Clinical Features MRNA_CHIERARCHICAL METHYLATION_CNMF METHYLATION_CHIERARCHICAL nCNV (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q amp_1p36.33 24 (24%) 76 0.28998 0.469 0.0203 0.0985 0.01129 0.0621 amp_1p36.13 14 (14%) 86 0.95438 0.973 0.44386 0.603 0.30429 0.485 amp_1q22 42 (42%) 58 0.15644 0.329 9.9999e-06 0.00165 5e-05 0.00236 amp_1q32.2 39 (39%) 61 0.10353 0.271 0.00143 0.0201 0.35675 0.545 amp_2p23.3 27 (27%) 73 0.76893 0.852 0.00447 0.0321 0.00367 0.0288 amp_2q11.1 48 (48%) 52 0.58305 0.715 0.03423 0.131 0.11014 0.282 amp_2q13 27 (27%) 73 0.80726 0.873 0.00288 0.0264 0.00238 0.0264 amp_3p21.31 27 (27%) 73 0.43723 0.596 0.0095999 0.0559 0.088499 0.245 amp_3q26.2 20 (20%) 80 0.13162 0.307 0.00265 0.0264 0.00013 0.00536 amp_3q27.1 27 (27%) 73 0.37114 0.556 3e-05 0.0022 2e-05 0.0022 amp_4p16.3 10 (10%) 90 0.42373 0.59 0.01867 0.092 0.18596 0.365 amp_5q35.2 10 (10%) 90 0.53849 0.691 0.01563 0.0794 0.13981 0.313 amp_6p21.32 44 (44%) 56 0.92205 0.954 0.11862 0.292 0.18444 0.364 amp_6q25.1 17 (17%) 83 0.22282 0.404 0.3738 0.556 0.69113 0.797 amp_7p13 29 (29%) 71 0.40142 0.576 0.00315 0.0278 0.097079 0.263 amp_7q11.23 35 (35%) 65 0.40492 0.576 0.1546 0.329 0.61327 0.741 amp_7q22.1 32 (32%) 68 0.16235 0.335 0.064029 0.201 0.25086 0.429 amp_8q22.3 27 (27%) 73 0.0077299 0.0472 0.31374 0.495 0.65365 0.768 amp_9p24.3 38 (38%) 62 0.071999 0.216 0.10193 0.269 0.46345 0.627 amp_9q34.3 13 (13%) 87 0.40352 0.576 0.02554 0.113 0.4951 0.648 amp_10q23.2 30 (30%) 70 0.76541 0.852 0.79961 0.868 0.51319 0.669 amp_10q26.13 34 (34%) 66 0.48556 0.638 0.0329 0.128 0.04533 0.16 amp_11p15.2 5 (5%) 95 0.23741 0.416 0.11359 0.288 0.2612 0.44 amp_11p11.2 15 (15%) 85 0.87414 0.92 0.0052599 0.0362 0.00335 0.0278 amp_11q13.2 22 (22%) 78 0.92018 0.954 0.0098199 0.0559 0.054819 0.185 amp_11q13.3 19 (19%) 81 0.64577 0.764 0.00019 0.00627 0.00447 0.0321 amp_12p13.33 37 (37%) 63 0.66387 0.773 0.2356 0.416 0.04365 0.159 amp_12q13.2 24 (24%) 76 0.070819 0.215 0.02748 0.118 0.0058699 0.0395 amp_12q24.31 21 (21%) 79 0.28798 0.468 0.061069 0.198 0.1187 0.292 amp_13q12.11 14 (14%) 86 0.16833 0.341 0.33495 0.517 0.00113 0.0169 amp_14q24.2 15 (15%) 85 0.42936 0.593 0.00034 0.00935 0.0073799 0.046 amp_15q24.2 16 (16%) 84 0.4294 0.593 0.11587 0.29 0.39061 0.57 amp_15q26.3 35 (35%) 65 0.62232 0.745 0.57218 0.705 0.62331 0.745 amp_16p11.2 31 (31%) 69 0.098569 0.264 0.13997 0.313 0.061889 0.198 amp_16q22.2 19 (19%) 81 0.9535 0.973 0.19564 0.374 0.35857 