Uterine Corpus Endometrioid Carcinoma: Correlation between copy number variation genes and selected clinical features

Maintained by TCGA GDAC Team (Broad Institute/Dana-Farber Cancer Institute/Harvard Medical School)

Overview

Introduction

This pipeline computes the correlation between significant copy number variation (cnv) genes and selected clinical features.

Summary

Testing the association between copy number variation of 97 peak regions and 5 clinical features across 422 patients, 148 significant findings detected with Q value < 0.25.

Amp Peak 1(1p35.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 2(1p34.3) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 4(1q21.3) cnvs correlated to 'AGE'.
Amp Peak 5(1q22) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 7(2p23.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 8(2q13) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 9(3p25.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 10(3q26.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 11(4p16.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 12(5p15.33) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 13(6p24.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 14(6q25.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 15(7q32.2) cnvs correlated to 'Time to Death'.
Amp Peak 16(8p11.21) cnvs correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.
Amp Peak 17(8q24.21) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 18(8q24.21) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 19(9p24.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 20(9q34.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 22(11p11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 23(11q13.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 25(12p12.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 26(12q13.11) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 27(12q13.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 28(13q34) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 29(14q24.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 30(14q32.33) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 32(16p11.2) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.
Amp Peak 33(17p13.3) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 34(17q11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 35(17q12) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 36(17q21.32) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 37(17q25.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 38(18q11.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 39(19p13.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 40(19p13.11) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 41(19q12) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.
Amp Peak 42(20p13) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 43(20q11.21) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 44(20q13.33) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 45(22q12.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 1(1p36.21) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 2(1p36.11) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 5(2q22.1) cnvs correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.
Del Peak 6(2q37.3) cnvs correlated to 'AGE'.
Del Peak 7(3p14.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 8(4p16.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 9(4q22.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 10(4q34.3) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.
Del Peak 11(5q11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 12(6q26) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 13(7p22.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 14(7q31.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 15(7q36.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 16(8p23.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 17(8p21.2) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.
Del Peak 18(9p23) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 19(9q21.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 20(9q34.11) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 21(10p12.31) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 23(10q23.31) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 24(11p15.5) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 25(11q14.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 26(11q25) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 27(12q23.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 28(12q24.33) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 29(13q14.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 30(14q13.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 31(15q15.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 32(15q23) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 33(16p13.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 34(16q21) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 35(16q22.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 36(16q23.1) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.
Del Peak 37(17p13.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 38(17p11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 39(17q11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 40(17q21.31) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 41(18q23) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 42(19p13.3) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.
Del Peak 43(19p12) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 44(19q13.43) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 48(22q12.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 49(22q13.31) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 50(Xp21.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

Results

Overview of the results

Table 1. Get Full Table Overview of the association between significant copy number variation of 97 regions and 5 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 148 significant findings detected.


