Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BTN2A3P	0	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													8	369					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803629	142803629	+	RNA	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:142803629G>A	ENST00000423385.1	-	0	1336																											actaatatctgttgagtgttg	0.308000													7	204					0	0	1	0	0
CAB39L	81617	broad.mit.edu	37	13	49951138	49951138	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr13:49951138T>C	ENST00000355854.4	-	3	738	c.241A>G	c.(241-243)Aca>Gca	p.T81A	CAB39L_ENST00000410043.1_Missense_Mutation_p.T81A|CAB39L_ENST00000347776.5_Missense_Mutation_p.T81A|CAB39L_ENST00000409308.1_Missense_Mutation_p.T81A	NM_030925.2	NP_112187.2	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	81					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding			breast(1)|endometrium(2)|large_intestine(4)|lung(3)|pancreas(1)|stomach(1)	12		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		GCTATCAGTGTCACTAGCAGG	0.433000													210	367					0	0	1	0	0
MIR129-2	0	broad.mit.edu	37	11	43602960	43602960	+	RNA	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr11:43602960T>C	ENST00000362207.1	+	0	17					NR_029697.1																						TCGCGAATCTTTTTGCGGTCT	0.592000													82	12					0	0	1	0	0
ZMYND19	116225	broad.mit.edu	37	9	140481540	140481540	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:140481540C>A	ENST00000298585.2	-	4	464	c.238G>T	c.(238-240)Gtg>Ttg	p.V80L	ZMYND19_ENST00000471957.1_5'UTR	NM_138462.2	NP_612471.1	Q96E35	ZMY19_HUMAN	zinc finger, MYND-type containing 19	80						Golgi apparatus|plasma membrane	zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	13	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000275)|Epithelial(140;0.00047)		CCCGGGGCCACGCCCCCCCGG	0.632000													5	465					0.27861	0.27861	1	1	0
RRN3P2	0	broad.mit.edu	37	16	29088081	29088081	+	RNA	SNP	C	C	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr16:29088081C>A	ENST00000564580.1	+	0	251																											AAGTACAAAACGGTAAGAGGA	0.358000													4	214					0.00116845	0.00119456	1	1	0
SNX32	254122	broad.mit.edu	37	11	65618619	65618619	+	Missense_Mutation	SNP	C	C	T	rs147615662	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr11:65618619C>T	ENST00000308342.6	+	7	1122	c.697C>T	c.(697-699)Cgc>Tgc	p.R233C		NM_152760.2	NP_689973.2	Q86XE0	SNX32_HUMAN	sorting nexin 32	233					cell communication|protein transport		phosphatidylinositol binding	p.R233C(1)		endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				READ - Rectum adenocarcinoma(159;0.171)		CCGCGTCATGCGCGCCCACAA	0.632000											OREG0021087	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	478					0	0	1	0	0
KLRC4-KLRK1	0	broad.mit.edu	37	12	10561520	10561520	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:10561520G>A	ENST00000539300.1	-	2	250	c.251C>T	c.(250-252)tCt>tTt	p.S84F	KLRC4_ENST00000309384.1_Missense_Mutation_p.L93F																							CAAGGAATAAGAACTATTGTT	0.383000													120	325					0	0	1	0	0
ZNF28	7576	broad.mit.edu	37	19	53304126	53304126	+	Silent	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:53304126C>T	ENST00000438150.2	-	2	1706	c.813G>A	c.(811-813)ggG>ggA	p.G271G	ZNF28_ENST00000414252.2_Silent_p.G271G|ZNF28_ENST00000457749.2_Silent_p.G324G|ZNF28_ENST00000360272.4_Silent_p.G271G			P17035	ZNF28_HUMAN	zinc finger protein 28	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TGTATGGTTTCCCTCCAGTAT	0.353000													166	359					0	0	1	0	0
SLC25A6	293	broad.mit.edu	37	X	1508304	1508304	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chrX:1508304G>A	ENST00000381401.5	-	2	1142	c.428C>T	c.(427-429)gCg>gTg	p.A143V	SLC25A6_ENST00000475167.1_5'UTR	NM_001636.3	NP_001627.2	P12236	ADT3_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	143					active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|upper_aerodigestive_tract(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	TCCCACGTCCGCTGCCAGGCG	0.672000													6	537					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229773136	229773136	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:229773136G>A	ENST00000258243.2	+	4	2912	c.2776G>A	c.(2776-2778)Gtc>Atc	p.V926I		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	926						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						GTCCATGGCCGTCACCAAACT	0.483000													6	763					0	0	1	0	0
ACY3	91703	broad.mit.edu	37	11	67410228	67410228	+	Silent	SNP	G	G	A	rs149837610		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr11:67410228G>A	ENST00000255082.3	-	8	1097	c.927C>T	c.(925-927)ccC>ccT	p.P309P	ACY3_ENST00000529256.1_Silent_p.P188P	NM_080658.1	NP_542389.1	Q96HD9	ACY3_HUMAN	aspartoacylase (aminocyclase) 3	309					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding			endometrium(1)|lung(5)|prostate(2)	8					L-Aspartic Acid(DB00128)	GGGTCAGCGCGGGCATGGCAG	0.587000													6	341					0	0	1	0	0
CNN2	1265	broad.mit.edu	37	19	1037794	1037794	+	Silent	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:1037794G>A	ENST00000263097.4	+	7	1188	c.825G>A	c.(823-825)ccG>ccA	p.P275P	CNN2_ENST00000348419.3_Silent_p.P236P|CNN2_ENST00000565096.2_Silent_p.P264P|CNN2_ENST00000562958.2_Silent_p.P296P|CNN2_ENST00000606983.1_3'UTR	NM_004368.2	NP_004359.1	Q99439	CNN2_HUMAN	calponin 2	275					actomyosin structure organization|cellular response to mechanical stimulus|regulation of actin filament-based process	cell-cell junction|stress fiber	actin binding|calmodulin binding			endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTACTGCCCGCAAGGCACAG	0.672000													8	954					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186442938	186442938	+	Silent	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr3:186442938G>A	ENST00000265023.4	+	4	665	c.453G>A	c.(451-453)acG>acA	p.T151T	RP11-573D15.8_ENST00000599314.1_RNA|KNG1_ENST00000447445.1_Silent_p.T151T|KNG1_ENST00000287611.2_Silent_p.T151T	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	151	Cystatin 2.|O-glycosylated at one site only.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	CTATATCAACGCAGAGCCCAG	0.493000													4	180					0	0	1	0	0
RNF114	55905	broad.mit.edu	37	20	48561967	48561967	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:48561967C>G	ENST00000244061.2	+	3	342	c.340C>G	c.(340-342)Cag>Gag	p.Q114E		NM_018683.3	NP_061153.1	Q9Y508	RN114_HUMAN	ring finger protein 114	114					cell differentiation|multicellular organismal development|spermatogenesis	intracellular	zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(1)|ovary(1)	5						TTCCAAATACCAGAATTACAT	0.478000													150	215					0	0	1	0	0
LPIN3	64900	broad.mit.edu	37	20	39978499	39978499	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:39978499T>C	ENST00000373257.3	+	6	815	c.724T>C	c.(724-726)Tcc>Ccc	p.S242P		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	242					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				AAGAGCCGAGTCCCACATGCA	0.642000													10	381					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													8	309					0	0	1	0	0
SPATA22	84690	broad.mit.edu	37	17	3370783	3370783	+	Missense_Mutation	SNP	G	G	T	rs145051415	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:3370783G>T	ENST00000573128.1	-	3	592	c.109C>A	c.(109-111)Ctt>Att	p.L37I	SPATA22_ENST00000268981.5_Missense_Mutation_p.L37I|SPATA22_ENST00000397168.3_Missense_Mutation_p.L37I|SPATA22_ENST00000572969.1_Missense_Mutation_p.L37I|SPATA22_ENST00000575375.1_Missense_Mutation_p.L37I|SPATA22_ENST00000355380.4_Intron|SPATA22_ENST00000541913.1_Missense_Mutation_p.L37I			Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	37										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)	19						TCATCTTTAAGTGGATTAGAA	0.328000													141	458					3.7336e-74	4.21758e-74	1	1	0
ZNF479	90827	broad.mit.edu	37	7	57187780	57187780	+	Missense_Mutation	SNP	A	A	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:57187780A>C	ENST00000331162.4	-	5	1612	c.1342T>G	c.(1342-1344)Tta>Gta	p.L448V		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			GTTGAGGATAAGCTAAAGGCT	0.438000													8	827					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664186	22664186	+	RNA	SNP	A	A	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr22:22664186A>G	ENST00000426066.1	+	0	709					NR_027293.1																						CAGATCAAGAAAGCACTCTGA	0.498000													6	180					0	0	1	0	0
SPZ1	84654	broad.mit.edu	37	5	79616605	79616605	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:79616605C>G	ENST00000296739.4	+	1	816	c.571C>G	c.(571-573)Cag>Gag	p.Q191E		NM_032567.3	NP_115956.3	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(5)|large_intestine(4)|lung(12)|ovary(1)|skin(2)	26		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		AAAGAAACAGCAGATGATAAT	0.353000													5	431					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628273	29628273	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:29628273A>G	ENST00000278882.3	+	6	655	c.275A>G	c.(274-276)aAt>aGt	p.N92S	FRG1B_ENST00000358464.4_Missense_Mutation_p.N92S|FRG1B_ENST00000439954.2_Missense_Mutation_p.N97S																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATTAGATGCAATGAAGCAGGG	0.373000													6	715					0	0	1	0	0
ZNF799	90576	broad.mit.edu	37	19	12501560	12501560	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:12501560T>C	ENST00000419318.1	-	4	2305	c.1556A>G	c.(1555-1557)gAa>gGa	p.E519G	CTD-3105H18.14_ENST00000435033.1_Intron|ZNF799_ENST00000430385.3_Missense_Mutation_p.E551G			Q96GE5	ZN799_HUMAN	zinc finger protein 799	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						GTGAATTCTTTCATGTCGTAG	0.393000													5	592					0	0	1	0	0
HSPA1A	3303	broad.mit.edu	37	6	31785295	31785295	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:31785295G>A	ENST00000375651.5	+	1	2005	c.1762G>A	c.(1762-1764)Gag>Aag	p.E588K	HSPA1A_ENST00000458062.2_Missense_Mutation_p.E497K	NM_005345.5	NP_005336.3	P08107	HSP71_HUMAN	heat shock 70kDa protein 1A	588					anti-apoptosis|mRNA catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|protein refolding|response to unfolded protein	cytosol|endoplasmic reticulum|inclusion body|mitochondrion|nuclear speck|perinuclear region of cytoplasm|ribonucleoprotein complex	ATP binding|protein binding involved in protein folding|protein N-terminus binding|receptor activity|ubiquitin protein ligase binding|unfolded protein binding			endometrium(1)|ovary(1)|stomach(1)	3						CACCTTGGCCGAGAAGGACGA	0.607000													115	63					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72937715	72937715	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:72937715C>A	ENST00000328801.4	+	2	301	c.301C>A	c.(301-303)Ctg>Atg	p.L101M		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	101						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					TGTGGTGTTCCTGGGTGGCGC	0.622000													166	105					1.07822e-63	1.20313e-63	1	1	0
RRAD	6236	broad.mit.edu	37	16	66956180	66956180	+	Silent	SNP	C	C	A	rs139165037		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr16:66956180C>A	ENST00000299759.6	-	5	976	c.726G>T	c.(724-726)gcG>gcT	p.A242A	RRAD_ENST00000420652.1_Silent_p.A242A			P55042	RAD_HUMAN	Ras-related associated with diabetes	242					small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|urinary_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		CTTCAAACAGCGCCTGGACAT	0.622000													163	31					7.08382e-60	7.8566e-60	1	1	0
PFAS	5198	broad.mit.edu	37	17	8157542	8157542	+	Silent	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:8157542C>T	ENST00000314666.6	+	3	334	c.201C>T	c.(199-201)ccC>ccT	p.P67P	PFAS_ENST00000545834.1_5'UTR	NM_012393.2	NP_036525.1	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	67					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TTGGTTGCCCCTTACTGCTGG	0.602000													9	460					0	0	1	0	0
CCDC71L	168455	broad.mit.edu	37	7	106300652	106300652	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:106300652G>A	ENST00000523505.1	-	1	790	c.691C>T	c.(691-693)Ccg>Tcg	p.P231S		NM_175884.4	NP_787080.2	Q8N9Z2	YG034_HUMAN	coiled-coil domain containing 71-like	231										endometrium(1)	1						CGGGGCACCGGGAAGCGGCGG	0.726000											OREG0018261	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	42					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S|FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													16	800					0	0	1	0	0
NSUN5	55695	broad.mit.edu	37	7	72722532	72722532	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:72722532C>T	ENST00000428206.1	-	2	125	c.112G>A	c.(112-114)Gcg>Acg	p.A38T	NSUN5_ENST00000252594.6_Missense_Mutation_p.A38T|NSUN5_ENST00000438747.2_Missense_Mutation_p.A38T|NSUN5_ENST00000310326.8_Missense_Mutation_p.A38T	NM_001168348.1	NP_001161820.1	Q96P11	NSUN5_HUMAN	NOP2/Sun domain family, member 5	38							methyltransferase activity			breast(1)|endometrium(3)|large_intestine(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	8		Lung NSC(55;0.163)				CACACCAGCGCGTACAGCTGC	0.716000													19	486					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37927910	37927910	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:37927910C>T	ENST00000199447.4	+	15	1651	c.1279C>T	c.(1279-1281)Ccg>Tcg	p.P427S	NME8_ENST00000440017.1_Missense_Mutation_p.P427S|EPDR1_ENST00000476620.1_Intron	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	427	NDK 2.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										GGACAGTTTGCCGGTCAACCA	0.368000													7	465					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													8	170					0	0	1	0	0
METTL4	64863	broad.mit.edu	37	18	2566951	2566951	+	Nonsense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr18:2566951G>A	ENST00000319888.6	-	2	1063	c.265C>T	c.(265-267)Cga>Tga	p.R89*	METTL4_ENST00000574538.1_Nonsense_Mutation_p.R89*			Q8N3J2	METL4_HUMAN	methyltransferase like 4	89					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						AGTTCAGGTCGAAAAACAAAT	0.378000													89	358					0	0	1	0	0
CHERP	10523	broad.mit.edu	37	19	16636214	16636214	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:16636214G>A	ENST00000546361.2	-	10	1731	c.1580C>T	c.(1579-1581)cCg>cTg	p.P527L	CHERP_ENST00000544299.1_5'UTR|CTD-3222D19.2_ENST00000409035.1_Intron|CHERP_ENST00000198939.6_Missense_Mutation_p.P538L	NM_006387.5	NP_006378.3	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum protein	527	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|stomach(1)|urinary_tract(3)	24						CTGGTGGGGCGGGAAGGGCCC	0.726000													3	37					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156843643	156843643	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:156843643G>A	ENST00000368196.3	+	8	1189	c.1069G>A	c.(1069-1071)Ggc>Agc	p.G357S	NTRK1_ENST00000358660.3_Missense_Mutation_p.G357S|NTRK1_ENST00000524377.1_Missense_Mutation_p.G357S|NTRK1_ENST00000392302.2_Missense_Mutation_p.G327S	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	357	Ig-like C2-type 2.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CGTCAACAACGGCAACTACAC	0.622000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			18	48					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237840	29237840	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr14:29237840C>T	ENST00000382535.3	+	2	1724	c.1355C>T	c.(1354-1356)cCc>cTc	p.P452L	FOXG1_ENST00000313071.4_Missense_Mutation_p.P452L			P55316	FOXG1_HUMAN	forkhead box G1	452					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		TCGACCCTGCCCTGTGAGTCT	0.592000													97	406					0	0	1	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72663998	72663998	+	RNA	SNP	T	T	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:72663998T>G	ENST00000425256.1	-	0	902					NR_002164.1																						ATAGCCGGGGTCCTTGAATAC	0.488000													5	358					0	0	1	0	0
PCDHB16	0	broad.mit.edu	37	5	140563238	140563238	+	Silent	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:140563238C>T	ENST00000361016.2	+	1	2259	c.1104C>T	c.(1102-1104)ttC>ttT	p.F368F		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		368	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTGCTGTTTTCAGCGTTTCAG	0.493000													8	442					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86266503	86266503	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:86266503G>A	ENST00000394518.2	+	26	6792	c.6697G>A	c.(6697-6699)Gta>Ata	p.V2233I	AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000361243.2_Missense_Mutation_p.V2237I|AKAP13_ENST00000394510.2_Missense_Mutation_p.V478I	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	2233	Interaction with ESR1.|PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GAAGAAGCTTGTACGTGATGG	0.423000													112	135					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79033053	79033053	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:79033053C>T	ENST00000446378.2	+	2	8496	c.8465C>T	c.(8464-8466)tCa>tTa	p.S2822L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2822						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ACTCTTGCTTCAGGAGCTTCT	0.398000													155	81					0	0	1	0	0
