Correlation between gene mutation status and molecular subtypes
Uterine Corpus Endometrioid Carcinoma (Primary solid tumor)
04 October 2018 | None
Maintainer Information
Maintained by Broad Institute GDAC (Broad Institute of MIT & Harvard)
Overview
Introduction

This pipeline computes the correlation between significantly recurrent gene mutations and molecular subtypes.

Summary

Testing the association between mutation status of 388 genes and 3 molecular subtypes across 100 patients, no significant finding detected with P value < 0.05 and Q value < 0.25.

- No gene mutations related to molecuar subtypes.

Results
Overview of the results

Table 1. Get Full Table Overview of the association between mutation status of 388 genes and 3 molecular subtypes. Shown in the table are P values (Q values). Thresholded by P value < 0.05 and Q value < 0.25, no significant finding detected.

|  | Clinical Features | MRNA CHIERARCHICAL | METHYLATION CNMF | METHYLATION CHIERARCHICAL
| nMutated (%) | nWild-Type | Fisher's exact test | Fisher's exact test | Fisher's exact test
PTEN | 73 (73%) | 27 | 0.0218 (0.4) | 0.0673 (0.455) | 0.00582 (0.317)
ARID1A | 40 (40%) | 60 | 0.837 (0.94) | 0.00396 (0.317) | 0.0004 (0.255)
KRAS | 32 (32%) | 68 | 0.376 (0.681) | 0.727 (0.885) | 0.432 (0.716)
PIK3R1 | 29 (29%) | 71 | 0.188 (0.559) | 0.181 (0.559) | 0.14 (0.524)
RPL22 | 19 (19%) | 81 | 0.78 (0.917) | 0.0131 (0.395) | 0.00089 (0.255)
LMAN1 | 17 (17%) | 83 | 0.573 (0.782) | 0.0812 (0.47) | 0.0159 (0.395)
CTCF | 23 (23%) | 77 | 0.694 (0.863) | 0.594 (0.801) | 0.109 (0.482)
TP53 | 24 (24%) | 76 | 0.216 (0.575) | 0.0409 (0.416) | 0.0412 (0.416)
SRPR | 16 (16%) | 84 | 0.626 (0.83) | 0.0487 (0.426) | 0.0173 (0.4)
INPPL1 | 22 (22%) | 78 | 0.769 (0.907) | 0.182 (0.559) | 0.112 (0.482)
RNF43 | 14 (14%) | 86 | 0.879 (0.956) | 0.0529 (0.428) | 0.0437 (0.416)
JAK1 | 15 (15%) | 85 | 0.819 (0.932) | 0.00169 (0.255) | 0.006 (0.317)
PHF2 | 16 (16%) | 84 | 0.821 (0.932) | 0.394 (0.687) | 0.0952 (0.473)
FBXW7 | 19 (19%) | 81 | 0.775 (0.912) | 1 (1.00) | 0.486 (0.745)
ACVR2A | 11 (11%) | 89 | 0.564 (0.782) | 0.0157 (0.395) | 0.0273 (0.416)
ADNP | 9 (9%) | 91 | 0.647 (0.843) | 0.947 (0.995) | 0.416 (0.694)
ZFP36L2 | 10 (10%) | 90 | 0.265 (0.632) | 0.117 (0.485) | 0.254 (0.629)
SEC31A | 19 (19%) | 81 | 0.94 (0.991) | 0.014 (0.395) | 0.00097 (0.255)
CMTM1 | 7 (7%) | 93 | 0.708 (0.874) | 0.549 (0.774) | 0.317 (0.649)
TEAD2 | 8 (8%) | 92 | 0.748 (0.894) | 0.843 (0.944) | 0.0521 (0.428)
NCOR2 | 15 (15%) | 85 | 0.701 (0.867) | 0.00136 (0.255) | 0.133 (0.512)
WDTC1 | 9 (9%) | 91 | 0.276 (0.632) | 0.0464 (0.416) | 0.191 (0.561)
NDUFC2 | 6 (6%) | 94 | 0.807 (0.93) | 0.12 (0.489) | 0.606 (0.81)
ZBTB20 | 11 (11%) | 89 | 0.925 (0.984) | 0.185 (0.559) | 0.131 (0.509)
ARID5B | 12 (12%) | 88 | 0.568 (0.782) | 0.0266 (0.416) | 0.169 (0.559)
CEL | 11 (11%) | 89 | 0.621 (0.826) | 0.291 (0.637) | 0.292 (0.637)
RNF145 | 8 (8%) | 92 | 0.745 (0.892) | 0.531 (0.766) | 0.487 (0.745)
BAX | 7 (7%) | 93 | 0.845 (0.944) | 0.0766 (0.466) | 0.211 (0.575)
ARSJ | 6 (6%) | 94 | 0.594 (0.801) | 0.105 (0.477) | 0.193 (0.561)
FAHD2A | 5 (5%) | 95 | 0.378 (0.681) | 0.398 (0.688) | 0.389 (0.685)
KIAA1919 | 8 (8%) | 92 | 0.268 (0.632) | 0.0403 (0.416) | 0.041 (0.416)
PHTF1 | 9 (9%) | 91 | 0.484 (0.745) | 0.0667 (0.455) | 0.0378 (0.416)
ZFHX3 | 21 (21%) | 79 | 0.32 (0.649) | 0.0192 (0.4) | 0.00358 (0.317)
ESRP1 | 10 (10%) | 90 | 0.122 (0.494) | 0.117 (0.485) | 0.0329 (0.416)
PROM1 | 9 (9%) | 91 | 0.569 (0.782) | 0.0139 (0.395) | 0.0522 (0.428)
SFRS15 | 15 (15%) | 85 | 0.936 (0.991) | 0.0464 (0.416) | 0.0447 (0.416)
USP35 | 9 (9%) | 91 | 0.442 (0.725) | 0.256 (0.629) | 0.193 (0.561)
PRRG1 | 6 (6%) | 94 | 0.849 (0.944) | 0.163 (0.559) | 0.276 (0.632)
CTNNB1 | 28 (28%) | 72 | 0.727 (0.885) | 0.0237 (0.4) | 0.00132 (0.255)
HNRNPL | 6 (6%) | 94 | 0.808 (0.93) | 0.57 (0.782) | 0.371 (0.681)
MLL4 | 23 (23%) | 77 | 0.709 (0.876) | 0.0187 (0.4) | 0.0658 (0.455)
SNRK | 6 (6%) | 94 | 0.483 (0.745) | 0.0923 (0.47) | 0.197 (0.565)
OR6C75 | 5 (5%) | 95 | 0.722 (0.884) | 0.0537 (0.428) | 0.382 (0.681)
CCDC73 | 12 (12%) | 88 | 0.784 (0.917) | 0.0201 (0.4) | 0.0422 (0.416)
SLAMF1 | 5 (5%) | 95 | 0.893 (0.965) | 0.335 (0.668) | 0.249 (0.627)
SLC3A2 | 6 (6%) | 94 | 0.849 (0.944) | 1 (1.00) | 0.14 (0.524)
CHD3 | 15 (15%) | 85 | 0.0279 (0.416) | 0.0705 (0.464) | 0.0745 (0.466)
XPOT | 9 (9%) | 91 | 0.226 (0.589) | 0.13 (0.509) | 0.0914 (0.47)
NRIP1 | 8 (8%) | 92 | 0.3 (0.648) | 0.311 (0.649) | 0.182 (0.559)
MAZ | 4 (4%) | 96 | 0.484 (0.745) | 0.183 (0.559) | 0.726 (0.885)
LCE4A | 8 (8%) | 92 | 0.717 (0.884) | 0.44 (0.724) | 0.879 (0.956)
NFE2L2 | 6 (6%) | 94 | 0.77 (0.908) | 0.0909 (0.47) | 0.216 (0.575)
VEGFB | 6 (6%) | 94 | 0.166 (0.559) | 0.0909 (0.47) | 0.494 (0.746)
SENP1 | 6 (6%) | 94 | 0.482 (0.745) | 0.736 (0.889) | 0.791 (0.921)
USP9X | 16 (16%) | 84 | 0.647 (0.843) | 0.324 (0.654) | 0.066 (0.455)
ADAM28 | 6 (6%) | 94 | 0.644 (0.843) | 0.0911 (0.47) | 0.277 (0.632)
SVIL | 14 (14%) | 86 | 0.396 (0.688) | 0.0776 (0.466) | 0.0739 (0.466)
KDM5A | 11 (11%) | 89 | 0.836 (0.94) | 0.0231 (0.4) | 0.0722 (0.466)
PIK3CA | 43 (43%) | 57 | 0.452 (0.729) | 0.219 (0.578) | 0.847 (0.944)
TBC1D23 | 7 (7%) | 93 | 0.978 (1.00) | 0.132 (0.509) | 0.316 (0.649)
C13ORF33 | 6 (6%) | 94 | 0.13 (0.509) | 0.044 (0.416) | 0.148 (0.535)
KIAA0182 | 6 (6%) | 94 | 0.538 (0.771) | 0.103 (0.477) | 0.198 (0.566)
CKAP2 | 5 (5%) | 95 | 0.405 (0.688) | 0.16 (0.557) | 0.354 (0.676)
WBP1 | 6 (6%) | 94 | 0.102 (0.477) | 0.113 (0.482) | 0.111 (0.482)
SAFB2 | 9 (9%) | 91 | 0.275 (0.632) | 0.528 (0.763) | 0.486 (0.745)
XYLT2 | 5 (5%) | 95 | 0.605 (0.81) | 0.00434 (0.317) | 0.181 (0.559)
LRPPRC | 11 (11%) | 89 | 0.668 (0.849) | 0.206 (0.575) | 0.193 (0.561)
SLC12A7 | 5 (5%) | 95 | 0.892 (0.965) | 0.162 (0.559) | 0.181 (0.559)
ZFR | 4 (4%) | 96 | 0.326 (0.656) | 0.354 (0.676) | 0.31 (0.649)
SYNJ2 | 8 (8%) | 92 | 0.886 (0.962) | 0.0756 (0.466) | 0.0795 (0.466)
RALGAPB | 6 (6%) | 94 | 0.667 (0.848) | 0.186 (0.559) | 0.299 (0.647)
TCEB3 | 7 (7%) | 93 | 0.571 (0.782) | 0.288 (0.635) | 0.219 (0.578)
QSOX1 | 5 (5%) | 95 | 0.292 (0.637) | 0.736 (0.889) | 0.474 (0.745)
MFRP | 5 (5%) | 95 | 0.593 (0.801) | 0.364 (0.681) | 0.536 (0.771)
CCDC28A | 4 (4%) | 96 | 0.401 (0.688) | 0.182 (0.559) | 0.576 (0.784)
FGFR2 | 13 (13%) | 87 | 0.494 (0.746) | 0.157 (0.556) | 0.32 (0.649)
ZMIZ1 | 7 (7%) | 93 | 0.241 (0.617) | 0.631 (0.836) | 0.277 (0.632)
ARHGAP35 | 12 (12%) | 88 | 0.455 (0.729) | 0.382 (0.681) | 0.477 (0.745)
TFE3 | 4 (4%) | 96 | 0.202 (0.573) | 0.122 (0.494) | 0.573 (0.782)
SIPA1L1 | 13 (13%) | 87 | 0.892 (0.965) | 0.112 (0.482) | 0.0765 (0.466)
EIF2B3 | 6 (6%) | 94 | 0.848 (0.944) | 0.569 (0.782) | 0.211 (0.575)
NBEAL1 | 9 (9%) | 91 | 0.426 (0.708) | 0.35 (0.676) | 0.116 (0.485)
HPS1 | 6 (6%) | 94 | 0.515 (0.758) | 0.166 (0.559) | 0.275 (0.632)
DOCK3 | 19 (19%) | 81 | 0.676 (0.854) | 0.289 (0.635) | 0.145 (0.534)
SLC16A4 | 4 (4%) | 96 | 0.0648 (0.455) | 0.232 (0.598) | 0.402 (0.688)
DYNC1LI1 | 4 (4%) | 96 | 0.939 (0.991) | 0.0676 (0.455) | 0.105 (0.477)
CHD9 | 11 (11%) | 89 | 0.407 (0.688) | 0.199 (0.566) | 0.0613 (0.454)
RPE65 | 7 (7%) | 93 | 0.64 (0.842) | 0.0409 (0.416) | 0.113 (0.482)
C1QTNF5 | 4 (4%) | 96 | 0.328 (0.659) | 0.124 (0.496) | 0.576 (0.784)
LANCL1 | 5 (5%) | 95 | 0.832 (0.94) | 0.737 (0.889) | 1 (1.00)
TMEM60 | 5 (5%) | 95 | 0.435 (0.721) | 0.918 (0.984) | 0.0679 (0.455)
SLC30A8 | 5 (5%) | 95 | 0.924 (0.984) | 0.0121 (0.395) | 0.00996 (0.395)
U2AF1 | 5 (5%) | 95 | 0.492 (0.746) | 0.188 (0.559) | 0.456 (0.729)
AP1S1 | 6 (6%) | 94 | 0.393 (0.687) | 0.0437 (0.416) | 0.149 (0.536)
TP53BP2 | 8 (8%) | 92 | 0.769 (0.907) | 0.0465 (0.416) | 0.145 (0.534)
ZMYM2 | 12 (12%) | 88 | 0.167 (0.559) | 0.489 (0.746) | 0.155 (0.551)
BRD3 | 6 (6%) | 94 | 0.81 (0.931) | 0.0903 (0.47) | 0.277 (0.632)
C6ORF89 | 5 (5%) | 95 | 0.957 (1.00) | 0.246 (0.627) | 0.0987 (0.477)
STAMBPL1 | 6 (6%) | 94 | 0.506 (0.754) | 0.935 (0.991) | 0.794 (0.921)
NES | 12 (12%) | 88 | 0.99 (1.00) | 0.124 (0.496) | 0.0564 (0.432)
MBD6 | 8 (8%) | 92 | 0.436 (0.721) | 0.0646 (0.455) | 0.212 (0.575)
SHC1 | 9 (9%) | 91 | 0.798 (0.922) | 0.351 (0.676) | 0.222 (0.582)
PEX1 | 6 (6%) | 94 | 0.204 (0.575) | 0.538 (0.771) | 0.797 (0.922)
MCPH1 | 6 (6%) | 94 | 0.972 (1.00) | 0.166 (0.559) | 0.247 (0.627)
TTLL11 | 8 (8%) | 92 | 0.383 (0.681) | 0.554 (0.775) | 0.689 (0.863)
ZNF800 | 11 (11%) | 89 | 0.837 (0.94) | 0.00367 (0.317) | 0.0212 (0.4)
HNF1A | 7 (7%) | 93 | 0.487 (0.745) | 0.112 (0.482) | 0.0973 (0.476)
PAPD4 | 6 (6%) | 94 | 0.48 (0.745) | 0.821 (0.932) | 0.605 (0.81)
NSD1 | 16 (16%) | 84 | 0.764 (0.903) | 0.0357 (0.416) | 0.0422 (0.416)
RANBP10 | 6 (6%) | 94 | 0.101 (0.477) | 0.45 (0.729) | 0.415 (0.692)
WNT1 | 4 (4%) | 96 | 0.663 (0.847) | 0.185 (0.559) | 0.157 (0.556)
IPO11 | 7 (7%) | 93 | 0.474 (0.745) | 0.0421 (0.416) | 0.0317 (0.416)
FBXL3 | 4 (4%) | 96 | 0.721 (0.884) | 1 (1.00) | 0.963 (1.00)
LNPEP | 6 (6%) | 94 | 0.0856 (0.47) | 0.541 (0.773) | 0.454 (0.729)
LINGO4 | 4 (4%) | 96 | 0.754 (0.897) | 1 (1.00) | 0.897 (0.968)
CPNE7 | 6 (6%) | 94 | 1 (1.00) | 0.174 (0.559) | 0.443 (0.725)
DPCR1 | 10 (10%) | 90 | 1 (1.00) | 0.00934 (0.395) | 0.0521 (0.428)
SMTN | 9 (9%) | 91 | 0.455 (0.729) | 0.231 (0.598) | 0.115 (0.482)
ATP2A1 | 6 (6%) | 94 | 0.302 (0.648) | 0.239 (0.617) | 0.251 (0.629)
PIGO | 7 (7%) | 93 | 0.811 (0.931) | 0.406 (0.688) | 0.248 (0.627)
RRAS2 | 5 (5%) | 95 | 1 (1.00) | 0.403 (0.688) | 0.679 (0.854)
DRD5 | 8 (8%) | 92 | 0.816 (0.932) | 0.672 (0.852) | 0.411 (0.692)
PRR25 | 5 (5%) | 95 | 0.258 (0.63) | 0.135 (0.514) | 0.229 (0.596)
PAX2 | 4 (4%) | 96 | 0.0913 (0.47) | 0.00597 (0.317) | 0.127 (0.503)
KIF24 | 4 (4%) | 96 | 0.0926 (0.47) | 0.719 (0.884) | 0.962 (1.00)
NOS3 | 7 (7%) | 93 | 0.486 (0.745) | 0.0411 (0.416) | 0.174 (0.559)
ANAPC1 | 6 (6%) | 94 | 0.055 (0.429) | 0.112 (0.482) | 0.275 (0.632)
DNHD1 | 16 (16%) | 84 | 0.301 (0.648) | 0.0181 (0.4) | 0.452 (0.729)
IL27 | 4 (4%) | 96 | 0.0019 (0.255) | 0.809 (0.93) | 0.172 (0.559)
RYR2 | 19 (19%) | 81 | 0.256 (0.629) | 0.00044 (0.255) | 0.00816 (0.395)
CHPF2 | 8 (8%) | 92 | 0.0558 (0.432) | 0.366 (0.681) | 0.0641 (0.455)
TNK2 | 9 (9%) | 91 | 0.614 (0.818) | 0.0271 (0.416) | 0.366 (0.681)
PPP2R1A | 10 (10%) | 90 | 0.834 (0.94) | 1 (1.00) | 0.679 (0.854)
KBTBD10 | 6 (6%) | 94 | 0.454 (0.729) | 0.539 (0.771) | 0.248 (0.627)
ERMP1 | 5 (5%) | 95 | 0.832 (0.94) | 0.267 (0.632) | 0.354 (0.676)
DAB2IP | 10 (10%) | 90 | 0.24 (0.617) | 0.35 (0.676) | 0.0731 (0.466)
BCOR | 11 (11%) | 89 | 0.836 (0.94) | 0.0119 (0.395) | 0.0422 (0.416)
C22ORF28 | 5 (5%) | 95 | 0.492 (0.746) | 0.52 (0.758) | 0.756 (0.897)
LHX1 | 8 (8%) | 92 | 0.741 (0.89) | 0.365 (0.681) | 0.262 (0.632)
USP26 | 9 (9%) | 91 | 0.452 (0.729) | 0.739 (0.889) | 0.347 (0.676)
RBM27 | 11 (11%) | 89 | 0.0851 (0.47) | 0.556 (0.776) | 0.292 (0.637)
CCDC43 | 7 (7%) | 93 | 0.639 (0.842) | 0.55 (0.774) | 0.278 (0.632)
LIN54 | 4 (4%) | 96 | 0.504 (0.754) | 0.319 (0.649) | 0.482 (0.745)
FAM8A1 | 6 (6%) | 94 | 0.315 (0.649) | 0.569 (0.782) | 0.405 (0.688)
ZDHHC8 | 6 (6%) | 94 | 0.255 (0.629) | 0.542 (0.773) | 0.413 (0.692)
PHKG2 | 4 (4%) | 96 | 0.0937 (0.47) | 0.0652 (0.455) | 0.105 (0.477)
POLE | 9 (9%) | 91 | 0.904 (0.974) | 0.0821 (0.47) | 0.515 (0.758)
TCERG1 | 9 (9%) | 91 | 0.568 (0.782) | 0.00523 (0.317) | 0.0256 (0.416)
TTLL10 | 4 (4%) | 96 | 0.0933 (0.47) | 0.354 (0.676) | 0.4 (0.688)
EBPL | 4 (4%) | 96 | 0.123 (0.494) | 0.184 (0.559) | 0.483 (0.745)
NOSTRIN | 4 (4%) | 96 | 0.755 (0.897) | 0.381 (0.681) | 0.285 (0.635)
DAZAP1 | 7 (7%) | 93 | 0.397 (0.688) | 0.168 (0.559) | 0.274 (0.632)
C6ORF10 | 3 (3%) | 97 | 0.551 (0.774) | 0.864 (0.944) | 0.367 (0.681)
C19ORF2 | 8 (8%) | 92 | 0.649 (0.843) | 0.0843 (0.47) | 0.213 (0.575)
HOXA11 | 5 (5%) | 95 | 0.958 (1.00) | 0.352 (0.676) | 0.309 (0.649)
ZRSR2 | 6 (6%) | 94 | 0.452 (0.729) | 0.176 (0.559) | 0.276 (0.632)
NR4A2 | 6 (6%) | 94 | 0.0151 (0.395) | 0.819 (0.932) | 0.368 (0.681)
COIL | 6 (6%) | 94 | 0.406 (0.688) | 0.447 (0.729) | 0.372 (0.681)
CDS1 | 5 (5%) | 95 | 0.957 (1.00) | 0.266 (0.632) | 0.297 (0.645)
MTMR9 | 4 (4%) | 96 | 0.278 (0.632) | 0.257 (0.63) | 0.79 (0.921)
LRP2BP | 5 (5%) | 95 | 0.0215 (0.4) | 0.176 (0.559) | 0.362 (0.681)
REPIN1 | 7 (7%) | 93 | 0.844 (0.944) | 0.0228 (0.4) | 0.389 (0.685)
DHX57 | 9 (9%) | 91 | 0.333 (0.665) | 0.663 (0.847) | 0.849 (0.944)
FHOD3 | 9 (9%) | 91 | 0.132 (0.51) | 0.0434 (0.416) | 0.0534 (0.428)
SLC25A24 | 5 (5%) | 95 | 0.0381 (0.416) | 0.187 (0.559) | 0.298 (0.645)
PPRC1 | 4 (4%) | 96 | 0.442 (0.725) | 0.653 (0.843) | 0.188 (0.559)
ZMYM3 | 10 (10%) | 90 | 0.256 (0.629) | 0.104 (0.477) | 0.0349 (0.416)
C1ORF114 | 7 (7%) | 93 | 0.64 (0.842) | 0.352 (0.676) | 0.193 (0.561)
TEX10 | 9 (9%) | 91 | 0.982 (1.00) | 0.0182 (0.4) | 0.019 (0.4)
WAC | 6 (6%) | 94 | 0.351 (0.676) | 0.111 (0.482) | 0.0966 (0.476)
CADPS | 10 (10%) | 90 | 0.567 (0.782) | 0.309 (0.649) | 0.288 (0.635)
FAM60A | 6 (6%) | 94 | 0.304 (0.649) | 0.934 (0.991) | 0.856 (0.944)
PSG1 | 5 (5%) | 95 | 0.958 (1.00) | 0.793 (0.921) | 0.145 (0.534)
MLH3 | 6 (6%) | 94 | 0.101 (0.477) | 0.0359 (0.416) | 0.11 (0.482)
NFASC | 10 (10%) | 90 | 0.302 (0.648) | 0.0416 (0.416) | 0.0387 (0.416)
ENTPD2 | 4 (4%) | 96 | 0.552 (0.775) | 0.652 (0.843) | 0.0876 (0.47)
SFRS2B | 3 (3%) | 97 | 0.549 (0.774) | 0.603 (0.809) | 0.55 (0.774)
XKR6 | 5 (5%) | 95 | 0.182 (0.559) | 0.104 (0.477) | 0.377 (0.681)
KIAA1267 | 10 (10%) | 90 | 0.19 (0.561) | 0.0278 (0.416) | 0.145 (0.534)
SGOL2 | 7 (7%) | 93 | 0.217 (0.575) | 0.037 (0.416) | 0.217 (0.575)
MSH6 | 8 (8%) | 92 | 0.719 (0.884) | 0.412 (0.692) | 0.185 (0.559)
TP53BP1 | 10 (10%) | 90 | 0.179 (0.559) | 0.00539 (0.317) | 0.0717 (0.466)
IFIH1 | 7 (7%) | 93 | 0.667 (0.848) | 0.102 (0.477) | 0.146 (0.534)
MRI1 | 3 (3%) | 97 | 0.37 (0.681) | 0.333 (0.665) | 0.49 (0.746)
PAPPA2 | 12 (12%) | 88 | 0.657 (0.845) | 0.0147 (0.395) | 0.0142 (0.395)
KRTAP10-1 | 3 (3%) | 97 | 1 (1.00) | 0.382 (0.681) | 0.491 (0.746)
PIK3R2 | 8 (8%) | 92 | 0.104 (0.477) | 0.945 (0.994) | 0.849 (0.944)
SDAD1 | 4 (4%) | 96 | 0.00755 (0.382) | 0.353 (0.676) | 0.403 (0.688)
GOLGA5 | 3 (3%) | 97 | 0.37 (0.681) | 0.505 (0.754) | 0.518 (0.758)
MAGI1 | 5 (5%) | 95 | 0.0843 (0.47) | 0.737 (0.889) | 0.793 (0.921)
PRUNE2 | 12 (12%) | 88 | 0.405 (0.688) | 0.677 (0.854) | 0.386 (0.685)
MXRA8 | 5 (5%) | 95 | 1 (1.00) | 1 (1.00) | 0.904 (0.974)
WDR47 | 7 (7%) | 93 | 0.567 (0.782) | 0.0937 (0.47) | 0.217 (0.575)
ANK3 | 13 (13%) | 87 | 0.314 (0.649) | 0.00573 (0.317) | 0.0246 (0.409)
MED25 | 5 (5%) | 95 | 0.591 (0.8) | 0.265 (0.632) | 0.382 (0.681)
LRCH2 | 8 (8%) | 92 | 0.312 (0.649) | 0.55 (0.774) | 0.868 (0.947)
SALL4 | 7 (7%) | 93 | 0.755 (0.897) | 0.166 (0.559) | 0.12 (0.489)
RTKN2 | 5 (5%) | 95 | 0.0781 (0.466) | 0.189 (0.559) | 0.309 (0.649)
TTC39B | 3 (3%) | 97 | 0.287 (0.635) | 0.38 (0.681) | 0.497 (0.749)
CDH24 | 4 (4%) | 96 | 0.86 (0.944) | 0.32 (0.649) | 0.573 (0.782)
PRR12 | 8 (8%) | 92 | 0.551 (0.774) | 0.151 (0.542) | 0.115 (0.482)
MSL3 | 9 (9%) | 91 | 0.719 (0.884) | 0.178 (0.559) | 0.279 (0.632)
PAX6 | 6 (6%) | 94 | 0.206 (0.575) | 0.82 (0.932) | 0.262 (0.632)
FLJ10357 | 10 (10%) | 90 | 0.763 (0.903) | 0.0135 (0.395) | 0.0382 (0.416)
USMG5 | 3 (3%) | 97 | 0.684 (0.859) | 0.00543 (0.317) | 0.52 (0.758)
TFDP1 | 6 (6%) | 94 | 0.27 (0.632) | 0.535 (0.77) | 0.473 (0.745)
WIF1 | 5 (5%) | 95 | 0.338 (0.672) | 0.918 (0.984) | 0.405 (0.688)
ATXN2L | 9 (9%) | 91 | 0.557 (0.777) | 0.0497 (0.428) | 0.0695 (0.46)
FLT3LG | 4 (4%) | 96 | 0.723 (0.884) | 0.649 (0.843) | 0.791 (0.921)
POLG | 10 (10%) | 90 | 0.461 (0.736) | 0.0174 (0.4) | 0.068 (0.455)
EIF2AK3 | 9 (9%) | 91 | 0.983 (1.00) | 0.0666 (0.455) | 0.0915 (0.47)
GLTSCR1 | 12 (12%) | 88 | 0.39 (0.685) | 0.0376 (0.416) | 0.553 (0.775)
CYTSB | 9 (9%) | 91 | 0.725 (0.885) | 0.0134 (0.395) | 0.0472 (0.417)
NAP1L5 | 4 (4%) | 96 | 0.859 (0.944) | 0.395 (0.687) | 0.835 (0.94)
DDX10 | 8 (8%) | 92 | 0.632 (0.836) | 0.352 (0.676) | 0.855 (0.944)
LIMK2 | 8 (8%) | 92 | 0.844 (0.944) | 0.549 (0.774) | 0.641 (0.842)
POLD1 | 6 (6%) | 94 | 0.871 (0.949) | 1 (1.00) | 0.55 (0.774)
SBNO1 | 9 (9%) | 91 | 0.0915 (0.47) | 0.0384 (0.416) | 0.0921 (0.47)
CACHD1 | 6 (6%) | 94 | 0.209 (0.575) | 0.11 (0.482) | 0.442 (0.725)
FAM200A | 4 (4%) | 96 | 0.203 (0.575) | 0.393 (0.687) | 0.213 (0.575)
KIAA1370 | 8 (8%) | 92 | 0.521 (0.758) | 0.0314 (0.416) | 0.136 (0.514)
C7ORF63 | 6 (6%) | 94 | 0.749 (0.895) | 0.16 (0.557) | 0.182 (0.559)
BAT3 | 7 (7%) | 93 | 0.06 (0.454) | 0.0982 (0.477) | 0.0837 (0.47)
WNK4 | 11 (11%) | 89 | 0.387 (0.685) | 0.147 (0.535) | 0.0796 (0.466)
VPRBP | 6 (6%) | 94 | 0.00322 (0.317) | 0.45 (0.729) | 0.795 (0.921)
DOCK5 | 7 (7%) | 93 | 0.377 (0.681) | 0.819 (0.932) | 0.606 (0.81)
PPM1D | 7 (7%) | 93 | 0.438 (0.722) | 0.0898 (0.47) | 0.276 (0.632)
MAPRE3 | 3 (3%) | 97 | 0.784 (0.917) | 0.505 (0.754) | 0.52 (0.758)
SHPRH | 10 (10%) | 90 | 0.815 (0.932) | 0.0293 (0.416) | 0.0167 (0.4)
KSR1 | 8 (8%) | 92 | 0.208 (0.575) | 0.909 (0.977) | 0.641 (0.842)
ZNF195 | 7 (7%) | 93 | 0.282 (0.635) | 0.0368 (0.416) | 0.32 (0.649)
CANX | 5 (5%) | 95 | 0.957 (1.00) | 0.264 (0.632) | 0.479 (0.745)
WHSC1 | 10 (10%) | 90 | 0.339 (0.673) | 0.0849 (0.47) | 0.289 (0.635)
TAOK3 | 6 (6%) | 94 | 0.405 (0.688) | 0.0532 (0.428) | 0.25 (0.628)
GIPC1 | 3 (3%) | 97 | 0.856 (0.944) | 0.862 (0.944) | 0.368 (0.681)
LOR | 4 (4%) | 96 | 0.14 (0.524) | 0.319 (0.649) | 0.479 (0.745)
SMAP1 | 6 (6%) | 94 | 0.696 (0.863) | 0.0913 (0.47) | 0.276 (0.632)
HERC6 | 5 (5%) | 95 | 0.834 (0.94) | 0.174 (0.559) | 0.353 (0.676)
KIAA0913 | 4 (4%) | 96 | 0.382 (0.681) | 0.0159 (0.395) | 0.211 (0.575)
FKBP11 | 3 (3%) | 97 | 0.288 (0.635) | 0.863 (0.944) | 0.369 (0.681)
C5ORF36 | 8 (8%) | 92 | 0.623 (0.827) | 0.0415 (0.416) | 0.113 (0.482)
FAT2 | 16 (16%) | 84 | 0.517 (0.758) | 0.0497 (0.428) | 0.0666 (0.455)
XRRA1 | 3 (3%) | 97 | 0.0778 (0.466) | 0.503 (0.754) | 0.519 (0.758)
ZNF583 | 4 (4%) | 96 | 0.82 (0.932) | 0.35 (0.676) | 0.312 (0.649)
FOXM1 | 7 (7%) | 93 | 0.602 (0.809) | 0.0225 (0.4) | 0.147 (0.535)
INF2 | 5 (5%) | 95 | 0.0769 (0.466) | 0.261 (0.632) | 0.375 (0.681)
SLC16A1 | 4 (4%) | 96 | 1 (1.00) | 0.319 (0.649) | 0.482 (0.745)
SMAD7 | 5 (5%) | 95 | 0.923 (0.984) | 0.738 (0.889) | 0.869 (0.947)
CELSR1 | 11 (11%) | 89 | 0.654 (0.843) | 0.0406 (0.416) | 0.0887 (0.47)
C14ORF43 | 4 (4%) | 96 | 1 (1.00) | 0.519 (0.758) | 0.962 (1.00)
SEC63 | 6 (6%) | 94 | 0.0431 (0.416) | 0.568 (0.782) | 0.314 (0.649)
USP47 | 6 (6%) | 94 | 0.944 (0.994) | 0.0897 (0.47) | 0.275 (0.632)
ZNF253 | 6 (6%) | 94 | 0.189 (0.559) | 0.54 (0.772) | 0.413 (0.692)
C1ORF141 | 6 (6%) | 94 | 0.256 (0.629) | 0.176 (0.559) | 0.274 (0.632)
COL5A1 | 12 (12%) | 88 | 0.517 (0.758) | 0.0232 (0.4) | 0.0973 (0.476)
RAB3IL1 | 5 (5%) | 95 | 0.589 (0.799) | 0.918 (0.984) | 0.179 (0.559)
C15ORF42 | 7 (7%) | 93 | 0.508 (0.754) | 0.316 (0.649) | 0.744 (0.891)
SPTY2D1 | 5 (5%) | 95 | 0.114 (0.482) | 0.173 (0.559) | 0.383 (0.681)
C19ORF66 | 3 (3%) | 97 | 0.589 (0.799) | 0.382 (0.681) | 0.494 (0.746)
MYO1A | 10 (10%) | 90 | 0.792 (0.921) | 0.0315 (0.416) | 0.103 (0.477)
DMXL2 | 11 (11%) | 89 | 0.352 (0.676) | 0.0156 (0.395) | 0.0284 (0.416)
ZIC5 | 7 (7%) | 93 | 0.319 (0.649) | 0.287 (0.635) | 0.317 (0.649)
DSC1 | 8 (8%) | 92 | 0.652 (0.843) | 0.171 (0.559) | 0.214 (0.575)
CCKBR | 4 (4%) | 96 | 0.551 (0.774) | 0.355 (0.676) | 0.309 (0.649)
QKI | 4 (4%) | 96 | 0.858 (0.944) | 0.351 (0.676) | 0.4 (0.688)
DLGAP3 | 6 (6%) | 94 | 0.616 (0.821) | 0.167 (0.559) | 0.279 (0.632)
ZNF626 | 9 (9%) | 91 | 0.762 (0.903) | 0.791 (0.921) | 0.805 (0.929)
MGA | 14 (14%) | 86 | 0.558 (0.778) | 0.0771 (0.466) | 0.0514 (0.428)
C3ORF23 | 5 (5%) | 95 | 0.438 (0.722) | 0.522 (0.758) | 0.752 (0.897)
ALPPL2 | 5 (5%) | 95 | 0.722 (0.884) | 0.733 (0.889) | 0.534 (0.769)
EFHC1 | 9 (9%) | 91 | 0.597 (0.804) | 0.0734 (0.466) | 0.0383 (0.416)
HNRNPA3 | 4 (4%) | 96 | 0.665 (0.847) | 0.508 (0.754) | 0.696 (0.863)
UBB | 4 (4%) | 96 | 0.755 (0.897) | 0.0213 (0.4) | 0.48 (0.745)
SNX25 | 4 (4%) | 96 | 0.86 (0.944) | 0.122 (0.494) | 0.573 (0.782)
GDF7 | 4 (4%) | 96 | 1 (1.00) | 0.722 (0.884) | 0.623 (0.827)
MFI2 | 5 (5%) | 95 | 0.105 (0.477) | 0.189 (0.559) | 0.297 (0.645)
AKT1 | 4 (4%) | 96 | 1 (1.00) | 0.38 (0.681) | 0.494 (0.746)
DENND4C | 7 (7%) | 93 | 0.937 (0.991) | 0.0586 (0.446) | 0.176 (0.559)
ACSM4 | 4 (4%) | 96 | 0.94 (0.991) | 1 (1.00) | 0.52 (0.758)
TNRC18 | 9 (9%) | 91 | 0.523 (0.759) | 0.375 (0.681) | 0.105 (0.477)
CACNA1F | 14 (14%) | 86 | 0.922 (0.984) | 0.00376 (0.317) | 0.0346 (0.416)
RASA1 | 8 (8%) | 92 | 0.136 (0.514) | 0.0463 (0.416) | 0.213 (0.575)
IRX5 | 7 (7%) | 93 | 0.0651 (0.455) | 0.197 (0.565) | 0.688 (0.863)
TBX10 | 3 (3%) | 97 | 0.855 (0.944) | 1 (1.00) | 0.653 (0.843)
PRIC285 | 14 (14%) | 86 | 0.691 (0.863) | 0.0517 (0.428) | 0.0407 (0.416)
MAX | 4 (4%) | 96 | 0.484 (0.745) | 1 (1.00) | 0.834 (0.94)
IQSEC2 | 11 (11%) | 89 | 0.925 (0.984) | 0.164 (0.559) | 0.154 (0.551)
KIAA1804 | 7 (7%) | 93 | 0.229 (0.596) | 0.406 (0.688) | 0.114 (0.482)
IPO9 | 5 (5%) | 95 | 0.924 (0.984) | 0.367 (0.681) | 0.588 (0.799)
TPP2 | 8 (8%) | 92 | 0.305 (0.649) | 0.0748 (0.466) | 0.0796 (0.466)
CDC73 | 7 (7%) | 93 | 0.485 (0.745) | 0.256 (0.629) | 0.251 (0.629)
HRASLS5 | 5 (5%) | 95 | 0.959 (1.00) | 0.162 (0.559) | 0.183 (0.559)
ARID4B | 6 (6%) | 94 | 0.56 (0.779) | 0.74 (0.89) | 0.452 (0.729)
SLC2A5 | 5 (5%) | 95 | 0.833 (0.94) | 0.114 (0.482) | 0.473 (0.745)
TUBB4 | 6 (6%) | 94 | 0.768 (0.907) | 0.0907 (0.47) | 0.412 (0.692)
ARID3B | 6 (6%) | 94 | 0.0788 (0.466) | 0.345 (0.676) | 0.369 (0.681)
AADACL3 | 4 (4%) | 96 | 0.246 (0.627) | 0.352 (0.676) | 0.309 (0.649)
TXNDC11 | 6 (6%) | 94 | 0.454 (0.729) | 0.0523 (0.428) | 0.252 (0.629)
TULP4 | 7 (7%) | 93 | 0.197 (0.565) | 0.132 (0.509) | 0.114 (0.482)
CALB1 | 5 (5%) | 95 | 0.642 (0.842) | 0.738 (0.889) | 0.638 (0.842)
OXER1 | 3 (3%) | 97 | 0.734 (0.889) | 0.282 (0.635) | 0.697 (0.863)
BCLAF1 | 9 (9%) | 91 | 0.782 (0.917) | 0.363 (0.681) | 0.524 (0.759)
IDH3A | 4 (4%) | 96 | 0.82 (0.932) | 0.319 (0.649) | 0.48 (0.745)
SYNM | 3 (3%) | 97 | 1 (1.00) | 0.504 (0.754) | 0.521 (0.758)
C20ORF194 | 4 (4%) | 96 | 0.663 (0.847) | 1 (1.00) | 0.674 (0.852)
FRG1 | 7 (7%) | 93 | 0.979 (1.00) | 0.109 (0.482) | 0.209 (0.575)
DOCK9 | 8 (8%) | 92 | 0.321 (0.649) | 0.411 (0.692) | 0.261 (0.632)
LMOD2 | 6 (6%) | 94 | 0.642 (0.842) | 0.365 (0.681) | 0.904 (0.974)
IGF2R | 10 (10%) | 90 | 0.601 (0.809) | 0.131 (0.509) | 0.14 (0.524)
POTEE | 5 (5%) | 95 | 0.169 (0.559) | 0.517 (0.758) | 0.963 (1.00)
N4BP2 | 11 (11%) | 89 | 0.138 (0.521) | 0.406 (0.688) | 0.262 (0.632)
RUFY2 | 5 (5%) | 95 | 0.892 (0.965) | 0.0469 (0.417) | 0.352 (0.676)
UBQLN2 | 6 (6%) | 94 | 0.348 (0.676) | 0.104 (0.477) | 0.193 (0.561)
PIGB | 6 (6%) | 94 | 0.694 (0.863) | 0.177 (0.559) | 0.247 (0.627)
TSPAN10 | 3 (3%) | 97 | 0.783 (0.917) | 1 (1.00) | 0.821 (0.932)
SFRS8 | 6 (6%) | 94 | 0.392 (0.687) | 0.45 (0.729) | 0.855 (0.944)
TSTD2 | 6 (6%) | 94 | 0.303 (0.649) | 0.0898 (0.47) | 0.194 (0.561)
WDR5 | 4 (4%) | 96 | 0.131 (0.509) | 0.507 (0.754) | 0.52 (0.758)
LPIN1 | 5 (5%) | 95 | 0.0856 (0.47) | 0.182 (0.559) | 0.158 (0.556)
OR2A4 | 3 (3%) | 97 | 1 (1.00) | 0.286 (0.635) | 0.696 (0.863)
RAPGEF4 | 9 (9%) | 91 | 0.256 (0.629) | 0.0302 (0.416) | 0.214 (0.575)
KCNA4 | 9 (9%) | 91 | 0.647 (0.843) | 0.361 (0.681) | 0.326 (0.656)
LYSMD1 | 3 (3%) | 97 | 1 (1.00) | 0.384 (0.681) | 0.693 (0.863)
MYH4 | 7 (7%) | 93 | 0.118 (0.486) | 0.548 (0.774) | 0.318 (0.649)
SEMA6C | 6 (6%) | 94 | 1 (1.00) | 0.178 (0.559) | 0.248 (0.627)
LIMCH1 | 8 (8%) | 92 | 0.93 (0.987) | 0.55 (0.774) | 0.691 (0.863)
CTSA | 4 (4%) | 96 | 0.0641 (0.455) | 0.0543 (0.429) | 0.0371 (0.416)
MAP3K4 | 13 (13%) | 87 | 0.92 (0.984) | 0.0438 (0.416) | 0.0377 (0.416)
SGK1 | 4 (4%) | 96 | 0.664 (0.847) | 0.32 (0.649) | 0.389 (0.685)
NFE2L1 | 3 (3%) | 97 | 0.0788 (0.466) | 0.861 (0.944) | 0.186 (0.559)
WASF3 | 7 (7%) | 93 | 0.119 (0.489) | 0.0899 (0.47) | 0.0375 (0.416)
ARNTL | 5 (5%) | 95 | 1 (1.00) | 0.0462 (0.416) | 0.533 (0.769)
EDC4 | 4 (4%) | 96 | 0.279 (0.632) | 0.517 (0.758) | 0.146 (0.534)
TBC1D22A | 5 (5%) | 95 | 0.0796 (0.466) | 0.736 (0.889) | 0.453 (0.729)
ALPK1 | 8 (8%) | 92 | 0.0232 (0.4) | 0.0106 (0.395) | 0.124 (0.496)
SYTL2 | 5 (5%) | 95 | 0.275 (0.632) | 0.266 (0.632) | 0.355 (0.676)
OAT | 3 (3%) | 97 | 0.0439 (0.416) | 0.0548 (0.429) | 0.0612 (0.454)
HSP90B1 | 7 (7%) | 93 | 0.743 (0.891) | 0.0607 (0.454) | 0.159 (0.557)
PTCH1 | 9 (9%) | 91 | 0.925 (0.984) | 0.0227 (0.4) | 0.069 (0.459)
SULT1E1 | 3 (3%) | 97 | 0.21 (0.575) | 0.285 (0.635) | 0.649 (0.843)
UPF3A | 5 (5%) | 95 | 0.209 (0.575) | 0.103 (0.477) | 0.127 (0.503)
DNAH8 | 12 (12%) | 88 | 0.221 (0.582) | 0.00197 (0.255) | 0.046 (0.416)
SYCP2 | 12 (12%) | 88 | 0.754 (0.897) | 0.0101 (0.395) | 0.0156 (0.395)
ATG5 | 3 (3%) | 97 | 0.287 (0.635) | 0.603 (0.809) | 0.654 (0.843)
RTN2 | 6 (6%) | 94 | 0.56 (0.779) | 0.0563 (0.432) | 0.373 (0.681)
AP2A2 | 3 (3%) | 97 | 0.0143 (0.395) | 0.0235 (0.4) | 0.211 (0.575)
ECT2 | 3 (3%) | 97 | 1 (1.00) | 0.383 (0.681) | 0.654 (0.843)
ZNF174 | 3 (3%) | 97 | 0.786 (0.918) | 0.861 (0.944) | 0.581 (0.789)
JAM3 | 6 (6%) | 94 | 0.67 (0.851) | 0.167 (0.559) | 0.275 (0.632)
EEA1 | 9 (9%) | 91 | 0.663 (0.847) | 0.474 (0.745) | 0.422 (0.703)
RTN3 | 9 (9%) | 91 | 0.216 (0.575) | 0.0132 (0.395) | 0.134 (0.512)
ZBTB7B | 4 (4%) | 96 | 0.16 (0.557) | 0.38 (0.681) | 0.493 (0.746)
ZC3H18 | 7 (7%) | 93 | 0.57 (0.782) | 0.805 (0.929) | 0.213 (0.575)
FAHD2B | 3 (3%) | 97 | 1 (1.00) |  |
SETD7 | 3 (3%) | 97 | 0.548 (0.774) | 0.504 (0.754) | 0.695 (0.863)
ZNF510 | 4 (4%) | 96 | 0.224 (0.585) | 0.318 (0.649) | 0.482 (0.745)
KIAA0408 | 8 (8%) | 92 | 0.663 (0.847) | 0.407 (0.688) | 0.374 (0.681)
PRR5L | 3 (3%) | 97 | 0.286 (0.635) | 1 (1.00) | 1 (1.00)
DST | 14 (14%) | 86 | 0.948 (0.996) | 0.045 (0.416) | 0.0503 (0.428)
NPY | 3 (3%) | 97 | 0.372 (0.681) | 0.863 (0.944) | 0.922 (0.984)
VASP | 4 (4%) | 96 | 0.939 (0.991) | 1 (1.00) | 0.656 (0.843)
COL5A3 | 5 (5%) | 95 | 0.0658 (0.455) | 0.173 (0.559) | 0.458 (0.732)
KCNQ3 | 10 (10%) | 90 | 0.909 (0.977) | 0.0723 (0.466) | 0.376 (0.681)
PLXNA1 | 11 (11%) | 89 | 0.281 (0.635) | 0.0629 (0.455) | 0.0949 (0.473)
ZNF395 | 3 (3%) | 97 | 0.855 (0.944) | 0.332 (0.665) | 0.209 (0.575)
PLA2G4C | 6 (6%) | 94 | 0.0965 (0.476) | 0.0911 (0.47) | 0.414 (0.692)
RBM6 | 10 (10%) | 90 | 0.696 (0.863) | 0.231 (0.598) | 0.169 (0.559)
COL18A1 | 11 (11%) | 89 | 0.222 (0.582) | 0.673 (0.852) | 0.368 (0.681)
ERBB3 | 7 (7%) | 93 | 0.187 (0.559) | 0.198 (0.566) | 0.467 (0.743)
PRDM2 | 13 (13%) | 87 | 0.154 (0.551) | 0.502 (0.754) | 0.204 (0.575)
C7ORF50 | 3 (3%) | 97 | 1 (1.00) | 0.282 (0.635) | 0.651 (0.843)
ARFGAP2 | 3 (3%) | 97 | 1 (1.00) | 1 (1.00) | 0.651 (0.843)
FAM81B | 6 (6%) | 94 | 0.85 (0.944) | 0.0909 (0.47) | 0.411 (0.692)
LIN37 | 3 (3%) | 97 | 0.784 (0.917) | 0.333 (0.665) | 0.212 (0.575)
SPRYD5 | 7 (7%) | 93 | 0.109 (0.482) | 0.35 (0.676) | 0.319 (0.649)
INHBA | 3 (3%) | 97 | 0.286 (0.635) | 0.508 (0.754) | 0.366 (0.681)
SOX8 | 5 (5%) | 95 | 1 (1.00) | 0.266 (0.632) | 0.356 (0.677)
WDR60 | 9 (9%) | 91 | 0.424 (0.706) | 0.00956 (0.395) | 0.0199 (0.4)
TCP10L | 4 (4%) | 96 | 0.484 (0.745) | 0.185 (0.559) | 0.479 (0.745)
MGAT4C | 5 (5%) | 95 | 0.892 (0.965) | 0.189 (0.559) | 0.181 (0.559)
ATP6V1C1 | 4 (4%) | 96 | 0.724 (0.885) | 0.516 (0.758) | 0.674 (0.852)
MNT | 6 (6%) | 94 | 0.196 (0.565) | 0.346 (0.676) | 0.467 (0.743)
PLXNB1 | 8 (8%) | 92 | 0.947 (0.995) | 0.0157 (0.395) | 0.101 (0.477)
STIM2 | 6 (6%) | 94 | 0.482 (0.745) | 0.266 (0.632) | 0.456 (0.729)
CYB5R4 | 4 (4%) | 96 | 0.819 (0.932) | 1 (1.00) | 0.392 (0.687)
SIAH2 | 3 (3%) | 97 | 0.161 (0.559) | 0.865 (0.945) | 0.26 (0.632)
NUP210L | 11 (11%) | 89 | 0.858 (0.944) | 0.0415 (0.416) | 0.039 (0.416)
ZNF609 | 5 (5%) | 95 | 0.684 (0.859) | 0.112 (0.482) | 0.148 (0.535)

