Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FN1	2335	broad.mit.edu	37	2	216238117	216238117	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr2:216238117C>T	ENST00000354785.4	-	39	6544	c.6175G>A	c.(6175-6177)Gaa>Aaa	p.E2059K	FN1_ENST00000432072.2_Missense_Mutation_p.E1969K|FN1_ENST00000357009.2_Missense_Mutation_p.E1968K|FN1_ENST00000345488.5_Missense_Mutation_p.E1968K|FN1_ENST00000346544.3_Missense_Mutation_p.E1968K|FN1_ENST00000359671.1_Missense_Mutation_p.E1968K|FN1_ENST00000336916.4_Missense_Mutation_p.E1968K|FN1_ENST00000446046.1_Missense_Mutation_p.E1968K|FN1_ENST00000443816.1_Missense_Mutation_p.E1878K|FN1_ENST00000356005.4_Missense_Mutation_p.E1878K|FN1_ENST00000357867.4_Missense_Mutation_p.E1878K|FN1_ENST00000421182.1_Missense_Mutation_p.E1878K|FN1_ENST00000323926.6_Missense_Mutation_p.E2059K			P02751	FINC_HUMAN	fibronectin 1	1968	Connecting strand 3 (CS-3) (V region).				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding	p.E1968K(1)	FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATTGTATATTCGGTTCCCGGT	0.468000													4	84					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31439111	31439111	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:31439111C>T	ENST00000373747.3	-	13	1906	c.1807G>A	c.(1807-1809)Gca>Aca	p.A603T	PUM1_ENST00000373742.2_Missense_Mutation_p.A543T|PUM1_ENST00000257075.5_Missense_Mutation_p.A602T|PUM1_ENST00000490546.1_5'UTR|PUM1_ENST00000440538.2_Intron|PUM1_ENST00000426105.2_Missense_Mutation_p.A602T|PUM1_ENST00000424085.2_Missense_Mutation_p.A360T|PUM1_ENST00000423018.2_Missense_Mutation_p.A458T|PUM1_ENST00000373741.4_Missense_Mutation_p.A638T	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	602	Ala-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		GCTGAAGCTGCGGCTGCTGCA	0.473000													26	65					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	rs121912660		TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr17:7577099C>G	ENST00000420246.2	-	8	971	c.839G>C	c.(838-840)aGa>aCa	p.R280T	TP53_ENST00000455263.2_Missense_Mutation_p.R280T|TP53_ENST00000359597.4_Missense_Mutation_p.R280T|TP53_ENST00000269305.4_Missense_Mutation_p.R280T|TP53_ENST00000445888.2_Missense_Mutation_p.R280T|TP53_ENST00000413465.2_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	280	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(65)|p.R280K(49)|p.R280I(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.G279_R280delGR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	5					0	0	1	0	0
DENND1A	57706	broad.mit.edu	37	9	126143973	126143973	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr9:126143973G>A	ENST00000373624.2	-	22	2969	c.2768C>T	c.(2767-2769)aCg>aTg	p.T923M	DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000394219.3_Missense_Mutation_p.T934M|DENND1A_ENST00000542603.1_Missense_Mutation_p.T708M	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	923	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						CAGGGGCAACGTTCGGATCCT	0.687000													2	1					0	0	1	0	0
MT-ND4	4538	broad.mit.edu	37	MT	10854	10854	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrM:10854T>C	ENST00000361381.2	+	1	95	c.95T>C	c.(94-96)cTa>cCa	p.32_32insP						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						CACCCACAGCCTAATTATTAG	0.398000													35	12					0	0	1	0	0
WDR13	64743	broad.mit.edu	37	X	48458032	48458032	+	Silent	SNP	G	G	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrX:48458032G>A	ENST00000218056.5	+	4	955	c.450G>A	c.(448-450)ggG>ggA	p.G150G	WDR13_ENST00000492715.1_3'UTR	NM_001166426.1|NM_017883.4	NP_001159898.1|NP_060353.2	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13	150						cytoplasm|nucleus				endometrium(1)|large_intestine(4)|lung(4)|ovary(2)	11						CCATGGCCGGGGACACGTCAC	0.617000													23	52					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144757091	144757091	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr6:144757091G>T	ENST00000367545.3	+	9	876	c.876G>T	c.(874-876)gaG>gaT	p.E292D		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	292	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CTGAGGAGGAGCATGAGAGTC	0.498000													10	29					0.00621372	0.00621372	1	1	0
