Kidney Renal Papillary Cell Carcinoma: PARADIGM pathway analysis of mRNA expression and copy number data
Maintained by TCGA GDAC Team (Broad Institute/Dana-Farber Cancer Institute/Harvard Medical School)
Overview
Introduction

PAthway Representation and Analysis by Direct Inference on Graphical Models (PARADIGM) predicts the activity of a diverse set of molecular concepts such as genes, complexes, and processes. The predicted activities are called Inferred Pathway Levels (IPLs) and are derived from a probabilistic belief propagation strategy that incorporates multimodal data such as copy number and gene expression estimates with a concept's pathway context.

Summary

There were 40 significant pathways identified in this analysis.

Table 1.  Get Full Table Top 10 out of 131 pathways in order of significance.

Pathway.Name Avg.Num.Perturbations
IL12-mediated signaling events 2
Syndecan-1-mediated signaling events 2
HIF-1-alpha transcription factor network 2
Fc-epsilon receptor I signaling in mast cells 2
TRAIL signaling pathway 2
Endothelins 2
IL23-mediated signaling events 2
E-cadherin signaling events 2
Caspase cascade in apoptosis 1
PLK2 and PLK4 events 1
Results

The following list describes the columns found in Table 2.

  • Pathway.Name = Full pathway name of curated PARADIGM pathway

  • Avg.Num.Perturbations = Average number of samples with perturbations across the pathway concepts determined by a background permutation model (>2 standard deviations away from the permuted distribution)

  • Total.Perturbations = Total number of perturbed concepts across all samples (>2 standard deviations away from the permuted distribution)

  • Num.Entities = Number of concepts that belong to the pathway

  • Min.Mean.Truth = Minimum IPL for concepts in the pathway among real samples

  • Max.Mean.Truth = Maximum IPL for concepts in the pathway among real samples

  • Min.Mean.Within = Minimum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Max.Mean.Within = Maximum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Min.Mean.Any = Minimum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes)

  • Max.Mean.Any = Maximum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes).

Table 2.  Get Full Table This summary table provides a report of cancer type specific pathway perturbations. Click on the links in the first column to display more detailed results for each pathway.

Pathway.Name Avg.Num.Perturbations Total.Perturbations Num.Entities Min.Mean.Truth Max.Mean.Truth Min.Mean.Within Max.Mean.Within Min.Mean.Any Max.Mean.Within.1
IL12-mediated signaling events 2 184 87 -0.43 0.094 1000 -1000 -0.055 -1000
Syndecan-1-mediated signaling events 2 77 34 -0.11 0.025 1000 -1000 -0.027 -1000
HIF-1-alpha transcription factor network 2 224 76 -0.27 0.036 1000 -1000 -0.055 -1000
Fc-epsilon receptor I signaling in mast cells 2 258 97 -0.19 0.039 1000 -1000 -0.047 -1000
TRAIL signaling pathway 2 115 48 -0.085 0.028 1000 -1000 -0.03 -1000
Endothelins 2 205 96 -0.17 0.025 1000 -1000 -0.039 -1000
IL23-mediated signaling events 2 146 60 -0.4 0.025 1000 -1000 -0.1 -1000
E-cadherin signaling events 2 12 5 -0.035 0.009 1000 -1000 0.008 -1000
Caspase cascade in apoptosis 1 107 74 -0.067 0.062 1000 -1000 -0.029 -1000
PLK2 and PLK4 events 1 4 3 -0.036 0.025 1000 -1000 -0.024 -1000
Visual signal transduction: Cones 1 59 38 -0.051 0.031 1000 -1000 -0.014 -1000
Osteopontin-mediated events 1 75 38 -0.12 0.025 1000 -1000 -0.031 -1000
Lissencephaly gene (LIS1) in neuronal migration and development 1 63 54 -0.077 0.073 1000 -1000 -0.034 -1000
Signaling events mediated by the Hedgehog family 1 63 52 -0.051 0.05 1000 -1000 -0.024 -1000
Ephrin A reverse signaling 1 10 7 -0.003 0.025 1000 -1000 -0.003 -1000
Thromboxane A2 receptor signaling 1 160 105 -0.14 0.032 1000 -1000 -0.034 -1000
a4b1 and a4b7 Integrin signaling 1 8 5 -0.009 0.012 1000 -1000 0.009 -1000
Arf6 signaling events 1 123 62 -0.067 0.046 1000 -1000 -0.014 -1000
Signaling events mediated by PTP1B 1 136 76 -0.089 0.078 1000 -1000 -0.027 -1000
IL4-mediated signaling events 1 106 91 -0.29 0.24 1000 -1000 -0.12 -1000
Glypican 1 network 1 76 48 -0.11 0.025 1000 -1000 -0.031 -1000
EPO signaling pathway 1 66 55 -0.002 0.072 1000 -1000 -0.031 -1000
amb2 Integrin signaling 1 95 82 -0.064 0.025 1000 -1000 -0.025 -1000
Ceramide signaling pathway 1 128 76 -0.063 0.043 1000 -1000 -0.026 -1000
Reelin signaling pathway 1 84 56 -0.047 0.04 1000 -1000 -0.029 -1000
Ephrin B reverse signaling 1 55 48 -0.056 0.034 1000 -1000 -0.02 -1000
Signaling mediated by p38-gamma and p38-delta 1 17 15 -0.03 0.025 1000 -1000 -0.031 -1000
Signaling mediated by p38-alpha and p38-beta 1 52 44 -0.043 0.058 1000 -1000 -0.02 -1000
Integrins in angiogenesis 1 116 84 -0.1 0.045 1000 -1000 -0.032 -1000
TCR signaling in naïve CD8+ T cells 1 111 93 -0.24 0.27 1000 -1000 -0.037 -1000
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1 114 68 -0.29 0.16 1000 -1000 -0.091 -1000
Stabilization and expansion of the E-cadherin adherens junction 1 92 74 -0.075 0.048 1000 -1000 -0.051 -1000
E-cadherin signaling in the nascent adherens junction 1 77 76 -0.086 0.037 1000 -1000 -0.048 -1000
TCGA08_retinoblastoma 1 9 8 -0.023 0.027 1000 -1000 -0.002 -1000
EGFR-dependent Endothelin signaling events 1 38 21 -0.067 0.033 1000 -1000 -0.02 -1000
Syndecan-4-mediated signaling events 1 119 67 -0.1 0.1 1000 -1000 -0.027 -1000
Plasma membrane estrogen receptor signaling 1 118 86 -0.067 0.055 1000 -1000 -0.045 -1000
Visual signal transduction: Rods 1 66 52 -0.093 0.055 1000 -1000 -0.026 -1000
Class IB PI3K non-lipid kinase events 1 3 3 -0.01 0.01 1000 -1000 -0.012 -1000
Signaling events mediated by Stem cell factor receptor (c-Kit) 1 124 78 -0.16 0.052 1000 -1000 -0.049 -1000
LPA4-mediated signaling events 0 8 12 -0.029 0.003 1000 -1000 -0.02 -1000
ErbB2/ErbB3 signaling events 0 51 65 -0.054 0.033 1000 -1000 -0.042 -1000
Regulation of nuclear SMAD2/3 signaling 0 58 136 -0.047 0.064 1000 -1000 -0.029 -1000
Coregulation of Androgen receptor activity 0 21 76 -0.027 0.049 1000 -1000 -0.026 -1000
Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0 2 23 0.003 0.041 1000 -1000 -0.023 -1000
Nephrin/Neph1 signaling in the kidney podocyte 0 11 34 -0.022 0.045 1000 -1000 -0.023 -1000
Canonical NF-kappaB pathway 0 4 39 -0.007 0.059 1000 -1000 -0.026 -1000
Signaling events mediated by HDAC Class II 0 15 75 -0.026 0.048 1000 -1000 -0.027 -1000
ErbB4 signaling events 0 26 69 -0.042 0.055 1000 -1000 -0.029 -1000
BARD1 signaling events 0 10 57 -0.04 0.065 1000 -1000 -0.03 -1000
Sphingosine 1-phosphate (S1P) pathway 0 7 28 -0.017 0.029 1000 -1000 -0.027 -1000
Circadian rhythm pathway 0 5 22 -0.017 0.044 1000 -1000 -0.039 -1000
JNK signaling in the CD4+ TCR pathway 0 5 17 -0.038 0.046 1000 -1000 -0.023 -1000
Noncanonical Wnt signaling pathway 0 6 26 -0.02 0.025 1000 -1000 -0.031 -1000
Syndecan-2-mediated signaling events 0 42 69 -0.098 0.048 1000 -1000 -0.033 -1000
Cellular roles of Anthrax toxin 0 18 39 -0.047 0.034 1000 -1000 -0.017 -1000
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 0 45 85 -0.12 0.098 1000 -1000 -0.031 -1000
Hedgehog signaling events mediated by Gli proteins 0 33 65 -0.049 0.061 1000 -1000 -0.042 -1000
Presenilin action in Notch and Wnt signaling 0 36 61 -0.049 0.044 1000 -1000 -0.029 -1000
Aurora A signaling 0 24 60 -0.032 0.042 1000 -1000 -0.023 -1000
p75(NTR)-mediated signaling 0 85 125 -0.085 0.052 1000 -1000 -0.051 -1000
Arf6 downstream pathway 0 28 43 -0.029 0.035 1000 -1000 -0.02 -1000
Aurora C signaling 0 0 7 0 0.045 1000 -1000 -0.016 -1000
FOXA2 and FOXA3 transcription factor networks 0 28 46 -0.15 0.03 1000 -1000 -0.07 -1000
BMP receptor signaling 0 69 81 -0.12 0.048 1000 -1000 -0.045 -1000
PLK1 signaling events 0 63 85 -0.023 0.038 1000 -1000 -0.034 -1000
Insulin-mediated glucose transport 0 10 32 -0.029 0.034 1000 -1000 -0.025 -1000
PDGFR-alpha signaling pathway 0 23 44 -0.13 0.054 1000 -1000 -0.029 -1000
mTOR signaling pathway 0 20 53 -0.04 0.038 1000 -1000 -0.028 -1000
IFN-gamma pathway 0 36 68 -0.047 0.037 1000 -1000 -0.046 -1000
Class I PI3K signaling events mediated by Akt 0 34 68 -0.036 0.053 1000 -1000 -0.026 -1000
Nectin adhesion pathway 0 48 63 -0.026 0.056 1000 -1000 -0.037 -1000
Glucocorticoid receptor regulatory network 0 80 114 -0.23 0.068 1000 -1000 -0.047 -1000
Paxillin-independent events mediated by a4b1 and a4b7 0 31 37 -0.051 0.037 1000 -1000 -0.022 -1000
Signaling events mediated by HDAC Class III 0 24 40 -0.052 0.052 1000 -1000 -0.024 -1000
IL1-mediated signaling events 0 47 62 -0.077 0.055 1000 -1000 -0.03 -1000
Signaling events regulated by Ret tyrosine kinase 0 35 82 -0.058 0.05 1000 -1000 -0.04 -1000
S1P5 pathway 0 5 17 -0.017 0.025 1000 -1000 -0.015 -1000
ceramide signaling pathway 0 31 49 -0.057 0.041 1000 -1000 -0.03 -1000
RXR and RAR heterodimerization with other nuclear receptor 0 21 52 -0.007 0.056 1000 -1000 -0.04 -1000
HIF-2-alpha transcription factor network 0 4 43 -0.053 0.055 1000 -1000 -0.039 -1000
Role of Calcineurin-dependent NFAT signaling in lymphocytes 0 31 83 -0.016 0.048 1000 -1000 -0.02 -1000
S1P1 pathway 0 8 36 -0.001 0.04 1000 -1000 -0.033 -1000
Signaling events mediated by HDAC Class I 0 31 104 -0.038 0.061 1000 -1000 -0.026 -1000
TCGA08_p53 0 5 7 -0.01 0.03 1000 -1000 -0.012 -1000
FoxO family signaling 0 29 64 -0.044 0.05 1000 -1000 -0.05 -1000
FAS signaling pathway (CD95) 0 33 47 -0.082 0.038 1000 -1000 -0.027 -1000
Retinoic acid receptors-mediated signaling 0 21 58 -0.009 0.045 1000 -1000 -0.033 -1000
Paxillin-dependent events mediated by a4b1 0 22 36 -0.031 0.041 1000 -1000 -0.023 -1000
Atypical NF-kappaB pathway 0 18 31 -0.031 0.035 1000 -1000 -0.023 -1000
Syndecan-3-mediated signaling events 0 24 35 -0.098 0.037 1000 -1000 -0.034 -1000
IL2 signaling events mediated by PI3K 0 22 58 -0.028 0.034 1000 -1000 -0.032 -1000
HIV-1 Nef: Negative effector of Fas and TNF-alpha 0 39 45 -0.1 0.041 1000 -1000 -0.035 -1000
Canonical Wnt signaling pathway 0 19 51 -0.074 0.054 1000 -1000 -0.036 -1000
EPHB forward signaling 0 59 85 -0.05 0.06 1000 -1000 -0.053 -1000
Regulation of p38-alpha and p38-beta 0 38 54 -0.056 0.025 1000 -1000 -0.033 -1000
Effects of Botulinum toxin 0 8 26 -0.02 0.03 1000 -1000 -0.012 -1000
Glypican 2 network 0 3 4 0 0.003 1000 -1000 0 -1000
Calcium signaling in the CD4+ TCR pathway 0 20 31 -0.087 0.028 1000 -1000 -0.045 -1000
Nongenotropic Androgen signaling 0 30 52 -0.08 0.042 1000 -1000 -0.025 -1000
Signaling events mediated by VEGFR1 and VEGFR2 0 50 125 -0.033 0.063 1000 -1000 -0.033 -1000
IL27-mediated signaling events 0 42 51 -0.11 0.035 1000 -1000 -0.043 -1000
Wnt signaling 0 4 7 -0.002 0.025 1000 -1000 -0.012 -1000
TCGA08_rtk_signaling 0 20 26 -0.036 0.073 1000 -1000 -0.006 -1000
LPA receptor mediated events 0 86 102 -0.16 0.076 1000 -1000 -0.036 -1000
IL6-mediated signaling events 0 50 75 -0.11 0.076 1000 -1000 -0.036 -1000
Sumoylation by RanBP2 regulates transcriptional repression 0 0 27 -0.009 0.053 1000 -1000 -0.032 -1000
IL2 signaling events mediated by STAT5 0 14 22 -0.092 0.033 1000 -1000 -0.032 -1000
Class I PI3K signaling events 0 69 73 -0.12 0.03 1000 -1000 -0.039 -1000
Arf6 trafficking events 0 52 71 -0.03 0.028 1000 -1000 -0.022 -1000
Regulation of Telomerase 0 69 102 -0.096 0.049 1000 -1000 -0.04 -1000
BCR signaling pathway 0 82 99 -0.081 0.056 1000 -1000 -0.043 -1000
IGF1 pathway 0 8 57 -0.027 0.068 1000 -1000 -0.029 -1000
Insulin Pathway 0 25 74 -0.027 0.053 1000 -1000 -0.041 -1000
VEGFR1 specific signals 0 15 56 -0.041 0.025 1000 -1000 -0.037 -1000
S1P3 pathway 0 18 42 -0.013 0.029 1000 -1000 -0.024 -1000
Angiopoietin receptor Tie2-mediated signaling 0 14 88 -0.023 0.055 1000 -1000 -0.058 -1000
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0 5 33 -0.01 0.065 1000 -1000 -0.027 -1000
Rapid glucocorticoid signaling 0 9 20 -0.033 0.03 1000 -1000 -0.013 -1000
Neurotrophic factor-mediated Trk receptor signaling 0 49 120 -0.033 0.057 1000 -1000 -0.035 -1000
PDGFR-beta signaling pathway 0 48 97 -0.047 0.056 1000 -1000 -0.045 -1000
Signaling events mediated by PRL 0 23 34 -0.043 0.035 1000 -1000 -0.037 -1000
E-cadherin signaling in keratinocytes 0 22 43 -0.038 0.026 1000 -1000 -0.023 -1000
FOXM1 transcription factor network 0 40 51 -0.14 0.035 1000 -1000 -0.11 -1000
S1P4 pathway 0 11 25 -0.004 0.063 1000 -1000 -0.019 -1000
p38 MAPK signaling pathway 0 32 44 -0.036 0.025 1000 -1000 -0.02 -1000
Arf1 pathway 0 2 54 -0.005 0.051 1000 -1000 -0.014 -1000
Alternative NF-kappaB pathway 0 8 13 0 0.036 1000 -1000 0 -1000
Regulation of Androgen receptor activity 0 29 70 -0.064 0.034 1000 -1000 -0.044 -1000
Ras signaling in the CD4+ TCR pathway 0 10 17 -0.003 0.029 1000 -1000 -0.018 -1000
Aurora B signaling 0 23 67 -0.064 0.063 1000 -1000 -0.034 -1000
Total 48 6233 7203 -8.9 6.3 131000 -131000 -4.2 -131000
IL12-mediated signaling events

Figure S1.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S1.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IL12/IL12R/TYK2/JAK2/SOCS1 -0.095 0.16 -10000 0 -0.4 3 3
TBX21 -0.32 0.5 -10000 0 -1.3 3 3
B2M -0.037 0.12 -10000 0 -0.27 3 3
TYK2 -0.003 0.034 -10000 0 -10000 0 0
IL12RB1 -0.003 0.034 -10000 0 -10000 0 0
GADD45B -0.21 0.34 -10000 0 -0.83 3 3
IL12RB2 -0.088 0.12 -10000 0 -0.24 6 6
GADD45G -0.22 0.36 -10000 0 -0.8 4 4
natural killer cell activation -0.009 0.014 -10000 0 -0.038 2 2
RELB 0.025 0 -10000 0 -10000 0 0
RELA 0.025 0 -10000 0 -10000 0 0
IL18 0.001 0.083 -10000 0 -0.32 1 1
IL2RA 0.023 0.006 -10000 0 -10000 0 0
IFNG -0.015 0.082 -10000 0 -0.19 3 3
STAT3 (dimer) -0.23 0.35 -10000 0 -0.78 4 4
HLA-DRB5 -0.044 0.11 -10000 0 -0.27 3 3
FASLG -0.3 0.46 -10000 0 -1.2 3 3
NF kappa B2 p52/RelB -0.29 0.48 -10000 0 -1.3 3 3
CD4 0.019 0.016 -10000 0 -10000 0 0
SOCS1 0.001 0.08 -10000 0 -0.31 1 1
EntrezGene:6955 -0.005 0.014 -10000 0 -0.054 1 1
CD3D 0.001 0.057 -10000 0 -0.2 1 1
CD3E 0.014 0.026 -10000 0 -10000 0 0
CD3G -0.02 0.093 -10000 0 -0.25 2 2
IL12Rbeta2/JAK2 -0.041 0.083 -10000 0 -0.17 4 4
CCL3 -0.34 0.56 -10000 0 -1.5 3 3
CCL4 -0.43 0.6 -10000 0 -1.3 5 5
HLA-A 0.007 0.057 -10000 0 -0.2 1 1
IL18/IL18R -0.029 0.14 -10000 0 -0.35 2 2
NOS2 -0.24 0.38 -10000 0 -0.98 3 3
IL12/IL12R/TYK2/JAK2/SPHK2 -0.081 0.14 -10000 0 -0.33 3 3
IL1R1 -0.29 0.46 -10000 0 -1.2 3 3
IL4 0.009 0.078 -10000 0 -0.28 1 1
JAK2 -0.004 0.031 -10000 0 -10000 0 0
EntrezGene:6957 -0.004 0.014 -10000 0 -0.053 1 1
TCR/CD3/MHC I/CD8 -0.078 0.21 -10000 0 -0.56 2 2
RAB7A -0.18 0.29 -10000 0 -0.64 4 4
lysosomal transport -0.17 0.27 -10000 0 -0.6 4 4
FOS -0.32 0.45 -10000 0 -0.89 5 5
STAT4 (dimer) -0.26 0.41 -10000 0 -0.93 4 4
STAT5A (dimer) -0.29 0.48 -10000 0 -1.3 3 3
GZMA -0.29 0.46 -10000 0 -1.2 3 3
GZMB -0.32 0.54 -10000 0 -1.4 3 3
HLX 0 0 -10000 0 -10000 0 0
LCK -0.33 0.52 -10000 0 -1.4 3 3
TCR/CD3/MHC II/CD4 -0.095 0.18 -10000 0 -0.33 5 5
IL2/IL2R 0.04 0.054 -10000 0 -10000 0 0
MAPK14 -0.22 0.36 -10000 0 -0.78 4 4
CCR5 -0.21 0.35 -10000 0 -0.74 4 4
IL1B -0.083 0.14 -10000 0 -0.28 5 5
STAT6 -0.059 0.098 -10000 0 -10000 0 0
STAT4 -0.03 0.12 -10000 0 -0.27 3 3
STAT3 0.001 0.08 -10000 0 -0.31 1 1
STAT1 0.012 0.051 -10000 0 -0.19 1 1
NFKB1 0.004 0.081 -10000 0 -0.31 1 1
NFKB2 0.023 0.006 -10000 0 -10000 0 0
IL12B -0.02 0.085 -10000 0 -0.33 1 1
CD8A -0.003 0.013 -10000 0 -0.054 1 1
CD8B -0.003 0.013 -10000 0 -0.054 1 1
T-helper 1 cell differentiation 0 0 -10000 0 -10000 0 0
natural killer cell mediated cytotoxicity 0.094 0.16 0.39 3 -10000 0 3
IL2RB 0.012 0.051 -10000 0 -0.19 1 1
proteasomal ubiquitin-dependent protein catabolic process -0.23 0.37 -10000 0 -0.84 4 4
IL2RG 0.025 0 -10000 0 -10000 0 0
IL12 -0.036 0.099 -10000 0 -0.22 3 3
STAT5A 0.022 0.008 -10000 0 -10000 0 0
CD247 -0.004 0.014 -10000 0 -0.054 1 1
IL2 0.012 0.051 -10000 0 -0.19 1 1
SPHK2 0.025 0 -10000 0 -10000 0 0
FRAP1 0.023 0.006 -10000 0 -10000 0 0
IL12A -0.033 0.1 -10000 0 -0.28 2 2
IL12/IL12R/TYK2/JAK2 -0.35 0.57 -10000 0 -1.5 3 3
MAP2K3 -0.23 0.36 -10000 0 -0.79 4 4
RIPK2 0.025 0 -10000 0 -10000 0 0
MAP2K6 -0.22 0.37 -10000 0 -0.79 4 4
regulation of dendritic cell antigen processing and presentation 0 0 -10000 0 -10000 0 0
HLA-DRA -0.11 0.15 -10000 0 -0.28 7 7
IL18RAP -0.034 0.12 -10000 0 -0.27 3 3
IL12Rbeta1/TYK2 -0.002 0.046 -10000 0 -10000 0 0
EOMES -0.04 0.25 -10000 0 -0.97 1 1
STAT1 (dimer) -0.21 0.34 -10000 0 -0.87 3 3
T cell proliferation -0.18 0.26 -10000 0 -0.62 4 4
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
IL18R1 -0.012 0.093 -10000 0 -0.25 2 2
CD8-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA -0.2 0.31 -10000 0 -0.69 4 4
ATF2 -0.2 0.33 -10000 0 -0.72 4 4
Syndecan-1-mediated signaling events

Figure S2.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S2.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.025 0 -9999 0 -10000 0 0
CCL5 -0.009 0.093 -9999 0 -0.25 2 2
SDCBP 0.012 0.051 -9999 0 -0.19 1 1
FGFR/FGF2/Syndecan-1 -0.1 0.12 -9999 0 -0.28 4 4
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
RP11-540L11.1 0 0 -9999 0 -10000 0 0
Syndecan-1/Laminin-5 -0.1 0.12 -9999 0 -0.3 3 3
Syndecan-1/Syntenin -0.1 0.12 -9999 0 -0.3 3 3
MAPK3 -0.099 0.11 -9999 0 -0.28 3 3
HGF/MET 0.023 0.018 -9999 0 -10000 0 0
TGFB1/TGF beta receptor Type II 0.025 0 -9999 0 -10000 0 0
BSG 0.025 0 -9999 0 -10000 0 0
keratinocyte migration -0.1 0.11 -9999 0 -0.29 3 3
Syndecan-1/RANTES -0.11 0.14 -9999 0 -0.32 4 4
Syndecan-1/CD147 -0.1 0.12 -9999 0 -0.29 3 3
Syndecan-1/Syntenin/PIP2 -0.098 0.11 -9999 0 -0.28 3 3
LAMA5 0.012 0.051 -9999 0 -0.19 1 1
positive regulation of cell-cell adhesion -0.097 0.11 -9999 0 -0.28 3 3
MMP7 -0.085 0.15 -9999 0 -0.27 6 6
HGF 0.019 0.011 -9999 0 -10000 0 0
Syndecan-1/CASK -0.099 0.11 -9999 0 -0.26 4 4
Syndecan-1/HGF/MET -0.068 0.097 -9999 0 -0.26 2 2
regulation of cell adhesion -0.1 0.11 -9999 0 -0.3 2 2
HPSE -0.043 0.12 -9999 0 -0.25 4 4
positive regulation of cell migration -0.1 0.12 -9999 0 -0.28 4 4
SDC1 -0.1 0.12 -9999 0 -0.28 4 4
Syndecan-1/Collagen -0.1 0.12 -9999 0 -0.28 4 4
PPIB 0.004 0.081 -9999 0 -0.31 1 1
MET 0.016 0.012 -9999 0 -10000 0 0
PRKACA 0.025 0 -9999 0 -10000 0 0
MMP9 -0.064 0.14 -9999 0 -0.26 5 5
MAPK1 -0.1 0.11 -9999 0 -0.28 3 3
homophilic cell adhesion -0.1 0.12 -9999 0 -0.3 3 3
MMP1 -0.001 0.07 -9999 0 -0.19 2 2
HIF-1-alpha transcription factor network

Figure S3.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S3.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PKM2 -0.17 0.35 -9999 0 -0.72 4 4
HDAC7 -0.001 0.004 -9999 0 -10000 0 0
HIF1A/ARNT/Cbp/p300/Src-1 -0.15 0.34 -9999 0 -0.62 4 4
SMAD4 0.024 0.006 -9999 0 -10000 0 0
ID2 -0.17 0.35 -9999 0 -0.72 4 4
AP1 -0.03 0.099 -9999 0 -0.2 4 4
ABCG2 -0.17 0.35 -9999 0 -0.72 4 4
HIF1A -0.011 0.074 -9999 0 -10000 0 0
TFF3 -0.19 0.36 -9999 0 -0.75 4 4
GATA2 0.019 0.019 -9999 0 -10000 0 0
AKT1 -0.033 0.084 -9999 0 -10000 0 0
response to hypoxia -0.046 0.074 -9999 0 -0.14 5 5
MCL1 -0.16 0.35 -9999 0 -0.72 4 4
NDRG1 -0.17 0.36 -9999 0 -0.74 4 4
SERPINE1 -0.15 0.36 -9999 0 -0.74 4 4
FECH -0.17 0.35 -9999 0 -0.72 4 4
FURIN -0.17 0.35 -9999 0 -0.72 4 4
NCOA2 0.026 0 -9999 0 -10000 0 0
EP300 -0.066 0.13 -9999 0 -0.28 3 3
HMOX1 -0.19 0.38 -9999 0 -0.77 4 4
BHLHE40 -0.18 0.34 -9999 0 -0.72 4 4
BHLHE41 -0.18 0.34 -9999 0 -0.72 4 4
HIF1A/ARNT/SMAD3/SMAD4/SP1 0.011 0.13 -9999 0 -10000 0 0
ENG -0.026 0.097 -9999 0 -10000 0 0
JUN -0.006 0.069 -9999 0 -0.18 2 2
RORA -0.18 0.36 -9999 0 -0.75 4 4
ABCB1 -0.27 0.44 -9999 0 -0.9 5 5
TFRC -0.19 0.34 -9999 0 -0.72 4 4
CXCR4 -0.2 0.38 -9999 0 -0.8 4 4
TF -0.17 0.35 -9999 0 -0.72 4 4
CITED2 -0.18 0.35 -9999 0 -0.72 4 4
HIF1A/ARNT -0.14 0.43 -9999 0 -0.79 4 4
LDHA -0.051 0.19 -9999 0 -0.75 1 1
ETS1 -0.18 0.32 -9999 0 -0.68 4 4
PGK1 -0.18 0.36 -9999 0 -0.75 4 4
NOS2 -0.18 0.34 -9999 0 -0.72 4 4
ITGB2 -0.19 0.37 -9999 0 -0.77 4 4
ALDOA -0.16 0.35 -9999 0 -0.72 4 4
Cbp/p300/CITED2 -0.22 0.38 -9999 0 -0.76 4 4
FOS -0.036 0.12 -9999 0 -0.27 3 3
HK2 -0.17 0.35 -9999 0 -0.72 4 4
SP1 -0.012 0.065 -9999 0 -0.13 2 2
GCK -0.14 0.33 -9999 0 -0.96 2 2
HK1 -0.17 0.35 -9999 0 -0.72 4 4
NPM1 -0.16 0.35 -9999 0 -0.72 4 4
EGLN1 -0.16 0.35 -9999 0 -0.72 4 4
CREB1 0.03 0.001 -9999 0 -10000 0 0
PGM1 -0.16 0.35 -9999 0 -0.72 4 4
SMAD3 0.026 0 -9999 0 -10000 0 0
EDN1 -0.14 0.29 -9999 0 -1.1 1 1
IGFBP1 -0.16 0.36 -9999 0 -0.75 4 4
VEGFA -0.16 0.28 -9999 0 -0.56 4 4
HIF1A/JAB1 0.007 0.06 -9999 0 -10000 0 0
CP -0.18 0.36 -9999 0 -0.74 4 4
CXCL12 -0.19 0.37 -9999 0 -0.77 4 4
COPS5 0.026 0 -9999 0 -10000 0 0
SMAD3/SMAD4 0.036 0.009 -9999 0 -10000 0 0
BNIP3 -0.19 0.37 -9999 0 -0.78 4 4
EGLN3 -0.17 0.36 -9999 0 -0.74 4 4
CA9 -0.18 0.37 -9999 0 -0.75 4 4
TERT -0.18 0.35 -9999 0 -0.72 4 4
ENO1 -0.17 0.35 -9999 0 -0.72 4 4
PFKL -0.18 0.35 -9999 0 -0.72 4 4
NCOA1 0.025 0 -9999 0 -10000 0 0
ADM -0.18 0.36 -9999 0 -0.73 4 4
ARNT -0.01 0.075 -9999 0 -10000 0 0
HNF4A 0.006 0.049 -9999 0 -0.12 2 2
ADFP -0.19 0.38 -9999 0 -0.8 4 4
SLC2A1 -0.15 0.3 -9999 0 -0.57 4 4
LEP -0.15 0.35 -9999 0 -0.72 4 4
HIF1A/ARNT/Cbp/p300 -0.16 0.35 -9999 0 -0.64 4 4
EPO -0.097 0.21 -9999 0 -10000 0 0
CREBBP -0.051 0.12 -9999 0 -0.28 2 2
HIF1A/ARNT/Cbp/p300/HDAC7 -0.16 0.34 -9999 0 -0.63 4 4
PFKFB3 -0.17 0.35 -9999 0 -0.72 4 4
NT5E -0.17 0.35 -9999 0 -0.72 4 4
Fc-epsilon receptor I signaling in mast cells

Figure S4.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S4.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PPAP2A 0.003 0.081 -10000 0 -0.31 1 1
LAT2 -0.11 0.2 0.14 2 -0.5 3 5
AP1 -0.18 0.23 -10000 0 -0.58 3 3
mol:PIP3 -0.088 0.24 0.44 1 -0.47 3 4
IKBKB -0.047 0.14 0.3 1 -0.29 2 3
AKT1 -0.14 0.1 -10000 0 -0.3 3 3
IKBKG -0.047 0.14 0.3 1 -0.29 2 3
MS4A2 -0.11 0.14 -10000 0 -0.24 8 8
mol:Sphingosine-1-phosphate 0 0 -10000 0 -10000 0 0
PIK3CA 0.024 0.001 -10000 0 -10000 0 0
MAP3K1 -0.13 0.21 -10000 0 -0.53 3 3
mol:Ca2+ -0.06 0.19 0.4 1 -0.34 3 4
LYN 0.017 0.016 -10000 0 -10000 0 0
CBLB -0.15 0.18 -10000 0 -0.5 3 3
SHC1 0.024 0.006 -10000 0 -10000 0 0
RasGAP/p62DOK 0.014 0.066 -10000 0 -0.16 1 1
positive regulation of cell migration -0.013 0.028 -10000 0 -0.12 1 1
INPP5D 0 0 -10000 0 -10000 0 0
PLD2 -0.16 0.11 -10000 0 -0.33 3 3
PTPN13 -0.14 0.2 -10000 0 -0.54 3 3
PTPN11 0.001 0.029 -10000 0 -10000 0 0
GO:0007205 0 0 -10000 0 -10000 0 0
regulation of mast cell degranulation -0.1 0.12 -10000 0 -0.32 3 3
SYK -0.035 0.12 -10000 0 -0.28 3 3
GRB2 0.022 0.008 -10000 0 -10000 0 0
LAT/PLCgamma1/GRB2/SLP76/GADs -0.12 0.21 -10000 0 -0.49 3 3
LAT -0.14 0.18 -10000 0 -0.5 3 3
PAK2 -0.14 0.22 -10000 0 -0.56 3 3
NFATC2 -0.076 0.1 -10000 0 -0.45 1 1
HRAS -0.16 0.24 -10000 0 -0.62 3 3
GAB2 0.025 0 -10000 0 -10000 0 0
PLA2G1B 0.033 0.031 -10000 0 -10000 0 0
Fc epsilon R1 -0.17 0.14 -10000 0 -0.25 10 10
Antigen/IgE/Fc epsilon R1 -0.15 0.12 -10000 0 -0.23 10 10
mol:GDP -0.16 0.26 -10000 0 -0.66 3 3
JUN -0.003 0.07 -10000 0 -0.19 2 2
mol:Ca++ 0 0 -10000 0 -10000 0 0
PIK3R1 0.022 0.006 -10000 0 -10000 0 0
FOS -0.033 0.12 -10000 0 -0.27 3 3
Antigen/IgE/Fc epsilon R1/LYN/SYK -0.15 0.18 -10000 0 -0.52 3 3
CHUK -0.053 0.14 0.3 1 -0.26 3 4
KLRG1 -0.14 0.16 -10000 0 -0.46 3 3
VAV1 -0.16 0.19 -10000 0 -0.54 3 3
calcium-dependent protein kinase C activity 0 0 -10000 0 -10000 0 0
CBL -0.15 0.18 -10000 0 -0.5 3 3
negative regulation of mast cell degranulation -0.14 0.15 -10000 0 -0.43 3 3
BTK -0.17 0.29 -10000 0 -0.7 3 3
Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK -0.18 0.19 -10000 0 -0.35 7 7
GAB2/PI3K/SHP2 -0.16 0.1 -10000 0 -0.32 3 3
Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP -0.16 0.17 -10000 0 -0.33 6 6
RAF1 0.039 0.035 -10000 0 -10000 0 0
Fc epsilon R1/FcgammaRIIB/SHIP -0.18 0.15 -10000 0 -0.25 11 11
FCER1G -0.038 0.11 -10000 0 -0.22 4 4
FCER1A -0.15 0.16 -10000 0 -0.28 9 9
Antigen/IgE/Fc epsilon R1/Fyn -0.15 0.13 -10000 0 -0.22 11 11
MAPK3 0.032 0.032 -10000 0 -10000 0 0
MAPK1 0.033 0.03 -10000 0 -10000 0 0
NFKB1 0.004 0.081 -10000 0 -0.31 1 1
MAPK8 -0.087 0.22 -10000 0 -0.64 2 2
DUSP1 -0.024 0.1 -10000 0 -0.23 3 3
NF-kappa-B/RelA -0.042 0.068 -10000 0 -0.18 2 2
actin cytoskeleton reorganization -0.13 0.21 -10000 0 -0.55 3 3
mol:Glucocorticoid Dexamethasone 0 0 -10000 0 -10000 0 0
PI3K -0.14 0.22 -10000 0 -0.55 3 3
FER -0.15 0.18 -10000 0 -0.5 3 3
RELA 0.025 0 -10000 0 -10000 0 0
ITK -0.058 0.12 -10000 0 -0.5 1 1
SOS1 0.025 0 -10000 0 -10000 0 0
PLCG1 -0.16 0.26 -10000 0 -0.64 3 3
cytokine secretion -0.031 0.049 -10000 0 -0.13 2 2
SPHK1 -0.13 0.16 -10000 0 -0.53 2 2
PTK2 -0.14 0.22 -10000 0 -0.58 3 3
NTAL/PLCgamma1/GRB2/SLP76/GADs -0.13 0.22 -10000 0 -0.5 3 3
EDG1 -0.013 0.028 -10000 0 -0.12 1 1
mol:DAG -0.1 0.23 0.32 1 -0.48 3 4
MAP2K2 0.03 0.031 -10000 0 -10000 0 0
MAP2K1 0.03 0.031 -10000 0 -10000 0 0
MAP2K7 0.025 0 -10000 0 -10000 0 0
KLRG1/SHP2 -0.14 0.14 -10000 0 -0.42 3 3
MAP2K4 -0.019 0.18 -10000 0 -0.71 1 1
Fc epsilon R1/FcgammaRIIB -0.19 0.16 -10000 0 -0.27 11 11
mol:Choline -0.16 0.11 -10000 0 -0.33 3 3
SHC/Grb2/SOS1 -0.12 0.17 -10000 0 -0.42 3 3
FYN -0.001 0.07 -10000 0 -0.19 2 2
DOK1 0.025 0 -10000 0 -10000 0 0
PXN -0.13 0.2 -10000 0 -0.54 3 3
HCLS1 -0.16 0.2 -10000 0 -0.47 4 4
PRKCB -0.068 0.18 0.34 1 -0.35 3 4
FCGR2B -0.065 0.14 -10000 0 -0.26 5 5
IGHE -0.005 0.007 -10000 0 -10000 0 0
KLRG1/SHIP -0.14 0.15 -10000 0 -0.44 3 3
LCP2 0.008 0.051 -10000 0 -0.19 1 1
PLA2G4A -0.17 0.2 -10000 0 -0.43 5 5
RASA1 0.023 0.006 -10000 0 -10000 0 0
mol:Phosphatidic acid -0.16 0.11 -10000 0 -0.33 3 3
IKK complex -0.039 0.12 0.28 1 -0.22 2 3
WIPF1 0 0 -10000 0 -10000 0 0
TRAIL signaling pathway

Figure S5.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S5.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TNFSF10 -0.085 0.15 -9999 0 -0.27 6 6
positive regulation of NF-kappaB transcription factor activity -0.045 0.11 -9999 0 -0.18 6 6
MAP2K4 -0.039 0.12 -9999 0 -0.42 1 1
IKBKB 0.025 0 -9999 0 -10000 0 0
TNFRSF10B 0.023 0.006 -9999 0 -10000 0 0
TNFRSF10A 0.003 0.081 -9999 0 -0.31 1 1
SMPD1 -0.05 0.098 -9999 0 -0.18 5 5
IKBKG 0.025 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
TNFRSF10D 0.023 0.006 -9999 0 -10000 0 0
TRAIL/TRAILR2 -0.045 0.11 -9999 0 -0.18 6 6
TRAIL/TRAILR3 -0.061 0.12 -9999 0 -0.19 7 7
TRAIL/TRAILR1 -0.06 0.11 -9999 0 -0.19 7 7
TRAIL/TRAILR4 -0.045 0.11 -9999 0 -0.18 6 6
TRAIL/TRAILR1/DAP3/GTP -0.028 0.09 -9999 0 -0.16 4 4
IKK complex -0.045 0.1 -9999 0 -0.3 2 2
RIPK1 0.025 0 -9999 0 -10000 0 0
response to oxidative stress 0 0 -9999 0 -10000 0 0
DAP3/GTP 0.016 0.006 -9999 0 -10000 0 0
MAPK3 -0.062 0.082 -9999 0 -0.18 5 5
MAP3K1 -0.037 0.13 -9999 0 -0.44 1 1
TRAILR4 (trimer) 0.023 0.006 -9999 0 -10000 0 0
TRADD 0.023 0.006 -9999 0 -10000 0 0
TRAILR1 (trimer) 0.003 0.08 -9999 0 -0.31 1 1
TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 -0.056 0.11 -9999 0 -0.26 2 2
CFLAR 0.025 0 -9999 0 -10000 0 0
MAPK1 -0.076 0.088 -9999 0 -0.21 4 4
TRAIL/TRAILR1/FADD/TRADD/RIP -0.023 0.1 -9999 0 -0.16 4 4
mol:ceramide -0.05 0.098 -9999 0 -0.18 5 5
FADD 0.025 0 -9999 0 -10000 0 0
MAPK8 -0.046 0.11 -9999 0 -0.41 1 1
TRAF2 0.023 0.006 -9999 0 -10000 0 0
TRAILR3 (trimer) 0.003 0.08 -9999 0 -0.31 1 1
CHUK 0.003 0.081 -9999 0 -0.31 1 1
TRAIL/TRAILR1/FADD -0.04 0.1 -9999 0 -0.18 5 5
DAP3 0.022 0.008 -9999 0 -10000 0 0
CASP10 -0.053 0.084 -9999 0 -0.21 3 3
JNK cascade -0.045 0.11 -9999 0 -0.18 6 6
TRAIL (trimer) -0.085 0.15 -9999 0 -0.27 6 6
TNFRSF10C 0.003 0.081 -9999 0 -0.31 1 1
TRAIL/TRAILR1/DAP3/GTP/FADD -0.02 0.091 -9999 0 -0.15 4 4
TRAIL/TRAILR2/FADD -0.025 0.1 -9999 0 -0.18 4 4
cell death -0.05 0.097 -9999 0 -0.18 5 5
TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 -0.044 0.1 -9999 0 -0.26 2 2
TRAILR2 (trimer) 0.023 0.006 -9999 0 -10000 0 0
CASP8 0.028 0.03 -9999 0 -10000 0 0
negative regulation of caspase activity 0 0 -9999 0 -10000 0 0
TRAIL/TRAILR2/FADD/TRADD/RIP -0.008 0.1 -9999 0 -0.16 3 3
Endothelins

Figure S6.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S6.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 -0.077 0.13 -10000 0 -0.36 2 2
PTK2B 0.023 0.006 -10000 0 -10000 0 0
mol:Ca2+ -0.1 0.13 -10000 0 -10000 0 0
EDN1 -0.05 0.13 -10000 0 -0.33 2 2
EDN3 -0.022 0.1 -10000 0 -0.23 3 3
EDN2 -0.073 0.14 -10000 0 -0.28 5 5
HRAS/GDP -0.079 0.18 0.24 1 -0.34 3 4
ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.064 0.11 -10000 0 -0.23 4 4
ADCY4 -0.067 0.12 -10000 0 -0.32 2 2
ADCY5 -0.055 0.12 -10000 0 -0.45 1 1
ADCY6 -0.051 0.1 -10000 0 -0.38 1 1
ADCY7 -0.047 0.1 -10000 0 -0.38 1 1
ADCY1 -0.051 0.1 -10000 0 -0.38 1 1
ADCY2 -0.068 0.12 -10000 0 -0.26 3 3
ADCY3 -0.051 0.1 -10000 0 -0.38 1 1
ADCY8 -0.057 0.1 -10000 0 -0.38 1 1
ADCY9 -0.05 0.1 -10000 0 -0.38 1 1
arachidonic acid secretion -0.15 0.21 -10000 0 -0.45 4 4
ETB receptor/Endothelin-1/Gq/GTP -0.073 0.13 -10000 0 -0.3 3 3
GNAO1 0.023 0.006 -10000 0 -10000 0 0
HRAS 0.025 0.001 -10000 0 -10000 0 0
ETA receptor/Endothelin-1/G12/GTP -0.038 0.14 -10000 0 -0.33 2 2
ETA receptor/Endothelin-1/Gs/GTP -0.032 0.12 -10000 0 -0.4 1 1
mol:GTP -0.001 0.004 -10000 0 -10000 0 0
COL3A1 -0.091 0.18 -10000 0 -0.48 2 2
EDNRB -0.064 0.14 -10000 0 -0.27 5 5
response to oxidative stress 0 0 -10000 0 -10000 0 0
CYSLTR2 -0.08 0.14 -10000 0 -0.36 2 2
CYSLTR1 -0.095 0.18 -10000 0 -0.44 3 3
SLC9A1 -0.037 0.084 -10000 0 -0.21 2 2
mol:GDP -0.089 0.18 0.24 1 -0.36 3 4
SLC9A3 -0.14 0.25 -10000 0 -0.63 3 3
RAF1 -0.1 0.17 -10000 0 -0.34 4 4
JUN -0.097 0.14 -10000 0 -10000 0 0
JAK2 -0.049 0.1 -10000 0 -0.27 2 2
mol:IP3 -0.084 0.13 -10000 0 -0.27 4 4
ETA receptor/Endothelin-1 -0.068 0.17 -10000 0 -0.36 3 3
PLCB1 -0.01 0.092 -10000 0 -0.25 2 2
PLCB2 0.006 0.052 -10000 0 -0.19 1 1
ETA receptor/Endothelin-3 -0.044 0.11 -10000 0 -0.19 5 5
FOS -0.15 0.28 -10000 0 -0.83 2 2
Gai/GDP 0.005 0.044 -10000 0 -10000 0 0
CRK 0.022 0.008 -10000 0 -10000 0 0
mol:Ca ++ -0.12 0.19 -10000 0 -0.45 3 3
BCAR1 0.024 0.006 -10000 0 -10000 0 0
PRKCB1 -0.072 0.17 0.2 2 -0.32 3 5
GNAQ -0.002 0.004 -10000 0 -10000 0 0
GNAZ 0.025 0 -10000 0 -10000 0 0
GNAL 0.022 0.008 -10000 0 -10000 0 0
Gs family/GDP -0.075 0.15 0.22 1 -0.28 3 4
ETA receptor/Endothelin-1/Gq/GTP -0.062 0.11 -10000 0 -0.25 3 3
MAPK14 -0.077 0.12 -10000 0 -0.29 3 3
TRPC6 -0.11 0.13 -10000 0 -10000 0 0
GNAI2 0.025 0 -10000 0 -10000 0 0
GNAI3 0.023 0.006 -10000 0 -10000 0 0
GNAI1 -0.002 0.08 -10000 0 -0.31 1 1
ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.078 0.13 -10000 0 -0.3 3 3
ETB receptor/Endothelin-2 -0.092 0.17 -10000 0 -0.25 7 7
ETB receptor/Endothelin-3 -0.062 0.12 -10000 0 -0.19 7 7
ETB receptor/Endothelin-1 -0.081 0.15 -10000 0 -0.35 3 3
MAPK3 -0.14 0.25 -10000 0 -0.6 3 3
MAPK1 -0.14 0.25 -10000 0 -0.6 3 3
Rac1/GDP -0.063 0.16 0.24 1 -0.36 2 3
cAMP biosynthetic process -0.051 0.11 -10000 0 -0.35 1 1
MAPK8 -0.11 0.15 -10000 0 -0.39 1 1
SRC 0.025 0 -10000 0 -10000 0 0
ETB receptor/Endothelin-1/Gi/GTP -0.054 0.1 -10000 0 -0.25 3 3
p130Cas/CRK/Src/PYK2 -0.085 0.15 -10000 0 -0.43 1 1
mol:K + 0 0 -10000 0 -10000 0 0
G12/GDP -0.063 0.16 0.24 1 -0.36 2 3
COL1A2 -0.11 0.24 -10000 0 -0.67 2 2
EntrezGene:2778 0 0 -10000 0 -10000 0 0
ETA receptor/Endothelin-2 -0.084 0.12 -10000 0 -0.25 5 5
mol:DAG -0.084 0.13 -10000 0 -0.27 4 4
MAP2K2 -0.12 0.2 -10000 0 -0.47 3 3
MAP2K1 -0.12 0.2 -10000 0 -0.47 3 3
EDNRA -0.038 0.11 -10000 0 -0.29 2 2
positive regulation of muscle contraction -0.023 0.15 0.21 2 -0.32 2 4
Gq family/GDP -0.069 0.16 0.23 1 -0.28 4 5
HRAS/GTP -0.087 0.15 -10000 0 -0.31 3 3
PRKCH -0.098 0.13 -10000 0 -0.35 2 2
RAC1 0.019 0.011 -10000 0 -10000 0 0
PRKCA -0.052 0.12 0.23 1 -0.24 2 3
PRKCB -0.083 0.12 -10000 0 -0.28 3 3
PRKCE -0.074 0.14 0.18 1 -0.28 3 4
PRKCD -0.086 0.12 -10000 0 -0.32 2 2
PRKCG -0.094 0.14 -10000 0 -0.32 3 3
regulation of vascular smooth muscle contraction -0.17 0.33 -10000 0 -0.97 2 2
PRKCQ -0.091 0.12 -10000 0 -0.28 3 3
PLA2G4A -0.16 0.22 -10000 0 -0.49 4 4
GNA14 -0.005 0.081 -10000 0 -0.31 1 1
GNA15 0.022 0.01 -10000 0 -10000 0 0
GNA12 0.019 0.011 -10000 0 -10000 0 0
GNA11 -0.005 0.069 -10000 0 -0.19 2 2
Rac1/GTP -0.038 0.14 -10000 0 -0.33 2 2
MMP1 0.018 0.081 -10000 0 -10000 0 0
IL23-mediated signaling events

