Clustering of miR mature expression: consensus hierarchical
Overview
Introduction
This pipeline calculates clusters based on consensus hierarchical clustering with agglomerative ward linkage[1],[2]. This pipeline has the following features:
-
Classify samples into consensus clusters.
-
Determine differentially expressed marker miRs for each subtype.
Summary
Median absolute deviation (MAD) was used to select 278 most variable miRs. Consensus ward linkage hierarchical clustering of 80 samples and 278 miRs identified 5 subtypes with the stability of the clustering increasing for k = 2 to k = 10.
Results
miR expression patterns of molecular subtypes
Figure 1. Get High-res Image Samples were separated into 5 clusters. Shown are 80 samples and 872 marker miRs. The color bar of the row indicates the marker miRs for the corresponding cluster.
Figure 2. Get High-res Image Heatmap with a standard hierarchical clustering for 80 samples and the 278 most variable miRs. *The NA values were changed to 0 for this figure.
Silhouette widths, Cophenetic Correlation Coefficients and Consensus matrix
Figure 3. Get High-res Image The silhouette width was calculated for each sample and each value of k. The left upper panel shows the average silhouette width across all samples for each tested k (left upper panel). The left lower panel shows the Cophenetic Correlation Coefficients for each tested k. The right panel shows assignments of clusters to samples and the k silhouette width of each sample for the most robust clustering.
Figure 4. Get High-res Image The consensus matrix after clustering shows 5 clusters with limited overlap between clusters.
Samples assignment with silhouette width
Table 1. Get Full Table List of samples with 5 subtypes and silhouette width.
| SampleName | cluster | silhouetteValue |
|---|---|---|
| TCGA-RZ-AB0B-01A-11R-A40B-13 | 1 | 0.23 |
| TCGA-V4-A9E7-01A-11R-A40B-13 | 1 | 0.26 |
| TCGA-V4-A9EE-01A-11R-A40B-13 | 1 | 0.091 |
| TCGA-V4-A9EQ-01A-11R-A40B-13 | 1 | 0.17 |
| TCGA-V4-A9ES-01A-11R-A40B-13 | 1 | 0.24 |
| TCGA-V4-A9EU-01A-11R-A40B-13 | 1 | -0.027 |
| TCGA-V4-A9EV-01A-11R-A40B-13 | 1 | 0.16 |
| TCGA-V4-A9F1-01A-11R-A40B-13 | 1 | 0.19 |
| TCGA-V4-A9F3-01A-11R-A40B-13 | 1 | 0.17 |
| TCGA-V4-A9F5-01A-11R-A40B-13 | 1 | 0.16 |
Table 2. Get Full Table List of samples belonging to each cluster in different k clusters.
| SampleName | K=2 | K=3 | K=4 | K=5 | K=6 | K=7 | K=8 | K=9 | K=10 |
|---|---|---|---|---|---|---|---|---|---|
| TCGA-RZ-AB0B-01A-11R-A40B-13 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| TCGA-V3-A9ZX-01A-11R-A40B-13 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| TCGA-V3-A9ZY-01A-11R-A40B-13 | 2 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| TCGA-V4-A9E5-01A-11R-A40B-13 | 2 | 3 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| TCGA-V4-A9E7-01A-11R-A40B-13 | 1 | 1 | 1 | 1 | 5 | 5 | 5 | 5 | 5 |
| TCGA-V4-A9E8-01A-11R-A40B-13 | 2 | 3 | 4 | 5 | 6 | 2 | 2 | 6 | 6 |
| TCGA-V4-A9E9-01A-11R-A40B-13 | 2 | 3 | 4 | 5 | 6 | 2 | 6 | 7 | 7 |
| TCGA-V4-A9EA-01A-11R-A40B-13 | 2 | 3 | 4 | 5 | 6 | 2 | 6 | 7 | 7 |
| TCGA-V4-A9EC-01A-11R-A40B-13 | 2 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| TCGA-V4-A9ED-01A-11R-A40B-13 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 6 | 6 |
Marker miRs of each subtype
Samples most representative of the clusters, hereby called core samples were identified based on positive silhouette width, indicating higher similarity to their own class than to any other class member. Core samples were used to select differentially expressed marker miRs for each subtype by comparing the subclass versus the other subclasses, using Student's t-test.
Table 3. Get Full Table List of marker miRs with p <= 0.05 (The positive value of column difference means miR is upregulated in this subtype and vice versa).
| Hybridization.REF | p | difference | q | subclass |
|---|---|---|---|---|
| HSA-MIR-142-3P|MIMAT0000434 | 0.000064 | 2.6 | 0.00065 | 1 |
| HSA-MIR-142-5P|MIMAT0000433 | 0.000045 | 2.5 | 0.0005 | 1 |
| HSA-MIR-592|MIMAT0003260 | 4.5e-06 | 2.1 | 0.000075 | 1 |
| HSA-MIR-10B-5P|MIMAT0000254 | 0.016 | 1.9 | 0.051 | 1 |
| HSA-MIR-708-5P|MIMAT0004926 | 0.000054 | 1.8 | 0.00057 | 1 |
| HSA-MIR-503-5P|MIMAT0002874 | 2.5e-07 | 1.8 | 7.1e-06 | 1 |
| HSA-MIR-155-5P|MIMAT0000646 | 0.000012 | 1.8 | 0.00016 | 1 |
| HSA-MIR-374A-5P|MIMAT0000727 | 0.000031 | 1.8 | 0.00036 | 1 |
| HSA-MIR-19A-3P|MIMAT0000073 | 0.000075 | 1.7 | 0.00073 | 1 |
| HSA-MIR-199A-5P|MIMAT0000231 | 0.00017 | 1.7 | 0.0013 | 1 |
| HSA-MIR-21-5P|MIMAT0000076 | 2.6e-07 | 1.7 | 7.1e-06 | 1 |
| HSA-MIR-155-3P|MIMAT0004658 | 0.00028 | 1.7 | 0.0019 | 1 |
| HSA-MIR-577|MIMAT0003242 | 0.00015 | 1.7 | 0.0013 | 1 |
| HSA-MIR-452-5P|MIMAT0001635 | 1.1e-06 | 1.6 | 0.000023 | 1 |
| HSA-MIR-653-5P|MIMAT0003328 | 0.00018 | 1.6 | 0.0014 | 1 |
| HSA-MIR-708-3P|MIMAT0004927 | 0.0033 | 1.5 | 0.016 | 1 |
| HSA-MIR-224-5P|MIMAT0000281 | 0.00016 | 1.5 | 0.0013 | 1 |
| HSA-MIR-144-5P|MIMAT0004600 | 0.0091 | 1.5 | 0.034 | 1 |
| HSA-MIR-21-3P|MIMAT0004494 | 0.00019 | 1.5 | 0.0014 | 1 |
| HSA-MIR-18A-5P|MIMAT0000072 | 3.6e-06 | 1.4 | 0.000064 | 1 |
| HSA-MIR-301A-3P|MIMAT0000688 | 0.00058 | 1.4 | 0.0035 | 1 |
| HSA-MIR-15A-5P|MIMAT0000068 | 1.5e-10 | 1.4 | 8.7e-09 | 1 |
| HSA-MIR-126-5P|MIMAT0000444 | 2.9e-07 | 1.4 | 7.6e-06 | 1 |
| HSA-MIR-132-3P|MIMAT0000426 | 4.8e-07 | 1.4 | 0.000011 | 1 |
| HSA-MIR-212-3P|MIMAT0000269 | 0.000057 | 1.4 | 0.00059 | 1 |
| HSA-MIR-887-3P|MIMAT0004951 | 0.0012 | 1.4 | 0.0065 | 1 |
| HSA-MIR-362-3P|MIMAT0004683 | 6.7e-07 | 1.3 | 0.000015 | 1 |
| HSA-MIR-340-5P|MIMAT0004692 | 1.7e-06 | 1.3 | 0.000033 | 1 |
| HSA-MIR-302B-3P|MIMAT0000715 | 0.026 | 1.3 | 0.078 | 1 |
| HSA-LET-7B-3P|MIMAT0004482 | 3e-10 | 1.3 | 1.7e-08 | 1 |
| HSA-MIR-188-5P|MIMAT0000457 | 5.3e-08 | 1.3 | 2.1e-06 | 1 |
| HSA-MIR-150-5P|MIMAT0000451 | 0.048 | 1.2 | 0.13 | 1 |
| HSA-MIR-199A-3P|MIMAT0000232 | 0.0086 | 1.2 | 0.033 | 1 |
| HSA-MIR-199B-3P|MIMAT0004563 | 0.0087 | 1.2 | 0.033 | 1 |
| HSA-MIR-29B-3P|MIMAT0000100 | 0.00039 | 1.2 | 0.0025 | 1 |
| HSA-MIR-937-3P|MIMAT0004980 | 0.0042 | 1.1 | 0.019 | 1 |
| HSA-MIR-193A-3P|MIMAT0000459 | 0.00016 | 1.1 | 0.0013 | 1 |
| HSA-MIR-424-5P|MIMAT0001341 | 0.00041 | 1.1 | 0.0026 | 1 |
| HSA-MIR-195-5P|MIMAT0000461 | 0.000057 | 1 | 0.00059 | 1 |
| HSA-MIR-497-5P|MIMAT0002820 | 5e-06 | 1 | 0.000077 | 1 |
| HSA-MIR-200B-3P|MIMAT0000318 | 0.00012 | 1 | 0.0011 | 1 |
| HSA-MIR-146B-5P|MIMAT0002809 | 0.024 | 1 | 0.07 | 1 |
| HSA-MIR-381-3P|MIMAT0000736 | 0.013 | 0.99 | 0.043 | 1 |
| HSA-MIR-2355-5P|MIMAT0016895 | 0.0047 | 0.99 | 0.021 | 1 |
| HSA-MIR-33A-3P|MIMAT0004506 | 0.00019 | 0.99 | 0.0014 | 1 |
| HSA-MIR-20A-5P|MIMAT0000075 | 0.0012 | 0.98 | 0.0065 | 1 |
| HSA-MIR-3940-3P|MIMAT0018356 | 0.0053 | 0.93 | 0.023 | 1 |
| HSA-LET-7A-3P|MIMAT0004481 | 0.00033 | 0.92 | 0.0022 | 1 |
| HSA-MIR-502-5P|MIMAT0002873 | 0.000019 | 0.87 | 0.00023 | 1 |
| HSA-MIR-3912-3P|MIMAT0018186 | 0.0012 | 0.87 | 0.0068 | 1 |
| HSA-MIR-27A-3P|MIMAT0000084 | 0.0003 | 0.86 | 0.002 | 1 |
| HSA-MIR-450B-5P|MIMAT0004909 | 0.0063 | 0.85 | 0.025 | 1 |
| HSA-MIR-101-3P|MIMAT0000099 | 0.04 | 0.82 | 0.11 | 1 |
| HSA-MIR-3191-3P|MIMAT0015075 | 0.0051 | 0.82 | 0.023 | 1 |
| HSA-MIR-200C-3P|MIMAT0000617 | 0.00021 | 0.81 | 0.0016 | 1 |
| HSA-MIR-346|MIMAT0000773 | 0.02 | 0.81 | 0.061 | 1 |
