)Cgg>Tgg	p.R184W	KNG1_ENST00000447445.1_Missense_Mutation_p.R184W|RP11-573D15.8_ENST00000599314.1_RNA|KNG1_ENST00000287611.2_Missense_Mutation_p.R184W	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1			21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)		TGAAGTAAAACGGGCCCAAAG	0.398000																								0							SO:0001583	missense			ENST00000265023.4	1	1	hg19	CCDS43183.1	.	.	.	.	.	.	.	.	.	.	C	21.6	4.170951	0.78452	.	.	ENSG00000113889	ENST00000287611;ENST00000265023;ENST00000447445;ENST00000432028	T;T;T	0.30182	2.38;2.38;1.54	4.92	-1.75	0.08031	Proteinase inhibitor I25, cystatin (2);	1.061570	0.07280	N	0.870615	T	0.43033	0.1229	M	0.61703	1.905	0.09310	N	1	D;D	0.71674	0.998;0.998	D;D	0.66979	0.948;0.928	T	0.34477	-0.9827	10	0.72032	D	0.01	2.3875	1.214	0.01910	0.3907:0.174:0.2979:0.1373	.	184;184	P01042;P01042-2	KNG1_HUMAN;.	W	184;184;184;172	ENSP00000287611:R184W;ENSP00000265023:R184W;ENSP00000396025:R184W	ENSP00000265023:R184W	R	+	1	2	KNG1	187925729	0.000000	0.05858	0.000000	0.03702	0.980000	0.70556	-0.332000	0.07904	-0.388000	0.07797	0.561000	0.74099	CGG		TCGA-2J-AABO-01A-21D-A40W-08	KNG1-002	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000317738.1	1	0	1	80	358	0	101		0	0	0	0	101	2		0	0	0	0	0	2	1	1.000000	80	352	0	96	2								-20.000000	1	1	121412	58	47	1	1	3	4	2.098732	1	0.240000	3.570000	0.387097	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
TDGF1	6997	broad.mit.edu	37	3	46621337	46621337	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr3:46621337G>A	ENST00000296145.5	+	4	1065	c.332G>A	c.(331-333)cGc>cAc	p.R111H	TDGF1_ENST00000542931.1_Missense_Mutation_p.R95H|LRRC2_ENST00000296144.3_Intron	NM_003212.3	NP_003203.1	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1			8					CACGATGTGCGCAAAGAGTAA	0.547000																								0							SO:0001583	missense			ENST00000296145.5	0	1	hg19	CCDS2742.1	.	.	.	.	.	.	.	.	.	.	G	12.93	2.084278	0.36758	.	.	ENSG00000241186	ENST00000542931;ENST00000296145	T;T	0.66280	-0.19;-0.2	4.44	2.64	0.31445	.	0.126759	0.53938	N	0.000042	T	0.57344	0.2047	M	0.74881	2.28	0.30445	N	0.77578	B	0.11235	0.004	B	0.04013	0.001	T	0.57051	-0.7877	10	0.46703	T	0.11	.	7.3485	0.26676	0.1779:0.0:0.8221:0.0	.	111	P13385	TDGF1_HUMAN	H	95;111	ENSP00000446375:R95H;ENSP00000296145:R111H	ENSP00000296145:R111H	R	+	2	0	AC104304.1	46596341	0.891000	0.30450	0.005000	0.12908	0.061000	0.15899	2.995000	0.49441	0.625000	0.30304	0.655000	0.94253	CGC		TCGA-2J-AABO-01A-21D-A40W-08	TDGF1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000257378.2	0	0	0	7	370	0	79	0	0	0	1	0	79	2		0	0	0	0	0	2	1	0.979509	7	363	0	78	2								-2.396585	0	1	121412	6	42	1	0	0	0	1.662334	0	0.240000	3.570000	0.227014	0.150000	0.060000	0.300000	0.150000	0.171389	0.150000	0	1.000000e-01	2.300000e-01
FAM107A	11170	broad.mit.edu	37	3	58555463	58555463	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr3:58555463C>T	ENST00000394481.1	-	3	683	c.125G>A	c.(124-126)cGg>cAg	p.R42Q	FAM107A_ENST00000474531.1_Missense_Mutation_p.R73Q|FAM107A_ENST00000447756.2_Missense_Mutation_p.R70Q|FAM107A_ENST00000464064.1_Missense_Mutation_p.R42Q|FAM107A_ENST00000360997.2_Missense_Mutation_p.R42Q	NM_001282713.1|NM_007177.2	NP_001269642.1|NP_009108.1	O95990	F107A_HUMAN	family with sequence similarity 107, member A			13					CTGGTGACTCCGAGAGGCCTT	0.632000																								0							SO:0001583	missense			ENST00000394481.1	1	1	hg19	CCDS2892.1	.	.	.	.	.	.	.	.	.	.	C	20.9	4.065072	0.76187	.	.	ENSG00000168309	ENST00000360997;ENST00000394481;ENST00000464064;ENST00000474531;ENST00000447756;ENST00000465970	T;T;T;T;T;T	0.45668	0.89;0.89;0.89;0.89;0.89;0.89	4.48	3.59	0.41128	.	0.241877	0.39274	N	0.001412	T	0.44582	0.1300	M	0.73598	2.24	0.31818	N	0.626326	P;D;P;P	0.55800	0.727;0.973;0.898;0.898	B;P;B;B	0.47346	0.259;0.544;0.284;0.284	T	0.55515	-0.8129	10	0.36615	T	0.2	-30.2881	7.6386	0.28280	0.0:0.7936:0.0:0.2064	.	70;42;73;42	B7ZAY5;O95990-2;B3KNQ4;O95990	.;.;.;F107A_HUMAN	Q	42;42;42;73;70;42	ENSP00000354270:R42Q;ENSP00000377991:R42Q;ENSP00000419529:R42Q;ENSP00000419124:R73Q;ENSP00000400858:R70Q;ENSP00000418038:R42Q	ENSP00000354270:R42Q	R	-	2	0	FAM107A	58530503	0.001000	0.12720	0.984000	0.44739	0.807000	0.45602	0.874000	0.28065	2.217000	0.71921	0.655000	0.94253	CGG		TCGA-2J-AABO-01A-21D-A40W-08	FAM107A-004	KNOWN	alternative_5_UTR|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000353585.1	1	0	0	28	298	0	74	0	2.205496e-01	0	10	0	74	2		0	0	0	0	0	2	1	1.000000	28	292	0	72	2								-2.774726	1	1	121412	1	33	1	0	0	0	1.662334	0	0.240000	3.570000	0.227014	0.700000	0.480000	0.960000	0.690000	0.715744	0.700000	0	5.800000e-01	8.400000e-01
EGF	1950	broad.mit.edu	37	4	110880564	110880564	+	Missense_Mutation	SNP	C	C	G			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr4:110880564C>G	ENST00000265171.5	+	6	1482	c.1037C>G	c.(1036-1038)gCc>gGc	p.A346G	EGF_ENST00000503392.1_Missense_Mutation_p.A346G|EGF_ENST00000509793.1_Intron	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor			50		Hepatocellular(203;0.0893)		Sucralfate(DB00364)	GAGGGATACGCCCTAAGTCGA	0.498000																								0							SO:0001583	missense			ENST00000265171.5	1	1	hg19	CCDS3689.1	.	.	.	.	.	.	.	.	.	.	C	12.16	1.853597	0.32791	.	.	ENSG00000138798	ENST00000265171;ENST00000503392	D;D	0.87491	-2.26;-2.26	5.18	4.33	0.51752	Epidermal growth factor-like (1);EGF-like region, conserved site (1);	0.628717	0.18234	N	0.147478	T	0.69797	0.3151	N	0.14661	0.345	0.09310	N	1	P;P	0.41041	0.554;0.736	B;B	0.33196	0.159;0.159	T	0.60347	-0.7281	10	0.15952	T	0.53	.	7.5645	0.27870	0.0:0.7657:0.0:0.2343	.	346;346	E7EVD2;P01133	.;EGF_HUMAN	G	346	ENSP00000265171:A346G;ENSP00000421384:A346G	ENSP00000265171:A346G	A	+	2	0	EGF	111100013	0.000000	0.05858	0.004000	0.12327	0.002000	0.02628	0.849000	0.27723	2.426000	0.82243	0.655000	0.94253	GCC		TCGA-2J-AABO-01A-21D-A40W-08	EGF-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000255065.1	1	0	1	67	272	0	63	0	4.023255e-02	1	1	0	63	2		0	0	0	0	0	2	1	1.000000	67	268	0	61	2								-20.000000	1	1	121410	1	31	1	1	3	4	1.949936	0	0.240000	3.570000	0.338440	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
