Uterine Corpus Endometrioid Carcinoma: Correlation between copy number variation genes and selected clinical features

Maintained by TCGA GDAC Team (Broad Institute/Dana-Farber Cancer Institute/Harvard Medical School)

Overview

Introduction

This pipeline computes the correlation between significant copy number variation (cnv) genes and selected clinical features.

Summary

Testing the association between copy number variation of 88 peak regions and 5 clinical features across 410 patients, 115 significant findings detected with Q value < 0.25.

Amp Peak 1(1p34.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 3(1q21.3) cnvs correlated to 'AGE'.
Amp Peak 4(1q22) cnvs correlated to 'AGE'.
Amp Peak 5(2p23.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 6(2q13) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 7(3p25.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 8(3q26.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 9(3q26.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 10(4p16.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 11(5p15.33) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 12(6p24.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 16(8p11.21) cnvs correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.
Amp Peak 17(8q24.21) cnvs correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.
Amp Peak 18(8q24.21) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 19(9p24.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 20(9q34.3) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 22(11p11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 23(11q13.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 24(11q22.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 27(12q13.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 28(14q24.3) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 29(14q32.33) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 31(16p11.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 32(17p11.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 33(17q11.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 34(17q12) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 35(17q21.32) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 36(18q11.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 37(19p13.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 38(19p13.13) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 39(19q12) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.
Amp Peak 40(20p13) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 41(20q11.21) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 42(20q13.12) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 43(20q13.33) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 1(1p36.31) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 2(1p36.11) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 3(2q22.1) cnvs correlated to 'Time to Death'.
Del Peak 5(3p14.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 6(4p16.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 7(4q22.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 8(4q34.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 9(5q11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 11(7p22.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 12(7q11.22) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 13(7q36.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 14(8p23.3) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 15(8p11.22) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 16(9p23) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 17(9q34.11) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 20(11p15.5) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 21(11q14.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 22(11q24.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 24(12q24.33) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 25(13q11) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 27(14q13.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 28(15q15.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 29(15q23) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 30(16p13.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 31(16q22.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 32(16q23.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 33(17p13.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 34(17p11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 35(17p11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 36(17q11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 37(17q21.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 38(18q23) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 39(19p13.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 40(19q13.43) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 45(22q13.32) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

Results

Overview of the results

Table 1. Get Full Table Overview of the association between significant copy number variation of 88 regions and 5 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 115 significant findings detected.


