Clustering of miR mature expression: consensus hierarchical
Uveal Melanoma (Primary solid tumor)
13 July 2018  |  None
Maintainer Information
Maintained by Hailei Zhang (Broad Institute)
Overview
Introduction

This pipeline calculates clusters based on consensus hierarchical clustering with agglomerative ward linkage[1],[2]. This pipeline has the following features:

  1. Classify samples into consensus clusters.

  2. Determine differentially expressed marker miRs for each subtype.

Summary

Median absolute deviation (MAD) was used to select 278 most variable miRs. Consensus ward linkage hierarchical clustering of 80 samples and 278 miRs identified 5 subtypes with the stability of the clustering increasing for k = 2 to k = 10.

Results
miR expression patterns of molecular subtypes

Figure 1.  Get High-res Image Samples were separated into 5 clusters. Shown are 80 samples and 872 marker miRs. The color bar of the row indicates the marker miRs for the corresponding cluster.

Figure 2.  Get High-res Image Heatmap with a standard hierarchical clustering for 80 samples and the 278 most variable miRs. *The NA values were changed to 0 for this figure.

Silhouette widths, Cophenetic Correlation Coefficients and Consensus matrix

Figure 3.  Get High-res Image The silhouette width was calculated for each sample and each value of k. The left upper panel shows the average silhouette width across all samples for each tested k (left upper panel). The left lower panel shows the Cophenetic Correlation Coefficients for each tested k. The right panel shows assignments of clusters to samples and the k silhouette width of each sample for the most robust clustering.

Figure 4.  Get High-res Image The consensus matrix after clustering shows 5 clusters with limited overlap between clusters.

Samples assignment with silhouette width

Table 1.  Get Full Table List of samples with 5 subtypes and silhouette width.

SampleName cluster silhouetteValue
TCGA-RZ-AB0B-01A-11R-A40B-13 1 0.23
TCGA-V4-A9E7-01A-11R-A40B-13 1 0.26
TCGA-V4-A9EE-01A-11R-A40B-13 1 0.091
TCGA-V4-A9EQ-01A-11R-A40B-13 1 0.17
TCGA-V4-A9ES-01A-11R-A40B-13 1 0.24
TCGA-V4-A9EU-01A-11R-A40B-13 1 -0.027
TCGA-V4-A9EV-01A-11R-A40B-13 1 0.16
TCGA-V4-A9F1-01A-11R-A40B-13 1 0.19
TCGA-V4-A9F3-01A-11R-A40B-13 1 0.17
TCGA-V4-A9F5-01A-11R-A40B-13 1 0.16

Table 2.  Get Full Table List of samples belonging to each cluster in different k clusters.

SampleName K=2 K=3 K=4 K=5 K=6 K=7 K=8 K=9 K=10
TCGA-RZ-AB0B-01A-11R-A40B-13 1 1 1 1 1 1 1 1 1
TCGA-V3-A9ZX-01A-11R-A40B-13 1 2 2 2 2 2 2 2 2
TCGA-V3-A9ZY-01A-11R-A40B-13 2 3 3 3 3 3 3 3 3
TCGA-V4-A9E5-01A-11R-A40B-13 2 3 4 4 4 4 4 4 4
TCGA-V4-A9E7-01A-11R-A40B-13 1 1 1 1 5 5 5 5 5
TCGA-V4-A9E8-01A-11R-A40B-13 2 3 4 5 6 2 2 6 6
TCGA-V4-A9E9-01A-11R-A40B-13 2 3 4 5 6 2 6 7 7
TCGA-V4-A9EA-01A-11R-A40B-13 2 3 4 5 6 2 6 7 7
TCGA-V4-A9EC-01A-11R-A40B-13 2 3 3 3 3 3 3 3 3
TCGA-V4-A9ED-01A-11R-A40B-13 1 2 2 2 2 2 2 6 6
Marker miRs of each subtype

Samples most representative of the clusters, hereby called core samples were identified based on positive silhouette width, indicating higher similarity to their own class than to any other class member. Core samples were used to select differentially expressed marker miRs for each subtype by comparing the subclass versus the other subclasses, using Student's t-test.

Table 3.  Get Full Table List of marker miRs with p <= 0.05 (The positive value of column difference means miR is upregulated in this subtype and vice versa).