IFNA16	3449	broad.mit.edu	37	9	21217162	21217162	+	Missense_Mutation	SNP	G	G	C			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr9:21217162G>C	ENST00000380216.1	-	1	148	c.143C>G	c.(142-144)tCt>tGt	p.S48C		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	48					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		GGAGAAATGAGAGATTCTTCC	0.502000													67	41					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12121828	12121828	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr6:12121828C>A	ENST00000379388.2	+	4	2132	c.1800C>A	c.(1798-1800)aaC>aaA	p.N600K		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	600					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGGTGACAAACGTACAGCCAC	0.498000													51	49					6.32628e-17	7.54714e-17	1	1	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													4	40					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882546	228882546	+	Silent	SNP	G	G	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr2:228882546G>A	ENST00000392056.3	-	7	3070	c.3024C>T	c.(3022-3024)gaC>gaT	p.D1008D	SPHKAP_ENST00000344657.5_Silent_p.D1008D	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1008						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAGGGTGCTCGTCCGTCTTCC	0.517000													45	48					0	0	1	0	0
HCP5	0	broad.mit.edu	37	6	31431643	31431643	+	RNA	SNP	C	C	G			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr6:31431643C>G	ENST00000414046.2	+	0	715					NR_040662.1		Q6MZN7	HCP5_HUMAN							defense response					urinary_tract(1)	1						gggttccacacgaactcctcc	0.572000													19	150					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7550963	7550963	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr12:7550963G>T	ENST00000313599.3	-	7	1683	c.1626C>A	c.(1624-1626)gaC>gaA	p.D542E	CD163L1_ENST00000416109.2_Missense_Mutation_p.D552E|CD163L1_ENST00000396630.1_Missense_Mutation_p.D542E			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	542	SRCR 5.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TGCAAGAAACGTCATCCAGCC	0.413000													48	66					4.18559e-23	5.17491e-23	1	1	0
KIR3DL2	3812	broad.mit.edu	37	19	55363703	55363703	+	Silent	SNP	G	G	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:55363703G>A	ENST00000326321.3	+	3	354	c.321G>A	c.(319-321)tcG>tcA	p.S107S	KIR3DL2_ENST00000270442.5_Silent_p.S107S|KIR3DL1_ENST00000402254.2_Intron	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	107					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		CTGGGTGGTCGGCACCCAGCA	0.597000													81	3					0	0	1	0	0
HDAC5	10014	broad.mit.edu	37	17	42171102	42171102	+	Silent	SNP	G	G	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr17:42171102G>A	ENST00000225983.6	-	4	521	c.198C>T	c.(196-198)ggC>ggT	p.G66G	HDAC5_ENST00000336057.5_Silent_p.G65G|HDAC5_ENST00000393622.2_Silent_p.G65G|HDAC5_ENST00000586802.1_Silent_p.G65G			Q9UQL6	HDAC5_HUMAN	histone deacetylase 5	65					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		GGTCCACAGAGCCCACCAGAG	0.667000													7	1					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1802614	1802614	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:1802614C>A	ENST00000539485.1	-	11	1168	c.935G>T	c.(934-936)cGg>cTg	p.R312L	ATP8B3_ENST00000526092.1_Missense_Mutation_p.R259L|ATP8B3_ENST00000310127.6_Missense_Mutation_p.R312L|ATP8B3_ENST00000525591.1_Missense_Mutation_p.R259L			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	312					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGTGCATCCGACTGTTAGG	0.612000													5	5					0.000602214	0.000611203	1	1	0
