Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MEGF6	1953	broad.mit.edu	37	1	3418372	3418372	+	Missense_Mutation	SNP	C	C	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:3418372C>A	ENST00000356575.4	-	18	2528	c.2302G>T	c.(2302-2304)Gac>Tac	p.D768Y	MEGF6_ENST00000294599.4_Missense_Mutation_p.D663Y	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	768	EGF-like 12.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCCTCACAGTCTTCCCCAGTC	0.711000													12	22					6.40141e-05	6.90348e-05	1	1	0
KIF2B	84643	broad.mit.edu	37	17	51901710	51901710	+	Missense_Mutation	SNP	T	T	G			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:51901710T>G	ENST00000268919.4	+	1	1472	c.1316T>G	c.(1315-1317)aTg>aGg	p.M439R		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	439	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GGACGGATAATGCATGGCAAG	0.507000													10	42					0	0	1	0	0
OR10A6	390093	broad.mit.edu	37	11	7950117	7950117	+	Silent	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr11:7950117G>A	ENST00000309838.2	-	1	92	c.93C>T	c.(91-93)ttC>ttT	p.F31F		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AAATAACCAGGAAAGCCACAA	0.448000													86	26					0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45390466	45390466	+	Silent	SNP	A	A	G			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr6:45390466A>G	ENST00000371438.1	+	2	553	c.195A>G	c.(193-195)caA>caG	p.Q65Q	RUNX2_ENST00000352853.5_Silent_p.Q133Q|RUNX2_ENST00000541979.1_Silent_p.Q133Q|RUNX2_ENST00000465038.2_Silent_p.Q65Q|RUNX2_ENST00000576263.1_Silent_p.Q65Q|RUNX2_ENST00000371432.3_Silent_p.Q51Q|RUNX2_ENST00000371436.6_Silent_p.Q65Q|RUNX2_ENST00000359524.5_Silent_p.Q51Q	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	65	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						agcagcagcaacagcagcagc	0.731000													3	36					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81657012	81657012	+	Missense_Mutation	SNP	T	T	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:81657012T>A	ENST00000550584.2	-	30	4008	c.3713A>T	c.(3712-3714)gAt>gTt	p.D1238V	PPFIA2_ENST00000548586.1_Missense_Mutation_p.D1232V|PPFIA2_ENST00000541570.2_Missense_Mutation_p.D774V|PPFIA2_ENST00000549396.1_Missense_Mutation_p.D1238V|PPFIA2_ENST00000550359.2_Missense_Mutation_p.D1085V|PPFIA2_ENST00000443686.3_Missense_Mutation_p.D1133V|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000541017.1_Missense_Mutation_p.D424V|PPFIA2_ENST00000407050.4_Missense_Mutation_p.D1137V|PPFIA2_ENST00000552948.1_Missense_Mutation_p.D1217V|PPFIA2_ENST00000333447.7_Missense_Mutation_p.D1226V|PPFIA2_ENST00000549325.1_Missense_Mutation_p.D1223V	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	1137										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TACTGTACCATCTGTTGTCAT	0.398000													3	5					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7751444	7751444	+	Missense_Mutation	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:7751444C>T	ENST00000254846.5	+	11	2227	c.1838C>T	c.(1837-1839)tCc>tTc	p.S613F	KDM6B_ENST00000448097.2_Missense_Mutation_p.S613F	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	613	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						CCTCCTTCCTCCTGCCACCAA	0.677000													5	89					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54914489	54914489	+	Missense_Mutation	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:54914489G>A	ENST00000293373.6	+	17	1716	c.1637G>A	c.(1636-1638)cGt>cAt	p.R546H	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.R496H	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	546					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TTTCATCTTCGTATCTTTGAG	0.393000													35	75					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	C	T	rs28934576	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:7577120C>T	ENST00000420246.2	-	8	950	c.818G>A	c.(817-819)cGt>cAt	p.R273H	TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.R273H|TP53_ENST00000445888.2_Missense_Mutation_p.R273H|TP53_ENST00000269305.4_Missense_Mutation_p.R273H|TP53_ENST00000359597.4_Missense_Mutation_p.R273H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	273	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; abolishes sequence-specific DNA binding; dbSNP:rs28934576).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(521)|p.R273L(93)|p.R273P(32)|p.0?(8)|p.?(2)|p.R273fs*32(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273S(1)|p.E258fs*71(1)|p.R273fs*72(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.R273fs*33(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542000	R273H(EN_ENDOMETRIUM)|R273H(HEC59_ENDOMETRIUM)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(MDAMB468_BREAST)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(NCIH1155_LUNG)|R273H(NCIH1793_LUNG)|R273H(NCIH1975_LUNG)|R273H(NCIH2405_LUNG)|R273H(NCIH508_LARGE_INTESTINE)|R273H(OC314_OVARY)|R273H(PANC1_PANCREAS)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SKMEL30_SKIN)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SUIT2_PANCREAS)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(SW480_LARGE_INTESTINE)|R273H(SW620_LARGE_INTESTINE)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	8					0	0	1	0	0
RHCG	51458	broad.mit.edu	37	15	90023572	90023572	+	Missense_Mutation	SNP	C	C	T	rs149510924	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr15:90023572C>T	ENST00000268122.4	-	4	658	c.590G>A	c.(589-591)cGg>cAg	p.R197Q	RHCG_ENST00000544600.1_Missense_Mutation_p.R197Q	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	197					amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding	p.R197L(1)|p.R197Q(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					GTAGAGGATCCGGGTCACTGT	0.557000													56	26					0	0	1	0	0
LHFP	10186	broad.mit.edu	37	13	40175117	40175117	+	Silent	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr13:40175117G>A	ENST00000379589.3	-	2	699	c.237C>T	c.(235-237)agC>agT	p.S79S		NM_005780.2	NP_005771.1	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner	79						integral to membrane	DNA binding		HMGA2/LHFP(2)	breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(6)|prostate(2)	13		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		TCCATTCTGCGCTGGGGATGC	0.597000			T	HMGA2	lipoma								144	47					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143996607	143996607	+	Silent	SNP	C	C	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr8:143996607C>A	ENST00000323110.2	-	3	452	c.450G>T	c.(448-450)tcG>tcT	p.S150S		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	150					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CGGCCTTGGGCGACAGCACAT	0.637000									Familial Hyperaldosteronism type I				7	71					8.12818e-05	8.68059e-05	1	1	0
