Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PTENP1	0	broad.mit.edu	37	9	33675379	33675379	+	RNA	SNP	C	C	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr9:33675379C>A	ENST00000532280.1	-	0	2118					NR_023917.1																						AAAAAGGTCCCTTTTCAGTTT	0.318000													5	230					1.23904e-05	1.36947e-05	1	1	0
OR2G6	391211	broad.mit.edu	37	1	248685682	248685682	+	Silent	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr1:248685682G>A	ENST00000343414.4	+	1	767	c.735G>A	c.(733-735)ctG>ctA	p.L245L		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGTCTCACCTGGTTGTGGTCA	0.438000													12	614					0	0	1	0	0
PJA2	9867	broad.mit.edu	37	5	108717235	108717235	+	Silent	SNP	T	T	C			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr5:108717235T>C	ENST00000361189.2	-	3	440	c.201A>G	c.(199-201)gaA>gaG	p.E67E	PJA2_ENST00000361557.3_Silent_p.E67E|PJA2_ENST00000511624.1_5'UTR	NM_014819.4	NP_055634.3	O43164	PJA2_HUMAN	praja ring finger 2, E3 ubiquitin protein ligase	67					long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		CATCATCTAGTTCCAACACTT	0.323000													9	294					0	0	1	0	0
CCT6P1	0	broad.mit.edu	37	7	65226641	65226641	+	RNA	SNP	G	G	T			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr7:65226641G>T	ENST00000442266.1	+	0	1167																											AGGTTCTTGCGCAGAATTCTG	0.383000													4	129					0.150653	0.155593	1	1	0
SFMBT1	51460	broad.mit.edu	37	3	52940182	52940182	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr3:52940182G>A	ENST00000394752.3	-	20	2789	c.2407C>T	c.(2407-2409)Cgg>Tgg	p.R803W	SFMBT1_ENST00000358080.2_Missense_Mutation_p.R803W|SFMBT1_ENST00000296295.6_Intron|SFMBT1_ENST00000394750.1_Missense_Mutation_p.R803W	NM_016329.3	NP_057413.2	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	803	SAM.				regulation of transcription, DNA-dependent	nucleus				breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	24				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		CTGATGAACCGCACAACGTCT	0.418000													5	375					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21731270	21731270	+	Missense_Mutation	SNP	T	T	C			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr17:21731270T>C	ENST00000584755.1	+	2	969	c.572T>C	c.(571-573)aTc>aCc	p.I191T	UBBP4_ENST00000578713.1_Intron|UBBP4_ENST00000583708.1_3'UTR														p.I191T(3)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						ATCCCCCCGATCAGCAGAGGC	0.547000													5	406					0	0	1	0	0
PCDHB6	0	broad.mit.edu	37	5	140531966	140531966	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr5:140531966C>T	ENST00000231136.1	+	1	2128	c.2128C>T	c.(2128-2130)Cgg>Tgg	p.R710W	PCDHB6_ENST00000543635.1_Missense_Mutation_p.R574W	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		710					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGTGGCGGTGCGGCTGTGCAG	0.677000													8	947					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21051256	21051256	+	Missense_Mutation	SNP	G	G	A	rs141534193	byFrequency	TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr16:21051256G>A	ENST00000261383.3	-	33	4647	c.4648C>T	c.(4648-4650)Cgg>Tgg	p.R1550W	DNAH3_ENST00000415178.1_Missense_Mutation_p.R1550W	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1550	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.R1550W(2)		NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GCCACTGTCCGGAACAAGGCC	0.483000													7	326					0	0	1	0	0
IRF8	3394	broad.mit.edu	37	16	85942713	85942713	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr16:85942713C>T	ENST00000268638.5	+	3	714	c.292C>T	c.(292-294)Cgg>Tgg	p.R98W	IRF8_ENST00000563180.1_Missense_Mutation_p.R98W	NM_002163.2	NP_002154.1	Q02556	IRF8_HUMAN	interferon regulatory factor 8	98					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	24		Prostate(104;0.0771)				AGTGACGGACCGGTCCCAACT	0.458000													6	306					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807121	20807121	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr19:20807121G>A	ENST00000601440.1	-	4	1708	c.1562C>T	c.(1561-1563)cCt>cTt	p.P521L	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						TAAGGTGTGAGGACCGCTTGA	0.378000													6	404					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57484420	57484420	+	Missense_Mutation	SNP	C	C	T	rs11554273		TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr20:57484420C>T	ENST00000371100.4	+	8	3082	c.2530C>T	c.(2530-2532)Cgt>Tgt	p.R844C	GNAS_ENST00000265620.7_Missense_Mutation_p.R186C|GNAS_ENST00000371095.3_Missense_Mutation_p.R187C|GNAS_ENST00000371102.4_Missense_Mutation_p.R830C|GNAS_ENST00000371075.3_3'UTR|GNAS_ENST00000354359.7_Missense_Mutation_p.R202C|GNAS_ENST00000371085.3_Missense_Mutation_p.R201C|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000306090.10_Missense_Mutation_p.R187C|GNAS_ENST00000313949.7_3'UTR	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	201					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity	p.R201C(228)|p.R844C(9)|p.R201S(5)		adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GCTTCGCTGCCGTGTCCTGAC	0.428000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			5	305					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907820	12907820	+	Missense_Mutation	SNP	G	G	T			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr1:12907820G>T	ENST00000317869.6	-	2	548	c.323C>A	c.(322-324)tCt>tAt	p.S108Y		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						CAAGTCAAAAGAGGAGCCGTA	0.493000													10	535					0.335167	0.340573	1	1	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr12:25398284C>A	ENST00000311936.3	-	2	226	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000256078.4_Missense_Mutation_p.G12V|KRAS_ENST00000556131.1_Missense_Mutation_p.G12V	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			5	306					0.000602214	0.000654129	1	1	0