SCRIB	23513	broad.mit.edu	37	8	144885555	144885555	+	Nonsense_Mutation	SNP	C	C	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr8:144885555C>A	ENST00000356994.2	-	24	3607	c.3601G>T	c.(3601-3603)Gag>Tag	p.E1201*	SCRIB_ENST00000377533.3_Nonsense_Mutation_p.E1120*|SCRIB_ENST00000320476.3_Nonsense_Mutation_p.E1201*	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	1201	Interaction with ARHGEF7.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TCGCTAACCTCCAGGGCTGCG	0.711000													5	29					0.000602214	0.000611203	1	1	0
SDC3	9672	broad.mit.edu	37	1	31347424	31347424	+	Silent	SNP	T	T	C			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:31347424T>C	ENST00000336798.7	-	2	2200	c.708A>G	c.(706-708)ccA>ccG	p.P236P	SDC3_ENST00000339394.6_Silent_p.P294P			O75056	SDC3_HUMAN	syndecan 3	294	Ser/Thr-rich (mucin-like).					integral to membrane	cytoskeletal protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		GGAAGGTCTCTGGAGTTGGGG	0.597000													69	64					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541792	40541792	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:40541792C>T	ENST00000434248.1	-	5	1039	c.974G>A	c.(973-975)cGa>cAa	p.R325Q	ZNF780B_ENST00000221355.6_Missense_Mutation_p.R177Q	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AGTATGAATTCGGCAATGTTC	0.388000													27	80					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29747234	29747234	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr10:29747234T>C	ENST00000375398.2	-	40	7036	c.6587A>G	c.(6586-6588)tAc>tGc	p.Y2196C	PTCHD3P1_ENST00000455774.1_RNA|PTCHD3P1_ENST00000414457.1_RNA|PTCHD3P1_ENST00000446807.1_RNA|PTCHD3P1_ENST00000445521.1_RNA|PTCHD3P1_ENST00000423223.1_RNA|PTCHD3P1_ENST00000438202.1_RNA|PTCHD3P1_ENST00000413405.1_RNA|SVIL_ENST00000535393.1_Missense_Mutation_p.Y1110C|SVIL_ENST00000375400.3_Missense_Mutation_p.Y1770C|SVIL_ENST00000355867.4_Missense_Mutation_p.Y2196C|PTCHD3P1_ENST00000430295.1_RNA			O95425	SVIL_HUMAN	supervillin	2196	HP.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CAGGGCGTTGTATTCATCCCT	0.572000													20	65					0	0	1	0	0
LPAR4	2846	broad.mit.edu	37	X	78010756	78010756	+	Silent	SNP	C	C	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrX:78010756C>A	ENST00000435339.2	+	2	795	c.390C>A	c.(388-390)acC>acA	p.T130T	LPAR4_ENST00000373301.2_Silent_p.T130T	NM_005296.2	NP_005287.1	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	130						integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			breast(3)|endometrium(3)|kidney(4)|large_intestine(4)|lung(16)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	38						TCTTTCTCACCTGTATTAGTG	0.468000													60	50					9.59835e-30	1.20868e-29	1	1	0
MAPK8IP3	23162	broad.mit.edu	37	16	1814128	1814128	+	Missense_Mutation	SNP	G	G	C			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr16:1814128G>C	ENST00000250894.4	+	18	2192	c.2035G>C	c.(2035-2037)Ggg>Cgg	p.G679R	MAPK8IP3_ENST00000356010.5_Missense_Mutation_p.G673R	NM_015133.3	NP_055948.2	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting protein 3	679					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding	p.G679W(1)		NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	42						GAGTCCCAACGGGGGCCAGGA	0.662000													15	19					0	0	1	0	0
GATSL3	652968	broad.mit.edu	37	22	30682353	30682353	+	Silent	SNP	C	C	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr22:30682353C>T	ENST00000407689.3	-	6	771	c.642G>A	c.(640-642)gaG>gaA	p.E214E	GATSL3_ENST00000404953.3_Intron|RP1-130H16.18_ENST00000447976.1_3'UTR|GATSL3_ENST00000459785.1_Intron	NM_001037666.2	NP_001032755.1			GATS protein-like 3											breast(1)|endometrium(1)|lung(1)	3						TAGAGGCTGCCTCCTTGGGGG	0.572000													34	2					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821878	5821878	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrX:5821878C>T	ENST00000381095.3	-	5	1468	c.841G>A	c.