		Clinical Features	Time to Death	AGE	HISTOLOGICAL TYPE	RADIATIONS RADIATION REGIMENINDICATION	NEOADJUVANT THERAPY
	nCNV (%)	nWild-Type	logrank test	t-test	Chi-square test	Fisher's exact test	Fisher's exact test
Amp Peak 32(16p11 2)	44 (10%)	378	0.193 (1.00)	0.00039 (0.133)	7.5e-14 (3.38e-11)	1 (1.00)	0.000134 (0.0484)
Amp Peak 41(19q12)	77 (18%)	345	0.00505 (1.00)	1.7e-09 (7.15e-07)	4.1e-36 (1.99e-33)	0.683 (1.00)	0.000368 (0.126)
Del Peak 10(4q34 3)	86 (20%)	336	0.0509 (1.00)	0.000128 (0.0464)	1.32e-24 (6.35e-22)	0.363 (1.00)	7.21e-05 (0.0264)
Del Peak 17(8p21 2)	77 (18%)	345	0.625 (1.00)	4.23e-05 (0.0157)	1.43e-32 (6.91e-30)	0.683 (1.00)	0.00011 (0.0403)
Del Peak 36(16q23 1)	118 (28%)	304	0.101 (1.00)	3.3e-08 (1.35e-05)	2.23e-24 (1.07e-21)	0.414 (1.00)	0.000255 (0.0894)
Del Peak 42(19p13 3)	106 (25%)	316	0.0078 (1.00)	1.27e-13 (5.67e-11)	1.64e-41 (7.97e-39)	0.275 (1.00)	0.000633 (0.214)
Amp Peak 1(1p35 2)	39 (9%)	383	0.606 (1.00)	0.000205 (0.0732)	7.19e-11 (3.08e-08)	1 (1.00)	0.0494 (1.00)
Amp Peak 5(1q22)	194 (46%)	228	0.0536 (1.00)	1.92e-06 (0.000751)	0.000435 (0.148)	0.527 (1.00)	0.91 (1.00)
Amp Peak 8(2q13)	86 (20%)	336	0.0129 (1.00)	0.000352 (0.121)	1.76e-13 (7.86e-11)	0.697 (1.00)	0.068 (1.00)
Amp Peak 9(3p25 1)	59 (14%)	363	0.349 (1.00)	0.000292 (0.102)	9.18e-09 (3.8e-06)	0.129 (1.00)	0.628 (1.00)
Amp Peak 10(3q26 2)	123 (29%)	299	0.224 (1.00)	2.43e-09 (1.02e-06)	1.11e-22 (5.28e-20)	0.166 (1.00)	0.00114 (0.385)
Amp Peak 11(4p16 3)	38 (9%)	384	0.901 (1.00)	1.44e-06 (0.000566)	8.13e-16 (3.72e-13)	0.714 (1.00)	0.0311 (1.00)
Amp Peak 13(6p24 2)	79 (19%)	343	0.916 (1.00)	7.02e-06 (0.0027)	5.73e-17 (2.64e-14)	0.28 (1.00)	0.113 (1.00)
Amp Peak 16(8p11 21)	122 (29%)	300	4.34e-05 (0.016)	0.354 (1.00)	1.3e-06 (0.00051)	0.0482 (1.00)	0.262 (1.00)
Amp Peak 20(9q34 3)	31 (7%)	391	0.0758 (1.00)	0.000394 (0.134)	1.83e-06 (0.000718)	0.843 (1.00)	0.192 (1.00)
Amp Peak 22(11p11 2)	36 (9%)	386	0.033 (1.00)	0.00017 (0.0612)	8.62e-08 (3.47e-05)	0.458 (1.00)	0.419 (1.00)
Amp Peak 28(13q34)	40 (9%)	382	0.677 (1.00)	4.54e-07 (0.000181)	7.07e-11 (3.04e-08)	1 (1.00)	0.248 (1.00)
Amp Peak 29(14q24 3)	46 (11%)	376	0.477 (1.00)	1.54e-05 (0.00584)	5.6e-10 (2.38e-07)	0.178 (1.00)	0.0101 (1.00)
Amp Peak 30(14q32 33)	56 (13%)	366	0.167 (1.00)	0.000239 (0.0842)	2.18e-08 (9.01e-06)	0.12 (1.00)	0.0201 (1.00)
Amp Peak 34(17q11 2)	52 (12%)	370	0.0527 (1.00)	0.000231 (0.0817)	2.61e-14 (1.18e-11)	0.527 (1.00)	0.0396 (1.00)
Amp Peak 35(17q12)	51 (12%)	371	0.0602 (1.00)	0.000128 (0.0464)	8.78e-18 (4.06e-15)	0.747 (1.00)	0.00532 (1.00)
Amp Peak 36(17q21 32)	46 (11%)	376	0.0521 (1.00)	3.63e-06 (0.0014)	1.06e-09 (4.47e-07)	0.866 (1.00)	0.0468 (1.00)
Amp Peak 37(17q25 3)	62 (15%)	360	0.116 (1.00)	0.000316 (0.109)	5.59e-13 (2.49e-10)	0.656 (1.00)	0.00123 (0.413)
Amp Peak 39(19p13 2)	66 (16%)	356	0.936 (1.00)	4.32e-11 (1.86e-08)	2.02e-18 (9.38e-16)	0.246 (1.00)	0.641 (1.00)
Amp Peak 40(19p13 11)	64 (15%)	358	0.547 (1.00)	1.38e-09 (5.82e-07)	6.91e-20 (3.25e-17)	0.305 (1.00)	0.115 (1.00)
Amp Peak 42(20p13)	81 (19%)	341	0.156 (1.00)	3.18e-05 (0.0119)	4.74e-12 (2.08e-09)	0.184 (1.00)	0.00611 (1.00)
Amp Peak 43(20q11 21)	99 (23%)	323	0.0736 (1.00)	1.3e-07 (5.24e-05)	2.5e-24 (1.2e-21)	0.0626 (1.00)	0.0159 (1.00)
Amp Peak 44(20q13 33)	107 (25%)	315	0.369 (1.00)	3.75e-08 (1.53e-05)	7.48e-20 (3.51e-17)	0.00355 (1.00)	0.0278 (1.00)
Del Peak 1(1p36 21)	51 (12%)	371	0.393 (1.00)	0.000142 (0.051)	4.71e-08 (1.91e-05)	0.52 (1.00)	0.0364 (1.00)
Del Peak 2(1p36 11)	55 (13%)	367	0.3 (1.00)	0.000254 (0.0892)	6.99e-11 (3.01e-08)	0.876 (1.00)	0.0919 (1.00)
Del Peak 5(2q22 1)	33 (8%)	389	2.21e-07 (8.86e-05)	0.0129 (1.00)	4.07e-05 (0.0151)	0.0172 (1.00)	1 (1.00)
Del Peak 7(3p14 2)	55 (13%)	367	0.776 (1.00)	1.09e-05 (0.00414)	9.03e-14 (4.05e-11)	0.435 (1.00)	0.178 (1.00)
Del Peak 8(4p16 3)	59 (14%)	363	0.256 (1.00)	0.000618 (0.209)	4.5e-12 (1.98e-09)	0.546 (1.00)	0.0218 (1.00)
Del Peak 9(4q22 1)	71 (17%)	351	0.0179 (1.00)	7.04e-05 (0.0258)	3.38e-24 (1.61e-21)	0.205 (1.00)	0.00239 (0.777)
Del Peak 11(5q11 2)	69 (16%)	353	0.122 (1.00)	2.26e-05 (0.00849)	1.5e-22 (7.15e-20)	0.777 (1.00)	0.0461 (1.00)
Del Peak 13(7p22 3)	53 (13%)	369	0.0343 (1.00)	1.98e-05 (0.00747)	1.64e-12 (7.27e-10)	0.751 (1.00)	0.0257 (1.00)
Del Peak 14(7q31 1)	38 (9%)	384	0.706 (1.00)	3.41e-06 (0.00132)	5.93e-17 (2.72e-14)	0.714 (1.00)	0.00136 (0.453)
Del Peak 15(7q36 3)	48 (11%)	374	0.566 (1.00)	4.26e-08 (1.73e-05)	1.22e-16 (5.58e-14)	1 (1.00)	0.0194 (1.00)
Del Peak 18(9p23)	46 (11%)	376	0.372 (1.00)	0.000267 (0.0931)	1.48e-10 (6.33e-08)	0.313 (1.00)	0.205 (1.00)
Del Peak 19(9q21 2)	88 (21%)	334	0.0765 (1.00)	7.01e-12 (3.07e-09)	1.7e-19 (7.95e-17)	0.301 (1.00)	0.0259 (1.00)
Del Peak 20(9q34 11)	95 (23%)	327	0.486 (1.00)	7.7e-10 (3.26e-07)	4.02e-18 (1.86e-15)	0.314 (1.00)	0.0144 (1.00)
Del Peak 24(11p15 5)	72 (17%)	350	0.0234 (1.00)	6.95e-08 (2.81e-05)	2.42e-21 (1.15e-18)	0.162 (1.00)	0.0163 (1.00)
Del Peak 25(11q14 1)	48 (11%)	374	0.0485 (1.00)	9.6e-06 (0.00368)	3.2e-12 (1.42e-09)	0.62 (1.00)	0.0194 (1.00)
Del Peak 26(11q25)	67 (16%)	355	0.00287 (0.927)	0.000124 (0.0452)	1.06e-13 (4.74e-11)	0.0302 (1.00)	0.0625 (1.00)
Del Peak 28(12q24 33)	40 (9%)	382	0.0741 (1.00)	0.000221 (0.079)	1.55e-11 (6.74e-09)	0.15 (1.00)	0.032 (1.00)
Del Peak 31(15q15 1)	95 (23%)	327	0.0613 (1.00)	3.84e-09 (1.6e-06)	8.3e-20 (3.89e-17)	0.0603 (1.00)	0.0144 (1.00)
Del Peak 32(15q23)	76 (18%)	346	0.0484 (1.00)	1.28e-06 (0.000505)	5.29e-19 (2.47e-16)	0.221 (1.00)	0.0395 (1.00)
Del Peak 33(16p13 3)	59 (14%)	363	0.0286 (1.00)	2.86e-08 (1.17e-05)	2.3e-15 (1.05e-12)	0.364 (1.00)	0.419 (1.00)
Del Peak 34(16q21)	108 (26%)	314	0.0865 (1.00)	2.92e-09 (1.22e-06)	7.21e-21 (3.4e-18)	0.335 (1.00)	0.00432 (1.00)
Del Peak 35(16q22 3)	113 (27%)	309	0.14 (1.00)	6.5e-09 (2.7e-06)	1.53e-21 (7.26e-19)	0.479 (1.00)	0.011 (1.00)
Del Peak 37(17p13 3)	77 (18%)	345	0.209 (1.00)	3.37e-06 (0.00131)	2.13e-18 (9.89e-16)	0.341 (1.00)	0.00201 (0.662)
Del Peak 38(17p11 2)	83 (20%)	339	0.0862 (1.00)	2.56e-08 (1.06e-05)	4.36e-26 (2.1e-23)	0.356 (1.00)	0.00166 (0.551)
Del Peak 39(17q11 2)	70 (17%)	352	0.835 (1.00)	6.43e-07 (0.000256)	9.65e-12 (4.22e-09)	0.205 (1.00)	0.172 (1.00)
Del Peak 40(17q21 31)	67 (16%)	355	0.603 (1.00)	5.17e-06 (0.00199)	7.52e-11 (3.22e-08)	0.315 (1.00)	0.0625 (1.00)
Del Peak 41(18q23)	68 (16%)	354	0.0284 (1.00)	0.000312 (0.108)	7.37e-15 (3.34e-12)	0.00393 (1.00)	0.539 (1.00)
Del Peak 44(19q13 43)	44 (10%)	378	0.00119 (0.399)	1.89e-05 (0.00713)	4.86e-15 (2.21e-12)	0.865 (1.00)	0.0149 (1.00)
Del Peak 49(22q13 31)	92 (22%)	330	0.0329 (1.00)	5.46e-08 (2.21e-05)	4.24e-17 (1.95e-14)	0.308 (1.00)	0.0284 (1.00)
Del Peak 50(Xp21 1)	60 (14%)	362	0.0032 (1.00)	5.64e-05 (0.0208)	6.55e-13 (2.91e-10)	0.456 (1.00)	0.518 (1.00)
Amp Peak 2(1p34 3)	42 (10%)	380	0.432 (1.00)	0.00314 (1.00)	8.72e-15 (3.94e-12)	0.379 (1.00)	0.0388 (1.00)
Amp Peak 4(1q21 3)	182 (43%)	240	0.265 (1.00)	4.2e-05 (0.0156)	0.00398 (1.00)	0.671 (1.00)	0.21 (1.00)
Amp Peak 7(2p23 2)	92 (22%)	330	0.00482 (1.00)	0.00354 (1.00)	5.23e-10 (2.23e-07)	0.0306 (1.00)	0.274 (1.00)
Amp Peak 12(5p15 33)	61 (14%)	361	0.0447 (1.00)	0.00159 (0.531)	2.68e-15 (1.22e-12)	0.654 (1.00)	0.203 (1.00)
Amp Peak 14(6q25 1)	59 (14%)	363	0.535 (1.00)	0.0428 (1.00)	0.000351 (0.121)	0.763 (1.00)	0.419 (1.00)
Amp Peak 15(7q32 2)	57 (14%)	365	3.98e-05 (0.0148)	0.313 (1.00)	0.152 (1.00)	0.0451 (1.00)	0.869 (1.00)
Amp Peak 17(8q24 21)	148 (35%)	274	0.0021 (0.684)	0.455 (1.00)	4.11e-11 (1.78e-08)	0.098 (1.00)	0.00199 (0.66)
Amp Peak 18(8q24 21)	157 (37%)	265	0.0105 (1.00)	0.249 (1.00)	1.04e-11 (4.52e-09)	0.0222 (1.00)	0.0101 (1.00)
Amp Peak 19(9p24 2)	46 (11%)	376	0.908 (1.00)	0.0121 (1.00)	6.8e-07 (0.00027)	0.178 (1.00)	0.0468 (1.00)
Amp Peak 23(11q13 2)	53 (13%)	369	0.204 (1.00)	0.00349 (1.00)	1.01e-06 (0.000401)	1 (1.00)	0.0594 (1.00)
Amp Peak 25(12p12 1)	65 (15%)	357	0.706 (1.00)	0.579 (1.00)	3.93e-06 (0.00152)	0.385 (1.00)	1 (1.00)
Amp Peak 26(12q13 11)	65 (15%)	357	0.827 (1.00)	0.803 (1.00)	2.94e-06 (0.00114)	0.147 (1.00)	0.639 (1.00)
Amp Peak 27(12q13 2)	68 (16%)	354	0.814 (1.00)	0.164 (1.00)	1.05e-05 (0.00402)	0.0872 (1.00)	0.759 (1.00)
Amp Peak 33(17p13 3)	31 (7%)	391	0.467 (1.00)	0.0213 (1.00)	2.3e-09 (9.66e-07)	0.843 (1.00)	0.00904 (1.00)
Amp Peak 38(18q11 2)	47 (11%)	375	0.111 (1.00)	0.018 (1.00)	1.98e-11 (8.58e-09)	0.738 (1.00)	1 (1.00)
Amp Peak 45(22q12 2)	41 (10%)	381	0.593 (1.00)	0.00299 (0.962)	4.27e-19 (2e-16)	0.216 (1.00)	0.259 (1.00)
Del Peak 6(2q37 3)	34 (8%)	388	0.874 (1.00)	0.000227 (0.0805)	0.027 (1.00)	0.699 (1.00)	0.3 (1.00)
Del Peak 12(6q26)	33 (8%)	389	0.214 (1.00)	0.0162 (1.00)	3.87e-08 (1.58e-05)	0.845 (1.00)	0.408 (1.00)
Del Peak 16(8p23 2)	77 (18%)	345	0.295 (1.00)	0.00204 (0.668)	2.68e-25 (1.29e-22)	0.683 (1.00)	0.00201 (0.662)
Del Peak 21(10p12 31)	27 (6%)	395	0.672 (1.00)	0.165 (1.00)	2.94e-05 (0.011)	0.392 (1.00)	0.0623 (1.00)
Del Peak 23(10q23 31)	50 (12%)	372	0.239 (1.00)	0.0301 (1.00)	0.000221 (0.079)	0.0755 (1.00)	0.382 (1.00)
Del Peak 27(12q23 1)	31 (7%)	391	0.0455 (1.00)	0.00451 (1.00)	2.3e-09 (9.66e-07)	0.687 (1.00)	0.00904 (1.00)
Del Peak 29(13q14 2)	64 (15%)	358	0.0757 (1.00)	0.00207 (0.677)	0.000253 (0.0889)	0.187 (1.00)	0.753 (1.00)
Del Peak 30(14q13 1)	51 (12%)	371	0.00386 (1.00)	0.00505 (1.00)	3.66e-12 (1.61e-09)	0.63 (1.00)	0.0816 (1.00)
Del Peak 43(19p12)	34 (8%)	388	0.0907 (1.00)	0.00271 (0.88)	2.4e-07 (9.6e-05)	0.245 (1.00)	0.3 (1.00)
Del Peak 48(22q12 1)	65 (15%)	357	0.374 (1.00)	0.00305 (0.979)	1.05e-05 (0.00402)	0.0808 (1.00)	0.121 (1.00)
Amp Peak 3(1p22 3)	68 (16%)	354	0.938 (1.00)	0.00363 (1.00)	0.0158 (1.00)	0.886 (1.00)	0.284 (1.00)
Amp Peak 6(1q44)	172 (41%)	250	0.306 (1.00)	0.0116 (1.00)	0.219 (1.00)	0.669 (1.00)	0.646 (1.00)
Amp Peak 21(10q22 2)	114 (27%)	308	0.242 (1.00)	0.527 (1.00)	0.233 (1.00)	0.478 (1.00)	0.0977 (1.00)
Amp Peak 24(11q13 3)	41 (10%)	381	0.0952 (1.00)	0.152 (1.00)	0.115 (1.00)	0.379 (1.00)	0.706 (1.00)
Amp Peak 31(15q26 3)	26 (6%)	396	0.837 (1.00)	0.202 (1.00)	0.0119 (1.00)	0.0828 (1.00)	0.102 (1.00)
Amp Peak 46(Xp11 22)	67 (16%)	355	0.272 (1.00)	0.398 (1.00)	0.122 (1.00)	0.113 (1.00)	0.282 (1.00)
Amp Peak 47(Xq28)	71 (17%)	351	0.00842 (1.00)	0.187 (1.00)	0.0277 (1.00)	1 (1.00)	0.652 (1.00)
Del Peak 3(1q43)	7 (2%)	415	0.0262 (1.00)	0.0204 (1.00)	0.745 (1.00)	0.105 (1.00)	1 (1.00)
Del Peak 4(2p25 3)	21 (5%)	401	0.0268 (1.00)	0.136 (1.00)	0.024 (1.00)	0.0964 (1.00)	0.311 (1.00)
Del Peak 22(10q21 1)	27 (6%)	395	0.913 (1.00)	0.0646 (1.00)	0.00704 (1.00)	1 (1.00)	0.821 (1.00)
Del Peak 45(20p12 1)	23 (5%)	399	0.233 (1.00)	0.0562 (1.00)	0.0295 (1.00)	0.651 (1.00)	0.808 (1.00)
Del Peak 46(20q13 12)	10 (2%)	412	0.956 (1.00)	0.533 (1.00)	0.0742 (1.00)	0.0765 (1.00)	0.713 (1.00)
Del Peak 47(22q11 21)	54 (13%)	368	0.75 (1.00)	0.00902 (1.00)	0.0226 (1.00)	0.0399 (1.00)	0.398 (1.00)