IPCEF1	26034	broad.mit.edu	37	6	154489200	154489200	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr6:154489200G>A	ENST00000265198.4	-	11	1111	c.956C>T	c.(955-957)tCa>tTa	p.S319L	IPCEF1_ENST00000519344.1_Missense_Mutation_p.S291L|OPRM1_ENST00000337049.4_Intron|IPCEF1_ENST00000422970.2_Missense_Mutation_p.S320L|IPCEF1_ENST00000367220.4_Missense_Mutation_p.S320L	NM_001130700.1|NM_015553.2	NP_001124172.1|NP_056368.1			interaction protein for cytohesin exchange factors 1											breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	12						TTGCTCTAATGATTTGTACAG	0.358000													17	1366					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55494521	55494521	+	Silent	SNP	C	C	T			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr19:55494521C>T	ENST00000543010.1	+	6	1598	c.1455C>T	c.(1453-1455)gaC>gaT	p.D485D	NLRP2_ENST00000339757.7_Silent_p.D463D|NLRP2_ENST00000538819.1_Silent_p.D461D|NLRP2_ENST00000427260.2_Silent_p.D462D|NLRP2_ENST00000263437.6_Silent_p.D482D|NLRP2_ENST00000537859.1_Silent_p.D463D|NLRP2_ENST00000391721.4_Silent_p.D461D|NLRP2_ENST00000448584.2_Silent_p.D485D	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	485	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		TGTTCCTGGACGGAGACATCC	0.617000													5	274					0	0	1	0	0
HSPH1	10808	broad.mit.edu	37	13	31712990	31712990	+	Silent	SNP	C	C	T			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr13:31712990C>T	ENST00000320027.5	-	16	2480	c.2136G>A	c.(2134-2136)cgG>cgA	p.R712R	HSPH1_ENST00000429785.2_Silent_p.R531R|HSPH1_ENST00000445273.2_Silent_p.R714R|HSPH1_ENST00000380405.4_Silent_p.R668R|HSPH1_ENST00000380406.5_Silent_p.R671R	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	712					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		ACATTTTTGGCCGTTCTTCAG	0.343000													7	640					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84606551	84606551	+	Missense_Mutation	SNP	T	T	C			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr9:84606551T>C	ENST00000344803.2	+	4	1213	c.1166T>C	c.(1165-1167)tTt>tCt	p.F389S		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		TCTGAGGCCTTTTTAGGGGGG	0.473000													7	224					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													5	63					0	0	1	0	0
DNAJB1	3337	broad.mit.edu	37	19	14627503	14627503	+	Silent	SNP	C	C	T	rs146528791		TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr19:14627503C>T	ENST00000254322.2	-	2	637	c.567G>A	c.(565-567)cgG>cgA	p.R189R	DNAJB1_ENST00000396969.4_Silent_p.R89R	NM_006145.1	NP_006136.1	P25685	DNJB1_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 1	189					chaperone cofactor-dependent protein refolding|response to unfolded protein	cytoplasm|nucleolus	heat shock protein binding|unfolded protein binding			NS(1)|breast(1)|cervix(3)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|urinary_tract(1)	16				GBM - Glioblastoma multiforme(1328;0.0476)		CGGGGTTTAGCCGCTTGTGGG	0.493000													7	778					0	0	1	0	0
C1orf172	126695	broad.mit.edu	37	1	27278809	27278809	+	Silent	SNP	C	C	T			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr1:27278809C>T	ENST00000320567.5	-	2	151	c.63G>A	c.(61-63)cgG>cgA	p.R21R		NM_152365.2	NP_689578.2	Q8NAX2	CA172_HUMAN	chromosome 1 open reading frame 172	21	Pro-rich.									NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		GCTCTGTTGGCCGCTCCCACG	0.647000													5	279					0	0	1	0	0
NCOR1P1	0	broad.mit.edu	37	20	26084295	26084295	+	RNA	SNP	C	C	T	rs76611503	by1000genomes	TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr20:26084295C>T	ENST00000478176.1	-	0	162					NR_003678.1													p.G41R(1)									TGTTTGCCTCCAAATGCTGGA	0.373000													5	373					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154130395	154130395	+	Missense_Mutation	SNP	G	G	A	rs137852453		TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chrX:154130395G>A	ENST00000360256.4	-	19	6246	c.6046C>T	c.(6046-6048)Cgg>Tgg	p.R2016W		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	2016	F5/8 type A 3.|Plastocyanin-like 6.		R -> P (in HEMA; severe familial).|R -> W (in HEMA; severe/moderate/mild).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CATTCCACCCGCCAAATTCCA	0.418000													7	425					0	0	1	0	0
DHX30	22907	broad.mit.edu	37	3	47891156	47891156	+	Silent	SNP	T	T	C			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr3:47891156T>C	ENST00000446256.2	+	22	3683	c.3111T>C	c.(3109-3111)taT>taC	p.Y1037Y	DHX30_ENST00000457607.1_Silent_p.Y1104Y|DHX30_ENST00000445061.1_Silent_p.Y1076Y|DHX30_ENST00000348968.4_Silent_p.Y1048Y	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	1076						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GGCTGACGTATTTCATGGCAG	0.627000													13	283					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36046466	36046466	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr19:36046466C>T	ENST00000262623.3	-	14	2061	c.2033G>A	c.(2032-2034)gGc>gAc	p.G678D		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	678					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	CAGCTGCATGCCATTGATCAC	0.652000													4	206					0	0	1	0	0