ANK2	287	broad.mit.edu	37	4	114275125	114275125	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr4:114275125G>A	ENST00000357077.4	+	38	5404	c.5351G>A	c.(5350-5352)cGa>cAa	p.R1784Q	ANK2_ENST00000264366.6_Missense_Mutation_p.R1751Q|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal			248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)			CAGAAAGGTCGAAGCAAGTTG	0.498000																								0							SO:0001583	missense			ENST00000357077.4	1	1	hg19	CCDS3702.1	.	.	.	.	.	.	.	.	.	.	G	21.3	4.124084	0.77436	.	.	ENSG00000145362	ENST00000357077;ENST00000264366	T;T	0.69435	-0.4;-0.36	5.7	5.7	0.88788	.	0.000000	0.50627	D	0.000101	T	0.76076	0.3937	L	0.54323	1.7	0.80722	D	1	D;D	0.71674	0.994;0.998	P;P	0.59595	0.716;0.86	T	0.74054	-0.3788	9	.	.	.	.	18.0216	0.89257	0.0:0.0:1.0:0.0	.	1751;1784	Q01484;Q01484-4	ANK2_HUMAN;.	Q	1784;1751	ENSP00000349588:R1784Q;ENSP00000264366:R1751Q	.	R	+	2	0	ANK2	114494574	1.000000	0.71417	0.998000	0.56505	0.994000	0.84299	3.512000	0.53407	2.683000	0.91414	0.655000	0.94253	CGA		TCGA-2J-AABO-01A-21D-A40W-08	ANK2-001	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000256422.2	1	0	1	93	707	0	100		0	0	0	0	100	2		0	0	0	0	0	2	1	1.000000	92	700	0	99	2								-20.000000	1	1	121406	2	40	1	1	3	4	1.949936	0	0.240000	3.570000	0.338440	0.990000	0.920000	1.000000	1.000000	0.994710	0.990000	1	9.900000e-01	1
IL21	59067	broad.mit.edu	37	4	123542066	123542066	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr4:123542066C>T	ENST00000264497.3	-	1	158	c.101G>A	c.(100-102)cGc>cAc	p.R34H	IL21-AS1_ENST00000417927.1_RNA	NM_001207006.2|NM_021803.3	NP_001193935.1|NP_068575.1	Q9HBE4	IL21_HUMAN	interleukin 21			8					AATCATGTGGCGATCTTGACC	0.398000																								0							SO:0001583	missense			ENST00000264497.3	1	1	hg19	CCDS3727.1	.	.	.	.	.	.	.	.	.	.	C	12.73	2.025754	0.35701	.	.	ENSG00000138684	ENST00000264497	.	.	.	5.1	3.33	0.38152	.	0.278577	0.26092	N	0.026394	T	0.42988	0.1227	L	0.47716	1.5	0.32156	N	0.583601	B;B	0.14438	0.008;0.01	B;B	0.16289	0.009;0.015	T	0.48854	-0.8998	9	0.51188	T	0.08	-2.2109	8.1174	0.30950	0.1657:0.7506:0.0:0.0838	.	27;27	Q9HBE4-2;Q9HBE4	.;IL21_HUMAN	H	34	.	ENSP00000264497:R34H	R	-	2	0	IL21	123761516	0.000000	0.05858	0.925000	0.36789	0.899000	0.52679	0.295000	0.19065	0.683000	0.31428	0.655000	0.94253	CGC		TCGA-2J-AABO-01A-21D-A40W-08	IL21-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000256713.1	1	0	1	40	380	0	85		0	0	0	0	85	2		0	0	0	0	0	2	1	1.000000	40	378	0	83	2								-3.318794	1	1	121412	1	30	1	1	3	4	1.949936	0	0.240000	3.570000	0.338440	0.960000	0.680000	1.000000	1.000000	0.922103	0.960000	1	8.000000e-01	1
TBC1D9	23158	broad.mit.edu	37	4	141543566	141543566	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr4:141543566C>A	ENST00000442267.2	-	21	3658	c.3584G>T	c.(3583-3585)gGc>gTc	p.G1195V		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)			31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)			TGCCGCCGTGCCCTGGCCGCT	0.662000																								0							SO:0001583	missense			ENST00000442267.2	0	1	hg19	CCDS47136.1	.	.	.	.	.	.	.	.	.	.	C	13.02	2.113280	0.37339	.	.	ENSG00000109436	ENST00000442267	T	0.26957	1.7	5.01	5.01	0.66863	.	0.419120	0.26951	N	0.021662	T	0.21509	0.0518	L	0.53249	1.67	0.58432	D	0.999999	B	0.30763	0.294	B	0.24974	0.057	T	0.03739	-1.1008	10	0.23302	T	0.38	.	9.4508	0.38725	0.0:0.9038:0.0:0.0962	.	1195	Q6ZT07	TBCD9_HUMAN	V	1195	ENSP00000411197:G1195V	ENSP00000411197:G1195V	G	-	2	0	TBC1D9	141763016	0.014000	0.17966	0.914000	0.36105	0.931000	0.56810	0.503000	0.22610	2.319000	0.78375	0.655000	0.94253	GGC		TCGA-2J-AABO-01A-21D-A40W-08	TBC1D9-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000364806.1	1	0	1	9	89	0	21	1	4.080231e-01	8	6	0	21	2		0	0	0	0	0	2	1	0.994435	9	87	0	20	2								-14.948450	1	1	0	0		1	1	2	3	1.746792	0	0.240000	3.570000	0.256942	0.850000	0.410000	1.000000	1.000000	0.819014	0.850000	1	6.000000e-01	1
ADAM29	11086	broad.mit.edu	37	4	175897289	175897289	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr4:175897289G>A	ENST00000359240.3	+	5	1283	c.613G>A	c.(613-615)Gtc>Atc	p.V205I	ADAM29_ENST00000404450.4_Missense_Mutation_p.V205I|ADAM29_ENST00000514159.1_Missense_Mutation_p.V205I|ADAM29_ENST00000445694.1_Missense_Mutation_p.V205I|RP13-577H12.2_ENST00000507525.1_RNA	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	p.V205I(2)		93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)			AATTGTAGTCGTCATTGATAA	0.348000													Ovarian(140;1727 1835 21805 25838 41440)											2	Substitution - Missense(2)						SO:0001583	missense			ENST00000359240.3	0	1	hg19	CCDS3823.1	.	.	.	.	.	.	.	.	.	.	G	14.34	2.504909	0.44558	.	.	ENSG00000168594	ENST00000359240;ENST00000445694;ENST00000404450;ENST00000514159	T;T;T;T	0.70631	-0.5;-0.5;-0.5;-0.5	3.74	2.9	0.33743	Metallopeptidase, catalytic domain (1);Peptidase M12B, ADAM/reprolysin (2);	0.330976	0.16461	N	0.213409	T	0.75627	0.3875	M	0.64080	1.96	0.09310	N	1	D	0.59357	0.985	P	0.58970	0.849	T	0.63435	-0.6638	9	.	.	.	.	7.3233	0.26540	0.1206:0.0:0.8794:0.0	.	205	Q9UKF5	ADA29_HUMAN	I	205	ENSP00000352177:V205I;ENSP00000414544:V205I;ENSP00000384229:V205I;ENSP00000423517:V205I	.	V	+	1	0	ADAM29	176133864	0.714000	0.27936	0.004000	0.12327	0.001000	0.01503	1.522000	0.35921	1.155000	0.42497	0.643000	0.83706	GTC		TCGA-2J-AABO-01A-21D-A40W-08	ADAM29-201	KNOWN	basic|appris_principal|exp_conf|CCDS	protein_coding	protein_coding		0	0	0	7	291	0	71		0	0	0	0	71	2		0	0	0	0	0	2	1	0.980708	7	290	0	69	2								-3.194611	1	1	121412	3	37	1	1	2	3	1.746792	0	0.240000	3.570000	0.256942	0.220000	0.090000	1.000000	0.200000	0.337793	0.220000	0	1.400000e-01	4.200000e-01