'Amp Peak 1(1p35.2) mutation analysis' versus 'AGE'

P value = 0.000205 (t-test), Q value = 0.073

Table S1. Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 1(1P35.2) MUTATED	39	68.7 (8.3)
AMP PEAK 1(1P35.2) WILD-TYPE	382	62.9 (11.2)

Figure S1. Get High-res Image Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 1(1p35.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.19e-11 (Chi-square test), Q value = 3.1e-08

Table S2. Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 1(1P35.2) MUTATED	12	0	0	0	0	4	23
AMP PEAK 1(1P35.2) WILD-TYPE	299	3	8	2	7	13	51

Figure S2. Get High-res Image Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 2(1p34.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.72e-15 (Chi-square test), Q value = 3.9e-12

Table S3. Gene #2: 'Amp Peak 2(1p34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 2(1P34.3) MUTATED	11	0	0	0	0	4	27
AMP PEAK 2(1P34.3) WILD-TYPE	300	3	8	2	7	13	47

Figure S3. Get High-res Image Gene #2: 'Amp Peak 2(1p34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 4(1q21.3) mutation analysis' versus 'AGE'

P value = 4.2e-05 (t-test), Q value = 0.016

Table S4. Gene #4: 'Amp Peak 4(1q21.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 4(1Q21.3) MUTATED	182	65.9 (10.3)
AMP PEAK 4(1Q21.3) WILD-TYPE	239	61.5 (11.3)

Figure S4. Get High-res Image Gene #4: 'Amp Peak 4(1q21.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 5(1q22) mutation analysis' versus 'AGE'

P value = 1.92e-06 (t-test), Q value = 0.00075

Table S5. Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 5(1Q22) MUTATED	194	66.2 (10.3)
AMP PEAK 5(1Q22) WILD-TYPE	227	61.1 (11.3)

Figure S5. Get High-res Image Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 5(1q22) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000435 (Chi-square test), Q value = 0.15

Table S6. Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 5(1Q22) MUTATED	132	0	1	1	2	7	51
AMP PEAK 5(1Q22) WILD-TYPE	179	3	7	1	5	10	23

Figure S6. Get High-res Image Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 7(2p23.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.23e-10 (Chi-square test), Q value = 2.2e-07

Table S7. Gene #7: 'Amp Peak 7(2p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 7(2P23.2) MUTATED	44	0	1	1	1	7	38
AMP PEAK 7(2P23.2) WILD-TYPE	267	3	7	1	6	10	36

Figure S7. Get High-res Image Gene #7: 'Amp Peak 7(2p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 8(2q13) mutation analysis' versus 'AGE'

P value = 0.000352 (t-test), Q value = 0.12

Table S8. Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 8(2Q13) MUTATED	85	66.8 (8.8)
AMP PEAK 8(2Q13) WILD-TYPE	336	62.6 (11.5)

Figure S8. Get High-res Image Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 8(2q13) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.76e-13 (Chi-square test), Q value = 7.9e-11

Table S9. Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 8(2Q13) MUTATED	39	0	1	1	0	4	41
AMP PEAK 8(2Q13) WILD-TYPE	272	3	7	1	7	13	33

Figure S9. Get High-res Image Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 9(3p25.1) mutation analysis' versus 'AGE'

P value = 0.000292 (t-test), Q value = 0.1

Table S10. Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 9(3P25.1) MUTATED	59	68.2 (10.4)
AMP PEAK 9(3P25.1) WILD-TYPE	362	62.6 (11.0)

Figure S10. Get High-res Image Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 9(3p25.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.18e-09 (Chi-square test), Q value = 3.8e-06

Table S11. Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 9(3P25.1) MUTATED	28	0	0	0	1	1	29
AMP PEAK 9(3P25.1) WILD-TYPE	283	3	8	2	6	16	45

Figure S11. Get High-res Image Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 10(3q26.2) mutation analysis' versus 'AGE'

P value = 2.43e-09 (t-test), Q value = 1e-06

Table S12. Gene #10: 'Amp Peak 10(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 10(3Q26.2) MUTATED	123	68.1 (9.4)
AMP PEAK 10(3Q26.2) WILD-TYPE	298	61.5 (11.2)

Figure S12. Get High-res Image Gene #10: 'Amp Peak 10(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 10(3q26.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.11e-22 (Chi-square test), Q value = 5.3e-20

Table S13. Gene #10: 'Amp Peak 10(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 10(3Q26.2) MUTATED	56	0	0	0	2	6	59
AMP PEAK 10(3Q26.2) WILD-TYPE	255	3	8	2	5	11	15

Figure S13. Get High-res Image Gene #10: 'Amp Peak 10(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 11(4p16.3) mutation analysis' versus 'AGE'

P value = 1.44e-06 (t-test), Q value = 0.00057

Table S14. Gene #11: 'Amp Peak 11(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 11(4P16.3) MUTATED	38	70.6 (8.2)
AMP PEAK 11(4P16.3) WILD-TYPE	383	62.7 (11.1)

Figure S14. Get High-res Image Gene #11: 'Amp Peak 11(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 11(4p16.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.13e-16 (Chi-square test), Q value = 3.7e-13

Table S15. Gene #11: 'Amp Peak 11(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 11(4P16.3) MUTATED	10	0	0	0	0	1	27
AMP PEAK 11(4P16.3) WILD-TYPE	301	3	8	2	7	16	47

Figure S15. Get High-res Image Gene #11: 'Amp Peak 11(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 12(5p15.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.68e-15 (Chi-square test), Q value = 1.2e-12

Table S16. Gene #12: 'Amp Peak 12(5p15.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 12(5P15.33) MUTATED	23	0	0	0	0	3	35
AMP PEAK 12(5P15.33) WILD-TYPE	288	3	8	2	7	14	39

Figure S16. Get High-res Image Gene #12: 'Amp Peak 12(5p15.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 13(6p24.2) mutation analysis' versus 'AGE'

P value = 7.02e-06 (t-test), Q value = 0.0027

Table S17. Gene #13: 'Amp Peak 13(6p24.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 13(6P24.2) MUTATED	79	68.2 (9.7)
AMP PEAK 13(6P24.2) WILD-TYPE	342	62.3 (11.1)

Figure S17. Get High-res Image Gene #13: 'Amp Peak 13(6p24.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 13(6p24.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.73e-17 (Chi-square test), Q value = 2.6e-14

Table S18. Gene #13: 'Amp Peak 13(6p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 13(6P24.2) MUTATED	33	0	0	0	0	4	42
AMP PEAK 13(6P24.2) WILD-TYPE	278	3	8	2	7	13	32

Figure S18. Get High-res Image Gene #13: 'Amp Peak 13(6p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 14(6q25.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000351 (Chi-square test), Q value = 0.12

Table S19. Gene #14: 'Amp Peak 14(6q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 14(6Q25.1) MUTATED	32	0	0	0	2	2	23
AMP PEAK 14(6Q25.1) WILD-TYPE	279	3	8	2	5	15	51

Figure S19. Get High-res Image Gene #14: 'Amp Peak 14(6q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 15(7q32.2) mutation analysis' versus 'Time to Death'

P value = 3.98e-05 (logrank test), Q value = 0.015

Table S20. Gene #15: 'Amp Peak 15(7q32.2) mutation analysis' versus Clinical Feature #1: 'Time to Death'

	nPatients	nDeath	Duration Range (Median), Month
ALL	418	40	0.0 - 187.1 (16.6)
AMP PEAK 15(7Q32.2) MUTATED	55	13	0.0 - 113.2 (13.9)
AMP PEAK 15(7Q32.2) WILD-TYPE	363	27	0.1 - 187.1 (16.8)

Figure S20. Get High-res Image Gene #15: 'Amp Peak 15(7q32.2) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Amp Peak 16(8p11.21) mutation analysis' versus 'Time to Death'