ARNT2	9915	broad.mit.edu	37	15	80845046	80845046	+	Silent	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr15:80845046G>A	ENST00000533983.1	+	11	1326	c.987G>A	c.(985-987)cgG>cgA	p.R329R	ARNT2_ENST00000527771.1_Silent_p.R329R|ARNT2_ENST00000303329.4_Silent_p.R340R			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	340	PAS 2.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			TCTTATCCCGGCATAACTCCG	0.483000													5	378					0	0	1	0	0
SEPT3	55964	broad.mit.edu	37	22	42388741	42388741	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr22:42388741G>A	ENST00000396425.3	+	8	970	c.839G>A	c.(838-840)cGa>cAa	p.R280Q	SEPT3_ENST00000291236.11_Missense_Mutation_p.R216Q|SEPT3_ENST00000328414.8_3'UTR|SEPT3_ENST00000406029.1_Missense_Mutation_p.R216Q|SEPT3_ENST00000396426.3_Missense_Mutation_p.R280Q	NM_019106.5	NP_061979.3	Q9UH03	SEPT3_HUMAN	septin 3	280					cell cycle|cytokinesis	cell junction|septin complex	GTP binding			breast(1)|kidney(3)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17						GTCCTCGGCCGAAAAACTCCA	0.488000													3	62					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62130655	62130655	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr17:62130655G>A	ENST00000433197.2	-	16	2125	c.2030C>T	c.(2029-2031)gCc>gTc	p.A677V		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	677	Protein kinase.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						GTGGAGGTGGGCCAGGCCCGA	0.612000													4	174					0	0	1	0	0
AMPD3	272	broad.mit.edu	37	11	10523050	10523050	+	Silent	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr11:10523050G>A	ENST00000444303.2	+	11	1750	c.1278G>A	c.(1276-1278)ccG>ccA	p.P426P	AMPD3_ENST00000530864.1_3'UTR|AMPD3_ENST00000396554.3_Silent_p.P594P	NM_001172431.1	NP_001165902.1	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3	585					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(3)|skin(1)	25				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		TGTTCCGGCCGCACTGTGGGG	0.632000													4	172					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153907303	153907303	+	Silent	SNP	C	C	T			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr1:153907303C>T	ENST00000361217.4	-	18	3124	c.2706G>A	c.(2704-2706)caG>caA	p.Q902Q		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	902	Gln-rich.									NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgctgctgttgctgct	0.642000													6	248					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32706462	32706462	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr2:32706462G>A	ENST00000421745.2	+	38	7617	c.7483G>A	c.(7483-7485)Gac>Aac	p.D2495N		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2495					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					AATGGAAGTTGACATTGATCC	0.383000													5	266					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79387352	79387352	+	Silent	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr1:79387352G>A	ENST00000370742.3	-	9	1266	c.1203C>T	c.(1201-1203)tgC>tgT	p.C401C		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	401	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GATTACAGCGGCATGAGGTGT	0.413000													5	412					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190592627	190592627	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr2:190592627G>A	ENST00000520309.1	+	13	2769	c.2681G>A	c.(2680-2682)cGt>cAt	p.R894H	ANKAR_ENST00000438402.2_Missense_Mutation_p.R894H|ANKAR_ENST00000431575.2_Missense_Mutation_p.R823H|ANKAR_ENST00000313581.4_Missense_Mutation_p.R894H|ANKAR_ENST00000281412.6_Missense_Mutation_p.R669H	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	894						integral to membrane	binding	p.R823H(1)		breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			GAGGTTGGGCGTGACAATAAG	0.373000													7	336					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116356341	116356341	+	Missense_Mutation	SNP	C	C	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr9:116356341C>A	ENST00000462403.1	+	1	576	c.142C>A	c.(142-144)Ctc>Atc	p.L48I	RGS3_ENST00000394646.3_Intron|RGS3_ENST00000374140.2_Intron|RGS3_ENST00000342620.5_Intron|RGS3_ENST00000374134.3_Intron|RGS3_ENST00000343817.5_Intron|RGS3_ENST00000462143.1_Intron|RGS3_ENST00000350696.5_Intron	NM_144489.2	NP_652760.2	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	0					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						TCCGCTCCCCCTCCTGGTCCC	0.622000													18	823					6.49762e-13	7.44273e-13	1	1	0
KCNK5	8645	broad.mit.edu	37	6	39162508	39162508	+	Silent	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr6:39162508G>A	ENST00000359534.3	-	3	665	c.327C>T	c.(325-327)ccC>ccT	p.P109P		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	109					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						GGCGACCGGCGGGGGTCTTGG	0.592000													8	368					0	0	1	0	0
PRDM13	59336	broad.mit.edu	37	6	100057076	100057076	+	Missense_Mutation	SNP	C	C	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr6:100057076C>A	ENST00000369214.1	+	3	581	c.320C>A	c.(319-321)gCa>gAa	p.A107E	PRDM13_ENST00000369215.4_Missense_Mutation_p.A97E	NM_021620.3	NP_067633.2	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	97	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(1)	17		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		TTCTACCGAGCATTGCGAGAC	0.507000													4	115					1	1	1	1	0