Figure S7.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S7.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCL2 -0.3 0.55 -10000 0 -1.3 3 3
IL23A -0.3 0.55 -10000 0 -1.3 3 3
NF kappa B1 p50/RelA/I kappa B alpha -0.28 0.56 -10000 0 -1.1 4 4
positive regulation of T cell mediated cytotoxicity -0.34 0.64 -10000 0 -1.3 4 4
ITGA3 -0.28 0.52 -10000 0 -1.2 3 3
IL17F -0.18 0.34 -10000 0 -0.7 4 4
IL12B -0.019 0.095 -10000 0 -0.35 1 1
STAT1 (dimer) -0.32 0.61 -10000 0 -1.2 4 4
CD4 -0.28 0.51 -10000 0 -1.2 3 3
IL23 -0.31 0.52 -10000 0 -1.3 3 3
IL23R -0.15 0.4 -10000 0 -1.2 2 2
IL1B -0.34 0.61 -10000 0 -1.5 3 3
T-helper cell lineage commitment 0 0 -10000 0 -10000 0 0
IL24 -0.26 0.52 -10000 0 -1.2 3 3
TYK2 0.002 0.038 -10000 0 -10000 0 0
STAT4 -0.03 0.12 -10000 0 -0.27 3 3
STAT3 0.001 0.08 -10000 0 -0.31 1 1
IL18RAP -0.029 0.12 -10000 0 -0.26 3 3
IL12RB1 0.002 0.038 -10000 0 -10000 0 0
PIK3CA 0.025 0 -10000 0 -10000 0 0
IL12Rbeta1/TYK2 0.01 0.048 -10000 0 -10000 0 0
IL23R/JAK2 -0.13 0.36 -10000 0 -1.1 2 2
positive regulation of chronic inflammatory response -0.34 0.64 -10000 0 -1.3 4 4
natural killer cell activation 0.01 0.026 0.076 2 -10000 0 2
JAK2 0.003 0.041 -10000 0 -10000 0 0
PIK3R1 0.024 0.006 -10000 0 -10000 0 0
NFKB1 -0.001 0.08 -10000 0 -0.3 1 1
RELA 0.019 0.015 -10000 0 -10000 0 0
positive regulation of dendritic cell antigen processing and presentation -0.29 0.49 -10000 0 -1.2 3 3
ALOX12B -0.28 0.51 -10000 0 -1.2 3 3
CXCL1 -0.4 0.6 -10000 0 -1.1 6 6
T cell proliferation -0.34 0.64 -10000 0 -1.3 4 4
NFKBIA 0.018 0.016 -10000 0 -10000 0 0
IL17A -0.14 0.27 -10000 0 -0.53 4 4
PI3K -0.3 0.57 -10000 0 -1.2 4 4
IFNG 0 0.049 0.16 1 -10000 0 1
STAT3 (dimer) -0.28 0.54 -10000 0 -1.1 4 4
IL18R1 -0.009 0.093 -10000 0 -0.25 2 2
IL23/IL23R/JAK2/TYK2/SOCS3 -0.17 0.38 -10000 0 -0.84 3 3
IL18/IL18R -0.018 0.13 -10000 0 -0.32 2 2
macrophage activation -0.014 0.02 -10000 0 -0.046 2 2
TNF -0.3 0.55 -10000 0 -1.3 3 3
STAT3/STAT4 -0.32 0.58 -10000 0 -1.2 4 4
STAT4 (dimer) -0.34 0.61 -10000 0 -1.3 4 4
IL18 0.005 0.079 -10000 0 -0.3 1 1
IL19 -0.26 0.52 -10000 0 -1.2 3 3
STAT5A (dimer) -0.32 0.6 -10000 0 -1.2 4 4
STAT1 0.012 0.051 -10000 0 -0.19 1 1
SOCS3 0.001 0.08 -10000 0 -0.31 1 1
CXCL9 -0.31 0.55 -10000 0 -1.3 3 3
MPO -0.26 0.52 -10000 0 -1.2 3 3
positive regulation of humoral immune response -0.34 0.64 -10000 0 -1.3 4 4
IL23/IL23R/JAK2/TYK2 -0.38 0.76 -10000 0 -1.5 4 4
IL6 -0.26 0.57 -10000 0 -1.3 3 3
STAT5A 0.022 0.008 -10000 0 -10000 0 0
IL2 0.014 0.053 -10000 0 -0.19 1 1
positive regulation of tyrosine phosphorylation of STAT protein 0.01 0.026 0.076 2 -10000 0 2
CD3E -0.28 0.51 -10000 0 -1.2 3 3
keratinocyte proliferation -0.34 0.64 -10000 0 -1.3 4 4
NOS2 -0.28 0.51 -10000 0 -1.1 4 4
E-cadherin signaling events

Figure S8.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S8.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
E-cadherin/beta catenin-gamma catenin -0.006 0.074 -9999 0 -0.18 1 1
E-cadherin/beta catenin -0.035 0.1 -9999 0 -0.18 5 5
CTNNB1 -0.018 0.11 -9999 0 -0.31 2 2
JUP 0.009 0.051 -9999 0 -0.19 1 1
CDH1 -0.024 0.1 -9999 0 -0.23 3 3
Caspase cascade in apoptosis

Figure S9.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S9.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TOP1 -0.02 0.091 -10000 0 -0.25 1 1
ACTA1 -0.05 0.11 -10000 0 -0.23 3 3
NUMA1 -0.02 0.091 -10000 0 -0.25 1 1
SPTAN1 -0.053 0.12 -10000 0 -0.25 3 3
LIMK1 -0.005 0.14 0.18 3 -0.27 2 5
BIRC3 -0.051 0.13 -10000 0 -0.28 4 4
BIRC2 0.025 0 -10000 0 -10000 0 0
BAX 0.025 0 -10000 0 -10000 0 0
CASP10 -0.06 0.075 -10000 0 -0.18 4 4
CRMA 0 0 -10000 0 -10000 0 0
XIAP 0 0 -10000 0 -10000 0 0
PTK2 -0.02 0.091 -10000 0 -0.25 1 1
DIABLO 0.025 0 -10000 0 -10000 0 0
apoptotic nuclear changes -0.052 0.11 -10000 0 -0.25 3 3
response to UV 0 0 -10000 0 -10000 0 0
CRADD 0.004 0.081 -10000 0 -0.31 1 1
GSN -0.053 0.12 -10000 0 -0.25 3 3
MADD 0.023 0.006 -10000 0 -10000 0 0
TFAP2A 0.027 0.025 -10000 0 -10000 0 0
BID -0.047 0.066 -10000 0 -0.15 4 4
MAP3K1 -0.063 0.16 -10000 0 -0.45 2 2
TRADD 0.023 0.006 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.02 0.061 -10000 0 -0.21 1 1
mol:Activated DNA 0 0 -10000 0 -10000 0 0
ARHGDIB -0.054 0.11 -10000 0 -0.25 3 3
CASP9 0.024 0.006 -10000 0 -10000 0 0
DNA repair -0.007 0.066 0.15 1 -0.14 1 2
neuron apoptosis -0.051 0.18 -10000 0 -0.52 2 2
mol:NAD 0 0 -10000 0 -10000 0 0
DNA fragmentation during apoptosis -0.037 0.11 -10000 0 -0.29 1 1
APAF1 0.004 0.081 -10000 0 -0.31 1 1
CASP6 0.004 0.067 -10000 0 -10000 0 0
TRAF2 0.023 0.006 -10000 0 -10000 0 0
ICAD/CAD -0.053 0.11 -10000 0 -0.24 3 3
CASP7 0.039 0.11 0.22 3 -0.23 1 4
KRT18 0.016 0.022 -10000 0 -10000 0 0
apoptosis -0.038 0.097 -10000 0 -0.3 1 1
DFFA -0.053 0.11 -10000 0 -0.25 3 3
DFFB -0.053 0.11 -10000 0 -0.25 3 3
PARP1 0.007 0.066 0.14 1 -0.15 1 2
actin filament polymerization 0.01 0.14 0.29 2 -10000 0 2
TNF 0.012 0.051 -10000 0 -0.19 1 1
CYCS -0.016 0.045 -10000 0 -10000 0 0
SATB1 0.001 0.064 -10000 0 -10000 0 0
SLK -0.053 0.11 -10000 0 -0.25 3 3
p15 BID/BAX -0.044 0.068 -10000 0 -0.19 1 1
CASP2 0.011 0.14 0.2 4 -0.31 1 5
JNK cascade 0.062 0.16 0.45 2 -10000 0 2
CASP3 -0.053 0.12 -10000 0 -0.26 3 3
LMNB2 0.025 0.096 -10000 0 -10000 0 0
RIPK1 0.025 0 -10000 0 -10000 0 0
CASP4 0.025 0 -10000 0 -10000 0 0
Mammalian IAPs/DIABLO 0 0.085 -10000 0 -0.16 3 3
negative regulation of DNA binding 0.027 0.024 -10000 0 -10000 0 0
stress fiber formation -0.052 0.11 -10000 0 -0.24 3 3
GZMB -0.067 0.092 -10000 0 -0.22 4 4
CASP1 0.003 0.025 -10000 0 -10000 0 0
LMNB1 0.01 0.095 -10000 0 -10000 0 0
APP -0.052 0.18 -10000 0 -0.53 2 2
TNFRSF1A 0.025 0 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
CASP8 -0.002 0.005 -10000 0 -10000 0 0
VIM -0.033 0.1 -10000 0 -0.31 1 1
LMNA 0.024 0.096 -10000 0 -10000 0 0
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD -0.032 0.095 -10000 0 -0.32 1 1
LRDD 0.025 0 -10000 0 -10000 0 0
SREBF1 -0.053 0.11 -10000 0 -0.25 3 3
APAF-1/Caspase 9 -0.009 0.16 -10000 0 -0.57 1 1
nuclear fragmentation during apoptosis -0.02 0.091 -10000 0 -0.25 1 1
CFL2 -0.011 0.14 -10000 0 -0.29 2 2
GAS2 -0.057 0.13 -10000 0 -0.28 3 3
positive regulation of apoptosis 0.023 0.094 0.18 3 -10000 0 3
PRF1 -0.01 0.092 -10000 0 -0.25 2 2
PLK2 and PLK4 events

Figure S10.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S10.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLK2 -0.018 0.11 -9999 0 -0.31 2 2
PLK4 0.025 0 -9999 0 -10000 0 0
regulation of centriole replication -0.036 0.067 -9999 0 -0.21 2 2
Visual signal transduction: Cones

Figure S11.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S11.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Cone Metarhodopsin II/Cone Transducin -0.012 0.085 -9999 0 -0.15 4 4
RGS9BP -0.03 0.12 -9999 0 -0.27 3 3
mol:GTP 0 0 -9999 0 -10000 0 0
GRK1 0 0 -9999 0 -10000 0 0
mol:Na + 0.025 0.033 -9999 0 -0.1 1 1
mol:ADP -0.005 0 -9999 0 -10000 0 0
GNAT2 0.023 0.006 -9999 0 -10000 0 0
RGS9-1/Gbeta5/R9AP -0.047 0.1 -9999 0 -0.18 5 5
mol:GDP 0 0 -9999 0 -10000 0 0
PDE6H/GNAT2/GTP 0.019 0.051 -9999 0 -0.18 1 1
GRK7 0.025 0 -9999 0 -10000 0 0
CNGB3 0.009 0.052 -9999 0 -0.19 1 1
Cone Metarhodopsin II/X-Arrestin 0.019 0 -9999 0 -10000 0 0
mol:Ca2+ -0.009 0.047 -9999 0 -0.16 1 1
Cone PDE6 -0.047 0.11 -9999 0 -0.17 6 6
Cone Metarhodopsin II 0.016 0 -9999 0 -10000 0 0
Na + (4 Units) 0.019 0.059 -9999 0 -0.16 1 1
GNAT2/GDP -0.033 0.094 -9999 0 -0.15 5 5
GNB5 -0.017 0.11 -9999 0 -0.31 2 2
mol:GMP (4 units) -0.005 0.061 -9999 0 -0.24 1 1
Cone Transducin -0.012 0.092 -9999 0 -0.16 4 4
SLC24A2 0.001 0.08 -9999 0 -0.31 1 1
GNB3/GNGT2 -0.036 0.11 -9999 0 -0.2 5 5
GNB3 0.004 0.081 -9999 0 -0.31 1 1
GNAT2/GTP 0.017 0.004 -9999 0 -10000 0 0
CNGA3 0.025 0 -9999 0 -10000 0 0
ARR3 0.025 0 -9999 0 -10000 0 0
absorption of light 0 0 -9999 0 -10000 0 0
cGMP/Cone CNG Channel 0.025 0.033 -9999 0 -0.1 1 1
mol:Pi -0.047 0.1 -9999 0 -0.18 5 5
Cone CNG Channel 0.031 0.076 -9999 0 -0.22 1 1
mol:all-trans-retinal 0 0 -9999 0 -10000 0 0
mol:K + 0.001 0.08 -9999 0 -0.31 1 1
RGS9 -0.033 0.12 -9999 0 -0.27 3 3
PDE6C 0.01 0.051 -9999 0 -0.19 1 1
GNGT2 -0.051 0.13 -9999 0 -0.28 4 4
mol:cGMP (4 units) 0 0 -9999 0 -10000 0 0
PDE6H 0.004 0.081 -9999 0 -0.31 1 1
Osteopontin-mediated events

Figure S12.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S12.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer -0.066 0.12 -9999 0 -0.28 3 3
NF kappa B1 p50/RelA/I kappa B alpha -0.061 0.14 -9999 0 -0.31 3 3
alphaV/beta3 Integrin/Osteopontin/Src -0.027 0.11 -9999 0 -0.21 4 4
AP1 -0.096 0.12 -9999 0 -0.27 4 4
ILK -0.056 0.09 -9999 0 -0.23 1 1
bone resorption -0.076 0.1 -9999 0 -0.34 1 1
PTK2B 0.023 0.006 -9999 0 -10000 0 0
PYK2/p130Cas -0.043 0.11 -9999 0 -0.22 2 2
ITGAV 0.002 0.081 -9999 0 -0.3 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
CD44/Rho Family GTPase/ROCK2 0.009 0.07 -9999 0 -0.17 2 2
alphaV/beta3 Integrin/Osteopontin -0.038 0.12 -9999 0 -0.19 6 6
MAP3K1 -0.068 0.1 -9999 0 -0.23 3 3
JUN -0.003 0.069 -9999 0 -0.19 2 2
MAPK3 -0.066 0.11 -9999 0 -0.26 3 3
MAPK1 -0.074 0.11 -9999 0 -0.26 3 3
Rac1/GDP 0.014 0.008 -9999 0 -10000 0 0
NFKB1 0.004 0.081 -9999 0 -0.31 1 1
MAPK8 -0.08 0.1 -9999 0 -0.26 3 3
ITGB3 -0.022 0.1 -9999 0 -0.23 3 3
NFKBIA -0.075 0.13 -9999 0 -0.33 3 3
FOS -0.033 0.12 -9999 0 -0.27 3 3
CD44 -0.011 0.092 -9999 0 -0.25 2 2
CHUK 0.003 0.081 -9999 0 -0.31 1 1
PLAU -0.12 0.25 -9999 0 -0.68 2 2
NF kappa B1 p50/RelA -0.055 0.14 -9999 0 -0.32 3 3
BCAR1 0.023 0.006 -9999 0 -10000 0 0
RELA 0.025 0 -9999 0 -10000 0 0
alphaV beta3 Integrin -0.01 0.11 -9999 0 -0.23 3 3
mol:GDP 0 0 -9999 0 -10000 0 0
SYK -0.075 0.096 -9999 0 -0.24 2 2
VAV3 -0.081 0.082 -9999 0 -0.22 2 2
MAP3K14 -0.067 0.11 -9999 0 -0.25 3 3
ROCK2 0.025 0 -9999 0 -10000 0 0
SPP1 -0.039 0.13 -9999 0 -0.3 3 3
RAC1 0.019 0.011 -9999 0 -10000 0 0
Rac1/GTP -0.06 0.082 -9999 0 -0.21 2 2
MMP2 -0.086 0.089 -9999 0 -0.29 1 1
Lissencephaly gene (LIS1) in neuronal migration and development

Figure S13.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S13.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
DYNC1H1 0.022 0.008 -10000 0 -10000 0 0
VLDLR -0.018 0.11 -10000 0 -0.31 2 2
LRPAP1 0.025 0 -10000 0 -10000 0 0
NUDC 0.025 0 -10000 0 -10000 0 0
RELN/LRP8 -0.012 0.084 -10000 0 -0.18 3 3
CaM/Ca2+ 0.016 0.006 -10000 0 -10000 0 0
KATNA1 0.025 0 -10000 0 -10000 0 0
GO:0030286 0 0 -10000 0 -10000 0 0
ABL1 0.024 0.12 0.18 5 -0.16 3 8
IQGAP1/CaM 0.033 0.012 -10000 0 -10000 0 0
DAB1 0.023 0.006 -10000 0 -10000 0 0
IQGAP1 0.025 0 -10000 0 -10000 0 0
PLA2G7 -0.077 0.14 -10000 0 -0.25 6 6
CALM1 0.022 0.008 -10000 0 -10000 0 0
DYNLT1 -0.009 0.093 -10000 0 -0.25 2 2
mol:Ca2+ 0 0 -10000 0 -10000 0 0
LRPAP1/LRP8 0.025 0.04 -10000 0 -0.13 1 1
UniProt:Q4QZ09 0 0 -10000 0 -10000 0 0
CLIP1 0 0 -10000 0 -10000 0 0
CDK5R1 0.025 0 -10000 0 -10000 0 0
LIS1/Poliovirus Protein 3A -0.008 0.002 -10000 0 -10000 0 0
CDK5R2 0.025 0 -10000 0 -10000 0 0
mol:PP1 0 0 -10000 0 -10000 0 0
RELN/VLDLR/DAB1 -0.036 0.11 -10000 0 -0.22 4 4
YWHAE 0.022 0.008 -10000 0 -10000 0 0
NDEL1/14-3-3 E 0.073 0.15 0.31 4 -10000 0 4
MAP1B 0.005 0.001 -10000 0 -10000 0 0
RAC1 0.008 0.005 -10000 0 -10000 0 0
p35/CDK5 -0.019 0.081 0.17 1 -10000 0 1
RELN -0.045 0.13 -10000 0 -0.31 3 3
PAFAH/LIS1 -0.039 0.084 -10000 0 -0.18 3 3
LIS1/CLIP170 -0.008 0.002 -10000 0 -10000 0 0
LIS1/NDEL1/Katanin 60/Dynein Light chain/Dynein heavy chain -0.021 0.058 -10000 0 -10000 0 0
RELN/VLDLR/DAB1/LIS1/PAFAH1B2/PAFAH1B3 -0.048 0.11 -10000 0 -0.29 2 2
GO:0005869 0 0 -10000 0 -10000 0 0
NDEL1 0.055 0.16 0.31 4 -10000 0 4
LIS1/IQGAP1 0.025 0.006 -10000 0 -10000 0 0
RHOA -0.01 0.082 -10000 0 -0.33 1 1
PAFAH1B1 -0.01 0.003 -10000 0 -10000 0 0
PAFAH1B3 0.025 0 -10000 0 -10000 0 0
PAFAH1B2 0.025 0 -10000 0 -10000 0 0
MAP1B/LIS1/Dynein heavy chain 0.023 0.009 -10000 0 -10000 0 0
NDEL1/Katanin 60/Dynein heavy chain 0.062 0.15 0.31 4 -10000 0 4
LRP8 0.01 0.051 -10000 0 -0.19 1 1
NDEL1/Katanin 60 0.064 0.16 0.31 4 -10000 0 4
P39/CDK5 -0.019 0.081 0.17 1 -10000 0 1
LIS1/NudC/Dynein intermediate chain/microtubule organizing center 0.025 0.006 -10000 0 -10000 0 0
CDK5 -0.019 0.082 0.17 1 -10000 0 1
PPP2R5D 0.025 0 -10000 0 -10000 0 0
LIS1/CLIP170/Dynein Complex/Dynactin Complex -0.006 0.002 -10000 0 -10000 0 0
CSNK2A1 0.025 0 -10000 0 -10000 0 0
RELN/VLDLR/DAB1/LIS1 -0.027 0.1 -10000 0 -0.19 4 4
RELN/VLDLR -0.026 0.11 -10000 0 -0.2 4 4
CDC42 0.011 0.003 -10000 0 -10000 0 0
Signaling events mediated by the Hedgehog family

Figure S14.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S14.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB2 0.009 0.038 -10000 0 -10000 0 0
IHH -0.008 0.081 -10000 0 -0.17 3 3
SHH Np/Cholesterol/GAS1 -0.004 0.05 -10000 0 -0.16 1 1
LRPAP1 0.025 0 -10000 0 -10000 0 0
dorsoventral neural tube patterning 0.004 0.049 0.16 1 -10000 0 1
SMO/beta Arrestin2 0.015 0.083 -10000 0 -0.27 1 1
SMO -0.009 0.071 -10000 0 -0.28 1 1
AKT1 0.011 0.037 -10000 0 -10000 0 0
ARRB2 0.023 0.006 -10000 0 -10000 0 0
BOC -0.035 0.11 -10000 0 -0.22 4 4
ADRBK1 0.025 0 -10000 0 -10000 0 0
heart looping -0.009 0.07 -10000 0 -0.27 1 1
STIL 0.034 0.087 0.18 3 -10000 0 3
DHH N/PTCH2 0.019 0.061 -10000 0 -0.21 1 1
DHH N/PTCH1 0.015 0.035 -10000 0 -10000 0 0
PIK3CA 0.025 0 -10000 0 -10000 0 0
DHH 0.025 0 -10000 0 -10000 0 0
PTHLH 0.009 0.04 -10000 0 -10000 0 0
determination of left/right symmetry -0.009 0.07 -10000 0 -0.27 1 1
PIK3R1 0.023 0.006 -10000 0 -10000 0 0
skeletal system development 0.009 0.04 -10000 0 -10000 0 0
IHH N/Hhip -0.018 0.077 -10000 0 -0.14 3 3
DHH N/Hhip 0.007 0.064 -10000 0 -0.13 3 3
mol:Cholesterol 0 0 -10000 0 -10000 0 0
heart development -0.009 0.07 -10000 0 -0.27 1 1
pancreas development -0.015 0.082 -10000 0 -0.19 3 3
HHAT 0.023 0.006 -10000 0 -10000 0 0
PI3K 0.035 0.009 -10000 0 -10000 0 0
EntrezGene:84976 0 0 -10000 0 -10000 0 0
GAS1 -0.031 0.12 -10000 0 -0.27 3 3
somite specification -0.009 0.07 -10000 0 -0.27 1 1
SHH Np/Cholesterol/PTCH1 -0.006 0.04 -10000 0 -10000 0 0
SHH Np/Cholesterol/PTCH2 -0.007 0.06 -10000 0 -0.16 2 2
SHH Np/Cholesterol/Megalin -0.026 0.071 -10000 0 -0.16 3 3
SHH -0.02 0.05 -10000 0 -0.21 1 1
catabolic process 0.004 0.03 -10000 0 -10000 0 0
SMO/Vitamin D3 0 0.071 0.19 1 -10000 0 1
SHH Np/Cholesterol/Hhip -0.001 0.072 -10000 0 -0.24 1 1
LRP2 -0.051 0.13 -10000 0 -0.28 4 4
receptor-mediated endocytosis -0.025 0.078 -10000 0 -0.27 1 1
SHH Np/Cholesterol/BOC -0.012 0.088 -10000 0 -0.3 1 1
SHH Np/Cholesterol/CDO -0.003 0.05 -10000 0 -0.16 1 1
mesenchymal cell differentiation 0.001 0.071 0.24 1 -10000 0 1
mol:Vitamin D3 0.05 0.098 0.18 5 -10000 0 5
IHH N/PTCH2 0 0.09 -10000 0 -0.3 1 1
CDON 0.012 0.051 -10000 0 -0.19 1 1
IHH N/PTCH1 0.016 0.038 -10000 0 -10000 0 0
Megalin/LRPAP1 -0.02 0.1 -10000 0 -0.19 4 4
PTCH2 0.003 0.081 -10000 0 -0.31 1 1
SHH Np/Cholesterol -0.001 0.041 -10000 0 -0.16 1 1
PTCH1 0.004 0.03 -10000 0 -10000 0 0
HHIP -0.015 0.082 -10000 0 -0.19 3 3
Ephrin A reverse signaling

Figure S15.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S15.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAPKKK cascade 0.015 0.045 -10000 0 -0.1 2 2
EFNA5 -0.003 0.07 -10000 0 -0.19 2 2
FYN -0.003 0.071 0.18 1 -0.17 1 2
neuron projection morphogenesis 0.015 0.045 -10000 0 -0.1 2 2
cell-cell signaling 0 0 -10000 0 -10000 0 0
Ephrin A5/EPHA5 0.015 0.045 -10000 0 -0.1 2 2
EPHA5 0.025 0 -10000 0 -10000 0 0
Thromboxane A2 receptor signaling

Figure S16.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S16.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGM2 -0.017 0.11 -9999 0 -0.31 2 2
GNB1/GNG2 -0.054 0.074 -9999 0 -0.18 4 4
AKT1 -0.058 0.12 -9999 0 -0.23 3 3
EGF -0.056 0.12 -9999 0 -0.24 5 5
mol:TXA2 0 0.001 -9999 0 -10000 0 0
FGR -0.021 0.018 -9999 0 -10000 0 0
mol:Ca2+ -0.064 0.14 -9999 0 -0.26 4 4
LYN -0.021 0.018 -9999 0 -10000 0 0
RhoA/GTP -0.03 0.054 -9999 0 -0.12 1 1
mol:PGI2 0 0 -9999 0 -10000 0 0
SYK -0.092 0.15 -9999 0 -0.32 4 4
GNG2 0.022 0.008 -9999 0 -10000 0 0
ARRB2 0.023 0.006 -9999 0 -10000 0 0
TP alpha/Gq family/GDP/G beta5/gamma2 -0.04 0.097 -9999 0 -0.28 2 2
G beta5/gamma2 -0.06 0.1 -9999 0 -0.23 4 4
PRKCH -0.087 0.16 -9999 0 -0.32 4 4
DNM1 -0.011 0.092 -9999 0 -0.25 2 2
TXA2/TP beta/beta Arrestin3 0 0.041 -9999 0 -10000 0 0
mol:GTP 0 0.001 -9999 0 -10000 0 0
PTGDR 0.009 0.051 -9999 0 -0.19 1 1
G12 family/GTP -0.059 0.11 -9999 0 -0.26 2 2
ADRBK1 0.025 0 -9999 0 -10000 0 0
ADRBK2 0.025 0 -9999 0 -10000 0 0
RhoA/GTP/ROCK1 0.018 0.051 -9999 0 -0.18 1 1
mol:GDP 0.029 0.083 -9999 0 -10000 0 0
mol:NADP 0.019 0.011 -9999 0 -10000 0 0
RAB11A 0.025 0 -9999 0 -10000 0 0
PRKG1 0.023 0.006 -9999 0 -10000 0 0
mol:IP3 -0.082 0.17 -9999 0 -0.32 4 4
cell morphogenesis 0.018 0.051 -9999 0 -0.18 1 1
PLCB2 -0.11 0.22 -9999 0 -0.43 4 4
mol:cGMP 0 0.001 -9999 0 -10000 0 0
BLK -0.027 0.035 -9999 0 -10000 0 0
mol:PDG2 0 0 -9999 0 -10000 0 0
HCK -0.047 0.047 -9999 0 -10000 0 0
RHOA 0.004 0.081 -9999 0 -0.31 1 1
PTGIR 0.025 0 -9999 0 -10000 0 0
PRKCB1 -0.07 0.17 -9999 0 -0.36 3 3
GNAQ 0 0 -9999 0 -10000 0 0
mol:L-citrulline 0.019 0.011 -9999 0 -10000 0 0
TXA2/TXA2-R family -0.12 0.22 -9999 0 -0.46 4 4
LCK -0.021 0.02 -9999 0 -10000 0 0
TXA2/TP beta/beta Arrestin3/RAB11/GDP 0.015 0.035 -9999 0 -10000 0 0
TXA2-R family/G12 family/GDP/G beta/gamma -0.005 0.096 -9999 0 -0.36 1 1
TXA2/TP beta/beta Arrestin2/RAB11/GDP 0.016 0.033 -9999 0 -10000 0 0
MAPK14 -0.063 0.1 -9999 0 -0.21 4 4
TGM2/GTP -0.093 0.2 -9999 0 -0.38 3 3
MAPK11 -0.068 0.11 -9999 0 -0.21 5 5
ARHGEF1 -0.036 0.07 -9999 0 -0.16 2 2
GNAI2 0.025 0 -9999 0 -10000 0 0
JNK cascade -0.085 0.17 -9999 0 -0.34 4 4
RAB11/GDP 0.025 0.001 -9999 0 -10000 0 0
ICAM1 -0.058 0.13 -9999 0 -0.25 4 4
cAMP biosynthetic process -0.081 0.16 -9999 0 -0.31 3 3
Gq family/GTP/EBP50 -0.016 0.056 -9999 0 -0.16 2 2
actin cytoskeleton reorganization 0.018 0.051 -9999 0 -0.18 1 1
SRC -0.021 0.018 -9999 0 -10000 0 0
GNB5 -0.017 0.11 -9999 0 -0.31 2 2
GNB1 0.023 0.006 -9999 0 -10000 0 0
EGF/EGFR -0.049 0.069 -9999 0 -0.2 1 1
VCAM1 -0.078 0.16 -9999 0 -0.32 4 4
TP beta/Gq family/GDP/G beta5/gamma2 -0.04 0.097 -9999 0 -0.28 2 2
platelet activation -0.081 0.13 -9999 0 -0.27 4 4
PGI2/IP 0.018 0.001 -9999 0 -10000 0 0
PRKACA 0.009 0.017 -9999 0 -10000 0 0
Gq family/GDP/G beta5/gamma2 -0.038 0.09 -9999 0 -0.26 2 2
TXA2/TP beta/beta Arrestin2 -0.05 0.12 -9999 0 -0.34 2 2
positive regulation of NF-kappaB transcription factor activity 0 0 -9999 0 -10000 0 0
TBXA2R -0.004 0.021 -9999 0 -10000 0 0
mol:DAG -0.091 0.18 -9999 0 -0.36 4 4
EGFR -0.036 0.12 -9999 0 -0.27 3 3
TXA2/TP alpha -0.11 0.21 -9999 0 -0.45 2 2
Gq family/GTP -0.011 0.046 -9999 0 -0.18 1 1
YES1 -0.02 0.024 -9999 0 -10000 0 0
GNAI2/GTP 0 0.034 -9999 0 -10000 0 0
PGD2/DP 0.007 0.034 -9999 0 -0.12 1 1
SLC9A3R1 0.001 0.08 -9999 0 -0.31 1 1
FYN -0.029 0.028 -9999 0 -10000 0 0
mol:NO 0.019 0.011 -9999 0 -10000 0 0
GNA15 0.025 0 -9999 0 -10000 0 0
PGK/cGMP 0.023 0.016 -9999 0 -10000 0 0
RhoA/GDP 0.005 0.08 -9999 0 -0.3 1 1
TP alpha/TGM2/GDP/G beta/gamma 0.008 0.066 -9999 0 -10000 0 0
NOS3 0.019 0.011 -9999 0 -10000 0 0
RAC1 0.019 0.011 -9999 0 -10000 0 0
PRKCA -0.064 0.14 -9999 0 -0.3 2 2
PRKCB -0.079 0.16 -9999 0 -0.32 4 4
PRKCE -0.072 0.16 -9999 0 -0.31 4 4
PRKCD -0.087 0.17 -9999 0 -0.35 4 4
PRKCG -0.091 0.18 -9999 0 -0.36 4 4
muscle contraction -0.11 0.2 -9999 0 -0.42 4 4
PRKCZ -0.075 0.15 -9999 0 -0.3 4 4
ARR3 0.025 0 -9999 0 -10000 0 0
TXA2/TP beta 0.016 0.036 -9999 0 -10000 0 0
PRKCQ -0.087 0.16 -9999 0 -0.32 4 4
MAPKKK cascade -0.099 0.19 -9999 0 -0.38 4 4
SELE -0.067 0.14 -9999 0 -0.29 4 4
TP beta/GNAI2/GDP/G beta/gamma 0.032 0.038 -9999 0 -10000 0 0
ROCK1 0.023 0.006 -9999 0 -10000 0 0
GNA14 0.003 0.081 -9999 0 -0.31 1 1
chemotaxis -0.14 0.26 -9999 0 -0.55 4 4
GNA12 0.019 0.011 -9999 0 -10000 0 0
GNA13 0.022 0.008 -9999 0 -10000 0 0
GNA11 -0.001 0.07 -9999 0 -0.19 2 2
Rac1/GTP 0.014 0.008 -9999 0 -10000 0 0
a4b1 and a4b7 Integrin signaling

Figure S17.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S17.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ITGB1 0.023 0.006 -9999 0 -10000 0 0
ITGB7 0.012 0.051 -9999 0 -0.19 1 1
ITGA4 -0.009 0.093 -9999 0 -0.25 2 2
alpha4/beta7 Integrin 0.001 0.077 -9999 0 -0.16 3 3
alpha4/beta1 Integrin 0.009 0.07 -9999 0 -0.17 2 2
Arf6 signaling events

Figure S18.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S18.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CENTA1/KIF3B 0.016 0.004 -10000 0 -10000 0 0
ARNO/beta Arrestin1-2 0.008 0.05 -10000 0 -0.13 1 1
EGFR -0.036 0.12 -10000 0 -0.27 3 3
EPHA2 0.023 0.006 -10000 0 -10000 0 0
USP6 0.023 0.006 -10000 0 -10000 0 0
IQSEC1 0.025 0 -10000 0 -10000 0 0
EGFR/EGFR/EGF/EGF -0.067 0.13 -10000 0 -0.22 6 6
ARRB2 0.011 0.003 -10000 0 -10000 0 0
mol:GTP 0.002 0.007 -10000 0 -10000 0 0
ARRB1 0.025 0 -10000 0 -10000 0 0
FBXO8 0.023 0.006 -10000 0 -10000 0 0
TSHR 0.022 0.008 -10000 0 -10000 0 0
EGF -0.056 0.12 -10000 0 -0.24 5 5
somatostatin receptor activity 0 0 0 4 0 2 6
ARAP2 0 0 0 3 0 2 5
mol:GDP 0.015 0.079 0.14 3 -10000 0 3
mol:PI-3-4-5-P3 0 0 0 3 0 2 5
ITGA2B 0.024 0.006 -10000 0 -10000 0 0
ARF6 0.022 0.008 -10000 0 -10000 0 0
Ephrin A1/EPHA2/NCK1/GIT1 0.046 0.057 -10000 0 -0.16 1 1
ADAP1 0 0 -10000 0 -10000 0 0
KIF13B 0.023 0.006 -10000 0 -10000 0 0
HGF/MET 0.023 0.018 -10000 0 -10000 0 0
PXN 0.025 0 -10000 0 -10000 0 0
ARF6/GTP -0.001 0.11 0.17 3 -0.16 2 5
EGFR/EGFR/EGF/EGF/ARFGEP100 -0.05 0.12 -10000 0 -0.26 3 3
ADRB2 -0.024 0.1 -10000 0 -0.23 3 3
receptor agonist activity 0 0 0 4 0 1 5
actin filament binding 0 0 0 4 0 2 6
SRC 0.025 0 -10000 0 -10000 0 0
ITGB3 -0.022 0.1 -10000 0 -0.23 3 3
GNAQ 0 0 0.001 4 -10000 0 4
EFA6/PI-4-5-P2 0 0.001 0.001 4 -10000 0 4
ARF6/GDP -0.014 0.094 -10000 0 -0.23 2 2
ARF6/GDP/GULP/ACAP1 0.008 0.095 -10000 0 -0.18 1 1
alphaIIb/beta3 Integrin/paxillin/GIT1 0.026 0.073 -10000 0 -0.16 1 1
ACAP1 0 0 -10000 0 -10000 0 0
ACAP2 0 0 0 3 0 2 5
LHCGR/beta Arrestin2 0.019 0.019 -10000 0 -10000 0 0
EFNA1 0.003 0.081 -10000 0 -0.31 1 1
HGF 0.019 0.011 -10000 0 -10000 0 0
CYTH3 0 0 0 4 0 1 5
CYTH2 -0.001 0.001 -10000 0 -0.003 2 2
NCK1 0.025 0 -10000 0 -10000 0 0
fibronectin binding 0 0 0 3 0 1 4
endosomal lumen acidification 0 0 0 3 0 1 4
microtubule-based process 0 0 -10000 0 -10000 0 0
GULP1 -0.03 0.12 -10000 0 -0.27 3 3
GNAQ/ARNO 0.001 0.004 0.007 4 -10000 0 4
mol:Phosphatidic acid 0 0 0 3 0 2 5
PIP3-E -0.02 0.081 -10000 0 -0.19 3 3
MET 0.016 0.012 -10000 0 -10000 0 0
GNA14 0.003 0.081 -10000 0 -0.31 1 1
GNA15 0.025 0 -10000 0 -10000 0 0
GIT1 0.025 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 0.001 4 0 1 5
GNA11 -0.001 0.07 -10000 0 -0.19 2 2
LHCGR 0.025 0 -10000 0 -10000 0 0
AGTR1 0.012 0.051 -10000 0 -0.19 1 1
desensitization of G-protein coupled receptor protein signaling pathway 0.019 0.019 -10000 0 -10000 0 0
IPCEF1/ARNO -0.048 0.099 -10000 0 -0.22 3 3
alphaIIb/beta3 Integrin -0.001 0.077 -10000 0 -0.16 3 3
Signaling events mediated by PTP1B

Figure S19.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S19.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.023 0.006 -10000 0 -10000 0 0
Jak2/Leptin Receptor -0.02 0.11 -10000 0 -0.26 1 1
PTP1B/AKT1 -0.051 0.13 -10000 0 -0.25 4 4
FYN -0.001 0.07 -10000 0 -0.19 2 2
p210 bcr-abl/PTP1B -0.049 0.14 0.17 1 -0.27 4 5
EGFR -0.041 0.12 -10000 0 -0.28 3 3
EGF/EGFR -0.089 0.18 -10000 0 -0.36 4 4
CSF1 0.023 0.006 -10000 0 -10000 0 0
AKT1 0.021 0.008 -10000 0 -10000 0 0
INSR 0.024 0.002 -10000 0 -10000 0 0
PTP1B/N-cadherin -0.05 0.16 0.17 1 -0.29 4 5
Insulin Receptor/Insulin -0.045 0.12 -10000 0 -0.25 2 2
HCK -0.056 0.12 -10000 0 -0.24 5 5
CRK 0.022 0.008 -10000 0 -10000 0 0
TYK2 -0.05 0.14 -10000 0 -0.26 4 4
EGF -0.057 0.13 -10000 0 -0.24 5 5
YES1 0.009 0.051 -10000 0 -0.19 1 1
CAV1 -0.029 0.17 0.16 3 -0.32 3 6
TXN 0.024 0.007 -10000 0 -10000 0 0
PTP1B/IRS1/GRB2 -0.042 0.12 -10000 0 -0.23 4 4
cell migration 0.049 0.14 0.27 4 -0.17 1 5
STAT3 0.001 0.081 -10000 0 -0.31 1 1
PRLR 0.016 0.052 -10000 0 -0.18 1 1
ITGA2B 0.023 0.006 -10000 0 -10000 0 0
CSF1R -0.018 0.11 -10000 0 -0.31 2 2
Prolactin Receptor/Prolactin 0.037 0.042 -10000 0 -10000 0 0
FGR 0.025 0 -10000 0 -10000 0 0
PTP1B/p130 Cas -0.035 0.14 0.17 1 -0.26 4 5
Crk/p130 Cas -0.027 0.12 -10000 0 -0.25 3 3
DOK1 -0.039 0.13 0.22 1 -0.25 3 4
JAK2 -0.015 0.12 -10000 0 -0.28 1 1
Jak2/Leptin Receptor/Leptin -0.074 0.09 -10000 0 -0.23 1 1
PIK3R1 0.023 0.006 -10000 0 -10000 0 0
PTPN1 -0.049 0.14 0.17 1 -0.27 4 5
LYN 0.025 0 -10000 0 -10000 0 0
CDH2 0.003 0.081 -10000 0 -0.31 1 1
SRC 0.007 0.056 -10000 0 -10000 0 0
ITGB3 -0.022 0.1 -10000 0 -0.23 3 3
CAT1/PTP1B -0.064 0.14 -10000 0 -0.37 1 1
CAPN1 0.003 0.082 -10000 0 -0.32 1 1
CSK 0.025 0 -10000 0 -10000 0 0
PI3K -0.038 0.12 -10000 0 -0.24 2 2
mol:H2O2 0 0.004 -10000 0 -10000 0 0
STAT3 (dimer) -0.067 0.091 -10000 0 -0.22 2 2
negative regulation of transcription -0.015 0.11 -10000 0 -0.27 1 1
FCGR2A -0.065 0.14 -10000 0 -0.26 5 5
FER 0.023 0.007 -10000 0 -10000 0 0
alphaIIb/beta3 Integrin -0.002 0.078 -10000 0 -0.16 3 3
BLK -0.012 0.092 -10000 0 -0.25 2 2
Insulin Receptor/Insulin/Shc 0.032 0.056 -10000 0 -0.18 1 1
RHOA 0.003 0.082 -10000 0 -0.32 1 1
LEPR 0.024 0.007 -10000 0 -10000 0 0
BCAR1 0.023 0.006 -10000 0 -10000 0 0
p210 bcr-abl/Grb2 0.022 0.008 -10000 0 -10000 0 0
mol:NADPH 0 0.004 -10000 0 -10000 0 0
TRPV6 -0.037 0.12 -10000 0 -0.23 1 1
PRL 0.029 0.004 -10000 0 -10000 0 0
SOCS3 -0.051 0.26 -10000 0 -1.1 1 1
SPRY2 0.013 0.052 -10000 0 -0.19 1 1
Insulin Receptor/Insulin/IRS1 0.021 0.065 -10000 0 -0.18 1 1
CSF1/CSF1R -0.061 0.15 -10000 0 -0.28 4 4
Ras protein signal transduction 0.078 0.21 0.59 2 -10000 0 2
IRS1 0.01 0.051 -10000 0 -0.19 1 1
INS 0.003 0.081 -10000 0 -0.31 1 1
LEP 0.017 0.012 -10000 0 -10000 0 0
STAT5B -0.029 0.12 0.17 1 -0.21 3 4
STAT5A -0.029 0.12 0.17 1 -0.21 3 4
GRB2 0.022 0.008 -10000 0 -10000 0 0
PDGFB-D/PDGFRB -0.051 0.13 -10000 0 -0.26 4 4
CSN2 0.022 0.027 -10000 0 -10000 0 0
PIK3CA 0.025 0 -10000 0 -10000 0 0
LAT -0.074 0.2 -10000 0 -0.44 3 3
YBX1 0.029 0.008 -10000 0 -10000 0 0
LCK 0.008 0.051 -10000 0 -0.19 1 1
SHC1 0.023 0.006 -10000 0 -10000 0 0
NOX4 -0.086 0.15 -10000 0 -0.27 6 6
IL4-mediated signaling events