0.545 amp_17q12 21 (21%) 79 0.10026 0.267 4e-05 0.0022 0.00267 0.0264 amp_17q24.1 18 (18%) 82 0.17628 0.353 0.0376 0.143 0.17155 0.345 amp_18p11.31 20 (20%) 80 0.093809 0.256 0.25318 0.431 0.40635 0.576 amp_19p13.2 20 (20%) 80 0.60022 0.731 0.00281 0.0264 0.0061499 0.0406 amp_19p13.11 22 (22%) 78 0.23556 0.416 0.02997 0.122 0.04433 0.159 amp_19q12 18 (18%) 82 0.60401 0.733 0.02569 0.113 0.00384 0.0293 amp_19q13.2 18 (18%) 82 0.96241 0.977 0.013 0.0692 0.00346 0.0278 amp_20q13.33 28 (28%) 72 0.47279 0.632 0.00060999 0.0144 0.00166 0.0211 amp_22q13.2 19 (19%) 81 0.95382 0.973 0.21882 0.401 0.43221 0.594 amp_xp11.23 22 (22%) 78 0.76853 0.852 0.27156 0.451 0.53125 0.69 amp_xp11.23 31 (31%) 69 0.32449 0.507 0.56 0.703 0.24063 0.416 amp_xq24 32 (32%) 68 0.87353 0.92 0.78251 0.862 0.20551 0.385 amp_xq28 40 (40%) 60 0.10806 0.279 0.46852 0.628 0.81098 0.875 del_1p36.32 11 (11%) 89 0.75854 0.851 0.14927 0.322 0.47681 0.632 del_1p36.12 16 (16%) 84 0.73206 0.827 0.0092099 0.0553 0.077099 0.224 del_1p13.2 12 (12%) 88 0.32911 0.512 0.00065999 0.0145 0.00205 0.0251 del_1q32.2 13 (13%) 87 0.7228 0.822 0.55852 0.703 0.21028 0.391 del_2q31.2 9 (9%) 91 0.86247 0.92 0.87096 0.92 0.29189 0.47 del_3p26.3 15 (15%) 85 0.40383 0.576 0.02224 0.105 0.071049 0.215 del_3p21.1 13 (13%) 87 0.86701 0.92 0.02441 0.11 0.02887 0.122 del_3p12.2 22 (22%) 78 0.25888 0.438 0.48527 0.638 0.62727 0.747 del_3q25.1 6 (6%) 94 0.69653 0.8 0.56919 0.705 0.1447 0.316 del_3q25.33 5 (5%) 95 0.40166 0.576 0.057639 0.188 0.16378 0.336 del_4p15.31 13 (13%) 87 0.12994 0.306 0.03254 0.128 0.063309 0.201 del_4q13.2 25 (25%) 75 0.056619 0.187 0.070249 0.215 0.081099 0.231 del_4q21.21 24 (24%) 76 0.2029 0.384 0.16508 0.336 0.04372 0.159 del_5q23.1 13 (13%) 87 0.084749 0.237 0.00146 0.0201 0.04687 0.161 del_6q22.31 9 (9%) 91 0.12768 0.305 4e-05 0.0022 0.0070699 0.0454 del_7p22.1 9 (9%) 91 0.57138 0.705 0.317 0.498 0.23923 0.416 del_7q11.21 16 (16%) 84 0.65042 0.767 0.26696 0.447 0.78868 0.865 del_7q11.23 6 (6%) 94 0.34697 0.533 0.8753 0.92 0.83771 0.898 del_7q22.1 11 (11%) 89 0.79811 0.868 0.1377 0.313 0.2366 0.416 del_7q22.1 7 (7%) 93 0.6982 0.8 0.39553 0.575 0.2151 0.397 del_8p23.2 11 (11%) 89 0.13623 0.313 0.00045 0.0114 0.00021 0.0063 del_9p24.3 15 (15%) 85 0.57087 0.705 0.14124 0.313 0.0046 0.0323 del_9p24.1 11 (11%) 89 0.13842 0.313 0.00098999 0.0156 0.00090999 0.015 del_9q21.32 30 (30%) 70 0.33234 0.515 0.064849 0.202 0.14041 0.313 del_10q11.22 6 (6%) 94 0.94441 0.973 