'PTEN MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0218 (Fisher's exact test), Q value = 0.4

Table S1. Gene #1: 'PTEN MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PTEN MUTATED | 19 | 19 | 10 | 11 | 14
PTEN WILD-TYPE | 9 | 1 | 1 | 9 | 7

Figure S1. Get High-res Image Gene #1: 'PTEN MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

'PTEN MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0673 (Fisher's exact test), Q value = 0.45

Table S2. Gene #1: 'PTEN MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PTEN MUTATED | 30 | 24 | 8 | 9
PTEN WILD-TYPE | 5 | 9 | 8 | 3

'PTEN MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.00582 (Fisher's exact test), Q value = 0.32

Table S3. Gene #1: 'PTEN MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PTEN MUTATED | 28 | 3 | 8 | 5 | 4 | 14 | 9
PTEN WILD-TYPE | 6 | 8 | 1 | 2 | 2 | 6 | 0

Figure S2. Get High-res Image Gene #1: 'PTEN MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'ARID1A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.837 (Fisher's exact test), Q value = 0.94

Table S4. Gene #2: 'ARID1A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ARID1A MUTATED | 13 | 8 | 5 | 6 | 8
ARID1A WILD-TYPE | 15 | 12 | 6 | 14 | 13

'ARID1A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00396 (Fisher's exact test), Q value = 0.32

Table S5. Gene #2: 'ARID1A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ARID1A MUTATED | 21 | 6 | 6 | 6
ARID1A WILD-TYPE | 14 | 27 | 10 | 6

Figure S3. Get High-res Image Gene #2: 'ARID1A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'ARID1A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 4e-04 (Fisher's exact test), Q value = 0.25

Table S6. Gene #2: 'ARID1A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ARID1A MUTATED | 24 | 1 | 2 | 3 | 3 | 4 | 2
ARID1A WILD-TYPE | 10 | 10 | 7 | 4 | 3 | 16 | 7

Figure S4. Get High-res Image Gene #2: 'ARID1A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'KRAS MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.376 (Fisher's exact test), Q value = 0.68

Table S7. Gene #3: 'KRAS MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KRAS MUTATED | 7 | 10 | 4 | 6 | 5
KRAS WILD-TYPE | 21 | 10 | 7 | 14 | 16

'KRAS MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.727 (Fisher's exact test), Q value = 0.88

Table S8. Gene #3: 'KRAS MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KRAS MUTATED | 10 | 12 | 4 | 5
KRAS WILD-TYPE | 25 | 21 | 12 | 7

'KRAS MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.432 (Fisher's exact test), Q value = 0.72

Table S9. Gene #3: 'KRAS MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KRAS MUTATED | 12 | 2 | 1 | 2 | 3 | 6 | 5
KRAS WILD-TYPE | 22 | 9 | 8 | 5 | 3 | 14 | 4

'PIK3R1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.188 (Fisher's exact test), Q value = 0.56

Table S10. Gene #4: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PIK3R1 MUTATED | 6 | 4 | 2 | 10 | 7
PIK3R1 WILD-TYPE | 22 | 16 | 9 | 10 | 14

'PIK3R1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.181 (Fisher's exact test), Q value = 0.56

Table S11. Gene #4: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PIK3R1 MUTATED | 14 | 6 | 4 | 5
PIK3R1 WILD-TYPE | 21 | 27 | 12 | 7

'PIK3R1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.14 (Fisher's exact test), Q value = 0.52

Table S12. Gene #4: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PIK3R1 MUTATED | 12 | 2 | 5 | 2 | 3 | 2 | 3
PIK3R1 WILD-TYPE | 22 | 9 | 4 | 5 | 3 | 18 | 6

'RPL22 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.78 (Fisher's exact test), Q value = 0.92

Table S13. Gene #5: 'RPL22 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RPL22 MUTATED | 6 | 2 | 3 | 4 | 4
RPL22 WILD-TYPE | 22 | 18 | 8 | 16 | 17

'RPL22 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0131 (Fisher's exact test), Q value = 0.39

Table S14. Gene #5: 'RPL22 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RPL22 MUTATED | 9 | 1 | 4 | 4
RPL22 WILD-TYPE | 26 | 32 | 12 | 8

Figure S5. Get High-res Image Gene #5: 'RPL22 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'RPL22 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.00089 (Fisher's exact test), Q value = 0.25

Table S15. Gene #5: 'RPL22 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RPL22 MUTATED | 11 | 0 | 0 | 3 | 3 | 0 | 1
RPL22 WILD-TYPE | 23 | 11 | 9 | 4 | 3 | 20 | 8

Figure S6. Get High-res Image Gene #5: 'RPL22 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'LMAN1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.573 (Fisher's exact test), Q value = 0.78

Table S16. Gene #6: 'LMAN1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LMAN1 MUTATED | 5 | 4 | 0 | 3 | 5
LMAN1 WILD-TYPE | 23 | 16 | 11 | 17 | 16

'LMAN1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0812 (Fisher's exact test), Q value = 0.47

Table S17. Gene #6: 'LMAN1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LMAN1 MUTATED | 7 | 2 | 4 | 4
LMAN1 WILD-TYPE | 28 | 31 | 12 | 8

'LMAN1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0159 (Fisher's exact test), Q value = 0.39

Table S18. Gene #6: 'LMAN1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LMAN1 MUTATED | 10 | 0 | 0 | 2 | 3 | 1 | 1
LMAN1 WILD-TYPE | 24 | 11 | 9 | 5 | 3 | 19 | 8

Figure S7. Get High-res Image Gene #6: 'LMAN1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'CTCF MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.694 (Fisher's exact test), Q value = 0.86

Table S19. Gene #7: 'CTCF MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CTCF MUTATED | 7 | 5 | 4 | 4 | 3
CTCF WILD-TYPE | 21 | 15 | 7 | 16 | 18

'CTCF MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.594 (Fisher's exact test), Q value = 0.8

Table S20. Gene #7: 'CTCF MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CTCF MUTATED | 10 | 5 | 4 | 3
CTCF WILD-TYPE | 25 | 28 | 12 | 9

'CTCF MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.109 (Fisher's exact test), Q value = 0.48

Table S21. Gene #7: 'CTCF MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CTCF MUTATED | 12 | 1 | 0 | 3 | 2 | 3 | 1
CTCF WILD-TYPE | 22 | 10 | 9 | 4 | 4 | 17 | 8

'TP53 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.216 (Fisher's exact test), Q value = 0.58

Table S22. Gene #8: 'TP53 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TP53 MUTATED | 10 | 2 | 1 | 6 | 5
TP53 WILD-TYPE | 18 | 18 | 10 | 14 | 16

'TP53 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0409 (Fisher's exact test), Q value = 0.42

Table S23. Gene #8: 'TP53 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TP53 MUTATED | 6 | 6 | 8 | 1
TP53 WILD-TYPE | 29 | 27 | 8 | 11

Figure S8. Get High-res Image Gene #8: 'TP53 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'TP53 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0412 (Fisher's exact test), Q value = 0.42

Table S24. Gene #8: 'TP53 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TP53 MUTATED | 6 | 7 | 2 | 2 | 0 | 3 | 1
TP53 WILD-TYPE | 28 | 4 | 7 | 5 | 6 | 17 | 8

Figure S9. Get High-res Image Gene #8: 'TP53 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'SRPR MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.626 (Fisher's exact test), Q value = 0.83

Table S25. Gene #9: 'SRPR MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SRPR MUTATED | 3 | 4 | 3 | 2 | 4
SRPR WILD-TYPE | 25 | 16 | 8 | 18 | 17

'SRPR MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0487 (Fisher's exact test), Q value = 0.43

Table S26. Gene #9: 'SRPR MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SRPR MUTATED | 6 | 2 | 6 | 2
SRPR WILD-TYPE | 29 | 31 | 10 | 10

Figure S10. Get High-res Image Gene #9: 'SRPR MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'SRPR MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0173 (Fisher's exact test), Q value = 0.4

Table S27. Gene #9: 'SRPR MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SRPR MUTATED | 10 | 1 | 0 | 3 | 1 | 0 | 1
SRPR WILD-TYPE | 24 | 10 | 9 | 4 | 5 | 20 | 8

Figure S11. Get High-res Image Gene #9: 'SRPR MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'INPPL1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.769 (Fisher's exact test), Q value = 0.91

Table S28. Gene #10: 'INPPL1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
INPPL1 MUTATED | 6 | 5 | 1 | 6 | 4
INPPL1 WILD-TYPE | 22 | 15 | 10 | 14 | 17

'INPPL1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.182 (Fisher's exact test), Q value = 0.56

Table S29. Gene #10: 'INPPL1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
INPPL1 MUTATED | 10 | 3 | 4 | 3
INPPL1 WILD-TYPE | 25 | 30 | 12 | 9

'INPPL1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.112 (Fisher's exact test), Q value = 0.48

Table S30. Gene #10: 'INPPL1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
INPPL1 MUTATED | 12 | 0 | 1 | 1 | 2 | 2 | 2
INPPL1 WILD-TYPE | 22 | 11 | 8 | 6 | 4 | 18 | 7

'RNF43 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.879 (Fisher's exact test), Q value = 0.96

Table S31. Gene #11: 'RNF43 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RNF43 MUTATED | 5 | 2 | 2 | 3 | 2
RNF43 WILD-TYPE | 23 | 18 | 9 | 17 | 19

'RNF43 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0529 (Fisher's exact test), Q value = 0.43

Table S32. Gene #11: 'RNF43 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RNF43 MUTATED | 6 | 1 | 4 | 3
RNF43 WILD-TYPE | 29 | 32 | 12 | 9

'RNF43 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0437 (Fisher's exact test), Q value = 0.42

Table S33. Gene #11: 'RNF43 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RNF43 MUTATED | 7 | 0 | 1 | 2 | 3 | 1 | 0
RNF43 WILD-TYPE | 27 | 11 | 8 | 5 | 3 | 19 | 9

Figure S12. Get High-res Image Gene #11: 'RNF43 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'JAK1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.819 (Fisher's exact test), Q value = 0.93

Table S34. Gene #12: 'JAK1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
JAK1 MUTATED | 5 | 4 | 2 | 2 | 2
JAK1 WILD-TYPE | 23 | 16 | 9 | 18 | 19

'JAK1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00169 (Fisher's exact test), Q value = 0.25

Table S35. Gene #12: 'JAK1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
JAK1 MUTATED | 9 | 0 | 5 | 1
JAK1 WILD-TYPE | 26 | 33 | 11 | 11

Figure S13. Get High-res Image Gene #12: 'JAK1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'JAK1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.006 (Fisher's exact test), Q value = 0.32

Table S36. Gene #12: 'JAK1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
JAK1 MUTATED | 10 | 0 | 1 | 3 | 1 | 0 | 0
JAK1 WILD-TYPE | 24 | 11 | 8 | 4 | 5 | 20 | 9

Figure S14. Get High-res Image Gene #12: 'JAK1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'PHF2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.821 (Fisher's exact test), Q value = 0.93

Table S37. Gene #13: 'PHF2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PHF2 MUTATED | 3 | 4 | 1 | 4 | 4
PHF2 WILD-TYPE | 25 | 16 | 10 | 16 | 17

'PHF2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.394 (Fisher's exact test), Q value = 0.69

Table S38. Gene #13: 'PHF2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PHF2 MUTATED | 6 | 3 | 4 | 3
PHF2 WILD-TYPE | 29 | 30 | 12 | 9

'PHF2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0952 (Fisher's exact test), Q value = 0.47

Table S39. Gene #13: 'PHF2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PHF2 MUTATED | 6 | 1 | 0 | 3 | 3 | 2 | 1
PHF2 WILD-TYPE | 28 | 10 | 9 | 4 | 3 | 18 | 8

'FBXW7 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.775 (Fisher's exact test), Q value = 0.91

Table S40. Gene #14: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FBXW7 MUTATED | 4 | 3 | 2 | 4 | 6
FBXW7 WILD-TYPE | 24 | 17 | 9 | 16 | 15

'FBXW7 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S41. Gene #14: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FBXW7 MUTATED | 7 | 6 | 3 | 2
FBXW7 WILD-TYPE | 28 | 27 | 13 | 10

'FBXW7 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.486 (Fisher's exact test), Q value = 0.75

Table S42. Gene #14: 'FBXW7 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FBXW7 MUTATED | 8 | 2 | 1 | 3 | 0 | 2 | 2
FBXW7 WILD-TYPE | 26 | 9 | 8 | 4 | 6 | 18 | 7

'ACVR2A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.564 (Fisher's exact test), Q value = 0.78

Table S43. Gene #15: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ACVR2A MUTATED | 2 | 2 | 0 | 3 | 4
ACVR2A WILD-TYPE | 26 | 18 | 11 | 17 | 17

'ACVR2A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0157 (Fisher's exact test), Q value = 0.39

Table S44. Gene #15: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ACVR2A MUTATED | 8 | 0 | 2 | 1
ACVR2A WILD-TYPE | 27 | 33 | 14 | 11

Figure S15. Get High-res Image Gene #15: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'ACVR2A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0273 (Fisher's exact test), Q value = 0.42

Table S45. Gene #15: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ACVR2A MUTATED | 9 | 0 | 0 | 1 | 1 | 0 | 0
ACVR2A WILD-TYPE | 25 | 11 | 9 | 6 | 5 | 20 | 9

Figure S16. Get High-res Image Gene #15: 'ACVR2A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'ADNP MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.647 (Fisher's exact test), Q value = 0.84

Table S46. Gene #16: 'ADNP MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ADNP MUTATED | 1 | 2 | 1 | 3 | 2
ADNP WILD-TYPE | 27 | 18 | 10 | 17 | 19

'ADNP MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.947 (Fisher's exact test), Q value = 1

Table S47. Gene #16: 'ADNP MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ADNP MUTATED | 4 | 2 | 1 | 1
ADNP WILD-TYPE | 31 | 31 | 15 | 11

'ADNP MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.416 (Fisher's exact test), Q value = 0.69

Table S48. Gene #16: 'ADNP MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ADNP MUTATED | 3 | 0 | 0 | 1 | 1 | 1 | 2
ADNP WILD-TYPE | 31 | 11 | 9 | 6 | 5 | 19 | 7

'ZFP36L2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.265 (Fisher's exact test), Q value = 0.63

Table S49. Gene #17: 'ZFP36L2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZFP36L2 MUTATED | 2 | 2 | 0 | 1 | 5
ZFP36L2 WILD-TYPE | 26 | 18 | 11 | 19 | 16

'ZFP36L2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.117 (Fisher's exact test), Q value = 0.48

Table S50. Gene #17: 'ZFP36L2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZFP36L2 MUTATED | 2 | 2 | 3 | 3
ZFP36L2 WILD-TYPE | 33 | 31 | 13 | 9

'ZFP36L2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.254 (Fisher's exact test), Q value = 0.63

Table S51. Gene #17: 'ZFP36L2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZFP36L2 MUTATED | 4 | 1 | 1 | 1 | 2 | 0 | 1
ZFP36L2 WILD-TYPE | 30 | 10 | 8 | 6 | 4 | 20 | 8

'SEC31A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.94 (Fisher's exact test), Q value = 0.99

Table S52. Gene #18: 'SEC31A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SEC31A MUTATED | 5 | 3 | 3 | 4 | 4
SEC31A WILD-TYPE | 23 | 17 | 8 | 16 | 17

'SEC31A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.014 (Fisher's exact test), Q value = 0.39

Table S53. Gene #18: 'SEC31A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SEC31A MUTATED | 9 | 1 | 5 | 3
SEC31A WILD-TYPE | 26 | 32 | 11 | 9

Figure S17. Get High-res Image Gene #18: 'SEC31A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'SEC31A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.00097 (Fisher's exact test), Q value = 0.25

Table S54. Gene #18: 'SEC31A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SEC31A MUTATED | 10 | 0 | 0 | 4 | 3 | 1 | 0
SEC31A WILD-TYPE | 24 | 11 | 9 | 3 | 3 | 19 | 9

Figure S18. Get High-res Image Gene #18: 'SEC31A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'CMTM1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.708 (Fisher's exact test), Q value = 0.87

Table S55. Gene #19: 'CMTM1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CMTM1 MUTATED | 4 | 1 | 0 | 1 | 1
CMTM1 WILD-TYPE | 24 | 19 | 11 | 19 | 20

'CMTM1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.549 (Fisher's exact test), Q value = 0.77

Table S56. Gene #19: 'CMTM1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CMTM1 MUTATED | 3 | 1 | 2 | 1
CMTM1 WILD-TYPE | 32 | 32 | 14 | 11

'CMTM1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.317 (Fisher's exact test), Q value = 0.65

Table S57. Gene #19: 'CMTM1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CMTM1 MUTATED | 5 | 0 | 0 | 1 | 0 | 0 | 1
CMTM1 WILD-TYPE | 29 | 11 | 9 | 6 | 6 | 20 | 8

'TEAD2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.748 (Fisher's exact test), Q value = 0.89

Table S58. Gene #20: 'TEAD2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TEAD2 MUTATED | 2 | 1 | 2 | 1 | 2
TEAD2 WILD-TYPE | 26 | 19 | 9 | 19 | 19

'TEAD2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.843 (Fisher's exact test), Q value = 0.94

Table S59. Gene #20: 'TEAD2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TEAD2 MUTATED | 2 | 2 | 2 | 1
TEAD2 WILD-TYPE | 33 | 31 | 14 | 11

'TEAD2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0521 (Fisher's exact test), Q value = 0.43

Table S60. Gene #20: 'TEAD2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TEAD2 MUTATED | 2 | 0 | 0 | 2 | 1 | 0 | 2
TEAD2 WILD-TYPE | 32 | 11 | 9 | 5 | 5 | 20 | 7

'NCOR2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.701 (Fisher's exact test), Q value = 0.87

Table S61. Gene #21: 'NCOR2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NCOR2 MUTATED | 5 | 4 | 0 | 3 | 3
NCOR2 WILD-TYPE | 23 | 16 | 11 | 17 | 18

'NCOR2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00136 (Fisher's exact test), Q value = 0.25

Table S62. Gene #21: 'NCOR2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NCOR2 MUTATED | 12 | 1 | 2 | 0
NCOR2 WILD-TYPE | 23 | 32 | 14 | 12

Figure S19. Get High-res Image Gene #21: 'NCOR2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'NCOR2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.133 (Fisher's exact test), Q value = 0.51

Table S63. Gene #21: 'NCOR2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NCOR2 MUTATED | 9 | 2 | 2 | 1 | 0 | 0 | 1
NCOR2 WILD-TYPE | 25 | 9 | 7 | 6 | 6 | 20 | 8

'WDTC1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.276 (Fisher's exact test), Q value = 0.63

Table S64. Gene #22: 'WDTC1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
WDTC1 MUTATED | 5 | 2 | 1 | 0 | 1
WDTC1 WILD-TYPE | 23 | 18 | 10 | 20 | 20

'WDTC1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0464 (Fisher's exact test), Q value = 0.42

Table S65. Gene #22: 'WDTC1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
WDTC1 MUTATED | 5 | 0 | 3 | 1
WDTC1 WILD-TYPE | 30 | 33 | 13 | 11

Figure S20. Get High-res Image Gene #22: 'WDTC1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'WDTC1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.191 (Fisher's exact test), Q value = 0.56

Table S66. Gene #22: 'WDTC1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
WDTC1 MUTATED | 6 | 0 | 0 | 1 | 1 | 0 | 1
WDTC1 WILD-TYPE | 28 | 11 | 9 | 6 | 5 | 20 | 8

'NDUFC2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.807 (Fisher's exact test), Q value = 0.93

Table S67. Gene #23: 'NDUFC2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NDUFC2 MUTATED | 1 | 2 | 0 | 1 | 2
NDUFC2 WILD-TYPE | 27 | 18 | 11 | 19 | 19

'NDUFC2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.12 (Fisher's exact test), Q value = 0.49

Table S68. Gene #23: 'NDUFC2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NDUFC2 MUTATED | 1 | 1 | 3 | 1
NDUFC2 WILD-TYPE | 34 | 32 | 13 | 11

'NDUFC2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.606 (Fisher's exact test), Q value = 0.81

Table S69. Gene #23: 'NDUFC2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NDUFC2 MUTATED | 3 | 0 | 0 | 1 | 1 | 1 | 0
NDUFC2 WILD-TYPE | 31 | 11 | 9 | 6 | 5 | 19 | 9

'ZBTB20 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.925 (Fisher's exact test), Q value = 0.98

Table S70. Gene #24: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZBTB20 MUTATED | 4 | 1 | 1 | 2 | 3
ZBTB20 WILD-TYPE | 24 | 19 | 10 | 18 | 18

'ZBTB20 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.185 (Fisher's exact test), Q value = 0.56

Table S71. Gene #24: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZBTB20 MUTATED | 5 | 1 | 3 | 2
ZBTB20 WILD-TYPE | 30 | 32 | 13 | 10

'ZBTB20 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.131 (Fisher's exact test), Q value = 0.51

Table S72. Gene #24: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZBTB20 MUTATED | 7 | 0 | 0 | 1 | 2 | 1 | 0
ZBTB20 WILD-TYPE | 27 | 11 | 9 | 6 | 4 | 19 | 9

'ARID5B MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.568 (Fisher's exact test), Q value = 0.78

Table S73. Gene #25: 'ARID5B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ARID5B MUTATED | 3 | 4 | 2 | 2 | 1
ARID5B WILD-TYPE | 25 | 16 | 9 | 18 | 20

'ARID5B MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0266 (Fisher's exact test), Q value = 0.42

Table S74. Gene #25: 'ARID5B MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ARID5B MUTATED | 9 | 3 | 0 | 0
ARID5B WILD-TYPE | 26 | 30 | 16 | 12

Figure S21. Get High-res Image Gene #25: 'ARID5B MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'ARID5B MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.169 (Fisher's exact test), Q value = 0.56

Table S75. Gene #25: 'ARID5B MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ARID5B MUTATED | 6 | 0 | 2 | 0 | 0 | 1 | 3
ARID5B WILD-TYPE | 28 | 11 | 7 | 7 | 6 | 19 | 6

'CEL MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.621 (Fisher's exact test), Q value = 0.83

Table S76. Gene #26: 'CEL MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CEL MUTATED | 4 | 1 | 2 | 1 | 3
CEL WILD-TYPE | 24 | 19 | 9 | 19 | 18

'CEL MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.291 (Fisher's exact test), Q value = 0.64

Table S77. Gene #26: 'CEL MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CEL MUTATED | 4 | 2 | 4 | 1
CEL WILD-TYPE | 31 | 31 | 12 | 11

'CEL MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.292 (Fisher's exact test), Q value = 0.64

Table S78. Gene #26: 'CEL MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CEL MUTATED | 6 | 0 | 0 | 2 | 1 | 1 | 1
CEL WILD-TYPE | 28 | 11 | 9 | 5 | 5 | 19 | 8

'RNF145 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.745 (Fisher's exact test), Q value = 0.89

Table S79. Gene #27: 'RNF145 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RNF145 MUTATED | 2 | 1 | 2 | 1 | 2
RNF145 WILD-TYPE | 26 | 19 | 9 | 19 | 19

'RNF145 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.531 (Fisher's exact test), Q value = 0.77

Table S80. Gene #27: 'RNF145 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RNF145 MUTATED | 4 | 1 | 2 | 1
RNF145 WILD-TYPE | 31 | 32 | 14 | 11

'RNF145 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.487 (Fisher's exact test), Q value = 0.75

Table S81. Gene #27: 'RNF145 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RNF145 MUTATED | 4 | 0 | 2 | 1 | 0 | 1 | 0
RNF145 WILD-TYPE | 30 | 11 | 7 | 6 | 6 | 19 | 9

'BAX MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.845 (Fisher's exact test), Q value = 0.94

Table S82. Gene #28: 'BAX MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
BAX MUTATED | 3 | 1 | 0 | 2 | 1
BAX WILD-TYPE | 25 | 19 | 11 | 18 | 20

'BAX MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0766 (Fisher's exact test), Q value = 0.47

Table S83. Gene #28: 'BAX MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
BAX MUTATED | 3 | 0 | 3 | 1
BAX WILD-TYPE | 32 | 33 | 13 | 11

'BAX MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.211 (Fisher's exact test), Q value = 0.58

Table S84. Gene #28: 'BAX MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
BAX MUTATED | 5 | 0 | 0 | 1 | 1 | 0 | 0
BAX WILD-TYPE | 29 | 11 | 9 | 6 | 5 | 20 | 9

'ARSJ MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.594 (Fisher's exact test), Q value = 0.8

Table S85. Gene #29: 'ARSJ MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ARSJ MUTATED | 3 | 0 | 0 | 1 | 2
ARSJ WILD-TYPE | 25 | 20 | 11 | 19 | 19

'ARSJ MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.105 (Fisher's exact test), Q value = 0.48

Table S86. Gene #29: 'ARSJ MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ARSJ MUTATED | 4 | 0 | 2 | 0
ARSJ WILD-TYPE | 31 | 33 | 14 | 12

'ARSJ MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.193 (Fisher's exact test), Q value = 0.56

Table S87. Gene #29: 'ARSJ MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ARSJ MUTATED | 6 | 0 | 0 | 0 | 0 | 0 | 0
ARSJ WILD-TYPE | 28 | 11 | 9 | 7 | 6 | 20 | 9

'FAHD2A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.378 (Fisher's exact test), Q value = 0.68

Table S88. Gene #30: 'FAHD2A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FAHD2A MUTATED | 2 | 2 | 1 | 0 | 0
FAHD2A WILD-TYPE | 26 | 18 | 10 | 20 | 21

'FAHD2A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.398 (Fisher's exact test), Q value = 0.69

Table S89. Gene #30: 'FAHD2A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FAHD2A MUTATED | 1 | 1 | 2 | 0
FAHD2A WILD-TYPE | 34 | 32 | 14 | 12

'FAHD2A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.389 (Fisher's exact test), Q value = 0.68

Table S90. Gene #30: 'FAHD2A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FAHD2A MUTATED | 2 | 0 | 0 | 1 | 0 | 0 | 1
FAHD2A WILD-TYPE | 32 | 11 | 9 | 6 | 6 | 20 | 8

'KIAA1919 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.268 (Fisher's exact test), Q value = 0.63

Table S91. Gene #31: 'KIAA1919 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KIAA1919 MUTATED | 2 | 3 | 2 | 0 | 1
KIAA1919 WILD-TYPE | 26 | 17 | 9 | 20 | 20

'KIAA1919 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0403 (Fisher's exact test), Q value = 0.42

Table S92. Gene #31: 'KIAA1919 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KIAA1919 MUTATED | 3 | 0 | 3 | 2
KIAA1919 WILD-TYPE | 32 | 33 | 13 | 10

Figure S22. Get High-res Image Gene #31: 'KIAA1919 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'KIAA1919 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.041 (Fisher's exact test), Q value = 0.42

Table S93. Gene #31: 'KIAA1919 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KIAA1919 MUTATED | 4 | 0 | 0 | 2 | 2 | 0 | 0
KIAA1919 WILD-TYPE | 30 | 11 | 9 | 5 | 4 | 20 | 9

Figure S23. Get High-res Image Gene #31: 'KIAA1919 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'PHTF1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.484 (Fisher's exact test), Q value = 0.75

Table S94. Gene #32: 'PHTF1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PHTF1 MUTATED | 3 | 1 | 0 | 1 | 4
PHTF1 WILD-TYPE | 25 | 19 | 11 | 19 | 17

'PHTF1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0667 (Fisher's exact test), Q value = 0.45

Table S95. Gene #32: 'PHTF1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PHTF1 MUTATED | 5 | 0 | 2 | 2
PHTF1 WILD-TYPE | 30 | 33 | 14 | 10

'PHTF1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0378 (Fisher's exact test), Q value = 0.42

Table S96. Gene #32: 'PHTF1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PHTF1 MUTATED | 5 | 0 | 0 | 2 | 2 | 0 | 0
PHTF1 WILD-TYPE | 29 | 11 | 9 | 5 | 4 | 20 | 9

Figure S24. Get High-res Image Gene #32: 'PHTF1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'ZFHX3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.32 (Fisher's exact test), Q value = 0.65

Table S97. Gene #33: 'ZFHX3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZFHX3 MUTATED | 3 | 5 | 3 | 3 | 7
ZFHX3 WILD-TYPE | 25 | 15 | 8 | 17 | 14

'ZFHX3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0192 (Fisher's exact test), Q value = 0.4

Table S98. Gene #33: 'ZFHX3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZFHX3 MUTATED | 9 | 2 | 5 | 5
ZFHX3 WILD-TYPE | 26 | 31 | 11 | 7

Figure S25. Get High-res Image Gene #33: 'ZFHX3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'ZFHX3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.00358 (Fisher's exact test), Q value = 0.32

Table S99. Gene #33: 'ZFHX3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZFHX3 MUTATED | 11 | 0 | 1 | 3 | 4 | 1 | 1
ZFHX3 WILD-TYPE | 23 | 11 | 8 | 4 | 2 | 19 | 8

Figure S26. Get High-res Image Gene #33: 'ZFHX3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'ESRP1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.122 (Fisher's exact test), Q value = 0.49

Table S100. Gene #34: 'ESRP1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ESRP1 MUTATED | 0 | 2 | 1 | 3 | 4
ESRP1 WILD-TYPE | 28 | 18 | 10 | 17 | 17

'ESRP1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.117 (Fisher's exact test), Q value = 0.48

Table S101. Gene #34: 'ESRP1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ESRP1 MUTATED | 2 | 2 | 3 | 3
ESRP1 WILD-TYPE | 33 | 31 | 13 | 9

'ESRP1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0329 (Fisher's exact test), Q value = 0.42

Table S102. Gene #34: 'ESRP1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ESRP1 MUTATED | 3 | 0 | 0 | 2 | 3 | 2 | 0
ESRP1 WILD-TYPE | 31 | 11 | 9 | 5 | 3 | 18 | 9

Figure S27. Get High-res Image Gene #34: 'ESRP1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'PROM1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.569 (Fisher's exact test), Q value = 0.78

Table S103. Gene #35: 'PROM1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PROM1 MUTATED | 4 | 1 | 2 | 1 | 1
PROM1 WILD-TYPE | 24 | 19 | 9 | 19 | 20

'PROM1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0139 (Fisher's exact test), Q value = 0.39

Table S104. Gene #35: 'PROM1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PROM1 MUTATED | 7 | 0 | 2 | 0
PROM1 WILD-TYPE | 28 | 33 | 14 | 12

Figure S28. Get High-res Image Gene #35: 'PROM1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'PROM1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0522 (Fisher's exact test), Q value = 0.43

Table S105. Gene #35: 'PROM1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PROM1 MUTATED | 8 | 0 | 0 | 1 | 0 | 0 | 0
PROM1 WILD-TYPE | 26 | 11 | 9 | 6 | 6 | 20 | 9

'SFRS15 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.936 (Fisher's exact test), Q value = 0.99

Table S106. Gene #36: 'SFRS15 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SFRS15 MUTATED | 5 | 3 | 1 | 2 | 4
SFRS15 WILD-TYPE | 23 | 17 | 10 | 18 | 17

'SFRS15 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0464 (Fisher's exact test), Q value = 0.42

Table S107. Gene #36: 'SFRS15 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SFRS15 MUTATED | 9 | 1 | 2 | 2
SFRS15 WILD-TYPE | 26 | 32 | 14 | 10

Figure S29. Get High-res Image Gene #36: 'SFRS15 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'SFRS15 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0447 (Fisher's exact test), Q value = 0.42

Table S108. Gene #36: 'SFRS15 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SFRS15 MUTATED | 10 | 0 | 1 | 1 | 1 | 0 | 1
SFRS15 WILD-TYPE | 24 | 11 | 8 | 6 | 5 | 20 | 8

Figure S30. Get High-res Image Gene #36: 'SFRS15 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'USP35 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.442 (Fisher's exact test), Q value = 0.72

Table S109. Gene #37: 'USP35 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
USP35 MUTATED | 1 | 3 | 2 | 1 | 2
USP35 WILD-TYPE | 27 | 17 | 9 | 19 | 19

'USP35 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.256 (Fisher's exact test), Q value = 0.63

Table S110. Gene #37: 'USP35 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
USP35 MUTATED | 5 | 1 | 1 | 2
USP35 WILD-TYPE | 30 | 32 | 15 | 10

'USP35 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.193 (Fisher's exact test), Q value = 0.56

Table S111. Gene #37: 'USP35 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
USP35 MUTATED | 6 | 0 | 0 | 1 | 1 | 0 | 1
USP35 WILD-TYPE | 28 | 11 | 9 | 6 | 5 | 20 | 8

'PRRG1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.849 (Fisher's exact test), Q value = 0.94

Table S112. Gene #38: 'PRRG1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PRRG1 MUTATED | 1 | 2 | 1 | 1 | 1
PRRG1 WILD-TYPE | 27 | 18 | 10 | 19 | 20

'PRRG1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.163 (Fisher's exact test), Q value = 0.56

Table S113. Gene #38: 'PRRG1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PRRG1 MUTATED | 3 | 0 | 2 | 1
PRRG1 WILD-TYPE | 32 | 33 | 14 | 11

'PRRG1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.276 (Fisher's exact test), Q value = 0.63

Table S114. Gene #38: 'PRRG1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PRRG1 MUTATED | 4 | 0 | 0 | 1 | 1 | 0 | 0
PRRG1 WILD-TYPE | 30 | 11 | 9 | 6 | 5 | 20 | 9

'CTNNB1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.727 (Fisher's exact test), Q value = 0.88

Table S115. Gene #39: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CTNNB1 MUTATED | 8 | 6 | 2 | 4 | 8
CTNNB1 WILD-TYPE | 20 | 14 | 9 | 16 | 13

'CTNNB1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0237 (Fisher's exact test), Q value = 0.4

Table S116. Gene #39: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CTNNB1 MUTATED | 15 | 7 | 1 | 5
CTNNB1 WILD-TYPE | 20 | 26 | 15 | 7

Figure S31. Get High-res Image Gene #39: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'CTNNB1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.00132 (Fisher's exact test), Q value = 0.25

Table S117. Gene #39: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CTNNB1 MUTATED | 14 | 0 | 6 | 0 | 1 | 7 | 0
CTNNB1 WILD-TYPE | 20 | 11 | 3 | 7 | 5 | 13 | 9

Figure S32. Get High-res Image Gene #39: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'HNRNPL MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.808 (Fisher's exact test), Q value = 0.93

Table S118. Gene #40: 'HNRNPL MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
HNRNPL MUTATED | 1 | 2 | 0 | 1 | 2
HNRNPL WILD-TYPE | 27 | 18 | 11 | 19 | 19

'HNRNPL MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.57 (Fisher's exact test), Q value = 0.78

Table S119. Gene #40: 'HNRNPL MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
HNRNPL MUTATED | 2 | 1 | 2 | 1
HNRNPL WILD-TYPE | 33 | 32 | 14 | 11

'HNRNPL MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.371 (Fisher's exact test), Q value = 0.68

Table S120. Gene #40: 'HNRNPL MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
HNRNPL MUTATED | 4 | 0 | 0 | 0 | 1 | 0 | 1
HNRNPL WILD-TYPE | 30 | 11 | 9 | 7 | 5 | 20 | 8

'MLL4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.709 (Fisher's exact test), Q value = 0.88

Table S121. Gene #41: 'MLL4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MLL4 MUTATED | 5 | 7 | 2 | 4 | 5
MLL4 WILD-TYPE | 23 | 13 | 9 | 16 | 16

'MLL4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0187 (Fisher's exact test), Q value = 0.4

Table S122. Gene #41: 'MLL4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MLL4 MUTATED | 12 | 2 | 5 | 3
MLL4 WILD-TYPE | 23 | 31 | 11 | 9

Figure S33. Get High-res Image Gene #41: 'MLL4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'MLL4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0658 (Fisher's exact test), Q value = 0.45

Table S123. Gene #41: 'MLL4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MLL4 MUTATED | 12 | 0 | 2 | 3 | 2 | 2 | 1
MLL4 WILD-TYPE | 22 | 11 | 7 | 4 | 4 | 18 | 8

'SNRK MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.483 (Fisher's exact test), Q value = 0.75

Table S124. Gene #42: 'SNRK MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SNRK MUTATED | 1 | 0 | 1 | 2 | 2
SNRK WILD-TYPE | 27 | 20 | 10 | 18 | 19

'SNRK MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0923 (Fisher's exact test), Q value = 0.47

Table S125. Gene #42: 'SNRK MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SNRK MUTATED | 5 | 0 | 1 | 0
SNRK WILD-TYPE | 30 | 33 | 15 | 12

'SNRK MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.197 (Fisher's exact test), Q value = 0.57

Table S126. Gene #42: 'SNRK MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SNRK MUTATED | 6 | 0 | 0 | 0 | 0 | 0 | 0
SNRK WILD-TYPE | 28 | 11 | 9 | 7 | 6 | 20 | 9

'OR6C75 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.722 (Fisher's exact test), Q value = 0.88

Table S127. Gene #43: 'OR6C75 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
OR6C75 MUTATED | 2 | 2 | 0 | 0 | 1
OR6C75 WILD-TYPE | 26 | 18 | 11 | 20 | 20

'OR6C75 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0537 (Fisher's exact test), Q value = 0.43

Table S128. Gene #43: 'OR6C75 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
OR6C75 MUTATED | 2 | 0 | 3 | 0
OR6C75 WILD-TYPE | 33 | 33 | 13 | 12

'OR6C75 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.382 (Fisher's exact test), Q value = 0.68

Table S129. Gene #43: 'OR6C75 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
OR6C75 MUTATED | 4 | 0 | 0 | 1 | 0 | 0 | 0
OR6C75 WILD-TYPE | 30 | 11 | 9 | 6 | 6 | 20 | 9

'CCDC73 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.784 (Fisher's exact test), Q value = 0.92

Table S130. Gene #44: 'CCDC73 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CCDC73 MUTATED | 4 | 3 | 2 | 1 | 2
CCDC73 WILD-TYPE | 24 | 17 | 9 | 19 | 19

'CCDC73 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0201 (Fisher's exact test), Q value = 0.4

Table S131. Gene #44: 'CCDC73 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CCDC73 MUTATED | 7 | 0 | 3 | 1
CCDC73 WILD-TYPE | 28 | 33 | 13 | 11

Figure S34. Get High-res Image Gene #44: 'CCDC73 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'CCDC73 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0422 (Fisher's exact test), Q value = 0.42

Table S132. Gene #44: 'CCDC73 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CCDC73 MUTATED | 8 | 0 | 1 | 2 | 0 | 0 | 0
CCDC73 WILD-TYPE | 26 | 11 | 8 | 5 | 6 | 20 | 9

Figure S35. Get High-res Image Gene #44: 'CCDC73 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'SLAMF1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.893 (Fisher's exact test), Q value = 0.97

Table S133. Gene #45: 'SLAMF1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SLAMF1 MUTATED | 1 | 1 | 0 | 2 | 1
SLAMF1 WILD-TYPE | 27 | 19 | 11 | 18 | 20

'SLAMF1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.335 (Fisher's exact test), Q value = 0.67

Table S134. Gene #45: 'SLAMF1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SLAMF1 MUTATED | 1 | 1 | 2 | 1
SLAMF1 WILD-TYPE | 34 | 32 | 14 | 11

'SLAMF1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.249 (Fisher's exact test), Q value = 0.63

Table S135. Gene #45: 'SLAMF1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SLAMF1 MUTATED | 2 | 0 | 0 | 1 | 1 | 0 | 1
SLAMF1 WILD-TYPE | 32 | 11 | 9 | 6 | 5 | 20 | 8

'SLC3A2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.849 (Fisher's exact test), Q value = 0.94

Table S136. Gene #46: 'SLC3A2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SLC3A2 MUTATED | 1 | 2 | 1 | 1 | 1
SLC3A2 WILD-TYPE | 27 | 18 | 10 | 19 | 20

'SLC3A2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S137. Gene #46: 'SLC3A2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SLC3A2 MUTATED | 2 | 2 | 1 | 1
SLC3A2 WILD-TYPE | 33 | 31 | 15 | 11

'SLC3A2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.14 (Fisher's exact test), Q value = 0.52

Table S138. Gene #46: 'SLC3A2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SLC3A2 MUTATED | 2 | 0 | 0 | 1 | 1 | 0 | 2
SLC3A2 WILD-TYPE | 32 | 11 | 9 | 6 | 5 | 20 | 7

'CHD3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0279 (Fisher's exact test), Q value = 0.42

Table S139. Gene #47: 'CHD3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CHD3 MUTATED | 2 | 5 | 2 | 0 | 6
CHD3 WILD-TYPE | 26 | 15 | 9 | 20 | 15

Figure S36. Get High-res Image Gene #47: 'CHD3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

'CHD3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0705 (Fisher's exact test), Q value = 0.46

Table S140. Gene #47: 'CHD3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CHD3 MUTATED | 7 | 1 | 3 | 3
CHD3 WILD-TYPE | 28 | 32 | 13 | 9

'CHD3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0745 (Fisher's exact test), Q value = 0.47

Table S141. Gene #47: 'CHD3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CHD3 MUTATED | 8 | 0 | 2 | 2 | 1 | 0 | 1
CHD3 WILD-TYPE | 26 | 11 | 7 | 5 | 5 | 20 | 8

'XPOT MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.226 (Fisher's exact test), Q value = 0.59

Table S142. Gene #48: 'XPOT MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
XPOT MUTATED | 1 | 2 | 3 | 1 | 2
XPOT WILD-TYPE | 27 | 18 | 8 | 19 | 19

'XPOT MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.13 (Fisher's exact test), Q value = 0.51

Table S143. Gene #48: 'XPOT MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
XPOT MUTATED | 4 | 1 | 1 | 3
XPOT WILD-TYPE | 31 | 32 | 15 | 9

'XPOT MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0914 (Fisher's exact test), Q value = 0.47

Table S144. Gene #48: 'XPOT MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
XPOT MUTATED | 5 | 2 | 0 | 0 | 2 | 0 | 0
XPOT WILD-TYPE | 29 | 9 | 9 | 7 | 4 | 20 | 9

'NRIP1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.3 (Fisher's exact test), Q value = 0.65

Table S145. Gene #49: 'NRIP1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NRIP1 MUTATED | 1 | 4 | 0 | 1 | 2
NRIP1 WILD-TYPE | 27 | 16 | 11 | 19 | 19

'NRIP1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.311 (Fisher's exact test), Q value = 0.65

Table S146. Gene #49: 'NRIP1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NRIP1 MUTATED | 3 | 1 | 2 | 2
NRIP1 WILD-TYPE | 32 | 32 | 14 | 10

'NRIP1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.182 (Fisher's exact test), Q value = 0.56

Table S147. Gene #49: 'NRIP1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NRIP1 MUTATED | 4 | 0 | 0 | 1 | 1 | 0 | 2
NRIP1 WILD-TYPE | 30 | 11 | 9 | 6 | 5 | 20 | 7

'MAZ MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.484 (Fisher's exact test), Q value = 0.75

Table S148. Gene #50: 'MAZ MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MAZ MUTATED | 2 | 0 | 1 | 1 | 0
MAZ WILD-TYPE | 26 | 20 | 10 | 19 | 21

'MAZ MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.183 (Fisher's exact test), Q value = 0.56

Table S149. Gene #50: 'MAZ MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MAZ MUTATED | 2 | 0 | 2 | 0
MAZ WILD-TYPE | 33 | 33 | 14 | 12

'MAZ MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.726 (Fisher's exact test), Q value = 0.88

Table S150. Gene #50: 'MAZ MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MAZ MUTATED | 3 | 1 | 0 | 0 | 0 | 0 | 0
MAZ WILD-TYPE | 31 | 10 | 9 | 7 | 6 | 20 | 9

'LCE4A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.717 (Fisher's exact test), Q value = 0.88

Table S151. Gene #51: 'LCE4A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LCE4A MUTATED | 2 | 2 | 0 | 3 | 1
LCE4A WILD-TYPE | 26 | 18 | 11 | 17 | 20

'LCE4A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.44 (Fisher's exact test), Q value = 0.72

Table S152. Gene #51: 'LCE4A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LCE4A MUTATED | 2 | 2 | 3 | 1
LCE4A WILD-TYPE | 33 | 31 | 13 | 11

'LCE4A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.879 (Fisher's exact test), Q value = 0.96

Table S153. Gene #51: 'LCE4A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LCE4A MUTATED | 3 | 2 | 1 | 0 | 0 | 2 | 0
LCE4A WILD-TYPE | 31 | 9 | 8 | 7 | 6 | 18 | 9

'NFE2L2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.77 (Fisher's exact test), Q value = 0.91

Table S154. Gene #52: 'NFE2L2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NFE2L2 MUTATED | 1 | 2 | 0 | 2 | 1
NFE2L2 WILD-TYPE | 27 | 18 | 11 | 18 | 20

'NFE2L2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0909 (Fisher's exact test), Q value = 0.47

Table S155. Gene #52: 'NFE2L2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NFE2L2 MUTATED | 5 | 0 | 1 | 0
NFE2L2 WILD-TYPE | 30 | 33 | 15 | 12

'NFE2L2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.216 (Fisher's exact test), Q value = 0.58

Table S156. Gene #52: 'NFE2L2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NFE2L2 MUTATED | 3 | 0 | 0 | 1 | 0 | 0 | 2
NFE2L2 WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 20 | 7

'VEGFB MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.166 (Fisher's exact test), Q value = 0.56

Table S157. Gene #53: 'VEGFB MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
VEGFB MUTATED | 0 | 3 | 0 | 2 | 1
VEGFB WILD-TYPE | 28 | 17 | 11 | 18 | 20

'VEGFB MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0909 (Fisher's exact test), Q value = 0.47

Table S158. Gene #53: 'VEGFB MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
VEGFB MUTATED | 5 | 0 | 1 | 0
VEGFB WILD-TYPE | 30 | 33 | 15 | 12

'VEGFB MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.494 (Fisher's exact test), Q value = 0.75