IGHV4OR15-8	0	broad.mit.edu	37	15	22473333	22473333	+	RNA	SNP	A	A	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:22473333A>G	ENST00000557788.2	-	0	20																											CCAGGAGGAGAAAGAACCACA	0.512000													10	310					0	0	1	0	0
PBX4	80714	broad.mit.edu	37	19	19672926	19672926	+	Splice_Site	SNP	C	C	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:19672926C>A	ENST00000251203.8	-	8	1319	c.1032_splice	c.e8-1	p.A345_splice		NM_025245.2	NP_079521.1	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	345							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(4)|ovary(1)|prostate(3)	9						CTACCCTGGGCCTGAAACGAC	0.622000													13	61					1.5842e-08	1.68552e-08	1	1	0
TUBB8P7	0	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr16:90162513T>C	ENST00000564451.1	+	0	1866				TUBB8P7_ENST00000567960.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													7	352					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84092916	84092916	+	Missense_Mutation	SNP	G	G	A	rs139138066		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr16:84092916G>A	ENST00000343411.3	-	21	3317	c.2822C>T	c.(2821-2823)aCg>aTg	p.T941M		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	941					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CCTGGGCGCCGTCTCGTTTAA	0.532000													5	253					0	0	1	0	0
CCDC130	81576	broad.mit.edu	37	19	13873869	13873869	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:13873869C>T	ENST00000586600.1	+	11	1681	c.1178C>T	c.(1177-1179)tCg>tTg	p.S393L	CCDC130_ENST00000221554.8_Missense_Mutation_p.S393L			P13994	CC130_HUMAN	coiled-coil domain containing 130	393					response to virus		protein binding			endometrium(2)|kidney(1)|large_intestine(3)|ovary(1)|skin(2)|urinary_tract(1)	10			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)			TACTCCGACTCGGAGAGTGAG	0.697000													30	124					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856761	53856761	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:53856761T>C	ENST00000458035.1	+	4	2950	c.2833T>C	c.(2833-2835)Tgt>Cgt	p.C945R	ZNF845_ENST00000595091.1_Missense_Mutation_p.C945R	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	945					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.C945R(1)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						ACCTTACAAGTGTAATGAATG	0.348000													8	177					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39882017	39882017	+	Silent	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:39882017C>T	ENST00000260356.5	+	13	2103	c.1938C>T	c.(1936-1938)ccC>ccT	p.P646P		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	646	EGF-like 3.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding	p.P646P(1)		breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TGTGCAAGCCCCGTAACCCCT	0.537000													41	81					0	0	1	0	0
MSR1	0	broad.mit.edu	37	8	15967629	15967629	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr8:15967629G>A	ENST00000350896.3	-	9	1329	c.1132C>T	c.(1132-1134)Cat>Tat	p.H378Y	MSR1_ENST00000262101.5_Missense_Mutation_p.H441Y|MSR1_ENST00000445506.2_Missense_Mutation_p.H459Y|MSR1_ENST00000355282.2_Missense_Mutation_p.H378Y	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	441	SRCR.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TCTTCAGAATGTGAACAGGCT	0.373000													5	365					0	0	1	0	0
ALDH1B1	219	broad.mit.edu	37	9	38396889	38396889	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:38396889G>A	ENST00000377698.3	+	2	1297	c.1144G>A	c.(1144-1146)Gca>Aca	p.A382T		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	382					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	GAAGGAGGGCGCAAAACTCCT	0.567000													5	443					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152786392	152786392	+	Splice_Site	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:152786392C>T	ENST00000367255.5	-	18	2534		c.e18+1		SYNE1_ENST00000265368.4_Splice_Site|SYNE1_ENST00000367253.4_Splice_Site|SYNE1_ENST00000423061.1_Splice_Site|SYNE1_ENST00000448038.1_Splice_Site|SYNE1_ENST00000413186.2_Splice_Site|SYNE1_ENST00000367248.3_Splice_Site|SYNE1_ENST00000495090.2_Splice_Site|SYNE1_ENST00000341594.5_Splice_Site|SYNE1_ENST00000466159.2_Splice_Site	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACCAATCTTACCTTTTTGGCA	0.403000										HNSCC(10;0.0054)			220	38					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169506095	169506095	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:169506095G>A	ENST00000256935.8	+	49	5191	c.5111G>A	c.(5110-5112)aGa>aAa	p.R1704K	DOCK2_ENST00000520908.1_Missense_Mutation_p.R1196K|DOCK2_ENST00000540750.1_Missense_Mutation_p.R765K|DOCK2_ENST00000523351.1_3'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1704					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGGACAAAGAGAAGCAGCGTA	0.587000													175	115					0	0	1	0	0
GOLGA6L5	0	broad.mit.edu	37	15	85053124	85053124	+	RNA	SNP	G	G	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:85053124G>T	ENST00000414190.2	-	0	328					NR_003246.2																						TAAATGTTTTGTTTTTTTTTT	0.353000													13	35					3.32936e-07	3.50157e-07	1	1	0
KCNA6	3742	broad.mit.edu	37	12	4919970	4919970	+	Missense_Mutation	SNP	G	G	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:4919970G>C	ENST00000433855.1	+	1	1629	c.763G>C	c.(763-765)Ggg>Cgg	p.G255R	KCNA6_ENST00000280684.3_Missense_Mutation_p.G255R	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	255						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						CAGTACTCTTGGGGGCTCCTT	0.552000										HNSCC(72;0.22)			266	173					0	0	1	0	0
POM121L9P	0	broad.mit.edu	37	22	24659734	24659734	+	RNA	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr22:24659734T>C	ENST00000414583.2	+	0	3259					NR_003714.1																						CTCTCTCCTGTGGGAGGGGGG	0.632000													6	54					0	0	1	0	0
UGT1A9	0	broad.mit.edu	37	2	234581034	234581034	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr2:234581034A>G	ENST00000354728.4	+	1	536	c.454A>G	c.(454-456)Aac>Gac	p.N152D	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A10_ENST00000373445.1_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		TCCTTTTGATAACTGTGGCTT	0.398000													6	472					0	0	1	0	0
NBPF15	284565	broad.mit.edu	37	1	148594434	148594434	+	Missense_Mutation	SNP	G	G	A	rs143361250	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:148594434G>A	ENST00000442702.2	+	21	2874	c.1807G>A	c.(1807-1809)Gtc>Atc	p.V603I	NBPF15_ENST00000369187.3_Missense_Mutation_p.V603I	NM_001170755.1	NP_001164226.1	Q8N660	NBPFF_HUMAN	neuroblastoma breakpoint family, member 15	603	NBPF 6.					cytoplasm				NS(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12	all_hematologic(923;0.032)					AGAGCCTGAAGTCTTACAGGA	0.458000													14	1173					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128844810	128844810	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr11:128844810C>T	ENST00000310343.9	-	20	2239	c.2240G>A	c.(2239-2241)cGc>cAc	p.R747H	ARHGAP32_ENST00000524655.1_Missense_Mutation_p.R673H|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.R398H|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.R398H	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	747					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GGAGTTACAGCGGTTCCCCAG	0.478000													5	211					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152650992	152650992	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:152650992G>A	ENST00000367255.5	-	78	15429	c.14828C>T	c.(14827-14829)gCg>gTg	p.A4943V	SYNE1_ENST00000265368.4_Missense_Mutation_p.A4943V|SYNE1_ENST00000423061.1_Missense_Mutation_p.A4872V|SYNE1_ENST00000448038.1_Missense_Mutation_p.A4872V|SYNE1_ENST00000341594.5_Missense_Mutation_p.A4690V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4943					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTGACTCAGCGCATTCATGAT	0.488000										HNSCC(10;0.0054)			7	870					0	0	1	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276945	71276945	+	Silent	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr11:71276945T>C	ENST00000398531.1	+	1	337	c.312T>C	c.(310-312)tgT>tgC	p.C104C	KRTAP5-10_ENST00000376536.4_Intron	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	104	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						AGGGGGGCTGTGGTTCTTGTG	0.677000													5	236					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162172	90162172	+	RNA	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr16:90162172T>C	ENST00000564451.1	+	0	1525				TUBB8P7_ENST00000567960.1_RNA																							GATGGCTGCCTGTGACCCCCG	0.567000													12	270					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96805579	96805579	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr10:96805579G>A	ENST00000371270.3	-	6	1043	c.949C>T	c.(949-951)Cca>Tca	p.P317S	CYP2C8_ENST00000535898.1_Missense_Mutation_p.P215S|CYP2C8_ENST00000539050.1_Missense_Mutation_p.P231S	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	317					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	GTGACCTCTGGGTGCTTCAGC	0.458000													130	241					0	0	1	0	0
RANBP9	10048	broad.mit.edu	37	6	13711709	13711709	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:13711709G>T	ENST00000011619.3	-	1	87	c.29C>A	c.(28-30)cCg>cAg	p.P10Q		NM_005493.2	NP_005484.2	Q96S59	RANB9_HUMAN	RAN binding protein 9	10	Poly-Pro.				axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	16	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			ctgctgctgcggcggcggcgg	0.761000													3	35					0.00024832	0.000255295	1	1	0
ZNF709	163051	broad.mit.edu	37	19	12575498	12575498	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:12575498G>A	ENST00000397732.3	-	4	1409	c.1238C>T	c.(1237-1239)aCt>aTt	p.T413I	CTD-3105H18.18_ENST00000598753.1_Intron|ZNF709_ENST00000428311.1_Missense_Mutation_p.T413I	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.T413I(2)		large_intestine(3)|upper_aerodigestive_tract(3)	6						TCCAGTGTGAGTTCTTTCATG	0.418000													11	1003					0	0	1	0	0
FRG1	2483	broad.mit.edu	37	4	190883052	190883052	+	Silent	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:190883052G>A	ENST00000226798.4	+	8	927	c.705G>A	c.(703-705)cgG>cgA	p.R235R		NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	235					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		AAAAGGCTCGGAAAGATGGAT	0.328000													9	1346					0	0	1	0	0
HIST1H2BJ	8970	broad.mit.edu	37	6	27100369	27100369	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:27100369C>T	ENST00000607124.1	-	1	160	c.161G>A	c.(160-162)gGc>gAc	p.G54D	HIST1H2BJ_ENST00000339812.2_Missense_Mutation_p.G54D|HIST1H2BJ_ENST00000541790.1_Missense_Mutation_p.G54D			P06899	H2B1J_HUMAN	histone cluster 1, H2bj	54					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding	p.G54D(2)		breast(1)|kidney(2)|lung(5)|ovary(1)|prostate(1)	10						GGACGAAATGCCGGTGTCAGG	0.547000													9	733					0	0	1	0	0
DISP1	84976	broad.mit.edu	37	1	223176649	223176649	+	Missense_Mutation	SNP	C	C	T	rs148231227	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:223176649C>T	ENST00000284476.6	+	8	2074	c.1910C>T	c.(1909-1911)gCg>gTg	p.A637V		NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	637	SSD.				diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity	p.A637V(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		GGGGTTTATGCGGGGACAGCT	0.448000													5	537					0	0	1	0	0
HTR3D	200909	broad.mit.edu	37	3	183756704	183756704	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr3:183756704C>T	ENST00000382489.3	+	8	1306	c.1306C>T	c.(1306-1308)Ctc>Ttc	p.L436F	HTR3D_ENST00000428798.2_Missense_Mutation_p.L386F|HTR3D_ENST00000453435.1_Missense_Mutation_p.L215F|HTR3D_ENST00000334128.2_Missense_Mutation_p.L261F	NM_001163646.1	NP_001157118.1	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	436						integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)	10	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCTCTTCCGCCTCTACCTGCT	0.582000													295	57					0	0	1	0	0
RASGEF1B	153020	broad.mit.edu	37	4	82377910	82377910	+	Silent	SNP	A	A	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:82377910A>G	ENST00000436139.2	-	4	459	c.333T>C	c.(331-333)ctT>ctC	p.L111L	RASGEF1B_ENST00000509081.1_Silent_p.L111L|RASGEF1B_ENST00000514889.1_5'UTR|RASGEF1B_ENST00000264400.2_Silent_p.L111L|RASGEF1B_ENST00000335927.7_Silent_p.L70L			Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	111	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			endometrium(2)|kidney(5)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	26						TGAGGAGTTGAAGGATTTTGG	0.388000													5	452					0	0	1	0	0
SUZ12	23512	broad.mit.edu	37	17	30267331	30267331	+	Nonsense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:30267331C>T	ENST00000322652.5	+	2	530	c.301C>T	c.(301-303)Cga>Tga	p.R101*	SUZ12_ENST00000580398.1_Nonsense_Mutation_p.R101*	NM_015355.2	NP_056170.2	Q15022	SUZ12_HUMAN	SUZ12 polycomb repressive complex 2 subunit	101					negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding	p.R101*(1)	SSH2/SUZ12(2)|JAZF1/SUZ12(133)	breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(5)|skin(1)	21		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				TAGATTTCTTCGAACTCGGAA	0.308000			T	JAZF1	endometrial stromal tumours								6	783					0	0	1	0	0
ZNF429	353088	broad.mit.edu	37	19	21720414	21720414	+	Missense_Mutation	SNP	T	T	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:21720414T>G	ENST00000358491.4	+	4	1767	c.1559T>G	c.(1558-1560)cTg>cGg	p.L520R	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	520					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						GCTTTTATCCTGTCCTCAAGA	0.378000													8	562					0	0	1	0	0
SUN1	23353	broad.mit.edu	37	7	897583	897583	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:897583G>A	ENST00000456758.2	+	19	2080	c.2080G>A	c.(2080-2082)Gta>Ata	p.V694I	SUN1_ENST00000425407.2_Missense_Mutation_p.V422I|SUN1_ENST00000401592.1_Missense_Mutation_p.V505I|SUN1_ENST00000389574.3_Missense_Mutation_p.V422I|SUN1_ENST00000452783.2_Missense_Mutation_p.V402I|SUN1_ENST00000405266.1_Missense_Mutation_p.V542I|SUN1_ENST00000413514.2_Missense_Mutation_p.V303I			O94901	SUN1_HUMAN	Sad1 and UNC84 domain containing 1	532	SUN.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AGTGGATGCCGTACAAGAAAG	0.438000													8	876					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625934	29625934	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:29625934C>T	ENST00000278882.3	+	5	558	c.178C>T	c.(178-180)Cat>Tat	p.H60Y	FRG1B_ENST00000358464.4_Missense_Mutation_p.H60Y|FRG1B_ENST00000439954.2_Missense_Mutation_p.H65Y																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ACTTGTTGGGCATTCAGATGC	0.338000													14	597					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													7	431					0	0	1	0	0
ZNF366	0	broad.mit.edu	37	5	71752377	71752377	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:71752377G>T	ENST00000318442.5	-	3	1868	c.1378C>A	c.(1378-1380)Ctg>Atg	p.L460M		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		TTGGCCAGCAGGGTGAACTCC	0.532000													7	726					0.00198382	0.00201688	1	1	0
CYP4F24P	0	broad.mit.edu	37	19	15882884	15882884	+	RNA	SNP	C	C	T	rs3752144	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:15882884C>T	ENST00000587443.2	-	0	793					NR_033864.1																						TGCATTTCTGCAGACTGTCCA	0.537000													8	683					0	0	1	0	0
IGHV3-43	0	broad.mit.edu	37	14	106926420	106926420	+	RNA	SNP	C	C	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr14:106926420C>A	ENST00000434710.1	-	0	201																											AGAGGCTGCACAGGAGAGTCT	0.567000													380	512					4.6437e-136	5.34464e-136	1	1	0