0.02268 0.105 0.36882 0.556 del_10q25.3 13 (13%) 87 0.074239 0.219 0.090249 0.248 0.12619 0.304 del_11p15.5 11 (11%) 89 0.63325 0.752 9.9999e-06 0.00165 0.00074999 0.0145 del_11p15.3 15 (15%) 85 0.53614 0.691 0.01384 0.0725 0.00251 0.0264 del_11p11.12 17 (17%) 83 0.61774 0.744 0.1436 0.316 0.54593 0.695 del_11q24.2 14 (14%) 86 1 1 0.0071599 0.0454 0.00083999 0.0146 del_12p13.33 4 (4%) 96 1 1 0.016 0.08 0.18941 0.368 del_12p11.23 10 (10%) 90 0.53805 0.691 0.20383 0.384 0.19596 0.374 del_12q21.32 18 (18%) 82 0.9186 0.954 0.19595 0.374 0.37309 0.556 del_13q12.11 16 (16%) 84 0.41018 0.578 0.59715 0.73 0.27387 0.452 del_13q12.11 14 (14%) 86 0.02681 0.116 0.03237 0.128 0.37996 0.562 del_13q31.3 11 (11%) 89 0.81996 0.881 0.02331 0.107 0.10506 0.273 del_14q32.31 20 (20%) 80 0.55595 0.703 0.22678 0.407 0.12562 0.304 del_15q11.2 20 (20%) 80 0.2207 0.402 0.00288 0.0264 0.15669 0.329 del_15q15.1 26 (26%) 74 0.01061 0.0593 0.21091 0.391 0.41183 0.578 del_15q24.2 28 (28%) 72 0.17981 0.357 0.02957 0.122 0.02985 0.122 del_15q26.3 15 (15%) 85 0.28577 0.467 0.23969 0.416 0.38984 0.57 del_16p13.3 24 (24%) 76 0.18867 0.368 0.65805 0.77 0.15528 0.329 del_16p13.3 9 (9%) 91 0.79664 0.868 0.15735 0.329 0.04403 0.159 del_16p11.2 21 (21%) 79 0.24875 0.428 0.00391 0.0293 0.02189 0.105 del_16q22.1 11 (11%) 89 0.46564 0.627 0.00335 0.0278 0.04626 0.161 del_16q22.2 16 (16%) 84 0.96838 0.98 0.0146 0.0753 0.22668 0.407 del_17p11.2 17 (17%) 83 0.2835 0.465 0.00078999 0.0145 0.00076999 0.0145 del_17q21.32 10 (10%) 90 0.5455 0.695 0.00266 0.0264 0.16219 0.335 del_17q24.1 11 (11%) 89 0.90086 0.941 0.38488 0.567 0.37019 0.556 del_18q22.1 16 (16%) 84 0.47582 0.632 0.077229 0.224 0.04546 0.16 del_19p13.3 23 (23%) 77 0.75891 0.851 0.00016 0.00587 0.00152 0.0201 del_19p13.2 17 (17%) 83 0.95578 0.973 0.12879 0.306 0.7252 0.822 del_19p12 29 (29%) 71 0.98486 0.994 0.78322 0.862 0.54774 0.695 del_19q13.33 13 (13%) 87 1 1 0.00268 0.0264 0.30927 0.491 del_20p13 9 (9%) 91 0.70278 0.802 0.11499 0.29 0.073829 0.219 del_20q13.13 6 (6%) 94 0.56924 0.705 0.68574 0.794 0.27218 0.451 del_22q13.2 22 (22%) 78 0.88738 0.93 0.43672 0.596 0.14729 0.32 del_xp11.23 47 (47%) 53 0.30308 0.485 0.12536 0.304 0.0302 0.122 del_xp11.23 36 (36%) 64 0.76118 0.851 0.03905 0.146 0.0096599 0.0559 del_xp11.22 29 (29%) 71 0.66554 0.773 0.01274 0.0689 0.079619 0.228 del_xq24 32 (32%) 68 0.13228 0.307 0.04927 0.168 0.081929 0.231 del_xq27.3 34 (34%) 66 0.41495 0.58 0.00337 0.0278 0.056629 0.187