Hybridization.REF p difference q subclass
HSA-MIR-142-3P|MIMAT0000434 0.000064 2.6 0.00065 1
HSA-MIR-142-5P|MIMAT0000433 0.000045 2.5 0.0005 1
HSA-MIR-592|MIMAT0003260 4.5e-06 2.1 0.000075 1
HSA-MIR-10B-5P|MIMAT0000254 0.016 1.9 0.051 1
HSA-MIR-708-5P|MIMAT0004926 0.000054 1.8 0.00057 1
HSA-MIR-503-5P|MIMAT0002874 2.5e-07 1.8 7.1e-06 1
HSA-MIR-155-5P|MIMAT0000646 0.000012 1.8 0.00016 1
HSA-MIR-374A-5P|MIMAT0000727 0.000031 1.8 0.00036 1
HSA-MIR-19A-3P|MIMAT0000073 0.000075 1.7 0.00073 1
HSA-MIR-199A-5P|MIMAT0000231 0.00017 1.7 0.0013 1
HSA-MIR-21-5P|MIMAT0000076 2.6e-07 1.7 7.1e-06 1
HSA-MIR-155-3P|MIMAT0004658 0.00028 1.7 0.0019 1
HSA-MIR-577|MIMAT0003242 0.00015 1.7 0.0013 1
HSA-MIR-452-5P|MIMAT0001635 1.1e-06 1.6 0.000023 1
HSA-MIR-653-5P|MIMAT0003328 0.00018 1.6 0.0014 1
HSA-MIR-708-3P|MIMAT0004927 0.0033 1.5 0.016 1
HSA-MIR-224-5P|MIMAT0000281 0.00016 1.5 0.0013 1
HSA-MIR-144-5P|MIMAT0004600 0.0091 1.5 0.034 1
HSA-MIR-21-3P|MIMAT0004494 0.00019 1.5 0.0014 1
HSA-MIR-18A-5P|MIMAT0000072 3.6e-06 1.4 0.000064 1
HSA-MIR-301A-3P|MIMAT0000688 0.00058 1.4 0.0035 1
HSA-MIR-15A-5P|MIMAT0000068 1.5e-10 1.4 8.7e-09 1
HSA-MIR-126-5P|MIMAT0000444 2.9e-07 1.4 7.6e-06 1
HSA-MIR-132-3P|MIMAT0000426 4.8e-07 1.4 0.000011 1
HSA-MIR-212-3P|MIMAT0000269 0.000057 1.4 0.00059 1
HSA-MIR-887-3P|MIMAT0004951 0.0012 1.4 0.0065 1
HSA-MIR-362-3P|MIMAT0004683 6.7e-07 1.3 0.000015 1
HSA-MIR-340-5P|MIMAT0004692 1.7e-06 1.3 0.000033 1
HSA-MIR-302B-3P|MIMAT0000715 0.026 1.3 0.078 1
HSA-LET-7B-3P|MIMAT0004482 3e-10 1.3 1.7e-08 1
HSA-MIR-188-5P|MIMAT0000457 5.3e-08 1.3 2.1e-06 1
HSA-MIR-150-5P|MIMAT0000451 0.048 1.2 0.13 1
HSA-MIR-199A-3P|MIMAT0000232 0.0086 1.2 0.033 1
HSA-MIR-199B-3P|MIMAT0004563 0.0087 1.2 0.033 1
HSA-MIR-29B-3P|MIMAT0000100 0.00039 1.2 0.0025 1
HSA-MIR-937-3P|MIMAT0004980 0.0042 1.1 0.019 1
HSA-MIR-193A-3P|MIMAT0000459 0.00016 1.1 0.0013 1
HSA-MIR-424-5P|MIMAT0001341 0.00041 1.1 0.0026 1
HSA-MIR-195-5P|MIMAT0000461 0.000057 1 0.00059 1
HSA-MIR-497-5P|MIMAT0002820 5e-06 1 0.000077 1
HSA-MIR-200B-3P|MIMAT0000318 0.00012 1 0.0011 1
HSA-MIR-146B-5P|MIMAT0002809 0.024 1 0.07 1
HSA-MIR-381-3P|MIMAT0000736 0.013 0.99 0.043 1
HSA-MIR-2355-5P|MIMAT0016895 0.0047 0.99 0.021 1
HSA-MIR-33A-3P|MIMAT0004506 0.00019 0.99 0.0014 1
HSA-MIR-20A-5P|MIMAT0000075 0.0012 0.98 0.0065 1
HSA-MIR-3940-3P|MIMAT0018356 0.0053 0.93 0.023 1
HSA-LET-7A-3P|MIMAT0004481 0.00033 0.92 0.0022 1
HSA-MIR-502-5P|MIMAT0002873 0.000019 0.87 0.00023 1
HSA-MIR-3912-3P|MIMAT0018186 0.0012 0.87 0.0068 1
HSA-MIR-27A-3P|MIMAT0000084 0.0003 0.86 0.002 1
HSA-MIR-450B-5P|MIMAT0004909 0.0063 0.85 0.025 1
HSA-MIR-101-3P|MIMAT0000099 0.04 0.82 0.11 1
HSA-MIR-3191-3P|MIMAT0015075 0.0051 0.82 0.023 1
HSA-MIR-200C-3P|MIMAT0000617 0.00021 0.81 0.0016 1
HSA-MIR-346|MIMAT0000773 0.02 0.81 0.061 1
HSA-MIR-542-5P|MIMAT0003340 0.003 0.8 0.014 1
HSA-MIR-590-3P|MIMAT0004801 0.011 0.8 0.038 1
HSA-MIR-145-3P|MIMAT0004601 0.01 0.79 0.037 1
HSA-MIR-223-3P|MIMAT0000280 0.017 0.79 0.053 1
HSA-MIR-19B-3P|MIMAT0000074 0.023 0.78 0.068 1
HSA-MIR-542-3P|MIMAT0003389 0.0028 0.77 0.013 1
HSA-MIR-3065-5P|MIMAT0015066 0.011 0.75 0.037 1
HSA-MIR-16-1-3P|MIMAT0004489 0.006 0.74 0.025 1
HSA-MIR-3065-3P|MIMAT0015378 0.0047 0.74 0.021 1
HSA-MIR-504-5P|MIMAT0002875 0.045 0.74 0.12 1
HSA-LET-7F-1-3P|MIMAT0004486 0.0015 0.73 0.0082 1
HSA-MIR-106B-5P|MIMAT0000680 0.000074 0.73 0.00073 1
HSA-MIR-24-2-5P|MIMAT0004497 0.00013 0.73 0.0011 1
HSA-MIR-16-5P|MIMAT0000069 0.00027 0.72 0.0019 1
HSA-MIR-330-5P|MIMAT0004693 0.014 0.69 0.046 1
HSA-MIR-374B-5P|MIMAT0004955 0.013 0.69 0.044 1
HSA-MIR-188-3P|MIMAT0004613 0.0092 0.69 0.034 1
HSA-MIR-450A-5P|MIMAT0001545 0.0097 0.68 0.035 1
HSA-MIR-132-5P|MIMAT0004594 0.0077 0.66 0.03 1
HSA-MIR-24-3P|MIMAT0000080 0.000026 0.65 0.0003 1
HSA-MIR-365A-3P|MIMAT0000710 0.0026 0.64 0.013 1
HSA-MIR-195-3P|MIMAT0004615 0.0093 0.64 0.034 1
HSA-MIR-590-5P|MIMAT0003258 0.05 0.63 0.13 1
HSA-MIR-103A-2-5P|MIMAT0009196 0.0052 0.61 0.023 1
HSA-MIR-215-5P|MIMAT0000272 0.009 0.61 0.034 1
HSA-MIR-766-3P|MIMAT0003888 0.0097 0.6 0.035 1
HSA-MIR-660-5P|MIMAT0003338 0.00036 0.6 0.0023 1
HSA-MIR-148B-5P|MIMAT0004699 0.0023 0.6 0.012 1
HSA-MIR-30B-5P|MIMAT0000420 0.014 0.59 0.046 1
HSA-MIR-148B-3P|MIMAT0000759 0.00022 0.59 0.0016 1
HSA-MIR-193B-3P|MIMAT0002819 0.023 0.59 0.068 1
HSA-MIR-92B-3P|MIMAT0003218 0.0087 0.57 0.033 1
HSA-MIR-532-5P|MIMAT0002888 0.0014 0.56 0.0077 1
HSA-MIR-330-3P|MIMAT0000751 0.037 0.55 0.1 1
HSA-MIR-27A-5P|MIMAT0004501 0.0057 0.54 0.024 1
HSA-MIR-29B-1-5P|MIMAT0004514 0.02 0.53 0.061 1
HSA-MIR-17-5P|MIMAT0000070 0.0062 0.53 0.025 1
HSA-MIR-454-3P|MIMAT0003885 0.0063 0.52 0.025 1
HSA-MIR-29A-5P|MIMAT0004503 0.013 0.51 0.043 1
HSA-MIR-30D-5P|MIMAT0000245 0.0096 0.49 0.035 1
HSA-MIR-342-3P|MIMAT0000753 0.011 0.48 0.038 1
HSA-MIR-500B-5P|MIMAT0016925 0.0077 0.46 0.03 1
HSA-MIR-500A-5P|MIMAT0004773 0.0078 0.46 0.03 1
HSA-MIR-652-3P|MIMAT0003322 0.04 0.44 0.11 1
HSA-MIR-22-3P|MIMAT0000077 0.032 0.39 0.092 1
HSA-MIR-103A-3P|MIMAT0000101 0.0061 0.37 0.025 1
HSA-MIR-671-5P|MIMAT0003880 0.04 0.37 0.11 1
HSA-MIR-769-5P|MIMAT0003886 0.047 -0.31 0.12 1
HSA-LET-7D-5P|MIMAT0000065 0.029 -0.32 0.084 1
HSA-MIR-98-5P|MIMAT0000096 0.017 -0.33 0.054 1
HSA-MIR-339-3P|MIMAT0004702 0.0057 -0.35 0.024 1
HSA-MIR-505-3P|MIMAT0002876 0.048 -0.38 0.13 1
HSA-MIR-106B-3P|MIMAT0004672 0.021 -0.39 0.064 1
HSA-MIR-152-3P|MIMAT0000438 0.029 -0.4 0.085 1
HSA-MIR-92A-1-5P|MIMAT0004507 0.047 -0.41 0.12 1
HSA-MIR-93-3P|MIMAT0004509 0.013 -0.43 0.044 1
HSA-MIR-181C-3P|MIMAT0004559 0.036 -0.44 0.1 1
HSA-MIR-17-3P|MIMAT0000071 0.017 -0.44 0.054 1
HSA-MIR-7-1-3P|MIMAT0004553 0.025 -0.46 0.073 1
HSA-MIR-26B-5P|MIMAT0000083 0.021 -0.49 0.064 1
HSA-MIR-616-3P|MIMAT0004805 0.028 -0.49 0.081 1
HSA-MIR-2110|MIMAT0010133 0.05 -0.49 0.13 1
HSA-MIR-3917|MIMAT0018191 0.0099 -0.5 0.035 1
HSA-MIR-320A|MIMAT0000510 0.036 -0.52 0.1 1
HSA-MIR-181D-5P|MIMAT0002821 0.02 -0.52 0.061 1
HSA-MIR-1180-3P|MIMAT0005825 0.017 -0.52 0.054 1
HSA-MIR-1287-5P|MIMAT0005878 0.0066 -0.53 0.026 1
HSA-MIR-3684|MIMAT0018112 0.042 -0.55 0.11 1
HSA-MIR-627-5P|MIMAT0003296 0.027 -0.56 0.079 1
HSA-MIR-744-5P|MIMAT0004945 0.0054 -0.56 0.023 1
HSA-LET-7I-5P|MIMAT0000415 0.00015 -0.57 0.0013 1
HSA-MIR-320B|MIMAT0005792 0.033 -0.58 0.092 1
HSA-MIR-331-5P|MIMAT0004700 0.0083 -0.59 0.032 1
HSA-MIR-3605-3P|MIMAT0017982 0.011 -0.59 0.037 1
HSA-LET-7D-3P|MIMAT0004484 0.00061 -0.6 0.0037 1
HSA-MIR-140-5P|MIMAT0000431 0.012 -0.61 0.04 1
HSA-MIR-576-5P|MIMAT0003241 0.0092 -0.62 0.034 1
HSA-MIR-95-3P|MIMAT0000094 0.0055 -0.62 0.023 1
HSA-MIR-26A-5P|MIMAT0000082 0.00066 -0.62 0.0039 1
HSA-MIR-138-5P|MIMAT0000430 0.038 -0.63 0.11 1
HSA-LET-7G-5P|MIMAT0000414 4.9e-06 -0.63 0.000077 1
HSA-MIR-3928-3P|MIMAT0018205 0.00089 -0.63 0.0051 1
HSA-MIR-629-5P|MIMAT0004810 1.1e-06 -0.63 0.000023 1
HSA-MIR-140-3P|MIMAT0004597 0.0018 -0.65 0.0093 1
HSA-MIR-30E-3P|MIMAT0000693 0.003 -0.65 0.014 1
HSA-MIR-550A-5P|MIMAT0004800 0.018 -0.66 0.056 1
HSA-MIR-1271-5P|MIMAT0005796 0.015 -0.67 0.048 1