FAM193A	8603	broad.mit.edu	37	4	2702034	2702034	+	Missense_Mutation	SNP	G	G	A	rs139214563	byFrequency	TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr4:2702034G>A	ENST00000324666.5	+	17	3613	c.3262G>A	c.(3262-3264)Gac>Aac	p.D1088N	FAM193A_ENST00000545951.1_Missense_Mutation_p.D1088N|FAM193A_ENST00000382839.3_Missense_Mutation_p.D1088N|FAM193A_ENST00000505311.1_Missense_Mutation_p.D1088N|FAM193A_ENST00000502458.1_Missense_Mutation_p.D1110N	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A			40					TAAGGTGGTCGACCTCATGTC	0.542000																								0							SO:0001583	missense			ENST00000324666.5	1	1	hg19	CCDS58875.1	2	9.157509157509158E-4	2	0.0040650406504065045	0	0.0	0	0.0	0	0.0	G	9.038	0.988898	0.18966	0.006128	0.0	ENSG00000125386	ENST00000382839;ENST00000324666;ENST00000545951;ENST00000502458;ENST00000513350	T;T;T;T;T	0.41758	0.99;0.99;0.99;0.99;1.43	5.7	4.86	0.63082	.	0.487155	0.22559	N	0.058494	T	0.22360	0.0539	L	0.36672	1.1	0.09310	N	1	B;B;P;B;B	0.49253	0.012;0.012;0.921;0.012;0.012	B;B;B;B;B	0.35971	0.005;0.005;0.215;0.005;0.005	T	0.08411	-1.0723	10	0.28530	T	0.3	-8.008	13.732	0.62794	0.0736:0.0:0.9264:0.0	.	1088;1110;1088;1110;1088	B9EGR0;E9PFA1;P78312;B7ZM85;P78312-2	.;.;F193A_HUMAN;.;.	N	1088;1088;1088;1110;942	ENSP00000372290:D1088N;ENSP00000324587:D1088N;ENSP00000443617:D1088N;ENSP00000427505:D1110N;ENSP00000427260:D942N	ENSP00000324587:D1088N	D	+	1	0	FAM193A	2671832	1.000000	0.71417	0.024000	0.17045	0.022000	0.10575	5.299000	0.65716	1.425000	0.47237	0.655000	0.94253	GAC		TCGA-2J-AABO-01A-21D-A40W-08	FAM193A-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000360903.1	1	0	0	12	110	0	35	1	5.886069e-01	3	16	0	35	2		0	0	0	0	0	2	1	0.999199	12	108	0	34	2								-6.053187	1	1	121412	75	48	1	1	2	3	1.900906	0	0.240000	3.570000	0.321429	0.930000	0.520000	1.000000	1.000000	0.878628	0.930000	1	7.000000e-01	1
POLR2B	5431	broad.mit.edu	37	4	57871882	57871882	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr4:57871882G>A	ENST00000381227.1	+	10	1627	c.1214G>A	c.(1213-1215)aGa>aAa	p.R405K	RNU6-998P_ENST00000515894.1_RNA|POLR2B_ENST00000431623.2_Missense_Mutation_p.R330K|POLR2B_ENST00000441246.2_Missense_Mutation_p.R398K|POLR2B_ENST00000314595.5_Missense_Mutation_p.R405K			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa			52	Glioma(25;0.08)|all_neural(26;0.181)				TTCTTATTTAGAGGGTAAGGA	0.413000																								0							SO:0001583	missense			ENST00000381227.1	1	1	hg19	CCDS3511.1	.	.	.	.	.	.	.	.	.	.	G	35	5.444758	0.96187	.	.	ENSG00000047315	ENST00000381227;ENST00000431623;ENST00000441246;ENST00000314595	T;T;T;T	0.77620	-1.11;-1.11;-1.11;-1.11	5.46	5.46	0.80206	RNA polymerase, beta subunit, protrusion (1);	0.000000	0.85682	D	0.000000	D	0.89083	0.6614	M	0.80982	2.52	0.80722	D	1	D;D	0.76494	0.999;0.999	D;D	0.87578	0.998;0.998	D	0.89062	0.3463	10	0.54805	T	0.06	.	19.6697	0.95907	0.0:0.0:1.0:0.0	.	330;405	C9J4M6;P30876	.;RPB2_HUMAN	K	405;330;398;405	ENSP00000370625:R405K;ENSP00000391096:R330K;ENSP00000391452:R398K;ENSP00000312735:R405K	ENSP00000312735:R405K	R	+	2	0	POLR2B	57566639	1.000000	0.71417	1.000000	0.80357	0.956000	0.61745	7.779000	0.85648	2.724000	0.93272	0.650000	0.86243	AGA		TCGA-2J-AABO-01A-21D-A40W-08	POLR2B-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000250692.1	1	0	1	42	277	0	58	0	7.077944e-01	1	17	0	58	2		0	0	0	0	0	2	1	1.000000	42	275	0	58	2								-2.842039	1	1	0	0		1	1	2	3	1.900906	0	0.240000	3.570000	0.321429	0.990000	0.910000	1.000000	1.000000	0.994670	0.990000	1	9.900000e-01	1
LIN54	132660	broad.mit.edu	37	4	83905426	83905426	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr4:83905426C>A	ENST00000340417.3	-	2	949	c.572G>T	c.(571-573)aGg>aTg	p.R191M	LIN54_ENST00000395283.2_Missense_Mutation_p.R191M|LIN54_ENST00000442461.2_Intron|LIN54_ENST00000505397.1_Missense_Mutation_p.R191M|LIN54_ENST00000446851.2_Intron|LIN54_ENST00000395282.2_Missense_Mutation_p.R191M|LIN54_ENST00000506560.1_Missense_Mutation_p.R191M|LIN54_ENST00000510557.1_Intron	NM_194282.2	NP_919258.2	Q6MZP7	LIN54_HUMAN	lin-54 DREAM MuvB core complex component			14		Hepatocellular(203;0.114)			CACCTCTGGCCTCCCTCCAAT	0.478000																								0							SO:0001583	missense			ENST00000340417.3	1	1	hg19	CCDS3599.1	.	.	.	.	.	.	.	.	.	.	C	18.90	3.720858	0.68959	.	.	ENSG00000189308	ENST00000340417;ENST00000395283;ENST00000395282;ENST00000506560;ENST00000505397	.	.	.	5.62	4.78	0.61160	.	0.149254	0.56097	D	0.000025	T	0.50034	0.1592	L	0.27053	0.805	0.58432	D	0.999993	D;P	0.54207	0.965;0.94	P;B	0.50192	0.634;0.431	T	0.55891	-0.8069	9	0.72032	D	0.01	-14.2655	14.7713	0.69681	0.0:0.9303:0.0:0.0697	.	191;191	Q6MZP7-2;Q6MZP7	.;LIN54_HUMAN	M	191	.	ENSP00000341947:R191M	R	-	2	0	LIN54	84124450	1.000000	0.71417	1.000000	0.80357	0.992000	0.81027	6.707000	0.74654	1.507000	0.48752	0.655000	0.94253	AGG		TCGA-2J-AABO-01A-21D-A40W-08	LIN54-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000252626.2	1	0	1	55	395	0	118	0	0	0	1	0	118	2		0	0	0	0	0	2	1	1.000000	55	385	0	113	2								-20.000000	1	1	0	0		1	1	3	4	1.949936	0	0.240000	3.570000	0.338440	0.990000	0.910000	1.000000	1.000000	0.994834	0.990000	1	9.900000e-01	1
