Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PRAMEF11	440560	broad.mit.edu	37	1	12887453	12887453	+	Missense_Mutation	SNP	C	T	T	rs2486714	by1000genomes	TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr1:12887453C>T	uc001auk.2	-	2	600	c.404G>A	c.(403-405)aGa>aAa	p.R135K		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	Homo sapiens PRAME family member 11 (PRAMEF11), mRNA.	135										NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						TAGTAAATCTCTCCTCTGCTT	0.463000														11			5		0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134146968	134146968	+	Missense_Mutation	SNP	C	T	T			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr8:134146968C>T	uc003ytw.3	+	47	8278	c.8237C>T	c.(8236-8238)aCg>aTg	p.T2746M	TG_uc010mdw.3_Missense_Mutation_p.T1505M|TG_uc011ljb.2_Missense_Mutation_p.T1115M|TG_uc011ljc.2_Missense_Mutation_p.T879M	NM_003235	NP_003226	P01266	THYG_HUMAN	Homo sapiens thyroglobulin (TG), mRNA.	2746					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GAGGAGTTGACGGCTGGATCT	0.547000														20			9		0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108384832	108384832	+	Nonsense_Mutation	SNP	G	A	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr11:108384832G>A	uc001pkk.3	-	5	1513	c.1402C>T	c.(1402-1404)Cga>Tga	p.R468*	EXPH5_uc010rvz.2_Nonsense_Mutation_p.R312*|EXPH5_uc010rvy.2_Nonsense_Mutation_p.R280*	NM_015065	NP_055880	Q149M6	Q149M6_HUMAN	Homo sapiens exophilin 5 (EXPH5), mRNA.	468					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TCTCCGCTTCGTCCAAAGGTA	0.438000														62			45		0	0	1	0	0
TEAD4	7004	broad.mit.edu	37	12	3103971	3103971	+	Nonsense_Mutation	SNP	G	A	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr12:3103971G>A	uc010sej.2	+	2	331	c.39G>A	c.(37-39)tgG>tgA	p.W13*	TEAD4_uc010sek.2_Nonsense_Mutation_p.W13*|TEAD4_uc001qln.3_Intron	NM_201443	NP_958851	Q15561	TEAD4_HUMAN	Homo sapiens TEA domain family member 4 (TEAD4), transcript variant 3, mRNA.	13					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			CCAACGAGTGGAGCTCTCCCA	0.662000														38			36		0	0	1	0	0
HBS1L	10767	broad.mit.edu	37	6	135287507	135287507	+	Missense_Mutation	SNP	C	T	T			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr6:135287507C>T	uc003qez.2	-	16	2210	c.2003G>A	c.(2002-2004)cGt>cAt	p.R668H	HBS1L_uc003qey.2_Missense_Mutation_p.R504H|HBS1L_uc011ecy.1_Missense_Mutation_p.R392H|HBS1L_uc011ecz.1_Missense_Mutation_p.R504H|HBS1L_uc011eda.1_Missense_Mutation_p.R626H	NM_006620	NP_006611	Q9Y450	HBS1L_HUMAN	Homo sapiens HBS1-like (S. cerevisiae) (HBS1L), transcript variant 1, mRNA.	668					signal transduction		GTP binding|GTPase activity|translation elongation factor activity	p.R668P(2)|p.R668C(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	20	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)		ACCACCGTAACGTAGCATGAA	0.378000														34			41		0	0	1	0	0
TGM1	7051	broad.mit.edu	37	14	24723923	24723923	+	Missense_Mutation	SNP	C	T	T			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr14:24723923C>T	uc001wod.3	-	12	2159	c.2035G>A	c.(2035-2037)Gtg>Atg	p.V679M	TGM1_uc010tog.2_Missense_Mutation_p.V237M	NM_000359	NP_000350	P22735	TGM1_HUMAN	Homo sapiens transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) (TGM1), mRNA.	679					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)	24				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TTGGCCAGCACCTGCCCGCTC	0.617000														42			17		0	0	1	0	0