HSA-MIR-186-5P|MIMAT0000456 0.000087 -0.68 0.00081 1
HSA-MIR-3136-5P|MIMAT0015003 0.037 -0.68 0.1 1
HSA-MIR-26A-2-3P|MIMAT0004681 0.045 -0.68 0.12 1
HSA-MIR-191-5P|MIMAT0000440 9.2e-06 -0.68 0.00014 1
HSA-MIR-320C|MIMAT0005793 0.0078 -0.7 0.03 1
HSA-MIR-455-3P|MIMAT0004784 0.0033 -0.71 0.015 1
HSA-MIR-3158-3P|MIMAT0015032 0.014 -0.72 0.046 1
HSA-MIR-203A-3P|MIMAT0000264 0.038 -0.75 0.11 1
HSA-MIR-28-5P|MIMAT0000085 3e-06 -0.75 0.000056 1
HSA-MIR-92A-3P|MIMAT0000092 0.00039 -0.76 0.0025 1
HSA-MIR-146A-5P|MIMAT0000449 0.00027 -0.77 0.0019 1
HSA-MIR-25-3P|MIMAT0000081 0.000095 -0.77 0.00087 1
HSA-MIR-296-5P|MIMAT0000690 0.00092 -0.79 0.0052 1
HSA-MIR-29B-2-5P|MIMAT0004515 0.00038 -0.8 0.0025 1
HSA-MIR-26A-1-3P|MIMAT0004499 0.01 -0.81 0.036 1
HSA-MIR-378A-3P|MIMAT0000732 0.00079 -0.85 0.0046 1
HSA-MIR-363-3P|MIMAT0000707 0.018 -0.87 0.055 1
HSA-MIR-491-5P|MIMAT0002807 0.00015 -0.89 0.0013 1
HSA-MIR-199B-5P|MIMAT0000263 0.0058 -0.9 0.024 1
HSA-MIR-605-5P|MIMAT0003273 0.011 -0.91 0.039 1
HSA-MIR-2114-5P|MIMAT0011156 0.0094 -0.91 0.034 1
HSA-MIR-548S|MIMAT0014987 0.0054 -0.92 0.023 1
HSA-MIR-378C|MIMAT0016847 0.0022 -0.94 0.011 1
HSA-MIR-1226-3P|MIMAT0005577 0.0021 -0.96 0.011 1
HSA-MIR-1284|MIMAT0005941 0.00076 -0.96 0.0045 1
HSA-MIR-29C-5P|MIMAT0004673 0.000079 -0.97 0.00076 1
HSA-LET-7A-2-3P|MIMAT0010195 0.02 -0.97 0.062 1
HSA-MIR-676-5P|MIMAT0018203 0.0047 -0.97 0.021 1
HSA-MIR-26B-3P|MIMAT0004500 0.000019 -0.99 0.00023 1
HSA-MIR-335-3P|MIMAT0004703 0.0082 -1 0.032 1
HSA-MIR-378A-5P|MIMAT0000731 0.000011 -1 0.00015 1
HSA-MIR-375|MIMAT0000728 0.0026 -1 0.013 1
HSA-MIR-191-3P|MIMAT0001618 0.000052 -1 0.00056 1
HSA-MIR-138-1-3P|MIMAT0004607 0.0039 -1 0.018 1
HSA-MIR-3150B-3P|MIMAT0018194 0.03 -1 0.085 1
HSA-MIR-28-3P|MIMAT0004502 2.6e-08 -1 1.1e-06 1
HSA-MIR-30A-3P|MIMAT0000088 0.0018 -1.1 0.0096 1
HSA-MIR-320D|MIMAT0006764 0.0025 -1.1 0.013 1
HSA-MIR-211-5P|MIMAT0000268 0.000033 -1.1 0.00037 1
HSA-MIR-328-3P|MIMAT0000752 0.000098 -1.1 0.00089 1
HSA-MIR-30C-1-3P|MIMAT0004674 0.000012 -1.2 0.00016 1
HSA-MIR-2116-3P|MIMAT0011161 0.000016 -1.2 0.0002 1
HSA-MIR-1468-5P|MIMAT0006789 0.00027 -1.2 0.0019 1
HSA-MIR-222-5P|MIMAT0004569 0.0031 -1.2 0.015 1
HSA-MIR-100-5P|MIMAT0000098 0.0021 -1.2 0.011 1
HSA-MIR-1910-5P|MIMAT0007884 0.00026 -1.2 0.0019 1
HSA-MIR-1262|MIMAT0005914 2.6e-07 -1.2 7.1e-06 1
HSA-MIR-197-3P|MIMAT0000227 2.2e-12 -1.2 1.4e-10 1
HSA-MIR-1249-3P|MIMAT0005901 0.00017 -1.3 0.0013 1
HSA-MIR-1248|MIMAT0005900 0.00082 -1.3 0.0048 1
HSA-MIR-3170|MIMAT0015045 0.00024 -1.3 0.0018 1
HSA-MIR-20B-3P|MIMAT0004752 0.00051 -1.4 0.0032 1
HSA-MIR-125B-1-3P|MIMAT0004592 0.0022 -1.4 0.011 1
HSA-MIR-30C-2-3P|MIMAT0004550 1e-05 -1.4 0.00015 1
HSA-MIR-221-5P|MIMAT0004568 0.0053 -1.4 0.023 1
HSA-MIR-181A-5P|MIMAT0000256 1.2e-06 -1.4 0.000023 1
HSA-MIR-130A-5P|MIMAT0004593 0.00057 -1.4 0.0035 1
HSA-MIR-181B-5P|MIMAT0000257 2.6e-07 -1.5 7.1e-06 1
HSA-MIR-219A-1-3P|MIMAT0004567 3.1e-07 -1.5 7.8e-06 1
HSA-MIR-187-3P|MIMAT0000262 0.013 -1.6 0.044 1
HSA-MIR-181A-2-3P|MIMAT0004558 1e-05 -1.6 0.00015 1
HSA-MIR-383-5P|MIMAT0000738 0.044 -1.6 0.12 1
HSA-MIR-1296-5P|MIMAT0005794 0.00016 -1.6 0.0013 1
HSA-MIR-222-3P|MIMAT0000279 0.00094 -1.6 0.0053 1
HSA-MIR-99A-3P|MIMAT0004511 0.000015 -1.6 0.00019 1
HSA-MIR-3125|MIMAT0014988 0.015 -1.7 0.048 1
HSA-MIR-873-5P|MIMAT0004953 0.000084 -1.7 0.00079 1
HSA-MIR-3200-3P|MIMAT0015085 0.000016 -1.8 0.0002 1
HSA-MIR-125B-5P|MIMAT0000423 5.1e-06 -1.9 0.000077 1
HSA-MIR-125B-2-3P|MIMAT0004603 4.2e-06 -2 0.000071 1
HSA-MIR-99A-5P|MIMAT0000097 4.8e-07 -2.1 0.000011 1
HSA-MIR-221-3P|MIMAT0000278 0.00017 -2.1 0.0013 1
HSA-LET-7C-5P|MIMAT0000064 5.7e-08 -2.2 2.1e-06 1
HSA-MIR-548V|MIMAT0015020 3.1e-06 -2.5 0.000056 1
HSA-MIR-1270|MIMAT0005924 2e-07 -2.7 6.6e-06 1
HSA-MIR-935|MIMAT0004978 7.6e-08 -2.8 2.7e-06 1
HSA-MIR-514B-5P|MIMAT0015087 6.1e-10 -4 3.1e-08 1
HSA-MIR-513B-5P|MIMAT0005788 1.5e-09 -4.2 6.7e-08 1
HSA-MIR-514A-3P|MIMAT0002883 2.9e-13 -4.5 4e-11 1
HSA-MIR-513A-5P|MIMAT0002877 1.8e-12 -4.6 1.3e-10 1
HSA-MIR-509-3-5P|MIMAT0004975 4e-13 -4.9 4e-11 1
HSA-MIR-508-5P|MIMAT0004778 3.6e-13 -5 4e-11 1
HSA-MIR-506-3P|MIMAT0002878 2.9e-14 -5 5.7e-12 1
HSA-MIR-509-3P|MIMAT0002881 1.7e-14 -5 5e-12 1
HSA-MIR-508-3P|MIMAT0002880 6.8e-15 -5.1 4.1e-12 1
HSA-MIR-513C-5P|MIMAT0005789 1.1e-12 -5.1 9.8e-11 1
HSA-MIR-124-3P|MIMAT0000422 0.014 2.7 0.071 2
HSA-MIR-1247-5P|MIMAT0005899 0.0026 2.2 0.025 2
HSA-MIR-105-5P|MIMAT0000102 0.037 1.9 0.13 2
HSA-MIR-199A-3P|MIMAT0000232 0.00093 1.9 0.014 2
HSA-MIR-199B-3P|MIMAT0004563 0.00095 1.9 0.014 2
HSA-MIR-204-5P|MIMAT0000265 0.0075 1.9 0.048 2
HSA-MIR-217|MIMAT0000274 0.0065 1.9 0.045 2
HSA-MIR-183-5P|MIMAT0000261 0.02 1.8 0.089 2
HSA-MIR-433-3P|MIMAT0001627 0.00056 1.8 0.012 2
HSA-MIR-182-5P|MIMAT0000259 0.013 1.8 0.067 2
HSA-MIR-199A-5P|MIMAT0000231 0.0021 1.8 0.022 2
HSA-MIR-767-5P|MIMAT0003882 0.041 1.8 0.14 2
HSA-MIR-134-5P|MIMAT0000447 0.00027 1.8 0.0078 2
HSA-MIR-539-5P|MIMAT0003163 0.0011 1.7 0.014 2
HSA-MIR-129-2-3P|MIMAT0004605 0.00029 1.7 0.0079 2
HSA-MIR-383-5P|MIMAT0000738 0.029 1.7 0.11 2
HSA-MIR-96-5P|MIMAT0000095 0.038 1.6 0.13 2
HSA-MIR-382-5P|MIMAT0000737 0.0014 1.6 0.016 2
HSA-MIR-346|MIMAT0000773 1.3e-06 1.6 0.00077 2
HSA-MIR-154-5P|MIMAT0000452 0.0012 1.5 0.014 2
HSA-MIR-379-5P|MIMAT0000733 0.00097 1.5 0.014 2
HSA-MIR-127-3P|MIMAT0000446 0.0014 1.5 0.016 2
HSA-MIR-937-3P|MIMAT0004980 0.00069 1.5 0.012 2
HSA-MIR-184|MIMAT0000454 0.00058 1.5 0.012 2
HSA-MIR-9-5P|MIMAT0000441 0.038 1.5 0.13 2
HSA-MIR-375|MIMAT0000728 0.001 1.5 0.014 2
HSA-MIR-323B-3P|MIMAT0015050 0.014 1.4 0.07 2
HSA-MIR-1275|MIMAT0005929 0.00067 1.4 0.012 2
HSA-MIR-431-3P|MIMAT0004757 0.0097 1.4 0.056 2
HSA-MIR-362-5P|MIMAT0000705 0.00047 1.3 0.011 2
HSA-MIR-708-3P|MIMAT0004927 0.0048 1.3 0.036 2
HSA-MIR-758-3P|MIMAT0003879 0.0025 1.3 0.024 2
HSA-MIR-143-5P|MIMAT0004599 0.000025 1.3 0.0017 2
HSA-MIR-432-5P|MIMAT0002814 0.0077 1.3 0.049 2
HSA-MIR-145-3P|MIMAT0004601 0.000029 1.2 0.0017 2
HSA-MIR-487B-3P|MIMAT0003180 0.016 1.2 0.076 2
HSA-MIR-891A-5P|MIMAT0004902 0.0073 1.2 0.048 2
HSA-MIR-493-5P|MIMAT0002813 0.0007 1.2 0.012 2
HSA-MIR-409-3P|MIMAT0001639 0.0028 1.2 0.026 2
HSA-MIR-136-5P|MIMAT0000448 0.017 1.2 0.079 2
HSA-MIR-370-3P|MIMAT0000722 0.011 1.2 0.059 2
HSA-MIR-887-3P|MIMAT0004951 0.01 1.2 0.059 2
HSA-MIR-409-5P|MIMAT0001638 0.009 1.1 0.053 2
HSA-MIR-149-5P|MIMAT0000450 4.3e-06 1.1 0.0013 2
HSA-MIR-143-3P|MIMAT0000435 0.000088 1.1 0.0038 2
HSA-MIR-127-5P|MIMAT0004604 0.027 1.1 0.11 2
HSA-MIR-129-5P|MIMAT0000242 0.00071 1.1 0.012 2
HSA-MIR-708-5P|MIMAT0004926 0.019 1.1 0.088 2
HSA-MIR-489-3P|MIMAT0002805 0.036 1.1 0.13 2
HSA-MIR-216A-5P|MIMAT0000273 0.04 1 0.14 2
HSA-MIR-200A-5P|MIMAT0001620 0.0032 1 0.028 2
HSA-MIR-206|MIMAT0000462 0.022 1 0.093 2
HSA-MIR-3651|MIMAT0018071 0.002 1 0.021 2
HSA-MIR-99B-3P|MIMAT0004678 0.00019 1 0.0061 2
HSA-MIR-145-5P|MIMAT0000437 0.0011 0.95 0.014 2
HSA-MIR-543|MIMAT0004954 0.019 0.95 0.087 2
HSA-MIR-369-5P|MIMAT0001621 0.037 0.95 0.13 2
HSA-MIR-200B-5P|MIMAT0004571 0.012 0.92 0.063 2