DCP2	167227	broad.mit.edu	37	5	112337346	112337346	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr5:112337346G>A	ENST00000389063.2	+	7	979	c.781G>A	c.(781-783)Gct>Act	p.A261T	DCP2_ENST00000543319.1_Missense_Mutation_p.A50T|DCP2_ENST00000515408.1_Missense_Mutation_p.A261T	NM_152624.5	NP_689837	Q8IU60	DCP2_HUMAN	decapping mRNA 2			10		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)			TAGCACGCCGGCTAAACCCAC	0.373000																								0							SO:0001583	missense			ENST00000389063.2	0	1	hg19	CCDS34210.1	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	G|G	15.59|15.59	2.879558|2.879558	0.51801|0.51801	.|.	.|.	ENSG00000172795|ENSG00000172795	ENST00000515408;ENST00000389063;ENST00000543319|ENST00000513585	T;T|.	0.44881|.	0.92;0.91|.	5.79|5.79	5.79|5.79	0.91817|0.91817	.|.	0.344652|.	0.32736|.	N|.	0.005702|.	T|T	0.42245|0.42245	0.1194|0.1194	N|N	0.19112|0.19112	0.55|0.55	0.36717|0.36717	D|D	0.88097|0.88097	B;B|.	0.23442|.	0.082;0.085|.	B;B|.	0.25140|.	0.058;0.026|.	T|T	0.45948|0.45948	-0.9226|-0.9226	10|5	0.22109|.	T|.	0.4|.	-9.3311|-9.3311	9.7626|9.7626	0.40541|0.40541	0.0:0.1224:0.6305:0.2471|0.0:0.1224:0.6305:0.2471	.|.	261;261|.	Q8IU60-2;Q8IU60|.	.;DCP2_HUMAN|.	T|D	261;261;50|242	ENSP00000425770:A261T;ENSP00000373715:A261T|.	ENSP00000373715:A261T|.	A|G	+|+	1|2	0|0	DCP2|DCP2	112365245|112365245	1.000000|1.000000	0.71417|0.71417	1.000000|1.000000	0.80357|0.80357	0.990000|0.990000	0.78478|0.78478	1.265000|1.265000	0.33027|0.33027	2.727000|2.727000	0.93392|0.93392	0.643000|0.643000	0.83706|0.83706	GCT|GGC		TCGA-2J-AABO-01A-21D-A40W-08	DCP2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000370765.3	0	0	0	7	778	1	154	0	6.831672e-04	0	4	1	154	2		0	0	0	0	0	2	0	0.018220	6	763	1	150	18								-1.990900	0	1	0	0		1	1	2	3	1.864899	1	0.240000	3.570000	0.321429	0.080000	0.030000	0.170000	0.090000	0.094675	0.080000	0	5.000000e-02	1.300000e-01
FTMT	94033	broad.mit.edu	37	5	121188321	121188321	+	Silent	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr5:121188321G>A	ENST00000321339.1	+	1	672	c.663G>A	c.(661-663)ccG>ccA	p.P221P		NM_177478.1	NP_803431.1	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial			33		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)		TGGGGGCCCCGGATGCTGGCC	0.502000																								0							SO:0001819	synonymous_variant			ENST00000321339.1	0	1	hg19	CCDS4128.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	FTMT-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000250884.1	0	0	0	8	657	0	101		0	0	0	0	101	2		0	0	0	0	0	2	1	0.988607	7	646	0	97	2								-2.002557	0	1	0	0		1	1	2	3	1.864899	1	0.240000	3.570000	0.321429	0.110000	0.040000	0.210000	0.120000	0.125531	0.110000	0	7.000000e-02	1.700000e-01
CSNK1G3	1456	broad.mit.edu	37	5	122923840	122923840	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr5:122923840G>A	ENST00000361991.2	+	6	782	c.752G>A	c.(751-753)gGc>gAc	p.G251D	CSNK1G3_ENST00000521364.1_Missense_Mutation_p.G251D|CSNK1G3_ENST00000345990.4_Missense_Mutation_p.G251D|CSNK1G3_ENST00000510842.2_Missense_Mutation_p.G251D|CSNK1G3_ENST00000512718.3_Missense_Mutation_p.G176D|CSNK1G3_ENST00000511130.2_Missense_Mutation_p.G138D|CSNK1G3_ENST00000395411.1_Missense_Mutation_p.G251D|CSNK1G3_ENST00000395412.1_Missense_Mutation_p.G251D|CSNK1G3_ENST00000360683.2_Missense_Mutation_p.G251D			Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3			15		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)		CCTTGGCAAGGCTTAAAGGTA	0.284000													Pancreas(187;2868 2964 4353 6297)											0							SO:0001583	missense			ENST00000361991.2	1	1	hg19	CCDS4135.1	.	.	.	.	.	.	.	.	.	.	G	23.0	4.363004	0.82353	.	.	ENSG00000151292	ENST00000395412;ENST00000395411;ENST00000345990;ENST00000511130;ENST00000512718;ENST00000521364;ENST00000510842;ENST00000361991;ENST00000360683	T;T;T;T;T;T;T;T;T	0.10573	2.86;2.86;2.86;2.86;2.86;2.86;2.86;2.86;2.86	5.15	4.27	0.50696	Serine/threonine-protein kinase-like domain (1);Protein kinase-like domain (1);Protein kinase, catalytic domain (1);	0.000000	0.64402	D	0.000002	T	0.37433	0.1003	M	0.86097	2.795	0.80722	D	1	D;D;D;D;D;D	0.71674	0.994;0.994;0.994;0.992;0.998;0.997	D;D;D;D;D;D	0.80764	0.976;0.99;0.976;0.945;0.994;0.976	T	0.45644	-0.9247	10	0.87932	D	0	.	15.5399	0.76035	0.0:0.0:0.8604:0.1396	.	176;251;138;251;251;251	B4DSH2;A8K040;E7EVD0;Q9Y6M4-3;Q9Y6M4;Q9Y6M4-2	.;.;.;.;KC1G3_HUMAN;.	D	251;251;251;138;176;251;251;251;251	ENSP00000378807:G251D;ENSP00000378806:G251D;ENSP00000334735:G251D;ENSP00000421385:G138D;ENSP00000421998:G176D;ENSP00000429412:G251D;ENSP00000423838:G251D;ENSP00000354942:G251D;ENSP00000353904:G251D	ENSP00000334735:G251D	G	+	2	0	CSNK1G3	122951739	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	7.626000	0.83164	1.468000	0.48064	0.650000	0.86243	GGC		TCGA-2J-AABO-01A-21D-A40W-08	CSNK1G3-001	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000250900.1	1	0	1	42	375	0	50	1	4.948669e-01	2	14	0	50	2		0	0	0	0	0	2	1	1.000000	42	369	0	49	2								-14.196790	1	1	0	0		1	1	2	3	1.864899	1	0.240000	3.570000	0.321429	0.940000	0.690000	1.000000	1.000000	0.917617	0.940000	1	8.100000e-01	1
