Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	ACHILLES_Lineage_Results_Top_Genes	CGC_CancerGermlineMut	CGC_CancerMolecularGenetics	CGC_CancerSomaticMut	CGC_CancerSyndrome	CGC_Chr	CGC_ChrBand	CGC_GeneID	CGC_Name	CGC_OtherGermlineMut	CGC_TissueType	COSMIC_n_overlapping_mutations	COSMIC_overlapping_mutation_descriptions	ClinVar_ASSEMBLY	ClinVar_HGMD_ID	ClinVar_SYM	ClinVar_TYPE	ClinVar_rs	Ensembl_so_accession	Ensembl_so_term	Familial_Cancer_Genes_Reference	Familial_Cancer_Genes_Synonym	annotation_transcript	bcgsc	broad	build	ccds_id	dbNSFP_1000Gp1_AC	dbNSFP_1000Gp1_AF	dbNSFP_1000Gp1_AFR_AC	dbNSFP_1000Gp1_AFR_AF	dbNSFP_1000Gp1_AMR_AC	dbNSFP_1000Gp1_AMR_AF	dbNSFP_1000Gp1_ASN_AC	dbNSFP_1000Gp1_ASN_AF	dbNSFP_1000Gp1_EUR_AC	dbNSFP_1000Gp1_EUR_AF	dbNSFP_Ancestral_allele	dbNSFP_CADD_phred	dbNSFP_CADD_raw	dbNSFP_CADD_raw_rankscore	dbNSFP_ESP6500_AA_AF	dbNSFP_ESP6500_EA_AF	dbNSFP_Ensembl_geneid	dbNSFP_Ensembl_transcriptid	dbNSFP_FATHMM_pred	dbNSFP_FATHMM_rankscore	dbNSFP_FATHMM_score	dbNSFP_GERP_NR	dbNSFP_GERP_RS	dbNSFP_GERP_RS_rankscore	dbNSFP_Interpro_domain	dbNSFP_LRT_Omega	dbNSFP_LRT_converted_rankscore	dbNSFP_LRT_pred	dbNSFP_LRT_score	dbNSFP_LR_pred	dbNSFP_LR_rankscore	dbNSFP_LR_score	dbNSFP_MutationAssessor_pred	dbNSFP_MutationAssessor_rankscore	dbNSFP_MutationAssessor_score	dbNSFP_MutationTaster_converted_rankscore	dbNSFP_MutationTaster_pred	dbNSFP_MutationTaster_score	dbNSFP_Polyphen2_HDIV_pred	dbNSFP_Polyphen2_HDIV_rankscore	dbNSFP_Polyphen2_HDIV_score	dbNSFP_Polyphen2_HVAR_pred	dbNSFP_Polyphen2_HVAR_rankscore	dbNSFP_Polyphen2_HVAR_score	dbNSFP_RadialSVM_pred	dbNSFP_RadialSVM_rankscore	dbNSFP_RadialSVM_score	dbNSFP_Reliability_index	dbNSFP_SIFT_converted_rankscore	dbNSFP_SIFT_pred	dbNSFP_SIFT_score	dbNSFP_SLR_test_statistic	dbNSFP_SiPhy_29way_logOdds	dbNSFP_SiPhy_29way_logOdds_rankscore	dbNSFP_SiPhy_29way_pi	dbNSFP_UniSNP_ids	dbNSFP_Uniprot_aapos	dbNSFP_Uniprot_acc	dbNSFP_Uniprot_id	dbNSFP_aaalt	dbNSFP_aapos	dbNSFP_aapos_FATHMM	dbNSFP_aapos_SIFT	dbNSFP_aaref	dbNSFP_cds_strand	dbNSFP_codonpos	dbNSFP_folddegenerate	dbNSFP_genename	dbNSFP_hg18_pos1coor	dbNSFP_phastCons100way_vertebrate	dbNSFP_phastCons100way_vertebrate_rankscore	dbNSFP_phastCons46way_placental	dbNSFP_phastCons46way_placental_rankscore	dbNSFP_phastCons46way_primate	dbNSFP_phastCons46way_primate_rankscore	dbNSFP_phyloP100way_vertebrate	dbNSFP_phyloP100way_vertebrate_rankscore	dbNSFP_phyloP46way_placental	dbNSFP_phyloP46way_placental_rankscore	dbNSFP_phyloP46way_primate	dbNSFP_phyloP46way_primate_rankscore	dbNSFP_refcodon	entrez_gene_id	external_id_capture	gencode_transcript_name	gencode_transcript_status	gencode_transcript_tags	gencode_transcript_type	gene_type	havana_transcript	hgsc	igv_bad	ucsc	t_alt_count	t_ref_count	n_alt_count	n_ref_count	validation_judgement_rna	validation_power_rna	validation_tumor_alt_count_rna	validation_tumor_ref_count_rna	validation_normal_alt_count_rna	validation_normal_ref_count_rna	min_val_count_rna	validation_judgement_targeted	validation_power_targeted	validation_tumor_alt_count_targeted	validation_tumor_ref_count_targeted	validation_normal_alt_count_targeted	validation_normal_ref_count_targeted	min_val_count_targeted	validation_judgement_localAssembly	validation_power_localAssembly	t_alt_count_localAssembly	t_ref_count_localAssembly	n_alt_count_localAssembly	n_ref_count_localAssembly	min_val_count_localAssembly	validation_judgement_KRAS	validation_power_KRAS	t_alt_count_KRAS	t_ref_count_KRAS	n_alt_count_KRAS	n_ref_count_KRAS	min_val_count_KRAS	pon_loglike	pon_pass_loglike	localAssembly_detected	ExAC_AN	ExAC_AC	ExAC_LQ	passExAC	SCNA_NA	SCNA_NB	SCNA_q_hat	SCNA_tau	IS_SCNA	purity	ploidy	dna_fraction_in_tumor	CCF_hat	CCF_CI95_low	CCF_CI95_high	CCF_mode	CCF_mean	CCF_median	clonal	CCF_CI_low	CCF_CI_high
RBP3	5949	broad.mit.edu	37	10	48389530	48389530	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr10:48389530C>T	ENST00000224600.4	-	1	1461	c.1348G>A	c.(1348-1350)Gcc>Acc	p.A450T	AL731561.2_ENST00000581861.1_RNA	NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial			59				Vitamin A(DB00162)	AGGACGGAGGCGTCAGCAAAA	0.617000																								0							SO:0001583	missense			ENST00000224600.4	0	1	hg19	CCDS7218.1	.	.	.	.	.	.	.	.	.	.	C	13.120000	2.143091	0.378250	.	.	ENSG00000107618	ENST00000224600	T	0.64260	-0.09	5.290000	4.290000	0.510400	Interphotoreceptor retinol-binding (2);	0.373325	0.28296	N	0.015863	T	0.67392	0.2888	N	0.21545	0.675	0.339640	D	0.645929	D	0.89917	1.0	D	0.81914	0.995	T	0.76498	-0.2937	10	0.59425	D	0.04	-20.5537	15.734500	0.778310	0.1457:0.8543:0.0:0.0	.	450	P10745	RET3_HUMAN	T	450	ENSP00000224600:A450T	ENSP00000224600:A450T	A	-	1	0	RBP3	48009536	6.040000e-01	0.269320	0.052000	0.191880	0.192000	0.236430	1.115000	0.312090	2.483000	0.838210	0.561000	0.740990	GCC		TCGA-3A-A9IX-01A-11D-A40W-08	RBP3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000047888.1	0	0	0	5	208	0	40		0	0	0	0	40	2		0	0	0	0	0	2	1	9.351301e-01	5	204	0	37	2								-6.695076	1	1	121410	2	32	1	0	0	0	1.974433	0	0.100000	2	0.082569	0.480000	0.180000	0.950000	1.000000	0.516249	0.480000	0	0.310000	0.710000
PLEKHA7	144100	broad.mit.edu	37	11	16872763	16872763	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr11:16872763C>T	ENST00000355661.3	-	8	681	c.671G>A	c.(670-672)cGc>cAc	p.R224H	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.R224H|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.R224H			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	p.R224H(1)		37					GCGGCTTATGCGATCCTCAGG	0.483000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000355661.3	0	1	hg19	CCDS31434.1	.	.	.	.	.	.	.	.	.	.	C	8.567000	0.879093	0.173950	.	.	ENSG00000166689	ENST00000531066;ENST00000355661;ENST00000448080;ENST00000528376	T;T;T;T	0.75821	-0.97;-0.97;-0.97;2.73	5.510000	5.510000	0.819320	Pleckstrin homology-type (1);Pleckstrin homology domain (3);	0.095653	0.64402	D	0.000001	T	0.57021	0.2025	N	0.25094	0.71	0.430470	D	0.994640	B;B	0.23442	0.006;0.085	B;B	0.22880	0.006;0.042	T	0.53725	-0.8398	10	0.02654	T	1	-20.3034	13.678400	0.624690	0.0:0.9262:0.0:0.0738	.	224;224	E9PKC0;Q6IQ23	.;PKHA7_HUMAN	H	224;224;224;118	ENSP00000435389:R224H;ENSP00000347883:R224H;ENSP00000416895:R224H;ENSP00000435806:R118H	ENSP00000347883:R224H	R	-	2	0	PLEKHA7	16829339	1	0.714170	1.000000	0.803570	0.994000	0.842990	3.732000	0.550210	2.605000	0.880820	0.655000	0.942530	CGC		TCGA-3A-A9IX-01A-11D-A40W-08	PLEKHA7-001	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000387242.2	0	0	0	5	320	0	47	0	1.105713e-01	0	30	0	47	2		0	0	0	0	0	2	1	9.349077e-01	5	314	0	47	2								-2.131004	0	1	121412	1	31	1	1	2	3	2.008178	0	0.100000	2	0.107586	0.360000	0.130000	1.000000	0.310000	0.445346	0.360000	0	0.220000	0.670000
PIK3C2A	5286	broad.mit.edu	37	11	17190613	17190613	+	Missense_Mutation	SNP	G	G	C			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr11:17190613G>C	ENST00000265970.7	-	1	675	c.676C>G	c.(676-678)Cta>Gta	p.L226V	PIK3C2A_ENST00000531428.1_Intron|PIK3C2A_ENST00000540361.1_Intron	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha			58					TTGTCAAATAGTTTTGCCATG	0.378000																								0							SO:0001583	missense			ENST00000265970.7	0	1	hg19	CCDS7824.1	.	.	.	.	.	.	.	.	.	.	G	10.190000	1.283209	0.233920	.	.	ENSG00000011405	ENST00000265970;ENST00000544896	T	0.68903	-0.36	5.530000	4.620000	0.575010	.	0.150075	0.46145	N	0.000306	T	0.45458	0.1343	N	0.24115	0.695	0.807220	D	1.000000	P;B	0.36683	0.565;0.058	B;B	0.25884	0.064;0.017	T	0.41395	-0.9511	10	0.30078	T	0.28	-7.8251	10.336300	0.438520	0.0778:0.1736:0.7486:0.0	.	226;226	F5H5W9;O00443	.;P3C2A_HUMAN	V	226	ENSP00000265970:L226V	ENSP00000265970:L226V	L	-	1	2	PIK3C2A	17147189	1	0.714170	1.000000	0.803570	0.983000	0.724000	3.116000	0.503990	1.335000	0.454860	-0.218000	0.125430	CTA		TCGA-3A-A9IX-01A-11D-A40W-08	PIK3C2A-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000387553.1	0	0	0	5	181	0	58	0	1.605707e-01	0	22	0	58	2		0	0	0	0	0	2		0	0	0	0	0	2								-7.283241	1	0	0	0		1	1	2	3	2.008178	0	0.100000	2	0.107586	0.620000	0.230000	1.000000	1.000000	0.656152	0.620000	0	0.380000	1.000000
KCNA4	3739	broad.mit.edu	37	11	30033662	30033662	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr11:30033662C>G	ENST00000328224.6	-	2	1797	c.564G>C	c.(562-564)gaG>gaC	p.E188D	KCNA4_ENST00000526518.1_5'Flank	NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4			78				Dalfampridine(DB06637)	TCATTTGGGTCTCAAAGCGTA	0.493000																								0							SO:0001583	missense			ENST00000328224.6	1	1	hg19	CCDS41629.1	.	.	.	.	.	.	.	.	.	.	C	15.890000	2.967116	0.535070	.	.	ENSG00000182255	ENST00000328224	T	0.78246	-1.16	4.810000	3.880000	0.447660	BTB/POZ-like (1);BTB/POZ fold (2);Potassium channel, voltage dependent, Kv, tetramerisation (1);	0.000000	0.85682	D	0.000000	D	0.83510	0.5270	H	0.96398	3.815	0.584320	D	0.999993	P	0.43938	0.822	B	0.41135	0.348	D	0.85507	0.1195	10	0.87932	D	0	.	9.255200	0.375790	0.0:0.7634:0.0:0.2366	.	188	P22459	KCNA4_HUMAN	D	188	ENSP00000328511:E188D	ENSP00000328511:E188D	E	-	3	2	KCNA4	29990238	1	0.714170	1.000000	0.803570	0.980000	0.705560	1.176000	0.319570	1.001000	0.390760	0.561000	0.740990	GAG		TCGA-3A-A9IX-01A-11D-A40W-08	KCNA4-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000388074.2	0	0	0	11	279	0	49		0	0	0	0	49	2		0	0	0	0	0	2	1	9.983250e-01	11	276	0	48	2								-12.382310	1	1	0	0		1	1	2	3	2.008178	0	0.100000	2	0.107586	0.820000	0.420000	1.000000	1.000000	0.806259	0.820000	0	0.590000	1.000000