FOXP2	93986	broad.mit.edu	37	7	114269973	114269973	+	Silent	SNP	A	A	G	rs149757187		TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr7:114269973A>G	ENST00000393500.3	+	11	1105	c.285A>G	c.(283-285)caA>caG	p.Q95Q	FOXP2_ENST00000360232.4_Silent_p.Q170Q|FOXP2_ENST00000393498.2_Silent_p.Q150Q|FOXP2_ENST00000403559.4_Silent_p.Q187Q|FOXP2_ENST00000393494.2_Silent_p.Q170Q|FOXP2_ENST00000408937.3_Silent_p.Q195Q|FOXP2_ENST00000378237.3_Silent_p.Q170Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000393489.3_Silent_p.Q78Q|FOXP2_ENST00000350908.4_Silent_p.Q170Q|FOXP2_ENST00000390668.3_Silent_p.Q194Q|FOXP2_ENST00000393491.3_Silent_p.Q78Q			O15409	FOXP2_HUMAN	forkhead box P2	170	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q195Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						agcagcagcaacaacaacaac	0.502000													5	194					0	0	1	0	0
HERC2P3	0	broad.mit.edu	37	15	20644850	20644850	+	RNA	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr15:20644850G>A	ENST00000428453.1	-	0	3097																		p.A803V(4)		central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CATGTCCCTCGCCCTTTCGGT	0.463000													4	160					0	0	1	0	0
HNRNPF	3185	broad.mit.edu	37	10	43883011	43883011	+	Missense_Mutation	SNP	C	C	T			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr10:43883011C>T	ENST00000443950.2	-	3	808	c.322G>A	c.(322-324)Gcc>Acc	p.A108T	HNRNPF_ENST00000357065.4_Missense_Mutation_p.A108T|HNRNPF_ENST00000356053.3_Missense_Mutation_p.A108T|HNRNPF_ENST00000337970.3_Missense_Mutation_p.A108T|HNRNPF_ENST00000544000.1_Missense_Mutation_p.A108T	NM_001098208.1	NP_001091678.1	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	108					regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|urinary_tract(1)	19						CCATCGTTGGCGCTGTCGGCA	0.522000													6	473					0	0	1	0	0
DHRS7	51635	broad.mit.edu	37	14	60620745	60620745	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr14:60620745G>A	ENST00000216500.5	-	4	780	c.325C>T	c.(325-327)Ccc>Tcc	p.P109S	DHRS7_ENST00000536410.2_Missense_Mutation_p.P59S|PCNXL4_ENST00000406949.1_Intron|PCNXL4_ENST00000553898.1_Intron|DHRS7_ENST00000557185.1_Missense_Mutation_p.P109S			Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	109							binding|oxidoreductase activity			endometrium(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	5				OV - Ovarian serous cystadenocarcinoma(108;0.121)		AGGTCAAGGGGCAAAACAAGT	0.398000													5	293					0	0	1	0	0
RAMP3	10268	broad.mit.edu	37	7	45222927	45222927	+	Silent	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr7:45222927G>A	ENST00000242249.4	+	3	401	c.363G>A	c.(361-363)ccG>ccA	p.P121P	RAMP3_ENST00000496212.1_Silent_p.P121P|RAMP3_ENST00000481345.1_Silent_p.P121P	NM_005856.2	NP_005847.1	O60896	RAMP3_HUMAN	receptor (G protein-coupled) activity modifying protein 3	121					intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane|lysosome	protein transporter activity			breast(1)|endometrium(1)|large_intestine(4)|lung(4)|stomach(1)	11					Pramlintide(DB01278)	TTCTCATCCCGCTGATCGTTA	0.622000													11	636					0	0	1	0	0
ASH2L	9070	broad.mit.edu	37	8	37978568	37978568	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr8:37978568G>A	ENST00000343823.6	+	10	1375	c.1066G>A	c.(1066-1068)Gag>Aag	p.E356K	ASH2L_ENST00000521652.1_Missense_Mutation_p.E262K|ASH2L_ENST00000428278.2_Missense_Mutation_p.E262K|ASH2L_ENST00000545394.1_Missense_Mutation_p.E217K|ASH2L_ENST00000250635.7_Missense_Mutation_p.E262K	NM_004674.4	NP_004665.2	Q9UBL3	ASH2L_HUMAN	ash2 (absent, small, or homeotic)-like (Drosophila)	356					hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|stomach(1)	19	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				CCCTGACCCCGAGAAGCTGGA	0.532000											OREG0018719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	428					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46807563	46807563	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr22:46807563G>A	ENST00000262738.3	-	6	4704	c.4705C>T	c.(4705-4707)Cgc>Tgc	p.R1569C		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1569	Laminin G-like 1.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TTTCCAAAGCGCACAGCCATG	0.617000													5	309					0	0	1	0	0
PDCL3	79031	broad.mit.edu	37	2	101188240	101188240	+	Missense_Mutation	SNP	G	G	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr2:101188240G>A	ENST00000264254.6	+	5	935	c.557G>A	c.(556-558)gGc>gAc	p.G186D		NM_024065.4	NP_076970.1	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	186					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding			endometrium(3)|large_intestine(2)|liver(1)|lung(6)	12						GTGTTTGGCGGCATGAACCTG	0.498000													6	630					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44071946	44071948	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr1:44071946_44071948delGCG	ENST00000359947.4	+	20	3859_3861	c.3519_3521delGCG	c.(3517-3522)cag>ca	p.QR1173del	PTPRF_ENST00000422171.2_In_Frame_Del_p.QR521del|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000438120.1_In_Frame_Del_p.QR1164del|PTPRF_ENST00000372413.3_In_Frame_Del_p.QR1164del|PTPRF_ENST00000372414.3_In_Frame_Del_p.QR1173del	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1173					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAGAGGAGCAGCGGCGGCGGCGG	0.631													10	564	---	---	---	---					
ZCCHC11	23318	broad.mit.edu	37	1	52991403	52991403	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr1:52991403delT	ENST00000371544.3	-	2	812	c.550delA	c.(550-552)ttfs	p.I184fs	ZCCHC11_ENST00000371541.1_5'UTR|ZCCHC11_ENST00000257177.4_Frame_Shift_Del_p.I184fs|ZCCHC11_ENST00000355809.4_Frame_Shift_Del_p.I184fs	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	184					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						GAGCTTGGAATTTTTTTTCCA	0.408													7	1193	---	---	---	---					