FSTL4	23105	broad.mit.edu	37	5	132559896	132559896	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr5:132559896A>G	ENST00000265342.7	-	11	1574	c.1325T>C	c.(1324-1326)cTg>cCg	p.L442P	CTB-49A3.2_ENST00000502776.1_RNA|FSTL4_ENST00000507112.1_Intron|CTB-49A3.2_ENST00000509051.1_RNA	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4			23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		CTCTCGCCACAGGATGTTTGC	0.483000																								0							SO:0001583	missense			ENST00000265342.7	1	1	hg19	CCDS34238.1	.	.	.	.	.	.	.	.	.	.	A	25.3	4.623789	0.87460	.	.	ENSG00000053108	ENST00000265342;ENST00000360575	T	0.62498	0.02	5.77	5.77	0.91146	.	0.000000	0.85682	D	0.000000	T	0.76018	0.3929	L	0.60455	1.87	0.80722	D	1	D	0.89917	1.0	D	0.87578	0.998	T	0.76313	-0.3005	10	0.49607	T	0.09	-21.8211	15.5635	0.76269	1.0:0.0:0.0:0.0	.	442	Q6MZW2	FSTL4_HUMAN	P	442;273	ENSP00000265342:L442P	ENSP00000265342:L442P	L	-	2	0	FSTL4	132587795	1.000000	0.71417	1.000000	0.80357	0.987000	0.75469	8.800000	0.91900	2.326000	0.78906	0.533000	0.62120	CTG		TCGA-2J-AABO-01A-21D-A40W-08	FSTL4-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000370212.1	1	0	0	10	128	0	36	0	3.540391e-02	0	4	0	36	2		0	0	0	0	0	2	1	0.997118	10	127	0	34	2								-5.227649	1	1	0	0		1	1	2	3	1.864899	1	0.240000	3.570000	0.321429	0.690000	0.360000	1.000000	1.000000	0.709615	0.690000	0	5.100000e-01	9.200000e-01
MCTP1	79772	broad.mit.edu	37	5	94114845	94114845	+	Silent	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr5:94114845G>A	ENST00000515393.1	-	19	2579	c.2580C>T	c.(2578-2580)gaC>gaT	p.D860D	MCTP1_ENST00000505078.1_Silent_p.D376D|MCTP1_ENST00000429576.2_Silent_p.D553D|MCTP1_ENST00000514040.1_5'UTR|MCTP1_ENST00000312216.8_Silent_p.D639D	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1			41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)			CTTCTTCCTCGTCCTCTAGCA	0.423000																								0							SO:0001819	synonymous_variant			ENST00000515393.1	1	1	hg19	CCDS34203.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	MCTP1-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000370280.3	1	0	1	75	275	0	58	0	8.609950e-01	1	14	0	58	2		0	0	0	0	0	2	1	1.000000	75	270	0	55	2								-20.000000	1	1	121412	11	42	1	1	2	3	1.864899	1	0.240000	3.570000	0.321429	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
BCLAF1	9774	broad.mit.edu	37	6	136590607	136590607	+	Silent	SNP	A	A	G			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr6:136590607A>G	ENST00000531224.1	-	9	2439	c.2187T>C	c.(2185-2187)gaT>gaC	p.D729D	BCLAF1_ENST00000527536.1_Silent_p.D729D|BCLAF1_ENST00000353331.4_Silent_p.D727D|BCLAF1_ENST00000527759.1_Silent_p.D727D|BCLAF1_ENST00000530767.1_Silent_p.D556D|BCLAF1_ENST00000392348.2_Silent_p.D727D|BCLAF1_ENST00000031135.9_5'Flank|BCLAF1_ENST00000529917.1_5'UTR	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1			9	Colorectal(23;0.24)				ATTCCTTGTAATCTTTTGGAG	0.363000													Colon(142;1534 1789 5427 7063 28491)											0							SO:0001819	synonymous_variant			ENST00000531224.1	0	1	hg19	CCDS5177.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	BCLAF1-003	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000042375.2	1	0	0	15	331	0	78	0	3.340204e-01	0	26	0	78	2		0	0	0	0	0	2	1	0.999812	10	316	0	76	2								-16.617250	1	1	0	0		1	0	2	2	1.650164	1	0.240000	3.570000	0.240000	0.360000	0.210000	0.560000	0.360000	0.379633	0.360000	0	2.800000e-01	4.700000e-01
ABCC10	89845	broad.mit.edu	37	6	43406443	43406443	+	Silent	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr6:43406443C>T	ENST00000372530.4	+	8	2252	c.2037C>T	c.(2035-2037)acC>acT	p.T679T	ABCC10_ENST00000244533.3_Silent_p.T651T	NM_001198934.1	NP_001185863.1	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10			56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)	Cyclosporine(DB00091)|Cytarabine(DB00987)|Daunorubicin(DB00694)|Docetaxel(DB01248)|Doxorubicin(DB00997)|Estradiol(DB00783)|Etoposide(DB00773)|Gemcitabine(DB00441)|Methotrexate(DB00563)|Paclitaxel(DB01229)|Sildenafil(DB00203)|Tenofovir(DB00300)|Verapamil(DB00661)|Vincristine(DB00541)	AGTTTGCCACCATCCGAGACA	0.592000																								0							SO:0001819	synonymous_variant			ENST00000372530.4	1	1	hg19	CCDS56430.1																																																																																				TCGA-2J-AABO-01A-21D-A40W-08	ABCC10-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000040603.2	1	0	0	36	316	0	68	0	2.015547e-01	0	8	0	68	2		0	0	0	0	0	2	1	1.000000	36	310	0	65	2								-3.142702	1	1	0	0		1	1	2	3	1.842370	1	0.240000	3.570000	0.321429	0.950000	0.680000	1.000000	1.000000	0.922917	0.950000	1	8.100000e-01	1
NOS3	4846	broad.mit.edu	37	7	150698985	150698985	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr7:150698985G>A	ENST00000484524.1	+	12	1579	c.1579G>A	c.(1579-1581)Gag>Aag	p.E527K	NOS3_ENST00000297494.3_Missense_Mutation_p.E527K|NOS3_ENST00000467517.1_Missense_Mutation_p.E527K|NOS3_ENST00000461406.1_Missense_Mutation_p.E321K	NM_001160111.1	NP_001153583.1	P60323	NANO3_HUMAN	nitric oxide synthase 3 (endothelial cell)			50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)		GTATGGCTCCGAGACCGGCCG	0.652000																								0							SO:0001583	missense			ENST00000484524.1	1	1	hg19	CCDS55182.1	.	.	.	.	.	.	.	.	.	.	G	23.2	4.388389	0.82902	.	.	ENSG00000164867	ENST00000297494;ENST00000461406;ENST00000484524;ENST00000467517	T;T;T;T	0.74842	-0.88;-0.88;-0.88;-0.88	4.8	4.8	0.61643	Flavodoxin/nitric oxide synthase (2);	0.000000	0.56097	D	0.000038	D	0.89434	0.6714	M	0.93898	3.47	0.54753	D	0.999983	D;D;D;D;D	0.89917	1.0;1.0;1.0;1.0;1.0	D;D;D;D;D	0.97110	0.987;0.987;0.994;1.0;0.998	D	0.92206	0.5772	10	0.87932	D	0	-6.0588	15.7394	0.77876	0.0:0.0:1.0:0.0	.	527;527;527;321;527	A0S0A6;E9PFR2;A0S0A8;E7ESA7;P29474	.;.;.;.;NOS3_HUMAN	K	527;321;527;527	ENSP00000297494:E527K;ENSP00000417143:E321K;ENSP00000420215:E527K;ENSP00000420551:E527K	ENSP00000297494:E527K	E	+	1	0	NOS3	150329918	1.000000	0.71417	0.940000	0.37924	0.308000	0.27856	9.261000	0.95576	2.376000	0.81061	0.655000	0.94253	GAG		TCGA-2J-AABO-01A-21D-A40W-08	NOS3-004	NOVEL	basic|exp_conf|CCDS	protein_coding	protein_coding	OTTHUMT00000351550.1	1	0	1	69	246	0	85	0	1.256521e-01	0	3	0	85	2		0	0	0	0	0	2	1	1.000000	66	240	0	84	2								-20.000000	1	1	121394	3	34	1	2	2	4	2.083680	0	0.240000	3.570000	0.387097	0.990000	0.990000	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