| HSA-MIR-542-5P|MIMAT0003340 | 0.003 | 0.8 | 0.014 | 1 |
| HSA-MIR-590-3P|MIMAT0004801 | 0.011 | 0.8 | 0.038 | 1 |
| HSA-MIR-145-3P|MIMAT0004601 | 0.01 | 0.79 | 0.037 | 1 |
| HSA-MIR-223-3P|MIMAT0000280 | 0.017 | 0.79 | 0.053 | 1 |
| HSA-MIR-19B-3P|MIMAT0000074 | 0.023 | 0.78 | 0.068 | 1 |
| HSA-MIR-542-3P|MIMAT0003389 | 0.0028 | 0.77 | 0.013 | 1 |
| HSA-MIR-3065-5P|MIMAT0015066 | 0.011 | 0.75 | 0.037 | 1 |
| HSA-MIR-16-1-3P|MIMAT0004489 | 0.006 | 0.74 | 0.025 | 1 |
| HSA-MIR-3065-3P|MIMAT0015378 | 0.0047 | 0.74 | 0.021 | 1 |
| HSA-MIR-504-5P|MIMAT0002875 | 0.045 | 0.74 | 0.12 | 1 |
| HSA-LET-7F-1-3P|MIMAT0004486 | 0.0015 | 0.73 | 0.0082 | 1 |
| HSA-MIR-106B-5P|MIMAT0000680 | 0.000074 | 0.73 | 0.00073 | 1 |
| HSA-MIR-24-2-5P|MIMAT0004497 | 0.00013 | 0.73 | 0.0011 | 1 |
| HSA-MIR-16-5P|MIMAT0000069 | 0.00027 | 0.72 | 0.0019 | 1 |
| HSA-MIR-330-5P|MIMAT0004693 | 0.014 | 0.69 | 0.046 | 1 |
| HSA-MIR-374B-5P|MIMAT0004955 | 0.013 | 0.69 | 0.044 | 1 |
| HSA-MIR-188-3P|MIMAT0004613 | 0.0092 | 0.69 | 0.034 | 1 |
| HSA-MIR-450A-5P|MIMAT0001545 | 0.0097 | 0.68 | 0.035 | 1 |
| HSA-MIR-132-5P|MIMAT0004594 | 0.0077 | 0.66 | 0.03 | 1 |
| HSA-MIR-24-3P|MIMAT0000080 | 0.000026 | 0.65 | 0.0003 | 1 |
| HSA-MIR-365A-3P|MIMAT0000710 | 0.0026 | 0.64 | 0.013 | 1 |
| HSA-MIR-195-3P|MIMAT0004615 | 0.0093 | 0.64 | 0.034 | 1 |
| HSA-MIR-590-5P|MIMAT0003258 | 0.05 | 0.63 | 0.13 | 1 |
| HSA-MIR-103A-2-5P|MIMAT0009196 | 0.0052 | 0.61 | 0.023 | 1 |
| HSA-MIR-215-5P|MIMAT0000272 | 0.009 | 0.61 | 0.034 | 1 |
| HSA-MIR-766-3P|MIMAT0003888 | 0.0097 | 0.6 | 0.035 | 1 |
| HSA-MIR-660-5P|MIMAT0003338 | 0.00036 | 0.6 | 0.0023 | 1 |
| HSA-MIR-148B-5P|MIMAT0004699 | 0.0023 | 0.6 | 0.012 | 1 |
| HSA-MIR-30B-5P|MIMAT0000420 | 0.014 | 0.59 | 0.046 | 1 |
| HSA-MIR-148B-3P|MIMAT0000759 | 0.00022 | 0.59 | 0.0016 | 1 |
| HSA-MIR-193B-3P|MIMAT0002819 | 0.023 | 0.59 | 0.068 | 1 |
| HSA-MIR-92B-3P|MIMAT0003218 | 0.0087 | 0.57 | 0.033 | 1 |
| HSA-MIR-532-5P|MIMAT0002888 | 0.0014 | 0.56 | 0.0077 | 1 |
| HSA-MIR-330-3P|MIMAT0000751 | 0.037 | 0.55 | 0.1 | 1 |
| HSA-MIR-27A-5P|MIMAT0004501 | 0.0057 | 0.54 | 0.024 | 1 |
| HSA-MIR-29B-1-5P|MIMAT0004514 | 0.02 | 0.53 | 0.061 | 1 |
| HSA-MIR-17-5P|MIMAT0000070 | 0.0062 | 0.53 | 0.025 | 1 |
| HSA-MIR-454-3P|MIMAT0003885 | 0.0063 | 0.52 | 0.025 | 1 |
| HSA-MIR-29A-5P|MIMAT0004503 | 0.013 | 0.51 | 0.043 | 1 |
| HSA-MIR-30D-5P|MIMAT0000245 | 0.0096 | 0.49 | 0.035 | 1 |
| HSA-MIR-342-3P|MIMAT0000753 | 0.011 | 0.48 | 0.038 | 1 |
| HSA-MIR-500B-5P|MIMAT0016925 | 0.0077 | 0.46 | 0.03 | 1 |
| HSA-MIR-500A-5P|MIMAT0004773 | 0.0078 | 0.46 | 0.03 | 1 |
| HSA-MIR-652-3P|MIMAT0003322 | 0.04 | 0.44 | 0.11 | 1 |
| HSA-MIR-22-3P|MIMAT0000077 | 0.032 | 0.39 | 0.092 | 1 |
| HSA-MIR-103A-3P|MIMAT0000101 | 0.0061 | 0.37 | 0.025 | 1 |
| HSA-MIR-671-5P|MIMAT0003880 | 0.04 | 0.37 | 0.11 | 1 |
| HSA-MIR-769-5P|MIMAT0003886 | 0.047 | -0.31 | 0.12 | 1 |
| HSA-LET-7D-5P|MIMAT0000065 | 0.029 | -0.32 | 0.084 | 1 |
| HSA-MIR-98-5P|MIMAT0000096 | 0.017 | -0.33 | 0.054 | 1 |
| HSA-MIR-339-3P|MIMAT0004702 | 0.0057 | -0.35 | 0.024 | 1 |
| HSA-MIR-505-3P|MIMAT0002876 | 0.048 | -0.38 | 0.13 | 1 |
| HSA-MIR-106B-3P|MIMAT0004672 | 0.021 | -0.39 | 0.064 | 1 |
| HSA-MIR-152-3P|MIMAT0000438 | 0.029 | -0.4 | 0.085 | 1 |
| HSA-MIR-92A-1-5P|MIMAT0004507 | 0.047 | -0.41 | 0.12 | 1 |
| HSA-MIR-93-3P|MIMAT0004509 | 0.013 | -0.43 | 0.044 | 1 |
| HSA-MIR-181C-3P|MIMAT0004559 | 0.036 | -0.44 | 0.1 | 1 |
| HSA-MIR-17-3P|MIMAT0000071 | 0.017 | -0.44 | 0.054 | 1 |
| HSA-MIR-7-1-3P|MIMAT0004553 | 0.025 | -0.46 | 0.073 | 1 |
| HSA-MIR-26B-5P|MIMAT0000083 | 0.021 | -0.49 | 0.064 | 1 |
| HSA-MIR-616-3P|MIMAT0004805 | 0.028 | -0.49 | 0.081 | 1 |
| HSA-MIR-2110|MIMAT0010133 | 0.05 | -0.49 | 0.13 | 1 |
| HSA-MIR-3917|MIMAT0018191 | 0.0099 | -0.5 | 0.035 | 1 |
| HSA-MIR-320A|MIMAT0000510 | 0.036 | -0.52 | 0.1 | 1 |
| HSA-MIR-181D-5P|MIMAT0002821 | 0.02 | -0.52 | 0.061 | 1 |
| HSA-MIR-1180-3P|MIMAT0005825 | 0.017 | -0.52 | 0.054 | 1 |
| HSA-MIR-1287-5P|MIMAT0005878 | 0.0066 | -0.53 | 0.026 | 1 |
| HSA-MIR-3684|MIMAT0018112 | 0.042 | -0.55 | 0.11 | 1 |
| HSA-MIR-627-5P|MIMAT0003296 | 0.027 | -0.56 | 0.079 | 1 |
| HSA-MIR-744-5P|MIMAT0004945 | 0.0054 | -0.56 | 0.023 | 1 |
| HSA-LET-7I-5P|MIMAT0000415 | 0.00015 | -0.57 | 0.0013 | 1 |
| HSA-MIR-320B|MIMAT0005792 | 0.033 | -0.58 | 0.092 | 1 |
| HSA-MIR-331-5P|MIMAT0004700 | 0.0083 | -0.59 | 0.032 | 1 |
| HSA-MIR-3605-3P|MIMAT0017982 | 0.011 | -0.59 | 0.037 | 1 |
| HSA-LET-7D-3P|MIMAT0004484 | 0.00061 | -0.6 | 0.0037 | 1 |
| HSA-MIR-140-5P|MIMAT0000431 | 0.012 | -0.61 | 0.04 | 1 |
| HSA-MIR-576-5P|MIMAT0003241 | 0.0092 | -0.62 | 0.034 | 1 |
| HSA-MIR-95-3P|MIMAT0000094 | 0.0055 | -0.62 | 0.023 | 1 |
| HSA-MIR-26A-5P|MIMAT0000082 | 0.00066 | -0.62 | 0.0039 | 1 |
| HSA-MIR-138-5P|MIMAT0000430 | 0.038 | -0.63 | 0.11 | 1 |
| HSA-LET-7G-5P|MIMAT0000414 | 4.9e-06 | -0.63 | 0.000077 | 1 |
| HSA-MIR-3928-3P|MIMAT0018205 | 0.00089 | -0.63 | 0.0051 | 1 |
| HSA-MIR-629-5P|MIMAT0004810 | 1.1e-06 | -0.63 | 0.000023 | 1 |
| HSA-MIR-140-3P|MIMAT0004597 | 0.0018 | -0.65 | 0.0093 | 1 |
| HSA-MIR-30E-3P|MIMAT0000693 | 0.003 | -0.65 | 0.014 | 1 |
| HSA-MIR-550A-5P|MIMAT0004800 | 0.018 | -0.66 | 0.056 | 1 |
| HSA-MIR-1271-5P|MIMAT0005796 | 0.015 | -0.67 | 0.048 | 1 |
| HSA-MIR-186-5P|MIMAT0000456 | 0.000087 | -0.68 | 0.00081 | 1 |
| HSA-MIR-3136-5P|MIMAT0015003 | 0.037 | -0.68 | 0.1 | 1 |
| HSA-MIR-26A-2-3P|MIMAT0004681 | 0.045 | -0.68 | 0.12 | 1 |
| HSA-MIR-191-5P|MIMAT0000440 | 9.2e-06 | -0.68 | 0.00014 | 1 |
| HSA-MIR-320C|MIMAT0005793 | 0.0078 | -0.7 | 0.03 | 1 |
| HSA-MIR-455-3P|MIMAT0004784 | 0.0033 | -0.71 | 0.015 | 1 |
| HSA-MIR-3158-3P|MIMAT0015032 | 0.014 | -0.72 | 0.046 | 1 |
| HSA-MIR-203A-3P|MIMAT0000264 | 0.038 | -0.75 | 0.11 | 1 |
| HSA-MIR-28-5P|MIMAT0000085 | 3e-06 | -0.75 | 0.000056 | 1 |
| HSA-MIR-92A-3P|MIMAT0000092 | 0.00039 | -0.76 | 0.0025 | 1 |
| HSA-MIR-146A-5P|MIMAT0000449 | 0.00027 | -0.77 | 0.0019 | 1 |
| HSA-MIR-25-3P|MIMAT0000081 | 0.000095 | -0.77 | 0.00087 | 1 |
| HSA-MIR-296-5P|MIMAT0000690 | 0.00092 | -0.79 | 0.0052 | 1 |
| HSA-MIR-29B-2-5P|MIMAT0004515 | 0.00038 | -0.8 | 0.0025 | 1 |
| HSA-MIR-26A-1-3P|MIMAT0004499 | 0.01 | -0.81 | 0.036 | 1 |
| HSA-MIR-378A-3P|MIMAT0000732 | 0.00079 | -0.85 | 0.0046 | 1 |
| HSA-MIR-363-3P|MIMAT0000707 | 0.018 | -0.87 | 0.055 | 1 |
| HSA-MIR-491-5P|MIMAT0002807 | 0.00015 | -0.89 | 0.0013 | 1 |
| HSA-MIR-199B-5P|MIMAT0000263 | 0.0058 | -0.9 | 0.024 | 1 |
| HSA-MIR-605-5P|MIMAT0003273 | 0.011 | -0.91 | 0.039 | 1 |
| HSA-MIR-2114-5P|MIMAT0011156 | 0.0094 | -0.91 | 0.034 | 1 |
| HSA-MIR-548S|MIMAT0014987 | 0.0054 | -0.92 | 0.023 | 1 |
| HSA-MIR-378C|MIMAT0016847 | 0.0022 | -0.94 | 0.011 | 1 |
| HSA-MIR-1226-3P|MIMAT0005577 | 0.0021 | -0.96 | 0.011 | 1 |
| HSA-MIR-1284|MIMAT0005941 | 0.00076 | -0.96 | 0.0045 | 1 |
| HSA-MIR-29C-5P|MIMAT0004673 | 0.000079 | -0.97 | 0.00076 | 1 |
| HSA-LET-7A-2-3P|MIMAT0010195 | 0.02 | -0.97 | 0.062 | 1 |
| HSA-MIR-676-5P|MIMAT0018203 | 0.0047 | -0.97 | 0.021 | 1 |
| HSA-MIR-26B-3P|MIMAT0004500 | 0.000019 | -0.99 | 0.00023 | 1 |
| HSA-MIR-335-3P|MIMAT0004703 | 0.0082 | -1 | 0.032 | 1 |
| HSA-MIR-378A-5P|MIMAT0000731 | 0.000011 | -1 | 0.00015 | 1 |
| HSA-MIR-375|MIMAT0000728 | 0.0026 | -1 | 0.013 | 1 |
| HSA-MIR-191-3P|MIMAT0001618 | 0.000052 | -1 | 0.00056 | 1 |
| HSA-MIR-138-1-3P|MIMAT0004607 | 0.0039 | -1 | 0.018 | 1 |