NDC1	55706	broad.mit.edu	37	1	54298190	54298192	+	In_Frame_Del	DEL	TTA	TTA	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr1:54298190_54298192delTTA	ENST00000371429.3	-	3	849_851	c.251_253delTAA	c.(250-255)agt>a	p.IS84del	NDC1_ENST00000480952.1_5'UTR|NDC1_ENST00000234725.8_5'UTR|NDC1_ENST00000540001.1_In_Frame_Del_p.IS84del|NDC1_ENST00000537333.1_5'UTR	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin																		TTGAAAATACTTATTATTATTAT	0.305													8	205	---	---	---	---					
KIAA1324	57535	broad.mit.edu	37	1	109727724	109727725	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr1:109727724_109727725delAC	ENST00000369939.3	+	8	1193_1194	c.1010_1011delAC	c.(1009-1011)tfs	p.Y337fs	KIAA1324_ENST00000529753.1_Intron	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	337					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane		p.T340fs*21(1)		NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GATTATTTCTACACACACACGG	0.490													7	756	---	---	---	---					
PMF1	11243	broad.mit.edu	37	1	156182850	156182850	+	Frame_Shift_Del	DEL	A	A	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr1:156182850delA	ENST00000368277.3	+	1	53	c.44delA	c.(43-45)gafs	p.E15fs	PMF1-BGLAP_ENST00000368276.4_Frame_Shift_Del_p.E15fs|PMF1_ENST00000567140.1_Frame_Shift_Del_p.E15fs|PMF1-BGLAP_ENST00000490491.1_Frame_Shift_Del_p.E15fs|PMF1_ENST00000466489.1_3'UTR|PMF1_ENST00000368279.3_Frame_Shift_Del_p.E15fs|PMF1_ENST00000368273.4_Frame_Shift_Del_p.E15fs|PMF1_ENST00000565805.1_Frame_Shift_Del_p.E15fs|PMF1-BGLAP_ENST00000320139.5_Frame_Shift_Del_p.E15fs	NM_007221.3	NP_009152.2			polyamine-modulated factor 1											kidney(1)|large_intestine(2)|lung(3)	6	Hepatocellular(266;0.158)					GGCTGTGAGGAAAAAAGGCAT	0.572													7	344	---	---	---	---					
ZC3H11A	9877	broad.mit.edu	37	1	203819140	203819140	+	Frame_Shift_Del	DEL	A	A	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr1:203819140delA	ENST00000545588.1	+	14	5752	c.1925delA	c.(1924-1926)gafs	p.E642fs	ZC3H11A_ENST00000367210.1_Frame_Shift_Del_p.E642fs|ZC3H11A_ENST00000332127.4_Frame_Shift_Del_p.E642fs|ZC3H11A_ENST00000367214.1_Frame_Shift_Del_p.E642fs|ZC3H11A_ENST00000367212.3_Frame_Shift_Del_p.E642fs	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	642							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CAGACCTTGGAAAAAAGGGGT	0.418													7	409	---	---	---	---					
RQCD1	9125	broad.mit.edu	37	2	219447753	219447754	+	In_Frame_Ins	INS	-	-	ATT			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr2:219447753_219447754insATT	ENST00000273064.6	+	3	639_640	c.264_265insATT	c.(262-267)aagagt>aaATTgagt	p.88_89KS>KLS	RQCD1_ENST00000509807.2_In_Frame_Ins_p.88_89KS>KLS|RQCD1_ENST00000295701.5_In_Frame_Ins_p.88_89KS>KLS|RQCD1_ENST00000542068.1_In_Frame_Ins_p.88_89KS>KLS	NM_005444.2	NP_005435.1	Q92600	RCD1_HUMAN	RCD1 required for cell differentiation1 homolog (S. pombe)	88					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|sex differentiation|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding	p.N88K(1)		endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|prostate(3)|skin(1)	15		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000192)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACCAGTCTAACAGAGTTTGCAA	0.391													22	561	---	---	---	---					
NGEF	25791	broad.mit.edu	37	2	233785144	233785146	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr2:233785144_233785146delCTC	ENST00000264051.3	-	5	954_956	c.676_678delGAG	c.(676-678)del	p.E226del	NGEF_ENST00000373552.4_In_Frame_Del_p.E134del|NGEF_ENST00000409079.1_In_Frame_Del_p.E134del	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	226	Poly-Glu.|Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GGCTGGCCGGctcctcctcctcc	0.586													7	301	---	---	---	---					
WHSC1	7468	broad.mit.edu	37	4	1980558	1980559	+	Frame_Shift_Ins	INS	-	-	C			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr4:1980558_1980559insC	ENST00000382895.3	+	24	4451_4452	c.4020_4021insC	c.(4018-4023)aaccccfs	p.NP1340fs	WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000382888.3_Frame_Shift_Ins_p.NP688fs|WHSC1_ENST00000382891.5_Frame_Shift_Ins_p.NP1340fs|WHSC1_ENST00000382892.2_Frame_Shift_Ins_p.NP1340fs|WHSC1_ENST00000508803.1_Frame_Shift_Ins_p.NP1340fs	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	1340					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		AGACTGAGAAGCCCCCCCCAGA	0.678			T	IGH@	MM								7	165	---	---	---	---					
GABRG1	2565	broad.mit.edu	37	4	46060358	46060358	+	Frame_Shift_Del	DEL	A	A	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr4:46060358delA	ENST00000295452.4	-	7	959	c.792delT	c.(790-792)ttfs	p.F264fs		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	264					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity	p.F264fs*3(1)		breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TGCTCAGGTCAAAAAAAATTG	0.294													8	352	---	---	---	---					
PKD2	5311	broad.mit.edu	37	4	88986559	88986559	+	Frame_Shift_Del	DEL	A	A	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr4:88986559delA	ENST00000237596.2	+	11	2218	c.2152delA	c.(2152-2154)aafs	p.K719fs	PKD2_ENST00000511337.1_3'UTR|PKD2_ENST00000508588.1_Frame_Shift_Del_p.K137fs|PKD2_ENST00000502363.1_Frame_Shift_Del_p.K137fs	NM_000297.3	NP_000288.1	Q13563	PKD2_HUMAN	polycystic kidney disease 2 (autosomal dominant)	719	EF-hand domain.					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(2)|lung(15)|skin(4)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		ACTAAAACTGAAAAAAAATAC	0.383													8	592	---	---	---	---					