HIVEP2	3097	broad.mit.edu	37	6	143091566	143091566	+	Missense_Mutation	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr6:143091566C>T	ENST00000367603.2	-	5	5052	c.4310G>A	c.(4309-4311)gGt>gAt	p.G1437D	HIVEP2_ENST00000367604.1_Missense_Mutation_p.G1437D|HIVEP2_ENST00000012134.2_Missense_Mutation_p.G1437D	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TCGCTTGCTACCTCCCAGGGT	0.512000													26	33					0	0	1	0	0
KIAA1045	23349	broad.mit.edu	37	9	34978096	34978096	+	Silent	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr9:34978096G>A	ENST00000242315.3	+	8	1273	c.1191G>A	c.(1189-1191)aaG>aaA	p.K397K	KIAA1045_ENST00000476115.2_3'UTR|KIAA1045_ENST00000544237.1_Silent_p.K397K	NM_015297.1	NP_056112.1	Q9UPV7	K1045_HUMAN	KIAA1045	397							calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(32;0.00575)			TTCACCTGAAGCCCCCAGGAT	0.557000													14	78					0	0	1	0	0
SS18L1	26039	broad.mit.edu	37	20	60736500	60736500	+	Silent	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr20:60736500G>A	ENST00000331758.3	+	4	266	c.240G>A	c.(238-240)acG>acA	p.T80T	SS18L1_ENST00000421564.1_Silent_p.T80T|SS18L1_ENST00000370848.4_Silent_p.T83T	NM_198935.1	NP_945173.1	O75177	CREST_HUMAN	synovial sarcoma translocation gene on chromosome 18-like 1	80	N-terminal auto-inhibitory domain; necessary for interaction with SMARCA4/BRG1 (By similarity).				chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome kinetochore			SS18L1/SSX1(2)	ovary(2)|skin(1)	3	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.92e-08)			AGCCGCCCACGCAGAACATGA	0.622000			T	SSX1	synovial sarcoma								27	52					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803562	142803562	+	RNA	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:142803562G>A	ENST00000423385.1	-	0	1403																											TCTGCAGTCAGGTAAGATTTC	0.259000													5	158					0	0	1	0	0
SHOX	6473	broad.mit.edu	37	X	601571	601571	+	Silent	SNP	C	C	A	rs137852557		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chrX:601571C>A	ENST00000381578.1	+	4	1193	c.502C>A	c.(502-504)Cgg>Agg	p.R168R	SHOX_ENST00000334060.3_Silent_p.R168R|SHOX_ENST00000554971.1_Silent_p.R168R|SHOX_ENST00000381575.1_Silent_p.R168R	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	168			R -> W (in LMD).		skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTTCCAGAACCGGAGAGCCAA	0.592000													5	74					0.0215528	0.0217505	1	1	0
BTNL2	56244	broad.mit.edu	37	6	32362585	32362585	+	Missense_Mutation	SNP	G	G	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr6:32362585G>T	ENST00000454136.3	-	6	1300	c.1296C>A	c.(1294-1296)gaC>gaA	p.D432E	BTNL2_ENST00000374993.1_Missense_Mutation_p.D432E|BTNL2_ENST00000414363.1_Missense_Mutation_p.D222E|BTNL2_ENST00000429232.2_3'UTR|BTNL2_ENST00000544175.1_Missense_Mutation_p.D155E|BTNL2_ENST00000540315.1_Missense_Mutation_p.D222E|BTNL2_ENST00000374995.3_Missense_Mutation_p.D338E			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	432						integral to membrane		p.D432D(1)		central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						AACAAGTGACGTCCACAGCGG	0.498000													14	78					7.93312e-07	8.81458e-07	1	1	0
LNPEP	4012	broad.mit.edu	37	5	96360368	96360368	+	Missense_Mutation	SNP	A	A	G			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:96360368A>G	ENST00000231368.5	+	15	3397	c.2705A>G	c.(2704-2706)gAt>gGt	p.D902G	LNPEP_ENST00000395770.3_Missense_Mutation_p.D888G	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	902					cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		AGCTCAGAGGATGTGCGGAAG	0.408000													11	20					0	0	1	0	0
SGSH	6448	broad.mit.edu	37	17	78184304	78184304	+	Missense_Mutation	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:78184304C>T	ENST00000326317.6	-	8	1542	c.1456G>A	c.(1456-1458)Gtc>Atc	p.V486I	SGSH_ENST00000534910.1_Missense_Mutation_p.V283I	NM_000199.3	NP_000190.1	P51688	SPHM_HUMAN	N-sulfoglucosamine sulfohydrolase	486			V -> F (in MPS3A).		proteoglycan metabolic process	lysosome	metal ion binding|N-sulfoglucosamine sulfohydrolase activity|sulfuric ester hydrolase activity			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TCCTCCAGGACGCCGTCGGGG	0.652000													5	15					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47847228	47847228	+	Missense_Mutation	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr6:47847228C>T	ENST00000339488.4	-	3	1385	c.1352G>A	c.(1351-1353)cGt>cAt	p.R451H		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	451						integral to membrane	hedgehog receptor activity										ATAATGTTCACGGAGGAAGTG	0.448000													12	30					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	667810	667810	+	Missense_Mutation	SNP	C	C	G			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:667810C>G	ENST00000266383.5	+	18	2757	c.2744C>G	c.(2743-2745)aCc>aGc	p.T915S		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	915						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			TGTGGGGCCACCCCCCAGTGG	0.567000													9	30					0	0	1	0	0
ANXA10	11199	broad.mit.edu	37	4	169049237	169049237	+	Silent	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr4:169049237G>A	ENST00000359299.3	+	2	207	c.21G>A	c.(19-21)gtG>gtA	p.V7V		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	7							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		CCCACCAGGTGCAAGGAACCA	0.433000													10	15					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57193840	57193840	+	Missense_Mutation	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr4:57193840C>T	ENST00000504228.1	+	9	3677	c.3572C>T	c.(3571-3573)cCg>cTg	p.P1191L	KIAA1211_ENST00000541073.1_Missense_Mutation_p.P1184L|KIAA1211_ENST00000264229.6_Missense_Mutation_p.P1191L			Q6ZU35	K1211_HUMAN	KIAA1211	1191										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CCCCCAGCGCCGCTGGTAAAA	0.483000													61	76					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55277787	55277787	+	Silent	SNP	C	C	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:55277787C>A	ENST00000358193.3	+	6	741	c.687C>A	c.(685-687)gtC>gtA	p.V229V	C1orf177_ENST00000371273.3_Silent_p.V229V	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	229										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						CACGATCCGTCGGCACCCGCG	0.587000													20	67					5.03518e-11	5.76948e-11	1	1	0