| HSA-MIR-3150B-3P|MIMAT0018194 | 0.03 | -1 | 0.085 | 1 |
| HSA-MIR-28-3P|MIMAT0004502 | 2.6e-08 | -1 | 1.1e-06 | 1 |
| HSA-MIR-30A-3P|MIMAT0000088 | 0.0018 | -1.1 | 0.0096 | 1 |
| HSA-MIR-320D|MIMAT0006764 | 0.0025 | -1.1 | 0.013 | 1 |
| HSA-MIR-211-5P|MIMAT0000268 | 0.000033 | -1.1 | 0.00037 | 1 |
| HSA-MIR-328-3P|MIMAT0000752 | 0.000098 | -1.1 | 0.00089 | 1 |
| HSA-MIR-30C-1-3P|MIMAT0004674 | 0.000012 | -1.2 | 0.00016 | 1 |
| HSA-MIR-2116-3P|MIMAT0011161 | 0.000016 | -1.2 | 0.0002 | 1 |
| HSA-MIR-1468-5P|MIMAT0006789 | 0.00027 | -1.2 | 0.0019 | 1 |
| HSA-MIR-222-5P|MIMAT0004569 | 0.0031 | -1.2 | 0.015 | 1 |
| HSA-MIR-100-5P|MIMAT0000098 | 0.0021 | -1.2 | 0.011 | 1 |
| HSA-MIR-1910-5P|MIMAT0007884 | 0.00026 | -1.2 | 0.0019 | 1 |
| HSA-MIR-1262|MIMAT0005914 | 2.6e-07 | -1.2 | 7.1e-06 | 1 |
| HSA-MIR-197-3P|MIMAT0000227 | 2.2e-12 | -1.2 | 1.4e-10 | 1 |
| HSA-MIR-1249-3P|MIMAT0005901 | 0.00017 | -1.3 | 0.0013 | 1 |
| HSA-MIR-1248|MIMAT0005900 | 0.00082 | -1.3 | 0.0048 | 1 |
| HSA-MIR-3170|MIMAT0015045 | 0.00024 | -1.3 | 0.0018 | 1 |
| HSA-MIR-20B-3P|MIMAT0004752 | 0.00051 | -1.4 | 0.0032 | 1 |
| HSA-MIR-125B-1-3P|MIMAT0004592 | 0.0022 | -1.4 | 0.011 | 1 |
| HSA-MIR-30C-2-3P|MIMAT0004550 | 1e-05 | -1.4 | 0.00015 | 1 |
| HSA-MIR-221-5P|MIMAT0004568 | 0.0053 | -1.4 | 0.023 | 1 |
| HSA-MIR-181A-5P|MIMAT0000256 | 1.2e-06 | -1.4 | 0.000023 | 1 |
| HSA-MIR-130A-5P|MIMAT0004593 | 0.00057 | -1.4 | 0.0035 | 1 |
| HSA-MIR-181B-5P|MIMAT0000257 | 2.6e-07 | -1.5 | 7.1e-06 | 1 |
| HSA-MIR-219A-1-3P|MIMAT0004567 | 3.1e-07 | -1.5 | 7.8e-06 | 1 |
| HSA-MIR-187-3P|MIMAT0000262 | 0.013 | -1.6 | 0.044 | 1 |
| HSA-MIR-181A-2-3P|MIMAT0004558 | 1e-05 | -1.6 | 0.00015 | 1 |
| HSA-MIR-383-5P|MIMAT0000738 | 0.044 | -1.6 | 0.12 | 1 |
| HSA-MIR-1296-5P|MIMAT0005794 | 0.00016 | -1.6 | 0.0013 | 1 |
| HSA-MIR-222-3P|MIMAT0000279 | 0.00094 | -1.6 | 0.0053 | 1 |
| HSA-MIR-99A-3P|MIMAT0004511 | 0.000015 | -1.6 | 0.00019 | 1 |
| HSA-MIR-3125|MIMAT0014988 | 0.015 | -1.7 | 0.048 | 1 |
| HSA-MIR-873-5P|MIMAT0004953 | 0.000084 | -1.7 | 0.00079 | 1 |
| HSA-MIR-3200-3P|MIMAT0015085 | 0.000016 | -1.8 | 0.0002 | 1 |
| HSA-MIR-125B-5P|MIMAT0000423 | 5.1e-06 | -1.9 | 0.000077 | 1 |
| HSA-MIR-125B-2-3P|MIMAT0004603 | 4.2e-06 | -2 | 0.000071 | 1 |
| HSA-MIR-99A-5P|MIMAT0000097 | 4.8e-07 | -2.1 | 0.000011 | 1 |
| HSA-MIR-221-3P|MIMAT0000278 | 0.00017 | -2.1 | 0.0013 | 1 |
| HSA-LET-7C-5P|MIMAT0000064 | 5.7e-08 | -2.2 | 2.1e-06 | 1 |
| HSA-MIR-548V|MIMAT0015020 | 3.1e-06 | -2.5 | 0.000056 | 1 |
| HSA-MIR-1270|MIMAT0005924 | 2e-07 | -2.7 | 6.6e-06 | 1 |
| HSA-MIR-935|MIMAT0004978 | 7.6e-08 | -2.8 | 2.7e-06 | 1 |
| HSA-MIR-514B-5P|MIMAT0015087 | 6.1e-10 | -4 | 3.1e-08 | 1 |
| HSA-MIR-513B-5P|MIMAT0005788 | 1.5e-09 | -4.2 | 6.7e-08 | 1 |
| HSA-MIR-514A-3P|MIMAT0002883 | 2.9e-13 | -4.5 | 4e-11 | 1 |
| HSA-MIR-513A-5P|MIMAT0002877 | 1.8e-12 | -4.6 | 1.3e-10 | 1 |
| HSA-MIR-509-3-5P|MIMAT0004975 | 4e-13 | -4.9 | 4e-11 | 1 |
| HSA-MIR-508-5P|MIMAT0004778 | 3.6e-13 | -5 | 4e-11 | 1 |
| HSA-MIR-506-3P|MIMAT0002878 | 2.9e-14 | -5 | 5.7e-12 | 1 |
| HSA-MIR-509-3P|MIMAT0002881 | 1.7e-14 | -5 | 5e-12 | 1 |
| HSA-MIR-508-3P|MIMAT0002880 | 6.8e-15 | -5.1 | 4.1e-12 | 1 |
| HSA-MIR-513C-5P|MIMAT0005789 | 1.1e-12 | -5.1 | 9.8e-11 | 1 |
| HSA-MIR-124-3P|MIMAT0000422 | 0.014 | 2.7 | 0.071 | 2 |
| HSA-MIR-1247-5P|MIMAT0005899 | 0.0026 | 2.2 | 0.025 | 2 |
| HSA-MIR-105-5P|MIMAT0000102 | 0.037 | 1.9 | 0.13 | 2 |
| HSA-MIR-199A-3P|MIMAT0000232 | 0.00093 | 1.9 | 0.014 | 2 |
| HSA-MIR-199B-3P|MIMAT0004563 | 0.00095 | 1.9 | 0.014 | 2 |
| HSA-MIR-204-5P|MIMAT0000265 | 0.0075 | 1.9 | 0.048 | 2 |
| HSA-MIR-217|MIMAT0000274 | 0.0065 | 1.9 | 0.045 | 2 |
| HSA-MIR-183-5P|MIMAT0000261 | 0.02 | 1.8 | 0.089 | 2 |
| HSA-MIR-433-3P|MIMAT0001627 | 0.00056 | 1.8 | 0.012 | 2 |
| HSA-MIR-182-5P|MIMAT0000259 | 0.013 | 1.8 | 0.067 | 2 |
| HSA-MIR-199A-5P|MIMAT0000231 | 0.0021 | 1.8 | 0.022 | 2 |
| HSA-MIR-767-5P|MIMAT0003882 | 0.041 | 1.8 | 0.14 | 2 |
| HSA-MIR-134-5P|MIMAT0000447 | 0.00027 | 1.8 | 0.0078 | 2 |
| HSA-MIR-539-5P|MIMAT0003163 | 0.0011 | 1.7 | 0.014 | 2 |
| HSA-MIR-129-2-3P|MIMAT0004605 | 0.00029 | 1.7 | 0.0079 | 2 |
| HSA-MIR-383-5P|MIMAT0000738 | 0.029 | 1.7 | 0.11 | 2 |
| HSA-MIR-96-5P|MIMAT0000095 | 0.038 | 1.6 | 0.13 | 2 |
| HSA-MIR-382-5P|MIMAT0000737 | 0.0014 | 1.6 | 0.016 | 2 |
| HSA-MIR-346|MIMAT0000773 | 1.3e-06 | 1.6 | 0.00077 | 2 |
| HSA-MIR-154-5P|MIMAT0000452 | 0.0012 | 1.5 | 0.014 | 2 |
| HSA-MIR-379-5P|MIMAT0000733 | 0.00097 | 1.5 | 0.014 | 2 |
| HSA-MIR-127-3P|MIMAT0000446 | 0.0014 | 1.5 | 0.016 | 2 |
| HSA-MIR-937-3P|MIMAT0004980 | 0.00069 | 1.5 | 0.012 | 2 |
| HSA-MIR-184|MIMAT0000454 | 0.00058 | 1.5 | 0.012 | 2 |
| HSA-MIR-9-5P|MIMAT0000441 | 0.038 | 1.5 | 0.13 | 2 |
| HSA-MIR-375|MIMAT0000728 | 0.001 | 1.5 | 0.014 | 2 |
| HSA-MIR-323B-3P|MIMAT0015050 | 0.014 | 1.4 | 0.07 | 2 |
| HSA-MIR-1275|MIMAT0005929 | 0.00067 | 1.4 | 0.012 | 2 |
| HSA-MIR-431-3P|MIMAT0004757 | 0.0097 | 1.4 | 0.056 | 2 |
| HSA-MIR-362-5P|MIMAT0000705 | 0.00047 | 1.3 | 0.011 | 2 |
| HSA-MIR-708-3P|MIMAT0004927 | 0.0048 | 1.3 | 0.036 | 2 |
| HSA-MIR-758-3P|MIMAT0003879 | 0.0025 | 1.3 | 0.024 | 2 |
| HSA-MIR-143-5P|MIMAT0004599 | 0.000025 | 1.3 | 0.0017 | 2 |
| HSA-MIR-432-5P|MIMAT0002814 | 0.0077 | 1.3 | 0.049 | 2 |
| HSA-MIR-145-3P|MIMAT0004601 | 0.000029 | 1.2 | 0.0017 | 2 |
| HSA-MIR-487B-3P|MIMAT0003180 | 0.016 | 1.2 | 0.076 | 2 |
| HSA-MIR-891A-5P|MIMAT0004902 | 0.0073 | 1.2 | 0.048 | 2 |
| HSA-MIR-493-5P|MIMAT0002813 | 0.0007 | 1.2 | 0.012 | 2 |
| HSA-MIR-409-3P|MIMAT0001639 | 0.0028 | 1.2 | 0.026 | 2 |
| HSA-MIR-136-5P|MIMAT0000448 | 0.017 | 1.2 | 0.079 | 2 |
| HSA-MIR-370-3P|MIMAT0000722 | 0.011 | 1.2 | 0.059 | 2 |
| HSA-MIR-887-3P|MIMAT0004951 | 0.01 | 1.2 | 0.059 | 2 |
| HSA-MIR-409-5P|MIMAT0001638 | 0.009 | 1.1 | 0.053 | 2 |
| HSA-MIR-149-5P|MIMAT0000450 | 4.3e-06 | 1.1 | 0.0013 | 2 |
| HSA-MIR-143-3P|MIMAT0000435 | 0.000088 | 1.1 | 0.0038 | 2 |
| HSA-MIR-127-5P|MIMAT0004604 | 0.027 | 1.1 | 0.11 | 2 |
| HSA-MIR-129-5P|MIMAT0000242 | 0.00071 | 1.1 | 0.012 | 2 |
| HSA-MIR-708-5P|MIMAT0004926 | 0.019 | 1.1 | 0.088 | 2 |
| HSA-MIR-489-3P|MIMAT0002805 | 0.036 | 1.1 | 0.13 | 2 |
| HSA-MIR-216A-5P|MIMAT0000273 | 0.04 | 1 | 0.14 | 2 |
| HSA-MIR-200A-5P|MIMAT0001620 | 0.0032 | 1 | 0.028 | 2 |
| HSA-MIR-206|MIMAT0000462 | 0.022 | 1 | 0.093 | 2 |
| HSA-MIR-3651|MIMAT0018071 | 0.002 | 1 | 0.021 | 2 |
| HSA-MIR-99B-3P|MIMAT0004678 | 0.00019 | 1 | 0.0061 | 2 |
| HSA-MIR-145-5P|MIMAT0000437 | 0.0011 | 0.95 | 0.014 | 2 |
| HSA-MIR-543|MIMAT0004954 | 0.019 | 0.95 | 0.087 | 2 |
| HSA-MIR-369-5P|MIMAT0001621 | 0.037 | 0.95 | 0.13 | 2 |
| HSA-MIR-200B-5P|MIMAT0004571 | 0.012 | 0.92 | 0.063 | 2 |
| HSA-MIR-214-5P|MIMAT0004564 | 0.0044 | 0.91 | 0.034 | 2 |
| HSA-MIR-496|MIMAT0002818 | 0.035 | 0.9 | 0.13 | 2 |
| HSA-MIR-3183|MIMAT0015063 | 0.0039 | 0.89 | 0.032 | 2 |
| HSA-MIR-760|MIMAT0004957 | 0.0032 | 0.87 | 0.028 | 2 |
| HSA-MIR-3198|MIMAT0015083 | 0.04 | 0.87 | 0.14 | 2 |
| HSA-MIR-139-3P|MIMAT0004552 | 0.0013 | 0.86 | 0.016 | 2 |
| HSA-MIR-3622A-3P|MIMAT0018004 | 0.023 | 0.86 | 0.096 | 2 |
| HSA-MIR-337-3P|MIMAT0000754 | 0.039 | 0.85 | 0.14 | 2 |
| HSA-MIR-218-5P|MIMAT0000275 | 0.00068 | 0.84 | 0.012 | 2 |
| HSA-MIR-511-5P|MIMAT0002808 | 0.018 | 0.83 | 0.084 | 2 |
| HSA-MIR-155-5P|MIMAT0000646 | 0.039 | 0.82 | 0.14 | 2 |