Table S159. Gene #53: 'VEGFB MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
VEGFB MUTATED | 4 | 0 | 1 | 0 | 0 | 0 | 1
VEGFB WILD-TYPE | 30 | 11 | 8 | 7 | 6 | 20 | 8

'SENP1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.482 (Fisher's exact test), Q value = 0.75

Table S160. Gene #54: 'SENP1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SENP1 MUTATED | 1 | 0 | 1 | 2 | 2
SENP1 WILD-TYPE | 27 | 20 | 10 | 18 | 19

'SENP1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.736 (Fisher's exact test), Q value = 0.89

Table S161. Gene #54: 'SENP1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SENP1 MUTATED | 3 | 1 | 1 | 0
SENP1 WILD-TYPE | 32 | 32 | 15 | 12

'SENP1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.791 (Fisher's exact test), Q value = 0.92

Table S162. Gene #54: 'SENP1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SENP1 MUTATED | 3 | 0 | 0 | 1 | 0 | 1 | 0
SENP1 WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 19 | 9

'USP9X MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.647 (Fisher's exact test), Q value = 0.84

Table S163. Gene #55: 'USP9X MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
USP9X MUTATED | 5 | 4 | 2 | 1 | 4
USP9X WILD-TYPE | 23 | 16 | 9 | 19 | 17

'USP9X MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.324 (Fisher's exact test), Q value = 0.65

Table S164. Gene #55: 'USP9X MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
USP9X MUTATED | 9 | 3 | 2 | 2
USP9X WILD-TYPE | 26 | 30 | 14 | 10

'USP9X MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.066 (Fisher's exact test), Q value = 0.45

Table S165. Gene #55: 'USP9X MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
USP9X MUTATED | 10 | 0 | 0 | 2 | 1 | 1 | 2
USP9X WILD-TYPE | 24 | 11 | 9 | 5 | 5 | 19 | 7

'ADAM28 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.644 (Fisher's exact test), Q value = 0.84

Table S166. Gene #56: 'ADAM28 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ADAM28 MUTATED | 2 | 0 | 0 | 2 | 2
ADAM28 WILD-TYPE | 26 | 20 | 11 | 18 | 19

'ADAM28 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0911 (Fisher's exact test), Q value = 0.47

Table S167. Gene #56: 'ADAM28 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ADAM28 MUTATED | 5 | 0 | 1 | 0
ADAM28 WILD-TYPE | 30 | 33 | 15 | 12

'ADAM28 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.277 (Fisher's exact test), Q value = 0.63

Table S168. Gene #56: 'ADAM28 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ADAM28 MUTATED | 5 | 0 | 0 | 1 | 0 | 0 | 0
ADAM28 WILD-TYPE | 29 | 11 | 9 | 6 | 6 | 20 | 9

'SVIL MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.396 (Fisher's exact test), Q value = 0.69

Table S169. Gene #57: 'SVIL MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SVIL MUTATED | 3 | 2 | 1 | 2 | 6
SVIL WILD-TYPE | 25 | 18 | 10 | 18 | 15

'SVIL MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0776 (Fisher's exact test), Q value = 0.47

Table S170. Gene #57: 'SVIL MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SVIL MUTATED | 8 | 1 | 3 | 2
SVIL WILD-TYPE | 27 | 32 | 13 | 10

'SVIL MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0739 (Fisher's exact test), Q value = 0.47

Table S171. Gene #57: 'SVIL MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SVIL MUTATED | 8 | 0 | 2 | 2 | 1 | 0 | 1
SVIL WILD-TYPE | 26 | 11 | 7 | 5 | 5 | 20 | 8

'KDM5A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.836 (Fisher's exact test), Q value = 0.94

Table S172. Gene #58: 'KDM5A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KDM5A MUTATED | 2 | 3 | 2 | 2 | 2
KDM5A WILD-TYPE | 26 | 17 | 9 | 18 | 19

'KDM5A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0231 (Fisher's exact test), Q value = 0.4

Table S173. Gene #58: 'KDM5A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KDM5A MUTATED | 7 | 0 | 2 | 2
KDM5A WILD-TYPE | 28 | 33 | 14 | 10

Figure S37. Get High-res Image Gene #58: 'KDM5A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'KDM5A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0722 (Fisher's exact test), Q value = 0.47

Table S174. Gene #58: 'KDM5A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KDM5A MUTATED | 7 | 0 | 1 | 2 | 1 | 0 | 0
KDM5A WILD-TYPE | 27 | 11 | 8 | 5 | 5 | 20 | 9

'PIK3CA MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.452 (Fisher's exact test), Q value = 0.73

Table S175. Gene #59: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PIK3CA MUTATED | 10 | 10 | 6 | 6 | 11
PIK3CA WILD-TYPE | 18 | 10 | 5 | 14 | 10

'PIK3CA MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.219 (Fisher's exact test), Q value = 0.58

Table S176. Gene #59: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PIK3CA MUTATED | 19 | 13 | 4 | 4
PIK3CA WILD-TYPE | 16 | 20 | 12 | 8

'PIK3CA MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.847 (Fisher's exact test), Q value = 0.94

Table S177. Gene #59: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PIK3CA MUTATED | 17 | 3 | 3 | 2 | 2 | 9 | 4
PIK3CA WILD-TYPE | 17 | 8 | 6 | 5 | 4 | 11 | 5

'TBC1D23 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.978 (Fisher's exact test), Q value = 1

Table S178. Gene #60: 'TBC1D23 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TBC1D23 MUTATED | 2 | 2 | 1 | 1 | 1
TBC1D23 WILD-TYPE | 26 | 18 | 10 | 19 | 20

'TBC1D23 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.132 (Fisher's exact test), Q value = 0.51

Table S179. Gene #60: 'TBC1D23 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TBC1D23 MUTATED | 4 | 0 | 2 | 1
TBC1D23 WILD-TYPE | 31 | 33 | 14 | 11

'TBC1D23 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.316 (Fisher's exact test), Q value = 0.65

Table S180. Gene #60: 'TBC1D23 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TBC1D23 MUTATED | 4 | 0 | 0 | 1 | 1 | 0 | 1
TBC1D23 WILD-TYPE | 30 | 11 | 9 | 6 | 5 | 20 | 8

'C13ORF33 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.13 (Fisher's exact test), Q value = 0.51

Table S181. Gene #61: 'C13ORF33 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C13ORF33 MUTATED | 2 | 0 | 2 | 2 | 0
C13ORF33 WILD-TYPE | 26 | 20 | 9 | 18 | 21

'C13ORF33 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.044 (Fisher's exact test), Q value = 0.42

Table S182. Gene #61: 'C13ORF33 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C13ORF33 MUTATED | 3 | 0 | 3 | 0
C13ORF33 WILD-TYPE | 32 | 33 | 13 | 12

Figure S38. Get High-res Image Gene #61: 'C13ORF33 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'C13ORF33 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.148 (Fisher's exact test), Q value = 0.54

Table S183. Gene #61: 'C13ORF33 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C13ORF33 MUTATED | 4 | 0 | 0 | 2 | 0 | 0 | 0
C13ORF33 WILD-TYPE | 30 | 11 | 9 | 5 | 6 | 20 | 9

'KIAA0182 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.538 (Fisher's exact test), Q value = 0.77

Table S184. Gene #62: 'KIAA0182 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KIAA0182 MUTATED | 3 | 2 | 0 | 0 | 1
KIAA0182 WILD-TYPE | 25 | 18 | 11 | 20 | 20

'KIAA0182 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.103 (Fisher's exact test), Q value = 0.48

Table S185. Gene #62: 'KIAA0182 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KIAA0182 MUTATED | 4 | 0 | 2 | 0
KIAA0182 WILD-TYPE | 31 | 33 | 14 | 12

'KIAA0182 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.198 (Fisher's exact test), Q value = 0.57

Table S186. Gene #62: 'KIAA0182 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KIAA0182 MUTATED | 6 | 0 | 0 | 0 | 0 | 0 | 0
KIAA0182 WILD-TYPE | 28 | 11 | 9 | 7 | 6 | 20 | 9

'CKAP2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.405 (Fisher's exact test), Q value = 0.69

Table S187. Gene #63: 'CKAP2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CKAP2 MUTATED | 0 | 2 | 0 | 1 | 2
CKAP2 WILD-TYPE | 28 | 18 | 11 | 19 | 19

'CKAP2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.16 (Fisher's exact test), Q value = 0.56

Table S188. Gene #63: 'CKAP2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CKAP2 MUTATED | 3 | 0 | 2 | 0
CKAP2 WILD-TYPE | 32 | 33 | 14 | 12

'CKAP2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.354 (Fisher's exact test), Q value = 0.68

Table S189. Gene #63: 'CKAP2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CKAP2 MUTATED | 5 | 0 | 0 | 0 | 0 | 0 | 0
CKAP2 WILD-TYPE | 29 | 11 | 9 | 7 | 6 | 20 | 9

'WBP1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.102 (Fisher's exact test), Q value = 0.48

Table S190. Gene #64: 'WBP1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
WBP1 MUTATED | 1 | 0 | 0 | 1 | 4
WBP1 WILD-TYPE | 27 | 20 | 11 | 19 | 17

'WBP1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.113 (Fisher's exact test), Q value = 0.48

Table S191. Gene #64: 'WBP1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
WBP1 MUTATED | 3 | 0 | 1 | 2
WBP1 WILD-TYPE | 32 | 33 | 15 | 10

'WBP1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.111 (Fisher's exact test), Q value = 0.48

Table S192. Gene #64: 'WBP1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
WBP1 MUTATED | 4 | 0 | 0 | 0 | 2 | 0 | 0
WBP1 WILD-TYPE | 30 | 11 | 9 | 7 | 4 | 20 | 9

'SAFB2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.275 (Fisher's exact test), Q value = 0.63

Table S193. Gene #65: 'SAFB2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SAFB2 MUTATED | 3 | 0 | 2 | 3 | 1
SAFB2 WILD-TYPE | 25 | 20 | 9 | 17 | 20

'SAFB2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.528 (Fisher's exact test), Q value = 0.76

Table S194. Gene #65: 'SAFB2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SAFB2 MUTATED | 4 | 1 | 2 | 1
SAFB2 WILD-TYPE | 31 | 32 | 14 | 11

'SAFB2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.486 (Fisher's exact test), Q value = 0.75

Table S195. Gene #65: 'SAFB2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SAFB2 MUTATED | 5 | 0 | 0 | 1 | 1 | 1 | 0
SAFB2 WILD-TYPE | 29 | 11 | 9 | 6 | 5 | 19 | 9

'XYLT2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.605 (Fisher's exact test), Q value = 0.81

Table S196. Gene #66: 'XYLT2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
XYLT2 MUTATED | 3 | 1 | 0 | 1 | 0
XYLT2 WILD-TYPE | 25 | 19 | 11 | 19 | 21

'XYLT2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00434 (Fisher's exact test), Q value = 0.32

Table S197. Gene #66: 'XYLT2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
XYLT2 MUTATED | 1 | 0 | 4 | 0
XYLT2 WILD-TYPE | 34 | 33 | 12 | 12

Figure S39. Get High-res Image Gene #66: 'XYLT2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'XYLT2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.181 (Fisher's exact test), Q value = 0.56

Table S198. Gene #66: 'XYLT2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
XYLT2 MUTATED | 3 | 0 | 0 | 2 | 0 | 0 | 0
XYLT2 WILD-TYPE | 31 | 11 | 9 | 5 | 6 | 20 | 9

'LRPPRC MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.668 (Fisher's exact test), Q value = 0.85

Table S199. Gene #67: 'LRPPRC MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LRPPRC MUTATED | 3 | 4 | 1 | 2 | 1
LRPPRC WILD-TYPE | 25 | 16 | 10 | 18 | 20

'LRPPRC MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.206 (Fisher's exact test), Q value = 0.58

Table S200. Gene #67: 'LRPPRC MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LRPPRC MUTATED | 3 | 3 | 4 | 0
LRPPRC WILD-TYPE | 32 | 30 | 12 | 12

'LRPPRC MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.193 (Fisher's exact test), Q value = 0.56

Table S201. Gene #67: 'LRPPRC MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LRPPRC MUTATED | 4 | 1 | 0 | 3 | 0 | 1 | 1
LRPPRC WILD-TYPE | 30 | 10 | 9 | 4 | 6 | 19 | 8

'SLC12A7 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.892 (Fisher's exact test), Q value = 0.97

Table S202. Gene #68: 'SLC12A7 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SLC12A7 MUTATED | 1 | 1 | 0 | 2 | 1
SLC12A7 WILD-TYPE | 27 | 19 | 11 | 18 | 20

'SLC12A7 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.162 (Fisher's exact test), Q value = 0.56

Table S203. Gene #68: 'SLC12A7 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SLC12A7 MUTATED | 3 | 0 | 2 | 0
SLC12A7 WILD-TYPE | 32 | 33 | 14 | 12

'SLC12A7 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.181 (Fisher's exact test), Q value = 0.56

Table S204. Gene #68: 'SLC12A7 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SLC12A7 MUTATED | 3 | 0 | 0 | 2 | 0 | 0 | 0
SLC12A7 WILD-TYPE | 31 | 11 | 9 | 5 | 6 | 20 | 9

'ZFR MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.326 (Fisher's exact test), Q value = 0.66

Table S205. Gene #69: 'ZFR MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZFR MUTATED | 3 | 0 | 0 | 1 | 0
ZFR WILD-TYPE | 25 | 20 | 11 | 19 | 21

'ZFR MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.354 (Fisher's exact test), Q value = 0.68

Table S206. Gene #69: 'ZFR MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZFR MUTATED | 2 | 0 | 1 | 1
ZFR WILD-TYPE | 33 | 33 | 15 | 11

'ZFR MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.31 (Fisher's exact test), Q value = 0.65

Table S207. Gene #69: 'ZFR MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZFR MUTATED | 2 | 0 | 0 | 1 | 1 | 0 | 0
ZFR WILD-TYPE | 32 | 11 | 9 | 6 | 5 | 20 | 9

'SYNJ2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.886 (Fisher's exact test), Q value = 0.96

Table S208. Gene #70: 'SYNJ2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SYNJ2 MUTATED | 3 | 1 | 0 | 2 | 2
SYNJ2 WILD-TYPE | 25 | 19 | 11 | 18 | 19

'SYNJ2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0756 (Fisher's exact test), Q value = 0.47

Table S209. Gene #70: 'SYNJ2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SYNJ2 MUTATED | 4 | 0 | 2 | 2
SYNJ2 WILD-TYPE | 31 | 33 | 14 | 10

'SYNJ2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0795 (Fisher's exact test), Q value = 0.47

Table S210. Gene #70: 'SYNJ2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SYNJ2 MUTATED | 5 | 0 | 0 | 1 | 2 | 0 | 0
SYNJ2 WILD-TYPE | 29 | 11 | 9 | 6 | 4 | 20 | 9

'RALGAPB MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.667 (Fisher's exact test), Q value = 0.85

Table S211. Gene #71: 'RALGAPB MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RALGAPB MUTATED | 3 | 1 | 1 | 0 | 1
RALGAPB WILD-TYPE | 25 | 19 | 10 | 20 | 20

'RALGAPB MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.186 (Fisher's exact test), Q value = 0.56

Table S212. Gene #71: 'RALGAPB MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RALGAPB MUTATED | 2 | 0 | 2 | 1
RALGAPB WILD-TYPE | 33 | 33 | 14 | 11

'RALGAPB MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.299 (Fisher's exact test), Q value = 0.65

Table S213. Gene #71: 'RALGAPB MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RALGAPB MUTATED | 3 | 0 | 0 | 1 | 1 | 0 | 0
RALGAPB WILD-TYPE | 31 | 11 | 9 | 6 | 5 | 20 | 9

'TCEB3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.571 (Fisher's exact test), Q value = 0.78

Table S214. Gene #72: 'TCEB3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TCEB3 MUTATED | 1 | 3 | 0 | 1 | 2
TCEB3 WILD-TYPE | 27 | 17 | 11 | 19 | 19

'TCEB3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.288 (Fisher's exact test), Q value = 0.64

Table S215. Gene #72: 'TCEB3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TCEB3 MUTATED | 5 | 1 | 1 | 0
TCEB3 WILD-TYPE | 30 | 32 | 15 | 12

'TCEB3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.219 (Fisher's exact test), Q value = 0.58

Table S216. Gene #72: 'TCEB3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TCEB3 MUTATED | 6 | 0 | 0 | 0 | 0 | 0 | 1
TCEB3 WILD-TYPE | 28 | 11 | 9 | 7 | 6 | 20 | 8

'QSOX1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.292 (Fisher's exact test), Q value = 0.64

Table S217. Gene #73: 'QSOX1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
QSOX1 MUTATED | 1 | 3 | 0 | 0 | 1
QSOX1 WILD-TYPE | 27 | 17 | 11 | 20 | 20

'QSOX1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.736 (Fisher's exact test), Q value = 0.89

Table S218. Gene #73: 'QSOX1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
QSOX1 MUTATED | 3 | 1 | 1 | 0
QSOX1 WILD-TYPE | 32 | 32 | 15 | 12

'QSOX1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.474 (Fisher's exact test), Q value = 0.75

Table S219. Gene #73: 'QSOX1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
QSOX1 MUTATED | 2 | 1 | 0 | 1 | 0 | 0 | 1
QSOX1 WILD-TYPE | 32 | 10 | 9 | 6 | 6 | 20 | 8

'MFRP MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.593 (Fisher's exact test), Q value = 0.8

Table S220. Gene #74: 'MFRP MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MFRP MUTATED | 1 | 1 | 1 | 0 | 2
MFRP WILD-TYPE | 27 | 19 | 10 | 20 | 19

'MFRP MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.364 (Fisher's exact test), Q value = 0.68

Table S221. Gene #74: 'MFRP MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MFRP MUTATED | 4 | 1 | 0 | 0
MFRP WILD-TYPE | 31 | 32 | 16 | 12

'MFRP MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.536 (Fisher's exact test), Q value = 0.77

Table S222. Gene #74: 'MFRP MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MFRP MUTATED | 4 | 0 | 0 | 0 | 0 | 0 | 1
MFRP WILD-TYPE | 30 | 11 | 9 | 7 | 6 | 20 | 8

'CCDC28A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.401 (Fisher's exact test), Q value = 0.69

Table S223. Gene #75: 'CCDC28A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CCDC28A MUTATED | 2 | 0 | 0 | 0 | 2
CCDC28A WILD-TYPE | 26 | 20 | 11 | 20 | 19

'CCDC28A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.182 (Fisher's exact test), Q value = 0.56

Table S224. Gene #75: 'CCDC28A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CCDC28A MUTATED | 2 | 0 | 2 | 0
CCDC28A WILD-TYPE | 33 | 33 | 14 | 12

'CCDC28A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.576 (Fisher's exact test), Q value = 0.78

Table S225. Gene #75: 'CCDC28A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CCDC28A MUTATED | 4 | 0 | 0 | 0 | 0 | 0 | 0
CCDC28A WILD-TYPE | 30 | 11 | 9 | 7 | 6 | 20 | 9

'FGFR2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.494 (Fisher's exact test), Q value = 0.75

Table S226. Gene #76: 'FGFR2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FGFR2 MUTATED | 3 | 3 | 1 | 1 | 5
FGFR2 WILD-TYPE | 25 | 17 | 10 | 19 | 16

'FGFR2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.157 (Fisher's exact test), Q value = 0.56

Table S227. Gene #76: 'FGFR2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FGFR2 MUTATED | 7 | 2 | 1 | 3
FGFR2 WILD-TYPE | 28 | 31 | 15 | 9

'FGFR2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.32 (Fisher's exact test), Q value = 0.65

Table S228. Gene #76: 'FGFR2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FGFR2 MUTATED | 6 | 0 | 1 | 1 | 2 | 1 | 2
FGFR2 WILD-TYPE | 28 | 11 | 8 | 6 | 4 | 19 | 7

'ZMIZ1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.241 (Fisher's exact test), Q value = 0.62

Table S229. Gene #77: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZMIZ1 MUTATED | 0 | 1 | 1 | 2 | 3
ZMIZ1 WILD-TYPE | 28 | 19 | 10 | 18 | 18

'ZMIZ1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.631 (Fisher's exact test), Q value = 0.84

Table S230. Gene #77: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZMIZ1 MUTATED | 4 | 1 | 1 | 1
ZMIZ1 WILD-TYPE | 31 | 32 | 15 | 11

'ZMIZ1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.277 (Fisher's exact test), Q value = 0.63

Table S231. Gene #77: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZMIZ1 MUTATED | 5 | 0 | 0 | 0 | 1 | 0 | 1
ZMIZ1 WILD-TYPE | 29 | 11 | 9 | 7 | 5 | 20 | 8

'ARHGAP35 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.455 (Fisher's exact test), Q value = 0.73

Table S232. Gene #78: 'ARHGAP35 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ARHGAP35 MUTATED | 2 | 4 | 1 | 1 | 4
ARHGAP35 WILD-TYPE | 26 | 16 | 10 | 19 | 17

'ARHGAP35 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.382 (Fisher's exact test), Q value = 0.68

Table S233. Gene #78: 'ARHGAP35 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ARHGAP35 MUTATED | 5 | 5 | 0 | 2
ARHGAP35 WILD-TYPE | 30 | 28 | 16 | 10

'ARHGAP35 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.477 (Fisher's exact test), Q value = 0.75

Table S234. Gene #78: 'ARHGAP35 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ARHGAP35 MUTATED | 3 | 2 | 1 | 0 | 2 | 2 | 2
ARHGAP35 WILD-TYPE | 31 | 9 | 8 | 7 | 4 | 18 | 7

'TFE3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.202 (Fisher's exact test), Q value = 0.57

Table S235. Gene #79: 'TFE3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TFE3 MUTATED | 0 | 1 | 1 | 2 | 0
TFE3 WILD-TYPE | 28 | 19 | 10 | 18 | 21

'TFE3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.122 (Fisher's exact test), Q value = 0.49

Table S236. Gene #79: 'TFE3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TFE3 MUTATED | 4 | 0 | 0 | 0
TFE3 WILD-TYPE | 31 | 33 | 16 | 12

'TFE3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.573 (Fisher's exact test), Q value = 0.78

Table S237. Gene #79: 'TFE3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TFE3 MUTATED | 4 | 0 | 0 | 0 | 0 | 0 | 0
TFE3 WILD-TYPE | 30 | 11 | 9 | 7 | 6 | 20 | 9

'SIPA1L1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.892 (Fisher's exact test), Q value = 0.97

Table S238. Gene #80: 'SIPA1L1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SIPA1L1 MUTATED | 3 | 2 | 1 | 3 | 4
SIPA1L1 WILD-TYPE | 25 | 18 | 10 | 17 | 17

'SIPA1L1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.112 (Fisher's exact test), Q value = 0.48

Table S239. Gene #80: 'SIPA1L1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SIPA1L1 MUTATED | 7 | 1 | 3 | 2
SIPA1L1 WILD-TYPE | 28 | 32 | 13 | 10

'SIPA1L1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0765 (Fisher's exact test), Q value = 0.47

Table S240. Gene #80: 'SIPA1L1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SIPA1L1 MUTATED | 7 | 1 | 0 | 2 | 2 | 0 | 1
SIPA1L1 WILD-TYPE | 27 | 10 | 9 | 5 | 4 | 20 | 8

'EIF2B3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.848 (Fisher's exact test), Q value = 0.94

Table S241. Gene #81: 'EIF2B3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
EIF2B3 MUTATED | 1 | 1 | 1 | 2 | 1
EIF2B3 WILD-TYPE | 27 | 19 | 10 | 18 | 20

'EIF2B3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.569 (Fisher's exact test), Q value = 0.78

Table S242. Gene #81: 'EIF2B3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
EIF2B3 MUTATED | 2 | 1 | 2 | 1
EIF2B3 WILD-TYPE | 33 | 32 | 14 | 11

'EIF2B3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.211 (Fisher's exact test), Q value = 0.58

Table S243. Gene #81: 'EIF2B3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
EIF2B3 MUTATED | 2 | 0 | 0 | 2 | 1 | 1 | 0
EIF2B3 WILD-TYPE | 32 | 11 | 9 | 5 | 5 | 19 | 9

'NBEAL1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.426 (Fisher's exact test), Q value = 0.71

Table S244. Gene #82: 'NBEAL1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NBEAL1 MUTATED | 3 | 2 | 2 | 0 | 2
NBEAL1 WILD-TYPE | 25 | 18 | 9 | 20 | 19

'NBEAL1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.35 (Fisher's exact test), Q value = 0.68

Table S245. Gene #82: 'NBEAL1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NBEAL1 MUTATED | 4 | 1 | 2 | 2
NBEAL1 WILD-TYPE | 31 | 32 | 14 | 10

'NBEAL1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.116 (Fisher's exact test), Q value = 0.48

Table S246. Gene #82: 'NBEAL1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NBEAL1 MUTATED | 4 | 0 | 0 | 2 | 2 | 1 | 0
NBEAL1 WILD-TYPE | 30 | 11 | 9 | 5 | 4 | 19 | 9

'HPS1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.515 (Fisher's exact test), Q value = 0.76

Table S247. Gene #83: 'HPS1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
HPS1 MUTATED | 1 | 1 | 2 | 1 | 1
HPS1 WILD-TYPE | 27 | 19 | 9 | 19 | 20

'HPS1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.166 (Fisher's exact test), Q value = 0.56

Table S248. Gene #83: 'HPS1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
HPS1 MUTATED | 3 | 0 | 2 | 1
HPS1 WILD-TYPE | 32 | 33 | 14 | 11

'HPS1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.275 (Fisher's exact test), Q value = 0.63

Table S249. Gene #83: 'HPS1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
HPS1 MUTATED | 4 | 0 | 0 | 1 | 1 | 0 | 0
HPS1 WILD-TYPE | 30 | 11 | 9 | 6 | 5 | 20 | 9

'DOCK3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.676 (Fisher's exact test), Q value = 0.85

Table S250. Gene #84: 'DOCK3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DOCK3 MUTATED | 5 | 5 | 3 | 4 | 2
DOCK3 WILD-TYPE | 23 | 15 | 8 | 16 | 19

'DOCK3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.289 (Fisher's exact test), Q value = 0.64

Table S251. Gene #84: 'DOCK3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DOCK3 MUTATED | 9 | 3 | 4 | 2
DOCK3 WILD-TYPE | 26 | 30 | 12 | 10

'DOCK3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.145 (Fisher's exact test), Q value = 0.53

Table S252. Gene #84: 'DOCK3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DOCK3 MUTATED | 9 | 0 | 1 | 3 | 2 | 2 | 1
DOCK3 WILD-TYPE | 25 | 11 | 8 | 4 | 4 | 18 | 8

'SLC16A4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0648 (Fisher's exact test), Q value = 0.45

Table S253. Gene #85: 'SLC16A4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SLC16A4 MUTATED | 0 | 1 | 2 | 0 | 1
SLC16A4 WILD-TYPE | 28 | 19 | 9 | 20 | 20

'SLC16A4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.232 (Fisher's exact test), Q value = 0.6

Table S254. Gene #85: 'SLC16A4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SLC16A4 MUTATED | 3 | 0 | 0 | 1
SLC16A4 WILD-TYPE | 32 | 33 | 16 | 11

'SLC16A4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.402 (Fisher's exact test), Q value = 0.69

Table S255. Gene #85: 'SLC16A4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SLC16A4 MUTATED | 3 | 0 | 0 | 0 | 1 | 0 | 0
SLC16A4 WILD-TYPE | 31 | 11 | 9 | 7 | 5 | 20 | 9

'DYNC1LI1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.939 (Fisher's exact test), Q value = 0.99

Table S256. Gene #86: 'DYNC1LI1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DYNC1LI1 MUTATED | 2 | 0 | 0 | 1 | 1
DYNC1LI1 WILD-TYPE | 26 | 20 | 11 | 19 | 20

'DYNC1LI1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0676 (Fisher's exact test), Q value = 0.45

Table S257. Gene #86: 'DYNC1LI1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DYNC1LI1 MUTATED | 2 | 0 | 0 | 2
DYNC1LI1 WILD-TYPE | 33 | 33 | 16 | 10

'DYNC1LI1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.105 (Fisher's exact test), Q value = 0.48

Table S258. Gene #86: 'DYNC1LI1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DYNC1LI1 MUTATED | 2 | 0 | 0 | 0 | 2 | 0 | 0
DYNC1LI1 WILD-TYPE | 32 | 11 | 9 | 7 | 4 | 20 | 9

'CHD9 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.407 (Fisher's exact test), Q value = 0.69

Table S259. Gene #87: 'CHD9 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CHD9 MUTATED | 4 | 3 | 1 | 0 | 3
CHD9 WILD-TYPE | 24 | 17 | 10 | 20 | 18

'CHD9 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.199 (Fisher's exact test), Q value = 0.57

Table S260. Gene #87: 'CHD9 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CHD9 MUTATED | 6 | 1 | 2 | 2
CHD9 WILD-TYPE | 29 | 32 | 14 | 10

'CHD9 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0613 (Fisher's exact test), Q value = 0.45

Table S261. Gene #87: 'CHD9 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CHD9 MUTATED | 7 | 0 | 0 | 1 | 2 | 0 | 1
CHD9 WILD-TYPE | 27 | 11 | 9 | 6 | 4 | 20 | 8

'RPE65 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.64 (Fisher's exact test), Q value = 0.84

Table S262. Gene #88: 'RPE65 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RPE65 MUTATED | 1 | 3 | 1 | 1 | 1
RPE65 WILD-TYPE | 27 | 17 | 10 | 19 | 20

'RPE65 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0409 (Fisher's exact test), Q value = 0.42

Table S263. Gene #88: 'RPE65 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RPE65 MUTATED | 4 | 0 | 3 | 0
RPE65 WILD-TYPE | 31 | 33 | 13 | 12

Figure S40. Get High-res Image Gene #88: 'RPE65 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'RPE65 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.113 (Fisher's exact test), Q value = 0.48

Table S264. Gene #88: 'RPE65 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RPE65 MUTATED | 5 | 0 | 0 | 2 | 0 | 0 | 0
RPE65 WILD-TYPE | 29 | 11 | 9 | 5 | 6 | 20 | 9

'C1QTNF5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.328 (Fisher's exact test), Q value = 0.66

Table S265. Gene #89: 'C1QTNF5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C1QTNF5 MUTATED | 3 | 0 | 0 | 1 | 0
C1QTNF5 WILD-TYPE | 25 | 20 | 11 | 19 | 21

'C1QTNF5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.124 (Fisher's exact test), Q value = 0.5

Table S266. Gene #89: 'C1QTNF5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C1QTNF5 MUTATED | 4 | 0 | 0 | 0
C1QTNF5 WILD-TYPE | 31 | 33 | 16 | 12

'C1QTNF5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.576 (Fisher's exact test), Q value = 0.78

Table S267. Gene #89: 'C1QTNF5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C1QTNF5 MUTATED | 4 | 0 | 0 | 0 | 0 | 0 | 0
C1QTNF5 WILD-TYPE | 30 | 11 | 9 | 7 | 6 | 20 | 9

'LANCL1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.832 (Fisher's exact test), Q value = 0.94

Table S268. Gene #90: 'LANCL1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LANCL1 MUTATED | 2 | 0 | 1 | 1 | 1
LANCL1 WILD-TYPE | 26 | 20 | 10 | 19 | 20

'LANCL1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.737 (Fisher's exact test), Q value = 0.89

Table S269. Gene #90: 'LANCL1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LANCL1 MUTATED | 3 | 2 | 0 | 0
LANCL1 WILD-TYPE | 32 | 31 | 16 | 12

'LANCL1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S270. Gene #90: 'LANCL1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LANCL1 MUTATED | 3 | 1 | 0 | 0 | 0 | 1 | 0
LANCL1 WILD-TYPE | 31 | 10 | 9 | 7 | 6 | 19 | 9

'TMEM60 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.435 (Fisher's exact test), Q value = 0.72

Table S271. Gene #91: 'TMEM60 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TMEM60 MUTATED | 0 | 2 | 1 | 1 | 1
TMEM60 WILD-TYPE | 28 | 18 | 10 | 19 | 20

'TMEM60 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.918 (Fisher's exact test), Q value = 0.98

Table S272. Gene #91: 'TMEM60 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TMEM60 MUTATED | 2 | 1 | 1 | 1
TMEM60 WILD-TYPE | 33 | 32 | 15 | 11

'TMEM60 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0679 (Fisher's exact test), Q value = 0.45

Table S273. Gene #91: 'TMEM60 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TMEM60 MUTATED | 1 | 0 | 0 | 1 | 1 | 0 | 2
TMEM60 WILD-TYPE | 33 | 11 | 9 | 6 | 5 | 20 | 7

'SLC30A8 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.924 (Fisher's exact test), Q value = 0.98

Table S274. Gene #92: 'SLC30A8 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SLC30A8 MUTATED | 1 | 1 | 0 | 1 | 2
SLC30A8 WILD-TYPE | 27 | 19 | 11 | 19 | 19

'SLC30A8 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0121 (Fisher's exact test), Q value = 0.39

Table S275. Gene #92: 'SLC30A8 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SLC30A8 MUTATED | 2 | 0 | 0 | 3
SLC30A8 WILD-TYPE | 33 | 33 | 16 | 9

Figure S41. Get High-res Image Gene #92: 'SLC30A8 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'SLC30A8 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.00996 (Fisher's exact test), Q value = 0.39

Table S276. Gene #92: 'SLC30A8 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SLC30A8 MUTATED | 2 | 0 | 0 | 0 | 3 | 0 | 0
SLC30A8 WILD-TYPE | 32 | 11 | 9 | 7 | 3 | 20 | 9

Figure S42. Get High-res Image Gene #92: 'SLC30A8 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'U2AF1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.492 (Fisher's exact test), Q value = 0.75

Table S277. Gene #93: 'U2AF1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
U2AF1 MUTATED | 1 | 0 | 0 | 2 | 2
U2AF1 WILD-TYPE | 27 | 20 | 11 | 18 | 19

'U2AF1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.188 (Fisher's exact test), Q value = 0.56

Table S278. Gene #93: 'U2AF1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
U2AF1 MUTATED | 2 | 0 | 2 | 1
U2AF1 WILD-TYPE | 33 | 33 | 14 | 11

'U2AF1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.456 (Fisher's exact test), Q value = 0.73

Table S279. Gene #93: 'U2AF1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
U2AF1 MUTATED | 3 | 0 | 1 | 1 | 0 | 0 | 0
U2AF1 WILD-TYPE | 31 | 11 | 8 | 6 | 6 | 20 | 9

'AP1S1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.393 (Fisher's exact test), Q value = 0.69

Table S280. Gene #94: 'AP1S1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
AP1S1 MUTATED | 2 | 3 | 0 | 1 | 0
AP1S1 WILD-TYPE | 26 | 17 | 11 | 19 | 21

'AP1S1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0437 (Fisher's exact test), Q value = 0.42

Table S281. Gene #94: 'AP1S1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
AP1S1 MUTATED | 3 | 0 | 3 | 0
AP1S1 WILD-TYPE | 32 | 33 | 13 | 12

Figure S43. Get High-res Image Gene #94: 'AP1S1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'AP1S1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.149 (Fisher's exact test), Q value = 0.54

Table S282. Gene #94: 'AP1S1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
AP1S1 MUTATED | 4 | 0 | 0 | 2 | 0 | 0 | 0
AP1S1 WILD-TYPE | 30 | 11 | 9 | 5 | 6 | 20 | 9

'TP53BP2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.769 (Fisher's exact test), Q value = 0.91

Table S283. Gene #95: 'TP53BP2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TP53BP2 MUTATED | 2 | 3 | 0 | 1 | 2
TP53BP2 WILD-TYPE | 26 | 17 | 11 | 19 | 19

'TP53BP2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0465 (Fisher's exact test), Q value = 0.42

Table S284. Gene #95: 'TP53BP2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TP53BP2 MUTATED | 6 | 0 | 1 | 1
TP53BP2 WILD-TYPE | 29 | 33 | 15 | 11

Figure S44. Get High-res Image Gene #95: 'TP53BP2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'TP53BP2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.145 (Fisher's exact test), Q value = 0.53

Table S285. Gene #95: 'TP53BP2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TP53BP2 MUTATED | 6 | 0 | 0 | 1 | 1 | 0 | 0
TP53BP2 WILD-TYPE | 28 | 11 | 9 | 6 | 5 | 20 | 9

'ZMYM2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.167 (Fisher's exact test), Q value = 0.56

Table S286. Gene #96: 'ZMYM2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZMYM2 MUTATED | 1 | 3 | 2 | 1 | 5
ZMYM2 WILD-TYPE | 27 | 17 | 9 | 19 | 16

'ZMYM2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.489 (Fisher's exact test), Q value = 0.75

Table S287. Gene #96: 'ZMYM2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZMYM2 MUTATED | 5 | 2 | 3 | 2
ZMYM2 WILD-TYPE | 30 | 31 | 13 | 10

'ZMYM2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.155 (Fisher's exact test), Q value = 0.55

Table S288. Gene #96: 'ZMYM2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZMYM2 MUTATED | 6 | 0 | 0 | 2 | 2 | 1 | 1
ZMYM2 WILD-TYPE | 28 | 11 | 9 | 5 | 4 | 19 | 8

'BRD3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.81 (Fisher's exact test), Q value = 0.93

Table S289. Gene #97: 'BRD3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
BRD3 MUTATED | 1 | 2 | 0 | 1 | 2
BRD3 WILD-TYPE | 27 | 18 | 11 | 19 | 19

'BRD3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0903 (Fisher's exact test), Q value = 0.47

Table S290. Gene #97: 'BRD3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
BRD3 MUTATED | 5 | 0 | 1 | 0
BRD3 WILD-TYPE | 30 | 33 | 15 | 12

'BRD3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.277 (Fisher's exact test), Q value = 0.63

Table S291. Gene #97: 'BRD3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
BRD3 MUTATED | 5 | 0 | 0 | 1 | 0 | 0 | 0
BRD3 WILD-TYPE | 29 | 11 | 9 | 6 | 6 | 20 | 9

'C6ORF89 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.957 (Fisher's exact test), Q value = 1

Table S292. Gene #98: 'C6ORF89 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C6ORF89 MUTATED | 1 | 1 | 1 | 1 | 1
C6ORF89 WILD-TYPE | 27 | 19 | 10 | 19 | 20

'C6ORF89 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.246 (Fisher's exact test), Q value = 0.63

Table S293. Gene #98: 'C6ORF89 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C6ORF89 MUTATED | 1 | 1 | 1 | 2
C6ORF89 WILD-TYPE | 34 | 32 | 15 | 10

'C6ORF89 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0987 (Fisher's exact test), Q value = 0.48

Table S294. Gene #98: 'C6ORF89 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C6ORF89 MUTATED | 1 | 0 | 0 | 1 | 2 | 1 | 0
C6ORF89 WILD-TYPE | 33 | 11 | 9 | 6 | 4 | 19 | 9

'STAMBPL1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.506 (Fisher's exact test), Q value = 0.75

Table S295. Gene #99: 'STAMBPL1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
STAMBPL1 MUTATED | 3 | 2 | 0 | 1 | 0
STAMBPL1 WILD-TYPE | 25 | 18 | 11 | 19 | 21

'STAMBPL1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.935 (Fisher's exact test), Q value = 0.99

Table S296. Gene #99: 'STAMBPL1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
STAMBPL1 MUTATED | 3 | 2 | 1 | 0
STAMBPL1 WILD-TYPE | 32 | 31 | 15 | 12

'STAMBPL1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.794 (Fisher's exact test), Q value = 0.92

Table S297. Gene #99: 'STAMBPL1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
STAMBPL1 MUTATED | 3 | 0 | 0 | 1 | 0 | 1 | 1
STAMBPL1 WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 19 | 8

'NES MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.99 (Fisher's exact test), Q value = 1

Table S298. Gene #100: 'NES MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NES MUTATED | 3 | 3 | 1 | 2 | 3
NES WILD-TYPE | 25 | 17 | 10 | 18 | 18

'NES MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.124 (Fisher's exact test), Q value = 0.5

Table S299. Gene #100: 'NES MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NES MUTATED | 7 | 1 | 3 | 1
NES WILD-TYPE | 28 | 32 | 13 | 11

'NES MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0564 (Fisher's exact test), Q value = 0.43

Table S300. Gene #100: 'NES MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NES MUTATED | 7 | 0 | 0 | 2 | 1 | 0 | 2
NES WILD-TYPE | 27 | 11 | 9 | 5 | 5 | 20 | 7

'MBD6 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.436 (Fisher's exact test), Q value = 0.72

Table S301. Gene #101: 'MBD6 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MBD6 MUTATED | 2 | 0 | 2 | 2 | 2
MBD6 WILD-TYPE | 26 | 20 | 9 | 18 | 19

'MBD6 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0646 (Fisher's exact test), Q value = 0.45

Table S302. Gene #101: 'MBD6 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MBD6 MUTATED | 4 | 1 | 0 | 3
MBD6 WILD-TYPE | 31 | 32 | 16 | 9

'MBD6 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.212 (Fisher's exact test), Q value = 0.58

Table S303. Gene #101: 'MBD6 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MBD6 MUTATED | 5 | 0 | 0 | 0 | 2 | 1 | 0
MBD6 WILD-TYPE | 29 | 11 | 9 | 7 | 4 | 19 | 9

'SHC1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.798 (Fisher's exact test), Q value = 0.92

Table S304. Gene #102: 'SHC1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SHC1 MUTATED | 2 | 2 | 0 | 3 | 2
SHC1 WILD-TYPE | 26 | 18 | 11 | 17 | 19

'SHC1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.351 (Fisher's exact test), Q value = 0.68

Table S305. Gene #102: 'SHC1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SHC1 MUTATED | 4 | 1 | 2 | 2
SHC1 WILD-TYPE | 31 | 32 | 14 | 10

'SHC1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.222 (Fisher's exact test), Q value = 0.58

Table S306. Gene #102: 'SHC1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SHC1 MUTATED | 5 | 0 | 0 | 1 | 2 | 1 | 0
SHC1 WILD-TYPE | 29 | 11 | 9 | 6 | 4 | 19 | 9

'PEX1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.204 (Fisher's exact test), Q value = 0.57

Table S307. Gene #103: 'PEX1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PEX1 MUTATED | 0 | 3 | 1 | 1 | 1
PEX1 WILD-TYPE | 28 | 17 | 10 | 19 | 20

'PEX1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.538 (Fisher's exact test), Q value = 0.77

Table S308. Gene #103: 'PEX1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PEX1 MUTATED | 4 | 1 | 1 | 0
PEX1 WILD-TYPE | 31 | 32 | 15 | 12

'PEX1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.797 (Fisher's exact test), Q value = 0.92

Table S309. Gene #103: 'PEX1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PEX1 MUTATED | 3 | 0 | 0 | 1 | 0 | 1 | 1
PEX1 WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 19 | 8

'MCPH1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.972 (Fisher's exact test), Q value = 1

Table S310. Gene #104: 'MCPH1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MCPH1 MUTATED | 2 | 1 | 0 | 1 | 2
MCPH1 WILD-TYPE | 26 | 19 | 11 | 19 | 19

'MCPH1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.166 (Fisher's exact test), Q value = 0.56

Table S311. Gene #104: 'MCPH1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MCPH1 MUTATED | 3 | 0 | 2 | 1
MCPH1 WILD-TYPE | 32 | 33 | 14 | 11

'MCPH1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.247 (Fisher's exact test), Q value = 0.63

Table S312. Gene #104: 'MCPH1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MCPH1 MUTATED | 5 | 0 | 0 | 0 | 1 | 0 | 0
MCPH1 WILD-TYPE | 29 | 11 | 9 | 7 | 5 | 20 | 9

'TTLL11 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.383 (Fisher's exact test), Q value = 0.68

Table S313. Gene #105: 'TTLL11 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TTLL11 MUTATED | 2 | 4 | 0 | 1 | 1
TTLL11 WILD-TYPE | 26 | 16 | 11 | 19 | 20

'TTLL11 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.554 (Fisher's exact test), Q value = 0.77

Table S314. Gene #105: 'TTLL11 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TTLL11 MUTATED | 5 | 2 | 1 | 0
TTLL11 WILD-TYPE | 30 | 31 | 15 | 12

'TTLL11 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.689 (Fisher's exact test), Q value = 0.86

Table S315. Gene #105: 'TTLL11 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TTLL11 MUTATED | 5 | 0 | 0 | 1 | 0 | 2 | 0
TTLL11 WILD-TYPE | 29 | 11 | 9 | 6 | 6 | 18 | 9

'ZNF800 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.837 (Fisher's exact test), Q value = 0.94

Table S316. Gene #106: 'ZNF800 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZNF800 MUTATED | 2 | 3 | 2 | 2 | 2
ZNF800 WILD-TYPE | 26 | 17 | 9 | 18 | 19

'ZNF800 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00367 (Fisher's exact test), Q value = 0.32

Table S317. Gene #106: 'ZNF800 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZNF800 MUTATED | 7 | 0 | 4 | 0
ZNF800 WILD-TYPE | 28 | 33 | 12 | 12

Figure S45. Get High-res Image Gene #106: 'ZNF800 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'ZNF800 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0212 (Fisher's exact test), Q value = 0.4

Table S318. Gene #106: 'ZNF800 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZNF800 MUTATED | 7 | 0 | 0 | 3 | 0 | 0 | 1
ZNF800 WILD-TYPE | 27 | 11 | 9 | 4 | 6 | 20 | 8

Figure S46. Get High-res Image Gene #106: 'ZNF800 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'HNF1A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.487 (Fisher's exact test), Q value = 0.75

Table S319. Gene #107: 'HNF1A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
HNF1A MUTATED | 2 | 0 | 1 | 1 | 3
HNF1A WILD-TYPE | 26 | 20 | 10 | 19 | 18

'HNF1A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.112 (Fisher's exact test), Q value = 0.48

Table S320. Gene #107: 'HNF1A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
HNF1A MUTATED | 3 | 0 | 1 | 2
HNF1A WILD-TYPE | 32 | 33 | 15 | 10

'HNF1A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0973 (Fisher's exact test), Q value = 0.48

Table S321. Gene #107: 'HNF1A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
HNF1A MUTATED | 3 | 0 | 0 | 1 | 2 | 0 | 0
HNF1A WILD-TYPE | 31 | 11 | 9 | 6 | 4 | 20 | 9

'PAPD4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.48 (Fisher's exact test), Q value = 0.75

Table S322. Gene #108: 'PAPD4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PAPD4 MUTATED | 1 | 2 | 1 | 0 | 2
PAPD4 WILD-TYPE | 27 | 18 | 10 | 20 | 19

'PAPD4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.821 (Fisher's exact test), Q value = 0.93

Table S323. Gene #108: 'PAPD4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PAPD4 MUTATED | 3 | 1 | 1 | 1
PAPD4 WILD-TYPE | 32 | 32 | 15 | 11

'PAPD4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.605 (Fisher's exact test), Q value = 0.81

Table S324. Gene #108: 'PAPD4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PAPD4 MUTATED | 3 | 0 | 0 | 1 | 1 | 1 | 0
PAPD4 WILD-TYPE | 31 | 11 | 9 | 6 | 5 | 19 | 9

'NSD1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.764 (Fisher's exact test), Q value = 0.9

Table S325. Gene #109: 'NSD1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NSD1 MUTATED | 5 | 5 | 1 | 2 | 3
NSD1 WILD-TYPE | 23 | 15 | 10 | 18 | 18

'NSD1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0357 (Fisher's exact test), Q value = 0.42

Table S326. Gene #109: 'NSD1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NSD1 MUTATED | 7 | 1 | 5 | 2
NSD1 WILD-TYPE | 28 | 32 | 11 | 10

Figure S47. Get High-res Image Gene #109: 'NSD1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'NSD1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0422 (Fisher's exact test), Q value = 0.42