LRBA	987	broad.mit.edu	37	4	151223826	151223827	+	Frame_Shift_Ins	INS	-	-	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr4:151223826_151223827insA	ENST00000535741.1	-	53	8440_8441	c.7967_7968insT	c.(7966-7968)tctfs	p.S2656fs	LRBA_ENST00000503716.1_5'UTR|LRBA_ENST00000510413.1_Frame_Shift_Ins_p.S2656fs|LRBA_ENST00000357115.3_Frame_Shift_Ins_p.S2667fs			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2667						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					AATACCACAGCAAAAGAGTTGC	0.416													10	542	---	---	---	---					
AFF4	27125	broad.mit.edu	37	5	132232616	132232616	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr5:132232616delT	ENST00000265343.5	-	11	2085	c.1706delA	c.(1705-1707)agfs	p.K569fs	AFF4_ENST00000378595.3_Frame_Shift_Del_p.K569fs	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	569					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTTCTCAGCCTTTTTGGGTTG	0.507													7	560	---	---	---	---					
BTN2A3P	0	broad.mit.edu	37	6	26422388	26422390	+	RNA	DEL	CCT	CCT	-	rs113134648		TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr6:26422388_26422390delCCT	ENST00000466808.2	+	0	42_44																											GGCCAGCCTCCCTCCTCCTCCTC	0.586													13	442	---	---	---	---					
AK9	221264	broad.mit.edu	37	6	109980432	109980434	+	Splice_Site	DEL	TCT	TCT	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr6:109980432_109980434delTCT	ENST00000424296.2	-	7	703_705	c.630_splice	c.e7+1	p.EE209_splice	AK9_ENST00000341338.6_5'UTR|AK9_ENST00000285397.5_Splice_Site_p.EE209_splice|AK9_ENST00000368948.2_Splice_Site_p.EE209_splice	NM_001145128.2	NP_001138600.2			adenylate kinase 9																		AGATATTACCtcttcttcttctt	0.350													8	518	---	---	---	---					
IFNGR1	3459	broad.mit.edu	37	6	137519505	137519506	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr6:137519505_137519506delCT	ENST00000367739.4	-	7	1253_1254	c.1132_1133delAG	c.(1132-1134)tfs	p.S380fs	IFNGR1_ENST00000543628.1_Frame_Shift_Del_p.S352fs	NM_000416.2	NP_000407.1	P15260	INGR1_HUMAN	interferon gamma receptor 1	380					regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	18	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	AGGTGAAGAACTCTCTCTCTCT	0.431													8	517	---	---	---	---					
GRM1	2911	broad.mit.edu	37	6	146755219	146755221	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr6:146755219_146755221delGAG	ENST00000361719.2	+	9	3342_3344	c.2872_2874delGAG	c.(2872-2874)del	p.E961del	GRM1_ENST00000507907.1_3'UTR|GRM1_ENST00000282753.1_In_Frame_Del_p.E961del|GRM1_ENST00000492807.2_3'UTR|GRM1_ENST00000355289.4_3'UTR|GRM1_ENST00000392299.2_3'UTR	NM_001278064.1	NP_001264993.1	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	961					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TTACAACGTAGAGGAGGAGGAGG	0.586													7	826	---	---	---	---					
SCAF8	22828	broad.mit.edu	37	6	155153620	155153620	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr6:155153620delT	ENST00000367178.3	+	20	3483	c.2907delT	c.(2905-2907)ccfs	p.P969fs	SCAF8_ENST00000417268.1_Frame_Shift_Del_p.P969fs|SCAF8_ENST00000367186.4_Frame_Shift_Del_p.P1035fs	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	969	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						CCCGTGGACCTTTTCCTCCAG	0.473													9	1016	---	---	---	---					
MLLT4	4301	broad.mit.edu	37	6	168317900	168317900	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr6:168317900delT	ENST00000366806.2	+	19	2818	c.2676delT	c.(2674-2676)ccfs	p.P892fs	MLLT4_ENST00000351017.4_Frame_Shift_Del_p.P899fs|MLLT4_ENST00000447894.2_Frame_Shift_Del_p.P892fs|MLLT4_ENST00000344191.4_Frame_Shift_Del_p.P892fs|MLLT4_ENST00000392108.3_Frame_Shift_Del_p.P892fs|MLLT4_ENST00000392112.1_Frame_Shift_Del_p.P876fs|MLLT4_ENST00000400822.3_Frame_Shift_Del_p.P891fs			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	892	Dilute.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CTGATGAGCCTTTTATCCCAA	0.398			T	MLL	AL								7	791	---	---	---	---					
MPP6	51678	broad.mit.edu	37	7	24705665	24705666	+	Frame_Shift_Ins	INS	-	-	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr7:24705665_24705666insA	ENST00000396475.2	+	9	1208_1209	c.909_910insA	c.(907-912)agaaaafs	p.RK303fs	MPP6_ENST00000222644.4_Frame_Shift_Ins_p.RK303fs|MPP6_ENST00000409761.1_Frame_Shift_Ins_p.RK191fs	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	303					protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						CTATAAGTAGCAAAAAAAAGAA	0.302													7	840	---	---	---	---					
RP11-555J4.4	0	broad.mit.edu	37	9	32635706	32635706	+	RNA	DEL	T	T	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr9:32635706delT	ENST00000430787.1	+	0	1602																											CCCGCAAAACttttttttttt	0.542													2	4	---	---	---	---					
TPRN	286262	broad.mit.edu	37	9	140087025	140087027	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr9:140087025_140087027delTCC	ENST00000409012.4	-	2	1928_1930	c.1842_1844delGGA	c.(1840-1845)gaa>ga	p.EE620del	TPRN_ENST00000321773.2_In_Frame_Del_p.EE559del	NM_001128228.2	NP_001121700.2	Q4KMQ1	TPRN_HUMAN	taperin	620	Glu-rich.				sensory perception of sound	stereocilium		p.E315delE(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	8						ctcttcctcttcctcctcctcct	0.596													8	90	---	---	---	---					