| HSA-MIR-940|MIMAT0004983 | 0.0044 | 0.8 | 0.034 | 2 |
| HSA-MIR-877-5P|MIMAT0004949 | 0.019 | 0.77 | 0.087 | 2 |
| HSA-MIR-7-5P|MIMAT0000252 | 0.02 | 0.77 | 0.089 | 2 |
| HSA-MIR-326|MIMAT0000756 | 0.031 | 0.76 | 0.12 | 2 |
| HSA-MIR-627-5P|MIMAT0003296 | 0.023 | 0.76 | 0.096 | 2 |
| HSA-MIR-200B-3P|MIMAT0000318 | 0.011 | 0.72 | 0.062 | 2 |
| HSA-MIR-193A-5P|MIMAT0004614 | 0.00054 | 0.72 | 0.012 | 2 |
| HSA-MIR-146B-5P|MIMAT0002809 | 0.021 | 0.71 | 0.092 | 2 |
| HSA-MIR-212-3P|MIMAT0000269 | 0.0082 | 0.7 | 0.05 | 2 |
| HSA-MIR-421|MIMAT0003339 | 0.021 | 0.69 | 0.092 | 2 |
| HSA-MIR-345-5P|MIMAT0000772 | 0.0028 | 0.68 | 0.025 | 2 |
| HSA-MIR-1248|MIMAT0005900 | 0.026 | 0.66 | 0.11 | 2 |
| HSA-MIR-99B-5P|MIMAT0000689 | 0.0074 | 0.64 | 0.048 | 2 |
| HSA-MIR-328-3P|MIMAT0000752 | 0.02 | 0.63 | 0.089 | 2 |
| HSA-MIR-22-5P|MIMAT0004495 | 0.0072 | 0.62 | 0.048 | 2 |
| HSA-MIR-146B-3P|MIMAT0004766 | 0.015 | 0.6 | 0.073 | 2 |
| HSA-LET-7B-5P|MIMAT0000063 | 0.012 | 0.59 | 0.064 | 2 |
| HSA-MIR-26B-5P|MIMAT0000083 | 0.0039 | 0.59 | 0.032 | 2 |
| HSA-MIR-132-5P|MIMAT0004594 | 0.0042 | 0.59 | 0.034 | 2 |
| HSA-MIR-24-1-5P|MIMAT0000079 | 0.0083 | 0.58 | 0.05 | 2 |
| HSA-MIR-330-5P|MIMAT0004693 | 0.04 | 0.58 | 0.14 | 2 |
| HSA-MIR-27B-5P|MIMAT0004588 | 0.0043 | 0.57 | 0.034 | 2 |
| HSA-MIR-125A-3P|MIMAT0004602 | 0.017 | 0.56 | 0.079 | 2 |
| HSA-MIR-128-3P|MIMAT0000424 | 0.00066 | 0.54 | 0.012 | 2 |
| HSA-MIR-1301-3P|MIMAT0005797 | 0.0081 | 0.54 | 0.05 | 2 |
| HSA-MIR-491-5P|MIMAT0002807 | 0.039 | 0.53 | 0.14 | 2 |
| HSA-MIR-1976|MIMAT0009451 | 0.028 | 0.53 | 0.11 | 2 |
| HSA-MIR-331-5P|MIMAT0004700 | 0.011 | 0.52 | 0.059 | 2 |
| HSA-MIR-1254|MIMAT0005905 | 0.032 | 0.51 | 0.12 | 2 |
| HSA-MIR-501-3P|MIMAT0004774 | 0.048 | 0.5 | 0.15 | 2 |
| HSA-LET-7E-5P|MIMAT0000066 | 0.021 | 0.47 | 0.092 | 2 |
| HSA-MIR-98-5P|MIMAT0000096 | 0.0032 | 0.47 | 0.028 | 2 |
| HSA-MIR-29B-1-5P|MIMAT0004514 | 0.029 | 0.46 | 0.11 | 2 |
| HSA-MIR-92B-3P|MIMAT0003218 | 0.022 | 0.45 | 0.094 | 2 |
| HSA-MIR-628-5P|MIMAT0004809 | 0.043 | 0.43 | 0.14 | 2 |
| HSA-MIR-1307-3P|MIMAT0005951 | 0.034 | 0.43 | 0.13 | 2 |
| HSA-MIR-27B-3P|MIMAT0000419 | 0.015 | 0.42 | 0.075 | 2 |
| HSA-MIR-664A-5P|MIMAT0005948 | 0.013 | 0.41 | 0.064 | 2 |
| HSA-MIR-30B-3P|MIMAT0004589 | 0.046 | 0.39 | 0.15 | 2 |
| HSA-MIR-423-3P|MIMAT0001340 | 0.031 | 0.35 | 0.12 | 2 |
| HSA-MIR-769-5P|MIMAT0003886 | 0.047 | -0.35 | 0.15 | 2 |
| HSA-MIR-181A-5P|MIMAT0000256 | 0.04 | -0.41 | 0.14 | 2 |
| HSA-MIR-589-3P|MIMAT0003256 | 0.045 | -0.52 | 0.15 | 2 |
| HSA-MIR-500B-5P|MIMAT0016925 | 0.04 | -0.53 | 0.14 | 2 |
| HSA-MIR-500A-5P|MIMAT0004773 | 0.04 | -0.53 | 0.14 | 2 |
| HSA-MIR-643|MIMAT0003313 | 0.011 | -0.56 | 0.062 | 2 |
| HSA-MIR-30C-5P|MIMAT0000244 | 0.0083 | -0.57 | 0.05 | 2 |
| HSA-MIR-15A-5P|MIMAT0000068 | 0.046 | -0.59 | 0.15 | 2 |
| HSA-MIR-28-5P|MIMAT0000085 | 0.0074 | -0.6 | 0.048 | 2 |
| HSA-MIR-20B-5P|MIMAT0001413 | 0.046 | -0.61 | 0.15 | 2 |
| HSA-MIR-30B-5P|MIMAT0000420 | 0.012 | -0.63 | 0.063 | 2 |
| HSA-MIR-3065-3P|MIMAT0015378 | 0.02 | -0.64 | 0.09 | 2 |
| HSA-MIR-331-3P|MIMAT0000760 | 0.03 | -0.64 | 0.12 | 2 |
| HSA-MIR-374B-3P|MIMAT0004956 | 0.015 | -0.66 | 0.072 | 2 |
| HSA-MIR-942-5P|MIMAT0004985 | 0.0024 | -0.67 | 0.024 | 2 |
| HSA-MIR-548O-3P|MIMAT0005919 | 0.023 | -0.67 | 0.096 | 2 |
| HSA-MIR-181C-5P|MIMAT0000258 | 0.024 | -0.7 | 0.098 | 2 |
| HSA-MIR-106B-5P|MIMAT0000680 | 0.0096 | -0.7 | 0.055 | 2 |
| HSA-MIR-148A-3P|MIMAT0000243 | 0.0073 | -0.71 | 0.048 | 2 |
| HSA-MIR-1271-5P|MIMAT0005796 | 0.043 | -0.71 | 0.14 | 2 |
| HSA-MIR-194-3P|MIMAT0004671 | 0.0065 | -0.72 | 0.045 | 2 |
| HSA-MIR-34B-3P|MIMAT0004676 | 0.028 | -0.74 | 0.11 | 2 |
| HSA-MIR-455-5P|MIMAT0003150 | 0.012 | -0.77 | 0.063 | 2 |
| HSA-MIR-374B-5P|MIMAT0004955 | 0.02 | -0.79 | 0.089 | 2 |
| HSA-MIR-29B-3P|MIMAT0000100 | 0.0049 | -0.79 | 0.036 | 2 |
| HSA-MIR-2355-5P|MIMAT0016895 | 0.039 | -0.82 | 0.14 | 2 |
| HSA-MIR-20A-3P|MIMAT0004493 | 0.022 | -0.84 | 0.093 | 2 |
| HSA-MIR-106A-5P|MIMAT0000103 | 0.01 | -0.84 | 0.059 | 2 |
| HSA-MIR-126-5P|MIMAT0000444 | 0.015 | -0.89 | 0.073 | 2 |
| HSA-MIR-34C-3P|MIMAT0004677 | 0.031 | -0.89 | 0.12 | 2 |
| HSA-MIR-192-5P|MIMAT0000222 | 0.000032 | -0.96 | 0.0017 | 2 |
| HSA-MIR-140-3P|MIMAT0004597 | 0.00041 | -0.97 | 0.01 | 2 |
| HSA-MIR-34C-5P|MIMAT0000686 | 0.036 | -0.98 | 0.13 | 2 |
| HSA-LET-7G-3P|MIMAT0004584 | 0.0079 | -0.98 | 0.049 | 2 |
| HSA-MIR-424-5P|MIMAT0001341 | 0.0062 | -1 | 0.044 | 2 |
| HSA-MIR-18A-5P|MIMAT0000072 | 0.006 | -1 | 0.043 | 2 |
| HSA-MIR-192-3P|MIMAT0004543 | 0.0049 | -1 | 0.036 | 2 |
| HSA-MIR-140-5P|MIMAT0000431 | 0.002 | -1 | 0.021 | 2 |
| HSA-MIR-155-3P|MIMAT0004658 | 0.031 | -1 | 0.12 | 2 |
| HSA-MIR-340-5P|MIMAT0004692 | 0.006 | -1 | 0.043 | 2 |
| HSA-MIR-590-3P|MIMAT0004801 | 0.0095 | -1 | 0.055 | 2 |
| HSA-MIR-503-5P|MIMAT0002874 | 0.004 | -1.1 | 0.033 | 2 |
| HSA-MIR-29C-3P|MIMAT0000681 | 0.0011 | -1.1 | 0.014 | 2 |
| HSA-MIR-590-5P|MIMAT0003258 | 0.0022 | -1.1 | 0.022 | 2 |
| HSA-MIR-142-5P|MIMAT0000433 | 0.036 | -1.1 | 0.13 | 2 |
| HSA-MIR-624-5P|MIMAT0003293 | 0.001 | -1.1 | 0.014 | 2 |
| HSA-MIR-142-3P|MIMAT0000434 | 0.036 | -1.1 | 0.13 | 2 |
| HSA-MIR-20A-5P|MIMAT0000075 | 0.0031 | -1.2 | 0.028 | 2 |
| HSA-MIR-1277-3P|MIMAT0005933 | 0.00013 | -1.2 | 0.005 | 2 |
| HSA-MIR-32-5P|MIMAT0000090 | 0.012 | -1.2 | 0.063 | 2 |
| HSA-MIR-30A-5P|MIMAT0000087 | 0.00024 | -1.2 | 0.0072 | 2 |
| HSA-MIR-302B-3P|MIMAT0000715 | 0.0051 | -1.3 | 0.037 | 2 |
| HSA-MIR-130A-3P|MIMAT0000425 | 0.000057 | -1.3 | 0.0029 | 2 |
| HSA-MIR-362-3P|MIMAT0004683 | 0.000015 | -1.3 | 0.0016 | 2 |
| HSA-MIR-101-5P|MIMAT0004513 | 8e-05 | -1.3 | 0.0037 | 2 |
| HSA-MIR-374A-3P|MIMAT0004688 | 0.00071 | -1.3 | 0.012 | 2 |
| HSA-MIR-651-5P|MIMAT0003321 | 0.0014 | -1.3 | 0.016 | 2 |
| HSA-MIR-30E-5P|MIMAT0000692 | 0.000021 | -1.4 | 0.0017 | 2 |
| HSA-MIR-19B-3P|MIMAT0000074 | 0.00015 | -1.4 | 0.0051 | 2 |
| HSA-MIR-194-5P|MIMAT0000460 | 7.3e-06 | -1.4 | 0.0015 | 2 |
| HSA-MIR-219A-5P|MIMAT0000276 | 0.00067 | -1.5 | 0.012 | 2 |
| HSA-MIR-548V|MIMAT0015020 | 0.0015 | -1.6 | 0.017 | 2 |
| HSA-MIR-506-3P|MIMAT0002878 | 0.028 | -1.6 | 0.11 | 2 |
| HSA-MIR-101-3P|MIMAT0000099 | 0.00037 | -1.6 | 0.0097 | 2 |
| HSA-MIR-301A-3P|MIMAT0000688 | 0.000027 | -2 | 0.0017 | 2 |
| HSA-MIR-509-3-5P|MIMAT0004975 | 0.0082 | -2.1 | 0.05 | 2 |
| HSA-MIR-513C-5P|MIMAT0005789 | 0.0027 | -2.2 | 0.025 | 2 |
| HSA-MIR-509-3P|MIMAT0002881 | 0.0038 | -2.2 | 0.032 | 2 |
| HSA-MIR-514A-3P|MIMAT0002883 | 0.0013 | -2.3 | 0.016 | 2 |
| HSA-MIR-509-5P|MIMAT0004779 | 0.00052 | -2.3 | 0.012 | 2 |
| HSA-MIR-508-3P|MIMAT0002880 | 0.0025 | -2.3 | 0.024 | 2 |
| HSA-MIR-507|MIMAT0002879 | 0.0073 | -2.3 | 0.048 | 2 |
| HSA-MIR-513B-5P|MIMAT0005788 | 0.00016 | -2.5 | 0.0053 | 2 |
| HSA-MIR-374A-5P|MIMAT0000727 | 0.000016 | -2.5 | 0.0016 | 2 |
| HSA-MIR-19A-3P|MIMAT0000073 | 0.00014 | -2.5 | 0.0051 | 2 |
| HSA-MIR-513A-5P|MIMAT0002877 | 0.0011 | -2.6 | 0.014 | 2 |
| HSA-MIR-508-5P|MIMAT0004778 | 0.002 | -2.6 | 0.021 | 2 |
| HSA-MIR-514B-5P|MIMAT0015087 | 0.00076 | -2.6 | 0.012 | 2 |
| HSA-MIR-514B-3P|MIMAT0015088 | 1e-05 | -2.8 | 0.0015 | 2 |
| HSA-MIR-935|MIMAT0004978 | 0.00018 | 3.3 | 0.0055 | 3 |
| HSA-MIR-203A-3P|MIMAT0000264 | 0.000016 | 2.9 | 0.00099 | 3 |
| HSA-MIR-34B-3P|MIMAT0004676 | 0.041 | 2.2 | 0.21 | 3 |
| HSA-MIR-34C-5P|MIMAT0000686 | 0.033 | 2.1 | 0.19 | 3 |