OR5D14	219436	broad.mit.edu	37	11	55563417	55563417	+	Missense_Mutation	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr11:55563417G>A	ENST00000335605.1	+	1	386	c.386G>A	c.(385-387)tGc>tAc	p.C129Y		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				GTGGCCATCTGCAATCCTCTG	0.532000													7	50					0	0	1	0	0
KDELR2	0	broad.mit.edu	37	7	6509337	6509337	+	Missense_Mutation	SNP	T	T	G			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr7:6509337T>G	ENST00000258739.4	-	3	425	c.241A>C	c.(241-243)Aaa>Caa	p.K81Q	KDELR2_ENST00000490996.1_Missense_Mutation_p.K81Q|DAGLB_ENST00000436575.1_Intron|KDELR2_ENST00000463747.1_Intron	NM_006854.3	NP_006845.1	P33947	ERD22_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	81					intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	KDEL sequence binding|protein binding|receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)	10		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		GCCTTAAATTTCAGGTAGATC	0.443000													21	66					0	0	1	0	0
SERPINB9	5272	broad.mit.edu	37	6	2893765	2893765	+	Silent	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr6:2893765C>T	ENST00000380698.4	-	5	536	c.447G>A	c.(445-447)ccG>ccA	p.P149P		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	149					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TTGAGCTACCCGGCAACAACT	0.393000													39	13					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158152703	158152703	+	Missense_Mutation	SNP	C	C	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:158152703C>A	ENST00000368171.3	+	5	1142	c.643C>A	c.(643-645)Cct>Act	p.P215T		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	215	Ig-like.				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					TGGCCCCAGTCCTGGCCCTGG	0.592000													20	65					1.01871e-10	1.15524e-10	1	1	0
LRRC4B	94030	broad.mit.edu	37	19	51022478	51022478	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr19:51022478C>T	ENST00000599957.1	-	3	689	c.492G>A	c.(490-492)tgG>tgA	p.W164*	LRRC4B_ENST00000389201.3_Nonsense_Mutation_p.W164*			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	164						cell junction|integral to membrane|presynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		TGTTCCGCAGCCAGAGCTCCC	0.652000													40	53					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16742751	16742751	+	Silent	SNP	G	G	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr2:16742751G>T	ENST00000381323.3	-	7	706	c.486C>A	c.(484-486)atC>atA	p.I162I	FAM49A_ENST00000406434.1_Silent_p.I162I|FAM49A_ENST00000355549.2_Silent_p.I162I	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	162						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			GGTTGCGACTGATTGTTCTTC	0.493000													9	42					0.000978159	0.00100558	1	1	0
MT-RNR2	0	broad.mit.edu	37	MT	2113	2113	+	RNA	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chrM:2113G>A	ENST00000387347.2	+	0	443					NR_039705.1																						CAAAGAGGAACAGCTCTTTGG	0.383000													69	7					0	0	1	0	0
SLC43A1	8501	broad.mit.edu	37	11	57281459	57281459	+	Missense_Mutation	SNP	G	G	C			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr11:57281459G>C	ENST00000278426.3	-	2	481	c.126C>G	c.(124-126)aaC>aaG	p.N42K	SLC43A1_ENST00000528450.1_Missense_Mutation_p.N42K	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1	42					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						AGAAGCCCTCGTTCTTCAGAA	0.597000													19	3					0	0	1	0	0
NDUFAF2	91942	broad.mit.edu	37	5	60241050	60241050	+	Translation_Start_Site	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:60241050G>A	ENST00000296597.5	+	0	95				NDUFAF2_ENST00000511107.1_De_novo_Start_OutOfFrame	NM_174889.4	NP_777549.1	Q8N183	MIMIT_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2							membrane|mitochondrion	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|ovary(1)	6		Lung NSC(810;3.36e-05)|Prostate(74;0.0225)|Ovarian(174;0.17)|Breast(144;0.237)				TGCGGGTCCCGCTGCTGGCAG	0.632000													3	15					0	0	1	0	0
LARP4B	23185	broad.mit.edu	37	10	909780	909780	+	Silent	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:909780G>A	ENST00000316157.3	-	4	373	c.333C>T	c.(331-333)gcC>gcT	p.A111A		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	111							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						CTGGCAATGCGGCATTCTCAT	0.507000													49	48					0	0	1	0	0
PYY	5697	broad.mit.edu	37	17	42030806	42030806	+	Missense_Mutation	SNP	G	G	C			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:42030806G>C	ENST00000360085.2	-	5	586	c.46C>G	c.(46-48)Ctg>Gtg	p.L16V	PYY_ENST00000592796.1_Missense_Mutation_p.L16V	NM_004160.4	NP_004151.3	P10082	PYY_HUMAN	peptide YY	16					cell proliferation|cell-cell signaling|cellular component movement|cytoskeleton organization|digestion|G-protein coupled receptor protein signaling pathway	soluble fraction				endometrium(1)|ovary(1)	2		Breast(137;0.00314)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.12)		AGCAGGGCCAGAAGCACTGTG	0.662000													4	22					0	0	1	0	0
MPHOSPH9	10198	broad.mit.edu	37	12	123703047	123703047	+	Splice_Site	SNP	C	C	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:123703047C>A	ENST00000606320.1	-	6	1079		c.e6-1		MPHOSPH9_ENST00000541076.2_Splice_Site|MPHOSPH9_ENST00000302349.5_Splice_Site|MPHOSPH9_ENST00000392425.3_Splice_Site			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9						M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		TATAGCATTACTATTTAAGAA	0.398000													9	75					0.000673444	0.000698857	1	1	0
MARCH8	220972	broad.mit.edu	37	10	45954693	45954693	+	Missense_Mutation	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:45954693G>A	ENST00000453424.2	-	7	1553	c.1292C>T	c.(1291-1293)tCc>tTc	p.S431F	MARCH8_ENST00000395769.2_Missense_Mutation_p.S149F|MARCH8_ENST00000319836.3_Missense_Mutation_p.S149F|MARCH8_ENST00000395771.3_Missense_Mutation_p.S149F|MARCH8_ENST00000476962.1_5'UTR			Q5T0T0	MARH8_HUMAN	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	149						cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	12						GCGCTCGCTGGACGTCATCTG	0.532000													17	96					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129905831	129905831	+	Missense_Mutation	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:129905831C>T	ENST00000368654.3	-	13	4648	c.4273G>A	c.(4273-4275)Gga>Aga	p.G1425R	MKI67_ENST00000368653.3_Missense_Mutation_p.G1065R	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1425	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCCTCACCTCCTGGTACTTTA	0.478000													6	246					0	0	1	0	0