		Clinical Features	Time to Death	AGE	HISTOLOGICAL TYPE	RADIATIONS RADIATION REGIMENINDICATION	NEOADJUVANT THERAPY
	nCNV (%)	nWild-Type	logrank test	t-test	Chi-square test	Fisher's exact test	Fisher's exact test
Amp Peak 39(19q12)	49 (12%)	361	0.0233 (1.00)	8.84e-07 (0.000334)	6.08e-24 (2.67e-21)	0.514 (1.00)	3.68e-05 (0.013)
Amp Peak 7(3p25 1)	48 (12%)	362	0.321 (1.00)	0.000573 (0.189)	3.33e-07 (0.000127)	0.324 (1.00)	0.377 (1.00)
Amp Peak 8(3q26 2)	100 (24%)	310	0.212 (1.00)	1.47e-07 (5.67e-05)	2.64e-18 (1.14e-15)	0.109 (1.00)	0.0252 (1.00)
Amp Peak 9(3q26 2)	95 (23%)	315	0.05 (1.00)	3.75e-05 (0.0132)	7.9e-19 (3.41e-16)	0.132 (1.00)	0.0798 (1.00)
Amp Peak 10(4p16 3)	27 (7%)	383	0.895 (1.00)	6.99e-06 (0.00254)	2.53e-13 (1.07e-10)	0.531 (1.00)	0.0364 (1.00)
Amp Peak 12(6p24 2)	58 (14%)	352	0.949 (1.00)	0.000327 (0.111)	1.53e-10 (6.26e-08)	0.761 (1.00)	0.328 (1.00)
Amp Peak 16(8p11 21)	98 (24%)	312	4.98e-06 (0.00182)	0.941 (1.00)	0.000563 (0.186)	0.321 (1.00)	0.184 (1.00)
Amp Peak 17(8q24 21)	125 (30%)	285	0.000637 (0.208)	0.146 (1.00)	1.2e-08 (4.75e-06)	0.421 (1.00)	0.00135 (0.427)
Amp Peak 22(11p11 2)	23 (6%)	387	0.384 (1.00)	0.000598 (0.197)	3.37e-08 (1.31e-05)	1 (1.00)	0.139 (1.00)
Amp Peak 34(17q12)	46 (11%)	364	0.0319 (1.00)	4.53e-05 (0.0159)	1.44e-15 (6.11e-13)	0.502 (1.00)	0.00183 (0.57)
Amp Peak 35(17q21 32)	36 (9%)	374	0.013 (1.00)	2.52e-05 (0.00902)	3.74e-06 (0.00138)	0.578 (1.00)	0.158 (1.00)
Amp Peak 37(19p13 2)	49 (12%)	361	0.799 (1.00)	2.3e-10 (9.32e-08)	8.1e-16 (3.45e-13)	0.073 (1.00)	0.727 (1.00)
Amp Peak 38(19p13 13)	53 (13%)	357	0.594 (1.00)	4.88e-11 (2.01e-08)	3.46e-19 (1.5e-16)	0.155 (1.00)	0.239 (1.00)
Amp Peak 41(20q11 21)	65 (16%)	345	0.904 (1.00)	0.000187 (0.0639)	7.37e-20 (3.2e-17)	0.471 (1.00)	0.0287 (1.00)
Amp Peak 42(20q13 12)	67 (16%)	343	0.101 (1.00)	7.44e-05 (0.0259)	3.15e-18 (1.35e-15)	0.152 (1.00)	0.0205 (1.00)
Amp Peak 43(20q13 33)	68 (17%)	342	0.452 (1.00)	0.000195 (0.0665)	1.95e-11 (8.06e-09)	0.118 (1.00)	0.0221 (1.00)
Del Peak 2(1p36 11)	46 (11%)	364	0.15 (1.00)	0.000629 (0.206)	5.65e-10 (2.27e-07)	0.868 (1.00)	0.28 (1.00)
Del Peak 5(3p14 2)	40 (10%)	370	0.425 (1.00)	2.97e-05 (0.0106)	4.56e-10 (1.84e-07)	0.86 (1.00)	0.179 (1.00)
Del Peak 6(4p16 3)	45 (11%)	365	0.125 (1.00)	0.000132 (0.0454)	3.8e-11 (1.56e-08)	0.499 (1.00)	0.366 (1.00)
Del Peak 7(4q22 1)	46 (11%)	364	0.029 (1.00)	0.000763 (0.249)	1.18e-12 (4.96e-10)	0.132 (1.00)	0.28 (1.00)
Del Peak 8(4q34 3)	63 (15%)	347	0.269 (1.00)	6.48e-05 (0.0227)	3.04e-17 (1.3e-14)	0.561 (1.00)	0.00703 (1.00)
Del Peak 9(5q11 2)	53 (13%)	357	0.458 (1.00)	7.98e-05 (0.0277)	1.13e-21 (4.91e-19)	1 (1.00)	0.0169 (1.00)
Del Peak 11(7p22 3)	44 (11%)	366	0.0426 (1.00)	0.000118 (0.0408)	2.65e-10 (1.07e-07)	1 (1.00)	0.0427 (1.00)
Del Peak 13(7q36 1)	40 (10%)	370	0.203 (1.00)	1.15e-06 (0.00043)	6.81e-20 (2.96e-17)	0.476 (1.00)	0.00173 (0.546)
Del Peak 16(9p23)	36 (9%)	374	0.439 (1.00)	0.000322 (0.109)	2.95e-08 (1.15e-05)	0.709 (1.00)	0.0692 (1.00)
Del Peak 17(9q34 11)	75 (18%)	335	0.464 (1.00)	2.51e-08 (9.85e-06)	1.51e-10 (6.2e-08)	0.681 (1.00)	0.027 (1.00)
Del Peak 20(11p15 5)	54 (13%)	356	0.0134 (1.00)	2.26e-06 (0.000836)	2.63e-12 (1.1e-09)	0.35 (1.00)	0.00381 (1.00)
Del Peak 21(11q14 1)	38 (9%)	372	0.00766 (1.00)	0.00034 (0.115)	1.63e-08 (6.44e-06)	0.472 (1.00)	0.116 (1.00)
Del Peak 22(11q24 2)	48 (12%)	362	0.00236 (0.728)	7.03e-05 (0.0245)	7.84e-09 (3.13e-06)	0.512 (1.00)	0.0513 (1.00)
Del Peak 24(12q24 33)	26 (6%)	384	0.496 (1.00)	0.000398 (0.133)	3.81e-06 (0.0014)	0.389 (1.00)	0.253 (1.00)
Del Peak 25(13q11)	43 (10%)	367	0.305 (1.00)	0.000346 (0.116)	2e-06 (0.000744)	0.391 (1.00)	0.46 (1.00)
Del Peak 27(14q13 1)	34 (8%)	376	0.00966 (1.00)	3.65e-05 (0.0129)	6.3e-07 (0.000239)	1 (1.00)	0.038 (1.00)
Del Peak 28(15q15 1)	73 (18%)	337	0.198 (1.00)	1.26e-06 (0.000472)	1.73e-10 (7.05e-08)	0.167 (1.00)	0.0741 (1.00)
Del Peak 29(15q23)	57 (14%)	353	0.108 (1.00)	5.07e-06 (0.00185)	1.91e-11 (7.91e-09)	0.544 (1.00)	0.0732 (1.00)
Del Peak 30(16p13 3)	43 (10%)	367	0.00398 (1.00)	9.23e-07 (0.000347)	4.01e-07 (0.000153)	0.391 (1.00)	0.854 (1.00)
Del Peak 31(16q22 3)	95 (23%)	315	0.169 (1.00)	8.7e-08 (3.37e-05)	3.46e-16 (1.48e-13)	0.616 (1.00)	0.0431 (1.00)
Del Peak 32(16q23 1)	100 (24%)	310	0.133 (1.00)	1.27e-08 (5.02e-06)	3.62e-19 (1.56e-16)	0.538 (1.00)	0.00343 (1.00)
Del Peak 33(17p13 3)	61 (15%)	349	0.201 (1.00)	2.14e-05 (0.00768)	1.17e-11 (4.87e-09)	0.552 (1.00)	0.00382 (1.00)
Del Peak 34(17p11 2)	71 (17%)	339	0.135 (1.00)	4.2e-07 (0.000159)	2.8e-22 (1.23e-19)	0.33 (1.00)	0.00415 (1.00)
Del Peak 35(17p11 2)	64 (16%)	346	0.43 (1.00)	2.37e-06 (0.000873)	3.33e-14 (1.41e-11)	1 (1.00)	0.0851 (1.00)
Del Peak 36(17q11 2)	60 (15%)	350	0.938 (1.00)	1.28e-05 (0.0046)	3.19e-09 (1.28e-06)	0.372 (1.00)	0.148 (1.00)
Del Peak 37(17q21 2)	61 (15%)	349	0.58 (1.00)	5.37e-06 (0.00196)	2.87e-10 (1.16e-07)	0.234 (1.00)	0.0544 (1.00)
Del Peak 39(19p13 3)	95 (23%)	315	0.0346 (1.00)	3.14e-13 (1.32e-10)	2.86e-42 (1.26e-39)	0.452 (1.00)	0.00193 (0.6)
Del Peak 45(22q13 32)	79 (19%)	331	0.0572 (1.00)	1.84e-07 (7.08e-05)	2.43e-13 (1.03e-10)	0.422 (1.00)	0.0605 (1.00)
Amp Peak 1(1p34 2)	26 (6%)	384	0.843 (1.00)	0.00103 (0.331)	1.09e-08 (4.33e-06)	1 (1.00)	0.159 (1.00)
Amp Peak 3(1q21 3)	160 (39%)	250	0.308 (1.00)	0.000375 (0.126)	0.044 (1.00)	1 (1.00)	0.729 (1.00)
Amp Peak 4(1q22)	170 (41%)	240	0.0594 (1.00)	3.1e-05 (0.011)	0.0159 (1.00)	1 (1.00)	0.647 (1.00)
Amp Peak 5(2p23 2)	72 (18%)	338	0.0574 (1.00)	0.00345 (1.00)	2.63e-07 (0.000101)	0.0526 (1.00)	0.456 (1.00)
Amp Peak 6(2q13)	66 (16%)	344	0.072 (1.00)	0.00124 (0.393)	4.69e-08 (1.82e-05)	0.775 (1.00)	0.0636 (1.00)
Amp Peak 11(5p15 33)	48 (12%)	362	0.0179 (1.00)	0.00979 (1.00)	6.55e-12 (2.72e-09)	1 (1.00)	0.216 (1.00)
Amp Peak 18(8q24 21)	132 (32%)	278	0.00681 (1.00)	0.0488 (1.00)	1.22e-09 (4.91e-07)	0.175 (1.00)	0.00732 (1.00)
Amp Peak 19(9p24 2)	33 (8%)	377	0.534 (1.00)	0.0808 (1.00)	7.7e-06 (0.00279)	0.242 (1.00)	0.145 (1.00)
Amp Peak 20(9q34 3)	20 (5%)	390	0.00311 (0.939)	0.00111 (0.354)	9.12e-07 (0.000344)	1 (1.00)	0.0607 (1.00)
Amp Peak 23(11q13 2)	33 (8%)	377	0.219 (1.00)	0.208 (1.00)	0.000101 (0.0348)	0.848 (1.00)	0.0108 (1.00)
Amp Peak 24(11q22 2)	24 (6%)	386	0.145 (1.00)	0.001 (0.323)	9.74e-05 (0.0337)	0.174 (1.00)	0.0272 (1.00)
Amp Peak 27(12q13 2)	50 (12%)	360	0.512 (1.00)	0.157 (1.00)	9.11e-06 (0.00329)	0.419 (1.00)	0.729 (1.00)
Amp Peak 28(14q24 3)	30 (7%)	380	0.772 (1.00)	0.0134 (1.00)	3.57e-07 (0.000137)	0.16 (1.00)	0.0786 (1.00)
Amp Peak 29(14q32 33)	31 (8%)	379	0.119 (1.00)	0.0303 (1.00)	1.51e-06 (0.000563)	0.317 (1.00)	0.0868 (1.00)
Amp Peak 31(16p11 2)	33 (8%)	377	0.195 (1.00)	0.00147 (0.465)	1.63e-14 (6.93e-12)	0.337 (1.00)	0.00291 (0.886)
Amp Peak 32(17p11 2)	14 (3%)	396	0.414 (1.00)	0.486 (1.00)	0.000398 (0.133)	0.39 (1.00)	0.0539 (1.00)
Amp Peak 33(17q11 2)	36 (9%)	374	0.0143 (1.00)	0.0031 (0.939)	6.25e-11 (2.56e-08)	0.261 (1.00)	0.158 (1.00)
Amp Peak 36(18q11 2)	32 (8%)	378	0.0135 (1.00)	0.00122 (0.388)	2.49e-08 (9.78e-06)	0.435 (1.00)	0.833 (1.00)
Amp Peak 40(20p13)	50 (12%)	360	0.171 (1.00)	0.0133 (1.00)	2.24e-06 (0.000832)	0.144 (1.00)	0.0819 (1.00)
Del Peak 1(1p36 31)	40 (10%)	370	0.368 (1.00)	0.00233 (0.721)	0.000403 (0.134)	0.476 (1.00)	0.179 (1.00)
Del Peak 3(2q22 1)	26 (6%)	384	3.39e-05 (0.012)	0.0308 (1.00)	0.00307 (0.934)	0.0276 (1.00)	1 (1.00)
Del Peak 12(7q11 22)	20 (5%)	390	0.395 (1.00)	0.00622 (1.00)	0.000254 (0.0863)	1 (1.00)	0.184 (1.00)
Del Peak 14(8p23 3)	62 (15%)	348	0.651 (1.00)	0.00605 (1.00)	5.71e-22 (2.5e-19)	0.659 (1.00)	0.0065 (1.00)
Del Peak 15(8p11 22)	31 (8%)	379	0.521 (1.00)	0.00108 (0.347)	1.69e-12 (7.04e-10)	0.842 (1.00)	0.033 (1.00)
Del Peak 38(18q23)	50 (12%)	360	0.075 (1.00)	0.00342 (1.00)	1.14e-07 (4.42e-05)	0.0238 (1.00)	0.729 (1.00)
Del Peak 40(19q13 43)	28 (7%)	382	0.00916 (1.00)	0.00082 (0.267)	1.14e-08 (4.53e-06)	0.677 (1.00)	0.0405 (1.00)
Amp Peak 2(1p22 3)	53 (13%)	357	0.878 (1.00)	0.224 (1.00)	0.271 (1.00)	0.753 (1.00)	0.5 (1.00)
Amp Peak 13(6q16 3)	32 (8%)	378	0.414 (1.00)	0.0885 (1.00)	0.00179 (0.563)	0.697 (1.00)	0.289 (1.00)
Amp Peak 14(7q22 1)	47 (11%)	363	0.00425 (1.00)	0.226 (1.00)	0.0861 (1.00)	0.0998 (1.00)	0.374 (1.00)
Amp Peak 15(8p11 22)	79 (19%)	331	0.00323 (0.974)	0.148 (1.00)	0.506 (1.00)	0.789 (1.00)	0.391 (1.00)
Amp Peak 21(10q22 2)	96 (23%)	314	0.344 (1.00)	0.437 (1.00)	0.128 (1.00)	1 (1.00)	0.504 (1.00)
Amp Peak 25(12p13 33)	43 (10%)	367	0.394 (1.00)	0.405 (1.00)	0.0024 (0.736)	1 (1.00)	0.14 (1.00)
Amp Peak 26(12q13 11)	46 (11%)	364	0.543 (1.00)	0.348 (1.00)	0.00181 (0.565)	1 (1.00)	0.595 (1.00)
Amp Peak 30(15q26 3)	17 (4%)	393	0.786 (1.00)	0.411 (1.00)	0.18 (1.00)	0.108 (1.00)	0.153 (1.00)
Del Peak 4(2q37 3)	24 (6%)	386	0.668 (1.00)	0.00726 (1.00)	0.119 (1.00)	0.826 (1.00)	0.224 (1.00)
Del Peak 10(6q26)	24 (6%)	386	0.555 (1.00)	0.0906 (1.00)	0.000876 (0.284)	0.652 (1.00)	1 (1.00)
Del Peak 18(10q21 2)	17 (4%)	393	0.776 (1.00)	0.347 (1.00)	0.0274 (1.00)	0.793 (1.00)	0.392 (1.00)
Del Peak 19(10q23 31)	36 (9%)	374	0.414 (1.00)	0.188 (1.00)	0.121 (1.00)	0.133 (1.00)	0.315 (1.00)
Del Peak 23(12q23 1)	19 (5%)	391	0.589 (1.00)	0.0495 (1.00)	0.0223 (1.00)	0.802 (1.00)	0.279 (1.00)
Del Peak 26(13q14 2)	45 (11%)	365	0.376 (1.00)	0.00277 (0.849)	0.0138 (1.00)	0.31 (1.00)	1 (1.00)
Del Peak 41(20p12 1)	19 (5%)	391	0.537 (1.00)	0.0078 (1.00)	0.155 (1.00)	1 (1.00)	1 (1.00)
Del Peak 42(20q13 12)	6 (1%)	404	0.536 (1.00)	0.0517 (1.00)	0.654 (1.00)	0.0855 (1.00)	1 (1.00)
Del Peak 43(22q11 1)	41 (10%)	369	0.787 (1.00)	0.00225 (0.697)	0.0748 (1.00)	0.296 (1.00)	0.346 (1.00)
Del Peak 44(22q12 1)	51 (12%)	359	0.475 (1.00)	0.0173 (1.00)	0.0254 (1.00)	0.2 (1.00)	0.171 (1.00)