| HSA-MIR-3125|MIMAT0014988 | 0.02 | 2 | 0.14 | 3 |
| HSA-MIR-618|MIMAT0003287 | 0.0018 | 2 | 0.032 | 3 |
| HSA-MIR-125B-1-3P|MIMAT0004592 | 0.0011 | 1.9 | 0.025 | 3 |
| HSA-MIR-129-1-3P|MIMAT0004548 | 0.0016 | 1.9 | 0.032 | 3 |
| HSA-MIR-548V|MIMAT0015020 | 3.6e-06 | 1.8 | 0.0004 | 3 |
| HSA-MIR-548B-5P|MIMAT0004798 | 0.011 | 1.7 | 0.097 | 3 |
| HSA-MIR-181A-3P|MIMAT0000270 | 0.022 | 1.6 | 0.15 | 3 |
| HSA-MIR-582-3P|MIMAT0004797 | 0.013 | 1.6 | 0.11 | 3 |
| HSA-MIR-211-5P|MIMAT0000268 | 0.0017 | 1.6 | 0.032 | 3 |
| HSA-MIR-34B-5P|MIMAT0000685 | 0.029 | 1.6 | 0.18 | 3 |
| HSA-MIR-125B-5P|MIMAT0000423 | 3.6e-10 | 1.5 | 1e-07 | 3 |
| HSA-MIR-548B-3P|MIMAT0003254 | 0.00017 | 1.5 | 0.0055 | 3 |
| HSA-MIR-378C|MIMAT0016847 | 0.000032 | 1.4 | 0.0015 | 3 |
| HSA-MIR-3200-3P|MIMAT0015085 | 0.018 | 1.4 | 0.14 | 3 |
| HSA-MIR-99A-3P|MIMAT0004511 | 0.00077 | 1.4 | 0.02 | 3 |
| HSA-MIR-20B-5P|MIMAT0001413 | 0.014 | 1.3 | 0.11 | 3 |
| HSA-MIR-548O-3P|MIMAT0005919 | 0.01 | 1.3 | 0.092 | 3 |
| HSA-MIR-219A-1-3P|MIMAT0004567 | 3.2e-10 | 1.3 | 1e-07 | 3 |
| HSA-MIR-181C-5P|MIMAT0000258 | 0.004 | 1.2 | 0.049 | 3 |
| HSA-MIR-125B-2-3P|MIMAT0004603 | 8e-06 | 1.2 | 0.00076 | 3 |
| HSA-MIR-29B-2-5P|MIMAT0004515 | 0.0052 | 1.2 | 0.055 | 3 |
| HSA-MIR-1249-3P|MIMAT0005901 | 0.0034 | 1.2 | 0.047 | 3 |
| HSA-MIR-30A-5P|MIMAT0000087 | 0.021 | 1.2 | 0.14 | 3 |
| HSA-MIR-3170|MIMAT0015045 | 0.000015 | 1.2 | 0.00099 | 3 |
| HSA-MIR-4326|MIMAT0016888 | 0.0042 | 1.2 | 0.049 | 3 |
| HSA-MIR-221-5P|MIMAT0004568 | 0.000014 | 1.2 | 0.00099 | 3 |
| HSA-MIR-1285-3P|MIMAT0005876 | 0.019 | 1.2 | 0.14 | 3 |
| HSA-MIR-1271-5P|MIMAT0005796 | 2.8e-06 | 1.1 | 0.00039 | 3 |
| HSA-MIR-181D-5P|MIMAT0002821 | 0.0035 | 1.1 | 0.047 | 3 |
| HSA-MIR-29C-3P|MIMAT0000681 | 0.0043 | 1.1 | 0.049 | 3 |
| HSA-MIR-34A-3P|MIMAT0004557 | 0.00012 | 1.1 | 0.0046 | 3 |
| HSA-MIR-30C-2-3P|MIMAT0004550 | 0.00071 | 1.1 | 0.019 | 3 |
| HSA-MIR-99A-5P|MIMAT0000097 | 0.0025 | 1.1 | 0.041 | 3 |
| HSA-MIR-26A-1-3P|MIMAT0004499 | 0.000038 | 1 | 0.0016 | 3 |
| HSA-MIR-222-3P|MIMAT0000279 | 0.0013 | 1 | 0.029 | 3 |
| HSA-MIR-34A-5P|MIMAT0000255 | 0.016 | 1 | 0.12 | 3 |
| HSA-MIR-181C-3P|MIMAT0004559 | 0.004 | 1 | 0.049 | 3 |
| HSA-MIR-30A-3P|MIMAT0000088 | 0.033 | 1 | 0.19 | 3 |
| HSA-MIR-181A-5P|MIMAT0000256 | 0.033 | 0.99 | 0.19 | 3 |
| HSA-LET-7G-3P|MIMAT0004584 | 0.019 | 0.96 | 0.14 | 3 |
| HSA-MIR-296-3P|MIMAT0004679 | 0.041 | 0.96 | 0.21 | 3 |
| HSA-MIR-1468-5P|MIMAT0006789 | 0.013 | 0.93 | 0.11 | 3 |
| HSA-MIR-193B-5P|MIMAT0004767 | 0.0042 | 0.93 | 0.049 | 3 |
| HSA-MIR-589-3P|MIMAT0003256 | 0.025 | 0.91 | 0.16 | 3 |
| HSA-MIR-874-3P|MIMAT0004911 | 0.014 | 0.87 | 0.11 | 3 |
| HSA-MIR-30C-5P|MIMAT0000244 | 0.03 | 0.85 | 0.18 | 3 |
| HSA-MIR-3909|MIMAT0018183 | 0.037 | 0.81 | 0.21 | 3 |
| HSA-MIR-378A-3P|MIMAT0000732 | 0.0027 | 0.8 | 0.042 | 3 |
| HSA-MIR-101-5P|MIMAT0004513 | 0.039 | 0.78 | 0.21 | 3 |
| HSA-MIR-221-3P|MIMAT0000278 | 0.022 | 0.78 | 0.15 | 3 |
| HSA-MIR-30C-1-3P|MIMAT0004674 | 0.0035 | 0.77 | 0.047 | 3 |
| HSA-MIR-130A-3P|MIMAT0000425 | 0.0032 | 0.76 | 0.046 | 3 |
| HSA-MIR-28-3P|MIMAT0004502 | 0.00014 | 0.74 | 0.0048 | 3 |
| HSA-MIR-29C-5P|MIMAT0004673 | 0.026 | 0.74 | 0.16 | 3 |
| HSA-MIR-589-5P|MIMAT0004799 | 0.012 | 0.72 | 0.11 | 3 |
| HSA-MIR-192-5P|MIMAT0000222 | 0.0018 | 0.71 | 0.032 | 3 |
| HSA-MIR-148A-3P|MIMAT0000243 | 0.00021 | 0.7 | 0.0063 | 3 |
| HSA-MIR-942-5P|MIMAT0004985 | 0.013 | 0.7 | 0.11 | 3 |
| HSA-MIR-625-3P|MIMAT0004808 | 0.027 | 0.69 | 0.17 | 3 |
| HSA-LET-7C-5P|MIMAT0000064 | 0.0027 | 0.69 | 0.042 | 3 |
| HSA-MIR-378A-5P|MIMAT0000731 | 0.0031 | 0.67 | 0.046 | 3 |
| HSA-MIR-616-5P|MIMAT0003284 | 0.0057 | 0.66 | 0.058 | 3 |
| HSA-MIR-194-5P|MIMAT0000460 | 0.041 | 0.66 | 0.22 | 3 |
| HSA-MIR-374B-3P|MIMAT0004956 | 0.011 | 0.66 | 0.1 | 3 |
| HSA-MIR-19B-1-5P|MIMAT0004491 | 0.018 | 0.65 | 0.14 | 3 |
| HSA-LET-7G-5P|MIMAT0000414 | 0.00092 | 0.64 | 0.022 | 3 |
| HSA-MIR-550A-5P|MIMAT0004800 | 0.05 | 0.63 | 0.23 | 3 |
| HSA-MIR-301A-3P|MIMAT0000688 | 0.023 | 0.63 | 0.15 | 3 |
| HSA-MIR-30E-3P|MIMAT0000693 | 0.00034 | 0.62 | 0.0096 | 3 |
| HSA-MIR-186-5P|MIMAT0000456 | 0.0045 | 0.6 | 0.049 | 3 |
| HSA-MIR-502-5P|MIMAT0002873 | 0.049 | 0.58 | 0.23 | 3 |
| HSA-MIR-616-3P|MIMAT0004805 | 0.0068 | 0.57 | 0.067 | 3 |
| HSA-MIR-1179|MIMAT0005824 | 0.037 | 0.56 | 0.21 | 3 |
| HSA-MIR-28-5P|MIMAT0000085 | 0.005 | 0.56 | 0.054 | 3 |
| HSA-MIR-3189-3P|MIMAT0015071 | 0.018 | 0.55 | 0.14 | 3 |
| HSA-MIR-331-3P|MIMAT0000760 | 0.05 | 0.55 | 0.23 | 3 |
| HSA-MIR-574-3P|MIMAT0003239 | 0.0024 | 0.54 | 0.041 | 3 |
| HSA-MIR-339-3P|MIMAT0004702 | 0.0038 | 0.54 | 0.048 | 3 |
| HSA-LET-7I-3P|MIMAT0004585 | 0.042 | 0.48 | 0.22 | 3 |
| HSA-MIR-361-5P|MIMAT0000703 | 0.036 | 0.43 | 0.21 | 3 |
| HSA-MIR-197-3P|MIMAT0000227 | 0.049 | 0.38 | 0.23 | 3 |
| HSA-MIR-93-5P|MIMAT0000093 | 0.0075 | -0.34 | 0.072 | 3 |
| HSA-MIR-151A-5P|MIMAT0004697 | 0.0084 | -0.4 | 0.081 | 3 |
| HSA-MIR-3679-5P|MIMAT0018104 | 0.0055 | -0.5 | 0.058 | 3 |
| HSA-MIR-151A-3P|MIMAT0000757 | 0.023 | -0.53 | 0.15 | 3 |
| HSA-MIR-30D-3P|MIMAT0004551 | 0.014 | -0.6 | 0.11 | 3 |
| HSA-MIR-199B-5P|MIMAT0000263 | 0.0096 | -0.64 | 0.09 | 3 |
| HSA-MIR-330-5P|MIMAT0004693 | 0.039 | -0.65 | 0.21 | 3 |
| HSA-MIR-132-5P|MIMAT0004594 | 0.046 | -0.66 | 0.23 | 3 |
| HSA-MIR-145-5P|MIMAT0000437 | 0.046 | -0.69 | 0.23 | 3 |
| HSA-MIR-7-5P|MIMAT0000252 | 0.028 | -0.72 | 0.17 | 3 |
| HSA-MIR-129-2-3P|MIMAT0004605 | 0.04 | -0.74 | 0.21 | 3 |
| HSA-MIR-362-5P|MIMAT0000705 | 0.049 | -0.82 | 0.23 | 3 |
| HSA-LET-7B-5P|MIMAT0000063 | 0.048 | -0.82 | 0.23 | 3 |
| HSA-MIR-212-3P|MIMAT0000269 | 0.045 | -0.83 | 0.23 | 3 |
| HSA-MIR-21-5P|MIMAT0000076 | 0.039 | -0.87 | 0.21 | 3 |
| HSA-MIR-32-3P|MIMAT0004505 | 0.00088 | -0.87 | 0.022 | 3 |
| HSA-MIR-433-3P|MIMAT0001627 | 0.043 | -1 | 0.22 | 3 |
| HSA-MIR-758-3P|MIMAT0003879 | 0.02 | -1 | 0.14 | 3 |
| HSA-MIR-301B-3P|MIMAT0004958 | 1.7e-06 | -1 | 0.00032 | 3 |
| HSA-MIR-577|MIMAT0003242 | 0.026 | -1 | 0.16 | 3 |
| HSA-MIR-143-3P|MIMAT0000435 | 0.049 | -1.2 | 0.23 | 3 |
| HSA-MIR-196A-5P|MIMAT0000226 | 0.04 | -1.4 | 0.21 | 3 |
| HSA-MIR-124-5P|MIMAT0004591 | 0.0036 | -1.4 | 0.047 | 3 |
| HSA-MIR-513B-5P|MIMAT0005788 | 0.021 | -1.5 | 0.14 | 3 |
| HSA-MIR-708-5P|MIMAT0004926 | 0.0068 | -1.5 | 0.067 | 3 |
| HSA-MIR-379-5P|MIMAT0000733 | 0.047 | -1.6 | 0.23 | 3 |
| HSA-MIR-10B-3P|MIMAT0004556 | 0.0016 | -1.6 | 0.032 | 3 |
| HSA-MIR-940|MIMAT0004983 | 0.0044 | -1.7 | 0.049 | 3 |
| HSA-MIR-539-5P|MIMAT0003163 | 0.021 | -1.8 | 0.14 | 3 |
| HSA-MIR-592|MIMAT0003260 | 0.015 | -2 | 0.12 | 3 |
| HSA-MIR-509-5P|MIMAT0004779 | 0.003 | -2.1 | 0.046 | 3 |
| HSA-MIR-937-3P|MIMAT0004980 | 0.0097 | -2.2 | 0.09 | 3 |
| HSA-MIR-199B-3P|MIMAT0004563 | 0.000022 | -2.4 | 0.0011 | 3 |
| HSA-MIR-199A-3P|MIMAT0000232 | 0.000022 | -2.4 | 0.0011 | 3 |
| HSA-MIR-196B-5P|MIMAT0001080 | 0.0024 | -2.6 | 0.041 | 3 |
| HSA-MIR-199A-5P|MIMAT0000231 | 0.00012 | -2.6 | 0.0046 | 3 |
| HSA-MIR-514A-3P|MIMAT0002883 | 3.5e-11 | 5.2 | 7e-09 | 4 |
| HSA-MIR-508-5P|MIMAT0004778 | 4.9e-11 | 5.1 | 7.3e-09 | 4 |
| HSA-MIR-508-3P|MIMAT0002880 | 1.6e-11 | 5 | 4.7e-09 | 4 |
| HSA-MIR-509-3-5P|MIMAT0004975 | 3.3e-10 | 5 | 4e-08 | 4 |
| HSA-MIR-509-3P|MIMAT0002881 | 7.7e-12 | 5 | 4.6e-09 | 4 |
| HSA-MIR-506-3P|MIMAT0002878 | 3.3e-09 | 4.4 | 2.8e-07 | 4 |