AFTPH	54812	broad.mit.edu	37	2	64778732	64778732	+	Missense_Mutation	SNP	G	A	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr2:64778732G>A	uc002sdc.3	+	0	156	c.124G>A	c.(124-126)Gta>Ata	p.V42I	AFTPH_uc002scz.3_Missense_Mutation_p.V42I|AFTPH_uc002sda.3_Missense_Mutation_p.V42I|AFTPH_uc002sdb.3_Missense_Mutation_p.V42I	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	Homo sapiens aftiphilin (AFTPH), transcript variant 1, mRNA.	42					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						CCCTTCTGGTGTAGGGTTTGT	0.408000														116			5		0	0	1	0	0
GPR97	222487	broad.mit.edu	37	16	57719755	57719755	+	Missense_Mutation	SNP	T	G	G			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr16:57719755T>G	uc002emh.3	+	10	1560	c.1457T>G	c.(1456-1458)gTg>gGg	p.V486G	GPR97_uc010vhv.2_Missense_Mutation_p.V366G|GPR97_uc010cdd.3_Non-coding_Transcript|GPR97_uc010cde.3_Missense_Mutation_p.V94G	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	Homo sapiens G protein-coupled receptor 97 (GPR97), mRNA.	486					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TCGAGCCTGGTGGGTGTGACA	0.602000														33			27		0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73040894	73040894	+	RNA	SNP	T	G	G			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chrX:73040894T>G	uc004ebn.2	+	0		c.28855T>G			XIST_uc004ebm.1_Non-coding_Transcript					Homo sapiens TSIX transcript, XIST antisense RNA (non-protein coding) (TSIX), antisense RNA.																		AGTTACTTTCTTCTTTCCATT	0.368000														10			21		0	0	1	0	0
AMELX	265	broad.mit.edu	37	X	11316686	11316686	+	Missense_Mutation	SNP	G	C	C			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chrX:11316686G>C	uc004cus.3	+	5	273	c.205G>C	c.(205-207)Gag>Cag	p.E69Q	ARHGAP6_uc004cup.1_Intron|ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc011mif.1_Intron|AMELX_uc004cut.3_Missense_Mutation_p.E55Q|AMELX_uc004cuu.3_Missense_Mutation_p.E39Q	NM_182680	NP_872621	Q99217	AMELX_HUMAN	Homo sapiens amelogenin, X-linked (AMELX), transcript variant 3, mRNA.	55					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel			endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	15						CTATGGTTACGAGCCCATGGG	0.547000														53			56		0	0	1	0	0
CYP21A1P	1590	broad.mit.edu	37	6	31974158	31974158	+	Missense_Mutation	SNP	A	G	G			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr6:31974158A>G	uc021yve.1	+	0	800	c.238A>G	c.(238-240)Aga>Gga	p.R80G	CYP21A2_uc021yvd.1_Missense_Mutation_p.K103R			Q5ST44	Q5ST44_HUMAN	Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene (CYP21A1P), non-coding RNA.	0							electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen										CTGGTGTCTAAGAACTACCCG	0.607000														15			3		0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114123222	114123222	+	Silent	SNP	C	T	T	rs141978579	byFrequency	TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr1:114123222C>T	uc001edk.3	+	2	673	c.492C>T	c.(490-492)tcC>tcT	p.S164S	MAGI3_uc001edh.3_Silent_p.S164S|MAGI3_uc001edi.4_Silent_p.S164S|MAGI3_uc010owm.2_Silent_p.S164S	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3), transcript variant 1, mRNA.	164	Guanylate kinase-like.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATTTCATTTCCGTTGAACAGT	0.393000														72			9		0	0	1	0	0