Figure S20.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S20.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.22 0.43 -10000 0 -1.1 2 2
STAT6 (cleaved dimer) -0.21 0.41 -10000 0 -1.1 2 2
IGHG1 -0.062 0.16 -10000 0 -10000 0 0
IGHG3 -0.22 0.42 -10000 0 -0.93 3 3
AKT1 -0.1 0.27 -10000 0 -0.81 1 1
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 -0.085 0.28 -10000 0 -1 1 1
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 -0.099 0.25 -10000 0 -0.7 1 1
THY1 -0.23 0.44 -10000 0 -1.1 2 2
MYB 0.012 0.051 -10000 0 -0.19 1 1
HMGA1 0.025 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3 -0.11 0.26 -10000 0 -0.54 2 2
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP -0.094 0.25 -10000 0 -0.71 1 1
SP1 0.023 0.029 -10000 0 -10000 0 0
INPP5D 0 0 -10000 0 -10000 0 0
SOCS5 0.023 0.027 -10000 0 -10000 0 0
STAT6 (dimer)/ETS1 -0.23 0.43 -10000 0 -1.1 2 2
SOCS1 -0.16 0.32 -10000 0 -0.8 2 2
SOCS3 -0.12 0.35 -10000 0 -1.1 1 1
FCER2 -0.21 0.44 -10000 0 -1.1 2 2
PARP14 0.023 0.012 -10000 0 -10000 0 0
CCL17 -0.28 0.54 -10000 0 -1.5 2 2
GRB2 0.022 0.008 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP -0.079 0.22 -10000 0 -0.64 1 1
T cell proliferation -0.21 0.44 -10000 0 -0.96 3 3
IL4R/JAK1 -0.2 0.43 -10000 0 -1 2 2
EGR2 -0.29 0.52 -10000 0 -1.4 2 2
JAK2 0.003 0.047 -10000 0 -10000 0 0
JAK3 0.02 0.021 -10000 0 -10000 0 0
PIK3R1 0.023 0.006 -10000 0 -10000 0 0
JAK1 0.014 0.028 -10000 0 -10000 0 0
COL1A2 -0.1 0.34 -10000 0 -1.3 1 1
CCL26 -0.18 0.46 -10000 0 -1.1 2 2
IL4R -0.22 0.46 -10000 0 -1.1 2 2
PTPN6 0.005 0.079 -10000 0 -0.29 1 1
IL13RA2 -0.23 0.43 -10000 0 -1.1 2 2
IL13RA1 -0.02 0.091 -10000 0 -0.31 1 1
IRF4 -0.01 0.1 -10000 0 -10000 0 0
ARG1 -0.067 0.14 -10000 0 -10000 0 0
CBL -0.11 0.25 -10000 0 -0.52 2 2
GTF3A 0.014 0.035 -10000 0 -10000 0 0
PIK3CA 0.025 0 -10000 0 -10000 0 0
IL13RA1/JAK2 -0.008 0.076 -10000 0 -0.18 1 1
IRF4/BCL6 0 0.094 -10000 0 -10000 0 0
CD40LG 0.028 0.012 -10000 0 -10000 0 0
MAPK14 -0.12 0.27 -10000 0 -0.59 2 2
mitosis -0.089 0.26 -10000 0 -0.76 1 1
STAT6 -0.24 0.49 -10000 0 -1.2 2 2
SPI1 0.002 0.054 -10000 0 -0.18 1 1
RPS6KB1 -0.079 0.26 -10000 0 -0.74 1 1
STAT6 (dimer) -0.24 0.49 -10000 0 -1.2 2 2
STAT6 (dimer)/PARP14 -0.23 0.46 -10000 0 -1.1 2 2
mast cell activation 0.005 0.015 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 -0.083 0.23 -10000 0 -0.61 1 1
FRAP1 -0.095 0.27 -10000 0 -0.81 1 1
LTA -0.22 0.43 -10000 0 -1.1 2 2
FES 0.025 0 -10000 0 -10000 0 0
T-helper 1 cell differentiation 0.24 0.48 1.2 2 -10000 0 2
CCL11 -0.22 0.42 -10000 0 -1 2 2
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES -0.082 0.23 -10000 0 -0.61 1 1
IL2RG 0.02 0.021 -10000 0 -10000 0 0
IL10 -0.22 0.44 -10000 0 -1.1 2 2
IRS1 0.01 0.051 -10000 0 -0.19 1 1
IRS2 0.025 0 -10000 0 -10000 0 0
IL4 -0.085 0.31 -10000 0 -1.2 1 1
IL5 -0.22 0.44 -10000 0 -1.1 2 2
IL4/IL4R/JAK1/IL13RA1/JAK2 -0.17 0.36 -10000 0 -0.79 3 3
COL1A1 -0.12 0.35 -10000 0 -1.4 1 1
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1 -0.23 0.48 -10000 0 -1.2 2 2
IL2R gamma/JAK3 0.036 0.021 -10000 0 -10000 0 0
TFF3 -0.23 0.44 -10000 0 -1.1 2 2
ALOX15 -0.26 0.5 -10000 0 -1.2 3 3
MYBL1 0.012 0.051 -10000 0 -0.19 1 1
T-helper 2 cell differentiation -0.17 0.36 -10000 0 -0.78 3 3
SHC1 0.023 0.006 -10000 0 -10000 0 0
CEBPB 0.017 0.027 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 -0.084 0.23 -10000 0 -0.62 1 1
mol:PI-3-4-5-P3 -0.098 0.27 -10000 0 -0.81 1 1
PI3K -0.1 0.28 -10000 0 -0.87 1 1
DOK2 0.01 0.051 -10000 0 -0.19 1 1
ETS1 0.02 0.025 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 -0.053 0.21 -10000 0 -0.55 1 1
ITGB3 -0.27 0.51 -10000 0 -1.4 2 2
PIGR -0.29 0.52 -10000 0 -1.1 3 3
IGHE 0.013 0.039 -10000 0 -10000 0 0
MAPKKK cascade -0.052 0.21 -10000 0 -0.54 1 1
BCL6 0.025 0.004 -10000 0 -10000 0 0
OPRM1 -0.23 0.43 -10000 0 -1.1 2 2
RETNLB -0.26 0.5 -10000 0 -1.4 2 2
SELP -0.26 0.5 -10000 0 -1.2 3 3
AICDA -0.26 0.48 -10000 0 -1.3 2 2
Glypican 1 network

Figure S21.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S21.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GPC1/FGF2 dimer/FGFR1 dimer -0.001 0.085 -10000 0 -0.18 2 2
fibroblast growth factor receptor signaling pathway -0.001 0.085 -10000 0 -0.18 2 2
LAMA1 0.022 0.008 -10000 0 -10000 0 0
PRNP 0.025 0 -10000 0 -10000 0 0
GPC1/SLIT2 -0.076 0.12 -10000 0 -0.22 7 7
SMAD2 -0.032 0.045 -10000 0 -10000 0 0
GPC1/PrPc/Cu2+ 0.023 0.033 -10000 0 -0.1 1 1
GPC1/Laminin alpha1 0.02 0.04 -10000 0 -0.13 1 1
TDGF1 -0.015 0.082 -10000 0 -0.19 3 3
CRIPTO/GPC1 -0.006 0.07 -10000 0 -0.13 4 4
APP/GPC1 0.01 0.053 -10000 0 -0.13 2 2
mol:NO 0 0 -10000 0 -10000 0 0
YES1 -0.04 0.045 -10000 0 -10000 0 0
FLT1 -0.015 0.082 -10000 0 -0.19 3 3
GPC1/TGFB/TGFBR1/TGFBR2 0.011 0.072 -10000 0 -0.18 1 1
SERPINC1 0.003 0.081 -10000 0 -0.31 1 1
FYN -0.047 0.056 -10000 0 -0.19 1 1
FGR -0.035 0.041 -10000 0 -10000 0 0
positive regulation of MAPKKK cascade -0.061 0.081 -10000 0 -0.22 1 1
SLIT2 -0.11 0.16 -10000 0 -0.29 7 7
GPC1/NRG -0.009 0.087 -10000 0 -0.18 3 3
NRG1 -0.018 0.11 -10000 0 -0.31 2 2
GPC1/VEGF165 homodimer/VEGFR1 homodimer -0.002 0.058 -10000 0 -0.1 4 4
LYN -0.035 0.041 -10000 0 -10000 0 0
mol:Spermine -0.012 0.028 -10000 0 -0.12 1 1
cell growth -0.001 0.085 -10000 0 -0.18 2 2
BMP signaling pathway -0.01 0.051 0.19 1 -10000 0 1
SRC -0.035 0.041 -10000 0 -10000 0 0
TGFBR1 0.003 0.081 -10000 0 -0.31 1 1
mol:Cu2+ 0 0 -10000 0 -10000 0 0
PLA2G2A -0.011 0.092 -10000 0 -0.25 2 2
GPC1 0.01 0.051 -10000 0 -0.19 1 1
TGFBR1 (dimer) 0.003 0.08 -10000 0 -0.31 1 1
VEGFA 0 0 -10000 0 -10000 0 0
BLK -0.051 0.055 -10000 0 -0.18 1 1
HCK -0.073 0.073 -10000 0 -0.22 2 2
FGF2 -0.017 0.11 -10000 0 -0.31 2 2
FGFR1 0.012 0.051 -10000 0 -0.19 1 1
VEGFR1 homodimer -0.015 0.082 -10000 0 -0.19 3 3
TGFBR2 0.012 0.051 -10000 0 -0.19 1 1
cell death 0.01 0.053 -10000 0 -0.12 2 2
ATIII/GPC1 0.007 0.07 -10000 0 -0.17 2 2
PLA2G2A/GPC1 -0.003 0.076 -10000 0 -0.16 3 3
LCK -0.041 0.044 -10000 0 -10000 0 0
neuron differentiation -0.009 0.087 -10000 0 -0.18 3 3
PrPc/Cu2+ 0.019 0 -10000 0 -10000 0 0
APP 0.009 0.051 -10000 0 -0.19 1 1
TGFBR2 (dimer) 0.012 0.051 -10000 0 -0.19 1 1
EPO signaling pathway

Figure S22.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S22.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.034 0.094 -10000 0 -10000 0 0
CRKL 0.045 0.067 0.14 4 -10000 0 4
mol:DAG 0.02 0.051 -10000 0 -10000 0 0
HRAS 0.053 0.087 0.3 1 -10000 0 1
MAPK8 0.028 0.086 0.15 4 -0.17 1 5
RAP1A 0.035 0.063 0.14 3 -10000 0 3
GAB1 0.045 0.067 0.14 4 -10000 0 4
MAPK14 0.04 0.069 0.15 4 -10000 0 4
EPO 0.018 0.018 -10000 0 -10000 0 0
PLCG1 0.02 0.051 -10000 0 -10000 0 0
EPOR/TRPC2/IP3 Receptors 0.016 0.047 -10000 0 -0.16 1 1
RAPGEF1 0.023 0.006 -10000 0 -10000 0 0
EPO/EPOR (dimer)/SOCS3 0.012 0.063 -10000 0 -0.19 1 1
GAB1/SHC/GRB2/SOS1 0.072 0.051 -10000 0 -10000 0 0
EPO/EPOR (dimer) 0.019 0.036 -10000 0 -10000 0 0
IRS2 0.045 0.067 0.14 4 -10000 0 4
STAT1 0.018 0.071 -10000 0 -0.21 1 1
STAT5B 0.019 0.06 -10000 0 -10000 0 0
cell proliferation 0.016 0.087 0.15 4 -10000 0 4
GAB1/SHIP/PIK3R1/SHP2/SHC 0.018 0.036 -10000 0 -10000 0 0
TEC 0.035 0.081 0.14 4 -10000 0 4
SOCS3 0.001 0.08 -10000 0 -0.31 1 1
STAT1 (dimer) 0.018 0.07 -10000 0 -0.21 1 1
JAK2 0.021 0.017 -10000 0 -10000 0 0
PIK3R1 0.023 0.006 -10000 0 -10000 0 0
EPO/EPOR (dimer)/JAK2 0.024 0.044 -10000 0 -10000 0 0
EPO/EPOR 0.019 0.036 -10000 0 -10000 0 0
LYN 0.023 0.013 -10000 0 -10000 0 0
TEC/VAV2 0.041 0.076 -10000 0 -10000 0 0
elevation of cytosolic calcium ion concentration 0.016 0.047 -10000 0 -0.16 1 1
SHC1 0.023 0.006 -10000 0 -10000 0 0
EPO/EPOR (dimer)/LYN 0.03 0.042 -10000 0 -10000 0 0
mol:IP3 0.02 0.051 -10000 0 -10000 0 0
PI3K regualtory subunit polypeptide 1/IRS2/SHIP 0.05 0.065 -10000 0 -10000 0 0
SH2B3 -0.001 0.004 -10000 0 -10000 0 0
NFKB1 0.029 0.086 0.15 4 -0.17 1 5
EPO/EPOR (dimer)/JAK2/SOCS3 0.007 0.051 -10000 0 -0.16 1 1
PTPN6 0.047 0.073 0.16 4 -10000 0 4
TEC/VAV2/GRB2 0.064 0.053 -10000 0 -10000 0 0
EPOR 0.016 0.047 -10000 0 -0.16 1 1
INPP5D 0 0 -10000 0 -10000 0 0
mol:GDP 0.071 0.051 -10000 0 -10000 0 0
SOS1 0.025 0 -10000 0 -10000 0 0
PLCG2 0.01 0.051 -10000 0 -0.19 1 1
CRKL/CBL/C3G 0.061 0.061 -10000 0 -10000 0 0
VAV2 0.051 0.058 0.14 4 -10000 0 4
CBL 0.045 0.067 0.14 4 -10000 0 4
SHC/Grb2/SOS1 0.018 0.023 -10000 0 -10000 0 0
STAT5A 0.019 0.06 -10000 0 -10000 0 0
GRB2 0.022 0.008 -10000 0 -10000 0 0
STAT5 (dimer) 0.018 0.088 -10000 0 -0.28 1 1
LYN/PLCgamma2 0.025 0.042 -10000 0 -0.14 1 1
PTPN11 0.025 0 -10000 0 -10000 0 0
BTK 0.04 0.067 0.14 4 -10000 0 4
BCL2 -0.002 0.19 -10000 0 -0.72 1 1
amb2 Integrin signaling

Figure S23.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S23.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaM/beta2 Integrin/proMMP-2 -0.011 0.098 -9999 0 -0.33 1 1
alphaM/beta2 Integrin/GPIbA -0.011 0.098 -9999 0 -0.33 1 1
alphaM/beta2 Integrin/proMMP-9 -0.059 0.13 -9999 0 -0.28 3 3
PLAUR 0.025 0 -9999 0 -10000 0 0
HMGB1 0.016 0.024 -9999 0 -10000 0 0
alphaM/beta2 Integrin/Talin -0.014 0.097 -9999 0 -0.33 1 1
AGER 0.016 0.024 -9999 0 -10000 0 0
RAP1A 0.003 0.081 -9999 0 -0.31 1 1
SELPLG 0.004 0.081 -9999 0 -0.31 1 1
mol:LDL 0 0 -9999 0 -10000 0 0
alphaM/beta2 Integrin/RAGE/HMGB1 -0.014 0.11 -9999 0 -0.24 2 2
mol:GTP 0 0 -9999 0 -10000 0 0
MMP9 -0.064 0.14 -9999 0 -0.26 5 5
CYR61 0.003 0.081 -9999 0 -0.31 1 1
TLN1 0.022 0.008 -9999 0 -10000 0 0
Rap1/GTP -0.013 0.095 -9999 0 -0.23 1 1
RHOA 0.004 0.081 -9999 0 -0.31 1 1
P-selectin oligomer 0.003 0.08 -9999 0 -0.31 1 1
MYH2 -0.017 0.084 -9999 0 -0.22 1 1
MST1R -0.009 0.093 -9999 0 -0.25 2 2
leukocyte activation during inflammatory response -0.014 0.088 -9999 0 -0.28 1 1
APOB 0.012 0.051 -9999 0 -0.19 1 1
mol:GDP 0 0 -9999 0 -10000 0 0
complement component iC3b receptor activity 0 0 -9999 0 -10000 0 0
MMP2 0.023 0.006 -9999 0 -10000 0 0
JAM3 -0.001 0.07 -9999 0 -0.19 2 2
GP1BA 0.023 0.006 -9999 0 -10000 0 0
alphaM/beta2 Integrin/CTGF -0.016 0.12 -9999 0 -0.41 1 1
alphaM/beta2 Integrin -0.025 0.079 -9999 0 -0.26 1 1
JAM3 homodimer -0.001 0.07 -9999 0 -0.19 2 2
ICAM2 0.001 0.08 -9999 0 -0.31 1 1
ICAM1 0.025 0 -9999 0 -10000 0 0
phagocytosis triggered by activation of immune response cell surface activating receptor -0.025 0.079 -9999 0 -0.26 1 1
cell adhesion -0.011 0.098 -9999 0 -0.33 1 1
NFKB1 -0.031 0.12 -9999 0 -0.28 2 2
THY1 -0.001 0.07 -9999 0 -0.19 2 2
RhoA/GDP 0.004 0.055 -9999 0 -0.21 1 1
Lipoprotein(a) 0.025 0.033 -9999 0 -0.1 1 1
alphaM/beta2 Integrin/LRP/tPA -0.006 0.11 -9999 0 -0.38 1 1
IL6 -0.055 0.16 -9999 0 -0.41 2 2
ITGB2 -0.031 0.098 -9999 0 -0.22 3 3
elevation of cytosolic calcium ion concentration -0.031 0.12 -9999 0 -0.44 1 1
alphaM/beta2 Integrin/JAM2/JAM3 -0.022 0.097 -9999 0 -0.3 1 1
JAM2 0.022 0.008 -9999 0 -10000 0 0
alphaM/beta2 Integrin/ICAM1 -0.032 0.099 -9999 0 -0.29 1 1
alphaM/beta2 Integrin/uPA/Plg -0.036 0.13 -9999 0 -0.31 2 2
RhoA/GTP -0.012 0.057 -9999 0 -10000 0 0
positive regulation of phagocytosis -0.061 0.14 -9999 0 -0.49 1 1
Ron/MSP 0.001 0.077 -9999 0 -0.16 3 3
alphaM/beta2 Integrin/uPAR/uPA -0.031 0.12 -9999 0 -0.44 1 1
alphaM/beta2 Integrin/uPAR -0.011 0.098 -9999 0 -0.33 1 1
PLAU -0.024 0.1 -9999 0 -0.23 3 3
PLAT 0.012 0.051 -9999 0 -0.19 1 1
actin filament polymerization -0.021 0.084 -9999 0 -0.21 1 1
MST1 0.012 0.051 -9999 0 -0.19 1 1
alphaM/beta2 Integrin/lipoprotein(a) -0.012 0.091 -9999 0 -0.29 1 1
TNF -0.038 0.11 -9999 0 -10000 0 0
RAP1B 0.012 0.051 -9999 0 -0.19 1 1
alphaM/beta2 Integrin/uPA -0.04 0.13 -9999 0 -0.48 1 1
fibrinolysis -0.036 0.13 -9999 0 -0.31 2 2
HCK -0.056 0.12 -9999 0 -0.24 5 5
dendritic cell antigen processing and presentation -0.025 0.079 -9999 0 -0.26 1 1
VTN 0.025 0 -9999 0 -10000 0 0
alphaM/beta2 Integrin/CYR61 -0.021 0.11 -9999 0 -0.28 2 2
LPA 0.025 0 -9999 0 -10000 0 0
LRP1 0.025 0 -9999 0 -10000 0 0
cell migration -0.057 0.12 -9999 0 -0.26 3 3
FN1 0.012 0.051 -9999 0 -0.19 1 1
alphaM/beta2 Integrin/Thy1 -0.021 0.099 -9999 0 -0.33 1 1
MPO 0.022 0.008 -9999 0 -10000 0 0
KNG1 0.025 0 -9999 0 -10000 0 0
RAP1/GDP 0.01 0.059 -9999 0 -0.14 2 2
ROCK1 0.003 0.079 -9999 0 -10000 0 0
ELA2 0.025 0 -9999 0 -10000 0 0
PLG 0.012 0.051 -9999 0 -0.19 1 1
CTGF 0.012 0.051 -9999 0 -0.19 1 1
alphaM/beta2 Integrin/Hck -0.046 0.14 -9999 0 -0.26 4 4
ITGAM -0.008 0.08 -9999 0 -0.31 1 1
alphaM/beta2 Integrin/P-Selectin/PSGL1 -0.024 0.13 -9999 0 -0.3 2 2
HP -0.011 0.092 -9999 0 -0.25 2 2
leukocyte adhesion -0.038 0.097 -9999 0 -0.31 1 1
SELP 0.003 0.081 -9999 0 -0.31 1 1
Ceramide signaling pathway

Figure S24.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S24.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 -0.028 0.056 -10000 0 -0.17 2 2
MAP4K4 -0.035 0.1 -10000 0 -0.33 1 1
BAG4 0.025 0 -10000 0 -10000 0 0
PKC zeta/ceramide -0.046 0.081 -10000 0 -0.18 4 4
NFKBIA 0.023 0.006 -10000 0 -10000 0 0
BIRC3 -0.051 0.13 -10000 0 -0.28 4 4
BAX -0.01 0.038 -10000 0 -10000 0 0
RIPK1 0.025 0 -10000 0 -10000 0 0
AKT1 0.003 0.013 -10000 0 -10000 0 0
BAD -0.057 0.085 -10000 0 -0.18 5 5
SMPD1 -0.021 0.055 -10000 0 -0.2 1 1
RB1 -0.049 0.081 -10000 0 -0.18 4 4
FADD/Caspase 8 -0.033 0.099 -10000 0 -0.33 1 1
MAP2K4 -0.061 0.079 -10000 0 -0.18 5 5
NSMAF 0.025 0 -10000 0 -10000 0 0
response to UV 0 0 -10000 0 -10000 0 0
RAF1 -0.049 0.077 -10000 0 -0.18 4 4
EGF -0.056 0.12 -10000 0 -0.24 5 5
mol:ceramide -0.048 0.087 -10000 0 -0.19 4 4
MADD 0.023 0.006 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
mol:Free Fatty acid -0.033 0.078 -10000 0 -0.31 1 1
ASAH1 -0.011 0.092 -10000 0 -0.25 2 2
negative regulation of cell cycle -0.048 0.08 -10000 0 -0.18 4 4
cell proliferation -0.043 0.076 -10000 0 -0.16 4 4
BID -0.056 0.18 -10000 0 -0.67 1 1
MAP3K1 -0.061 0.083 -10000 0 -0.18 5 5
EIF2A -0.05 0.074 -10000 0 -0.17 4 4
TRADD 0.023 0.006 -10000 0 -10000 0 0
CRADD 0.004 0.081 -10000 0 -0.31 1 1
MAPK3 -0.047 0.072 -10000 0 -0.16 4 4
response to heat 0 0 -10000 0 -10000 0 0
MAPK1 -0.046 0.073 -10000 0 -0.16 4 4
Cathepsin D/ceramide -0.04 0.088 -10000 0 -0.18 4 4
FADD -0.035 0.1 -10000 0 -0.33 1 1
KSR1 -0.049 0.081 -10000 0 -0.18 4 4
MAPK8 -0.063 0.082 -10000 0 -0.17 5 5
PRKRA -0.049 0.081 -10000 0 -0.18 4 4
PDGFA -0.015 0.091 -10000 0 -0.25 2 2
TRAF2 0.023 0.006 -10000 0 -10000 0 0
IGF1 0.012 0.051 -10000 0 -0.19 1 1
mol:GD3 0 0 -10000 0 -10000 0 0
ganglioside biosynthetic process -0.048 0.086 -10000 0 -0.19 4 4
CTSD 0.025 0 -10000 0 -10000 0 0
regulation of nitric oxide biosynthetic process 0.021 0.061 -10000 0 -0.21 1 1
response to radiation 0 0 -10000 0 -10000 0 0
ERK1/PKC delta -0.045 0.08 -10000 0 -0.17 4 4
PRKCD 0.025 0 -10000 0 -10000 0 0
PRKCZ 0 0 -10000 0 -10000 0 0
mol:GW4869 0 0 -10000 0 -10000 0 0
mol:sphingosine -0.033 0.078 -10000 0 -0.31 1 1
RelA/NF kappa B1 0.022 0.061 -10000 0 -0.21 1 1
mol:glutathione 0 0 -10000 0 -10000 0 0
PAWR 0.025 0 -10000 0 -10000 0 0
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD -0.038 0.1 -10000 0 -0.34 1 1
TNFR1A/BAG4/TNF-alpha 0.041 0.038 -10000 0 -10000 0 0
mol:Sphingosine-1-phosphate -0.028 0.056 -10000 0 -0.17 2 2
MAP2K1 -0.05 0.074 -10000 0 -0.17 4 4
mol:C11AG 0 0 -10000 0 -10000 0 0
RELA 0.025 0 -10000 0 -10000 0 0
CYCS 0.001 0.044 -10000 0 -10000 0 0
TNFRSF1A 0.025 0 -10000 0 -10000 0 0
NFKB1 0.004 0.081 -10000 0 -0.31 1 1
TNFR1A/BAG4 0.037 0 -10000 0 -10000 0 0
EIF2AK2 -0.049 0.077 -10000 0 -0.18 4 4
TNF-alpha/TNFR1A/FAN 0.041 0.038 -10000 0 -10000 0 0
response to hydrogen peroxide 0 0 -10000 0 -10000 0 0
CASP8 -0.011 0.076 -10000 0 -10000 0 0
MAP2K2 -0.05 0.074 -10000 0 -0.17 4 4
SMPD3 -0.01 0.038 -10000 0 -10000 0 0
TNF 0.012 0.051 -10000 0 -0.19 1 1
PKC zeta/PAR4 0.019 0 -10000 0 -10000 0 0
mol:PHOSPHOCHOLINE 0.007 0.093 0.15 3 -0.12 4 7
NF kappa B1/RelA/I kappa B alpha 0.043 0.053 -10000 0 -0.15 1 1
AIFM1 -0.023 0.068 -10000 0 -10000 0 0
BCL2 0.001 0.08 -10000 0 -0.31 1 1
Reelin signaling pathway

Figure S25.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S25.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDK5R1/CDK5 0.028 0.016 -10000 0 -10000 0 0
VLDLR -0.018 0.11 -10000 0 -0.31 2 2
CRKL 0.025 0 -10000 0 -10000 0 0
LRPAP1 0.025 0 -10000 0 -10000 0 0
FYN -0.001 0.07 -10000 0 -0.19 2 2
ITGA3 0.025 0 -10000 0 -10000 0 0
RELN/VLDLR/Fyn -0.037 0.13 -10000 0 -0.24 4 4
MAPK8IP1/MKK7/MAP3K11/JNK1 0.04 0.068 -10000 0 -0.16 1 1
AKT1 -0.047 0.099 -10000 0 -0.21 4 4
MAP2K7 0.025 0 -10000 0 -10000 0 0
RAPGEF1 0.023 0.006 -10000 0 -10000 0 0
DAB1 0.023 0.006 -10000 0 -10000 0 0
RELN/LRP8/DAB1 -0.009 0.076 -10000 0 -0.16 3 3
LRPAP1/LRP8 0.025 0.04 -10000 0 -0.13 1 1
RELN/LRP8/DAB1/Fyn -0.007 0.088 -10000 0 -0.18 3 3
DAB1/alpha3/beta1 Integrin -0.024 0.1 -10000 0 -0.28 1 1
long-term memory -0.009 0.097 -10000 0 -0.22 1 1
DAB1/LIS1 -0.019 0.1 -10000 0 -0.28 1 1
DAB1/CRLK/C3G -0.023 0.099 -10000 0 -0.28 1 1
PIK3CA 0.025 0 -10000 0 -10000 0 0
DAB1/NCK2 -0.033 0.11 -10000 0 -0.28 1 1
ARHGEF2 0.01 0.051 -10000 0 -0.19 1 1
mol:Src family inhibitors PP1 and PP2 0 0 -10000 0 -10000 0 0
GRIN2A 0.022 0.008 -10000 0 -10000 0 0
CDK5R1 0.025 0 -10000 0 -10000 0 0
RELN -0.045 0.13 -10000 0 -0.31 3 3
PIK3R1 0.023 0.006 -10000 0 -10000 0 0
RELN/LRP8/Fyn -0.017 0.097 -10000 0 -0.21 3 3
GRIN2A/RELN/LRP8/DAB1/Fyn -0.006 0.092 -10000 0 -0.18 3 3
MAPK8 0.003 0.081 -10000 0 -0.31 1 1
RELN/VLDLR/DAB1 -0.031 0.1 -10000 0 -0.2 4 4
ITGB1 0.023 0.006 -10000 0 -10000 0 0
MAP1B -0.015 0.13 0.15 4 -0.3 1 5
RELN/LRP8 -0.012 0.084 -10000 0 -0.18 3 3
GRIN2B/RELN/LRP8/DAB1/Fyn -0.013 0.094 -10000 0 -0.18 3 3
PI3K 0.035 0.009 -10000 0 -10000 0 0
mol:PP2 0 0 -10000 0 -10000 0 0
alpha3/beta1 Integrin 0.035 0.009 -10000 0 -10000 0 0
RAP1A -0.016 0.14 -10000 0 -0.27 2 2
PAFAH1B1 0.023 0.006 -10000 0 -10000 0 0
MAPK8IP1 0.023 0.006 -10000 0 -10000 0 0
CRLK/C3G 0.035 0.009 -10000 0 -10000 0 0
GRIN2B -0.007 0.069 -10000 0 -0.19 2 2
NCK2 -0.017 0.11 -10000 0 -0.31 2 2
neuron differentiation -0.005 0.087 -10000 0 -0.2 1 1
neuron adhesion -0.019 0.13 -10000 0 -0.26 2 2
LRP8 0.01 0.051 -10000 0 -0.19 1 1
GSK3B -0.042 0.1 -10000 0 -0.2 4 4
RELN/VLDLR/DAB1/Fyn -0.029 0.12 -10000 0 -0.21 4 4
MAP3K11 0.025 0 -10000 0 -10000 0 0
RELN/VLDLR/DAB1/P13K -0.046 0.11 -10000 0 -0.22 4 4
CDK5 0.019 0.011 -10000 0 -10000 0 0
MAPT 0.003 0.013 -10000 0 -10000 0 0
neuron migration -0.032 0.16 0.21 3 -0.29 3 6
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 -0.005 0.087 -10000 0 -0.2 1 1
RELN/VLDLR -0.026 0.11 -10000 0 -0.2 4 4
Ephrin B reverse signaling

Figure S26.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S26.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EFNB2 0.025 0 -10000 0 -10000 0 0
EPHB2 -0.019 0.11 -10000 0 -0.31 2 2
EFNB1 -0.032 0.052 -10000 0 -0.16 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP -0.006 0.069 -10000 0 -10000 0 0
Ephrin B2/EPHB1-2 0.009 0.075 -10000 0 -0.17 2 2
neuron projection morphogenesis -0.012 0.06 -10000 0 -10000 0 0
Ephrin B1/EPHB1-2/Tiam1 -0.014 0.081 -10000 0 -0.16 2 2
DNM1 -0.011 0.091 -10000 0 -0.24 2 2
cell-cell signaling -0.001 0.002 -10000 0 -10000 0 0
MAP2K4 -0.038 0.14 -10000 0 -0.56 1 1
YES1 -0.042 0.19 -10000 0 -0.76 1 1
Ephrin B1/EPHB1-2/NCK2 -0.033 0.11 -10000 0 -0.21 3 3
PI3K -0.005 0.14 -10000 0 -0.56 1 1
mol:GDP -0.014 0.08 -10000 0 -0.16 2 2
ITGA2B 0.023 0.006 -10000 0 -10000 0 0
endothelial cell proliferation 0.025 0.014 -10000 0 -10000 0 0
FYN -0.034 0.19 -10000 0 -0.76 1 1
MAP3K7 -0.037 0.14 -10000 0 -0.59 1 1
FGR -0.033 0.18 -10000 0 -0.74 1 1
TIAM1 0.022 0.008 -10000 0 -10000 0 0
PIK3R1 0.023 0.006 -10000 0 -10000 0 0
RGS3 0.023 0.006 -10000 0 -10000 0 0
cell adhesion -0.039 0.14 -10000 0 -0.53 1 1
LYN -0.032 0.19 -10000 0 -0.76 1 1
Ephrin B1/EPHB1-2/Src Family Kinases -0.037 0.17 -10000 0 -0.7 1 1
Ephrin B1/EPHB1-2 -0.037 0.15 -10000 0 -0.63 1 1
SRC -0.033 0.18 -10000 0 -0.74 1 1
ITGB3 -0.022 0.1 -10000 0 -0.23 3 3
EPHB1 0.011 0.051 -10000 0 -0.19 1 1
EPHB4 0.019 0.011 -10000 0 -10000 0 0
RAC1 0.019 0.011 -10000 0 -10000 0 0
Ephrin B2/EPHB4 0.025 0.015 -10000 0 -10000 0 0
alphaIIb/beta3 Integrin -0.001 0.077 -10000 0 -0.16 3 3
BLK -0.044 0.19 -10000 0 -0.75 1 1
HCK -0.056 0.19 -10000 0 -0.77 1 1
regulation of stress fiber formation 0.034 0.11 0.21 3 -10000 0 3
MAPK8 -0.047 0.13 -10000 0 -0.54 1 1
Ephrin B1/EPHB1-2/RGS3 -0.011 0.084 -10000 0 -0.16 2 2
endothelial cell migration 0.009 0.15 0.18 3 -0.5 1 4
NCK2 -0.017 0.11 -10000 0 -0.31 2 2
PTPN13 0.001 0.11 -10000 0 -0.43 1 1
regulation of focal adhesion formation 0.034 0.11 0.21 3 -10000 0 3
chemotaxis 0.012 0.083 0.16 2 -10000 0 2
PIK3CA 0.025 0 -10000 0 -10000 0 0
Rac1/GTP -0.009 0.065 -10000 0 -10000 0 0
angiogenesis -0.037 0.15 -10000 0 -0.63 1 1
LCK -0.034 0.19 -10000 0 -0.76 1 1
Signaling mediated by p38-gamma and p38-delta

Figure S27.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S27.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EEF2K -0.028 0.046 -10000 0 -0.18 1 1
SNTA1 0.025 0 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
STMN1 -0.028 0.045 -10000 0 -0.18 1 1
MAPK12 0.01 0.085 0.2 2 -0.19 1 3
CCND1 0.01 0.04 -10000 0 -10000 0 0
p38 gamma/SNTA1 0.025 0.077 0.19 2 -0.18 1 3
MAP2K3 0.003 0.081 -10000 0 -0.31 1 1
PKN1 0.004 0.081 -10000 0 -0.31 1 1
G2/M transition checkpoint 0.01 0.085 0.2 2 -0.19 1 3
MAP2K6 -0.009 0.05 -10000 0 -0.2 1 1
MAPT -0.009 0.058 -10000 0 -0.23 1 1
MAPK13 -0.03 0.055 -10000 0 -0.21 1 1
hyperosmotic response 0 0 -10000 0 -10000 0 0
ZAK -0.003 0.06 -10000 0 -0.24 1 1
Signaling mediated by p38-alpha and p38-beta

Figure S28.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S28.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTGS2 -0.006 0.1 -10000 0 -0.39 1 1
MKNK1 0.023 0.006 -10000 0 -10000 0 0
MAPK14 0.021 0.036 -10000 0 -10000 0 0
ATF2/c-Jun -0.013 0.077 -10000 0 -10000 0 0
MAPK11 0 0.11 -10000 0 -0.4 1 1
MITF -0.013 0.097 -10000 0 -0.26 2 2
MAPKAPK5 0.003 0.081 -10000 0 -0.3 1 1
KRT8 -0.033 0.11 -10000 0 -0.25 3 3
MAPKAPK3 0.004 0.081 -10000 0 -0.31 1 1
MAPKAPK2 0.023 0.006 -10000 0 -10000 0 0
p38alpha-beta/CK2 0.017 0.09 -10000 0 -0.3 1 1
CEBPB 0.003 0.081 -10000 0 -0.3 1 1
SLC9A1 0.003 0.081 -10000 0 -0.3 1 1
mol:GDP 0 0 -10000 0 -10000 0 0
ATF2 0.004 0.089 -10000 0 -0.3 1 1
p38alpha-beta/MNK1 0.024 0.076 -10000 0 -0.24 1 1
JUN -0.016 0.075 -10000 0 -10000 0 0
PPARGC1A -0.028 0.11 -10000 0 -0.25 3 3
USF1 -0.043 0.1 -10000 0 -0.25 3 3
RAB5/GDP/GDI1 0.012 0.063 -10000 0 -0.22 1 1
NOS2 -0.002 0.08 -10000 0 -0.3 1 1
DDIT3 -0.013 0.097 -10000 0 -0.26 2 2
RAB5A 0.025 0 -10000 0 -10000 0 0
HSPB1 0.058 0.14 0.27 4 -0.25 1 5
p38alpha-beta/HBP1 0.012 0.076 -10000 0 -0.24 1 1
CREB1 -0.002 0.084 -10000 0 -0.32 1 1
RAB5/GDP 0.019 0 -10000 0 -10000 0 0
EIF4E 0.009 0.079 0.23 1 -0.21 1 2
RPS6KA4 0.003 0.081 -10000 0 -0.3 1 1
PLA2G4A -0.04 0.083 -10000 0 -0.21 1 1
GDI1 0.003 0.081 -10000 0 -0.3 1 1
TP53 -0.022 0.084 -10000 0 -0.32 1 1
RPS6KA5 -0.004 0.078 -10000 0 -0.3 1 1
ESR1 -0.028 0.11 -10000 0 -0.25 3 3
HBP1 0.017 0.012 -10000 0 -10000 0 0
MEF2C -0.017 0.1 -10000 0 -0.28 2 2
MEF2A 0.003 0.081 -10000 0 -0.3 1 1
EIF4EBP1 -0.002 0.084 -10000 0 -0.32 1 1
KRT19 -0.029 0.094 -10000 0 -0.26 2 2
ELK4 -0.002 0.078 -10000 0 -0.3 1 1
ATF6 -0.002 0.078 -10000 0 -0.3 1 1
ATF1 -0.002 0.084 -10000 0 -0.32 1 1
p38alpha-beta/MAPKAPK2 0.024 0.076 -10000 0 -0.24 1 1
p38alpha-beta/MAPKAPK3 0.021 0.11 -10000 0 -0.4 1 1
Integrins in angiogenesis

Figure S29.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S29.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0.01 0.034 -10000 0 -0.12 1 1
alphaV beta3 Integrin -0.022 0.11 -10000 0 -0.2 4 4
PTK2 -0.069 0.13 -10000 0 -0.32 2 2
IGF1R 0.025 0 -10000 0 -10000 0 0
PI4KB 0 0 -10000 0 -10000 0 0
MFGE8 0.025 0 -10000 0 -10000 0 0
SRC 0.025 0 -10000 0 -10000 0 0
CDKN1B -0.007 0.045 -10000 0 -10000 0 0
VEGFA 0 0 -10000 0 -10000 0 0
ILK -0.007 0.045 -10000 0 -10000 0 0
ROCK1 0.023 0.006 -10000 0 -10000 0 0
AKT1 -0.014 0.039 -10000 0 -10000 0 0
PTK2B -0.045 0.062 -10000 0 -0.23 1 1
alphaV/beta3 Integrin/JAM-A -0.015 0.1 -10000 0 -0.18 4 4
CBL 0.025 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
alphaV beta3 Integrin/ANGPTL3 -0.026 0.12 -10000 0 -0.24 3 3
IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.045 0.051 -10000 0 -10000 0 0
VEGF/Rho/ROCK/alphaV/beta3 Integrin -0.022 0.095 -10000 0 -0.25 2 2
alphaV/beta3 Integrin/Syndecan-1 -0.003 0.099 -10000 0 -0.22 2 2
PI4KA 0 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 -0.03 0.11 -10000 0 -0.22 2 2
PI4 Kinase 0 0 -10000 0 -10000 0 0
PIK3CA 0.025 0 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Osteopontin -0.036 0.12 -10000 0 -0.2 5 5
RPS6KB1 -0.056 0.06 -10000 0 -0.21 1 1
TLN1 0.022 0.008 -10000 0 -10000 0 0
MAPK3 -0.08 0.16 -10000 0 -0.39 3 3
GPR124 0.023 0.006 -10000 0 -10000 0 0
MAPK1 -0.079 0.18 -10000 0 -0.38 4 4
PXN 0.025 0 -10000 0 -10000 0 0
PIK3R1 0.023 0.006 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Tumstatin -0.011 0.1 -10000 0 -0.21 3 3
cell adhesion -0.025 0.11 -10000 0 -0.23 3 3
ANGPTL3 -0.024 0.1 -10000 0 -0.23 3 3
VEGFR2 homodimer/VEGFA homodimer/Src 0.025 0.033 -10000 0 -0.1 1 1
IGF-1R heterotetramer 0.025 0 -10000 0 -10000 0 0
Rac1/GDP 0.014 0.008 -10000 0 -10000 0 0
TGFBR2 0.012 0.051 -10000 0 -0.19 1 1
ITGB3 -0.022 0.1 -10000 0 -0.23 3 3
IGF1 0.012 0.051 -10000 0 -0.19 1 1
RAC1 0.019 0.011 -10000 0 -10000 0 0
regulation of cell-matrix adhesion 0.003 0.095 -10000 0 -0.22 2 2
apoptosis 0.004 0.081 -10000 0 -0.31 1 1
CD47 0.025 0 -10000 0 -10000 0 0
alphaV/beta3 Integrin/CD47 0.007 0.096 -10000 0 -0.22 2 2
VCL 0.023 0.006 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Del1 -0.075 0.13 -10000 0 -0.22 6 6
CSF1 0.023 0.006 -10000 0 -10000 0 0
PIK3C2A -0.024 0.094 -10000 0 -0.35 1 1
PI4 Kinase/Pyk2 -0.032 0.088 -10000 0 -0.17 4 4
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.001 0.09 -10000 0 -0.2 2 2
FAK1/Vinculin -0.062 0.11 -10000 0 -0.27 2 2
alphaV beta3/Integrin/ppsTEM5 0.004 0.095 -10000 0 -0.22 2 2
RHOA 0.004 0.081 -10000 0 -0.31 1 1
VTN 0.025 0 -10000 0 -10000 0 0
BCAR1 0.023 0.006 -10000 0 -10000 0 0
FGF2 -0.017 0.11 -10000 0 -0.31 2 2
F11R -0.036 0.067 -10000 0 -0.21 2 2
alphaV/beta3 Integrin/Lactadherin 0.007 0.096 -10000 0 -0.22 2 2
alphaV/beta3 Integrin/TGFBR2 0.001 0.1 -10000 0 -0.21 3 3
alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.042 0.058 -10000 0 -0.16 1 1
HSP90AA1 0 0 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Talin 0.002 0.086 -10000 0 -0.2 2 2
mol:GDP 0 0 -10000 0 -10000 0 0
FN1 0.012 0.051 -10000 0 -0.19 1 1
alphaV/beta3 Integrin/Pyk2 -0.006 0.084 -10000 0 -0.19 2 2
SDC1 0.012 0.051 -10000 0 -0.19 1 1
VAV3 -0.013 0.059 0.17 1 -10000 0 1
PTPN11 0.025 0 -10000 0 -10000 0 0
IRS1 0.01 0.051 -10000 0 -0.19 1 1
FAK1/Paxillin -0.051 0.12 -10000 0 -0.27 2 2
cell migration -0.061 0.096 -10000 0 -0.25 2 2
ITGAV 0.004 0.081 -10000 0 -0.31 1 1
PI3K -0.006 0.1 -10000 0 -0.22 1 1
SPP1 -0.038 0.13 -10000 0 -0.31 3 3
KDR 0.012 0.051 -10000 0 -0.19 1 1
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Caspase 8 0.004 0.081 -10000 0 -0.31 1 1
COL4A3 0.003 0.081 -10000 0 -0.31 1 1
angiogenesis -0.084 0.16 -10000 0 -0.41 3 3
Rac1/GTP 0.014 0.056 0.17 1 -10000 0 1
EDIL3 -0.1 0.14 -10000 0 -0.26 7 7
cell proliferation 0.001 0.1 -10000 0 -0.21 3 3
TCR signaling in naïve CD8+ T cells