SYNE3	161176	broad.mit.edu	37	14	95921744	95921744	+	Silent	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr14:95921744G>A	ENST00000334258.5	-	5	1121	c.1107C>T	c.(1105-1107)gaC>gaT	p.D369D	SYNE3_ENST00000554873.1_Silent_p.D126D|SYNE3_ENST00000557275.1_Silent_p.D369D|SYNE3_ENST00000553340.1_Silent_p.D369D	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						CCACCAGCTCGTCCTCGGTCC	0.642000													8	29					0	0	1	0	0
AC226119.5	0	broad.mit.edu	37	4	3952899	3952899	+	RNA	SNP	A	A	T	rs17410906		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr4:3952899A>T	ENST00000281228.8	-	0	208				FAM86EP_ENST00000313946.8_RNA																							AGCACCGGGCATACTTGACTG	0.557000													4	51					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13608	13608	+	Silent	SNP	T	T	C			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chrM:13608T>C	ENST00000361567.2	+	1	1272	c.1272T>C	c.(1270-1272)acT>acC	p.T424T				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	424					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	GCCTATAGCACTCGAATAATT	0.463000													53	88					0	0	1	0	0
RDH14	57665	broad.mit.edu	37	2	18736500	18736500	+	Missense_Mutation	SNP	T	T	G			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr2:18736500T>G	ENST00000381249.3	-	2	1075	c.968A>C	c.(967-969)aAa>aCa	p.K323T	RDH14_ENST00000468071.1_5'UTR	NM_020905.3	NP_065956.1			retinol dehydrogenase 14 (all-trans/9-cis/11-cis)											breast(2)|endometrium(1)|large_intestine(2)|lung(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)					ATCCCAGAGTTTTCTTGCAAC	0.413000													33	71					0	0	1	0	0
HBA1	3039	broad.mit.edu	37	16	227404	227404	+	Nonsense_Mutation	SNP	C	C	A	rs121913128		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr16:227404C>A	ENST00000320868.5	+	3	460	c.423C>A	c.(421-423)taC>taA	p.Y141*	HBA1_ENST00000397797.1_Nonsense_Mutation_p.Y109*	NM_000558.3	NP_000549.1	P69905	HBA_HUMAN	hemoglobin, alpha 1	141			Y -> H (in Rouen/Ethiopia; O(2) affinity up).		hydrogen peroxide catabolic process|positive regulation of cell death|protein heterooligomerization	cytosolic small ribosomal subunit|haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity|protein binding			lung(1)	1		all_cancers(16;2.03e-06)|all_epithelial(16;5.16e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0138)|all_lung(18;0.0306)			Amodiaquine(DB00613)|Chloroquine(DB00608)|Iron Dextran(DB00893)|Mefloquine(DB00358)|Primaquine(DB01087)|Quinine(DB00468)	CCTCCAAATACCGTTAAGCTG	0.647000											OREG0003687	type=REGULATORY REGION|Gene=SERPINB9|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	5	17					0.000602214	0.000630891	1	1	0
GRXCR1	389207	broad.mit.edu	37	4	42895339	42895339	+	Missense_Mutation	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr4:42895339G>A	ENST00000399770.2	+	1	56	c.56G>A	c.(55-57)cGg>cAg	p.R19Q		NM_001080476.2	NP_001073945.1	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	19					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(22)|ovary(1)|prostate(2)|skin(1)	32						GTCCGGTTTCGGATCGCGTCC	0.512000													19	105					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110131681	110131681	+	Missense_Mutation	SNP	T	T	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr8:110131681T>A	ENST00000518632.1	+	3	1545	c.1194T>A	c.(1192-1194)agT>agA	p.S398R	TRHR_ENST00000311762.2_Missense_Mutation_p.S398R			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	398						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			TTAGCCAAAGTTGATTCATGA	0.403000													12	80					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35448925	35448925	+	Missense_Mutation	SNP	G	G	C			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr19:35448925G>C	ENST00000404801.1	-	4	2220	c.1834C>G	c.(1834-1836)Cag>Gag	p.Q612E	ZNF792_ENST00000605484.1_Missense_Mutation_p.Q545E	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	612					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			ACAGCGCCCTGATAAGGTCTG	0.488000													10	17					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3076369	3076369	+	Missense_Mutation	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr3:3076369G>A	ENST00000397461.1	+	16	2221	c.1837G>A	c.(1837-1839)Gct>Act	p.A613T	CNTN4_ENST00000427331.1_Missense_Mutation_p.A613T|CNTN4_ENST00000418658.1_Missense_Mutation_p.A613T|CNTN4_ENST00000397459.2_Missense_Mutation_p.A285T|CNTN4_ENST00000448906.2_Missense_Mutation_p.A285T|CNTN4_ENST00000358480.3_Missense_Mutation_p.A394T	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	613	Fibronectin type-III 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AGATACCACTGCTCAGCTCTC	0.552000													25	38					0	0	1	0	0
CPA4	51200	broad.mit.edu	37	7	129950692	129950692	+	Missense_Mutation	SNP	G	G	C			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr7:129950692G>C	ENST00000222482.4	+	9	887	c.859G>C	c.(859-861)Gag>Cag	p.E287Q	CPA4_ENST00000493259.1_Missense_Mutation_p.E183Q|CPA4_ENST00000445470.2_Missense_Mutation_p.E254Q	NM_016352.3	NP_057436.2	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4	287					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Melanoma(18;0.0435)					TTCGGAAGTGGAGGTGAAATC	0.493000													26	71					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292797	102292797	+	RNA	SNP	C	C	G			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr15:102292797C>G	ENST00000561463.1	+	0	843																		p.P129A(2)									GAGCTGCTGTCCAACCTGCAC	0.597000													3	37					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46847315	46847315	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:46847315G>A	ENST00000393382.3	-	14	2326	c.2185C>T	c.(2185-2187)Cag>Tag	p.Q729*	TTLL6_ENST00000433608.2_Nonsense_Mutation_p.Q422*	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	681						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						GGGGTCTGCTGCTTCTTGCAT	0.502000													11	105					0	0	1	0	0
SAMD4B	55095	broad.mit.edu	37	19	39868449	39868449	+	Missense_Mutation	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr19:39868449C>T	ENST00000314471.6	+	10	2464	c.1429C>T	c.(1429-1431)Cgg>Tgg	p.R477W	SAMD4B_ENST00000598913.1_Missense_Mutation_p.R477W|SAMD4B_ENST00000596368.1_Intron	NM_018028.2	NP_060498.2	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	477							protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(2)	15	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CCAGTTTACACGGGTGATGGG	0.592000													21	51					0	0	1	0	0
MTR	4548	broad.mit.edu	37	1	237016332	237016332	+	Missense_Mutation	SNP	G	G	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:237016332G>T	ENST00000366577.5	+	18	2291	c.1897G>T	c.(1897-1899)Gat>Tat	p.D633Y	MTR_ENST00000535889.1_Missense_Mutation_p.D633Y	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	633					nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GCTCTGTGAAGATCTCATCTG	0.438000													14	46					0.000219431	0.000232091	1	1	0