(841-843)Ggc>Agc	p.G281S	NLGN4X_ENST00000538097.1_Missense_Mutation_p.G281S|NLGN4X_ENST00000381092.1_Missense_Mutation_p.G281S|NLGN4X_ENST00000275857.6_Missense_Mutation_p.G281S|NLGN4X_ENST00000381093.2_Missense_Mutation_p.G301S	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	281					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						AGGGCGGTGCCGCTCTGAATG	0.532000													12	73					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135745373	135745373	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr2:135745373G>A	ENST00000375845.3	-	7	1099	c.1069C>T	c.(1069-1071)Cga>Tga	p.R357*	MAP3K19_ENST00000392915.1_Nonsense_Mutation_p.R374*|MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000358371.4_Nonsense_Mutation_p.R244*|MAP3K19_ENST00000315513.3_5'UTR	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		TCAGGTTTTCGCGTTTTACTA	0.378000													19	16					0	0	1	0	0
MYL10	93408	broad.mit.edu	37	7	101265461	101265461	+	Missense_Mutation	SNP	G	G	T	rs140607004		TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:101265461G>T	ENST00000223167.4	-	5	546	c.369C>A	c.(367-369)aaC>aaA	p.N123K		NM_138403.4	NP_612412.2	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	123						mitochondrion	calcium ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	12						CCAGTTCCTCGTTCTTGACAT	0.597000													33	41					4.74835e-14	5.38147e-14	1	1	0
GGT1	2678	broad.mit.edu	37	22	25011062	25011062	+	Missense_Mutation	SNP	C	C	G	rs138472970	by1000genomes	TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr22:25011062C>G	ENST00000400382.1	+	7	1105	c.350C>G	c.(349-351)aCc>aGc	p.T117S	GGT1_ENST00000248923.4_Missense_Mutation_p.T117S|GGT1_ENST00000400380.1_Missense_Mutation_p.T117S|GGT1_ENST00000406383.2_Missense_Mutation_p.T117S|GGT1_ENST00000400383.1_Missense_Mutation_p.T117S			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	117					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding	p.T117S(8)		breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	GCCTTTGCCACCATGTTCAAC	0.637000													5	30					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52569974	52569974	+	Silent	SNP	A	A	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:52569974A>T	ENST00000389534.4	-	7	1620	c.1161T>A	c.(1159-1161)tcT>tcA	p.S387S	ZNF841_ENST00000594295.1_Silent_p.S387S|ZNF432_ENST00000598446.1_Intron|ZNF841_ENST00000359973.2_Silent_p.S271S|ZNF841_ENST00000426391.2_Silent_p.S271S	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						GAGTTGCAAGAGAGGAACTTT	0.398000													16	7					0	0	1	0	0
PKM	5315	broad.mit.edu	37	15	72492887	72492887	+	Silent	SNP	G	G	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr15:72492887G>A	ENST00000319622.6	-	10	1873	c.1417C>T	c.(1417-1419)Ctg>Ttg	p.L473L	PKM_ENST00000389093.3_Silent_p.L473L|PKM_ENST00000335181.5_Silent_p.L473L|PKM_ENST00000568883.1_Silent_p.L308L|PKM_ENST00000565184.1_Silent_p.L473L|PKM_ENST00000568459.1_Silent_p.L473L|PKM_ENST00000449901.2_Silent_p.L458L|PKM_ENST00000565154.1_Silent_p.L473L	NM_001206796.1|NM_182470.2|NM_182471.2	NP_001193725.1|NP_872270.1|NP_872271.1			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						TCCTTGCACAGCACAGGGAAG	0.632000													56	59					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14341273	14341273	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr16:14341273C>T	ENST00000571589.1	+	12	2328	c.2156C>T	c.(2155-2157)aCc>aTc	p.T719I	MKL2_ENST00000341243.5_Missense_Mutation_p.T708I|MKL2_ENST00000574045.1_Intron|MKL2_ENST00000318282.5_Intron	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	708	Gln-rich.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCTTTACTGACCACGCAGACT	0.592000													19	11					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148389871	148389871	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr5:148389871C>A	ENST00000538184.1	-	10	2818	c.1930G>T	c.(1930-1932)Ggg>Tgg	p.G644W	SH3TC2_ENST00000515425.1_Missense_Mutation_p.G1097W|SH3TC2_ENST00000512049.1_Missense_Mutation_p.G1090W			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1097							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCGGGTCCCATTGAAGAAC	0.552000													17	0					2.35188e-11	2.62177e-11	1	1	0