METTL17	64745	broad.mit.edu	37	14	21464862	21464862	+	Silent	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr14:21464862G>A	ENST00000339374.6	+	13	1490	c.1257G>A	c.(1255-1257)cgG>cgA	p.R419R	METTL17_ENST00000556670.2_Silent_p.R419R|METTL17_ENST00000382985.4_Silent_p.R419R|RP11-84C10.4_ENST00000557335.1_RNA	NM_001029991.1|NM_022734.2	NP_001025162.1|NP_073571.1	Q9H7H0	MET17_HUMAN	methyltransferase like 17	419					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20						CAGCCCGCCGGCACGGCAGGT	0.582000													5	577					0	0	1	0	0
LINC00264	0	broad.mit.edu	37	10	26880338	26880338	+	RNA	SNP	G	G	C	rs3118888	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr10:26880338G>C	ENST00000412114.1	+	0	573					NR_026793.1																						GCTGAAACATGGAAGGTAAAA	0.483000													6	118					0	0	1	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74368296	74368296	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:74368296G>A	ENST00000290438.3	-	8	635	c.595C>T	c.(595-597)Cgg>Tgg	p.R199W		NM_001038640.2	NP_001033729.2	Q9NYA3	GOG6A_HUMAN	golgin A6 family, member A	199										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|liver(1)|lung(6)|prostate(1)|urinary_tract(1)	16						TGTAACCACCGCTGGAGGACC	0.572000													9	1037					0	0	1	0	0
CHD6	0	broad.mit.edu	37	20	40049225	40049225	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:40049225C>T	ENST00000373233.3	-	31	6227	c.6050G>A	c.(6049-6051)gGa>gAa	p.G2017E		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2017					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				GAGCTCACTTCCTTCAAGAGG	0.403000													91	339					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12888459	12888459	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:12888459C>T	ENST00000535591.1	-	2	260	c.65G>A	c.(64-66)cGc>cAc	p.R22H		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	22										NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						AGGGAGGCGGCGGAAGGGCCA	0.612000													5	245					0	0	1	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65350232	65350232	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:65350232A>G	ENST00000284037.5	+	21	3475	c.3086A>G	c.(3085-3087)aAt>aGt	p.N1029S	ERBB2IP_ENST00000508515.1_Missense_Mutation_p.N1029S|ERBB2IP_ENST00000380936.1_Missense_Mutation_p.N1029S|ERBB2IP_ENST00000416865.2_Intron|ERBB2IP_ENST00000380935.1_Missense_Mutation_p.N1029S|ERBB2IP_ENST00000380938.2_Missense_Mutation_p.N1029S|ERBB2IP_ENST00000506030.1_Missense_Mutation_p.N1029S|ERBB2IP_ENST00000511297.1_Missense_Mutation_p.N1025S|ERBB2IP_ENST00000380939.2_Missense_Mutation_p.N1029S|ERBB2IP_ENST00000380943.2_Missense_Mutation_p.N1029S	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	1029					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		GCCAATATGAATTTCTCTAAT	0.418000													94	222					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								8	167					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96594840	96594840	+	Missense_Mutation	SNP	T	T	C	rs76434426	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr2:96594840T>C	ENST00000456556.1	-	26	1901	c.1817A>G	c.(1816-1818)gAg>gGg	p.E606G						ankyrin repeat domain 36C											breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TATTGGTCCCTCCTTTATTTC	0.363000													6	175					0	0	1	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:39183145A>G	ENST00000361883.5	-	1	309	c.263T>C	c.(262-264)aTc>aCc	p.I88T		NM_031957.1	NP_114163.1	Q9BYS1	KRA15_HUMAN	keratin associated protein 1-5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament		p.I88T(11)		central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	17		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632000													19	280					0	0	1	0	0
DTNB	1838	broad.mit.edu	37	2	25656844	25656844	+	Silent	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr2:25656844C>T	ENST00000406818.3	-	13	1527	c.1278G>A	c.(1276-1278)ttG>ttA	p.L426L	DTNB_ENST00000407038.3_Silent_p.L396L|DTNB_ENST00000407186.1_Silent_p.L396L|DTNB_ENST00000545439.1_Silent_p.L222L|DTNB_ENST00000496972.2_Silent_p.L369L|DTNB_ENST00000405222.1_Silent_p.L396L|DTNB_ENST00000407661.3_Silent_p.L426L|DTNB_ENST00000404103.3_Silent_p.L426L|DTNB_ENST00000288642.8_Silent_p.L426L	NM_001256303.1|NM_021907.4	NP_001243232.1|NP_068707.1	O60941	DTNB_HUMAN	dystrobrevin, beta	426	Syntrophin-binding region.					cytoplasm	calcium ion binding|zinc ion binding	p.L426F(1)		endometrium(1)|large_intestine(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTTAAAGCTCAAGTCAGTGG	0.408000													10	369					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414398	20414398	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:20414398C>G	ENST00000380338.4	-	5	732	c.446G>C	c.(445-447)aGc>aCc	p.S149T	MLLT3_ENST00000429426.2_Missense_Mutation_p.S146T|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	149	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		gctgctgctgctgGTATGAAT	0.493000			T	MLL	ALL								5	191					0	0	1	0	0
PCDHGA7	0	broad.mit.edu	37	5	140762765	140762765	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:140762765C>T	ENST00000518325.1	+	1	299	c.299C>T	c.(298-300)gCg>gTg	p.A100V	PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCAGAGTGCGCGGTGTCTG	0.483000													5	440					0	0	1	0	0
ZNF85	7639	broad.mit.edu	37	19	21132761	21132761	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:21132761C>A	ENST00000601023.1	+	2	1910	c.1264C>A	c.(1264-1266)Cct>Act	p.P422T	ZNF85_ENST00000345030.6_Missense_Mutation_p.P448T|ZNF85_ENST00000328178.8_Missense_Mutation_p.P481T			Q03923	ZNF85_HUMAN	zinc finger protein 85	481						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)	20						AGAAGAGAAACCTTACAAATG	0.358000													106	143					4.98428e-49	5.49472e-49	1	1	0
ZNF737	100129842	broad.mit.edu	37	19	20728170	20728170	+	Missense_Mutation	SNP	G	G	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:20728170G>C	ENST00000427401.4	-	4	933	c.839C>G	c.(838-840)aCt>aGt	p.T280S		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	280					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						TTTCTCTCCAGTATGAATTAT	0.413000													5	440					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145293269	145293269	+	Splice_Site	SNP	G	G	A	rs61350760	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:145293269G>A	ENST00000369338.1	+	1	155		c.e1+1		NBPF10_ENST00000369339.2_Intron|RP11-458D21.5_ENST00000468030.1_Splice_Site			A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10											NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTTCACAACAGTAAGTTAAGA	0.423000													14	224					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49427983	49427983	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:49427983C>T	ENST00000301067.7	-	38	10606	c.10607G>A	c.(10606-10608)cGc>cAc	p.R3536H		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CCGGGACTTGCGGTGTACACC	0.557000													7	953					0	0	1	0	0
GPR180	160897	broad.mit.edu	37	13	95264579	95264579	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr13:95264579A>G	ENST00000376958.4	+	3	465	c.440A>G	c.(439-441)gAa>gGa	p.E147G		NM_180989.5	NP_851320.1	Q86V85	GP180_HUMAN	G protein-coupled receptor 180	147						integral to membrane				breast(1)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	10	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					ATCCCATTTGAAATGGTGTTA	0.393000													11	550					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr16:90161902A>G	ENST00000564451.1	+	0	1255				TUBB8P7_ENST00000567960.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													17	15					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133353241	133353241	+	Silent	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:133353241T>C	ENST00000204726.3	-	21	4515	c.3957A>G	c.(3955-3957)gaA>gaG	p.E1319E	GOLGA3_ENST00000450791.2_Silent_p.E1319E|GOLGA3_ENST00000456883.2_Silent_p.E1319E	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	1319	Gln-rich.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCTGTAGCCCTTCCAGTTCCT	0.587000													6	545					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39876859	39876859	+	Silent	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:39876859C>T	ENST00000373186.4	-	9	1259	c.1122G>A	c.(1120-1122)caG>caA	p.Q374Q	MOCS1_ENST00000373188.2_Silent_p.Q374Q|MOCS1_ENST00000373175.4_Silent_p.Q345Q|MOCS1_ENST00000373195.3_Intron|MOCS1_ENST00000432280.2_Silent_p.Q345Q|MOCS1_ENST00000308559.7_Intron|MOCS1_ENST00000425303.2_Silent_p.Q374Q|MOCS1_ENST00000340692.5_Silent_p.Q374Q	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	374	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					GGTTCTTCATCTGGGAAATAC	0.592000													64	109					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53644386	53644386	+	Silent	SNP	T	T	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:53644386T>A	ENST00000452676.2	-	5	2124	c.1698A>T	c.(1696-1698)ggA>ggT	p.G566G	ZNF347_ENST00000601469.2_Silent_p.G566G|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000334197.7_Silent_p.G565G	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		AAGGTTTTTCTCCAGTATGGA	0.408000													9	1042					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803621	142803621	+	RNA	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:142803621T>C	ENST00000423385.1	-	0	1344																											TGGAAGAaactaatatctgtt	0.303000													7	228					0	0	1	0	0
ZNF57	126295	broad.mit.edu	37	19	2917842	2917842	+	Missense_Mutation	SNP	G	G	A	rs149690257	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:2917842G>A	ENST00000306908.5	+	4	1371	c.1223G>A	c.(1222-1224)cGa>cAa	p.R408Q	ZNF57_ENST00000523428.1_Missense_Mutation_p.R376Q|AC006277.2_ENST00000520090.2_RNA	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		AGATCATTCCGAGGTCATTTG	0.428000													6	756					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133353221	133353221	+	Splice_Site	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:133353221T>C	ENST00000204726.3	-	21	4535	c.3978_splice	c.e21+1	p.Q1326_splice	GOLGA3_ENST00000450791.2_Splice_Site_p.Q1326_splice|GOLGA3_ENST00000456883.2_Splice_Site_p.Q1326_splice	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	1326	Gln-rich.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CACAGGTACCTGCAGCAGCTG	0.607000													7	462					0	0	1	0	0
C19orf60	55049	broad.mit.edu	37	19	18702974	18702974	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:18702974C>T	ENST00000358607.6	+	5	667	c.590C>T	c.(589-591)gCg>gTg	p.A197V	C19orf60_ENST00000450195.2_Missense_Mutation_p.A175V|CRLF1_ENST00000594325.1_Intron	NM_001100418.1|NM_001100419.1	NP_001093888.1|NP_001093889.1	Q96EN9	CS060_HUMAN	chromosome 19 open reading frame 60	197							protein binding										AGGTTTGATGCGGAATCTGCC	0.587000													5	329					0	0	1	0	0
SPDYE3	441272	broad.mit.edu	37	7	99912180	99912180	+	Silent	SNP	G	G	A	rs858635		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:99912180G>A	ENST00000332397.6	+	6	1192	c.1008G>A	c.(1006-1008)ccG>ccA	p.P336P	SPDYE3_ENST00000437326.2_5'UTR	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	336								p.P336P(10)		endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						CCAGCCCCCCGCGTAGGTCCC	0.577000													6	352					0	0	1	0	0
PPP4C	5531	broad.mit.edu	37	16	30096070	30096070	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr16:30096070G>T	ENST00000279387.7	+	8	856	c.688G>T	c.(688-690)Gac>Tac	p.D230Y	PPP4C_ENST00000561610.1_Missense_Mutation_p.D230Y	NM_002720.1	NP_002711.1	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	230					microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|lung(2)|pancreas(1)|skin(1)|urinary_tract(1)	9						CGCAGCCAATGACATTGACAT	0.582000													9	526					0.00829132	0.00838293	1	1	0
FAM86DP	0	broad.mit.edu	37	3	75475607	75475607	+	RNA	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr3:75475607C>T	ENST00000459803.1	-	0	922					NR_024241.1																						TCACCTAGCTCGGTGGTGAAC	0.652000													3	32					0	0	1	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217340008	217340008	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr2:217340008G>A	ENST00000357276.4	+	15	2591	c.2261G>A	c.(2260-2262)cGc>cAc	p.R754H	SMARCAL1_ENST00000358207.5_Missense_Mutation_p.R754H	NM_014140.3	NP_054859.2	Q9NZC9	SMAL1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	754	Helicase C-terminal.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(15)|ovary(3)|prostate(1)|skin(1)	42		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CAGCACATCCGCATCGATGGC	0.632000									Schimke Immuno-Osseous Dysplasia				87	177					0	0	1	0	0
COASY	80347	broad.mit.edu	37	17	40714771	40714771	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:40714771G>A	ENST00000393818.2	+	1	587	c.131G>A	c.(130-132)gGc>gAc	p.G44D	COASY_ENST00000590958.1_Missense_Mutation_p.G73D|COASY_ENST00000421097.2_Missense_Mutation_p.G44D|COASY_ENST00000420359.1_Missense_Mutation_p.G44D|COASY_ENST00000449624.1_Intron	NM_025233.6	NP_079509.5	Q13057	COASY_HUMAN	CoA synthase	44					coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)	21		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		CTGCAGCCGGGCATGAGCCTG	0.662000													7	599					0	0	1	0	0
ZNF714	148206	broad.mit.edu	37	19	21281113	21281113	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:21281113C>G	ENST00000596143.1	+	3	364	c.39C>G	c.(37-39)ttC>ttG	p.F13L	ZNF714_ENST00000601416.1_Missense_Mutation_p.F13L|ZNF714_ENST00000596053.1_Missense_Mutation_p.F13L|ZNF714_ENST00000291770.7_Missense_Mutation_p.F13L	NM_182515.3	NP_872321.2	Q96N38	ZN714_HUMAN	zinc finger protein 714	13	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|urinary_tract(2)	18						ACCTGGTCTTCTTGGGTGAGA	0.338000													90	516					0	0	1	0	0
PAPL	0	broad.mit.edu	37	19	39597715	39597715	+	Silent	SNP	G	G	A	rs151134063		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:39597715G>A	ENST00000331256.5	+	12	1516	c.1242G>A	c.(1240-1242)tcG>tcA	p.S414S	PAPL_ENST00000594229.1_Intron	NM_001004318.2	NP_001004318.2	Q6ZNF0	PAPL_HUMAN		414						extracellular region	acid phosphatase activity|metal ion binding										AGCAGGTGTCGGACGACCAGG	0.622000													74	178					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								6	165					0	0	1	0	0
ANKS6	203286	broad.mit.edu	37	9	101518807	101518807	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:101518807G>A	ENST00000353234.4	-	12	2268	c.2221C>T	c.(2221-2223)Ccc>Tcc	p.P741S	ANKS6_ENST00000540940.1_Missense_Mutation_p.P546S|ANKS6_ENST00000375018.1_Missense_Mutation_p.P742S|ANKS6_ENST00000375019.2_Missense_Mutation_p.P440S			Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain containing 6	741	Ser-rich.									endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	21		Acute lymphoblastic leukemia(62;0.0527)				TTGGGTGAGGGGGAGGGCGTG	0.562000													5	381					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211517	78211517	+	RNA	SNP	C	C	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:78211517C>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TTGCTCAGGACACTCAAGGCC	0.557000													5	480					0	0	1	0	0
RASA1	5921	broad.mit.edu	37	5	86674214	86674214	+	Splice_Site	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:86674214T>C	ENST00000456692.2	+	18	1930	c.1813_splice	c.e18-1	p.D605_splice	RASA1_ENST00000274376.6_Splice_Site_p.D782_splice|RASA1_ENST00000506290.1_Splice_Site_p.D616_splice|RASA1_ENST00000512763.1_Splice_Site_p.D615_splice	NM_022650.2	NP_072179.1	P20936	RASA1_HUMAN	RAS p21 protein activator (GTPase activating protein) 1	782	C2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			NS(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(12)|lung(13)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	48		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TTTGTGTAGATGAAGCCACTA	0.373000													200	144					0	0	1	0	0
HMGCR	3156	broad.mit.edu	37	5	74652258	74652258	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:74652258G>T	ENST00000287936.4	+	15	2127	c.1971G>T	c.(1969-1971)atG>atT	p.M657I	HMGCR_ENST00000511206.1_Missense_Mutation_p.M657I|HMGCR_ENST00000343975.5_Missense_Mutation_p.M604I	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	657	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	CCATGGGGATGAACATGATTT	0.358000													128	287					4.74804e-72	5.33062e-72	1	1	0