WDR43	23160	broad.mit.edu	37	2	29158461	29158461	+	Silent	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr2:29158461G>A	ENST00000407426.3	+	12	1568	c.1512G>A	c.(1510-1512)ccG>ccA	p.P504P		NM_015131.1	NP_055946.1	Q15061	WDR43_HUMAN	WD repeat domain 43	504						nucleolus				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	20	Acute lymphoblastic leukemia(172;0.155)					CTATTATTCCGTTGTTACAAG	0.323000													12	31					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53889416	53889416	+	Missense_Mutation	SNP	C	C	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr15:53889416C>A	ENST00000396328.1	-	18	3247	c.3008G>T	c.(3007-3009)aGt>aTt	p.S1003I	WDR72_ENST00000557913.1_Missense_Mutation_p.S1000I|WDR72_ENST00000360509.5_Missense_Mutation_p.S1003I|WDR72_ENST00000559418.1_Missense_Mutation_p.S1013I	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	1003										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		CTTTCCCAAACTCTTCATGTG	0.388000													15	67					5.01169e-05	5.45828e-05	1	1	0
RP11-24M17.5	0	broad.mit.edu	37	15	76074504	76074504	+	RNA	SNP	C	C	T	rs146281026	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr15:76074504C>T	ENST00000395215.3	+	0	683																											TGAACGCACACGTGACACAGG	0.572000													3	30					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319329	21319329	+	Silent	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:21319329G>A	ENST00000583088.1	+	3	1570	c.675G>A	c.(673-675)gaG>gaA	p.E225E	KCNJ12_ENST00000331718.5_Silent_p.E225E	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		ACATTGTGGAGGCCCATGTGC	0.642000										Prostate(3;0.18)			4	84					0	0	1	0	0
OR10J5	127385	broad.mit.edu	37	1	159505384	159505384	+	Silent	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:159505384C>T	ENST00000334857.2	-	1	458	c.414G>A	c.(412-414)aaG>aaA	p.K138K		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					CACATAGTCCCTTGCTCATGA	0.502000													4	85					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104155079	104155079	+	Splice_Site	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:104155079C>T	ENST00000388887.2	+	66	7454	c.7248_splice	c.e66-1	p.T2417_splice	RP11-341G23.4_ENST00000551299.1_RNA	NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	2417	FAS1 7.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity	p.T2417M(1)		NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TTTCCCTAGACGGAGACCAGG	0.512000													7	33					0	0	1	0	0
TMEM125	128218	broad.mit.edu	37	1	43738488	43738488	+	Missense_Mutation	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:43738488G>A	ENST00000432792.2	+	4	665	c.95G>A	c.(94-96)cGg>cAg	p.R32Q	TMEM125_ENST00000439858.1_Missense_Mutation_p.R32Q			Q96AQ2	TM125_HUMAN	transmembrane protein 125	32						integral to membrane				breast(1)|large_intestine(1)|lung(1)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CAGCAGCCGCGGCGCTCGGCG	0.711000													3	13					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161318010	161318010	+	Silent	SNP	C	C	G			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:161318010C>G	ENST00000428797.2	+	9	1165	c.810C>G	c.(808-810)gtC>gtG	p.V270V	GABRA1_ENST00000023897.6_Silent_p.V270V|GABRA1_ENST00000437025.2_Silent_p.V270V|GABRA1_ENST00000420560.1_Silent_p.V270V|GABRA1_ENST00000444819.1_Silent_p.V270V|GABRA1_ENST00000393943.4_Silent_p.V270V	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	270					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	TCTCACAAGTCTCCTTCTGGC	0.408000													61	10					0	0	1	0	0
SSTR4	6754	broad.mit.edu	37	20	23016994	23016994	+	Missense_Mutation	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr20:23016994G>A	ENST00000255008.3	+	1	938	c.874G>A	c.(874-876)Gtc>Atc	p.V292I	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	292					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TGATGCCACCGTCAACCACGT	0.567000													46	21					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46847428	46847428	+	Missense_Mutation	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:46847428G>A	ENST00000393382.3	-	14	2213	c.2072C>T	c.(2071-2073)tCc>tTc	p.S691F	TTLL6_ENST00000433608.2_Missense_Mutation_p.S384F	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	643						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						TTGGGTGGTGGATTCTGGGGT	0.498000													11	88					0	0	1	0	0
FOXR2	139628	broad.mit.edu	37	X	55650343	55650343	+	Missense_Mutation	SNP	C	C	A	rs142979047	byFrequency	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chrX:55650343C>A	ENST00000339140.3	+	1	511	c.199C>A	c.(199-201)Cct>Act	p.P67T		NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	67					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						GAGACCCAGTCCTGATGGAGA	0.552000													25	36					1.1804e-14	1.36677e-14	1	1	0
ZNF384	0	broad.mit.edu	37	12	6787485	6787485	+	Missense_Mutation	SNP	G	G	C			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:6787485G>C	ENST00000396795.1	-	5	991	c.494C>G	c.(493-495)tCc>tGc	p.S165C	ZNF384_ENST00000319770.3_Missense_Mutation_p.S149C|ZNF384_ENST00000396799.2_Missense_Mutation_p.S165C|ZNF384_ENST00000396801.3_Missense_Mutation_p.S165C|ZNF384_ENST00000361959.3_Missense_Mutation_p.S165C|ZNF384_ENST00000355772.4_Missense_Mutation_p.S110C			Q8TF68	ZN384_HUMAN	zinc finger protein 384	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						TACCTTCTTGGAGAGGTCAGG	0.607000			T	"""EWSR1, TAF15 """	ALL								24	20					0	0	1	0	0
AC226119.5	0	broad.mit.edu	37	4	3952901	3952901	+	RNA	SNP	A	A	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr4:3952901A>T	ENST00000281228.8	-	0	206				FAM86EP_ENST00000313946.8_RNA																							CACCGGGCATACTTGACTGAC	0.552000													4	53					0	0	1	0	0
MATR3	9782	broad.mit.edu	37	5	138643467	138643467	+	Missense_Mutation	SNP	C	C	G			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:138643467C>G	ENST00000394800.2	+	6	912	c.363C>G	c.(361-363)gaC>gaG	p.D121E	MATR3_ENST00000361059.2_Missense_Mutation_p.D121E|MATR3_ENST00000503811.1_Intron|MATR3_ENST00000510056.1_Missense_Mutation_p.D121E|MATR3_ENST00000509990.1_Missense_Mutation_p.D121E|MATR3_ENST00000394805.3_Missense_Mutation_p.D121E|MATR3_ENST00000502499.1_Intron|MATR3_ENST00000502929.1_Missense_Mutation_p.D121E|MATR3_ENST00000504203.1_Intron			P43243	MATR3_HUMAN	matrin 3	121						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CTGCTAGAGACTTAGATGAAC	0.463000													9	52					0	0	1	0	0