'Amp Peak 1(1p34.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.09e-08 (Chi-square test), Q value = 4.3e-06

Table S1. Gene #1: 'Amp Peak 1(1p34.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 1(1P34.2) MUTATED	7	0	0	0	0	3	16
AMP PEAK 1(1P34.2) WILD-TYPE	299	3	8	2	7	14	51

Figure S1. Get High-res Image Gene #1: 'Amp Peak 1(1p34.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 3(1q21.3) mutation analysis' versus 'AGE'

P value = 0.000375 (t-test), Q value = 0.13

Table S2. Gene #3: 'Amp Peak 3(1q21.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 3(1Q21.3) MUTATED	160	65.8 (10.3)
AMP PEAK 3(1Q21.3) WILD-TYPE	249	61.9 (11.3)

Figure S2. Get High-res Image Gene #3: 'Amp Peak 3(1q21.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 4(1q22) mutation analysis' versus 'AGE'

P value = 3.1e-05 (t-test), Q value = 0.011

Table S3. Gene #4: 'Amp Peak 4(1q22) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 4(1Q22) MUTATED	170	66.1 (10.4)
AMP PEAK 4(1Q22) WILD-TYPE	239	61.5 (11.2)

Figure S3. Get High-res Image Gene #4: 'Amp Peak 4(1q22) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 5(2p23.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.63e-07 (Chi-square test), Q value = 1e-04

Table S4. Gene #5: 'Amp Peak 5(2p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 5(2P23.2) MUTATED	37	0	0	1	1	4	29
AMP PEAK 5(2P23.2) WILD-TYPE	269	3	8	1	6	13	38

Figure S4. Get High-res Image Gene #5: 'Amp Peak 5(2p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 6(2q13) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.69e-08 (Chi-square test), Q value = 1.8e-05

Table S5. Gene #6: 'Amp Peak 6(2q13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 6(2Q13) MUTATED	33	0	0	1	0	4	28
AMP PEAK 6(2Q13) WILD-TYPE	273	3	8	1	7	13	39

Figure S5. Get High-res Image Gene #6: 'Amp Peak 6(2q13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 7(3p25.1) mutation analysis' versus 'AGE'

P value = 0.000573 (t-test), Q value = 0.19

Table S6. Gene #7: 'Amp Peak 7(3p25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 7(3P25.1) MUTATED	48	68.9 (11.2)
AMP PEAK 7(3P25.1) WILD-TYPE	361	62.7 (10.9)

Figure S6. Get High-res Image Gene #7: 'Amp Peak 7(3p25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 7(3p25.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.33e-07 (Chi-square test), Q value = 0.00013

Table S7. Gene #7: 'Amp Peak 7(3p25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 7(3P25.1) MUTATED	23	0	0	0	1	1	23
AMP PEAK 7(3P25.1) WILD-TYPE	283	3	8	2	6	16	44

Figure S7. Get High-res Image Gene #7: 'Amp Peak 7(3p25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 8(3q26.2) mutation analysis' versus 'AGE'

P value = 1.47e-07 (t-test), Q value = 5.7e-05

Table S8. Gene #8: 'Amp Peak 8(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 8(3Q26.2) MUTATED	100	68.2 (9.9)
AMP PEAK 8(3Q26.2) WILD-TYPE	309	61.9 (11.1)

Figure S8. Get High-res Image Gene #8: 'Amp Peak 8(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 8(3q26.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.64e-18 (Chi-square test), Q value = 1.1e-15

Table S9. Gene #8: 'Amp Peak 8(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 8(3Q26.2) MUTATED	46	0	0	0	2	5	47
AMP PEAK 8(3Q26.2) WILD-TYPE	260	3	8	2	5	12	20

Figure S9. Get High-res Image Gene #8: 'Amp Peak 8(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 9(3q26.2) mutation analysis' versus 'AGE'

P value = 3.75e-05 (t-test), Q value = 0.013

Table S10. Gene #9: 'Amp Peak 9(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 9(3Q26.2) MUTATED	95	67.3 (9.9)
AMP PEAK 9(3Q26.2) WILD-TYPE	314	62.2 (11.2)

Figure S10. Get High-res Image Gene #9: 'Amp Peak 9(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 9(3q26.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.9e-19 (Chi-square test), Q value = 3.4e-16

Table S11. Gene #9: 'Amp Peak 9(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 9(3Q26.2) MUTATED	42	0	0	0	2	5	46
AMP PEAK 9(3Q26.2) WILD-TYPE	264	3	8	2	5	12	21

Figure S11. Get High-res Image Gene #9: 'Amp Peak 9(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 10(4p16.3) mutation analysis' versus 'AGE'

P value = 6.99e-06 (t-test), Q value = 0.0025

Table S12. Gene #10: 'Amp Peak 10(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 10(4P16.3) MUTATED	27	71.4 (7.8)
AMP PEAK 10(4P16.3) WILD-TYPE	382	62.9 (11.1)

Figure S12. Get High-res Image Gene #10: 'Amp Peak 10(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 10(4p16.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.53e-13 (Chi-square test), Q value = 1.1e-10

Table S13. Gene #10: 'Amp Peak 10(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 10(4P16.3) MUTATED	6	0	0	0	0	1	20
AMP PEAK 10(4P16.3) WILD-TYPE	300	3	8	2	7	16	47

Figure S13. Get High-res Image Gene #10: 'Amp Peak 10(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 11(5p15.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.55e-12 (Chi-square test), Q value = 2.7e-09

Table S14. Gene #11: 'Amp Peak 11(5p15.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 11(5P15.33) MUTATED	20	0	0	0	0	1	27
AMP PEAK 11(5P15.33) WILD-TYPE	286	3	8	2	7	16	40