HSA-MIR-214-5P|MIMAT0004564 0.0044 0.91 0.034 2
HSA-MIR-496|MIMAT0002818 0.035 0.9 0.13 2
HSA-MIR-3183|MIMAT0015063 0.0039 0.89 0.032 2
HSA-MIR-760|MIMAT0004957 0.0032 0.87 0.028 2
HSA-MIR-3198|MIMAT0015083 0.04 0.87 0.14 2
HSA-MIR-139-3P|MIMAT0004552 0.0013 0.86 0.016 2
HSA-MIR-3622A-3P|MIMAT0018004 0.023 0.86 0.096 2
HSA-MIR-337-3P|MIMAT0000754 0.039 0.85 0.14 2
HSA-MIR-218-5P|MIMAT0000275 0.00068 0.84 0.012 2
HSA-MIR-511-5P|MIMAT0002808 0.018 0.83 0.084 2
HSA-MIR-155-5P|MIMAT0000646 0.039 0.82 0.14 2
HSA-MIR-940|MIMAT0004983 0.0044 0.8 0.034 2
HSA-MIR-877-5P|MIMAT0004949 0.019 0.77 0.087 2
HSA-MIR-7-5P|MIMAT0000252 0.02 0.77 0.089 2
HSA-MIR-326|MIMAT0000756 0.031 0.76 0.12 2
HSA-MIR-627-5P|MIMAT0003296 0.023 0.76 0.096 2
HSA-MIR-200B-3P|MIMAT0000318 0.011 0.72 0.062 2
HSA-MIR-193A-5P|MIMAT0004614 0.00054 0.72 0.012 2
HSA-MIR-146B-5P|MIMAT0002809 0.021 0.71 0.092 2
HSA-MIR-212-3P|MIMAT0000269 0.0082 0.7 0.05 2
HSA-MIR-421|MIMAT0003339 0.021 0.69 0.092 2
HSA-MIR-345-5P|MIMAT0000772 0.0028 0.68 0.025 2
HSA-MIR-1248|MIMAT0005900 0.026 0.66 0.11 2
HSA-MIR-99B-5P|MIMAT0000689 0.0074 0.64 0.048 2
HSA-MIR-328-3P|MIMAT0000752 0.02 0.63 0.089 2
HSA-MIR-22-5P|MIMAT0004495 0.0072 0.62 0.048 2
HSA-MIR-146B-3P|MIMAT0004766 0.015 0.6 0.073 2
HSA-LET-7B-5P|MIMAT0000063 0.012 0.59 0.064 2
HSA-MIR-26B-5P|MIMAT0000083 0.0039 0.59 0.032 2
HSA-MIR-132-5P|MIMAT0004594 0.0042 0.59 0.034 2
HSA-MIR-24-1-5P|MIMAT0000079 0.0083 0.58 0.05 2
HSA-MIR-330-5P|MIMAT0004693 0.04 0.58 0.14 2
HSA-MIR-27B-5P|MIMAT0004588 0.0043 0.57 0.034 2
HSA-MIR-125A-3P|MIMAT0004602 0.017 0.56 0.079 2
HSA-MIR-128-3P|MIMAT0000424 0.00066 0.54 0.012 2
HSA-MIR-1301-3P|MIMAT0005797 0.0081 0.54 0.05 2
HSA-MIR-491-5P|MIMAT0002807 0.039 0.53 0.14 2
HSA-MIR-1976|MIMAT0009451 0.028 0.53 0.11 2
HSA-MIR-331-5P|MIMAT0004700 0.011 0.52 0.059 2
HSA-MIR-1254|MIMAT0005905 0.032 0.51 0.12 2
HSA-MIR-501-3P|MIMAT0004774 0.048 0.5 0.15 2
HSA-LET-7E-5P|MIMAT0000066 0.021 0.47 0.092 2
HSA-MIR-98-5P|MIMAT0000096 0.0032 0.47 0.028 2
HSA-MIR-29B-1-5P|MIMAT0004514 0.029 0.46 0.11 2
HSA-MIR-92B-3P|MIMAT0003218 0.022 0.45 0.094 2
HSA-MIR-628-5P|MIMAT0004809 0.043 0.43 0.14 2
HSA-MIR-1307-3P|MIMAT0005951 0.034 0.43 0.13 2
HSA-MIR-27B-3P|MIMAT0000419 0.015 0.42 0.075 2
HSA-MIR-664A-5P|MIMAT0005948 0.013 0.41 0.064 2
HSA-MIR-30B-3P|MIMAT0004589 0.046 0.39 0.15 2
HSA-MIR-423-3P|MIMAT0001340 0.031 0.35 0.12 2
HSA-MIR-769-5P|MIMAT0003886 0.047 -0.35 0.15 2
HSA-MIR-181A-5P|MIMAT0000256 0.04 -0.41 0.14 2
HSA-MIR-589-3P|MIMAT0003256 0.045 -0.52 0.15 2
HSA-MIR-500B-5P|MIMAT0016925 0.04 -0.53 0.14 2
HSA-MIR-500A-5P|MIMAT0004773 0.04 -0.53 0.14 2
HSA-MIR-643|MIMAT0003313 0.011 -0.56 0.062 2
HSA-MIR-30C-5P|MIMAT0000244 0.0083 -0.57 0.05 2
HSA-MIR-15A-5P|MIMAT0000068 0.046 -0.59 0.15 2
HSA-MIR-28-5P|MIMAT0000085 0.0074 -0.6 0.048 2
HSA-MIR-20B-5P|MIMAT0001413 0.046 -0.61 0.15 2
HSA-MIR-30B-5P|MIMAT0000420 0.012 -0.63 0.063 2
HSA-MIR-3065-3P|MIMAT0015378 0.02 -0.64 0.09 2
HSA-MIR-331-3P|MIMAT0000760 0.03 -0.64 0.12 2
HSA-MIR-374B-3P|MIMAT0004956 0.015 -0.66 0.072 2
HSA-MIR-942-5P|MIMAT0004985 0.0024 -0.67 0.024 2
HSA-MIR-548O-3P|MIMAT0005919 0.023 -0.67 0.096 2
HSA-MIR-181C-5P|MIMAT0000258 0.024 -0.7 0.098 2
HSA-MIR-106B-5P|MIMAT0000680 0.0096 -0.7 0.055 2
HSA-MIR-148A-3P|MIMAT0000243 0.0073 -0.71 0.048 2
HSA-MIR-1271-5P|MIMAT0005796 0.043 -0.71 0.14 2
HSA-MIR-194-3P|MIMAT0004671 0.0065 -0.72 0.045 2
HSA-MIR-34B-3P|MIMAT0004676 0.028 -0.74 0.11 2
HSA-MIR-455-5P|MIMAT0003150 0.012 -0.77 0.063 2
HSA-MIR-374B-5P|MIMAT0004955 0.02 -0.79 0.089 2
HSA-MIR-29B-3P|MIMAT0000100 0.0049 -0.79 0.036 2
HSA-MIR-2355-5P|MIMAT0016895 0.039 -0.82 0.14 2
HSA-MIR-20A-3P|MIMAT0004493 0.022 -0.84 0.093 2
HSA-MIR-106A-5P|MIMAT0000103 0.01 -0.84 0.059 2
HSA-MIR-126-5P|MIMAT0000444 0.015 -0.89 0.073 2
HSA-MIR-34C-3P|MIMAT0004677 0.031 -0.89 0.12 2
HSA-MIR-192-5P|MIMAT0000222 0.000032 -0.96 0.0017 2
HSA-MIR-140-3P|MIMAT0004597 0.00041 -0.97 0.01 2
HSA-MIR-34C-5P|MIMAT0000686 0.036 -0.98 0.13 2
HSA-LET-7G-3P|MIMAT0004584 0.0079 -0.98 0.049 2
HSA-MIR-424-5P|MIMAT0001341 0.0062 -1 0.044 2
HSA-MIR-18A-5P|MIMAT0000072 0.006 -1 0.043 2
HSA-MIR-192-3P|MIMAT0004543 0.0049 -1 0.036 2
HSA-MIR-140-5P|MIMAT0000431 0.002 -1 0.021 2
HSA-MIR-155-3P|MIMAT0004658 0.031 -1 0.12 2
HSA-MIR-340-5P|MIMAT0004692 0.006 -1 0.043 2
HSA-MIR-590-3P|MIMAT0004801 0.0095 -1 0.055 2
HSA-MIR-503-5P|MIMAT0002874 0.004 -1.1 0.033 2
HSA-MIR-29C-3P|MIMAT0000681 0.0011 -1.1 0.014 2
HSA-MIR-590-5P|MIMAT0003258 0.0022 -1.1 0.022 2
HSA-MIR-142-5P|MIMAT0000433 0.036 -1.1 0.13 2
HSA-MIR-624-5P|MIMAT0003293 0.001 -1.1 0.014 2
HSA-MIR-142-3P|MIMAT0000434 0.036 -1.1 0.13 2
HSA-MIR-20A-5P|MIMAT0000075 0.0031 -1.2 0.028 2
HSA-MIR-1277-3P|MIMAT0005933 0.00013 -1.2 0.005 2
HSA-MIR-32-5P|MIMAT0000090 0.012 -1.2 0.063 2
HSA-MIR-30A-5P|MIMAT0000087 0.00024 -1.2 0.0072 2
HSA-MIR-302B-3P|MIMAT0000715 0.0051 -1.3 0.037 2
HSA-MIR-130A-3P|MIMAT0000425 0.000057 -1.3 0.0029 2
HSA-MIR-362-3P|MIMAT0004683 0.000015 -1.3 0.0016 2
HSA-MIR-101-5P|MIMAT0004513 8e-05 -1.3 0.0037 2
HSA-MIR-374A-3P|MIMAT0004688 0.00071 -1.3 0.012 2
HSA-MIR-651-5P|MIMAT0003321 0.0014 -1.3 0.016 2
HSA-MIR-30E-5P|MIMAT0000692 0.000021 -1.4 0.0017 2
HSA-MIR-19B-3P|MIMAT0000074 0.00015 -1.4 0.0051 2
HSA-MIR-194-5P|MIMAT0000460 7.3e-06 -1.4 0.0015 2
HSA-MIR-219A-5P|MIMAT0000276 0.00067 -1.5 0.012 2
HSA-MIR-548V|MIMAT0015020 0.0015 -1.6 0.017 2
HSA-MIR-506-3P|MIMAT0002878 0.028 -1.6 0.11 2
HSA-MIR-101-3P|MIMAT0000099 0.00037 -1.6 0.0097 2
HSA-MIR-301A-3P|MIMAT0000688 0.000027 -2 0.0017 2
HSA-MIR-509-3-5P|MIMAT0004975 0.0082 -2.1 0.05 2
HSA-MIR-513C-5P|MIMAT0005789 0.0027 -2.2 0.025 2
HSA-MIR-509-3P|MIMAT0002881 0.0038 -2.2 0.032 2
HSA-MIR-514A-3P|MIMAT0002883 0.0013 -2.3 0.016 2
HSA-MIR-509-5P|MIMAT0004779 0.00052 -2.3 0.012 2
HSA-MIR-508-3P|MIMAT0002880 0.0025 -2.3 0.024 2
HSA-MIR-507|MIMAT0002879 0.0073 -2.3 0.048 2
HSA-MIR-513B-5P|MIMAT0005788 0.00016 -2.5 0.0053 2
HSA-MIR-374A-5P|MIMAT0000727 0.000016 -2.5 0.0016 2
HSA-MIR-19A-3P|MIMAT0000073 0.00014 -2.5 0.0051 2
HSA-MIR-513A-5P|MIMAT0002877 0.0011 -2.6 0.014 2
HSA-MIR-508-5P|MIMAT0004778 0.002 -2.6 0.021 2
HSA-MIR-514B-5P|MIMAT0015087 0.00076 -2.6 0.012 2
HSA-MIR-514B-3P|MIMAT0015088 1e-05 -2.8 0.0015 2
HSA-MIR-935|MIMAT0004978 0.00018 3.3 0.0055 3
HSA-MIR-203A-3P|MIMAT0000264 0.000016 2.9 0.00099 3
HSA-MIR-34B-3P|MIMAT0004676 0.041 2.2 0.21 3
HSA-MIR-34C-5P|MIMAT0000686 0.033 2.1 0.19 3
HSA-MIR-3125|MIMAT0014988 0.02 2 0.14 3
HSA-MIR-618|MIMAT0003287 0.0018 2 0.032 3
HSA-MIR-125B-1-3P|MIMAT0004592 0.0011 1.9 0.025 3
HSA-MIR-129-1-3P|MIMAT0004548 0.0016 1.9 0.032 3
HSA-MIR-548V|MIMAT0015020 3.6e-06 1.8 0.0004 3
HSA-MIR-548B-5P|MIMAT0004798 0.011 1.7 0.097 3
HSA-MIR-181A-3P|MIMAT0000270 0.022 1.6 0.15 3
HSA-MIR-582-3P|MIMAT0004797 0.013 1.6 0.11 3
HSA-MIR-211-5P|MIMAT0000268 0.0017 1.6 0.032 3
HSA-MIR-34B-5P|MIMAT0000685 0.029 1.6 0.18 3
HSA-MIR-125B-5P|MIMAT0000423 3.6e-10 1.5 1e-07 3
HSA-MIR-548B-3P|MIMAT0003254 0.00017 1.5 0.0055 3