Figure S30.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S30.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GRB2/SOS1/SHC -0.032 0.11 -10000 0 -0.37 1 1
FYN -0.058 0.14 -10000 0 -0.54 1 1
LAT/GRAP2/SLP76 -0.032 0.11 -10000 0 -0.3 2 2
IKBKB 0.025 0 -10000 0 -10000 0 0
AKT1 -0.023 0.11 0.21 1 -0.36 1 2
B2M -0.034 0.12 -10000 0 -0.27 3 3
IKBKG 0.007 0.05 -10000 0 -0.11 1 1
MAP3K8 0.023 0.006 -10000 0 -10000 0 0
mol:Ca2+ -0.012 0.013 -10000 0 -0.043 1 1
integrin-mediated signaling pathway 0.005 0.069 -10000 0 -0.18 2 2
LAT/GRAP2/SLP76/VAV1/PI3K Class IA -0.042 0.14 -10000 0 -0.5 1 1
TRPV6 0.27 0.47 1.1 4 -10000 0 4
CD28 -0.01 0.094 -10000 0 -0.25 2 2
SHC1 -0.049 0.12 -10000 0 -0.43 1 1
receptor internalization -0.041 0.12 -10000 0 -0.44 1 1
PRF1 -0.11 0.27 -10000 0 -0.76 2 2
KRAS 0.025 0 -10000 0 -10000 0 0
GRB2 0.022 0.008 -10000 0 -10000 0 0
COT/AKT1 -0.009 0.1 0.2 1 -0.29 1 2
LAT -0.028 0.13 -10000 0 -0.43 1 1
EntrezGene:6955 -0.002 0.006 -10000 0 -0.022 1 1
CD3D 0.008 0.054 -10000 0 -0.19 1 1
CD3E 0.019 0.017 -10000 0 -10000 0 0
CD3G -0.013 0.094 -10000 0 -0.25 2 2
RASGRP2 -0.001 0.011 -10000 0 -10000 0 0
RASGRP1 -0.038 0.12 0.22 1 -0.34 1 2
HLA-A 0.008 0.054 -10000 0 -0.19 1 1
RASSF5 0.003 0.081 -10000 0 -0.31 1 1
RAP1A/GTP/RAPL 0.006 0.069 -10000 0 -0.18 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
mol:GDP 0.006 0.054 0.17 1 -10000 0 1
PDK1/CARD11/BCL10/MALT1/TRAF6 -0.021 0.052 -10000 0 -0.19 1 1
PRKCA -0.031 0.064 -10000 0 -0.23 1 1
GRAP2 0.023 0.006 -10000 0 -10000 0 0
mol:IP3 -0.035 0.1 -10000 0 -0.27 2 2
EntrezGene:6957 -0.002 0.006 -10000 0 -0.022 1 1
TCR/CD3/MHC I/CD8 -0.037 0.1 -10000 0 -0.25 2 2
ORAI1 -0.24 0.39 -10000 0 -0.91 4 4
CSK -0.048 0.12 -10000 0 -0.43 1 1
B7 family/CD28 -0.043 0.18 -10000 0 -0.38 3 3
CHUK 0.003 0.081 -10000 0 -0.31 1 1
TCR/CD3/MHC I/CD8/LCK/ZAP-70 -0.049 0.13 -10000 0 -0.47 1 1
PTPN6 -0.056 0.12 -10000 0 -0.44 1 1
VAV1 -0.055 0.14 -10000 0 -0.54 1 1
Monovalent TCR/CD3 -0.011 0.058 -10000 0 -0.19 1 1
CBL 0.025 0 -10000 0 -10000 0 0
LCK -0.056 0.13 -10000 0 -0.48 1 1
PAG1 -0.052 0.13 -10000 0 -0.49 1 1
RAP1A 0.003 0.081 -10000 0 -0.31 1 1
TCR/CD3/MHC I/CD8/LCK -0.053 0.13 -10000 0 -0.48 1 1
CD80 0.025 0.001 -10000 0 -10000 0 0
CD86 0.004 0.082 -10000 0 -0.31 1 1
PDK1/CARD11/BCL10/MALT1 -0.021 0.063 -10000 0 -0.22 1 1
HRAS 0.025 0 -10000 0 -10000 0 0
GO:0035030 -0.062 0.15 -10000 0 -0.33 3 3
CD8A -0.002 0.006 -10000 0 -0.022 1 1
CD8B -0.002 0.006 -10000 0 -0.023 1 1
PTPRC -0.011 0.093 -10000 0 -0.25 2 2
PDK1/PKC theta -0.022 0.15 0.33 1 -0.43 1 2
CSK/PAG1 -0.05 0.12 -10000 0 -0.46 1 1
SOS1 0.025 0 -10000 0 -10000 0 0
peptide-MHC class I -0.02 0.094 -10000 0 -0.19 3 3
GRAP2/SLP76 -0.039 0.13 -10000 0 -0.33 2 2
STIM1 -0.073 0.1 -10000 0 -10000 0 0
RAS family/GTP -0.011 0.05 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin -0.043 0.12 -10000 0 -0.46 1 1
mol:DAG -0.037 0.09 -10000 0 -0.25 2 2
RAP1A/GDP -0.003 0.025 -10000 0 -0.07 1 1
PLCG1 0.012 0.051 -10000 0 -0.19 1 1
CD247 -0.002 0.006 -10000 0 -0.022 1 1
cytotoxic T cell degranulation -0.11 0.26 -10000 0 -0.73 2 2
RAP1A/GTP -0.003 0.014 -10000 0 -0.053 1 1
mol:PI-3-4-5-P3 -0.035 0.12 -10000 0 -0.42 1 1
LAT/GRAP2/SLP76/VAV1/PLCgamma1 -0.041 0.13 -10000 0 -0.34 2 2
NRAS 0.003 0.081 -10000 0 -0.31 1 1
ZAP70 0.025 0 -10000 0 -10000 0 0
GRB2/SOS1 0.033 0.012 -10000 0 -10000 0 0
LAT/GRAP2/SLP76/VAV1 -0.044 0.12 -10000 0 -0.33 2 2
MALT1 0.023 0.006 -10000 0 -10000 0 0
TRAF6 0.023 0.006 -10000 0 -10000 0 0
CD8 heterodimer -0.002 0.008 -10000 0 -0.031 1 1
CARD11 0.019 0.011 -10000 0 -10000 0 0
PRKCB -0.033 0.062 -10000 0 -0.18 2 2
PRKCE -0.03 0.065 -10000 0 -0.23 1 1
PRKCQ -0.042 0.14 0.19 1 -0.48 1 2
LCP2 0.009 0.051 -10000 0 -0.19 1 1
BCL10 0.023 0.006 -10000 0 -10000 0 0
regulation of survival gene product expression -0.021 0.1 0.2 1 -0.31 1 2
IKK complex 0.012 0.061 0.2 1 -10000 0 1
RAS family/GDP -0.004 0.014 -10000 0 -0.043 1 1
MAP3K14 -0.017 0.086 0.17 1 -0.23 1 2
PDPK1 -0.018 0.12 0.28 1 -0.34 1 2
TCR/CD3/MHC I/CD8/Fyn -0.049 0.13 -10000 0 -0.35 2 2
Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Figure S31.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S31.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FOXP3 0.023 0.025 -10000 0 -10000 0 0
NFATC2 -0.083 0.18 -10000 0 -0.42 2 2
NFATC3 -0.058 0.097 -10000 0 -0.24 2 2
CD40LG -0.24 0.28 -10000 0 -0.7 3 3
ITCH 0.006 0.053 -10000 0 -10000 0 0
CBLB 0.006 0.053 -10000 0 -10000 0 0
CD4-positive CD25-positive alpha-beta regulatory T cell lineage commitment -0.16 0.24 -10000 0 -0.85 1 1
JUNB -0.001 0.07 -10000 0 -0.19 2 2
CaM/Ca2+/Calcineurin A alpha-beta B1 0.011 0.066 -10000 0 -0.21 1 1
T cell anergy -0.016 0.077 -10000 0 -0.29 1 1
TLE4 -0.065 0.12 -10000 0 -10000 0 0
Jun/NFAT1-c-4/p21SNFT -0.18 0.29 -10000 0 -0.63 4 4
AP-1/NFAT1-c-4 -0.22 0.35 -10000 0 -0.78 3 3
IKZF1 -0.056 0.11 -10000 0 -0.28 2 2
T-helper 2 cell differentiation -0.14 0.32 -10000 0 -1.2 1 1
AP-1/NFAT1 -0.068 0.16 -10000 0 -0.34 2 2
CALM1 0.014 0.046 -10000 0 -10000 0 0
EGR2 -0.2 0.31 -10000 0 -0.84 2 2
EGR3 -0.26 0.43 -10000 0 -1.1 3 3
NFAT1/FOXP3 -0.039 0.13 -10000 0 -0.28 2 2
EGR1 -0.034 0.12 -10000 0 -0.27 3 3
JUN -0.018 0.072 -10000 0 -0.19 2 2
EGR4 0 0.003 -10000 0 -10000 0 0
mol:Ca2+ -0.003 0.035 -10000 0 -0.12 1 1
GBP3 -0.061 0.16 -10000 0 -0.59 1 1
FOSL1 0.025 0 -10000 0 -10000 0 0
NFAT1-c-4/MAF/IRF4 -0.18 0.3 -10000 0 -0.65 4 4
DGKA -0.055 0.11 -10000 0 -0.29 1 1
CREM 0.025 0 -10000 0 -10000 0 0
NFAT1-c-4/PPARG -0.18 0.29 -10000 0 -0.66 4 4
CTLA4 -0.051 0.1 -10000 0 -10000 0 0
NFAT1-c-4 (dimer)/EGR1 -0.2 0.32 -10000 0 -0.69 4 4
NFAT1-c-4 (dimer)/EGR4 -0.19 0.29 -10000 0 -0.66 4 4
FOS -0.049 0.12 -10000 0 -0.28 3 3
IFNG -0.12 0.18 -10000 0 -0.61 1 1
T cell activation -0.13 0.2 -10000 0 -0.56 2 2
MAF 0.01 0.051 -10000 0 -0.19 1 1
T-helper 2 cell lineage commitment 0 0 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.16 0.23 0.52 4 -10000 0 4
TNF -0.2 0.28 -10000 0 -0.64 4 4
FASLG -0.26 0.37 -10000 0 -0.86 4 4
TBX21 -0.043 0.1 -10000 0 -0.21 4 4
BATF3 0 0 -10000 0 -10000 0 0
PRKCQ 0.002 0.053 -10000 0 -0.18 1 1
PTPN1 -0.055 0.11 -10000 0 -10000 0 0
NFAT1-c-4/ICER1 -0.18 0.3 -10000 0 -0.66 4 4
GATA3 0.012 0.051 -10000 0 -0.18 1 1
T-helper 1 cell differentiation -0.12 0.18 -10000 0 -0.6 1 1
IL2RA -0.15 0.25 -10000 0 -0.84 1 1
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
CASP3 -0.055 0.11 -10000 0 -0.28 2 2
E2F1 0.029 0 -10000 0 -10000 0 0
PPARG 0.012 0.051 -10000 0 -0.19 1 1
SLC3A2 -0.061 0.12 -10000 0 -10000 0 0
IRF4 0.025 0.001 -10000 0 -10000 0 0
PTGS2 -0.24 0.28 -10000 0 -0.7 3 3
CSF2 -0.25 0.28 -10000 0 -0.7 3 3
JunB/Fra1/NFAT1-c-4 -0.18 0.29 -10000 0 -0.64 4 4
IL4 -0.14 0.35 -10000 0 -1.4 1 1
IL5 -0.24 0.28 -10000 0 -0.7 3 3
IL2 -0.13 0.2 -10000 0 -0.57 2 2
IL3 -0.019 0.053 -10000 0 -10000 0 0
RNF128 -0.015 0.11 -10000 0 -0.4 1 1
NFATC1 -0.16 0.23 -10000 0 -0.52 4 4
CDK4 0.12 0.17 -10000 0 -10000 0 0
PTPRK -0.055 0.11 -10000 0 -10000 0 0
IL8 -0.29 0.3 -10000 0 -0.69 4 4
POU2F1 0.028 0.007 -10000 0 -10000 0 0
Stabilization and expansion of the E-cadherin adherens junction

Figure S32.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S32.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
adherens junction organization -0.017 0.062 -10000 0 -0.17 2 2
epithelial cell differentiation 0 0.075 -10000 0 -0.15 2 2
CYFIP2 0.023 0.006 -10000 0 -10000 0 0
ENAH -0.044 0.072 -10000 0 -0.21 1 1
EGFR -0.036 0.12 -10000 0 -0.27 3 3
EPHA2 0.023 0.006 -10000 0 -10000 0 0
MYO6 -0.017 0.084 0.16 2 -10000 0 2
CTNNB1 -0.018 0.11 -10000 0 -0.31 2 2
ABI1/Sra1/Nap1 0.035 0.04 -10000 0 -10000 0 0
AQP5 -0.037 0.12 -10000 0 -0.38 1 1
CTNND1 0.025 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 -0.016 0.083 0.16 2 -10000 0 2
regulation of calcium-dependent cell-cell adhesion -0.018 0.082 0.16 2 -10000 0 2
EGF -0.056 0.12 -10000 0 -0.24 5 5
NCKAP1 0.012 0.051 -10000 0 -0.19 1 1
AQP3 -0.027 0.07 -10000 0 -10000 0 0
cortical microtubule organization 0 0.075 -10000 0 -0.15 2 2
GO:0000145 -0.016 0.079 0.15 2 -10000 0 2
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.003 0.077 -10000 0 -0.15 2 2
MLLT4 0.025 0 -10000 0 -10000 0 0
ARF6/GDP -0.051 0.065 -10000 0 -0.26 1 1
ARF6 0.022 0.008 -10000 0 -10000 0 0
Ephrin A1/EPHA2/NCK1/GIT1 0.046 0.057 -10000 0 -0.16 1 1
mol:Ca2+ 0 0 -10000 0 -10000 0 0
VASP -0.017 0.066 0.16 1 -10000 0 1
PVRL2 0.025 0 -10000 0 -10000 0 0
ZYX -0.013 0.084 0.16 2 -10000 0 2
ARF6/GTP 0.048 0.058 -10000 0 -0.16 1 1
CDH1 -0.024 0.1 -10000 0 -0.23 3 3
EGFR/EGFR/EGF/EGF -0.075 0.11 -10000 0 -0.28 3 3
RhoA/GDP -0.007 0.089 -10000 0 -0.17 3 3
actin cytoskeleton organization -0.02 0.079 0.15 2 -10000 0 2
IGF-1R heterotetramer 0.025 0 -10000 0 -10000 0 0
GIT1 0.025 0 -10000 0 -10000 0 0
IGF1R 0.025 0 -10000 0 -10000 0 0
IGF1 0.012 0.051 -10000 0 -0.19 1 1
DIAPH1 0.021 0.095 -10000 0 -10000 0 0
Wnt receptor signaling pathway 0 0.075 0.15 2 -10000 0 2
RHOA 0.004 0.081 -10000 0 -0.31 1 1
RhoA/GTP -0.059 0.075 -10000 0 -0.23 2 2
CTNNA1 0.023 0.006 -10000 0 -10000 0 0
VCL -0.021 0.08 0.15 2 -10000 0 2
EFNA1 0.003 0.081 -10000 0 -0.31 1 1
LPP -0.03 0.068 0.16 1 -10000 0 1
Ephrin A1/EPHA2 -0.01 0.091 -10000 0 -0.21 2 2
SEC6/SEC8 -0.037 0.05 -10000 0 -10000 0 0
MGAT3 -0.019 0.083 0.16 2 -10000 0 2
HGF/MET -0.009 0.062 -10000 0 -10000 0 0
HGF 0.019 0.011 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.017 0.063 -10000 0 -0.18 2 2
actin cable formation 0.004 0.093 0.25 1 -10000 0 1
KIAA1543 -0.029 0.091 0.16 2 -10000 0 2
KIFC3 -0.036 0.075 0.16 1 -10000 0 1
NCK1 0.025 0 -10000 0 -10000 0 0
EXOC3 0.025 0 -10000 0 -10000 0 0
ACTN1 -0.028 0.07 0.17 1 -10000 0 1
NCK1/GIT1 0.037 0 -10000 0 -10000 0 0
mol:GDP 0 0.075 -10000 0 -0.15 2 2
EXOC4 0.019 0.011 -10000 0 -10000 0 0
STX4 -0.036 0.049 -10000 0 -0.15 2 2
PIP5K1C -0.017 0.084 0.16 2 -10000 0 2
LIMA1 0 0 -10000 0 -10000 0 0
ABI1 0.023 0.006 -10000 0 -10000 0 0
ROCK1 -0.036 0.097 0.17 1 -0.24 1 2
adherens junction assembly -0.038 0.14 0.25 1 -0.44 1 2
IGF-1R heterotetramer/IGF1 -0.006 0.081 -10000 0 -0.18 2 2
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0 -10000 0 -10000 0 0
MET 0.016 0.012 -10000 0 -10000 0 0
PLEKHA7 -0.011 0.082 0.16 2 -10000 0 2
mol:GTP 0.044 0.056 -10000 0 -0.16 1 1
establishment of epithelial cell apical/basal polarity -0.002 0.091 0.14 4 -10000 0 4
cortical actin cytoskeleton stabilization -0.017 0.062 -10000 0 -0.17 2 2
regulation of cell-cell adhesion -0.02 0.079 0.15 2 -10000 0 2
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.017 0.063 -10000 0 -0.18 2 2
E-cadherin signaling in the nascent adherens junction

Figure S33.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S33.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN -0.061 0.14 -9999 0 -0.34 3 3
KLHL20 -0.021 0.082 -9999 0 -0.22 1 1
CYFIP2 0.023 0.006 -9999 0 -10000 0 0
Rac1/GDP -0.04 0.095 -9999 0 -0.21 2 2
ENAH -0.043 0.12 -9999 0 -0.36 2 2
AP1M1 0.025 0 -9999 0 -10000 0 0
RAP1B 0.012 0.051 -9999 0 -0.19 1 1
RAP1A 0.003 0.081 -9999 0 -0.31 1 1
CTNNB1 -0.018 0.11 -9999 0 -0.31 2 2
CDC42/GTP -0.019 0.059 -9999 0 -10000 0 0
ABI1/Sra1/Nap1 -0.032 0.043 -9999 0 -0.15 1 1
E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.026 0.091 -9999 0 -0.16 3 3
RAPGEF1 -0.052 0.13 -9999 0 -0.3 3 3
CTNND1 0.025 0 -9999 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion -0.056 0.14 -9999 0 -0.34 3 3
CRK -0.049 0.12 -9999 0 -0.35 2 2
E-cadherin/gamma catenin/alpha catenin 0.012 0.06 -9999 0 -10000 0 0
alphaE/beta7 Integrin 0.015 0.054 -9999 0 -0.13 2 2
IQGAP1 0.025 0 -9999 0 -10000 0 0
NCKAP1 0.012 0.051 -9999 0 -0.19 1 1
Rap1/GTP/I-afadin 0.023 0.059 -9999 0 -0.16 1 1
DLG1 -0.062 0.14 -9999 0 -0.34 3 3
ChemicalAbstracts:7440-70-2 0 0 -9999 0 -10000 0 0
mol:PI-3-4-5-P3 -0.034 0.035 -9999 0 -10000 0 0
MLLT4 0.025 0 -9999 0 -10000 0 0
ARF6/GTP/NME1/Tiam1 0.033 0.022 -9999 0 -10000 0 0
PI3K -0.042 0.044 -9999 0 -10000 0 0
ARF6 0.022 0.008 -9999 0 -10000 0 0
mol:Ca2+ 0 0 -9999 0 -10000 0 0
E-cadherin/gamma catenin 0 0.062 -9999 0 -0.13 3 3
TIAM1 0.022 0.008 -9999 0 -10000 0 0
E-cadherin(dimer)/Ca2+ 0.003 0.077 -9999 0 -0.15 2 2
AKT1 -0.016 0.043 -9999 0 -10000 0 0
PIK3R1 0.023 0.006 -9999 0 -10000 0 0
CDH1 -0.024 0.1 -9999 0 -0.23 3 3
RhoA/GDP -0.037 0.096 -9999 0 -0.21 2 2
actin cytoskeleton organization -0.009 0.068 -9999 0 -0.16 1 1
CDC42/GDP -0.034 0.097 -9999 0 -0.21 2 2
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.003 0.023 -9999 0 -10000 0 0
ITGB7 0.012 0.051 -9999 0 -0.19 1 1
RAC1 0.019 0.011 -9999 0 -10000 0 0
E-cadherin/beta catenin/alpha catenin/p120 catenin 0.003 0.083 -9999 0 -0.16 2 2
E-cadherin/Ca2+/beta catenin/alpha catenin -0.005 0.07 -9999 0 -0.15 2 2
mol:GDP -0.049 0.1 -9999 0 -0.24 2 2
CDC42/GTP/IQGAP1 0.032 0.008 -9999 0 -10000 0 0
JUP 0.009 0.051 -9999 0 -0.19 1 1
p120 catenin/RhoA/GDP -0.038 0.1 -9999 0 -0.22 2 2
RAC1/GTP/IQGAP1 0.025 0.015 -9999 0 -10000 0 0
PIP5K1C/AP1M1 0.037 0 -9999 0 -10000 0 0
RHOA 0.004 0.081 -9999 0 -0.31 1 1
CDC42 0.023 0.006 -9999 0 -10000 0 0
CTNNA1 0.023 0.006 -9999 0 -10000 0 0
positive regulation of S phase of mitotic cell cycle -0.01 0.062 -9999 0 -0.14 1 1
NME1 0.023 0.006 -9999 0 -10000 0 0
clathrin coat assembly 0 0 -9999 0 -10000 0 0
TJP1 -0.061 0.14 -9999 0 -0.34 3 3
regulation of cell-cell adhesion -0.024 0.05 -9999 0 -10000 0 0
WASF2 -0.004 0.039 -9999 0 -10000 0 0
Rap1/GTP -0.023 0.063 -9999 0 -10000 0 0
E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.008 0.074 -9999 0 -10000 0 0
CCND1 -0.013 0.074 -9999 0 -0.18 1 1
VAV2 -0.086 0.19 -9999 0 -0.42 3 3
RAP1/GDP -0.017 0.085 -9999 0 -10000 0 0
adherens junction assembly -0.059 0.13 -9999 0 -0.33 3 3
homophilic cell adhesion 0 0 -9999 0 -10000 0 0
ABI1 0.023 0.006 -9999 0 -10000 0 0
PIP5K1C 0.025 0 -9999 0 -10000 0 0
regulation of heterotypic cell-cell adhesion -0.018 0.071 -9999 0 -10000 0 0
E-cadherin/beta catenin -0.025 0.065 -9999 0 -0.26 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
SRC -0.061 0.14 -9999 0 -0.34 3 3
PIK3CA 0.025 0 -9999 0 -10000 0 0
Rac1/GTP -0.068 0.096 -9999 0 -0.34 1 1
E-cadherin/beta catenin/alpha catenin -0.007 0.083 -9999 0 -0.18 2 2
ITGAE 0.01 0.051 -9999 0 -0.19 1 1
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.057 0.14 -9999 0 -0.35 3 3
TCGA08_retinoblastoma

Figure S34.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S34.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2B 0.013 0.027 -10000 0 -10000 0 0
CDKN2C -0.023 0.098 -10000 0 -0.22 3 3
CDKN2A 0.027 0.018 -10000 0 -10000 0 0
CCND2 0 0.048 0.13 1 -10000 0 1
RB1 -0.005 0.047 -10000 0 -0.14 1 1
CDK4 0.009 0.043 0.15 1 -10000 0 1
CDK6 0.001 0.056 0.15 1 -0.12 1 2
G1/S progression 0.005 0.047 0.14 1 -10000 0 1
EGFR-dependent Endothelin signaling events

Figure S35.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S35.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HRAS 0.025 0 -10000 0 -10000 0 0
EGFR -0.036 0.12 -10000 0 -0.27 3 3
EGF/EGFR -0.05 0.12 -10000 0 -0.23 4 4
EGF/EGFR dimer/SHC/GRB2/SOS1 -0.015 0.093 -10000 0 -0.2 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
EDNRA 0.004 0.081 -10000 0 -0.31 1 1
response to oxidative stress 0 0 -10000 0 -10000 0 0
EGF -0.056 0.12 -10000 0 -0.24 5 5
EGF/EGFR dimer/SHC -0.043 0.12 -10000 0 -0.26 3 3
mol:GDP -0.017 0.09 -10000 0 -0.19 2 2
mol:Ca2+ 0 0 -10000 0 -10000 0 0
EDN1 -0.009 0.093 -10000 0 -0.25 2 2
GRB2/SOS1 0.033 0.012 -10000 0 -10000 0 0
HRAS/GTP -0.022 0.08 -10000 0 -0.22 1 1
SHC1 0.023 0.006 -10000 0 -10000 0 0
HRAS/GDP -0.017 0.088 -10000 0 -0.22 1 1
FRAP1 -0.007 0.12 0.17 4 -0.22 1 5
EGF/EGFR dimer -0.067 0.13 -10000 0 -0.22 6 6
SOS1 0.025 0 -10000 0 -10000 0 0
GRB2 0.022 0.008 -10000 0 -10000 0 0
ETA receptor/Endothelin-1 -0.004 0.088 -10000 0 -0.18 3 3
Syndecan-4-mediated signaling events

Figure S36.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S36.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.015 0.071 -10000 0 -0.27 1 1
Syndecan-4/Syndesmos -0.056 0.14 -10000 0 -0.33 3 3
positive regulation of JNK cascade -0.098 0.18 -10000 0 -0.44 3 3
Syndecan-4/ADAM12 -0.058 0.14 -10000 0 -0.33 3 3
CCL5 -0.009 0.093 -10000 0 -0.25 2 2
Rac1/GDP 0.014 0.008 -10000 0 -10000 0 0
DNM2 0.004 0.081 -10000 0 -0.31 1 1
ITGA5 0.025 0 -10000 0 -10000 0 0
SDCBP 0.012 0.051 -10000 0 -0.19 1 1
PLG 0.005 0.054 -10000 0 -0.19 1 1
ADAM12 0.023 0.006 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
NUDT16L1 0.022 0.008 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
Syndecan-4/PKC alpha -0.031 0.018 -10000 0 -10000 0 0
Syndecan-4/Laminin alpha1 -0.044 0.14 -10000 0 -0.33 3 3
Syndecan-4/CXCL12/CXCR4 -0.1 0.19 -10000 0 -0.46 3 3
Syndecan-4/Laminin alpha3 -0.068 0.16 -10000 0 -0.37 3 3
MDK 0.003 0.081 -10000 0 -0.31 1 1
Syndecan-4/FZD7 -0.068 0.14 -10000 0 -0.33 3 3
Syndecan-4/Midkine -0.063 0.16 -10000 0 -0.37 3 3
FZD7 -0.001 0.07 -10000 0 -0.19 2 2
Syndecan-4/FGFR1/FGF -0.09 0.17 -10000 0 -0.35 4 4
THBS1 0.004 0.081 -10000 0 -0.31 1 1
integrin-mediated signaling pathway -0.054 0.14 -10000 0 -0.32 3 3
positive regulation of MAPKKK cascade -0.098 0.18 -10000 0 -0.44 3 3
Syndecan-4/TACI -0.058 0.14 -10000 0 -0.33 3 3
CXCR4 -0.051 0.13 -10000 0 -0.28 4 4
cell adhesion 0.028 0.053 0.16 2 -10000 0 2
Syndecan-4/Dynamin -0.059 0.14 -10000 0 -0.33 3 3
Syndecan-4/TSP1 -0.059 0.14 -10000 0 -0.33 3 3
Syndecan-4/GIPC -0.056 0.14 -10000 0 -0.33 3 3
Syndecan-4/RANTES -0.068 0.16 -10000 0 -0.37 3 3
ITGB1 0.023 0.006 -10000 0 -10000 0 0
LAMA1 0.022 0.008 -10000 0 -10000 0 0
LAMA3 -0.011 0.092 -10000 0 -0.25 2 2
RAC1 0.019 0.011 -10000 0 -10000 0 0
PRKCA 0.1 0.28 0.83 2 -10000 0 2
Syndecan-4/alpha-Actinin -0.056 0.14 -10000 0 -0.33 3 3
TFPI 0.004 0.081 -10000 0 -0.31 1 1
F2 0.013 0.022 -10000 0 -10000 0 0
alpha5/beta1 Integrin 0.035 0.009 -10000 0 -10000 0 0
positive regulation of cell adhesion -0.061 0.15 -10000 0 -0.36 3 3
ACTN1 0.022 0.008 -10000 0 -10000 0 0
TNC 0.023 0.006 -10000 0 -10000 0 0
Syndecan-4/CXCL12 -0.08 0.18 -10000 0 -0.44 3 3
FGF6 -0.038 0.13 -10000 0 -0.31 3 3
RHOA 0.004 0.081 -10000 0 -0.31 1 1
CXCL12 -0.043 0.12 -10000 0 -0.25 4 4
TNFRSF13B 0.023 0.006 -10000 0 -10000 0 0
FGF2 -0.017 0.11 -10000 0 -0.31 2 2
FGFR1 0.012 0.051 -10000 0 -0.19 1 1
Syndecan-4/PI-4-5-P2 -0.065 0.13 -10000 0 -0.33 3 3
mol:GDP 0 0 -10000 0 -10000 0 0
FN1 0.006 0.062 -10000 0 -0.22 1 1
cell migration -0.013 0.014 -10000 0 -10000 0 0
PRKCD 0.018 0.022 -10000 0 -10000 0 0
vasculogenesis -0.057 0.14 -10000 0 -0.32 3 3
SDC4 -0.057 0.14 -10000 0 -0.34 3 3
Syndecan-4/Tenascin C -0.056 0.14 -10000 0 -0.33 3 3
Syndecan-4/PI-4-5-P2/PKC alpha -0.025 0.015 -10000 0 -10000 0 0
Syndecan-4/Syntenin -0.061 0.14 -10000 0 -0.33 3 3
MMP9 -0.068 0.13 -10000 0 -0.26 5 5
Rac1/GTP 0.028 0.053 0.17 2 -10000 0 2
cytoskeleton organization -0.054 0.14 -10000 0 -0.32 3 3
GIPC1 0.025 0 -10000 0 -10000 0 0
Syndecan-4/TFPI -0.064 0.14 -10000 0 -0.33 3 3
Plasma membrane estrogen receptor signaling

Figure S37.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S37.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 0.026 0.071 -10000 0 -0.15 2 2
ER alpha/Gai/GDP/Gbeta gamma -0.015 0.09 -10000 0 -0.26 1 1
AKT1 -0.058 0.21 -10000 0 -0.62 2 2
PIK3CA 0.025 0 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1/Src/PI3K -0.05 0.22 -10000 0 -0.63 2 2
mol:Ca2+ -0.055 0.093 -10000 0 -0.22 3 3
IGF1R 0.025 0 -10000 0 -10000 0 0
E2/ER alpha (dimer)/Striatin -0.032 0.098 -10000 0 -0.18 5 5
SHC1 0.023 0.006 -10000 0 -10000 0 0
apoptosis 0.055 0.21 0.6 2 -10000 0 2
RhoA/GTP -0.017 0.085 -10000 0 -0.27 1 1
E2/ER alpha (dimer)/PELP1/Src/p130 Cas -0.024 0.13 -10000 0 -0.29 1 1
regulation of stress fiber formation 0.027 0.085 0.22 1 -0.14 2 3
E2/ERA-ERB (dimer) 0.003 0.069 -10000 0 -0.18 2 2
KRAS 0.025 0 -10000 0 -10000 0 0
G13/GTP 0.004 0.062 -10000 0 -0.16 2 2
pseudopodium formation -0.027 0.085 0.14 2 -0.22 1 3
E2/ER alpha (dimer)/PELP1 -0.003 0.074 -10000 0 -0.15 3 3
GRB2 0.022 0.008 -10000 0 -10000 0 0
GNG2 0.022 0.008 -10000 0 -10000 0 0
GNAO1 0.023 0.006 -10000 0 -10000 0 0
HRAS 0.025 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
mol:NO -0.036 0.15 -10000 0 -0.33 3 3
E2/ER beta (dimer) 0.016 0.006 -10000 0 -10000 0 0
mol:GDP -0.032 0.1 -10000 0 -0.29 2 2
mol:NADP -0.036 0.15 -10000 0 -0.33 3 3
PIK3R1 0.023 0.006 -10000 0 -10000 0 0
mol:IP3 -0.057 0.096 -10000 0 -0.23 3 3
IGF-1R heterotetramer 0.025 0 -10000 0 -10000 0 0
PLCB1 -0.05 0.093 -10000 0 -0.2 4 4
PLCB2 -0.042 0.085 -10000 0 -0.23 2 2
IGF1 0.012 0.051 -10000 0 -0.19 1 1
mol:L-citrulline -0.036 0.15 -10000 0 -0.33 3 3
RHOA 0.004 0.081 -10000 0 -0.31 1 1
Gai/GDP 0.013 0.043 -10000 0 -10000 0 0
JNK cascade 0.016 0.006 -10000 0 -10000 0 0
BCAR1 0.023 0.006 -10000 0 -10000 0 0
ESR2 0.022 0.008 -10000 0 -10000 0 0
GNAQ 0 0 -10000 0 -10000 0 0
ESR1 -0.017 0.11 -10000 0 -0.31 2 2
Gq family/GDP/Gbeta gamma -0.016 0.076 -10000 0 -0.25 1 1
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 0.009 0.069 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1/Src/p52 SHC -0.009 0.12 -10000 0 -0.29 1 1
GNAZ 0.025 0 -10000 0 -10000 0 0
E2/ER alpha (dimer) -0.01 0.075 -10000 0 -0.21 2 2
STRN -0.038 0.13 -10000 0 -0.31 3 3
GNAL 0.022 0.008 -10000 0 -10000 0 0
PELP1 0.01 0.051 -10000 0 -0.19 1 1
MAPK11 -0.002 0.045 -10000 0 -0.18 1 1
GNAI2 0.025 0 -10000 0 -10000 0 0
GNAI3 0.023 0.006 -10000 0 -10000 0 0
GNAI1 -0.002 0.08 -10000 0 -0.31 1 1
HBEGF -0.033 0.13 -10000 0 -0.29 2 2
cAMP biosynthetic process 0.002 0.056 -10000 0 -0.14 2 2
SRC -0.035 0.11 -10000 0 -0.29 1 1
PI3K 0.035 0.009 -10000 0 -10000 0 0
GNB1 0.023 0.006 -10000 0 -10000 0 0
G13/GDP/Gbeta gamma -0.007 0.1 -10000 0 -0.26 2 2
SOS1 0.025 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1 -0.042 0.082 -10000 0 -0.25 1 1
Gs family/GTP 0.007 0.059 -10000 0 -0.14 2 2
EntrezGene:2778 0 0 -10000 0 -10000 0 0
RAS family/GTP 0.032 0.051 -10000 0 -0.16 1 1
vasodilation -0.034 0.15 -10000 0 -0.32 3 3
mol:DAG -0.057 0.096 -10000 0 -0.23 3 3
Gs family/GDP/Gbeta gamma -0.02 0.094 -10000 0 -0.26 2 2
MSN -0.029 0.089 0.14 2 -0.24 1 3
Gq family/GTP -0.034 0.088 -10000 0 -0.24 2 2
mol:PI-3-4-5-P3 -0.047 0.21 -10000 0 -0.61 2 2
NRAS 0.003 0.081 -10000 0 -0.31 1 1
mol:E2 0 0 -10000 0 -10000 0 0
cell adhesion 0.034 0.15 0.32 3 -10000 0 3
GRB2/SOS1 0.033 0.012 -10000 0 -10000 0 0
RhoA/GDP -0.021 0.12 -10000 0 -0.25 3 3
NOS3 -0.038 0.16 -10000 0 -0.34 3 3
GNA11 -0.001 0.07 -10000 0 -0.19 2 2
MAPKKK cascade -0.067 0.17 -10000 0 -0.44 2 2
E2/ER alpha (dimer)/PELP1/Src -0.021 0.13 -10000 0 -0.3 1 1
ruffle organization -0.027 0.085 0.14 2 -0.22 1 3
ROCK2 -0.028 0.095 0.16 2 -0.26 1 3
GNA14 0.003 0.081 -10000 0 -0.31 1 1
GNA15 0.025 0 -10000 0 -10000 0 0
GNA13 0.022 0.008 -10000 0 -10000 0 0
MMP9 -0.053 0.13 -10000 0 -0.32 2 2
MMP2 -0.012 0.13 0.25 1 -0.28 1 2
Visual signal transduction: Rods

Figure S38.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S38.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:K + 0.004 0.081 -9999 0 -0.31 1 1
GNAT1/GTP 0.019 0 -9999 0 -10000 0 0
Metarhodopsin II/Arrestin 0.019 0.051 -9999 0 -0.18 1 1
PDE6G/GNAT1/GTP 0.03 0.011 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
absorption of light 0 0 -9999 0 -10000 0 0
GNAT1 0.025 0 -9999 0 -10000 0 0
GRK1 0 0 -9999 0 -10000 0 0
CNG Channel 0.037 0.024 -9999 0 -10000 0 0
mol:Na + 0.016 0.074 -9999 0 -0.2 1 1
mol:ADP 0 0 -9999 0 -10000 0 0
RGS9-1/Gbeta5/R9AP -0.047 0.1 -9999 0 -0.18 5 5
mol:GDP 0 0 -9999 0 -10000 0 0
cGMP/CNG Channel 0.025 0.08 -9999 0 -0.21 1 1
CNGB1 0.023 0.006 -9999 0 -10000 0 0
RDH5 -0.03 0.12 -9999 0 -0.27 3 3
SAG 0.003 0.081 -9999 0 -0.31 1 1
mol:Ca2+ -0.04 0.089 -9999 0 -0.32 1 1
Na + (4 Units) 0.002 0.094 -9999 0 -0.32 1 1
RGS9 -0.033 0.12 -9999 0 -0.27 3 3
GNB1/GNGT1 -0.056 0.1 -9999 0 -0.18 6 6
GNAT1/GDP -0.033 0.094 -9999 0 -0.15 5 5
GUCY2D 0.023 0.006 -9999 0 -10000 0 0
GNGT1 -0.093 0.14 -9999 0 -0.27 6 6
GUCY2F -0.012 0.092 -9999 0 -0.25 2 2
GNB5 -0.017 0.11 -9999 0 -0.31 2 2
mol:GMP (4 units) 0.019 0.009 -9999 0 -10000 0 0
mol:11-cis-retinal -0.03 0.12 -9999 0 -0.27 3 3
mol:cGMP 0.027 0.073 -9999 0 -0.22 1 1
GNB1 0.023 0.006 -9999 0 -10000 0 0
Rhodopsin -0.004 0.088 -9999 0 -0.18 3 3
SLC24A1 0.004 0.081 -9999 0 -0.31 1 1
CNGA1 0.012 0.051 -9999 0 -0.19 1 1
Metarhodopsin II 0.016 0 -9999 0 -10000 0 0
mol:Ca ++ 0 0 -9999 0 -10000 0 0
GC1/GCAP Family 0.055 0.035 -9999 0 -10000 0 0
RGS9BP -0.03 0.12 -9999 0 -0.27 3 3
Metarhodopsin II/Transducin -0.049 0.088 -9999 0 -0.2 4 4
GCAP Family/Ca ++ 0.039 0.034 -9999 0 -10000 0 0
PDE6A/B 0.033 0.012 -9999 0 -10000 0 0
mol:Pi -0.047 0.1 -9999 0 -0.18 5 5
mol:all-trans-retinal 0 0 -9999 0 -10000 0 0
Transducin -0.036 0.082 -9999 0 -0.16 4 4
PDE6B 0.023 0.006 -9999 0 -10000 0 0
PDE6A 0.023 0.006 -9999 0 -10000 0 0
PDE6G 0.022 0.008 -9999 0 -10000 0 0
RHO 0.025 0 -9999 0 -10000 0 0
PDE6 -0.033 0.097 -9999 0 -10000 0 0
GUCA1A 0.022 0.011 -9999 0 -10000 0 0
GC2/GCAP Family 0.034 0.082 -9999 0 -0.24 1 1
GUCA1C 0.012 0.051 -9999 0 -0.19 1 1
GUCA1B 0.025 0 -9999 0 -10000 0 0
Class IB PI3K non-lipid kinase events

Figure S39.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S39.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
cAMP biosynthetic process -0.01 0.051 0.19 1 -10000 0 1
PI3K Class IB/PDE3B 0.01 0.051 -10000 0 -0.19 1 1
PDE3B 0.01 0.051 -10000 0 -0.19 1 1
Signaling events mediated by Stem cell factor receptor (c-Kit)

Figure S40.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S40.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K1 -0.051 0.17 -10000 0 -0.45 2 2
CRKL -0.05 0.18 -10000 0 -0.48 2 2
HRAS -0.029 0.15 -10000 0 -0.51 1 1
mol:PIP3 -0.03 0.18 -10000 0 -0.44 2 2
SPRED1 0.004 0.081 -10000 0 -0.31 1 1
SPRED2 0.012 0.051 -10000 0 -0.19 1 1
GAB1 -0.049 0.19 -10000 0 -0.5 2 2
FOXO3 -0.026 0.22 0.3 1 -0.42 3 4
AKT1 -0.029 0.23 0.31 1 -0.45 3 4
BAD -0.037 0.22 0.29 1 -0.42 3 4
megakaryocyte differentiation -0.067 0.22 -10000 0 -0.6 2 2
GSK3B -0.029 0.22 0.29 1 -0.42 3 4
RAF1 -0.027 0.13 -10000 0 -0.41 1 1
SHC1 0.023 0.006 -10000 0 -10000 0 0
STAT3 -0.065 0.18 -10000 0 -0.5 2 2
STAT1 -0.14 0.4 -10000 0 -1.1 2 2
HRAS/SPRED1 -0.024 0.13 -10000 0 -0.41 1 1
cell proliferation -0.057 0.18 -10000 0 -0.49 2 2
PIK3CA 0.025 0.001 -10000 0 -10000 0 0
TEC 0.004 0.081 -10000 0 -0.31 1 1
RPS6KB1 -0.035 0.2 0.24 1 -0.5 2 3
HRAS/SPRED2 -0.021 0.13 -10000 0 -0.41 1 1
LYN/TEC/p62DOK -0.03 0.19 -10000 0 -0.48 2 2
MAPK3 0.004 0.13 0.34 1 -0.28 1 2
STAP1 -0.046 0.19 -10000 0 -0.49 2 2
GRAP2 0.023 0.006 -10000 0 -10000 0 0
JAK2 -0.14 0.32 -10000 0 -0.94 2 2
STAT1 (dimer) -0.13 0.39 -10000 0 -1.1 2 2
mol:Gleevec 0 0.007 -10000 0 -10000 0 0
GRB2/SOCS1/VAV1 -0.042 0.18 -10000 0 -0.45 2 2
actin filament polymerization -0.045 0.18 -10000 0 -0.48 2 2
LYN 0.025 0 -10000 0 -10000 0 0
STAP1/STAT5A (dimer) -0.085 0.24 -10000 0 -0.67 2 2
PIK3R1 0.024 0.006 -10000 0 -10000 0 0
CBL/CRKL/GRB2 -0.025 0.16 -10000 0 -0.48 1 1
PI3K -0.021 0.21 0.25 1 -0.48 2 3
PTEN 0.025 0 -10000 0 -10000 0 0
SCF/KIT/EPO/EPOR -0.16 0.44 -10000 0 -1.3 2 2
MAPK8 -0.059 0.18 -10000 0 -0.5 2 2
STAT3 (dimer) -0.064 0.18 -10000 0 -0.49 2 2
positive regulation of transcription 0.008 0.11 0.32 1 -0.23 1 2
mol:GDP -0.042 0.16 -10000 0 -0.55 1 1
PIK3C2B -0.055 0.18 -10000 0 -0.5 2 2
CBL/CRKL -0.039 0.17 -10000 0 -0.45 2 2
FER -0.055 0.18 -10000 0 -0.5 2 2
SH2B3 -0.046 0.19 -10000 0 -0.49 2 2
PDPK1 -0.01 0.19 0.34 1 -0.41 2 3
SNAI2 -0.061 0.22 -10000 0 -0.59 2 2
positive regulation of cell proliferation -0.08 0.31 -10000 0 -0.83 2 2
KITLG -0.046 0.13 -10000 0 -0.26 4 4
cell motility -0.08 0.31 -10000 0 -0.83 2 2
PTPN6 0.003 0.081 -10000 0 -0.3 1 1
EPOR -0.021 0.14 -10000 0 -10000 0 0
STAT5A (dimer) -0.077 0.25 -10000 0 -0.68 2 2
SOCS1 0.001 0.08 -10000 0 -0.31 1 1
cell migration 0.052 0.18 0.49 2 -10000 0 2
SOS1 0.025 0 -10000 0 -10000 0 0
EPO 0.01 0.021 -10000 0 -10000 0 0
VAV1 0.004 0.081 -10000 0 -0.31 1 1
GRB10 -0.066 0.18 -10000 0 -0.5 2 2
PTPN11 0.021 0.016 -10000 0 -10000 0 0
SCF/KIT -0.047 0.2 -10000 0 -0.52 2 2
GO:0007205 0.002 0.009 -10000 0 -10000 0 0
MAP2K1 -0.001 0.14 0.36 1 -0.32 1 2
CBL 0.025 0 -10000 0 -10000 0 0
KIT -0.14 0.41 -10000 0 -1.2 2 2
MAP2K2 -0.001 0.14 0.36 1 -0.32 1 2
SHC/Grb2/SOS1 -0.017 0.17 -10000 0 -0.4 2 2
STAT5A -0.08 0.26 -10000 0 -0.7 2 2
GRB2 0.022 0.008 -10000 0 -10000 0 0
response to radiation -0.059 0.21 -10000 0 -0.58 2 2
SHC/GRAP2 0.035 0.009 -10000 0 -10000 0 0
PTPRO -0.069 0.22 -10000 0 -0.62 2 2
SH2B2 -0.046 0.19 -10000 0 -0.49 2 2
DOK1 0.025 0 -10000 0 -10000 0 0
MATK -0.054 0.19 -10000 0 -0.5 2 2
CREBBP 0.004 0.064 -10000 0 -0.17 1 1
BCL2 -0.1 0.35 -10000 0 -0.94 2 2
LPA4-mediated signaling events

Figure S41.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S41.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ADCY4 -0.024 0.046 -10000 0 -0.14 2 2
ADCY5 -0.014 0.023 -10000 0 -0.1 1 1
ADCY6 -0.008 0.002 -10000 0 -10000 0 0
ADCY7 -0.008 0.003 -10000 0 -10000 0 0
ADCY1 -0.016 0.042 -10000 0 -0.18 1 1
ADCY2 -0.029 0.056 -10000 0 -0.18 2 2
ADCY3 -0.008 0.002 -10000 0 -10000 0 0
ADCY8 -0.014 0.023 -10000 0 -0.1 1 1
PRKCE -0.005 0.001 -10000 0 -10000 0 0
ADCY9 -0.007 0.003 -10000 0 -10000 0 0
mol:DAG 0 0 -10000 0 -10000 0 0
cAMP biosynthetic process 0.003 0.068 0.15 1 -10000 0 1
ErbB2/ErbB3 signaling events

Figure S42.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S42.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
USP8 -0.009 0.006 -10000 0 -10000 0 0
RAS family/GTP -0.004 0.11 -10000 0 -0.36 1 1
NFATC4 -0.049 0.085 -10000 0 -0.24 2 2
ERBB2IP 0.024 0.007 -10000 0 -10000 0 0
HSP90 (dimer) 0 0 -10000 0 -10000 0 0
mammary gland morphogenesis -0.03 0.092 -10000 0 -0.23 2 2
JUN 0.006 0.062 -10000 0 -10000 0 0
HRAS 0.025 0.001 -10000 0 -10000 0 0
DOCK7 -0.054 0.076 -10000 0 -0.28 1 1
ErbB2/ErbB3/neuregulin 1 beta/SHC 0.001 0.095 -10000 0 -0.23 2 2
AKT1 -0.006 0.005 -10000 0 -10000 0 0
BAD -0.019 0.041 -10000 0 -0.18 1 1
MAPK10 -0.014 0.086 0.18 1 -0.2 1 2
mol:GTP 0 0.001 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta -0.032 0.099 -10000 0 -0.25 2 2
RAF1 -0.011 0.12 0.26 1 -0.34 1 2
ErbB2/ErbB3/neuregulin 2 -0.001 0.059 -10000 0 -0.18 1 1
STAT3 -0.03 0.21 -10000 0 -0.84 1 1
cell migration -0.016 0.088 0.19 1 -0.18 1 2
mol:PI-3-4-5-P3 -0.001 0.002 -10000 0 -10000 0 0
cell proliferation -0.019 0.15 -10000 0 -10000 0 0
FOS -0.037 0.17 -10000 0 -0.43 2 2
NRAS 0.003 0.081 -10000 0 -0.31 1 1
mol:Ca2+ -0.03 0.092 -10000 0 -0.23 2 2
MAPK3 -0.013 0.13 -10000 0 -10000 0 0
MAPK1 -0.01 0.13 -10000 0 -10000 0 0
JAK2 -0.043 0.056 -10000 0 -10000 0 0
NF2 0.006 0.008 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 -0.018 0.11 -10000 0 -0.43 1 1
NRG1 -0.019 0.11 -10000 0 -0.31 2 2
GRB2/SOS1 0.033 0.012 -10000 0 -10000 0 0
MAPK8 -0.038 0.11 -10000 0 -0.25 3 3
MAPK9 -0.012 0.08 0.18 1 -0.16 1 2
ERBB2 -0.021 0.006 -10000 0 -10000 0 0
ERBB3 0.002 0.081 -10000 0 -0.31 1 1
SHC1 0.023 0.006 -10000 0 -10000 0 0
RAC1 0.019 0.011 -10000 0 -10000 0 0
apoptosis 0.016 0.041 0.17 1 -10000 0 1
STAT3 (dimer) -0.028 0.2 -10000 0 -0.82 1 1
RNF41 -0.021 0.038 -10000 0 -0.17 1 1
FRAP1 -0.009 0.004 -10000 0 -10000 0 0
RAC1-CDC42/GTP -0.034 0.058 -10000 0 -0.22 1 1
ErbB2/ErbB2/HSP90 (dimer) -0.016 0.005 -10000 0 -10000 0 0
CHRNA1 -0.005 0.11 -10000 0 -10000 0 0
myelination -0.049 0.082 -10000 0 -0.23 2 2
PPP3CB -0.052 0.072 -10000 0 -0.26 1 1
KRAS 0.025 0.001 -10000 0 -10000 0 0
RAC1-CDC42/GDP -0.006 0.1 -10000 0 -0.38 1 1
NRG2 0.01 0.051 -10000 0 -0.19 1 1
mol:GDP -0.018 0.1 -10000 0 -0.42 1 1
SOS1 0.025 0 -10000 0 -10000 0 0
MAP2K2 -0.018 0.12 0.26 1 -0.32 1 2
SRC 0.025 0 -10000 0 -10000 0 0
mol:cAMP -0.001 0.001 -10000 0 -10000 0 0
PTPN11 -0.054 0.076 -10000 0 -0.28 1 1
MAP2K1 -0.017 0.13 -10000 0 -10000 0 0
heart morphogenesis -0.03 0.092 -10000 0 -0.23 2 2
RAS family/GDP 0.006 0.12 -10000 0 -0.37 1 1
GRB2 0.022 0.008 -10000 0 -10000 0 0
PRKACA 0.01 0.009 -10000 0 -10000 0 0
CHRNE 0.005 0.015 -10000 0 -10000 0 0
HSP90AA1 0 0 -10000 0 -10000 0 0
activation of caspase activity 0.006 0.005 -10000 0 -10000 0 0
nervous system development -0.03 0.092 -10000 0 -0.23 2 2
CDC42 0.023 0.006 -10000 0 -10000 0 0
Regulation of nuclear SMAD2/3 signaling