OR52M1	119772	broad.mit.edu	37	11	4566917	4566917	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr11:4566917G>A	ENST00000360213.1	+	1	497	c.497G>A	c.(496-498)cGc>cAc	p.R166H		NM_001004137.1	NP_001004137.1	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M, member 1			18		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)			CTGATGATCCGCCTGCGGCTG	0.522000																								0							SO:0001583	missense			ENST00000360213.1	0	1	hg19	CCDS31353.1	.	.	.	.	.	.	.	.	.	.	G	10.310000	1.315172	0.239080	.	.	ENSG00000197790	ENST00000360213	T	0.00137	8.68	4.980000	2.090000	0.271100	GPCR, rhodopsin-like superfamily (1);	0.142760	0.32593	N	0.005884	T	0.00144	0.0004	L	0.55834	1.745	0.093100	N	0.999994	B	0.17852	0.024	B	0.16722	0.016	T	0.40979	-0.9534	10	0.62326	D	0.03	.	4.955300	0.140360	0.3208:0.143:0.5362:0.0	.	166	Q8NGK5	O52M1_HUMAN	H	166	ENSP00000353343:R166H	ENSP00000353343:R166H	R	+	2	0	OR52M1	4523493	0	0.058580	0.122000	0.217670	0.864000	0.494480	-1.025000	0.036000	0.389000	0.250860	-0.133000	0.148550	CGC		TCGA-3A-A9IX-01A-11D-A40W-08	OR52M1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000385847.1	0	0	0	11	424	0	64		0	0	0	0	64	2		0	0	0	0	0	2	1	9.981770e-01	11	415	0	62	2								-2.576260	1	1	121408	7	41	1	1	2	3	2.008178	0	0.100000	2	0.107586	0.550000	0.280000	1.000000	0.500000	0.603431	0.550000	0	0.390000	0.860000
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	targeted			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr12:25398284C>T	ENST00000256078.4	-	2	98	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D	NM_033360.2	NP_203524.1	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)		GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		pancreatic, colorectal, lung, thyroid, AML, others				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)		Dom	yes		12	12p12.1	3845	v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog		L, E, M, O	15813	Substitution - Missense(15812)|Deletion - Frameshift(1)						SO:0001583	missense	Familial Cancer Database	Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS	ENST00000256078.4	1	1	hg19	CCDS8703.1	.	.	.	.	.	.	.	.	.	.	C	23.400000	4.409094	0.833400	.	.	ENSG00000133703	ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131	T;T;T;T	0.78595	-1.19;-1.19;-1.19;-1.19	5.680000	5.680000	0.881260	Small GTP-binding protein domain (1);	0.000000	0.85682	D	0.000000	D	0.85919	0.5809	M	0.91818	3.245	0.807220	D	1.000000	B;P	0.35714	0.385;0.517	B;B	0.41619	0.257;0.361	D	0.87870	0.2670	10	0.87932	D	0	.	18.371900	0.904090	0.0:1.0:0.0:0.0	.	12;12	P01116-2;P01116	.;RASK_HUMAN	D	12	ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D	ENSP00000256078:G12D	G	-	2	0	KRAS	25289551	1	0.714170	1.000000	0.803570	0.998000	0.957120	7.743000	0.850200	2.668000	0.907890	0.563000	0.778840	GGT		TCGA-3A-A9IX-01A-11D-A40W-08	KRAS-004	KNOWN	not_organism_supported|basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000412232.1	0	0	0	6	201	0	74	0	1.835716e-01	0	23	0	74	2	1	9.946456e-01	11	335	0	264	2	1	9.645832e-01	6	199	0	73	2								-3.682514	1	1	121404	2	44	1	1	2	3	2.001631	0	0.100000	2	0.105812	0.640000	0.260000	1.000000	1.000000	0.672448	0.640000	0	0.420000	1.000000
MBNL2	10150	broad.mit.edu	37	13	97999092	97999092	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr13:97999092G>A	ENST00000376673.3	+	5	1356	c.575G>A	c.(574-576)cGg>cAg	p.R192Q	MBNL2_ENST00000445661.2_Intron|MBNL2_ENST00000343600.4_Missense_Mutation_p.R192Q|MBNL2_ENST00000397601.1_Missense_Mutation_p.R192Q|MBNL2_ENST00000345429.6_Missense_Mutation_p.R192Q			Q5VZF2	MBNL2_HUMAN	muscleblind-like splicing regulator 2			17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)		AACTGTGCCCGGGGAGAGACC	0.607000																								0							SO:0001583	missense			ENST00000376673.3	1	1	hg19		.	.	.	.	.	.	.	.	.	.	G	37.000000	6.122025	0.973000	.	.	ENSG00000139793	ENST00000397601;ENST00000343600;ENST00000345429;ENST00000376673	T;T;T;T	0.51071	0.72;0.72;0.72;0.72	5.950000	5.950000	0.964410	Zinc finger, CCCH-type (3);	0.053503	0.85682	D	0.000000	T	0.77308	0.4111	M	0.91090	3.175	0.807220	D	1.000000	D;D;D	0.89917	1.0;0.995;0.997	D;D;P	0.78314	0.991;0.92;0.898	T	0.81185	-0.1048	10	0.87932	D	0	.	20.402400	0.990000	0.0:0.0:1.0:0.0	.	192;192;192	Q5VZF2;A2A3S3;Q5VZF2-2	MBNL2_HUMAN;.;.	Q	192	ENSP00000380726:R192Q;ENSP00000344214:R192Q;ENSP00000267287:R192Q;ENSP00000365861:R192Q	ENSP00000344214:R192Q	R	+	2	0	MBNL2	96797093	1	0.714170	1.000000	0.803570	0.991000	0.796840	9.854000	0.995220	2.827000	0.974450	0.650000	0.862430	CGG		TCGA-3A-A9IX-01A-11D-A40W-08	MBNL2-202	KNOWN	basic	protein_coding	protein_coding		1	0	0	11	207	0	51	1	9.885337e-01	7	139	0	51	2		0	0	0	0	0	2	1	9.981042e-01	11	199	0	50	2								-2.886213	1	1	0	0		1	1	2	3	2.003966	0	0.100000	2	0.106256	0.990000	0.560000	1.000000	1.000000	0.921307	0.990000	1	0.780000	1.000000
TEP1	7011	broad.mit.edu	37	14	20858856	20858856	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr14:20858856G>A	ENST00000262715.5	-	15	2358	c.2318C>T	c.(2317-2319)gCt>gTt	p.A773V	TEP1_ENST00000556935.1_Missense_Mutation_p.A665V	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1			96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)		CCTTTGGCCAGCCAGAGACAG	0.438000																								0							SO:0001583	missense			ENST00000262715.5	0	1	hg19	CCDS9548.1	.	.	.	.	.	.	.	.	.	.	G	4.876000	0.162909	0.092870	.	.	ENSG00000129566	ENST00000262715;ENST00000359243;ENST00000556935	T;T	0.44482	0.96;0.92	4.980000	4.090000	0.477810	.	0.560122	0.19177	N	0.120783	T	0.28928	0.0718	L	0.45137	1.4	0.807220	D	1.000000	B;B;B	0.20261	0.043;0.008;0.025	B;B;B	0.18263	0.021;0.01;0.009	T	0.04855	-1.0922	10	0.07175	T	0.84	-3.4708	8.587500	0.336660	0.1009:0.0:0.8991:0.0	.	665;123;773	G3V5X7;G3V2A4;Q99973	.;.;TEP1_HUMAN	V	773;773;665	ENSP00000262715:A773V;ENSP00000452574:A665V	ENSP00000262715:A773V	A	-	2	0	TEP1	19928696	9.950000e-01	0.382120	0.997000	0.539660	0.950000	0.603330	2.649000	0.466560	2.756000	0.946170	0.655000	0.942530	GCT		TCGA-3A-A9IX-01A-11D-A40W-08	TEP1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000073563.2	0	0	0	5	236	0	46	0	3.210462e-02	0	11	0	46	2		0	0	0	0	0	2	1	9.361185e-01	5	233	0	46	2								-3.105264	1	1	121412	1	27	1	1	2	3	2.006638	0	0.100000	2	0.107143	0.480000	0.170000	1.000000	0.400000	0.544652	0.480000	0	0.300000	0.870000
NOVA1	4857	broad.mit.edu	37	14	27064659	27064659	+	Silent	SNP	A	A	T	rs115769795	byFrequency	TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr14:27064659A>T	ENST00000344429.5	-	2	240	c.237T>A	c.(235-237)acT>acA	p.T79T	NOVA1-AS1_ENST00000547786.1_RNA|NOVA1_ENST00000267422.7_5'UTR|RP11-483C6.1_ENST00000572358.1_RNA|NOVA1_ENST00000465357.2_Silent_p.T79T|NOVA1_ENST00000551754.1_5'UTR|NOVA1_ENST00000574031.1_Silent_p.T79T|NOVA1_ENST00000539517.2_Silent_p.T79T|NOVA1_ENST00000547619.1_Silent_p.T79T	NM_006491.2	NP_006482.1	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1			40					TGGTGGCTCCAGTTTCTTTTT	0.423000																								0							SO:0001819	synonymous_variant			ENST00000344429.5	0	1	hg19	CCDS9635.1																																																																																				TCGA-3A-A9IX-01A-11D-A40W-08	NOVA1-001	KNOWN	basic|exp_conf|CCDS	protein_coding	protein_coding	OTTHUMT00000276557.1	0	0	0	6	465	0	101	0	5.259571e-02	0	24	0	101	2		0	0	0	0	0	2	1	9.642567e-01	6	461	0	98	2								-3.080077	1	1	0	0		1	1	2	3	2.006638	0	0.100000	2	0.107143	0.290000	0.110000	1.000000	0.260000	0.381975	0.290000	0	0.180000	0.510000
PSMC6	5706	broad.mit.edu	37	14	53194224	53194224	+	Silent	SNP	C	C	T			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr14:53194224C>T	ENST00000606149.1	+	14	1075	c.1059C>T	c.(1057-1059)ttC>ttT	p.F353F	PSMC6_ENST00000445930.2_Silent_p.F367F|PSMC6_ENST00000557557.1_3'UTR|STYX_ENST00000354586.4_5'Flank|STYX_ENST00000442123.2_5'Flank	NM_002806.3	NP_002797.3	P62333	PRS10_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 6			19	Breast(41;0.176)				CAGGTATGTTCGCAATTCGTG	0.323000																								0							SO:0001819	synonymous_variant			ENST00000606149.1	0	1	hg19																																																																																					TCGA-3A-A9IX-01A-11D-A40W-08	PSMC6-018	KNOWN	basic|appris_candidate	protein_coding	protein_coding	OTTHUMT00000470741.1	0	0	0	6	173	0	41	1	9.888699e-01	34	214	0	41	2		0	0	0	0	0	2	1	9.619456e-01	6	167	0	40	2								-3.494015	1	1	121408	9	35	1	1	2	3	2.006638	0	0.100000	2	0.107143	0.750000	0.300000	1.000000	1.000000	0.747895	0.750000	0	0.490000	1.000000