HSA-MIR-378C|MIMAT0016847 0.000032 1.4 0.0015 3
HSA-MIR-3200-3P|MIMAT0015085 0.018 1.4 0.14 3
HSA-MIR-99A-3P|MIMAT0004511 0.00077 1.4 0.02 3
HSA-MIR-20B-5P|MIMAT0001413 0.014 1.3 0.11 3
HSA-MIR-548O-3P|MIMAT0005919 0.01 1.3 0.092 3
HSA-MIR-219A-1-3P|MIMAT0004567 3.2e-10 1.3 1e-07 3
HSA-MIR-181C-5P|MIMAT0000258 0.004 1.2 0.049 3
HSA-MIR-125B-2-3P|MIMAT0004603 8e-06 1.2 0.00076 3
HSA-MIR-29B-2-5P|MIMAT0004515 0.0052 1.2 0.055 3
HSA-MIR-1249-3P|MIMAT0005901 0.0034 1.2 0.047 3
HSA-MIR-30A-5P|MIMAT0000087 0.021 1.2 0.14 3
HSA-MIR-3170|MIMAT0015045 0.000015 1.2 0.00099 3
HSA-MIR-4326|MIMAT0016888 0.0042 1.2 0.049 3
HSA-MIR-221-5P|MIMAT0004568 0.000014 1.2 0.00099 3
HSA-MIR-1285-3P|MIMAT0005876 0.019 1.2 0.14 3
HSA-MIR-1271-5P|MIMAT0005796 2.8e-06 1.1 0.00039 3
HSA-MIR-181D-5P|MIMAT0002821 0.0035 1.1 0.047 3
HSA-MIR-29C-3P|MIMAT0000681 0.0043 1.1 0.049 3
HSA-MIR-34A-3P|MIMAT0004557 0.00012 1.1 0.0046 3
HSA-MIR-30C-2-3P|MIMAT0004550 0.00071 1.1 0.019 3
HSA-MIR-99A-5P|MIMAT0000097 0.0025 1.1 0.041 3
HSA-MIR-26A-1-3P|MIMAT0004499 0.000038 1 0.0016 3
HSA-MIR-222-3P|MIMAT0000279 0.0013 1 0.029 3
HSA-MIR-34A-5P|MIMAT0000255 0.016 1 0.12 3
HSA-MIR-181C-3P|MIMAT0004559 0.004 1 0.049 3
HSA-MIR-30A-3P|MIMAT0000088 0.033 1 0.19 3
HSA-MIR-181A-5P|MIMAT0000256 0.033 0.99 0.19 3
HSA-LET-7G-3P|MIMAT0004584 0.019 0.96 0.14 3
HSA-MIR-296-3P|MIMAT0004679 0.041 0.96 0.21 3
HSA-MIR-1468-5P|MIMAT0006789 0.013 0.93 0.11 3
HSA-MIR-193B-5P|MIMAT0004767 0.0042 0.93 0.049 3
HSA-MIR-589-3P|MIMAT0003256 0.025 0.91 0.16 3
HSA-MIR-874-3P|MIMAT0004911 0.014 0.87 0.11 3
HSA-MIR-30C-5P|MIMAT0000244 0.03 0.85 0.18 3
HSA-MIR-3909|MIMAT0018183 0.037 0.81 0.21 3
HSA-MIR-378A-3P|MIMAT0000732 0.0027 0.8 0.042 3
HSA-MIR-101-5P|MIMAT0004513 0.039 0.78 0.21 3
HSA-MIR-221-3P|MIMAT0000278 0.022 0.78 0.15 3
HSA-MIR-30C-1-3P|MIMAT0004674 0.0035 0.77 0.047 3
HSA-MIR-130A-3P|MIMAT0000425 0.0032 0.76 0.046 3
HSA-MIR-28-3P|MIMAT0004502 0.00014 0.74 0.0048 3
HSA-MIR-29C-5P|MIMAT0004673 0.026 0.74 0.16 3
HSA-MIR-589-5P|MIMAT0004799 0.012 0.72 0.11 3
HSA-MIR-192-5P|MIMAT0000222 0.0018 0.71 0.032 3
HSA-MIR-148A-3P|MIMAT0000243 0.00021 0.7 0.0063 3
HSA-MIR-942-5P|MIMAT0004985 0.013 0.7 0.11 3
HSA-MIR-625-3P|MIMAT0004808 0.027 0.69 0.17 3
HSA-LET-7C-5P|MIMAT0000064 0.0027 0.69 0.042 3
HSA-MIR-378A-5P|MIMAT0000731 0.0031 0.67 0.046 3
HSA-MIR-616-5P|MIMAT0003284 0.0057 0.66 0.058 3
HSA-MIR-194-5P|MIMAT0000460 0.041 0.66 0.22 3
HSA-MIR-374B-3P|MIMAT0004956 0.011 0.66 0.1 3
HSA-MIR-19B-1-5P|MIMAT0004491 0.018 0.65 0.14 3
HSA-LET-7G-5P|MIMAT0000414 0.00092 0.64 0.022 3
HSA-MIR-550A-5P|MIMAT0004800 0.05 0.63 0.23 3
HSA-MIR-301A-3P|MIMAT0000688 0.023 0.63 0.15 3
HSA-MIR-30E-3P|MIMAT0000693 0.00034 0.62 0.0096 3
HSA-MIR-186-5P|MIMAT0000456 0.0045 0.6 0.049 3
HSA-MIR-502-5P|MIMAT0002873 0.049 0.58 0.23 3
HSA-MIR-616-3P|MIMAT0004805 0.0068 0.57 0.067 3
HSA-MIR-1179|MIMAT0005824 0.037 0.56 0.21 3
HSA-MIR-28-5P|MIMAT0000085 0.005 0.56 0.054 3
HSA-MIR-3189-3P|MIMAT0015071 0.018 0.55 0.14 3
HSA-MIR-331-3P|MIMAT0000760 0.05 0.55 0.23 3
HSA-MIR-574-3P|MIMAT0003239 0.0024 0.54 0.041 3
HSA-MIR-339-3P|MIMAT0004702 0.0038 0.54 0.048 3
HSA-LET-7I-3P|MIMAT0004585 0.042 0.48 0.22 3
HSA-MIR-361-5P|MIMAT0000703 0.036 0.43 0.21 3
HSA-MIR-197-3P|MIMAT0000227 0.049 0.38 0.23 3
HSA-MIR-93-5P|MIMAT0000093 0.0075 -0.34 0.072 3
HSA-MIR-151A-5P|MIMAT0004697 0.0084 -0.4 0.081 3
HSA-MIR-3679-5P|MIMAT0018104 0.0055 -0.5 0.058 3
HSA-MIR-151A-3P|MIMAT0000757 0.023 -0.53 0.15 3
HSA-MIR-30D-3P|MIMAT0004551 0.014 -0.6 0.11 3
HSA-MIR-199B-5P|MIMAT0000263 0.0096 -0.64 0.09 3
HSA-MIR-330-5P|MIMAT0004693 0.039 -0.65 0.21 3
HSA-MIR-132-5P|MIMAT0004594 0.046 -0.66 0.23 3
HSA-MIR-145-5P|MIMAT0000437 0.046 -0.69 0.23 3
HSA-MIR-7-5P|MIMAT0000252 0.028 -0.72 0.17 3
HSA-MIR-129-2-3P|MIMAT0004605 0.04 -0.74 0.21 3
HSA-MIR-362-5P|MIMAT0000705 0.049 -0.82 0.23 3
HSA-LET-7B-5P|MIMAT0000063 0.048 -0.82 0.23 3
HSA-MIR-212-3P|MIMAT0000269 0.045 -0.83 0.23 3
HSA-MIR-21-5P|MIMAT0000076 0.039 -0.87 0.21 3
HSA-MIR-32-3P|MIMAT0004505 0.00088 -0.87 0.022 3
HSA-MIR-433-3P|MIMAT0001627 0.043 -1 0.22 3
HSA-MIR-758-3P|MIMAT0003879 0.02 -1 0.14 3
HSA-MIR-301B-3P|MIMAT0004958 1.7e-06 -1 0.00032 3
HSA-MIR-577|MIMAT0003242 0.026 -1 0.16 3
HSA-MIR-143-3P|MIMAT0000435 0.049 -1.2 0.23 3
HSA-MIR-196A-5P|MIMAT0000226 0.04 -1.4 0.21 3
HSA-MIR-124-5P|MIMAT0004591 0.0036 -1.4 0.047 3
HSA-MIR-513B-5P|MIMAT0005788 0.021 -1.5 0.14 3
HSA-MIR-708-5P|MIMAT0004926 0.0068 -1.5 0.067 3
HSA-MIR-379-5P|MIMAT0000733 0.047 -1.6 0.23 3
HSA-MIR-10B-3P|MIMAT0004556 0.0016 -1.6 0.032 3
HSA-MIR-940|MIMAT0004983 0.0044 -1.7 0.049 3
HSA-MIR-539-5P|MIMAT0003163 0.021 -1.8 0.14 3
HSA-MIR-592|MIMAT0003260 0.015 -2 0.12 3
HSA-MIR-509-5P|MIMAT0004779 0.003 -2.1 0.046 3
HSA-MIR-937-3P|MIMAT0004980 0.0097 -2.2 0.09 3
HSA-MIR-199B-3P|MIMAT0004563 0.000022 -2.4 0.0011 3
HSA-MIR-199A-3P|MIMAT0000232 0.000022 -2.4 0.0011 3
HSA-MIR-196B-5P|MIMAT0001080 0.0024 -2.6 0.041 3
HSA-MIR-199A-5P|MIMAT0000231 0.00012 -2.6 0.0046 3
HSA-MIR-514A-3P|MIMAT0002883 3.5e-11 5.2 7e-09 4
HSA-MIR-508-5P|MIMAT0004778 4.9e-11 5.1 7.3e-09 4
HSA-MIR-508-3P|MIMAT0002880 1.6e-11 5 4.7e-09 4
HSA-MIR-509-3-5P|MIMAT0004975 3.3e-10 5 4e-08 4
HSA-MIR-509-3P|MIMAT0002881 7.7e-12 5 4.6e-09 4
HSA-MIR-506-3P|MIMAT0002878 3.3e-09 4.4 2.8e-07 4
HSA-MIR-513C-5P|MIMAT0005789 1.7e-08 4.3 1.1e-06 4
HSA-MIR-513A-5P|MIMAT0002877 1.3e-08 4.1 9.8e-07 4
HSA-MIR-513B-5P|MIMAT0005788 0.00018 2.7 0.0024 4
HSA-MIR-509-5P|MIMAT0004779 0.00045 2.7 0.0046 4
HSA-MIR-514B-5P|MIMAT0015087 0.00074 2.5 0.0063 4
HSA-MIR-507|MIMAT0002879 0.0016 2.4 0.012 4
HSA-MIR-19A-3P|MIMAT0000073 1.2e-06 2.1 0.000046 4
HSA-MIR-335-5P|MIMAT0000765 0.00051 1.9 0.0049 4
HSA-MIR-374A-5P|MIMAT0000727 3.5e-06 1.9 0.00011 4
HSA-MIR-219A-5P|MIMAT0000276 0.0013 1.8 0.01 4
HSA-MIR-101-3P|MIMAT0000099 6.1e-06 1.8 0.00016 4
HSA-MIR-1270|MIMAT0005924 0.000017 1.8 0.00036 4
HSA-MIR-514B-3P|MIMAT0015088 0.011 1.8 0.048 4
HSA-MIR-651-5P|MIMAT0003321 2.2e-06 1.7 0.000077 4
HSA-MIR-101-5P|MIMAT0004513 5.4e-06 1.7 0.00015 4
HSA-MIR-335-3P|MIMAT0004703 0.00068 1.6 0.006 4
HSA-MIR-99A-5P|MIMAT0000097 1.8e-08 1.5 1.1e-06 4
HSA-MIR-20A-5P|MIMAT0000075 1.3e-07 1.5 6.8e-06 4
HSA-MIR-19B-3P|MIMAT0000074 1.9e-06 1.5 0.000072 4
HSA-MIR-374A-3P|MIMAT0004688 0.000016 1.4 0.00036 4
HSA-MIR-30E-5P|MIMAT0000692 4e-05 1.3 0.00073 4
HSA-MIR-30A-5P|MIMAT0000087 0.000081 1.3 0.0013 4
HSA-MIR-548V|MIMAT0015020 0.0049 1.3 0.026 4
HSA-MIR-582-3P|MIMAT0004797 0.017 1.2 0.07 4
HSA-MIR-140-5P|MIMAT0000431 0.00028 1.2 0.0032 4
HSA-MIR-130A-3P|MIMAT0000425 8.3e-10 1.2 8.2e-08 4
HSA-MIR-20A-3P|MIMAT0004493 4.3e-06 1.2 0.00013 4
HSA-MIR-99A-3P|MIMAT0004511 0.000036 1.2 0.00068 4
HSA-MIR-29C-3P|MIMAT0000681 0.000017 1.1 0.00036 4
HSA-MIR-100-5P|MIMAT0000098 0.0072 1.1 0.035 4
HSA-MIR-935|MIMAT0004978 0.048 1.1 0.15 4
HSA-MIR-181C-5P|MIMAT0000258 0.0019 1.1 0.013 4
HSA-MIR-125B-2-3P|MIMAT0004603 0.00014 1.1 0.002 4
HSA-MIR-194-5P|MIMAT0000460 0.0017 1.1 0.012 4
HSA-MIR-106A-5P|MIMAT0000103 0.00026 1.1 0.0031 4
HSA-MIR-32-5P|MIMAT0000090 0.016 1 0.066 4