P value = 4.34e-05 (logrank test), Q value = 0.016

Table S21. Gene #16: 'Amp Peak 16(8p11.21) mutation analysis' versus Clinical Feature #1: 'Time to Death'

	nPatients	nDeath	Duration Range (Median), Month
ALL	418	40	0.0 - 187.1 (16.6)
AMP PEAK 16(8P11.21) MUTATED	121	21	0.0 - 113.2 (11.9)
AMP PEAK 16(8P11.21) WILD-TYPE	297	19	0.0 - 187.1 (17.5)

Figure S21. Get High-res Image Gene #16: 'Amp Peak 16(8p11.21) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Amp Peak 16(8p11.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.3e-06 (Chi-square test), Q value = 0.00051

Table S22. Gene #16: 'Amp Peak 16(8p11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 16(8P11.21) MUTATED	71	1	0	0	4	5	41
AMP PEAK 16(8P11.21) WILD-TYPE	240	2	8	2	3	12	33

Figure S22. Get High-res Image Gene #16: 'Amp Peak 16(8p11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 17(8q24.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.11e-11 (Chi-square test), Q value = 1.8e-08

Table S23. Gene #17: 'Amp Peak 17(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 17(8Q24.21) MUTATED	83	1	0	0	4	7	53
AMP PEAK 17(8Q24.21) WILD-TYPE	228	2	8	2	3	10	21

Figure S23. Get High-res Image Gene #17: 'Amp Peak 17(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 18(8q24.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.04e-11 (Chi-square test), Q value = 4.5e-09

Table S24. Gene #18: 'Amp Peak 18(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 18(8Q24.21) MUTATED	90	1	0	0	4	6	56
AMP PEAK 18(8Q24.21) WILD-TYPE	221	2	8	2	3	11	18

Figure S24. Get High-res Image Gene #18: 'Amp Peak 18(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 19(9p24.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.8e-07 (Chi-square test), Q value = 0.00027

Table S25. Gene #19: 'Amp Peak 19(9p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 19(9P24.2) MUTATED	20	0	0	0	1	2	23
AMP PEAK 19(9P24.2) WILD-TYPE	291	3	8	2	6	15	51

Figure S25. Get High-res Image Gene #19: 'Amp Peak 19(9p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 20(9q34.3) mutation analysis' versus 'AGE'

P value = 0.000394 (t-test), Q value = 0.13

Table S26. Gene #20: 'Amp Peak 20(9q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 20(9Q34.3) MUTATED	31	69.0 (8.0)
AMP PEAK 20(9Q34.3) WILD-TYPE	390	63.0 (11.2)

Figure S26. Get High-res Image Gene #20: 'Amp Peak 20(9q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 20(9q34.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.83e-06 (Chi-square test), Q value = 0.00072

Table S27. Gene #20: 'Amp Peak 20(9q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 20(9Q34.3) MUTATED	11	0	0	0	0	4	16
AMP PEAK 20(9Q34.3) WILD-TYPE	300	3	8	2	7	13	58

Figure S27. Get High-res Image Gene #20: 'Amp Peak 20(9q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 22(11p11.2) mutation analysis' versus 'AGE'

P value = 0.00017 (t-test), Q value = 0.061

Table S28. Gene #22: 'Amp Peak 22(11p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 22(11P11.2) MUTATED	36	69.8 (9.7)
AMP PEAK 22(11P11.2) WILD-TYPE	385	62.8 (11.1)

Figure S28. Get High-res Image Gene #22: 'Amp Peak 22(11p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 22(11p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.62e-08 (Chi-square test), Q value = 3.5e-05

Table S29. Gene #22: 'Amp Peak 22(11p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 22(11P11.2) MUTATED	13	0	0	0	0	3	20
AMP PEAK 22(11P11.2) WILD-TYPE	298	3	8	2	7	14	54

Figure S29. Get High-res Image Gene #22: 'Amp Peak 22(11p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 23(11q13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.01e-06 (Chi-square test), Q value = 4e-04

Table S30. Gene #23: 'Amp Peak 23(11q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 23(11Q13.2) MUTATED	26	0	0	0	0	2	25
AMP PEAK 23(11Q13.2) WILD-TYPE	285	3	8	2	7	15	49

Figure S30. Get High-res Image Gene #23: 'Amp Peak 23(11q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 25(12p12.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.93e-06 (Chi-square test), Q value = 0.0015

Table S31. Gene #25: 'Amp Peak 25(12p12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 25(12P12.1) MUTATED	33	0	1	0	1	2	28
AMP PEAK 25(12P12.1) WILD-TYPE	278	3	7	2	6	15	46

Figure S31. Get High-res Image Gene #25: 'Amp Peak 25(12p12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 26(12q13.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.94e-06 (Chi-square test), Q value = 0.0011

Table S32. Gene #26: 'Amp Peak 26(12q13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 26(12Q13.11) MUTATED	32	0	1	0	1	3	28
AMP PEAK 26(12Q13.11) WILD-TYPE	279	3	7	2	6	14	46

Figure S32. Get High-res Image Gene #26: 'Amp Peak 26(12q13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 27(12q13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.05e-05 (Chi-square test), Q value = 0.004

Table S33. Gene #27: 'Amp Peak 27(12q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 27(12Q13.2) MUTATED	36	0	1	0	0	3	28
AMP PEAK 27(12Q13.2) WILD-TYPE	275	3	7	2	7	14	46

Figure S33. Get High-res Image Gene #27: 'Amp Peak 27(12q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 28(13q34) mutation analysis' versus 'AGE'

P value = 4.54e-07 (t-test), Q value = 0.00018

Table S34. Gene #28: 'Amp Peak 28(13q34) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 28(13Q34) MUTATED	40	69.9 (7.1)
AMP PEAK 28(13Q34) WILD-TYPE	381	62.8 (11.2)

Figure S34. Get High-res Image Gene #28: 'Amp Peak 28(13q34) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 28(13q34) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.07e-11 (Chi-square test), Q value = 3e-08

Table S35. Gene #28: 'Amp Peak 28(13q34) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 28(13Q34) MUTATED	13	0	0	0	0	3	24
AMP PEAK 28(13Q34) WILD-TYPE	298	3	8	2	7	14	50

Figure S35. Get High-res Image Gene #28: 'Amp Peak 28(13q34) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 29(14q24.3) mutation analysis' versus 'AGE'

P value = 1.54e-05 (t-test), Q value = 0.0058

Table S36. Gene #29: 'Amp Peak 29(14q24.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 29(14Q24.3) MUTATED	46	69.1 (8.4)
AMP PEAK 29(14Q24.3) WILD-TYPE	375	62.7 (11.2)

Figure S36. Get High-res Image Gene #29: 'Amp Peak 29(14q24.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 29(14q24.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.6e-10 (Chi-square test), Q value = 2.4e-07

Table S37. Gene #29: 'Amp Peak 29(14q24.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 29(14Q24.3) MUTATED	17	0	0	0	0	4	25
AMP PEAK 29(14Q24.3) WILD-TYPE	294	3	8	2	7	13	49

Figure S37. Get High-res Image Gene #29: 'Amp Peak 29(14q24.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 30(14q32.33) mutation analysis' versus 'AGE'

P value = 0.000239 (t-test), Q value = 0.084

Table S38. Gene #30: 'Amp Peak 30(14q32.33) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 30(14Q32.33) MUTATED	56	68.1 (9.4)
AMP PEAK 30(14Q32.33) WILD-TYPE	365	62.7 (11.2)

Figure S38. Get High-res Image Gene #30: 'Amp Peak 30(14q32.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 30(14q32.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.18e-08 (Chi-square test), Q value = 9e-06

Table S39. Gene #30: 'Amp Peak 30(14q32.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 30(14Q32.33) MUTATED	25	0	0	0	0	4	27
AMP PEAK 30(14Q32.33) WILD-TYPE	286	3	8	2	7	13	47

Figure S39. Get High-res Image Gene #30: 'Amp Peak 30(14q32.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 32(16p11.2) mutation analysis' versus 'AGE'

P value = 0.00039 (t-test), Q value = 0.13

Table S40. Gene #32: 'Amp Peak 32(16p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 32(16P11.2) MUTATED	44	68.0 (8.3)
AMP PEAK 32(16P11.2) WILD-TYPE	377	62.9 (11.3)

Figure S40. Get High-res Image Gene #32: 'Amp Peak 32(16p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 32(16p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.5e-14 (Chi-square test), Q value = 3.4e-11

Table S41. Gene #32: 'Amp Peak 32(16p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 32(16P11.2) MUTATED	14	0	0	0	0	2	28
AMP PEAK 32(16P11.2) WILD-TYPE	297	3	8	2	7	15	46

Figure S41. Get High-res Image Gene #32: 'Amp Peak 32(16p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 32(16p11.2) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.000134 (Fisher's exact test), Q value = 0.048

Table S42. Gene #32: 'Amp Peak 32(16p11.2) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients	NO	YES
ALL	318	104
AMP PEAK 32(16P11.2) MUTATED	22	22
AMP PEAK 32(16P11.2) WILD-TYPE	296	82

Figure S42. Get High-res Image Gene #32: 'Amp Peak 32(16p11.2) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Amp Peak 33(17p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.3e-09 (Chi-square test), Q value = 9.7e-07

Table S43. Gene #33: 'Amp Peak 33(17p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 33(17P13.3) MUTATED	10	0	0	0	0	1	20
AMP PEAK 33(17P13.3) WILD-TYPE	301	3	8	2	7	16	54

Figure S43. Get High-res Image Gene #33: 'Amp Peak 33(17p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 34(17q11.2) mutation analysis' versus 'AGE'

P value = 0.000231 (t-test), Q value = 0.082

Table S44. Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 34(17Q11.2) MUTATED	52	67.7 (8.1)
AMP PEAK 34(17Q11.2) WILD-TYPE	369	62.8 (11.4)

Figure S44. Get High-res Image Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 34(17q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.61e-14 (Chi-square test), Q value = 1.2e-11

Table S45. Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 34(17Q11.2) MUTATED	16	0	0	0	1	5	30
AMP PEAK 34(17Q11.2) WILD-TYPE	295	3	8	2	6	12	44

Figure S45. Get High-res Image Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 35(17q12) mutation analysis' versus 'AGE'