Figure S43.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S43.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.022 0.01 -10000 0 -10000 0 0
HSPA8 0.004 0.081 -10000 0 -0.31 1 1
SMAD3/SMAD4/ER alpha 0.023 0.078 -10000 0 -0.18 1 1
AKT1 0.021 0.013 -10000 0 -10000 0 0
GSC -0.038 0.12 -10000 0 -10000 0 0
NKX2-5 0.019 0.021 -10000 0 -10000 0 0
muscle cell differentiation -0.002 0.089 -10000 0 -10000 0 0
SMAD2-3/SMAD4/SP1 0.059 0.11 -10000 0 -0.3 1 1
SMAD4 0.021 0.042 -10000 0 -10000 0 0
CBFB 0.023 0.006 -10000 0 -10000 0 0
SAP18 0.025 0 -10000 0 -10000 0 0
Cbp/p300/MSG1 0.033 0.04 -10000 0 -10000 0 0
SMAD3/SMAD4/VDR 0.036 0.078 -10000 0 -10000 0 0
MYC 0.002 0.081 -10000 0 -0.31 1 1
CDKN2B -0.031 0.16 -10000 0 -0.49 1 1
AP1 -0.013 0.097 -10000 0 -0.24 1 1
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 0.002 0.062 -10000 0 -10000 0 0
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 0.019 0.015 -10000 0 -10000 0 0
SP3 0.026 0 -10000 0 -10000 0 0
CREB1 0.025 0 -10000 0 -10000 0 0
FOXH1 0.001 0.082 -10000 0 -0.3 1 1
SMAD3/SMAD4/GR 0.039 0.053 -10000 0 -10000 0 0
GATA3 0.015 0.05 -10000 0 -0.18 1 1
SKI/SIN3/HDAC complex/NCoR1 -0.012 0.12 -10000 0 -0.46 1 1
MEF2C/TIF2 -0.003 0.095 -10000 0 -0.32 1 1
endothelial cell migration -0.011 0.037 -10000 0 -10000 0 0
MAX 0.021 0.009 -10000 0 -10000 0 0
RBBP7 0.025 0 -10000 0 -10000 0 0
RBBP4 0.003 0.081 -10000 0 -0.31 1 1
RUNX2 0.025 0 -10000 0 -10000 0 0
RUNX3 -0.045 0.12 -10000 0 -0.25 4 4
RUNX1 0.022 0.008 -10000 0 -10000 0 0
CTBP1 0.023 0.006 -10000 0 -10000 0 0
NR3C1 0.023 0.007 -10000 0 -10000 0 0
VDR -0.001 0.07 -10000 0 -0.19 2 2
CDKN1A -0.047 0.28 -10000 0 -1.1 1 1
KAT2B 0 0.001 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1 0.032 0.078 -10000 0 -0.18 1 1
DCP1A 0.025 0 -10000 0 -10000 0 0
SKI 0.024 0.006 -10000 0 -10000 0 0
SERPINE1 0.011 0.037 -10000 0 -10000 0 0
SMAD3/SMAD4/ATF2 0.045 0.052 -10000 0 -10000 0 0
SMAD3/SMAD4/ATF3 0.014 0.1 -10000 0 -0.24 2 2
SAP30 0.024 0.006 -10000 0 -10000 0 0
Cbp/p300/PIAS3 0.039 0.024 -10000 0 -10000 0 0
JUN -0.023 0.089 -10000 0 -0.24 1 1
SMAD3/SMAD4/IRF7 0.049 0.053 -10000 0 -10000 0 0
TFE3 0.026 0.012 -10000 0 -10000 0 0
COL1A2 -0.035 0.2 -10000 0 -0.81 1 1
mesenchymal cell differentiation -0.045 0.052 -10000 0 -10000 0 0
DLX1 0.01 0.051 -10000 0 -0.19 1 1
TCF3 0.023 0.006 -10000 0 -10000 0 0
FOS -0.039 0.12 -10000 0 -0.28 3 3
SMAD3/SMAD4/Max 0.039 0.053 -10000 0 -10000 0 0
Cbp/p300/SNIP1 0.044 0.017 -10000 0 -10000 0 0
ZBTB17 0.022 0.006 -10000 0 -10000 0 0
LAMC1 0.009 0.036 -10000 0 -10000 0 0
TGIF2/HDAC complex/SMAD3/SMAD4 0.031 0.068 -10000 0 -10000 0 0
IRF7 0.027 0 -10000 0 -10000 0 0
ESR1 0.001 0.081 -10000 0 -0.31 1 1
HNF4A 0.025 0 -10000 0 -10000 0 0
MEF2C -0.018 0.093 -10000 0 -0.34 1 1
SMAD2-3/SMAD4 0.048 0.059 -10000 0 -10000 0 0
Cbp/p300/Src-1 0.043 0.017 -10000 0 -10000 0 0
IGHV3OR16-13 -0.001 0.019 -10000 0 -10000 0 0
TGIF2/HDAC complex 0.004 0.081 -10000 0 -0.31 1 1
CREBBP 0.021 0.008 -10000 0 -10000 0 0
SKIL 0.004 0.081 -10000 0 -0.31 1 1
HDAC1 0.024 0.006 -10000 0 -10000 0 0
HDAC2 0.025 0 -10000 0 -10000 0 0
SNIP1 0.024 0.006 -10000 0 -10000 0 0
GCN5L2 0.021 0.008 -10000 0 -10000 0 0
SMAD3/SMAD4/TFE3 0.053 0.054 -10000 0 -10000 0 0
MSG1/HSC70 0.012 0.07 -10000 0 -0.17 2 2
SMAD2 0.023 0.021 -10000 0 -10000 0 0
SMAD3 0.016 0.041 -10000 0 -10000 0 0
SMAD3/E2F4-5/DP1/p107/SMAD4 0 0.066 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4 0.007 0.067 0.18 1 -0.18 1 2
NCOR1 0.024 0.006 -10000 0 -10000 0 0
NCOA2 0.025 0 -10000 0 -10000 0 0
NCOA1 0.025 0 -10000 0 -10000 0 0
MYOD/E2A 0.022 0.04 -10000 0 -0.13 1 1
SMAD2-3/SMAD4/SP1/MIZ-1 0.062 0.1 -10000 0 -0.28 1 1
IFNB1 0.007 0.036 -10000 0 -10000 0 0
SMAD3/SMAD4/MEF2C 0.011 0.11 -10000 0 -0.34 1 1
CITED1 0.012 0.051 -10000 0 -0.19 1 1
SMAD2-3/SMAD4/ARC105 0.047 0.053 -10000 0 -10000 0 0
RBL1 0.004 0.081 -10000 0 -0.31 1 1
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB 0.02 0.024 -10000 0 -10000 0 0
RUNX1-3/PEBPB2 -0.01 0.082 -10000 0 -0.18 2 2
SMAD7 -0.003 0.089 -10000 0 -10000 0 0
MYC/MIZ-1 0.016 0.061 -10000 0 -0.22 1 1
SMAD3/SMAD4 0.014 0.048 -10000 0 -10000 0 0
IL10 0.003 0.039 -10000 0 -10000 0 0
PIASy/HDAC complex 0.026 0.002 -10000 0 -10000 0 0
PIAS3 0.023 0.006 -10000 0 -10000 0 0
CDK2 0.025 0.001 -10000 0 -10000 0 0
IL5 0.003 0.039 -10000 0 -10000 0 0
CDK4 0.024 0.002 -10000 0 -10000 0 0
PIAS4 0.026 0.002 -10000 0 -10000 0 0
ATF3 -0.018 0.11 -10000 0 -0.31 2 2
SMAD3/SMAD4/SP1 0.042 0.11 -10000 0 -0.34 1 1
FOXG1 0 0.004 -10000 0 -10000 0 0
FOXO3 0.006 0.006 -10000 0 -10000 0 0
FOXO1 0.006 0.006 -10000 0 -10000 0 0
FOXO4 0.006 0.006 -10000 0 -10000 0 0
heart looping -0.018 0.093 -10000 0 -0.34 1 1
CEBPB 0.026 0 -10000 0 -10000 0 0
SMAD3/SMAD4/DLX1 0.03 0.065 -10000 0 -10000 0 0
MYOD1 0.01 0.051 -10000 0 -0.19 1 1
SMAD3/SMAD4/HNF4 0.045 0.052 -10000 0 -10000 0 0
SMAD3/SMAD4/GATA3 0.044 0.061 -10000 0 -10000 0 0
SnoN/SIN3/HDAC complex/NCoR1 0.004 0.081 -10000 0 -0.31 1 1
SMAD3/SMAD4/RUNX1-3/PEBPB2 -0.005 0.09 -10000 0 -0.23 1 1
SMAD3/SMAD4/SP1-3 0.064 0.099 -10000 0 -0.3 1 1
MED15 0 0 -10000 0 -10000 0 0
SP1 0.017 0.057 -10000 0 -0.2 1 1
SIN3B 0.025 0 -10000 0 -10000 0 0
SIN3A 0.025 0 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/NKX2-5 0.04 0.089 -10000 0 -0.2 1 1
ITGB5 0.003 0.077 -10000 0 -0.28 1 1
TGIF/SIN3/HDAC complex/CtBP -0.007 0.074 -10000 0 -0.25 1 1
SMAD3/SMAD4/AR 0.045 0.052 -10000 0 -10000 0 0
AR 0.025 0 -10000 0 -10000 0 0
negative regulation of cell growth -0.012 0.083 -10000 0 -10000 0 0
SMAD3/SMAD4/MYOD 0.03 0.061 -10000 0 -10000 0 0
E2F5 0.004 0.081 -10000 0 -0.31 1 1
E2F4 0.023 0.006 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/SMIF 0.056 0.076 -10000 0 -10000 0 0
SMAD2-3/SMAD4/FOXO1-3a-4 0.019 0.031 -10000 0 -10000 0 0
TFDP1 0.025 0 -10000 0 -10000 0 0
SMAD3/SMAD4/AP1 0.002 0.11 -10000 0 -0.24 1 1
SMAD3/SMAD4/RUNX2 0.045 0.052 -10000 0 -10000 0 0
TGIF2 0.004 0.081 -10000 0 -0.31 1 1
TGIF1 0 0 -10000 0 -10000 0 0
ATF2 0.025 0 -10000 0 -10000 0 0
Coregulation of Androgen receptor activity

Figure S44.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S44.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NRIP1 0.023 0.009 -9999 0 -10000 0 0
SVIL 0.004 0.081 -9999 0 -0.31 1 1
ZNF318 0.023 0 -9999 0 -10000 0 0
JMJD2C 0.028 0.007 -9999 0 -10000 0 0
T-DHT/AR/Ubc9 0.025 0.033 -9999 0 -10000 0 0
CARM1 0.025 0 -9999 0 -10000 0 0
PRDX1 0.023 0.006 -9999 0 -10000 0 0
PELP1 0.01 0.051 -9999 0 -0.19 1 1
CTNNB1 -0.017 0.11 -9999 0 -0.31 2 2
AKT1 0.021 0.008 -9999 0 -10000 0 0
PTK2B 0.024 0.006 -9999 0 -10000 0 0
MED1 -0.001 0 -9999 0 -10000 0 0
MAK 0.01 0.051 -9999 0 -0.19 1 1
response to oxidative stress 0 0 -9999 0 -10000 0 0
HIP1 0.02 0.011 -9999 0 -10000 0 0
GSN 0.025 0.006 -9999 0 -10000 0 0
NCOA2 0.025 0 -9999 0 -10000 0 0
NCOA6 0.026 0 -9999 0 -10000 0 0
DNA-PK 0.049 0 -9999 0 -10000 0 0
NCOA4 0.003 0.081 -9999 0 -0.31 1 1
PIAS3 0.024 0.006 -9999 0 -10000 0 0
cell proliferation 0.011 0.029 -9999 0 -10000 0 0
XRCC5 0.025 0 -9999 0 -10000 0 0
UBE3A 0.025 0.006 -9999 0 -10000 0 0
T-DHT/AR/SNURF 0.016 0.025 -9999 0 -10000 0 0
FHL2 0.025 0.019 -9999 0 -10000 0 0
RANBP9 0.026 0 -9999 0 -10000 0 0
JMJD1A 0.015 0.044 -9999 0 -0.14 1 1
CDK6 -0.004 0.08 -9999 0 -0.31 1 1
TGFB1I1 0.01 0.051 -9999 0 -0.18 1 1
T-DHT/AR/CyclinD1 0.011 0.067 -9999 0 -0.14 2 2
XRCC6 0.025 0 -9999 0 -10000 0 0
T-DHT/AR 0.022 0.045 -9999 0 -0.14 1 1
CTDSP1 0.025 0 -9999 0 -10000 0 0
CTDSP2 0.024 0 -9999 0 -10000 0 0
BRCA1 0.023 0.009 -9999 0 -10000 0 0
TCF4 0.022 0.006 -9999 0 -10000 0 0
CDKN2A 0.021 0.008 -9999 0 -10000 0 0
SRF 0.03 0 -9999 0 -10000 0 0
NKX3-1 0.003 0.054 -9999 0 -0.2 1 1
KLK3 0.016 0.021 -9999 0 -10000 0 0
TMF1 0.025 0 -9999 0 -10000 0 0
HNRNPA1 -0.001 0 -9999 0 -10000 0 0
AOF2 0.025 0.006 -9999 0 -10000 0 0
APPL1 -0.006 0.002 -9999 0 -10000 0 0
T-DHT/AR/Caspase 8 0.03 0.032 -9999 0 -10000 0 0
AR 0.02 0.025 -9999 0 -10000 0 0
UBA3 0 0 -9999 0 -10000 0 0
PATZ1 -0.001 0 -9999 0 -10000 0 0
PAWR 0.025 0 -9999 0 -10000 0 0
PRKDC 0.025 0 -9999 0 -10000 0 0
PA2G4 0.024 0 -9999 0 -10000 0 0
UBE2I 0.022 0.008 -9999 0 -10000 0 0
T-DHT/AR/Cyclin D3/CDK11 p58 0.029 0.029 -9999 0 -10000 0 0
RPS6KA3 0.026 0 -9999 0 -10000 0 0
T-DHT/AR/ARA70 0.015 0.058 -9999 0 -0.17 1 1
LATS2 0.024 0 -9999 0 -10000 0 0
T-DHT/AR/PRX1 0.026 0.03 -9999 0 -10000 0 0
Cyclin D3/CDK11 p58 0.018 0 -9999 0 -10000 0 0
VAV3 0.024 0.006 -9999 0 -10000 0 0
KLK2 0.024 0.02 -9999 0 -10000 0 0
CASP8 0.025 0 -9999 0 -10000 0 0
T-DHT/AR/TIF2/CARM1 0.048 0.031 -9999 0 -10000 0 0
TMPRSS2 -0.027 0.18 -9999 0 -0.73 1 1
CCND1 -0.014 0.082 -9999 0 -0.19 3 3
PIAS1 0.027 0 -9999 0 -10000 0 0
mol:T-DHT -0.001 0.014 -9999 0 -0.053 1 1
CDC2L1 0 0 -9999 0 -10000 0 0
PIAS4 0.027 0 -9999 0 -10000 0 0
T-DHT/AR/CDK6 0.007 0.061 -9999 0 -0.2 1 1
CMTM2 0.023 0.006 -9999 0 -10000 0 0
SNURF 0 0 -9999 0 -10000 0 0
ZMIZ1 -0.001 0.014 -9999 0 -0.053 1 1
CCND3 0.025 0 -9999 0 -10000 0 0
TGIF1 -0.001 0 -9999 0 -10000 0 0
FKBP4 0.026 0 -9999 0 -10000 0 0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Figure S45.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S45.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SMAD4 0.023 0.006 -9999 0 -10000 0 0
SMAD2 0.011 0.035 -9999 0 -10000 0 0
SMAD3 0.023 0.029 -9999 0 -10000 0 0
SMAD3/SMAD4 0.035 0.016 -9999 0 -10000 0 0
SMAD4/Ubc9/PIASy 0.041 0.02 -9999 0 -10000 0 0
SMAD2/SMAD2/SMAD4 0.041 0.045 -9999 0 -10000 0 0
PPM1A 0.022 0.008 -9999 0 -10000 0 0
CALM1 0.022 0.008 -9999 0 -10000 0 0
SMAD2/SMAD4 0.015 0.048 -9999 0 -10000 0 0
MAP3K1 0.003 0.081 -9999 0 -0.31 1 1
TRAP-1/SMAD4 0.035 0.009 -9999 0 -10000 0 0
MAPK3 0.022 0.008 -9999 0 -10000 0 0
MAPK1 0.025 0 -9999 0 -10000 0 0
NUP214 0.023 0.006 -9999 0 -10000 0 0
CTDSP1 0.025 0 -9999 0 -10000 0 0
CTDSP2 0.025 0 -9999 0 -10000 0 0
CTDSPL 0.023 0.006 -9999 0 -10000 0 0
KPNB1 0.012 0.051 -9999 0 -0.19 1 1
TGFBRAP1 0.025 0 -9999 0 -10000 0 0
UBE2I 0.022 0.008 -9999 0 -10000 0 0
NUP153 0.025 0 -9999 0 -10000 0 0
KPNA2 0.022 0.008 -9999 0 -10000 0 0
PIAS4 0.025 0 -9999 0 -10000 0 0
Nephrin/Neph1 signaling in the kidney podocyte

Figure S46.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S46.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
positive regulation of NF-kappaB transcription factor activity -0.022 0.028 -10000 0 -10000 0 0
KIRREL 0.015 0.021 -10000 0 -10000 0 0
Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.022 0.028 -10000 0 -10000 0 0
PLCG1 0.012 0.051 -10000 0 -0.19 1 1
ARRB2 0.023 0.006 -10000 0 -10000 0 0
WASL -0.005 0.079 -10000 0 -0.31 1 1
Nephrin/NEPH1/podocin/CD2AP 0.037 0.048 -10000 0 -10000 0 0
ChemicalAbstracts:57-88-5 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.001 0.052 -10000 0 -0.2 1 1
FYN 0.011 0.075 0.27 1 -10000 0 1
mol:Ca2+ 0.029 0.059 -10000 0 -10000 0 0
mol:DAG 0.03 0.059 -10000 0 -10000 0 0
NPHS2 0.005 0.053 -10000 0 -0.19 1 1
mol:IP3 0.03 0.059 -10000 0 -10000 0 0
regulation of endocytosis 0.026 0.051 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/Cholesterol 0.025 0.04 -10000 0 -10000 0 0
establishment of cell polarity 0.022 0.028 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/NCK1-2 0.034 0.093 -10000 0 -0.21 2 2
Nephrin/NEPH1/beta Arrestin2 0.028 0.052 -10000 0 -10000 0 0
NPHS1 0.019 0.023 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin 0.022 0.05 -10000 0 -10000 0 0
TJP1 0.025 0 -10000 0 -10000 0 0
NCK1 0.025 0 -10000 0 -10000 0 0
NCK2 -0.017 0.11 -10000 0 -0.31 2 2
heterophilic cell adhesion 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/PLCgamma1 0.031 0.06 -10000 0 -10000 0 0
CD2AP 0.025 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/GRB2 0.033 0.048 -10000 0 -10000 0 0
GRB2 0.022 0.008 -10000 0 -10000 0 0
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
TRPC6 -0.017 0.082 0.28 1 -10000 0 1
cytoskeleton organization 0.007 0.06 0.2 1 -10000 0 1
Nephrin/NEPH1 0.023 0.018 -10000 0 -10000 0 0
Nephrin/NEPH1/ZO-1 0.045 0.013 -10000 0 -10000 0 0
Canonical NF-kappaB pathway

Figure S47.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S47.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FBXW11 0.025 0.007 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.032 0.047 -9999 0 -10000 0 0
ERC1 0 0 -9999 0 -10000 0 0
RIP2/NOD2 0.019 0 -9999 0 -10000 0 0
NFKBIA -0.007 0.003 -9999 0 -10000 0 0
BIRC2 0.025 0 -9999 0 -10000 0 0
IKBKB 0.025 0 -9999 0 -10000 0 0
RIPK2 0.025 0 -9999 0 -10000 0 0
IKBKG 0.022 0.021 -9999 0 -10000 0 0
IKK complex/A20 0.059 0.041 -9999 0 -10000 0 0
NEMO/A20/RIP2 0.025 0 -9999 0 -10000 0 0
XPO1 0.025 0 -9999 0 -10000 0 0
NEMO/ATM 0.039 0.026 -9999 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 -9999 0 -10000 0 0
RAN 0.025 0 -9999 0 -10000 0 0
Exportin 1/RanGTP 0.034 0 -9999 0 -10000 0 0
IKK complex/ELKS 0.028 0.039 -9999 0 -10000 0 0
BCL10/MALT1/TRAF6 0.041 0.02 -9999 0 -10000 0 0
NOD2 0 0 -9999 0 -10000 0 0
NFKB1 0.006 0.08 -9999 0 -0.3 1 1
RELA 0.027 0 -9999 0 -10000 0 0
MALT1 0.023 0.006 -9999 0 -10000 0 0
cIAP1/UbcH5C 0.037 0 -9999 0 -10000 0 0
ATM 0.025 0 -9999 0 -10000 0 0
TNF/TNFR1A 0.027 0.039 -9999 0 -0.13 1 1
TRAF6 0.023 0.006 -9999 0 -10000 0 0
PRKCA 0.022 0.008 -9999 0 -10000 0 0
CHUK 0.003 0.081 -9999 0 -0.31 1 1
UBE2D3 0.025 0 -9999 0 -10000 0 0
TNF 0.012 0.051 -9999 0 -0.19 1 1
NF kappa B1 p50/RelA 0.055 0.014 -9999 0 -10000 0 0
BCL10 0.023 0.006 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process -0.007 0.003 -9999 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.025 0.007 -9999 0 -10000 0 0
TNFRSF1A 0.025 0 -9999 0 -10000 0 0
IKK complex 0.039 0.045 -9999 0 -10000 0 0
CYLD 0.023 0.006 -9999 0 -10000 0 0
IKK complex/PKC alpha 0.046 0.049 -9999 0 -10000 0 0
Signaling events mediated by HDAC Class II

Figure S48.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S48.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G beta1gamma2/HDAC5 0.053 0.025 -9999 0 -10000 0 0
HDAC3 0.023 0.006 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC4 -0.011 0.003 -9999 0 -10000 0 0
GATA1/HDAC4 0.015 0.054 -9999 0 -0.13 2 2
GATA1/HDAC5 0.015 0.054 -9999 0 -0.13 2 2
GATA2/HDAC5 0.035 0.009 -9999 0 -10000 0 0
HDAC5/BCL6/BCoR 0.048 0.012 -9999 0 -10000 0 0
HDAC9 0.019 0.011 -9999 0 -10000 0 0
Glucocorticoid receptor/Hsp90/HDAC6 0.032 0.008 -9999 0 -10000 0 0
HDAC4/ANKRA2 0.033 0.012 -9999 0 -10000 0 0
HDAC5/YWHAB 0.035 0.009 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1/Ubc9 0.011 0.004 -9999 0 -10000 0 0
GATA2 0.025 0 -9999 0 -10000 0 0
HDAC4/RFXANK 0.035 0.009 -9999 0 -10000 0 0
BCOR 0.025 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
HDAC10 0.025 0 -9999 0 -10000 0 0
HDAC5 0.023 0.006 -9999 0 -10000 0 0
GNB1/GNG2 0.033 0.012 -9999 0 -10000 0 0
Histones 0.038 0.033 -9999 0 -10000 0 0
ADRBK1 0.025 0 -9999 0 -10000 0 0
HDAC4 0.023 0.006 -9999 0 -10000 0 0
XPO1 0.025 0 -9999 0 -10000 0 0
HDAC5/ANKRA2 0.033 0.012 -9999 0 -10000 0 0
HDAC4/Ubc9 0.03 0.015 -9999 0 -10000 0 0
HDAC7 0 0 -9999 0 -10000 0 0
HDAC5/14-3-3 E 0.03 0.015 -9999 0 -10000 0 0
TUBA1B 0 0 -9999 0 -10000 0 0
HDAC6 0.025 0 -9999 0 -10000 0 0
HDAC5/RFXANK 0.035 0.009 -9999 0 -10000 0 0
CAMK4 0.023 0.006 -9999 0 -10000 0 0
Tubulin/HDAC6 0.021 0.051 -9999 0 -0.18 1 1
SUMO1 0.025 0 -9999 0 -10000 0 0
EntrezGene:9972 0 0 -9999 0 -10000 0 0
YWHAB 0.025 0 -9999 0 -10000 0 0
GATA1 -0.001 0.07 -9999 0 -0.19 2 2
EntrezGene:8021 0 0 -9999 0 -10000 0 0
YWHAE 0.022 0.008 -9999 0 -10000 0 0
NR3C1 0.023 0.006 -9999 0 -10000 0 0
SUMO1/HDAC4 0.045 0.024 -9999 0 -10000 0 0
SRF 0.025 0 -9999 0 -10000 0 0
HDAC4/YWHAB 0.035 0.009 -9999 0 -10000 0 0
Tubulin 0.004 0.055 -9999 0 -0.21 1 1
HDAC4/14-3-3 E 0.03 0.015 -9999 0 -10000 0 0
GNB1 0.023 0.006 -9999 0 -10000 0 0
RANGAP1 0.025 0 -9999 0 -10000 0 0
BCL6/BCoR 0.037 0 -9999 0 -10000 0 0
HDAC4/HDAC3/SMRT (N-CoR2) 0.045 0.017 -9999 0 -10000 0 0
HDAC4/SRF 0.045 0.017 -9999 0 -10000 0 0
HDAC4/ER alpha 0.004 0.083 -9999 0 -0.21 2 2
EntrezGene:23225 0 0 -9999 0 -10000 0 0
positive regulation of chromatin silencing 0.038 0.033 -9999 0 -10000 0 0
cell motility 0.02 0.051 -9999 0 -0.18 1 1
EntrezGene:23636 0 0 -9999 0 -10000 0 0
UBE2I 0.022 0.008 -9999 0 -10000 0 0
HDAC7/HDAC3 0.017 0.004 -9999 0 -10000 0 0
BCL6 0.025 0 -9999 0 -10000 0 0
HDAC4/CaMK II delta B 0.023 0.006 -9999 0 -10000 0 0
Hsp90/HDAC6 0.019 0 -9999 0 -10000 0 0
ESR1 -0.017 0.11 -9999 0 -0.31 2 2
HDAC6/HDAC11 0.037 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1 0.047 0.019 -9999 0 -10000 0 0
NPC 0.015 0 -9999 0 -10000 0 0
MEF2C 0.003 0.081 -9999 0 -0.31 1 1
RAN 0.025 0 -9999 0 -10000 0 0
HDAC4/MEF2C 0.046 0.06 -9999 0 -10000 0 0
GNG2 0.022 0.008 -9999 0 -10000 0 0
NCOR2 0.025 0 -9999 0 -10000 0 0
TUBB2A 0.004 0.081 -9999 0 -0.31 1 1
HDAC11 0.025 0 -9999 0 -10000 0 0
HSP90AA1 0 0 -9999 0 -10000 0 0
RANBP2 0.025 0 -9999 0 -10000 0 0
ANKRA2 0.023 0.006 -9999 0 -10000 0 0
RFXANK 0.025 0 -9999 0 -10000 0 0
nuclear import -0.026 0.012 -9999 0 -10000 0 0
ErbB4 signaling events

Figure S49.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S49.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ErbB4/ErbB4/HBEGF/HBEGF 0.026 0.017 -10000 0 -10000 0 0
epithelial cell differentiation -0.001 0.073 -10000 0 -10000 0 0
ITCH 0.028 0.003 -10000 0 -10000 0 0
WWP1 0.01 0.011 -10000 0 -10000 0 0
FYN -0.001 0.07 -10000 0 -0.19 2 2
EGFR -0.036 0.12 -10000 0 -0.27 3 3
PRL 0.025 0 -10000 0 -10000 0 0
neuron projection morphogenesis -0.015 0.032 -10000 0 -10000 0 0
PTPRZ1 0.002 0.05 -10000 0 -0.19 1 1
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC 0.041 0.049 -10000 0 -10000 0 0
ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta -0.005 0.054 -10000 0 -10000 0 0
ADAM17 0.014 0.052 -10000 0 -0.19 1 1
ErbB4/ErbB4 0.015 0.013 -10000 0 -10000 0 0
ErbB4/ErbB4/neuregulin 3/neuregulin 3 0.019 0.03 -10000 0 -10000 0 0
NCOR1 0.023 0.006 -10000 0 -10000 0 0
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn -0.004 0.073 -10000 0 -10000 0 0
GRIN2B -0.03 0.069 -10000 0 -10000 0 0
ErbB4/ErbB2/betacellulin 0.018 0.063 -10000 0 -10000 0 0
STAT1 0.012 0.051 -10000 0 -0.19 1 1
HBEGF 0.023 0.006 -10000 0 -10000 0 0
PRLR 0.012 0.051 -10000 0 -0.19 1 1
E4ICDs/ETO2 0.017 0.035 -10000 0 -10000 0 0
axon guidance -0.038 0.064 -10000 0 -10000 0 0
NEDD4 0.028 0.003 -10000 0 -10000 0 0
Prolactin receptor/Prolactin receptor/Prolactin 0.027 0.039 -10000 0 -0.13 1 1
CBFA2T3 0.01 0.051 -10000 0 -0.19 1 1
ErbB4/ErbB2/HBEGF 0.032 0.01 -10000 0 -10000 0 0
MAPK3 0.001 0.037 -10000 0 -10000 0 0
STAT1 (dimer) 0.018 0.031 -10000 0 -10000 0 0
MAPK1 0.002 0.037 -10000 0 -10000 0 0
JAK2 0.02 0.01 -10000 0 -10000 0 0
ErbB4/ErbB2/neuregulin 1 beta -0.004 0.052 -10000 0 -10000 0 0
NRG1 -0.033 0.07 -10000 0 -0.22 2 2
NRG3 0.01 0.051 -10000 0 -0.19 1 1
NRG2 0.01 0.051 -10000 0 -0.19 1 1
NRG4 0.004 0.081 -10000 0 -0.31 1 1
heart development -0.038 0.064 -10000 0 -10000 0 0
neural crest cell migration -0.004 0.052 -10000 0 -10000 0 0
ERBB2 -0.007 0.009 -10000 0 -10000 0 0
WWOX/E4ICDs 0.012 0.02 -10000 0 -10000 0 0
SHC1 0.023 0.006 -10000 0 -10000 0 0
ErbB4/EGFR/neuregulin 4 0.001 0.061 -10000 0 -10000 0 0
apoptosis -0.021 0.025 -10000 0 -10000 0 0
ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta 0.02 0.035 -10000 0 -10000 0 0
ErbB4/ErbB2/epiregulin 0.029 0.048 -10000 0 -10000 0 0
ErbB4/ErbB4/betacellulin/betacellulin 0.021 0.02 -10000 0 -10000 0 0
ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 0.055 0.031 -10000 0 -10000 0 0
MDM2 0.037 0.08 0.25 2 -10000 0 2
ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta 0.006 0.059 -10000 0 -10000 0 0
STAT5A -0.016 0.095 -10000 0 -10000 0 0
ErbB4/EGFR/neuregulin 1 beta -0.026 0.099 -10000 0 -0.27 2 2
DLG4 0.023 0.006 -10000 0 -10000 0 0
GRB2/SHC 0.033 0.012 -10000 0 -10000 0 0
E4ICDs/TAB2/NCoR1 0.042 0.013 -10000 0 -10000 0 0
STAT5A (dimer) 0.004 0.082 -10000 0 -10000 0 0
MAP3K7IP2 0.025 0 -10000 0 -10000 0 0
STAT5B (dimer) -0.031 0.067 -10000 0 -10000 0 0
LRIG1 -0.009 0.093 -10000 0 -0.25 2 2
EREG 0.004 0.081 -10000 0 -0.31 1 1
BTC -0.017 0.11 -10000 0 -0.31 2 2
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta -0.039 0.065 -10000 0 -10000 0 0
ERBB4 0.015 0.013 -10000 0 -10000 0 0
STAT5B 0.022 0.008 -10000 0 -10000 0 0
YAP1 -0.004 0.029 -10000 0 -10000 0 0
GRB2 0.022 0.008 -10000 0 -10000 0 0
ErbB4/ErbB2/neuregulin 4 0.029 0.048 -10000 0 -10000 0 0
glial cell differentiation -0.042 0.013 -10000 0 -10000 0 0
WWOX 0.016 0.012 -10000 0 -10000 0 0
cell proliferation -0.042 0.13 -10000 0 -0.42 1 1
BARD1 signaling events

Figure S50.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S50.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BARD1/CSTF1 0.037 0 -10000 0 -10000 0 0
ATM 0.025 0 -10000 0 -10000 0 0
UBE2D3 0.025 0 -10000 0 -10000 0 0
PRKDC 0.025 0 -10000 0 -10000 0 0
ATR 0.025 0 -10000 0 -10000 0 0
UBE2L3 0.025 0 -10000 0 -10000 0 0
FANCD2 0.018 0 -10000 0 -10000 0 0
protein ubiquitination 0.049 0.043 -10000 0 -10000 0 0
XRCC5 0.025 0 -10000 0 -10000 0 0
XRCC6 0.025 0 -10000 0 -10000 0 0
M/R/N Complex 0.048 0.012 -10000 0 -10000 0 0
MRE11A 0.025 0 -10000 0 -10000 0 0
DNA-PK 0.051 0 -10000 0 -10000 0 0
FA complex/FANCD2/Ubiquitin -0.002 0.091 -10000 0 -0.3 1 1
FANCF 0.023 0.006 -10000 0 -10000 0 0
BRCA1 0.022 0.008 -10000 0 -10000 0 0
CCNE1 0.012 0.051 -10000 0 -0.19 1 1
CDK2/Cyclin E1 0.027 0.039 -10000 0 -0.13 1 1
FANCG 0.022 0.008 -10000 0 -10000 0 0
BRCA1/BACH1/BARD1 0.033 0.012 -10000 0 -10000 0 0
FANCE 0.025 0 -10000 0 -10000 0 0
FANCC 0.01 0.051 -10000 0 -0.19 1 1
NBN 0.025 0 -10000 0 -10000 0 0
FANCA 0.01 0.051 -10000 0 -0.19 1 1
DNA repair 0.006 0.077 -10000 0 -10000 0 0
BRCA1/BARD1/ubiquitin 0.033 0.012 -10000 0 -10000 0 0
BARD1/DNA-PK 0.065 0 -10000 0 -10000 0 0
FANCL 0.025 0 -10000 0 -10000 0 0
mRNA polyadenylation -0.037 0 -10000 0 -10000 0 0
BRCA1/BARD1/CTIP/M/R/N Complex 0.021 0.02 -10000 0 -10000 0 0
BRCA1/BACH1/BARD1/TopBP1 0.045 0.017 -10000 0 -10000 0 0
BRCA1/BARD1/P53 0.042 0.058 -10000 0 -0.16 1 1
BARD1/CSTF1/BRCA1 0.045 0.017 -10000 0 -10000 0 0
BRCA1/BACH1 0.022 0.008 -10000 0 -10000 0 0
BARD1 0.025 0 -10000 0 -10000 0 0
PCNA 0.025 0 -10000 0 -10000 0 0
BRCA1/BARD1/UbcH5C 0.045 0.017 -10000 0 -10000 0 0
BRCA1/BARD1/UbcH7 0.045 0.017 -10000 0 -10000 0 0
BRCA1/BARD1/RAD51/PCNA 0.057 0.021 -10000 0 -10000 0 0
BARD1/DNA-PK/P53 0.056 0.058 -10000 0 -0.16 1 1
BRCA1/BARD1/Ubiquitin 0.033 0.012 -10000 0 -10000 0 0
BRCA1/BARD1/CTIP 0.033 0.016 -10000 0 -10000 0 0
FA complex -0.006 0.065 -10000 0 -0.2 1 1
BARD1/EWS 0.037 0 -10000 0 -10000 0 0
RBBP8 -0.01 0.003 -10000 0 -10000 0 0
TP53 0.003 0.081 -10000 0 -0.31 1 1
TOPBP1 0.025 0 -10000 0 -10000 0 0
G1/S transition of mitotic cell cycle -0.04 0.057 0.16 1 -10000 0 1
BRCA1/BARD1 0.055 0.046 -10000 0 -10000 0 0
CSTF1 0.025 0 -10000 0 -10000 0 0
BARD1/EWS-Fli1 0.019 0 -10000 0 -10000 0 0
CDK2 0.025 0 -10000 0 -10000 0 0
UniProt:Q9BZD1 0 0 -10000 0 -10000 0 0
RAD51 0.025 0 -10000 0 -10000 0 0
RAD50 0.023 0.006 -10000 0 -10000 0 0
BRCA1/BARD1/DNA-directed RNA polymerase II holoenzyme 0.033 0.012 -10000 0 -10000 0 0
EWSR1 0.025 0 -10000 0 -10000 0 0
Sphingosine 1-phosphate (S1P) pathway

Figure S51.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S51.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.025 0 -9999 0 -10000 0 0
SPHK1 0.009 0.051 -9999 0 -0.19 1 1
GNAI2 0.025 0 -9999 0 -10000 0 0
mol:S1P 0.007 0.014 -9999 0 -10000 0 0
GNAO1 0.023 0.006 -9999 0 -10000 0 0
mol:Sphinganine-1-P -0.017 0.028 -9999 0 -10000 0 0
growth factor activity 0 0 -9999 0 -10000 0 0
S1P/S1P2/G12/G13 0.024 0.031 -9999 0 -10000 0 0
GNAI3 0.023 0.006 -9999 0 -10000 0 0
G12/G13 0.023 0.018 -9999 0 -10000 0 0
S1PR3 0 0 -9999 0 -10000 0 0
S1PR2 0 0 -9999 0 -10000 0 0
EDG1 0.012 0.051 -9999 0 -0.19 1 1
S1P1/S1P 0.024 0.043 -9999 0 -10000 0 0
S1PR5 0 0 -9999 0 -10000 0 0
S1PR4 0 0 -9999 0 -10000 0 0
GNAI1 -0.002 0.08 -9999 0 -0.31 1 1
S1P/S1P5/G12 0.021 0.031 -9999 0 -10000 0 0
S1P/S1P3/Gq 0 0.07 -9999 0 -0.21 1 1
S1P/S1P4/Gi 0.029 0.059 -9999 0 -10000 0 0
GNAQ 0 0 -9999 0 -10000 0 0
GNAZ 0.025 0 -9999 0 -10000 0 0
GNA14 0.003 0.081 -9999 0 -0.31 1 1
GNA15 0.025 0 -9999 0 -10000 0 0
GNA12 0.019 0.011 -9999 0 -10000 0 0
GNA13 0.022 0.008 -9999 0 -10000 0 0
GNA11 -0.001 0.07 -9999 0 -0.19 2 2
ABCC1 0.022 0.008 -9999 0 -10000 0 0
Circadian rhythm pathway

Figure S52.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S52.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
chromatin modification 0.022 0.06 -9999 0 -10000 0 0
CLOCK 0.027 0 -9999 0 -10000 0 0
TIMELESS/CRY2 0.03 0.019 -9999 0 -10000 0 0
DEC1/BMAL1 0.036 0.009 -9999 0 -10000 0 0
ATR 0.025 0 -9999 0 -10000 0 0
NR1D1 0.016 0.015 -9999 0 -10000 0 0
ARNTL 0.025 0.007 -9999 0 -10000 0 0
TIMELESS 0.018 0.014 -9999 0 -10000 0 0
NPAS2 0.006 0.081 -9999 0 -0.31 1 1
CRY2 0.023 0.006 -9999 0 -10000 0 0
mol:CO -0.009 0 -9999 0 -10000 0 0
CHEK1 -0.017 0.11 -9999 0 -0.31 2 2
mol:HEME 0.009 0 -9999 0 -10000 0 0
PER1 0.003 0.081 -9999 0 -0.31 1 1
BMAL/CLOCK/NPAS2 0.044 0.058 -9999 0 -0.17 1 1
BMAL1/CLOCK 0.023 0.046 -9999 0 -10000 0 0
S phase of mitotic cell cycle 0.022 0.06 -9999 0 -10000 0 0
TIMELESS/CHEK1/ATR 0.022 0.06 -9999 0 -10000 0 0
mol:NADPH 0.009 0 -9999 0 -10000 0 0
PER1/TIMELESS 0.02 0.052 -9999 0 -10000 0 0
PER1-2 / CRY1-2 0 0 -9999 0 -10000 0 0
DEC1 0.023 0.006 -9999 0 -10000 0 0
JNK signaling in the CD4+ TCR pathway

Figure S53.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S53.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
LAT/GRAP2/SLP76/HPK1 0.042 0.044 -9999 0 -10000 0 0
MAP4K1 0.025 0 -9999 0 -10000 0 0
MAP3K8 0.023 0.006 -9999 0 -10000 0 0
PRKCB 0 0 -9999 0 -10000 0 0
DBNL 0.019 0.011 -9999 0 -10000 0 0
CRKL 0.025 0 -9999 0 -10000 0 0
MAP3K1 0.039 0.042 -9999 0 -10000 0 0
JUN -0.038 0.12 -9999 0 -0.34 2 2
MAP3K7 0.039 0.042 -9999 0 -10000 0 0
GRAP2 0.023 0.006 -9999 0 -10000 0 0
CRK 0.022 0.008 -9999 0 -10000 0 0
MAP2K4 0.026 0.063 -9999 0 -10000 0 0
LAT 0.022 0.008 -9999 0 -10000 0 0
LCP2 0.009 0.051 -9999 0 -0.19 1 1
MAPK8 -0.037 0.16 -9999 0 -0.45 2 2
LAT/GRAP2/SLP76/HPK1/HIP-55/CRK family 0.046 0.044 -9999 0 -10000 0 0
LAT/GRAP2/SLP76/HPK1/HIP-55 0.032 0.049 -9999 0 -10000 0 0
Noncanonical Wnt signaling pathway

Figure S54.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S54.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC2 0.004 0.081 -9999 0 -0.31 1 1
GNB1/GNG2 0.021 0.067 -9999 0 -10000 0 0
mol:DAG -0.009 0.055 -9999 0 -10000 0 0
PLCG1 -0.009 0.056 -9999 0 -10000 0 0
YES1 -0.014 0.059 -9999 0 -10000 0 0
FZD3 0.01 0.051 -9999 0 -0.19 1 1
FZD6 0.025 0 -9999 0 -10000 0 0
G protein 0.014 0.063 -9999 0 -10000 0 0
MAP3K7 -0.02 0.036 -9999 0 -10000 0 0
mol:Ca2+ -0.009 0.054 -9999 0 -10000 0 0
mol:IP3 -0.009 0.055 -9999 0 -10000 0 0
NLK -0.011 0.17 -9999 0 -0.66 1 1
GNB1 0.023 0.006 -9999 0 -10000 0 0
CAMK2A -0.009 0.041 -9999 0 -10000 0 0
MAP3K7IP1 0.023 0.006 -9999 0 -10000 0 0
Noncanonical Wnts/FZD -0.002 0.064 -9999 0 -0.17 2 2
CSNK1A1 0.023 0.006 -9999 0 -10000 0 0
GNAS -0.01 0.058 -9999 0 -10000 0 0
GO:0007205 -0.015 0.051 -9999 0 -10000 0 0
WNT6 0.025 0 -9999 0 -10000 0 0
WNT4 0.023 0.006 -9999 0 -10000 0 0
NFAT1/CK1 alpha 0.024 0.083 -9999 0 -10000 0 0
GNG2 0.022 0.008 -9999 0 -10000 0 0
WNT5A 0.004 0.081 -9999 0 -0.31 1 1
WNT11 0.025 0 -9999 0 -10000 0 0
CDC42 0 0.056 -9999 0 -10000 0 0
Syndecan-2-mediated signaling events

Figure S55.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S55.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Syndecan-2/Fibronectin 0.019 0.03 -10000 0 -10000 0 0
EPHB2 -0.018 0.11 -10000 0 -0.31 2 2
Syndecan-2/TACI 0.025 0.006 -10000 0 -10000 0 0
LAMA1 0.022 0.008 -10000 0 -10000 0 0
Syndecan-2/alpha2 ITGB1 0.027 0.059 -10000 0 -0.15 1 1
HRAS 0.025 0 -10000 0 -10000 0 0
Syndecan-2/CASK 0.008 0 -10000 0 -10000 0 0
ITGA5 0.025 0 -10000 0 -10000 0 0
BAX -0.006 0.037 -10000 0 -10000 0 0
EPB41 0.01 0.051 -10000 0 -0.19 1 1
positive regulation of cell-cell adhesion 0.017 0.027 -10000 0 -10000 0 0
LAMA3 -0.011 0.092 -10000 0 -0.25 2 2
EZR 0 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
CAV2 -0.026 0.11 -10000 0 -0.31 2 2
Syndecan-2/MMP2 0.025 0.006 -10000 0 -10000 0 0
RP11-540L11.1 0 0 -10000 0 -10000 0 0
alpha2 ITGB1 0.033 0.012 -10000 0 -10000 0 0
dendrite morphogenesis 0 0.065 -10000 0 -0.17 2 2
Syndecan-2/GM-CSF 0 0.066 -10000 0 -0.17 2 2
determination of left/right symmetry 0.011 0 -10000 0 -10000 0 0
Syndecan-2/PKC delta 0.027 0 -10000 0 -10000 0 0
GNB2L1 0.023 0.006 -10000 0 -10000 0 0
MAPK3 0 0.041 -10000 0 -0.16 1 1
MAPK1 -0.01 0.056 -10000 0 -0.16 2 2
Syndecan-2/RACK1 0.037 0.01 -10000 0 -10000 0 0
NF1 0.025 0 -10000 0 -10000 0 0
FGFR/FGF/Syndecan-2 0.011 0 -10000 0 -10000 0 0
ITGA2 0.023 0.006 -10000 0 -10000 0 0
MAPK8 -0.003 0.043 -10000 0 -10000 0 0
Syndecan-2/alpha2/beta1 Integrin 0.045 0.022 -10000 0 -10000 0 0
Syndecan-2/Kininogen 0.027 0 -10000 0 -10000 0 0
ITGB1 0.023 0.006 -10000 0 -10000 0 0
SRC 0.022 0.038 0.17 1 -10000 0 1
Syndecan-2/CASK/Protein 4.1 0.016 0.027 -10000 0 -10000 0 0
extracellular matrix organization 0.027 0 -10000 0 -10000 0 0
actin cytoskeleton reorganization 0.019 0.03 -10000 0 -10000 0 0
Syndecan-2/Caveolin-2/Ras 0.001 0.063 -10000 0 -0.16 2 2
Syndecan-2/Laminin alpha3 0.005 0.055 -10000 0 -0.17 1 1
Syndecan-2/RasGAP 0.048 0.012 -10000 0 -10000 0 0
alpha5/beta1 Integrin 0.035 0.009 -10000 0 -10000 0 0
PRKCD 0.025 0 -10000 0 -10000 0 0
Syndecan-2 dimer 0 0.065 -10000 0 -0.17 2 2
GO:0007205 0.002 0 -10000 0 -10000 0 0
DNA mediated transformation 0 0 -10000 0 -10000 0 0
Syndecan-2/RasGAP/Src 0.031 0.008 -10000 0 -10000 0 0
RHOA 0.004 0.081 -10000 0 -0.31 1 1
SDCBP 0.012 0.051 -10000 0 -0.19 1 1
TNFRSF13B 0.023 0.006 -10000 0 -10000 0 0
RASA1 0.023 0.006 -10000 0 -10000 0 0
alpha2/beta1 Integrin 0.033 0.012 -10000 0 -10000 0 0
Syndecan-2/Synbindin 0.025 0.006 -10000 0 -10000 0 0
TGFB1 0.025 0 -10000 0 -10000 0 0
CASP3 0.012 0 -10000 0 -10000 0 0
FN1 0.012 0.051 -10000 0 -0.19 1 1
Syndecan-2/IL8 -0.046 0.086 -10000 0 -0.17 4 4
SDC2 0.011 0 -10000 0 -10000 0 0
KNG1 0.025 0 -10000 0 -10000 0 0
Syndecan-2/Neurofibromin 0.027 0 -10000 0 -10000 0 0
TRAPPC4 0.023 0.006 -10000 0 -10000 0 0
CSF2 -0.018 0.11 -10000 0 -0.31 2 2
Syndecan-2/TGFB1 0.027 0 -10000 0 -10000 0 0
Syndecan-2/Syntenin/PI-4-5-P2 0.018 0.027 -10000 0 -10000 0 0
Syndecan-2/Ezrin 0.013 0.043 -10000 0 -0.15 1 1
PRKACA 0.012 0 -10000 0 -10000 0 0
angiogenesis -0.046 0.086 -10000 0 -0.17 4 4
MMP2 0.023 0.006 -10000 0 -10000 0 0
IL8 -0.098 0.14 -10000 0 -0.26 7 7
calcineurin-NFAT signaling pathway 0.025 0.006 -10000 0 -10000 0 0
Cellular roles of Anthrax toxin