VCAN	1462	broad.mit.edu	37	5	82815406	82815406	+	Silent	SNP	T	T	C	rs144399722	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:82815406T>C	ENST00000265077.3	+	7	1846	c.1281T>C	c.(1279-1281)acT>acC	p.T427T	VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Silent_p.T379T|VCAN_ENST00000342785.4_Silent_p.T427T|VCAN_ENST00000343200.5_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	427	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCACACCTACTGGCAGTACCA	0.463000													99	263					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:29628245G>A	ENST00000278882.3	+	6	627	c.247G>A	c.(247-249)Gcc>Acc	p.A83T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A83T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A88T														p.A83T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTTTGTTGGCCTCAAATAG	0.353000													15	802					0	0	1	0	0
PAPOLB	56903	broad.mit.edu	37	7	4900316	4900316	+	Missense_Mutation	SNP	T	T	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:4900316T>A	ENST00000404991.1	-	1	1309	c.1123A>T	c.(1123-1125)Att>Ttt	p.I375F	RADIL_ENST00000399583.3_Intron|RADIL_ENST00000536091.1_Intron	NM_020144.4	NP_064529.4	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	375					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			kidney(1)|large_intestine(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	14		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		AGAAGTACAATATAATGCTTG	0.423000													8	851					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625956	29625956	+	Missense_Mutation	SNP	G	G	A	rs147809085		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:29625956G>A	ENST00000278882.3	+	5	580	c.200G>A	c.(199-201)aGa>aAa	p.R67K	FRG1B_ENST00000358464.4_Missense_Mutation_p.R67K|FRG1B_ENST00000439954.2_Missense_Mutation_p.R72K														p.R67K(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATTGGACCAAGAGAACAATGG	0.338000													8	634					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52643597	52643597	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:52643597G>A	ENST00000399231.3	-	28	3946	c.3703C>T	c.(3703-3705)Cca>Tca	p.P1235S	MYO5A_ENST00000553916.1_Missense_Mutation_p.P1235S|MYO5A_ENST00000399233.2_Missense_Mutation_p.P1235S|MYO5A_ENST00000356338.6_Missense_Mutation_p.P1235S|MYO5A_ENST00000358212.6_Missense_Mutation_p.P1235S	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	1235					actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GTCACCTCTGGGGCACTTTTC	0.507000													142	283					0	0	1	0	0
RILPL1	353116	broad.mit.edu	37	12	123983260	123983260	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:123983260C>T	ENST00000376874.4	-	4	867	c.632G>A	c.(631-633)cGg>cAg	p.R211Q	RILPL1_ENST00000340724.6_Missense_Mutation_p.R59Q	NM_178314.3	NP_847884.2	Q5EBL4	RIPL1_HUMAN	Rab interacting lysosomal protein-like 1	211					neuroprotection	cytosol				endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.00067)|all cancers(50;0.00836)|BRCA - Breast invasive adenocarcinoma(302;0.197)		CACCGTGACCCGGTGCCGAAG	0.602000													71	747					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64519024	64519024	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr14:64519024C>T	ENST00000358025.3	+	48	8623	c.8393C>T	c.(8392-8394)aCc>aTc	p.T2798I	SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Missense_Mutation_p.T2798I|SYNE2_ENST00000554584.1_Missense_Mutation_p.T2831I	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2798					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGCCTTACAACCTATGAGGGC	0.398000													257	301					0	0	1	0	0
ZNF273	10793	broad.mit.edu	37	7	64388822	64388822	+	Silent	SNP	A	A	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:64388822A>G	ENST00000476120.1	+	4	1187	c.1116A>G	c.(1114-1116)aaA>aaG	p.K372K	ZNF273_ENST00000527278.1_3'UTR|ZNF273_ENST00000319636.5_Silent_p.K307K	NM_021148.2	NP_066971.2	Q14593	ZN273_HUMAN	zinc finger protein 273	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K372K(2)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Lung NSC(55;0.0295)|all_lung(88;0.0691)				CTGGAGAGAAACCCTACAAAT	0.383000													7	669					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724313	49724313	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:49724313G>T	ENST00000551245.1	+	13	1796	c.1685G>T	c.(1684-1686)aGt>aTt	p.S562I	TROAP_ENST00000257909.3_Missense_Mutation_p.S562I|TROAP_ENST00000547923.1_Missense_Mutation_p.S270I			Q12815	TROAP_HUMAN	trophinin associated protein	562	4 X 33 AA approximate tandem repeats.|Cys-rich.				cell adhesion	cytoplasm		p.S562I(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						TGCTGTAGGAGTGAGCCTGAG	0.592000													7	424					2.0095e-06	2.10136e-06	1	1	0
SIGLEC15	284266	broad.mit.edu	37	18	43417042	43417042	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr18:43417042C>T	ENST00000389474.3	+	2	318	c.101C>T	c.(100-102)aCa>aTa	p.T34I	SIGLEC15_ENST00000602118.2_3'UTR|SIGLEC15_ENST00000546268.1_5'UTR	NM_213602.2	NP_998767.1	Q6ZMC9	SIG15_HUMAN	sialic acid binding Ig-like lectin 15	34						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4						ttgctcaacacagaggtgcac	0.438000													170	244					0	0	1	0	0
ZNF429	353088	broad.mit.edu	37	19	21720411	21720411	+	Missense_Mutation	SNP	T	T	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:21720411T>A	ENST00000358491.4	+	4	1764	c.1556T>A	c.(1555-1557)aTc>aAc	p.I519N	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	519					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						AAAGCTTTTATCCTGTCCTCA	0.378000													6	564					0	0	1	0	0
LINC00264	0	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													5	171					0	0	1	0	0
SRSF6	6431	broad.mit.edu	37	20	42088842	42088842	+	Missense_Mutation	SNP	G	G	A	rs147863077	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:42088842G>A	ENST00000244020.3	+	4	657	c.551G>A	c.(550-552)cGc>cAc	p.R184H		NM_006275.5	NP_006266.2	Q13247	SRSF6_HUMAN	serine/arginine-rich splicing factor 6	184	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|upper_aerodigestive_tract(2)	5						GATAAGCCACGCACAAGCCAT	0.418000													64	230					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807517	20807517	+	Missense_Mutation	SNP	A	A	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:20807517A>C	ENST00000601440.1	-	4	1312	c.1166T>G	c.(1165-1167)aTa>aGa	p.I389R	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						AGTATGAATTATCTTATGCGT	0.383000													7	725					0	0	1	0	0
MSR1	0	broad.mit.edu	37	8	15967636	15967636	+	Silent	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr8:15967636G>A	ENST00000350896.3	-	9	1322	c.1125C>T	c.(1123-1125)gcC>gcT	p.A375A	MSR1_ENST00000262101.5_Silent_p.A438A|MSR1_ENST00000445506.2_Silent_p.A456A|MSR1_ENST00000355282.2_Silent_p.A375A	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	438	SRCR.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		AATGTGAACAGGCTCTTGTCC	0.368000													5	361					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12853441	12853441	+	Missense_Mutation	SNP	C	C	A	rs75270454	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:12853441C>A	ENST00000332296.7	+	2	168	c.65C>A	c.(64-66)gCc>gAc	p.A22D		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	22								p.A22D(2)		cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGAGACCAGGCCTTGTCCATC	0.562000													7	564					1.16021e-09	1.24893e-09	1	1	0
BPIFB4	149954	broad.mit.edu	37	20	31685516	31685516	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:31685516G>A	ENST00000375483.3	+	11	1492	c.1492G>A	c.(1492-1494)Gtg>Atg	p.V498M		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	498						cytoplasm|extracellular region	lipid binding										CAAAGCGCTGGTGAAGGTGTT	0.572000													129	391					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21606468	21606468	+	Missense_Mutation	SNP	C	C	T	rs142651314	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:21606468C>T	ENST00000392288.2	+	4	1116	c.1007C>T	c.(1006-1008)cCt>cTt	p.P336L	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Missense_Mutation_p.P208L	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						TTCTCAACCCCTACTAAACAT	0.348000													8	601					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628270	29628270	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:29628270G>A	ENST00000278882.3	+	6	652	c.272G>A	c.(271-273)tGc>tAc	p.C91Y	FRG1B_ENST00000358464.4_Missense_Mutation_p.C91Y|FRG1B_ENST00000439954.2_Missense_Mutation_p.C96Y																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TTTATTAGATGCAATGAAGCA	0.363000													6	743					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L|UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000584398.1_Intron														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													13	414					1.33834e-09	1.43226e-09	1	1	0
LDB3	11155	broad.mit.edu	37	10	88459097	88459097	+	Missense_Mutation	SNP	G	G	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr10:88459097G>C	ENST00000372056.4	+	8	1186	c.1163G>C	c.(1162-1164)gGc>gCc	p.G388A	LDB3_ENST00000429277.2_Intron|LDB3_ENST00000372066.3_Missense_Mutation_p.G273A|LDB3_ENST00000361373.4_Intron|LDB3_ENST00000542786.1_3'UTR|LDB3_ENST00000352360.5_Intron|LDB3_ENST00000310944.6_Missense_Mutation_p.G320A|LDB3_ENST00000263066.6_Intron|LDB3_ENST00000458213.2_Intron	NM_001171611.1	NP_001165082.1	O75112	LDB3_HUMAN	LIM domain binding 3	0						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|soft_tissue(1)	25						TGGCACCATGGCCTTTCAGCC	0.522000													372	59					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211648	78211648	+	RNA	SNP	A	A	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:78211648A>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CGCCAGGGATAGGGGCTCAGC	0.522000													4	184					0	0	1	0	0
KLF12	11278	broad.mit.edu	37	13	74387392	74387392	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr13:74387392G>T	ENST00000377669.2	-	4	729	c.703C>A	c.(703-705)Caa>Aaa	p.Q235K	KLF12_ENST00000377666.4_Missense_Mutation_p.Q235K|KLF12_ENST00000472022.1_5'UTR	NM_007249.4	NP_009180.3	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	235					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		CTTTTACTTTGTCTGGGAGAT	0.443000													261	361					4.44338e-121	5.08212e-121	1	1	0
TRBV7-7	0	broad.mit.edu	37	7	142119945	142119945	+	RNA	SNP	T	T	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:142119945T>C	ENST00000390377.1	-	0	221																											CTGATTTGTCTGGTTGAGCTT	0.532000													225	284					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810767	7810767	+	Missense_Mutation	SNP	G	G	A	rs146082308		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:7810767G>A	ENST00000315599.7	-	4	407	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	CD209_ENST00000354397.6_Missense_Mutation_p.R129W|CD209_ENST00000394161.5_Intron|CD209_ENST00000602261.1_Missense_Mutation_p.R129W|CD209_ENST00000601951.1_Missense_Mutation_p.R105W|CD209_ENST00000394173.4_Intron|CD209_ENST00000315591.8_Missense_Mutation_p.R105W|CD209_ENST00000601256.1_Missense_Mutation_p.R105W|CD209_ENST00000301357.8_Missense_Mutation_p.R85W|CD209_ENST00000204801.8_Missense_Mutation_p.R85W|CD209_ENST00000593821.1_Missense_Mutation_p.R85W|CD209_ENST00000593660.1_Missense_Mutation_p.R105W	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	129	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding	p.R129W(4)		endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GCCTTCAGCCGGGTCAGCTCC	0.567000													7	1507					0	0	1	0	0
TRIM47	91107	broad.mit.edu	37	17	73870863	73870863	+	Missense_Mutation	SNP	G	G	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:73870863G>C	ENST00000254816.2	-	6	1644	c.1618C>G	c.(1618-1620)Ctg>Gtg	p.L540V	TRIM47_ENST00000587339.1_Missense_Mutation_p.L302V	NM_033452.2	NP_258411.2	Q96LD4	TRI47_HUMAN	tripartite motif containing 47	540	B30.2/SPRY.					cytoplasm|nucleus	zinc ion binding			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	22			Epithelial(20;4.23e-06)|all cancers(21;5.24e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGGTGGGGCAGGGGAGCCTCC	0.667000													209	143					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000377425.4_Intron|AQP7_ENST00000537089.1_3'UTR|AQP7_ENST00000539936.1_3'UTR			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													12	423					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													7	251					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108236153	108236153	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr11:108236153G>T	ENST00000278616.4	+	63	9474	c.9089G>T	c.(9088-9090)gGa>gTa	p.G3030V	C11orf65_ENST00000525729.1_Intron|C11orf65_ENST00000526725.1_Intron|ATM_ENST00000452508.2_Missense_Mutation_p.G3030V|ATM_ENST00000525178.1_3'UTR	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	3030	FATC.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGTGTTGGTGGACAAGTGAAT	0.433000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			88	126					3.33908e-46	3.63721e-46	1	1	0
KCNA6	3742	broad.mit.edu	37	12	4919415	4919415	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:4919415C>T	ENST00000433855.1	+	1	1074	c.208C>T	c.(208-210)Cct>Tct	p.P70S	KCNA6_ENST00000280684.3_Missense_Mutation_p.P70S	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	70						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						GCTCGGAGACCCTGGCCGGCG	0.607000										HNSCC(72;0.22)			204	154					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39799857	39799857	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:39799857G>A	ENST00000564288.1	+	37	8374	c.7597G>A	c.(7597-7599)Gag>Aag	p.E2533K	MACF1_ENST00000372915.3_Missense_Mutation_p.E2538K|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000567887.1_Missense_Mutation_p.E2570K|MACF1_ENST00000289893.4_Missense_Mutation_p.E973K|MACF1_ENST00000539005.1_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2538					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGATTTAGCCGAGAAACTCAA	0.358000													115	201					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8716284	8716285	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:8716284_8716285delTC	ENST00000337907.3	-	3	706_707	c.72_73delGA	c.(70-75)gaaafs	p.EK24fs	RERE_ENST00000400908.2_Frame_Shift_Del_p.EK24fs|RERE_ENST00000400907.2_Frame_Shift_Del_p.EK24fs	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	24					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TTGTCTCTTTTCtctctctctc	0.505													10	653	---	---	---	---					
AADACL3	126767	broad.mit.edu	37	1	12785492	12785493	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:12785492_12785493insT	ENST00000332530.3	+	3	598_599	c.372_373insT	c.(370-375)tagtttfs	p.*F124fs	AADACL3_ENST00000359318.5_Frame_Shift_Ins_p.*F194fs	NM_001103169.1	NP_001096639.1	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3	194							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TCATCTGCTACTGTTTTTTTCA	0.455													9	694	---	---	---	---					
SRSF4	6429	broad.mit.edu	37	1	29475219	29475221	+	In_Frame_Del	DEL	CTT	CTT	-	rs138237342	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:29475219_29475221delCTT	ENST00000373795.4	-	6	1420_1422	c.1186_1188delAAG	c.(1186-1188)del	p.K396del	SRSF4_ENST00000546138.1_3'UTR|SRSF4_ENST00000466448.1_5'UTR	NM_005626.4	NP_005617.2	Q08170	SRSF4_HUMAN	serine/arginine-rich splicing factor 4	396	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(1)	27						CAGTGTCTTCCTTCTTCTTCTTC	0.601													7	526	---	---	---	---					
ZMYM4	9202	broad.mit.edu	37	1	35846959	35846960	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:35846959_35846960insA	ENST00000314607.6	+	8	1361_1362	c.1281_1282insA	c.(1279-1284)ctaaaafs	p.LK427fs	ZMYM4_ENST00000373297.2_Frame_Shift_Ins_p.LK427fs	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	427					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CATATGAACTGAAAAAAAAACC	0.342													7	327	---	---	---	---					
TMCO2	127391	broad.mit.edu	37	1	40713708	40713709	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:40713708_40713709delTC	ENST00000372766.3	+	1	136_137	c.43_44delTC	c.(43-45)tfs	p.S15fs	TMCO2_ENST00000468258.1_Intron	NM_001008740.3	NP_001008740.1	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2	15						integral to membrane				kidney(1)|large_intestine(3)|lung(1)|ovary(1)	6	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			CCTCTTAGAGTCTCTCTCTCTC	0.406													7	744	---	---	---	---					