KCNH5	27133	broad.mit.edu	37	14	63269191	63269191	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr14:63269191G>A	ENST00000322893.7	-	9	1946	c.1678C>T	c.(1678-1680)Cgc>Tgc	p.R560C	KCNH5_ENST00000420622.2_Missense_Mutation_p.R560C|KCNH5_ENST00000394968.1_Missense_Mutation_p.R502C	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5			99					GCCAAGGCGCGCAGACACCCA	0.512000																								0							SO:0001583	missense			ENST00000322893.7	1	1	hg19	CCDS9756.1	.	.	.	.	.	.	.	.	.	.	G	20.200000	3.948501	0.737870	.	.	ENSG00000140015	ENST00000322893;ENST00000420622;ENST00000394968	D;D;D	0.96940	-4.18;-4.18;-4.18	5.130000	4.220000	0.498570	Cyclic nucleotide-binding-like (1);RmlC-like jelly roll fold (1);Cyclic nucleotide-binding domain (2);	0.000000	0.85682	D	0.000000	D	0.98413	0.9472	M	0.91038	3.17	0.807220	D	1.000000	D;D;D	0.89917	1.0;1.0;1.0	D;D;D	0.97110	1.0;1.0;1.0	D	0.99564	1.0969	10	0.87932	D	0	.	15.724200	0.777400	0.0:0.1373:0.8627:0.0	.	502;560;560	Q8NCM2-3;Q8NCM2-2;Q8NCM2	.;.;KCNH5_HUMAN	C	560;560;502	ENSP00000321427:R560C;ENSP00000395439:R560C;ENSP00000378419:R502C	ENSP00000321427:R560C	R	-	1	0	KCNH5	62338944	1	0.714170	0.977000	0.429130	0.897000	0.524650	5.628000	0.677910	1.265000	0.442150	0.563000	0.778840	CGC		TCGA-3A-A9IX-01A-11D-A40W-08	KCNH5-004	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000411747.1	0	0	0	14	342	0	48		0	0	0	0	48	2		0	0	0	0	0	2	1	9.997434e-01	14	337	0	45	2								-3.012310	1	1	0	0		1	1	2	3	2.010425	0	0.100000	2	0.108028	0.840000	0.470000	1.000000	1.000000	0.827074	0.840000	0	0.630000	1.000000
THBS1	7057	broad.mit.edu	37	15	39884787	39884787	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr15:39884787C>T	ENST00000260356.5	+	17	2716	c.2551C>T	c.(2551-2553)Cgc>Tgc	p.R851C	CTD-2033D15.1_ENST00000560769.1_RNA	NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1			53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)			TGACTCAGACCGCATTGGAGA	0.453000																								0							SO:0001583	missense			ENST00000260356.5	0	1	hg19	CCDS32194.1	.	.	.	.	.	.	.	.	.	.	C	22.900000	4.345471	0.820220	.	.	ENSG00000137801	ENST00000260356	D	0.98400	-4.91	5.000000	5.000000	0.665970	.	0.492001	0.15344	N	0.267319	D	0.98510	0.9503	L	0.58101	1.795	0.584320	D	0.999996	B;D	0.89917	0.151;1.0	B;D	0.63381	0.075;0.914	D	0.99748	1.1017	10	0.66056	D	0.02	-5.5658	18.634200	0.913710	0.0:1.0:0.0:0.0	.	766;851	B4E3J7;P07996	.;TSP1_HUMAN	C	851	ENSP00000260356:R851C	ENSP00000260356:R851C	R	+	1	0	THBS1	37672079	9.970000e-01	0.396340	0.999000	0.593770	0.996000	0.888480	6.081000	0.713090	2.474000	0.835620	0.655000	0.942530	CGC		TCGA-3A-A9IX-01A-11D-A40W-08	THBS1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000257831.2	0	0	0	4	94	0	18	1	9.999965e-01	30	1585	0	18	2		0	0	0	0	0	2	1	8.918450e-01	4	94	0	17	2								-4.070278	1	1	0	0		1	0	1	1	1.986317	0	0.100000	2	0.091368	0.820000	0.290000	1.000000	1.000000	0.782319	0.820000	0	0.510000	1.000000
RHBDF1	64285	broad.mit.edu	37	16	108512	108512	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr16:108512G>A	ENST00000262316.6	-	18	2537	c.2395C>T	c.(2395-2397)Cgg>Tgg	p.R799W		NM_022450.3	NP_071895.3	Q96CC6	RHDF1_HUMAN	rhomboid 5 homolog 1 (Drosophila)			18		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)			CAGCGTTTCCGGTACAGGTCG	0.552000																								0							SO:0001583	missense			ENST00000262316.6	1	1	hg19	CCDS32344.1	.	.	.	.	.	.	.	.	.	.	.	15.510000	2.856054	0.513760	.	.	ENSG00000007384	ENST00000262316	T	0.55930	0.49	5.070000	4.110000	0.480880	.	0.052909	0.85682	D	0.000000	T	0.53465	0.1798	M	0.81942	2.565	0.807220	D	1.000000	P	0.51449	0.945	B	0.42188	0.379	T	0.60875	-0.7176	10	0.87932	D	0	-26.6161	8.639200	0.339680	0.0821:0.0:0.7579:0.16	.	799	Q96CC6	RHDF1_HUMAN	W	799	ENSP00000262316:R799W	ENSP00000262316:R799W	R	-	1	2	RHBDF1	48512	1	0.714170	1.000000	0.803570	0.449000	0.322280	7.637000	0.833130	1.270000	0.442970	-0.229000	0.122940	CGG		TCGA-3A-A9IX-01A-11D-A40W-08	RHBDF1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000134178.2	1	0	1	29	556	0	120	1	9.643132e-01	13	93	0	120	2		0	0	0	0	0	2	1	1	29	549	0	116	2								-2.737383	1	1	121410	1	33	1	1	2	3	2.013518	0	0.100000	2	0.108470	0.990000	0.690000	1.000000	1.000000	0.946080	0.990000	1	0.850000	1.000000
SEPHS2	22928	broad.mit.edu	37	16	30456632	30456632	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	targeted			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr16:30456632G>T	ENST00000478753.2	-	1	870	c.417C>A	c.(415-417)ttC>ttA	p.F139L	SEPHS2_ENST00000500504.2_Missense_Mutation_p.F139L|SEPHS2_ENST00000542752.1_Missense_Mutation_p.F82L			Q99611	SPS2_HUMAN	selenophosphate synthetase 2			10					AGGGGTAAAAGAAGTCCGTGG	0.602000													Esophageal Squamous(81;1142 1261 11202 24614 35697)											0							SO:0001583	missense			ENST00000478753.2	1	1	hg19		.	.	.	.	.	.	.	.	.	.	G	19.460000	3.831271	0.712580	.	.	ENSG00000179918	ENST00000478753;ENST00000542752;ENST00000418751;ENST00000500504	T;T;T	0.28666	1.6;1.6;1.6	5.460000	3.490000	0.399570	PurM, N-terminal-like (1);AIR synthase-related protein (1);	0.000000	0.85682	D	0.000000	T	0.43366	0.1244	M	0.82056	2.57	0.807220	D	1.000000	P;P	0.40144	0.704;0.582	P;B	0.49085	0.6;0.331	T	0.42531	-0.9446	10	0.62326	D	0.03	-18.3451	6.836800	0.239410	0.2644:0.0:0.7356:0.0	.	139;82	Q99611;F5H8F9	SPS2_HUMAN;.	L	139;82;90;139	ENSP00000418669:F139L;ENSP00000443601:F82L;ENSP00000426234:F139L	ENSP00000390233:F90L	F	-	3	2	SEPHS2	30364133	1	0.714170	1.000000	0.803570	0.996000	0.888480	1.645000	0.372380	1.450000	0.477170	0.655000	0.942530	TTC		TCGA-3A-A9IX-01A-11D-A40W-08	SEPHS2-001	KNOWN	basic|seleno	protein_coding	protein_coding	OTTHUMT00000109640.11	0	0	0	10	222	0	63	1	9.510197e-01	19	99	0	63	2	1	9.998711e-01	22	372	0	302	2	1	9.969325e-01	10	220	0	62	2								-12.371280	1	1	0	0		1	1	2	3	2.013518	0	0.100000	2	0.108470	0.940000	0.470000	1.000000	1.000000	0.866430	0.940000	1	0.670000	1.000000
HERPUD1	9709	broad.mit.edu	37	16	56973198	56973198	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr16:56973198G>A	ENST00000439977.2	+	5	678	c.481G>A	c.(481-483)Ggt>Agt	p.G161S	RP11-325K4.2_ENST00000570210.1_RNA|HERPUD1_ENST00000570273.1_3'UTR|HERPUD1_ENST00000379792.2_Missense_Mutation_p.G136S|RP11-325K4.3_ENST00000565861.1_RNA|HERPUD1_ENST00000300302.5_Missense_Mutation_p.G160S|HERPUD1_ENST00000344114.4_Intron	NM_001010989.1|NM_014685.2	NP_001010989.1|NP_055500.1	Q15011	HERP1_HUMAN	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1			11					TGGTTTCTCCGGTTACACACC	0.493000			T	ERG	prostate										Dom	yes		16	16q12.2-q13	9709	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1		E	0							SO:0001583	missense			ENST00000439977.2	1	1	hg19	CCDS10771.1	.	.	.	.	.	.	.	.	.	.	G	15.120000	2.737940	0.490450	0.0	1.16E-4	ENSG00000051108	ENST00000439977;ENST00000379792;ENST00000300302	T	0.28666	1.6	5.970000	5.020000	0.671250	.	0.312317	0.37577	N	0.002021	T	0.35008	0.0917	L	0.44542	1.39	0.200740	N	0.999937	D;P;D;P	0.69078	0.997;0.745;0.997;0.751	P;B;P;B	0.54100	0.712;0.067;0.742;0.153	T	0.20773	-1.0265	10	0.08381	T	0.77	-6.0487	14.033900	0.646340	0.0719:0.0:0.9281:0.0	.	161;136;160;161	A4UAE9;E9PGD1;Q15011-2;Q15011	.;.;.;HERP1_HUMAN	S	160;136;161	ENSP00000369118:G136S	ENSP00000300302:G161S	G	+	1	0	HERPUD1	55530699	6.740000e-01	0.275490	0.967000	0.410340	0.965000	0.642790	2.328000	0.438670	1.527000	0.490860	0.585000	0.799380	GGT		TCGA-3A-A9IX-01A-11D-A40W-08	HERPUD1-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000257056.5	1	0	0	40	806	0	198	1	1	24	601	0	198	2		0	0	0	0	0	2	1	1	39	796	0	193	2								-2.872668	1	1	121412	3	40	1	1	2	3	2.013518	0	0.100000	2	0.108470	0.980000	0.700000	1.000000	1.000000	0.933878	0.980000	1	0.820000	1.000000
PHF12	57649	broad.mit.edu	37	17	27239855	27239855	+	Silent	SNP	C	C	T			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr17:27239855C>T	ENST00000332830.4	-	9	2544	c.1734G>A	c.(1732-1734)cgG>cgA	p.R578R	PHF12_ENST00000582655.1_5'UTR|PHF12_ENST00000577226.1_Silent_p.R578R|PHF12_ENST00000268756.3_Silent_p.R578R	NM_001033561.1	NP_001028733.1			PHD finger protein 12			30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)		GCCAGCCTTGCCGGTGTGAGA	0.637000																								0							SO:0001819	synonymous_variant			ENST00000332830.4	0	1	hg19	CCDS32598.1																																																																																				TCGA-3A-A9IX-01A-11D-A40W-08	PHF12-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000255941.1	0	0	0	6	361	0	82	0	3.982890e-01	0	74	0	82	2		0	0	0	0	0	2	1	9.565625e-01	6	335	0	75	2								-2.600466	1	1	0	0		1	1	2	3	2.025542	0	0.100000	2	0.111111	0.390000	0.150000	1.000000	0.320000	0.487731	0.390000	0	0.240000	1.000000