SYT15	83849	broad.mit.edu	37	10	46969401	46969403	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr10:46969401_46969403delCAG	ENST00000374325.3	-	2	210_212	c.58_60delCTG	c.(58-60)del	p.L21del	SYT15_ENST00000374321.4_In_Frame_Del_p.L21del|SYT15_ENST00000503753.1_In_Frame_Del_p.L21del|SYT15_ENST00000374323.3_Intron	NM_181519.2	NP_852660.1	Q9BQS2	SYT15_HUMAN	synaptotagmin XV	21						integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						CCCCGATCAACAGCAGCAGCAGC	0.631													9	240	---	---	---	---					
DDX50	79009	broad.mit.edu	37	10	70666692	70666693	+	Frame_Shift_Ins	INS	-	-	A			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr10:70666692_70666693insA	ENST00000373585.3	+	2	420_421	c.313_314insA	c.(313-315)aaafs	p.K105fs		NM_024045.1	NP_076950.1	Q9BQ39	DDX50_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 50	105						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	29						AGATGAATATGAAAAAAAATCA	0.307													7	767	---	---	---	---					
TMEM254	80195	broad.mit.edu	37	10	81841638	81841639	+	Frame_Shift_Ins	INS	-	-	G			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr10:81841638_81841639insG	ENST00000372281.3	+	2	159_160	c.129_130insG	c.(127-132)ctggccfs	p.A44fs	TMEM254_ENST00000372274.1_Frame_Shift_Ins_p.A44fs|TMEM254_ENST00000467529.1_3'UTR|TMEM254_ENST00000372275.1_Frame_Shift_Ins_p.A44fs|TMEM254_ENST00000372277.3_Frame_Shift_Ins_p.A44fs	NM_001270372.1|NM_025125.3	NP_001257301.1|NP_079401.2			transmembrane protein 254																		ATCAGAACCTTGGGCCCCTGGG	0.505													8	696	---	---	---	---					
AGAP11	119385	broad.mit.edu	37	10	88764064	88764064	+	RNA	DEL	T	T	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr10:88764064delT	ENST00000444431.1	+	0	2623				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										TTGTTATGAATTTTTTTTCCT	0.378													7	826	---	---	---	---					
INA	9118	broad.mit.edu	37	10	105048271	105048273	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr10:105048271_105048273delGAG	ENST00000369849.4	+	3	1394_1396	c.1345_1347delGAG	c.(1345-1347)del	p.E454del		NM_032727.3	NP_116116.1	Q16352	AINX_HUMAN	internexin neuronal intermediate filament protein, alpha	454	Poly-Glu.|Tail.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton	p.E449_E450delEE(1)		breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)	13				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		ACTTAAGAAAGAGGAGGAGGAGG	0.458													18	450	---	---	---	---					
RAB11FIP2	22841	broad.mit.edu	37	10	119798647	119798647	+	Frame_Shift_Del	DEL	T	T	-	rs35192242		TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr10:119798647delT	ENST00000355624.3	-	3	1540	c.1101delA	c.(1099-1101)aafs	p.K367fs	RP11-354M20.3_ENST00000451610.2_RNA|RAB11FIP2_ENST00000369199.3_Frame_Shift_Del_p.K367fs	NM_014904.2	NP_055719.1	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2 (class I)	367					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(8)	19		Colorectal(252;0.235)		all cancers(201;0.0238)		TTCTGCTATCTTTTTTTCCAG	0.343													7	861	---	---	---	---					
KRTAP5-5	439915	broad.mit.edu	37	11	1651116	1651127	+	In_Frame_Del	DEL	GGCCGTGGCTCC	GGCCGTGGCTCC	-	rs66665994	by1000genomes	TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr11:1651116_1651127delGGCCGTGGCTCC	ENST00000399676.2	+	1	84_95	c.46_57delGGCCGTGGCTCC	c.(46-57)del	p.GRGS16del		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	16						keratin filament		p.R17C(2)|p.R17L(2)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		cggctgtggaggccgtggctccggctgtgggg	0.693													12	754	---	---	---	---					
SPON1	10418	broad.mit.edu	37	11	14101781	14101782	+	RNA	INS	-	-	T	rs72219431		TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr11:14101781_14101782insT	ENST00000310358.7	+	0	1211							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		TAttttttttcttttttttttt	0.441													3	6	---	---	---	---					
SPON1	10418	broad.mit.edu	37	11	14276276	14276277	+	RNA	DEL	GT	GT	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr11:14276276_14276277delGT	ENST00000310358.7	+	0	1627							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GACCTATGAGGTGTGTGTGTGT	0.594													14	251	---	---	---	---					
TMEM132A	54972	broad.mit.edu	37	11	60703785	60703787	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr11:60703785_60703787delGGA	ENST00000005286.4	+	11	2634_2636	c.2481_2483delGGA	c.(2479-2484)agg>ag	p.RE827del	TMEM132A_ENST00000453848.2_In_Frame_Del_p.RE826del	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	826	Binds to HSPA5/GRP78 (By similarity).|Confers cellular localization similar to full-length form (By similarity).|Glu-rich.					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						CCGAAGCCAGggaggaggaggag	0.635													7	422	---	---	---	---					
RTN3	10313	broad.mit.edu	37	11	63525788	63525788	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr11:63525788delT	ENST00000354497.4	+	4	634	c.570delT	c.(568-570)gcfs	p.A190fs	RTN3_ENST00000537981.1_3'UTR|RTN3_ENST00000341307.2_3'UTR|RTN3_ENST00000377819.5_3'UTR|RTN3_ENST00000540798.1_3'UTR|RTN3_ENST00000339997.4_3'UTR|RTN3_ENST00000356000.3_3'UTR	NM_001265591.1	NP_001252520.1	O95197	RTN3_HUMAN	reticulon 3	0					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						CATTCCAAGCTTTTTTTTTAA	0.348													9	319	---	---	---	---					
PPFIA1	8500	broad.mit.edu	37	11	70194407	70194407	+	Frame_Shift_Del	DEL	C	C	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr11:70194407delC	ENST00000253925.7	+	16	2259	c.2044delC	c.(2044-2046)ccfs	p.P683fs	PPFIA1_ENST00000389547.3_Frame_Shift_Del_p.P683fs|AP000487.6_ENST00000528607.1_RNA	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	683					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			GAGCTCCATTCCCCCCTACCC	0.557													7	1182	---	---	---	---					