Figure S56.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S56.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ANTXR1 0.025 0 -9999 0 -10000 0 0
ANTXR2 0.025 0 -9999 0 -10000 0 0
negative regulation of myeloid dendritic cell antigen processing and presentation -0.001 0 -9999 0 -10000 0 0
monocyte activation -0.047 0.13 -9999 0 -0.31 3 3
MAP2K2 0.015 0 -9999 0 -10000 0 0
MAP2K1 -0.005 0 -9999 0 -10000 0 0
MAP2K7 -0.005 0 -9999 0 -10000 0 0
MAP2K6 -0.004 0.002 -9999 0 -10000 0 0
CYAA -0.007 0 -9999 0 -10000 0 0
MAP2K4 -0.004 0.001 -9999 0 -10000 0 0
IL1B -0.038 0.055 -9999 0 -0.14 3 3
Channel 0.032 0 -9999 0 -10000 0 0
NLRP1 -0.001 0 -9999 0 -10000 0 0
CALM1 0.022 0.008 -9999 0 -10000 0 0
negative regulation of phagocytosis -0.037 0.13 -9999 0 -0.37 2 2
mol:Ca2+ 0 0 -9999 0 -10000 0 0
regulation of endothelial cell proliferation 0.001 0 -9999 0 -10000 0 0
MAPK3 -0.004 0.002 -9999 0 -10000 0 0
MAPK1 -0.005 0 -9999 0 -10000 0 0
PGR -0.005 0 -9999 0 -10000 0 0
PA/Cellular Receptors 0.034 0 -9999 0 -10000 0 0
apoptosis -0.001 0 -9999 0 -10000 0 0
LOC728358 0 0 -9999 0 -10000 0 0
Lethal toxin (unfolded) 0.031 0 -9999 0 -10000 0 0
macrophage activation -0.007 0.003 -9999 0 -10000 0 0
TNF 0.012 0.051 -9999 0 -0.19 1 1
VCAM1 -0.032 0.12 -9999 0 -0.35 2 2
platelet activation -0.037 0.13 -9999 0 -0.37 2 2
MAPKKK cascade -0.005 0.023 -9999 0 -0.066 2 2
IL18 -0.011 0.033 -9999 0 -0.14 1 1
negative regulation of macrophage activation -0.001 0 -9999 0 -10000 0 0
LEF -0.001 0 -9999 0 -10000 0 0
CASP1 0.001 0.002 -9999 0 -10000 0 0
mol:cAMP -0.037 0.13 -9999 0 -0.37 2 2
necrosis -0.001 0 -9999 0 -10000 0 0
intracellular pH reduction 0 0 -9999 0 -10000 0 0
PAGA 0 0 -9999 0 -10000 0 0
Edema toxin (unfolded) 0.032 0 -9999 0 -10000 0 0
mol:Epigallocatechin-3-gallate (EGCG) 0 0 -9999 0 -10000 0 0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)

Figure S57.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S57.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MET/RANBP9 0.023 0.018 -10000 0 -10000 0 0
CRKL 0.063 0.07 -10000 0 -10000 0 0
mol:PIP3 0.002 0.002 -10000 0 -10000 0 0
AKT1 0.019 0.066 -10000 0 -10000 0 0
PTK2B 0.023 0.006 -10000 0 -10000 0 0
RAPGEF1 0.061 0.062 -10000 0 -10000 0 0
RANBP10 0.023 0.006 -10000 0 -10000 0 0
PIK3CA 0.025 0 -10000 0 -10000 0 0
HGF/MET/SHIP2 0.032 0.025 -10000 0 -10000 0 0
MAP3K5 0.06 0.08 -10000 0 -10000 0 0
HGF/MET/CIN85/CBL/ENDOPHILINS 0.04 0.031 -10000 0 -10000 0 0
AP1 0.012 0.084 -10000 0 -0.15 2 2
mol:SU11274 0 0 -10000 0 -10000 0 0
SHC1 0.023 0.006 -10000 0 -10000 0 0
apoptosis -0.12 0.3 -10000 0 -0.63 4 4
STAT3 (dimer) 0.018 0.038 -10000 0 -10000 0 0
GAB1/CRKL/SHP2/PI3K 0.085 0.068 -10000 0 -10000 0 0
INPP5D 0 0 -10000 0 -10000 0 0
CBL/CRK 0.085 0.082 0.27 1 -10000 0 1
PTPN11 0.025 0 -10000 0 -10000 0 0
GO:0007205 0 0 -10000 0 -10000 0 0
PLCG1 0.012 0.051 -10000 0 -0.19 1 1
PTEN 0.025 0 -10000 0 -10000 0 0
ELK1 0.098 0.16 0.3 6 -10000 0 6
mol:SU5416 0 0 -10000 0 -10000 0 0
SHP2/GRB2/SOS1GAB1 0.01 0.01 -10000 0 -10000 0 0
PAK1 0.006 0.072 -10000 0 -10000 0 0
HGF/MET/RANBP10 0.029 0.025 -10000 0 -10000 0 0
HRAS 0.032 0.047 -10000 0 -10000 0 0
DOCK1 0.056 0.068 -10000 0 -10000 0 0
GAB1 0.068 0.076 -10000 0 -10000 0 0
CRK 0.072 0.088 0.27 1 -10000 0 1
mol:PHA665752 0 0 -10000 0 -10000 0 0
mol:GDP 0.016 0.016 -10000 0 -10000 0 0
JUN -0.003 0.07 -10000 0 -0.19 2 2
EntrezGene:200958 0 0 -10000 0 -10000 0 0
HGF/MET 0.006 0.006 -10000 0 -10000 0 0
PIK3R1 0.023 0.006 -10000 0 -10000 0 0
cell morphogenesis 0.05 0.062 -10000 0 -10000 0 0
GRB2/SHC 0.077 0.06 0.17 4 -10000 0 4
FOS -0.033 0.12 -10000 0 -0.27 3 3
GLMN 0.002 0.014 -10000 0 -10000 0 0
cell motility 0.098 0.16 0.3 6 -10000 0 6
HGF/MET/MUC20 0.021 0.016 -10000 0 -10000 0 0
cell migration 0.055 0.054 0.17 2 -10000 0 2
GRB2 0.022 0.008 -10000 0 -10000 0 0
CBL 0.025 0 -10000 0 -10000 0 0
MET/RANBP10 0.021 0.018 -10000 0 -10000 0 0
HGF/MET/Paxillin/FAK1/FAK12/RasGAP 0.015 0.013 -10000 0 -10000 0 0
MET/MUC20 0.012 0.009 -10000 0 -10000 0 0
RAP1B 0.049 0.068 -10000 0 -10000 0 0
RAP1A 0.043 0.068 -10000 0 -10000 0 0
HGF/MET/RANBP9 0.032 0.025 -10000 0 -10000 0 0
RAF1 0.062 0.063 -10000 0 -10000 0 0
STAT3 0.018 0.038 -10000 0 -10000 0 0
cell proliferation 0.061 0.071 -10000 0 -10000 0 0
RPS6KB1 0.022 0.032 0.12 1 -10000 0 1
MAPK3 0.094 0.14 0.28 5 -10000 0 5
MAPK1 0.09 0.14 -10000 0 -10000 0 0
RANBP9 0.025 0 -10000 0 -10000 0 0
MAPK8 0.021 0.14 -10000 0 -0.35 1 1
SRC 0.015 0.024 -10000 0 -10000 0 0
PI3K 0.072 0.069 0.17 4 -10000 0 4
MET/Glomulin 0.01 0.017 -10000 0 -10000 0 0
SOS1 0.025 0 -10000 0 -10000 0 0
MAP2K1 0.063 0.057 -10000 0 -10000 0 0
MET 0.016 0.012 -10000 0 -10000 0 0
MAP4K1 0.073 0.072 -10000 0 -10000 0 0
PTK2 0.025 0 -10000 0 -10000 0 0
MAP2K2 0.063 0.057 -10000 0 -10000 0 0
BAD 0.006 0.072 -10000 0 -10000 0 0
MAP2K4 0.052 0.077 -10000 0 -10000 0 0
SHP2/GRB2/SOS1/GAB1 0.026 0.026 -10000 0 -10000 0 0
INPPL1 0.025 0 -10000 0 -10000 0 0
PXN 0.025 0 -10000 0 -10000 0 0
SH3KBP1 0.025 0 -10000 0 -10000 0 0
HGS 0.003 0.003 -10000 0 -10000 0 0
PLCgamma1/PKC 0.01 0.034 -10000 0 -0.12 1 1
HGF 0.019 0.011 -10000 0 -10000 0 0
RASA1 0.023 0.006 -10000 0 -10000 0 0
NCK1 0.025 0 -10000 0 -10000 0 0
PTPRJ 0.023 0.006 -10000 0 -10000 0 0
NCK/PLCgamma1 0.051 0.056 0.17 1 -10000 0 1
PDPK1 0.024 0.071 -10000 0 -10000 0 0
HGF/MET/SHIP 0.021 0.016 -10000 0 -10000 0 0
Hedgehog signaling events mediated by Gli proteins

Figure S58.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S58.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.023 0.006 -10000 0 -10000 0 0
HDAC2 0.025 0 -10000 0 -10000 0 0
GNB1/GNG2 0.018 0.057 -10000 0 -0.18 1 1
forebrain development 0.03 0.11 -10000 0 -0.31 1 1
GNAO1 0.024 0.006 -10000 0 -10000 0 0
SMO/beta Arrestin2 0.008 0.06 -10000 0 -0.21 1 1
SMO -0.003 0.08 -10000 0 -0.31 1 1
ARRB2 0.024 0.006 -10000 0 -10000 0 0
GLI3/SPOP -0.038 0.12 -10000 0 -0.31 2 2
mol:GTP 0 0.001 -10000 0 -10000 0 0
GSK3B 0.025 0 -10000 0 -10000 0 0
GNAI2 0.025 0.001 -10000 0 -10000 0 0
SIN3/HDAC complex 0.061 0.016 -10000 0 -10000 0 0
GNAI1 -0.002 0.08 -10000 0 -0.31 1 1
XPO1 0.025 0.002 -10000 0 -10000 0 0
GLI1/Su(fu) -0.01 0.077 -10000 0 -10000 0 0
SAP30 0.023 0.006 -10000 0 -10000 0 0
mol:GDP -0.003 0.08 -10000 0 -0.31 1 1
MIM/GLI2A 0 0.071 -10000 0 -0.18 2 2
IFT88 0.004 0.081 -10000 0 -0.31 1 1
GNAI3 0.024 0.006 -10000 0 -10000 0 0
GLI2 0.023 0.023 -10000 0 -10000 0 0
GLI3 -0.049 0.12 -10000 0 -0.32 2 2
CSNK1D 0.022 0.008 -10000 0 -10000 0 0
CSNK1E 0.025 0 -10000 0 -10000 0 0
SAP18 0.025 0 -10000 0 -10000 0 0
embryonic digit morphogenesis 0.004 0.081 -10000 0 -0.31 1 1
GNG2 0.022 0.008 -10000 0 -10000 0 0
Gi family/GTP -0.014 0.06 -10000 0 -0.17 1 1
SIN3B 0.025 0 -10000 0 -10000 0 0
SIN3A 0.025 0 -10000 0 -10000 0 0
GLI3/Su(fu) -0.045 0.12 -10000 0 -0.33 2 2
GLI2/Su(fu) 0.019 0.017 -10000 0 -10000 0 0
FOXA2 0.025 0.041 -10000 0 -10000 0 0
neural tube patterning 0.03 0.11 -10000 0 -0.31 1 1
SPOP 0.025 0 -10000 0 -10000 0 0
Su(fu)/PIAS1 0.035 0.071 -10000 0 -10000 0 0
GNB1 0.023 0.006 -10000 0 -10000 0 0
CSNK1G2 0.01 0.051 -10000 0 -0.19 1 1
CSNK1G3 0.023 0.006 -10000 0 -10000 0 0
MTSS1 0 0.071 -10000 0 -0.18 2 2
embryonic limb morphogenesis 0.03 0.11 -10000 0 -0.31 1 1
SUFU 0.004 0.036 -10000 0 -10000 0 0
LGALS3 0.001 0.08 -10000 0 -0.31 1 1
catabolic process 0.003 0.093 -10000 0 -0.26 1 1
GLI3A/CBP 0.008 0.077 -10000 0 -0.29 1 1
KIF3A 0.023 0.006 -10000 0 -10000 0 0
GLI1 0.029 0.11 -10000 0 -0.32 1 1
RAB23 0.012 0.051 -10000 0 -0.19 1 1
CSNK1A1 0.023 0.006 -10000 0 -10000 0 0
IFT172 0.004 0.081 -10000 0 -0.31 1 1
RBBP7 0.025 0 -10000 0 -10000 0 0
Su(fu)/Galectin3 0.019 0.08 -10000 0 -10000 0 0
GNAZ 0.025 0.001 -10000 0 -10000 0 0
RBBP4 0.003 0.081 -10000 0 -0.31 1 1
CSNK1G1 0.025 0 -10000 0 -10000 0 0
PIAS1 0.025 0 -10000 0 -10000 0 0
PRKACA 0.025 0 -10000 0 -10000 0 0
GLI2/SPOP 0.046 0.041 0.18 1 -10000 0 1
STK36 0.025 0.002 -10000 0 -10000 0 0
Gi family/GNB1/GNG2/GDP -0.007 0.053 -10000 0 -10000 0 0
PTCH1 0.029 0.1 -10000 0 -0.29 1 1
MIM/GLI1 0.03 0.12 -10000 0 -10000 0 0
CREBBP 0.008 0.077 -10000 0 -0.29 1 1
Su(fu)/SIN3/HDAC complex -0.002 0.12 -10000 0 -0.42 1 1
Presenilin action in Notch and Wnt signaling

Figure S59.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S59.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Delta 1/NOTCH/NOTCH(cleaved) 0.008 0.1 -10000 0 -0.37 1 1
HDAC1 0.025 0.011 -10000 0 -10000 0 0
AES 0.025 0.002 -10000 0 -10000 0 0
FBXW11 0.023 0.006 -10000 0 -10000 0 0
DTX1 0.012 0.051 -10000 0 -0.19 1 1
LRP6/FZD1 0.026 0.017 -10000 0 -10000 0 0
TLE1 0.024 0.006 -10000 0 -10000 0 0
AP1 -0.017 0.07 -10000 0 -0.19 2 2
NCSTN 0.023 0.006 -10000 0 -10000 0 0
ADAM10 0.025 0 -10000 0 -10000 0 0
Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 0.005 0.064 -10000 0 -10000 0 0
NICD/RBPSUH -0.006 0.093 -10000 0 -0.36 1 1
WIF1 0.025 0 -10000 0 -10000 0 0
NOTCH1 -0.005 0.098 -10000 0 -0.38 1 1
PSENEN 0.025 0 -10000 0 -10000 0 0
KREMEN2 0.009 0.051 -10000 0 -0.19 1 1
DKK1 -0.018 0.11 -10000 0 -0.31 2 2
beta catenin/beta TrCP1 -0.025 0.1 -10000 0 -0.25 2 2
APH1B 0.012 0.051 -10000 0 -0.19 1 1
APH1A -0.011 0.092 -10000 0 -0.25 2 2
AXIN1 0.014 0.055 -10000 0 -10000 0 0
CtBP/CBP/TCF1/TLE1/AES 0.021 0.034 0.14 1 -10000 0 1
PSEN1 0.022 0.008 -10000 0 -10000 0 0
FOS -0.033 0.12 -10000 0 -0.27 3 3
JUN -0.003 0.07 -10000 0 -0.19 2 2
MAP3K7 0.026 0.004 -10000 0 -10000 0 0
CTNNB1 -0.029 0.1 -10000 0 -0.26 2 2
MAPK3 0.022 0.008 -10000 0 -10000 0 0
DKK2/LRP6/Kremen 2 0.035 0.04 -10000 0 -10000 0 0
HNF1A 0 0.002 -10000 0 -10000 0 0
CTBP1 0.024 0.007 -10000 0 -10000 0 0
MYC -0.049 0.27 -10000 0 -1.1 1 1
NKD1 0.024 0.006 -10000 0 -10000 0 0
FZD1 0.017 0.012 -10000 0 -10000 0 0
NOTCH1 precursor/Deltex homolog 1 0.001 0.099 -10000 0 -0.37 1 1
apoptosis -0.017 0.07 -10000 0 -0.19 2 2
Delta 1/NOTCHprecursor 0.001 0.099 -10000 0 -0.37 1 1
DLL1 0.012 0.051 -10000 0 -0.19 1 1
PPARD 0.016 0.023 -10000 0 -10000 0 0
Gamma Secretase 0.03 0.075 -10000 0 -0.16 1 1
APC -0.011 0.11 -10000 0 -0.37 1 1
DVL1 0.007 0.018 -10000 0 -10000 0 0
CSNK2A1 0.025 0.001 -10000 0 -10000 0 0
MAP3K7IP1 0.024 0.008 -10000 0 -10000 0 0
DKK1/LRP6/Kremen 2 0.006 0.081 -10000 0 -0.16 3 3
LRP6 0.025 0 -10000 0 -10000 0 0
CSNK1A1 0.023 0.006 -10000 0 -10000 0 0
NLK 0.019 0.011 -10000 0 -10000 0 0
CCND1 -0.006 0.054 -10000 0 -10000 0 0
WNT1 0.025 0 -10000 0 -10000 0 0
Axin1/APC/beta catenin -0.002 0.089 -10000 0 -10000 0 0
DKK2 0.025 0 -10000 0 -10000 0 0
NOTCH1 precursor/DVL1 0.018 0.093 -10000 0 -0.32 1 1
GSK3B 0.025 0.001 -10000 0 -10000 0 0
FRAT1 0.024 0.006 -10000 0 -10000 0 0
NOTCH/Deltex homolog 1 0.008 0.1 -10000 0 -0.37 1 1
PPP2R5D 0.006 0.078 -10000 0 -0.28 1 1
MAPK1 0.025 0 -10000 0 -10000 0 0
WNT1/LRP6/FZD1 0.044 0.03 -10000 0 -10000 0 0
RBPJ 0 0 -10000 0 -10000 0 0
CREBBP 0.02 0.011 -10000 0 -10000 0 0
Aurora A signaling

Figure S60.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S60.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Aurora A/GADD45A -0.005 0.059 -9999 0 -0.17 1 1
BIRC5 0.022 0.008 -9999 0 -10000 0 0
NFKBIA -0.003 0.003 -9999 0 -10000 0 0
CPEB1 0.012 0.051 -9999 0 -0.19 1 1
AKT1 -0.004 0.001 -9999 0 -10000 0 0
NDEL1 0.023 0.006 -9999 0 -10000 0 0
Aurora A/BRCA1 0.019 0.007 -9999 0 -10000 0 0
NDEL1/TACC3 0.023 0.045 -9999 0 -0.15 1 1
GADD45A -0.024 0.1 -9999 0 -0.23 3 3
GSK3B 0.024 0.001 -9999 0 -10000 0 0
PAK1/Aurora A 0.013 0.048 -9999 0 -0.17 1 1
MDM2 0.022 0.008 -9999 0 -10000 0 0
JUB 0.023 0.006 -9999 0 -10000 0 0
TPX2 -0.032 0.045 -9999 0 -0.13 3 3
TP53 -0.003 0.066 -9999 0 -0.26 1 1
DLG7 -0.01 0.023 -9999 0 -10000 0 0
AURKAIP1 0 0 -9999 0 -10000 0 0
ARHGEF7 0.025 0 -9999 0 -10000 0 0
G2 phase of mitotic cell cycle 0 0 -9999 0 -10000 0 0
Aurora A/NDEL1/TACC3 0.024 0.048 -9999 0 -0.16 1 1
G2/M transition of mitotic cell cycle 0.019 0.007 -9999 0 -10000 0 0
AURKA 0.009 0.002 -9999 0 -10000 0 0
AURKB 0.003 0.041 -9999 0 -0.16 1 1
CDC25B 0.009 0.008 -9999 0 -10000 0 0
G2/M transition checkpoint 0.021 0.006 -9999 0 -10000 0 0
mRNA polyadenylation 0.015 0.025 -9999 0 -10000 0 0
Aurora A/CPEB 0.016 0.025 -9999 0 -10000 0 0
Aurora A/TACC1/TRAP/chTOG 0.042 0.036 -9999 0 -10000 0 0
BRCA1 0.022 0.008 -9999 0 -10000 0 0
centrosome duplication 0.013 0.048 -9999 0 -0.17 1 1
regulation of centrosome cycle 0.022 0.044 -9999 0 -0.15 1 1
spindle assembly 0.04 0.035 -9999 0 -10000 0 0
TDRD7 0.01 0.051 -9999 0 -0.19 1 1
Aurora A/RasGAP/Survivin 0.04 0.019 -9999 0 -10000 0 0
CENPA 0.015 0.004 -9999 0 -10000 0 0
Aurora A/PP2A 0.025 0.002 -9999 0 -10000 0 0
meiosis 0 0 -9999 0 -10000 0 0
protein catabolic process -0.003 0.024 -9999 0 -10000 0 0
negative regulation of DNA binding -0.015 0.078 -9999 0 -0.22 2 2
prophase 0 0 -9999 0 -10000 0 0
GIT1/beta-PIX 0.037 0 -9999 0 -10000 0 0
RASA1 0.023 0.006 -9999 0 -10000 0 0
Ajuba/Aurora A 0.021 0.006 -9999 0 -10000 0 0
mitotic prometaphase 0.001 0.017 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.009 0.002 -9999 0 -10000 0 0
TACC1 0.025 0 -9999 0 -10000 0 0
TACC3 0.004 0.081 -9999 0 -0.31 1 1
Aurora A/Antizyme1 0.022 0.002 -9999 0 -10000 0 0
Aurora A/RasGAP 0.023 0.006 -9999 0 -10000 0 0
OAZ1 0.025 0 -9999 0 -10000 0 0
RAN 0.025 0 -9999 0 -10000 0 0
mitosis 0 0 -9999 0 -10000 0 0
PRKACA 0.024 0.001 -9999 0 -10000 0 0
GIT1 0.025 0 -9999 0 -10000 0 0
GIT1/beta-PIX/PAK1 0.037 0.056 -9999 0 -0.18 1 1
Importin alpha/Importin beta/TPX2 -0.032 0.045 -9999 0 -0.13 3 3
PPP2R5D 0.025 0 -9999 0 -10000 0 0
Aurora A/TPX2 -0.006 0.04 -9999 0 -10000 0 0
PAK1 0.004 0.081 -9999 0 -0.31 1 1
CKAP5 0.023 0.006 -9999 0 -10000 0 0
p75(NTR)-mediated signaling

Figure S61.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S61.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Sortilin/TRAF6 0.033 0.012 -9999 0 -10000 0 0
Necdin/E2F1 -0.046 0.11 -9999 0 -0.18 6 6
proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E 0.052 0.02 -9999 0 -10000 0 0
NGF (dimer)/p75(NTR)/BEX1 -0.031 0.087 -9999 0 -0.14 6 6
NT-4/5 (dimer)/p75(NTR) 0.019 0 -9999 0 -10000 0 0
IKBKB 0.025 0 -9999 0 -10000 0 0
AKT1 -0.012 0.005 -9999 0 -10000 0 0
IKBKG 0.025 0 -9999 0 -10000 0 0
BDNF -0.016 0.082 -9999 0 -0.19 3 3
MGDIs/NGR/p75(NTR)/LINGO1 0.021 0.051 -9999 0 -0.18 1 1
FURIN 0.025 0 -9999 0 -10000 0 0
proBDNF (dimer)/p75(NTR)/Sortilin 0.015 0.061 -9999 0 -10000 0 0
LINGO1 0 0 -9999 0 -10000 0 0
Sortilin/TRAF6/NRIF 0 0.057 -9999 0 -10000 0 0
proBDNF (dimer) -0.016 0.082 -9999 0 -0.19 3 3
NTRK1 0.023 0.006 -9999 0 -10000 0 0
RTN4R 0.004 0.081 -9999 0 -0.31 1 1
neuron apoptosis -0.017 0.057 -9999 0 -10000 0 0
IRAK1 0.025 0 -9999 0 -10000 0 0
SHC1 0.011 0.003 -9999 0 -10000 0 0
ARHGDIA 0.022 0.008 -9999 0 -10000 0 0
RhoA/GTP 0.004 0.055 -9999 0 -0.21 1 1
Gamma Secretase 0.03 0.075 -9999 0 -0.16 1 1
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 0.019 0.055 -9999 0 -10000 0 0
MAGEH1 -0.015 0.082 -9999 0 -0.19 3 3
proNGF (dimer)/p75(NTR)/Sortilin/Necdin -0.021 0.092 -9999 0 -0.16 4 4
Mammalian IAPs/DIABLO 0 0.085 -9999 0 -0.16 3 3
proNGF (dimer) 0 0 -9999 0 -10000 0 0
MAGED1 0.025 0 -9999 0 -10000 0 0
APP 0.009 0.051 -9999 0 -0.19 1 1
NT-4/5 (dimer) 0 0 -9999 0 -10000 0 0
ZNF274 0.025 0 -9999 0 -10000 0 0
RhoA/GDP/RHOGDI 0.018 0.045 -9999 0 -0.15 1 1
NGF 0 0 -9999 0 -10000 0 0
cell cycle arrest 0.014 0.04 -9999 0 -10000 0 0
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK 0.021 0.005 -9999 0 -10000 0 0
NT-4/5 (dimer)/p75(NTR)/TRAF6 0.032 0.008 -9999 0 -10000 0 0
NCSTN 0.023 0.006 -9999 0 -10000 0 0
mol:GTP 0.031 0.008 -9999 0 -10000 0 0
PSENEN 0.025 0 -9999 0 -10000 0 0
mol:ceramide 0.011 0.003 -9999 0 -10000 0 0
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs 0.016 0.006 -9999 0 -10000 0 0
p75(NTR)/beta APP 0.022 0.04 -9999 0 -0.13 1 1
BEX1 -0.077 0.14 -9999 0 -0.25 6 6
mol:GDP -0.004 0 -9999 0 -10000 0 0
NGF (dimer) -0.027 0.1 -9999 0 -0.18 4 4
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI 0.042 0.016 -9999 0 -10000 0 0
PIK3R1 0.023 0.006 -9999 0 -10000 0 0
RAC1/GTP 0.022 0.013 -9999 0 -10000 0 0
MYD88 0.025 0 -9999 0 -10000 0 0
CHUK 0.003 0.081 -9999 0 -0.31 1 1
NGF (dimer)/p75(NTR)/PKA 0.032 0.008 -9999 0 -10000 0 0
RHOB 0.025 0 -9999 0 -10000 0 0
RHOA 0.004 0.081 -9999 0 -0.31 1 1
MAGE-G1/E2F1 0.037 0 -9999 0 -10000 0 0
NT3 (dimer) 0.025 0 -9999 0 -10000 0 0
TP53 -0.038 0.043 -9999 0 -10000 0 0
PRDM4 0.011 0.003 -9999 0 -10000 0 0
BDNF (dimer) -0.047 0.12 -9999 0 -0.2 5 5
PIK3CA 0.025 0 -9999 0 -10000 0 0
SORT1 0.023 0.006 -9999 0 -10000 0 0
activation of caspase activity 0.047 0.018 -9999 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 0.042 0.016 -9999 0 -10000 0 0
RHOC 0.023 0.006 -9999 0 -10000 0 0
XIAP 0 0 -9999 0 -10000 0 0
MAPK10 -0.009 0.08 -9999 0 -0.22 1 1
DIABLO 0.025 0 -9999 0 -10000 0 0
SMPD2 0.011 0.003 -9999 0 -10000 0 0
APH1B 0.012 0.051 -9999 0 -0.19 1 1
APH1A -0.011 0.092 -9999 0 -0.25 2 2
proNGF (dimer)/p75(NTR)/Sortilin 0.032 0.008 -9999 0 -10000 0 0
PSEN1 0.022 0.008 -9999 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.019 0.061 -9999 0 -0.21 1 1
NT3 (dimer)/p75(NTR) 0.037 0 -9999 0 -10000 0 0
MAPK8 -0.003 0.076 -9999 0 -10000 0 0
MAPK9 -0.002 0.07 -9999 0 -10000 0 0
APAF1 0.004 0.081 -9999 0 -0.31 1 1
NTF3 0.025 0 -9999 0 -10000 0 0
NTF4 0 0 -9999 0 -10000 0 0
NDN -0.085 0.15 -9999 0 -0.27 6 6
RAC1/GDP 0.014 0.008 -9999 0 -10000 0 0
RhoA-B-C/GDP 0.039 0.05 -9999 0 -0.15 1 1
p75 CTF/Sortilin/TRAF6/NRIF 0.051 0.038 -9999 0 -10000 0 0
RhoA-B-C/GTP 0.031 0.008 -9999 0 -10000 0 0
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.034 0.066 -9999 0 -10000 0 0
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 0.026 0.063 -9999 0 -10000 0 0
PRKACB 0.023 0.006 -9999 0 -10000 0 0
proBDNF (dimer)/p75 ECD -0.006 0.07 -9999 0 -0.13 4 4
ChemicalAbstracts:86-01-1 0 0 -9999 0 -10000 0 0
BIRC3 -0.051 0.13 -9999 0 -0.28 4 4
BIRC2 0.025 0 -9999 0 -10000 0 0
neuron projection morphogenesis -0.009 0.064 -9999 0 -10000 0 0
BAD -0.008 0.082 -9999 0 -10000 0 0
RIPK2 0.025 0 -9999 0 -10000 0 0
NGFR 0.025 0 -9999 0 -10000 0 0
CYCS -0.01 0.006 -9999 0 -10000 0 0
ADAM17 0.012 0.051 -9999 0 -0.19 1 1
NGF (dimer)/p75(NTR)/TRAF6/RIP2 0.045 0.012 -9999 0 -10000 0 0
BCL2L11 -0.007 0.076 -9999 0 -10000 0 0
BDNF (dimer)/p75(NTR) 0.004 0.063 -9999 0 -0.13 3 3
PI3K 0.045 0.012 -9999 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 0.045 0.012 -9999 0 -10000 0 0
NDNL2 0.025 0 -9999 0 -10000 0 0
YWHAE 0.022 0.008 -9999 0 -10000 0 0
PRKCI 0.025 0 -9999 0 -10000 0 0
NGF (dimer)/p75(NTR) 0.019 0 -9999 0 -10000 0 0
ChemicalAbstracts:146-91-8 0 0 -9999 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/NRAGE 0.045 0.012 -9999 0 -10000 0 0
TRAF6 0.023 0.006 -9999 0 -10000 0 0
RAC1 0.019 0.011 -9999 0 -10000 0 0
PRKCZ 0 0 -9999 0 -10000 0 0
PLG 0.012 0.051 -9999 0 -0.19 1 1
oligodendrocyte cell fate commitment 0 0 -9999 0 -10000 0 0
CASP6 -0.003 0.035 -9999 0 -10000 0 0
SQSTM1 0.023 0.006 -9999 0 -10000 0 0
NGFRAP1 0.025 0 -9999 0 -10000 0 0
CASP3 -0.006 0.075 -9999 0 -10000 0 0
E2F1 0.025 0 -9999 0 -10000 0 0
CASP9 0.023 0.006 -9999 0 -10000 0 0
IKK complex 0.031 0.05 -9999 0 -10000 0 0
NGF (dimer)/TRKA 0.017 0.004 -9999 0 -10000 0 0
MMP7 -0.085 0.15 -9999 0 -0.27 6 6
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.052 0.02 -9999 0 -10000 0 0
MMP3 0.012 0.051 -9999 0 -0.19 1 1
APAF-1/Caspase 9 -0.05 0.056 -9999 0 -10000 0 0
Arf6 downstream pathway

Figure S62.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S62.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLAUR 0.013 0.03 -10000 0 -10000 0 0
regulation of axonogenesis 0.012 0.062 0.23 1 -10000 0 1
myoblast fusion -0.022 0.021 -10000 0 -10000 0 0
mol:GTP 0 0.055 -10000 0 -0.15 2 2
regulation of calcium-dependent cell-cell adhesion -0.029 0.046 -10000 0 -10000 0 0
ARF1/GTP 0.023 0.037 -10000 0 -10000 0 0
mol:GM1 -0.005 0.038 -10000 0 -0.11 1 1
mol:Choline -0.01 0.047 -10000 0 -0.16 1 1
lamellipodium assembly -0.009 0.082 -10000 0 -0.31 1 1
MAPK3 0.014 0.029 -10000 0 -10000 0 0
ARF6/GTP/NME1/Tiam1 0.03 0.046 -10000 0 -10000 0 0
ARF1 0.023 0.006 -10000 0 -10000 0 0
ARF6/GDP 0.022 0.021 -10000 0 -10000 0 0
ARF1/GDP 0.016 0.055 -10000 0 -0.18 1 1
ARF6 0.027 0.011 -10000 0 -10000 0 0
RAB11A 0.025 0 -10000 0 -10000 0 0
TIAM1 0.023 0.009 -10000 0 -10000 0 0
fibronectin binding 0 0 -10000 0 -10000 0 0
MAPK1 0.009 0.037 -10000 0 -10000 0 0
actin filament bundle formation -0.006 0.077 0.18 1 -10000 0 1
KALRN 0.012 0.013 -10000 0 -10000 0 0
RAB11FIP3/RAB11A 0.033 0.012 -10000 0 -10000 0 0
RhoA/GDP 0.006 0.077 -10000 0 -0.18 1 1
NME1 0.025 0.007 -10000 0 -10000 0 0
Rac1/GDP 0.007 0.066 -10000 0 -0.18 1 1
substrate adhesion-dependent cell spreading 0 0.055 -10000 0 -0.15 2 2
cortical actin cytoskeleton organization -0.01 0.082 -10000 0 -0.31 1 1
RAC1 0.019 0.011 -10000 0 -10000 0 0
liver development 0 0.055 -10000 0 -0.15 2 2
ARF6/GTP 0 0.055 -10000 0 -0.15 2 2
RhoA/GTP 0.003 0.068 -10000 0 -0.18 1 1
mol:GDP 0.002 0.052 -10000 0 -0.2 1 1
ARF6/GTP/RAB11FIP3/RAB11A 0.035 0.039 -10000 0 -10000 0 0
RHOA 0.004 0.081 -10000 0 -0.31 1 1
PLD1 -0.01 0.062 -10000 0 -0.18 1 1
RAB11FIP3 0.022 0.008 -10000 0 -10000 0 0
tube morphogenesis -0.009 0.082 -10000 0 -0.31 1 1
ruffle organization -0.012 0.062 -10000 0 -0.23 1 1
regulation of epithelial cell migration 0 0.055 -10000 0 -0.15 2 2
PLD2 0.009 0.032 -10000 0 -10000 0 0
PIP5K1A -0.012 0.063 -10000 0 -0.23 1 1
mol:Phosphatidic acid -0.01 0.047 -10000 0 -0.16 1 1
Rac1/GTP -0.01 0.082 -10000 0 -0.31 1 1
Aurora C signaling

Figure S63.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S63.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
INCENP 0.025 0 -9999 0 -9999 0 0
Aurora C/Aurora B/INCENP 0.045 0.012 -9999 0 -9999 0 0
metaphase 0 0 -9999 0 -9999 0 0
mitosis 0 0 -9999 0 -9999 0 0
H3F3B 0.01 0.004 -9999 0 -9999 0 0
AURKB 0.023 0.006 -9999 0 -9999 0 0
AURKC 0.025 0 -9999 0 -9999 0 0
FOXA2 and FOXA3 transcription factor networks

Figure S64.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S64.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ACADVL -0.053 0.18 -10000 0 -10000 0 0
PCK1 -0.14 0.33 -10000 0 -0.93 2 2
HNF4A -0.045 0.18 -10000 0 -10000 0 0
KCNJ11 -0.054 0.21 -10000 0 -10000 0 0
AKT1 -0.031 0.14 -10000 0 -10000 0 0
response to starvation 0.003 0.001 -10000 0 -10000 0 0
DLK1 -0.065 0.2 -10000 0 -0.51 1 1
NKX2-1 -0.004 0.15 0.28 2 -0.3 1 3
ACADM -0.077 0.24 -10000 0 -0.77 1 1
TAT -0.021 0.13 -10000 0 -10000 0 0
CEBPB 0.025 0.013 -10000 0 -10000 0 0
CEBPA 0.002 0.074 -10000 0 -0.19 2 2
TTR -0.04 0.16 -10000 0 -0.5 1 1
PKLR -0.057 0.19 -10000 0 -10000 0 0
APOA1 -0.067 0.23 -10000 0 -10000 0 0
CPT1C -0.06 0.18 -10000 0 -10000 0 0
ALAS1 -0.016 0.12 -10000 0 -10000 0 0
TFRC -0.058 0.16 -10000 0 -10000 0 0
FOXF1 -0.039 0.13 -10000 0 -0.31 3 3
NF1 0.03 0 -10000 0 -10000 0 0
HNF1A (dimer) -0.024 0.055 -10000 0 -0.16 2 2
CPT1A -0.084 0.24 -10000 0 -0.69 1 1
HMGCS1 -0.053 0.18 -10000 0 -10000 0 0
NR3C1 0.018 0.031 -10000 0 -10000 0 0
CPT1B -0.053 0.18 -10000 0 -10000 0 0
chromatin remodeling 0 0 -10000 0 -10000 0 0
SP1 0.025 0 -10000 0 -10000 0 0
GCK -0.021 0.24 -10000 0 -0.73 1 1
CREB1 -0.012 0.079 -10000 0 -0.2 2 2
IGFBP1 -0.003 0.12 -10000 0 -10000 0 0
PDX1 -0.044 0.15 -10000 0 -0.32 2 2
UCP2 -0.053 0.18 -10000 0 -10000 0 0
ALDOB -0.062 0.21 -10000 0 -10000 0 0
AFP 0.003 0.047 -10000 0 -10000 0 0
BDH1 -0.04 0.2 -10000 0 -10000 0 0
HADH -0.058 0.2 -10000 0 -0.5 1 1
F2 -0.075 0.23 -10000 0 -10000 0 0
HNF1A -0.024 0.055 -10000 0 -0.16 2 2
G6PC -0.014 0.095 -10000 0 -10000 0 0
SLC2A2 -0.15 0.36 -10000 0 -1 2 2
INS -0.023 0.082 -10000 0 -0.32 1 1
FOXA1 0.016 0.055 -10000 0 -10000 0 0
FOXA3 -0.01 0.092 -10000 0 -10000 0 0
FOXA2 -0.059 0.25 -10000 0 -0.58 1 1
ABCC8 -0.062 0.21 -10000 0 -10000 0 0
ALB 0.007 0.041 -10000 0 -10000 0 0
BMP receptor signaling

Figure S65.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S65.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BMP7/BMPR2/BMPR1A-1B/FS 0.023 0.082 -9999 0 -0.17 1 1
SMAD6-7/SMURF1 0.035 0.024 -9999 0 -10000 0 0
NOG 0.022 0.008 -9999 0 -10000 0 0
SMAD9 -0.004 0.1 -9999 0 -0.39 1 1
SMAD4 0.023 0.006 -9999 0 -10000 0 0
SMAD5 -0.015 0.063 -9999 0 -10000 0 0
BMP7/USAG1 -0.093 0.12 -9999 0 -0.2 8 8
SMAD5/SKI -0.005 0.067 -9999 0 -10000 0 0
SMAD1 0.006 0.042 -9999 0 -10000 0 0
BMP2 0.004 0.081 -9999 0 -0.31 1 1
SMAD1/SMAD1/SMAD4 0.016 0.036 -9999 0 -10000 0 0
BMPR1A 0.023 0.006 -9999 0 -10000 0 0
BMPR1B 0.012 0.051 -9999 0 -0.19 1 1
BMPR1A-1B/BAMBI 0.025 0.052 -9999 0 -10000 0 0
AHSG 0.012 0.051 -9999 0 -0.19 1 1
CER1 0.022 0.008 -9999 0 -10000 0 0
BMP2-4/CER1 0.011 0.072 -9999 0 -0.18 1 1
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA 0.007 0.052 -9999 0 -10000 0 0
BMP2-4 (homodimer) -0.003 0.076 -9999 0 -0.16 3 3
RGMB 0.023 0.006 -9999 0 -10000 0 0
BMP6/BMPR2/BMPR1A-1B 0.006 0.088 -9999 0 -0.16 2 2
RGMA 0.025 0 -9999 0 -10000 0 0
SMURF1 0.017 0.012 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP 0.003 0.046 -9999 0 -10000 0 0
BMP2-4/USAG1 -0.085 0.1 -9999 0 -0.21 5 5
SMAD6/SMURF1/SMAD5 -0.004 0.049 -9999 0 -10000 0 0
SOSTDC1 -0.12 0.14 -9999 0 -0.26 8 8
BMP7/BMPR2/BMPR1A-1B 0.025 0.075 -9999 0 -0.18 1 1
SKI 0.023 0.006 -9999 0 -10000 0 0
BMP6 (homodimer) -0.043 0.12 -9999 0 -0.25 4 4
HFE2 0.023 0.006 -9999 0 -10000 0 0
ZFYVE16 0.023 0.006 -9999 0 -10000 0 0
MAP3K7 0.025 0 -9999 0 -10000 0 0
BMP2-4/CHRD 0.011 0.072 -9999 0 -0.18 1 1
SMAD5/SMAD5/SMAD4 -0.011 0.068 -9999 0 -10000 0 0
MAPK1 0.025 0 -9999 0 -10000 0 0
TAK1/TAB family 0.027 0.057 -9999 0 -10000 0 0
BMP7 (homodimer) -0.015 0.082 -9999 0 -0.19 3 3
NUP214 0.023 0.006 -9999 0 -10000 0 0
BMP6/FETUA -0.025 0.095 -9999 0 -0.16 5 5
SMAD1/SKI 0.024 0.035 -9999 0 -10000 0 0
SMAD6 0.025 0 -9999 0 -10000 0 0
CTDSP2 0.025 0 -9999 0 -10000 0 0
BMP2-4/FETUA 0.005 0.083 -9999 0 -0.19 2 2
MAP3K7IP1 0.023 0.006 -9999 0 -10000 0 0
GREM1 0.012 0.051 -9999 0 -0.19 1 1
BMPR2 (homodimer) 0.025 0 -9999 0 -10000 0 0
GADD34/PP1CA 0.048 0.012 -9999 0 -10000 0 0
BMPR1A-1B (homodimer) 0.025 0.04 -9999 0 -0.13 1 1
CHRDL1 0.012 0.051 -9999 0 -0.19 1 1
ENDOFIN/SMAD1 0.024 0.035 -9999 0 -10000 0 0
SMAD6-7/SMURF1/SMAD1 0.027 0.04 -9999 0 -10000 0 0
SMAD6/SMURF1 0.017 0.012 -9999 0 -10000 0 0
BAMBI 0.01 0.051 -9999 0 -0.19 1 1
SMURF2 0.001 0.08 -9999 0 -0.31 1 1
BMP2-4/CHRDL1 0.005 0.075 -9999 0 -0.18 1 1
BMP2-4/GREM1 0.001 0.076 -9999 0 -0.18 1 1
SMAD7 0.023 0.006 -9999 0 -10000 0 0
SMAD8A/SMAD8A/SMAD4 -0.008 0.12 -9999 0 -0.32 2 2
SMAD1/SMAD6 0.01 0.032 -9999 0 -10000 0 0
TAK1/SMAD6 0.026 0.017 -9999 0 -10000 0 0
BMP7 -0.015 0.082 -9999 0 -0.19 3 3
BMP6 -0.043 0.12 -9999 0 -0.25 4 4
MAP3K7IP2 0.025 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 0.024 0.055 -9999 0 -10000 0 0
PPM1A 0.022 0.008 -9999 0 -10000 0 0
SMAD1/SMURF2 0.024 0.035 -9999 0 -10000 0 0
SMAD7/SMURF1 0.026 0.017 -9999 0 -10000 0 0
CTDSPL 0.023 0.006 -9999 0 -10000 0 0
PPP1CA 0.025 0 -9999 0 -10000 0 0
XIAP 0 0 -9999 0 -10000 0 0
CTDSP1 0.025 0 -9999 0 -10000 0 0
PPP1R15A 0.025 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS 0.002 0.049 -9999 0 -10000 0 0
CHRD 0.025 0 -9999 0 -10000 0 0
BMPR2 0.025 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM -0.002 0.053 -9999 0 -10000 0 0
BMP4 -0.004 0.069 -9999 0 -0.19 2 2
FST 0.01 0.051 -9999 0 -0.19 1 1
BMP2-4/NOG 0.007 0.071 -9999 0 -0.18 1 1
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 0.021 0.069 -9999 0 -0.17 1 1
PLK1 signaling events