CYB561	1534	broad.mit.edu	37	17	61513435	61513435	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr17:61513435G>A	ENST00000392976.1	-	3	580	c.281C>T	c.(280-282)gCg>gTg	p.A94V	CYB561_ENST00000360793.3_Missense_Mutation_p.A94V|CYB561_ENST00000581573.1_Missense_Mutation_p.A94V|CYB561_ENST00000448884.2_Missense_Mutation_p.A94V|CYB561_ENST00000542042.1_Missense_Mutation_p.A161V|CYB561_ENST00000582297.1_Missense_Mutation_p.A94V|CYB561_ENST00000582034.1_Missense_Mutation_p.A65V|CYB561_ENST00000581163.1_5'UTR|CYB561_ENST00000582997.1_Missense_Mutation_p.A101V|CYB561_ENST00000584031.1_Missense_Mutation_p.A94V|CYB561_ENST00000392975.2_Missense_Mutation_p.A94V	NM_001017916.1	NP_001017916.1	P49447	CY561_HUMAN	cytochrome b561			4					GATGACGAGCGCAAAGATGTG	0.612000																								0							SO:0001583	missense			ENST00000392976.1	0	1	hg19	CCDS11636.1	.	.	.	.	.	.	.	.	.	.	G	10.730000	1.431165	0.257260	.	.	ENSG00000008283	ENST00000360793;ENST00000392976;ENST00000392975;ENST00000448884;ENST00000542042	T;T;T;T;T	0.54071	0.59;0.59;0.59;0.59;0.59	4.340000	4.340000	0.519310	Cytochrome b561, eukaryote (1);Cytochrome b561/ferric reductase transmembrane (2);	0.055735	0.64402	D	0.000001	T	0.71500	0.3347	M	0.78285	2.405	0.807220	D	1.000000	D;D;D;D	0.89917	0.997;1.0;0.998;0.984	P;D;P;P	0.91635	0.893;0.999;0.827;0.68	T	0.74702	-0.3576	10	0.54805	T	0.06	-16.3975	13.719400	0.627170	0.0:0.0:1.0:0.0	.	94;94;161;94	B7Z775;B3KTA1;F5H757;P49447	.;.;.;CY561_HUMAN	V	94;94;94;94;161	ENSP00000354028:A94V;ENSP00000376702:A94V;ENSP00000376701:A94V;ENSP00000400350:A94V;ENSP00000442773:A161V	ENSP00000354028:A94V	A	-	2	0	CYB561	58867167	1	0.714170	0.095000	0.209760	0.024000	0.109850	7.913000	0.874710	2.244000	0.739460	0.561000	0.740990	GCG		TCGA-3A-A9IX-01A-11D-A40W-08	CYB561-201	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000444843.1	0	0	0	5	301	0	53	0	5.117696e-01	0	93	0	53	2		0	0	0	0	0	2	1	9.353054e-01	5	296	0	53	2								-2.718022	1	1	121410	3	34	1	0	1	1	1.945631	0	0.100000	2	0.052632	0.320000	0.120000	0.640000	0.290000	0.348222	0.320000	0	0.200000	0.480000
SMAD4	4089	broad.mit.edu	37	18	48591918	48591918	+	Missense_Mutation	SNP	C	C	T	rs80338963		TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	targeted			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr18:48591918C>T	ENST00000342988.3	+	9	1619	c.1081C>T	c.(1081-1083)Cgc>Tgc	p.R361C	SMAD4_ENST00000588745.1_Missense_Mutation_p.R265C|SMAD4_ENST00000398417.2_Missense_Mutation_p.R361C	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	p.0?(36)|p.R361C(3)|p.R361S(2)|p.?(2)		454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)			TGGAGGAGATCGCTTTTGTTT	0.413000																								43	Whole gene deletion(36)|Substitution - Missense(5)|Unknown(2)	GRCh37	CM040450|CM041789|CM981228	SMAD4	M	rs80338963	SO:0001583	missense			ENST00000342988.3	1	1	hg19	CCDS11950.1	.	.	.	.	.	.	.	.	.	.	C	27.300000	4.820743	0.908730	.	.	ENSG00000141646	ENST00000342988;ENST00000544926;ENST00000398417	D;D	0.98164	-4.76;-4.76	5.860000	5.860000	0.939800	SMAD domain-like (1);SMAD/FHA domain (1);SMAD domain, Dwarfin-type (3);	0.000000	0.85682	D	0.000000	D	0.99275	0.9747	M	0.94021	3.485	0.807220	A	1.000000	D	0.89917	1.0	D	0.97110	1.0	D	0.99157	1.0860	9	0.87932	D	0	.	18.964600	0.926910	0.0:1.0:0.0:0.0	.	361	Q13485	SMAD4_HUMAN	C	361	ENSP00000341551:R361C;ENSP00000381452:R361C	ENSP00000341551:R361C	R	+	1	0	SMAD4	46845916	1	0.714170	1.000000	0.803570	0.998000	0.957120	4.718000	0.619300	2.771000	0.953190	0.563000	0.778840	CGC		TCGA-3A-A9IX-01A-11D-A40W-08	SMAD4-201	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000255993.3	0	0	0	10	289	0	90	0	7.954160e-01	1	87	0	90	2	1	9.999948e-01	11	789	0	689	2	1	9.968003e-01	10	285	0	86	2								-3.130658	1	1	0	0		1	0	1	1	1.992419	0	0.100000	2	0.092284	0.670000	0.340000	1.000000	1.000000	0.690535	0.670000	0	0.490000	0.900000
SLC7A9	11136	broad.mit.edu	37	19	33334838	33334838	+	Missense_Mutation	SNP	G	G	A	rs121908484		TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr19:33334838G>A	ENST00000023064.4	-	10	1188	c.997C>T	c.(997-999)Cgg>Tgg	p.R333W	SLC7A9_ENST00000587772.1_Missense_Mutation_p.R333W|SLC7A9_ENST00000590341.1_Missense_Mutation_p.R333W	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9			32	Esophageal squamous(110;0.137)			L-Cystine(DB00138)	TGACCCTCCCGGCCCGCCACG	0.567000													GBM(181;1335 2108 9644 44178 46689)											0		GRCh37	CM010449	SLC7A9	M	rs121908484	SO:0001583	missense			ENST00000023064.4	0	1	hg19	CCDS12425.1	.	.	.	.	.	.	.	.	.	.	G	17.820000	3.484195	0.639620	2.27E-4	1.16E-4	ENSG00000021488	ENST00000023064	D	0.91792	-2.91	5.370000	3.170000	0.364340	Amino acid permease domain (1);	0.000000	0.85682	D	0.000000	D	0.96806	0.8957	M	0.93808	3.46	0.807220	A	1.000000	D;D	0.89917	1.0;1.0	D;D	0.91635	0.999;0.999	D	0.98100	1.0414	9	0.87932	D	0	.	13.985400	0.643310	0.0:0.0:0.7234:0.2766	.	333;333	Q53FY4;P82251	.;BAT1_HUMAN	W	333	ENSP00000023064:R333W	ENSP00000023064:R333W	R	-	1	2	SLC7A9	38026678	1	0.714170	0.997000	0.539660	0.663000	0.391080	3.879000	0.561380	0.597000	0.298110	-0.182000	0.129630	CGG		TCGA-3A-A9IX-01A-11D-A40W-08	SLC7A9-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000450585.1	0	0	0	5	203	0	49		0	0	0	0	49	2		0	0	0	0	0	2	1	9.307665e-01	5	194	0	48	2								-6.435171	1	1	121412	11	40	1	1	2	3	2.007608	0	0.100000	2	0.107143	0.560000	0.200000	1.000000	1.000000	0.604751	0.560000	0	0.340000	0.990000
ALDH16A1	126133	broad.mit.edu	37	19	49964157	49964157	+	Splice_Site	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr19:49964157G>A	ENST00000293350.4	+	5	740		c.e5+1		CTD-3148I10.9_ENST00000599536.1_5'Flank|ALDH16A1_ENST00000540132.1_Splice_Site|ALDH16A1_ENST00000455361.2_Splice_Site|ALDH16A1_ENST00000433981.2_Splice_Site	NM_153329.3	NP_699160.2	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1			20		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)			CTGGCTGTGGGTAAATGATGG	0.557000																								0							SO:0001630	splice_region_variant			ENST00000293350.4	1	1	hg19	CCDS12766.1	.	.	.	.	.	.	.	.	.	.	G	20.300000	3.966777	0.741310	.	.	ENSG00000161618	ENST00000293350;ENST00000455361;ENST00000540132;ENST00000433981	.	.	.	5.380000	5.380000	0.774910	.	.	.	.	.	.	.	.	.	.	.	0.807220	D	1.000000	.	.	.	.	.	.	.	.	.	.	.	.	.	.	15.027600	0.716820	0.0:0.0:1.0:0.0	.	.	.	.	.	-1	.	.	.	+	.	.	ALDH16A1	54655969	1	0.714170	0.999000	0.593770	0.988000	0.763860	3.134000	0.505380	2.704000	0.923520	0.585000	0.799380	.		TCGA-3A-A9IX-01A-11D-A40W-08	ALDH16A1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000465358.1	0	0	0	10	309	1	94	1	1.177558e-02	3	2	1	94	2		0	0	0	0	0	2	0	3.247227e-01	10	306	1	92	13								-3.578888	1	1	0	0		1	1	2	3	2.021362	0	0.100000	2	0.110232	0.700000	0.340000	1.000000	1.000000	0.724217	0.700000	0	0.490000	1.000000
POLD1	5424	broad.mit.edu	37	19	50909518	50909518	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr19:50909518C>T	ENST00000440232.2	+	11	1375	c.1322C>T	c.(1321-1323)aCg>aTg	p.T441M	POLD1_ENST00000599857.1_Missense_Mutation_p.T441M|POLD1_ENST00000595904.1_Missense_Mutation_p.T441M	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit			39		all_neural(266;0.0571)			TCCAAGCAGACGGGCCGGCGG	0.622000								DNA polymerases (catalytic subunits)																0							SO:0001583	missense			ENST00000440232.2	0	1	hg19	CCDS12795.1	.	.	.	.	.	.	.	.	.	.	C	2.450000	-0.326515	0.053500	0.0	2.33E-4	ENSG00000062822	ENST00000440232;ENST00000376930	T	0.16073	2.37	4.540000	-2.900000	0.056480	DNA-directed DNA polymerase, family B, exonuclease domain (1);Ribonuclease H-like (1);	0.206121	0.46758	N	0.000280	T	0.01835	0.0058	N	0.00061	-2.33	0.230100	N	0.998434	B;B	0.06786	0.001;0.0	B;B	0.04013	0.001;0.001	T	0.43196	-0.9406	10	0.02654	T	1	-18.2908	6.708300	0.232620	0.1254:0.5005:0.0:0.3741	.	441;441	E7EVW0;P28340	.;DPOD1_HUMAN	M	441;442	ENSP00000406046:T441M	ENSP00000366129:T442M	T	+	2	0	POLD1	55601330	9.970000e-01	0.396340	0.675000	0.299170	0.992000	0.810270	1.237000	0.326950	-0.404000	0.076100	-0.302000	0.093040	ACG		TCGA-3A-A9IX-01A-11D-A40W-08	POLD1-002	KNOWN	alternative_5_UTR|NAGNAG_splice_site|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000464732.1	0	0	0	6	390	0	84	1	1.429178e-01	2	35	0	84	2		0	0	0	0	0	2	1	9.620938e-01	6	379	0	82	2								-2.764564	1	1	121410	10	44	1	1	2	3	2.021362	0	0.100000	2	0.110232	0.360000	0.140000	1.000000	0.300000	0.458568	0.360000	0	0.220000	1.000000