Figure S14. Get High-res Image Gene #11: 'Amp Peak 11(5p15.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 12(6p24.2) mutation analysis' versus 'AGE'

P value = 0.000327 (t-test), Q value = 0.11

Table S15. Gene #12: 'Amp Peak 12(6p24.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 12(6P24.2) MUTATED	58	68.2 (10.3)
AMP PEAK 12(6P24.2) WILD-TYPE	351	62.6 (11.1)

Figure S15. Get High-res Image Gene #12: 'Amp Peak 12(6p24.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 12(6p24.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.53e-10 (Chi-square test), Q value = 6.3e-08

Table S16. Gene #12: 'Amp Peak 12(6p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 12(6P24.2) MUTATED	28	0	0	0	0	1	29
AMP PEAK 12(6P24.2) WILD-TYPE	278	3	8	2	7	16	38

Figure S16. Get High-res Image Gene #12: 'Amp Peak 12(6p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 16(8p11.21) mutation analysis' versus 'Time to Death'

P value = 4.98e-06 (logrank test), Q value = 0.0018

Table S17. Gene #16: 'Amp Peak 16(8p11.21) mutation analysis' versus Clinical Feature #1: 'Time to Death'

	nPatients	nDeath	Duration Range (Median), Month
ALL	407	40	0.0 - 187.1 (17.2)
AMP PEAK 16(8P11.21) MUTATED	98	20	0.5 - 113.2 (12.5)
AMP PEAK 16(8P11.21) WILD-TYPE	309	20	0.0 - 187.1 (18.1)

Figure S17. Get High-res Image Gene #16: 'Amp Peak 16(8p11.21) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Amp Peak 16(8p11.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000563 (Chi-square test), Q value = 0.19

Table S18. Gene #16: 'Amp Peak 16(8p11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 16(8P11.21) MUTATED	60	1	0	0	3	4	30
AMP PEAK 16(8P11.21) WILD-TYPE	246	2	8	2	4	13	37

Figure S18. Get High-res Image Gene #16: 'Amp Peak 16(8p11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 17(8q24.21) mutation analysis' versus 'Time to Death'

P value = 0.000637 (logrank test), Q value = 0.21

Table S19. Gene #17: 'Amp Peak 17(8q24.21) mutation analysis' versus Clinical Feature #1: 'Time to Death'

	nPatients	nDeath	Duration Range (Median), Month
ALL	407	40	0.0 - 187.1 (17.2)
AMP PEAK 17(8Q24.21) MUTATED	124	21	0.1 - 187.1 (13.8)
AMP PEAK 17(8Q24.21) WILD-TYPE	283	19	0.0 - 173.6 (17.9)

Figure S19. Get High-res Image Gene #17: 'Amp Peak 17(8q24.21) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Amp Peak 17(8q24.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.2e-08 (Chi-square test), Q value = 4.8e-06

Table S20. Gene #17: 'Amp Peak 17(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 17(8Q24.21) MUTATED	72	1	0	0	3	6	43
AMP PEAK 17(8Q24.21) WILD-TYPE	234	2	8	2	4	11	24

Figure S20. Get High-res Image Gene #17: 'Amp Peak 17(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 18(8q24.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.22e-09 (Chi-square test), Q value = 4.9e-07

Table S21. Gene #18: 'Amp Peak 18(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 18(8Q24.21) MUTATED	77	1	0	0	3	5	46
AMP PEAK 18(8Q24.21) WILD-TYPE	229	2	8	2	4	12	21

Figure S21. Get High-res Image Gene #18: 'Amp Peak 18(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 19(9p24.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.7e-06 (Chi-square test), Q value = 0.0028

Table S22. Gene #19: 'Amp Peak 19(9p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 19(9P24.2) MUTATED	16	0	0	0	0	0	17
AMP PEAK 19(9P24.2) WILD-TYPE	290	3	8	2	7	17	50

Figure S22. Get High-res Image Gene #19: 'Amp Peak 19(9p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 20(9q34.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.12e-07 (Chi-square test), Q value = 0.00034

Table S23. Gene #20: 'Amp Peak 20(9q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 20(9Q34.3) MUTATED	5	0	0	0	0	3	12
AMP PEAK 20(9Q34.3) WILD-TYPE	301	3	8	2	7	14	55

Figure S23. Get High-res Image Gene #20: 'Amp Peak 20(9q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 22(11p11.2) mutation analysis' versus 'AGE'

P value = 0.000598 (t-test), Q value = 0.2

Table S24. Gene #22: 'Amp Peak 22(11p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 22(11P11.2) MUTATED	23	71.3 (9.9)
AMP PEAK 22(11P11.2) WILD-TYPE	386	62.9 (11.0)

Figure S24. Get High-res Image Gene #22: 'Amp Peak 22(11p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 22(11p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.37e-08 (Chi-square test), Q value = 1.3e-05

Table S25. Gene #22: 'Amp Peak 22(11p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 22(11P11.2) MUTATED	6	0	0	0	0	2	15
AMP PEAK 22(11P11.2) WILD-TYPE	300	3	8	2	7	15	52

Figure S25. Get High-res Image Gene #22: 'Amp Peak 22(11p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 23(11q13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000101 (Chi-square test), Q value = 0.035

Table S26. Gene #23: 'Amp Peak 23(11q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 23(11Q13.2) MUTATED	16	0	0	0	0	1	16
AMP PEAK 23(11Q13.2) WILD-TYPE	290	3	8	2	7	16	51

Figure S26. Get High-res Image Gene #23: 'Amp Peak 23(11q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 24(11q22.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.74e-05 (Chi-square test), Q value = 0.034

Table S27. Gene #24: 'Amp Peak 24(11q22.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 24(11Q22.2) MUTATED	9	0	0	0	0	3	12
AMP PEAK 24(11Q22.2) WILD-TYPE	297	3	8	2	7	14	55

Figure S27. Get High-res Image Gene #24: 'Amp Peak 24(11q22.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 27(12q13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.11e-06 (Chi-square test), Q value = 0.0033

Table S28. Gene #27: 'Amp Peak 27(12q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 27(12Q13.2) MUTATED	27	0	0	0	0	1	22
AMP PEAK 27(12Q13.2) WILD-TYPE	279	3	8	2	7	16	45

Figure S28. Get High-res Image Gene #27: 'Amp Peak 27(12q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 28(14q24.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.57e-07 (Chi-square test), Q value = 0.00014

Table S29. Gene #28: 'Amp Peak 28(14q24.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 28(14Q24.3) MUTATED	11	0	0	0	0	2	17
AMP PEAK 28(14Q24.3) WILD-TYPE	295	3	8	2	7	15	50

Figure S29. Get High-res Image Gene #28: 'Amp Peak 28(14q24.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 29(14q32.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.51e-06 (Chi-square test), Q value = 0.00056

Table S30. Gene #29: 'Amp Peak 29(14q32.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 29(14Q32.33) MUTATED	14	0	0	0	0	0	17
AMP PEAK 29(14Q32.33) WILD-TYPE	292	3	8	2	7	17	50

Figure S30. Get High-res Image Gene #29: 'Amp Peak 29(14q32.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 31(16p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.63e-14 (Chi-square test), Q value = 6.9e-12

Table S31. Gene #31: 'Amp Peak 31(16p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 31(16P11.2) MUTATED	8	0	0	0	0	2	23
AMP PEAK 31(16P11.2) WILD-TYPE	298	3	8	2	7	15	44

Figure S31. Get High-res Image Gene #31: 'Amp Peak 31(16p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 32(17p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000398 (Chi-square test), Q value = 0.13

Table S32. Gene #32: 'Amp Peak 32(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 32(17P11.2) MUTATED	5	0	0	0	0	0	9
AMP PEAK 32(17P11.2) WILD-TYPE	301	3	8	2	7	17	58

Figure S32. Get High-res Image Gene #32: 'Amp Peak 32(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 33(17q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.25e-11 (Chi-square test), Q value = 2.6e-08

Table S33. Gene #33: 'Amp Peak 33(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 33(17Q11.2) MUTATED	10	0	0	0	1	5	20
AMP PEAK 33(17Q11.2) WILD-TYPE	296	3	8	2	6	12	47

Figure S33. Get High-res Image Gene #33: 'Amp Peak 33(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 34(17q12) mutation analysis' versus 'AGE'

P value = 4.53e-05 (t-test), Q value = 0.016

Table S34. Gene #34: 'Amp Peak 34(17q12) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 34(17Q12) MUTATED	46	69.2 (9.3)
AMP PEAK 34(17Q12) WILD-TYPE	363	62.7 (11.1)