AHR	196	broad.mit.edu	37	7	17362140	17362140	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:17362140C>T	ENST00000242057.4	+	3	912	c.269C>T	c.(268-270)tCc>tTc	p.S90F		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	90					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					TTAAAATCCTCCCCTACTGAA	0.343000													6	14					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86225393	86225393	+	Silent	SNP	A	A	G			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr15:86225393A>G	ENST00000394518.2	+	15	5201	c.5106A>G	c.(5104-5106)tcA>tcG	p.S1702S	AKAP13_ENST00000361243.2_Silent_p.S1706S|AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000394510.2_5'UTR	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1702					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						TTCTAGATTCACGGCCCTTCC	0.338000													11	48					0	0	1	0	0
PNMA3	29944	broad.mit.edu	37	X	152226402	152226402	+	Silent	SNP	G	G	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrX:152226402G>T	ENST00000447306.1	+	2	1326	c.990G>T	c.(988-990)ctG>ctT	p.L330L	PNMA3_ENST00000370264.4_Silent_p.L330L|PNMA3_ENST00000370265.4_Silent_p.L330L	NM_013364.4	NP_037496.3	Q9UL41	PNMA3_HUMAN	paraneoplastic Ma antigen 3	330					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	16	Acute lymphoblastic leukemia(192;6.56e-05)					tgaagctcctgcgtgaggagg	0.572000													14	55					1.5842e-08	1.70993e-08	1	1	0
ATP8B3	148229	broad.mit.edu	37	19	1802613	1802613	+	Silent	SNP	C	C	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:1802613C>A	ENST00000539485.1	-	11	1169	c.936G>T	c.(934-936)cgG>cgT	p.R312R	ATP8B3_ENST00000526092.1_Silent_p.R259R|ATP8B3_ENST00000310127.6_Silent_p.R312R|ATP8B3_ENST00000525591.1_Silent_p.R259R			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	312					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTGGTGCATCCGACTGTTAG	0.607000													5	5					0.000602214	0.000611203	1	1	0
MKI67	4288	broad.mit.edu	37	10	129901213	129901213	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr10:129901213C>T	ENST00000368654.3	-	13	9266	c.8891G>A	c.(8890-8892)cGg>cAg	p.R2964Q	MKI67_ENST00000368653.3_Missense_Mutation_p.R2604Q	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2964					cell proliferation	nucleolus	ATP binding|protein C-terminus binding	p.R2964P(1)		NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTTAGGGGCCCGAAGAACTCT	0.493000													4	110					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248308944	248308944	+	Silent	SNP	C	C	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:248308944C>A	ENST00000366476.1	+	1	495	c.495C>A	c.(493-495)tcC>tcA	p.S165S		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CGACATTTTCCTTCTCCTACT	0.448000													134	141					9.186e-65	1.17858e-64	1	1	0
TRBV6-8	0	broad.mit.edu	37	7	142124388	142124388	+	RNA	SNP	G	G	C			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:142124388G>C	ENST00000390376.2	-	0	89																											TCTTCAGGATGTGGAATTTTG	0.522000													4	103					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12735885	12735885	+	Silent	SNP	G	G	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrX:12735885G>A	ENST00000380682.1	+	16	3446	c.2940G>A	c.(2938-2940)ccG>ccA	p.P980P		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	980					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CCGACCTCCCGCCCAAAGTTG	0.572000													106	50					0	0	1	0	0
SPIRE2	84501	broad.mit.edu	37	16	89922030	89922030	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr16:89922030G>A	ENST00000378247.3	+	6	957	c.914G>A	c.(913-915)cGg>cAg	p.R305Q	SPIRE2_ENST00000393062.2_Missense_Mutation_p.R305Q	NM_032451.1	NP_115827.1	Q8WWL2	SPIR2_HUMAN	spire-type actin nucleation factor 2	305					transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		ATCCCGCCCCGGGTGAAGAAG	0.672000													27	15					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139412690	139412690	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr9:139412690G>A	ENST00000277541.6	-	7	1229	c.1154C>T	c.(1153-1155)tCc>tTc	p.S385F		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	385	EGF-like 10.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTCGCAGTTGGAGCCCTCGTT	0.672000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			5	18					0	0	1	0	0