SLC27A3	11000	broad.mit.edu	37	1	153747855	153747855	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr1:153747855G>A	ENST00000368661.3	+	1	88	c.23G>A	c.(22-24)cGc>cAc	p.R8H	SLC27A3_ENST00000271857.2_Missense_Mutation_p.R89H|SLC27A3_ENST00000484014.1_3'UTR	NM_024330.1	NP_077306.1	Q5K4L6	S27A3_HUMAN	solute carrier family 27 (fatty acid transporter), member 3			14	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		CAGCGCACGCGCGCTCCCTGG	0.677000																								0							SO:0001583	missense			ENST00000368661.3	1	1	hg19	CCDS1053.1	.	.	.	.	.	.	.	.	.	.	G	18.070000	3.541870	0.651980	.	.	ENSG00000143554	ENST00000271857;ENST00000368661	T;T	0.62105	0.05;0.2	4.320000	4.320000	0.515710	.	.	.	.	.	T	0.42810	0.1219	N	0.08118	0	0.281440	N	0.929672	D	0.76494	0.999	P	0.56751	0.805	T	0.46965	-0.9153	9	0.87932	D	0	-3.5406	12.325600	0.550090	0.0:0.0:1.0:0.0	.	8	Q5K4L6	S27A3_HUMAN	H	89;8	ENSP00000271857:R89H;ENSP00000357650:R8H	ENSP00000271857:R89H	R	+	2	0	SLC27A3	152014479	1	0.714170	1.000000	0.803570	0.493000	0.335540	1.460000	0.352440	1.973000	0.574460	0.462000	0.415740	CGC		TCGA-3A-A9IX-01A-11D-A40W-08	SLC27A3-201	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding		1	0	0	20	331	0	76	0	2.246043e-01	1	14	0	76	2		0	0	0	0	0	2	1	9.999946e-01	20	323	0	76	2								-19.996570	1	1	0	0		1	1	2	3	2.003783	0	0.100000	2	0.106256	0.990000	0.730000	1.000000	1.000000	0.971580	0.990000	1	0.930000	1.000000
ZNF496	84838	broad.mit.edu	37	1	247473673	247473673	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr1:247473673T>C	ENST00000294753.4	-	6	1201	c.737A>G	c.(736-738)tAt>tGt	p.Y246C	ZNF496_ENST00000462139.1_5'UTR|ZNF496_ENST00000366498.2_Missense_Mutation_p.Y282C	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496			36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)		GAACTCTCCATAGAAGCCAGT	0.507000																								0							SO:0001583	missense			ENST00000294753.4	1	1	hg19	CCDS1631.1	.	.	.	.	.	.	.	.	.	.	T	16.370000	3.103212	0.561830	.	.	ENSG00000162714	ENST00000294753;ENST00000366498	T;T	0.07021	3.23;3.23	3.650000	3.650000	0.418500	Krueppel-associated box (4);	0.000000	0.38897	N	0.001537	T	0.27559	0.0677	M	0.84156	2.68	0.358510	D	0.826793	D;D	0.89917	1.0;1.0	D;D	0.91635	0.999;0.995	T	0.30090	-0.9990	10	0.56958	D	0.05	-23.0442	8.891300	0.354340	0.0:0.0:0.0:1.0	.	282;246	Q96IT1-2;Q96IT1	.;ZN496_HUMAN	C	246;282	ENSP00000294753:Y246C;ENSP00000355454:Y282C	ENSP00000294753:Y246C	Y	-	2	0	ZNF496	245540296	9.870000e-01	0.356910	0.963000	0.404240	0.966000	0.646010	3.047000	0.498540	1.672000	0.508840	0.533000	0.621200	TAT		TCGA-3A-A9IX-01A-11D-A40W-08	ZNF496-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000098655.2	1	0	0	14	282	0	83	0	4.092516e-01	1	27	0	83	2		0	0	0	0	0	2	1	9.997732e-01	14	282	0	81	2								-15.967410	1	1	0	0		1	1	2	3	2.013004	0	0.100000	2	0.108470	0.990000	0.560000	1.000000	1.000000	0.910698	0.990000	1	0.760000	1.000000
MAVS	57506	broad.mit.edu	37	20	3844972	3844972	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr20:3844972G>A	ENST00000428216.2	+	6	823	c.695G>A	c.(694-696)cGt>cAt	p.R232H	MAVS_ENST00000358134.6_3'UTR|MAVS_ENST00000416600.2_Missense_Mutation_p.R91H	NM_020746.4	NP_065797.2	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein			14					CCCCTGGCCCGTTCCACCCCC	0.622000																								0							SO:0001583	missense			ENST00000428216.2	0	1	hg19	CCDS33437.1	.	.	.	.	.	.	.	.	.	.	G	23.600000	4.437866	0.838850	0.0	1.16E-4	ENSG00000088888	ENST00000416600;ENST00000428216	T;T	0.55760	0.5;1.96	4.720000	4.720000	0.597630	.	0.780557	0.11868	N	0.521739	T	0.63450	0.2512	L	0.46157	1.445	0.308850	N	0.731009	D	0.76494	0.999	P	0.61003	0.882	T	0.62243	-0.6895	10	0.59425	D	0.04	-5.5757	13.426200	0.610260	0.0:0.0:1.0:0.0	.	232	Q7Z434	MAVS_HUMAN	H	91;232	ENSP00000413749:R91H;ENSP00000401980:R232H	ENSP00000413749:R91H	R	+	2	0	MAVS	3792972	9.010000e-01	0.306850	0.753000	0.312250	0.997000	0.918780	4.000000	0.570390	2.634000	0.892830	0.650000	0.862430	CGT		TCGA-3A-A9IX-01A-11D-A40W-08	MAVS-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000077784.3	0	0	0	6	423	0	98	0	3.702087e-02	0	18	0	98	2		0	0	0	0	0	2	1	9.614733e-01	6	409	0	93	2								-2.467075	0	1	121410	13	43	1	1	2	3	2.000526	0	0.100000	2	0.105812	0.310000	0.120000	1.000000	0.280000	0.391332	0.310000	0	0.200000	0.520000
TMPRSS15	5651	broad.mit.edu	37	21	19653400	19653400	+	Silent	SNP	G	G	A	rs148756781		TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr21:19653400G>A	ENST00000284885.3	-	22	2658	c.2625C>T	c.(2623-2625)aaC>aaT	p.N875N		NM_002772.2	NP_002763	P98073	ENTK_HUMAN	transmembrane protease, serine 15			85					TGGCAATGTCGTTGTCCTTTC	0.348000																								0							SO:0001819	synonymous_variant			ENST00000284885.3	0	1	hg19	CCDS13571.1																																																																																				TCGA-3A-A9IX-01A-11D-A40W-08	TMPRSS15-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000158231.2	0	0	0	7	607	1	177		0	0	0	1	177	2		0	0	0	0	0	2	0	1.211669e-01	6	597	1	176	13								-2.506517	1	1	0	0		1	0	0	0	1.951454	0	0.100000	2	0.071207	0.230000	0.100000	0.420000	0.210000	0.246350	0.230000	0	0.150000	0.330000
KCNJ6	3763	broad.mit.edu	37	21	39087258	39087258	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr21:39087258C>T	ENST00000609713.1	-	3	791	c.202G>A	c.(202-204)Ggc>Agc	p.G68S	KCNJ6-IT1_ENST00000435001.1_RNA|KCNJ6_ENST00000288309.6_Missense_Mutation_p.G68S	NM_002240.3	NP_002231.1	P48051	KCNJ6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6			22				Halothane(DB01159)	CTCACGTTGCCGTGATGAACA	0.488000													Pancreas(48;379 1118 2936 19024 28214)											0							SO:0001583	missense			ENST00000609713.1	1	1	hg19	CCDS42927.1	.	.	.	.	.	.	.	.	.	.	C	20.200000	3.941544	0.735570	.	.	ENSG00000157542	ENST00000400482;ENST00000288309	D;D	0.93659	-3.26;-3.26	5.950000	5.950000	0.964410	Potassium channel, inwardly rectifying, Kir, conserved region 2 (1);	0.000000	0.85682	D	0.000000	D	0.96463	0.8846	M	0.69523	2.12	0.807220	D	1.000000	D	0.89917	1.0	D	0.97110	1.0	D	0.94767	0.7941	10	0.33141	T	0.24	.	20.393200	0.989650	0.0:1.0:0.0:0.0	.	68	P48051	IRK6_HUMAN	S	68	ENSP00000383330:G68S;ENSP00000288309:G68S	ENSP00000288309:G68S	G	-	1	0	KCNJ6	38009128	1	0.714170	0.994000	0.499520	0.624000	0.377220	7.818000	0.864160	2.824000	0.972090	0.655000	0.942530	GGC		TCGA-3A-A9IX-01A-11D-A40W-08	KCNJ6-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000194828.2	0	0	0	23	563	0	110		0	0	0	0	110	2		0	0	0	0	0	2	1	9.999992e-01	23	554	0	104	2								-2.676352	1	1	0	0		1	0	0	0	1.951454	0	0.100000	2	0.071207	0.750000	0.490000	1.000000	1.000000	0.766745	0.750000	0	0.610000	0.920000
GREB1	9687	broad.mit.edu	37	2	11772081	11772081	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr2:11772081G>A	ENST00000381486.2	+	27	4958	c.4658G>A	c.(4657-4659)cGt>cAt	p.R1553H	GREB1_ENST00000234142.5_Missense_Mutation_p.R1553H|GREB1_ENST00000396123.1_Missense_Mutation_p.R551H	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1			30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)				ACCACCGGCCGTCACGAACAT	0.443000													Ovarian(39;850 945 2785 23371 33093)											0							SO:0001583	missense			ENST00000381486.2	1	1	hg19	CCDS42655.1	.	.	.	.	.	.	.	.	.	.	G	24.600000	4.554458	0.862310	.	.	ENSG00000196208	ENST00000381486;ENST00000234142;ENST00000396123	T;T;T	0.55930	0.49;0.49;0.49	5.480000	5.480000	0.808510	.	0.000000	0.85682	D	0.000000	T	0.74230	0.3689	M	0.75615	2.305	0.807220	D	1.000000	D	0.89917	1.0	D	0.91635	0.999	T	0.76591	-0.2903	10	0.72032	D	0.01	-21.4125	19.335800	0.943190	0.0:0.0:1.0:0.0	.	1553	Q4ZG55	GREB1_HUMAN	H	1553;1553;551	ENSP00000370896:R1553H;ENSP00000234142:R1553H;ENSP00000379429:R551H	ENSP00000234142:R1553H	R	+	2	0	GREB1	11689532	1	0.714170	0.963000	0.404240	0.471000	0.328880	9.343000	0.970470	2.573000	0.868260	0.557000	0.710580	CGT		TCGA-3A-A9IX-01A-11D-A40W-08	GREB1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000280490.1	1	0	0	13	287	0	92	0	2.294931e-03	0	2	0	92	2		0	0	0	0	0	2	1	9.995122e-01	12	283	0	90	2								-4.061748	1	1	0	0		1	1	2	3	2.007829	0	0.100000	2	0.107143	0.920000	0.500000	1.000000	1.000000	0.869836	0.920000	1	0.680000	1.000000
FIGN	55137	broad.mit.edu	37	2	164466403	164466403	+	Nonsense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr2:164466403G>A	ENST00000333129.3	-	3	2253	c.1939C>T	c.(1939-1941)Cga>Tga	p.R647*	FIGN_ENST00000482917.1_5'Flank|FIGN_ENST00000409634.1_Intron	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin			47					ATTAAAAGTCGTTTCATGAAG	0.443000																								0							SO:0001587	stop_gained			ENST00000333129.3	0	1	hg19	CCDS2221.2	.	.	.	.	.	.	.	.	.	.	G	39.000000	7.338110	0.982210	.	.	ENSG00000182263	ENST00000333129	.	.	.	5.770000	4.870000	0.633300	.	0.000000	0.85682	D	0.000000	.	.	.	.	.	.	0.807220	D	1.000000	.	.	.	.	.	.	.	.	.	.	0.02654	T	1	-24.9622	13.551800	0.617360	0.0:0.0:0.708:0.292	.	.	.	.	X	647	.	ENSP00000333836:R647X	R	-	1	2	FIGN	164174649	1	0.714170	1.000000	0.803570	0.997000	0.918780	3.912000	0.563860	1.382000	0.463850	0.467000	0.429560	CGA		TCGA-3A-A9IX-01A-11D-A40W-08	FIGN-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000157220.2	0	0	0	22	356	1	53	0	8.211089e-02	0	8	1	53	2		0	0	0	0	0	2	0	4.852906e-01	22	353	1	49	23								-19.999970	1	1	0	0		1	1	2	3	2.007829	0	0.100000	2	0.107143	0.990000	0.770000	1.000000	1.000000	0.978355	0.990000	1	0.970000	1.000000