DDX6	1656	broad.mit.edu	37	11	118629613	118629614	+	Splice_Site	INS	-	-	G			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr11:118629613_118629614insG	ENST00000264018.4	-	9	1170		c.e9-2		DDX6_ENST00000534980.1_Splice_Site|DDX6_ENST00000526070.2_Splice_Site	NM_004397.4	NP_004388.2	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 6						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	13	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		ATGGGAATTCTGGGGGGGGAGC	0.426			T	IGH@	B-NHL								11	627	---	---	---	---					
C1QTNF5	114902	broad.mit.edu	37	11	119210189	119210190	+	Frame_Shift_Ins	INS	-	-	C			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr11:119210189_119210190insC	ENST00000445041.2	-	15	3378_3379	c.583_584insG	c.(583-585)catfs	p.H195fs	C1QTNF5_ENST00000525657.1_5'UTR|C1QTNF5_ENST00000528368.1_Frame_Shift_Ins_p.H195fs|MFRP_ENST00000530681.1_3'UTR|MFRP_ENST00000555262.1_3'UTR	NM_001278431.1|NM_015645.3|NM_031433.2	NP_001265360.1|NP_056460.1|NP_113621.1	Q9BY79	MFRP_HUMAN	C1q and tumor necrosis factor related protein 5	147	CUB 1.				embryo development	integral to membrane				endometrium(1)|lung(2)	3		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		CCTCACCATGGCCCCCCCCGAG	0.589													7	326	---	---	---	---					
VPS29	51699	broad.mit.edu	37	12	110930880	110930881	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr12:110930880_110930881delTG	ENST00000549578.1	-	3	416_417	c.351_352delCA	c.(349-354)caaafs	p.HK117fs	VPS29_ENST00000546588.1_Frame_Shift_Del_p.HK149fs|VPS29_ENST00000447578.2_Frame_Shift_Del_p.HK22fs|VPS29_ENST00000549970.1_Frame_Shift_Del_p.HK22fs|VPS29_ENST00000552130.2_Frame_Shift_Del_p.HK22fs|VPS29_ENST00000360579.7_Frame_Shift_Del_p.HK121fs	NM_016226.3	NP_057310.1	Q9UBQ0	VPS29_HUMAN	vacuolar protein sorting 29 homolog (S. cerevisiae)	117					protein transport	endosome membrane	metal ion binding|phosphoserine phosphatase activity			kidney(1)|large_intestine(1)|lung(1)|prostate(1)	4						GCTTCAAATTTGTGTGTGTGTC	0.421													8	374	---	---	---	---					
TPCN1	53373	broad.mit.edu	37	12	113707611	113707613	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr12:113707611_113707613delCTG	ENST00000550785.1	+	8	1094_1096	c.925_927delCTG	c.(925-927)del	p.L312del	TPCN1_ENST00000541517.1_In_Frame_Del_p.L312del|TPCN1_ENST00000335509.6_In_Frame_Del_p.L240del|TPCN1_ENST00000392569.4_In_Frame_Del_p.L172del	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	240						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity	p.L237L(1)		cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						GGACATCCTCCTGCTGCTGCTGT	0.601													7	545	---	---	---	---					
RBM25	58517	broad.mit.edu	37	14	73574574	73574576	+	In_Frame_Del	DEL	ATG	ATG	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr14:73574574_73574576delATG	ENST00000261973.7	+	13	1793_1795	c.1508_1510delATG	c.(1507-1512)tat>t	p.YD503del	RBM25_ENST00000532483.1_3'UTR|RBM25_ENST00000527432.1_In_Frame_Del_p.YD503del	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	503	Arg-rich.|Glu-rich.|Necessary for nuclear speckle localization.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		TTAGAAGACTATGATGATGATAG	0.330													8	1265	---	---	---	---					
LRRC37A16P	0	broad.mit.edu	37	17	66141032	66141032	+	RNA	DEL	C	C	-	rs76883902	by1000genomes	TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr17:66141032delC	ENST00000590019.1	-	0	70																											AAAAAAAAAACATAAGCCAAA	0.338													10	373	---	---	---	---					
RP11-757O6.1	0	broad.mit.edu	37	18	14249254	14249254	+	RNA	DEL	A	A	-	rs71176025		TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr18:14249254delA	ENST00000580200.1	+	0	217																											GTTTAAACACAATTAGAATTA	0.303													4	5	---	---	---	---					
HAUS8	93323	broad.mit.edu	37	19	17160706	17160707	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr19:17160706_17160707delGA	ENST00000593360.1	-	10	3044_3045	c.1026_1027delTC	c.(1024-1029)tcgtfs	p.SR342fs	HAUS8_ENST00000448593.2_Frame_Shift_Del_p.SR402fs|HAUS8_ENST00000253669.5_Frame_Shift_Del_p.SR403fs			Q9BT25	HAUS8_HUMAN	HAUS augmin-like complex, subunit 8	403					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)	12						CTCCCTGAACGAGAGAGAGAGG	0.495													9	987	---	---	---	---					
ATP4A	495	broad.mit.edu	37	19	36054349	36054351	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr19:36054349_36054351delCTT	ENST00000262623.3	-	2	119_121	c.91_93delAAG	c.(91-93)del	p.K31del		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	31					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	CGCCACCCGCCTTCTTCTTCTTG	0.601													7	891	---	---	---	---					
AP001347.6	0	broad.mit.edu	37	21	15441192	15441193	+	RNA	INS	-	-	T	rs148464975		TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr21:15441192_15441193insT	ENST00000428809.1	+	0	177																											TGTATTTTGAATTCTTGGAATT	0.361													7	525	---	---	---	---					
LA16c-23H5.4	0	broad.mit.edu	37	22	16419352	16419352	+	RNA	DEL	T	T	-			TCGA-IB-AAUW-01A-12D-A38G-08	TCGA-IB-AAUW-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29cf030b-07b7-46ad-afb0-d7bde31ef55c	299dc91a-7da5-4537-adb8-646b7b5b75ca	g.chr22:16419352delT	ENST00000444162.1	+	0	279																											GAATCGACGATTTTTTTTTTG	0.398													9	30	---	---	---	---					