SLC6A9	6536	broad.mit.edu	37	1	44489938	44489938	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:44489938delT	ENST00000372310.3	-	2	177	c.12delA	c.(10-12)aafs	p.K4fs	SLC6A9_ENST00000475075.2_5'UTR|SLC6A9_ENST00000492434.2_5'UTR|SLC6A9_ENST00000372306.3_Frame_Shift_Del_p.K4fs|SLC6A9_ENST00000537678.1_5'UTR	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	335						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	CTTTGGCACCTTTTCCTACCA	0.627													7	1200	---	---	---	---					
CYP4Z2P	0	broad.mit.edu	37	1	47310359	47310360	+	RNA	INS	-	-	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:47310359_47310360insT	ENST00000505841.1	-	0	1269					NR_002788.2																						CAAAAACAAAACCCTAGATATT	0.421													9	51	---	---	---	---					
BCL10	8915	broad.mit.edu	37	1	85736511	85736511	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:85736511delT	ENST00000370580.1	-	2	873	c.136delA	c.(136-138)tafs	p.I46fs		NM_003921.4	NP_003912.1	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	46	CARD.				apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding	p.I46fs*4(1)		haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	19				all cancers(265;0.0114)|Epithelial(280;0.0311)		CTACTGAGTATTTTTTTTGCA	0.343			T	IGH@	MALT								9	427	---	---	---	---					
SYCP1	6847	broad.mit.edu	37	1	115537600	115537601	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:115537600_115537601insA	ENST00000369522.3	+	32	3131_3132	c.2891_2892insA	c.(2890-2892)aaafs	p.K964fs	SYCP1_ENST00000477590.1_3'UTR|SYCP1_ENST00000369518.1_Frame_Shift_Ins_p.K964fs	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	964	Arg/Lys-rich (basic).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAATGGATAGAAAAAAAAAAC	0.356													21	252	---	---	---	---					
PRRC2C	23215	broad.mit.edu	37	1	171511148	171511149	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr1:171511148_171511149insA	ENST00000367742.3	+	16	4785_4786	c.4543_4544insA	c.(4543-4545)aaafs	p.K1515fs	PRRC2C_ENST00000338920.4_Frame_Shift_Ins_p.K1513fs|PRRC2C_ENST00000392078.3_Frame_Shift_Ins_p.K1515fs|PRRC2C_ENST00000426496.2_Frame_Shift_Ins_p.K1513fs			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	1513							protein C-terminus binding										AGAGAGGGATGAAAAAAAAAAT	0.391													11	231	---	---	---	---					
AC016995.3	0	broad.mit.edu	37	2	38710019	38710019	+	RNA	DEL	T	T	-	rs2005502	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr2:38710019delT	ENST00000417039.1	-	0	696																											CTTtaaaaaataaataaataa	0.244													4	3	---	---	---	---					
AC105399.2	0	broad.mit.edu	37	2	78020197	78020199	+	RNA	DEL	TCC	TCC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr2:78020197_78020199delTCC	ENST00000422418.1	+	0	402_404																											ATACTAAAAATCCTaaaaaaaaa	0.320													7	25	---	---	---	---					
CH17-132F21.1	0	broad.mit.edu	37	2	90458648	90458648	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr2:90458648delT	ENST00000603238.1	+	2	324	c.324delT	c.(322-324)tgfs	p.108fs																								CTTATTACTGTCAACAGAGTG	0.512													8	2864	---	---	---	---					
GIGYF2	26058	broad.mit.edu	37	2	233712228	233712230	+	In_Frame_Del	DEL	CAG	CAG	-	rs72096937		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr2:233712228_233712230delCAG	ENST00000373566.3	+	28	3894_3896	c.3697_3699delCAG	c.(3697-3699)del	p.Q1238del	GIGYF2_ENST00000409547.1_In_Frame_Del_p.Q1216del|GIGYF2_ENST00000409196.3_In_Frame_Del_p.Q1210del|GIGYF2_ENST00000373563.4_In_Frame_Del_p.Q1216del|GIGYF2_ENST00000409451.3_In_Frame_Del_p.Q1237del|GIGYF2_ENST00000409480.1_In_Frame_Del_p.Q1238del			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	1216	Gln-rich.				cell death		protein binding	p.Q1216delQ(2)|p.Q1237delQ(1)		NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		gcagctgccacagcagcagcagc	0.547													8	196	---	---	---	---					
GAL3ST2	64090	broad.mit.edu	37	2	242738494	242738496	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr2:242738494_242738496delTCC	ENST00000192314.6	+	2	175_177	c.44_46delTCC	c.(43-48)atc>a	p.IL15del		NM_022134.2	NP_071417.2	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	15					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity	p.L16I(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TTCCGGGTCATCCTCCTCCTCCT	0.631													13	306	---	---	---	---					
AC034193.5	0	broad.mit.edu	37	3	10035779	10035783	+	RNA	DEL	AGTCT	AGTCT	-	rs35714562		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr3:10035779_10035783delAGTCT	ENST00000326237.3	+	0	354																											GGGGAAGAGAAGTCTGATCTGACAT	0.380													11	126	---	---	---	---					
NKTR	4820	broad.mit.edu	37	3	42680269	42680271	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr3:42680269_42680271delGAG	ENST00000232978.8	+	13	3261_3263	c.3073_3075delGAG	c.(3073-3075)del	p.E1029del	RP4-613B23.1_ENST00000445452.1_RNA|RP4-613B23.1_ENST00000438017.1_RNA|RP4-613B23.1_ENST00000434363.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1029					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		ATTTGGTGAAGAGGAGGAGGAGG	0.355													8	350	---	---	---	---					
CCKAR	886	broad.mit.edu	37	4	26483672	26483674	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:26483672_26483674delCTG	ENST00000295589.3	-	5	1067_1069	c.873_875delCAG	c.(871-876)agg>ag	p.SR291del		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	291					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	GCGGTTGGCCCTGCTGCTGCTGC	0.606													8	776	---	---	---	---					
UBE2K	3093	broad.mit.edu	37	4	39779392	39779392	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:39779392delA	ENST00000261427.5	+	6	774	c.490delA	c.(490-492)aafs	p.K165fs	UBE2K_ENST00000295963.6_Frame_Shift_Del_p.K104fs|UBE2K_ENST00000503368.1_Frame_Shift_Del_p.K114fs|UBE2K_ENST00000438068.2_3'UTR|UBE2K_ENST00000445950.2_Intron	NM_001111112.1|NM_005339.4	NP_001104582.1|NP_005330.1	P61086	UBE2K_HUMAN	ubiquitin-conjugating enzyme E2K	165	UBA.				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|ubiquitin protein ligase binding|ubiquitin-ubiquitin ligase activity			large_intestine(1)|lung(1)|ovary(2)	4						AGAATACACCAAAAAAATAGA	0.363													8	951	---	---	---	---					
GABRG1	2565	broad.mit.edu	37	4	46060358	46060358	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:46060358delA	ENST00000295452.4	-	7	959	c.792delT	c.(790-792)ttfs	p.F264fs		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	264					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity	p.F264fs*3(1)		breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TGCTCAGGTCAAAAAAAATTG	0.294													13	439	---	---	---	---					
CLOCK	9575	broad.mit.edu	37	4	56304530	56304532	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:56304530_56304532delCTG	ENST00000309964.4	-	21	2528_2530	c.2278_2280delCAG	c.(2278-2280)del	p.Q760del	CLOCK_ENST00000513440.1_In_Frame_Del_p.Q760del|CLOCK_ENST00000381322.1_In_Frame_Del_p.Q760del	NM_004898.3	NP_004889.1	O15516	CLOCK_HUMAN	clock circadian regulator	760	Gln-rich.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(8)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			cctgggagctctgctgctgctgc	0.512													10	344	---	---	---	---					
C4orf22	255119	broad.mit.edu	37	4	81791254	81791254	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:81791254delA	ENST00000358105.3	+	4	490	c.441delA	c.(439-441)ggfs	p.G147fs	C4orf22_ENST00000508675.1_Frame_Shift_Del_p.G164fs	NM_152770.2	NP_689983.2	Q6V702	CD022_HUMAN	chromosome 4 open reading frame 22	147										NS(1)|large_intestine(3)|lung(5)|prostate(1)|skin(5)	15						ACTTTACTGGAAAAAAAAGAC	0.373													10	732	---	---	---	---					
WDFY3	23001	broad.mit.edu	37	4	85611708	85611709	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:85611708_85611709delCA	ENST00000322366.6	-	60	9669_9670	c.9262_9263delTG	c.(9262-9264)gfs	p.W3088fs	WDFY3_ENST00000295888.4_Frame_Shift_Del_p.W3105fs			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	3105						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GCCCATCTCCCACACACACACA	0.510													7	481	---	---	---	---					
NAP1L5	266812	broad.mit.edu	37	4	89618431	89618433	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:89618431_89618433delCCT	ENST00000323061.5	-	1	953_955	c.473_475delAGG	c.(472-477)gct>g	p.EA158del	HERC3_ENST00000264345.3_Intron|HERC3_ENST00000543130.1_Intron|HERC3_ENST00000402738.1_Intron	NM_153757.2	NP_715638.1	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	158	Glu-rich.				nucleosome assembly	nucleus	protein binding			endometrium(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		TCTGCCGCAGcctcctcctcctc	0.626													8	772	---	---	---	---					
NPNT	255743	broad.mit.edu	37	4	106863682	106863684	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:106863682_106863684delCCA	ENST00000379987.2	+	8	1198_1200	c.982_984delCCA	c.(982-984)del	p.P333del	NPNT_ENST00000305572.8_In_Frame_Del_p.P333del|NPNT_ENST00000506666.1_In_Frame_Del_p.P363del|NPNT_ENST00000453617.2_In_Frame_Del_p.P350del|NPNT_ENST00000514622.1_In_Frame_Del_p.P333del|NPNT_ENST00000427316.2_In_Frame_Del_p.P363del	NM_001033047.2	NP_001028219.1	Q6UXI9	NPNT_HUMAN	nephronectin	333	Pro-rich.				cell differentiation	membrane	calcium ion binding			kidney(5)|large_intestine(2)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	21		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		AATTCCTACTCCACCACCACCAC	0.522													8	495	---	---	---	---					
ADAD1	132612	broad.mit.edu	37	4	123302211	123302211	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:123302211delA	ENST00000296513.2	+	4	422	c.237delA	c.(235-237)ccfs	p.P79fs	ADAD1_ENST00000388725.2_Frame_Shift_Del_p.P61fs|ADAD1_ENST00000492454.1_3'UTR|ADAD1_ENST00000388724.2_Frame_Shift_Del_p.P79fs	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	79					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						TCCTTCCTCCAAAAAAAATAC	0.358													9	613	---	---	---	---					
LARP1B	55132	broad.mit.edu	37	4	129127627	129127627	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:129127627delA	ENST00000326639.6	+	18	2565	c.2354delA	c.(2353-2355)gafs	p.E785fs	LARP1B_ENST00000506199.1_3'UTR|LARP1B_ENST00000354456.3_Frame_Shift_Del_p.E204fs|LARP1B_ENST00000441387.1_Intron|LARP1B_ENST00000264584.5_Frame_Shift_Del_p.E726fs	NM_018078.2	NP_060548.2	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family, member 1B	785							RNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(11)|ovary(1)|prostate(3)	34						TATGGACTGGAAAAAAAATTC	0.289													11	753	---	---	---	---					
OTUD4	54726	broad.mit.edu	37	4	146077123	146077125	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:146077123_146077125delCAG	ENST00000454497.2	-	8	595_597	c.458_460delCTG	c.(457-462)gat>g	p.AD153del	OTUD4_ENST00000455611.2_5'UTR|OTUD4_ENST00000447906.2_In_Frame_Del_p.AD218del	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	218	OTU.						protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					CCATTCACATCAGCAGCAGCAGC	0.340													12	620	---	---	---	---					
VEGFC	7424	broad.mit.edu	37	4	177608415	177608415	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:177608415delT	ENST00000280193.2	-	6	1486	c.1071delA	c.(1069-1071)aafs	p.K357fs	RP11-313E19.2_ENST00000509194.1_RNA|RP11-313E19.2_ENST00000504017.1_RNA	NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	357	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		CACAGGCACATTTTCCAGGAT	0.428													7	1680	---	---	---	---					
FRG1	2483	broad.mit.edu	37	4	190873437	190873439	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr4:190873437_190873439delAAG	ENST00000226798.4	+	3	476_478	c.254_256delAAG	c.(253-258)aaa>a	p.KE85del	FRG1_ENST00000514482.1_3'UTR	NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	85					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		GCTCCACACAAAGAAGGTTTGTG	0.414													9	940	---	---	---	---					
TRIM23	373	broad.mit.edu	37	5	64910015	64910016	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:64910015_64910016insT	ENST00000231524.9	-	3	646_647	c.275_276insA	c.(274-276)attfs	p.I92fs	TRIM23_ENST00000381018.3_Frame_Shift_Ins_p.I92fs|TRIM23_ENST00000274327.7_Frame_Shift_Ins_p.I92fs	NM_001656.3	NP_001647.1	P36406	TRI23_HUMAN	tripartite motif containing 23	92					interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.N92I(1)|p.N92K(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	28		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		ATAAAGCAAAATTTTTTTTCAA	0.356													7	596	---	---	---	---					
MSH3	4437	broad.mit.edu	37	5	79970915	79970915	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:79970915delA	ENST00000265081.6	+	7	1221	c.1141delA	c.(1141-1143)aafs	p.K383fs		NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	383					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		TGTTAGGGACAAAAAAAAGGG	0.348								Mismatch excision repair (MMR)					7	740	---	---	---	---					
RASGRF2	5924	broad.mit.edu	37	5	80409566	80409568	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:80409566_80409568delCCA	ENST00000265080.4	+	15	2364_2366	c.2297_2299delCCA	c.(2296-2301)ccc>c	p.PT766del	CTD-2193P3.2_ENST00000508993.1_RNA	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	766					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TCCAGCAGTCCCACCACCACCAC	0.562													7	439	---	---	---	---					
SLC22A4	6583	broad.mit.edu	37	5	131676327	131676327	+	Frame_Shift_Del	DEL	T	T	-	rs72552721		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:131676327delT	ENST00000200652.3	+	9	1688	c.1514delT	c.(1513-1515)ctfs	p.L505fs	AC034220.3_ENST00000417795.1_RNA|AC034220.3_ENST00000437091.1_RNA	NM_003059.2	NP_003050.2	Q9H015	S22A4_HUMAN	solute carrier family 22 (organic cation/zwitterion transporter), member 4	505					body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity	p.E509fs*1(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|urinary_tract(1)	16		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	ATCCTCACCCTTTTTTTCCCT	0.418													9	1020	---	---	---	---					
KDM3B	51780	broad.mit.edu	37	5	137754813	137754814	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:137754813_137754814delAG	ENST00000314358.5	+	14	3807_3808	c.3607_3608delAG	c.(3607-3609)tfs	p.S1203fs	KDM3B_ENST00000508386.1_3'UTR|KDM3B_ENST00000394866.1_Frame_Shift_Del_p.S859fs|KDM3B_ENST00000542866.1_Frame_Shift_Del_p.S235fs	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	1203					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						AAATAGCAATAGTGAACTGAAA	0.520													91	216	---	---	---	---					
PCDHGB7	0	broad.mit.edu	37	5	140799824	140799826	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:140799824_140799826delAAG	ENST00000398594.2	+	1	2398_2400	c.2398_2400delAAG	c.(2398-2400)del	p.K801del	PCDHGA7_ENST00000518325.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAAGCAGATAAGAAGATTCTTA	0.305													167	160	---	---	---	---					
RNF145	153830	broad.mit.edu	37	5	158630629	158630630	+	Frame_Shift_Ins	INS	-	-	T	rs114633421	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:158630629_158630630insT	ENST00000274542.2	-	2	106_107	c.80_81insA	c.(79-81)aaafs	p.K27fs	RNF145_ENST00000519865.1_5'UTR|RNF145_ENST00000424310.2_5'UTR|RNF145_ENST00000520638.1_Frame_Shift_Ins_p.K13fs|RNF145_ENST00000518802.1_Frame_Shift_Ins_p.K29fs|RNF145_ENST00000521606.2_Frame_Shift_Ins_p.K16fs	NM_144726.2	NP_653327.1	Q96MT1	RN145_HUMAN	ring finger protein 145	0						integral to membrane	zinc ion binding	p.N27K(1)		endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGCCATGTTGttttttttttt	0.376													8	323	---	---	---	---					
GRK6	2870	broad.mit.edu	37	5	176863219	176863221	+	In_Frame_Del	DEL	GAA	GAA	-	rs76969408		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr5:176863219_176863221delGAA	ENST00000355472.5	+	12	1371_1373	c.1203_1205delGAA	c.(1201-1206)gtg>gt	p.VK401del	GRK6_ENST00000507633.1_In_Frame_Del_p.VK401del|GRK6_ENST00000355958.5_In_Frame_Del_p.VK401del|GRK6_ENST00000528793.1_In_Frame_Del_p.VK401del|GRK6_ENST00000393576.3_In_Frame_Del_p.VK367del	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	401	Protein kinase.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity	p.K402delK(1)		breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCGGCTGGTGAAGGAGGTCCCC	0.645													8	455	---	---	---	---					
BTN2A3P	0	broad.mit.edu	37	6	26422388	26422390	+	RNA	DEL	CCT	CCT	-	rs113134648		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:26422388_26422390delCCT	ENST00000466808.2	+	0	42_44																											GGCCAGCCTCCCTCCTCCTCCTC	0.586													10	466	---	---	---	---					