SOX3	6658	broad.mit.edu	37	X	139586343	139586343	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrX:139586343C>T	ENST00000370536.2	-	1	882	c.883G>A	c.(883-885)Gcg>Acg	p.A295T		NM_005634.2	NP_005625.2	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	295					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	10	Acute lymphoblastic leukemia(192;7.65e-05)					ggcggcagcgcgggcggcggc	0.726000													5	5					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27803070	27803070	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr12:27803070C>T	ENST00000318304.8	+	7	882	c.599C>T	c.(598-600)aCa>aTa	p.T200I	PPFIBP1_ENST00000228425.6_Missense_Mutation_p.T200I|PPFIBP1_ENST00000542629.1_Missense_Mutation_p.T200I|PPFIBP1_ENST00000537927.1_Missense_Mutation_p.T47I	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	200					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					TTCAGAGACACAGAGGTGAGT	0.428000													10	28					0	0	1	0	0
LRRC6	23639	broad.mit.edu	37	8	133637655	133637655	+	Missense_Mutation	SNP	C	C	G			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr8:133637655C>G	ENST00000519595.1	-	6	797	c.699G>C	c.(697-699)gaG>gaC	p.E233D	LRRC6_ENST00000518642.1_Missense_Mutation_p.E233D|LRRC6_ENST00000520446.1_5'UTR|LRRC6_ENST00000250173.1_Missense_Mutation_p.E233D			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	233						cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TGTTGTGTTCCTCTGTGTCTG	0.388000													4	20					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42509903	42509903	+	Silent	SNP	G	G	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:42509903G>T	ENST00000262895.3	-	16	2234	c.2235C>A	c.(2233-2235)acC>acA	p.T745T	GRIK5_ENST00000301218.4_Silent_p.T745T|GRIK5_ENST00000593562.1_Silent_p.T745T	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	745						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CGTAGCCCTTGGTGTCGAGGA	0.627000													17	29					3.99206e-14	4.60102e-14	1	1	0
C7orf62	219557	broad.mit.edu	37	7	88423704	88423704	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:88423704G>T	ENST00000297203.2	-	2	738	c.553C>A	c.(553-555)Ctt>Att	p.L185I	ZNF804B_ENST00000333190.4_Intron	NM_152706.3	NP_689919.1	Q8TBZ9	CG062_HUMAN	chromosome 7 open reading frame 62	185										NS(1)|breast(1)|endometrium(3)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	30						GTCTGGCAAAGGTAGAGTGAC	0.428000													7	102					2.0095e-06	2.13509e-06	1	1	0
MGAM	8972	broad.mit.edu	37	7	141708409	141708409	+	Missense_Mutation	SNP	T	T	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:141708409T>A	ENST00000475668.2	+	3	285	c.231T>A	c.(229-231)gaT>gaA	p.D77E	MGAM_ENST00000549489.2_Missense_Mutation_p.D77E			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	77	Ser/Thr-rich.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTCCCCCAGATCCTGGAACAA	0.512000													25	31					0	0	1	0	0
OR12D2	26529	broad.mit.edu	37	6	29365088	29365088	+	Silent	SNP	T	T	C	rs144790258	by1000genomes	TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr6:29365088T>C	ENST00000383555.2	+	1	673	c.612T>C	c.(610-612)atT>atC	p.I204I	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						CGGGGACAATTGCCATGGGCC	0.443000													7	146					0	0	1	0	0
MST1L	0	broad.mit.edu	37	1	17083843	17083843	+	RNA	SNP	C	C	G			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:17083843C>G	ENST00000455405.2	-	0	745																											CCTTTCAGGACCCAGCAGTTG	0.577000													3	15					0	0	1	0	0