CASP10	843	broad.mit.edu	37	2	202073970	202073970	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr2:202073970C>T	ENST00000272879.5	+	9	1284	c.1100C>T	c.(1099-1101)tCg>tTg	p.S367L	CASP10_ENST00000346817.5_Missense_Mutation_p.S324L|CASP10_ENST00000492363.1_3'UTR|CASP10_ENST00000313728.7_Missense_Mutation_p.S300L|CASP10_ENST00000360132.3_3'UTR|CASP10_ENST00000448480.1_Missense_Mutation_p.S324L|CASP10_ENST00000286186.6_Missense_Mutation_p.S367L	NM_032974.4	NP_116756.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase			27					GTCTACTCTTCGGATGAGGCC	0.527000																								0							SO:0001583	missense			ENST00000272879.5	0	1	hg19	CCDS2338.1	.	.	.	.	.	.	.	.	.	.	C	17.090000	3.299455	0.601950	.	.	ENSG00000003400	ENST00000286186;ENST00000272879;ENST00000346817;ENST00000313728;ENST00000448480	T;T;T;T;T	0.20332	2.08;2.08;2.08;2.08;2.08	5.050000	5.050000	0.679360	Peptidase C14, caspase catalytic (1);Peptidase C14, caspase precursor p45, core (1);Peptidase C14, ICE, catalytic subunit p20 (1);	0.342415	0.29087	N	0.013181	T	0.49440	0.1557	M	0.89353	3.025	0.313270	N	0.685250	D;D;D;D;D	0.89917	0.978;1.0;1.0;0.994;0.995	P;D;D;P;P	0.72982	0.759;0.947;0.979;0.772;0.768	T	0.61242	-0.7102	10	0.52906	T	0.07	.	10.695000	0.458940	0.1465:0.7121:0.1414:0.0	.	300;324;367;324;367	Q92851-6;Q92851-5;Q92851;Q92851-2;Q92851-4	.;.;CASPA_HUMAN;.;.	L	367;367;324;300;324	ENSP00000286186:S367L;ENSP00000272879:S367L;ENSP00000237865:S324L;ENSP00000314599:S300L;ENSP00000396835:S324L	ENSP00000272879:S367L	S	+	2	0	CASP10	201782215	0	0.058580	0.017000	0.161240	0.020000	0.101350	0.844000	0.276540	2.361000	0.800490	0.650000	0.862430	TCG		TCGA-3A-A9IX-01A-11D-A40W-08	CASP10-002	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000256273.1	0	0	0	8	484	0	82	1	1.013487e-01	2	27	0	82	2		0	0	0	0	0	2	1	9.887528e-01	8	477	0	79	2								-2.756312	1	1	121412	1	32	1	1	2	3	2.019140	0	0.100000	2	0.109792	0.370000	0.160000	1.000000	0.330000	0.466462	0.370000	0	0.250000	1.000000
PID1	55022	broad.mit.edu	37	2	229890686	229890686	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr2:229890686G>A	ENST00000354069.6	-	3	445	c.415C>T	c.(415-417)Cgg>Tgg	p.R139W	PID1_ENST00000482518.2_Intron|PID1_ENST00000392054.3_Missense_Mutation_p.R137W|PID1_ENST00000409462.1_Missense_Mutation_p.R57W|PID1_ENST00000392055.3_Missense_Mutation_p.R106W			Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1			26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)			TGGAATGGCCGGATTTCCAGG	0.567000																								0							SO:0001583	missense			ENST00000354069.6	1	1	hg19		.	.	.	.	.	.	.	.	.	.	G	20.600000	4.010246	0.750460	.	.	ENSG00000153823	ENST00000392054;ENST00000409462;ENST00000392055;ENST00000542363;ENST00000354069	.	.	.	5.550000	5.550000	0.834470	Pleckstrin homology-type (1);	0.124895	0.56097	D	0.000030	T	0.68622	0.3021	L	0.36672	1.1	0.584320	D	0.999999	D;D;D;D	0.89917	1.0;1.0;1.0;1.0	D;D;D;D	0.91635	0.968;0.968;0.999;0.998	T	0.64508	-0.6391	8	.	.	.	-10.0864	18.864200	0.922850	0.0:0.0:1.0:0.0	.	57;106;137;139	Q7Z2X4-3;Q7Z2X4-4;Q7Z2X4-2;Q7Z2X4	.;.;.;PCLI1_HUMAN	W	137;57;106;139;139	.	.	R	-	1	2	PID1	229598930	1	0.714170	0.994000	0.499520	0.952000	0.607820	7.240000	0.781920	2.768000	0.951710	0.655000	0.942530	CGG		TCGA-3A-A9IX-01A-11D-A40W-08	PID1-005	KNOWN	basic	protein_coding	protein_coding	OTTHUMT00000331810.2	1	0	0	14	252	0	45	0	8.276573e-01	1	59	0	45	2		0	0	0	0	0	2	1	9.997579e-01	13	250	0	45	2								-3.076744	1	1	121410	2	33	1	1	2	3	2.019140	0	0.100000	2	0.109792	0.990000	0.630000	1.000000	1.000000	0.946587	0.990000	1	0.850000	1.000000
CNTN6	27255	broad.mit.edu	37	3	1418745	1418745	+	Missense_Mutation	SNP	G	G	A	rs140014929		TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr3:1418745G>A	ENST00000446702.2	+	17	2779	c.2152G>A	c.(2152-2154)Gtc>Atc	p.V718I	CNTN6_ENST00000350110.2_Missense_Mutation_p.V718I|CNTN6_ENST00000539053.1_Missense_Mutation_p.V646I			Q9UQ52	CNTN6_HUMAN	contactin 6	p.V718I(2)		90		all_cancers(2;0.000164)|all_epithelial(2;0.107)			GTCTGAACTCGTCATTACGTG	0.373000																								2	Substitution - Missense(2)						SO:0001583	missense			ENST00000446702.2	1	1	hg19	CCDS2557.1	.	.	.	.	.	.	.	.	.	.	G	13.960000	2.392335	0.424100	2.27E-4	1.16E-4	ENSG00000134115	ENST00000446702;ENST00000539053;ENST00000350110	T;T;T	0.53857	0.6;0.6;0.6	5.760000	-0.130000	0.134980	Fibronectin, type III (3);Immunoglobulin-like fold (1);	0.235772	0.29684	N	0.011465	T	0.40372	0.1114	L	0.43152	1.355	0.443950	D	0.997306	B	0.15930	0.015	B	0.10450	0.005	T	0.20405	-1.0276	10	0.32370	T	0.25	.	11.084600	0.480800	0.3437:0.0:0.6563:0.0	.	718	Q9UQ52	CNTN6_HUMAN	I	718;646;718	ENSP00000407822:V718I;ENSP00000442791:V646I;ENSP00000341882:V718I	ENSP00000341882:V718I	V	+	1	0	CNTN6	1393745	1	0.714170	0.989000	0.466690	0.998000	0.957120	3.636000	0.543170	0.098000	0.175220	0.655000	0.942530	GTC		TCGA-3A-A9IX-01A-11D-A40W-08	CNTN6-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000239235.2	0	0	0	14	409	0	55		0	0	0	0	55	2		0	0	0	0	0	2	1	9.997472e-01	14	405	0	54	2								-13.100220	1	1	121412	8	43	1	1	2	3	2.017085	0	0.100000	2	0.109352	0.720000	0.390000	1.000000	1.000000	0.742233	0.720000	0	0.530000	1.000000
SI	6476	broad.mit.edu	37	3	164786914	164786914	+	Missense_Mutation	SNP	C	C	T	rs149498200		TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr3:164786914C>T	ENST00000264382.3	-	4	387	c.325G>A	c.(325-327)Gtt>Att	p.V109I		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)			218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)		Acarbose(DB00284)|Scopolamine(DB00747)	TGATTATCAACGAAGAAGCAC	0.363000										HNSCC(35;0.089)														0							SO:0001583	missense			ENST00000264382.3	1	1	hg19	CCDS3196.1	.	.	.	.	.	.	.	.	.	.	C	13.140000	2.146805	0.379230	4.54E-4	0.0	ENSG00000090402	ENST00000264382	D	0.85171	-1.95	5.910000	5.910000	0.952730	Glycoside hydrolase-type carbohydrate-binding (1);P-type trefoil (3);	0.720617	0.14150	N	0.338066	T	0.82116	0.4967	L	0.57536	1.79	0.093100	N	1.000000	P	0.35363	0.497	B	0.30029	0.11	T	0.77469	-0.2576	10	0.66056	D	0.02	.	13.020100	0.587810	0.2008:0.7992:0.0:0.0	.	109	P14410	SUIS_HUMAN	I	109	ENSP00000264382:V109I	ENSP00000264382:V109I	V	-	1	0	SI	166269608	5.000000e-03	0.159910	0.209000	0.236190	0.343000	0.289850	1.081000	0.307910	2.802000	0.963970	0.655000	0.942530	GTT		TCGA-3A-A9IX-01A-11D-A40W-08	SI-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000350116.1	1	0	0	20	199	0	46		0	0	0	0	46	2		0	0	0	0	0	2	1	9.999956e-01	20	195	0	45	2								-8.339670	1	1	121392	7	41	1	1	2	3	2.011289	0	0.100000	2	0.108028	0.990000	0.990000	1.000000	1.000000	0.999612	0.990000	1	0.990000	1.000000
MST1R	4486	broad.mit.edu	37	3	49932714	49932714	+	Missense_Mutation	SNP	G	G	A	rs144584611		TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr3:49932714G>A	ENST00000296474.3	-	14	3184	c.3157C>T	c.(3157-3159)Cgg>Tgg	p.R1053W	MST1R_ENST00000344206.4_Missense_Mutation_p.R1004W	NM_002447.2	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)			37					GACTCTTTCCGCAGCAGTGGC	0.567000																								0							SO:0001583	missense			ENST00000296474.3	0	1	hg19	CCDS2807.1	.	.	.	.	.	.	.	.	.	.	g	13.760000	2.332890	0.412970	.	.	ENSG00000164078	ENST00000296474;ENST00000344206	T;T	0.10288	2.89;2.89	5.840000	1.710000	0.243560	.	0.615148	0.17959	N	0.156241	T	0.18173	0.0436	M	0.61703	1.905	0.093100	N	1.000000	D	0.71674	0.998	P	0.53185	0.72	T	0.04065	-1.0980	10	0.62326	D	0.03	-2.2724	8.085200	0.307690	0.1508:0.0:0.6705:0.1787	.	1053	Q04912	RON_HUMAN	W	1053;1004	ENSP00000296474:R1053W;ENSP00000341325:R1004W	ENSP00000296474:R1053W	R	-	1	2	MST1R	49907718	0	0.058580	0.363000	0.258750	0.029000	0.119000	0.091000	0.150460	0.826000	0.346610	-0.215000	0.126440	CGG		TCGA-3A-A9IX-01A-11D-A40W-08	MST1R-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000345403.1	0	0	0	8	716	0	166	0	9.558859e-02	0	41	0	166	2		0	0	0	0	0	2	1	9.887909e-01	8	707	0	161	2								-2.415515	0	1	121410	14	47	1	1	2	3	2.017085	0	0.100000	2	0.109352	0.250000	0.110000	1.000000	0.220000	0.366250	0.250000	0	0.160000	0.530000
WDR82	80335	broad.mit.edu	37	3	52292632	52292632	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr3:52292632C>A	ENST00000296490.3	-	8	1113	c.832G>T	c.(832-834)Gat>Tat	p.D278Y		NM_025222.3	NP_079498.2	Q6UXN9	WDR82_HUMAN	WD repeat domain 82								TGTTTACCATCCAACACAGCT	0.448000																								0							SO:0001583	missense			ENST00000296490.3	1	1	hg19	CCDS2851.2	.	.	.	.	.	.	.	.	.	.	C	21.400000	4.143216	0.778880	.	.	ENSG00000164091	ENST00000296490	T	0.18502	2.21	5.870000	5.870000	0.943060	WD40/YVTN repeat-like-containing domain (1);WD40 repeat-like-containing domain (1);WD40-repeat-containing domain (1);	0.000000	0.85682	D	0.000000	T	0.30103	0.0754	L	0.31065	0.9	0.807220	D	1.000000	P	0.45531	0.86	P	0.57009	0.811	T	0.00708	-1.1600	10	0.66056	D	0.02	-12.5223	20.195700	0.982420	0.0:1.0:0.0:0.0	.	278	Q6UXN9	WDR82_HUMAN	Y	278	ENSP00000296490:D278Y	ENSP00000296490:D278Y	D	-	1	0	WDR82	52267672	1	0.714170	1.000000	0.803570	0.995000	0.863560	7.581000	0.825350	2.780000	0.956700	0.563000	0.778840	GAT		TCGA-3A-A9IX-01A-11D-A40W-08	WDR82-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000317919.1	1	0	0	31	490	0	87	1	9.974851e-01	7	139	0	87	2		0	0	0	0	0	2	1	1	31	482	0	85	2								-6.673204	1	1	0	0		1	1	2	3	2.017085	0	0.100000	2	0.109352	0.990000	0.840000	1.000000	1.000000	0.988995	0.990000	1	0.990000	1.000000