CSMD1	64478	broad.mit.edu	37	8	2813124	2813124	+	Silent	SNP	C	C	T	rs147768119	by1000genomes	TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr8:2813124C>T	ENST00000520002.1	-	65	10539	c.9984G>A	c.(9982-9984)tcG>tcA	p.S3328S	CSMD1_ENST00000542608.1_Silent_p.S3150S|CSMD1_ENST00000602557.1_Silent_p.S3328S|CSMD1_ENST00000537824.1_Silent_p.S3327S|CSMD1_ENST00000400186.3_Silent_p.S3151S|CSMD1_ENST00000602723.1_Silent_p.S3151S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1			25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)			TACACACAGGCGACTTTCCTG	0.488000																								0							SO:0001819	synonymous_variant			ENST00000520002.1	1	0	hg19		7	0.003205128205128205	5	0.01016260162601626	2	0.0055248618784530384	0	0.0	0	0.0	C	3.359	-0.130848	0.06753	0.002703	0.0	ENSG00000183117	ENST00000335551	.	.	.	5.64	-6.09	0.02145	.	.	.	.	.	T	0.28001	0.0690	.	.	.	0.80722	D	1	.	.	.	.	.	.	T	0.35351	-0.9792	4	.	.	.	.	1.9357	0.03336	0.1018:0.2364:0.2112:0.4506	.	.	.	.	T	2745	.	.	A	-	1	0	CSMD1	2800531	0.007000	0.16637	0.831000	0.32960	0.381000	0.30169	-1.266000	0.02842	-1.299000	0.02344	-0.691000	0.03719	GCC		TCGA-2J-AABO-01A-21D-A40W-08	CSMD1-001	KNOWN	basic|appris_candidate_longest	protein_coding	protein_coding	OTTHUMT00000374500.2	1	0	0	20	188	0	46		0	0	0	0	46	2		0	0	0	0	0	2	1	0.999996	20	185	0	44	2								-7.426567	1	1	120966	55	49	1	1	2	3	1.922277	0	0.240000	3.570000	0.321429	0.900000	0.570000	1.000000	1.000000	0.878260	0.900000	1	7.200000e-01	1
MOS	4342	broad.mit.edu	37	8	57026538	57026538	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr8:57026538G>A	ENST00000311923.1	-	1	3	c.4C>T	c.(4-6)Ccc>Tcc	p.P2S		NM_005372.1	NP_005363.1	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene homolog			22			Epithelial(17;0.00117)|all cancers(17;0.00879)		AGGGGCGAGGGCATCGCACTT	0.632000													Esophageal Squamous(124;373 2870 4778)											0							SO:0001583	missense			ENST00000311923.1	0	1	hg19	CCDS6164.1	.	.	.	.	.	.	.	.	.	.	G	19.53	3.845672	0.71603	.	.	ENSG00000172680	ENST00000311923	D	0.82081	-1.57	5.14	5.14	0.70334	.	0.000000	0.64402	U	0.000001	D	0.90940	0.7152	M	0.76574	2.34	0.80722	D	1	D	0.89917	1.0	D	0.77004	0.989	D	0.92023	0.5627	10	0.87932	D	0	.	18.222	0.89904	0.0:0.0:1.0:0.0	.	2	P00540	MOS_HUMAN	S	2	ENSP00000310722:P2S	ENSP00000310722:P2S	P	-	1	0	MOS	57189092	1.000000	0.71417	0.998000	0.56505	0.094000	0.18550	9.169000	0.94788	2.387000	0.81309	0.557000	0.71058	CCC		TCGA-2J-AABO-01A-21D-A40W-08	MOS-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000378174.1	1	0	0	6	98	0	20		0	0	0	0	20	2		0	0	0	0	0	2	1	0.965404	6	97	0	19	2								-10.078070	1	1	120526	1	25	1	2	2	4	2.047432	0	0.240000	3.570000	0.377457	0.640000	0.270000	1.000000	1.000000	0.669987	0.640000	0	4.200000e-01	9.800000e-01
GABBR2	9568	broad.mit.edu	37	9	101216358	101216358	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr9:101216358G>A	ENST00000259455.2	-	7	1600	c.1141C>T	c.(1141-1143)Cgg>Tgg	p.R381W		NM_005458.7	NP_005449.5	O75899	GABR2_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 2	p.R381W(1)	NOTCH1_ENST00000277541/GABBR2(2)	49		Acute lymphoblastic leukemia(62;0.0527)		Baclofen(DB00181)	CGCTGGTGCCGGCTGCTGGCA	0.607000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000259455.2	1	1	hg19	CCDS6736.1	.	.	.	.	.	.	.	.	.	.	G	19.75	3.886305	0.72410	.	.	ENSG00000136928	ENST00000259455	D	0.83914	-1.78	5.79	3.75	0.43078	Extracellular ligand-binding receptor (1);	0.196584	0.45361	D	0.000367	D	0.84977	0.5592	L	0.46157	1.445	0.53005	D	0.99996	D	0.69078	0.997	P	0.58077	0.832	D	0.86335	0.1701	10	0.87932	D	0	.	12.3524	0.55155	0.0:0.0:0.6388:0.3612	.	381	O75899	GABR2_HUMAN	W	381	ENSP00000259455:R381W	ENSP00000259455:R381W	R	-	1	2	GABBR2	100256179	0.998000	0.40836	1.000000	0.80357	0.993000	0.82548	1.287000	0.33284	1.400000	0.46741	0.650000	0.86243	CGG		TCGA-2J-AABO-01A-21D-A40W-08	GABBR2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000053373.1	1	0	1	32	201	0	55		0	0	0	0	55	2		0	0	0	0	0	2	1	1.000000	32	200	0	53	2								-15.326930	1	1	121412	1	30	1	1	2	3	1.846996	1	0.240000	3.570000	0.317774	0.990000	0.900000	1.000000	1.000000	0.994600	0.990000	1	9.900000e-01	1