Figure S66.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S66.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
regulation of centriole-centriole cohesion -0.002 0.014 -10000 0 -10000 0 0
BUB1B -0.003 0.033 -10000 0 -0.11 1 1
PLK1 -0.005 0.042 -10000 0 -0.15 1 1
PLK1S1 -0.003 0.022 -10000 0 -0.081 1 1
KIF2A -0.005 0.038 -10000 0 -0.14 1 1
regulation of mitotic centrosome separation -0.005 0.042 -10000 0 -0.15 1 1
GOLGA2 0.023 0.006 -10000 0 -10000 0 0
Hec1/SPC24 -0.011 0.032 -10000 0 -0.13 1 1
WEE1 -0.019 0.11 -10000 0 -0.43 1 1
cytokinesis 0.008 0.052 0.16 1 -10000 0 1
PP2A-alpha B56 0.005 0.15 -10000 0 -0.55 1 1
AURKA -0.004 0.024 -10000 0 -0.089 1 1
PICH/PLK1 -0.012 0.048 -10000 0 -0.16 1 1
CENPE -0.009 0.038 -10000 0 -0.14 1 1
RhoA/GTP 0.004 0.055 -10000 0 -0.21 1 1
positive regulation of microtubule depolymerization -0.005 0.038 -10000 0 -0.14 1 1
PPP2CA 0.023 0.006 -10000 0 -10000 0 0
FZR1 0.025 0 -10000 0 -10000 0 0
TPX2 -0.002 0.023 -10000 0 -10000 0 0
PAK1 0.004 0.083 -10000 0 -0.32 1 1
SPC24 0 0 -10000 0 -10000 0 0
FBXW11 0.023 0.006 -10000 0 -10000 0 0
CLSPN -0.009 0.049 -10000 0 -0.18 1 1
GORASP1 0.004 0.081 -10000 0 -0.31 1 1
metaphase 0.002 0.006 0.017 2 -10000 0 2
mol:GTP 0 0 -10000 0 -10000 0 0
NLP -0.003 0.022 -10000 0 -0.081 1 1
G2 phase of mitotic cell cycle 0 0.004 0.011 2 -10000 0 2
STAG2 0.025 0 -10000 0 -10000 0 0
GRASP65/GM130/RAB1/GTP -0.014 0.13 -10000 0 -0.52 1 1
spindle elongation -0.005 0.042 -10000 0 -0.15 1 1
ODF2 0.002 0.083 -10000 0 -0.32 1 1
BUB1 -0.015 0.15 -10000 0 -0.58 1 1
TPT1 0.003 0.022 -10000 0 -10000 0 0
CDC25C 0.01 0.03 -10000 0 -10000 0 0
CDC25B 0.023 0.011 -10000 0 -10000 0 0
SGOL1 0.002 0.014 -10000 0 -10000 0 0
RHOA 0.004 0.081 -10000 0 -0.31 1 1
CCNB1/CDK1 0.028 0.072 -10000 0 -0.22 1 1
CDC14B -0.005 0.004 -10000 0 -10000 0 0
CDC20 0.01 0.051 -10000 0 -0.19 1 1
PLK1/PBIP1 -0.014 0.051 -10000 0 -0.11 3 3
mitosis -0.001 0.003 0.008 1 -10000 0 1
FBXO5 -0.005 0.029 -10000 0 -0.11 1 1
CDC2 0.012 0.051 -10000 0 -0.18 1 1
NDC80 0 0 -10000 0 -10000 0 0
metaphase plate congression 0.006 0.022 -10000 0 -10000 0 0
ERCC6L -0.004 0.057 -10000 0 -0.21 1 1
NLP/gamma Tubulin 0.003 0.03 0.061 1 -0.092 1 2
microtubule cytoskeleton organization 0.003 0.022 -10000 0 -10000 0 0
G2/M transition DNA damage checkpoint 0 0.002 -10000 0 -10000 0 0
PPP1R12A 0.026 0.002 -10000 0 -10000 0 0
interphase 0 0.002 -10000 0 -10000 0 0
PLK1/PRC1-2 0.01 0.052 -10000 0 -0.14 1 1
GRASP65/GM130/RAB1/GTP/PLK1 0.018 0.057 -10000 0 -0.13 1 1
RAB1A 0.025 0 -10000 0 -10000 0 0
prophase 0 0 -10000 0 -10000 0 0
Aurora A/BORA -0.006 0.03 -10000 0 -0.12 1 1
mitotic prometaphase 0 0.001 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.01 0.017 -10000 0 -10000 0 0
microtubule-based process 0.005 0.042 -10000 0 -0.14 1 1
Golgi organization -0.005 0.042 -10000 0 -0.15 1 1
Cohesin/SA2 0.008 0.041 -10000 0 -0.13 1 1
PPP1CB/MYPT1 0.038 0.004 -10000 0 -10000 0 0
KIF20A 0.023 0.006 -10000 0 -10000 0 0
APC/C/CDC20 -0.001 0.047 -10000 0 -0.14 1 1
PPP2R1A 0.012 0.051 -10000 0 -0.19 1 1
chromosome segregation -0.014 0.051 -10000 0 -0.11 3 3
PRC1 0.012 0.051 -10000 0 -0.19 1 1
ECT2 -0.018 0.05 -10000 0 -0.14 2 2
C13orf34 -0.006 0.035 -10000 0 -0.13 1 1
NUDC 0.006 0.022 -10000 0 -10000 0 0
regulation of attachment of spindle microtubules to kinetochore -0.003 0.033 -10000 0 -0.11 1 1
spindle assembly 0.003 0.044 0.076 2 -0.13 1 3
spindle stabilization -0.003 0.022 -10000 0 -0.08 1 1
APC/C/HCDH1 0.021 0.006 -10000 0 -10000 0 0
MKLP2/PLK1 0.005 0.043 -10000 0 -0.14 1 1
CCNB1 0.012 0.051 -10000 0 -0.18 1 1
PPP1CB 0.026 0.002 -10000 0 -10000 0 0
BTRC 0.023 0.006 -10000 0 -10000 0 0
ROCK2 -0.002 0.046 -10000 0 -10000 0 0
TUBG1 0.008 0.027 -10000 0 -10000 0 0
G2/M transition of mitotic cell cycle -0.008 0.057 -10000 0 -0.21 1 1
MLF1IP -0.023 0.058 -10000 0 -0.17 2 2
INCENP 0.025 0.002 -10000 0 -10000 0 0
Insulin-mediated glucose transport

Figure S67.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S67.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Insulin responsive Vesicles 0.022 0.055 -9999 0 -10000 0 0
CaM/Ca2+ 0.016 0.006 -9999 0 -10000 0 0
AKT1 0.022 0.008 -9999 0 -10000 0 0
AKT2 0.012 0.051 -9999 0 -0.19 1 1
STXBP4 0.001 0.08 -9999 0 -0.31 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
mol:glucose 0.009 0.056 -9999 0 -10000 0 0
YWHAZ 0.025 0 -9999 0 -10000 0 0
CALM1 0.022 0.008 -9999 0 -10000 0 0
YWHAQ 0.004 0.081 -9999 0 -0.31 1 1
TBC1D4 -0.029 0.056 -9999 0 -0.17 2 2
mol:Ca2+ 0 0 -9999 0 -10000 0 0
YWHAH 0.012 0.051 -9999 0 -0.19 1 1
YWHAB 0.025 0 -9999 0 -10000 0 0
SNARE/Synip 0.017 0.051 -9999 0 -0.18 1 1
YWHAG 0.019 0.011 -9999 0 -10000 0 0
ASIP 0 0 -9999 0 -10000 0 0
PRKCI 0.025 0 -9999 0 -10000 0 0
AS160/CaM/Ca2+ 0.016 0.006 -9999 0 -10000 0 0
RHOQ 0.025 0 -9999 0 -10000 0 0
GYS1 0.003 0.014 -9999 0 -10000 0 0
PRKCZ 0 0 -9999 0 -10000 0 0
TRIP10 0.025 0 -9999 0 -10000 0 0
TC10/GTP/CIP4/Exocyst 0.034 0 -9999 0 -10000 0 0
AS160/14-3-3 -0.013 0.044 -9999 0 -10000 0 0
VAMP2 0.023 0.006 -9999 0 -10000 0 0
SLC2A4 0.008 0.059 -9999 0 -10000 0 0
STX4 0 0 -9999 0 -10000 0 0
GSK3B 0.011 0.019 -9999 0 -10000 0 0
SFN -0.001 0.07 -9999 0 -0.19 2 2
LNPEP 0.003 0.081 -9999 0 -0.31 1 1
YWHAE 0.022 0.008 -9999 0 -10000 0 0
PDGFR-alpha signaling pathway

Figure S68.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S68.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA 0.01 0.029 -9999 0 -10000 0 0
PDGF/PDGFRA/CRKL 0.028 0.024 -9999 0 -10000 0 0
positive regulation of JUN kinase activity 0.052 0.02 -9999 0 -10000 0 0
CRKL 0.025 0 -9999 0 -10000 0 0
PDGF/PDGFRA/Caveolin-3 0.028 0.024 -9999 0 -10000 0 0
AP1 -0.13 0.25 -9999 0 -0.77 2 2
mol:IP3 -0.025 0.047 -9999 0 -0.18 1 1
PLCG1 -0.025 0.047 -9999 0 -0.18 1 1
PDGF/PDGFRA/alphaV Integrin 0.012 0.066 -9999 0 -0.23 1 1
RAPGEF1 0.023 0.006 -9999 0 -10000 0 0
CRK 0.022 0.008 -9999 0 -10000 0 0
mol:Ca2+ -0.025 0.047 -9999 0 -0.18 1 1
CAV3 0.025 0 -9999 0 -10000 0 0
CAV1 -0.011 0.067 -9999 0 -0.19 2 2
SHC/Grb2/SOS1 0.054 0.021 -9999 0 -10000 0 0
PDGF/PDGFRA/Shf 0.012 0.066 -9999 0 -0.23 1 1
FOS -0.13 0.25 -9999 0 -0.76 2 2
JUN -0.043 0.046 -9999 0 -0.15 2 2
oligodendrocyte development 0.012 0.066 -9999 0 -0.23 1 1
GRB2 0.022 0.008 -9999 0 -10000 0 0
PIK3R1 0.023 0.006 -9999 0 -10000 0 0
mol:DAG -0.025 0.047 -9999 0 -0.18 1 1
PDGF/PDGFRA 0.01 0.029 -9999 0 -10000 0 0
actin cytoskeleton reorganization 0.022 0.025 -9999 0 -10000 0 0
SRF -0.003 0.017 -9999 0 -10000 0 0
SHC1 0.023 0.006 -9999 0 -10000 0 0
PI3K 0.045 0.013 -9999 0 -10000 0 0
PDGF/PDGFRA/Crk/C3G 0.039 0.019 -9999 0 -10000 0 0
JAK1 -0.013 0.011 -9999 0 -10000 0 0
ELK1/SRF -0.033 0.043 -9999 0 -10000 0 0
SHB 0.022 0.008 -9999 0 -10000 0 0
SHF 0.004 0.081 -9999 0 -0.31 1 1
CSNK2A1 0.03 0.02 -9999 0 -10000 0 0
GO:0007205 -0.02 0.044 -9999 0 -0.17 1 1
SOS1 0.025 0 -9999 0 -10000 0 0
Ras protein signal transduction 0.052 0.02 -9999 0 -10000 0 0
PDGF/PDGFRA/SHB 0.022 0.025 -9999 0 -10000 0 0
PDGF/PDGFRA/Caveolin-1 -0.002 0.053 -9999 0 -0.13 2 2
ITGAV 0.004 0.081 -9999 0 -0.31 1 1
ELK1 -0.036 0.063 -9999 0 -0.19 2 2
PIK3CA 0.025 0 -9999 0 -10000 0 0
PDGF/PDGFRA/Crk 0.023 0.025 -9999 0 -10000 0 0
JAK-STAT cascade -0.013 0.011 -9999 0 -10000 0 0
cell proliferation 0.012 0.066 -9999 0 -0.23 1 1
mTOR signaling pathway

Figure S69.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S69.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GBL 0.022 0.008 -10000 0 -10000 0 0
MKNK1 0.023 0.006 -10000 0 -10000 0 0
mol:PIP3 -0.012 0.044 -10000 0 -0.17 1 1
FRAP1 -0.002 0.073 -10000 0 -10000 0 0
AKT1 -0.009 0.035 -10000 0 -10000 0 0
INSR 0.025 0 -10000 0 -10000 0 0
Insulin Receptor/Insulin 0.021 0.051 -10000 0 -0.18 1 1
mol:GTP 0.01 0.048 -10000 0 -10000 0 0
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA/eIF3/40s Ribosomal subunit 0.004 0.025 -10000 0 -10000 0 0
TSC2 0.022 0.008 -10000 0 -10000 0 0
RHEB/GDP -0.003 0.041 -10000 0 -10000 0 0
TSC1 0.024 0.006 -10000 0 -10000 0 0
Insulin Receptor/IRS1 0.006 0.052 -10000 0 -0.19 1 1
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA 0.017 0.034 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
EIF3A 0 0 -10000 0 -10000 0 0
RPS6KB1 0.005 0.038 -10000 0 -10000 0 0
MAP3K5 -0.014 0.071 -10000 0 -0.29 1 1
PIK3R1 0.024 0.006 -10000 0 -10000 0 0
apoptosis -0.014 0.071 -10000 0 -0.29 1 1
mol:LY294002 0 0 -10000 0 -0.001 1 1
EIF4B 0.002 0.035 -10000 0 -10000 0 0
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.013 0.037 -10000 0 -10000 0 0
eIF4E/eIF4G1/eIF4A1 0.012 0.033 -10000 0 -10000 0 0
KIAA1303 0 0 -10000 0 -10000 0 0
PI3K 0.02 0.054 -10000 0 -0.17 1 1
mTOR/RHEB/GTP/Raptor/GBL -0.004 0.025 -10000 0 -10000 0 0
FKBP1A 0.025 0 -10000 0 -10000 0 0
RHEB/GTP 0.001 0.044 -10000 0 -10000 0 0
mol:Amino Acids 0 0 -10000 0 -0.001 1 1
FKBP12/Rapamycin 0.018 0.001 -10000 0 -10000 0 0
PDPK1 -0.016 0.039 -10000 0 -0.16 1 1
EIF4E 0.025 0 -10000 0 -10000 0 0
ASK1/PP5C -0.024 0.16 -10000 0 -0.54 1 1
mTOR/RHEB/GTP/Raptor/GBL/eIF4E 0.038 0.037 -10000 0 -10000 0 0
TSC1/TSC2 0.012 0.052 -10000 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 0.001 1 -10000 0 1
RPS6 0.009 0.051 -10000 0 -0.19 1 1
PPP5C 0.004 0.081 -10000 0 -0.31 1 1
EIF4G1 0.025 0 -10000 0 -10000 0 0
IRS1 -0.009 0.05 -10000 0 -0.2 1 1
INS 0.004 0.081 -10000 0 -0.31 1 1
PTEN 0.025 0.001 -10000 0 -10000 0 0
PDK2 -0.015 0.04 -10000 0 -0.16 1 1
EIF4EBP1 -0.04 0.25 -10000 0 -1 1 1
PIK3CA 0.025 0 -10000 0 -10000 0 0
PPP2R5D -0.004 0.068 -10000 0 -10000 0 0
peptide biosynthetic process -0.001 0.042 -10000 0 -0.16 1 1
RHEB 0.019 0.011 -10000 0 -10000 0 0
EIF4A1 0.023 0.006 -10000 0 -10000 0 0
mol:Rapamycin 0 0 -10000 0 -10000 0 0
EEF2 -0.001 0.042 -10000 0 -0.16 1 1
eIF4E/4E-BP1 -0.024 0.24 -10000 0 -0.94 1 1
IFN-gamma pathway

Figure S70.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S70.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 0.034 0.055 -10000 0 -10000 0 0
positive regulation of NF-kappaB transcription factor activity 0 0.002 -10000 0 -10000 0 0
CRKL 0.025 0 -10000 0 -10000 0 0
STAT1 (dimer)/Cbp/p300 0.018 0.086 -10000 0 -10000 0 0
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 0.033 0.029 -10000 0 -10000 0 0
antigen processing and presentation of peptide antigen via MHC class I -0.017 0.051 -10000 0 -10000 0 0
CaM/Ca2+ 0.036 0.053 -10000 0 -10000 0 0
RAP1A 0.003 0.081 -10000 0 -0.31 1 1
STAT1 (dimer)/SHP2 0.028 0.074 -10000 0 -10000 0 0
AKT1 -0.003 0.055 -10000 0 -10000 0 0
MAP2K1 -0.014 0.068 0.14 2 -10000 0 2
MAP3K11 0.005 0.071 0.14 3 -10000 0 3
IFNGR1 0.022 0.018 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKII 0.023 0.088 -10000 0 -10000 0 0
Rap1/GTP -0.029 0.031 -10000 0 -10000 0 0
CRKL/C3G 0.035 0.009 -10000 0 -10000 0 0
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TC-PTP 0.028 0.061 -10000 0 -10000 0 0
CEBPB 0.017 0.072 -10000 0 -10000 0 0
STAT3 0.001 0.08 -10000 0 -0.31 1 1
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 -0.021 0.26 -10000 0 -0.99 1 1
STAT1 0.004 0.075 0.14 3 -10000 0 3
CALM1 0.022 0.008 -10000 0 -10000 0 0
IFN-gamma (dimer) -0.011 0.084 -10000 0 -0.19 3 3
PIK3CA 0.025 0 -10000 0 -10000 0 0
STAT1 (dimer)/PIAS1 0.027 0.075 -10000 0 -10000 0 0
CEBPB/PTGES2/Cbp/p300 -0.005 0.05 -10000 0 -10000 0 0
mol:Ca2+ 0.031 0.053 -10000 0 -10000 0 0
MAPK3 0.008 0.073 -10000 0 -10000 0 0
STAT1 (dimer) 0.001 0.081 -10000 0 -10000 0 0
MAPK1 0.009 0.073 -10000 0 -10000 0 0
JAK2 0.019 0.016 -10000 0 -10000 0 0
PIK3R1 0.023 0.006 -10000 0 -10000 0 0
JAK1 0.02 0.018 -10000 0 -10000 0 0
CAMK2D 0.025 0 -10000 0 -10000 0 0
DAPK1 0.018 0.054 -10000 0 -10000 0 0
SMAD7 0.013 0.041 -10000 0 -10000 0 0
CBL/CRKL/C3G 0.037 0.071 -10000 0 -10000 0 0
PI3K 0.033 0.055 -10000 0 -10000 0 0
IFNG -0.011 0.084 -10000 0 -0.19 3 3
apoptosis -0.024 0.16 -10000 0 -0.41 2 2
CAMK2G 0.023 0.006 -10000 0 -10000 0 0
STAT3 (dimer) 0.001 0.08 -10000 0 -0.31 1 1
CAMK2A 0.023 0.006 -10000 0 -10000 0 0
CAMK2B -0.036 0.12 -10000 0 -0.27 3 3
FRAP1 -0.006 0.052 -10000 0 -10000 0 0
PRKCD 0 0.07 -10000 0 -10000 0 0
RAP1B 0.012 0.051 -10000 0 -0.19 1 1
negative regulation of cell growth -0.017 0.051 -10000 0 -10000 0 0
PTPN2 0.022 0.008 -10000 0 -10000 0 0
EP300 0.025 0.001 -10000 0 -10000 0 0
IRF1 -0.022 0.12 -10000 0 -0.34 1 1
STAT1 (dimer)/PIASy 0.027 0.079 -10000 0 -10000 0 0
SOCS1 -0.047 0.27 -10000 0 -1.1 1 1
mol:GDP 0.033 0.067 -10000 0 -10000 0 0
CASP1 0.003 0.057 -10000 0 -0.13 1 1
PTGES2 0.003 0.081 -10000 0 -0.31 1 1
IRF9 0.002 0.031 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 0.022 0.047 -10000 0 -10000 0 0
RAP1/GDP 0.006 0.055 -10000 0 -10000 0 0
CBL 0.004 0.07 0.14 3 -10000 0 3
MAP3K1 -0.011 0.07 0.14 2 -10000 0 2
PIAS1 0.025 0 -10000 0 -10000 0 0
PIAS4 0.025 0.002 -10000 0 -10000 0 0
antigen processing and presentation of peptide antigen via MHC class II -0.017 0.051 -10000 0 -10000 0 0
PTPN11 0.013 0.074 0.15 3 -10000 0 3
CREBBP 0.022 0.008 -10000 0 -10000 0 0
RAPGEF1 0.023 0.006 -10000 0 -10000 0 0
Class I PI3K signaling events mediated by Akt

Figure S71.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S71.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.011 0 -10000 0 -10000 0 0
BAD/BCL-XL/YWHAZ 0.028 0.05 -10000 0 -0.16 1 1
CDKN1B -0.006 0.061 -10000 0 -0.24 1 1
CDKN1A -0.015 0.067 -10000 0 -0.24 1 1
FRAP1 0.023 0.006 -10000 0 -10000 0 0
PRKDC 0.025 0 -10000 0 -10000 0 0
FOXO3 -0.004 0.061 -10000 0 -0.24 1 1
AKT1 -0.003 0.064 -10000 0 -0.25 1 1
BAD 0.004 0.081 -10000 0 -0.31 1 1
AKT3 0.011 0.004 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
FOXO4 -0.004 0.061 -10000 0 -0.24 1 1
AKT1/ASK1 0.003 0.08 -10000 0 -0.23 1 1
BAD/YWHAZ 0.037 0.056 -10000 0 -0.18 1 1
RICTOR 0.025 0 -10000 0 -10000 0 0
RAF1 0.025 0 -10000 0 -10000 0 0
JNK cascade -0.003 0.078 0.23 1 -10000 0 1
TSC1 -0.007 0.061 -10000 0 -0.24 1 1
YWHAZ 0.025 0 -10000 0 -10000 0 0
AKT1/RAF1 0.013 0.077 -10000 0 -0.24 1 1
EP300 0.025 0 -10000 0 -10000 0 0
mol:GDP -0.003 0.063 -10000 0 -0.25 1 1
mol:PI-3-4-5-P3 0 0 -10000 0 -10000 0 0
TSC2 -0.006 0.061 -10000 0 -0.24 1 1
YWHAQ 0.004 0.081 -10000 0 -0.31 1 1
TBC1D4 -0.017 0.046 -10000 0 -0.16 1 1
MAP3K5 0.004 0.081 -10000 0 -0.31 1 1
MAPKAP1 0.023 0.006 -10000 0 -10000 0 0
negative regulation of cell cycle -0.013 0.066 -10000 0 -10000 0 0
YWHAH 0.012 0.051 -10000 0 -0.19 1 1
AKT1S1 -0.015 0.067 -10000 0 -0.24 1 1
CASP9 -0.006 0.061 -10000 0 -0.24 1 1
YWHAB 0.025 0 -10000 0 -10000 0 0
p27Kip1/KPNA1 0.008 0.074 -10000 0 -0.23 1 1
GBL 0.022 0.008 -10000 0 -10000 0 0
PDK1/Src/Hsp90 0.03 0.011 -10000 0 -10000 0 0
YWHAE 0.022 0.008 -10000 0 -10000 0 0
SRC 0.025 0 -10000 0 -10000 0 0
AKT2/p21CIP1 -0.012 0.063 -10000 0 -10000 0 0
KIAA1303 0 0 -10000 0 -10000 0 0
mTOR/RHEB/GTP/Raptor/GBL 0.027 0.025 -10000 0 -10000 0 0
CHUK -0.015 0.067 -10000 0 -0.24 1 1
BAD/BCL-XL 0.008 0.083 -10000 0 -0.23 1 1
mTORC2 0.053 0.025 -10000 0 -10000 0 0
AKT2 0.006 0.018 -10000 0 -10000 0 0
FOXO1-3a-4/14-3-3 family 0.011 0.072 -10000 0 -10000 0 0
PDPK1 0.022 0.008 -10000 0 -10000 0 0
MDM2 0.016 0.088 0.19 1 -0.24 1 2
MAPKKK cascade -0.013 0.076 0.24 1 -10000 0 1
MDM2/Cbp/p300 0.038 0.088 -10000 0 -10000 0 0
TSC1/TSC2 -0.009 0.059 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.036 0.084 -10000 0 -10000 0 0
glucose import -0.036 0.051 -10000 0 -10000 0 0
mTOR/RHEB/GDP/Raptor/GBL/PRAS40 0.023 0.052 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
SLC2A4 -0.036 0.051 -10000 0 -0.15 1 1
GSK3A -0.006 0.061 -10000 0 -0.24 1 1
FOXO1 -0.004 0.061 -10000 0 -0.24 1 1
GSK3B -0.006 0.061 -10000 0 -0.24 1 1
SFN -0.001 0.07 -10000 0 -0.19 2 2
G1/S transition of mitotic cell cycle -0.002 0.067 -10000 0 -0.24 1 1
p27Kip1/14-3-3 family 0.021 0.077 -10000 0 -10000 0 0
PRKACA 0.025 0 -10000 0 -10000 0 0
KPNA1 0.004 0.081 -10000 0 -0.31 1 1
HSP90AA1 0 0 -10000 0 -10000 0 0
YWHAG 0.019 0.011 -10000 0 -10000 0 0
RHEB 0.019 0.011 -10000 0 -10000 0 0
CREBBP 0.022 0.008 -10000 0 -10000 0 0
Nectin adhesion pathway

Figure S72.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S72.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.023 0.006 -9999 0 -10000 0 0
alphaV beta3 Integrin -0.01 0.1 -9999 0 -0.22 3 3
PTK2 -0.008 0.074 -9999 0 -10000 0 0
positive regulation of JNK cascade -0.002 0.082 -9999 0 -10000 0 0
CDC42/GDP 0.009 0.11 -9999 0 -0.37 1 1
Rac1/GDP -0.001 0.11 -9999 0 -0.38 1 1
RAP1B 0.012 0.051 -9999 0 -0.19 1 1
RAP1A 0.003 0.081 -9999 0 -0.31 1 1
CTNNB1 -0.018 0.11 -9999 0 -0.31 2 2
CDC42/GTP -0.002 0.099 -9999 0 -10000 0 0
nectin-3/I-afadin 0.022 0.061 -9999 0 -0.21 1 1
RAPGEF1 0.006 0.089 -9999 0 -0.32 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.008 0.1 -9999 0 -0.36 1 1
PDGFB-D/PDGFRB 0.023 0.006 -9999 0 -10000 0 0
TLN1 -0.018 0.058 -9999 0 -0.24 1 1
Rap1/GTP 0.001 0.067 -9999 0 -0.24 1 1
IQGAP1 0.025 0 -9999 0 -10000 0 0
Rap1/GTP/I-afadin 0.023 0.06 -9999 0 -0.16 1 1
nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin 0.022 0.061 -9999 0 -0.21 1 1
PVR 0.025 0 -9999 0 -10000 0 0
Necl-5(dimer) 0.025 0 -9999 0 -10000 0 0
mol:GDP -0.002 0.13 -9999 0 -0.45 1 1
MLLT4 0.025 0 -9999 0 -10000 0 0
PIK3CA 0.025 0 -9999 0 -10000 0 0
PI3K 0.056 0.058 -9999 0 -0.16 1 1
nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin 0.027 0.039 -9999 0 -0.13 1 1
positive regulation of lamellipodium assembly -0.006 0.093 -9999 0 -0.36 1 1
PVRL1 0.012 0.051 -9999 0 -0.19 1 1
PVRL3 0.004 0.081 -9999 0 -0.31 1 1
PVRL2 0.025 0 -9999 0 -10000 0 0
PIK3R1 0.023 0.006 -9999 0 -10000 0 0
CDH1 -0.024 0.1 -9999 0 -0.23 3 3
CLDN1 0.004 0.081 -9999 0 -0.31 1 1
JAM-A/CLDN1 0.032 0.076 -9999 0 -0.16 2 2
SRC 0.004 0.1 -9999 0 -0.39 1 1
ITGB3 -0.022 0.1 -9999 0 -0.23 3 3
nectin-1(dimer)/I-afadin/I-afadin 0.027 0.039 -9999 0 -0.13 1 1
FARP2 -0.011 0.13 -9999 0 -0.38 1 1
RAC1 0.019 0.011 -9999 0 -10000 0 0
CTNNA1 0.023 0.006 -9999 0 -10000 0 0
nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) 0.037 0.056 -9999 0 -0.18 1 1
nectin-1/I-afadin 0.027 0.039 -9999 0 -0.13 1 1
nectin-2/I-afadin 0.037 0 -9999 0 -10000 0 0
RAC1/GTP/IQGAP1/filamentous actin 0.025 0.015 -9999 0 -10000 0 0
nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin 0.031 0.077 -9999 0 -0.27 1 1
CDC42/GTP/IQGAP1/filamentous actin 0.032 0.008 -9999 0 -10000 0 0
F11R 0.023 0.006 -9999 0 -10000 0 0
positive regulation of filopodium formation -0.002 0.082 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Talin -0.026 0.1 -9999 0 -0.25 2 2
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0 -9999 0 -10000 0 0
nectin-2(dimer)/I-afadin/I-afadin 0.037 0 -9999 0 -10000 0 0
PIP5K1C -0.012 0.062 -9999 0 -0.25 1 1
VAV2 -0.005 0.16 -9999 0 -0.64 1 1
RAP1/GDP 0.008 0.098 -9999 0 -0.34 1 1
ITGAV 0.004 0.081 -9999 0 -0.31 1 1
nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin 0.037 0.056 -9999 0 -0.18 1 1
nectin-3(dimer)/I-afadin/I-afadin 0.022 0.061 -9999 0 -0.21 1 1
Rac1/GTP -0.008 0.11 -9999 0 -0.44 1 1
PTPRM -0.008 0.07 -9999 0 -0.28 1 1
E-cadherin/beta catenin/alpha catenin 0.007 0.091 -9999 0 -0.16 1 1
adherens junction assembly 0 0 -9999 0 -10000 0 0
CDC42 0.023 0.006 -9999 0 -10000 0 0
Glucocorticoid receptor regulatory network

Figure S73.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S73.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PCK2 0.032 0.066 -10000 0 -10000 0 0
SMARCC2 0.025 0 -10000 0 -10000 0 0
SMARCC1 0.025 0 -10000 0 -10000 0 0
TBX21 -0.065 0.16 -10000 0 -0.63 1 1
SUMO2 0.018 0.019 -10000 0 -10000 0 0
STAT1 (dimer) 0.012 0.055 -10000 0 -0.18 1 1
FKBP4 0.025 0 -10000 0 -10000 0 0
FKBP5 -0.009 0.093 -10000 0 -0.25 2 2
GR alpha/HSP90/FKBP51/HSP90 0.025 0.08 0.26 1 -10000 0 1
PRL -0.028 0.1 -10000 0 -10000 0 0
cortisol/GR alpha (dimer)/TIF2 0.065 0.18 0.56 1 -10000 0 1
RELA -0.023 0.089 -10000 0 -0.23 1 1
FGG 0.033 0.17 0.46 1 -10000 0 1
GR beta/TIF2 0.036 0.093 0.29 1 -10000 0 1
IFNG -0.065 0.15 -10000 0 -10000 0 0
apoptosis -0.038 0.2 0.5 1 -10000 0 1
CREB1 0.032 0 -10000 0 -10000 0 0
histone acetylation -0.014 0.073 -10000 0 -0.2 1 1
BGLAP -0.016 0.089 -10000 0 -10000 0 0
GR/PKAc 0.068 0.081 0.28 1 -10000 0 1
NF kappa B1 p50/RelA -0.056 0.15 -10000 0 -0.3 3 3
SMARCD1 0.025 0 -10000 0 -10000 0 0
MDM2 0.021 0.067 0.23 1 -10000 0 1
GATA3 0.02 0.051 -10000 0 -0.18 1 1
AKT1 0.018 0.007 -10000 0 -10000 0 0
CSF2 -0.13 0.32 -10000 0 -0.96 2 2
GSK3B 0.018 0.021 -10000 0 -10000 0 0
NR1I3 -0.062 0.24 0.46 1 -0.72 1 2
CSN2 0.033 0.13 0.38 1 -10000 0 1
BRG1/BAF155/BAF170/BAF60A 0.057 0.021 -10000 0 -10000 0 0
NFATC1 0.007 0.087 -10000 0 -0.33 1 1
POU2F1 0.028 0.007 -10000 0 -10000 0 0
CDKN1A -0.065 0.29 -10000 0 -1.1 1 1
response to stress 0 0 -10000 0 -10000 0 0
response to UV -0.001 0.009 -10000 0 -10000 0 0
SFN -0.001 0.07 -10000 0 -0.19 2 2
GR alpha/HSP90/FKBP51/HSP90/14-3-3 0.036 0.084 0.26 1 -10000 0 1
prolactin receptor activity 0 0 -10000 0 -10000 0 0
EGR1 -0.09 0.28 0.45 1 -0.7 2 3
JUN -0.039 0.082 -10000 0 -10000 0 0
IL4 -0.067 0.23 -10000 0 -0.89 1 1
CDK5R1 0.025 0.004 -10000 0 -10000 0 0
PRKACA 0.025 0 -10000 0 -10000 0 0
cortisol/GR alpha (monomer)/AP-1 -0.058 0.054 -10000 0 -10000 0 0
GR alpha/HSP90/FKBP51/HSP90/PP5C 0.032 0.093 0.26 1 -0.17 1 2
cortisol/GR alpha (monomer) 0.065 0.2 0.65 1 -10000 0 1
NCOA2 0.025 0 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
FOS -0.032 0.12 -10000 0 -0.27 3 3
AP-1/NFAT1-c-4 -0.046 0.12 -10000 0 -10000 0 0
AFP -0.036 0.07 -10000 0 -10000 0 0
SUV420H1 0.025 0 -10000 0 -10000 0 0
IRF1 0.038 0.11 0.35 1 -10000 0 1
TP53 -0.014 0.14 -10000 0 -0.37 2 2
PPP5C 0.004 0.081 -10000 0 -0.31 1 1
KRT17 -0.055 0.13 -10000 0 -10000 0 0
KRT14 -0.048 0.1 -10000 0 -10000 0 0
TBP 0.032 0 -10000 0 -10000 0 0
CREBBP 0.024 0.024 -10000 0 -10000 0 0
HDAC1 0.019 0.005 -10000 0 -10000 0 0
HDAC2 0.034 0.026 -10000 0 -10000 0 0
AP-1 -0.046 0.12 -10000 0 -10000 0 0
MAPK14 0.018 0.02 -10000 0 -10000 0 0
MAPK10 -0.016 0.088 -10000 0 -0.23 2 2
MAPK11 -0.003 0.082 -10000 0 -0.31 1 1
KRT5 -0.045 0.13 -10000 0 -10000 0 0
interleukin-1 receptor activity 0.008 0.026 -10000 0 -10000 0 0
NCOA1 0.027 0.001 -10000 0 -10000 0 0
STAT1 0.012 0.055 -10000 0 -0.18 1 1
CGA -0.016 0.089 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/Cbp/cortisol/GR alpha (monomer)/HDAC2 0.057 0.18 0.52 2 -10000 0 2
MAPK3 0.015 0.021 -10000 0 -10000 0 0
MAPK1 0.018 0.02 -10000 0 -10000 0 0
ICAM1 -0.072 0.16 -10000 0 -0.42 2 2
NFKB1 -0.044 0.11 -10000 0 -0.26 2 2
MAPK8 -0.03 0.11 -10000 0 -0.28 2 2
MAPK9 -0.005 0.082 -10000 0 -0.31 1 1
cortisol/GR alpha (dimer) -0.04 0.2 0.5 1 -10000 0 1
BAX -0.015 0.11 -10000 0 -10000 0 0
POMC -0.031 0.11 -10000 0 -10000 0 0
EP300 0.031 0.035 -10000 0 -10000 0 0
cortisol/GR alpha (dimer)/p53 0.02 0.11 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.008 0.053 0.16 1 -10000 0 1
SGK1 0.037 0.059 0.2 1 -10000 0 1
IL13 -0.037 0.11 -10000 0 -10000 0 0
IL6 -0.12 0.26 -10000 0 -0.72 2 2
PRKACG 0.023 0.006 -10000 0 -10000 0 0
IL5 -0.031 0.099 -10000 0 -10000 0 0
IL2 -0.051 0.14 -10000 0 -10000 0 0
CDK5 0.018 0.011 -10000 0 -10000 0 0
PRKACB 0.023 0.006 -10000 0 -10000 0 0
HSP90AA1 0 0 -10000 0 -10000 0 0
IL8 -0.23 0.38 -10000 0 -0.87 4 4
CDK5R1/CDK5 0.021 0.025 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/PKAc -0.015 0.13 -10000 0 -0.31 1 1
cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 0.064 0.17 0.53 1 -10000 0 1
SMARCA4 0.022 0.008 -10000 0 -10000 0 0
chromatin remodeling 0.032 0.099 0.35 1 -10000 0 1
NF kappa B1 p50/RelA/Cbp -0.021 0.13 -10000 0 -0.33 1 1
JUN (dimer) -0.039 0.082 -10000 0 -10000 0 0
YWHAH 0.012 0.051 -10000 0 -0.19 1 1
VIPR1 -0.016 0.084 -10000 0 -0.29 1 1
NR3C1 0.036 0.13 0.42 1 -10000 0 1
NR4A1 0.017 0.051 -10000 0 -0.18 1 1
TIF2/SUV420H1 0.037 0 -10000 0 -10000 0 0
MAPKKK cascade -0.038 0.2 0.5 1 -10000 0 1
cortisol/GR alpha (dimer)/Src-1 0.068 0.18 0.57 1 -10000 0 1
PBX1 -0.014 0.11 -10000 0 -0.3 2 2
POU1F1 0.03 0 -10000 0 -10000 0 0
SELE -0.087 0.24 -10000 0 -0.64 2 2
cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A 0.032 0.099 0.35 1 -10000 0 1
cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 0.064 0.17 0.53 1 -10000 0 1
mol:cortisol 0.026 0.12 0.4 1 -10000 0 1
MMP1 0 0.052 -10000 0 -10000 0 0
Paxillin-independent events mediated by a4b1 and a4b7

Figure S74.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S74.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.012 0.069 -9999 0 -0.24 1 1
CRKL 0.025 0 -9999 0 -10000 0 0
Rac1/GDP 0.014 0.008 -9999 0 -10000 0 0
DOCK1 0.023 0.006 -9999 0 -10000 0 0
ITGA4 -0.009 0.093 -9999 0 -0.25 2 2
alpha4/beta7 Integrin/MAdCAM1 0.005 0.09 -9999 0 -0.16 2 2
EPO 0.019 0.011 -9999 0 -10000 0 0
alpha4/beta7 Integrin 0.001 0.077 -9999 0 -0.16 3 3
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.022 0.008 -9999 0 -10000 0 0
alpha4/beta1 Integrin 0.009 0.07 -9999 0 -0.17 2 2
EPO/EPOR (dimer) 0.018 0.04 -9999 0 -0.13 1 1
lamellipodium assembly -0.034 0.14 -9999 0 -0.39 2 2
PIK3CA 0.025 0 -9999 0 -10000 0 0
PI3K 0.035 0.009 -9999 0 -10000 0 0
ARF6 0.022 0.008 -9999 0 -10000 0 0
JAK2 0.009 0.019 -9999 0 -10000 0 0
PXN 0.025 0 -9999 0 -10000 0 0
PIK3R1 0.023 0.006 -9999 0 -10000 0 0
MADCAM1 0.012 0.051 -9999 0 -0.19 1 1
cell adhesion 0.004 0.088 -9999 0 -0.16 2 2
CRKL/CBL 0.037 0 -9999 0 -10000 0 0
ITGB1 0.023 0.006 -9999 0 -10000 0 0
SRC -0.051 0.061 -9999 0 -0.16 3 3
ITGB7 0.012 0.051 -9999 0 -0.19 1 1
RAC1 0.019 0.011 -9999 0 -10000 0 0
alpha4/beta1 Integrin/VCAM1 -0.018 0.093 -9999 0 -0.18 3 3
p130Cas/Crk/Dock1 -0.025 0.071 -9999 0 -10000 0 0
VCAM1 -0.031 0.12 -9999 0 -0.27 3 3
RHOA 0.004 0.081 -9999 0 -0.31 1 1
alpha4/beta1 Integrin/Paxillin/GIT1 0.036 0.066 -9999 0 -0.16 1 1
BCAR1 -0.05 0.058 -9999 0 -10000 0 0
EPOR 0.012 0.051 -9999 0 -0.19 1 1
mol:GDP 0 0 -9999 0 -10000 0 0
CBL 0.025 0 -9999 0 -10000 0 0
GIT1 0.025 0 -9999 0 -10000 0 0
Rac1/GTP -0.035 0.15 -9999 0 -0.4 2 2
Signaling events mediated by HDAC Class III

Figure S75.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S75.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.025 0 -10000 0 -10000 0 0
HDAC4 0.023 0.006 -10000 0 -10000 0 0
induction of apoptosis 0 0 -10000 0 -10000 0 0
regulation of S phase of mitotic cell cycle -0.001 0.031 -10000 0 -0.12 1 1
CDKN1A -0.035 0.13 -10000 0 -0.53 1 1
KAT2B 0 0 -10000 0 -10000 0 0
BAX 0.025 0 -10000 0 -10000 0 0
FOXO3 -0.005 0.009 -10000 0 -10000 0 0
FOXO1 0 0 -10000 0 -10000 0 0
FOXO4 0.007 0.003 -10000 0 -10000 0 0
response to UV 0 0 -10000 0 -10000 0 0
XRCC6 0.025 0 -10000 0 -10000 0 0
TAT 0.023 0.006 -10000 0 -10000 0 0
mol:Lysophosphatidic acid 0 0 -10000 0 -10000 0 0
MYOD1 -0.012 0.028 -10000 0 -0.12 1 1
PPARGC1A -0.017 0.11 -10000 0 -0.31 2 2
FHL2 0.025 0 -10000 0 -10000 0 0
response to nutrient levels 0 0 -10000 0 -10000 0 0
KU70/SIRT1 0.04 0.029 0.15 1 -10000 0 1
HIST2H4A 0.001 0.031 0.12 1 -10000 0 1
SIRT1/FOXO3a 0.021 0.028 -10000 0 -10000 0 0
SIRT1 0.03 0.039 0.18 1 -10000 0 1
response to hypoxia 0 0 -10000 0 -10000 0 0
SIRT1/MEF2D/HDAC4 0.049 0.031 -10000 0 -10000 0 0
SIRT1/Histone H1b 0.036 0.033 -10000 0 -10000 0 0
apoptosis -0.052 0.028 -10000 0 -10000 0 0
SIRT1/PGC1A 0.01 0.076 0.13 1 -0.18 2 3
p53/SIRT1 0.031 0.1 0.34 1 -0.22 1 2
SIRT1/FOXO4 0.033 0.033 0.14 1 -10000 0 1
FOXO1/FHL2/SIRT1 0.034 0.025 0.13 1 -10000 0 1
HIST1H1E 0.011 0.004 -10000 0 -10000 0 0
SIRT1/p300 0.04 0.029 0.15 1 -10000 0 1
muscle cell differentiation -0.012 0.039 0.1 1 -0.12 1 2
TP53 0.01 0.092 0.18 1 -0.31 1 2
KU70/SIRT1/BAX 0.052 0.028 -10000 0 -10000 0 0
CREBBP 0.022 0.008 -10000 0 -10000 0 0
MEF2D 0.023 0.006 -10000 0 -10000 0 0
HIV-1 Tat/SIRT1 0.038 0.031 0.15 1 -10000 0 1
ACSS2 -0.003 0.033 0.12 1 -10000 0 1
SIRT1/PCAF/MYOD 0.012 0.04 0.12 1 -0.1 1 2
IL1-mediated signaling events

Figure S76.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S76.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
UBC13/UEV1A 0.019 0 -9999 0 -10000 0 0
PRKCZ 0 0 -9999 0 -10000 0 0
MAP3K7IP2 0.025 0 -9999 0 -10000 0 0
ERC1 0 0 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 -0.01 0.049 -9999 0 -10000 0 0
IRAK/TOLLIP 0.028 0 -9999 0 -10000 0 0
IKBKB 0.025 0 -9999 0 -10000 0 0
IKBKG 0.025 0 -9999 0 -10000 0 0
IL1 alpha/IL1R2 0.017 0.054 -9999 0 -0.13 2 2
IL1A -0.001 0.07 -9999 0 -0.19 2 2
IL1B -0.077 0.09 -9999 0 -0.19 6 6
IRAK/TRAF6/p62/Atypical PKCs 0.043 0.016 -9999 0 -10000 0 0
IL1R2 0.025 0 -9999 0 -10000 0 0
IL1R1 0.025 0 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.002 0.029 -9999 0 -10000 0 0
TOLLIP 0.025 0 -9999 0 -10000 0 0
TICAM2 0 0 -9999 0 -10000 0 0
MAP3K3 0.009 0.051 -9999 0 -0.19 1 1
TAK1/TAB1/TAB2 0.048 0.012 -9999 0 -10000 0 0
IKK complex/ELKS -0.003 0.065 -9999 0 -0.25 1 1
JUN -0.036 0.037 -9999 0 -10000 0 0
MAP3K7 0.025 0 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/PI3K -0.014 0.097 -9999 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88 0.044 0.054 -9999 0 -10000 0 0
PIK3R1 0.023 0.006 -9999 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 0.054 0.056 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP -0.029 0.092 -9999 0 -0.17 4 4
NFKB1 0.004 0.081 -9999 0 -0.31 1 1
MAPK8 -0.026 0.032 -9999 0 -10000 0 0
IRAK1 0.012 0 -9999 0 -10000 0 0
IL1RN/IL1R1 0.007 0.064 -9999 0 -0.13 3 3
IRAK4 0.025 0 -9999 0 -10000 0 0
PRKCI 0.025 0 -9999 0 -10000 0 0
TRAF6 0.023 0.006 -9999 0 -10000 0 0
PI3K 0.035 0.009 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.013 0.052 -9999 0 -10000 0 0
CHUK 0.003 0.081 -9999 0 -0.31 1 1
IL1 beta fragment/IL1R1/IL1RAP/MYD88s -0.029 0.092 -9999 0 -0.17 4 4
IL1 beta/IL1R2 -0.039 0.095 -9999 0 -0.18 4 4
IRAK/TRAF6/TAK1/TAB1/TAB2 0.055 0.021 -9999 0 -10000 0 0
NF kappa B1 p50/RelA -0.028 0.094 -9999 0 -10000 0 0
IRAK3 -0.017 0.11 -9999 0 -0.31 2 2
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 -0.018 0.09 -9999 0 -0.15 4 4
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP 0.019 0.021 -9999 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP 0.031 0.052 -9999 0 -10000 0 0
RELA 0.025 0 -9999 0 -10000 0 0
MAP3K7IP1 0.023 0.006 -9999 0 -10000 0 0
SQSTM1 0.023 0.006 -9999 0 -10000 0 0
MYD88 0.025 0 -9999 0 -10000 0 0
IRAK/TRAF6/MEKK3 0.029 0.034 -9999 0 -10000 0 0
IL1RAP 0.025 0 -9999 0 -10000 0 0
UBE2N 0.025 0 -9999 0 -10000 0 0
IRAK/TRAF6 -0.031 0.075 -9999 0 -10000 0 0
CASP1 -0.001 0.07 -9999 0 -0.19 2 2
IL1RN/IL1R2 0.007 0.064 -9999 0 -0.13 3 3
IL1 beta fragment/IL1R1/IL1RAP/MYD88 -0.017 0.096 -9999 0 -0.16 4 4
TMEM189-UBE2V1 0 0 -9999 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP 0.022 0.015 -9999 0 -10000 0 0
PIK3CA 0.025 0 -9999 0 -10000 0 0
IL1RN -0.015 0.082 -9999 0 -0.19 3 3
TRAF6/TAK1/TAB1/TAB2 0.054 0.021 -9999 0 -10000 0 0
MAP2K6 -0.016 0.006 -9999 0 -10000 0 0
Signaling events regulated by Ret tyrosine kinase