ROBO2	6092	broad.mit.edu	37	3	77600066	77600066	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr3:77600066C>T	ENST00000461745.1	+	8	2057	c.1157C>T	c.(1156-1158)gCg>gTg	p.A386V	ROBO2_ENST00000487694.3_Missense_Mutation_p.A402V|ROBO2_ENST00000332191.8_Missense_Mutation_p.A386V	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)			117					CGTTCCGACGCGGGTTACTAC	0.473000																								0							SO:0001583	missense			ENST00000461745.1	0	1	hg19	CCDS43109.1	.	.	.	.	.	.	.	.	.	.	C	14.000000	2.406025	0.427150	.	.	ENSG00000185008	ENST00000487694;ENST00000403211;ENST00000343019;ENST00000461745;ENST00000332191;ENST00000398467	T;T;T	0.68479	-0.33;-0.33;-0.33	5.490000	4.550000	0.560140	Immunoglobulin I-set (1);Immunoglobulin subtype 2 (1);Immunoglobulin-like (1);Immunoglobulin-like fold (1);	0.000000	0.45606	D	0.000351	T	0.75072	0.3800	L	0.50919	1.6	0.397180	D	0.971425	D;D;D	0.69078	0.995;0.997;0.995	D;D;D	0.67231	0.938;0.942;0.95	T	0.72398	-0.4306	9	0.26408	T	0.33	.	16.073300	0.809510	0.0:0.866:0.134:0.0	.	402;386;386	Q19AB5;F8W703;Q9HCK4	.;.;ROBO2_HUMAN	V	402;402;406;386;386;107	ENSP00000417335:A402V;ENSP00000417164:A386V;ENSP00000327536:A386V	ENSP00000327536:A386V	A	+	2	0	ROBO2	77682756	1	0.714170	0.225000	0.238940	0.113000	0.197640	6.001000	0.706850	2.742000	0.940160	0.591000	0.815410	GCG		TCGA-3A-A9IX-01A-11D-A40W-08	ROBO2-002	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000352600.2	1	0	0	15	284	0	26	0	2.992233e-03	0	2	0	26	2		0	0	0	0	0	2	1	9.998439e-01	14	274	0	24	2								-3.221883	1	1	120850	17	44	1	1	2	3	2.023999	0	0.100000	2	0.121951	0.990000	0.630000	1.000000	1.000000	0.945664	0.990000	1	0.840000	1.000000
FAM71B	153745	broad.mit.edu	37	5	156592698	156592698	+	Missense_Mutation	SNP	C	C	A	rs146865558		TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr5:156592698C>A	ENST00000302938.4	-	1	577	c.482G>T	c.(481-483)cGg>cTg	p.R161L		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	p.R161L(1)		68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)		GAGATCTTCCCGTGTGTCAGA	0.498000																								1	Substitution - Missense(1)						SO:0001583	missense			ENST00000302938.4	1	1	hg19	CCDS4335.1	.	.	.	.	.	.	.	.	.	.	C	15.630000	2.888978	0.520140	.	.	ENSG00000170613	ENST00000302938	T	0.17054	2.3	4.560000	4.560000	0.562230	.	0.345278	0.24813	N	0.035395	T	0.36853	0.0982	M	0.62154	1.92	0.093100	N	1.000000	D	0.65815	0.995	D	0.69479	0.964	T	0.06807	-1.0806	10	0.54805	T	0.06	-3.8761	13.561900	0.617950	0.0:1.0:0.0:0.0	.	161	Q8TC56	FA71B_HUMAN	L	161	ENSP00000305596:R161L	ENSP00000305596:R161L	R	-	2	0	FAM71B	156525276	2.700000e-02	0.192310	0.010000	0.147220	0.624000	0.377220	1.032000	0.301780	2.469000	0.834160	0.655000	0.942530	CGG		TCGA-3A-A9IX-01A-11D-A40W-08	FAM71B-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000252570.2	0	0	0	15	592	0	127		0	0	0	0	127	2		0	0	0	0	0	2	1	9.998501e-01	15	580	0	125	2								-1.667355	0	1	0	0		1	1	2	3	2.004622	0	0.100000	2	0.106700	0.520000	0.290000	1.000000	0.500000	0.578811	0.520000	0	0.390000	0.760000
RELN	5649	broad.mit.edu	37	7	103474008	103474008	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr7:103474008G>A	ENST00000428762.1	-	3	608	c.449C>T	c.(448-450)gCg>gTg	p.A150V	RELN_ENST00000343529.5_Missense_Mutation_p.A150V|RELN_ENST00000424685.2_Missense_Mutation_p.A150V	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin			227					GCCTGTGCCCGCAGGTGGAGC	0.473000													NSCLC(146;835 1944 15585 22231 52158)											0							SO:0001583	missense			ENST00000428762.1	1	1	hg19	CCDS47680.1	.	.	.	.	.	.	.	.	.	.	G	21.600000	4.172734	0.784520	.	.	ENSG00000189056	ENST00000428762;ENST00000343529;ENST00000424685;ENST00000448171	T;T;T	0.28454	1.61;1.61;1.61	5.330000	5.330000	0.759180	Reeler domain (2);	0.060775	0.64402	D	0.000002	T	0.31513	0.0799	N	0.14661	0.345	0.547530	D	0.999989	D;D	0.56035	0.968;0.974	P;P	0.50708	0.516;0.648	T	0.19549	-1.0302	10	0.72032	D	0.01	.	19.393100	0.945920	0.0:0.0:1.0:0.0	.	150;150	P78509-2;P78509	.;RELN_HUMAN	V	150	ENSP00000392423:A150V;ENSP00000345694:A150V;ENSP00000388446:A150V	ENSP00000345694:A150V	A	-	2	0	RELN	103261244	1	0.714170	0.875000	0.343270	0.980000	0.705560	5.819000	0.692430	2.634000	0.892830	0.650000	0.862430	GCG		TCGA-3A-A9IX-01A-11D-A40W-08	RELN-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000348148.1	1	0	0	13	248	0	33	0	9.889227e-02	0	10	0	33	2		0	0	0	0	0	2	1	9.995367e-01	13	245	0	32	2								-3.200436	1	1	121408	1	30	1	0	0	0	1.975038	0	0.100000	2	0.082569	0.960000	0.550000	1.000000	1.000000	0.896708	0.960000	1	0.730000	1.000000
ATP6V0A4	50617	broad.mit.edu	37	7	138434008	138434008	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr7:138434008C>A	ENST00000310018.2	-	12	1366	c.1084G>T	c.(1084-1086)Gcc>Tcc	p.A362S	ATP6V0A4_ENST00000353492.4_Missense_Mutation_p.A362S|ATP6V0A4_ENST00000393054.1_Missense_Mutation_p.A362S	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4			36					GTGGGAGGGGCTGTTTTAGAT	0.453000																								0							SO:0001583	missense			ENST00000310018.2	0	1	hg19	CCDS5849.1	.	.	.	.	.	.	.	.	.	.	C	5.791000	0.330340	0.109560	.	.	ENSG00000105929	ENST00000310018;ENST00000393054;ENST00000353492	D;D;D	0.85629	-2.01;-2.01;-2.01	5.130000	4.040000	0.470220	.	0.458554	0.21405	N	0.075080	T	0.76572	0.4006	N	0.20445	0.575	0.294150	N	0.860951	B	0.28584	0.216	B	0.34038	0.174	T	0.69412	-0.5152	10	0.25751	T	0.34	-4.7235	14.501700	0.677270	0.0:0.9161:0.0:0.0839	.	362	Q9HBG4	VPP4_HUMAN	S	362	ENSP00000308122:A362S;ENSP00000376774:A362S;ENSP00000253856:A362S	ENSP00000308122:A362S	A	-	1	0	ATP6V0A4	138084548	9.850000e-01	0.353260	0.722000	0.306700	0.078000	0.173710	0.936000	0.289380	2.398000	0.815610	0.561000	0.740990	GCC		TCGA-3A-A9IX-01A-11D-A40W-08	ATP6V0A4-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000347514.1	0	0	0	9	515	0	144	0	0	0	1	0	144	2		0	0	0	0	0	2	1	9.941926e-01	10	512	0	138	2								-2.633148	1	1	0	0		1	0	0	0	1.975038	0	0.100000	2	0.082569	0.340000	0.170000	0.600000	0.340000	0.365108	0.340000	0	0.240000	0.470000
SDK1	221935	broad.mit.edu	37	7	4119186	4119186	+	Silent	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr7:4119186G>A	ENST00000404826.2	+	22	3433	c.3294G>A	c.(3292-3294)acG>acA	p.T1098T	SDK1_ENST00000389531.3_Silent_p.T1098T	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1			153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)			ACGGGAAAACGTCCATCTCCA	0.572000																								0							SO:0001819	synonymous_variant			ENST00000404826.2	0	1	hg19	CCDS34590.1																																																																																				TCGA-3A-A9IX-01A-11D-A40W-08	SDK1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000323702.1	0	0	0	7	475	0	108	0	7.243544e-02	0	26	0	108	2		0	0	0	0	0	2	1	9.792567e-01	7	465	0	108	2								-2.889120	1	1	121412	8	47	1	1	2	3	2.065582	0	0.100000	2	0.119804	0.360000	0.140000	1.000000	0.290000	0.492967	0.360000	0	0.230000	1.000000
CSMD1	64478	broad.mit.edu	37	8	3263557	3263557	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr8:3263557C>T	ENST00000520002.1	-	16	2816	c.2261G>A	c.(2260-2262)cGc>cAc	p.R754H	CSMD1_ENST00000542608.1_Missense_Mutation_p.R753H|CSMD1_ENST00000602557.1_Missense_Mutation_p.R754H|CSMD1_ENST00000537824.1_Missense_Mutation_p.R753H|CSMD1_ENST00000400186.3_Missense_Mutation_p.R754H|CSMD1_ENST00000602723.1_Missense_Mutation_p.R754H|CSMD1_ENST00000539096.1_Missense_Mutation_p.R753H			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1			25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)			ACCTTCACAGCGGGGCACGGT	0.532000																								0							SO:0001583	missense			ENST00000520002.1	0	1	hg19		.	.	.	.	.	.	.	.	.	.	C	31.000000	5.072882	0.939500	.	.	ENSG00000183117	ENST00000400186;ENST00000520002;ENST00000318252;ENST00000537824;ENST00000542608;ENST00000539096	T;T;T;T;T	0.65178	-0.14;-0.14;-0.14;-0.14;-0.14	5.360000	5.360000	0.768440	Complement control module (2);Sushi/SCR/CCP (3);	0.000000	0.85682	D	0.000000	T	0.72309	0.3444	L	0.42008	1.315	0.807220	D	1.000000	D;D	0.89917	1.0;1.0	D;D	0.85130	0.997;0.994	T	0.65364	-0.6186	10	0.15066	T	0.55	.	19.090600	0.932250	0.0:1.0:0.0:0.0	.	754;754	E5RIG2;Q96PZ7	.;CSMD1_HUMAN	H	754;754;616;753;753;753	ENSP00000383047:R754H;ENSP00000430733:R754H;ENSP00000441462:R753H;ENSP00000446243:R753H;ENSP00000441675:R753H	ENSP00000320445:R616H	R	-	2	0	CSMD1	3250964	1	0.714170	1.000000	0.803570	0.840000	0.476710	7.287000	0.786810	2.486000	0.839070	0.591000	0.815410	CGC		TCGA-3A-A9IX-01A-11D-A40W-08	CSMD1-001	KNOWN	basic|appris_candidate_longest	protein_coding	protein_coding	OTTHUMT00000374500.2	1	0	0	11	171	0	26		0	0	0	0	26	2		0	0	0	0	0	2	1	9.983973e-01	11	169	0	25	2								-14.306650	1	1	120896	2	32	1	1	2	3	2.060781	0	0.100000	2	0.131274	0.990000	0.700000	1.000000	1.000000	0.973887	0.990000	1	0.980000	1.000000