OR9I1	219954	broad.mit.edu	37	11	57886445	57886445	+	Silent	SNP	G	A	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr11:57886445G>A	uc001nml.1	-	0	472	c.472C>T	c.(472-474)Ctg>Ttg	p.L158L	OR9Q1_uc001nmj.3_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	Homo sapiens olfactory receptor, family 9, subfamily I, member 1 (OR9I1), mRNA.	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				GTGGTACGCAGGATGGCTCCT	0.547000														20			15		0	0	1	0	0
STAP1	26228	broad.mit.edu	37	4	68424566	68424566	+	Silent	SNP	G	A	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr4:68424566G>A	uc003hde.4	+	0	121	c.39G>A	c.(37-39)agG>agA	p.R13R	STAP1_uc003hdf.3_Silent_p.R13R	NM_012108	NP_036240	Q9ULZ2	STAP1_HUMAN	Homo sapiens signal transducing adaptor family member 1 (STAP1), mRNA.	13					cellular membrane fusion|intracellular protein transport	cytoplasm				NS(1)|large_intestine(1)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	12						CCCCTCGCAGGATCTTCCAGG	0.428000														42			42		0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153583052	153583052	+	Nonsense_Mutation	SNP	G	A	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chrX:153583052G>A	uc004fkk.2	-	31	5494	c.5245C>T	c.(5245-5247)Cag>Tag	p.Q1749*	FLNA_uc011mzn.1_5'UTR|FLNA_uc010nuu.1_Nonsense_Mutation_p.Q1741*	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	Homo sapiens filamin A, alpha (FLNA), transcript variant 2, mRNA.	1749	Hinge 1.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	Fc-gamma receptor I complex binding|GTP-Ral binding|Rac GTPase binding|actin filament binding|glycoprotein binding|protein homodimerization activity|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGAGGGGGCTGCACCGAGGGC	0.677000														14			3		0	0	1	0	0
X97876	0	broad.mit.edu	37	9	66500810	66500810	+	RNA	SNP	G	A	A	rs142815546	by1000genomes	TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr9:66500810G>A	uc004aed.1	+	2		c.903G>A								Homo sapiens uncharacterized LOC442421 (LOC442421), non-coding RNA.																		ACCTACGGTCGGTTGTGTGCA	0.637000														20			5		0	0	1	0	0
NUDT22	84304	broad.mit.edu	37	11	63995065	63995065	+	Missense_Mutation	SNP	A	C	C			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr11:63995065A>C	uc001nyp.4	+	2	686	c.506A>C	c.(505-507)cAg>cCg	p.Q169P	TRPT1_uc010rnc.2_5'Flank|TRPT1_uc010rnd.2_5'Flank|TRPT1_uc001nyo.3_5'Flank|TRPT1_uc010rnf.2_5'Flank|TRPT1_uc010rne.2_5'Flank|TRPT1_uc001nyn.3_5'Flank|NUDT22_uc009ype.3_Missense_Mutation_p.Q169P|NUDT22_uc001nyq.4_Intron|NUDT22_uc010rng.2_Non-coding_Transcript|DNAJC4_uc001nys.3_5'Flank|DNAJC4_uc001nyt.3_5'Flank|DNAJC4_uc001nyu.3_5'Flank	NM_032344	NP_115720	Q9BRQ3	NUD22_HUMAN	Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 22 (NUDT22), transcript variant 1, mRNA.	169	Nudix hydrolase.						hydrolase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)	8						GGCAGCCCCCAGCACCAGGAC	0.617000														37			24		0	0	1	0	0