LRRC8E	80131	broad.mit.edu	37	19	7964528	7964528	+	Missense_Mutation	SNP	A	A	C			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:7964528A>C	ENST00000306708.6	+	3	1222	c.1121A>C	c.(1120-1122)gAc>gCc	p.D374A	AC010336.1_ENST00000539278.1_3'UTR	NM_001268284.1|NM_001268285.1|NM_025061.4	NP_001255213.1|NP_001255214.1|NP_079337.2	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member E	374						integral to membrane				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(10)	35						GATCAGTACGACTCCCTCTAC	0.567000													36	1					0	0	1	0	0
OR6K2	81448	broad.mit.edu	37	1	158670014	158670014	+	Silent	SNP	C	C	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:158670014C>A	ENST00000359610.2	-	1	472	c.429G>T	c.(427-429)ctG>ctT	p.L143L		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					AACTTAAAGTCAGTTGGGTAC	0.463000													29	75					2.65835e-16	3.11668e-16	1	1	0
ATP8B3	148229	broad.mit.edu	37	19	1802551	1802551	+	Missense_Mutation	SNP	T	T	A	rs142875994	by1000genomes	TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:1802551T>A	ENST00000539485.1	-	11	1231	c.998A>T	c.(997-999)aAc>aTc	p.N333I	ATP8B3_ENST00000526092.1_Missense_Mutation_p.N280I|ATP8B3_ENST00000310127.6_Missense_Mutation_p.N333I|ATP8B3_ENST00000525591.1_Missense_Mutation_p.N280I			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	333					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGGAGGAGGTTGCCAATGTC	0.572000													11	21					0	0	1	0	0
OR5T1	390155	broad.mit.edu	37	11	56043798	56043798	+	Silent	SNP	C	C	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr11:56043798C>A	ENST00000313033.2	+	1	770	c.684C>A	c.(682-684)atC>atA	p.I228I		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					TTGTCCTGATCTCCTATGGTT	0.433000													37	152					1.21669e-08	1.33444e-08	1	1	0
YARS	8565	broad.mit.edu	37	1	33245093	33245093	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:33245093C>A	ENST00000373477.4	-	12	2274	c.1366G>T	c.(1366-1368)Gac>Tac	p.D456Y	YARS_ENST00000469100.1_5'UTR	NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	456	tRNA-binding.				apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	GCCGGAGGGTCCAGAGGTTCA	0.542000													49	39					2.64894e-19	3.21657e-19	1	1	0
TAS2R41	259287	broad.mit.edu	37	7	143175364	143175364	+	Silent	SNP	C	C	G			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:143175364C>G	ENST00000408916.1	+	1	399	c.399C>G	c.(397-399)ctC>ctG	p.L133L	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	133					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					TGCCCTGGCTCCTGTTGGGCT	0.478000													14	56					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208315676	208315677	+	Frame_Shift_Ins	INS	-	-	TC			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:208315676_208315677insTC	ENST00000367033.3	-	4	2260_2261	c.1503_1504insGA	c.(1501-1506)agaggtfs	p.G502fs		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	502	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GCACTTACCTGTCTCTCAGACA	0.490													17	72	---	---	---	---					
AC010880.1	0	broad.mit.edu	37	2	16591406	16591408	+	RNA	DEL	CAT	CAT	-			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr2:16591406_16591408delCAT	ENST00000427950.1	+	0	157																											ccatcatgaccatcatcatcatc	0.404													2	4	---	---	---	---					
AC016995.3	0	broad.mit.edu	37	2	38710012	38710013	+	RNA	INS	-	-	A	rs71402229		TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr2:38710012_38710013insA	ENST00000417039.1	-	0	696																											CTTACTTCTTtaaaaaataaat	0.252													5	11	---	---	---	---					
AC013463.2	0	broad.mit.edu	37	2	165905596	165905596	+	RNA	DEL	T	T	-			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr2:165905596delT	ENST00000431341.1	+	0	299																											TTATTTTTACTTTTTGGTCCG	0.294													2	4	---	---	---	---					