FNBP1	23048	broad.mit.edu	37	9	132662311	132662311	+	Silent	SNP	G	G	A	rs138991769	by1000genomes	TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr9:132662311G>A	ENST00000446176.2	-	15	1806	c.1620C>T	c.(1618-1620)gaC>gaT	p.D540D	FNBP1_ENST00000478129.1_5'UTR|FNBP1_ENST00000355681.3_Silent_p.D511D|FNBP1_ENST00000420781.1_Silent_p.D531D|FNBP1_ENST00000443566.2_Silent_p.D168D	NM_015033.2	NP_055848.1	Q96RU3	FNBP1_HUMAN	formin binding protein 1					Ovarian(14;0.000536)			CAAACTCGTCGTCAAAATCCG	0.507000			T	MLL	AML										Dom	yes		9	9q23	23048	formin binding protein 1 (FBP17)		L	0							SO:0001819	synonymous_variant			ENST00000446176.2	0	1	hg19	CCDS48040.1	4	0.0018315018315018315	4	0.008130081300813009	0	0.0	0	0.0	0	0.0	G	7.682000	0.689202	0.149730	0.006121	1.19E-4	ENSG00000187239	ENST00000449089	.	.	.	4.980000	-4.270000	0.037440	.	.	.	.	.	T	0.55049	0.1896	.	.	.	0.807220	D	1.000000	.	.	.	.	.	.	T	0.61608	-0.7028	4	.	.	.	-27.8124	14.352100	0.667110	0.641:0.0:0.359:0.0	.	.	.	.	M	492	.	.	T	-	2	0	FNBP1	131702132	0	0.058580	0.181000	0.230980	0.939000	0.581520	-1.892000	0.016100	-0.781000	0.045480	-0.390000	0.065200	ACG		TCGA-3A-A9IX-01A-11D-A40W-08	FNBP1-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000054630.2	0	0	0	6	362	0	76	0	5.641922e-01	0	106	0	76	2		0	0	0	0	0	2	1	9.618739e-01	6	351	0	73	2								-1.537296	0	1	120952	90	53	1	1	2	3	2.009769	0	0.100000	2	0.107586	0.370000	0.150000	1.000000	0.330000	0.456070	0.370000	0	0.240000	0.670000
CARD9	64170	broad.mit.edu	37	9	139265516	139265516	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chr9:139265516G>A	ENST00000371732.5	-	4	569	c.404C>T	c.(403-405)gCg>gTg	p.A135V	CARD9_ENST00000371734.3_Missense_Mutation_p.A135V|CARD9_ENST00000315908.7_Missense_Mutation_p.A135V	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9			15		Myeloproliferative disorder(178;0.0511)			GCTCAGCAGCGCGGTCAGGTC	0.612000																								0							SO:0001583	missense			ENST00000371732.5	1	1	hg19	CCDS6997.1	.	.	.	.	.	.	.	.	.	.	G	5.443000	0.266829	0.102940	.	.	ENSG00000187796	ENST00000371734;ENST00000371732;ENST00000315908	T;T;T	0.35421	1.31;1.31;1.31	4.720000	1.270000	0.214890	.	0.911173	0.09365	N	0.812180	T	0.19446	0.0467	N	0.17838	0.53	0.093100	N	1.000000	B;B;B;B	0.20261	0.043;0.003;0.01;0.01	B;B;B;B	0.14578	0.011;0.008;0.002;0.002	T	0.24657	-1.0154	10	0.30078	T	0.28	-20.6527	2.460500	0.045400	0.297:0.0:0.2608:0.4422	.	31;135;135;135	B4DIK5;Q9H257-2;Q5SXM5;Q9H257	.;.;.;CARD9_HUMAN	V	135	ENSP00000360799:A135V;ENSP00000360797:A135V;ENSP00000323719:A135V	ENSP00000323719:A135V	A	-	2	0	CARD9	138385337	0	0.058580	0.178000	0.230400	0.090000	0.182700	0.365000	0.203480	0.393000	0.252030	-0.253000	0.114240	GCG		TCGA-3A-A9IX-01A-11D-A40W-08	CARD9-004	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000055053.1	0	0	0	11	147	0	60	0	2.557842e-01	0	13	0	60	2		0	0	0	0	0	2	1	9.983553e-01	11	144	0	60	2								-15.422610	1	1	121150	6	35	1	1	2	3	2.009769	0	0.100000	2	0.107586	0.990000	0.770000	1.000000	1.000000	0.983632	0.990000	1	0.990000	1.000000
CENPI	2491	broad.mit.edu	37	X	100357364	100357364	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chrX:100357364G>T	ENST00000372927.1	+	3	605	c.328G>T	c.(328-330)Gat>Tat	p.D110Y	CENPI_ENST00000218507.5_Missense_Mutation_p.D110Y|CENPI_ENST00000372926.1_Missense_Mutation_p.D110Y|CENPI_ENST00000423383.1_Missense_Mutation_p.D110Y	NM_006733.2	NP_006724.2	Q92674	CENPI_HUMAN	centromere protein I			30					AGAAGAAATTGATATTCTATT	0.313000																								0							SO:0001583	missense			ENST00000372927.1	0	1	hg19	CCDS14479.1	.	.	.	.	.	.	.	.	.	.	G	13.900000	2.375305	0.421050	.	.	ENSG00000102384	ENST00000423383;ENST00000218507;ENST00000372926;ENST00000372927	.	.	.	5.170000	5.170000	0.711590	.	0.166479	0.56097	D	0.000022	T	0.72145	0.3424	M	0.73598	2.24	0.415110	D	0.988343	P;P	0.36144	0.539;0.539	P;P	0.48704	0.587;0.587	T	0.74780	-0.3549	9	0.54805	T	0.06	-13.5932	12.738800	0.572390	0.0:0.1604:0.8396:0.0	.	110;110	B4DZL4;Q92674	.;CENPI_HUMAN	Y	110	.	ENSP00000218507:D110Y	D	+	1	0	CENPI	100244020	9.150000e-01	0.310590	1.000000	0.803570	0.481000	0.331890	2.439000	0.448460	2.276000	0.759620	0.538000	0.681660	GAT		TCGA-3A-A9IX-01A-11D-A40W-08	CENPI-004	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000057519.1	0	0	0	8	388	0	77	0	0	0	1	0	77	2		0	0	0	0	0	2	1	9.882635e-01	8	378	0	76	2								-2.790907	1	1	0	0		1	0	1	1			0.100000	2	0.100000	0.200000	0.090000	0.370000	0.200000	0.220999	0.200000	0	0.140000	0.290000
WWC3	55841	broad.mit.edu	37	X	10102530	10102530	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chrX:10102530A>G	ENST00000380861.4	+	19	3048	c.2657A>G	c.(2656-2658)aAg>aGg	p.K886R	WWC3_ENST00000454666.1_Missense_Mutation_p.K886R	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3			52					AGCCTCGTGAAGGAGCGGCCC	0.547000																								0							SO:0001583	missense			ENST00000380861.4	1	1	hg19	CCDS14136.1	.	.	.	.	.	.	.	.	.	.	A	20.500000	4.002383	0.749320	.	.	ENSG00000047644	ENST00000380861;ENST00000454666;ENST00000543412	T;T	0.58060	0.36;0.36	5.710000	5.710000	0.891250	.	0.089123	0.85682	D	0.000000	T	0.66723	0.2818	M	0.86651	2.83	0.547530	D	0.999982	P	0.47106	0.89	P	0.48304	0.573	T	0.72646	-0.4230	9	.	.	.	-38.9372	15.030700	0.717050	1.0:0.0:0.0:0.0	.	886	Q9ULE0	WWC3_HUMAN	R	886;886;381	ENSP00000370242:K886R;ENSP00000399584:K886R	.	K	+	2	0	WWC3	10062530	1	0.714170	0.957000	0.396320	0.066000	0.163640	8.837000	0.921100	1.932000	0.559930	0.425000	0.283300	AAG		TCGA-3A-A9IX-01A-11D-A40W-08	WWC3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000055725.1	1	0	1	46	379	0	121	1	9.463763e-01	9	33	0	121	2		0	0	0	0	0	2	1	9.999982e-01	45	372	1	119	13								-20.000000	1	1	0	0		1	0	1	1			0.100000	2	0.100000	0.920000	0.740000	1.000000	0.990000	0.916217	0.920000	1	0.840000	0.980000
BRWD3	254065	broad.mit.edu	37	X	79971717	79971717	+	Missense_Mutation	SNP	T	T	A	rs146207659		TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chrX:79971717T>A	ENST00000373275.4	-	20	2480	c.2264A>T	c.(2263-2265)gAc>gTc	p.D755V	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3			87					GATTTCTATGTCACCTTTTGC	0.323000																								0							SO:0001583	missense			ENST00000373275.4	1	1	hg19	CCDS14447.1	.	.	.	.	.	.	.	.	.	.	T	23.200000	4.388054	0.829020	.	.	ENSG00000165288	ENST00000373275	T	0.32753	1.44	5.170000	5.170000	0.711590	.	0.093262	0.64402	D	0.000001	T	0.39384	0.1076	L	0.46614	1.455	0.807220	D	1.000000	P	0.52692	0.955	P	0.52793	0.709	T	0.10405	-1.0631	9	.	.	.	-18.5315	14.125700	0.652190	0.0:0.0:0.0:1.0	.	755	Q6RI45	BRWD3_HUMAN	V	755	ENSP00000362372:D755V	.	D	-	2	0	BRWD3	79858373	1	0.714170	0.998000	0.565050	0.929000	0.565000	6.301000	0.727820	1.910000	0.553030	0.441000	0.289320	GAC		TCGA-3A-A9IX-01A-11D-A40W-08	BRWD3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000057344.1	1	0	0	15	202	0	51	1	1.652521e-01	2	8	0	51	2		0	0	0	0	0	2	1	9.998770e-01	15	199	0	51	2								-6.139802	1	0	0	0		1	0	1	1			0.100000	2	0.100000	0.670000	0.400000	0.950000	0.670000	0.682103	0.670000	0	0.520000	0.830000
BRWD3	254065	broad.mit.edu	37	X	79971738	79971738	+	Missense_Mutation	SNP	T	T	A			TCGA-3A-A9IX-01A-11D-A40W-08	TCGA-3A-A9IX-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7c89b7e9-17d2-4c9c-9d18-525ec4ee555e	d2d39866-9aa7-4bd7-875d-cd3f1337f21c	g.chrX:79971738T>A	ENST00000373275.4	-	20	2459	c.2243A>T	c.(2242-2244)gAa>gTa	p.E748V	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3			87					AGTTCGACATTCTTCCTGTAC	0.299000																								0							SO:0001583	missense			ENST00000373275.4	1	1	hg19	CCDS14447.1	.	.	.	.	.	.	.	.	.	.	T	15.040000	2.715517	0.486220	.	.	ENSG00000165288	ENST00000373275	T	0.32515	1.45	5.170000	5.170000	0.711590	.	0.046697	0.85682	D	0.000000	T	0.36331	0.0963	M	0.74258	2.255	0.487620	D	0.999702	B	0.27068	0.167	B	0.29598	0.104	T	0.15636	-1.0430	9	.	.	.	-9.7094	14.125700	0.652190	0.0:0.0:0.0:1.0	.	748	Q6RI45	BRWD3_HUMAN	V	748	ENSP00000362372:E748V	.	E	-	2	0	BRWD3	79858394	1	0.714170	1.000000	0.803570	0.851000	0.484510	4.488000	0.603000	1.910000	0.553030	0.441000	0.289320	GAA		TCGA-3A-A9IX-01A-11D-A40W-08	BRWD3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000057344.1	1	0	0	15	178	0	48	1	2.591098e-01	5	7	0	48	2		0	0	0	0	0	2	1	9.998788e-01	15	175	0	47	2								-6.866793	1	0	0	0		1	0	1	1			0.100000	2	0.100000	0.730000	0.440000	0.980000	0.750000	0.737319	0.730000	0	0.580000	0.890000