UGDH	7358	broad.mit.edu	37	4	39506922	39506922	+	Missense_Mutation	SNP	G	G	C			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr4:39506922G>C	ENST00000316423.6	-	9	1448	c.1106C>G	c.(1105-1107)cCa>cGa	p.P369R	UGDH_ENST00000507089.1_Missense_Mutation_p.P272R|UGDH_ENST00000506179.1_Missense_Mutation_p.P369R|UGDH_ENST00000501493.2_Missense_Mutation_p.P302R	NM_001184701.1|NM_003359.3	NP_001171630.1|NP_003350.1	O60701	UGDH_HUMAN	UDP-glucose 6-dehydrogenase	369					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			breast(1)|central_nervous_system(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(2)	27					NADH(DB00157)	AGGTACTTTTGGATCATATAT	0.348000													11	37					0	0	1	0	0
SYT15	83849	broad.mit.edu	37	10	46964009	46964009	+	Silent	SNP	G	G	C			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:46964009G>C	ENST00000374323.3	-	6	1700	c.1113C>G	c.(1111-1113)gtC>gtG	p.V371V	SYT15_ENST00000374325.3_Silent_p.V318V|RP11-38L15.3_ENST00000506914.1_RNA|SYT15_ENST00000374321.4_Silent_p.V318V|SYT15_ENST00000503753.1_Silent_p.V318V			Q9BQS2	SYT15_HUMAN	synaptotagmin XV	318	C2 2.					integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						GAGACACTTTGACAAACACAC	0.562000													19	152					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5282948	5282948	+	Missense_Mutation	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr20:5282948C>T	ENST00000546004.1	-	3	1139	c.893G>A	c.(892-894)cGt>cAt	p.R298H	PROKR2_ENST00000217270.3_Missense_Mutation_p.R298H			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	298						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						GAAGAAGTCACGAACGATGGT	0.562000										HNSCC(71;0.22)			42	22					0	0	1	0	0
AKR1E2	83592	broad.mit.edu	37	10	4877922	4877922	+	Missense_Mutation	SNP	A	A	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:4877922A>T	ENST00000298375.7	+	4	451	c.380A>T	c.(379-381)cAt>cTt	p.H127L	AKR1E2_ENST00000345253.5_Missense_Mutation_p.H127L|AKR1E2_ENST00000525281.1_3'UTR|AKR1E2_ENST00000532248.1_Missense_Mutation_p.H127L|AKR1E2_ENST00000334019.4_Missense_Mutation_p.H127L	NM_001040177.1	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	127						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						TGCCTCTCACATCCTCGAGTG	0.512000													4	55					0	0	1	0	0
USP42	84132	broad.mit.edu	37	7	6175578	6175578	+	Missense_Mutation	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr7:6175578G>A	ENST00000306177.5	+	4	707	c.549G>A	c.(547-549)atG>atA	p.M183I		NM_032172.2	NP_115548.1	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	183					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(2)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	35		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		TCAATGAGATGCGGCGTAAGT	0.348000													8	12					0	0	1	0	0
CCR7	1236	broad.mit.edu	37	17	38711153	38711153	+	Silent	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:38711153G>A	ENST00000246657.2	-	3	1040	c.978C>T	c.(976-978)taC>taT	p.Y326Y	CCR7_ENST00000579344.1_Silent_p.Y320Y	NM_001838.3	NP_001829.1	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7	326					cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		Breast(137;0.000496)				CGATGAAGGCGTACAAGAAAG	0.587000													14	45					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8331734	8331734	+	Silent	SNP	G	G	A	rs143526425	byFrequency	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr9:8331734G>A	ENST00000381196.4	-	41	5925	c.5382C>T	c.(5380-5382)gaC>gaT	p.D1794D	PTPRD_ENST00000355233.5_Silent_p.D1388D|PTPRD_ENST00000397606.3_Silent_p.D1387D|PTPRD_ENST00000537002.1_Silent_p.D1384D|PTPRD_ENST00000397611.3_Silent_p.D1384D|PTPRD_ENST00000358503.5_Silent_p.D1772D|PTPRD_ENST00000540109.1_Silent_p.D1794D|PTPRD_ENST00000360074.4_Silent_p.D1781D|PTPRD_ENST00000397617.3_Silent_p.D1387D|PTPRD_ENST00000486161.1_Silent_p.D1387D|PTPRD_ENST00000356435.5_Silent_p.D1794D	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1794	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGGACTGGCCGTCCTTTAGAA	0.512000										TSP Lung(15;0.13)			13	32					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62272447	62272447	+	Missense_Mutation	SNP	C	C	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:62272447C>A	ENST00000258991.3	-	3	1737	c.1653G>T	c.(1651-1653)atG>atT	p.M551I	TEX2_ENST00000583097.1_Missense_Mutation_p.M551I|TEX2_ENST00000584379.1_Missense_Mutation_p.M551I			Q8IWB9	TEX2_HUMAN	testis expressed 2	551					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		AAATCTCATTCATCCATCCCT	0.383000													6	56					5.9392e-07	6.66645e-07	1	1	0
MAG	4099	broad.mit.edu	37	19	35791110	35791110	+	Missense_Mutation	SNP	G	G	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr19:35791110G>T	ENST00000361922.4	+	6	923	c.773G>T	c.(772-774)aGc>aTc	p.S258I	MAG_ENST00000392213.3_Missense_Mutation_p.S258I|MAG_ENST00000537831.2_Missense_Mutation_p.S233I	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	258	Ig-like C2-type 2.				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TCCCACGTGAGCCTGCTCTGT	0.677000													7	9					0.00198382	0.00202056	1	1	0
AC024560.3	0	broad.mit.edu	37	3	197348646	197348646	+	RNA	SNP	T	T	C	rs138265355	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr3:197348646T>C	ENST00000418868.1	-	0	613					NR_003266.2																						TGGGCCTGCCTGCCCTTTCCA	0.532000													6	91					0	0	1	0	0
PPP2R2D	55844	broad.mit.edu	37	10	133758848	133758848	+	Silent	SNP	C	C	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:133758848C>A	ENST00000422256.2	+	4	509	c.24C>A	c.(22-24)atC>atA	p.I8I	PPP2R2D_ENST00000470416.1_3'UTR			Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B, delta	235	Poly-Gly.				cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			endometrium(3)|large_intestine(3)|liver(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		CCGAAGTCATCACTGCAGCCG	0.562000													15	97					2.31682e-05	2.5485e-05	1	1	0
FCGBP	8857	broad.mit.edu	37	19	40374023	40374023	+	Missense_Mutation	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr19:40374023C>T	ENST00000221347.6	-	26	12062	c.12055G>A	c.(12055-12057)Gtg>Atg	p.V4019M		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4019	Cys-rich.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGGCACACCACGACTTTACCC	0.642000													3	18					0	0	1	0	0