Figure S34. Get High-res Image Gene #34: 'Amp Peak 34(17q12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 34(17q12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.44e-15 (Chi-square test), Q value = 6.1e-13

Table S35. Gene #34: 'Amp Peak 34(17q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 34(17Q12) MUTATED	13	0	1	0	0	4	28
AMP PEAK 34(17Q12) WILD-TYPE	293	3	7	2	7	13	39

Figure S35. Get High-res Image Gene #34: 'Amp Peak 34(17q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 35(17q21.32) mutation analysis' versus 'AGE'

P value = 2.52e-05 (t-test), Q value = 0.009

Table S36. Gene #35: 'Amp Peak 35(17q21.32) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 35(17Q21.32) MUTATED	36	70.0 (8.6)
AMP PEAK 35(17Q21.32) WILD-TYPE	373	62.8 (11.1)

Figure S36. Get High-res Image Gene #35: 'Amp Peak 35(17q21.32) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 35(17q21.32) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.74e-06 (Chi-square test), Q value = 0.0014

Table S37. Gene #35: 'Amp Peak 35(17q21.32) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 35(17Q21.32) MUTATED	15	0	0	0	0	4	17
AMP PEAK 35(17Q21.32) WILD-TYPE	291	3	8	2	7	13	50

Figure S37. Get High-res Image Gene #35: 'Amp Peak 35(17q21.32) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 36(18q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.49e-08 (Chi-square test), Q value = 9.8e-06

Table S38. Gene #36: 'Amp Peak 36(18q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 36(18Q11.2) MUTATED	10	0	0	0	1	3	18
AMP PEAK 36(18Q11.2) WILD-TYPE	296	3	8	2	6	14	49

Figure S38. Get High-res Image Gene #36: 'Amp Peak 36(18q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 37(19p13.2) mutation analysis' versus 'AGE'

P value = 2.3e-10 (t-test), Q value = 9.3e-08

Table S39. Gene #37: 'Amp Peak 37(19p13.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 37(19P13.2) MUTATED	49	71.7 (8.0)
AMP PEAK 37(19P13.2) WILD-TYPE	360	62.3 (11.0)

Figure S39. Get High-res Image Gene #37: 'Amp Peak 37(19p13.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 37(19p13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.1e-16 (Chi-square test), Q value = 3.4e-13

Table S40. Gene #37: 'Amp Peak 37(19p13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 37(19P13.2) MUTATED	14	0	0	0	1	6	28
AMP PEAK 37(19P13.2) WILD-TYPE	292	3	8	2	6	11	39

Figure S40. Get High-res Image Gene #37: 'Amp Peak 37(19p13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 38(19p13.13) mutation analysis' versus 'AGE'

P value = 4.88e-11 (t-test), Q value = 2e-08

Table S41. Gene #38: 'Amp Peak 38(19p13.13) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 38(19P13.13) MUTATED	53	71.6 (8.0)
AMP PEAK 38(19P13.13) WILD-TYPE	356	62.2 (11.0)

Figure S41. Get High-res Image Gene #38: 'Amp Peak 38(19p13.13) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 38(19p13.13) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.46e-19 (Chi-square test), Q value = 1.5e-16

Table S42. Gene #38: 'Amp Peak 38(19p13.13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 38(19P13.13) MUTATED	16	0	0	0	0	4	33
AMP PEAK 38(19P13.13) WILD-TYPE	290	3	8	2	7	13	34

Figure S42. Get High-res Image Gene #38: 'Amp Peak 38(19p13.13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 39(19q12) mutation analysis' versus 'AGE'

P value = 8.84e-07 (t-test), Q value = 0.00033

Table S43. Gene #39: 'Amp Peak 39(19q12) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 39(19Q12) MUTATED	49	68.9 (7.1)
AMP PEAK 39(19Q12) WILD-TYPE	360	62.7 (11.4)

Figure S43. Get High-res Image Gene #39: 'Amp Peak 39(19q12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 39(19q12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.08e-24 (Chi-square test), Q value = 2.7e-21

Table S44. Gene #39: 'Amp Peak 39(19q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 39(19Q12) MUTATED	10	0	0	0	0	6	33
AMP PEAK 39(19Q12) WILD-TYPE	296	3	8	2	7	11	34

Figure S44. Get High-res Image Gene #39: 'Amp Peak 39(19q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 39(19q12) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 3.68e-05 (Fisher's exact test), Q value = 0.013

Table S45. Gene #39: 'Amp Peak 39(19q12) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients	NO	YES
ALL	306	104
AMP PEAK 39(19Q12) MUTATED	24	25
AMP PEAK 39(19Q12) WILD-TYPE	282	79

Figure S45. Get High-res Image Gene #39: 'Amp Peak 39(19q12) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Amp Peak 40(20p13) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.24e-06 (Chi-square test), Q value = 0.00083

Table S46. Gene #40: 'Amp Peak 40(20p13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 40(20P13) MUTATED	25	0	0	1	0	2	22
AMP PEAK 40(20P13) WILD-TYPE	281	3	8	1	7	15	45

Figure S46. Get High-res Image Gene #40: 'Amp Peak 40(20p13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 41(20q11.21) mutation analysis' versus 'AGE'

P value = 0.000187 (t-test), Q value = 0.064

Table S47. Gene #41: 'Amp Peak 41(20q11.21) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 41(20Q11.21) MUTATED	65	67.6 (9.1)
AMP PEAK 41(20Q11.21) WILD-TYPE	344	62.6 (11.3)

Figure S47. Get High-res Image Gene #41: 'Amp Peak 41(20q11.21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 41(20q11.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.37e-20 (Chi-square test), Q value = 3.2e-17

Table S48. Gene #41: 'Amp Peak 41(20q11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 41(20Q11.21) MUTATED	22	0	0	1	0	5	37
AMP PEAK 41(20Q11.21) WILD-TYPE	284	3	8	1	7	12	30

Figure S48. Get High-res Image Gene #41: 'Amp Peak 41(20q11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 42(20q13.12) mutation analysis' versus 'AGE'

P value = 7.44e-05 (t-test), Q value = 0.026

Table S49. Gene #42: 'Amp Peak 42(20q13.12) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 42(20Q13.12) MUTATED	67	68.2 (10.1)
AMP PEAK 42(20Q13.12) WILD-TYPE	342	62.5 (11.1)

Figure S49. Get High-res Image Gene #42: 'Amp Peak 42(20q13.12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 42(20q13.12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.15e-18 (Chi-square test), Q value = 1.4e-15

Table S50. Gene #42: 'Amp Peak 42(20q13.12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 42(20Q13.12) MUTATED	24	0	0	1	1	4	37
AMP PEAK 42(20Q13.12) WILD-TYPE	282	3	8	1	6	13	30

Figure S50. Get High-res Image Gene #42: 'Amp Peak 42(20q13.12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 43(20q13.33) mutation analysis' versus 'AGE'

P value = 0.000195 (t-test), Q value = 0.067

Table S51. Gene #43: 'Amp Peak 43(20q13.33) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
AMP PEAK 43(20Q13.33) MUTATED	68	67.8 (10.2)
AMP PEAK 43(20Q13.33) WILD-TYPE	341	62.5 (11.1)

Figure S51. Get High-res Image Gene #43: 'Amp Peak 43(20q13.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 43(20q13.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.95e-11 (Chi-square test), Q value = 8.1e-09

Table S52. Gene #43: 'Amp Peak 43(20q13.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
AMP PEAK 43(20Q13.33) MUTATED	30	0	0	1	2	3	32
AMP PEAK 43(20Q13.33) WILD-TYPE	276	3	8	1	5	14	35

Figure S52. Get High-res Image Gene #43: 'Amp Peak 43(20q13.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 1(1p36.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000403 (Chi-square test), Q value = 0.13

Table S53. Gene #44: 'Del Peak 1(1p36.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 1(1P36.31) MUTATED	20	0	0	0	0	4	16
DEL PEAK 1(1P36.31) WILD-TYPE	286	3	8	2	7	13	51

Figure S53. Get High-res Image Gene #44: 'Del Peak 1(1p36.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 2(1p36.11) mutation analysis' versus 'AGE'

P value = 0.000629 (t-test), Q value = 0.21

Table S54. Gene #45: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 2(1P36.11) MUTATED	46	68.1 (9.2)
DEL PEAK 2(1P36.11) WILD-TYPE	363	62.8 (11.2)

Figure S54. Get High-res Image Gene #45: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 2(1p36.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.65e-10 (Chi-square test), Q value = 2.3e-07

Table S55. Gene #45: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 2(1P36.11) MUTATED	18	0	0	0	0	4	24
DEL PEAK 2(1P36.11) WILD-TYPE	288	3	8	2	7	13	43