HLA-DRB6	0	broad.mit.edu	37	6	32522756	32522756	+	RNA	DEL	A	A	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:32522756delA	ENST00000411500.1	-	0	458					NR_001298.1																						GGACTAGGAGAAAAAAAGGTA	0.517													8	122	---	---	---	---					
KIAA1009	22832	broad.mit.edu	37	6	84896233	84896233	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:84896233delA	ENST00000403245.3	-	12	1332	c.1218delT	c.(1216-1218)ttfs	p.F406fs	KIAA1009_ENST00000461137.1_5'UTR|KIAA1009_ENST00000257766.4_Frame_Shift_Del_p.F330fs	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	406					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		CATTTTTGTCAAAAAAAAGGT	0.358													7	511	---	---	---	---					
RNGTT	8732	broad.mit.edu	37	6	89638988	89638988	+	Splice_Site	DEL	T	T	-	rs111616936		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:89638988delT	ENST00000369485.4	-	3	361		c.e3-2		RNGTT_ENST00000538899.1_Splice_Site|RNGTT_ENST00000265607.6_Splice_Site|RNGTT_ENST00000369475.3_Splice_Site	NM_003800.3	NP_003791.3	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase						interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	21		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		CATTTTAACCTAAAAAAAAAA	0.299													8	339	---	---	---	---					
GABRR2	2570	broad.mit.edu	37	6	89975427	89975429	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:89975427_89975429delAAG	ENST00000402938.3	-	7	925_927	c.792_794delCTT	c.(790-795)ttg>tt	p.FL264del	GABRR2_ENST00000602399.1_In_Frame_Del_p.FL289del			P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 2	289					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(10)|prostate(2)|urinary_tract(1)	21		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		TGTTTGGAGCAAGAAGAAGAAGA	0.517													9	265	---	---	---	---					
PHACTR2	9749	broad.mit.edu	37	6	144081695	144081696	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr6:144081695_144081696insA	ENST00000427704.2	+	5	709_710	c.579_580insA	c.(577-582)ataaaafs	p.IK193fs	PHACTR2_ENST00000367582.3_Intron|PHACTR2_ENST00000367584.4_Intron|PHACTR2_ENST00000440869.2_Frame_Shift_Ins_p.IK204fs|PHACTR2_ENST00000305766.6_Intron	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2	193							actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		TGCCTCCCATTAAAAAAAATAC	0.569													7	325	---	---	---	---					
HOXA1	3198	broad.mit.edu	37	7	27135317	27135319	+	In_Frame_Del	DEL	TGG	TGG	-	rs2074398	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:27135317_27135319delTGG	ENST00000343060.4	-	1	274_276	c.213_215delCCA	c.(211-216)cat>ca	p.HH71del	HOTAIRM1_ENST00000495032.1_RNA|HOXA1_ENST00000355633.5_In_Frame_Del_p.HH71del	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	71	Poly-His.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						ggggtggcgatggtggtggtggt	0.640											OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	357	---	---	---	---					
PPP1R17	10842	broad.mit.edu	37	7	31735179	31735179	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:31735179delA	ENST00000342032.3	+	3	807	c.179delA	c.(178-180)cafs	p.Q60fs	PPP1R17_ENST00000409146.3_Intron	NM_006658.4	NP_006649.2	O96001	GSUB_HUMAN	protein phosphatase 1, regulatory subunit 17	60					behavior|central nervous system development|intracellular protein kinase cascade|protein phosphorylation	soluble fraction											GAGTCAGACCAAAAAAAACCA	0.438													9	1096	---	---	---	---					
TRGC1	0	broad.mit.edu	37	7	38301855	38301856	+	RNA	DEL	GT	GT	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:38301855_38301856delGT	ENST00000443402.2	-	0	330					NM_001003799.1|NM_001003806.1	NP_001003799.1|NP_001003806.1																					TCAATTGTTCGTGTGTGTGTGT	0.356													12	851	---	---	---	---					
INHBA	3624	broad.mit.edu	37	7	41729741	41729743	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:41729741_41729743delTTC	ENST00000242208.4	-	3	1032_1034	c.786_788delGAA	c.(784-789)aaa>aa	p.KK262del	AC005027.3_ENST00000416150.1_RNA|INHBA_ENST00000464515.1_5'UTR|INHBA_ENST00000442711.1_In_Frame_Del_p.KK262del	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	262					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						ctcctcttctttcttcttcttct	0.581										TSP Lung(11;0.080)			10	285	---	---	---	---					
CCT6P3	0	broad.mit.edu	37	7	64528813	64528814	+	RNA	INS	-	-	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:64528813_64528814insT	ENST00000426828.1	+	0	621					NR_033416.1																						CTTTCTGTAACTTTTTTTTTTT	0.317													7	93	---	---	---	---					
STAG3L4	0	broad.mit.edu	37	7	66767610	66767611	+	RNA	INS	-	-	G	rs71293166	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:66767610_66767611insG	ENST00000416602.2	+	0	3_4					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				CACCGGACTGCTTTTTTTTTTT	0.545													7	14	---	---	---	---					
GTF2IRD2P1	0	broad.mit.edu	37	7	72683455	72683456	+	RNA	INS	-	-	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:72683455_72683456insT	ENST00000425256.1	-	0	120					NR_002164.1																						CGTTCTACCAgtttttttttgt	0.441													8	566	---	---	---	---					
STX1A	6804	broad.mit.edu	37	7	73123425	73123427	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:73123425_73123427delCAT	ENST00000222812.3	-	2	82_84	c.56_58delATG	c.(55-60)gtc>g	p.DV19del	STX1A_ENST00000395156.3_In_Frame_Del_p.DV19del|STX1A_ENST00000395154.3_In_Frame_Del_p.DV19del|STX1A_ENST00000395155.3_In_Frame_Del_p.DV19del	NM_004603.3	NP_004594.1	Q16623	STX1A_HUMAN	syntaxin 1A (brain)	19					energy reserve metabolic process|glutamate secretion|intracellular protein transport|regulation of insulin secretion	cell junction|extracellular region|integral to membrane|neuron projection|synaptic vesicle membrane|synaptosome	SNAP receptor activity			large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	5		Lung NSC(55;0.0908)|all_lung(88;0.198)				GTGACAGCGACATCATCATCATC	0.586													8	850	---	---	---	---					
AKAP9	10142	broad.mit.edu	37	7	91671392	91671393	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:91671392_91671393delAG	ENST00000359028.2	+	20	5211_5212	c.4986_4987delAG	c.(4984-4989)tcagfs	p.SE1662fs	AKAP9_ENST00000356239.3_Frame_Shift_Del_p.SE1650fs|AKAP9_ENST00000358100.2_Frame_Shift_Del_p.SE1662fs			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1662					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ACCTGGTTTCAGAGAGAGAGAG	0.411			T	BRAF	papillary thyroid								8	443	---	---	---	---					
GPC2	221914	broad.mit.edu	37	7	99771554	99771554	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:99771554delC	ENST00000292377.2	-	5	963	c.796delG	c.(796-798)tcfs	p.V266fs	GPC2_ENST00000471050.1_5'UTR	NM_152742.1	NP_689955.1	Q8N158	GPC2_HUMAN	glypican 2	266						anchored to membrane|endoplasmic reticulum|extracellular space|plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(3)	18	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGTGAGGGGACCCCCCGGCAC	0.642													7	1363	---	---	---	---					
MEPCE	56257	broad.mit.edu	37	7	100028823	100028825	+	In_Frame_Del	DEL	CCA	CCA	-	rs71555278		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:100028823_100028825delCCA	ENST00000310512.2	+	1	1570_1572	c.1182_1184delCCA	c.(1180-1185)cgc>cg	p.RH394del	MEPCE_ENST00000414441.1_5'UTR	NM_019606.5	NP_062552.2	Q7L2J0	MEPCE_HUMAN	methylphosphate capping enzyme	394							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(9)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGGGAGGCCGCCACCACCACCAC	0.581													7	455	---	---	---	---					
GIGYF1	64599	broad.mit.edu	37	7	100284335	100284337	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:100284335_100284337delCCT	ENST00000275732.5	-	7	1838_1840	c.629_631delAGG	c.(628-633)ggc>g	p.EG210del	GIGYF1_ENST00000471340.2_Intron	NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	210	Poly-Glu.							p.E210delE(1)		central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CTCCAGCTGCcctcctcctcctc	0.700													11	384	---	---	---	---					
WASL	8976	broad.mit.edu	37	7	123332839	123332841	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:123332839_123332841delAGG	ENST00000223023.4	-	9	1239_1241	c.907_909delCCT	c.(907-909)del	p.P303del		NM_003941.2	NP_003932.3	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome-like	303	Pro-rich.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity	p.P303A(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TTCCCCTagcaggaggaggagga	0.616													7	439	---	---	---	---					
OR9A4	130075	broad.mit.edu	37	7	141619203	141619203	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:141619203delT	ENST00000548136.1	+	1	587	c.528delT	c.(526-528)aafs	p.N176fs	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					TGGTGAACAATTTTTTTTGTG	0.383													8	1354	---	---	---	---					
TRBV29-1	0	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													15	40	---	---	---	---					
PRSS3P2	0	broad.mit.edu	37	7	142481996	142481997	+	RNA	INS	-	-	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:142481996_142481997insC	ENST00000603901.1	+	0	591					NR_001296.3																						TCCCAAGGTGGGGGGCTGAGGA	0.564													15	94	---	---	---	---					
EPHB6	0	broad.mit.edu	37	7	142562309	142562309	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr7:142562309delG	ENST00000392957.2	+	7	1538	c.751delG	c.(751-753)ggfs	p.G252fs	EPHB6_ENST00000411471.2_Intron|EPHB6_ENST00000442129.1_Frame_Shift_Del_p.G252fs	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	252	Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					CAGTGGGGCTGGGGGGGCCTC	0.682													7	978	---	---	---	---					
DLC1	10395	broad.mit.edu	37	8	12957611	12957613	+	In_Frame_Del	DEL	GCT	GCT	-	rs137989738		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr8:12957611_12957613delGCT	ENST00000276297.4	-	9	2642_2644	c.2233_2235delAGC	c.(2233-2235)del	p.S745del	DLC1_ENST00000358919.2_In_Frame_Del_p.S308del|DLC1_ENST00000520226.1_In_Frame_Del_p.S234del|DLC1_ENST00000512044.2_In_Frame_Del_p.S342del	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	745	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						TCTCCGACTGGCTGCTGCTGCTG	0.621													8	217	---	---	---	---					
SFTPC	6440	broad.mit.edu	37	8	22020159	22020161	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr8:22020159_22020161delGTG	ENST00000521315.1	+	2	147_149	c.115_117delGTG	c.(115-117)del	p.V44del	SFTPC_ENST00000318561.3_In_Frame_Del_p.V44del|SFTPC_ENST00000522109.1_In_Frame_Del_p.V44del|SFTPC_ENST00000520605.1_Intron|SFTPC_ENST00000437090.2_In_Frame_Del_p.V44del|SFTPC_ENST00000524255.1_Intron			P11686	PSPC_HUMAN	surfactant protein C	44					respiratory gaseous exchange	extracellular space				autonomic_ganglia(1)|large_intestine(1)|lung(1)	3				Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CCTTCTTATCGTGGTGGTGGTGG	0.601													8	444	---	---	---	---					
KAT6A	7994	broad.mit.edu	37	8	41798420	41798422	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr8:41798420_41798422delCTC	ENST00000396930.3	-	16	3520_3522	c.2977_2979delGAG	c.(2977-2979)del	p.E993del	KAT6A_ENST00000406337.1_In_Frame_Del_p.E993del|KAT6A_ENST00000265713.2_In_Frame_Del_p.E993del	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	993	Poly-Glu.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										GGCTTTCCGGCTCCTCCTCCTCC	0.567													7	605	---	---	---	---					
TAF1L	138474	broad.mit.edu	37	9	32633584	32633584	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:32633584delT	ENST00000242310.4	-	1	2083	c.1994delA	c.(1993-1995)agfs	p.K665fs	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	665					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding	p.K665fs*4(2)		breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CATCTTGGCCTTTTTTTTGAT	0.478													13	856	---	---	---	---					
KIF24	347240	broad.mit.edu	37	9	34257623	34257623	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:34257623delT	ENST00000379166.2	-	11	2101	c.1982delA	c.(1981-1983)agfs	p.K661fs	KIF24_ENST00000379174.3_Frame_Shift_Del_p.K527fs|KIF24_ENST00000402558.2_Frame_Shift_Del_p.K661fs|KIF24_ENST00000345050.2_Frame_Shift_Del_p.K527fs	NM_194313.2	NP_919289.2	Q5T7B8	KIF24_HUMAN	kinesin family member 24	661					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity	p.K143fs*34(1)|p.K661fs*34(1)		breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(13)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	32			LUSC - Lung squamous cell carcinoma(29;0.0107)			CTCTTCTGGCTTTTTTTTGGC	0.527													11	525	---	---	---	---					
RUSC2	9853	broad.mit.edu	37	9	35560102	35560104	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:35560102_35560104delGCT	ENST00000455600.1	+	10	4034_4036	c.3465_3467delGCT	c.(3463-3468)gag>ga	p.EL1155del		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1155	RUN.					cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			TCTTTGAAGAGCTGCTGCTGCTG	0.616													7	1124	---	---	---	---					
HRCT1	646962	broad.mit.edu	37	9	35906348	35906350	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:35906348_35906350delCTG	ENST00000354323.2	+	1	160_162	c.64_66delCTG	c.(64-66)del	p.L28del		NM_001039792.1	NP_001034881.1	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	28						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						TGTGGCGGTCctgctgctgctgc	0.670													13	149	---	---	---	---					
ZCCHC7	84186	broad.mit.edu	37	9	37357249	37357250	+	Frame_Shift_Ins	INS	-	-	A	rs1051465		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:37357249_37357250insA	ENST00000336755.5	+	9	1722_1723	c.1616_1617insA	c.(1615-1617)aaafs	p.K539fs	ZCCHC7_ENST00000534928.1_Frame_Shift_Ins_p.K249fs|ZCCHC7_ENST00000461038.1_3'UTR	NM_032226.2	NP_115602.2	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	539			R -> K (in dbSNP:rs1051465).				nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	30				GBM - Glioblastoma multiforme(29;0.0137)		ATTAAGCAGAGAAAAAAAAAGT	0.411													11	345	---	---	---	---					
FAM74A3	0	broad.mit.edu	37	9	40715923	40715924	+	RNA	DEL	AA	AA	-	rs62565543		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:40715923_40715924delAA	ENST00000604146.1	+	0	262_263					NR_026801.1															endometrium(1)|large_intestine(2)|lung(6)|skin(1)	10				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GAAGACGTGGAAAGAGCTCAGA	0.569													13	147	---	---	---	---					
ANKRD20A1	84210	broad.mit.edu	37	9	67934791	67934794	+	Frame_Shift_Del	DEL	AAAG	AAAG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:67934791_67934794delAAAG	ENST00000377477.2	+	4	673_676	c.561_564delAAAG	c.(559-564)aafs	p.KK187fs		NM_032250.3	NP_115626.2			ankyrin repeat domain 20 family, member A1											kidney(1)|large_intestine(4)|lung(5)|urinary_tract(1)	11						TTTTATTGAAAAAGAAAGCAAGTT	0.309													9	34	---	---	---	---					
ROR2	4920	broad.mit.edu	37	9	94486026	94486028	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:94486026_94486028delTCC	ENST00000375708.3	-	9	2946_2948	c.2748_2750delGGA	c.(2746-2751)gaa>ga	p.EE916del	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Intron	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	916					negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GACAGAGCCTTCCTCCTCCTCCT	0.645													10	787	---	---	---	---					
XPA	7507	broad.mit.edu	37	9	100455962	100455964	+	In_Frame_Del	DEL	TTC	TTC	-	rs3176652		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:100455962_100455964delTTC	ENST00000375128.4	-	2	314_316	c.250_252delGAA	c.(250-252)del	p.E84del		NM_000380.3	NP_000371.1	P23025	XPA_HUMAN	xeroderma pigmentosum, complementation group A	84	Interaction with CEP164 and required for UV resistance.|Poly-Glu.				nucleotide-excision repair, DNA damage removal	nucleoplasm	damaged DNA binding|metal ion binding|nucleotide binding|protein domain specific binding|protein homodimerization activity	p.E84*(1)		breast(1)|endometrium(4)|large_intestine(1)|lung(4)|prostate(1)	11		Acute lymphoblastic leukemia(62;0.158)				CAATTTTCTGTTCTTCTTCTTCT	0.340			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				7	520	---	---	---	---					
DAB2IP	153090	broad.mit.edu	37	9	124522389	124522391	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:124522389_124522391delAAG	ENST00000408936.3	+	6	1023_1025	c.841_843delAAG	c.(841-843)del	p.K285del	DAB2IP_ENST00000309989.1_In_Frame_Del_p.K161del|DAB2IP_ENST00000259371.2_In_Frame_Del_p.K257del			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	285	C2.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						GGAGACCGACAAGAAGAAGAAGA	0.601													9	470	---	---	---	---					