| HSA-MIR-513C-5P|MIMAT0005789 | 1.7e-08 | 4.3 | 1.1e-06 | 4 |
| HSA-MIR-513A-5P|MIMAT0002877 | 1.3e-08 | 4.1 | 9.8e-07 | 4 |
| HSA-MIR-513B-5P|MIMAT0005788 | 0.00018 | 2.7 | 0.0024 | 4 |
| HSA-MIR-509-5P|MIMAT0004779 | 0.00045 | 2.7 | 0.0046 | 4 |
| HSA-MIR-514B-5P|MIMAT0015087 | 0.00074 | 2.5 | 0.0063 | 4 |
| HSA-MIR-507|MIMAT0002879 | 0.0016 | 2.4 | 0.012 | 4 |
| HSA-MIR-19A-3P|MIMAT0000073 | 1.2e-06 | 2.1 | 0.000046 | 4 |
| HSA-MIR-335-5P|MIMAT0000765 | 0.00051 | 1.9 | 0.0049 | 4 |
| HSA-MIR-374A-5P|MIMAT0000727 | 3.5e-06 | 1.9 | 0.00011 | 4 |
| HSA-MIR-219A-5P|MIMAT0000276 | 0.0013 | 1.8 | 0.01 | 4 |
| HSA-MIR-101-3P|MIMAT0000099 | 6.1e-06 | 1.8 | 0.00016 | 4 |
| HSA-MIR-1270|MIMAT0005924 | 0.000017 | 1.8 | 0.00036 | 4 |
| HSA-MIR-514B-3P|MIMAT0015088 | 0.011 | 1.8 | 0.048 | 4 |
| HSA-MIR-651-5P|MIMAT0003321 | 2.2e-06 | 1.7 | 0.000077 | 4 |
| HSA-MIR-101-5P|MIMAT0004513 | 5.4e-06 | 1.7 | 0.00015 | 4 |
| HSA-MIR-335-3P|MIMAT0004703 | 0.00068 | 1.6 | 0.006 | 4 |
| HSA-MIR-99A-5P|MIMAT0000097 | 1.8e-08 | 1.5 | 1.1e-06 | 4 |
| HSA-MIR-20A-5P|MIMAT0000075 | 1.3e-07 | 1.5 | 6.8e-06 | 4 |
| HSA-MIR-19B-3P|MIMAT0000074 | 1.9e-06 | 1.5 | 0.000072 | 4 |
| HSA-MIR-374A-3P|MIMAT0004688 | 0.000016 | 1.4 | 0.00036 | 4 |
| HSA-MIR-30E-5P|MIMAT0000692 | 4e-05 | 1.3 | 0.00073 | 4 |
| HSA-MIR-30A-5P|MIMAT0000087 | 0.000081 | 1.3 | 0.0013 | 4 |
| HSA-MIR-548V|MIMAT0015020 | 0.0049 | 1.3 | 0.026 | 4 |
| HSA-MIR-582-3P|MIMAT0004797 | 0.017 | 1.2 | 0.07 | 4 |
| HSA-MIR-140-5P|MIMAT0000431 | 0.00028 | 1.2 | 0.0032 | 4 |
| HSA-MIR-130A-3P|MIMAT0000425 | 8.3e-10 | 1.2 | 8.2e-08 | 4 |
| HSA-MIR-20A-3P|MIMAT0004493 | 4.3e-06 | 1.2 | 0.00013 | 4 |
| HSA-MIR-99A-3P|MIMAT0004511 | 0.000036 | 1.2 | 0.00068 | 4 |
| HSA-MIR-29C-3P|MIMAT0000681 | 0.000017 | 1.1 | 0.00036 | 4 |
| HSA-MIR-100-5P|MIMAT0000098 | 0.0072 | 1.1 | 0.035 | 4 |
| HSA-MIR-935|MIMAT0004978 | 0.048 | 1.1 | 0.15 | 4 |
| HSA-MIR-181C-5P|MIMAT0000258 | 0.0019 | 1.1 | 0.013 | 4 |
| HSA-MIR-125B-2-3P|MIMAT0004603 | 0.00014 | 1.1 | 0.002 | 4 |
| HSA-MIR-194-5P|MIMAT0000460 | 0.0017 | 1.1 | 0.012 | 4 |
| HSA-MIR-106A-5P|MIMAT0000103 | 0.00026 | 1.1 | 0.0031 | 4 |
| HSA-MIR-32-5P|MIMAT0000090 | 0.016 | 1 | 0.066 | 4 |
| HSA-MIR-2116-3P|MIMAT0011161 | 0.0019 | 1 | 0.013 | 4 |
| HSA-LET-7C-5P|MIMAT0000064 | 0.00021 | 1 | 0.0026 | 4 |
| HSA-MIR-624-5P|MIMAT0003293 | 0.00025 | 1 | 0.003 | 4 |
| HSA-MIR-301A-3P|MIMAT0000688 | 0.02 | 0.98 | 0.077 | 4 |
| HSA-MIR-590-5P|MIMAT0003258 | 0.00053 | 0.96 | 0.0049 | 4 |
| HSA-MIR-20B-5P|MIMAT0001413 | 0.014 | 0.95 | 0.059 | 4 |
| HSA-MIR-125B-5P|MIMAT0000423 | 0.011 | 0.93 | 0.047 | 4 |
| HSA-MIR-18A-5P|MIMAT0000072 | 0.0037 | 0.92 | 0.021 | 4 |
| HSA-MIR-455-5P|MIMAT0003150 | 0.0041 | 0.92 | 0.023 | 4 |
| HSA-MIR-374B-3P|MIMAT0004956 | 0.00026 | 0.91 | 0.0031 | 4 |
| HSA-MIR-140-3P|MIMAT0004597 | 0.0019 | 0.89 | 0.013 | 4 |
| HSA-MIR-106B-5P|MIMAT0000680 | 0.000035 | 0.89 | 0.00068 | 4 |
| HSA-MIR-222-3P|MIMAT0000279 | 0.014 | 0.88 | 0.057 | 4 |
| HSA-MIR-1271-5P|MIMAT0005796 | 0.007 | 0.87 | 0.034 | 4 |
| HSA-MIR-590-3P|MIMAT0004801 | 0.0025 | 0.87 | 0.016 | 4 |
| HSA-MIR-222-5P|MIMAT0004569 | 0.0027 | 0.86 | 0.017 | 4 |
| HSA-MIR-33A-5P|MIMAT0000091 | 0.034 | 0.84 | 0.12 | 4 |
| HSA-MIR-181A-5P|MIMAT0000256 | 0.0058 | 0.83 | 0.029 | 4 |
| HSA-MIR-491-3P|MIMAT0004765 | 0.0058 | 0.79 | 0.029 | 4 |
| HSA-LET-7G-3P|MIMAT0004584 | 0.012 | 0.78 | 0.051 | 4 |
| HSA-MIR-28-5P|MIMAT0000085 | 0.00017 | 0.77 | 0.0023 | 4 |
| HSA-MIR-219A-1-3P|MIMAT0004567 | 0.0025 | 0.77 | 0.016 | 4 |
| HSA-MIR-181B-5P|MIMAT0000257 | 0.0012 | 0.77 | 0.01 | 4 |
| HSA-MIR-3154|MIMAT0015028 | 0.035 | 0.75 | 0.12 | 4 |
| HSA-MIR-126-5P|MIMAT0000444 | 0.016 | 0.75 | 0.066 | 4 |
| HSA-MIR-374B-5P|MIMAT0004955 | 0.0078 | 0.75 | 0.037 | 4 |
| HSA-MIR-192-3P|MIMAT0004543 | 0.023 | 0.74 | 0.085 | 4 |
| HSA-MIR-340-5P|MIMAT0004692 | 0.008 | 0.74 | 0.038 | 4 |
| HSA-MIR-1249-3P|MIMAT0005901 | 0.012 | 0.72 | 0.051 | 4 |
| HSA-MIR-17-5P|MIMAT0000070 | 8.2e-06 | 0.72 | 0.0002 | 4 |
| HSA-MIR-181A-2-3P|MIMAT0004558 | 0.015 | 0.69 | 0.062 | 4 |
| HSA-MIR-1296-5P|MIMAT0005794 | 0.0057 | 0.68 | 0.029 | 4 |
| HSA-MIR-363-3P|MIMAT0000707 | 0.044 | 0.66 | 0.14 | 4 |
| HSA-MIR-3913-5P|MIMAT0018187 | 0.033 | 0.61 | 0.11 | 4 |
| HSA-MIR-192-5P|MIMAT0000222 | 0.025 | 0.58 | 0.091 | 4 |
| HSA-MIR-17-3P|MIMAT0000071 | 0.0031 | 0.58 | 0.019 | 4 |
| HSA-MIR-181D-5P|MIMAT0002821 | 0.043 | 0.53 | 0.14 | 4 |
| HSA-MIR-30B-5P|MIMAT0000420 | 0.0044 | 0.51 | 0.025 | 4 |
| HSA-MIR-19B-1-5P|MIMAT0004491 | 0.0013 | 0.48 | 0.01 | 4 |
| HSA-MIR-30C-5P|MIMAT0000244 | 0.029 | 0.45 | 0.1 | 4 |
| HSA-LET-7G-5P|MIMAT0000414 | 0.022 | 0.36 | 0.084 | 4 |
| HSA-MIR-92A-3P|MIMAT0000092 | 0.037 | 0.36 | 0.12 | 4 |
| HSA-MIR-340-3P|MIMAT0000750 | 0.043 | -0.28 | 0.14 | 4 |
| HSA-MIR-98-5P|MIMAT0000096 | 0.035 | -0.29 | 0.12 | 4 |
| HSA-MIR-664A-5P|MIMAT0005948 | 0.036 | -0.33 | 0.12 | 4 |
| HSA-MIR-27B-3P|MIMAT0000419 | 0.0047 | -0.34 | 0.026 | 4 |
| HSA-MIR-128-3P|MIMAT0000424 | 0.0089 | -0.37 | 0.041 | 4 |
| HSA-MIR-671-5P|MIMAT0003880 | 0.03 | -0.4 | 0.1 | 4 |
| HSA-MIR-532-3P|MIMAT0004780 | 0.025 | -0.41 | 0.092 | 4 |
| HSA-MIR-24-1-5P|MIMAT0000079 | 0.0062 | -0.44 | 0.031 | 4 |
| HSA-MIR-342-5P|MIMAT0004694 | 0.045 | -0.44 | 0.14 | 4 |
| HSA-MIR-148B-3P|MIMAT0000759 | 0.00053 | -0.44 | 0.0049 | 4 |
| HSA-LET-7A-3P|MIMAT0004481 | 0.015 | -0.45 | 0.06 | 4 |
| HSA-MIR-24-3P|MIMAT0000080 | 0.003 | -0.45 | 0.018 | 4 |
| HSA-MIR-103A-3P|MIMAT0000101 | 0.0047 | -0.46 | 0.026 | 4 |
| HSA-LET-7E-5P|MIMAT0000066 | 0.045 | -0.46 | 0.14 | 4 |
| HSA-MIR-126-3P|MIMAT0000445 | 0.0074 | -0.48 | 0.035 | 4 |
| HSA-MIR-505-5P|MIMAT0004776 | 0.048 | -0.5 | 0.15 | 4 |
| HSA-MIR-505-3P|MIMAT0002876 | 0.031 | -0.5 | 0.11 | 4 |
| HSA-MIR-342-3P|MIMAT0000753 | 0.0095 | -0.51 | 0.043 | 4 |
| HSA-MIR-502-3P|MIMAT0004775 | 0.00053 | -0.51 | 0.0049 | 4 |
| HSA-MIR-628-5P|MIMAT0004809 | 0.033 | -0.51 | 0.11 | 4 |
| HSA-MIR-877-5P|MIMAT0004949 | 0.034 | -0.53 | 0.12 | 4 |
| HSA-MIR-218-5P|MIMAT0000275 | 0.045 | -0.55 | 0.14 | 4 |
| HSA-MIR-361-3P|MIMAT0004682 | 0.00033 | -0.56 | 0.0036 | 4 |
| HSA-MIR-27B-5P|MIMAT0004588 | 0.0019 | -0.56 | 0.013 | 4 |
| HSA-MIR-598-3P|MIMAT0003266 | 0.0058 | -0.57 | 0.029 | 4 |
| HSA-MIR-125A-3P|MIMAT0004602 | 0.0047 | -0.57 | 0.026 | 4 |
| HSA-MIR-7-5P|MIMAT0000252 | 0.044 | -0.59 | 0.14 | 4 |
| HSA-MIR-550A-3P|MIMAT0003257 | 0.047 | -0.6 | 0.14 | 4 |
| HSA-MIR-200C-3P|MIMAT0000617 | 0.012 | -0.61 | 0.053 | 4 |
| HSA-MIR-24-2-5P|MIMAT0004497 | 0.0018 | -0.63 | 0.012 | 4 |
| HSA-MIR-3682-3P|MIMAT0018110 | 0.035 | -0.64 | 0.12 | 4 |
| HSA-MIR-345-5P|MIMAT0000772 | 0.019 | -0.65 | 0.075 | 4 |
| HSA-MIR-628-3P|MIMAT0003297 | 0.021 | -0.66 | 0.081 | 4 |
| HSA-MIR-141-5P|MIMAT0004598 | 0.013 | -0.67 | 0.054 | 4 |
| HSA-MIR-652-3P|MIMAT0003322 | 0.00053 | -0.67 | 0.0049 | 4 |
| HSA-MIR-193A-5P|MIMAT0004614 | 0.000011 | -0.69 | 0.00026 | 4 |
| HSA-MIR-324-5P|MIMAT0000761 | 0.0026 | -0.7 | 0.017 | 4 |
| HSA-MIR-200A-3P|MIMAT0000682 | 0.04 | -0.71 | 0.13 | 4 |
| HSA-MIR-421|MIMAT0003339 | 0.0095 | -0.71 | 0.043 | 4 |
| HSA-MIR-1307-3P|MIMAT0005951 | 0.000033 | -0.73 | 0.00065 | 4 |
| HSA-MIR-627-5P|MIMAT0003296 | 0.0048 | -0.74 | 0.026 | 4 |
| HSA-MIR-22-3P|MIMAT0000077 | 0.0016 | -0.74 | 0.012 | 4 |
| HSA-MIR-29B-1-5P|MIMAT0004514 | 0.0048 | -0.75 | 0.026 | 4 |