Table S327. Gene #109: 'NSD1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NSD1 MUTATED | 8 | 0 | 0 | 3 | 2 | 1 | 1
NSD1 WILD-TYPE | 26 | 11 | 9 | 4 | 4 | 19 | 8

Figure S48. Get High-res Image Gene #109: 'NSD1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'RANBP10 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.101 (Fisher's exact test), Q value = 0.48

Table S328. Gene #110: 'RANBP10 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RANBP10 MUTATED | 1 | 1 | 0 | 0 | 4
RANBP10 WILD-TYPE | 27 | 19 | 11 | 20 | 17

'RANBP10 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.45 (Fisher's exact test), Q value = 0.73

Table S329. Gene #110: 'RANBP10 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RANBP10 MUTATED | 3 | 1 | 2 | 0
RANBP10 WILD-TYPE | 32 | 32 | 14 | 12

'RANBP10 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.415 (Fisher's exact test), Q value = 0.69

Table S330. Gene #110: 'RANBP10 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RANBP10 MUTATED | 4 | 0 | 0 | 1 | 0 | 0 | 1
RANBP10 WILD-TYPE | 30 | 11 | 9 | 6 | 6 | 20 | 8

'WNT1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.663 (Fisher's exact test), Q value = 0.85

Table S331. Gene #111: 'WNT1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
WNT1 MUTATED | 1 | 0 | 0 | 2 | 1
WNT1 WILD-TYPE | 27 | 20 | 11 | 18 | 20

'WNT1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.185 (Fisher's exact test), Q value = 0.56

Table S332. Gene #111: 'WNT1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
WNT1 MUTATED | 2 | 0 | 2 | 0
WNT1 WILD-TYPE | 33 | 33 | 14 | 12

'WNT1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.157 (Fisher's exact test), Q value = 0.56

Table S333. Gene #111: 'WNT1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
WNT1 MUTATED | 2 | 0 | 0 | 2 | 0 | 0 | 0
WNT1 WILD-TYPE | 32 | 11 | 9 | 5 | 6 | 20 | 9

'IPO11 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.474 (Fisher's exact test), Q value = 0.75

Table S334. Gene #112: 'IPO11 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
IPO11 MUTATED | 2 | 3 | 1 | 0 | 1
IPO11 WILD-TYPE | 26 | 17 | 10 | 20 | 20

'IPO11 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0421 (Fisher's exact test), Q value = 0.42

Table S335. Gene #112: 'IPO11 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
IPO11 MUTATED | 4 | 0 | 3 | 0
IPO11 WILD-TYPE | 31 | 33 | 13 | 12

Figure S49. Get High-res Image Gene #112: 'IPO11 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'IPO11 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0317 (Fisher's exact test), Q value = 0.42

Table S336. Gene #112: 'IPO11 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
IPO11 MUTATED | 4 | 0 | 0 | 3 | 0 | 0 | 0
IPO11 WILD-TYPE | 30 | 11 | 9 | 4 | 6 | 20 | 9

Figure S50. Get High-res Image Gene #112: 'IPO11 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'FBXL3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.721 (Fisher's exact test), Q value = 0.88

Table S337. Gene #113: 'FBXL3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FBXL3 MUTATED | 1 | 1 | 0 | 0 | 2
FBXL3 WILD-TYPE | 27 | 19 | 11 | 20 | 19

'FBXL3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S338. Gene #113: 'FBXL3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FBXL3 MUTATED | 2 | 1 | 1 | 0
FBXL3 WILD-TYPE | 33 | 32 | 15 | 12

'FBXL3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.963 (Fisher's exact test), Q value = 1

Table S339. Gene #113: 'FBXL3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FBXL3 MUTATED | 3 | 0 | 0 | 0 | 0 | 1 | 0
FBXL3 WILD-TYPE | 31 | 11 | 9 | 7 | 6 | 19 | 9

'LNPEP MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0856 (Fisher's exact test), Q value = 0.47

Table S340. Gene #114: 'LNPEP MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LNPEP MUTATED | 1 | 4 | 0 | 1 | 0
LNPEP WILD-TYPE | 27 | 16 | 11 | 19 | 21

'LNPEP MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.541 (Fisher's exact test), Q value = 0.77

Table S341. Gene #114: 'LNPEP MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LNPEP MUTATED | 4 | 1 | 1 | 0
LNPEP WILD-TYPE | 31 | 32 | 15 | 12

'LNPEP MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.454 (Fisher's exact test), Q value = 0.73

Table S342. Gene #114: 'LNPEP MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LNPEP MUTATED | 3 | 0 | 1 | 1 | 0 | 0 | 1
LNPEP WILD-TYPE | 31 | 11 | 8 | 6 | 6 | 20 | 8

'LINGO4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.754 (Fisher's exact test), Q value = 0.9

Table S343. Gene #115: 'LINGO4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LINGO4 MUTATED | 1 | 1 | 1 | 1 | 0
LINGO4 WILD-TYPE | 27 | 19 | 10 | 19 | 21

'LINGO4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S344. Gene #115: 'LINGO4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LINGO4 MUTATED | 2 | 2 | 0 | 0
LINGO4 WILD-TYPE | 33 | 31 | 16 | 12

'LINGO4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.897 (Fisher's exact test), Q value = 0.97

Table S345. Gene #115: 'LINGO4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LINGO4 MUTATED | 2 | 0 | 0 | 0 | 0 | 1 | 1
LINGO4 WILD-TYPE | 32 | 11 | 9 | 7 | 6 | 19 | 8

'CPNE7 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S346. Gene #116: 'CPNE7 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CPNE7 MUTATED | 2 | 1 | 1 | 1 | 1
CPNE7 WILD-TYPE | 26 | 19 | 10 | 19 | 20

'CPNE7 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.174 (Fisher's exact test), Q value = 0.56

Table S347. Gene #116: 'CPNE7 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CPNE7 MUTATED | 4 | 0 | 1 | 1
CPNE7 WILD-TYPE | 31 | 33 | 15 | 11

'CPNE7 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.443 (Fisher's exact test), Q value = 0.72

Table S348. Gene #116: 'CPNE7 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CPNE7 MUTATED | 4 | 1 | 0 | 0 | 1 | 0 | 0
CPNE7 WILD-TYPE | 30 | 10 | 9 | 7 | 5 | 20 | 9

'DPCR1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S349. Gene #117: 'DPCR1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DPCR1 MUTATED | 3 | 2 | 1 | 2 | 2
DPCR1 WILD-TYPE | 25 | 18 | 10 | 18 | 19

'DPCR1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00934 (Fisher's exact test), Q value = 0.39

Table S350. Gene #117: 'DPCR1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DPCR1 MUTATED | 7 | 0 | 3 | 0
DPCR1 WILD-TYPE | 28 | 33 | 13 | 12

Figure S51. Get High-res Image Gene #117: 'DPCR1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'DPCR1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0521 (Fisher's exact test), Q value = 0.43

Table S351. Gene #117: 'DPCR1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DPCR1 MUTATED | 5 | 0 | 1 | 3 | 0 | 0 | 1
DPCR1 WILD-TYPE | 29 | 11 | 8 | 4 | 6 | 20 | 8

'SMTN MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.455 (Fisher's exact test), Q value = 0.73

Table S352. Gene #118: 'SMTN MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SMTN MUTATED | 2 | 4 | 0 | 1 | 2
SMTN WILD-TYPE | 26 | 16 | 11 | 19 | 19

'SMTN MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.231 (Fisher's exact test), Q value = 0.6

Table S353. Gene #118: 'SMTN MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SMTN MUTATED | 6 | 1 | 1 | 1
SMTN WILD-TYPE | 29 | 32 | 15 | 11

'SMTN MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.115 (Fisher's exact test), Q value = 0.48

Table S354. Gene #118: 'SMTN MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SMTN MUTATED | 7 | 0 | 0 | 0 | 1 | 0 | 1
SMTN WILD-TYPE | 27 | 11 | 9 | 7 | 5 | 20 | 8

'ATP2A1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.302 (Fisher's exact test), Q value = 0.65

Table S355. Gene #119: 'ATP2A1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ATP2A1 MUTATED | 1 | 0 | 0 | 2 | 3
ATP2A1 WILD-TYPE | 27 | 20 | 11 | 18 | 18

'ATP2A1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.239 (Fisher's exact test), Q value = 0.62

Table S356. Gene #119: 'ATP2A1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ATP2A1 MUTATED | 3 | 1 | 0 | 2
ATP2A1 WILD-TYPE | 32 | 32 | 16 | 10

'ATP2A1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.251 (Fisher's exact test), Q value = 0.63

Table S357. Gene #119: 'ATP2A1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ATP2A1 MUTATED | 3 | 0 | 0 | 0 | 2 | 1 | 0
ATP2A1 WILD-TYPE | 31 | 11 | 9 | 7 | 4 | 19 | 9

'PIGO MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.811 (Fisher's exact test), Q value = 0.93

Table S358. Gene #120: 'PIGO MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PIGO MUTATED | 1 | 2 | 1 | 1 | 2
PIGO WILD-TYPE | 27 | 18 | 10 | 19 | 19

'PIGO MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.406 (Fisher's exact test), Q value = 0.69

Table S359. Gene #120: 'PIGO MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PIGO MUTATED | 3 | 1 | 1 | 2
PIGO WILD-TYPE | 32 | 32 | 15 | 10

'PIGO MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.248 (Fisher's exact test), Q value = 0.63

Table S360. Gene #120: 'PIGO MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PIGO MUTATED | 4 | 0 | 0 | 0 | 2 | 1 | 0
PIGO WILD-TYPE | 30 | 11 | 9 | 7 | 4 | 19 | 9

'RRAS2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S361. Gene #121: 'RRAS2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RRAS2 MUTATED | 2 | 1 | 0 | 1 | 1
RRAS2 WILD-TYPE | 26 | 19 | 11 | 19 | 20

'RRAS2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.403 (Fisher's exact test), Q value = 0.69

Table S362. Gene #121: 'RRAS2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RRAS2 MUTATED | 1 | 2 | 2 | 0
RRAS2 WILD-TYPE | 34 | 31 | 14 | 12

'RRAS2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.679 (Fisher's exact test), Q value = 0.85

Table S363. Gene #121: 'RRAS2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RRAS2 MUTATED | 2 | 2 | 0 | 0 | 0 | 1 | 0
RRAS2 WILD-TYPE | 32 | 9 | 9 | 7 | 6 | 19 | 9

'DRD5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.816 (Fisher's exact test), Q value = 0.93

Table S364. Gene #122: 'DRD5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DRD5 MUTATED | 2 | 3 | 1 | 1 | 1
DRD5 WILD-TYPE | 26 | 17 | 10 | 19 | 20

'DRD5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.672 (Fisher's exact test), Q value = 0.85

Table S365. Gene #122: 'DRD5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DRD5 MUTATED | 2 | 3 | 1 | 2
DRD5 WILD-TYPE | 33 | 30 | 15 | 10

'DRD5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.411 (Fisher's exact test), Q value = 0.69

Table S366. Gene #122: 'DRD5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DRD5 MUTATED | 3 | 1 | 0 | 0 | 2 | 1 | 1
DRD5 WILD-TYPE | 31 | 10 | 9 | 7 | 4 | 19 | 8

'PRR25 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.258 (Fisher's exact test), Q value = 0.63

Table S367. Gene #123: 'PRR25 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PRR25 MUTATED | 1 | 3 | 0 | 1 | 0
PRR25 WILD-TYPE | 27 | 17 | 11 | 19 | 21

'PRR25 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.135 (Fisher's exact test), Q value = 0.51

Table S368. Gene #123: 'PRR25 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PRR25 MUTATED | 0 | 3 | 2 | 0
PRR25 WILD-TYPE | 35 | 30 | 14 | 12

'PRR25 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.229 (Fisher's exact test), Q value = 0.6

Table S369. Gene #123: 'PRR25 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PRR25 MUTATED | 1 | 0 | 0 | 1 | 0 | 1 | 2
PRR25 WILD-TYPE | 33 | 11 | 9 | 6 | 6 | 19 | 7

'PAX2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0913 (Fisher's exact test), Q value = 0.47

Table S370. Gene #124: 'PAX2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PAX2 MUTATED | 0 | 0 | 0 | 1 | 3
PAX2 WILD-TYPE | 28 | 20 | 11 | 19 | 18

'PAX2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00597 (Fisher's exact test), Q value = 0.32

Table S371. Gene #124: 'PAX2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PAX2 MUTATED | 0 | 1 | 0 | 3
PAX2 WILD-TYPE | 35 | 32 | 16 | 9

Figure S52. Get High-res Image Gene #124: 'PAX2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'PAX2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.127 (Fisher's exact test), Q value = 0.5

Table S372. Gene #124: 'PAX2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PAX2 MUTATED | 1 | 0 | 0 | 0 | 2 | 1 | 0
PAX2 WILD-TYPE | 33 | 11 | 9 | 7 | 4 | 19 | 9

'KIF24 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0926 (Fisher's exact test), Q value = 0.47

Table S373. Gene #125: 'KIF24 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KIF24 MUTATED | 0 | 0 | 0 | 1 | 3
KIF24 WILD-TYPE | 28 | 20 | 11 | 19 | 18

'KIF24 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.719 (Fisher's exact test), Q value = 0.88

Table S374. Gene #125: 'KIF24 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KIF24 MUTATED | 2 | 1 | 0 | 1
KIF24 WILD-TYPE | 33 | 32 | 16 | 11

'KIF24 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.962 (Fisher's exact test), Q value = 1

Table S375. Gene #125: 'KIF24 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KIF24 MUTATED | 3 | 0 | 0 | 0 | 0 | 1 | 0
KIF24 WILD-TYPE | 31 | 11 | 9 | 7 | 6 | 19 | 9

'NOS3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.486 (Fisher's exact test), Q value = 0.75

Table S376. Gene #126: 'NOS3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NOS3 MUTATED | 2 | 1 | 1 | 0 | 3
NOS3 WILD-TYPE | 26 | 19 | 10 | 20 | 18

'NOS3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0411 (Fisher's exact test), Q value = 0.42

Table S377. Gene #126: 'NOS3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NOS3 MUTATED | 4 | 0 | 3 | 0
NOS3 WILD-TYPE | 31 | 33 | 13 | 12

Figure S53. Get High-res Image Gene #126: 'NOS3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'NOS3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.174 (Fisher's exact test), Q value = 0.56

Table S378. Gene #126: 'NOS3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NOS3 MUTATED | 6 | 0 | 0 | 1 | 0 | 0 | 0
NOS3 WILD-TYPE | 28 | 11 | 9 | 6 | 6 | 20 | 9

'ANAPC1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.055 (Fisher's exact test), Q value = 0.43

Table S379. Gene #127: 'ANAPC1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ANAPC1 MUTATED | 1 | 0 | 3 | 1 | 1
ANAPC1 WILD-TYPE | 27 | 20 | 8 | 19 | 20

'ANAPC1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.112 (Fisher's exact test), Q value = 0.48

Table S380. Gene #127: 'ANAPC1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ANAPC1 MUTATED | 3 | 0 | 1 | 2
ANAPC1 WILD-TYPE | 32 | 33 | 15 | 10

'ANAPC1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.275 (Fisher's exact test), Q value = 0.63

Table S381. Gene #127: 'ANAPC1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ANAPC1 MUTATED | 4 | 0 | 0 | 1 | 1 | 0 | 0
ANAPC1 WILD-TYPE | 30 | 11 | 9 | 6 | 5 | 20 | 9

'DNHD1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.301 (Fisher's exact test), Q value = 0.65

Table S382. Gene #128: 'DNHD1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DNHD1 MUTATED | 4 | 5 | 1 | 5 | 1
DNHD1 WILD-TYPE | 24 | 15 | 10 | 15 | 20

'DNHD1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0181 (Fisher's exact test), Q value = 0.4

Table S383. Gene #128: 'DNHD1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DNHD1 MUTATED | 9 | 2 | 5 | 0
DNHD1 WILD-TYPE | 26 | 31 | 11 | 12

Figure S54. Get High-res Image Gene #128: 'DNHD1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'DNHD1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.452 (Fisher's exact test), Q value = 0.73

Table S384. Gene #128: 'DNHD1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DNHD1 MUTATED | 7 | 1 | 1 | 3 | 0 | 2 | 2
DNHD1 WILD-TYPE | 27 | 10 | 8 | 4 | 6 | 18 | 7

'IL27 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0019 (Fisher's exact test), Q value = 0.25

Table S385. Gene #129: 'IL27 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
IL27 MUTATED | 0 | 1 | 3 | 0 | 0
IL27 WILD-TYPE | 28 | 19 | 8 | 20 | 21

Figure S55. Get High-res Image Gene #129: 'IL27 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

'IL27 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.809 (Fisher's exact test), Q value = 0.93

Table S386. Gene #129: 'IL27 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
IL27 MUTATED | 1 | 2 | 1 | 0
IL27 WILD-TYPE | 34 | 31 | 15 | 12

'IL27 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.172 (Fisher's exact test), Q value = 0.56

Table S387. Gene #129: 'IL27 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
IL27 MUTATED | 0 | 0 | 1 | 1 | 0 | 2 | 0
IL27 WILD-TYPE | 34 | 11 | 8 | 6 | 6 | 18 | 9

'RYR2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.256 (Fisher's exact test), Q value = 0.63

Table S388. Gene #130: 'RYR2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RYR2 MUTATED | 6 | 6 | 3 | 1 | 3
RYR2 WILD-TYPE | 22 | 14 | 8 | 19 | 18

'RYR2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00044 (Fisher's exact test), Q value = 0.25

Table S389. Gene #130: 'RYR2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RYR2 MUTATED | 12 | 0 | 5 | 2
RYR2 WILD-TYPE | 23 | 33 | 11 | 10

Figure S56. Get High-res Image Gene #130: 'RYR2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'RYR2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.00816 (Fisher's exact test), Q value = 0.39

Table S390. Gene #130: 'RYR2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RYR2 MUTATED | 11 | 1 | 2 | 3 | 2 | 0 | 0
RYR2 WILD-TYPE | 23 | 10 | 7 | 4 | 4 | 20 | 9

Figure S57. Get High-res Image Gene #130: 'RYR2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'CHPF2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0558 (Fisher's exact test), Q value = 0.43

Table S391. Gene #131: 'CHPF2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CHPF2 MUTATED | 0 | 4 | 0 | 1 | 3
CHPF2 WILD-TYPE | 28 | 16 | 11 | 19 | 18

'CHPF2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.366 (Fisher's exact test), Q value = 0.68

Table S392. Gene #131: 'CHPF2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CHPF2 MUTATED | 4 | 1 | 1 | 2
CHPF2 WILD-TYPE | 31 | 32 | 15 | 10

'CHPF2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0641 (Fisher's exact test), Q value = 0.45

Table S393. Gene #131: 'CHPF2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CHPF2 MUTATED | 3 | 0 | 0 | 1 | 2 | 0 | 2
CHPF2 WILD-TYPE | 31 | 11 | 9 | 6 | 4 | 20 | 7

'TNK2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.614 (Fisher's exact test), Q value = 0.82

Table S394. Gene #132: 'TNK2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TNK2 MUTATED | 2 | 1 | 2 | 1 | 3
TNK2 WILD-TYPE | 26 | 19 | 9 | 19 | 18

'TNK2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0271 (Fisher's exact test), Q value = 0.42

Table S395. Gene #132: 'TNK2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TNK2 MUTATED | 2 | 2 | 5 | 0
TNK2 WILD-TYPE | 33 | 31 | 11 | 12

Figure S58. Get High-res Image Gene #132: 'TNK2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'TNK2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.366 (Fisher's exact test), Q value = 0.68

Table S396. Gene #132: 'TNK2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TNK2 MUTATED | 5 | 0 | 0 | 2 | 0 | 1 | 1
TNK2 WILD-TYPE | 29 | 11 | 9 | 5 | 6 | 19 | 8

'PPP2R1A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.834 (Fisher's exact test), Q value = 0.94

Table S397. Gene #133: 'PPP2R1A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PPP2R1A MUTATED | 3 | 2 | 0 | 3 | 2
PPP2R1A WILD-TYPE | 25 | 18 | 11 | 17 | 19

'PPP2R1A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S398. Gene #133: 'PPP2R1A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PPP2R1A MUTATED | 4 | 4 | 1 | 1
PPP2R1A WILD-TYPE | 31 | 29 | 15 | 11

'PPP2R1A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.679 (Fisher's exact test), Q value = 0.85

Table S399. Gene #133: 'PPP2R1A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PPP2R1A MUTATED | 3 | 1 | 0 | 0 | 1 | 3 | 2
PPP2R1A WILD-TYPE | 31 | 10 | 9 | 7 | 5 | 17 | 7

'KBTBD10 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.454 (Fisher's exact test), Q value = 0.73

Table S400. Gene #134: 'KBTBD10 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KBTBD10 MUTATED | 2 | 1 | 0 | 0 | 3
KBTBD10 WILD-TYPE | 26 | 19 | 11 | 20 | 18

'KBTBD10 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.539 (Fisher's exact test), Q value = 0.77

Table S401. Gene #134: 'KBTBD10 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KBTBD10 MUTATED | 4 | 2 | 0 | 0
KBTBD10 WILD-TYPE | 31 | 31 | 16 | 12

'KBTBD10 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.248 (Fisher's exact test), Q value = 0.63

Table S402. Gene #134: 'KBTBD10 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KBTBD10 MUTATED | 4 | 0 | 0 | 0 | 0 | 0 | 2
KBTBD10 WILD-TYPE | 30 | 11 | 9 | 7 | 6 | 20 | 7

'ERMP1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.832 (Fisher's exact test), Q value = 0.94

Table S403. Gene #135: 'ERMP1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ERMP1 MUTATED | 2 | 1 | 1 | 0 | 1
ERMP1 WILD-TYPE | 26 | 19 | 10 | 20 | 20

'ERMP1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.267 (Fisher's exact test), Q value = 0.63

Table S404. Gene #135: 'ERMP1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ERMP1 MUTATED | 3 | 0 | 1 | 1
ERMP1 WILD-TYPE | 32 | 33 | 15 | 11

'ERMP1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.354 (Fisher's exact test), Q value = 0.68

Table S405. Gene #135: 'ERMP1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ERMP1 MUTATED | 4 | 0 | 0 | 0 | 1 | 0 | 0
ERMP1 WILD-TYPE | 30 | 11 | 9 | 7 | 5 | 20 | 9

'DAB2IP MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.24 (Fisher's exact test), Q value = 0.62

Table S406. Gene #136: 'DAB2IP MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DAB2IP MUTATED | 3 | 1 | 0 | 1 | 5
DAB2IP WILD-TYPE | 25 | 19 | 11 | 19 | 16

'DAB2IP MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.35 (Fisher's exact test), Q value = 0.68

Table S407. Gene #136: 'DAB2IP MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DAB2IP MUTATED | 4 | 1 | 2 | 2
DAB2IP WILD-TYPE | 31 | 32 | 14 | 10

'DAB2IP MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0731 (Fisher's exact test), Q value = 0.47

Table S408. Gene #136: 'DAB2IP MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DAB2IP MUTATED | 6 | 0 | 0 | 0 | 2 | 0 | 1
DAB2IP WILD-TYPE | 28 | 11 | 9 | 7 | 4 | 20 | 8

'BCOR MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.836 (Fisher's exact test), Q value = 0.94

Table S409. Gene #137: 'BCOR MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
BCOR MUTATED | 2 | 3 | 2 | 2 | 2
BCOR WILD-TYPE | 26 | 17 | 9 | 18 | 19

'BCOR MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0119 (Fisher's exact test), Q value = 0.39

Table S410. Gene #137: 'BCOR MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
BCOR MUTATED | 9 | 1 | 0 | 1
BCOR WILD-TYPE | 26 | 32 | 16 | 11

Figure S59. Get High-res Image Gene #137: 'BCOR MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'BCOR MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0422 (Fisher's exact test), Q value = 0.42

Table S411. Gene #137: 'BCOR MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
BCOR MUTATED | 9 | 1 | 0 | 0 | 1 | 0 | 0
BCOR WILD-TYPE | 25 | 10 | 9 | 7 | 5 | 20 | 9

Figure S60. Get High-res Image Gene #137: 'BCOR MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'C22ORF28 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.492 (Fisher's exact test), Q value = 0.75

Table S412. Gene #138: 'C22ORF28 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C22ORF28 MUTATED | 1 | 0 | 0 | 2 | 2
C22ORF28 WILD-TYPE | 27 | 20 | 11 | 18 | 19

'C22ORF28 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.52 (Fisher's exact test), Q value = 0.76

Table S413. Gene #138: 'C22ORF28 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C22ORF28 MUTATED | 3 | 1 | 0 | 1
C22ORF28 WILD-TYPE | 32 | 32 | 16 | 11

'C22ORF28 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.756 (Fisher's exact test), Q value = 0.9

Table S414. Gene #138: 'C22ORF28 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C22ORF28 MUTATED | 3 | 0 | 0 | 0 | 1 | 1 | 0
C22ORF28 WILD-TYPE | 31 | 11 | 9 | 7 | 5 | 19 | 9

'LHX1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.741 (Fisher's exact test), Q value = 0.89

Table S415. Gene #139: 'LHX1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LHX1 MUTATED | 3 | 1 | 0 | 1 | 3
LHX1 WILD-TYPE | 25 | 19 | 11 | 19 | 18

'LHX1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.365 (Fisher's exact test), Q value = 0.68

Table S416. Gene #139: 'LHX1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LHX1 MUTATED | 4 | 1 | 1 | 2
LHX1 WILD-TYPE | 31 | 32 | 15 | 10

'LHX1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.262 (Fisher's exact test), Q value = 0.63

Table S417. Gene #139: 'LHX1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LHX1 MUTATED | 5 | 0 | 0 | 1 | 1 | 0 | 1
LHX1 WILD-TYPE | 29 | 11 | 9 | 6 | 5 | 20 | 8

'USP26 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.452 (Fisher's exact test), Q value = 0.73

Table S418. Gene #140: 'USP26 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
USP26 MUTATED | 2 | 4 | 0 | 1 | 2
USP26 WILD-TYPE | 26 | 16 | 11 | 19 | 19

'USP26 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.739 (Fisher's exact test), Q value = 0.89

Table S419. Gene #140: 'USP26 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
USP26 MUTATED | 5 | 2 | 1 | 1
USP26 WILD-TYPE | 30 | 31 | 15 | 11

'USP26 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.347 (Fisher's exact test), Q value = 0.68

Table S420. Gene #140: 'USP26 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
USP26 MUTATED | 4 | 1 | 1 | 0 | 1 | 0 | 2
USP26 WILD-TYPE | 30 | 10 | 8 | 7 | 5 | 20 | 7

'RBM27 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0851 (Fisher's exact test), Q value = 0.47

Table S421. Gene #141: 'RBM27 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RBM27 MUTATED | 3 | 5 | 0 | 0 | 3
RBM27 WILD-TYPE | 25 | 15 | 11 | 20 | 18

'RBM27 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.556 (Fisher's exact test), Q value = 0.78

Table S422. Gene #141: 'RBM27 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RBM27 MUTATED | 5 | 2 | 3 | 1
RBM27 WILD-TYPE | 30 | 31 | 13 | 11

'RBM27 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.292 (Fisher's exact test), Q value = 0.64

Table S423. Gene #141: 'RBM27 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RBM27 MUTATED | 6 | 0 | 0 | 2 | 1 | 1 | 1
RBM27 WILD-TYPE | 28 | 11 | 9 | 5 | 5 | 19 | 8

'CCDC43 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.639 (Fisher's exact test), Q value = 0.84

Table S424. Gene #142: 'CCDC43 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CCDC43 MUTATED | 1 | 1 | 1 | 3 | 1
CCDC43 WILD-TYPE | 27 | 19 | 10 | 17 | 20

'CCDC43 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.55 (Fisher's exact test), Q value = 0.77

Table S425. Gene #142: 'CCDC43 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CCDC43 MUTATED | 3 | 1 | 2 | 1
CCDC43 WILD-TYPE | 32 | 32 | 14 | 11

'CCDC43 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.278 (Fisher's exact test), Q value = 0.63

Table S426. Gene #142: 'CCDC43 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CCDC43 MUTATED | 3 | 0 | 0 | 2 | 1 | 1 | 0
CCDC43 WILD-TYPE | 31 | 11 | 9 | 5 | 5 | 19 | 9

'LIN54 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.504 (Fisher's exact test), Q value = 0.75

Table S427. Gene #143: 'LIN54 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LIN54 MUTATED | 0 | 1 | 0 | 1 | 2
LIN54 WILD-TYPE | 28 | 19 | 11 | 19 | 19

'LIN54 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.319 (Fisher's exact test), Q value = 0.65

Table S428. Gene #143: 'LIN54 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LIN54 MUTATED | 3 | 0 | 1 | 0
LIN54 WILD-TYPE | 32 | 33 | 15 | 12

'LIN54 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.482 (Fisher's exact test), Q value = 0.75

Table S429. Gene #143: 'LIN54 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LIN54 MUTATED | 3 | 0 | 0 | 1 | 0 | 0 | 0
LIN54 WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 20 | 9

'FAM8A1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.315 (Fisher's exact test), Q value = 0.65

Table S430. Gene #144: 'FAM8A1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FAM8A1 MUTATED | 1 | 3 | 1 | 0 | 1
FAM8A1 WILD-TYPE | 27 | 17 | 10 | 20 | 20

'FAM8A1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.569 (Fisher's exact test), Q value = 0.78

Table S431. Gene #144: 'FAM8A1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FAM8A1 MUTATED | 2 | 1 | 2 | 1
FAM8A1 WILD-TYPE | 33 | 32 | 14 | 11

'FAM8A1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.405 (Fisher's exact test), Q value = 0.69

Table S432. Gene #144: 'FAM8A1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FAM8A1 MUTATED | 1 | 1 | 1 | 1 | 1 | 1 | 0
FAM8A1 WILD-TYPE | 33 | 10 | 8 | 6 | 5 | 19 | 9

'ZDHHC8 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.255 (Fisher's exact test), Q value = 0.63

Table S433. Gene #145: 'ZDHHC8 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZDHHC8 MUTATED | 1 | 1 | 2 | 0 | 2
ZDHHC8 WILD-TYPE | 27 | 19 | 9 | 20 | 19

'ZDHHC8 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.542 (Fisher's exact test), Q value = 0.77

Table S434. Gene #145: 'ZDHHC8 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZDHHC8 MUTATED | 4 | 1 | 1 | 0
ZDHHC8 WILD-TYPE | 31 | 32 | 15 | 12

'ZDHHC8 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.413 (Fisher's exact test), Q value = 0.69

Table S435. Gene #145: 'ZDHHC8 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZDHHC8 MUTATED | 4 | 0 | 0 | 1 | 0 | 0 | 1
ZDHHC8 WILD-TYPE | 30 | 11 | 9 | 6 | 6 | 20 | 8

'PHKG2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0937 (Fisher's exact test), Q value = 0.47

Table S436. Gene #146: 'PHKG2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PHKG2 MUTATED | 0 | 0 | 0 | 1 | 3
PHKG2 WILD-TYPE | 28 | 20 | 11 | 19 | 18

'PHKG2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0652 (Fisher's exact test), Q value = 0.45

Table S437. Gene #146: 'PHKG2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PHKG2 MUTATED | 2 | 0 | 0 | 2
PHKG2 WILD-TYPE | 33 | 33 | 16 | 10

'PHKG2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.105 (Fisher's exact test), Q value = 0.48

Table S438. Gene #146: 'PHKG2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PHKG2 MUTATED | 2 | 0 | 0 | 0 | 2 | 0 | 0
PHKG2 WILD-TYPE | 32 | 11 | 9 | 7 | 4 | 20 | 9

'POLE MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.904 (Fisher's exact test), Q value = 0.97

Table S439. Gene #147: 'POLE MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
POLE MUTATED | 2 | 3 | 1 | 1 | 2
POLE WILD-TYPE | 26 | 17 | 10 | 19 | 19

'POLE MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0821 (Fisher's exact test), Q value = 0.47

Table S440. Gene #147: 'POLE MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
POLE MUTATED | 7 | 1 | 1 | 0
POLE WILD-TYPE | 28 | 32 | 15 | 12

'POLE MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.515 (Fisher's exact test), Q value = 0.76

Table S441. Gene #147: 'POLE MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
POLE MUTATED | 6 | 0 | 1 | 1 | 0 | 1 | 0
POLE WILD-TYPE | 28 | 11 | 8 | 6 | 6 | 19 | 9

'TCERG1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.568 (Fisher's exact test), Q value = 0.78

Table S442. Gene #148: 'TCERG1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TCERG1 MUTATED | 1 | 3 | 1 | 1 | 3
TCERG1 WILD-TYPE | 27 | 17 | 10 | 19 | 18

'TCERG1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00523 (Fisher's exact test), Q value = 0.32

Table S443. Gene #148: 'TCERG1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TCERG1 MUTATED | 3 | 0 | 5 | 1
TCERG1 WILD-TYPE | 32 | 33 | 11 | 11

Figure S61. Get High-res Image Gene #148: 'TCERG1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'TCERG1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0256 (Fisher's exact test), Q value = 0.42

Table S444. Gene #148: 'TCERG1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TCERG1 MUTATED | 5 | 0 | 0 | 3 | 1 | 0 | 0
TCERG1 WILD-TYPE | 29 | 11 | 9 | 4 | 5 | 20 | 9

Figure S62. Get High-res Image Gene #148: 'TCERG1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'TTLL10 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0933 (Fisher's exact test), Q value = 0.47

Table S445. Gene #149: 'TTLL10 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TTLL10 MUTATED | 0 | 1 | 0 | 0 | 3
TTLL10 WILD-TYPE | 28 | 19 | 11 | 20 | 18

'TTLL10 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.354 (Fisher's exact test), Q value = 0.68

Table S446. Gene #149: 'TTLL10 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TTLL10 MUTATED | 2 | 0 | 1 | 1
TTLL10 WILD-TYPE | 33 | 33 | 15 | 11

'TTLL10 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.4 (Fisher's exact test), Q value = 0.69

Table S447. Gene #149: 'TTLL10 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TTLL10 MUTATED | 3 | 0 | 0 | 0 | 1 | 0 | 0
TTLL10 WILD-TYPE | 31 | 11 | 9 | 7 | 5 | 20 | 9

'EBPL MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.123 (Fisher's exact test), Q value = 0.49

Table S448. Gene #150: 'EBPL MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
EBPL MUTATED | 1 | 0 | 0 | 3 | 0
EBPL WILD-TYPE | 27 | 20 | 11 | 17 | 21

'EBPL MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.184 (Fisher's exact test), Q value = 0.56

Table S449. Gene #150: 'EBPL MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
EBPL MUTATED | 2 | 0 | 2 | 0
EBPL WILD-TYPE | 33 | 33 | 14 | 12

'EBPL MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.483 (Fisher's exact test), Q value = 0.75

Table S450. Gene #150: 'EBPL MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
EBPL MUTATED | 3 | 0 | 0 | 1 | 0 | 0 | 0
EBPL WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 20 | 9

'NOSTRIN MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.755 (Fisher's exact test), Q value = 0.9

Table S451. Gene #151: 'NOSTRIN MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NOSTRIN MUTATED | 1 | 1 | 1 | 1 | 0
NOSTRIN WILD-TYPE | 27 | 19 | 10 | 19 | 21

'NOSTRIN MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.381 (Fisher's exact test), Q value = 0.68

Table S452. Gene #151: 'NOSTRIN MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NOSTRIN MUTATED | 2 | 0 | 0 | 1
NOSTRIN WILD-TYPE | 33 | 33 | 16 | 11

'NOSTRIN MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.285 (Fisher's exact test), Q value = 0.64

Table S453. Gene #151: 'NOSTRIN MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NOSTRIN MUTATED | 1 | 0 | 0 | 0 | 1 | 0 | 1
NOSTRIN WILD-TYPE | 33 | 11 | 9 | 7 | 5 | 20 | 8

'DAZAP1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.397 (Fisher's exact test), Q value = 0.69

Table S454. Gene #152: 'DAZAP1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DAZAP1 MUTATED | 3 | 1 | 0 | 0 | 3
DAZAP1 WILD-TYPE | 25 | 19 | 11 | 20 | 18

'DAZAP1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.168 (Fisher's exact test), Q value = 0.56

Table S455. Gene #152: 'DAZAP1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DAZAP1 MUTATED | 3 | 0 | 2 | 1
DAZAP1 WILD-TYPE | 32 | 33 | 14 | 11

'DAZAP1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.274 (Fisher's exact test), Q value = 0.63

Table S456. Gene #152: 'DAZAP1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DAZAP1 MUTATED | 4 | 0 | 0 | 1 | 1 | 0 | 0
DAZAP1 WILD-TYPE | 30 | 11 | 9 | 6 | 5 | 20 | 9

'C6ORF10 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.551 (Fisher's exact test), Q value = 0.77

Table S457. Gene #153: 'C6ORF10 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C6ORF10 MUTATED | 1 | 1 | 1 | 0 | 0
C6ORF10 WILD-TYPE | 27 | 19 | 10 | 20 | 21

'C6ORF10 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.864 (Fisher's exact test), Q value = 0.94

Table S458. Gene #153: 'C6ORF10 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C6ORF10 MUTATED | 1 | 1 | 1 | 0
C6ORF10 WILD-TYPE | 34 | 32 | 15 | 12

'C6ORF10 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.367 (Fisher's exact test), Q value = 0.68

Table S459. Gene #153: 'C6ORF10 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C6ORF10 MUTATED | 1 | 0 | 0 | 1 | 0 | 0 | 1
C6ORF10 WILD-TYPE | 33 | 11 | 9 | 6 | 6 | 20 | 8

'C19ORF2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.649 (Fisher's exact test), Q value = 0.84

Table S460. Gene #154: 'C19ORF2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C19ORF2 MUTATED | 1 | 2 | 1 | 1 | 3
C19ORF2 WILD-TYPE | 27 | 18 | 10 | 19 | 18

'C19ORF2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0843 (Fisher's exact test), Q value = 0.47

Table S461. Gene #154: 'C19ORF2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C19ORF2 MUTATED | 5 | 0 | 2 | 1
C19ORF2 WILD-TYPE | 30 | 33 | 14 | 11

'C19ORF2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.213 (Fisher's exact test), Q value = 0.58

Table S462. Gene #154: 'C19ORF2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C19ORF2 MUTATED | 6 | 0 | 0 | 1 | 0 | 0 | 1
C19ORF2 WILD-TYPE | 28 | 11 | 9 | 6 | 6 | 20 | 8

'HOXA11 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.958 (Fisher's exact test), Q value = 1

Table S463. Gene #155: 'HOXA11 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
HOXA11 MUTATED | 1 | 1 | 1 | 1 | 1
HOXA11 WILD-TYPE | 27 | 19 | 10 | 19 | 20

'HOXA11 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.352 (Fisher's exact test), Q value = 0.68

Table S464. Gene #155: 'HOXA11 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
HOXA11 MUTATED | 2 | 0 | 1 | 1
HOXA11 WILD-TYPE | 33 | 33 | 15 | 11

'HOXA11 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.309 (Fisher's exact test), Q value = 0.65

Table S465. Gene #155: 'HOXA11 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
HOXA11 MUTATED | 2 | 0 | 0 | 1 | 1 | 0 | 0
HOXA11 WILD-TYPE | 32 | 11 | 9 | 6 | 5 | 20 | 9

'ZRSR2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.452 (Fisher's exact test), Q value = 0.73

Table S466. Gene #156: 'ZRSR2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZRSR2 MUTATED | 2 | 1 | 0 | 0 | 3
ZRSR2 WILD-TYPE | 26 | 19 | 11 | 20 | 18

'ZRSR2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.176 (Fisher's exact test), Q value = 0.56

Table S467. Gene #156: 'ZRSR2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZRSR2 MUTATED | 4 | 0 | 1 | 1
ZRSR2 WILD-TYPE | 31 | 33 | 15 | 11

'ZRSR2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.276 (Fisher's exact test), Q value = 0.63

Table S468. Gene #156: 'ZRSR2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZRSR2 MUTATED | 4 | 0 | 0 | 1 | 1 | 0 | 0
ZRSR2 WILD-TYPE | 30 | 11 | 9 | 6 | 5 | 20 | 9

'NR4A2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0151 (Fisher's exact test), Q value = 0.39

Table S469. Gene #157: 'NR4A2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NR4A2 MUTATED | 0 | 4 | 0 | 0 | 2
NR4A2 WILD-TYPE | 28 | 16 | 11 | 20 | 19

Figure S63. Get High-res Image Gene #157: 'NR4A2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

'NR4A2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.819 (Fisher's exact test), Q value = 0.93

Table S470. Gene #157: 'NR4A2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NR4A2 MUTATED | 3 | 1 | 1 | 1
NR4A2 WILD-TYPE | 32 | 32 | 15 | 11

'NR4A2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.368 (Fisher's exact test), Q value = 0.68

Table S471. Gene #157: 'NR4A2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NR4A2 MUTATED | 4 | 0 | 0 | 0 | 1 | 0 | 1
NR4A2 WILD-TYPE | 30 | 11 | 9 | 7 | 5 | 20 | 8

'COIL MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.406 (Fisher's exact test), Q value = 0.69

Table S472. Gene #158: 'COIL MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
COIL MUTATED | 2 | 0 | 2 | 1 | 1
COIL WILD-TYPE | 26 | 20 | 9 | 19 | 20

'COIL MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.447 (Fisher's exact test), Q value = 0.73

Table S473. Gene #158: 'COIL MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
COIL MUTATED | 3 | 1 | 2 | 0
COIL WILD-TYPE | 32 | 32 | 14 | 12

'COIL MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.372 (Fisher's exact test), Q value = 0.68

Table S474. Gene #158: 'COIL MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
COIL MUTATED | 3 | 0 | 0 | 2 | 0 | 1 | 0
COIL WILD-TYPE | 31 | 11 | 9 | 5 | 6 | 19 | 9

'CDS1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.957 (Fisher's exact test), Q value = 1

Table S475. Gene #159: 'CDS1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CDS1 MUTATED | 1 | 1 | 1 | 1 | 1
CDS1 WILD-TYPE | 27 | 19 | 10 | 19 | 20

'CDS1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.266 (Fisher's exact test), Q value = 0.63

Table S476. Gene #159: 'CDS1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CDS1 MUTATED | 3 | 0 | 1 | 1
CDS1 WILD-TYPE | 32 | 33 | 15 | 11

'CDS1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.297 (Fisher's exact test), Q value = 0.65

Table S477. Gene #159: 'CDS1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CDS1 MUTATED | 3 | 0 | 0 | 1 | 1 | 0 | 0
CDS1 WILD-TYPE | 31 | 11 | 9 | 6 | 5 | 20 | 9

'MTMR9 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.278 (Fisher's exact test), Q value = 0.63

Table S478. Gene #160: 'MTMR9 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MTMR9 MUTATED | 1 | 2 | 1 | 0 | 0
MTMR9 WILD-TYPE | 27 | 18 | 10 | 20 | 21

'MTMR9 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.257 (Fisher's exact test), Q value = 0.63

Table S479. Gene #160: 'MTMR9 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MTMR9 MUTATED | 0 | 3 | 1 | 0
MTMR9 WILD-TYPE | 35 | 30 | 15 | 12

'MTMR9 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.79 (Fisher's exact test), Q value = 0.92

Table S480. Gene #160: 'MTMR9 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MTMR9 MUTATED | 1 | 1 | 0 | 0 | 0 | 1 | 1
MTMR9 WILD-TYPE | 33 | 10 | 9 | 7 | 6 | 19 | 8

'LRP2BP MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0215 (Fisher's exact test), Q value = 0.4

Table S481. Gene #161: 'LRP2BP MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LRP2BP MUTATED | 0 | 4 | 0 | 0 | 1
LRP2BP WILD-TYPE | 28 | 16 | 11 | 20 | 20

Figure S64. Get High-res Image Gene #161: 'LRP2BP MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

'LRP2BP MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.176 (Fisher's exact test), Q value = 0.56

Table S482. Gene #161: 'LRP2BP MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LRP2BP MUTATED | 4 | 0 | 1 | 0
LRP2BP WILD-TYPE | 31 | 33 | 15 | 12

'LRP2BP MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.362 (Fisher's exact test), Q value = 0.68

Table S483. Gene #161: 'LRP2BP MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LRP2BP MUTATED | 2 | 0 | 1 | 1 | 0 | 0 | 1
LRP2BP WILD-TYPE | 32 | 11 | 8 | 6 | 6 | 20 | 8

'REPIN1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.844 (Fisher's exact test), Q value = 0.94

Table S484. Gene #162: 'REPIN1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
REPIN1 MUTATED | 3 | 2 | 0 | 1 | 1
REPIN1 WILD-TYPE | 25 | 18 | 11 | 19 | 20

'REPIN1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0228 (Fisher's exact test), Q value = 0.4

Table S485. Gene #162: 'REPIN1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
REPIN1 MUTATED | 6 | 0 | 0 | 1
REPIN1 WILD-TYPE | 29 | 33 | 16 | 11

Figure S65. Get High-res Image Gene #162: 'REPIN1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'REPIN1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.389 (Fisher's exact test), Q value = 0.68

Table S486. Gene #162: 'REPIN1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
REPIN1 MUTATED | 5 | 0 | 1 | 0 | 0 | 0 | 1
REPIN1 WILD-TYPE | 29 | 11 | 8 | 7 | 6 | 20 | 8

'DHX57 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.333 (Fisher's exact test), Q value = 0.67

Table S487. Gene #163: 'DHX57 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DHX57 MUTATED | 2 | 2 | 3 | 1 | 1
DHX57 WILD-TYPE | 26 | 18 | 8 | 19 | 20

'DHX57 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.663 (Fisher's exact test), Q value = 0.85

Table S488. Gene #163: 'DHX57 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DHX57 MUTATED | 5 | 3 | 1 | 0
DHX57 WILD-TYPE | 30 | 30 | 15 | 12

'DHX57 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.849 (Fisher's exact test), Q value = 0.94

Table S489. Gene #163: 'DHX57 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DHX57 MUTATED | 5 | 1 | 0 | 1 | 0 | 1 | 1
DHX57 WILD-TYPE | 29 | 10 | 9 | 6 | 6 | 19 | 8

'FHOD3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.132 (Fisher's exact test), Q value = 0.51

Table S490. Gene #164: 'FHOD3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FHOD3 MUTATED | 1 | 3 | 1 | 0 | 4
FHOD3 WILD-TYPE | 27 | 17 | 10 | 20 | 17

'FHOD3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0434 (Fisher's exact test), Q value = 0.42

Table S491. Gene #164: 'FHOD3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FHOD3 MUTATED | 4 | 0 | 3 | 2
FHOD3 WILD-TYPE | 31 | 33 | 13 | 10

Figure S66. Get High-res Image Gene #164: 'FHOD3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'FHOD3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0534 (Fisher's exact test), Q value = 0.43

Table S492. Gene #164: 'FHOD3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FHOD3 MUTATED | 4 | 0 | 1 | 2 | 2 | 0 | 0
FHOD3 WILD-TYPE | 30 | 11 | 8 | 5 | 4 | 20 | 9

'SLC25A24 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0381 (Fisher's exact test), Q value = 0.42

Table S493. Gene #165: 'SLC25A24 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SLC25A24 MUTATED | 0 | 2 | 2 | 1 | 0
SLC25A24 WILD-TYPE | 28 | 18 | 9 | 19 | 21

Figure S67. Get High-res Image Gene #165: 'SLC25A24 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

'SLC25A24 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.187 (Fisher's exact test), Q value = 0.56

Table S494. Gene #165: 'SLC25A24 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SLC25A24 MUTATED | 2 | 0 | 2 | 1
SLC25A24 WILD-TYPE | 33 | 33 | 14 | 11

'SLC25A24 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.298 (Fisher's exact test), Q value = 0.65