P value = 0.000128 (t-test), Q value = 0.046

Table S46. Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 35(17Q12) MUTATED	51	68.4 (9.1)
AMP PEAK 35(17Q12) WILD-TYPE	370	62.7 (11.2)

Figure S46. Get High-res Image Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 35(17q12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.78e-18 (Chi-square test), Q value = 4.1e-15

Table S47. Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 35(17Q12) MUTATED	14	0	1	0	0	3	33
AMP PEAK 35(17Q12) WILD-TYPE	297	3	7	2	7	14	41

Figure S47. Get High-res Image Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 36(17q21.32) mutation analysis' versus 'AGE'

P value = 3.63e-06 (t-test), Q value = 0.0014

Table S48. Gene #36: 'Amp Peak 36(17q21.32) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 36(17Q21.32) MUTATED	46	69.4 (8.1)
AMP PEAK 36(17Q21.32) WILD-TYPE	375	62.7 (11.2)

Figure S48. Get High-res Image Gene #36: 'Amp Peak 36(17q21.32) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 36(17q21.32) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.06e-09 (Chi-square test), Q value = 4.5e-07

Table S49. Gene #36: 'Amp Peak 36(17q21.32) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 36(17Q21.32) MUTATED	17	0	0	0	0	5	24
AMP PEAK 36(17Q21.32) WILD-TYPE	294	3	8	2	7	12	50

Figure S49. Get High-res Image Gene #36: 'Amp Peak 36(17q21.32) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 37(17q25.3) mutation analysis' versus 'AGE'

P value = 0.000316 (t-test), Q value = 0.11

Table S50. Gene #37: 'Amp Peak 37(17q25.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 37(17Q25.3) MUTATED	62	67.4 (8.6)
AMP PEAK 37(17Q25.3) WILD-TYPE	359	62.7 (11.3)

Figure S50. Get High-res Image Gene #37: 'Amp Peak 37(17q25.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 37(17q25.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.59e-13 (Chi-square test), Q value = 2.5e-10

Table S51. Gene #37: 'Amp Peak 37(17q25.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 37(17Q25.3) MUTATED	23	0	0	0	1	6	32
AMP PEAK 37(17Q25.3) WILD-TYPE	288	3	8	2	6	11	42

Figure S51. Get High-res Image Gene #37: 'Amp Peak 37(17q25.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 38(18q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.98e-11 (Chi-square test), Q value = 8.6e-09

Table S52. Gene #38: 'Amp Peak 38(18q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 38(18Q11.2) MUTATED	16	0	0	0	1	3	27
AMP PEAK 38(18Q11.2) WILD-TYPE	295	3	8	2	6	14	47

Figure S52. Get High-res Image Gene #38: 'Amp Peak 38(18q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 39(19p13.2) mutation analysis' versus 'AGE'

P value = 4.32e-11 (t-test), Q value = 1.9e-08

Table S53. Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 39(19P13.2) MUTATED	66	70.7 (8.3)
AMP PEAK 39(19P13.2) WILD-TYPE	355	62.1 (11.0)

Figure S53. Get High-res Image Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 39(19p13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.02e-18 (Chi-square test), Q value = 9.4e-16

Table S54. Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 39(19P13.2) MUTATED	21	0	0	0	1	7	37
AMP PEAK 39(19P13.2) WILD-TYPE	290	3	8	2	6	10	37

Figure S54. Get High-res Image Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 40(19p13.11) mutation analysis' versus 'AGE'

P value = 1.38e-09 (t-test), Q value = 5.8e-07

Table S55. Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 40(19P13.11) MUTATED	64	70.2 (8.3)
AMP PEAK 40(19P13.11) WILD-TYPE	357	62.2 (11.1)

Figure S55. Get High-res Image Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 40(19p13.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.91e-20 (Chi-square test), Q value = 3.3e-17

Table S56. Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 40(19P13.11) MUTATED	20	0	0	0	0	6	38
AMP PEAK 40(19P13.11) WILD-TYPE	291	3	8	2	7	11	36

Figure S56. Get High-res Image Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 41(19q12) mutation analysis' versus 'AGE'

P value = 1.7e-09 (t-test), Q value = 7.2e-07

Table S57. Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 41(19Q12) MUTATED	77	69.0 (7.7)
AMP PEAK 41(19Q12) WILD-TYPE	344	62.2 (11.4)

Figure S57. Get High-res Image Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 41(19q12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.1e-36 (Chi-square test), Q value = 2e-33

Table S58. Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 41(19Q12) MUTATED	17	0	0	0	0	9	51
AMP PEAK 41(19Q12) WILD-TYPE	294	3	8	2	7	8	23

Figure S58. Get High-res Image Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 41(19q12) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.000368 (Fisher's exact test), Q value = 0.13

Table S59. Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients	NO	YES
ALL	318	104
AMP PEAK 41(19Q12) MUTATED	45	32
AMP PEAK 41(19Q12) WILD-TYPE	273	72

Figure S59. Get High-res Image Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Amp Peak 42(20p13) mutation analysis' versus 'AGE'

P value = 3.18e-05 (t-test), Q value = 0.012

Table S60. Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 42(20P13) MUTATED	81	68.0 (10.5)
AMP PEAK 42(20P13) WILD-TYPE	340	62.3 (11.0)

Figure S60. Get High-res Image Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 42(20p13) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.74e-12 (Chi-square test), Q value = 2.1e-09

Table S61. Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 42(20P13) MUTATED	38	0	0	1	0	4	38
AMP PEAK 42(20P13) WILD-TYPE	273	3	8	1	7	13	36

Figure S61. Get High-res Image Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 43(20q11.21) mutation analysis' versus 'AGE'

P value = 1.3e-07 (t-test), Q value = 5.2e-05

Table S62. Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 43(20Q11.21) MUTATED	99	68.1 (9.1)
AMP PEAK 43(20Q11.21) WILD-TYPE	322	62.0 (11.3)

Figure S62. Get High-res Image Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 43(20q11.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.5e-24 (Chi-square test), Q value = 1.2e-21

Table S63. Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 43(20Q11.21) MUTATED	39	0	0	1	0	6	53
AMP PEAK 43(20Q11.21) WILD-TYPE	272	3	8	1	7	11	21

Figure S63. Get High-res Image Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 44(20q13.33) mutation analysis' versus 'AGE'

P value = 3.75e-08 (t-test), Q value = 1.5e-05

Table S64. Gene #44: 'Amp Peak 44(20q13.33) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
AMP PEAK 44(20Q13.33) MUTATED	107	68.2 (9.7)
AMP PEAK 44(20Q13.33) WILD-TYPE	314	61.8 (11.1)

Figure S64. Get High-res Image Gene #44: 'Amp Peak 44(20q13.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 44(20q13.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.48e-20 (Chi-square test), Q value = 3.5e-17

Table S65. Gene #44: 'Amp Peak 44(20q13.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 44(20Q13.33) MUTATED	46	0	0	1	2	6	52
AMP PEAK 44(20Q13.33) WILD-TYPE	265	3	8	1	5	11	22

Figure S65. Get High-res Image Gene #44: 'Amp Peak 44(20q13.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 45(22q12.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.27e-19 (Chi-square test), Q value = 2e-16

Table S66. Gene #45: 'Amp Peak 45(22q12.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
AMP PEAK 45(22Q12.2) MUTATED	9	0	0	0	0	2	30
AMP PEAK 45(22Q12.2) WILD-TYPE	302	3	8	2	7	15	44

Figure S66. Get High-res Image Gene #45: 'Amp Peak 45(22q12.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 1(1p36.21) mutation analysis' versus 'AGE'

P value = 0.000142 (t-test), Q value = 0.051

Table S67. Gene #48: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 1(1P36.21) MUTATED	51	68.8 (9.9)
DEL PEAK 1(1P36.21) WILD-TYPE	370	62.7 (11.1)

Figure S67. Get High-res Image Gene #48: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 1(1p36.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.71e-08 (Chi-square test), Q value = 1.9e-05

Table S68. Gene #48: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 1(1P36.21) MUTATED	22	0	0	0	0	4	25
DEL PEAK 1(1P36.21) WILD-TYPE	289	3	8	2	7	13	49

Figure S68. Get High-res Image Gene #48: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 2(1p36.11) mutation analysis' versus 'AGE'

P value = 0.000254 (t-test), Q value = 0.089

Table S69. Gene #49: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 2(1P36.11) MUTATED	55	68.0 (9.3)
DEL PEAK 2(1P36.11) WILD-TYPE	366	62.7 (11.2)

Figure S69. Get High-res Image Gene #49: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 2(1p36.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.99e-11 (Chi-square test), Q value = 3e-08

Table S70. Gene #49: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 2(1P36.11) MUTATED	22	0	0	0	0	4	29
DEL PEAK 2(1P36.11) WILD-TYPE	289	3	8	2	7	13	45

Figure S70. Get High-res Image Gene #49: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 5(2q22.1) mutation analysis' versus 'Time to Death'

P value = 2.21e-07 (logrank test), Q value = 8.9e-05

Table S71. Gene #52: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

	nPatients	nDeath	Duration Range (Median), Month
ALL	418	40	0.0 - 187.1 (16.6)
DEL PEAK 5(2Q22.1) MUTATED	33	9	0.1 - 113.2 (7.9)
DEL PEAK 5(2Q22.1) WILD-TYPE	385	31	0.0 - 187.1 (17.5)

Figure S71. Get High-res Image Gene #52: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Del Peak 5(2q22.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.07e-05 (Chi-square test), Q value = 0.015

Table S72. Gene #52: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 5(2Q22.1) MUTATED	14	0	0	0	1	1	17
DEL PEAK 5(2Q22.1) WILD-TYPE	297	3	8	2	6	16	57

Figure S72. Get High-res Image Gene #52: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 6(2q37.3) mutation analysis' versus 'AGE'

P value = 0.000227 (t-test), Q value = 0.08

Table S73. Gene #53: 'Del Peak 6(2q37.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 6(2Q37.3) MUTATED	34	68.1 (6.8)
DEL PEAK 6(2Q37.3) WILD-TYPE	387	63.0 (11.3)

Figure S73. Get High-res Image Gene #53: 'Del Peak 6(2q37.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 7(3p14.2) mutation analysis' versus 'AGE'