| HSA-MIR-200B-3P|MIMAT0000318 | 0.00057 | -0.76 | 0.0051 | 4 |
| HSA-MIR-99B-5P|MIMAT0000689 | 0.0032 | -0.76 | 0.019 | 4 |
| HSA-MIR-760|MIMAT0004957 | 0.02 | -0.8 | 0.077 | 4 |
| HSA-MIR-940|MIMAT0004983 | 0.0017 | -0.8 | 0.012 | 4 |
| HSA-MIR-502-5P|MIMAT0002873 | 0.012 | -0.81 | 0.051 | 4 |
| HSA-MIR-484|MIMAT0002174 | 0.0054 | -0.82 | 0.028 | 4 |
| HSA-MIR-369-3P|MIMAT0000721 | 0.03 | -0.83 | 0.1 | 4 |
| HSA-MIR-543|MIMAT0004954 | 0.02 | -0.83 | 0.077 | 4 |
| HSA-MIR-500A-3P|MIMAT0002871 | 0.00028 | -0.84 | 0.0032 | 4 |
| HSA-MIR-132-5P|MIMAT0004594 | 0.00037 | -0.84 | 0.0039 | 4 |
| HSA-MIR-1248|MIMAT0005900 | 0.011 | -0.85 | 0.047 | 4 |
| HSA-MIR-483-5P|MIMAT0004761 | 0.043 | -0.86 | 0.14 | 4 |
| HSA-MIR-1301-3P|MIMAT0005797 | 0.00019 | -0.86 | 0.0024 | 4 |
| HSA-MIR-1976|MIMAT0009451 | 0.00039 | -0.86 | 0.004 | 4 |
| HSA-MIR-31-5P|MIMAT0000089 | 0.008 | -0.88 | 0.038 | 4 |
| HSA-MIR-188-5P|MIMAT0000457 | 0.0018 | -0.91 | 0.012 | 4 |
| HSA-MIR-493-5P|MIMAT0002813 | 0.029 | -0.93 | 0.1 | 4 |
| HSA-MIR-143-5P|MIMAT0004599 | 0.012 | -0.93 | 0.051 | 4 |
| HSA-MIR-4286|MIMAT0016916 | 0.011 | -0.93 | 0.047 | 4 |
| HSA-MIR-3065-5P|MIMAT0015066 | 0.018 | -0.94 | 0.072 | 4 |
| HSA-MIR-143-3P|MIMAT0000435 | 0.0014 | -0.94 | 0.011 | 4 |
| HSA-MIR-150-3P|MIMAT0004610 | 0.04 | -0.94 | 0.13 | 4 |
| HSA-MIR-149-5P|MIMAT0000450 | 0.00037 | -0.96 | 0.0039 | 4 |
| HSA-MIR-3189-3P|MIMAT0015071 | 0.018 | -0.96 | 0.072 | 4 |
| HSA-MIR-675-3P|MIMAT0006790 | 0.041 | -0.96 | 0.13 | 4 |
| HSA-MIR-504-5P|MIMAT0002875 | 0.038 | -0.98 | 0.13 | 4 |
| HSA-MIR-765|MIMAT0003945 | 0.026 | -0.99 | 0.094 | 4 |
| HSA-MIR-581|MIMAT0003246 | 0.0066 | -1 | 0.033 | 4 |
| HSA-MIR-135A-5P|MIMAT0000428 | 0.031 | -1 | 0.11 | 4 |
| HSA-MIR-200B-5P|MIMAT0004571 | 0.023 | -1 | 0.085 | 4 |
| HSA-MIR-3690|MIMAT0018119 | 0.025 | -1 | 0.092 | 4 |
| HSA-MIR-501-5P|MIMAT0002872 | 3.4e-06 | -1 | 0.00011 | 4 |
| HSA-MIR-145-3P|MIMAT0004601 | 0.0002 | -1.1 | 0.0026 | 4 |
| HSA-MIR-330-5P|MIMAT0004693 | 0.000042 | -1.1 | 0.00074 | 4 |
| HSA-MIR-212-3P|MIMAT0000269 | 0.000059 | -1.1 | 0.001 | 4 |
| HSA-MIR-511-5P|MIMAT0002808 | 0.0068 | -1.1 | 0.033 | 4 |
| HSA-MIR-139-3P|MIMAT0004552 | 0.002 | -1.1 | 0.013 | 4 |
| HSA-MIR-129-5P|MIMAT0000242 | 0.00092 | -1.1 | 0.0078 | 4 |
| HSA-MIR-1237-3P|MIMAT0005592 | 0.018 | -1.1 | 0.072 | 4 |
| HSA-MIR-766-3P|MIMAT0003888 | 0.0003 | -1.1 | 0.0033 | 4 |
| HSA-MIR-154-5P|MIMAT0000452 | 0.0083 | -1.1 | 0.038 | 4 |
| HSA-MIR-99B-3P|MIMAT0004678 | 0.000081 | -1.1 | 0.0013 | 4 |
| HSA-MIR-146B-3P|MIMAT0004766 | 0.0019 | -1.1 | 0.013 | 4 |
| HSA-MIR-937-3P|MIMAT0004980 | 0.00071 | -1.1 | 0.0062 | 4 |
| HSA-MIR-483-3P|MIMAT0002173 | 0.00014 | -1.2 | 0.002 | 4 |
| HSA-MIR-501-3P|MIMAT0004774 | 3.9e-07 | -1.2 | 2e-05 | 4 |
| HSA-MIR-214-5P|MIMAT0004564 | 0.0028 | -1.2 | 0.017 | 4 |
| HSA-MIR-146B-5P|MIMAT0002809 | 0.0011 | -1.2 | 0.0086 | 4 |
| HSA-MIR-431-3P|MIMAT0004757 | 0.005 | -1.2 | 0.026 | 4 |
| HSA-MIR-1275|MIMAT0005929 | 0.038 | -1.2 | 0.13 | 4 |
| HSA-MIR-452-5P|MIMAT0001635 | 0.000096 | -1.3 | 0.0015 | 4 |
| HSA-MIR-199B-3P|MIMAT0004563 | 0.0036 | -1.3 | 0.021 | 4 |
| HSA-MIR-199A-3P|MIMAT0000232 | 0.0035 | -1.3 | 0.021 | 4 |
| HSA-MIR-145-5P|MIMAT0000437 | 0.000011 | -1.3 | 0.00026 | 4 |
| HSA-MIR-9-5P|MIMAT0000441 | 0.026 | -1.3 | 0.093 | 4 |
| HSA-MIR-224-5P|MIMAT0000281 | 0.00017 | -1.4 | 0.0023 | 4 |
| HSA-MIR-22-5P|MIMAT0004495 | 7.5e-06 | -1.4 | 0.00019 | 4 |
| HSA-MIR-105-5P|MIMAT0000102 | 0.045 | -1.4 | 0.14 | 4 |
| HSA-MIR-369-5P|MIMAT0001621 | 0.015 | -1.5 | 0.062 | 4 |
| HSA-MIR-362-5P|MIMAT0000705 | 9.5e-07 | -1.5 | 0.000041 | 4 |
| HSA-MIR-199A-5P|MIMAT0000231 | 0.0016 | -1.6 | 0.012 | 4 |
| HSA-MIR-346|MIMAT0000773 | 0.005 | -1.6 | 0.026 | 4 |
| HSA-MIR-155-5P|MIMAT0000646 | 0.00015 | -1.7 | 0.0022 | 4 |
| HSA-MIR-200A-5P|MIMAT0001620 | 5.1e-07 | -1.7 | 0.000023 | 4 |
| HSA-MIR-592|MIMAT0003260 | 0.001 | -1.7 | 0.0083 | 4 |
| HSA-MIR-150-5P|MIMAT0000451 | 0.00072 | -1.8 | 0.0062 | 4 |
| HSA-MIR-708-3P|MIMAT0004927 | 0.0018 | -1.8 | 0.012 | 4 |
| HSA-MIR-708-5P|MIMAT0004926 | 0.000077 | -1.9 | 0.0013 | 4 |
| HSA-MIR-129-2-3P|MIMAT0004605 | 0.0029 | -2 | 0.018 | 4 |
| HSA-MIR-887-3P|MIMAT0004951 | 0.00047 | -2 | 0.0047 | 4 |
| HSA-MIR-767-5P|MIMAT0003882 | 0.0043 | -2.1 | 0.025 | 4 |
| HSA-MIR-508-5P|MIMAT0004778 | 7.7e-06 | 4.8 | 0.0014 | 5 |
| HSA-MIR-513C-5P|MIMAT0005789 | 2e-05 | 4.6 | 0.0017 | 5 |
| HSA-MIR-508-3P|MIMAT0002880 | 0.000018 | 4.6 | 0.0017 | 5 |
| HSA-MIR-509-3P|MIMAT0002881 | 9.5e-06 | 4.5 | 0.0014 | 5 |
| HSA-MIR-506-3P|MIMAT0002878 | 0.000033 | 4.4 | 0.0024 | 5 |
| HSA-MIR-514A-3P|MIMAT0002883 | 0.00041 | 3.7 | 0.017 | 5 |
| HSA-MIR-509-3-5P|MIMAT0004975 | 0.0031 | 3.5 | 0.045 | 5 |
| HSA-MIR-196B-5P|MIMAT0001080 | 0.012 | 3.2 | 0.088 | 5 |
| HSA-MIR-513A-5P|MIMAT0002877 | 0.0045 | 3 | 0.055 | 5 |
| HSA-MIR-514B-5P|MIMAT0015087 | 0.0027 | 2.7 | 0.045 | 5 |
| HSA-MIR-513B-5P|MIMAT0005788 | 0.028 | 2.2 | 0.15 | 5 |
| HSA-MIR-548V|MIMAT0015020 | 0.0031 | 1.8 | 0.045 | 5 |
| HSA-MIR-514B-3P|MIMAT0015088 | 0.047 | 1.6 | 0.2 | 5 |
| HSA-MIR-1270|MIMAT0005924 | 0.012 | 1.6 | 0.088 | 5 |
| HSA-MIR-221-3P|MIMAT0000278 | 0.000056 | 1.6 | 0.0036 | 5 |
| HSA-MIR-1296-5P|MIMAT0005794 | 2e-05 | 1.2 | 0.0017 | 5 |
| HSA-MIR-4326|MIMAT0016888 | 0.0043 | 1.2 | 0.054 | 5 |
| HSA-MIR-197-3P|MIMAT0000227 | 0.0013 | 1.2 | 0.036 | 5 |
| HSA-MIR-221-5P|MIMAT0004568 | 0.0012 | 1.2 | 0.036 | 5 |
| HSA-MIR-1468-5P|MIMAT0006789 | 0.0049 | 1.2 | 0.057 | 5 |
| HSA-MIR-181A-2-3P|MIMAT0004558 | 0.00016 | 1.1 | 0.0072 | 5 |
| HSA-MIR-1248|MIMAT0005900 | 0.012 | 1.1 | 0.088 | 5 |
| HSA-MIR-138-1-3P|MIMAT0004607 | 1.6e-06 | 1.1 | 0.00094 | 5 |
| HSA-MIR-369-5P|MIMAT0001621 | 0.011 | 1.1 | 0.087 | 5 |
| HSA-MIR-1910-5P|MIMAT0007884 | 0.024 | 1 | 0.14 | 5 |
| HSA-MIR-141-5P|MIMAT0004598 | 0.029 | 1 | 0.15 | 5 |
| HSA-MIR-1226-3P|MIMAT0005577 | 0.003 | 1 | 0.045 | 5 |
| HSA-MIR-222-3P|MIMAT0000279 | 0.0052 | 1 | 0.058 | 5 |
| HSA-MIR-769-3P|MIMAT0003887 | 8.4e-06 | 0.97 | 0.0014 | 5 |
| HSA-MIR-935|MIMAT0004978 | 0.028 | 0.93 | 0.15 | 5 |
| HSA-MIR-211-5P|MIMAT0000268 | 0.014 | 0.93 | 0.095 | 5 |
| HSA-MIR-362-5P|MIMAT0000705 | 0.032 | 0.93 | 0.16 | 5 |
| HSA-MIR-28-3P|MIMAT0004502 | 0.00013 | 0.93 | 0.0066 | 5 |
| HSA-MIR-320B|MIMAT0005792 | 0.0083 | 0.9 | 0.075 | 5 |
| HSA-MIR-876-5P|MIMAT0004924 | 0.008 | 0.9 | 0.073 | 5 |
| HSA-MIR-548S|MIMAT0014987 | 0.014 | 0.89 | 0.096 | 5 |
| HSA-MIR-130A-5P|MIMAT0004593 | 0.003 | 0.89 | 0.045 | 5 |
| HSA-MIR-320C|MIMAT0005793 | 0.0092 | 0.88 | 0.079 | 5 |
| HSA-MIR-328-3P|MIMAT0000752 | 0.045 | 0.87 | 0.2 | 5 |
| HSA-LET-7C-5P|MIMAT0000064 | 0.0033 | 0.87 | 0.046 | 5 |
| HSA-MIR-186-3P|MIMAT0004612 | 0.02 | 0.86 | 0.12 | 5 |
| HSA-MIR-219A-1-3P|MIMAT0004567 | 0.0022 | 0.86 | 0.045 | 5 |
| HSA-MIR-222-5P|MIMAT0004569 | 0.0086 | 0.85 | 0.077 | 5 |
| HSA-MIR-320A|MIMAT0000510 | 0.0052 | 0.83 | 0.058 | 5 |
| HSA-MIR-181A-5P|MIMAT0000256 | 0.0025 | 0.83 | 0.045 | 5 |
| HSA-MIR-455-3P|MIMAT0004784 | 0.014 | 0.82 | 0.097 | 5 |
| HSA-MIR-99A-3P|MIMAT0004511 | 0.003 | 0.82 | 0.045 | 5 |
| HSA-MIR-26B-3P|MIMAT0004500 | 0.011 | 0.8 | 0.084 | 5 |
| HSA-MIR-181B-5P|MIMAT0000257 | 0.01 | 0.8 | 0.084 | 5 |
| HSA-MIR-1249-3P|MIMAT0005901 | 0.0015 | 0.77 | 0.04 | 5 |
| HSA-MIR-191-3P|MIMAT0001618 | 0.018 | 0.77 | 0.11 | 5 |
| HSA-MIR-532-3P|MIMAT0004780 | 0.0025 | 0.75 | 0.045 | 5 |