Table S495. Gene #165: 'SLC25A24 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SLC25A24 MUTATED | 3 | 0 | 0 | 1 | 1 | 0 | 0
SLC25A24 WILD-TYPE | 31 | 11 | 9 | 6 | 5 | 20 | 9

'PPRC1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.442 (Fisher's exact test), Q value = 0.72

Table S496. Gene #166: 'PPRC1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PPRC1 MUTATED | 0 | 2 | 0 | 1 | 1
PPRC1 WILD-TYPE | 28 | 18 | 11 | 19 | 20

'PPRC1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.653 (Fisher's exact test), Q value = 0.84

Table S497. Gene #166: 'PPRC1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PPRC1 MUTATED | 1 | 1 | 1 | 1
PPRC1 WILD-TYPE | 34 | 32 | 15 | 11

'PPRC1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.188 (Fisher's exact test), Q value = 0.56

Table S498. Gene #166: 'PPRC1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PPRC1 MUTATED | 1 | 0 | 0 | 1 | 1 | 0 | 1
PPRC1 WILD-TYPE | 33 | 11 | 9 | 6 | 5 | 20 | 8

'ZMYM3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.256 (Fisher's exact test), Q value = 0.63

Table S499. Gene #167: 'ZMYM3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZMYM3 MUTATED | 2 | 3 | 1 | 0 | 4
ZMYM3 WILD-TYPE | 26 | 17 | 10 | 20 | 17

'ZMYM3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.104 (Fisher's exact test), Q value = 0.48

Table S500. Gene #167: 'ZMYM3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZMYM3 MUTATED | 5 | 1 | 1 | 3
ZMYM3 WILD-TYPE | 30 | 32 | 15 | 9

'ZMYM3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0349 (Fisher's exact test), Q value = 0.42

Table S501. Gene #167: 'ZMYM3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZMYM3 MUTATED | 4 | 0 | 1 | 1 | 3 | 0 | 1
ZMYM3 WILD-TYPE | 30 | 11 | 8 | 6 | 3 | 20 | 8

Figure S68. Get High-res Image Gene #167: 'ZMYM3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'C1ORF114 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.64 (Fisher's exact test), Q value = 0.84

Table S502. Gene #168: 'C1ORF114 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C1ORF114 MUTATED | 1 | 3 | 1 | 1 | 1
C1ORF114 WILD-TYPE | 27 | 17 | 10 | 19 | 20

'C1ORF114 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.352 (Fisher's exact test), Q value = 0.68

Table S503. Gene #168: 'C1ORF114 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C1ORF114 MUTATED | 4 | 1 | 2 | 0
C1ORF114 WILD-TYPE | 31 | 32 | 14 | 12

'C1ORF114 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.193 (Fisher's exact test), Q value = 0.56

Table S504. Gene #168: 'C1ORF114 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C1ORF114 MUTATED | 3 | 0 | 1 | 2 | 0 | 0 | 1
C1ORF114 WILD-TYPE | 31 | 11 | 8 | 5 | 6 | 20 | 8

'TEX10 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.982 (Fisher's exact test), Q value = 1

Table S505. Gene #169: 'TEX10 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TEX10 MUTATED | 3 | 2 | 1 | 1 | 2
TEX10 WILD-TYPE | 25 | 18 | 10 | 19 | 19

'TEX10 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0182 (Fisher's exact test), Q value = 0.4

Table S506. Gene #169: 'TEX10 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TEX10 MUTATED | 6 | 0 | 3 | 0
TEX10 WILD-TYPE | 29 | 33 | 13 | 12

Figure S69. Get High-res Image Gene #169: 'TEX10 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'TEX10 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.019 (Fisher's exact test), Q value = 0.4

Table S507. Gene #169: 'TEX10 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TEX10 MUTATED | 6 | 0 | 0 | 3 | 0 | 0 | 0
TEX10 WILD-TYPE | 28 | 11 | 9 | 4 | 6 | 20 | 9

Figure S70. Get High-res Image Gene #169: 'TEX10 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'WAC MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.351 (Fisher's exact test), Q value = 0.68

Table S508. Gene #170: 'WAC MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
WAC MUTATED | 1 | 1 | 1 | 0 | 3
WAC WILD-TYPE | 27 | 19 | 10 | 20 | 18

'WAC MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.111 (Fisher's exact test), Q value = 0.48

Table S509. Gene #170: 'WAC MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
WAC MUTATED | 3 | 0 | 1 | 2
WAC WILD-TYPE | 32 | 33 | 15 | 10

'WAC MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0966 (Fisher's exact test), Q value = 0.48

Table S510. Gene #170: 'WAC MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
WAC MUTATED | 3 | 0 | 0 | 1 | 2 | 0 | 0
WAC WILD-TYPE | 31 | 11 | 9 | 6 | 4 | 20 | 9

'CADPS MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.567 (Fisher's exact test), Q value = 0.78

Table S511. Gene #171: 'CADPS MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CADPS MUTATED | 1 | 3 | 1 | 3 | 2
CADPS WILD-TYPE | 27 | 17 | 10 | 17 | 19

'CADPS MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.309 (Fisher's exact test), Q value = 0.65

Table S512. Gene #171: 'CADPS MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CADPS MUTATED | 5 | 2 | 3 | 0
CADPS WILD-TYPE | 30 | 31 | 13 | 12

'CADPS MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.288 (Fisher's exact test), Q value = 0.64

Table S513. Gene #171: 'CADPS MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CADPS MUTATED | 6 | 0 | 0 | 2 | 0 | 1 | 1
CADPS WILD-TYPE | 28 | 11 | 9 | 5 | 6 | 19 | 8

'FAM60A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.304 (Fisher's exact test), Q value = 0.65

Table S514. Gene #172: 'FAM60A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FAM60A MUTATED | 1 | 2 | 0 | 0 | 3
FAM60A WILD-TYPE | 27 | 18 | 11 | 20 | 18

'FAM60A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.934 (Fisher's exact test), Q value = 0.99

Table S515. Gene #172: 'FAM60A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FAM60A MUTATED | 3 | 2 | 1 | 0
FAM60A WILD-TYPE | 32 | 31 | 15 | 12

'FAM60A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.856 (Fisher's exact test), Q value = 0.94

Table S516. Gene #172: 'FAM60A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FAM60A MUTATED | 4 | 0 | 0 | 0 | 0 | 1 | 1
FAM60A WILD-TYPE | 30 | 11 | 9 | 7 | 6 | 19 | 8

'PSG1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.958 (Fisher's exact test), Q value = 1

Table S517. Gene #173: 'PSG1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PSG1 MUTATED | 1 | 1 | 1 | 1 | 1
PSG1 WILD-TYPE | 27 | 19 | 10 | 19 | 20

'PSG1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.793 (Fisher's exact test), Q value = 0.92

Table S518. Gene #173: 'PSG1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PSG1 MUTATED | 1 | 2 | 1 | 1
PSG1 WILD-TYPE | 34 | 31 | 15 | 11

'PSG1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.145 (Fisher's exact test), Q value = 0.53

Table S519. Gene #173: 'PSG1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PSG1 MUTATED | 1 | 2 | 0 | 0 | 1 | 0 | 1
PSG1 WILD-TYPE | 33 | 9 | 9 | 7 | 5 | 20 | 8

'MLH3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.101 (Fisher's exact test), Q value = 0.48

Table S520. Gene #174: 'MLH3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MLH3 MUTATED | 1 | 1 | 0 | 0 | 4
MLH3 WILD-TYPE | 27 | 19 | 11 | 20 | 17

'MLH3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0359 (Fisher's exact test), Q value = 0.42

Table S521. Gene #174: 'MLH3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MLH3 MUTATED | 4 | 0 | 0 | 2
MLH3 WILD-TYPE | 31 | 33 | 16 | 10

Figure S71. Get High-res Image Gene #174: 'MLH3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'MLH3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.11 (Fisher's exact test), Q value = 0.48

Table S522. Gene #174: 'MLH3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MLH3 MUTATED | 4 | 0 | 0 | 0 | 2 | 0 | 0
MLH3 WILD-TYPE | 30 | 11 | 9 | 7 | 4 | 20 | 9

'NFASC MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.302 (Fisher's exact test), Q value = 0.65

Table S523. Gene #175: 'NFASC MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NFASC MUTATED | 2 | 1 | 1 | 1 | 5
NFASC WILD-TYPE | 26 | 19 | 10 | 19 | 16

'NFASC MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0416 (Fisher's exact test), Q value = 0.42

Table S524. Gene #175: 'NFASC MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NFASC MUTATED | 6 | 0 | 2 | 2
NFASC WILD-TYPE | 29 | 33 | 14 | 10

Figure S72. Get High-res Image Gene #175: 'NFASC MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'NFASC MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0387 (Fisher's exact test), Q value = 0.42

Table S525. Gene #175: 'NFASC MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NFASC MUTATED | 7 | 0 | 0 | 1 | 2 | 0 | 0
NFASC WILD-TYPE | 27 | 11 | 9 | 6 | 4 | 20 | 9

Figure S73. Get High-res Image Gene #175: 'NFASC MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'ENTPD2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.552 (Fisher's exact test), Q value = 0.77

Table S526. Gene #176: 'ENTPD2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ENTPD2 MUTATED | 0 | 1 | 1 | 1 | 1
ENTPD2 WILD-TYPE | 28 | 19 | 10 | 19 | 20

'ENTPD2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.652 (Fisher's exact test), Q value = 0.84

Table S527. Gene #176: 'ENTPD2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ENTPD2 MUTATED | 1 | 1 | 1 | 1
ENTPD2 WILD-TYPE | 34 | 32 | 15 | 11

'ENTPD2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0876 (Fisher's exact test), Q value = 0.47

Table S528. Gene #176: 'ENTPD2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ENTPD2 MUTATED | 0 | 0 | 0 | 1 | 1 | 1 | 1
ENTPD2 WILD-TYPE | 34 | 11 | 9 | 6 | 5 | 19 | 8

'SFRS2B MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.549 (Fisher's exact test), Q value = 0.77

Table S529. Gene #177: 'SFRS2B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SFRS2B MUTATED | 1 | 0 | 1 | 1 | 0
SFRS2B WILD-TYPE | 27 | 20 | 10 | 19 | 21

'SFRS2B MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.603 (Fisher's exact test), Q value = 0.81

Table S530. Gene #177: 'SFRS2B MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SFRS2B MUTATED | 1 | 1 | 0 | 1
SFRS2B WILD-TYPE | 34 | 32 | 16 | 11

'SFRS2B MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.55 (Fisher's exact test), Q value = 0.77

Table S531. Gene #177: 'SFRS2B MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SFRS2B MUTATED | 1 | 0 | 0 | 0 | 1 | 1 | 0
SFRS2B WILD-TYPE | 33 | 11 | 9 | 7 | 5 | 19 | 9

'XKR6 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.182 (Fisher's exact test), Q value = 0.56

Table S532. Gene #178: 'XKR6 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
XKR6 MUTATED | 0 | 2 | 1 | 0 | 2
XKR6 WILD-TYPE | 28 | 18 | 10 | 20 | 19

'XKR6 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.104 (Fisher's exact test), Q value = 0.48

Table S533. Gene #178: 'XKR6 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
XKR6 MUTATED | 4 | 0 | 0 | 1
XKR6 WILD-TYPE | 31 | 33 | 16 | 11

'XKR6 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.377 (Fisher's exact test), Q value = 0.68

Table S534. Gene #178: 'XKR6 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
XKR6 MUTATED | 3 | 0 | 0 | 0 | 1 | 0 | 1
XKR6 WILD-TYPE | 31 | 11 | 9 | 7 | 5 | 20 | 8

'KIAA1267 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.19 (Fisher's exact test), Q value = 0.56

Table S535. Gene #179: 'KIAA1267 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KIAA1267 MUTATED | 3 | 0 | 2 | 1 | 4
KIAA1267 WILD-TYPE | 25 | 20 | 9 | 19 | 17

'KIAA1267 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0278 (Fisher's exact test), Q value = 0.42

Table S536. Gene #179: 'KIAA1267 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KIAA1267 MUTATED | 8 | 1 | 0 | 1
KIAA1267 WILD-TYPE | 27 | 32 | 16 | 11

Figure S74. Get High-res Image Gene #179: 'KIAA1267 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'KIAA1267 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.145 (Fisher's exact test), Q value = 0.53

Table S537. Gene #179: 'KIAA1267 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KIAA1267 MUTATED | 8 | 0 | 0 | 0 | 1 | 1 | 0
KIAA1267 WILD-TYPE | 26 | 11 | 9 | 7 | 5 | 19 | 9

'SGOL2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.217 (Fisher's exact test), Q value = 0.58

Table S538. Gene #180: 'SGOL2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SGOL2 MUTATED | 0 | 2 | 0 | 2 | 3
SGOL2 WILD-TYPE | 28 | 18 | 11 | 18 | 18

'SGOL2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.037 (Fisher's exact test), Q value = 0.42

Table S539. Gene #180: 'SGOL2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SGOL2 MUTATED | 6 | 0 | 1 | 0
SGOL2 WILD-TYPE | 29 | 33 | 15 | 12

Figure S75. Get High-res Image Gene #180: 'SGOL2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'SGOL2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.217 (Fisher's exact test), Q value = 0.58

Table S540. Gene #180: 'SGOL2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SGOL2 MUTATED | 6 | 0 | 1 | 0 | 0 | 0 | 0
SGOL2 WILD-TYPE | 28 | 11 | 8 | 7 | 6 | 20 | 9

'MSH6 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.719 (Fisher's exact test), Q value = 0.88

Table S541. Gene #181: 'MSH6 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MSH6 MUTATED | 2 | 2 | 0 | 3 | 1
MSH6 WILD-TYPE | 26 | 18 | 11 | 17 | 20

'MSH6 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.412 (Fisher's exact test), Q value = 0.69

Table S542. Gene #181: 'MSH6 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MSH6 MUTATED | 5 | 1 | 1 | 1
MSH6 WILD-TYPE | 30 | 32 | 15 | 11

'MSH6 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.185 (Fisher's exact test), Q value = 0.56

Table S543. Gene #181: 'MSH6 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MSH6 MUTATED | 6 | 0 | 0 | 0 | 1 | 0 | 1
MSH6 WILD-TYPE | 28 | 11 | 9 | 7 | 5 | 20 | 8

'TP53BP1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.179 (Fisher's exact test), Q value = 0.56

Table S544. Gene #182: 'TP53BP1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TP53BP1 MUTATED | 2 | 4 | 2 | 0 | 2
TP53BP1 WILD-TYPE | 26 | 16 | 9 | 20 | 19

'TP53BP1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00539 (Fisher's exact test), Q value = 0.32

Table S545. Gene #182: 'TP53BP1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TP53BP1 MUTATED | 9 | 1 | 0 | 0
TP53BP1 WILD-TYPE | 26 | 32 | 16 | 12

Figure S76. Get High-res Image Gene #182: 'TP53BP1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'TP53BP1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0717 (Fisher's exact test), Q value = 0.47

Table S546. Gene #182: 'TP53BP1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TP53BP1 MUTATED | 9 | 0 | 0 | 0 | 0 | 1 | 0
TP53BP1 WILD-TYPE | 25 | 11 | 9 | 7 | 6 | 19 | 9

'IFIH1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.667 (Fisher's exact test), Q value = 0.85

Table S547. Gene #183: 'IFIH1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
IFIH1 MUTATED | 3 | 1 | 1 | 0 | 2
IFIH1 WILD-TYPE | 25 | 19 | 10 | 20 | 19

'IFIH1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.102 (Fisher's exact test), Q value = 0.48

Table S548. Gene #183: 'IFIH1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
IFIH1 MUTATED | 4 | 0 | 2 | 0
IFIH1 WILD-TYPE | 31 | 33 | 14 | 12

'IFIH1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.146 (Fisher's exact test), Q value = 0.53

Table S549. Gene #183: 'IFIH1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
IFIH1 MUTATED | 4 | 0 | 0 | 2 | 0 | 0 | 0
IFIH1 WILD-TYPE | 30 | 11 | 9 | 5 | 6 | 20 | 9

'MRI1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.37 (Fisher's exact test), Q value = 0.68

Table S550. Gene #184: 'MRI1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MRI1 MUTATED | 0 | 1 | 1 | 0 | 1
MRI1 WILD-TYPE | 28 | 19 | 10 | 20 | 20

'MRI1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.333 (Fisher's exact test), Q value = 0.67

Table S551. Gene #184: 'MRI1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MRI1 MUTATED | 1 | 0 | 1 | 1
MRI1 WILD-TYPE | 34 | 33 | 15 | 11

'MRI1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.49 (Fisher's exact test), Q value = 0.75

Table S552. Gene #184: 'MRI1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MRI1 MUTATED | 2 | 0 | 0 | 0 | 1 | 0 | 0
MRI1 WILD-TYPE | 32 | 11 | 9 | 7 | 5 | 20 | 9

'PAPPA2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.657 (Fisher's exact test), Q value = 0.84

Table S553. Gene #185: 'PAPPA2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PAPPA2 MUTATED | 4 | 2 | 0 | 2 | 4
PAPPA2 WILD-TYPE | 24 | 18 | 11 | 18 | 17

'PAPPA2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0147 (Fisher's exact test), Q value = 0.39

Table S554. Gene #185: 'PAPPA2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PAPPA2 MUTATED | 6 | 0 | 3 | 3
PAPPA2 WILD-TYPE | 29 | 33 | 13 | 9

Figure S77. Get High-res Image Gene #185: 'PAPPA2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'PAPPA2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0142 (Fisher's exact test), Q value = 0.39

Table S555. Gene #185: 'PAPPA2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PAPPA2 MUTATED | 8 | 0 | 0 | 2 | 2 | 0 | 0
PAPPA2 WILD-TYPE | 26 | 11 | 9 | 5 | 4 | 20 | 9

Figure S78. Get High-res Image Gene #185: 'PAPPA2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'KRTAP10-1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S556. Gene #186: 'KRTAP10-1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KRTAP10-1 MUTATED | 1 | 0 | 0 | 1 | 1
KRTAP10-1 WILD-TYPE | 27 | 20 | 11 | 19 | 20

'KRTAP10-1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.382 (Fisher's exact test), Q value = 0.68

Table S557. Gene #186: 'KRTAP10-1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KRTAP10-1 MUTATED | 2 | 0 | 0 | 1
KRTAP10-1 WILD-TYPE | 33 | 33 | 16 | 11

'KRTAP10-1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.491 (Fisher's exact test), Q value = 0.75

Table S558. Gene #186: 'KRTAP10-1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KRTAP10-1 MUTATED | 2 | 0 | 0 | 0 | 1 | 0 | 0
KRTAP10-1 WILD-TYPE | 32 | 11 | 9 | 7 | 5 | 20 | 9

'PIK3R2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.104 (Fisher's exact test), Q value = 0.48

Table S559. Gene #187: 'PIK3R2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PIK3R2 MUTATED | 1 | 1 | 0 | 1 | 5
PIK3R2 WILD-TYPE | 27 | 19 | 11 | 19 | 16

'PIK3R2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.945 (Fisher's exact test), Q value = 0.99

Table S560. Gene #187: 'PIK3R2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PIK3R2 MUTATED | 2 | 3 | 1 | 1
PIK3R2 WILD-TYPE | 33 | 30 | 15 | 11

'PIK3R2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.849 (Fisher's exact test), Q value = 0.94

Table S561. Gene #187: 'PIK3R2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PIK3R2 MUTATED | 3 | 1 | 0 | 0 | 1 | 1 | 1
PIK3R2 WILD-TYPE | 31 | 10 | 9 | 7 | 5 | 19 | 8

'SDAD1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.00755 (Fisher's exact test), Q value = 0.38

Table S562. Gene #188: 'SDAD1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SDAD1 MUTATED | 0 | 0 | 0 | 0 | 4
SDAD1 WILD-TYPE | 28 | 20 | 11 | 20 | 17

Figure S79. Get High-res Image Gene #188: 'SDAD1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

'SDAD1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.353 (Fisher's exact test), Q value = 0.68

Table S563. Gene #188: 'SDAD1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SDAD1 MUTATED | 2 | 0 | 1 | 1
SDAD1 WILD-TYPE | 33 | 33 | 15 | 11

'SDAD1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.403 (Fisher's exact test), Q value = 0.69

Table S564. Gene #188: 'SDAD1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SDAD1 MUTATED | 3 | 0 | 0 | 0 | 1 | 0 | 0
SDAD1 WILD-TYPE | 31 | 11 | 9 | 7 | 5 | 20 | 9

'GOLGA5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.37 (Fisher's exact test), Q value = 0.68

Table S565. Gene #189: 'GOLGA5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
GOLGA5 MUTATED | 0 | 1 | 1 | 0 | 1
GOLGA5 WILD-TYPE | 28 | 19 | 10 | 20 | 20

'GOLGA5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.505 (Fisher's exact test), Q value = 0.75

Table S566. Gene #189: 'GOLGA5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
GOLGA5 MUTATED | 2 | 0 | 1 | 0
GOLGA5 WILD-TYPE | 33 | 33 | 15 | 12

'GOLGA5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.518 (Fisher's exact test), Q value = 0.76

Table S567. Gene #189: 'GOLGA5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
GOLGA5 MUTATED | 2 | 0 | 0 | 1 | 0 | 0 | 0
GOLGA5 WILD-TYPE | 32 | 11 | 9 | 6 | 6 | 20 | 9

'MAGI1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0843 (Fisher's exact test), Q value = 0.47

Table S568. Gene #190: 'MAGI1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MAGI1 MUTATED | 0 | 0 | 1 | 3 | 1
MAGI1 WILD-TYPE | 28 | 20 | 10 | 17 | 20

'MAGI1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.737 (Fisher's exact test), Q value = 0.89

Table S569. Gene #190: 'MAGI1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MAGI1 MUTATED | 3 | 1 | 1 | 0
MAGI1 WILD-TYPE | 32 | 32 | 15 | 12

'MAGI1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.793 (Fisher's exact test), Q value = 0.92

Table S570. Gene #190: 'MAGI1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MAGI1 MUTATED | 3 | 0 | 0 | 1 | 0 | 1 | 0
MAGI1 WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 19 | 9

'PRUNE2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.405 (Fisher's exact test), Q value = 0.69

Table S571. Gene #191: 'PRUNE2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PRUNE2 MUTATED | 2 | 4 | 1 | 4 | 1
PRUNE2 WILD-TYPE | 26 | 16 | 10 | 16 | 20

'PRUNE2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.677 (Fisher's exact test), Q value = 0.85

Table S572. Gene #191: 'PRUNE2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PRUNE2 MUTATED | 5 | 4 | 2 | 0
PRUNE2 WILD-TYPE | 30 | 29 | 14 | 12

'PRUNE2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.386 (Fisher's exact test), Q value = 0.68

Table S573. Gene #191: 'PRUNE2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PRUNE2 MUTATED | 4 | 0 | 1 | 2 | 0 | 4 | 0
PRUNE2 WILD-TYPE | 30 | 11 | 8 | 5 | 6 | 16 | 9

'MXRA8 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S574. Gene #192: 'MXRA8 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MXRA8 MUTATED | 2 | 1 | 0 | 1 | 1
MXRA8 WILD-TYPE | 26 | 19 | 11 | 19 | 20

'MXRA8 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S575. Gene #192: 'MXRA8 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MXRA8 MUTATED | 2 | 2 | 1 | 0
MXRA8 WILD-TYPE | 33 | 31 | 15 | 12

'MXRA8 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.904 (Fisher's exact test), Q value = 0.97

Table S576. Gene #192: 'MXRA8 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MXRA8 MUTATED | 3 | 0 | 0 | 0 | 0 | 1 | 1
MXRA8 WILD-TYPE | 31 | 11 | 9 | 7 | 6 | 19 | 8

'WDR47 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.567 (Fisher's exact test), Q value = 0.78

Table S577. Gene #193: 'WDR47 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
WDR47 MUTATED | 1 | 3 | 0 | 1 | 2
WDR47 WILD-TYPE | 27 | 17 | 11 | 19 | 19

'WDR47 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0937 (Fisher's exact test), Q value = 0.47

Table S578. Gene #193: 'WDR47 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
WDR47 MUTATED | 6 | 1 | 0 | 0
WDR47 WILD-TYPE | 29 | 32 | 16 | 12

'WDR47 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.217 (Fisher's exact test), Q value = 0.58

Table S579. Gene #193: 'WDR47 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
WDR47 MUTATED | 6 | 0 | 0 | 0 | 0 | 0 | 1
WDR47 WILD-TYPE | 28 | 11 | 9 | 7 | 6 | 20 | 8

'ANK3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.314 (Fisher's exact test), Q value = 0.65

Table S580. Gene #194: 'ANK3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ANK3 MUTATED | 1 | 4 | 2 | 2 | 4
ANK3 WILD-TYPE | 27 | 16 | 9 | 18 | 17

'ANK3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00573 (Fisher's exact test), Q value = 0.32

Table S581. Gene #194: 'ANK3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ANK3 MUTATED | 9 | 0 | 3 | 1
ANK3 WILD-TYPE | 26 | 33 | 13 | 11

Figure S80. Get High-res Image Gene #194: 'ANK3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'ANK3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0246 (Fisher's exact test), Q value = 0.41

Table S582. Gene #194: 'ANK3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ANK3 MUTATED | 10 | 0 | 0 | 1 | 1 | 0 | 1
ANK3 WILD-TYPE | 24 | 11 | 9 | 6 | 5 | 20 | 8

Figure S81. Get High-res Image Gene #194: 'ANK3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'MED25 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.591 (Fisher's exact test), Q value = 0.8

Table S583. Gene #195: 'MED25 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MED25 MUTATED | 1 | 0 | 1 | 1 | 2
MED25 WILD-TYPE | 27 | 20 | 10 | 19 | 19

'MED25 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.265 (Fisher's exact test), Q value = 0.63

Table S584. Gene #195: 'MED25 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MED25 MUTATED | 3 | 0 | 1 | 1
MED25 WILD-TYPE | 32 | 33 | 15 | 11

'MED25 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.382 (Fisher's exact test), Q value = 0.68

Table S585. Gene #195: 'MED25 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MED25 MUTATED | 4 | 0 | 0 | 1 | 0 | 0 | 0
MED25 WILD-TYPE | 30 | 11 | 9 | 6 | 6 | 20 | 9

'LRCH2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.312 (Fisher's exact test), Q value = 0.65

Table S586. Gene #196: 'LRCH2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LRCH2 MUTATED | 1 | 4 | 1 | 1 | 1
LRCH2 WILD-TYPE | 27 | 16 | 10 | 19 | 20

'LRCH2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.55 (Fisher's exact test), Q value = 0.77

Table S587. Gene #196: 'LRCH2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LRCH2 MUTATED | 5 | 2 | 1 | 0
LRCH2 WILD-TYPE | 30 | 31 | 15 | 12

'LRCH2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.868 (Fisher's exact test), Q value = 0.95

Table S588. Gene #196: 'LRCH2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LRCH2 MUTATED | 4 | 0 | 1 | 1 | 0 | 2 | 0
LRCH2 WILD-TYPE | 30 | 11 | 8 | 6 | 6 | 18 | 9

'SALL4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.755 (Fisher's exact test), Q value = 0.9

Table S589. Gene #197: 'SALL4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SALL4 MUTATED | 2 | 1 | 0 | 1 | 3
SALL4 WILD-TYPE | 26 | 19 | 11 | 19 | 18

'SALL4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.166 (Fisher's exact test), Q value = 0.56

Table S590. Gene #197: 'SALL4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SALL4 MUTATED | 4 | 1 | 0 | 2
SALL4 WILD-TYPE | 31 | 32 | 16 | 10

'SALL4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.12 (Fisher's exact test), Q value = 0.49

Table S591. Gene #197: 'SALL4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SALL4 MUTATED | 4 | 0 | 0 | 0 | 2 | 0 | 1
SALL4 WILD-TYPE | 30 | 11 | 9 | 7 | 4 | 20 | 8

'RTKN2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0781 (Fisher's exact test), Q value = 0.47

Table S592. Gene #198: 'RTKN2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RTKN2 MUTATED | 0 | 0 | 0 | 2 | 3
RTKN2 WILD-TYPE | 28 | 20 | 11 | 18 | 18

'RTKN2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.189 (Fisher's exact test), Q value = 0.56

Table S593. Gene #198: 'RTKN2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RTKN2 MUTATED | 2 | 0 | 2 | 1
RTKN2 WILD-TYPE | 33 | 33 | 14 | 11

'RTKN2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.309 (Fisher's exact test), Q value = 0.65

Table S594. Gene #198: 'RTKN2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RTKN2 MUTATED | 2 | 1 | 0 | 1 | 1 | 0 | 0
RTKN2 WILD-TYPE | 32 | 10 | 9 | 6 | 5 | 20 | 9

'TTC39B MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.287 (Fisher's exact test), Q value = 0.64

Table S595. Gene #199: 'TTC39B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TTC39B MUTATED | 0 | 1 | 0 | 0 | 2
TTC39B WILD-TYPE | 28 | 19 | 11 | 20 | 19

'TTC39B MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.38 (Fisher's exact test), Q value = 0.68

Table S596. Gene #199: 'TTC39B MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TTC39B MUTATED | 2 | 0 | 0 | 1
TTC39B WILD-TYPE | 33 | 33 | 16 | 11

'TTC39B MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.497 (Fisher's exact test), Q value = 0.75

Table S597. Gene #199: 'TTC39B MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TTC39B MUTATED | 2 | 0 | 0 | 0 | 1 | 0 | 0
TTC39B WILD-TYPE | 32 | 11 | 9 | 7 | 5 | 20 | 9

'CDH24 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.86 (Fisher's exact test), Q value = 0.94

Table S598. Gene #200: 'CDH24 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CDH24 MUTATED | 2 | 1 | 0 | 1 | 0
CDH24 WILD-TYPE | 26 | 19 | 11 | 19 | 21

'CDH24 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.32 (Fisher's exact test), Q value = 0.65

Table S599. Gene #200: 'CDH24 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CDH24 MUTATED | 3 | 0 | 1 | 0
CDH24 WILD-TYPE | 32 | 33 | 15 | 12

'CDH24 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.573 (Fisher's exact test), Q value = 0.78

Table S600. Gene #200: 'CDH24 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CDH24 MUTATED | 4 | 0 | 0 | 0 | 0 | 0 | 0
CDH24 WILD-TYPE | 30 | 11 | 9 | 7 | 6 | 20 | 9

'PRR12 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.551 (Fisher's exact test), Q value = 0.77

Table S601. Gene #201: 'PRR12 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PRR12 MUTATED | 1 | 1 | 2 | 2 | 2
PRR12 WILD-TYPE | 27 | 19 | 9 | 18 | 19

'PRR12 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.151 (Fisher's exact test), Q value = 0.54

Table S602. Gene #201: 'PRR12 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PRR12 MUTATED | 3 | 1 | 1 | 3
PRR12 WILD-TYPE | 32 | 32 | 15 | 9

'PRR12 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.115 (Fisher's exact test), Q value = 0.48

Table S603. Gene #201: 'PRR12 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PRR12 MUTATED | 4 | 0 | 0 | 1 | 2 | 0 | 1
PRR12 WILD-TYPE | 30 | 11 | 9 | 6 | 4 | 20 | 8

'MSL3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.719 (Fisher's exact test), Q value = 0.88

Table S604. Gene #202: 'MSL3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MSL3 MUTATED | 3 | 3 | 0 | 1 | 2
MSL3 WILD-TYPE | 25 | 17 | 11 | 19 | 19

'MSL3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.178 (Fisher's exact test), Q value = 0.56

Table S605. Gene #202: 'MSL3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MSL3 MUTATED | 4 | 1 | 3 | 0
MSL3 WILD-TYPE | 31 | 32 | 13 | 12

'MSL3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.279 (Fisher's exact test), Q value = 0.63

Table S606. Gene #202: 'MSL3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MSL3 MUTATED | 3 | 1 | 1 | 2 | 0 | 0 | 1
MSL3 WILD-TYPE | 31 | 10 | 8 | 5 | 6 | 20 | 8

'PAX6 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.206 (Fisher's exact test), Q value = 0.58

Table S607. Gene #203: 'PAX6 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PAX6 MUTATED | 0 | 3 | 1 | 1 | 1
PAX6 WILD-TYPE | 28 | 17 | 10 | 19 | 20

'PAX6 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.82 (Fisher's exact test), Q value = 0.93

Table S608. Gene #203: 'PAX6 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PAX6 MUTATED | 3 | 1 | 1 | 1
PAX6 WILD-TYPE | 32 | 32 | 15 | 11

'PAX6 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.262 (Fisher's exact test), Q value = 0.63

Table S609. Gene #203: 'PAX6 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PAX6 MUTATED | 2 | 0 | 1 | 1 | 1 | 0 | 1
PAX6 WILD-TYPE | 32 | 11 | 8 | 6 | 5 | 20 | 8

'FLJ10357 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.763 (Fisher's exact test), Q value = 0.9

Table S610. Gene #204: 'FLJ10357 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FLJ10357 MUTATED | 2 | 3 | 0 | 2 | 3
FLJ10357 WILD-TYPE | 26 | 17 | 11 | 18 | 18

'FLJ10357 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0135 (Fisher's exact test), Q value = 0.39

Table S611. Gene #204: 'FLJ10357 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FLJ10357 MUTATED | 3 | 0 | 3 | 3
FLJ10357 WILD-TYPE | 32 | 33 | 13 | 9

Figure S82. Get High-res Image Gene #204: 'FLJ10357 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'FLJ10357 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0382 (Fisher's exact test), Q value = 0.42

Table S612. Gene #204: 'FLJ10357 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FLJ10357 MUTATED | 5 | 0 | 0 | 2 | 2 | 0 | 0
FLJ10357 WILD-TYPE | 29 | 11 | 9 | 5 | 4 | 20 | 9

Figure S83. Get High-res Image Gene #204: 'FLJ10357 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'USMG5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.684 (Fisher's exact test), Q value = 0.86

Table S613. Gene #205: 'USMG5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
USMG5 MUTATED | 2 | 1 | 0 | 0 | 0
USMG5 WILD-TYPE | 26 | 19 | 11 | 20 | 21

'USMG5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00543 (Fisher's exact test), Q value = 0.32

Table S614. Gene #205: 'USMG5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
USMG5 MUTATED | 0 | 0 | 3 | 0
USMG5 WILD-TYPE | 35 | 33 | 13 | 12

Figure S84. Get High-res Image Gene #205: 'USMG5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'USMG5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.52 (Fisher's exact test), Q value = 0.76

Table S615. Gene #205: 'USMG5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
USMG5 MUTATED | 2 | 0 | 0 | 1 | 0 | 0 | 0
USMG5 WILD-TYPE | 32 | 11 | 9 | 6 | 6 | 20 | 9

'TFDP1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.27 (Fisher's exact test), Q value = 0.63

Table S616. Gene #206: 'TFDP1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TFDP1 MUTATED | 1 | 3 | 0 | 0 | 2
TFDP1 WILD-TYPE | 27 | 17 | 11 | 20 | 19

'TFDP1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.535 (Fisher's exact test), Q value = 0.77

Table S617. Gene #206: 'TFDP1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TFDP1 MUTATED | 4 | 1 | 1 | 0
TFDP1 WILD-TYPE | 31 | 32 | 15 | 12

'TFDP1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.473 (Fisher's exact test), Q value = 0.75

Table S618. Gene #206: 'TFDP1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TFDP1 MUTATED | 4 | 1 | 0 | 1 | 0 | 0 | 0
TFDP1 WILD-TYPE | 30 | 10 | 9 | 6 | 6 | 20 | 9

'WIF1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.338 (Fisher's exact test), Q value = 0.67

Table S619. Gene #207: 'WIF1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
WIF1 MUTATED | 1 | 1 | 0 | 0 | 3
WIF1 WILD-TYPE | 27 | 19 | 11 | 20 | 18

'WIF1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.918 (Fisher's exact test), Q value = 0.98

Table S620. Gene #207: 'WIF1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
WIF1 MUTATED | 2 | 1 | 1 | 1
WIF1 WILD-TYPE | 33 | 32 | 15 | 11

'WIF1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.405 (Fisher's exact test), Q value = 0.69

Table S621. Gene #207: 'WIF1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
WIF1 MUTATED | 2 | 1 | 0 | 0 | 1 | 0 | 1
WIF1 WILD-TYPE | 32 | 10 | 9 | 7 | 5 | 20 | 8

'ATXN2L MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.557 (Fisher's exact test), Q value = 0.78

Table S622. Gene #208: 'ATXN2L MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ATXN2L MUTATED | 3 | 0 | 1 | 2 | 3
ATXN2L WILD-TYPE | 25 | 20 | 10 | 18 | 18

'ATXN2L MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0497 (Fisher's exact test), Q value = 0.43

Table S623. Gene #208: 'ATXN2L MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ATXN2L MUTATED | 6 | 0 | 2 | 1
ATXN2L WILD-TYPE | 29 | 33 | 14 | 11

Figure S85. Get High-res Image Gene #208: 'ATXN2L MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'ATXN2L MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0695 (Fisher's exact test), Q value = 0.46

Table S624. Gene #208: 'ATXN2L MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ATXN2L MUTATED | 6 | 0 | 0 | 2 | 1 | 0 | 0
ATXN2L WILD-TYPE | 28 | 11 | 9 | 5 | 5 | 20 | 9

'FLT3LG MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.723 (Fisher's exact test), Q value = 0.88

Table S625. Gene #209: 'FLT3LG MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FLT3LG MUTATED | 1 | 1 | 0 | 0 | 2
FLT3LG WILD-TYPE | 27 | 19 | 11 | 20 | 19

'FLT3LG MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.649 (Fisher's exact test), Q value = 0.84

Table S626. Gene #209: 'FLT3LG MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FLT3LG MUTATED | 1 | 1 | 1 | 1
FLT3LG WILD-TYPE | 34 | 32 | 15 | 11

'FLT3LG MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.791 (Fisher's exact test), Q value = 0.92

Table S627. Gene #209: 'FLT3LG MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FLT3LG MUTATED | 2 | 0 | 0 | 0 | 1 | 1 | 0
FLT3LG WILD-TYPE | 32 | 11 | 9 | 7 | 5 | 19 | 9

'POLG MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.461 (Fisher's exact test), Q value = 0.74

Table S628. Gene #210: 'POLG MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
POLG MUTATED | 3 | 3 | 1 | 0 | 3
POLG WILD-TYPE | 25 | 17 | 10 | 20 | 18

'POLG MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0174 (Fisher's exact test), Q value = 0.4

Table S629. Gene #210: 'POLG MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
POLG MUTATED | 4 | 0 | 4 | 2
POLG WILD-TYPE | 31 | 33 | 12 | 10

Figure S86. Get High-res Image Gene #210: 'POLG MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'POLG MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.068 (Fisher's exact test), Q value = 0.45

Table S630. Gene #210: 'POLG MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
POLG MUTATED | 7 | 0 | 1 | 2 | 0 | 0 | 0
POLG WILD-TYPE | 27 | 11 | 8 | 5 | 6 | 20 | 9

'EIF2AK3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.983 (Fisher's exact test), Q value = 1

Table S631. Gene #211: 'EIF2AK3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
EIF2AK3 MUTATED | 3 | 2 | 1 | 1 | 2
EIF2AK3 WILD-TYPE | 25 | 18 | 10 | 19 | 19

'EIF2AK3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0666 (Fisher's exact test), Q value = 0.45

Table S632. Gene #211: 'EIF2AK3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
EIF2AK3 MUTATED | 5 | 0 | 2 | 2
EIF2AK3 WILD-TYPE | 30 | 33 | 14 | 10

'EIF2AK3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0915 (Fisher's exact test), Q value = 0.47

Table S633. Gene #211: 'EIF2AK3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
EIF2AK3 MUTATED | 7 | 0 | 0 | 1 | 1 | 0 | 0
EIF2AK3 WILD-TYPE | 27 | 11 | 9 | 6 | 5 | 20 | 9

'GLTSCR1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.39 (Fisher's exact test), Q value = 0.68

Table S634. Gene #212: 'GLTSCR1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
GLTSCR1 MUTATED | 6 | 1 | 1 | 3 | 1
GLTSCR1 WILD-TYPE | 22 | 19 | 10 | 17 | 20

'GLTSCR1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0376 (Fisher's exact test), Q value = 0.42

Table S635. Gene #212: 'GLTSCR1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
GLTSCR1 MUTATED | 4 | 1 | 5 | 1
GLTSCR1 WILD-TYPE | 31 | 32 | 11 | 11

Figure S87. Get High-res Image Gene #212: 'GLTSCR1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'GLTSCR1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.553 (Fisher's exact test), Q value = 0.77

Table S636. Gene #212: 'GLTSCR1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
GLTSCR1 MUTATED | 5 | 1 | 1 | 2 | 1 | 1 | 0
GLTSCR1 WILD-TYPE | 29 | 10 | 8 | 5 | 5 | 19 | 9

'CYTSB MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.725 (Fisher's exact test), Q value = 0.88

Table S637. Gene #213: 'CYTSB MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CYTSB MUTATED | 2 | 2 | 2 | 2 | 1
CYTSB WILD-TYPE | 26 | 18 | 9 | 18 | 20

'CYTSB MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0134 (Fisher's exact test), Q value = 0.39

Table S638. Gene #213: 'CYTSB MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CYTSB MUTATED | 7 | 0 | 2 | 0
CYTSB WILD-TYPE | 28 | 33 | 14 | 12

Figure S88. Get High-res Image Gene #213: 'CYTSB MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'CYTSB MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0472 (Fisher's exact test), Q value = 0.42

Table S639. Gene #213: 'CYTSB MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CYTSB MUTATED | 7 | 0 | 0 | 2 | 0 | 0 | 0
CYTSB WILD-TYPE | 27 | 11 | 9 | 5 | 6 | 20 | 9

Figure S89. Get High-res Image Gene #213: 'CYTSB MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'NAP1L5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.859 (Fisher's exact test), Q value = 0.94

Table S640. Gene #214: 'NAP1L5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NAP1L5 MUTATED | 2 | 1 | 0 | 1 | 0
NAP1L5 WILD-TYPE | 26 | 19 | 11 | 19 | 21

'NAP1L5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.395 (Fisher's exact test), Q value = 0.69

Table S641. Gene #214: 'NAP1L5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NAP1L5 MUTATED | 1 | 1 | 2 | 0
NAP1L5 WILD-TYPE | 34 | 32 | 14 | 12

'NAP1L5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.835 (Fisher's exact test), Q value = 0.94

Table S642. Gene #214: 'NAP1L5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NAP1L5 MUTATED | 2 | 0 | 0 | 1 | 0 | 1 | 0
NAP1L5 WILD-TYPE | 32 | 11 | 9 | 6 | 6 | 19 | 9

'DDX10 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.632 (Fisher's exact test), Q value = 0.84

Table S643. Gene #215: 'DDX10 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DDX10 MUTATED | 3 | 1 | 2 | 1 | 1
DDX10 WILD-TYPE | 25 | 19 | 9 | 19 | 20

'DDX10 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.352 (Fisher's exact test), Q value = 0.68

Table S644. Gene #215: 'DDX10 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DDX10 MUTATED | 4 | 1 | 2 | 0
DDX10 WILD-TYPE | 31 | 32 | 14 | 12

'DDX10 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.855 (Fisher's exact test), Q value = 0.94

Table S645. Gene #215: 'DDX10 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DDX10 MUTATED | 4 | 1 | 0 | 1 | 0 | 1 | 0
DDX10 WILD-TYPE | 30 | 10 | 9 | 6 | 6 | 19 | 9

'LIMK2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.844 (Fisher's exact test), Q value = 0.94

Table S646. Gene #216: 'LIMK2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LIMK2 MUTATED | 1 | 2 | 1 | 2 | 2
LIMK2 WILD-TYPE | 27 | 18 | 10 | 18 | 19

'LIMK2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.549 (Fisher's exact test), Q value = 0.77

Table S647. Gene #216: 'LIMK2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LIMK2 MUTATED | 5 | 2 | 1 | 0
LIMK2 WILD-TYPE | 30 | 31 | 15 | 12

'LIMK2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.641 (Fisher's exact test), Q value = 0.84

Table S648. Gene #216: 'LIMK2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LIMK2 MUTATED | 5 | 0 | 0 | 1 | 0 | 1 | 1
LIMK2 WILD-TYPE | 29 | 11 | 9 | 6 | 6 | 19 | 8

'POLD1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.871 (Fisher's exact test), Q value = 0.95

Table S649. Gene #217: 'POLD1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
POLD1 MUTATED | 1 | 1 | 1 | 1 | 2
POLD1 WILD-TYPE | 27 | 19 | 10 | 19 | 19

'POLD1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S650. Gene #217: 'POLD1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
POLD1 MUTATED | 2 | 2 | 1 | 1
POLD1 WILD-TYPE | 33 | 31 | 15 | 11

'POLD1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.55 (Fisher's exact test), Q value = 0.77

Table S651. Gene #217: 'POLD1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
POLD1 MUTATED | 2 | 0 | 0 | 1 | 1 | 1 | 1
POLD1 WILD-TYPE | 32 | 11 | 9 | 6 | 5 | 19 | 8

'SBNO1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0915 (Fisher's exact test), Q value = 0.47

Table S652. Gene #218: 'SBNO1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SBNO1 MUTATED | 0 | 3 | 1 | 1 | 4
SBNO1 WILD-TYPE | 28 | 17 | 10 | 19 | 17

'SBNO1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0384 (Fisher's exact test), Q value = 0.42

Table S653. Gene #218: 'SBNO1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SBNO1 MUTATED | 6 | 0 | 1 | 2
SBNO1 WILD-TYPE | 29 | 33 | 15 | 10

Figure S90. Get High-res Image Gene #218: 'SBNO1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'SBNO1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0921 (Fisher's exact test), Q value = 0.47

Table S654. Gene #218: 'SBNO1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SBNO1 MUTATED | 7 | 0 | 0 | 1 | 1 | 0 | 0
SBNO1 WILD-TYPE | 27 | 11 | 9 | 6 | 5 | 20 | 9

'CACHD1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.209 (Fisher's exact test), Q value = 0.58

Table S655. Gene #219: 'CACHD1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CACHD1 MUTATED | 2 | 0 | 1 | 0 | 3
CACHD1 WILD-TYPE | 26 | 20 | 10 | 20 | 18

'CACHD1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.11 (Fisher's exact test), Q value = 0.48

Table S656. Gene #219: 'CACHD1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CACHD1 MUTATED | 3 | 0 | 1 | 2
CACHD1 WILD-TYPE | 32 | 33 | 15 | 10

'CACHD1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.442 (Fisher's exact test), Q value = 0.72

Table S657. Gene #219: 'CACHD1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CACHD1 MUTATED | 4 | 1 | 0 | 0 | 1 | 0 | 0
CACHD1 WILD-TYPE | 30 | 10 | 9 | 7 | 5 | 20 | 9

'FAM200A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.203 (Fisher's exact test), Q value = 0.57

Table S658. Gene #220: 'FAM200A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FAM200A MUTATED | 0 | 2 | 1 | 1 | 0
FAM200A WILD-TYPE | 28 | 18 | 10 | 19 | 21

'FAM200A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.393 (Fisher's exact test), Q value = 0.69

Table S659. Gene #220: 'FAM200A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FAM200A MUTATED | 1 | 1 | 2 | 0
FAM200A WILD-TYPE | 34 | 32 | 14 | 12

'FAM200A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.213 (Fisher's exact test), Q value = 0.58

Table S660. Gene #220: 'FAM200A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FAM200A MUTATED | 1 | 0 | 0 | 2 | 0 | 1 | 0
FAM200A WILD-TYPE | 33 | 11 | 9 | 5 | 6 | 19 | 9

'KIAA1370 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.521 (Fisher's exact test), Q value = 0.76

Table S661. Gene #221: 'KIAA1370 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KIAA1370 MUTATED | 2 | 3 | 1 | 0 | 2
KIAA1370 WILD-TYPE | 26 | 17 | 10 | 20 | 19