P value = 1.09e-05 (t-test), Q value = 0.0041

Table S74. Gene #54: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 7(3P14.2) MUTATED	55	67.9 (7.1)
DEL PEAK 7(3P14.2) WILD-TYPE	366	62.7 (11.4)

Figure S74. Get High-res Image Gene #54: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 7(3p14.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.03e-14 (Chi-square test), Q value = 4.1e-11

Table S75. Gene #54: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 7(3P14.2) MUTATED	18	0	0	0	1	6	30
DEL PEAK 7(3P14.2) WILD-TYPE	293	3	8	2	6	11	44

Figure S75. Get High-res Image Gene #54: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 8(4p16.3) mutation analysis' versus 'AGE'

P value = 0.000618 (t-test), Q value = 0.21

Table S76. Gene #55: 'Del Peak 8(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 8(4P16.3) MUTATED	59	67.3 (8.5)
DEL PEAK 8(4P16.3) WILD-TYPE	362	62.8 (11.4)

Figure S76. Get High-res Image Gene #55: 'Del Peak 8(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 8(4p16.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.5e-12 (Chi-square test), Q value = 2e-09

Table S77. Gene #55: 'Del Peak 8(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 8(4P16.3) MUTATED	22	0	0	0	2	4	31
DEL PEAK 8(4P16.3) WILD-TYPE	289	3	8	2	5	13	43

Figure S77. Get High-res Image Gene #55: 'Del Peak 8(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 9(4q22.1) mutation analysis' versus 'AGE'

P value = 7.04e-05 (t-test), Q value = 0.026

Table S78. Gene #56: 'Del Peak 9(4q22.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 9(4Q22.1) MUTATED	71	67.5 (8.7)
DEL PEAK 9(4Q22.1) WILD-TYPE	350	62.6 (11.4)

Figure S78. Get High-res Image Gene #56: 'Del Peak 9(4q22.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 9(4q22.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.38e-24 (Chi-square test), Q value = 1.6e-21

Table S79. Gene #56: 'Del Peak 9(4q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 9(4Q22.1) MUTATED	21	0	0	0	1	5	44
DEL PEAK 9(4Q22.1) WILD-TYPE	290	3	8	2	6	12	30

Figure S79. Get High-res Image Gene #56: 'Del Peak 9(4q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 10(4q34.3) mutation analysis' versus 'AGE'

P value = 0.000128 (t-test), Q value = 0.046

Table S80. Gene #57: 'Del Peak 10(4q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 10(4Q34.3) MUTATED	86	67.2 (9.5)
DEL PEAK 10(4Q34.3) WILD-TYPE	335	62.5 (11.3)

Figure S80. Get High-res Image Gene #57: 'Del Peak 10(4q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 10(4q34.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.32e-24 (Chi-square test), Q value = 6.4e-22

Table S81. Gene #57: 'Del Peak 10(4q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 10(4Q34.3) MUTATED	29	0	0	0	2	6	49
DEL PEAK 10(4Q34.3) WILD-TYPE	282	3	8	2	5	11	25

Figure S81. Get High-res Image Gene #57: 'Del Peak 10(4q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 10(4q34.3) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 7.21e-05 (Fisher's exact test), Q value = 0.026

Table S82. Gene #57: 'Del Peak 10(4q34.3) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients	NO	YES
ALL	318	104
DEL PEAK 10(4Q34.3) MUTATED	50	36
DEL PEAK 10(4Q34.3) WILD-TYPE	268	68

Figure S82. Get High-res Image Gene #57: 'Del Peak 10(4q34.3) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Del Peak 11(5q11.2) mutation analysis' versus 'AGE'

P value = 2.26e-05 (t-test), Q value = 0.0085

Table S83. Gene #58: 'Del Peak 11(5q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 11(5Q11.2) MUTATED	69	67.8 (8.5)
DEL PEAK 11(5Q11.2) WILD-TYPE	352	62.6 (11.4)

Figure S83. Get High-res Image Gene #58: 'Del Peak 11(5q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 11(5q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.5e-22 (Chi-square test), Q value = 7.1e-20

Table S84. Gene #58: 'Del Peak 11(5q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 11(5Q11.2) MUTATED	23	0	0	0	1	2	43
DEL PEAK 11(5Q11.2) WILD-TYPE	288	3	8	2	6	15	31

Figure S84. Get High-res Image Gene #58: 'Del Peak 11(5q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 12(6q26) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.87e-08 (Chi-square test), Q value = 1.6e-05

Table S85. Gene #59: 'Del Peak 12(6q26) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 12(6Q26) MUTATED	10	0	1	0	0	3	19
DEL PEAK 12(6Q26) WILD-TYPE	301	3	7	2	7	14	55

Figure S85. Get High-res Image Gene #59: 'Del Peak 12(6q26) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 13(7p22.3) mutation analysis' versus 'AGE'

P value = 1.98e-05 (t-test), Q value = 0.0075

Table S86. Gene #60: 'Del Peak 13(7p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 13(7P22.3) MUTATED	52	69.1 (9.3)
DEL PEAK 13(7P22.3) WILD-TYPE	369	62.6 (11.1)

Figure S86. Get High-res Image Gene #60: 'Del Peak 13(7p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 13(7p22.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.64e-12 (Chi-square test), Q value = 7.3e-10

Table S87. Gene #60: 'Del Peak 13(7p22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 13(7P22.3) MUTATED	18	0	0	0	1	5	29
DEL PEAK 13(7P22.3) WILD-TYPE	293	3	8	2	6	12	45

Figure S87. Get High-res Image Gene #60: 'Del Peak 13(7p22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 14(7q31.1) mutation analysis' versus 'AGE'

P value = 3.41e-06 (t-test), Q value = 0.0013

Table S88. Gene #61: 'Del Peak 14(7q31.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 14(7Q31.1) MUTATED	38	69.4 (7.0)
DEL PEAK 14(7Q31.1) WILD-TYPE	383	62.8 (11.3)

Figure S88. Get High-res Image Gene #61: 'Del Peak 14(7q31.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 14(7q31.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.93e-17 (Chi-square test), Q value = 2.7e-14

Table S89. Gene #61: 'Del Peak 14(7q31.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 14(7Q31.1) MUTATED	7	0	0	0	1	3	27
DEL PEAK 14(7Q31.1) WILD-TYPE	304	3	8	2	6	14	47

Figure S89. Get High-res Image Gene #61: 'Del Peak 14(7q31.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 15(7q36.3) mutation analysis' versus 'AGE'

P value = 4.26e-08 (t-test), Q value = 1.7e-05

Table S90. Gene #62: 'Del Peak 15(7q36.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 15(7Q36.3) MUTATED	48	70.4 (8.0)
DEL PEAK 15(7Q36.3) WILD-TYPE	373	62.5 (11.1)

Figure S90. Get High-res Image Gene #62: 'Del Peak 15(7q36.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 15(7q36.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.22e-16 (Chi-square test), Q value = 5.6e-14

Table S91. Gene #62: 'Del Peak 15(7q36.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 15(7Q36.3) MUTATED	12	0	0	0	1	5	30
DEL PEAK 15(7Q36.3) WILD-TYPE	299	3	8	2	6	12	44

Figure S91. Get High-res Image Gene #62: 'Del Peak 15(7q36.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 16(8p23.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.68e-25 (Chi-square test), Q value = 1.3e-22

Table S92. Gene #63: 'Del Peak 16(8p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 16(8P23.2) MUTATED	24	0	0	0	2	4	47
DEL PEAK 16(8P23.2) WILD-TYPE	287	3	8	2	5	13	27

Figure S92. Get High-res Image Gene #63: 'Del Peak 16(8p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 17(8p21.2) mutation analysis' versus 'AGE'

P value = 4.23e-05 (t-test), Q value = 0.016

Table S93. Gene #64: 'Del Peak 17(8p21.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 17(8P21.2) MUTATED	77	67.5 (8.9)
DEL PEAK 17(8P21.2) WILD-TYPE	344	62.5 (11.4)

Figure S93. Get High-res Image Gene #64: 'Del Peak 17(8p21.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 17(8p21.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.43e-32 (Chi-square test), Q value = 6.9e-30

Table S94. Gene #64: 'Del Peak 17(8p21.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 17(8P21.2) MUTATED	19	0	0	0	2	5	51
DEL PEAK 17(8P21.2) WILD-TYPE	292	3	8	2	5	12	23

Figure S94. Get High-res Image Gene #64: 'Del Peak 17(8p21.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 17(8p21.2) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.00011 (Fisher's exact test), Q value = 0.04

Table S95. Gene #64: 'Del Peak 17(8p21.2) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients	NO	YES
ALL	318	104
DEL PEAK 17(8P21.2) MUTATED	44	33
DEL PEAK 17(8P21.2) WILD-TYPE	274	71

Figure S95. Get High-res Image Gene #64: 'Del Peak 17(8p21.2) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Del Peak 18(9p23) mutation analysis' versus 'AGE'

P value = 0.000267 (t-test), Q value = 0.093

Table S96. Gene #65: 'Del Peak 18(9p23) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 18(9P23) MUTATED	46	67.9 (7.9)
DEL PEAK 18(9P23) WILD-TYPE	375	62.9 (11.3)

Figure S96. Get High-res Image Gene #65: 'Del Peak 18(9p23) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 18(9p23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.48e-10 (Chi-square test), Q value = 6.3e-08

Table S97. Gene #65: 'Del Peak 18(9p23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 18(9P23) MUTATED	17	0	0	0	0	3	26
DEL PEAK 18(9P23) WILD-TYPE	294	3	8	2	7	14	48

Figure S97. Get High-res Image Gene #65: 'Del Peak 18(9p23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 19(9q21.2) mutation analysis' versus 'AGE'

P value = 7.01e-12 (t-test), Q value = 3.1e-09

Table S98. Gene #66: 'Del Peak 19(9q21.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 19(9Q21.2) MUTATED	88	69.7 (8.3)
DEL PEAK 19(9Q21.2) WILD-TYPE	333	61.8 (11.2)

Figure S98. Get High-res Image Gene #66: 'Del Peak 19(9q21.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 19(9q21.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.7e-19 (Chi-square test), Q value = 7.9e-17