HSA-MIR-2116-3P|MIMAT0011161 0.0019 1 0.013 4
HSA-LET-7C-5P|MIMAT0000064 0.00021 1 0.0026 4
HSA-MIR-624-5P|MIMAT0003293 0.00025 1 0.003 4
HSA-MIR-301A-3P|MIMAT0000688 0.02 0.98 0.077 4
HSA-MIR-590-5P|MIMAT0003258 0.00053 0.96 0.0049 4
HSA-MIR-20B-5P|MIMAT0001413 0.014 0.95 0.059 4
HSA-MIR-125B-5P|MIMAT0000423 0.011 0.93 0.047 4
HSA-MIR-18A-5P|MIMAT0000072 0.0037 0.92 0.021 4
HSA-MIR-455-5P|MIMAT0003150 0.0041 0.92 0.023 4
HSA-MIR-374B-3P|MIMAT0004956 0.00026 0.91 0.0031 4
HSA-MIR-140-3P|MIMAT0004597 0.0019 0.89 0.013 4
HSA-MIR-106B-5P|MIMAT0000680 0.000035 0.89 0.00068 4
HSA-MIR-222-3P|MIMAT0000279 0.014 0.88 0.057 4
HSA-MIR-1271-5P|MIMAT0005796 0.007 0.87 0.034 4
HSA-MIR-590-3P|MIMAT0004801 0.0025 0.87 0.016 4
HSA-MIR-222-5P|MIMAT0004569 0.0027 0.86 0.017 4
HSA-MIR-33A-5P|MIMAT0000091 0.034 0.84 0.12 4
HSA-MIR-181A-5P|MIMAT0000256 0.0058 0.83 0.029 4
HSA-MIR-491-3P|MIMAT0004765 0.0058 0.79 0.029 4
HSA-LET-7G-3P|MIMAT0004584 0.012 0.78 0.051 4
HSA-MIR-28-5P|MIMAT0000085 0.00017 0.77 0.0023 4
HSA-MIR-219A-1-3P|MIMAT0004567 0.0025 0.77 0.016 4
HSA-MIR-181B-5P|MIMAT0000257 0.0012 0.77 0.01 4
HSA-MIR-3154|MIMAT0015028 0.035 0.75 0.12 4
HSA-MIR-126-5P|MIMAT0000444 0.016 0.75 0.066 4
HSA-MIR-374B-5P|MIMAT0004955 0.0078 0.75 0.037 4
HSA-MIR-192-3P|MIMAT0004543 0.023 0.74 0.085 4
HSA-MIR-340-5P|MIMAT0004692 0.008 0.74 0.038 4
HSA-MIR-1249-3P|MIMAT0005901 0.012 0.72 0.051 4
HSA-MIR-17-5P|MIMAT0000070 8.2e-06 0.72 0.0002 4
HSA-MIR-181A-2-3P|MIMAT0004558 0.015 0.69 0.062 4
HSA-MIR-1296-5P|MIMAT0005794 0.0057 0.68 0.029 4
HSA-MIR-363-3P|MIMAT0000707 0.044 0.66 0.14 4
HSA-MIR-3913-5P|MIMAT0018187 0.033 0.61 0.11 4
HSA-MIR-192-5P|MIMAT0000222 0.025 0.58 0.091 4
HSA-MIR-17-3P|MIMAT0000071 0.0031 0.58 0.019 4
HSA-MIR-181D-5P|MIMAT0002821 0.043 0.53 0.14 4
HSA-MIR-30B-5P|MIMAT0000420 0.0044 0.51 0.025 4
HSA-MIR-19B-1-5P|MIMAT0004491 0.0013 0.48 0.01 4
HSA-MIR-30C-5P|MIMAT0000244 0.029 0.45 0.1 4
HSA-LET-7G-5P|MIMAT0000414 0.022 0.36 0.084 4
HSA-MIR-92A-3P|MIMAT0000092 0.037 0.36 0.12 4
HSA-MIR-340-3P|MIMAT0000750 0.043 -0.28 0.14 4
HSA-MIR-98-5P|MIMAT0000096 0.035 -0.29 0.12 4
HSA-MIR-664A-5P|MIMAT0005948 0.036 -0.33 0.12 4
HSA-MIR-27B-3P|MIMAT0000419 0.0047 -0.34 0.026 4
HSA-MIR-128-3P|MIMAT0000424 0.0089 -0.37 0.041 4
HSA-MIR-671-5P|MIMAT0003880 0.03 -0.4 0.1 4
HSA-MIR-532-3P|MIMAT0004780 0.025 -0.41 0.092 4
HSA-MIR-24-1-5P|MIMAT0000079 0.0062 -0.44 0.031 4
HSA-MIR-342-5P|MIMAT0004694 0.045 -0.44 0.14 4
HSA-MIR-148B-3P|MIMAT0000759 0.00053 -0.44 0.0049 4
HSA-LET-7A-3P|MIMAT0004481 0.015 -0.45 0.06 4
HSA-MIR-24-3P|MIMAT0000080 0.003 -0.45 0.018 4
HSA-MIR-103A-3P|MIMAT0000101 0.0047 -0.46 0.026 4
HSA-LET-7E-5P|MIMAT0000066 0.045 -0.46 0.14 4
HSA-MIR-126-3P|MIMAT0000445 0.0074 -0.48 0.035 4
HSA-MIR-505-5P|MIMAT0004776 0.048 -0.5 0.15 4
HSA-MIR-505-3P|MIMAT0002876 0.031 -0.5 0.11 4
HSA-MIR-342-3P|MIMAT0000753 0.0095 -0.51 0.043 4
HSA-MIR-502-3P|MIMAT0004775 0.00053 -0.51 0.0049 4
HSA-MIR-628-5P|MIMAT0004809 0.033 -0.51 0.11 4
HSA-MIR-877-5P|MIMAT0004949 0.034 -0.53 0.12 4
HSA-MIR-218-5P|MIMAT0000275 0.045 -0.55 0.14 4
HSA-MIR-361-3P|MIMAT0004682 0.00033 -0.56 0.0036 4
HSA-MIR-27B-5P|MIMAT0004588 0.0019 -0.56 0.013 4
HSA-MIR-598-3P|MIMAT0003266 0.0058 -0.57 0.029 4
HSA-MIR-125A-3P|MIMAT0004602 0.0047 -0.57 0.026 4
HSA-MIR-7-5P|MIMAT0000252 0.044 -0.59 0.14 4
HSA-MIR-550A-3P|MIMAT0003257 0.047 -0.6 0.14 4
HSA-MIR-200C-3P|MIMAT0000617 0.012 -0.61 0.053 4
HSA-MIR-24-2-5P|MIMAT0004497 0.0018 -0.63 0.012 4
HSA-MIR-3682-3P|MIMAT0018110 0.035 -0.64 0.12 4
HSA-MIR-345-5P|MIMAT0000772 0.019 -0.65 0.075 4
HSA-MIR-628-3P|MIMAT0003297 0.021 -0.66 0.081 4
HSA-MIR-141-5P|MIMAT0004598 0.013 -0.67 0.054 4
HSA-MIR-652-3P|MIMAT0003322 0.00053 -0.67 0.0049 4
HSA-MIR-193A-5P|MIMAT0004614 0.000011 -0.69 0.00026 4
HSA-MIR-324-5P|MIMAT0000761 0.0026 -0.7 0.017 4
HSA-MIR-200A-3P|MIMAT0000682 0.04 -0.71 0.13 4
HSA-MIR-421|MIMAT0003339 0.0095 -0.71 0.043 4
HSA-MIR-1307-3P|MIMAT0005951 0.000033 -0.73 0.00065 4
HSA-MIR-627-5P|MIMAT0003296 0.0048 -0.74 0.026 4
HSA-MIR-22-3P|MIMAT0000077 0.0016 -0.74 0.012 4
HSA-MIR-29B-1-5P|MIMAT0004514 0.0048 -0.75 0.026 4
HSA-MIR-200B-3P|MIMAT0000318 0.00057 -0.76 0.0051 4
HSA-MIR-99B-5P|MIMAT0000689 0.0032 -0.76 0.019 4
HSA-MIR-760|MIMAT0004957 0.02 -0.8 0.077 4
HSA-MIR-940|MIMAT0004983 0.0017 -0.8 0.012 4
HSA-MIR-502-5P|MIMAT0002873 0.012 -0.81 0.051 4
HSA-MIR-484|MIMAT0002174 0.0054 -0.82 0.028 4
HSA-MIR-369-3P|MIMAT0000721 0.03 -0.83 0.1 4
HSA-MIR-543|MIMAT0004954 0.02 -0.83 0.077 4
HSA-MIR-500A-3P|MIMAT0002871 0.00028 -0.84 0.0032 4
HSA-MIR-132-5P|MIMAT0004594 0.00037 -0.84 0.0039 4
HSA-MIR-1248|MIMAT0005900 0.011 -0.85 0.047 4
HSA-MIR-483-5P|MIMAT0004761 0.043 -0.86 0.14 4
HSA-MIR-1301-3P|MIMAT0005797 0.00019 -0.86 0.0024 4
HSA-MIR-1976|MIMAT0009451 0.00039 -0.86 0.004 4
HSA-MIR-31-5P|MIMAT0000089 0.008 -0.88 0.038 4
HSA-MIR-188-5P|MIMAT0000457 0.0018 -0.91 0.012 4
HSA-MIR-493-5P|MIMAT0002813 0.029 -0.93 0.1 4
HSA-MIR-143-5P|MIMAT0004599 0.012 -0.93 0.051 4
HSA-MIR-4286|MIMAT0016916 0.011 -0.93 0.047 4
HSA-MIR-3065-5P|MIMAT0015066 0.018 -0.94 0.072 4
HSA-MIR-143-3P|MIMAT0000435 0.0014 -0.94 0.011 4
HSA-MIR-150-3P|MIMAT0004610 0.04 -0.94 0.13 4
HSA-MIR-149-5P|MIMAT0000450 0.00037 -0.96 0.0039 4
HSA-MIR-3189-3P|MIMAT0015071 0.018 -0.96 0.072 4
HSA-MIR-675-3P|MIMAT0006790 0.041 -0.96 0.13 4
HSA-MIR-504-5P|MIMAT0002875 0.038 -0.98 0.13 4
HSA-MIR-765|MIMAT0003945 0.026 -0.99 0.094 4
HSA-MIR-581|MIMAT0003246 0.0066 -1 0.033 4
HSA-MIR-135A-5P|MIMAT0000428 0.031 -1 0.11 4
HSA-MIR-200B-5P|MIMAT0004571 0.023 -1 0.085 4
HSA-MIR-3690|MIMAT0018119 0.025 -1 0.092 4
HSA-MIR-501-5P|MIMAT0002872 3.4e-06 -1 0.00011 4
HSA-MIR-145-3P|MIMAT0004601 0.0002 -1.1 0.0026 4
HSA-MIR-330-5P|MIMAT0004693 0.000042 -1.1 0.00074 4
HSA-MIR-212-3P|MIMAT0000269 0.000059 -1.1 0.001 4
HSA-MIR-511-5P|MIMAT0002808 0.0068 -1.1 0.033 4
HSA-MIR-139-3P|MIMAT0004552 0.002 -1.1 0.013 4
HSA-MIR-129-5P|MIMAT0000242 0.00092 -1.1 0.0078 4
HSA-MIR-1237-3P|MIMAT0005592 0.018 -1.1 0.072 4
HSA-MIR-766-3P|MIMAT0003888 0.0003 -1.1 0.0033 4
HSA-MIR-154-5P|MIMAT0000452 0.0083 -1.1 0.038 4
HSA-MIR-99B-3P|MIMAT0004678 0.000081 -1.1 0.0013 4
HSA-MIR-146B-3P|MIMAT0004766 0.0019 -1.1 0.013 4
HSA-MIR-937-3P|MIMAT0004980 0.00071 -1.1 0.0062 4
HSA-MIR-483-3P|MIMAT0002173 0.00014 -1.2 0.002 4
HSA-MIR-501-3P|MIMAT0004774 3.9e-07 -1.2 2e-05 4
HSA-MIR-214-5P|MIMAT0004564 0.0028 -1.2 0.017 4
HSA-MIR-146B-5P|MIMAT0002809 0.0011 -1.2 0.0086 4
HSA-MIR-431-3P|MIMAT0004757 0.005 -1.2 0.026 4
HSA-MIR-1275|MIMAT0005929 0.038 -1.2 0.13 4
HSA-MIR-452-5P|MIMAT0001635 0.000096 -1.3 0.0015 4
HSA-MIR-199B-3P|MIMAT0004563 0.0036 -1.3 0.021 4
HSA-MIR-199A-3P|MIMAT0000232 0.0035 -1.3 0.021 4
HSA-MIR-145-5P|MIMAT0000437 0.000011 -1.3 0.00026 4
HSA-MIR-9-5P|MIMAT0000441 0.026 -1.3 0.093 4
HSA-MIR-224-5P|MIMAT0000281 0.00017 -1.4 0.0023 4
HSA-MIR-22-5P|MIMAT0004495 7.5e-06 -1.4 0.00019 4
HSA-MIR-105-5P|MIMAT0000102 0.045 -1.4 0.14 4
HSA-MIR-369-5P|MIMAT0001621 0.015 -1.5 0.062 4
HSA-MIR-362-5P|MIMAT0000705 9.5e-07 -1.5 0.000041 4