ZKSCAN7	55888	broad.mit.edu	37	3	44611529	44611529	+	Silent	SNP	A	A	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr3:44611529A>T	ENST00000273320.3	+	6	1356	c.927A>T	c.(925-927)gcA>gcT	p.A309A	ZKSCAN7_ENST00000341840.3_Intron|ZKSCAN7_ENST00000426540.1_Silent_p.A309A|RP11-944L7.4_ENST00000457331.1_RNA|ZKSCAN7_ENST00000431636.1_Intron	NM_018651.2	NP_061121.2			zinc finger with KRAB and SCAN domains 7																		CTGGGGCAGCAGAGACTGGAG	0.438000													28	116					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26886102	26886102	+	Missense_Mutation	SNP	G	G	C			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:26886102G>C	ENST00000231021.4	-	10	1775	c.1603C>G	c.(1603-1605)Ccg>Gcg	p.P535A		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	535	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.P535T(1)		breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						GTGAAATTCGGATTGAGAGTA	0.318000													4	94					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90895680	90895680	+	Silent	SNP	C	C	G			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr7:90895680C>G	ENST00000287934.2	+	1	1898	c.1485C>G	c.(1483-1485)ctC>ctG	p.L495L		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	495					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			TGGCGCCCCTCTTCGTGTACC	0.622000													74	100					0	0	1	0	0
TAS2R1	50834	broad.mit.edu	37	5	9630016	9630016	+	Silent	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:9630016C>T	ENST00000382492.2	-	1	447	c.129G>A	c.(127-129)ccG>ccA	p.P43P	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	43					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						GGAGATCCAGCGGAGCCATTT	0.378000													8	72					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52139791	52139791	+	Missense_Mutation	SNP	G	G	A			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:52139791G>A	ENST00000354534.5	+	13	2281	c.2103G>A	c.(2101-2103)atG>atA	p.M701I	SCN8A_ENST00000545061.1_Missense_Mutation_p.M701I|SCN8A_ENST00000550891.1_Missense_Mutation_p.M701I	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	701					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	ACAGTATAATGAGTGTTGTTA	0.403000													22	19					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50139907	50139907	+	Silent	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr20:50139907C>T	ENST00000371564.3	-	2	1092	c.873G>A	c.(871-873)ccG>ccA	p.P291P	NFATC2_ENST00000414705.1_Silent_p.P271P|NFATC2_ENST00000396009.3_Silent_p.P291P	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	291					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GGTACCCAGCCGGGGAGCCGT	0.697000													16	17					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71780304	71780304	+	Missense_Mutation	SNP	G	G	C	rs150417363		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr2:71780304G>C	ENST00000258104.3	+	20	2193	c.1916G>C	c.(1915-1917)cGt>cCt	p.R639P	DYSF_ENST00000394120.2_Missense_Mutation_p.R640P|DYSF_ENST00000409366.1_Missense_Mutation_p.R640P|DYSF_ENST00000429174.2_Missense_Mutation_p.R639P|DYSF_ENST00000409744.1_Missense_Mutation_p.R626P|DYSF_ENST00000413539.2_Missense_Mutation_p.R670P|DYSF_ENST00000410020.3_Missense_Mutation_p.R657P|DYSF_ENST00000409762.1_Missense_Mutation_p.R656P|DYSF_ENST00000410041.1_Missense_Mutation_p.R657P|DYSF_ENST00000409582.3_Missense_Mutation_p.R656P|DYSF_ENST00000409651.1_Missense_Mutation_p.R671P	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	639						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CAGTACAGCCGTGCAGTCTTT	0.582000													10	113					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74411041	74411041	+	Splice_Site	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr3:74411041C>T	ENST00000263665.6	-	10	1391	c.1364_splice	c.e10+1	p.R455_splice		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	455	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ATCAAAATACCTTTCATGCTC	0.448000													27	21					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	94					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129905829	129905829	+	Silent	SNP	T	T	C			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:129905829T>C	ENST00000368654.3	-	13	4650	c.4275A>G	c.(4273-4275)ggA>ggG	p.G1425G	MKI67_ENST00000368653.3_Silent_p.G1065G	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1425	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TATCCTCACCTCCTGGTACTT	0.483000													5	241					0	0	1	0	0
RAB42	115273	broad.mit.edu	37	1	28920318	28920318	+	Missense_Mutation	SNP	A	A	T			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:28920318A>T	ENST00000373826.3	+	2	313	c.7A>T	c.(7-9)Act>Tct	p.T3S	TAF12_ENST00000471683.1_Intron|RAB42_ENST00000465518.1_3'UTR	NM_152304.1	NP_689517.1	Q8N4Z0	RAB42_HUMAN	RAB42, member RAS oncogene family	3					small GTPase mediated signal transduction	membrane	GTP binding			breast(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00618)|all_lung(284;0.00909)|Breast(348;0.0249)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0577)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00298)|KIRC - Kidney renal clear cell carcinoma(1967;0.00948)|BRCA - Breast invasive adenocarcinoma(304;0.0213)|READ - Rectum adenocarcinoma(331;0.0649)		GGTCATGGCCACTCAGGGCCC	0.577000													7	6					0	0	1	0	0
RP11-782C8.2	0	broad.mit.edu	37	1	143146075	143146076	+	RNA	INS	-	-	T	rs151057799		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:143146075_143146076insT	ENST00000412204.2	-	0	2503				RP11-782C8.1_ENST00000438000.1_lincRNA																							aagactctgtctcaaaaaaaaa	0.411													3	4	---	---	---	---					
CD34	947	broad.mit.edu	37	1	208070903	208070903	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:208070903delA	ENST00000356522.4	-	4	853	c.532delT	c.(532-534)cafs	p.S178fs	CD34_ENST00000310833.7_Frame_Shift_Del_p.S178fs|CD34_ENST00000537704.1_Frame_Shift_Del_p.S43fs|CD34_ENST00000485761.1_5'UTR	NM_001773.2	NP_001764.1	P28906	CD34_HUMAN	CD34 molecule	178					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			kidney(2)|large_intestine(2)|lung(8)|ovary(1)	13						CTGATGCCTGAACATTTGATT	0.418													2	4	---	---	---	---					
AC016995.3	0	broad.mit.edu	37	2	38710017	38710019	+	RNA	DEL	AAT	AAT	-	rs2005502	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr2:38710017_38710019delAAT	ENST00000417039.1	-	0	696																											TTCTTtaaaaaataaataaataa	0.246													4	9	---	---	---	---					
LINC00884	0	broad.mit.edu	37	3	194230007	194230008	+	RNA	INS	-	-	T	rs71882311		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr3:194230007_194230008insT	ENST00000448892.1	+	0	1471				LINC00884_ENST00000437597.1_RNA	NR_033929.1																						TTCCTCTCttcttttttttttt	0.455													2	4	---	---	---	---					