Figure S55. Get High-res Image Gene #45: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 3(2q22.1) mutation analysis' versus 'Time to Death'

P value = 3.39e-05 (logrank test), Q value = 0.012

Table S56. Gene #46: 'Del Peak 3(2q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

	nPatients	nDeath	Duration Range (Median), Month
ALL	407	40	0.0 - 187.1 (17.2)
DEL PEAK 3(2Q22.1) MUTATED	26	7	0.5 - 113.2 (8.3)
DEL PEAK 3(2Q22.1) WILD-TYPE	381	33	0.0 - 187.1 (18.1)

Figure S56. Get High-res Image Gene #46: 'Del Peak 3(2q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Del Peak 5(3p14.2) mutation analysis' versus 'AGE'

P value = 2.97e-05 (t-test), Q value = 0.011

Table S57. Gene #48: 'Del Peak 5(3p14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 5(3P14.2) MUTATED	40	68.7 (7.4)
DEL PEAK 5(3P14.2) WILD-TYPE	369	62.8 (11.3)

Figure S57. Get High-res Image Gene #48: 'Del Peak 5(3p14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 5(3p14.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.56e-10 (Chi-square test), Q value = 1.8e-07

Table S58. Gene #48: 'Del Peak 5(3p14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 5(3P14.2) MUTATED	13	0	0	0	1	5	21
DEL PEAK 5(3P14.2) WILD-TYPE	293	3	8	2	6	12	46

Figure S58. Get High-res Image Gene #48: 'Del Peak 5(3p14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 6(4p16.3) mutation analysis' versus 'AGE'

P value = 0.000132 (t-test), Q value = 0.045

Table S59. Gene #49: 'Del Peak 6(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 6(4P16.3) MUTATED	45	68.4 (8.3)
DEL PEAK 6(4P16.3) WILD-TYPE	364	62.8 (11.3)

Figure S59. Get High-res Image Gene #49: 'Del Peak 6(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 6(4p16.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.8e-11 (Chi-square test), Q value = 1.6e-08

Table S60. Gene #49: 'Del Peak 6(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 6(4P16.3) MUTATED	16	0	0	0	1	3	25
DEL PEAK 6(4P16.3) WILD-TYPE	290	3	8	2	6	14	42

Figure S60. Get High-res Image Gene #49: 'Del Peak 6(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 7(4q22.1) mutation analysis' versus 'AGE'

P value = 0.000763 (t-test), Q value = 0.25

Table S61. Gene #50: 'Del Peak 7(4q22.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 7(4Q22.1) MUTATED	46	68.1 (9.3)
DEL PEAK 7(4Q22.1) WILD-TYPE	363	62.8 (11.2)

Figure S61. Get High-res Image Gene #50: 'Del Peak 7(4q22.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 7(4q22.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.18e-12 (Chi-square test), Q value = 5e-10

Table S62. Gene #50: 'Del Peak 7(4q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 7(4Q22.1) MUTATED	15	0	0	0	1	4	26
DEL PEAK 7(4Q22.1) WILD-TYPE	291	3	8	2	6	13	41

Figure S62. Get High-res Image Gene #50: 'Del Peak 7(4q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 8(4q34.3) mutation analysis' versus 'AGE'

P value = 6.48e-05 (t-test), Q value = 0.023

Table S63. Gene #51: 'Del Peak 8(4q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 8(4Q34.3) MUTATED	63	67.9 (8.8)
DEL PEAK 8(4Q34.3) WILD-TYPE	346	62.6 (11.3)

Figure S63. Get High-res Image Gene #51: 'Del Peak 8(4q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 8(4q34.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.04e-17 (Chi-square test), Q value = 1.3e-14

Table S64. Gene #51: 'Del Peak 8(4q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 8(4Q34.3) MUTATED	21	0	0	0	2	6	34
DEL PEAK 8(4Q34.3) WILD-TYPE	285	3	8	2	5	11	33

Figure S64. Get High-res Image Gene #51: 'Del Peak 8(4q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 9(5q11.2) mutation analysis' versus 'AGE'

P value = 7.98e-05 (t-test), Q value = 0.028

Table S65. Gene #52: 'Del Peak 9(5q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 9(5Q11.2) MUTATED	53	68.2 (8.5)
DEL PEAK 9(5Q11.2) WILD-TYPE	356	62.7 (11.3)

Figure S65. Get High-res Image Gene #52: 'Del Peak 9(5q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 9(5q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.13e-21 (Chi-square test), Q value = 4.9e-19

Table S66. Gene #52: 'Del Peak 9(5q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 9(5Q11.2) MUTATED	17	0	0	0	1	0	35
DEL PEAK 9(5Q11.2) WILD-TYPE	289	3	8	2	6	17	32

Figure S66. Get High-res Image Gene #52: 'Del Peak 9(5q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 11(7p22.3) mutation analysis' versus 'AGE'

P value = 0.000118 (t-test), Q value = 0.041

Table S67. Gene #54: 'Del Peak 11(7p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 11(7P22.3) MUTATED	43	69.3 (9.8)
DEL PEAK 11(7P22.3) WILD-TYPE	366	62.7 (11.1)

Figure S67. Get High-res Image Gene #54: 'Del Peak 11(7p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 11(7p22.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.65e-10 (Chi-square test), Q value = 1.1e-07

Table S68. Gene #54: 'Del Peak 11(7p22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 11(7P22.3) MUTATED	16	0	0	0	1	3	24
DEL PEAK 11(7P22.3) WILD-TYPE	290	3	8	2	6	14	43

Figure S68. Get High-res Image Gene #54: 'Del Peak 11(7p22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 12(7q11.22) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000254 (Chi-square test), Q value = 0.086

Table S69. Gene #55: 'Del Peak 12(7q11.22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 12(7Q11.22) MUTATED	7	0	0	0	1	1	11
DEL PEAK 12(7Q11.22) WILD-TYPE	299	3	8	2	6	16	56

Figure S69. Get High-res Image Gene #55: 'Del Peak 12(7q11.22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 13(7q36.1) mutation analysis' versus 'AGE'

P value = 1.15e-06 (t-test), Q value = 0.00043

Table S70. Gene #56: 'Del Peak 13(7q36.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 13(7Q36.1) MUTATED	40	70.1 (7.8)
DEL PEAK 13(7Q36.1) WILD-TYPE	369	62.7 (11.2)

Figure S70. Get High-res Image Gene #56: 'Del Peak 13(7q36.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 13(7q36.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.81e-20 (Chi-square test), Q value = 3e-17

Table S71. Gene #56: 'Del Peak 13(7q36.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 13(7Q36.1) MUTATED	7	0	0	0	1	4	28
DEL PEAK 13(7Q36.1) WILD-TYPE	299	3	8	2	6	13	39

Figure S71. Get High-res Image Gene #56: 'Del Peak 13(7q36.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 14(8p23.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.71e-22 (Chi-square test), Q value = 2.5e-19

Table S72. Gene #57: 'Del Peak 14(8p23.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 14(8P23.3) MUTATED	19	0	0	0	2	3	38
DEL PEAK 14(8P23.3) WILD-TYPE	287	3	8	2	5	14	29

Figure S72. Get High-res Image Gene #57: 'Del Peak 14(8p23.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 15(8p11.22) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.69e-12 (Chi-square test), Q value = 7e-10

Table S73. Gene #58: 'Del Peak 15(8p11.22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 15(8P11.22) MUTATED	8	0	0	0	0	2	21
DEL PEAK 15(8P11.22) WILD-TYPE	298	3	8	2	7	15	46

Figure S73. Get High-res Image Gene #58: 'Del Peak 15(8p11.22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 16(9p23) mutation analysis' versus 'AGE'

P value = 0.000322 (t-test), Q value = 0.11

Table S74. Gene #59: 'Del Peak 16(9p23) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 16(9P23) MUTATED	36	68.7 (8.3)
DEL PEAK 16(9P23) WILD-TYPE	373	62.9 (11.2)

Figure S74. Get High-res Image Gene #59: 'Del Peak 16(9p23) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 16(9p23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.95e-08 (Chi-square test), Q value = 1.2e-05

Table S75. Gene #59: 'Del Peak 16(9p23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 16(9P23) MUTATED	14	0	0	0	0	2	20
DEL PEAK 16(9P23) WILD-TYPE	292	3	8	2	7	15	47

Figure S75. Get High-res Image Gene #59: 'Del Peak 16(9p23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 17(9q34.11) mutation analysis' versus 'AGE'

P value = 2.51e-08 (t-test), Q value = 9.8e-06

Table S76. Gene #60: 'Del Peak 17(9q34.11) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 17(9Q34.11) MUTATED	75	69.1 (8.6)
DEL PEAK 17(9Q34.11) WILD-TYPE	334	62.2 (11.2)