'KIAA1370 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0314 (Fisher's exact test), Q value = 0.42

Table S662. Gene #221: 'KIAA1370 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KIAA1370 MUTATED | 5 | 0 | 3 | 0
KIAA1370 WILD-TYPE | 30 | 33 | 13 | 12

Figure S91. Get High-res Image Gene #221: 'KIAA1370 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'KIAA1370 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.136 (Fisher's exact test), Q value = 0.51

Table S663. Gene #221: 'KIAA1370 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KIAA1370 MUTATED | 5 | 0 | 0 | 2 | 0 | 0 | 1
KIAA1370 WILD-TYPE | 29 | 11 | 9 | 5 | 6 | 20 | 8

'C7ORF63 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.749 (Fisher's exact test), Q value = 0.9

Table S664. Gene #222: 'C7ORF63 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C7ORF63 MUTATED | 2 | 1 | 1 | 0 | 2
C7ORF63 WILD-TYPE | 26 | 19 | 10 | 20 | 19

'C7ORF63 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.16 (Fisher's exact test), Q value = 0.56

Table S665. Gene #222: 'C7ORF63 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C7ORF63 MUTATED | 3 | 0 | 2 | 0
C7ORF63 WILD-TYPE | 32 | 33 | 14 | 12

'C7ORF63 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.182 (Fisher's exact test), Q value = 0.56

Table S666. Gene #222: 'C7ORF63 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C7ORF63 MUTATED | 3 | 0 | 0 | 2 | 0 | 0 | 0
C7ORF63 WILD-TYPE | 31 | 11 | 9 | 5 | 6 | 20 | 9

'BAT3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.06 (Fisher's exact test), Q value = 0.45

Table S667. Gene #223: 'BAT3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
BAT3 MUTATED | 3 | 0 | 0 | 0 | 4
BAT3 WILD-TYPE | 25 | 20 | 11 | 20 | 17

'BAT3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0982 (Fisher's exact test), Q value = 0.48

Table S668. Gene #223: 'BAT3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
BAT3 MUTATED | 4 | 0 | 1 | 2
BAT3 WILD-TYPE | 31 | 33 | 15 | 10

'BAT3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0837 (Fisher's exact test), Q value = 0.47

Table S669. Gene #223: 'BAT3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
BAT3 MUTATED | 5 | 0 | 0 | 0 | 2 | 0 | 0
BAT3 WILD-TYPE | 29 | 11 | 9 | 7 | 4 | 20 | 9

'WNK4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.387 (Fisher's exact test), Q value = 0.68

Table S670. Gene #224: 'WNK4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
WNK4 MUTATED | 6 | 2 | 0 | 1 | 2
WNK4 WILD-TYPE | 22 | 18 | 11 | 19 | 19

'WNK4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.147 (Fisher's exact test), Q value = 0.54

Table S671. Gene #224: 'WNK4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
WNK4 MUTATED | 7 | 1 | 2 | 1
WNK4 WILD-TYPE | 28 | 32 | 14 | 11

'WNK4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0796 (Fisher's exact test), Q value = 0.47

Table S672. Gene #224: 'WNK4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
WNK4 MUTATED | 8 | 0 | 0 | 1 | 1 | 0 | 1
WNK4 WILD-TYPE | 26 | 11 | 9 | 6 | 5 | 20 | 8

'VPRBP MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.00322 (Fisher's exact test), Q value = 0.32

Table S673. Gene #225: 'VPRBP MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
VPRBP MUTATED | 0 | 5 | 0 | 0 | 1
VPRBP WILD-TYPE | 28 | 15 | 11 | 20 | 20

Figure S92. Get High-res Image Gene #225: 'VPRBP MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

'VPRBP MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.45 (Fisher's exact test), Q value = 0.73

Table S674. Gene #225: 'VPRBP MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
VPRBP MUTATED | 3 | 1 | 2 | 0
VPRBP WILD-TYPE | 32 | 32 | 14 | 12

'VPRBP MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.795 (Fisher's exact test), Q value = 0.92

Table S675. Gene #225: 'VPRBP MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
VPRBP MUTATED | 3 | 0 | 1 | 1 | 0 | 1 | 0
VPRBP WILD-TYPE | 31 | 11 | 8 | 6 | 6 | 19 | 9

'DOCK5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.377 (Fisher's exact test), Q value = 0.68

Table S676. Gene #226: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DOCK5 MUTATED | 0 | 2 | 1 | 2 | 2
DOCK5 WILD-TYPE | 28 | 18 | 10 | 18 | 19

'DOCK5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.819 (Fisher's exact test), Q value = 0.93

Table S677. Gene #226: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DOCK5 MUTATED | 3 | 1 | 1 | 1
DOCK5 WILD-TYPE | 32 | 32 | 15 | 11

'DOCK5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.606 (Fisher's exact test), Q value = 0.81

Table S678. Gene #226: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DOCK5 MUTATED | 3 | 0 | 0 | 1 | 1 | 1 | 0
DOCK5 WILD-TYPE | 31 | 11 | 9 | 6 | 5 | 19 | 9

'PPM1D MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.438 (Fisher's exact test), Q value = 0.72

Table S679. Gene #227: 'PPM1D MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PPM1D MUTATED | 4 | 1 | 1 | 0 | 1
PPM1D WILD-TYPE | 24 | 19 | 10 | 20 | 20

'PPM1D MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0898 (Fisher's exact test), Q value = 0.47

Table S680. Gene #227: 'PPM1D MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PPM1D MUTATED | 5 | 0 | 1 | 0
PPM1D WILD-TYPE | 30 | 33 | 15 | 12

'PPM1D MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.276 (Fisher's exact test), Q value = 0.63

Table S681. Gene #227: 'PPM1D MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PPM1D MUTATED | 5 | 0 | 0 | 1 | 0 | 0 | 0
PPM1D WILD-TYPE | 29 | 11 | 9 | 6 | 6 | 20 | 9

'MAPRE3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.784 (Fisher's exact test), Q value = 0.92

Table S682. Gene #228: 'MAPRE3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MAPRE3 MUTATED | 0 | 1 | 0 | 1 | 1
MAPRE3 WILD-TYPE | 28 | 19 | 11 | 19 | 20

'MAPRE3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.505 (Fisher's exact test), Q value = 0.75

Table S683. Gene #228: 'MAPRE3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MAPRE3 MUTATED | 2 | 0 | 1 | 0
MAPRE3 WILD-TYPE | 33 | 33 | 15 | 12

'MAPRE3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.52 (Fisher's exact test), Q value = 0.76

Table S684. Gene #228: 'MAPRE3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MAPRE3 MUTATED | 2 | 0 | 0 | 1 | 0 | 0 | 0
MAPRE3 WILD-TYPE | 32 | 11 | 9 | 6 | 6 | 20 | 9

'SHPRH MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.815 (Fisher's exact test), Q value = 0.93

Table S685. Gene #229: 'SHPRH MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SHPRH MUTATED | 3 | 1 | 2 | 2 | 2
SHPRH WILD-TYPE | 25 | 19 | 9 | 18 | 19

'SHPRH MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0293 (Fisher's exact test), Q value = 0.42

Table S686. Gene #229: 'SHPRH MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SHPRH MUTATED | 4 | 0 | 2 | 3
SHPRH WILD-TYPE | 31 | 33 | 14 | 9

Figure S93. Get High-res Image Gene #229: 'SHPRH MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'SHPRH MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0167 (Fisher's exact test), Q value = 0.4

Table S687. Gene #229: 'SHPRH MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SHPRH MUTATED | 5 | 0 | 0 | 1 | 3 | 0 | 0
SHPRH WILD-TYPE | 29 | 11 | 9 | 6 | 3 | 20 | 9

Figure S94. Get High-res Image Gene #229: 'SHPRH MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'KSR1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.208 (Fisher's exact test), Q value = 0.58

Table S688. Gene #230: 'KSR1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KSR1 MUTATED | 0 | 2 | 2 | 2 | 2
KSR1 WILD-TYPE | 28 | 18 | 9 | 18 | 19

'KSR1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.909 (Fisher's exact test), Q value = 0.98

Table S689. Gene #230: 'KSR1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KSR1 MUTATED | 3 | 2 | 2 | 1
KSR1 WILD-TYPE | 32 | 31 | 14 | 11

'KSR1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.641 (Fisher's exact test), Q value = 0.84

Table S690. Gene #230: 'KSR1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KSR1 MUTATED | 4 | 0 | 0 | 1 | 1 | 1 | 1
KSR1 WILD-TYPE | 30 | 11 | 9 | 6 | 5 | 19 | 8

'ZNF195 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.282 (Fisher's exact test), Q value = 0.64

Table S691. Gene #231: 'ZNF195 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZNF195 MUTATED | 1 | 3 | 1 | 0 | 2
ZNF195 WILD-TYPE | 27 | 17 | 10 | 20 | 19

'ZNF195 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0368 (Fisher's exact test), Q value = 0.42

Table S692. Gene #231: 'ZNF195 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZNF195 MUTATED | 6 | 0 | 1 | 0
ZNF195 WILD-TYPE | 29 | 33 | 15 | 12

Figure S95. Get High-res Image Gene #231: 'ZNF195 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'ZNF195 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.32 (Fisher's exact test), Q value = 0.65

Table S693. Gene #231: 'ZNF195 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZNF195 MUTATED | 5 | 0 | 1 | 1 | 0 | 0 | 0
ZNF195 WILD-TYPE | 29 | 11 | 8 | 6 | 6 | 20 | 9

'CANX MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.957 (Fisher's exact test), Q value = 1

Table S694. Gene #232: 'CANX MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CANX MUTATED | 1 | 1 | 1 | 1 | 1
CANX WILD-TYPE | 27 | 19 | 10 | 19 | 20

'CANX MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.264 (Fisher's exact test), Q value = 0.63

Table S695. Gene #232: 'CANX MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CANX MUTATED | 3 | 0 | 1 | 1
CANX WILD-TYPE | 32 | 33 | 15 | 11

'CANX MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.479 (Fisher's exact test), Q value = 0.75

Table S696. Gene #232: 'CANX MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CANX MUTATED | 3 | 1 | 0 | 0 | 1 | 0 | 0
CANX WILD-TYPE | 31 | 10 | 9 | 7 | 5 | 20 | 9

'WHSC1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.339 (Fisher's exact test), Q value = 0.67

Table S697. Gene #233: 'WHSC1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
WHSC1 MUTATED | 1 | 4 | 1 | 1 | 3
WHSC1 WILD-TYPE | 27 | 16 | 10 | 19 | 18

'WHSC1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0849 (Fisher's exact test), Q value = 0.47

Table S698. Gene #233: 'WHSC1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
WHSC1 MUTATED | 6 | 1 | 3 | 0
WHSC1 WILD-TYPE | 29 | 32 | 13 | 12

'WHSC1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.289 (Fisher's exact test), Q value = 0.64

Table S699. Gene #233: 'WHSC1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
WHSC1 MUTATED | 6 | 0 | 0 | 2 | 0 | 1 | 1
WHSC1 WILD-TYPE | 28 | 11 | 9 | 5 | 6 | 19 | 8

'TAOK3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.405 (Fisher's exact test), Q value = 0.69

Table S700. Gene #234: 'TAOK3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TAOK3 MUTATED | 2 | 1 | 2 | 0 | 1
TAOK3 WILD-TYPE | 26 | 19 | 9 | 20 | 20

'TAOK3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0532 (Fisher's exact test), Q value = 0.43

Table S701. Gene #234: 'TAOK3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TAOK3 MUTATED | 5 | 0 | 0 | 1
TAOK3 WILD-TYPE | 30 | 33 | 16 | 11

'TAOK3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.25 (Fisher's exact test), Q value = 0.63

Table S702. Gene #234: 'TAOK3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TAOK3 MUTATED | 5 | 0 | 0 | 0 | 1 | 0 | 0
TAOK3 WILD-TYPE | 29 | 11 | 9 | 7 | 5 | 20 | 9

'GIPC1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.856 (Fisher's exact test), Q value = 0.94

Table S703. Gene #235: 'GIPC1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
GIPC1 MUTATED | 1 | 1 | 0 | 1 | 0
GIPC1 WILD-TYPE | 27 | 19 | 11 | 19 | 21

'GIPC1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.862 (Fisher's exact test), Q value = 0.94

Table S704. Gene #235: 'GIPC1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
GIPC1 MUTATED | 1 | 1 | 1 | 0
GIPC1 WILD-TYPE | 34 | 32 | 15 | 12

'GIPC1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.368 (Fisher's exact test), Q value = 0.68

Table S705. Gene #235: 'GIPC1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
GIPC1 MUTATED | 1 | 0 | 0 | 1 | 0 | 0 | 1
GIPC1 WILD-TYPE | 33 | 11 | 9 | 6 | 6 | 20 | 8

'LOR MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.14 (Fisher's exact test), Q value = 0.52

Table S706. Gene #236: 'LOR MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LOR MUTATED | 3 | 0 | 1 | 0 | 0
LOR WILD-TYPE | 25 | 20 | 10 | 20 | 21

'LOR MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.319 (Fisher's exact test), Q value = 0.65

Table S707. Gene #236: 'LOR MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LOR MUTATED | 3 | 0 | 1 | 0
LOR WILD-TYPE | 32 | 33 | 15 | 12

'LOR MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.479 (Fisher's exact test), Q value = 0.75

Table S708. Gene #236: 'LOR MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LOR MUTATED | 3 | 0 | 0 | 1 | 0 | 0 | 0
LOR WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 20 | 9

'SMAP1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.696 (Fisher's exact test), Q value = 0.86

Table S709. Gene #237: 'SMAP1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SMAP1 MUTATED | 2 | 2 | 1 | 1 | 0
SMAP1 WILD-TYPE | 26 | 18 | 10 | 19 | 21

'SMAP1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0913 (Fisher's exact test), Q value = 0.47

Table S710. Gene #237: 'SMAP1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SMAP1 MUTATED | 5 | 0 | 1 | 0
SMAP1 WILD-TYPE | 30 | 33 | 15 | 12

'SMAP1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.276 (Fisher's exact test), Q value = 0.63

Table S711. Gene #237: 'SMAP1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SMAP1 MUTATED | 5 | 0 | 0 | 1 | 0 | 0 | 0
SMAP1 WILD-TYPE | 29 | 11 | 9 | 6 | 6 | 20 | 9

'HERC6 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.834 (Fisher's exact test), Q value = 0.94

Table S712. Gene #238: 'HERC6 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
HERC6 MUTATED | 2 | 1 | 1 | 0 | 1
HERC6 WILD-TYPE | 26 | 19 | 10 | 20 | 20

'HERC6 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.174 (Fisher's exact test), Q value = 0.56

Table S713. Gene #238: 'HERC6 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
HERC6 MUTATED | 4 | 0 | 1 | 0
HERC6 WILD-TYPE | 31 | 33 | 15 | 12

'HERC6 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.353 (Fisher's exact test), Q value = 0.68

Table S714. Gene #238: 'HERC6 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
HERC6 MUTATED | 5 | 0 | 0 | 0 | 0 | 0 | 0
HERC6 WILD-TYPE | 29 | 11 | 9 | 7 | 6 | 20 | 9

'KIAA0913 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.382 (Fisher's exact test), Q value = 0.68

Table S715. Gene #239: 'KIAA0913 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KIAA0913 MUTATED | 2 | 0 | 0 | 2 | 0
KIAA0913 WILD-TYPE | 26 | 20 | 11 | 18 | 21

'KIAA0913 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0159 (Fisher's exact test), Q value = 0.39

Table S716. Gene #239: 'KIAA0913 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KIAA0913 MUTATED | 0 | 1 | 3 | 0
KIAA0913 WILD-TYPE | 35 | 32 | 13 | 12

Figure S96. Get High-res Image Gene #239: 'KIAA0913 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'KIAA0913 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.211 (Fisher's exact test), Q value = 0.58

Table S717. Gene #239: 'KIAA0913 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KIAA0913 MUTATED | 1 | 0 | 0 | 2 | 0 | 1 | 0
KIAA0913 WILD-TYPE | 33 | 11 | 9 | 5 | 6 | 19 | 9

'FKBP11 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.288 (Fisher's exact test), Q value = 0.64

Table S718. Gene #240: 'FKBP11 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FKBP11 MUTATED | 0 | 1 | 0 | 0 | 2
FKBP11 WILD-TYPE | 28 | 19 | 11 | 20 | 19

'FKBP11 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.863 (Fisher's exact test), Q value = 0.94

Table S719. Gene #240: 'FKBP11 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FKBP11 MUTATED | 1 | 1 | 1 | 0
FKBP11 WILD-TYPE | 34 | 32 | 15 | 12

'FKBP11 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.369 (Fisher's exact test), Q value = 0.68

Table S720. Gene #240: 'FKBP11 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FKBP11 MUTATED | 1 | 0 | 0 | 1 | 0 | 0 | 1
FKBP11 WILD-TYPE | 33 | 11 | 9 | 6 | 6 | 20 | 8

'C5ORF36 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.623 (Fisher's exact test), Q value = 0.83

Table S721. Gene #241: 'C5ORF36 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C5ORF36 MUTATED | 1 | 3 | 1 | 1 | 2
C5ORF36 WILD-TYPE | 27 | 17 | 10 | 19 | 19

'C5ORF36 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0415 (Fisher's exact test), Q value = 0.42

Table S722. Gene #241: 'C5ORF36 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C5ORF36 MUTATED | 4 | 0 | 3 | 0
C5ORF36 WILD-TYPE | 31 | 33 | 13 | 12

Figure S97. Get High-res Image Gene #241: 'C5ORF36 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'C5ORF36 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.113 (Fisher's exact test), Q value = 0.48

Table S723. Gene #241: 'C5ORF36 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C5ORF36 MUTATED | 5 | 0 | 0 | 2 | 0 | 0 | 0
C5ORF36 WILD-TYPE | 29 | 11 | 9 | 5 | 6 | 20 | 9

'FAT2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.517 (Fisher's exact test), Q value = 0.76

Table S724. Gene #242: 'FAT2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FAT2 MUTATED | 5 | 4 | 1 | 1 | 5
FAT2 WILD-TYPE | 23 | 16 | 10 | 19 | 16

'FAT2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0497 (Fisher's exact test), Q value = 0.43

Table S725. Gene #242: 'FAT2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FAT2 MUTATED | 8 | 1 | 3 | 3
FAT2 WILD-TYPE | 27 | 32 | 13 | 9

Figure S98. Get High-res Image Gene #242: 'FAT2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'FAT2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0666 (Fisher's exact test), Q value = 0.45

Table S726. Gene #242: 'FAT2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FAT2 MUTATED | 9 | 0 | 1 | 2 | 2 | 1 | 0
FAT2 WILD-TYPE | 25 | 11 | 8 | 5 | 4 | 19 | 9

'XRRA1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0778 (Fisher's exact test), Q value = 0.47

Table S727. Gene #243: 'XRRA1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
XRRA1 MUTATED | 0 | 2 | 1 | 0 | 0
XRRA1 WILD-TYPE | 28 | 18 | 10 | 20 | 21

'XRRA1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.503 (Fisher's exact test), Q value = 0.75

Table S728. Gene #243: 'XRRA1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
XRRA1 MUTATED | 2 | 0 | 1 | 0
XRRA1 WILD-TYPE | 33 | 33 | 15 | 12

'XRRA1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.519 (Fisher's exact test), Q value = 0.76

Table S729. Gene #243: 'XRRA1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
XRRA1 MUTATED | 2 | 0 | 0 | 1 | 0 | 0 | 0
XRRA1 WILD-TYPE | 32 | 11 | 9 | 6 | 6 | 20 | 9

'ZNF583 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.82 (Fisher's exact test), Q value = 0.93

Table S730. Gene #244: 'ZNF583 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZNF583 MUTATED | 1 | 1 | 1 | 0 | 1
ZNF583 WILD-TYPE | 27 | 19 | 10 | 20 | 20

'ZNF583 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.35 (Fisher's exact test), Q value = 0.68

Table S731. Gene #244: 'ZNF583 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZNF583 MUTATED | 2 | 0 | 1 | 1
ZNF583 WILD-TYPE | 33 | 33 | 15 | 11

'ZNF583 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.312 (Fisher's exact test), Q value = 0.65

Table S732. Gene #244: 'ZNF583 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZNF583 MUTATED | 2 | 0 | 0 | 1 | 1 | 0 | 0
ZNF583 WILD-TYPE | 32 | 11 | 9 | 6 | 5 | 20 | 9

'FOXM1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.602 (Fisher's exact test), Q value = 0.81

Table S733. Gene #245: 'FOXM1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FOXM1 MUTATED | 1 | 2 | 0 | 1 | 3
FOXM1 WILD-TYPE | 27 | 18 | 11 | 19 | 18

'FOXM1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0225 (Fisher's exact test), Q value = 0.4

Table S734. Gene #245: 'FOXM1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FOXM1 MUTATED | 6 | 0 | 0 | 1
FOXM1 WILD-TYPE | 29 | 33 | 16 | 11

Figure S99. Get High-res Image Gene #245: 'FOXM1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'FOXM1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.147 (Fisher's exact test), Q value = 0.54

Table S735. Gene #245: 'FOXM1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FOXM1 MUTATED | 6 | 0 | 0 | 0 | 1 | 0 | 0
FOXM1 WILD-TYPE | 28 | 11 | 9 | 7 | 5 | 20 | 9

'INF2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0769 (Fisher's exact test), Q value = 0.47

Table S736. Gene #246: 'INF2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
INF2 MUTATED | 0 | 2 | 0 | 0 | 3
INF2 WILD-TYPE | 28 | 18 | 11 | 20 | 18

'INF2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.261 (Fisher's exact test), Q value = 0.63

Table S737. Gene #246: 'INF2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
INF2 MUTATED | 3 | 0 | 1 | 1
INF2 WILD-TYPE | 32 | 33 | 15 | 11

'INF2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.375 (Fisher's exact test), Q value = 0.68

Table S738. Gene #246: 'INF2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
INF2 MUTATED | 3 | 0 | 0 | 0 | 1 | 0 | 1
INF2 WILD-TYPE | 31 | 11 | 9 | 7 | 5 | 20 | 8

'SLC16A1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S739. Gene #247: 'SLC16A1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SLC16A1 MUTATED | 1 | 1 | 0 | 1 | 1
SLC16A1 WILD-TYPE | 27 | 19 | 11 | 19 | 20

'SLC16A1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.319 (Fisher's exact test), Q value = 0.65

Table S740. Gene #247: 'SLC16A1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SLC16A1 MUTATED | 3 | 0 | 1 | 0
SLC16A1 WILD-TYPE | 32 | 33 | 15 | 12

'SLC16A1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.482 (Fisher's exact test), Q value = 0.75

Table S741. Gene #247: 'SLC16A1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SLC16A1 MUTATED | 3 | 0 | 0 | 1 | 0 | 0 | 0
SLC16A1 WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 20 | 9

'SMAD7 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.923 (Fisher's exact test), Q value = 0.98

Table S742. Gene #248: 'SMAD7 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SMAD7 MUTATED | 1 | 1 | 0 | 1 | 2
SMAD7 WILD-TYPE | 27 | 19 | 11 | 19 | 19

'SMAD7 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.738 (Fisher's exact test), Q value = 0.89

Table S743. Gene #248: 'SMAD7 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SMAD7 MUTATED | 3 | 2 | 0 | 0
SMAD7 WILD-TYPE | 32 | 31 | 16 | 12

'SMAD7 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.869 (Fisher's exact test), Q value = 0.95

Table S744. Gene #248: 'SMAD7 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SMAD7 MUTATED | 2 | 0 | 0 | 0 | 0 | 2 | 1
SMAD7 WILD-TYPE | 32 | 11 | 9 | 7 | 6 | 18 | 8

'CELSR1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.654 (Fisher's exact test), Q value = 0.84

Table S745. Gene #249: 'CELSR1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CELSR1 MUTATED | 2 | 3 | 0 | 3 | 3
CELSR1 WILD-TYPE | 26 | 17 | 11 | 17 | 18

'CELSR1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0406 (Fisher's exact test), Q value = 0.42

Table S746. Gene #249: 'CELSR1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CELSR1 MUTATED | 8 | 1 | 2 | 0
CELSR1 WILD-TYPE | 27 | 32 | 14 | 12

Figure S100. Get High-res Image Gene #249: 'CELSR1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'CELSR1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0887 (Fisher's exact test), Q value = 0.47

Table S747. Gene #249: 'CELSR1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CELSR1 MUTATED | 8 | 0 | 0 | 2 | 0 | 1 | 0
CELSR1 WILD-TYPE | 26 | 11 | 9 | 5 | 6 | 19 | 9

'C14ORF43 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S748. Gene #250: 'C14ORF43 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C14ORF43 MUTATED | 1 | 1 | 0 | 1 | 1
C14ORF43 WILD-TYPE | 27 | 19 | 11 | 19 | 20

'C14ORF43 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.519 (Fisher's exact test), Q value = 0.76

Table S749. Gene #250: 'C14ORF43 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C14ORF43 MUTATED | 3 | 1 | 0 | 0
C14ORF43 WILD-TYPE | 32 | 32 | 16 | 12

'C14ORF43 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.962 (Fisher's exact test), Q value = 1

Table S750. Gene #250: 'C14ORF43 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C14ORF43 MUTATED | 3 | 0 | 0 | 0 | 0 | 1 | 0
C14ORF43 WILD-TYPE | 31 | 11 | 9 | 7 | 6 | 19 | 9

'SEC63 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0431 (Fisher's exact test), Q value = 0.42

Table S751. Gene #251: 'SEC63 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SEC63 MUTATED | 0 | 3 | 0 | 0 | 3
SEC63 WILD-TYPE | 28 | 17 | 11 | 20 | 18

Figure S101. Get High-res Image Gene #251: 'SEC63 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

'SEC63 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.568 (Fisher's exact test), Q value = 0.78

Table S752. Gene #251: 'SEC63 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SEC63 MUTATED | 2 | 1 | 2 | 1
SEC63 WILD-TYPE | 33 | 32 | 14 | 11

'SEC63 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.314 (Fisher's exact test), Q value = 0.65

Table S753. Gene #251: 'SEC63 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SEC63 MUTATED | 3 | 0 | 0 | 1 | 1 | 0 | 1
SEC63 WILD-TYPE | 31 | 11 | 9 | 6 | 5 | 20 | 8

'USP47 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.944 (Fisher's exact test), Q value = 0.99

Table S754. Gene #252: 'USP47 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
USP47 MUTATED | 2 | 2 | 0 | 1 | 1
USP47 WILD-TYPE | 26 | 18 | 11 | 19 | 20

'USP47 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0897 (Fisher's exact test), Q value = 0.47

Table S755. Gene #252: 'USP47 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
USP47 MUTATED | 5 | 0 | 1 | 0
USP47 WILD-TYPE | 30 | 33 | 15 | 12

'USP47 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.275 (Fisher's exact test), Q value = 0.63

Table S756. Gene #252: 'USP47 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
USP47 MUTATED | 5 | 0 | 0 | 1 | 0 | 0 | 0
USP47 WILD-TYPE | 29 | 11 | 9 | 6 | 6 | 20 | 9

'ZNF253 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.189 (Fisher's exact test), Q value = 0.56

Table S757. Gene #253: 'ZNF253 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZNF253 MUTATED | 0 | 3 | 0 | 1 | 2
ZNF253 WILD-TYPE | 28 | 17 | 11 | 19 | 19

'ZNF253 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.54 (Fisher's exact test), Q value = 0.77

Table S758. Gene #253: 'ZNF253 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZNF253 MUTATED | 4 | 1 | 1 | 0
ZNF253 WILD-TYPE | 31 | 32 | 15 | 12

'ZNF253 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.413 (Fisher's exact test), Q value = 0.69

Table S759. Gene #253: 'ZNF253 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZNF253 MUTATED | 4 | 0 | 0 | 1 | 0 | 0 | 1
ZNF253 WILD-TYPE | 30 | 11 | 9 | 6 | 6 | 20 | 8

'C1ORF141 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.256 (Fisher's exact test), Q value = 0.63

Table S760. Gene #254: 'C1ORF141 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C1ORF141 MUTATED | 1 | 1 | 2 | 0 | 2
C1ORF141 WILD-TYPE | 27 | 19 | 9 | 20 | 19

'C1ORF141 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.176 (Fisher's exact test), Q value = 0.56

Table S761. Gene #254: 'C1ORF141 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C1ORF141 MUTATED | 4 | 0 | 1 | 1
C1ORF141 WILD-TYPE | 31 | 33 | 15 | 11

'C1ORF141 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.274 (Fisher's exact test), Q value = 0.63

Table S762. Gene #254: 'C1ORF141 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C1ORF141 MUTATED | 4 | 0 | 0 | 1 | 1 | 0 | 0
C1ORF141 WILD-TYPE | 30 | 11 | 9 | 6 | 5 | 20 | 9

'COL5A1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.517 (Fisher's exact test), Q value = 0.76

Table S763. Gene #255: 'COL5A1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
COL5A1 MUTATED | 3 | 2 | 1 | 1 | 5
COL5A1 WILD-TYPE | 25 | 18 | 10 | 19 | 16

'COL5A1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0232 (Fisher's exact test), Q value = 0.4

Table S764. Gene #255: 'COL5A1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
COL5A1 MUTATED | 7 | 0 | 2 | 2
COL5A1 WILD-TYPE | 28 | 33 | 14 | 10

Figure S102. Get High-res Image Gene #255: 'COL5A1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'COL5A1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0973 (Fisher's exact test), Q value = 0.48

Table S765. Gene #255: 'COL5A1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
COL5A1 MUTATED | 8 | 1 | 0 | 1 | 1 | 0 | 0
COL5A1 WILD-TYPE | 26 | 10 | 9 | 6 | 5 | 20 | 9

'RAB3IL1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.589 (Fisher's exact test), Q value = 0.8

Table S766. Gene #256: 'RAB3IL1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RAB3IL1 MUTATED | 1 | 1 | 1 | 0 | 2
RAB3IL1 WILD-TYPE | 27 | 19 | 10 | 20 | 19

'RAB3IL1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.918 (Fisher's exact test), Q value = 0.98

Table S767. Gene #256: 'RAB3IL1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RAB3IL1 MUTATED | 2 | 2 | 0 | 1
RAB3IL1 WILD-TYPE | 33 | 31 | 16 | 11

'RAB3IL1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.179 (Fisher's exact test), Q value = 0.56

Table S768. Gene #256: 'RAB3IL1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RAB3IL1 MUTATED | 2 | 0 | 0 | 0 | 1 | 0 | 2
RAB3IL1 WILD-TYPE | 32 | 11 | 9 | 7 | 5 | 20 | 7

'C15ORF42 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.508 (Fisher's exact test), Q value = 0.75

Table S769. Gene #257: 'C15ORF42 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C15ORF42 MUTATED | 1 | 2 | 2 | 1 | 1
C15ORF42 WILD-TYPE | 27 | 18 | 9 | 19 | 20

'C15ORF42 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.316 (Fisher's exact test), Q value = 0.65

Table S770. Gene #257: 'C15ORF42 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C15ORF42 MUTATED | 2 | 2 | 3 | 0
C15ORF42 WILD-TYPE | 33 | 31 | 13 | 12

'C15ORF42 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.744 (Fisher's exact test), Q value = 0.89

Table S771. Gene #257: 'C15ORF42 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C15ORF42 MUTATED | 4 | 0 | 0 | 1 | 0 | 1 | 1
C15ORF42 WILD-TYPE | 30 | 11 | 9 | 6 | 6 | 19 | 8

'SPTY2D1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.114 (Fisher's exact test), Q value = 0.48

Table S772. Gene #258: 'SPTY2D1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SPTY2D1 MUTATED | 1 | 0 | 1 | 3 | 0
SPTY2D1 WILD-TYPE | 27 | 20 | 10 | 17 | 21

'SPTY2D1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.173 (Fisher's exact test), Q value = 0.56

Table S773. Gene #258: 'SPTY2D1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SPTY2D1 MUTATED | 4 | 0 | 1 | 0
SPTY2D1 WILD-TYPE | 31 | 33 | 15 | 12

'SPTY2D1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.383 (Fisher's exact test), Q value = 0.68

Table S774. Gene #258: 'SPTY2D1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SPTY2D1 MUTATED | 4 | 0 | 0 | 1 | 0 | 0 | 0
SPTY2D1 WILD-TYPE | 30 | 11 | 9 | 6 | 6 | 20 | 9

'C19ORF66 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.589 (Fisher's exact test), Q value = 0.8

Table S775. Gene #259: 'C19ORF66 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C19ORF66 MUTATED | 1 | 0 | 1 | 0 | 1
C19ORF66 WILD-TYPE | 27 | 20 | 10 | 20 | 20

'C19ORF66 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.382 (Fisher's exact test), Q value = 0.68

Table S776. Gene #259: 'C19ORF66 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C19ORF66 MUTATED | 2 | 0 | 0 | 1
C19ORF66 WILD-TYPE | 33 | 33 | 16 | 11

'C19ORF66 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.494 (Fisher's exact test), Q value = 0.75

Table S777. Gene #259: 'C19ORF66 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C19ORF66 MUTATED | 2 | 0 | 0 | 0 | 1 | 0 | 0
C19ORF66 WILD-TYPE | 32 | 11 | 9 | 7 | 5 | 20 | 9

'MYO1A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.792 (Fisher's exact test), Q value = 0.92

Table S778. Gene #260: 'MYO1A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MYO1A MUTATED | 2 | 3 | 1 | 1 | 3
MYO1A WILD-TYPE | 26 | 17 | 10 | 19 | 18

'MYO1A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0315 (Fisher's exact test), Q value = 0.42

Table S779. Gene #260: 'MYO1A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MYO1A MUTATED | 6 | 0 | 3 | 1
MYO1A WILD-TYPE | 29 | 33 | 13 | 11

Figure S103. Get High-res Image Gene #260: 'MYO1A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'MYO1A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.103 (Fisher's exact test), Q value = 0.48

Table S780. Gene #260: 'MYO1A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MYO1A MUTATED | 6 | 0 | 1 | 2 | 1 | 0 | 0
MYO1A WILD-TYPE | 28 | 11 | 8 | 5 | 5 | 20 | 9

'DMXL2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.352 (Fisher's exact test), Q value = 0.68

Table S781. Gene #261: 'DMXL2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DMXL2 MUTATED | 3 | 3 | 2 | 0 | 3
DMXL2 WILD-TYPE | 25 | 17 | 9 | 20 | 18

'DMXL2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0156 (Fisher's exact test), Q value = 0.39

Table S782. Gene #261: 'DMXL2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DMXL2 MUTATED | 8 | 0 | 2 | 1
DMXL2 WILD-TYPE | 27 | 33 | 14 | 11

Figure S104. Get High-res Image Gene #261: 'DMXL2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'DMXL2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0284 (Fisher's exact test), Q value = 0.42

Table S783. Gene #261: 'DMXL2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DMXL2 MUTATED | 8 | 0 | 0 | 2 | 1 | 0 | 0
DMXL2 WILD-TYPE | 26 | 11 | 9 | 5 | 5 | 20 | 9

Figure S105. Get High-res Image Gene #261: 'DMXL2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'ZIC5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.319 (Fisher's exact test), Q value = 0.65

Table S784. Gene #262: 'ZIC5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZIC5 MUTATED | 1 | 2 | 1 | 0 | 3
ZIC5 WILD-TYPE | 27 | 18 | 10 | 20 | 18

'ZIC5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.287 (Fisher's exact test), Q value = 0.64

Table S785. Gene #262: 'ZIC5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZIC5 MUTATED | 5 | 1 | 1 | 0
ZIC5 WILD-TYPE | 30 | 32 | 15 | 12

'ZIC5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.317 (Fisher's exact test), Q value = 0.65

Table S786. Gene #262: 'ZIC5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZIC5 MUTATED | 5 | 0 | 0 | 1 | 0 | 0 | 1
ZIC5 WILD-TYPE | 29 | 11 | 9 | 6 | 6 | 20 | 8

'DSC1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.652 (Fisher's exact test), Q value = 0.84

Table S787. Gene #263: 'DSC1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DSC1 MUTATED | 1 | 2 | 1 | 1 | 3
DSC1 WILD-TYPE | 27 | 18 | 10 | 19 | 18

'DSC1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.171 (Fisher's exact test), Q value = 0.56

Table S788. Gene #263: 'DSC1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DSC1 MUTATED | 6 | 1 | 1 | 0
DSC1 WILD-TYPE | 29 | 32 | 15 | 12

'DSC1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.214 (Fisher's exact test), Q value = 0.58

Table S789. Gene #263: 'DSC1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DSC1 MUTATED | 6 | 0 | 0 | 1 | 0 | 0 | 1
DSC1 WILD-TYPE | 28 | 11 | 9 | 6 | 6 | 20 | 8

'CCKBR MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.551 (Fisher's exact test), Q value = 0.77

Table S790. Gene #264: 'CCKBR MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CCKBR MUTATED | 0 | 1 | 1 | 1 | 1
CCKBR WILD-TYPE | 28 | 19 | 10 | 19 | 20

'CCKBR MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.355 (Fisher's exact test), Q value = 0.68

Table S791. Gene #264: 'CCKBR MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CCKBR MUTATED | 2 | 0 | 1 | 1
CCKBR WILD-TYPE | 33 | 33 | 15 | 11

'CCKBR MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.309 (Fisher's exact test), Q value = 0.65

Table S792. Gene #264: 'CCKBR MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CCKBR MUTATED | 2 | 0 | 0 | 1 | 1 | 0 | 0
CCKBR WILD-TYPE | 32 | 11 | 9 | 6 | 5 | 20 | 9

'QKI MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.858 (Fisher's exact test), Q value = 0.94

Table S793. Gene #265: 'QKI MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
QKI MUTATED | 2 | 1 | 0 | 1 | 0
QKI WILD-TYPE | 26 | 19 | 11 | 19 | 21

'QKI MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.351 (Fisher's exact test), Q value = 0.68

Table S794. Gene #265: 'QKI MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
QKI MUTATED | 2 | 0 | 1 | 1
QKI WILD-TYPE | 33 | 33 | 15 | 11

'QKI MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.4 (Fisher's exact test), Q value = 0.69

Table S795. Gene #265: 'QKI MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
QKI MUTATED | 3 | 0 | 0 | 0 | 1 | 0 | 0
QKI WILD-TYPE | 31 | 11 | 9 | 7 | 5 | 20 | 9

'DLGAP3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.616 (Fisher's exact test), Q value = 0.82

Table S796. Gene #266: 'DLGAP3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DLGAP3 MUTATED | 1 | 1 | 0 | 1 | 3
DLGAP3 WILD-TYPE | 27 | 19 | 11 | 19 | 18

'DLGAP3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.167 (Fisher's exact test), Q value = 0.56

Table S797. Gene #266: 'DLGAP3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DLGAP3 MUTATED | 3 | 0 | 2 | 1
DLGAP3 WILD-TYPE | 32 | 33 | 14 | 11

'DLGAP3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.279 (Fisher's exact test), Q value = 0.63

Table S798. Gene #266: 'DLGAP3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DLGAP3 MUTATED | 4 | 0 | 0 | 1 | 1 | 0 | 0
DLGAP3 WILD-TYPE | 30 | 11 | 9 | 6 | 5 | 20 | 9

'ZNF626 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.762 (Fisher's exact test), Q value = 0.9

Table S799. Gene #267: 'ZNF626 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZNF626 MUTATED | 3 | 2 | 0 | 1 | 3
ZNF626 WILD-TYPE | 25 | 18 | 11 | 19 | 18

'ZNF626 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.791 (Fisher's exact test), Q value = 0.92

Table S800. Gene #267: 'ZNF626 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZNF626 MUTATED | 4 | 3 | 2 | 0
ZNF626 WILD-TYPE | 31 | 30 | 14 | 12

'ZNF626 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.805 (Fisher's exact test), Q value = 0.93

Table S801. Gene #267: 'ZNF626 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZNF626 MUTATED | 5 | 0 | 0 | 1 | 0 | 2 | 1
ZNF626 WILD-TYPE | 29 | 11 | 9 | 6 | 6 | 18 | 8

'MGA MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.558 (Fisher's exact test), Q value = 0.78

Table S802. Gene #268: 'MGA MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MGA MUTATED | 4 | 3 | 1 | 1 | 5
MGA WILD-TYPE | 24 | 17 | 10 | 19 | 16

'MGA MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0771 (Fisher's exact test), Q value = 0.47

Table S803. Gene #268: 'MGA MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MGA MUTATED | 8 | 1 | 3 | 2
MGA WILD-TYPE | 27 | 32 | 13 | 10

'MGA MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0514 (Fisher's exact test), Q value = 0.43

Table S804. Gene #268: 'MGA MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MGA MUTATED | 7 | 0 | 1 | 3 | 2 | 1 | 0
MGA WILD-TYPE | 27 | 11 | 8 | 4 | 4 | 19 | 9

'C3ORF23 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.438 (Fisher's exact test), Q value = 0.72

Table S805. Gene #269: 'C3ORF23 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C3ORF23 MUTATED | 0 | 1 | 1 | 2 | 1
C3ORF23 WILD-TYPE | 28 | 19 | 10 | 18 | 20

'C3ORF23 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.522 (Fisher's exact test), Q value = 0.76

Table S806. Gene #269: 'C3ORF23 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C3ORF23 MUTATED | 3 | 1 | 0 | 1
C3ORF23 WILD-TYPE | 32 | 32 | 16 | 11

'C3ORF23 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.752 (Fisher's exact test), Q value = 0.9

Table S807. Gene #269: 'C3ORF23 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C3ORF23 MUTATED | 3 | 0 | 0 | 0 | 1 | 1 | 0
C3ORF23 WILD-TYPE | 31 | 11 | 9 | 7 | 5 | 19 | 9

'ALPPL2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.722 (Fisher's exact test), Q value = 0.88

Table S808. Gene #270: 'ALPPL2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ALPPL2 MUTATED | 2 | 2 | 0 | 0 | 1
ALPPL2 WILD-TYPE | 26 | 18 | 11 | 20 | 20

'ALPPL2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.733 (Fisher's exact test), Q value = 0.89

Table S809. Gene #270: 'ALPPL2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ALPPL2 MUTATED | 3 | 1 | 1 | 0
ALPPL2 WILD-TYPE | 32 | 32 | 15 | 12

'ALPPL2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.534 (Fisher's exact test), Q value = 0.77

Table S810. Gene #270: 'ALPPL2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ALPPL2 MUTATED | 4 | 0 | 0 | 0 | 0 | 0 | 1
ALPPL2 WILD-TYPE | 30 | 11 | 9 | 7 | 6 | 20 | 8

'EFHC1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.597 (Fisher's exact test), Q value = 0.8

Table S811. Gene #271: 'EFHC1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
EFHC1 MUTATED | 2 | 3 | 2 | 1 | 1
EFHC1 WILD-TYPE | 26 | 17 | 9 | 19 | 20

'EFHC1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0734 (Fisher's exact test), Q value = 0.47

Table S812. Gene #271: 'EFHC1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
EFHC1 MUTATED | 4 | 1 | 4 | 0
EFHC1 WILD-TYPE | 31 | 32 | 12 | 12

'EFHC1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0383 (Fisher's exact test), Q value = 0.42

Table S813. Gene #271: 'EFHC1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
EFHC1 MUTATED | 5 | 0 | 0 | 3 | 0 | 0 | 1
EFHC1 WILD-TYPE | 29 | 11 | 9 | 4 | 6 | 20 | 8

Figure S106. Get High-res Image Gene #271: 'EFHC1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'HNRNPA3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.665 (Fisher's exact test), Q value = 0.85

Table S814. Gene #272: 'HNRNPA3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
HNRNPA3 MUTATED | 1 | 2 | 0 | 0 | 1
HNRNPA3 WILD-TYPE | 27 | 18 | 11 | 20 | 20

'HNRNPA3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.508 (Fisher's exact test), Q value = 0.75

Table S815. Gene #272: 'HNRNPA3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
HNRNPA3 MUTATED | 2 | 0 | 1 | 0
HNRNPA3 WILD-TYPE | 33 | 33 | 15 | 12

'HNRNPA3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.696 (Fisher's exact test), Q value = 0.86

Table S816. Gene #272: 'HNRNPA3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
HNRNPA3 MUTATED | 3 | 0 | 0 | 0 | 0 | 0 | 0
HNRNPA3 WILD-TYPE | 31 | 11 | 9 | 7 | 6 | 20 | 9

'UBB MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.755 (Fisher's exact test), Q value = 0.9

Table S817. Gene #273: 'UBB MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
UBB MUTATED | 1 | 1 | 1 | 1 | 0
UBB WILD-TYPE | 27 | 19 | 10 | 19 | 21

'UBB MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0213 (Fisher's exact test), Q value = 0.4

Table S818. Gene #273: 'UBB MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
UBB MUTATED | 1 | 0 | 3 | 0
UBB WILD-TYPE | 34 | 33 | 13 | 12

Figure S107. Get High-res Image Gene #273: 'UBB MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'UBB MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.48 (Fisher's exact test), Q value = 0.75

Table S819. Gene #273: 'UBB MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
UBB MUTATED | 3 | 0 | 0 | 1 | 0 | 0 | 0
UBB WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 20 | 9

'SNX25 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.86 (Fisher's exact test), Q value = 0.94

Table S820. Gene #274: 'SNX25 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SNX25 MUTATED | 2 | 1 | 0 | 1 | 0
SNX25 WILD-TYPE | 26 | 19 | 11 | 19 | 21

'SNX25 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.122 (Fisher's exact test), Q value = 0.49

Table S821. Gene #274: 'SNX25 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SNX25 MUTATED | 4 | 0 | 0 | 0
SNX25 WILD-TYPE | 31 | 33 | 16 | 12

'SNX25 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.573 (Fisher's exact test), Q value = 0.78

Table S822. Gene #274: 'SNX25 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SNX25 MUTATED | 4 | 0 | 0 | 0 | 0 | 0 | 0
SNX25 WILD-TYPE | 30 | 11 | 9 | 7 | 6 | 20 | 9

'GDF7 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S823. Gene #275: 'GDF7 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
GDF7 MUTATED | 1 | 1 | 0 | 1 | 1
GDF7 WILD-TYPE | 27 | 19 | 11 | 19 | 20

'GDF7 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.722 (Fisher's exact test), Q value = 0.88

Table S824. Gene #275: 'GDF7 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
GDF7 MUTATED | 2 | 1 | 0 | 1
GDF7 WILD-TYPE | 33 | 32 | 16 | 11

'GDF7 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.623 (Fisher's exact test), Q value = 0.83

Table S825. Gene #275: 'GDF7 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
GDF7 MUTATED | 3 | 0 | 0 | 0 | 0 | 0 | 1
GDF7 WILD-TYPE | 31 | 11 | 9 | 7 | 6 | 20 | 8

'MFI2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.105 (Fisher's exact test), Q value = 0.48

Table S826. Gene #276: 'MFI2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MFI2 MUTATED | 1 | 0 | 2 | 0 | 2
MFI2 WILD-TYPE | 27 | 20 | 9 | 20 | 19

'MFI2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.189 (Fisher's exact test), Q value = 0.56

Table S827. Gene #276: 'MFI2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MFI2 MUTATED | 2 | 0 | 2 | 1
MFI2 WILD-TYPE | 33 | 33 | 14 | 11

'MFI2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.297 (Fisher's exact test), Q value = 0.65

Table S828. Gene #276: 'MFI2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MFI2 MUTATED | 3 | 0 | 0 | 1 | 1 | 0 | 0
MFI2 WILD-TYPE | 31 | 11 | 9 | 6 | 5 | 20 | 9

'AKT1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S829. Gene #277: 'AKT1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
AKT1 MUTATED | 1 | 1 | 0 | 1 | 1
AKT1 WILD-TYPE | 27 | 19 | 11 | 19 | 20