SRP72	6731	broad.mit.edu	37	4	57333819	57333820	+	Frame_Shift_Ins	INS	-	-	G	rs17524437	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr4:57333819_57333820insG	ENST00000342756.5	+	1	739_740	c.18_19insG	c.(16-21)agggggfs	p.RG6fs	SRP72_ENST00000504757.1_Frame_Shift_Ins_p.RG6fs|SRP72_ENST00000510663.1_Frame_Shift_Ins_p.RG6fs	NM_006947.3	NP_008878.3	O76094	SRP72_HUMAN	signal recognition particle 72kDa	6					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(7)|ovary(2)	22	Glioma(25;0.08)|all_neural(26;0.101)					GCGGCGGCAGCGGGGGGGTGTC	0.639													10	21	---	---	---	---					
CTB-12O2.1	0	broad.mit.edu	37	5	151498883	151498883	+	RNA	DEL	G	G	-			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:151498883delG	ENST00000524295.1	+	0	199																											CAGTTGGAGTGGGATGAGACA	0.522													2	4	---	---	---	---					
STAG3L4	0	broad.mit.edu	37	7	66772495	66772495	+	RNA	DEL	T	T	-			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr7:66772495delT	ENST00000416602.2	+	0	362					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				GCTTGATTCCTTTTTTTTTTT	0.423													3	3	---	---	---	---					
ZNF252P-AS1	0	broad.mit.edu	37	8	146228843	146228843	+	RNA	DEL	G	G	-			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr8:146228843delG	ENST00000527067.1	+	0	647					NR_026974.1																						GGCGGCGGGCGGGGGTGAAGC	0.652													2	4	---	---	---	---					
RP11-262H14.1	0	broad.mit.edu	37	9	66460027	66460027	+	RNA	DEL	T	T	-	rs112286776		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr9:66460027delT	ENST00000424345.1	+	0	224																											ttgggaaggcttttcacatat	0.343													4	3	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68406889	68406889	+	RNA	DEL	G	G	-	rs141841413	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr9:68406889delG	ENST00000417843.2	-	0	224																											atccagggcagtcatagtggt	0.498													3	5	---	---	---	---					
RP11-229P13.20	0	broad.mit.edu	37	9	139931682	139931683	+	RNA	INS	-	-	GTGGGC	rs149732889	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr9:139931682_139931683insGTGGGC	ENST00000457302.2	+	0	191_192																											AGTGAAGGATGGTGGGCGTGGG	0.678													4	2	---	---	---	---					
RP11-405A12.2	0	broad.mit.edu	37	12	20103413	20103414	+	RNA	INS	-	-	TTC	rs35481088		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:20103413_20103414insTTC	ENST00000535764.1	+	0	378																											ggttaatttctttttttttttt	0.510													4	2	---	---	---	---					
IGHV4-61	0	broad.mit.edu	37	14	107095573	107095573	+	RNA	DEL	G	G	-			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr14:107095573delG	ENST00000390630.2	-	0	89																											TTCTTGCACAGGAGGTCCAGG	0.507													5	9	---	---	---	---					
HERC2P9	0	broad.mit.edu	37	15	28929261	28929261	+	RNA	DEL	T	T	-			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr15:28929261delT	ENST00000528584.1	+	0	1811					NR_036443.1																						TAAAGTCCAGTTTTTTTCCTG	0.303													2	4	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102294302	102294304	+	RNA	DEL	GCT	GCT	-			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr15:102294302_102294304delGCT	ENST00000561463.1	+	0	2348_2350																											TCTTCTCAGAGCTGCTGTCCAAC	0.591													2	4	---	---	---	---					
RP11-1166P10.6	0	broad.mit.edu	37	16	32031891	32031892	+	RNA	INS	-	-	G	rs138909480	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr16:32031891_32031892insG	ENST00000566806.1	-	0	499																											GAAAATGCCCAGGGGGGCCCAG	0.574													2	4	---	---	---	---					
CTB-171A8.1	0	broad.mit.edu	37	19	45193191	45193191	+	RNA	DEL	C	C	-			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr19:45193191delC	ENST00000590796.1	-	0	408																											cccttgcacacccccaggcac	0.572													2	4	---	---	---	---					
FAM182A	0	broad.mit.edu	37	20	26054752	26054754	+	RNA	DEL	ATC	ATC	-	rs112967123		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr20:26054752_26054754delATC	ENST00000376398.2	+	0	819					NR_026713.1															breast(1)|endometrium(2)|kidney(1)	4						caccatcattatcatcattacta	0.399													3	4	---	---	---	---					
GNAS-AS1	0	broad.mit.edu	37	20	57405511	57405513	+	RNA	DEL	CAC	CAC	-			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr20:57405511_57405513delCAC	ENST00000424094.2	-	0	819				GNAS-AS1_ENST00000598163.1_RNA	NR_002785.2																						ccaccaccatcaccaccaccaca	0.557													3	5	---	---	---	---					
RP5-1043L13.1	0	broad.mit.edu	37	20	58720112	58720114	+	RNA	DEL	CTC	CTC	-			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr20:58720112_58720114delCTC	ENST00000432910.1	+	0	153					NR_046099.1																						ATTTTTCCCACTCCTCCTTCCCC	0.379													4	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11048361	11048361	+	RNA	DEL	A	A	-	rs71293628		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr21:11048361delA	ENST00000470054.1	-	0	659									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGGGGAAGAGAAAAAAACAGG	0.408													3	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11062343	11062344	+	RNA	INS	-	-	AG	rs148978863		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr21:11062343_11062344insAG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAGTAAAAGACAGCAACTTTCA	0.267													4	6	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11066883	11066884	+	RNA	INS	-	-	AA	rs147216020		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr21:11066883_11066884insAA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTAGAATCCATAATACTCTCAG	0.366													3	3	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11069012	11069013	+	RNA	INS	-	-	C	rs150046862		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr21:11069012_11069013insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tttttcaacttcaaaaaattaa	0.272													4	6	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11088487	11088488	+	RNA	DEL	TG	TG	-	rs113519528	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr21:11088487_11088488delTG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tttgtttttttgttgttgttgt	0.401													2	4	---	---	---	---					
LINC00478	0	broad.mit.edu	37	21	17741884	17741884	+	RNA	DEL	A	A	-	rs77858910		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr21:17741884delA	ENST00000458468.1	+	0	469					NR_027790.1																						CCCCCTGGCCAAAAAAAAGCC	0.458													2	4	---	---	---	---					
GGT3P	0	broad.mit.edu	37	22	18771547	18771547	+	RNA	DEL	G	G	-	rs149629602		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr22:18771547delG	ENST00000412448.1	-	0	834																											TTTTTGttttgtttttttttt	0.433													3	6	---	---	---	---					