LOC100233156	100233156	broad.mit.edu	37	GL000218.1	40675	40675	+	Silent	SNP	G	A	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chrGL000218.1:40675G>A	uc011mfn.2	-	2	344	c.255C>T	c.(253-255)gaC>gaT	p.D85D	LOC100233156_uc003jah.2_Silent_p.D85D					Homo sapiens tektin 4 pseudogene (LOC100233156), transcript variant 1, non-coding RNA.																		TGTGCCGCACGTCCTCCAGTT	0.662000														9			3		0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49735489	49735489	+	Silent	SNP	A	G	G			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr3:49735489A>G	uc003cxh.3	+	6	488	c.402A>G	c.(400-402)aaA>aaG	p.K134K	RNF123_uc010hky.1_5'Flank|RNF123_uc003cxi.3_5'Flank	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	Homo sapiens ring finger protein 123 (RNF123), mRNA.	134	B30.2/SPRY.					cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		TTCCAGGGAAATGGCTCTACG	0.582000														55			28		0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198267483	198267483	+	Missense_Mutation	SNP	C	T	T			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr2:198267483C>T	uc002uue.3	-	13	1922	c.1874G>A	c.(1873-1875)cGt>cAt	p.R625H		NM_012433	NP_036565	O75533	SF3B1_HUMAN	Homo sapiens splicing factor 3b, subunit 1, 155kDa (SF3B1), transcript variant 1, mRNA.	625					nuclear mRNA splicing, via spliceosome	U12-type spliceosomal complex|catalytic step 2 spliceosome|nuclear speck	protein binding	p.R625L(21)|p.R625?(9)|p.R625C(9)|p.R625P(4)|p.R625H(3)|p.R625G(1)		NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGTTGTGTTACGGACATACTC	0.438000			Mis		myelodysplastic syndrome									25			22		0	0	1	0	0
RALGDS	5900	broad.mit.edu	37	9	135984119	135984119	+	Missense_Mutation	SNP	C	T	T			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr9:135984119C>T	uc004cco.3	-	4	739	c.719G>A	c.(718-720)cGt>cAt	p.R240H	RALGDS_uc004ccp.3_Non-coding_Transcript|RALGDS_uc004ccq.3_Missense_Mutation_p.R228H|RALGDS_uc004ccr.3_Missense_Mutation_p.R239H|RALGDS_uc011mcv.2_Missense_Mutation_p.R211H|RALGDS_uc004ccs.3_Missense_Mutation_p.R185H|RALGDS_uc011mcw.2_Missense_Mutation_p.R311H|RALGDS_uc004ccv.1_Missense_Mutation_p.R9H|RALGDS_uc004ccu.1_Missense_Mutation_p.R9H	NM_006266	NP_006257	Q12967	GNDS_HUMAN	Homo sapiens ral guanine nucleotide dissociation stimulator (RALGDS), transcript variant 1, mRNA.	240	N-terminal Ras-GEF.				Ras protein signal transduction|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		AAGGTGGGCACGGCGCTCCAG	0.622000			T	CIITA	"""PMBL, Hodgkin Lymphona, """									51			3		0	0	1	0	0
GNAQ	2776	broad.mit.edu	37	9	80409488	80409488	+	Missense_Mutation	SNP	T	G	G	rs121913492		TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr9:80409488T>G	uc004akw.3	-	4	694	c.626A>C	c.(625-627)cAa>cCa	p.Q209P	GNAQ_uc011lso.2_Missense_Mutation_p.Q7P	NM_002072	NP_002063	P50148	GNAQ_HUMAN	Homo sapiens guanine nucleotide binding protein (G protein), q polypeptide (GNAQ), mRNA.	209					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity	p.Q209L(208)|p.Q209P(206)|p.Q209R(4)|p.Q209Y(2)|p.Q209H(1)|p.Q209K(1)		NS(1)|endometrium(3)|eye(229)|kidney(1)|large_intestine(4)|lung(6)|meninges(11)|ovary(1)|prostate(1)|skin(44)|upper_aerodigestive_tract(1)	302						CTCTGACCTTTGGCCCCCTAC	0.348000			Mis		uveal melanoma									20			17		0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77472300	77472300	+	Frame_Shift_Del	DEL	T	-	-			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr15:77472300delT	uc021sqy.1	-	4	2545	c.1969delA	c.(1969-1971)accfs	p.T657fs	PEAK1_uc002bcn.2_Frame_Shift_Del_p.T657fs|PEAK1_uc021sqz.1_Frame_Shift_Del_p.T55fs	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	Homo sapiens NKF3 kinase family member (PEAK1), mRNA.	657					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										ACACTTGTGGTTTTTTCCTTC	0.363													---	72	---	---	31	---					