Figure S76. Get High-res Image Gene #60: 'Del Peak 17(9q34.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 17(9q34.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.51e-10 (Chi-square test), Q value = 6.2e-08

Table S77. Gene #60: 'Del Peak 17(9q34.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 17(9Q34.11) MUTATED	35	0	0	0	2	5	33
DEL PEAK 17(9Q34.11) WILD-TYPE	271	3	8	2	5	12	34

Figure S77. Get High-res Image Gene #60: 'Del Peak 17(9q34.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 20(11p15.5) mutation analysis' versus 'AGE'

P value = 2.26e-06 (t-test), Q value = 0.00084

Table S78. Gene #63: 'Del Peak 20(11p15.5) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 20(11P15.5) MUTATED	54	69.3 (8.7)
DEL PEAK 20(11P15.5) WILD-TYPE	355	62.5 (11.2)

Figure S78. Get High-res Image Gene #63: 'Del Peak 20(11p15.5) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 20(11p15.5) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.63e-12 (Chi-square test), Q value = 1.1e-09

Table S79. Gene #63: 'Del Peak 20(11p15.5) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 20(11P15.5) MUTATED	21	0	0	0	1	3	29
DEL PEAK 20(11P15.5) WILD-TYPE	285	3	8	2	6	14	38

Figure S79. Get High-res Image Gene #63: 'Del Peak 20(11p15.5) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 21(11q14.1) mutation analysis' versus 'AGE'

P value = 0.00034 (t-test), Q value = 0.11

Table S80. Gene #64: 'Del Peak 21(11q14.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 21(11Q14.1) MUTATED	38	68.7 (8.7)
DEL PEAK 21(11Q14.1) WILD-TYPE	371	62.9 (11.2)

Figure S80. Get High-res Image Gene #64: 'Del Peak 21(11q14.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 21(11q14.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.63e-08 (Chi-square test), Q value = 6.4e-06

Table S81. Gene #64: 'Del Peak 21(11q14.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 21(11Q14.1) MUTATED	14	0	0	0	0	5	19
DEL PEAK 21(11Q14.1) WILD-TYPE	292	3	8	2	7	12	48

Figure S81. Get High-res Image Gene #64: 'Del Peak 21(11q14.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 22(11q24.2) mutation analysis' versus 'AGE'

P value = 7.03e-05 (t-test), Q value = 0.025

Table S82. Gene #65: 'Del Peak 22(11q24.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 22(11Q24.2) MUTATED	48	68.5 (8.6)
DEL PEAK 22(11Q24.2) WILD-TYPE	361	62.7 (11.2)

Figure S82. Get High-res Image Gene #65: 'Del Peak 22(11q24.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 22(11q24.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.84e-09 (Chi-square test), Q value = 3.1e-06

Table S83. Gene #65: 'Del Peak 22(11q24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 22(11Q24.2) MUTATED	20	0	0	0	0	5	23
DEL PEAK 22(11Q24.2) WILD-TYPE	286	3	8	2	7	12	44

Figure S83. Get High-res Image Gene #65: 'Del Peak 22(11q24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 24(12q24.33) mutation analysis' versus 'AGE'

P value = 0.000398 (t-test), Q value = 0.13

Table S84. Gene #67: 'Del Peak 24(12q24.33) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 24(12Q24.33) MUTATED	26	69.5 (7.9)
DEL PEAK 24(12Q24.33) WILD-TYPE	383	63.0 (11.2)

Figure S84. Get High-res Image Gene #67: 'Del Peak 24(12q24.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 24(12q24.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.81e-06 (Chi-square test), Q value = 0.0014

Table S85. Gene #67: 'Del Peak 24(12q24.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 24(12Q24.33) MUTATED	10	0	0	0	0	1	15
DEL PEAK 24(12Q24.33) WILD-TYPE	296	3	8	2	7	16	52

Figure S85. Get High-res Image Gene #67: 'Del Peak 24(12q24.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 25(13q11) mutation analysis' versus 'AGE'

P value = 0.000346 (t-test), Q value = 0.12

Table S86. Gene #68: 'Del Peak 25(13q11) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 25(13Q11) MUTATED	43	68.3 (8.7)
DEL PEAK 25(13Q11) WILD-TYPE	366	62.8 (11.2)

Figure S86. Get High-res Image Gene #68: 'Del Peak 25(13q11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 25(13q11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2e-06 (Chi-square test), Q value = 0.00074

Table S87. Gene #68: 'Del Peak 25(13q11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 25(13Q11) MUTATED	19	0	0	0	2	2	20
DEL PEAK 25(13Q11) WILD-TYPE	287	3	8	2	5	15	47

Figure S87. Get High-res Image Gene #68: 'Del Peak 25(13q11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 27(14q13.1) mutation analysis' versus 'AGE'

P value = 3.65e-05 (t-test), Q value = 0.013

Table S88. Gene #70: 'Del Peak 27(14q13.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 27(14Q13.1) MUTATED	34	69.7 (8.1)
DEL PEAK 27(14Q13.1) WILD-TYPE	375	62.8 (11.2)

Figure S88. Get High-res Image Gene #70: 'Del Peak 27(14q13.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 27(14q13.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.3e-07 (Chi-square test), Q value = 0.00024

Table S89. Gene #70: 'Del Peak 27(14q13.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 27(14Q13.1) MUTATED	13	0	0	0	0	4	17
DEL PEAK 27(14Q13.1) WILD-TYPE	293	3	8	2	7	13	50

Figure S89. Get High-res Image Gene #70: 'Del Peak 27(14q13.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 28(15q15.1) mutation analysis' versus 'AGE'

P value = 1.26e-06 (t-test), Q value = 0.00047

Table S90. Gene #71: 'Del Peak 28(15q15.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 28(15Q15.1) MUTATED	73	68.4 (8.8)
DEL PEAK 28(15Q15.1) WILD-TYPE	336	62.3 (11.3)

Figure S90. Get High-res Image Gene #71: 'Del Peak 28(15q15.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 28(15q15.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.73e-10 (Chi-square test), Q value = 7.1e-08

Table S91. Gene #71: 'Del Peak 28(15q15.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 28(15Q15.1) MUTATED	33	0	0	0	2	7	31
DEL PEAK 28(15Q15.1) WILD-TYPE	273	3	8	2	5	10	36

Figure S91. Get High-res Image Gene #71: 'Del Peak 28(15q15.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 29(15q23) mutation analysis' versus 'AGE'

P value = 5.07e-06 (t-test), Q value = 0.0018

Table S92. Gene #72: 'Del Peak 29(15q23) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 29(15Q23) MUTATED	57	69.1 (9.2)
DEL PEAK 29(15Q23) WILD-TYPE	352	62.5 (11.1)

Figure S92. Get High-res Image Gene #72: 'Del Peak 29(15q23) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 29(15q23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.91e-11 (Chi-square test), Q value = 7.9e-09

Table S93. Gene #72: 'Del Peak 29(15q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 29(15Q23) MUTATED	22	0	0	0	2	5	28
DEL PEAK 29(15Q23) WILD-TYPE	284	3	8	2	5	12	39

Figure S93. Get High-res Image Gene #72: 'Del Peak 29(15q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 30(16p13.3) mutation analysis' versus 'AGE'

P value = 9.23e-07 (t-test), Q value = 0.00035

Table S94. Gene #73: 'Del Peak 30(16p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 30(16P13.3) MUTATED	43	70.0 (8.0)
DEL PEAK 30(16P13.3) WILD-TYPE	366	62.7 (11.2)

Figure S94. Get High-res Image Gene #73: 'Del Peak 30(16p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 30(16p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.01e-07 (Chi-square test), Q value = 0.00015

Table S95. Gene #73: 'Del Peak 30(16p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 30(16P13.3) MUTATED	19	0	0	0	0	3	21
DEL PEAK 30(16P13.3) WILD-TYPE	287	3	8	2	7	14	46

Figure S95. Get High-res Image Gene #73: 'Del Peak 30(16p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 31(16q22.3) mutation analysis' versus 'AGE'

P value = 8.7e-08 (t-test), Q value = 3.4e-05

Table S96. Gene #74: 'Del Peak 31(16q22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 31(16Q22.3) MUTATED	95	67.9 (8.2)
DEL PEAK 31(16Q22.3) WILD-TYPE	314	62.1 (11.5)

Figure S96. Get High-res Image Gene #74: 'Del Peak 31(16q22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 31(16q22.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.46e-16 (Chi-square test), Q value = 1.5e-13