Table S99. Gene #66: 'Del Peak 19(9q21.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 19(9Q21.2) MUTATED	34	0	0	0	1	8	45
DEL PEAK 19(9Q21.2) WILD-TYPE	277	3	8	2	6	9	29

Figure S99. Get High-res Image Gene #66: 'Del Peak 19(9q21.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 20(9q34.11) mutation analysis' versus 'AGE'

P value = 7.7e-10 (t-test), Q value = 3.3e-07

Table S100. Gene #67: 'Del Peak 20(9q34.11) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 20(9Q34.11) MUTATED	95	68.7 (8.4)
DEL PEAK 20(9Q34.11) WILD-TYPE	326	61.9 (11.3)

Figure S100. Get High-res Image Gene #67: 'Del Peak 20(9q34.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 20(9q34.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.02e-18 (Chi-square test), Q value = 1.9e-15

Table S101. Gene #67: 'Del Peak 20(9q34.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 20(9Q34.11) MUTATED	39	0	0	0	2	8	46
DEL PEAK 20(9Q34.11) WILD-TYPE	272	3	8	2	5	9	28

Figure S101. Get High-res Image Gene #67: 'Del Peak 20(9q34.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 21(10p12.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.94e-05 (Chi-square test), Q value = 0.011

Table S102. Gene #68: 'Del Peak 21(10p12.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 21(10P12.31) MUTATED	10	0	0	0	1	1	15
DEL PEAK 21(10P12.31) WILD-TYPE	301	3	8	2	6	16	59

Figure S102. Get High-res Image Gene #68: 'Del Peak 21(10p12.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 23(10q23.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000221 (Chi-square test), Q value = 0.079

Table S103. Gene #70: 'Del Peak 23(10q23.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 23(10Q23.31) MUTATED	25	0	0	0	1	3	21
DEL PEAK 23(10Q23.31) WILD-TYPE	286	3	8	2	6	14	53

Figure S103. Get High-res Image Gene #70: 'Del Peak 23(10q23.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 24(11p15.5) mutation analysis' versus 'AGE'

P value = 6.95e-08 (t-test), Q value = 2.8e-05

Table S104. Gene #71: 'Del Peak 24(11p15.5) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 24(11P15.5) MUTATED	72	68.9 (8.3)
DEL PEAK 24(11P15.5) WILD-TYPE	349	62.3 (11.3)

Figure S104. Get High-res Image Gene #71: 'Del Peak 24(11p15.5) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 24(11p15.5) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.42e-21 (Chi-square test), Q value = 1.1e-18

Table S105. Gene #71: 'Del Peak 24(11p15.5) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 24(11P15.5) MUTATED	23	0	0	0	1	6	42
DEL PEAK 24(11P15.5) WILD-TYPE	288	3	8	2	6	11	32

Figure S105. Get High-res Image Gene #71: 'Del Peak 24(11p15.5) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 25(11q14.1) mutation analysis' versus 'AGE'

P value = 9.6e-06 (t-test), Q value = 0.0037

Table S106. Gene #72: 'Del Peak 25(11q14.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 25(11Q14.1) MUTATED	48	68.9 (8.0)
DEL PEAK 25(11Q14.1) WILD-TYPE	373	62.7 (11.3)

Figure S106. Get High-res Image Gene #72: 'Del Peak 25(11q14.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 25(11q14.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.2e-12 (Chi-square test), Q value = 1.4e-09

Table S107. Gene #72: 'Del Peak 25(11q14.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 25(11Q14.1) MUTATED	16	0	0	0	0	6	26
DEL PEAK 25(11Q14.1) WILD-TYPE	295	3	8	2	7	11	48

Figure S107. Get High-res Image Gene #72: 'Del Peak 25(11q14.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 26(11q25) mutation analysis' versus 'AGE'

P value = 0.000124 (t-test), Q value = 0.045

Table S108. Gene #73: 'Del Peak 26(11q25) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 26(11Q25) MUTATED	67	67.8 (9.6)
DEL PEAK 26(11Q25) WILD-TYPE	354	62.6 (11.2)

Figure S108. Get High-res Image Gene #73: 'Del Peak 26(11q25) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 26(11q25) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.06e-13 (Chi-square test), Q value = 4.7e-11

Table S109. Gene #73: 'Del Peak 26(11q25) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 26(11Q25) MUTATED	27	0	0	0	0	5	35
DEL PEAK 26(11Q25) WILD-TYPE	284	3	8	2	7	12	39

Figure S109. Get High-res Image Gene #73: 'Del Peak 26(11q25) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 27(12q23.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.3e-09 (Chi-square test), Q value = 9.7e-07

Table S110. Gene #74: 'Del Peak 27(12q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 27(12Q23.1) MUTATED	10	0	0	0	0	1	20
DEL PEAK 27(12Q23.1) WILD-TYPE	301	3	8	2	7	16	54

Figure S110. Get High-res Image Gene #74: 'Del Peak 27(12q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 28(12q24.33) mutation analysis' versus 'AGE'

P value = 0.000221 (t-test), Q value = 0.079

Table S111. Gene #75: 'Del Peak 28(12q24.33) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 28(12Q24.33) MUTATED	40	68.5 (8.2)
DEL PEAK 28(12Q24.33) WILD-TYPE	381	62.9 (11.2)

Figure S111. Get High-res Image Gene #75: 'Del Peak 28(12q24.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 28(12q24.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.55e-11 (Chi-square test), Q value = 6.7e-09

Table S112. Gene #75: 'Del Peak 28(12q24.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 28(12Q24.33) MUTATED	14	0	0	0	0	1	25
DEL PEAK 28(12Q24.33) WILD-TYPE	297	3	8	2	7	16	49

Figure S112. Get High-res Image Gene #75: 'Del Peak 28(12q24.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 29(13q14.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000253 (Chi-square test), Q value = 0.089

Table S113. Gene #76: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 29(13Q14.2) MUTATED	34	0	0	0	2	4	24
DEL PEAK 29(13Q14.2) WILD-TYPE	277	3	8	2	5	13	50

Figure S113. Get High-res Image Gene #76: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 30(14q13.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.66e-12 (Chi-square test), Q value = 1.6e-09

Table S114. Gene #77: 'Del Peak 30(14q13.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 30(14Q13.1) MUTATED	18	0	0	0	0	5	28
DEL PEAK 30(14Q13.1) WILD-TYPE	293	3	8	2	7	12	46

Figure S114. Get High-res Image Gene #77: 'Del Peak 30(14q13.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 31(15q15.1) mutation analysis' versus 'AGE'

P value = 3.84e-09 (t-test), Q value = 1.6e-06

Table S115. Gene #78: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 31(15Q15.1) MUTATED	95	68.5 (8.5)
DEL PEAK 31(15Q15.1) WILD-TYPE	326	61.9 (11.3)

Figure S115. Get High-res Image Gene #78: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 31(15q15.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.3e-20 (Chi-square test), Q value = 3.9e-17

Table S116. Gene #78: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 31(15Q15.1) MUTATED	38	0	0	0	2	7	48
DEL PEAK 31(15Q15.1) WILD-TYPE	273	3	8	2	5	10	26

Figure S116. Get High-res Image Gene #78: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 32(15q23) mutation analysis' versus 'AGE'

P value = 1.28e-06 (t-test), Q value = 5e-04

Table S117. Gene #79: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 32(15Q23) MUTATED	76	68.1 (8.3)
DEL PEAK 32(15Q23) WILD-TYPE	345	62.4 (11.4)

Figure S117. Get High-res Image Gene #79: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 32(15q23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.29e-19 (Chi-square test), Q value = 2.5e-16

Table S118. Gene #79: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 32(15Q23) MUTATED	27	0	0	0	2	5	42
DEL PEAK 32(15Q23) WILD-TYPE	284	3	8	2	5	12	32

Figure S118. Get High-res Image Gene #79: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 33(16p13.3) mutation analysis' versus 'AGE'

P value = 2.86e-08 (t-test), Q value = 1.2e-05

Table S119. Gene #80: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 33(16P13.3) MUTATED	59	69.3 (7.5)
DEL PEAK 33(16P13.3) WILD-TYPE	362	62.5 (11.3)

Figure S119. Get High-res Image Gene #80: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 33(16p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.3e-15 (Chi-square test), Q value = 1.1e-12

Table S120. Gene #80: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 33(16P13.3) MUTATED	21	0	0	0	0	4	34
DEL PEAK 33(16P13.3) WILD-TYPE	290	3	8	2	7	13	40

Figure S120. Get High-res Image Gene #80: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 34(16q21) mutation analysis' versus 'AGE'

P value = 2.92e-09 (t-test), Q value = 1.2e-06

Table S121. Gene #81: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 34(16Q21) MUTATED	108	68.1 (8.3)
DEL PEAK 34(16Q21) WILD-TYPE	313	61.8 (11.5)

Figure S121. Get High-res Image Gene #81: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 34(16q21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.21e-21 (Chi-square test), Q value = 3.4e-18

Table S122. Gene #81: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 34(16Q21) MUTATED	47	0	0	0	1	7	53
DEL PEAK 34(16Q21) WILD-TYPE	264	3	8	2	6	10	21

Figure S122. Get High-res Image Gene #81: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 35(16q22.3) mutation analysis' versus 'AGE'

P value = 6.5e-09 (t-test), Q value = 2.7e-06

Table S123. Gene #82: 'Del Peak 35(16q22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 35(16Q22.3) MUTATED	113	67.8 (8.0)
DEL PEAK 35(16Q22.3) WILD-TYPE	308	61.8 (11.6)

Figure S123. Get High-res Image Gene #82: 'Del Peak 35(16q22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 35(16q22.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.53e-21 (Chi-square test), Q value = 7.3e-19

Table S124. Gene #82: 'Del Peak 35(16q22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 35(16Q22.3) MUTATED	50	0	0	0	1	7	55
DEL PEAK 35(16Q22.3) WILD-TYPE	261	3	8	2	6	10	19

Figure S124. Get High-res Image Gene #82: 'Del Peak 35(16q22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 36(16q23.1) mutation analysis' versus 'AGE'