INPP5E	56623	broad.mit.edu	37	9	139333504	139333508	+	Frame_Shift_Del	DEL	GCCCC	GCCCC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr9:139333504_139333508delGCCCC	ENST00000371712.3	-	1	766_770	c.364_368delGGGGC	c.(364-369)cfs	p.GA122fs		NM_019892.4	NP_063945.2	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase, 72 kDa	122	13 X 4 AA repeats of P-X-X-P.					cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			NS(1)|endometrium(1)|lung(4)|skin(3)	9		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		GTGGGCGGGGGCCCCGGGGCCCTCG	0.698													12	41	---	---	---	---					
INA	9118	broad.mit.edu	37	10	105048271	105048273	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr10:105048271_105048273delGAG	ENST00000369849.4	+	3	1394_1396	c.1345_1347delGAG	c.(1345-1347)del	p.E454del		NM_032727.3	NP_116116.1	Q16352	AINX_HUMAN	internexin neuronal intermediate filament protein, alpha	454	Poly-Glu.|Tail.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton	p.E449_E450delEE(1)		breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)	13				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		ACTTAAGAAAGAGGAGGAGGAGG	0.458													12	344	---	---	---	---					
TSPAN4	0	broad.mit.edu	37	11	864443	864445	+	In_Frame_Del	DEL	CTG	CTG	-	rs61867552	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr11:864443_864445delCTG	ENST00000397404.1	+	5	521_523	c.262_264delCTG	c.(262-264)del	p.L92del	TSPAN4_ENST00000409531.1_In_Frame_Del_p.L111del|TSPAN4_ENST00000397406.1_In_Frame_Del_p.L92del|TSPAN4_ENST00000525201.1_In_Frame_Del_p.L28del|TSPAN4_ENST00000397408.1_In_Frame_Del_p.L92del|TSPAN4_ENST00000346501.4_In_Frame_Del_p.L92del|TSPAN4_ENST00000397411.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000397397.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000397396.1_In_Frame_Del_p.L28del|TSPAN4_ENST00000409543.2_In_Frame_Del_p.L92del	NM_001025237.1	NP_001020408.1	O14817	TSN4_HUMAN	tetraspanin 4	92					protein complex assembly	integral to plasma membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	3		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACAGTTCTTCCTGCTGCTGCTGC	0.650													15	476	---	---	---	---					
SPON1	10418	broad.mit.edu	37	11	14063263	14063263	+	RNA	DEL	A	A	-	rs113227652		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr11:14063263delA	ENST00000310358.7	+	0	1017							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GATTGCAGGGAAAAAAAAAAA	0.423													9	72	---	---	---	---					
MALAT1	0	broad.mit.edu	37	11	65269610	65269610	+	RNA	DEL	G	G	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr11:65269610delG	ENST00000534336.1	+	0	4378					NR_002819.2																						TACTGTATCTGTTTTCCTTCA	0.418													116	22	---	---	---	---					
CADM1	23705	broad.mit.edu	37	11	115080312	115080314	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr11:115080312_115080314delTGG	ENST00000537058.1	-	8	1078_1080	c.1058_1060delCCA	c.(1057-1062)atc>a	p.TI353del	CADM1_ENST00000331581.6_In_Frame_Del_p.TI353del|CADM1_ENST00000536727.1_Intron|CADM1_ENST00000537140.1_Intron|CADM1_ENST00000542447.2_Intron|CADM1_ENST00000452722.2_In_Frame_Del_p.TI353del			Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	353				PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		atggtaaggatggtggtggtggt	0.429													7	233	---	---	---	---					
IFT46	56912	broad.mit.edu	37	11	118427645	118427647	+	In_Frame_Del	DEL	TCA	TCA	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr11:118427645_118427647delTCA	ENST00000264020.2	-	5	689_691	c.312_314delTGA	c.(310-315)gaa>ga	p.DE104del	IFT46_ENST00000530872.1_In_Frame_Del_p.DE104del|IFT46_ENST00000264021.3_In_Frame_Del_p.DE53del	NM_020153.3	NP_064538.3	Q9NQC8	IFT46_HUMAN	intraflagellar transport 46 homolog (Chlamydomonas)	53					flagellum assembly|intraflagellar transport|protein stabilization	microtubule basal body|microtubule-based flagellum|nucleus	protein C-terminus binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9						TCCATGCTCTTCATCATCATCAT	0.473													7	633	---	---	---	---					
CHD4	1108	broad.mit.edu	37	12	6711207	6711209	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:6711207_6711209delCTT	ENST00000309577.6	-	4	518_520	c.355_357delAAG	c.(355-357)del	p.K119del	CHD4_ENST00000544484.1_In_Frame_Del_p.K116del|CHD4_ENST00000357008.2_In_Frame_Del_p.K119del|CHD4_ENST00000544040.1_In_Frame_Del_p.K112del			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	119	Poly-Lys.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding	p.K119delK(3)		central_nervous_system(2)	2						TAGGTCCAAGCTTCTTCTTCTTC	0.537													11	219	---	---	---	---					
PLCZ1	89869	broad.mit.edu	37	12	18841025	18841025	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:18841025delT	ENST00000266505.7	-	13	1852	c.1589delA	c.(1588-1590)atfs	p.N530fs	PLCZ1_ENST00000541695.1_Frame_Shift_Del_p.N393fs|PLCZ1_ENST00000539875.1_Frame_Shift_Del_p.N337fs|PLCZ1_ENST00000435379.1_Frame_Shift_Del_p.N335fs|PLCZ1_ENST00000538330.1_Frame_Shift_Del_p.N312fs|PLCZ1_ENST00000447925.2_Frame_Shift_Del_p.N528fs|PLCZ1_ENST00000534932.1_Frame_Shift_Del_p.N11fs			Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	530	C2.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					GAGCTCACCATTTTTTTTAAT	0.294													7	509	---	---	---	---					
SENP1	29843	broad.mit.edu	37	12	48458896	48458896	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:48458896delT	ENST00000004980.5	-	12	1705	c.1227delA	c.(1225-1227)aafs	p.K409fs	SENP1_ENST00000339976.6_3'UTR|SENP1_ENST00000549518.1_Frame_Shift_Del_p.K409fs|SENP1_ENST00000549595.1_Frame_Shift_Del_p.K409fs|SENP1_ENST00000551330.1_Frame_Shift_Del_p.K409fs|SENP1_ENST00000448372.1_Frame_Shift_Del_p.K409fs			Q9P0U3	SENP1_HUMAN	SUMO1/sentrin specific peptidase 1	409					activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity	p.G410fs*3(1)|p.G410fs*4(1)		large_intestine(3)|lung(1)|pancreas(2)|stomach(1)	7		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				ATTTATGACCTTTTTTTTGTG	0.338													7	364	---	---	---	---					
DDN	23109	broad.mit.edu	37	12	49392358	49392359	+	Frame_Shift_Ins	INS	-	-	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:49392358_49392359insC	ENST00000421952.2	-	2	321_322	c.300_301insG	c.(298-303)ggccctfs	p.GP100fs	RP11-386G11.5_ENST00000552284.1_RNA|RP11-386G11.5_ENST00000547866.1_RNA|RP11-386G11.5_ENST00000547395.1_RNA|RP11-386G11.5_ENST00000552933.1_RNA	NM_015086.1	NP_055901.2	O94850	DEND_HUMAN	dendrin	100						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	8						TCGGCCAGGGGCCCCGCCCGCC	0.723													7	188	---	---	---	---					
OR6C75	390323	broad.mit.edu	37	12	55759192	55759192	+	Frame_Shift_Del	DEL	T	T	-	rs75456529		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:55759192delT	ENST00000343399.3	+	1	298	c.298delT	c.(298-300)ttfs	p.F102fs		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						GGCTCAGCTATTTTTTTTCAT	0.438													8	1105	---	---	---	---					
TMEM19	55266	broad.mit.edu	37	12	72094757	72094757	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:72094757delT	ENST00000266673.5	+	6	1587	c.993delT	c.(991-993)ggfs	p.G331fs		NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	331						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CTGCTTGGGGTTTTTGGCCCA	0.433													9	1423	---	---	---	---					
PLXNC1	10154	broad.mit.edu	37	12	94658979	94658980	+	Frame_Shift_Ins	INS	-	-	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:94658979_94658980insG	ENST00000258526.4	+	21	3824_3825	c.3575_3576insG	c.(3574-3576)cgtfs	p.R1192fs	PLXNC1_ENST00000545312.1_5'UTR|PLXNC1_ENST00000547057.1_Frame_Shift_Ins_p.R239fs	NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	1192					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						CTGTTGTGGCAGGTTCCGGAAT	0.465													9	1840	---	---	---	---					
C12orf42	374470	broad.mit.edu	37	12	103695960	103695960	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:103695960delG	ENST00000548048.1	-	9	1304	c.808delC	c.(808-810)gcfs	p.R270fs	C12orf42_ENST00000378113.2_Frame_Shift_Del_p.R337fs|C12orf42_ENST00000315192.8_Intron|C12orf42_ENST00000548883.1_Frame_Shift_Del_p.R337fs			Q96LP6	CL042_HUMAN	chromosome 12 open reading frame 42	337										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)	22						CGGGTTGGGCGGGGGGGTGCT	0.587													8	741	---	---	---	---					
SBNO1	55206	broad.mit.edu	37	12	123794283	123794283	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:123794283delT	ENST00000420886.2	-	25	3415	c.3416delA	c.(3415-3417)atfs	p.N1139fs	SBNO1_ENST00000267176.4_Frame_Shift_Del_p.N1138fs|SBNO1_ENST00000602398.1_Frame_Shift_Del_p.N1139fs|SBNO1_ENST00000602750.1_Frame_Shift_Del_p.N1138fs	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	1139							ATP binding|DNA binding|hydrolase activity	p.N1138fs*9(1)		NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		ATATCTTCCATTTTTTTTGGC	0.388													13	1011	---	---	---	---					
DDX55	57696	broad.mit.edu	37	12	124103201	124103202	+	Translation_Start_Site	DEL	TG	TG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:124103201_124103202delTG	ENST00000421670.3	+	0	639_640				DDX55_ENST00000541259.1_Intron|DDX55_ENST00000238146.4_Intron|DDX55_ENST00000538744.1_Intron			Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55								ATP binding|ATP-dependent helicase activity|RNA binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		GAATGTGGTATGTGTGTGTGTG	0.520											OREG0022230	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	336	---	---	---	---					
NCOR2	9612	broad.mit.edu	37	12	124848228	124848228	+	Frame_Shift_Del	DEL	G	G	-	rs12321697		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:124848228delG	ENST00000356219.3	-	22	3080	c.2925delC	c.(2923-2925)ccfs	p.P975fs	NCOR2_ENST00000397355.1_Frame_Shift_Del_p.P958fs|NCOR2_ENST00000404121.2_Frame_Shift_Del_p.P528fs|NCOR2_ENST00000404621.1_Frame_Shift_Del_p.P957fs|NCOR2_ENST00000429285.2_Frame_Shift_Del_p.P957fs|NCOR2_ENST00000405201.1_Frame_Shift_Del_p.P975fs	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	975					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CACTCACGATGGGGGGGATGG	0.652													8	1075	---	---	---	---					
POLE	5426	broad.mit.edu	37	12	133220099	133220100	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr12:133220099_133220100delCA	ENST00000320574.5	-	34	4380_4381	c.4337_4338delTG	c.(4336-4338)gfs	p.V1447fs	POLE_ENST00000535270.1_Frame_Shift_Del_p.V1420fs	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1447					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GTTTATTGACCACACACACACA	0.604								DNA polymerases (catalytic subunits)					32	1608	---	---	---	---					
HSPH1	10808	broad.mit.edu	37	13	31715381	31715382	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr13:31715381_31715382insT	ENST00000320027.5	-	13	2075_2076	c.1731_1732insA	c.(1729-1734)aattgafs	p.N*577fs	HSPH1_ENST00000445273.2_Frame_Shift_Ins_p.N*579fs|HSPH1_ENST00000380405.4_Frame_Shift_Ins_p.N*533fs|HSPH1_ENST00000429785.2_Frame_Shift_Ins_p.N*396fs|HSPH1_ENST00000380406.5_Frame_Shift_Ins_p.N*536fs	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	577					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		GGCTGGTCAACTTTTTTTTCAT	0.376													8	647	---	---	---	---					
ELF1	1997	broad.mit.edu	37	13	41532986	41532988	+	In_Frame_Del	DEL	TCA	TCA	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr13:41532986_41532988delTCA	ENST00000239882.3	-	3	551_553	c.237_239delTGA	c.(235-240)gac>ga	p.DD79del	ELF1_ENST00000498824.1_5'UTR|ELF1_ENST00000442101.1_In_Frame_Del_p.DD79del	NM_172373.3	NP_758961.1	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription factor)	79	Poly-Asp.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		AAGGGTGATGTCATCATCATCAT	0.483													7	647	---	---	---	---					
SLITRK5	26050	broad.mit.edu	37	13	88329794	88329796	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr13:88329794_88329796delCGG	ENST00000325089.6	+	2	2370_2372	c.2151_2153delCGG	c.(2149-2154)tac>ta	p.YG717del	SLITRK5_ENST00000400028.3_In_Frame_Del_p.YG476del	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	717						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ACAGCGTGTACGGCGGCGGCGGC	0.645													8	515	---	---	---	---					
ABCC4	10257	broad.mit.edu	37	13	95696016	95696016	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr13:95696016delT	ENST00000376887.4	-	29	3769	c.3655delA	c.(3655-3657)tcfs	p.I1219fs	ABCC4_ENST00000412704.1_Frame_Shift_Del_p.I1172fs	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	1219	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TTCTCCCGGATTTTTTTTTGT	0.378													8	564	---	---	---	---					
IL25	0	broad.mit.edu	37	14	23845057	23845058	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr14:23845057_23845058delTG	ENST00000329715.2	+	2	760_761	c.502_503delTG	c.(502-504)tfs	p.C168fs	IL25_ENST00000397242.2_Frame_Shift_Del_p.C152fs	NM_022789.3	NP_073626.1	Q9H293	IL25_HUMAN	interleukin 25	168					inflammatory response	extracellular space|membrane	cytokine activity|interleukin-17E receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	9	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.00665)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0396)		TTCCTTAGCTTGTGTGTGTGTG	0.604													14	905	---	---	---	---					
MGAT2	4247	broad.mit.edu	37	14	50088327	50088327	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr14:50088327delC	ENST00000305386.2	+	1	839	c.341delC	c.(340-342)gcfs	p.A114fs	RP11-649E7.5_ENST00000555043.1_RNA	NM_002408.3	NP_002399.1	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	114					oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)	11	all_epithelial(31;0.0021)|Breast(41;0.0124)					GGCACCTGGGCCCCCCGGGAG	0.602													7	1182	---	---	---	---					
HSP90AA1	3320	broad.mit.edu	37	14	102551161	102551163	+	In_Frame_Del	DEL	TCT	TCT	-	rs55793809	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr14:102551161_102551163delTCT	ENST00000334701.7	-	6	1483_1485	c.1202_1204delAGA	c.(1201-1206)att>a	p.KI401del	HSP90AA1_ENST00000441629.2_In_Frame_Del_p.KI100del|HSP90AA1_ENST00000216281.8_In_Frame_Del_p.KI279del	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	279					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	ttttccttaatcttcttcttctt	0.389													7	340	---	---	---	---					
ZNF106	64397	broad.mit.edu	37	15	42742957	42742957	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:42742957delA	ENST00000263805.4	-	2	1770	c.1444delT	c.(1444-1446)ccfs	p.S482fs	ZNF106_ENST00000565380.1_Intron|ZNF106_ENST00000565611.1_Intron	NM_022473.1	NP_071918.1			zinc finger protein 106																		TCTCCAGGGGAAAAAAAATTT	0.393													7	817	---	---	---	---					
HMGN2P46	0	broad.mit.edu	37	15	45848231	45848231	+	RNA	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:45848231delT	ENST00000409454.1	+	0	1226																											TTTGTTTAGCTTTTTTTTTTT	0.323													15	59	---	---	---	---					
ZNF609	23060	broad.mit.edu	37	15	64967246	64967247	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:64967246_64967247insA	ENST00000326648.3	+	4	2321_2322	c.2193_2194insA	c.(2191-2196)gaaaaafs	p.EK731fs		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	731	Poly-Lys.					nucleus	zinc ion binding	p.K734fs*12(1)		breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AAAAGAAAGACAAAAAAAAGAA	0.490													7	638	---	---	---	---					
PIAS1	8554	broad.mit.edu	37	15	68379085	68379089	+	Splice_Site	DEL	CTAGG	CTAGG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:68379085_68379089delCTAGG	ENST00000545237.1	+	3	1213_1216	c.475_splice	c.e3+1	p.158_splice	PIAS1_ENST00000249636.6_Splice_Site_p.156_splice			O75925	PIAS1_HUMAN	protein inhibitor of activated STAT, 1	156	PINIT.				androgen receptor signaling pathway|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|positive regulation of protein sumoylation|positive regulation of transcription, DNA-dependent|regulation of interferon-gamma-mediated signaling pathway|transcription, DNA-dependent	nuclear speck	androgen receptor binding|DNA binding|enzyme binding|SUMO ligase activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)	24						ACCCACCAGTCTAGGTAAGATTATT	0.327													62	23	---	---	---	---					