DDX31	64794	broad.mit.edu	37	9	135523898	135523898	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr9:135523898G>A	ENST00000372159.3	-	10	1247	c.1096C>T	c.(1096-1098)Cgc>Tgc	p.R366C	DDX31_ENST00000438527.3_Missense_Mutation_p.R237C|DDX31_ENST00000372153.1_Missense_Mutation_p.R366C|DDX31_ENST00000310532.2_Missense_Mutation_p.R366C	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31			27					TCCACCAGGCGTCCAGGAGTT	0.413000																								0							SO:0001583	missense			ENST00000372159.3	0	1	hg19	CCDS6951.1	.	.	.	.	.	.	.	.	.	.	G	25.8	4.672307	0.88348	.	.	ENSG00000125485	ENST00000372159;ENST00000372155;ENST00000372153;ENST00000438527;ENST00000310532	T;T;T;T	0.54479	2.09;0.57;2.09;0.57	6.17	6.17	0.99709	DEAD-like helicase (2);DNA/RNA helicase, DEAD/DEAH box type, N-terminal (1);	0.000000	0.85682	D	0.000000	D	0.82664	0.5086	H	0.97940	4.11	0.80722	D	1	D;D	0.89917	1.0;1.0	D;D	0.97110	1.0;1.0	D	0.87906	0.2694	10	0.87932	D	0	-15.9721	14.6754	0.68975	0.0:0.0:0.8551:0.1449	.	366;366	Q9H8H2-2;Q9H8H2	.;DDX31_HUMAN	C	366;366;366;237;366	ENSP00000361232:R366C;ENSP00000361226:R366C;ENSP00000387730:R237C;ENSP00000310539:R366C	ENSP00000310539:R366C	R	-	1	0	DDX31	134513719	1.000000	0.71417	0.537000	0.28052	0.995000	0.86356	7.100000	0.76989	2.941000	0.99782	0.655000	0.94253	CGC		TCGA-2J-AABO-01A-21D-A40W-08	DDX31-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000054794.1	0	0	0	11	645	0	138	0	7.038613e-03	0	7	0	138	2		0	0	0	0	0	2	1	0.998185	11	634	0	137	2								-2.889608	1	1	121412	5	37	1	1	2	3	1.835172	1	0.240000	3.570000	0.319971	0.160000	0.070000	0.290000	0.150000	0.177437	0.160000	0	1.100000e-01	2.200000e-01
OLFM1	10439	broad.mit.edu	37	9	138011686	138011686	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr9:138011686G>A	ENST00000371793.3	+	6	1371	c.1120G>A	c.(1120-1122)Gct>Act	p.A374T	OLFM1_ENST00000371796.3_Missense_Mutation_p.A347T|OLFM1_ENST00000252854.4_Missense_Mutation_p.A356T	NM_001282611.1	NP_001269540.1	Q99784	NOE1_HUMAN	olfactomedin 1			21		Myeloproliferative disorder(178;0.0333)			CAACCAGAACGCTGGCAACAT	0.627000																								0							SO:0001583	missense			ENST00000371793.3	1	1	hg19		.	.	.	.	.	.	.	.	.	.	G	24.8	4.567026	0.86439	.	.	ENSG00000130558	ENST00000252854;ENST00000371796;ENST00000371793	D;D;D	0.88896	-2.44;-2.44;-2.44	4.79	4.79	0.61399	Olfactomedin-like (3);Quinonprotein alcohol dehydrogenase-like (1);	0.000000	0.85682	D	0.000000	D	0.92348	0.7572	L	0.42686	1.345	0.80722	D	1	D;D	0.89917	1.0;1.0	D;D	0.87578	0.997;0.998	D	0.93259	0.6641	10	0.66056	D	0.02	.	17.8435	0.88722	0.0:0.0:1.0:0.0	.	374;356	Q99784;Q6IMJ8	NOE1_HUMAN;.	T	356;347;374	ENSP00000252854:A356T;ENSP00000360861:A347T;ENSP00000360858:A374T	ENSP00000252854:A356T	A	+	1	0	OLFM1	137151507	1.000000	0.71417	1.000000	0.80357	0.672000	0.39443	9.571000	0.98176	2.214000	0.71695	0.561000	0.74099	GCT		TCGA-2J-AABO-01A-21D-A40W-08	OLFM1-004	KNOWN	basic|appris_principal	protein_coding	protein_coding	OTTHUMT00000054974.1	1	0	1	22	128	0	45	0	4.027173e-01	0	9	0	45	2		0	0	0	0	0	2	1	0.999999	21	123	0	44	2								-20.000000	1	1	0	0		1	1	2	3	1.835172	1	0.240000	3.570000	0.319971	0.990000	0.900000	1.000000	1.000000	0.994459	0.990000	1	9.900000e-01	1
KCNT1	57582	broad.mit.edu	37	9	138670646	138670646	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chr9:138670646G>A	ENST00000263604.3	+	23	2650	c.2650G>A	c.(2650-2652)Gtc>Atc	p.V884I	KCNT1_ENST00000486577.2_Missense_Mutation_p.V862I|KCNT1_ENST00000488444.2_Missense_Mutation_p.V884I|KCNT1_ENST00000298480.5_Missense_Mutation_p.V903I|KCNT1_ENST00000371757.2_Missense_Mutation_p.V903I|KCNT1_ENST00000491806.2_Missense_Mutation_p.V870I|KCNT1_ENST00000487664.1_Missense_Mutation_p.V858I|KCNT1_ENST00000490355.2_Missense_Mutation_p.V882I			Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1			50		Myeloproliferative disorder(178;0.0821)			CAAGACCATCGTCAACGTGCA	0.637000																								0							SO:0001583	missense			ENST00000263604.3	1	1	hg19		.	.	.	.	.	.	.	.	.	.	G	23.9	4.471882	0.84533	2.27E-4	0.0	ENSG00000107147	ENST00000487664;ENST00000298480;ENST00000371757;ENST00000486577;ENST00000491806;ENST00000488444;ENST00000490355;ENST00000263604	T;T;T;T	0.77877	-1.13;-1.13;-1.13;-1.13	4.5	4.5	0.54988	.	0.000000	0.64402	U	0.000001	D	0.84243	0.5429	L	0.45581	1.43	0.58432	D	0.999999	D;D;D;D	0.89917	1.0;0.989;0.994;0.989	D;P;P;P	0.85130	0.997;0.652;0.677;0.578	D	0.83797	0.0234	10	0.37606	T	0.19	-40.5009	17.1945	0.86888	0.0:0.0:1.0:0.0	.	870;903;858;884	C9JYL2;B9EGP2;G5E9V0;Q5JUK3	.;.;.;KCNT1_HUMAN	I	858;903;903;862;870;884;882;884	ENSP00000417851:V858I;ENSP00000298480:V903I;ENSP00000360822:V903I;ENSP00000263604:V884I	ENSP00000263604:V884I	V	+	1	0	KCNT1	137810467	1.000000	0.71417	1.000000	0.80357	0.997000	0.91878	9.563000	0.98148	2.024000	0.59613	0.557000	0.71058	GTC		TCGA-2J-AABO-01A-21D-A40W-08	KCNT1-201	KNOWN	basic|appris_candidate	protein_coding	protein_coding		1	0	1	20	175	0	37		0	0	0	0	37	2		0	0	0	0	0	2	1	0.999995	20	169	0	36	2								-9.246055	1	1	121408	1	30	1	1	2	3	1.856712	1	0.240000	3.570000	0.311095	0.980000	0.610000	1.000000	1.000000	0.914142	0.980000	1	7.800000e-01	1
TLR8	51311	broad.mit.edu	37	X	12939864	12939864	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chrX:12939864G>A	ENST00000218032.6	+	2	2792	c.2705G>A	c.(2704-2706)cGc>cAc	p.R902H	TLR8_ENST00000311912.5_Missense_Mutation_p.R920H	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8			50				Imiquimod(DB00724)	AATGAGCTGCGCTACCACCTT	0.478000																								0							SO:0001583	missense			ENST00000218032.6	1	1	hg19	CCDS14152.1	.	.	.	.	.	.	.	.	.	.	G	18.35	3.604067	0.66445	.	.	ENSG00000101916	ENST00000218032;ENST00000311912	T;T	0.08102	3.13;3.13	5.97	5.1	0.69264	Toll/interleukin-1 receptor homology (TIR) domain (3);	0.000000	0.38959	N	0.001508	T	0.26702	0.0653	M	0.78637	2.42	0.44595	D	0.997569	D;D	0.89917	1.0;1.0	D;D	0.81914	0.995;0.995	T	0.01215	-1.1416	10	0.66056	D	0.02	.	8.7627	0.34685	0.08:0.0:0.7253:0.1947	.	902;920	Q9NR97;D1CS70	TLR8_HUMAN;.	H	902;920	ENSP00000218032:R902H;ENSP00000312082:R920H	ENSP00000218032:R902H	R	+	2	0	TLR8	12849785	1.000000	0.71417	1.000000	0.80357	0.975000	0.68041	7.451000	0.80668	1.282000	0.44496	0.600000	0.82982	CGC		TCGA-2J-AABO-01A-21D-A40W-08	TLR8-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000055784.2	1	0	1	67	311	0	93		0	0	0	0	93	2		0	0	0	0	0	2	1	1.000000	67	307	0	92	2								-20.000000	1	1	0	0		1	0	1	1			0.240000	3.570000	0.240000	0.730000	0.580000	0.890000	0.730000	0.739008	0.730000	0	6.500000e-01	8.200000e-01