HSA-MIR-199A-5P|MIMAT0000231 0.0016 -1.6 0.012 4
HSA-MIR-346|MIMAT0000773 0.005 -1.6 0.026 4
HSA-MIR-155-5P|MIMAT0000646 0.00015 -1.7 0.0022 4
HSA-MIR-200A-5P|MIMAT0001620 5.1e-07 -1.7 0.000023 4
HSA-MIR-592|MIMAT0003260 0.001 -1.7 0.0083 4
HSA-MIR-150-5P|MIMAT0000451 0.00072 -1.8 0.0062 4
HSA-MIR-708-3P|MIMAT0004927 0.0018 -1.8 0.012 4
HSA-MIR-708-5P|MIMAT0004926 0.000077 -1.9 0.0013 4
HSA-MIR-129-2-3P|MIMAT0004605 0.0029 -2 0.018 4
HSA-MIR-887-3P|MIMAT0004951 0.00047 -2 0.0047 4
HSA-MIR-767-5P|MIMAT0003882 0.0043 -2.1 0.025 4
HSA-MIR-508-5P|MIMAT0004778 7.7e-06 4.8 0.0014 5
HSA-MIR-513C-5P|MIMAT0005789 2e-05 4.6 0.0017 5
HSA-MIR-508-3P|MIMAT0002880 0.000018 4.6 0.0017 5
HSA-MIR-509-3P|MIMAT0002881 9.5e-06 4.5 0.0014 5
HSA-MIR-506-3P|MIMAT0002878 0.000033 4.4 0.0024 5
HSA-MIR-514A-3P|MIMAT0002883 0.00041 3.7 0.017 5
HSA-MIR-509-3-5P|MIMAT0004975 0.0031 3.5 0.045 5
HSA-MIR-196B-5P|MIMAT0001080 0.012 3.2 0.088 5
HSA-MIR-513A-5P|MIMAT0002877 0.0045 3 0.055 5
HSA-MIR-514B-5P|MIMAT0015087 0.0027 2.7 0.045 5
HSA-MIR-513B-5P|MIMAT0005788 0.028 2.2 0.15 5
HSA-MIR-548V|MIMAT0015020 0.0031 1.8 0.045 5
HSA-MIR-514B-3P|MIMAT0015088 0.047 1.6 0.2 5
HSA-MIR-1270|MIMAT0005924 0.012 1.6 0.088 5
HSA-MIR-221-3P|MIMAT0000278 0.000056 1.6 0.0036 5
HSA-MIR-1296-5P|MIMAT0005794 2e-05 1.2 0.0017 5
HSA-MIR-4326|MIMAT0016888 0.0043 1.2 0.054 5
HSA-MIR-197-3P|MIMAT0000227 0.0013 1.2 0.036 5
HSA-MIR-221-5P|MIMAT0004568 0.0012 1.2 0.036 5
HSA-MIR-1468-5P|MIMAT0006789 0.0049 1.2 0.057 5
HSA-MIR-181A-2-3P|MIMAT0004558 0.00016 1.1 0.0072 5
HSA-MIR-1248|MIMAT0005900 0.012 1.1 0.088 5
HSA-MIR-138-1-3P|MIMAT0004607 1.6e-06 1.1 0.00094 5
HSA-MIR-369-5P|MIMAT0001621 0.011 1.1 0.087 5
HSA-MIR-1910-5P|MIMAT0007884 0.024 1 0.14 5
HSA-MIR-141-5P|MIMAT0004598 0.029 1 0.15 5
HSA-MIR-1226-3P|MIMAT0005577 0.003 1 0.045 5
HSA-MIR-222-3P|MIMAT0000279 0.0052 1 0.058 5
HSA-MIR-769-3P|MIMAT0003887 8.4e-06 0.97 0.0014 5
HSA-MIR-935|MIMAT0004978 0.028 0.93 0.15 5
HSA-MIR-211-5P|MIMAT0000268 0.014 0.93 0.095 5
HSA-MIR-362-5P|MIMAT0000705 0.032 0.93 0.16 5
HSA-MIR-28-3P|MIMAT0004502 0.00013 0.93 0.0066 5
HSA-MIR-320B|MIMAT0005792 0.0083 0.9 0.075 5
HSA-MIR-876-5P|MIMAT0004924 0.008 0.9 0.073 5
HSA-MIR-548S|MIMAT0014987 0.014 0.89 0.096 5
HSA-MIR-130A-5P|MIMAT0004593 0.003 0.89 0.045 5
HSA-MIR-320C|MIMAT0005793 0.0092 0.88 0.079 5
HSA-MIR-328-3P|MIMAT0000752 0.045 0.87 0.2 5
HSA-LET-7C-5P|MIMAT0000064 0.0033 0.87 0.046 5
HSA-MIR-186-3P|MIMAT0004612 0.02 0.86 0.12 5
HSA-MIR-219A-1-3P|MIMAT0004567 0.0022 0.86 0.045 5
HSA-MIR-222-5P|MIMAT0004569 0.0086 0.85 0.077 5
HSA-MIR-320A|MIMAT0000510 0.0052 0.83 0.058 5
HSA-MIR-181A-5P|MIMAT0000256 0.0025 0.83 0.045 5
HSA-MIR-455-3P|MIMAT0004784 0.014 0.82 0.097 5
HSA-MIR-99A-3P|MIMAT0004511 0.003 0.82 0.045 5
HSA-MIR-26B-3P|MIMAT0004500 0.011 0.8 0.084 5
HSA-MIR-181B-5P|MIMAT0000257 0.01 0.8 0.084 5
HSA-MIR-1249-3P|MIMAT0005901 0.0015 0.77 0.04 5
HSA-MIR-191-3P|MIMAT0001618 0.018 0.77 0.11 5
HSA-MIR-532-3P|MIMAT0004780 0.0025 0.75 0.045 5
HSA-MIR-191-5P|MIMAT0000440 0.00012 0.73 0.0066 5
HSA-MIR-616-3P|MIMAT0004805 0.0071 0.72 0.068 5
HSA-MIR-1262|MIMAT0005914 0.028 0.71 0.15 5
HSA-MIR-500A-3P|MIMAT0002871 0.0042 0.7 0.054 5
HSA-MIR-378A-5P|MIMAT0000731 0.049 0.7 0.21 5
HSA-MIR-2116-3P|MIMAT0011161 0.03 0.69 0.15 5
HSA-MIR-23B-5P|MIMAT0004587 0.0018 0.65 0.042 5
HSA-MIR-3917|MIMAT0018191 0.033 0.65 0.17 5
HSA-MIR-93-3P|MIMAT0004509 0.00016 0.65 0.0072 5
HSA-MIR-140-3P|MIMAT0004597 0.015 0.63 0.099 5
HSA-MIR-576-5P|MIMAT0003241 0.032 0.59 0.16 5
HSA-MIR-7-1-3P|MIMAT0004553 0.0044 0.59 0.054 5
HSA-MIR-28-5P|MIMAT0000085 0.0036 0.55 0.049 5
HSA-MIR-25-3P|MIMAT0000081 0.02 0.53 0.12 5
HSA-MIR-186-5P|MIMAT0000456 0.011 0.51 0.087 5
HSA-MIR-3136-5P|MIMAT0015003 0.034 0.51 0.17 5
HSA-MIR-505-3P|MIMAT0002876 0.0033 0.51 0.046 5
HSA-MIR-3928-3P|MIMAT0018205 0.05 0.49 0.21 5
HSA-MIR-3615|MIMAT0017994 0.046 0.49 0.2 5
HSA-LET-7D-3P|MIMAT0004484 0.045 0.48 0.2 5
HSA-MIR-769-5P|MIMAT0003886 0.02 0.46 0.12 5
HSA-LET-7G-5P|MIMAT0000414 0.024 0.42 0.14 5
HSA-MIR-148B-3P|MIMAT0000759 0.04 -0.27 0.19 5
HSA-MIR-7-5P|MIMAT0000252 0.043 -0.42 0.2 5
HSA-MIR-24-2-5P|MIMAT0004497 0.0057 -0.42 0.061 5
HSA-MIR-30D-5P|MIMAT0000245 0.044 -0.49 0.2 5
HSA-MIR-24-3P|MIMAT0000080 0.0022 -0.49 0.045 5
HSA-MIR-21-3P|MIMAT0004494 0.042 -0.54 0.2 5
HSA-LET-7E-5P|MIMAT0000066 0.03 -0.58 0.15 5
HSA-MIR-200C-3P|MIMAT0000617 0.043 -0.59 0.2 5
HSA-MIR-92B-3P|MIMAT0003218 0.028 -0.6 0.15 5
HSA-MIR-16-5P|MIMAT0000069 0.002 -0.61 0.044 5
HSA-LET-7A-3P|MIMAT0004481 0.01 -0.62 0.084 5
HSA-MIR-27A-3P|MIMAT0000084 0.00058 -0.63 0.021 5
HSA-MIR-193A-3P|MIMAT0000459 0.017 -0.65 0.11 5
HSA-MIR-29A-5P|MIMAT0004503 0.00098 -0.66 0.031 5
HSA-LET-7F-1-3P|MIMAT0004486 0.039 -0.69 0.19 5
HSA-MIR-3940-3P|MIMAT0018356 0.01 -0.73 0.084 5
HSA-MIR-16-1-3P|MIMAT0004489 0.021 -0.78 0.12 5
HSA-MIR-193B-3P|MIMAT0002819 0.026 -0.82 0.15 5
HSA-MIR-34A-5P|MIMAT0000255 0.0092 -0.82 0.079 5
HSA-MIR-937-3P|MIMAT0004980 0.015 -0.84 0.1 5
HSA-MIR-365A-3P|MIMAT0000710 0.027 -0.84 0.15 5
HSA-MIR-30E-5P|MIMAT0000692 0.031 -0.89 0.16 5
HSA-MIR-17-5P|MIMAT0000070 0.0071 -0.93 0.068 5
HSA-MIR-346|MIMAT0000773 0.0066 -0.94 0.066 5
HSA-LET-7B-3P|MIMAT0004482 0.0065 -0.96 0.066 5
HSA-MIR-497-5P|MIMAT0002820 0.0024 -0.97 0.045 5
HSA-MIR-181C-5P|MIMAT0000258 0.015 -0.99 0.1 5
HSA-MIR-224-5P|MIMAT0000281 0.043 -1 0.2 5
HSA-MIR-212-3P|MIMAT0000269 0.018 -1 0.11 5
HSA-MIR-195-5P|MIMAT0000461 0.0056 -1 0.061 5
HSA-MIR-362-3P|MIMAT0004683 0.021 -1 0.12 5
HSA-MIR-106B-5P|MIMAT0000680 0.0028 -1 0.045 5
HSA-MIR-33A-3P|MIMAT0004506 0.00081 -1.1 0.028 5
HSA-MIR-3166|MIMAT0015040 0.0066 -1.1 0.066 5
HSA-MIR-200B-3P|MIMAT0000318 0.0046 -1.1 0.055 5
HSA-MIR-374A-3P|MIMAT0004688 0.047 -1.1 0.2 5
HSA-MIR-452-5P|MIMAT0001635 0.023 -1.1 0.14 5
HSA-MIR-19B-3P|MIMAT0000074 0.035 -1.2 0.17 5
HSA-MIR-708-3P|MIMAT0004927 0.04 -1.2 0.19 5
HSA-MIR-132-3P|MIMAT0000426 0.0017 -1.2 0.042 5
HSA-MIR-199B-3P|MIMAT0004563 0.01 -1.2 0.084 5
HSA-MIR-199A-3P|MIMAT0000232 0.01 -1.2 0.084 5
HSA-MIR-199A-5P|MIMAT0000231 0.045 -1.2 0.2 5
HSA-MIR-29B-3P|MIMAT0000100 0.0013 -1.2 0.036 5
HSA-MIR-374B-5P|MIMAT0004955 0.025 -1.2 0.14 5
HSA-MIR-142-5P|MIMAT0000433 0.029 -1.3 0.15 5
HSA-MIR-887-3P|MIMAT0004951 0.0076 -1.4 0.071 5
HSA-MIR-340-5P|MIMAT0004692 0.013 -1.4 0.093 5
HSA-MIR-21-5P|MIMAT0000076 0.012 -1.4 0.088 5
HSA-MIR-142-3P|MIMAT0000434 0.013 -1.4 0.094 5
HSA-MIR-15A-5P|MIMAT0000068 0.00053 -1.4 0.02 5
HSA-MIR-33A-5P|MIMAT0000091 0.029 -1.4 0.15 5
HSA-MIR-18A-5P|MIMAT0000072 0.0018 -1.5 0.042 5
HSA-MIR-101-3P|MIMAT0000099 0.0065 -1.6 0.066 5
HSA-MIR-126-5P|MIMAT0000444 0.0026 -1.6 0.045 5
HSA-MIR-301A-3P|MIMAT0000688 0.04 -1.6 0.19 5
HSA-MIR-592|MIMAT0003260 0.0027 -1.7 0.045 5
HSA-MIR-653-5P|MIMAT0003328 0.007 -1.7 0.068 5
HSA-MIR-20A-5P|MIMAT0000075 0.0039 -1.7 0.051 5
HSA-MIR-144-5P|MIMAT0004600 0.012 -1.8 0.088 5
HSA-MIR-374A-5P|MIMAT0000727 0.014 -1.8 0.095 5
HSA-MIR-19A-3P|MIMAT0000073 0.016 -1.8 0.1 5
Methods & Data
Input