Table S97. Gene #74: 'Del Peak 31(16q22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 31(16Q22.3) MUTATED	45	0	0	0	1	5	44
DEL PEAK 31(16Q22.3) WILD-TYPE	261	3	8	2	6	12	23

Figure S97. Get High-res Image Gene #74: 'Del Peak 31(16q22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 32(16q23.1) mutation analysis' versus 'AGE'

P value = 1.27e-08 (t-test), Q value = 5e-06

Table S98. Gene #75: 'Del Peak 32(16q23.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 32(16Q23.1) MUTATED	100	68.1 (8.2)
DEL PEAK 32(16Q23.1) WILD-TYPE	309	61.9 (11.5)

Figure S98. Get High-res Image Gene #75: 'Del Peak 32(16q23.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 32(16q23.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.62e-19 (Chi-square test), Q value = 1.6e-16

Table S99. Gene #75: 'Del Peak 32(16q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 32(16Q23.1) MUTATED	47	0	0	0	1	4	48
DEL PEAK 32(16Q23.1) WILD-TYPE	259	3	8	2	6	13	19

Figure S99. Get High-res Image Gene #75: 'Del Peak 32(16q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 33(17p13.3) mutation analysis' versus 'AGE'

P value = 2.14e-05 (t-test), Q value = 0.0077

Table S100. Gene #76: 'Del Peak 33(17p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 33(17P13.3) MUTATED	61	67.8 (7.7)
DEL PEAK 33(17P13.3) WILD-TYPE	348	62.7 (11.5)

Figure S100. Get High-res Image Gene #76: 'Del Peak 33(17p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 33(17p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.17e-11 (Chi-square test), Q value = 4.9e-09

Table S101. Gene #76: 'Del Peak 33(17p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 33(17P13.3) MUTATED	24	0	0	0	2	7	28
DEL PEAK 33(17P13.3) WILD-TYPE	282	3	8	2	5	10	39

Figure S101. Get High-res Image Gene #76: 'Del Peak 33(17p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 34(17p11.2) mutation analysis' versus 'AGE'

P value = 4.2e-07 (t-test), Q value = 0.00016

Table S102. Gene #77: 'Del Peak 34(17p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 34(17P11.2) MUTATED	71	68.5 (8.3)
DEL PEAK 34(17P11.2) WILD-TYPE	338	62.3 (11.3)

Figure S102. Get High-res Image Gene #77: 'Del Peak 34(17p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 34(17p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.8e-22 (Chi-square test), Q value = 1.2e-19

Table S103. Gene #77: 'Del Peak 34(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 34(17P11.2) MUTATED	23	0	0	0	1	7	40
DEL PEAK 34(17P11.2) WILD-TYPE	283	3	8	2	6	10	27

Figure S103. Get High-res Image Gene #77: 'Del Peak 34(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 35(17p11.2) mutation analysis' versus 'AGE'

P value = 2.37e-06 (t-test), Q value = 0.00087

Table S104. Gene #78: 'Del Peak 35(17p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 35(17P11.2) MUTATED	64	68.4 (8.2)
DEL PEAK 35(17P11.2) WILD-TYPE	345	62.5 (11.3)

Figure S104. Get High-res Image Gene #78: 'Del Peak 35(17p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 35(17p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.33e-14 (Chi-square test), Q value = 1.4e-11

Table S105. Gene #78: 'Del Peak 35(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 35(17P11.2) MUTATED	25	0	0	0	1	5	33
DEL PEAK 35(17P11.2) WILD-TYPE	281	3	8	2	6	12	34

Figure S105. Get High-res Image Gene #78: 'Del Peak 35(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 36(17q11.2) mutation analysis' versus 'AGE'

P value = 1.28e-05 (t-test), Q value = 0.0046

Table S106. Gene #79: 'Del Peak 36(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 36(17Q11.2) MUTATED	60	68.1 (8.0)
DEL PEAK 36(17Q11.2) WILD-TYPE	349	62.6 (11.4)

Figure S106. Get High-res Image Gene #79: 'Del Peak 36(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 36(17q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.19e-09 (Chi-square test), Q value = 1.3e-06

Table S107. Gene #79: 'Del Peak 36(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 36(17Q11.2) MUTATED	26	0	0	0	2	5	27
DEL PEAK 36(17Q11.2) WILD-TYPE	280	3	8	2	5	12	40

Figure S107. Get High-res Image Gene #79: 'Del Peak 36(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 37(17q21.2) mutation analysis' versus 'AGE'

P value = 5.37e-06 (t-test), Q value = 0.002

Table S108. Gene #80: 'Del Peak 37(17q21.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 37(17Q21.2) MUTATED	61	68.7 (8.9)
DEL PEAK 37(17Q21.2) WILD-TYPE	348	62.5 (11.2)

Figure S108. Get High-res Image Gene #80: 'Del Peak 37(17q21.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 37(17q21.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.87e-10 (Chi-square test), Q value = 1.2e-07

Table S109. Gene #80: 'Del Peak 37(17q21.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 37(17Q21.2) MUTATED	26	0	0	0	1	6	28
DEL PEAK 37(17Q21.2) WILD-TYPE	280	3	8	2	6	11	39

Figure S109. Get High-res Image Gene #80: 'Del Peak 37(17q21.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 38(18q23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.14e-07 (Chi-square test), Q value = 4.4e-05

Table S110. Gene #81: 'Del Peak 38(18q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 38(18Q23) MUTATED	21	0	0	0	2	5	22
DEL PEAK 38(18Q23) WILD-TYPE	285	3	8	2	5	12	45

Figure S110. Get High-res Image Gene #81: 'Del Peak 38(18q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 39(19p13.3) mutation analysis' versus 'AGE'

P value = 3.14e-13 (t-test), Q value = 1.3e-10

Table S111. Gene #82: 'Del Peak 39(19p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 39(19P13.3) MUTATED	95	69.6 (8.0)
DEL PEAK 39(19P13.3) WILD-TYPE	314	61.6 (11.3)

Figure S111. Get High-res Image Gene #82: 'Del Peak 39(19p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 39(19p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.86e-42 (Chi-square test), Q value = 1.3e-39

Table S112. Gene #82: 'Del Peak 39(19p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 39(19P13.3) MUTATED	27	0	0	0	1	7	60
DEL PEAK 39(19P13.3) WILD-TYPE	279	3	8	2	6	10	7

Figure S112. Get High-res Image Gene #82: 'Del Peak 39(19p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 40(19q13.43) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.14e-08 (Chi-square test), Q value = 4.5e-06

Table S113. Gene #83: 'Del Peak 40(19q13.43) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 40(19Q13.43) MUTATED	8	0	0	0	0	4	16
DEL PEAK 40(19Q13.43) WILD-TYPE	298	3	8	2	7	13	51

Figure S113. Get High-res Image Gene #83: 'Del Peak 40(19q13.43) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 45(22q13.32) mutation analysis' versus 'AGE'

P value = 1.84e-07 (t-test), Q value = 7.1e-05

Table S114. Gene #88: 'Del Peak 45(22q13.32) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	409	63.4 (11.1)
DEL PEAK 45(22Q13.32) MUTATED	79	68.9 (9.5)
DEL PEAK 45(22Q13.32) WILD-TYPE	330	62.1 (11.1)

Figure S114. Get High-res Image Gene #88: 'Del Peak 45(22q13.32) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 45(22q13.32) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.43e-13 (Chi-square test), Q value = 1e-10

Table S115. Gene #88: 'Del Peak 45(22q13.32) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	306	3	8	2	7	17	67
DEL PEAK 45(22Q13.32) MUTATED	36	0	0	0	1	5	37
DEL PEAK 45(22Q13.32) WILD-TYPE	270	3	8	2	6	12	30

Figure S115. Get High-res Image Gene #88: 'Del Peak 45(22q13.32) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

Methods & Data

Input

Copy number data file = All Lesions File (all_lesions.conf_##.txt, where ## is the confidence level). The all lesions file is from GISTIC pipeline and summarizes the results from the GISTIC run. It contains data about the significant regions of amplification and deletion as well as which samples are amplified or deleted in each of these regions. The identified regions are listed down the first column, and the samples are listed across the first row, starting in column 10.
Clinical data file = UCEC.clin.merged.picked.txt
Number of patients = 410
Number of copy number variation regions = 88
Number of selected clinical features = 5
Exclude regions that fewer than K tumors have alterations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene cnvs were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene cnvs using 't.test' function in R

Chi-square test

For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.

References

[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)

[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)

[3] Greenwood and Nikulin, A guide to chi-squared testing, Wiley, New York. ISBN 047155779X (1996)

[4] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)

[5] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)

[6] GISTIC_version2

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