MAP7D3	79649	broad.mit.edu	37	X	135314079	135314079	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chrX:135314079G>A	ENST00000316077.9	-	8	1257	c.1037C>T	c.(1036-1038)tCg>tTg	p.S346L	MAP7D3_ENST00000370663.5_Missense_Mutation_p.S328L|MAP7D3_ENST00000495432.1_5'Flank|MAP7D3_ENST00000370661.1_Missense_Mutation_p.S311L	NM_024597.3	NP_078873.2	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3			44	Acute lymphoblastic leukemia(192;0.000127)				CACCACAGGCGACACGTCCAC	0.572000																								0							SO:0001583	missense			ENST00000316077.9	1	1	hg19	CCDS44004.1	.	.	.	.	.	.	.	.	.	.	G	10.41	1.341803	0.24339	.	.	ENSG00000129680	ENST00000370661;ENST00000316077;ENST00000370663;ENST00000370660	T;T;T;T	0.08102	3.13;3.13;3.13;3.13	4.0	-2.91	0.05631	.	.	.	.	.	T	0.04452	0.0122	L	0.28192	0.835	0.09310	N	1	B;B;B;B	0.30033	0.266;0.02;0.069;0.208	B;B;B;B	0.17979	0.011;0.011;0.004;0.02	T	0.32981	-0.9886	9	0.42905	T	0.14	2.4003	4.2005	0.10464	0.4556:0.0:0.2903:0.254	.	328;305;346;311	B4DWD2;Q8IWC1-2;Q8IWC1;Q8IWC1-3	.;.;MA7D3_HUMAN;.	L	311;346;328;305	ENSP00000359695:S311L;ENSP00000318086:S346L;ENSP00000359697:S328L;ENSP00000359694:S305L	ENSP00000318086:S346L	S	-	2	0	MAP7D3	135141745	0.000000	0.05858	0.000000	0.03702	0.000000	0.00434	0.456000	0.21859	-1.115000	0.02973	-0.268000	0.10319	TCG		TCGA-2J-AABO-01A-21D-A40W-08	MAP7D3-001	PUTATIVE	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000058487.2	1	0	1	134	146	0	67	0	8.649807e-01	0	6	0	67	2		0	0	0	0	0	2	1	1.000000	134	145	0	66	2								-20.000000	1	1	0	0		1	0	1	1			0.240000	3.570000	0.240000	0.990000	0.950000	1.000000	0.990000	0.992381	0.990000	1	9.700000e-01	1
MAGEB2	4113	broad.mit.edu	37	X	30236753	30236753	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chrX:30236753G>A	ENST00000378988.4	+	2	157	c.56G>A	c.(55-57)cGa>cAa	p.R19Q		NM_002364.4	NP_002355.2	O15479	MAGB2_HUMAN	melanoma antigen family B, 2			23					CGCAAGGCCCGAGATGAGACC	0.552000																								0							SO:0001583	missense			ENST00000378988.4	0	1	hg19	CCDS14219.1	1	6.027727546714888E-4	1	0.0020325203252032522	0	0.0	0	0.0	0	0.0	G	10.12	1.263218	0.23051	.	.	ENSG00000099399	ENST00000378988	T	0.04015	3.73	3.43	-0.481	0.12082	Melanoma associated antigen, MAGE, N-terminal (1);	1.269310	0.05610	N	0.577923	T	0.03348	0.0097	L	0.38733	1.17	0.09310	N	1	P	0.46277	0.875	B	0.33960	0.173	T	0.45906	-0.9229	10	0.14656	T	0.56	.	6.2626	0.20910	0.528:0.0:0.472:0.0	.	19	O15479	MAGB2_HUMAN	Q	19	ENSP00000368273:R19Q	ENSP00000368273:R19Q	R	+	2	0	MAGEB2	30146674	0.000000	0.05858	0.000000	0.03702	0.007000	0.05969	0.141000	0.16076	-0.251000	0.09542	0.513000	0.50165	CGA		TCGA-2J-AABO-01A-21D-A40W-08	MAGEB2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000056157.1	0	0	0	4	65	0	9		0	0	0	0	9	2		0	0	0	0	0	2	1	0.885455	4	63	0	8	2								-4.369902	1	1	121406	2	35	1	0	1	1			0.240000	3.570000	0.240000	0.250000	0.080000	0.530000	0.230000	0.280140	0.250000	0	1.500000e-01	3.900000e-01
PCDH11X	27328	broad.mit.edu	37	X	91090535	91090535	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABO-01A-21D-A40W-08	TCGA-2J-AABO-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16470dac-103c-4ecc-8407-af967f95b1a8	f915639e-4fa7-4f9e-a5ab-73747b07fae2	g.chrX:91090535C>T	ENST00000373094.1	+	1	877	c.32C>T	c.(31-33)gCg>gTg	p.A11V	PCDH11X_ENST00000298274.8_Missense_Mutation_p.A11V|PCDH11X_ENST00000361724.1_Missense_Mutation_p.A11V|PCDH11X_ENST00000373088.1_Missense_Mutation_p.A11V|PCDH11X_ENST00000395337.2_Missense_Mutation_p.A11V|PCDH11X_ENST00000504220.2_Missense_Mutation_p.A11V|PCDH11X_ENST00000361655.2_Missense_Mutation_p.A11V|PCDH11X_ENST00000406881.1_Missense_Mutation_p.A11V|PCDH11X_ENST00000373097.1_Missense_Mutation_p.A11V	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked			159					TACATTTTCGCGGTCCTGCTA	0.493000													NSCLC(38;925 1092 2571 38200 45895)											0							SO:0001583	missense			ENST00000373094.1	1	1	hg19	CCDS14461.1	.	.	.	.	.	.	.	.	.	.	C	10.57	1.387562	0.25031	.	.	ENSG00000102290	ENST00000395337;ENST00000373094;ENST00000373097;ENST00000361724;ENST00000373088;ENST00000504220;ENST00000361655;ENST00000406881;ENST00000356934;ENST00000298274	T;T;T;T;T;T;T;T;T	0.51071	0.73;0.76;0.77;0.72;0.78;0.77;0.75;0.78;0.78	3.93	3.93	0.45458	.	0.251193	0.32769	N	0.005671	T	0.38134	0.1029	L	0.29908	0.895	0.30046	N	0.812228	P;B;P;P;P;P;B;P	0.44139	0.703;0.296;0.827;0.827;0.827;0.735;0.28;0.526	B;B;B;B;B;B;B;B	0.43155	0.168;0.055;0.41;0.41;0.41;0.233;0.047;0.047	T	0.30621	-0.9972	10	0.23891	T	0.37	.	14.4725	0.67526	0.0:1.0:0.0:0.0	.	11;11;11;11;11;11;11;11	Q9BZA7-6;Q9BZA7-5;Q9BZA7-4;Q9BZA7-8;Q9BZA7-3;Q9BZA7;Q9BZA7-7;Q9BZA7-2	.;.;.;.;.;PC11X_HUMAN;.;.	V	11	ENSP00000378746:A11V;ENSP00000362186:A11V;ENSP00000362189:A11V;ENSP00000355040:A11V;ENSP00000362180:A11V;ENSP00000423762:A11V;ENSP00000355105:A11V;ENSP00000384758:A11V;ENSP00000298274:A11V	ENSP00000298274:A11V	A	+	2	0	PCDH11X	90977191	1.000000	0.71417	1.000000	0.80357	0.369000	0.29798	3.861000	0.56002	1.935000	0.56089	0.415000	0.27848	GCG		TCGA-2J-AABO-01A-21D-A40W-08	PCDH11X-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000057436.1	1	0	1	25	179	0	56		0	0	0	0	56	2		0	0	0	0	0	2	1	1.000000	25	178	0	54	2								-3.143671	1	1	0	0		1	0	1	1			0.240000	3.570000	0.240000	0.500000	0.340000	0.700000	0.500000	0.517762	0.500000	0	4.100000e-01	6.100000e-01