CSPG4P5	0	broad.mit.edu	37	15	84958415	84958426	+	RNA	DEL	CGAGGACATTGG	CGAGGACATTGG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr15:84958415_84958426delCGAGGACATTGG	ENST00000558801.1	-	0	6303_6314																											TCGGGCACCACGAGGACATTGGTGAGGACAGG	0.557													3	4	---	---	---	---					
KNOP1	400506	broad.mit.edu	37	16	19722724	19722724	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr16:19722724delT	ENST00000219837.7	-	3	1035	c.957delA	c.(955-957)aafs	p.K319fs	AC002550.5_ENST00000565916.1_RNA|KNOP1_ENST00000568230.1_5'UTR	NM_001012991.2	NP_001013009.2			lysine-rich nucleolar protein 1									p.G320fs*5(1)|p.K319N(1)									CCATGTTGCCTTTTTTTTCCA	0.562													8	303	---	---	---	---					
IRX6	79190	broad.mit.edu	37	16	55362674	55362676	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr16:55362674_55362676delGAG	ENST00000290552.7	+	5	2116_2118	c.784_786delGAG	c.(784-786)del	p.E268del	RP11-26L20.3_ENST00000558730.2_RNA	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	268						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						CCTggaggaagaggaggaggagg	0.626													11	270	---	---	---	---					
NOB1	28987	broad.mit.edu	37	16	69782978	69782980	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr16:69782978_69782980delTCC	ENST00000268802.5	-	6	596_598	c.567_569delGGA	c.(565-570)gaa>ga	p.EE189del		NM_014062.1	NP_054781.1	Q9ULX3	NOB1_HUMAN	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)	189	Poly-Glu.					nucleus	metal ion binding|protein binding			breast(2)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						CCCGTTTTCTTCCTCCTCCTCCT	0.522													10	279	---	---	---	---					
ADAMTS18	170692	broad.mit.edu	37	16	77356311	77356311	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr16:77356311delA	ENST00000282849.5	-	14	2503	c.2085delT	c.(2083-2085)ttfs	p.F695fs		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	695	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.A696fs*18(2)		NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						CGGACATTGCAAAAAAAAATT	0.403													8	385	---	---	---	---					
SPIRE2	84501	broad.mit.edu	37	16	89916879	89916880	+	In_Frame_Ins	INS	-	-	GAG	rs146569219	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr16:89916879_89916880insGAG	ENST00000378247.3	+	3	499_500	c.456_457insGAG	c.(454-459)ccagga>ccGAGagga	p.152_153PG>PRG	SPIRE2_ENST00000564878.1_3'UTR|SPIRE2_ENST00000393062.2_In_Frame_Ins_p.152_153PG>PRG	NM_032451.1	NP_115827.1	Q8WWL2	SPIR2_HUMAN	spire-type actin nucleation factor 2	152	KIND.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		ACGGGGGTCCCGAGGAGGAGGA	0.728													26	15	---	---	---	---					
NDEL1	81565	broad.mit.edu	37	17	8370271	8370273	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:8370271_8370273delCTC	ENST00000334527.7	+	9	1165_1167	c.968_970delCTC	c.(967-972)gct>g	p.AP323del	NDEL1_ENST00000585098.1_Intron|NDEL1_ENST00000402554.3_3'UTR|NDEL1_ENST00000380025.4_3'UTR|NDEL1_ENST00000299734.7_Intron	NM_030808.4	NP_110435.1	Q9GZM8	NDEL1_HUMAN	nudE neurodevelopment protein 1-like 1	323	Interaction with CENPF.|Interaction with NEFL (By similarity).				chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|microtubule|spindle				large_intestine(6)|lung(4)|skin(3)	13						TTTGACCCCGCTCCTCCTCCTCC	0.576													9	772	---	---	---	---					
MYH10	4628	broad.mit.edu	37	17	8415820	8415822	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:8415820_8415822delTTC	ENST00000360416.3	-	24	3037_3039	c.2899_2901delGAA	c.(2899-2901)del	p.E967del	MYH10_ENST00000396239.1_In_Frame_Del_p.E957del|MYH10_ENST00000269243.4_In_Frame_Del_p.E936del|MYH10_ENST00000379980.4_In_Frame_Del_p.E952del	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	936					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TTTGGTTTCTTTCTTCTTCTTCT	0.350													7	598	---	---	---	---					
WDR16	146845	broad.mit.edu	37	17	9503387	9503389	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:9503387_9503389delGAT	ENST00000352665.5	+	6	709_711	c.640_642delGAT	c.(640-642)del	p.D217del	WDR16_ENST00000396219.3_In_Frame_Del_p.D149del|WDR16_ENST00000299764.5_In_Frame_Del_p.D227del	NM_145054.4	NP_659491.4	Q8N1V2	WDR16_HUMAN	WD repeat domain 16	217						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31						TCTTCAGGTGGATGATGATGATA	0.502													8	808	---	---	---	---					
MYO15A	51168	broad.mit.edu	37	17	18023292	18023293	+	Frame_Shift_Ins	INS	-	-	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:18023292_18023293insC	ENST00000205890.5	+	2	1516_1517	c.1178_1179insC	c.(1177-1179)tccfs	p.S393fs		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	393	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					GAGGCCATCTACCCCCCCGAGG	0.619													11	872	---	---	---	---					
SMCR7	0	broad.mit.edu	37	17	18167778	18167780	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:18167778_18167780delGCT	ENST00000323019.4	+	4	1276_1278	c.1065_1067delGCT	c.(1063-1068)cgg>cg	p.RL355del	SMCR7_ENST00000395706.2_In_Frame_Del_p.RL366del|SMCR7_ENST00000395704.4_3'UTR	NM_001144900.1|NM_139162.3	NP_001138372.1|NP_631901.2	Q96C03	SMCR7_HUMAN		355						integral to membrane	protein binding	p.L356R(1)		breast(1)|central_nervous_system(1)|endometrium(3)|lung(4)	9	all_neural(463;0.228)					CTCGCCGGCGGCTGCTGCTGCTG	0.685													9	515	---	---	---	---					
NSRP1	84081	broad.mit.edu	37	17	28505166	28505167	+	Frame_Shift_Ins	INS	-	-	A	rs143842750	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:28505166_28505167insA	ENST00000247026.5	+	4	312_313	c.249_250insA	c.(247-252)caaaaafs	p.QK83fs	NSRP1_ENST00000540900.3_3'UTR	NM_001261467.1|NM_032141.3	NP_001248396.1|NP_115517.1	Q9H0G5	NSRP1_HUMAN	nuclear speckle splicing regulatory protein 1	83					developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding			autonomic_ganglia(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	14						ATGAAATGCAGAAAAAAAAGGA	0.332													7	534	---	---	---	---					
PLCD3	113026	broad.mit.edu	37	17	43192760	43192762	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:43192760_43192762delTCC	ENST00000322765.5	-	9	1622_1624	c.1509_1511delGGA	c.(1507-1512)gat>ga	p.ED503del	PLCD3_ENST00000540511.1_5'UTR	NM_133373.3	NP_588614.1	Q8N3E9	PLCD3_HUMAN	phospholipase C, delta 3	503					intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.E503D(2)		breast(2)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	17					Phosphatidylserine(DB00144)	ctcctcgtcatcctcctcctcct	0.670													8	145	---	---	---	---					
COIL	8161	broad.mit.edu	37	17	55028016	55028016	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:55028016delT	ENST00000240316.4	-	2	621	c.587delA	c.(586-588)agfs	p.K196fs		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	196	Lys-rich (basic).					Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					ATTCTTAGCCTTTTTTTTATA	0.393													8	726	---	---	---	---					
LGALS3BP	3959	broad.mit.edu	37	17	76967722	76967723	+	Frame_Shift_Ins	INS	-	-	G			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr17:76967722_76967723insG	ENST00000262776.3	-	6	2001_2002	c.1693_1694insC	c.(1693-1695)cttfs	p.L565fs	LGALS3BP_ENST00000591778.1_3'UTR	NM_005567.3	NP_005558.1	Q08380	LG3BP_HUMAN	lectin, galactoside-binding, soluble, 3 binding protein	565					cell adhesion|cellular defense response	extracellular space|membrane|proteinaceous extracellular matrix	protein binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(5)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(99;0.0677)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			GCCGTTGAAGTGCCCTGCCGGG	0.634											OREG0024787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	291	---	---	---	---					
CXXC1	30827	broad.mit.edu	37	18	47812275	47812277	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr18:47812275_47812277delCTG	ENST00000285106.6	-	5	1195_1197	c.481_483delCAG	c.(481-483)del	p.Q161del	CXXC1_ENST00000589940.1_In_Frame_Del_p.Q161del|CXXC1_ENST00000412036.2_In_Frame_Del_p.Q161del	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	161					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						ACCGTTTGATctgctgctgctgc	0.557													8	251	---	---	---	---					
CATSPERD	257062	broad.mit.edu	37	19	5744474	5744474	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:5744474delT	ENST00000381624.3	+	8	671	c.610delT	c.(610-612)ttfs	p.F205fs	CATSPERD_ENST00000381614.2_5'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	205						integral to membrane											AATCTTCCACTTTTTTTCTTT	0.413													7	1075	---	---	---	---					
PDE4A	5141	broad.mit.edu	37	19	10578143	10578144	+	Frame_Shift_Ins	INS	-	-	C			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:10578143_10578144insC	ENST00000380702.2	+	16	2441_2442	c.2441_2442insC	c.(2440-2442)cccfs	p.P814fs	PDE4A_ENST00000440014.2_Frame_Shift_Ins_p.P775fs|PDE4A_ENST00000352831.6_Frame_Shift_Ins_p.P836fs|PDE4A_ENST00000592685.1_Frame_Shift_Ins_p.P814fs|PDE4A_ENST00000344979.3_Frame_Shift_Ins_p.P597fs|PDE4A_ENST00000293683.5_Frame_Shift_Ins_p.P810fs			P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	836					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	GCCCCGGGCCTCCCGGGCCTCC	0.663													7	1139	---	---	---	---					
FFAR2	2867	broad.mit.edu	37	19	35940788	35940790	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:35940788_35940790delCTG	ENST00000599180.1	+	2	252_254	c.172_174delCTG	c.(172-174)del	p.L62del	FFAR2_ENST00000246549.2_In_Frame_Del_p.L62del|FFAR2_ENST00000601590.1_Intron			O15552	FFAR2_HUMAN	free fatty acid receptor 2	62						integral to plasma membrane	G-protein coupled receptor activity|lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(6)|skin(1)|urinary_tract(1)	22	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CGACCTCCTCCTGCTGCTGCTGC	0.645													9	298	---	---	---	---					
ATP4A	495	broad.mit.edu	37	19	36054349	36054351	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:36054349_36054351delCTT	ENST00000262623.3	-	2	119_121	c.91_93delAAG	c.(91-93)del	p.K31del		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	31					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	CGCCACCCGCCTTCTTCTTCTTG	0.601													7	1743	---	---	---	---					
C19orf55	148137	broad.mit.edu	37	19	36255947	36255949	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr19:36255947_36255949delCTC	ENST00000544099.1	+	7	702_704	c.639_641delCTC	c.(637-642)atc>at	p.IS213del	C19orf55_ENST00000396908.4_In_Frame_Del_p.IS213del			Q2NL68	CS055_HUMAN	chromosome 19 open reading frame 55	213	Ser-rich.									cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)	15	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAGCCTCCATCTCCTCCTCCTCC	0.631													14	1820	---	---	---	---					
CD93	22918	broad.mit.edu	37	20	23065887	23065887	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:23065887delC	ENST00000246006.4	-	1	1090	c.943delG	c.(943-945)ccfs	p.A315fs		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	315	EGF-like 2.				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					ACGCACGTGGCCCCCCCACGA	0.637													7	517	---	---	---	---					
NCOA6	23054	broad.mit.edu	37	20	33330968	33330970	+	In_Frame_Del	DEL	TGC	TGC	-	rs140426729	byFrequency	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:33330968_33330970delTGC	ENST00000374796.2	-	12	5660_5662	c.3090_3092delGCA	c.(3088-3093)caa>ca	p.QQ1030del	NCOA6_ENST00000359003.2_In_Frame_Del_p.QQ1030del			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1030	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						CATCATTtgttgctgctgctgct	0.576													11	672	---	---	---	---					
SYCP2	10388	broad.mit.edu	37	20	58452518	58452519	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr20:58452518_58452519insT	ENST00000357552.3	-	33	3296_3297	c.3071_3072insA	c.(3070-3072)atafs	p.I1024fs	SYCP2_ENST00000371001.2_Frame_Shift_Ins_p.I1024fs			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1024					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			GATCTTTATAGTTTTTTTTTGT	0.327													10	566	---	---	---	---					
CBR3-AS1	0	broad.mit.edu	37	21	37518893	37518894	+	RNA	INS	-	-	T	rs113213749		TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr21:37518893_37518894insT	ENST00000413862.1	-	0	79				CBR3-AS1_ENST00000427491.1_RNA|CBR3-AS1_ENST00000453159.1_RNA	NR_038892.1																						tatttctgttcttttttttttt	0.450													8	57	---	---	---	---					
TPTEP1	0	broad.mit.edu	37	22	17127506	17127507	+	RNA	INS	-	-	A			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr22:17127506_17127507insA	ENST00000426585.1	+	0	442																											AGGGCCTAGAGAAAAAAAAAAT	0.421													8	200	---	---	---	---					
TRIOBP	11078	broad.mit.edu	37	22	38120323	38120325	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr22:38120323_38120325delCCT	ENST00000406386.3	+	7	2015_2017	c.1760_1762delCCT	c.(1759-1764)gcc>g	p.AS587del	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	587					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AATCCCAGAGCCTCCTCTCCCAA	0.596													15	920	---	---	---	---					
CYP2D7P1	0	broad.mit.edu	37	22	42537119	42537120	+	RNA	INS	-	-	A	rs142656198	by1000genomes	TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chr22:42537119_42537120insA	ENST00000435101.1	-	0	296				CYP2D7P1_ENST00000358097.4_RNA|CYP2D7P1_ENST00000433992.1_RNA																endometrium(1)	1						GGGCTACCACCGGGGCTGATGC	0.614													4	5	---	---	---	---					
XIST	0	broad.mit.edu	37	X	73071762	73071762	+	RNA	DEL	A	A	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chrX:73071762delA	ENST00000429829.1	-	0	826					NR_001564.2																						GATCAGCAGCAAAAAAAAGTG	0.413													8	421	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76778853	76778879	+	Splice_Site	DEL	CTGAAGGAGCTCTGCAAGTATGGTATC	CTGAAGGAGCTCTGCAAGTATGGTATC	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chrX:76778853_76778879delCTGAAGGAGCTCTGCAAGTATGGTATC	ENST00000373344.5	-	31	6914_6940	c.6699_splice	c.e31-1	p.DTILAELLQ2234_splice	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Splice_Site_p.DTILAELLQ2196_splice	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	2234					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.D2234G(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	CTTTATGTATCTGAAGGAGCTCTGCAAGTATGGTATCCTGTTTAGAG	0.379			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						127	234	---	---	---	---					
BHLHB9	80823	broad.mit.edu	37	X	102004419	102004421	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chrX:102004419_102004421delGAG	ENST00000372735.1	+	4	1081_1083	c.496_498delGAG	c.(496-498)del	p.E171del	BHLHB9_ENST00000448867.1_In_Frame_Del_p.E171del|BHLHB9_ENST00000457056.1_In_Frame_Del_p.E171del|BHLHB9_ENST00000361229.4_In_Frame_Del_p.E171del|BHLHB9_ENST00000447531.1_In_Frame_Del_p.E171del			Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class B, 9	171	Poly-Glu.					cytoplasm|nucleus	binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GTCAGGGGCTGAGGAGGAGGAGG	0.488													17	768	---	---	---	---					
PAK3	5063	broad.mit.edu	37	X	110406206	110406208	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chrX:110406206_110406208delGAA	ENST00000519681.1	+	10	1037_1039	c.595_597delGAA	c.(595-597)del	p.E203del	PAK3_ENST00000518291.1_In_Frame_Del_p.E218del|PAK3_ENST00000446737.1_In_Frame_Del_p.E182del|PAK3_ENST00000425146.1_In_Frame_Del_p.E182del|PAK3_ENST00000360648.4_In_Frame_Del_p.E218del|PAK3_ENST00000262836.4_In_Frame_Del_p.E197del|PAK3_ENST00000372007.4_In_Frame_Del_p.E182del|PAK3_ENST00000372010.1_In_Frame_Del_p.E197del|PAK3_ENST00000417227.1_In_Frame_Del_p.E203del			O75914	PAK3_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 3	197	Linker.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						agatgaagaggaagaagaagaag	0.394										TSP Lung(19;0.15)			8	535	---	---	---	---					
MAMLD1	10046	broad.mit.edu	37	X	149639633	149639635	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-3A-A9IV-01A-11D-A40W-08	TCGA-3A-A9IV-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57ebcf76-a502-4b1f-9d5c-f1d692e04e07	a7be39be-646d-47be-ba27-cc833afeac15	g.chrX:149639633_149639635delGCA	ENST00000370401.2	+	4	2098_2100	c.1788_1790delGCA	c.(1786-1791)ctg>ct	p.LQ596del	MAMLD1_ENST00000262858.5_In_Frame_Del_p.LQ596del|MAMLD1_ENST00000426613.2_In_Frame_Del_p.LQ571del|MAMLD1_ENST00000455522.2_In_Frame_Del_p.LQ77del|MAMLD1_ENST00000432680.2_In_Frame_Del_p.LQ571del			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	596	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					CCTTgcagctgcagcagcagcag	0.611													8	392	---	---	---	---					