P value = 3.3e-08 (t-test), Q value = 1.4e-05

Table S125. Gene #83: 'Del Peak 36(16q23.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 36(16Q23.1) MUTATED	118	67.7 (8.7)
DEL PEAK 36(16Q23.1) WILD-TYPE	303	61.8 (11.5)

Figure S125. Get High-res Image Gene #83: 'Del Peak 36(16q23.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 36(16q23.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.23e-24 (Chi-square test), Q value = 1.1e-21

Table S126. Gene #83: 'Del Peak 36(16q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 36(16Q23.1) MUTATED	52	0	0	0	1	6	59
DEL PEAK 36(16Q23.1) WILD-TYPE	259	3	8	2	6	11	15

Figure S126. Get High-res Image Gene #83: 'Del Peak 36(16q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 36(16q23.1) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.000255 (Fisher's exact test), Q value = 0.089

Table S127. Gene #83: 'Del Peak 36(16q23.1) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients	NO	YES
ALL	318	104
DEL PEAK 36(16Q23.1) MUTATED	74	44
DEL PEAK 36(16Q23.1) WILD-TYPE	244	60

Figure S127. Get High-res Image Gene #83: 'Del Peak 36(16q23.1) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Del Peak 37(17p13.3) mutation analysis' versus 'AGE'

P value = 3.37e-06 (t-test), Q value = 0.0013

Table S128. Gene #84: 'Del Peak 37(17p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 37(17P13.3) MUTATED	77	67.7 (7.9)
DEL PEAK 37(17P13.3) WILD-TYPE	344	62.5 (11.5)

Figure S128. Get High-res Image Gene #84: 'Del Peak 37(17p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 37(17p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.13e-18 (Chi-square test), Q value = 9.9e-16

Table S129. Gene #84: 'Del Peak 37(17p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 37(17P13.3) MUTATED	27	0	0	0	2	8	40
DEL PEAK 37(17P13.3) WILD-TYPE	284	3	8	2	5	9	34

Figure S129. Get High-res Image Gene #84: 'Del Peak 37(17p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 38(17p11.2) mutation analysis' versus 'AGE'

P value = 2.56e-08 (t-test), Q value = 1.1e-05

Table S130. Gene #85: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 38(17P11.2) MUTATED	83	68.4 (8.0)
DEL PEAK 38(17P11.2) WILD-TYPE	338	62.2 (11.4)

Figure S130. Get High-res Image Gene #85: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 38(17p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.36e-26 (Chi-square test), Q value = 2.1e-23

Table S131. Gene #85: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 38(17P11.2) MUTATED	26	0	0	0	1	8	48
DEL PEAK 38(17P11.2) WILD-TYPE	285	3	8	2	6	9	26

Figure S131. Get High-res Image Gene #85: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 39(17q11.2) mutation analysis' versus 'AGE'

P value = 6.43e-07 (t-test), Q value = 0.00026

Table S132. Gene #86: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 39(17Q11.2) MUTATED	70	68.2 (7.7)
DEL PEAK 39(17Q11.2) WILD-TYPE	351	62.5 (11.4)

Figure S132. Get High-res Image Gene #86: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 39(17q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.65e-12 (Chi-square test), Q value = 4.2e-09

Table S133. Gene #86: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 39(17Q11.2) MUTATED	29	0	0	0	2	5	34
DEL PEAK 39(17Q11.2) WILD-TYPE	282	3	8	2	5	12	40

Figure S133. Get High-res Image Gene #86: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 40(17q21.31) mutation analysis' versus 'AGE'

P value = 5.17e-06 (t-test), Q value = 0.002

Table S134. Gene #87: 'Del Peak 40(17q21.31) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 40(17Q21.31) MUTATED	67	68.3 (8.7)
DEL PEAK 40(17Q21.31) WILD-TYPE	354	62.5 (11.3)

Figure S134. Get High-res Image Gene #87: 'Del Peak 40(17q21.31) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 40(17q21.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.52e-11 (Chi-square test), Q value = 3.2e-08

Table S135. Gene #87: 'Del Peak 40(17q21.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 40(17Q21.31) MUTATED	29	0	0	0	1	4	33
DEL PEAK 40(17Q21.31) WILD-TYPE	282	3	8	2	6	13	41

Figure S135. Get High-res Image Gene #87: 'Del Peak 40(17q21.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 41(18q23) mutation analysis' versus 'AGE'

P value = 0.000312 (t-test), Q value = 0.11

Table S136. Gene #88: 'Del Peak 41(18q23) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 41(18Q23) MUTATED	68	67.3 (8.9)
DEL PEAK 41(18Q23) WILD-TYPE	353	62.7 (11.3)

Figure S136. Get High-res Image Gene #88: 'Del Peak 41(18q23) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 41(18q23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.37e-15 (Chi-square test), Q value = 3.3e-12

Table S137. Gene #88: 'Del Peak 41(18q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 41(18Q23) MUTATED	25	0	0	0	2	5	36
DEL PEAK 41(18Q23) WILD-TYPE	286	3	8	2	5	12	38

Figure S137. Get High-res Image Gene #88: 'Del Peak 41(18q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 42(19p13.3) mutation analysis' versus 'AGE'

P value = 1.27e-13 (t-test), Q value = 5.7e-11

Table S138. Gene #89: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 42(19P13.3) MUTATED	106	69.3 (8.0)
DEL PEAK 42(19P13.3) WILD-TYPE	315	61.4 (11.3)

Figure S138. Get High-res Image Gene #89: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 42(19p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.64e-41 (Chi-square test), Q value = 8e-39

Table S139. Gene #89: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 42(19P13.3) MUTATED	32	0	0	0	1	7	66
DEL PEAK 42(19P13.3) WILD-TYPE	279	3	8	2	6	10	8

Figure S139. Get High-res Image Gene #89: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 42(19p13.3) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.000633 (Fisher's exact test), Q value = 0.21

Table S140. Gene #89: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients	NO	YES
ALL	318	104
DEL PEAK 42(19P13.3) MUTATED	66	40
DEL PEAK 42(19P13.3) WILD-TYPE	252	64

Figure S140. Get High-res Image Gene #89: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Del Peak 43(19p12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.4e-07 (Chi-square test), Q value = 9.6e-05

Table S141. Gene #90: 'Del Peak 43(19p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 43(19P12) MUTATED	11	0	0	0	2	4	17
DEL PEAK 43(19P12) WILD-TYPE	300	3	8	2	5	13	57

Figure S141. Get High-res Image Gene #90: 'Del Peak 43(19p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 44(19q13.43) mutation analysis' versus 'AGE'

P value = 1.89e-05 (t-test), Q value = 0.0071

Table S142. Gene #91: 'Del Peak 44(19q13.43) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 44(19Q13.43) MUTATED	44	69.4 (8.7)
DEL PEAK 44(19Q13.43) WILD-TYPE	377	62.7 (11.2)

Figure S142. Get High-res Image Gene #91: 'Del Peak 44(19q13.43) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 44(19q13.43) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.86e-15 (Chi-square test), Q value = 2.2e-12

Table S143. Gene #91: 'Del Peak 44(19q13.43) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 44(19Q13.43) MUTATED	12	0	0	0	0	4	28
DEL PEAK 44(19Q13.43) WILD-TYPE	299	3	8	2	7	13	46

Figure S143. Get High-res Image Gene #91: 'Del Peak 44(19q13.43) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 48(22q12.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.05e-05 (Chi-square test), Q value = 0.004

Table S144. Gene #95: 'Del Peak 48(22q12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 48(22Q12.1) MUTATED	33	0	0	0	1	7	24
DEL PEAK 48(22Q12.1) WILD-TYPE	278	3	8	2	6	10	50

Figure S144. Get High-res Image Gene #95: 'Del Peak 48(22q12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 49(22q13.31) mutation analysis' versus 'AGE'

P value = 5.46e-08 (t-test), Q value = 2.2e-05

Table S145. Gene #96: 'Del Peak 49(22q13.31) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 49(22Q13.31) MUTATED	92	68.5 (9.1)
DEL PEAK 49(22Q13.31) WILD-TYPE	329	62.0 (11.2)

Figure S145. Get High-res Image Gene #96: 'Del Peak 49(22q13.31) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 49(22q13.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.24e-17 (Chi-square test), Q value = 2e-14

Table S146. Gene #96: 'Del Peak 49(22q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 49(22Q13.31) MUTATED	39	0	0	0	1	7	45
DEL PEAK 49(22Q13.31) WILD-TYPE	272	3	8	2	6	10	29

Figure S146. Get High-res Image Gene #96: 'Del Peak 49(22q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 50(Xp21.1) mutation analysis' versus 'AGE'

P value = 5.64e-05 (t-test), Q value = 0.021

Table S147. Gene #97: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	421	63.4 (11.1)
DEL PEAK 50(XP21.1) MUTATED	60	68.0 (8.6)
DEL PEAK 50(XP21.1) WILD-TYPE	361	62.7 (11.3)

Figure S147. Get High-res Image Gene #97: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 50(Xp21.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.55e-13 (Chi-square test), Q value = 2.9e-10

Table S148. Gene #97: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2)	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3)	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	311	3	8	2	7	17	74
DEL PEAK 50(XP21.1) MUTATED	24	0	0	0	1	2	33
DEL PEAK 50(XP21.1) WILD-TYPE	287	3	8	2	6	15	41

Figure S148. Get High-res Image Gene #97: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

Methods & Data

Input

Copy number data file = All Lesions File (all_lesions.conf_##.txt, where ## is the confidence level). The all lesions file is from GISTIC pipeline and summarizes the results from the GISTIC run. It contains data about the significant regions of amplification and deletion as well as which samples are amplified or deleted in each of these regions. The identified regions are listed down the first column, and the samples are listed across the first row, starting in column 10.
Clinical data file = UCEC.clin.merged.picked.txt
Number of patients = 422
Number of copy number variation regions = 97
Number of selected clinical features = 5
Exclude regions that fewer than K tumors have alterations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene cnvs were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene cnvs using 't.test' function in R

Chi-square test

For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.

References

[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)

[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)

[3] Greenwood and Nikulin, A guide to chi-squared testing, Wiley, New York. ISBN 047155779X (1996)

[4] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)

[5] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)

[6] GISTIC_version2

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