CTC-340A15.2	0	broad.mit.edu	37	5	164196998	164196999	+	RNA	INS	-	-	C			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr5:164196998_164196999insC	ENST00000519570.1	+	0	346				CTC-340A15.2_ENST00000522646.1_RNA|CTC-340A15.2_ENST00000522303.1_RNA																							gggaagcaaggaccttctttac	0.470													2	4	---	---	---	---					
PMS2CL	0	broad.mit.edu	37	7	6781178	6781178	+	RNA	DEL	A	A	-			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:6781178delA	ENST00000486256.1	+	0	1694					NR_002217.1																						actctgtttcaaaaaaaaaga	0.403													3	5	---	---	---	---					
HIP1	3092	broad.mit.edu	37	7	75187513	75187515	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:75187513_75187515delCTT	ENST00000336926.6	-	15	1446_1448	c.1420_1422delAAG	c.(1420-1422)del	p.K474del	HIP1_ENST00000434438.2_In_Frame_Del_p.K474del	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	474	pDED.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GCTCGCTGTACTTCTCCTTTAGC	0.552			T	PDGFRB	CMML								35	42	---	---	---	---					
CTD-2281E23.3	0	broad.mit.edu	37	8	1197070	1197070	+	RNA	DEL	T	T	-	rs66617915		TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr8:1197070delT	ENST00000517950.1	-	0	311																											GATCAGTGTGTGGAGTGATGG	0.572													2	4	---	---	---	---					
INPP5E	56623	broad.mit.edu	37	9	139327477	139327487	+	Frame_Shift_Del	DEL	TGGTCTTGATC	TGGTCTTGATC	-			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr9:139327477_139327487delTGGTCTTGATC	ENST00000371712.3	-	5	1602_1612	c.1200_1210delGATCAAGACCA	c.(1198-1212)caagfs	p.QIKTK400fs		NM_019892.4	NP_063945.2	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase, 72 kDa	400						cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	p.Q400H(1)		NS(1)|endometrium(1)|lung(4)|skin(3)	9		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		AAGGCCCCCTTGGTCTTGATCTGAGACACGA	0.611													11	30	---	---	---	---					
INPP5E	56623	broad.mit.edu	37	9	139333399	139333399	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr9:139333399delC	ENST00000371712.3	-	1	875	c.473delG	c.(472-474)gtfs	p.G158fs		NM_019892.4	NP_063945.2	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase, 72 kDa	158	13 X 4 AA repeats of P-X-X-P.					cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			NS(1)|endometrium(1)|lung(4)|skin(3)	9		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		GAGAGGGTTACCCCCCGAGGA	0.721													2	4	---	---	---	---					
MYO7A	4647	broad.mit.edu	37	11	76883793	76883793	+	Splice_Site	DEL	G	G	-			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr11:76883793delG	ENST00000409709.3	+	16	2069		c.e16-1		MYO7A_ENST00000458637.2_Splice_Site|MYO7A_ENST00000409893.1_Splice_Site|MYO7A_ENST00000409619.2_Splice_Site	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA						actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CGTCCCCCCAGGGCGCCGAGA	0.687													2	4	---	---	---	---					
USP7	7874	broad.mit.edu	37	16	8999095	8999106	+	In_Frame_Del	DEL	GAACAGACAGGT	GAACAGACAGGT	-	rs146945749		TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr16:8999095_8999106delGAACAGACAGGT	ENST00000344836.4	-	14	1709_1720	c.1511_1522delACCTGTCTGTTC	c.(1510-1524)gga>g	p.DLSVR504del	USP7_ENST00000381886.4_In_Frame_Del_p.DLSVR488del|USP7_ENST00000535863.1_In_Frame_Del_p.DLSVR405del	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	504					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						GTGCAGTGTCGAACAGACAGGTCGTCATCGTG	0.434											OREG0023595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	32	---	---	---	---					
RP11-19N8.4	0	broad.mit.edu	37	16	33071230	33071232	+	RNA	DEL	AAT	AAT	-			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr16:33071230_33071232delAAT	ENST00000561541.1	-	0	291																											GATGGGAGAGAATAAGGAGGGCG	0.724													2	4	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)cafs	p.L454fs	CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs|CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs|CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													4	9	---	---	---	---					