'AKT1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.38 (Fisher's exact test), Q value = 0.68

Table S830. Gene #277: 'AKT1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
AKT1 MUTATED | 2 | 0 | 0 | 1
AKT1 WILD-TYPE | 33 | 33 | 16 | 11

'AKT1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.494 (Fisher's exact test), Q value = 0.75

Table S831. Gene #277: 'AKT1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
AKT1 MUTATED | 2 | 0 | 0 | 0 | 1 | 0 | 0
AKT1 WILD-TYPE | 32 | 11 | 9 | 7 | 5 | 20 | 9

'DENND4C MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.937 (Fisher's exact test), Q value = 0.99

Table S832. Gene #278: 'DENND4C MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DENND4C MUTATED | 3 | 1 | 1 | 1 | 1
DENND4C WILD-TYPE | 25 | 19 | 10 | 19 | 20

'DENND4C MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0586 (Fisher's exact test), Q value = 0.45

Table S833. Gene #278: 'DENND4C MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DENND4C MUTATED | 5 | 0 | 2 | 0
DENND4C WILD-TYPE | 30 | 33 | 14 | 12

'DENND4C MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.176 (Fisher's exact test), Q value = 0.56

Table S834. Gene #278: 'DENND4C MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DENND4C MUTATED | 6 | 0 | 0 | 1 | 0 | 0 | 0
DENND4C WILD-TYPE | 28 | 11 | 9 | 6 | 6 | 20 | 9

'ACSM4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.94 (Fisher's exact test), Q value = 0.99

Table S835. Gene #279: 'ACSM4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ACSM4 MUTATED | 2 | 1 | 0 | 0 | 1
ACSM4 WILD-TYPE | 26 | 19 | 11 | 20 | 20

'ACSM4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S836. Gene #279: 'ACSM4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ACSM4 MUTATED | 2 | 1 | 1 | 0
ACSM4 WILD-TYPE | 33 | 32 | 15 | 12

'ACSM4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.52 (Fisher's exact test), Q value = 0.76

Table S837. Gene #279: 'ACSM4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ACSM4 MUTATED | 2 | 1 | 0 | 1 | 0 | 0 | 0
ACSM4 WILD-TYPE | 32 | 10 | 9 | 6 | 6 | 20 | 9

'TNRC18 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.523 (Fisher's exact test), Q value = 0.76

Table S838. Gene #280: 'TNRC18 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TNRC18 MUTATED | 2 | 1 | 0 | 2 | 4
TNRC18 WILD-TYPE | 26 | 19 | 11 | 18 | 17

'TNRC18 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.375 (Fisher's exact test), Q value = 0.68

Table S839. Gene #280: 'TNRC18 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TNRC18 MUTATED | 5 | 1 | 2 | 1
TNRC18 WILD-TYPE | 30 | 32 | 14 | 11

'TNRC18 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.105 (Fisher's exact test), Q value = 0.48

Table S840. Gene #280: 'TNRC18 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TNRC18 MUTATED | 6 | 0 | 0 | 2 | 0 | 0 | 1
TNRC18 WILD-TYPE | 28 | 11 | 9 | 5 | 6 | 20 | 8

'CACNA1F MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.922 (Fisher's exact test), Q value = 0.98

Table S841. Gene #281: 'CACNA1F MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CACNA1F MUTATED | 4 | 4 | 1 | 2 | 3
CACNA1F WILD-TYPE | 24 | 16 | 10 | 18 | 18

'CACNA1F MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00376 (Fisher's exact test), Q value = 0.32

Table S842. Gene #281: 'CACNA1F MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CACNA1F MUTATED | 7 | 0 | 5 | 1
CACNA1F WILD-TYPE | 28 | 33 | 11 | 11

Figure S108. Get High-res Image Gene #281: 'CACNA1F MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'CACNA1F MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0346 (Fisher's exact test), Q value = 0.42

Table S843. Gene #281: 'CACNA1F MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CACNA1F MUTATED | 9 | 1 | 0 | 2 | 1 | 0 | 0
CACNA1F WILD-TYPE | 25 | 10 | 9 | 5 | 5 | 20 | 9

Figure S109. Get High-res Image Gene #281: 'CACNA1F MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'RASA1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.136 (Fisher's exact test), Q value = 0.51

Table S844. Gene #282: 'RASA1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RASA1 MUTATED | 0 | 3 | 0 | 2 | 3
RASA1 WILD-TYPE | 28 | 17 | 11 | 18 | 18

'RASA1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0463 (Fisher's exact test), Q value = 0.42

Table S845. Gene #282: 'RASA1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RASA1 MUTATED | 6 | 0 | 1 | 1
RASA1 WILD-TYPE | 29 | 33 | 15 | 11

Figure S110. Get High-res Image Gene #282: 'RASA1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'RASA1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.213 (Fisher's exact test), Q value = 0.58

Table S846. Gene #282: 'RASA1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RASA1 MUTATED | 6 | 0 | 1 | 1 | 0 | 0 | 0
RASA1 WILD-TYPE | 28 | 11 | 8 | 6 | 6 | 20 | 9

'IRX5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0651 (Fisher's exact test), Q value = 0.45

Table S847. Gene #283: 'IRX5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
IRX5 MUTATED | 0 | 1 | 0 | 4 | 2
IRX5 WILD-TYPE | 28 | 19 | 11 | 16 | 19

'IRX5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.197 (Fisher's exact test), Q value = 0.57

Table S848. Gene #283: 'IRX5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
IRX5 MUTATED | 5 | 1 | 0 | 1
IRX5 WILD-TYPE | 30 | 32 | 16 | 11

'IRX5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.688 (Fisher's exact test), Q value = 0.86

Table S849. Gene #283: 'IRX5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
IRX5 MUTATED | 4 | 0 | 1 | 0 | 1 | 1 | 0
IRX5 WILD-TYPE | 30 | 11 | 8 | 7 | 5 | 19 | 9

'TBX10 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.855 (Fisher's exact test), Q value = 0.94

Table S850. Gene #284: 'TBX10 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TBX10 MUTATED | 1 | 1 | 0 | 1 | 0
TBX10 WILD-TYPE | 27 | 19 | 11 | 19 | 21

'TBX10 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S851. Gene #284: 'TBX10 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TBX10 MUTATED | 2 | 1 | 0 | 0
TBX10 WILD-TYPE | 33 | 32 | 16 | 12

'TBX10 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.653 (Fisher's exact test), Q value = 0.84

Table S852. Gene #284: 'TBX10 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TBX10 MUTATED | 2 | 0 | 0 | 0 | 0 | 0 | 1
TBX10 WILD-TYPE | 32 | 11 | 9 | 7 | 6 | 20 | 8

'PRIC285 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.691 (Fisher's exact test), Q value = 0.86

Table S853. Gene #285: 'PRIC285 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PRIC285 MUTATED | 3 | 2 | 1 | 5 | 3
PRIC285 WILD-TYPE | 25 | 18 | 10 | 15 | 18

'PRIC285 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0517 (Fisher's exact test), Q value = 0.43

Table S854. Gene #285: 'PRIC285 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PRIC285 MUTATED | 8 | 1 | 2 | 3
PRIC285 WILD-TYPE | 27 | 32 | 14 | 9

'PRIC285 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0407 (Fisher's exact test), Q value = 0.42

Table S855. Gene #285: 'PRIC285 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PRIC285 MUTATED | 9 | 2 | 0 | 0 | 2 | 0 | 1
PRIC285 WILD-TYPE | 25 | 9 | 9 | 7 | 4 | 20 | 8

Figure S111. Get High-res Image Gene #285: 'PRIC285 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'MAX MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.484 (Fisher's exact test), Q value = 0.75

Table S856. Gene #286: 'MAX MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MAX MUTATED | 2 | 0 | 1 | 1 | 0
MAX WILD-TYPE | 26 | 20 | 10 | 19 | 21

'MAX MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S857. Gene #286: 'MAX MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MAX MUTATED | 2 | 1 | 1 | 0
MAX WILD-TYPE | 33 | 32 | 15 | 12

'MAX MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.834 (Fisher's exact test), Q value = 0.94

Table S858. Gene #286: 'MAX MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MAX MUTATED | 2 | 0 | 0 | 1 | 0 | 1 | 0
MAX WILD-TYPE | 32 | 11 | 9 | 6 | 6 | 19 | 9

'IQSEC2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.925 (Fisher's exact test), Q value = 0.98

Table S859. Gene #287: 'IQSEC2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
IQSEC2 MUTATED | 4 | 1 | 1 | 2 | 3
IQSEC2 WILD-TYPE | 24 | 19 | 10 | 18 | 18

'IQSEC2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.164 (Fisher's exact test), Q value = 0.56

Table S860. Gene #287: 'IQSEC2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
IQSEC2 MUTATED | 6 | 1 | 3 | 1
IQSEC2 WILD-TYPE | 29 | 32 | 13 | 11

'IQSEC2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.154 (Fisher's exact test), Q value = 0.55

Table S861. Gene #287: 'IQSEC2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
IQSEC2 MUTATED | 7 | 0 | 0 | 2 | 1 | 1 | 0
IQSEC2 WILD-TYPE | 27 | 11 | 9 | 5 | 5 | 19 | 9

'KIAA1804 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.229 (Fisher's exact test), Q value = 0.6

Table S862. Gene #288: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KIAA1804 MUTATED | 0 | 3 | 1 | 1 | 2
KIAA1804 WILD-TYPE | 28 | 17 | 10 | 19 | 19

'KIAA1804 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.406 (Fisher's exact test), Q value = 0.69

Table S863. Gene #288: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KIAA1804 MUTATED | 3 | 1 | 1 | 2
KIAA1804 WILD-TYPE | 32 | 32 | 15 | 10

'KIAA1804 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.114 (Fisher's exact test), Q value = 0.48

Table S864. Gene #288: 'KIAA1804 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KIAA1804 MUTATED | 2 | 1 | 0 | 1 | 2 | 0 | 1
KIAA1804 WILD-TYPE | 32 | 10 | 9 | 6 | 4 | 20 | 8

'IPO9 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.924 (Fisher's exact test), Q value = 0.98

Table S865. Gene #289: 'IPO9 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
IPO9 MUTATED | 1 | 1 | 0 | 1 | 2
IPO9 WILD-TYPE | 27 | 19 | 11 | 19 | 19

'IPO9 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.367 (Fisher's exact test), Q value = 0.68

Table S866. Gene #289: 'IPO9 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
IPO9 MUTATED | 4 | 1 | 0 | 0
IPO9 WILD-TYPE | 31 | 32 | 16 | 12

'IPO9 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.588 (Fisher's exact test), Q value = 0.8

Table S867. Gene #289: 'IPO9 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
IPO9 MUTATED | 3 | 0 | 1 | 0 | 0 | 0 | 1
IPO9 WILD-TYPE | 31 | 11 | 8 | 7 | 6 | 20 | 8

'TPP2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.305 (Fisher's exact test), Q value = 0.65

Table S868. Gene #290: 'TPP2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TPP2 MUTATED | 2 | 3 | 0 | 0 | 3
TPP2 WILD-TYPE | 26 | 17 | 11 | 20 | 18

'TPP2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0748 (Fisher's exact test), Q value = 0.47

Table S869. Gene #290: 'TPP2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TPP2 MUTATED | 4 | 0 | 2 | 2
TPP2 WILD-TYPE | 31 | 33 | 14 | 10

'TPP2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0796 (Fisher's exact test), Q value = 0.47

Table S870. Gene #290: 'TPP2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TPP2 MUTATED | 5 | 0 | 0 | 1 | 2 | 0 | 0
TPP2 WILD-TYPE | 29 | 11 | 9 | 6 | 4 | 20 | 9

'CDC73 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.485 (Fisher's exact test), Q value = 0.75

Table S871. Gene #291: 'CDC73 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CDC73 MUTATED | 2 | 1 | 1 | 0 | 3
CDC73 WILD-TYPE | 26 | 19 | 10 | 20 | 18

'CDC73 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.256 (Fisher's exact test), Q value = 0.63

Table S872. Gene #291: 'CDC73 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CDC73 MUTATED | 2 | 1 | 2 | 2
CDC73 WILD-TYPE | 33 | 32 | 14 | 10

'CDC73 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.251 (Fisher's exact test), Q value = 0.63

Table S873. Gene #291: 'CDC73 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CDC73 MUTATED | 4 | 0 | 0 | 0 | 2 | 1 | 0
CDC73 WILD-TYPE | 30 | 11 | 9 | 7 | 4 | 19 | 9

'HRASLS5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.959 (Fisher's exact test), Q value = 1

Table S874. Gene #292: 'HRASLS5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
HRASLS5 MUTATED | 1 | 1 | 1 | 1 | 1
HRASLS5 WILD-TYPE | 27 | 19 | 10 | 19 | 20

'HRASLS5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.162 (Fisher's exact test), Q value = 0.56

Table S875. Gene #292: 'HRASLS5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
HRASLS5 MUTATED | 3 | 0 | 2 | 0
HRASLS5 WILD-TYPE | 32 | 33 | 14 | 12

'HRASLS5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.183 (Fisher's exact test), Q value = 0.56

Table S876. Gene #292: 'HRASLS5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
HRASLS5 MUTATED | 3 | 0 | 0 | 2 | 0 | 0 | 0
HRASLS5 WILD-TYPE | 31 | 11 | 9 | 5 | 6 | 20 | 9

'ARID4B MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.56 (Fisher's exact test), Q value = 0.78

Table S877. Gene #293: 'ARID4B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ARID4B MUTATED | 1 | 3 | 0 | 1 | 1
ARID4B WILD-TYPE | 27 | 17 | 11 | 19 | 20

'ARID4B MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.74 (Fisher's exact test), Q value = 0.89

Table S878. Gene #293: 'ARID4B MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ARID4B MUTATED | 3 | 1 | 1 | 0
ARID4B WILD-TYPE | 32 | 32 | 15 | 12

'ARID4B MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.452 (Fisher's exact test), Q value = 0.73

Table S879. Gene #293: 'ARID4B MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ARID4B MUTATED | 3 | 0 | 0 | 1 | 0 | 0 | 1
ARID4B WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 20 | 8

'SLC2A5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.833 (Fisher's exact test), Q value = 0.94

Table S880. Gene #294: 'SLC2A5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SLC2A5 MUTATED | 2 | 1 | 1 | 0 | 1
SLC2A5 WILD-TYPE | 26 | 19 | 10 | 20 | 20

'SLC2A5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.114 (Fisher's exact test), Q value = 0.48

Table S881. Gene #294: 'SLC2A5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SLC2A5 MUTATED | 1 | 1 | 3 | 0
SLC2A5 WILD-TYPE | 34 | 32 | 13 | 12

'SLC2A5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.473 (Fisher's exact test), Q value = 0.75

Table S882. Gene #294: 'SLC2A5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SLC2A5 MUTATED | 2 | 1 | 0 | 1 | 0 | 0 | 1
SLC2A5 WILD-TYPE | 32 | 10 | 9 | 6 | 6 | 20 | 8

'TUBB4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.768 (Fisher's exact test), Q value = 0.91

Table S883. Gene #295: 'TUBB4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TUBB4 MUTATED | 1 | 2 | 0 | 2 | 1
TUBB4 WILD-TYPE | 27 | 18 | 11 | 18 | 20

'TUBB4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0907 (Fisher's exact test), Q value = 0.47

Table S884. Gene #295: 'TUBB4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TUBB4 MUTATED | 5 | 0 | 1 | 0
TUBB4 WILD-TYPE | 30 | 33 | 15 | 12

'TUBB4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.412 (Fisher's exact test), Q value = 0.69

Table S885. Gene #295: 'TUBB4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TUBB4 MUTATED | 4 | 0 | 0 | 1 | 0 | 0 | 1
TUBB4 WILD-TYPE | 30 | 11 | 9 | 6 | 6 | 20 | 8

'ARID3B MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0788 (Fisher's exact test), Q value = 0.47

Table S886. Gene #296: 'ARID3B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ARID3B MUTATED | 0 | 1 | 0 | 1 | 4
ARID3B WILD-TYPE | 28 | 19 | 11 | 19 | 17

'ARID3B MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.345 (Fisher's exact test), Q value = 0.68

Table S887. Gene #296: 'ARID3B MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ARID3B MUTATED | 4 | 1 | 0 | 1
ARID3B WILD-TYPE | 31 | 32 | 16 | 11

'ARID3B MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.369 (Fisher's exact test), Q value = 0.68

Table S888. Gene #296: 'ARID3B MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ARID3B MUTATED | 5 | 0 | 0 | 0 | 0 | 0 | 1
ARID3B WILD-TYPE | 29 | 11 | 9 | 7 | 6 | 20 | 8

'AADACL3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.246 (Fisher's exact test), Q value = 0.63

Table S889. Gene #297: 'AADACL3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
AADACL3 MUTATED | 0 | 1 | 1 | 0 | 2
AADACL3 WILD-TYPE | 28 | 19 | 10 | 20 | 19

'AADACL3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.352 (Fisher's exact test), Q value = 0.68

Table S890. Gene #297: 'AADACL3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
AADACL3 MUTATED | 2 | 0 | 1 | 1
AADACL3 WILD-TYPE | 33 | 33 | 15 | 11

'AADACL3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.309 (Fisher's exact test), Q value = 0.65

Table S891. Gene #297: 'AADACL3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
AADACL3 MUTATED | 2 | 0 | 0 | 1 | 1 | 0 | 0
AADACL3 WILD-TYPE | 32 | 11 | 9 | 6 | 5 | 20 | 9

'TXNDC11 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.454 (Fisher's exact test), Q value = 0.73

Table S892. Gene #298: 'TXNDC11 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TXNDC11 MUTATED | 2 | 1 | 0 | 0 | 3
TXNDC11 WILD-TYPE | 26 | 19 | 11 | 20 | 18

'TXNDC11 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0523 (Fisher's exact test), Q value = 0.43

Table S893. Gene #298: 'TXNDC11 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TXNDC11 MUTATED | 5 | 0 | 0 | 1
TXNDC11 WILD-TYPE | 30 | 33 | 16 | 11

'TXNDC11 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.252 (Fisher's exact test), Q value = 0.63

Table S894. Gene #298: 'TXNDC11 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TXNDC11 MUTATED | 5 | 0 | 0 | 0 | 1 | 0 | 0
TXNDC11 WILD-TYPE | 29 | 11 | 9 | 7 | 5 | 20 | 9

'TULP4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.197 (Fisher's exact test), Q value = 0.57

Table S895. Gene #299: 'TULP4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TULP4 MUTATED | 0 | 1 | 2 | 2 | 2
TULP4 WILD-TYPE | 28 | 19 | 9 | 18 | 19

'TULP4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.132 (Fisher's exact test), Q value = 0.51

Table S896. Gene #299: 'TULP4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TULP4 MUTATED | 4 | 0 | 2 | 1
TULP4 WILD-TYPE | 31 | 33 | 14 | 11

'TULP4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.114 (Fisher's exact test), Q value = 0.48

Table S897. Gene #299: 'TULP4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TULP4 MUTATED | 4 | 0 | 0 | 2 | 1 | 0 | 0
TULP4 WILD-TYPE | 30 | 11 | 9 | 5 | 5 | 20 | 9

'CALB1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.642 (Fisher's exact test), Q value = 0.84

Table S898. Gene #300: 'CALB1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CALB1 MUTATED | 3 | 1 | 0 | 0 | 1
CALB1 WILD-TYPE | 25 | 19 | 11 | 20 | 20

'CALB1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.738 (Fisher's exact test), Q value = 0.89

Table S899. Gene #300: 'CALB1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CALB1 MUTATED | 3 | 1 | 1 | 0
CALB1 WILD-TYPE | 32 | 32 | 15 | 12

'CALB1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.638 (Fisher's exact test), Q value = 0.84

Table S900. Gene #300: 'CALB1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CALB1 MUTATED | 3 | 1 | 0 | 0 | 0 | 0 | 1
CALB1 WILD-TYPE | 31 | 10 | 9 | 7 | 6 | 20 | 8

'OXER1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.734 (Fisher's exact test), Q value = 0.89

Table S901. Gene #301: 'OXER1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
OXER1 MUTATED | 2 | 0 | 0 | 0 | 1
OXER1 WILD-TYPE | 26 | 20 | 11 | 20 | 20

'OXER1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.282 (Fisher's exact test), Q value = 0.64

Table S902. Gene #301: 'OXER1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
OXER1 MUTATED | 3 | 0 | 0 | 0
OXER1 WILD-TYPE | 32 | 33 | 16 | 12

'OXER1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.697 (Fisher's exact test), Q value = 0.86

Table S903. Gene #301: 'OXER1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
OXER1 MUTATED | 3 | 0 | 0 | 0 | 0 | 0 | 0
OXER1 WILD-TYPE | 31 | 11 | 9 | 7 | 6 | 20 | 9

'BCLAF1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.782 (Fisher's exact test), Q value = 0.92

Table S904. Gene #302: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
BCLAF1 MUTATED | 2 | 2 | 2 | 1 | 2
BCLAF1 WILD-TYPE | 26 | 18 | 9 | 19 | 19

'BCLAF1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.363 (Fisher's exact test), Q value = 0.68

Table S905. Gene #302: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
BCLAF1 MUTATED | 6 | 2 | 1 | 0
BCLAF1 WILD-TYPE | 29 | 31 | 15 | 12

'BCLAF1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.524 (Fisher's exact test), Q value = 0.76

Table S906. Gene #302: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
BCLAF1 MUTATED | 5 | 1 | 1 | 1 | 0 | 0 | 1
BCLAF1 WILD-TYPE | 29 | 10 | 8 | 6 | 6 | 20 | 8

'IDH3A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.82 (Fisher's exact test), Q value = 0.93

Table S907. Gene #303: 'IDH3A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
IDH3A MUTATED | 1 | 0 | 1 | 1 | 1
IDH3A WILD-TYPE | 27 | 20 | 10 | 19 | 20

'IDH3A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.319 (Fisher's exact test), Q value = 0.65

Table S908. Gene #303: 'IDH3A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
IDH3A MUTATED | 3 | 0 | 1 | 0
IDH3A WILD-TYPE | 32 | 33 | 15 | 12

'IDH3A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.48 (Fisher's exact test), Q value = 0.75

Table S909. Gene #303: 'IDH3A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
IDH3A MUTATED | 3 | 0 | 0 | 1 | 0 | 0 | 0
IDH3A WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 20 | 9

'SYNM MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S910. Gene #304: 'SYNM MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SYNM MUTATED | 1 | 1 | 0 | 0 | 1
SYNM WILD-TYPE | 27 | 19 | 11 | 20 | 20

'SYNM MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.504 (Fisher's exact test), Q value = 0.75

Table S911. Gene #304: 'SYNM MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SYNM MUTATED | 2 | 0 | 1 | 0
SYNM WILD-TYPE | 33 | 33 | 15 | 12

'SYNM MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.521 (Fisher's exact test), Q value = 0.76

Table S912. Gene #304: 'SYNM MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SYNM MUTATED | 2 | 0 | 0 | 1 | 0 | 0 | 0
SYNM WILD-TYPE | 32 | 11 | 9 | 6 | 6 | 20 | 9

'C20ORF194 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.663 (Fisher's exact test), Q value = 0.85

Table S913. Gene #305: 'C20ORF194 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C20ORF194 MUTATED | 1 | 2 | 0 | 0 | 1
C20ORF194 WILD-TYPE | 27 | 18 | 11 | 20 | 20

'C20ORF194 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S914. Gene #305: 'C20ORF194 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C20ORF194 MUTATED | 2 | 2 | 0 | 0
C20ORF194 WILD-TYPE | 33 | 31 | 16 | 12

'C20ORF194 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.674 (Fisher's exact test), Q value = 0.85

Table S915. Gene #305: 'C20ORF194 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C20ORF194 MUTATED | 2 | 1 | 0 | 0 | 0 | 0 | 1
C20ORF194 WILD-TYPE | 32 | 10 | 9 | 7 | 6 | 20 | 8

'FRG1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.979 (Fisher's exact test), Q value = 1

Table S916. Gene #306: 'FRG1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FRG1 MUTATED | 2 | 2 | 1 | 1 | 1
FRG1 WILD-TYPE | 26 | 18 | 10 | 19 | 20

'FRG1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.109 (Fisher's exact test), Q value = 0.48

Table S917. Gene #306: 'FRG1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FRG1 MUTATED | 5 | 0 | 1 | 1
FRG1 WILD-TYPE | 30 | 33 | 15 | 11

'FRG1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.209 (Fisher's exact test), Q value = 0.58

Table S918. Gene #306: 'FRG1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FRG1 MUTATED | 5 | 0 | 0 | 1 | 1 | 0 | 0
FRG1 WILD-TYPE | 29 | 11 | 9 | 6 | 5 | 20 | 9

'DOCK9 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.321 (Fisher's exact test), Q value = 0.65

Table S919. Gene #307: 'DOCK9 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DOCK9 MUTATED | 1 | 2 | 0 | 1 | 4
DOCK9 WILD-TYPE | 27 | 18 | 11 | 19 | 17

'DOCK9 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.411 (Fisher's exact test), Q value = 0.69

Table S920. Gene #307: 'DOCK9 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DOCK9 MUTATED | 5 | 1 | 1 | 1
DOCK9 WILD-TYPE | 30 | 32 | 15 | 11

'DOCK9 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.261 (Fisher's exact test), Q value = 0.63

Table S921. Gene #307: 'DOCK9 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DOCK9 MUTATED | 5 | 0 | 0 | 1 | 1 | 0 | 1
DOCK9 WILD-TYPE | 29 | 11 | 9 | 6 | 5 | 20 | 8

'LMOD2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.642 (Fisher's exact test), Q value = 0.84

Table S922. Gene #308: 'LMOD2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LMOD2 MUTATED | 2 | 2 | 0 | 0 | 2
LMOD2 WILD-TYPE | 26 | 18 | 11 | 20 | 19

'LMOD2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.365 (Fisher's exact test), Q value = 0.68

Table S923. Gene #308: 'LMOD2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LMOD2 MUTATED | 4 | 1 | 0 | 0
LMOD2 WILD-TYPE | 31 | 32 | 16 | 12

'LMOD2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.904 (Fisher's exact test), Q value = 0.97

Table S924. Gene #308: 'LMOD2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LMOD2 MUTATED | 3 | 0 | 0 | 0 | 0 | 1 | 1
LMOD2 WILD-TYPE | 31 | 11 | 9 | 7 | 6 | 19 | 8

'IGF2R MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.601 (Fisher's exact test), Q value = 0.81

Table S925. Gene #309: 'IGF2R MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
IGF2R MUTATED | 3 | 1 | 1 | 1 | 4
IGF2R WILD-TYPE | 25 | 19 | 10 | 19 | 17

'IGF2R MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.131 (Fisher's exact test), Q value = 0.51

Table S926. Gene #309: 'IGF2R MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
IGF2R MUTATED | 7 | 1 | 1 | 1
IGF2R WILD-TYPE | 28 | 32 | 15 | 11

'IGF2R MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.14 (Fisher's exact test), Q value = 0.52

Table S927. Gene #309: 'IGF2R MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
IGF2R MUTATED | 8 | 0 | 0 | 0 | 1 | 1 | 0
IGF2R WILD-TYPE | 26 | 11 | 9 | 7 | 5 | 19 | 9

'POTEE MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.169 (Fisher's exact test), Q value = 0.56

Table S928. Gene #310: 'POTEE MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
POTEE MUTATED | 2 | 0 | 2 | 0 | 1
POTEE WILD-TYPE | 26 | 20 | 9 | 20 | 20

'POTEE MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.517 (Fisher's exact test), Q value = 0.76

Table S929. Gene #310: 'POTEE MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
POTEE MUTATED | 3 | 1 | 0 | 0
POTEE WILD-TYPE | 32 | 32 | 16 | 12

'POTEE MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.963 (Fisher's exact test), Q value = 1

Table S930. Gene #310: 'POTEE MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
POTEE MUTATED | 3 | 0 | 0 | 0 | 0 | 1 | 0
POTEE WILD-TYPE | 31 | 11 | 9 | 7 | 6 | 19 | 9

'N4BP2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.138 (Fisher's exact test), Q value = 0.52

Table S931. Gene #311: 'N4BP2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
N4BP2 MUTATED | 1 | 5 | 2 | 1 | 2
N4BP2 WILD-TYPE | 27 | 15 | 9 | 19 | 19

'N4BP2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.406 (Fisher's exact test), Q value = 0.69

Table S932. Gene #311: 'N4BP2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
N4BP2 MUTATED | 6 | 2 | 1 | 2
N4BP2 WILD-TYPE | 29 | 31 | 15 | 10

'N4BP2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.262 (Fisher's exact test), Q value = 0.63

Table S933. Gene #311: 'N4BP2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
N4BP2 MUTATED | 5 | 1 | 1 | 1 | 2 | 0 | 1
N4BP2 WILD-TYPE | 29 | 10 | 8 | 6 | 4 | 20 | 8

'RUFY2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.892 (Fisher's exact test), Q value = 0.97

Table S934. Gene #312: 'RUFY2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RUFY2 MUTATED | 1 | 2 | 0 | 1 | 1
RUFY2 WILD-TYPE | 27 | 18 | 11 | 19 | 20

'RUFY2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0469 (Fisher's exact test), Q value = 0.42

Table S935. Gene #312: 'RUFY2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RUFY2 MUTATED | 5 | 0 | 0 | 0
RUFY2 WILD-TYPE | 30 | 33 | 16 | 12

Figure S112. Get High-res Image Gene #312: 'RUFY2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'RUFY2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.352 (Fisher's exact test), Q value = 0.68

Table S936. Gene #312: 'RUFY2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RUFY2 MUTATED | 5 | 0 | 0 | 0 | 0 | 0 | 0
RUFY2 WILD-TYPE | 29 | 11 | 9 | 7 | 6 | 20 | 9

'UBQLN2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.348 (Fisher's exact test), Q value = 0.68

Table S937. Gene #313: 'UBQLN2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
UBQLN2 MUTATED | 1 | 1 | 1 | 0 | 3
UBQLN2 WILD-TYPE | 27 | 19 | 10 | 20 | 18

'UBQLN2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.104 (Fisher's exact test), Q value = 0.48

Table S938. Gene #313: 'UBQLN2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
UBQLN2 MUTATED | 4 | 0 | 2 | 0
UBQLN2 WILD-TYPE | 31 | 33 | 14 | 12

'UBQLN2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.193 (Fisher's exact test), Q value = 0.56

Table S939. Gene #313: 'UBQLN2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
UBQLN2 MUTATED | 6 | 0 | 0 | 0 | 0 | 0 | 0
UBQLN2 WILD-TYPE | 28 | 11 | 9 | 7 | 6 | 20 | 9

'PIGB MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.694 (Fisher's exact test), Q value = 0.86

Table S940. Gene #314: 'PIGB MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PIGB MUTATED | 2 | 2 | 1 | 1 | 0
PIGB WILD-TYPE | 26 | 18 | 10 | 19 | 21

'PIGB MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.177 (Fisher's exact test), Q value = 0.56

Table S941. Gene #314: 'PIGB MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PIGB MUTATED | 4 | 0 | 1 | 1
PIGB WILD-TYPE | 31 | 33 | 15 | 11

'PIGB MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.247 (Fisher's exact test), Q value = 0.63

Table S942. Gene #314: 'PIGB MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PIGB MUTATED | 5 | 0 | 0 | 0 | 1 | 0 | 0
PIGB WILD-TYPE | 29 | 11 | 9 | 7 | 5 | 20 | 9

'TSPAN10 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.783 (Fisher's exact test), Q value = 0.92

Table S943. Gene #315: 'TSPAN10 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TSPAN10 MUTATED | 0 | 1 | 0 | 1 | 1
TSPAN10 WILD-TYPE | 28 | 19 | 11 | 19 | 20

'TSPAN10 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S944. Gene #315: 'TSPAN10 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TSPAN10 MUTATED | 2 | 1 | 0 | 0
TSPAN10 WILD-TYPE | 33 | 32 | 16 | 12

'TSPAN10 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.821 (Fisher's exact test), Q value = 0.93

Table S945. Gene #315: 'TSPAN10 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TSPAN10 MUTATED | 2 | 1 | 0 | 0 | 0 | 0 | 0
TSPAN10 WILD-TYPE | 32 | 10 | 9 | 7 | 6 | 20 | 9

'SFRS8 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.392 (Fisher's exact test), Q value = 0.69

Table S946. Gene #316: 'SFRS8 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SFRS8 MUTATED | 2 | 3 | 0 | 1 | 0
SFRS8 WILD-TYPE | 26 | 17 | 11 | 19 | 21

'SFRS8 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.45 (Fisher's exact test), Q value = 0.73

Table S947. Gene #316: 'SFRS8 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SFRS8 MUTATED | 3 | 1 | 2 | 0
SFRS8 WILD-TYPE | 32 | 32 | 14 | 12

'SFRS8 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.855 (Fisher's exact test), Q value = 0.94

Table S948. Gene #316: 'SFRS8 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SFRS8 MUTATED | 4 | 0 | 0 | 0 | 0 | 1 | 1
SFRS8 WILD-TYPE | 30 | 11 | 9 | 7 | 6 | 19 | 8

'TSTD2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.303 (Fisher's exact test), Q value = 0.65

Table S949. Gene #317: 'TSTD2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TSTD2 MUTATED | 1 | 2 | 0 | 0 | 3
TSTD2 WILD-TYPE | 27 | 18 | 11 | 20 | 18

'TSTD2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0898 (Fisher's exact test), Q value = 0.47

Table S950. Gene #317: 'TSTD2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TSTD2 MUTATED | 5 | 0 | 1 | 0
TSTD2 WILD-TYPE | 30 | 33 | 15 | 12

'TSTD2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.194 (Fisher's exact test), Q value = 0.56

Table S951. Gene #317: 'TSTD2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TSTD2 MUTATED | 6 | 0 | 0 | 0 | 0 | 0 | 0
TSTD2 WILD-TYPE | 28 | 11 | 9 | 7 | 6 | 20 | 9

'WDR5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.131 (Fisher's exact test), Q value = 0.51

Table S952. Gene #318: 'WDR5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
WDR5 MUTATED | 1 | 0 | 2 | 0 | 1
WDR5 WILD-TYPE | 27 | 20 | 9 | 20 | 20

'WDR5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.507 (Fisher's exact test), Q value = 0.75

Table S953. Gene #318: 'WDR5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
WDR5 MUTATED | 2 | 0 | 1 | 0
WDR5 WILD-TYPE | 33 | 33 | 15 | 12

'WDR5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.52 (Fisher's exact test), Q value = 0.76

Table S954. Gene #318: 'WDR5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
WDR5 MUTATED | 2 | 0 | 0 | 1 | 0 | 0 | 0
WDR5 WILD-TYPE | 32 | 11 | 9 | 6 | 6 | 20 | 9

'LPIN1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0856 (Fisher's exact test), Q value = 0.47

Table S955. Gene #319: 'LPIN1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LPIN1 MUTATED | 0 | 3 | 1 | 0 | 1
LPIN1 WILD-TYPE | 28 | 17 | 10 | 20 | 20

'LPIN1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.182 (Fisher's exact test), Q value = 0.56

Table S956. Gene #319: 'LPIN1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LPIN1 MUTATED | 2 | 0 | 2 | 0
LPIN1 WILD-TYPE | 33 | 33 | 14 | 12

'LPIN1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.158 (Fisher's exact test), Q value = 0.56

Table S957. Gene #319: 'LPIN1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LPIN1 MUTATED | 2 | 0 | 0 | 2 | 0 | 0 | 0
LPIN1 WILD-TYPE | 32 | 11 | 9 | 5 | 6 | 20 | 9

'OR2A4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S958. Gene #320: 'OR2A4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
OR2A4 MUTATED | 1 | 0 | 0 | 1 | 1
OR2A4 WILD-TYPE | 27 | 20 | 11 | 19 | 20

'OR2A4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.286 (Fisher's exact test), Q value = 0.64

Table S959. Gene #320: 'OR2A4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
OR2A4 MUTATED | 3 | 0 | 0 | 0
OR2A4 WILD-TYPE | 32 | 33 | 16 | 12

'OR2A4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.696 (Fisher's exact test), Q value = 0.86

Table S960. Gene #320: 'OR2A4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
OR2A4 MUTATED | 3 | 0 | 0 | 0 | 0 | 0 | 0
OR2A4 WILD-TYPE | 31 | 11 | 9 | 7 | 6 | 20 | 9

'RAPGEF4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.256 (Fisher's exact test), Q value = 0.63

Table S961. Gene #321: 'RAPGEF4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RAPGEF4 MUTATED | 3 | 3 | 0 | 3 | 0
RAPGEF4 WILD-TYPE | 25 | 17 | 11 | 17 | 21

'RAPGEF4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0302 (Fisher's exact test), Q value = 0.42

Table S962. Gene #321: 'RAPGEF4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RAPGEF4 MUTATED | 5 | 0 | 3 | 0
RAPGEF4 WILD-TYPE | 30 | 33 | 13 | 12

Figure S113. Get High-res Image Gene #321: 'RAPGEF4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'RAPGEF4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.214 (Fisher's exact test), Q value = 0.58

Table S963. Gene #321: 'RAPGEF4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RAPGEF4 MUTATED | 6 | 0 | 1 | 1 | 0 | 0 | 0
RAPGEF4 WILD-TYPE | 28 | 11 | 8 | 6 | 6 | 20 | 9

'KCNA4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.647 (Fisher's exact test), Q value = 0.84

Table S964. Gene #322: 'KCNA4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KCNA4 MUTATED | 1 | 3 | 1 | 2 | 2
KCNA4 WILD-TYPE | 27 | 17 | 10 | 18 | 19

'KCNA4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.361 (Fisher's exact test), Q value = 0.68

Table S965. Gene #322: 'KCNA4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KCNA4 MUTATED | 6 | 2 | 1 | 0
KCNA4 WILD-TYPE | 29 | 31 | 15 | 12

'KCNA4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.326 (Fisher's exact test), Q value = 0.66

Table S966. Gene #322: 'KCNA4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KCNA4 MUTATED | 6 | 1 | 0 | 1 | 0 | 0 | 1
KCNA4 WILD-TYPE | 28 | 10 | 9 | 6 | 6 | 20 | 8

'LYSMD1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S967. Gene #323: 'LYSMD1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LYSMD1 MUTATED | 1 | 1 | 0 | 0 | 1
LYSMD1 WILD-TYPE | 27 | 19 | 11 | 20 | 20

'LYSMD1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.384 (Fisher's exact test), Q value = 0.68

Table S968. Gene #323: 'LYSMD1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LYSMD1 MUTATED | 2 | 0 | 0 | 1
LYSMD1 WILD-TYPE | 33 | 33 | 16 | 11

'LYSMD1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.693 (Fisher's exact test), Q value = 0.86

Table S969. Gene #323: 'LYSMD1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LYSMD1 MUTATED | 3 | 0 | 0 | 0 | 0 | 0 | 0
LYSMD1 WILD-TYPE | 31 | 11 | 9 | 7 | 6 | 20 | 9

'MYH4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.118 (Fisher's exact test), Q value = 0.49

Table S970. Gene #324: 'MYH4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MYH4 MUTATED | 0 | 3 | 0 | 1 | 3
MYH4 WILD-TYPE | 28 | 17 | 11 | 19 | 18

'MYH4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.548 (Fisher's exact test), Q value = 0.77

Table S971. Gene #324: 'MYH4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MYH4 MUTATED | 3 | 1 | 2 | 1
MYH4 WILD-TYPE | 32 | 32 | 14 | 11

'MYH4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.318 (Fisher's exact test), Q value = 0.65

Table S972. Gene #324: 'MYH4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MYH4 MUTATED | 4 | 0 | 0 | 1 | 1 | 0 | 1
MYH4 WILD-TYPE | 30 | 11 | 9 | 6 | 5 | 20 | 8

'SEMA6C MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S973. Gene #325: 'SEMA6C MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SEMA6C MUTATED | 2 | 1 | 1 | 1 | 1
SEMA6C WILD-TYPE | 26 | 19 | 10 | 19 | 20

'SEMA6C MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.178 (Fisher's exact test), Q value = 0.56

Table S974. Gene #325: 'SEMA6C MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SEMA6C MUTATED | 4 | 0 | 1 | 1
SEMA6C WILD-TYPE | 31 | 33 | 15 | 11

'SEMA6C MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.248 (Fisher's exact test), Q value = 0.63

Table S975. Gene #325: 'SEMA6C MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SEMA6C MUTATED | 5 | 0 | 0 | 0 | 1 | 0 | 0
SEMA6C WILD-TYPE | 29 | 11 | 9 | 7 | 5 | 20 | 9

'LIMCH1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.93 (Fisher's exact test), Q value = 0.99

Table S976. Gene #326: 'LIMCH1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LIMCH1 MUTATED | 3 | 2 | 1 | 1 | 1
LIMCH1 WILD-TYPE | 25 | 18 | 10 | 19 | 20

'LIMCH1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.55 (Fisher's exact test), Q value = 0.77

Table S977. Gene #326: 'LIMCH1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LIMCH1 MUTATED | 5 | 2 | 1 | 0
LIMCH1 WILD-TYPE | 30 | 31 | 15 | 12

'LIMCH1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.691 (Fisher's exact test), Q value = 0.86

Table S978. Gene #326: 'LIMCH1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LIMCH1 MUTATED | 5 | 0 | 0 | 1 | 0 | 2 | 0
LIMCH1 WILD-TYPE | 29 | 11 | 9 | 6 | 6 | 18 | 9

'CTSA MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0641 (Fisher's exact test), Q value = 0.45

Table S979. Gene #327: 'CTSA MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CTSA MUTATED | 0 | 0 | 2 | 1 | 1
CTSA WILD-TYPE | 28 | 20 | 9 | 19 | 20

'CTSA MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0543 (Fisher's exact test), Q value = 0.43

Table S980. Gene #327: 'CTSA MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CTSA MUTATED | 1 | 0 | 1 | 2
CTSA WILD-TYPE | 34 | 33 | 15 | 10

'CTSA MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0371 (Fisher's exact test), Q value = 0.42

Table S981. Gene #327: 'CTSA MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CTSA MUTATED | 1 | 0 | 0 | 1 | 2 | 0 | 0
CTSA WILD-TYPE | 33 | 11 | 9 | 6 | 4 | 20 | 9

Figure S114. Get High-res Image Gene #327: 'CTSA MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'MAP3K4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.92 (Fisher's exact test), Q value = 0.98

Table S982. Gene #328: 'MAP3K4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MAP3K4 MUTATED | 5 | 3 | 1 | 2 | 2
MAP3K4 WILD-TYPE | 23 | 17 | 10 | 18 | 19

'MAP3K4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0438 (Fisher's exact test), Q value = 0.42

Table S983. Gene #328: 'MAP3K4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MAP3K4 MUTATED | 9 | 1 | 2 | 1
MAP3K4 WILD-TYPE | 26 | 32 | 14 | 11

Figure S115. Get High-res Image Gene #328: 'MAP3K4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'MAP3K4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0377 (Fisher's exact test), Q value = 0.42

Table S984. Gene #328: 'MAP3K4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MAP3K4 MUTATED | 9 | 0 | 0 | 1 | 1 | 0 | 2
MAP3K4 WILD-TYPE | 25 | 11 | 9 | 6 | 5 | 20 | 7

Figure S116. Get High-res Image Gene #328: 'MAP3K4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'SGK1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.664 (Fisher's exact test), Q value = 0.85

Table S985. Gene #329: 'SGK1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SGK1 MUTATED | 1 | 2 | 0 | 0 | 1
SGK1 WILD-TYPE | 27 | 18 | 11 | 20 | 20

'SGK1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.32 (Fisher's exact test), Q value = 0.65

Table S986. Gene #329: 'SGK1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SGK1 MUTATED | 3 | 0 | 1 | 0
SGK1 WILD-TYPE | 32 | 33 | 15 | 12

'SGK1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.389 (Fisher's exact test), Q value = 0.68

Table S987. Gene #329: 'SGK1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SGK1 MUTATED | 2 | 0 | 1 | 1 | 0 | 0 | 0
SGK1 WILD-TYPE | 32 | 11 | 8 | 6 | 6 | 20 | 9

'NFE2L1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0788 (Fisher's exact test), Q value = 0.47

Table S988. Gene #330: 'NFE2L1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NFE2L1 MUTATED | 0 | 0 | 1 | 2 | 0
NFE2L1 WILD-TYPE | 28 | 20 | 10 | 18 | 21

'NFE2L1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.861 (Fisher's exact test), Q value = 0.94

Table S989. Gene #330: 'NFE2L1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NFE2L1 MUTATED | 1 | 1 | 1 | 0
NFE2L1 WILD-TYPE | 34 | 32 | 15 | 12

'NFE2L1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.186 (Fisher's exact test), Q value = 0.56

Table S990. Gene #330: 'NFE2L1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NFE2L1 MUTATED | 0 | 0 | 1 | 1 | 0 | 1 | 0
NFE2L1 WILD-TYPE | 34 | 11 | 8 | 6 | 6 | 19 | 9

'WASF3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.119 (Fisher's exact test), Q value = 0.49

Table S991. Gene #331: 'WASF3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
WASF3 MUTATED | 0 | 3 | 0 | 1 | 3
WASF3 WILD-TYPE | 28 | 17 | 11 | 19 | 18

'WASF3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0899 (Fisher's exact test), Q value = 0.47

Table S992. Gene #331: 'WASF3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
WASF3 MUTATED | 3 | 0 | 2 | 2
WASF3 WILD-TYPE | 32 | 33 | 14 | 10

'WASF3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0375 (Fisher's exact test), Q value = 0.42

Table S993. Gene #331: 'WASF3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
WASF3 MUTATED | 3 | 0 | 0 | 2 | 2 | 0 | 0
WASF3 WILD-TYPE | 31 | 11 | 9 | 5 | 4 | 20 | 9

Figure S117. Get High-res Image Gene #331: 'WASF3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'ARNTL MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S994. Gene #332: 'ARNTL MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ARNTL MUTATED | 2 | 1 | 0 | 1 | 1
ARNTL WILD-TYPE | 26 | 19 | 11 | 19 | 20

'ARNTL MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0462 (Fisher's exact test), Q value = 0.42

Table S995. Gene #332: 'ARNTL MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ARNTL MUTATED | 5 | 0 | 0 | 0
ARNTL WILD-TYPE | 30 | 33 | 16 | 12

Figure S118. Get High-res Image Gene #332: 'ARNTL MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'ARNTL MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.533 (Fisher's exact test), Q value = 0.77

Table S996. Gene #332: 'ARNTL MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ARNTL MUTATED | 4 | 0 | 1 | 0 | 0 | 0 | 0
ARNTL WILD-TYPE | 30 | 11 | 8 | 7 | 6 | 20 | 9

'EDC4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.279 (Fisher's exact test), Q value = 0.63

Table S997. Gene #333: 'EDC4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
EDC4 MUTATED | 1 | 2 | 1 | 0 | 0
EDC4 WILD-TYPE | 27 | 18 | 10 | 20 | 21

'EDC4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.517 (Fisher's exact test), Q value = 0.76

Table S998. Gene #333: 'EDC4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
EDC4 MUTATED | 3 | 1 | 0 | 0
EDC4 WILD-TYPE | 32 | 32 | 16 | 12

'EDC4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.146 (Fisher's exact test), Q value = 0.53

Table S999. Gene #333: 'EDC4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
EDC4 MUTATED | 1 | 0 | 1 | 0 | 0 | 0 | 2
EDC4 WILD-TYPE | 33 | 11 | 8 | 7 | 6 | 20 | 7

'TBC1D22A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0796 (Fisher's exact test), Q value = 0.47

Table S1000. Gene #334: 'TBC1D22A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TBC1D22A MUTATED | 0 | 2 | 0 | 0 | 3
TBC1D22A WILD-TYPE | 28 | 18 | 11 | 20 | 18