Figure S77.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S77.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.008 0.11 -10000 0 -0.42 1 1
Crk/p130 Cas/Paxillin 0 0.024 -10000 0 -10000 0 0
JUN -0.008 0.047 -10000 0 -10000 0 0
HRAS 0.025 0 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/GRB10 0.034 0.045 -10000 0 -10000 0 0
RAP1A 0.003 0.081 -10000 0 -0.31 1 1
FRS2 0.003 0.081 -10000 0 -0.31 1 1
RAP1A/GDP 0.003 0.055 -10000 0 -0.21 1 1
RET51/GFRalpha1/GDNF/DOK1 0.05 0.041 -10000 0 -10000 0 0
EntrezGene:5979 0 0 -10000 0 -10000 0 0
PTPN11 0.025 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.022 0.008 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/Enigma 0.033 0.037 -10000 0 -10000 0 0
RHOA 0.004 0.081 -10000 0 -0.31 1 1
RAP1A/GTP 0.027 0.061 -10000 0 -0.15 1 1
GRB7 0.023 0.006 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF 0.05 0.041 -10000 0 -10000 0 0
MAPKKK cascade 0.015 0.049 -10000 0 -10000 0 0
BCAR1 0.023 0.006 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/IRS1 0.028 0.047 -10000 0 -10000 0 0
lamellipodium assembly 0.009 0.022 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/SHC 0.046 0.043 -10000 0 -10000 0 0
PIK3CA 0.025 0 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC 0.037 0.036 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/Shank3 0.026 0.06 -10000 0 -0.16 1 1
MAPK3 -0.017 0.059 0.16 1 -10000 0 1
DOK1 0.025 0 -10000 0 -10000 0 0
DOK6 -0.031 0.12 -10000 0 -0.27 3 3
PXN 0.025 0 -10000 0 -10000 0 0
neurite development -0.021 0.048 -10000 0 -10000 0 0
DOK5 -0.058 0.14 -10000 0 -0.31 4 4
GFRA1 0.012 0.051 -10000 0 -0.19 1 1
MAPK8 0.001 0.037 -10000 0 -10000 0 0
HRAS/GTP 0.046 0.037 -10000 0 -10000 0 0
tube development 0.042 0.082 0.2 2 -0.15 1 3
MAPK1 -0.007 0.074 0.16 2 -10000 0 2
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 0.003 0.048 -10000 0 -0.17 1 1
Rac1/GDP 0.014 0.008 -10000 0 -10000 0 0
SRC 0.025 0 -10000 0 -10000 0 0
PDLIM7 0.022 0.008 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok6 0.03 0.075 -10000 0 -0.16 1 1
SHC1 0.023 0.006 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok4 0.046 0.043 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok5 -0.007 0.1 -10000 0 -0.16 4 4
PRKCA 0.022 0.008 -10000 0 -10000 0 0
HRAS/GDP 0.019 0 -10000 0 -10000 0 0
CREB1 0.018 0.014 -10000 0 -10000 0 0
PIK3R1 0.023 0.006 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 0.016 0.016 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/Grb7 0.046 0.043 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
RET 0.023 0.006 -10000 0 -10000 0 0
DOK4 0.023 0.006 -10000 0 -10000 0 0
JNK cascade -0.008 0.047 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/FRS2 0.023 0.06 -10000 0 -0.16 1 1
SHANK3 0.004 0.081 -10000 0 -0.31 1 1
RASA1 0.023 0.006 -10000 0 -10000 0 0
NCK1 0.025 0 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 0.015 0.016 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 0.005 0.049 -10000 0 -0.17 1 1
RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK 0.019 0.017 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 0.018 0.017 -10000 0 -10000 0 0
PI3K 0.018 0.042 -10000 0 -10000 0 0
SOS1 0.025 0 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/Shank3/Grb2 0.029 0.062 -10000 0 -0.15 1 1
GRB10 0.019 0.011 -10000 0 -10000 0 0
activation of MAPKK activity 0.017 0.057 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/FRS2 0.032 0.066 -10000 0 -0.16 1 1
GAB1 0.025 0 -10000 0 -10000 0 0
IRS1 0.01 0.051 -10000 0 -0.19 1 1
IRS2 0.025 0 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 0.018 0.017 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/PKC alpha 0.042 0.044 -10000 0 -10000 0 0
GRB2 0.022 0.008 -10000 0 -10000 0 0
PRKACA 0.025 0 -10000 0 -10000 0 0
GDNF 0.025 0 -10000 0 -10000 0 0
RAC1 0.019 0.011 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/IRS1 0.036 0.055 -10000 0 -10000 0 0
Rac1/GTP 0.019 0.035 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF 0.025 0.033 -10000 0 -0.1 1 1
GFRalpha1/GDNF 0.027 0.039 -10000 0 -0.13 1 1
S1P5 pathway

Figure S78.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S78.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -9999 0 -10000 0 0
telencephalon oligodendrocyte cell migration -0.017 0.069 -9999 0 -10000 0 0
GNAI2 0.025 0 -9999 0 -10000 0 0
S1P/S1P5/G12 0.013 0.007 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
GNAO1 0.023 0.006 -9999 0 -10000 0 0
RhoA/GTP 0.018 0.07 -9999 0 -10000 0 0
negative regulation of cAMP metabolic process 0.019 0.061 -9999 0 -0.15 1 1
GNAZ 0.025 0 -9999 0 -10000 0 0
GNAI3 0.023 0.006 -9999 0 -10000 0 0
GNA12 0.019 0.011 -9999 0 -10000 0 0
S1PR5 0 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
S1P/S1P5/Gi -0.004 0.045 -9999 0 -0.15 1 1
RhoA/GDP 0.004 0.055 -9999 0 -0.21 1 1
RHOA 0.004 0.081 -9999 0 -0.31 1 1
GNAI1 -0.002 0.08 -9999 0 -0.31 1 1
ceramide signaling pathway

Figure S79.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S79.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K4 -0.053 0.14 -9999 0 -0.5 1 1
BAG4 0.025 0 -9999 0 -10000 0 0
BAD -0.03 0.063 -9999 0 -0.18 2 2
NFKBIA 0.023 0.006 -9999 0 -10000 0 0
BIRC3 -0.051 0.13 -9999 0 -0.28 4 4
BAX -0.022 0.047 -9999 0 -0.15 1 1
EnzymeConsortium:3.1.4.12 -0.01 0.034 -9999 0 -0.11 1 1
IKBKB -0.048 0.14 -9999 0 -0.48 1 1
MAP2K2 -0.026 0.044 -9999 0 -10000 0 0
MAP2K1 -0.026 0.044 -9999 0 -10000 0 0
SMPD1 -0.019 0.049 -9999 0 -0.13 2 2
GO:0005551 0 0 -9999 0 -10000 0 0
FADD/Caspase 8 -0.048 0.14 -9999 0 -0.49 1 1
MAP2K4 -0.031 0.066 -9999 0 -0.26 1 1
protein ubiquitination -0.052 0.14 -9999 0 -0.49 1 1
EnzymeConsortium:2.7.1.37 -0.029 0.05 -9999 0 -0.18 1 1
response to UV 0 0 -9999 0 -10000 0 0
RAF1 -0.024 0.046 -9999 0 -0.15 1 1
CRADD 0.004 0.081 -9999 0 -0.31 1 1
mol:ceramide -0.02 0.049 -9999 0 -0.16 1 1
I-kappa-B-alpha/RELA/p50/ubiquitin 0.032 0.008 -9999 0 -10000 0 0
MADD 0.023 0.006 -9999 0 -10000 0 0
MAP3K1 -0.03 0.07 -9999 0 -0.27 1 1
TRADD 0.023 0.006 -9999 0 -10000 0 0
RELA/p50 0.025 0 -9999 0 -10000 0 0
MAPK3 -0.023 0.042 -9999 0 -10000 0 0
MAPK1 -0.022 0.043 -9999 0 -10000 0 0
p50/RELA/I-kappa-B-alpha 0.035 0.009 -9999 0 -10000 0 0
FADD -0.053 0.14 -9999 0 -0.5 1 1
KSR1 -0.022 0.048 -9999 0 -0.15 1 1
MAPK8 -0.04 0.061 -9999 0 -0.24 1 1
TRAF2 0.024 0.006 -9999 0 -10000 0 0
response to radiation 0 0 -9999 0 -10000 0 0
CHUK -0.057 0.14 -9999 0 -0.48 1 1
TNF R/SODD 0.037 0 -9999 0 -10000 0 0
TNF 0.012 0.051 -9999 0 -0.19 1 1
CYCS -0.004 0.065 -9999 0 -0.14 1 1
IKBKG -0.048 0.14 -9999 0 -0.48 1 1
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD -0.052 0.15 -9999 0 -0.52 1 1
RELA 0.025 0 -9999 0 -10000 0 0
RIPK1 0.025 0.001 -9999 0 -10000 0 0
AIFM1 -0.021 0.05 -9999 0 -0.14 1 1
TNF/TNF R/SODD 0.041 0.038 -9999 0 -10000 0 0
TNFRSF1A 0.025 0.001 -9999 0 -10000 0 0
response to heat 0 0 -9999 0 -10000 0 0
CASP8 0.014 0.033 -9999 0 -10000 0 0
NSMAF -0.052 0.14 -9999 0 -0.49 1 1
response to hydrogen peroxide 0 0 -9999 0 -10000 0 0
BCL2 0.001 0.08 -9999 0 -0.31 1 1
RXR and RAR heterodimerization with other nuclear receptor

Figure S80.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S80.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.017 0.077 -10000 0 -10000 0 0
VDR -0.001 0.07 -10000 0 -0.19 2 2
FAM120B 0 0 -10000 0 -10000 0 0
RXRs/LXRs/DNA/9cRA 0.017 0.05 -10000 0 -10000 0 0
RXRs/LXRs/DNA/Oxysterols 0.027 0.055 -10000 0 -10000 0 0
MED1 0 0 -10000 0 -10000 0 0
mol:9cRA 0.003 0.004 -10000 0 -10000 0 0
RARs/THRs/DNA/Src-1 0.012 0.048 -10000 0 -10000 0 0
RXRs/NUR77 0.043 0.056 -10000 0 -10000 0 0
RXRs/PPAR 0.016 0.039 -10000 0 -10000 0 0
NCOR2 0.025 0 -10000 0 -10000 0 0
VDR/VDR/Vit D3 0.001 0.046 -10000 0 -0.12 2 2
RARs/VDR/DNA/Vit D3 0.037 0.05 -10000 0 -10000 0 0
RARA 0.023 0.006 -10000 0 -10000 0 0
NCOA1 0.025 0 -10000 0 -10000 0 0
VDR/VDR/DNA -0.001 0.07 -10000 0 -0.19 2 2
RARs/RARs/DNA/9cRA 0.044 0.012 -10000 0 -10000 0 0
RARG 0.025 0 -10000 0 -10000 0 0
RPS6KB1 0.039 0.13 0.53 1 -10000 0 1
RARs/THRs/DNA/SMRT 0.012 0.048 -10000 0 -0.17 1 1
THRA 0.003 0.081 -10000 0 -0.31 1 1
mol:Bile acids 0 0 -10000 0 -10000 0 0
VDR/Vit D3/DNA 0.001 0.046 -10000 0 -0.12 2 2
RXRs/PPAR/9cRA/PGJ2/DNA 0.04 0.044 -10000 0 -10000 0 0
NR1H4 0.004 0.081 -10000 0 -0.31 1 1
RXRs/LXRs/DNA 0.048 0.076 -10000 0 -10000 0 0
NR1H2 0.026 0.011 -10000 0 -10000 0 0
NR1H3 0.004 0.081 -10000 0 -0.3 1 1
RXRs/VDR/DNA/Vit D3 0.035 0.065 -10000 0 -0.16 1 1
NR4A1 0.012 0.051 -10000 0 -0.19 1 1
mol:ATRA 0 0 -10000 0 -10000 0 0
RXRs/FXR/9cRA/MED1 -0.001 0.065 -10000 0 -0.25 1 1
RXRG 0.011 0.052 -10000 0 -0.18 1 1
RXR alpha/CCPG 0.019 0.006 -10000 0 -10000 0 0
RXRA 0.024 0.013 -10000 0 -10000 0 0
RXRB 0.026 0.012 -10000 0 -10000 0 0
THRB 0.025 0 -10000 0 -10000 0 0
PPARG 0.012 0.051 -10000 0 -0.19 1 1
PPARD 0.025 0 -10000 0 -10000 0 0
TNF 0.018 0.057 -10000 0 -10000 0 0
mol:Oxysterols 0.003 0.003 -10000 0 -10000 0 0
cholesterol transport 0.027 0.055 -10000 0 -10000 0 0
PPARA 0.025 0 -10000 0 -10000 0 0
mol:Vit D3 0 0 -10000 0 -10000 0 0
RARB 0.023 0.006 -10000 0 -10000 0 0
RXRs/NUR77/BCL2 -0.007 0.073 -10000 0 -0.27 1 1
SREBF1 0.015 0.045 -10000 0 -10000 0 0
RXRs/RXRs/DNA/9cRA 0.04 0.044 -10000 0 -10000 0 0
ABCA1 0.03 0.032 -10000 0 -10000 0 0
RARs/THRs 0.056 0.058 -10000 0 -0.16 1 1
RXRs/FXR 0.044 0.065 -10000 0 -10000 0 0
BCL2 0.001 0.08 -10000 0 -0.31 1 1
HIF-2-alpha transcription factor network

Figure S81.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S81.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MMP14 0.01 0.13 -9999 0 -0.48 1 1
oxygen homeostasis 0 0.01 -9999 0 -10000 0 0
TCEB2 0.022 0.008 -9999 0 -10000 0 0
TCEB1 0.025 0 -9999 0 -10000 0 0
VHL/Elongin B/Elongin C/HIF2A 0.028 0.072 -9999 0 -10000 0 0
EPO 0.001 0.094 -9999 0 -10000 0 0
FIH (dimer) 0.017 0.022 -9999 0 -10000 0 0
APEX1 0.012 0.028 -9999 0 -10000 0 0
SERPINE1 -0.011 0.11 -9999 0 -10000 0 0
FLT1 0.012 0.07 -9999 0 -10000 0 0
ADORA2A 0.011 0.11 -9999 0 -10000 0 0
germ cell development 0.024 0.11 -9999 0 -10000 0 0
SLC11A2 0.024 0.12 -9999 0 -10000 0 0
BHLHE40 0.019 0.11 -9999 0 -10000 0 0
HIF1AN 0.017 0.022 -9999 0 -10000 0 0
HIF2A/ARNT/SIRT1 0.04 0.09 -9999 0 -10000 0 0
ETS1 0.023 0.023 -9999 0 -10000 0 0
CITED2 -0.013 0.16 -9999 0 -0.62 1 1
KDR 0.024 0.055 -9999 0 -10000 0 0
PGK1 0.012 0.14 -9999 0 -10000 0 0
SIRT1 0.024 0.006 -9999 0 -10000 0 0
response to hypoxia 0 0 -9999 0 -10000 0 0
HIF2A/ARNT 0.055 0.14 -9999 0 -10000 0 0
EPAS1 0.012 0.056 -9999 0 -10000 0 0
SP1 0.03 0.001 -9999 0 -10000 0 0
ABCG2 0.024 0.12 -9999 0 -10000 0 0
EFNA1 0.013 0.14 -9999 0 -10000 0 0
FXN 0.016 0.1 -9999 0 -10000 0 0
POU5F1 0.024 0.12 -9999 0 -10000 0 0
neuron apoptosis -0.053 0.14 -9999 0 -10000 0 0
EP300 0.025 0 -9999 0 -10000 0 0
EGLN3 0.004 0.056 -9999 0 -0.2 1 1
EGLN2 0.015 0.025 -9999 0 -10000 0 0
EGLN1 0.017 0.022 -9999 0 -10000 0 0
VHL/Elongin B/Elongin C 0.045 0.017 -9999 0 -10000 0 0
VHL 0.025 0 -9999 0 -10000 0 0
ARNT 0.017 0.024 -9999 0 -10000 0 0
SLC2A1 0.013 0.11 -9999 0 -10000 0 0
TWIST1 -0.011 0.092 -9999 0 -10000 0 0
ELK1 0.004 0.085 -9999 0 -0.32 1 1
HIF2A/ARNT/Cbp/p300 0.039 0.096 -9999 0 -10000 0 0
VEGFA 0.019 0.11 -9999 0 -10000 0 0
CREBBP 0.022 0.008 -9999 0 -10000 0 0
Role of Calcineurin-dependent NFAT signaling in lymphocytes

Figure S82.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S82.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.025 0 -10000 0 -10000 0 0
NFATC1 0.015 0.052 -10000 0 -10000 0 0
NFATC2 -0.011 0.044 -10000 0 -10000 0 0
NFATC3 0.008 0.004 -10000 0 -10000 0 0
YWHAE 0.022 0.008 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/CABIN1 0.01 0.078 -10000 0 -0.25 1 1
Exportin 1/Ran/NUP214 0.048 0.012 -10000 0 -10000 0 0
mol:DAG 0 0.001 -10000 0 -10000 0 0
CABIN1/MEF2D/CaM/Ca2+/CAMK IV 0.02 0.074 -10000 0 -0.22 1 1
BCL2/BAX 0.017 0.061 -10000 0 -0.21 1 1
CaM/Ca2+/Calcineurin A alpha-beta B1 0.015 0.01 -10000 0 -10000 0 0
CaM/Ca2+ 0.015 0.01 -10000 0 -10000 0 0
BAX 0.025 0 -10000 0 -10000 0 0
MAPK14 0.025 0.001 -10000 0 -10000 0 0
BAD 0.004 0.081 -10000 0 -0.31 1 1
CABIN1/MEF2D 0.007 0.072 -10000 0 -0.24 1 1
Calcineurin A alpha-beta B1/BCL2 0.001 0.08 -10000 0 -0.31 1 1
FKBP8 0.025 0 -10000 0 -10000 0 0
activation-induced cell death of T cells -0.007 0.071 0.23 1 -10000 0 1
KPNB1 0.012 0.051 -10000 0 -0.19 1 1
KPNA2 0.022 0.008 -10000 0 -10000 0 0
XPO1 0.025 0 -10000 0 -10000 0 0
SFN -0.001 0.07 -10000 0 -0.19 2 2
MAP3K8 0.024 0.006 -10000 0 -10000 0 0
NFAT4/CK1 alpha 0.007 0.045 -10000 0 -0.14 1 1
MEF2D/NFAT1/Cbp/p300 0.03 0.06 -10000 0 -10000 0 0
CABIN1 0 0.069 -10000 0 -0.25 1 1
CALM1 0.022 0.008 -10000 0 -10000 0 0
RAN 0.025 0 -10000 0 -10000 0 0
MAP3K1 0.003 0.081 -10000 0 -0.31 1 1
CAMK4 0.023 0.006 -10000 0 -10000 0 0
mol:Ca2+ 0 0.002 -10000 0 -10000 0 0
MAPK3 0.022 0.008 -10000 0 -10000 0 0
YWHAH 0.012 0.051 -10000 0 -0.19 1 1
Calcineurin A alpha-beta B1/AKAP79/PKA 0.033 0.012 -10000 0 -10000 0 0
YWHAB 0.025 0 -10000 0 -10000 0 0
MAPK8 0.003 0.081 -10000 0 -0.31 1 1
MAPK9 0.003 0.081 -10000 0 -0.31 1 1
YWHAG 0.019 0.011 -10000 0 -10000 0 0
FKBP1A 0.025 0 -10000 0 -10000 0 0
NFAT1-c-4/YWHAQ 0.01 0.076 -10000 0 -0.23 1 1
PRKCH -0.004 0.069 -10000 0 -0.19 2 2
CABIN1/Cbp/p300 0.033 0.013 -10000 0 -10000 0 0
CASP3 0.025 0.001 -10000 0 -10000 0 0
PIM1 0.025 0 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 0.017 0.001 -10000 0 -10000 0 0
apoptosis -0.003 0.063 -10000 0 -0.24 1 1
14-3-3 family/BAD/CaM/Ca2+/Calcineurin A alpha-beta B1 -0.016 0.058 -10000 0 -0.19 1 1
PRKCB 0 0 -10000 0 -10000 0 0
PRKCE 0.023 0.006 -10000 0 -10000 0 0
JNK2/NFAT4 0.008 0.045 -10000 0 -0.16 1 1
BAD/BCL-XL 0.022 0.061 -10000 0 -0.21 1 1
PRKCD 0.025 0 -10000 0 -10000 0 0
NUP214 0.023 0.006 -10000 0 -10000 0 0
PRKCZ 0 0.001 -10000 0 -10000 0 0
PRKCA 0.022 0.008 -10000 0 -10000 0 0
PRKCG 0.001 0.081 -10000 0 -0.31 1 1
PRKCQ 0.01 0.051 -10000 0 -0.19 1 1
FKBP38/BCL2 0.017 0.061 -10000 0 -0.21 1 1
EP300 0.025 0.001 -10000 0 -10000 0 0
PRKCB1 0.001 0.08 -10000 0 -0.31 1 1
CSNK2A1 0.025 0 -10000 0 -10000 0 0
NFATc/JNK1 0.022 0.053 -10000 0 -10000 0 0
CaM/Ca2+/FKBP38 0.03 0.012 -10000 0 -10000 0 0
FKBP12/FK506 0.019 0 -10000 0 -10000 0 0
CSNK1A1 0.009 0.008 -10000 0 -10000 0 0
CaM/Ca2+/CAMK IV 0.03 0.012 -10000 0 -10000 0 0
NFATc/ERK1 0.022 0.053 -10000 0 -10000 0 0
CABIN1/YWHAQ/CaM/Ca2+/CAMK IV 0.012 0.084 -10000 0 -0.22 1 1
NR4A1 0.004 0.055 -10000 0 -10000 0 0
GSK3B 0.025 0.001 -10000 0 -10000 0 0
positive T cell selection 0.008 0.004 -10000 0 -10000 0 0
NFAT1/CK1 alpha -0.004 0.037 -10000 0 -10000 0 0
RCH1/ KPNB1 0.022 0.04 -10000 0 -0.13 1 1
YWHAQ 0.004 0.081 -10000 0 -0.31 1 1
PRKACA 0.025 0.001 -10000 0 -10000 0 0
AKAP5 0.022 0.008 -10000 0 -10000 0 0
MEF2D 0.024 0.006 -10000 0 -10000 0 0
mol:FK506 0 0 -10000 0 -10000 0 0
YWHAZ 0.025 0 -10000 0 -10000 0 0
NFATc/p38 alpha 0.029 0.054 -10000 0 -10000 0 0
CREBBP 0.022 0.008 -10000 0 -10000 0 0
BCL2 0.001 0.08 -10000 0 -0.31 1 1
S1P1 pathway

Figure S83.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S83.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0.011 0.059 -10000 0 -0.22 1 1
PDGFRB 0.024 0.007 -10000 0 -10000 0 0
SPHK1 0.01 0.014 -10000 0 -10000 0 0
mol:S1P 0.023 0.043 -10000 0 -10000 0 0
S1P1/S1P/Gi 0.011 0.069 -10000 0 -10000 0 0
GNAO1 0.025 0.007 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/PLCgamma1 0.035 0.074 -10000 0 -10000 0 0
PLCG1 0.008 0.065 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB 0.024 0.007 -10000 0 -10000 0 0
GNAI2 0.026 0.002 -10000 0 -10000 0 0
GNAI3 0.024 0.006 -10000 0 -10000 0 0
GNAI1 -0.001 0.081 -10000 0 -0.31 1 1
mol:GDP 0 0 -10000 0 -10000 0 0
EDG1 0 0.068 -10000 0 -0.26 1 1
S1P1/S1P 0.02 0.071 -10000 0 -10000 0 0
negative regulation of cAMP metabolic process 0.011 0.067 -10000 0 -10000 0 0
MAPK3 0.003 0.061 -10000 0 -10000 0 0
calcium-dependent phospholipase C activity 0 0.001 -10000 0 -10000 0 0
Rac1/GDP 0.014 0.008 -10000 0 -10000 0 0
RhoA/GDP 0.004 0.055 -10000 0 -0.21 1 1
KDR 0.011 0.067 -10000 0 -0.25 1 1
PLCB2 0.025 0.083 0.21 1 -10000 0 1
RAC1 0.019 0.011 -10000 0 -10000 0 0
RhoA/GTP 0.003 0.064 -10000 0 -10000 0 0
receptor internalization 0.019 0.067 -10000 0 -10000 0 0
PTGS2 0.04 0.077 -10000 0 -10000 0 0
Rac1/GTP 0.001 0.054 -10000 0 -10000 0 0
RHOA 0.004 0.081 -10000 0 -0.31 1 1
VEGFA 0 0.014 -10000 0 -10000 0 0
negative regulation of T cell proliferation 0.011 0.067 -10000 0 -10000 0 0
GO:0007205 0 0 -10000 0 -10000 0 0
GNAZ 0.026 0.003 -10000 0 -10000 0 0
MAPK1 0.007 0.062 -10000 0 -10000 0 0
S1P1/S1P/PDGFB-D/PDGFRB 0.033 0.08 -10000 0 -0.24 1 1
ABCC1 0.023 0.009 -10000 0 -10000 0 0
Signaling events mediated by HDAC Class I

Figure S84.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S84.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NF kappa B/RelA 0.054 0.036 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC1 -0.011 0.003 -9999 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.032 0.038 -9999 0 -10000 0 0
SUMO1 0.025 0 -9999 0 -10000 0 0
ZFPM1 0.01 0.051 -9999 0 -0.19 1 1
NPC/RanGAP1/SUMO1/Ubc9 0.011 0.004 -9999 0 -10000 0 0
FKBP3 0.022 0.008 -9999 0 -10000 0 0
Histones 0.052 0.028 -9999 0 -10000 0 0
YY1/LSF 0.023 0.036 -9999 0 -10000 0 0
SMG5 0 0 -9999 0 -10000 0 0
RAN 0.025 0 -9999 0 -10000 0 0
I kappa B alpha/HDAC3 0.013 0.038 -9999 0 -10000 0 0
I kappa B alpha/HDAC1 0.018 0.058 -9999 0 -0.2 1 1
SAP18 0.025 0 -9999 0 -10000 0 0
RELA 0.016 0.013 -9999 0 -10000 0 0
HDAC1/Smad7 0.032 0.025 -9999 0 -10000 0 0
RANGAP1 0.025 0 -9999 0 -10000 0 0
HDAC3/TR2 0.028 0.019 -9999 0 -10000 0 0
NuRD/MBD3 Complex -0.013 0.084 -9999 0 -0.26 1 1
NF kappa B1 p50/RelA 0.032 0.022 -9999 0 -10000 0 0
EntrezGene:23225 0 0 -9999 0 -10000 0 0
GATA2 0.025 0 -9999 0 -10000 0 0
GATA1 -0.001 0.07 -9999 0 -0.19 2 2
Mad/Max 0.033 0.012 -9999 0 -10000 0 0
NuRD/MBD3 Complex/GATA1/Fog1 -0.014 0.094 -9999 0 -0.27 1 1
RBBP7 0.025 0 -9999 0 -10000 0 0
NPC 0.015 0 -9999 0 -10000 0 0
RBBP4 0.003 0.081 -9999 0 -0.31 1 1
MAX 0.022 0.008 -9999 0 -10000 0 0
EntrezGene:9972 0 0 -9999 0 -10000 0 0
FBXW11 0.023 0.006 -9999 0 -10000 0 0
NFKBIA 0.004 0.059 -9999 0 -0.22 1 1
KAT2B 0 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
SIN3/HDAC complex 0.012 0.041 -9999 0 -10000 0 0
SIN3 complex 0.061 0.016 -9999 0 -10000 0 0
SMURF1 0.017 0.012 -9999 0 -10000 0 0
CHD3 0.01 0.051 -9999 0 -0.19 1 1
SAP30 0.023 0.006 -9999 0 -10000 0 0
EntrezGene:23636 0 0 -9999 0 -10000 0 0
NCOR1 0.023 0.006 -9999 0 -10000 0 0
YY1/HDAC3 0.02 0.038 -9999 0 -10000 0 0
YY1/HDAC2 0.023 0.036 -9999 0 -10000 0 0
YY1/HDAC1 0.023 0.036 -9999 0 -10000 0 0
NuRD/MBD2 Complex (MeCP1) -0.019 0.084 -9999 0 -0.26 1 1
PPARG 0.013 0.019 -9999 0 -10000 0 0
HDAC8/hEST1B 0.034 0 -9999 0 -10000 0 0
UBE2I 0.022 0.008 -9999 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.023 0.006 -9999 0 -10000 0 0
TNFRSF1A 0.025 0 -9999 0 -10000 0 0
HDAC3/SMRT (N-CoR2) 0.028 0.019 -9999 0 -10000 0 0
MBD3L2 0.004 0.081 -9999 0 -0.31 1 1
ubiquitin-dependent protein catabolic process 0.032 0.024 -9999 0 -10000 0 0
CREBBP 0.022 0.008 -9999 0 -10000 0 0
NuRD/MBD3/MBD3L2 Complex -0.023 0.098 -9999 0 -0.29 1 1
HDAC1 0.023 0.006 -9999 0 -10000 0 0
HDAC3 0.015 0.015 -9999 0 -10000 0 0
HDAC2 0.025 0 -9999 0 -10000 0 0
YY1 0.01 0.005 -9999 0 -10000 0 0
HDAC8 0.025 0 -9999 0 -10000 0 0
SMAD7 0.023 0.006 -9999 0 -10000 0 0
NCOR2 0.025 0 -9999 0 -10000 0 0
MXD1 0.025 0 -9999 0 -10000 0 0
STAT3 -0.001 0.061 -9999 0 -0.23 1 1
NFKB1 0.004 0.081 -9999 0 -0.31 1 1
EntrezGene:8021 0 0 -9999 0 -10000 0 0
RANBP2 0.025 0 -9999 0 -10000 0 0
YY1/LSF/HDAC1 0.036 0.037 -9999 0 -10000 0 0
YY1/SAP30/HDAC1 0.036 0.037 -9999 0 -10000 0 0
EP300 0.025 0 -9999 0 -10000 0 0
STAT3 (dimer non-phopshorylated) -0.001 0.061 -9999 0 -0.23 1 1
proteasomal ubiquitin-dependent protein catabolic process 0.004 0.058 -9999 0 -0.22 1 1
histone deacetylation -0.019 0.084 -9999 0 -0.26 1 1
STAT3 (dimer non-phopshorylated)/HDAC3 0.008 0.047 -9999 0 -10000 0 0
nuclear export -0.034 0 -9999 0 -10000 0 0
PRKACA 0.025 0 -9999 0 -10000 0 0
GATAD2B 0.023 0.006 -9999 0 -10000 0 0
GATAD2A 0.025 0 -9999 0 -10000 0 0
GATA2/HDAC3 0.028 0.019 -9999 0 -10000 0 0
GATA1/HDAC1 0.015 0.054 -9999 0 -0.13 2 2
GATA1/HDAC3 0.013 0.04 -9999 0 -10000 0 0
CHD4 0.025 0 -9999 0 -10000 0 0
TNF-alpha/TNFR1A 0.027 0.039 -9999 0 -0.13 1 1
SIN3/HDAC complex/Mad/Max 0.01 0.041 -9999 0 -10000 0 0
NuRD Complex -0.019 0.095 -9999 0 -0.29 1 1
positive regulation of chromatin silencing 0.05 0.027 -9999 0 -10000 0 0
SIN3B 0.025 0 -9999 0 -10000 0 0
MTA2 -0.038 0.13 -9999 0 -0.31 3 3
SIN3A 0.025 0 -9999 0 -10000 0 0
XPO1 0.025 0 -9999 0 -10000 0 0
SUMO1/HDAC1 0.041 0.019 -9999 0 -10000 0 0
HDAC complex 0.046 0.057 -9999 0 -0.16 1 1
GATA1/Fog1 0.004 0.063 -9999 0 -0.13 3 3
FKBP25/HDAC1/HDAC2 0.045 0.017 -9999 0 -10000 0 0
TNF 0.012 0.051 -9999 0 -0.19 1 1
negative regulation of cell growth 0.01 0.041 -9999 0 -10000 0 0
NuRD/MBD2/PRMT5 Complex -0.019 0.084 -9999 0 -0.26 1 1
Ran/GTP/Exportin 1 0.047 0.019 -9999 0 -10000 0 0
NF kappa B/RelA/I kappa B alpha 0.025 0.016 -9999 0 -10000 0 0
SIN3/HDAC complex/NCoR1 -0.009 0.1 -9999 0 -0.36 1 1
TFCP2 0.025 0 -9999 0 -10000 0 0
NR2C1 0.025 0 -9999 0 -10000 0 0
MBD3 0.023 0.006 -9999 0 -10000 0 0
MBD2 0.023 0.006 -9999 0 -10000 0 0
TCGA08_p53

Figure S85.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S85.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2A -0.005 0.002 -10000 0 -10000 0 0
TP53 -0.01 0.062 -10000 0 -0.25 1 1
Senescence -0.01 0.062 -10000 0 -0.25 1 1
Apoptosis -0.01 0.062 -10000 0 -0.25 1 1
Activated_Oncogenes 0 0 -10000 0 -10000 0 0
MDM2 0.03 0.098 0.29 2 -10000 0 2
MDM4 0.023 0.006 -10000 0 -10000 0 0
FoxO family signaling

Figure S86.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S86.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G6PC 0.038 0.098 -10000 0 -10000 0 0
PLK1 0.021 0.11 -10000 0 -10000 0 0
CDKN1B 0.01 0.12 -10000 0 -0.31 1 1
FOXO3 0.004 0.098 -10000 0 -10000 0 0
KAT2B 0.003 0.01 -10000 0 -10000 0 0
FOXO1/SIRT1 0.025 0.041 -10000 0 -10000 0 0
CAT -0.001 0.092 -10000 0 -10000 0 0
CTNNB1 -0.018 0.11 -10000 0 -0.31 2 2
AKT1 0.02 0.025 -10000 0 -10000 0 0
FOXO1 0.02 0.048 -10000 0 -10000 0 0
MAPK10 0.037 0.08 0.19 3 -10000 0 3
mol:GTP 0 0.003 -10000 0 -10000 0 0
FOXO4 0.007 0.11 0.19 2 -10000 0 2
response to oxidative stress 0.004 0.013 -10000 0 -10000 0 0
FOXO3A/SIRT1 0.025 0.072 -10000 0 -10000 0 0
XPO1 0.025 0.001 -10000 0 -10000 0 0
EP300 0.024 0.012 -10000 0 -10000 0 0
BCL2L11 -0.044 0.28 -10000 0 -1.1 1 1
FOXO1/SKP2 0.029 0.046 -10000 0 -10000 0 0
mol:GDP 0.004 0.013 -10000 0 -10000 0 0
RAN 0.025 0.002 -10000 0 -10000 0 0
GADD45A -0.031 0.22 -10000 0 -0.81 1 1
YWHAQ 0.004 0.081 -10000 0 -0.31 1 1
FOXO1/14-3-3 family 0.05 0.031 -10000 0 -10000 0 0
MST1 0.013 0.052 -10000 0 -0.18 1 1
CSNK1D 0.022 0.008 -10000 0 -10000 0 0
CSNK1E 0.025 0 -10000 0 -10000 0 0
FOXO4/14-3-3 family -0.004 0.059 -10000 0 -10000 0 0
YWHAB 0.025 0 -10000 0 -10000 0 0
MAPK8 0.04 0.073 0.19 3 -10000 0 3
MAPK9 0.04 0.072 0.19 3 -10000 0 3
YWHAG 0.019 0.011 -10000 0 -10000 0 0
YWHAE 0.022 0.008 -10000 0 -10000 0 0
YWHAZ 0.025 0 -10000 0 -10000 0 0
SIRT1 0.023 0.017 -10000 0 -10000 0 0
SOD2 -0.017 0.22 -10000 0 -0.81 1 1
RBL2 0.018 0.088 -10000 0 -10000 0 0
RAL/GDP 0.023 0.027 -10000 0 -10000 0 0
CHUK 0.003 0.081 -10000 0 -0.3 1 1
Ran/GTP 0.016 0.011 -10000 0 -10000 0 0
CSNK1G2 0.01 0.051 -10000 0 -0.19 1 1
RAL/GTP 0.024 0.028 -10000 0 -10000 0 0
CSNK1G1 0.025 0 -10000 0 -10000 0 0
FASLG -0.01 0.061 -10000 0 -10000 0 0
SKP2 0.025 0 -10000 0 -10000 0 0
USP7 0.022 0.008 -10000 0 -10000 0 0
IKBKB 0.026 0.018 -10000 0 -10000 0 0
CCNB1 -0.002 0.092 -10000 0 -10000 0 0
FOXO1-3a-4/beta catenin 0.016 0.14 -10000 0 -0.4 1 1
proteasomal ubiquitin-dependent protein catabolic process 0.029 0.046 -10000 0 -10000 0 0
CSNK1A1 0.023 0.006 -10000 0 -10000 0 0
SGK1 0.003 0.01 -10000 0 -10000 0 0
CSNK1G3 0.023 0.006 -10000 0 -10000 0 0
Ran/GTP/Exportin 1 0.032 0.014 -10000 0 -10000 0 0
ZFAND5 0.013 0.098 0.18 3 -10000 0 3
SFN -0.001 0.07 -10000 0 -0.19 2 2
CDK2 0.024 0.014 -10000 0 -10000 0 0
FOXO3A/14-3-3 -0.006 0.067 -10000 0 -10000 0 0
CREBBP 0.02 0.016 -10000 0 -10000 0 0
FBXO32 -0.002 0.092 -10000 0 -10000 0 0
BCL6 0.02 0.089 -10000 0 -10000 0 0
RALB 0.004 0.083 -10000 0 -0.32 1 1
RALA 0.019 0.011 -10000 0 -10000 0 0
YWHAH 0.012 0.051 -10000 0 -0.19 1 1
FAS signaling pathway (CD95)

Figure S87.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S87.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPTAN1 -0.005 0.004 -10000 0 -10000 0 0
RFC1 0.004 0.039 0.15 1 -10000 0 1
PRKDC 0.004 0.039 0.15 1 -10000 0 1
RIPK1 0.026 0.003 -10000 0 -10000 0 0
CASP7 0.007 0.022 -10000 0 -10000 0 0
FASLG/FAS/FADD/FAF1 -0.012 0.063 -10000 0 -0.18 1 1
MAP2K4 -0.023 0.078 -10000 0 -0.25 1 1
mol:ceramide -0.016 0.064 -10000 0 -10000 0 0
GSN -0.005 0.004 -10000 0 -10000 0 0
FASLG/FAS/FADD/FAF1/Caspase 8 -0.011 0.06 -10000 0 -10000 0 0
FAS -0.014 0.092 -10000 0 -0.25 2 2
BID -0.036 0.046 -10000 0 -0.19 1 1
MAP3K1 -0.021 0.079 -10000 0 -0.25 1 1
MAP3K7 0.022 0.011 -10000 0 -10000 0 0
RB1 0.004 0.039 0.15 1 -10000 0 1
CFLAR 0.026 0.003 -10000 0 -10000 0 0
HGF/MET 0.017 0.057 -10000 0 -0.18 1 1
ARHGDIB 0.004 0.039 0.15 1 -10000 0 1
FADD 0.022 0.013 -10000 0 -10000 0 0
actin filament polymerization 0.016 0.04 0.17 1 -10000 0 1
NFKB1 0.006 0.051 -10000 0 -10000 0 0
MAPK8 -0.042 0.11 -10000 0 -0.42 1 1
DFFA 0.004 0.039 0.15 1 -10000 0 1
DNA fragmentation during apoptosis -0.007 0.057 0.15 1 -0.17 1 2
FAS/FADD/MET 0.023 0.029 -10000 0 -10000 0 0
CFLAR/RIP1 0.038 0.004 -10000 0 -10000 0 0
FAIM3 0.024 0.006 -10000 0 -10000 0 0
FAF1 0.02 0.016 -10000 0 -10000 0 0
PARP1 0.004 0.039 0.15 1 -10000 0 1
DFFB 0.004 0.039 0.15 1 -10000 0 1
CHUK -0.009 0.054 -10000 0 -10000 0 0
FASLG -0.033 0.089 -10000 0 -0.18 4 4
FAS/FADD 0.005 0.07 -10000 0 -0.17 2 2
HGF 0.019 0.011 -10000 0 -10000 0 0
LMNA -0.009 0.052 -10000 0 -10000 0 0
CASP6 0.004 0.039 0.15 1 -10000 0 1
CASP10 0.022 0.013 -10000 0 -10000 0 0
CASP3 0.009 0.046 0.19 1 -10000 0 1
PTPN13 0.004 0.081 -10000 0 -0.31 1 1
CASP8 -0.02 0.005 -10000 0 -10000 0 0
IL6 -0.082 0.27 -10000 0 -0.73 2 2
MET 0.016 0.012 -10000 0 -10000 0 0
ICAD/CAD 0.001 0.035 -10000 0 -10000 0 0
FASLG/FAS/FADD/FAF1/Caspase 10 -0.016 0.064 -10000 0 -10000 0 0
activation of caspase activity by cytochrome c -0.036 0.045 -10000 0 -0.19 1 1
PAK2 0.018 0.064 0.18 2 -10000 0 2
BCL2 0.001 0.08 -10000 0 -0.31 1 1
Retinoic acid receptors-mediated signaling

Figure S88.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S88.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.023 0.006 -10000 0 -10000 0 0
HDAC3 0.023 0.006 -10000 0 -10000 0 0
VDR -0.001 0.07 -10000 0 -0.19 2 2
Cbp/p300/PCAF 0.03 0.011 -10000 0 -10000 0 0
EP300 0.025 0 -10000 0 -10000 0 0
RARs/AIB1/Cbp/p300/PCAF/9cRA 0.018 0.012 -10000 0 -10000 0 0
KAT2B 0 0 -10000 0 -10000 0 0
MAPK14 0.025 0 -10000 0 -10000 0 0
AKT1 0.011 0.051 0.16 1 -10000 0 1
RAR alpha/9cRA/Cyclin H 0.024 0.057 -10000 0 -10000 0 0
mol:9cRA 0 0 -10000 0 -10000 0 0
RARs/Src-1/Cbp/p300/PCAF/9cRA 0.018 0.012 -10000 0 -10000 0 0
CDC2 0.011 0.051 -10000 0 -0.19 1 1
response to UV 0.001 0 -10000 0 -10000 0 0
RAR alpha/Jnk1 0.001 0.077 -10000 0 -0.29 1 1
NCOR2 0.025 0 -10000 0 -10000 0 0
VDR/VDR/Vit D3 0.001 0.046 -10000 0 -0.12 2 2
RXRs/RARs/NRIP1/9cRA 0.007 0.071 -10000 0 -10000 0 0
NCOA2 0.025 0 -10000 0 -10000 0 0
NCOA3 0.025 0 -10000 0 -10000 0 0
NCOA1 0.025 0 -10000 0 -10000 0 0
VDR/VDR/DNA -0.001 0.07 -10000 0 -0.19 2 2
RARG 0.026 0 -10000 0 -10000 0 0
RAR gamma1/9cRA 0.034 0 -10000 0 -10000 0 0
MAPK3 0.022 0.008 -10000 0 -10000 0 0
MAPK1 0.025 0 -10000 0 -10000 0 0
MAPK8 0.003 0.081 -10000 0 -0.31 1 1
mol:Vit D3 0 0 -10000 0 -10000 0 0
RXRs/VDR/DNA/Vit D3 0.003 0.082 -10000 0 -0.28 1 1
RARA 0.003 0.048 -10000 0 -0.18 1 1
negative regulation of phosphoinositide 3-kinase cascade 0 0 -10000 0 -10000 0 0
RARs/TIF2/Cbp/p300/PCAF/9cRA 0.018 0.012 -10000 0 -10000 0 0
PRKCA 0.024 0.009 -10000 0 -10000 0 0
RXRs/RARs/NRIP1/9cRA/HDAC1 0.008 0.073 -10000 0 -10000 0 0
RXRG 0.014 0.019 -10000 0 -10000 0 0
RXRA 0.014 0.007 -10000 0 -10000 0 0
RXRB 0.018 0.007 -10000 0 -10000 0 0
VDR/Vit D3/DNA 0.001 0.046 -10000 0 -0.12 2 2
RBP1 -0.009 0.093 -10000 0 -0.25 2 2
CRBP1/9-cic-RA -0.004 0.063 -10000 0 -0.16 2 2
RARB 0.025 0.006 -10000 0 -10000 0 0
PRKCG 0.004 0.081 -10000 0 -0.31 1 1
MNAT1 0.022 0.008 -10000 0 -10000 0 0
RAR alpha/RXRs 0.008 0.091 -10000 0 -0.31 1 1
RXRs/RARs/SMRT(N-CoR2)/9cRA 0.013 0.061 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.012 0.027 -10000 0 -10000 0 0
RXRs/RARs/NRIP1/9cRA/HDAC3 0.008 0.073 -10000 0 -10000 0 0
positive regulation of DNA binding 0.018 0.052 -10000 0 -10000 0 0
NRIP1 0.006 0.065 -10000 0 -10000 0 0
RXRs/RARs 0.012 0.071 -10000 0 -10000 0 0
RXRs/RXRs/DNA/9cRA 0.004 0.075 -10000 0 -0.28 1 1
PRKACA 0.025 0 -10000 0 -10000 0 0
CDK7 0.023 0.006 -10000 0 -10000 0 0
TFIIH 0.045 0.017 -10000 0 -10000 0 0
RAR alpha/9cRA 0.032 0.055 -10000 0 -10000 0 0
CCNH 0.023 0.006 -10000 0 -10000 0 0
CREBBP 0.022 0.008 -10000 0 -10000 0 0
RAR gamma2/9cRA 0.044 0.018 -10000 0 -10000 0 0
Paxillin-dependent events mediated by a4b1

Figure S89.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S89.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.025 0 -10000 0 -10000 0 0
Rac1/GDP 0.022 0.014 -10000 0 -10000 0 0
DOCK1 0.023 0.006 -10000 0 -10000 0 0
ITGA4 -0.009 0.093 -10000 0 -0.25 2 2
RAC1 0.019 0.011 -10000 0 -10000 0 0
alpha4/beta7 Integrin 0.001 0.077 -10000 0 -0.16 3 3
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.022 0.008 -10000 0 -10000 0 0
alpha4/beta1 Integrin 0.024 0.066 -10000 0 -0.18 1 1
alpha4/beta7 Integrin/Paxillin 0.011 0.064 -10000 0 -0.16 1 1
lamellipodium assembly 0.011 0.12 -10000 0 -0.41 1 1
PIK3CA 0.025 0 -10000 0 -10000 0 0
PI3K 0.035 0.009 -10000 0 -10000 0 0
ARF6 0.022 0.008 -10000 0 -10000 0 0
TLN1 0.022 0.008 -10000 0 -10000 0 0
PXN -0.011 0 -10000 0 -10000 0 0
PIK3R1 0.023 0.006 -10000 0 -10000 0 0
ARF6/GTP 0.025 0.058 -10000 0 -10000 0 0
cell adhesion 0.024 0.06 -10000 0 -0.16 1 1
CRKL/CBL 0.037 0 -10000 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin 0.017 0.058 -10000 0 -0.16 1 1
ITGB1 0.023 0.006 -10000 0 -10000 0 0
ITGB7 0.012 0.051 -10000 0 -0.19 1 1
ARF6/GDP 0.026 0.011 -10000 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin/VCAM1 -0.01 0.086 -10000 0 -0.16 3 3
p130Cas/Crk/Dock1 0.041 0.02 -10000 0 -10000 0 0
VCAM1 -0.031 0.12 -10000 0 -0.27 3 3
alpha4/beta1 Integrin/Paxillin/Talin 0.026 0.061 -10000 0 -0.16 1 1
alpha4/beta1 Integrin/Paxillin/GIT1 0.029 0.061 -10000 0 -0.16 1 1
BCAR1 0.023 0.006 -10000 0 -10000 0 0
mol:GDP -0.028 0.06 0.16 1 -10000 0 1
CBL 0.025 0 -10000 0 -10000 0 0
PRKACA 0.025 0 -10000 0 -10000 0 0
GIT1 0.025 0 -10000 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin/Talin/Actin Cytoskeleton 0.026 0.061 -10000 0 -0.16 1 1
Rac1/GTP 0.009 0.13 -10000 0 -0.45 1 1
Atypical NF-kappaB pathway

Figure S90.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S90.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL3/RelA 0.037 0 -9999 0 -10000 0 0
FBXW11 0.023 0.006 -9999 0 -10000 0 0
NF kappa B1 p50/c-Rel 0.005 0.058 -9999 0 -0.18 1 1
NF kappa B1 p50/RelA/I kappa B alpha -0.028 0.077 -9999 0 -0.2 1 1
NFKBIA -0.017 0.053 -9999 0 -0.15 2 2
MAPK14 0.025 0 -9999 0 -10000 0 0
NF kappa B1 p105/p50 0.025 0.006