miR (MIMATs) of RPM value (reads per million reads aligned to miRBase mature) with log2 transformed was as the input data for the clustering.

  • Input file = TCGA-UVM-TP.expclu.gct

Consensus Hierarchical Clustering

Consensus Hierarchical clustering is a resampling-based clustering. It provides for a method to represent the consensus across multiple runs of a clustering algorithm and to assess the stability of the discovered clusters. To this end, perturbations of the original data are simulated by resampling techniques [1],[2].

Silhouette Width

Silhouette width is defined as the ratio of average distance of each sample to samples in the same cluster to the smallest distance to samples not in the same cluster. If silhouette width is close to 1, it means that sample is well clustered. If silhouette width is close to -1, it means that sample is misclassified[3][5].

Cophenetic Correlation Coefficient and How to select the best cluster

The cophenetic correlation coefficient is computed as the Pearson correlation of two distance matrices:

  1. Distance between samples induced by the consensus matrix.

  2. Distance between samples induced by the linkage used in reordering the consensus matrix.

The cophenetic correlation coefficients and average silhouette values are used to determine the k with the most robust clusterings. From the plot of cophenetic correlation versus k, we select modes and the the point preceding the greatest decrease in cophenetic correlation coefficient, and from these choose the k with the highest average silhouette value.

References
[1] Monti, S., Tamayo, P., Mesirov, J. & Golub, T.R., Consensus Clustering: A Resampling-Based Method for Class Discovery and Visualization of Gene Expression Microarray Data, Machine Learning:91-118 (2003)
[2] Wilkerson M and Waltman P, ConsensusClusterPlus: ConsensusClusterPlus
[3] Rousseeuw, P.J., Silhouettes: A graphical aid to the interpretation and validation of cluster analysis., J. Comput. Appl. Math. 20:53-65 (1987)
[4] Brunet, J.P., Tamayo, P., Golub, T.R. & Mesirov, J.P., Metagenes and molecular pattern discovery using matrix factorization, Proc Natl Acad Sci U S A 12(101):4164-9 (2004)
[6] RSEM