'TBC1D22A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.736 (Fisher's exact test), Q value = 0.89

Table S1001. Gene #334: 'TBC1D22A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TBC1D22A MUTATED | 3 | 1 | 1 | 0
TBC1D22A WILD-TYPE | 32 | 32 | 15 | 12

'TBC1D22A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.453 (Fisher's exact test), Q value = 0.73

Table S1002. Gene #334: 'TBC1D22A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TBC1D22A MUTATED | 3 | 0 | 0 | 1 | 0 | 0 | 1
TBC1D22A WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 20 | 8

'ALPK1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0232 (Fisher's exact test), Q value = 0.4

Table S1003. Gene #335: 'ALPK1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ALPK1 MUTATED | 0 | 3 | 1 | 0 | 4
ALPK1 WILD-TYPE | 28 | 17 | 10 | 20 | 17

Figure S119. Get High-res Image Gene #335: 'ALPK1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

'ALPK1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0106 (Fisher's exact test), Q value = 0.39

Table S1004. Gene #335: 'ALPK1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ALPK1 MUTATED | 7 | 0 | 0 | 1
ALPK1 WILD-TYPE | 28 | 33 | 16 | 11

Figure S120. Get High-res Image Gene #335: 'ALPK1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'ALPK1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.124 (Fisher's exact test), Q value = 0.5

Table S1005. Gene #335: 'ALPK1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ALPK1 MUTATED | 7 | 0 | 0 | 0 | 0 | 0 | 1
ALPK1 WILD-TYPE | 27 | 11 | 9 | 7 | 6 | 20 | 8

'SYTL2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.275 (Fisher's exact test), Q value = 0.63

Table S1006. Gene #336: 'SYTL2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SYTL2 MUTATED | 1 | 1 | 2 | 0 | 1
SYTL2 WILD-TYPE | 27 | 19 | 9 | 20 | 20

'SYTL2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.266 (Fisher's exact test), Q value = 0.63

Table S1007. Gene #336: 'SYTL2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SYTL2 MUTATED | 3 | 0 | 1 | 1
SYTL2 WILD-TYPE | 32 | 33 | 15 | 11

'SYTL2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.355 (Fisher's exact test), Q value = 0.68

Table S1008. Gene #336: 'SYTL2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SYTL2 MUTATED | 4 | 0 | 0 | 0 | 1 | 0 | 0
SYTL2 WILD-TYPE | 30 | 11 | 9 | 7 | 5 | 20 | 9

'OAT MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0439 (Fisher's exact test), Q value = 0.42

Table S1009. Gene #337: 'OAT MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
OAT MUTATED | 0 | 0 | 0 | 0 | 3
OAT WILD-TYPE | 28 | 20 | 11 | 20 | 18

Figure S121. Get High-res Image Gene #337: 'OAT MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

'OAT MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0548 (Fisher's exact test), Q value = 0.43

Table S1010. Gene #337: 'OAT MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
OAT MUTATED | 1 | 0 | 0 | 2
OAT WILD-TYPE | 34 | 33 | 16 | 10

'OAT MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0612 (Fisher's exact test), Q value = 0.45

Table S1011. Gene #337: 'OAT MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
OAT MUTATED | 1 | 0 | 0 | 0 | 2 | 0 | 0
OAT WILD-TYPE | 33 | 11 | 9 | 7 | 4 | 20 | 9

'HSP90B1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.743 (Fisher's exact test), Q value = 0.89

Table S1012. Gene #338: 'HSP90B1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
HSP90B1 MUTATED | 2 | 3 | 0 | 1 | 1
HSP90B1 WILD-TYPE | 26 | 17 | 11 | 19 | 20

'HSP90B1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0607 (Fisher's exact test), Q value = 0.45

Table S1013. Gene #338: 'HSP90B1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
HSP90B1 MUTATED | 5 | 0 | 2 | 0
HSP90B1 WILD-TYPE | 30 | 33 | 14 | 12

'HSP90B1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.159 (Fisher's exact test), Q value = 0.56

Table S1014. Gene #338: 'HSP90B1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
HSP90B1 MUTATED | 4 | 0 | 1 | 2 | 0 | 0 | 0
HSP90B1 WILD-TYPE | 30 | 11 | 8 | 5 | 6 | 20 | 9

'PTCH1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.925 (Fisher's exact test), Q value = 0.98

Table S1015. Gene #339: 'PTCH1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PTCH1 MUTATED | 2 | 2 | 1 | 1 | 3
PTCH1 WILD-TYPE | 26 | 18 | 10 | 19 | 18

'PTCH1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0227 (Fisher's exact test), Q value = 0.4

Table S1016. Gene #339: 'PTCH1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PTCH1 MUTATED | 4 | 0 | 4 | 1
PTCH1 WILD-TYPE | 31 | 33 | 12 | 11

Figure S122. Get High-res Image Gene #339: 'PTCH1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'PTCH1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.069 (Fisher's exact test), Q value = 0.46

Table S1017. Gene #339: 'PTCH1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PTCH1 MUTATED | 6 | 0 | 0 | 2 | 1 | 0 | 0
PTCH1 WILD-TYPE | 28 | 11 | 9 | 5 | 5 | 20 | 9

'SULT1E1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.21 (Fisher's exact test), Q value = 0.58

Table S1018. Gene #340: 'SULT1E1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SULT1E1 MUTATED | 0 | 2 | 0 | 0 | 1
SULT1E1 WILD-TYPE | 28 | 18 | 11 | 20 | 20

'SULT1E1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.285 (Fisher's exact test), Q value = 0.64

Table S1019. Gene #340: 'SULT1E1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SULT1E1 MUTATED | 3 | 0 | 0 | 0
SULT1E1 WILD-TYPE | 32 | 33 | 16 | 12

'SULT1E1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.649 (Fisher's exact test), Q value = 0.84

Table S1020. Gene #340: 'SULT1E1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SULT1E1 MUTATED | 2 | 0 | 1 | 0 | 0 | 0 | 0
SULT1E1 WILD-TYPE | 32 | 11 | 8 | 7 | 6 | 20 | 9

'UPF3A MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.209 (Fisher's exact test), Q value = 0.58

Table S1021. Gene #341: 'UPF3A MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
UPF3A MUTATED | 2 | 0 | 0 | 0 | 3
UPF3A WILD-TYPE | 26 | 20 | 11 | 20 | 18

'UPF3A MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.103 (Fisher's exact test), Q value = 0.48

Table S1022. Gene #341: 'UPF3A MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
UPF3A MUTATED | 2 | 0 | 1 | 2
UPF3A WILD-TYPE | 33 | 33 | 15 | 10

'UPF3A MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.127 (Fisher's exact test), Q value = 0.5

Table S1023. Gene #341: 'UPF3A MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
UPF3A MUTATED | 3 | 0 | 0 | 0 | 2 | 0 | 0
UPF3A WILD-TYPE | 31 | 11 | 9 | 7 | 4 | 20 | 9

'DNAH8 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.221 (Fisher's exact test), Q value = 0.58

Table S1024. Gene #342: 'DNAH8 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DNAH8 MUTATED | 3 | 4 | 1 | 0 | 4
DNAH8 WILD-TYPE | 25 | 16 | 10 | 20 | 17

'DNAH8 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00197 (Fisher's exact test), Q value = 0.25

Table S1025. Gene #342: 'DNAH8 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DNAH8 MUTATED | 10 | 0 | 1 | 1
DNAH8 WILD-TYPE | 25 | 33 | 15 | 11

Figure S123. Get High-res Image Gene #342: 'DNAH8 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'DNAH8 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.046 (Fisher's exact test), Q value = 0.42

Table S1026. Gene #342: 'DNAH8 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DNAH8 MUTATED | 9 | 0 | 1 | 1 | 1 | 0 | 0
DNAH8 WILD-TYPE | 25 | 11 | 8 | 6 | 5 | 20 | 9

Figure S124. Get High-res Image Gene #342: 'DNAH8 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'SYCP2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.754 (Fisher's exact test), Q value = 0.9

Table S1027. Gene #343: 'SYCP2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SYCP2 MUTATED | 4 | 3 | 2 | 2 | 1
SYCP2 WILD-TYPE | 24 | 17 | 9 | 18 | 20

'SYCP2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0101 (Fisher's exact test), Q value = 0.39

Table S1028. Gene #343: 'SYCP2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SYCP2 MUTATED | 7 | 0 | 4 | 1
SYCP2 WILD-TYPE | 28 | 33 | 12 | 11

Figure S125. Get High-res Image Gene #343: 'SYCP2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'SYCP2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0156 (Fisher's exact test), Q value = 0.39

Table S1029. Gene #343: 'SYCP2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SYCP2 MUTATED | 9 | 0 | 0 | 2 | 1 | 0 | 0
SYCP2 WILD-TYPE | 25 | 11 | 9 | 5 | 5 | 20 | 9

Figure S126. Get High-res Image Gene #343: 'SYCP2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'ATG5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.287 (Fisher's exact test), Q value = 0.64

Table S1030. Gene #344: 'ATG5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ATG5 MUTATED | 0 | 1 | 0 | 0 | 2
ATG5 WILD-TYPE | 28 | 19 | 11 | 20 | 19

'ATG5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.603 (Fisher's exact test), Q value = 0.81

Table S1031. Gene #344: 'ATG5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ATG5 MUTATED | 1 | 1 | 0 | 1
ATG5 WILD-TYPE | 34 | 32 | 16 | 11

'ATG5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.654 (Fisher's exact test), Q value = 0.84

Table S1032. Gene #344: 'ATG5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ATG5 MUTATED | 2 | 0 | 0 | 0 | 0 | 0 | 1
ATG5 WILD-TYPE | 32 | 11 | 9 | 7 | 6 | 20 | 8

'RTN2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.56 (Fisher's exact test), Q value = 0.78

Table S1033. Gene #345: 'RTN2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RTN2 MUTATED | 1 | 3 | 0 | 1 | 1
RTN2 WILD-TYPE | 27 | 17 | 11 | 19 | 20

'RTN2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0563 (Fisher's exact test), Q value = 0.43

Table S1034. Gene #345: 'RTN2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RTN2 MUTATED | 2 | 0 | 3 | 1
RTN2 WILD-TYPE | 33 | 33 | 13 | 11

'RTN2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.373 (Fisher's exact test), Q value = 0.68

Table S1035. Gene #345: 'RTN2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RTN2 MUTATED | 4 | 0 | 1 | 0 | 1 | 0 | 0
RTN2 WILD-TYPE | 30 | 11 | 8 | 7 | 5 | 20 | 9

'AP2A2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0143 (Fisher's exact test), Q value = 0.39

Table S1036. Gene #346: 'AP2A2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
AP2A2 MUTATED | 0 | 1 | 2 | 0 | 0
AP2A2 WILD-TYPE | 28 | 19 | 9 | 20 | 21

Figure S127. Get High-res Image Gene #346: 'AP2A2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

'AP2A2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0235 (Fisher's exact test), Q value = 0.4

Table S1037. Gene #346: 'AP2A2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
AP2A2 MUTATED | 0 | 0 | 2 | 1
AP2A2 WILD-TYPE | 35 | 33 | 14 | 11

Figure S128. Get High-res Image Gene #346: 'AP2A2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'AP2A2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.211 (Fisher's exact test), Q value = 0.58

Table S1038. Gene #346: 'AP2A2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
AP2A2 MUTATED | 1 | 0 | 0 | 1 | 1 | 0 | 0
AP2A2 WILD-TYPE | 33 | 11 | 9 | 6 | 5 | 20 | 9

'ECT2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1039. Gene #347: 'ECT2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ECT2 MUTATED | 1 | 1 | 0 | 0 | 1
ECT2 WILD-TYPE | 27 | 19 | 11 | 20 | 20

'ECT2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.383 (Fisher's exact test), Q value = 0.68

Table S1040. Gene #347: 'ECT2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ECT2 MUTATED | 2 | 0 | 0 | 1
ECT2 WILD-TYPE | 33 | 33 | 16 | 11

'ECT2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.654 (Fisher's exact test), Q value = 0.84

Table S1041. Gene #347: 'ECT2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ECT2 MUTATED | 2 | 0 | 1 | 0 | 0 | 0 | 0
ECT2 WILD-TYPE | 32 | 11 | 8 | 7 | 6 | 20 | 9

'ZNF174 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.786 (Fisher's exact test), Q value = 0.92

Table S1042. Gene #348: 'ZNF174 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZNF174 MUTATED | 0 | 1 | 0 | 1 | 1
ZNF174 WILD-TYPE | 28 | 19 | 11 | 19 | 20

'ZNF174 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.861 (Fisher's exact test), Q value = 0.94

Table S1043. Gene #348: 'ZNF174 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZNF174 MUTATED | 1 | 1 | 1 | 0
ZNF174 WILD-TYPE | 34 | 32 | 15 | 12

'ZNF174 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.581 (Fisher's exact test), Q value = 0.79

Table S1044. Gene #348: 'ZNF174 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZNF174 MUTATED | 1 | 0 | 0 | 1 | 0 | 1 | 0
ZNF174 WILD-TYPE | 33 | 11 | 9 | 6 | 6 | 19 | 9

'JAM3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.67 (Fisher's exact test), Q value = 0.85

Table S1045. Gene #349: 'JAM3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
JAM3 MUTATED | 3 | 1 | 1 | 0 | 1
JAM3 WILD-TYPE | 25 | 19 | 10 | 20 | 20

'JAM3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.167 (Fisher's exact test), Q value = 0.56

Table S1046. Gene #349: 'JAM3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
JAM3 MUTATED | 3 | 0 | 2 | 1
JAM3 WILD-TYPE | 32 | 33 | 14 | 11

'JAM3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.275 (Fisher's exact test), Q value = 0.63

Table S1047. Gene #349: 'JAM3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
JAM3 MUTATED | 4 | 0 | 0 | 1 | 1 | 0 | 0
JAM3 WILD-TYPE | 30 | 11 | 9 | 6 | 5 | 20 | 9

'EEA1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.663 (Fisher's exact test), Q value = 0.85

Table S1048. Gene #350: 'EEA1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
EEA1 MUTATED | 3 | 2 | 2 | 1 | 1
EEA1 WILD-TYPE | 25 | 18 | 9 | 19 | 20

'EEA1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.474 (Fisher's exact test), Q value = 0.75

Table S1049. Gene #350: 'EEA1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
EEA1 MUTATED | 5 | 2 | 2 | 0
EEA1 WILD-TYPE | 30 | 31 | 14 | 12

'EEA1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.422 (Fisher's exact test), Q value = 0.7

Table S1050. Gene #350: 'EEA1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
EEA1 MUTATED | 5 | 1 | 0 | 2 | 0 | 1 | 0
EEA1 WILD-TYPE | 29 | 10 | 9 | 5 | 6 | 19 | 9

'RTN3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.216 (Fisher's exact test), Q value = 0.58

Table S1051. Gene #351: 'RTN3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RTN3 MUTATED | 1 | 4 | 0 | 1 | 3
RTN3 WILD-TYPE | 27 | 16 | 11 | 19 | 18

'RTN3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0132 (Fisher's exact test), Q value = 0.39

Table S1052. Gene #351: 'RTN3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RTN3 MUTATED | 7 | 0 | 2 | 0
RTN3 WILD-TYPE | 28 | 33 | 14 | 12

Figure S129. Get High-res Image Gene #351: 'RTN3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'RTN3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.134 (Fisher's exact test), Q value = 0.51

Table S1053. Gene #351: 'RTN3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RTN3 MUTATED | 7 | 0 | 1 | 1 | 0 | 0 | 0
RTN3 WILD-TYPE | 27 | 11 | 8 | 6 | 6 | 20 | 9

'ZBTB7B MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.16 (Fisher's exact test), Q value = 0.56

Table S1054. Gene #352: 'ZBTB7B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZBTB7B MUTATED | 1 | 0 | 0 | 0 | 3
ZBTB7B WILD-TYPE | 27 | 20 | 11 | 20 | 18

'ZBTB7B MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.38 (Fisher's exact test), Q value = 0.68

Table S1055. Gene #352: 'ZBTB7B MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZBTB7B MUTATED | 2 | 0 | 0 | 1
ZBTB7B WILD-TYPE | 33 | 33 | 16 | 11

'ZBTB7B MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.493 (Fisher's exact test), Q value = 0.75

Table S1056. Gene #352: 'ZBTB7B MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZBTB7B MUTATED | 2 | 0 | 0 | 0 | 1 | 0 | 0
ZBTB7B WILD-TYPE | 32 | 11 | 9 | 7 | 5 | 20 | 9

'ZC3H18 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.57 (Fisher's exact test), Q value = 0.78

Table S1057. Gene #353: 'ZC3H18 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZC3H18 MUTATED | 1 | 3 | 0 | 1 | 2
ZC3H18 WILD-TYPE | 27 | 17 | 11 | 19 | 19

'ZC3H18 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.805 (Fisher's exact test), Q value = 0.93

Table S1058. Gene #353: 'ZC3H18 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZC3H18 MUTATED | 4 | 2 | 1 | 0
ZC3H18 WILD-TYPE | 31 | 31 | 15 | 12

'ZC3H18 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.213 (Fisher's exact test), Q value = 0.58

Table S1059. Gene #353: 'ZC3H18 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZC3H18 MUTATED | 4 | 0 | 0 | 1 | 0 | 0 | 2
ZC3H18 WILD-TYPE | 30 | 11 | 9 | 6 | 6 | 20 | 7

'FAHD2B MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1060. Gene #354: 'FAHD2B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FAHD2B MUTATED | 1 | 1 | 0 | 0 | 1
FAHD2B WILD-TYPE | 27 | 19 | 11 | 20 | 20

'SETD7 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.548 (Fisher's exact test), Q value = 0.77

Table S1061. Gene #355: 'SETD7 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SETD7 MUTATED | 1 | 0 | 1 | 1 | 0
SETD7 WILD-TYPE | 27 | 20 | 10 | 19 | 21

'SETD7 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.504 (Fisher's exact test), Q value = 0.75

Table S1062. Gene #355: 'SETD7 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SETD7 MUTATED | 2 | 0 | 1 | 0
SETD7 WILD-TYPE | 33 | 33 | 15 | 12

'SETD7 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.695 (Fisher's exact test), Q value = 0.86

Table S1063. Gene #355: 'SETD7 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SETD7 MUTATED | 3 | 0 | 0 | 0 | 0 | 0 | 0
SETD7 WILD-TYPE | 31 | 11 | 9 | 7 | 6 | 20 | 9

'ZNF510 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.224 (Fisher's exact test), Q value = 0.59

Table S1064. Gene #356: 'ZNF510 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZNF510 MUTATED | 0 | 2 | 1 | 0 | 1
ZNF510 WILD-TYPE | 28 | 18 | 10 | 20 | 20

'ZNF510 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.318 (Fisher's exact test), Q value = 0.65

Table S1065. Gene #356: 'ZNF510 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZNF510 MUTATED | 3 | 0 | 1 | 0
ZNF510 WILD-TYPE | 32 | 33 | 15 | 12

'ZNF510 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.482 (Fisher's exact test), Q value = 0.75

Table S1066. Gene #356: 'ZNF510 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZNF510 MUTATED | 3 | 0 | 0 | 1 | 0 | 0 | 0
ZNF510 WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 20 | 9

'KIAA0408 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.663 (Fisher's exact test), Q value = 0.85

Table S1067. Gene #357: 'KIAA0408 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KIAA0408 MUTATED | 3 | 3 | 0 | 1 | 1
KIAA0408 WILD-TYPE | 25 | 17 | 11 | 19 | 20

'KIAA0408 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.407 (Fisher's exact test), Q value = 0.69

Table S1068. Gene #357: 'KIAA0408 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KIAA0408 MUTATED | 3 | 2 | 0 | 2
KIAA0408 WILD-TYPE | 32 | 31 | 16 | 10

'KIAA0408 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.374 (Fisher's exact test), Q value = 0.68

Table S1069. Gene #357: 'KIAA0408 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KIAA0408 MUTATED | 2 | 0 | 2 | 0 | 1 | 1 | 1
KIAA0408 WILD-TYPE | 32 | 11 | 7 | 7 | 5 | 19 | 8

'PRR5L MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.286 (Fisher's exact test), Q value = 0.64

Table S1070. Gene #358: 'PRR5L MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PRR5L MUTATED | 0 | 0 | 0 | 1 | 2
PRR5L WILD-TYPE | 28 | 20 | 11 | 19 | 19

'PRR5L MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1071. Gene #358: 'PRR5L MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PRR5L MUTATED | 2 | 1 | 0 | 0
PRR5L WILD-TYPE | 33 | 32 | 16 | 12

'PRR5L MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1072. Gene #358: 'PRR5L MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PRR5L MUTATED | 2 | 0 | 0 | 0 | 0 | 1 | 0
PRR5L WILD-TYPE | 32 | 11 | 9 | 7 | 6 | 19 | 9

'DST MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.948 (Fisher's exact test), Q value = 1

Table S1073. Gene #359: 'DST MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
DST MUTATED | 5 | 3 | 1 | 3 | 2
DST WILD-TYPE | 23 | 17 | 10 | 17 | 19

'DST MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.045 (Fisher's exact test), Q value = 0.42

Table S1074. Gene #359: 'DST MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
DST MUTATED | 9 | 1 | 2 | 1
DST WILD-TYPE | 26 | 32 | 14 | 11

Figure S130. Get High-res Image Gene #359: 'DST MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'DST MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0503 (Fisher's exact test), Q value = 0.43

Table S1075. Gene #359: 'DST MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
DST MUTATED | 10 | 0 | 0 | 1 | 1 | 1 | 0
DST WILD-TYPE | 24 | 11 | 9 | 6 | 5 | 19 | 9

'NPY MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.372 (Fisher's exact test), Q value = 0.68

Table S1076. Gene #360: 'NPY MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NPY MUTATED | 0 | 1 | 1 | 0 | 1
NPY WILD-TYPE | 28 | 19 | 10 | 20 | 20

'NPY MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.863 (Fisher's exact test), Q value = 0.94

Table S1077. Gene #360: 'NPY MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NPY MUTATED | 1 | 2 | 0 | 0
NPY WILD-TYPE | 34 | 31 | 16 | 12

'NPY MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.922 (Fisher's exact test), Q value = 0.98

Table S1078. Gene #360: 'NPY MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NPY MUTATED | 1 | 1 | 0 | 0 | 0 | 1 | 0
NPY WILD-TYPE | 33 | 10 | 9 | 7 | 6 | 19 | 9

'VASP MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.939 (Fisher's exact test), Q value = 0.99

Table S1079. Gene #361: 'VASP MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
VASP MUTATED | 2 | 1 | 0 | 0 | 1
VASP WILD-TYPE | 26 | 19 | 11 | 20 | 20

'VASP MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1080. Gene #361: 'VASP MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
VASP MUTATED | 2 | 1 | 0 | 0
VASP WILD-TYPE | 33 | 32 | 16 | 12

'VASP MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.656 (Fisher's exact test), Q value = 0.84

Table S1081. Gene #361: 'VASP MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
VASP MUTATED | 2 | 0 | 0 | 0 | 0 | 0 | 1
VASP WILD-TYPE | 32 | 11 | 9 | 7 | 6 | 20 | 8

'COL5A3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0658 (Fisher's exact test), Q value = 0.45

Table S1082. Gene #362: 'COL5A3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
COL5A3 MUTATED | 0 | 3 | 0 | 0 | 2
COL5A3 WILD-TYPE | 28 | 17 | 11 | 20 | 19

'COL5A3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.173 (Fisher's exact test), Q value = 0.56

Table S1083. Gene #362: 'COL5A3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
COL5A3 MUTATED | 4 | 0 | 1 | 0
COL5A3 WILD-TYPE | 31 | 33 | 15 | 12

'COL5A3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.458 (Fisher's exact test), Q value = 0.73

Table S1084. Gene #362: 'COL5A3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
COL5A3 MUTATED | 3 | 0 | 1 | 1 | 0 | 0 | 0
COL5A3 WILD-TYPE | 31 | 11 | 8 | 6 | 6 | 20 | 9

'KCNQ3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.909 (Fisher's exact test), Q value = 0.98

Table S1085. Gene #363: 'KCNQ3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
KCNQ3 MUTATED | 3 | 3 | 1 | 1 | 2
KCNQ3 WILD-TYPE | 25 | 17 | 10 | 19 | 19

'KCNQ3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0723 (Fisher's exact test), Q value = 0.47

Table S1086. Gene #363: 'KCNQ3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
KCNQ3 MUTATED | 7 | 1 | 2 | 0
KCNQ3 WILD-TYPE | 28 | 32 | 14 | 12

'KCNQ3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.376 (Fisher's exact test), Q value = 0.68

Table S1087. Gene #363: 'KCNQ3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
KCNQ3 MUTATED | 7 | 0 | 0 | 1 | 0 | 1 | 1
KCNQ3 WILD-TYPE | 27 | 11 | 9 | 6 | 6 | 19 | 8

'PLXNA1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.281 (Fisher's exact test), Q value = 0.64

Table S1088. Gene #364: 'PLXNA1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PLXNA1 MUTATED | 1 | 3 | 0 | 3 | 4
PLXNA1 WILD-TYPE | 27 | 17 | 11 | 17 | 17

'PLXNA1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0629 (Fisher's exact test), Q value = 0.45

Table S1089. Gene #364: 'PLXNA1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PLXNA1 MUTATED | 8 | 1 | 1 | 1
PLXNA1 WILD-TYPE | 27 | 32 | 15 | 11

'PLXNA1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0949 (Fisher's exact test), Q value = 0.47

Table S1090. Gene #364: 'PLXNA1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PLXNA1 MUTATED | 7 | 0 | 0 | 1 | 1 | 0 | 2
PLXNA1 WILD-TYPE | 27 | 11 | 9 | 6 | 5 | 20 | 7

'ZNF395 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.855 (Fisher's exact test), Q value = 0.94

Table S1091. Gene #365: 'ZNF395 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZNF395 MUTATED | 1 | 1 | 0 | 1 | 0
ZNF395 WILD-TYPE | 27 | 19 | 11 | 19 | 21

'ZNF395 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.332 (Fisher's exact test), Q value = 0.67

Table S1092. Gene #365: 'ZNF395 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZNF395 MUTATED | 1 | 0 | 1 | 1
ZNF395 WILD-TYPE | 34 | 33 | 15 | 11

'ZNF395 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.209 (Fisher's exact test), Q value = 0.58

Table S1093. Gene #365: 'ZNF395 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZNF395 MUTATED | 1 | 0 | 0 | 1 | 1 | 0 | 0
ZNF395 WILD-TYPE | 33 | 11 | 9 | 6 | 5 | 20 | 9

'PLA2G4C MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0965 (Fisher's exact test), Q value = 0.48

Table S1094. Gene #366: 'PLA2G4C MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PLA2G4C MUTATED | 1 | 4 | 0 | 0 | 1
PLA2G4C WILD-TYPE | 27 | 16 | 11 | 20 | 20

'PLA2G4C MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0911 (Fisher's exact test), Q value = 0.47

Table S1095. Gene #366: 'PLA2G4C MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PLA2G4C MUTATED | 5 | 0 | 1 | 0
PLA2G4C WILD-TYPE | 30 | 33 | 15 | 12

'PLA2G4C MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.414 (Fisher's exact test), Q value = 0.69

Table S1096. Gene #366: 'PLA2G4C MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PLA2G4C MUTATED | 4 | 0 | 0 | 1 | 0 | 0 | 1
PLA2G4C WILD-TYPE | 30 | 11 | 9 | 6 | 6 | 20 | 8

'RBM6 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.696 (Fisher's exact test), Q value = 0.86

Table S1097. Gene #367: 'RBM6 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
RBM6 MUTATED | 3 | 3 | 0 | 1 | 3
RBM6 WILD-TYPE | 25 | 17 | 11 | 19 | 18

'RBM6 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.231 (Fisher's exact test), Q value = 0.6

Table S1098. Gene #367: 'RBM6 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
RBM6 MUTATED | 6 | 1 | 1 | 1
RBM6 WILD-TYPE | 29 | 32 | 15 | 11

'RBM6 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.169 (Fisher's exact test), Q value = 0.56

Table S1099. Gene #367: 'RBM6 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
RBM6 MUTATED | 5 | 0 | 0 | 1 | 1 | 0 | 2
RBM6 WILD-TYPE | 29 | 11 | 9 | 6 | 5 | 20 | 7

'COL18A1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.222 (Fisher's exact test), Q value = 0.58

Table S1100. Gene #368: 'COL18A1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
COL18A1 MUTATED | 6 | 0 | 1 | 2 | 2
COL18A1 WILD-TYPE | 22 | 20 | 10 | 18 | 19

'COL18A1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.673 (Fisher's exact test), Q value = 0.85

Table S1101. Gene #368: 'COL18A1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
COL18A1 MUTATED | 5 | 3 | 2 | 0
COL18A1 WILD-TYPE | 30 | 30 | 14 | 12

'COL18A1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.368 (Fisher's exact test), Q value = 0.68

Table S1102. Gene #368: 'COL18A1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
COL18A1 MUTATED | 5 | 0 | 0 | 2 | 0 | 3 | 0
COL18A1 WILD-TYPE | 29 | 11 | 9 | 5 | 6 | 17 | 9

'ERBB3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.187 (Fisher's exact test), Q value = 0.56

Table S1103. Gene #369: 'ERBB3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ERBB3 MUTATED | 1 | 0 | 0 | 3 | 3
ERBB3 WILD-TYPE | 27 | 20 | 11 | 17 | 18

'ERBB3 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.198 (Fisher's exact test), Q value = 0.57

Table S1104. Gene #369: 'ERBB3 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ERBB3 MUTATED | 5 | 1 | 0 | 1
ERBB3 WILD-TYPE | 30 | 32 | 16 | 11

'ERBB3 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.467 (Fisher's exact test), Q value = 0.74

Table S1105. Gene #369: 'ERBB3 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ERBB3 MUTATED | 6 | 0 | 0 | 0 | 0 | 1 | 0
ERBB3 WILD-TYPE | 28 | 11 | 9 | 7 | 6 | 19 | 9

'PRDM2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.154 (Fisher's exact test), Q value = 0.55

Table S1106. Gene #370: 'PRDM2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PRDM2 MUTATED | 5 | 3 | 3 | 0 | 2
PRDM2 WILD-TYPE | 23 | 17 | 8 | 20 | 19

'PRDM2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.502 (Fisher's exact test), Q value = 0.75

Table S1107. Gene #370: 'PRDM2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PRDM2 MUTATED | 6 | 2 | 2 | 2
PRDM2 WILD-TYPE | 29 | 31 | 14 | 10

'PRDM2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.204 (Fisher's exact test), Q value = 0.57

Table S1108. Gene #370: 'PRDM2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PRDM2 MUTATED | 7 | 0 | 0 | 1 | 2 | 1 | 1
PRDM2 WILD-TYPE | 27 | 11 | 9 | 6 | 4 | 19 | 8

'C7ORF50 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1109. Gene #371: 'C7ORF50 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
C7ORF50 MUTATED | 1 | 1 | 0 | 0 | 1
C7ORF50 WILD-TYPE | 27 | 19 | 11 | 20 | 20

'C7ORF50 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.282 (Fisher's exact test), Q value = 0.64

Table S1110. Gene #371: 'C7ORF50 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
C7ORF50 MUTATED | 3 | 0 | 0 | 0
C7ORF50 WILD-TYPE | 32 | 33 | 16 | 12

'C7ORF50 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.651 (Fisher's exact test), Q value = 0.84

Table S1111. Gene #371: 'C7ORF50 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
C7ORF50 MUTATED | 2 | 0 | 0 | 0 | 0 | 0 | 1
C7ORF50 WILD-TYPE | 32 | 11 | 9 | 7 | 6 | 20 | 8

'ARFGAP2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1112. Gene #372: 'ARFGAP2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ARFGAP2 MUTATED | 1 | 1 | 0 | 0 | 1
ARFGAP2 WILD-TYPE | 27 | 19 | 11 | 20 | 20

'ARFGAP2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1113. Gene #372: 'ARFGAP2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ARFGAP2 MUTATED | 2 | 1 | 0 | 0
ARFGAP2 WILD-TYPE | 33 | 32 | 16 | 12

'ARFGAP2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.651 (Fisher's exact test), Q value = 0.84

Table S1114. Gene #372: 'ARFGAP2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ARFGAP2 MUTATED | 2 | 0 | 0 | 0 | 0 | 0 | 1
ARFGAP2 WILD-TYPE | 32 | 11 | 9 | 7 | 6 | 20 | 8

'FAM81B MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.85 (Fisher's exact test), Q value = 0.94

Table S1115. Gene #373: 'FAM81B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
FAM81B MUTATED | 1 | 2 | 1 | 1 | 1
FAM81B WILD-TYPE | 27 | 18 | 10 | 19 | 20

'FAM81B MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0909 (Fisher's exact test), Q value = 0.47

Table S1116. Gene #373: 'FAM81B MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
FAM81B MUTATED | 5 | 0 | 1 | 0
FAM81B WILD-TYPE | 30 | 33 | 15 | 12

'FAM81B MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.411 (Fisher's exact test), Q value = 0.69

Table S1117. Gene #373: 'FAM81B MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
FAM81B MUTATED | 4 | 0 | 1 | 1 | 0 | 0 | 0
FAM81B WILD-TYPE | 30 | 11 | 8 | 6 | 6 | 20 | 9

'LIN37 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.784 (Fisher's exact test), Q value = 0.92

Table S1118. Gene #374: 'LIN37 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
LIN37 MUTATED | 0 | 1 | 0 | 1 | 1
LIN37 WILD-TYPE | 28 | 19 | 11 | 19 | 20

'LIN37 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.333 (Fisher's exact test), Q value = 0.67

Table S1119. Gene #374: 'LIN37 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
LIN37 MUTATED | 1 | 0 | 1 | 1
LIN37 WILD-TYPE | 34 | 33 | 15 | 11

'LIN37 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.212 (Fisher's exact test), Q value = 0.58

Table S1120. Gene #374: 'LIN37 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
LIN37 MUTATED | 1 | 0 | 0 | 1 | 1 | 0 | 0
LIN37 WILD-TYPE | 33 | 11 | 9 | 6 | 5 | 20 | 9

'SPRYD5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.109 (Fisher's exact test), Q value = 0.48

Table S1121. Gene #375: 'SPRYD5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SPRYD5 MUTATED | 1 | 4 | 0 | 0 | 2
SPRYD5 WILD-TYPE | 27 | 16 | 11 | 20 | 19

'SPRYD5 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.35 (Fisher's exact test), Q value = 0.68

Table S1122. Gene #375: 'SPRYD5 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SPRYD5 MUTATED | 4 | 1 | 2 | 0
SPRYD5 WILD-TYPE | 31 | 32 | 14 | 12

'SPRYD5 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.319 (Fisher's exact test), Q value = 0.65

Table S1123. Gene #375: 'SPRYD5 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SPRYD5 MUTATED | 5 | 0 | 0 | 1 | 0 | 0 | 1
SPRYD5 WILD-TYPE | 29 | 11 | 9 | 6 | 6 | 20 | 8

'INHBA MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.286 (Fisher's exact test), Q value = 0.64

Table S1124. Gene #376: 'INHBA MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
INHBA MUTATED | 0 | 0 | 0 | 1 | 2
INHBA WILD-TYPE | 28 | 20 | 11 | 19 | 19

'INHBA MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.508 (Fisher's exact test), Q value = 0.75

Table S1125. Gene #376: 'INHBA MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
INHBA MUTATED | 2 | 0 | 1 | 0
INHBA WILD-TYPE | 33 | 33 | 15 | 12

'INHBA MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.366 (Fisher's exact test), Q value = 0.68

Table S1126. Gene #376: 'INHBA MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
INHBA MUTATED | 1 | 0 | 1 | 1 | 0 | 0 | 0
INHBA WILD-TYPE | 33 | 11 | 8 | 6 | 6 | 20 | 9

'SOX8 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1127. Gene #377: 'SOX8 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SOX8 MUTATED | 2 | 1 | 0 | 1 | 1
SOX8 WILD-TYPE | 26 | 19 | 11 | 19 | 20

'SOX8 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.266 (Fisher's exact test), Q value = 0.63

Table S1128. Gene #377: 'SOX8 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SOX8 MUTATED | 3 | 0 | 1 | 1
SOX8 WILD-TYPE | 32 | 33 | 15 | 11

'SOX8 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.356 (Fisher's exact test), Q value = 0.68

Table S1129. Gene #377: 'SOX8 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SOX8 MUTATED | 4 | 0 | 0 | 0 | 1 | 0 | 0
SOX8 WILD-TYPE | 30 | 11 | 9 | 7 | 5 | 20 | 9

'WDR60 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.424 (Fisher's exact test), Q value = 0.71

Table S1130. Gene #378: 'WDR60 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
WDR60 MUTATED | 3 | 2 | 2 | 0 | 2
WDR60 WILD-TYPE | 25 | 18 | 9 | 20 | 19

'WDR60 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.00956 (Fisher's exact test), Q value = 0.39

Table S1131. Gene #378: 'WDR60 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
WDR60 MUTATED | 5 | 0 | 4 | 0
WDR60 WILD-TYPE | 30 | 33 | 12 | 12

Figure S131. Get High-res Image Gene #378: 'WDR60 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'WDR60 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.0199 (Fisher's exact test), Q value = 0.4

Table S1132. Gene #378: 'WDR60 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
WDR60 MUTATED | 6 | 0 | 0 | 3 | 0 | 0 | 0
WDR60 WILD-TYPE | 28 | 11 | 9 | 4 | 6 | 20 | 9

Figure S132. Get High-res Image Gene #378: 'WDR60 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'TCP10L MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.484 (Fisher's exact test), Q value = 0.75

Table S1133. Gene #379: 'TCP10L MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
TCP10L MUTATED | 2 | 1 | 1 | 0 | 0
TCP10L WILD-TYPE | 26 | 19 | 10 | 20 | 21

'TCP10L MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.185 (Fisher's exact test), Q value = 0.56

Table S1134. Gene #379: 'TCP10L MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
TCP10L MUTATED | 2 | 0 | 2 | 0
TCP10L WILD-TYPE | 33 | 33 | 14 | 12

'TCP10L MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.479 (Fisher's exact test), Q value = 0.75

Table S1135. Gene #379: 'TCP10L MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
TCP10L MUTATED | 3 | 0 | 0 | 1 | 0 | 0 | 0
TCP10L WILD-TYPE | 31 | 11 | 9 | 6 | 6 | 20 | 9

'MGAT4C MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.892 (Fisher's exact test), Q value = 0.97

Table S1136. Gene #380: 'MGAT4C MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MGAT4C MUTATED | 1 | 1 | 0 | 2 | 1
MGAT4C WILD-TYPE | 27 | 19 | 11 | 18 | 20

'MGAT4C MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.189 (Fisher's exact test), Q value = 0.56

Table S1137. Gene #380: 'MGAT4C MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MGAT4C MUTATED | 2 | 0 | 2 | 1
MGAT4C WILD-TYPE | 33 | 33 | 14 | 11

'MGAT4C MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.181 (Fisher's exact test), Q value = 0.56

Table S1138. Gene #380: 'MGAT4C MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MGAT4C MUTATED | 3 | 0 | 0 | 2 | 0 | 0 | 0
MGAT4C WILD-TYPE | 31 | 11 | 9 | 5 | 6 | 20 | 9

'ATP6V1C1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.724 (Fisher's exact test), Q value = 0.88

Table S1139. Gene #381: 'ATP6V1C1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ATP6V1C1 MUTATED | 1 | 1 | 0 | 0 | 2
ATP6V1C1 WILD-TYPE | 27 | 19 | 11 | 20 | 19

'ATP6V1C1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.516 (Fisher's exact test), Q value = 0.76

Table S1140. Gene #381: 'ATP6V1C1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ATP6V1C1 MUTATED | 3 | 1 | 0 | 0
ATP6V1C1 WILD-TYPE | 32 | 32 | 16 | 12

'ATP6V1C1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.674 (Fisher's exact test), Q value = 0.85

Table S1141. Gene #381: 'ATP6V1C1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ATP6V1C1 MUTATED | 2 | 1 | 1 | 0 | 0 | 0 | 0
ATP6V1C1 WILD-TYPE | 32 | 10 | 8 | 7 | 6 | 20 | 9

'MNT MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.196 (Fisher's exact test), Q value = 0.57

Table S1142. Gene #382: 'MNT MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
MNT MUTATED | 0 | 2 | 0 | 1 | 3
MNT WILD-TYPE | 28 | 18 | 11 | 19 | 18

'MNT MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.346 (Fisher's exact test), Q value = 0.68

Table S1143. Gene #382: 'MNT MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
MNT MUTATED | 4 | 1 | 0 | 1
MNT WILD-TYPE | 31 | 32 | 16 | 11

'MNT MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.467 (Fisher's exact test), Q value = 0.74

Table S1144. Gene #382: 'MNT MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
MNT MUTATED | 3 | 1 | 0 | 0 | 1 | 0 | 1
MNT WILD-TYPE | 31 | 10 | 9 | 7 | 5 | 20 | 8

'PLXNB1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.947 (Fisher's exact test), Q value = 1

Table S1145. Gene #383: 'PLXNB1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
PLXNB1 MUTATED | 3 | 1 | 1 | 1 | 2
PLXNB1 WILD-TYPE | 25 | 19 | 10 | 19 | 19

'PLXNB1 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0157 (Fisher's exact test), Q value = 0.39

Table S1146. Gene #383: 'PLXNB1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
PLXNB1 MUTATED | 7 | 0 | 1 | 0
PLXNB1 WILD-TYPE | 28 | 33 | 15 | 12

Figure S133. Get High-res Image Gene #383: 'PLXNB1 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'PLXNB1 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.101 (Fisher's exact test), Q value = 0.48

Table S1147. Gene #383: 'PLXNB1 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
PLXNB1 MUTATED | 7 | 0 | 0 | 1 | 0 | 0 | 0
PLXNB1 WILD-TYPE | 27 | 11 | 9 | 6 | 6 | 20 | 9

'STIM2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.482 (Fisher's exact test), Q value = 0.75

Table S1148. Gene #384: 'STIM2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
STIM2 MUTATED | 1 | 2 | 1 | 0 | 2
STIM2 WILD-TYPE | 27 | 18 | 10 | 20 | 19

'STIM2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.266 (Fisher's exact test), Q value = 0.63

Table S1149. Gene #384: 'STIM2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
STIM2 MUTATED | 3 | 0 | 1 | 1
STIM2 WILD-TYPE | 32 | 33 | 15 | 11

'STIM2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.456 (Fisher's exact test), Q value = 0.73

Table S1150. Gene #384: 'STIM2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
STIM2 MUTATED | 3 | 0 | 1 | 1 | 0 | 0 | 0
STIM2 WILD-TYPE | 31 | 11 | 8 | 6 | 6 | 20 | 9

'CYB5R4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.819 (Fisher's exact test), Q value = 0.93

Table S1151. Gene #385: 'CYB5R4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
CYB5R4 MUTATED | 1 | 1 | 1 | 0 | 1
CYB5R4 WILD-TYPE | 27 | 19 | 10 | 20 | 20

'CYB5R4 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1152. Gene #385: 'CYB5R4 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
CYB5R4 MUTATED | 2 | 1 | 1 | 0
CYB5R4 WILD-TYPE | 33 | 32 | 15 | 12

'CYB5R4 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.392 (Fisher's exact test), Q value = 0.69

Table S1153. Gene #385: 'CYB5R4 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
CYB5R4 MUTATED | 2 | 0 | 0 | 1 | 0 | 0 | 1
CYB5R4 WILD-TYPE | 32 | 11 | 9 | 6 | 6 | 20 | 8

'SIAH2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.161 (Fisher's exact test), Q value = 0.56

Table S1154. Gene #386: 'SIAH2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
SIAH2 MUTATED | 0 | 1 | 0 | 2 | 0
SIAH2 WILD-TYPE | 28 | 19 | 11 | 18 | 21

'SIAH2 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.865 (Fisher's exact test), Q value = 0.94

Table S1155. Gene #386: 'SIAH2 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
SIAH2 MUTATED | 1 | 2 | 0 | 0
SIAH2 WILD-TYPE | 34 | 31 | 16 | 12

'SIAH2 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.26 (Fisher's exact test), Q value = 0.63

Table S1156. Gene #386: 'SIAH2 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
SIAH2 MUTATED | 0 | 0 | 0 | 0 | 0 | 2 | 1
SIAH2 WILD-TYPE | 34 | 11 | 9 | 7 | 6 | 18 | 8

'NUP210L MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.858 (Fisher's exact test), Q value = 0.94

Table S1157. Gene #387: 'NUP210L MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
NUP210L MUTATED | 2 | 2 | 2 | 2 | 3
NUP210L WILD-TYPE | 26 | 18 | 9 | 18 | 18

'NUP210L MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.0415 (Fisher's exact test), Q value = 0.42

Table S1158. Gene #387: 'NUP210L MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
NUP210L MUTATED | 6 | 0 | 2 | 2
NUP210L WILD-TYPE | 29 | 33 | 14 | 10

Figure S134. Get High-res Image Gene #387: 'NUP210L MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

'NUP210L MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.039 (Fisher's exact test), Q value = 0.42

Table S1159. Gene #387: 'NUP210L MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
NUP210L MUTATED | 7 | 0 | 0 | 1 | 2 | 0 | 0
NUP210L WILD-TYPE | 27 | 11 | 9 | 6 | 4 | 20 | 9

Figure S135. Get High-res Image Gene #387: 'NUP210L MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

'ZNF609 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.684 (Fisher's exact test), Q value = 0.86

Table S1160. Gene #388: 'ZNF609 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 28 | 20 | 11 | 20 | 21
ZNF609 MUTATED | 2 | 2 | 0 | 1 | 0
ZNF609 WILD-TYPE | 26 | 18 | 11 | 19 | 21

'ZNF609 MUTATION STATUS' versus 'METHYLATION_CNMF'

P value = 0.112 (Fisher's exact test), Q value = 0.48

Table S1161. Gene #388: 'ZNF609 MUTATION STATUS' versus Molecular Subtype #2: 'METHYLATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 35 | 33 | 16 | 12
ZNF609 MUTATED | 1 | 1 | 3 | 0
ZNF609 WILD-TYPE | 34 | 32 | 13 | 12

'ZNF609 MUTATION STATUS' versus 'METHYLATION_CHIERARCHICAL'

P value = 0.148 (Fisher's exact test), Q value = 0.54

Table S1162. Gene #388: 'ZNF609 MUTATION STATUS' versus Molecular Subtype #3: 'METHYLATION_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 34 | 11 | 9 | 7 | 6 | 20 | 9
ZNF609 MUTATED | 2 | 0 | 0 | 2 | 0 | 0 | 1
ZNF609 WILD-TYPE | 32 | 11 | 9 | 5 | 6 | 20 | 8

Methods & Data
Input

- Mutation data file = sample_sig_gene_table.txt from Mutsig_2CV pipeline

- Processed Mutation data file = /cromwell_root/fc-8b2df640-93e1-40a2-b735-5b7a14ef6398/dc84de78-e224-489d-a892-238209655610/correlate_genomic_events_all/381a4ae2-a2b0-4c20-81f1-89a7993687e1/call-preprocess_genomic_event/transformed.cor.cli.txt

- Molecular subtypes file = /cromwell_root/fc-8b2df640-93e1-40a2-b735-5b7a14ef6398/10d02b45-07ea-40cc-ac82-013e5f89ebb2/aggregate_clusters_workflow/b0f8dcb2-0993-4424-ad42-552c0bd1a2d5/call-aggregate_clusters/CPTAC3-UCEC-TP.transposedmergedcluster.txt

- Number of patients = 100

- Number of significantly mutated genes = 388

- Number of Molecular subtypes = 3

- Exclude genes that fewer than K tumors have mutations, K = 3

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

References
[1] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[2] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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