| HSA-MIR-191-5P|MIMAT0000440 | 0.00012 | 0.73 | 0.0066 | 5 |
| HSA-MIR-616-3P|MIMAT0004805 | 0.0071 | 0.72 | 0.068 | 5 |
| HSA-MIR-1262|MIMAT0005914 | 0.028 | 0.71 | 0.15 | 5 |
| HSA-MIR-500A-3P|MIMAT0002871 | 0.0042 | 0.7 | 0.054 | 5 |
| HSA-MIR-378A-5P|MIMAT0000731 | 0.049 | 0.7 | 0.21 | 5 |
| HSA-MIR-2116-3P|MIMAT0011161 | 0.03 | 0.69 | 0.15 | 5 |
| HSA-MIR-23B-5P|MIMAT0004587 | 0.0018 | 0.65 | 0.042 | 5 |
| HSA-MIR-3917|MIMAT0018191 | 0.033 | 0.65 | 0.17 | 5 |
| HSA-MIR-93-3P|MIMAT0004509 | 0.00016 | 0.65 | 0.0072 | 5 |
| HSA-MIR-140-3P|MIMAT0004597 | 0.015 | 0.63 | 0.099 | 5 |
| HSA-MIR-576-5P|MIMAT0003241 | 0.032 | 0.59 | 0.16 | 5 |
| HSA-MIR-7-1-3P|MIMAT0004553 | 0.0044 | 0.59 | 0.054 | 5 |
| HSA-MIR-28-5P|MIMAT0000085 | 0.0036 | 0.55 | 0.049 | 5 |
| HSA-MIR-25-3P|MIMAT0000081 | 0.02 | 0.53 | 0.12 | 5 |
| HSA-MIR-186-5P|MIMAT0000456 | 0.011 | 0.51 | 0.087 | 5 |
| HSA-MIR-3136-5P|MIMAT0015003 | 0.034 | 0.51 | 0.17 | 5 |
| HSA-MIR-505-3P|MIMAT0002876 | 0.0033 | 0.51 | 0.046 | 5 |
| HSA-MIR-3928-3P|MIMAT0018205 | 0.05 | 0.49 | 0.21 | 5 |
| HSA-MIR-3615|MIMAT0017994 | 0.046 | 0.49 | 0.2 | 5 |
| HSA-LET-7D-3P|MIMAT0004484 | 0.045 | 0.48 | 0.2 | 5 |
| HSA-MIR-769-5P|MIMAT0003886 | 0.02 | 0.46 | 0.12 | 5 |
| HSA-LET-7G-5P|MIMAT0000414 | 0.024 | 0.42 | 0.14 | 5 |
| HSA-MIR-148B-3P|MIMAT0000759 | 0.04 | -0.27 | 0.19 | 5 |
| HSA-MIR-7-5P|MIMAT0000252 | 0.043 | -0.42 | 0.2 | 5 |
| HSA-MIR-24-2-5P|MIMAT0004497 | 0.0057 | -0.42 | 0.061 | 5 |
| HSA-MIR-30D-5P|MIMAT0000245 | 0.044 | -0.49 | 0.2 | 5 |
| HSA-MIR-24-3P|MIMAT0000080 | 0.0022 | -0.49 | 0.045 | 5 |
| HSA-MIR-21-3P|MIMAT0004494 | 0.042 | -0.54 | 0.2 | 5 |
| HSA-LET-7E-5P|MIMAT0000066 | 0.03 | -0.58 | 0.15 | 5 |
| HSA-MIR-200C-3P|MIMAT0000617 | 0.043 | -0.59 | 0.2 | 5 |
| HSA-MIR-92B-3P|MIMAT0003218 | 0.028 | -0.6 | 0.15 | 5 |
| HSA-MIR-16-5P|MIMAT0000069 | 0.002 | -0.61 | 0.044 | 5 |
| HSA-LET-7A-3P|MIMAT0004481 | 0.01 | -0.62 | 0.084 | 5 |
| HSA-MIR-27A-3P|MIMAT0000084 | 0.00058 | -0.63 | 0.021 | 5 |
| HSA-MIR-193A-3P|MIMAT0000459 | 0.017 | -0.65 | 0.11 | 5 |
| HSA-MIR-29A-5P|MIMAT0004503 | 0.00098 | -0.66 | 0.031 | 5 |
| HSA-LET-7F-1-3P|MIMAT0004486 | 0.039 | -0.69 | 0.19 | 5 |
| HSA-MIR-3940-3P|MIMAT0018356 | 0.01 | -0.73 | 0.084 | 5 |
| HSA-MIR-16-1-3P|MIMAT0004489 | 0.021 | -0.78 | 0.12 | 5 |
| HSA-MIR-193B-3P|MIMAT0002819 | 0.026 | -0.82 | 0.15 | 5 |
| HSA-MIR-34A-5P|MIMAT0000255 | 0.0092 | -0.82 | 0.079 | 5 |
| HSA-MIR-937-3P|MIMAT0004980 | 0.015 | -0.84 | 0.1 | 5 |
| HSA-MIR-365A-3P|MIMAT0000710 | 0.027 | -0.84 | 0.15 | 5 |
| HSA-MIR-30E-5P|MIMAT0000692 | 0.031 | -0.89 | 0.16 | 5 |
| HSA-MIR-17-5P|MIMAT0000070 | 0.0071 | -0.93 | 0.068 | 5 |
| HSA-MIR-346|MIMAT0000773 | 0.0066 | -0.94 | 0.066 | 5 |
| HSA-LET-7B-3P|MIMAT0004482 | 0.0065 | -0.96 | 0.066 | 5 |
| HSA-MIR-497-5P|MIMAT0002820 | 0.0024 | -0.97 | 0.045 | 5 |
| HSA-MIR-181C-5P|MIMAT0000258 | 0.015 | -0.99 | 0.1 | 5 |
| HSA-MIR-224-5P|MIMAT0000281 | 0.043 | -1 | 0.2 | 5 |
| HSA-MIR-212-3P|MIMAT0000269 | 0.018 | -1 | 0.11 | 5 |
| HSA-MIR-195-5P|MIMAT0000461 | 0.0056 | -1 | 0.061 | 5 |
| HSA-MIR-362-3P|MIMAT0004683 | 0.021 | -1 | 0.12 | 5 |
| HSA-MIR-106B-5P|MIMAT0000680 | 0.0028 | -1 | 0.045 | 5 |
| HSA-MIR-33A-3P|MIMAT0004506 | 0.00081 | -1.1 | 0.028 | 5 |
| HSA-MIR-3166|MIMAT0015040 | 0.0066 | -1.1 | 0.066 | 5 |
| HSA-MIR-200B-3P|MIMAT0000318 | 0.0046 | -1.1 | 0.055 | 5 |
| HSA-MIR-374A-3P|MIMAT0004688 | 0.047 | -1.1 | 0.2 | 5 |
| HSA-MIR-452-5P|MIMAT0001635 | 0.023 | -1.1 | 0.14 | 5 |
| HSA-MIR-19B-3P|MIMAT0000074 | 0.035 | -1.2 | 0.17 | 5 |
| HSA-MIR-708-3P|MIMAT0004927 | 0.04 | -1.2 | 0.19 | 5 |
| HSA-MIR-132-3P|MIMAT0000426 | 0.0017 | -1.2 | 0.042 | 5 |
| HSA-MIR-199B-3P|MIMAT0004563 | 0.01 | -1.2 | 0.084 | 5 |
| HSA-MIR-199A-3P|MIMAT0000232 | 0.01 | -1.2 | 0.084 | 5 |
| HSA-MIR-199A-5P|MIMAT0000231 | 0.045 | -1.2 | 0.2 | 5 |
| HSA-MIR-29B-3P|MIMAT0000100 | 0.0013 | -1.2 | 0.036 | 5 |
| HSA-MIR-374B-5P|MIMAT0004955 | 0.025 | -1.2 | 0.14 | 5 |
| HSA-MIR-142-5P|MIMAT0000433 | 0.029 | -1.3 | 0.15 | 5 |
| HSA-MIR-887-3P|MIMAT0004951 | 0.0076 | -1.4 | 0.071 | 5 |
| HSA-MIR-340-5P|MIMAT0004692 | 0.013 | -1.4 | 0.093 | 5 |
| HSA-MIR-21-5P|MIMAT0000076 | 0.012 | -1.4 | 0.088 | 5 |
| HSA-MIR-142-3P|MIMAT0000434 | 0.013 | -1.4 | 0.094 | 5 |
| HSA-MIR-15A-5P|MIMAT0000068 | 0.00053 | -1.4 | 0.02 | 5 |
| HSA-MIR-33A-5P|MIMAT0000091 | 0.029 | -1.4 | 0.15 | 5 |
| HSA-MIR-18A-5P|MIMAT0000072 | 0.0018 | -1.5 | 0.042 | 5 |
| HSA-MIR-101-3P|MIMAT0000099 | 0.0065 | -1.6 | 0.066 | 5 |
| HSA-MIR-126-5P|MIMAT0000444 | 0.0026 | -1.6 | 0.045 | 5 |
| HSA-MIR-301A-3P|MIMAT0000688 | 0.04 | -1.6 | 0.19 | 5 |
| HSA-MIR-592|MIMAT0003260 | 0.0027 | -1.7 | 0.045 | 5 |
| HSA-MIR-653-5P|MIMAT0003328 | 0.007 | -1.7 | 0.068 | 5 |
| HSA-MIR-20A-5P|MIMAT0000075 | 0.0039 | -1.7 | 0.051 | 5 |
| HSA-MIR-144-5P|MIMAT0004600 | 0.012 | -1.8 | 0.088 | 5 |
| HSA-MIR-374A-5P|MIMAT0000727 | 0.014 | -1.8 | 0.095 | 5 |
| HSA-MIR-19A-3P|MIMAT0000073 | 0.016 | -1.8 | 0.1 | 5 |
Methods & Data
Input
miR (MIMATs) of RPM value (reads per million reads aligned to miRBase mature) with log2 transformed was as the input data for the clustering.
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Input file = TCGA-UVM-TP.expclu.gct
Consensus Hierarchical Clustering
Consensus Hierarchical clustering is a resampling-based clustering. It provides for a method to represent the consensus across multiple runs of a clustering algorithm and to assess the stability of the discovered clusters. To this end, perturbations of the original data are simulated by resampling techniques [1],[2].
Silhouette Width
Silhouette width is defined as the ratio of average distance of each sample to samples in the same cluster to the smallest distance to samples not in the same cluster. If silhouette width is close to 1, it means that sample is well clustered. If silhouette width is close to -1, it means that sample is misclassified[3][5].
Cophenetic Correlation Coefficient and How to select the best cluster
The cophenetic correlation coefficient is computed as the Pearson correlation of two distance matrices:
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Distance between samples induced by the consensus matrix.
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Distance between samples induced by the linkage used in reordering the consensus matrix.
The cophenetic correlation coefficients and average silhouette values are used to determine the k with the most robust clusterings. From the plot of cophenetic correlation versus k, we select modes and the the point preceding the greatest decrease in cophenetic correlation coefficient, and from these choose the k with the highest average silhouette value.
References
[1] Monti, S., Tamayo, P., Mesirov, J. & Golub, T.R., Consensus Clustering: A Resampling-Based Method for Class Discovery and Visualization of Gene Expression Microarray Data, Machine Learning:91-118 (2003)
[2] Wilkerson M and Waltman P, ConsensusClusterPlus: ConsensusClusterPlus
[3] Rousseeuw, P.J., Silhouettes: A graphical aid to the interpretation and validation of cluster analysis., J. Comput. Appl. Math. 20:53-65 (1987)
[4] Brunet, J.P., Tamayo, P., Golub, T.R. & Mesirov, J.P., Metagenes and molecular pattern discovery using matrix factorization, Proc Natl Acad Sci U S A 12(101):4164-9 (2004)
[6] RSEM