Uterine Corpus Endometrioid Carcinoma: Correlation between copy number variation genes and selected clinical features
Maintained by TCGA GDAC Team (Broad Institute/Dana-Farber Cancer Institute/Harvard Medical School)
Overview
Introduction

This pipeline computes the correlation between significant copy number variation (cnv) genes and selected clinical features.

Summary

Testing the association between copy number variation of 98 peak regions and 5 clinical features across 443 patients, 159 significant findings detected with Q value < 0.25.

  • Amp Peak 1(1p35.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 2(1p34.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 3(1p22.3) cnvs correlated to 'AGE'.

  • Amp Peak 4(1q21.3) cnvs correlated to 'AGE'.

  • Amp Peak 5(1q22) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 7(2p23.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Amp Peak 8(2q13) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 9(3p25.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 11(3q26.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 12(3q26.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 13(4p16.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 14(5p15.33) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Amp Peak 15(5q35.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 16(6p24.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 17(6q25.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Amp Peak 18(7q22.1) cnvs correlated to 'Time to Death'.

  • Amp Peak 19(8p11.21) cnvs correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 20(8q24.21) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Amp Peak 21(8q24.21) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Amp Peak 22(9p24.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Amp Peak 23(9q34.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 25(11p11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 26(11q13.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Amp Peak 27(12p12.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Amp Peak 28(12q13.11) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Amp Peak 29(12q13.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Amp Peak 30(13q34) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 31(14q24.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 32(14q32.33) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 33(16p11.2) cnvs correlated to 'AGE',  'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.

  • Amp Peak 34(17q11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 35(17q12) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 36(17q25.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 37(18p11.31) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 38(18q11.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Amp Peak 39(19p13.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 40(19p13.11) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 41(19q12) cnvs correlated to 'AGE',  'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.

  • Amp Peak 42(20p13) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 43(20q11.21) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 44(20q13.12) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 45(20q13.33) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Amp Peak 46(22q12.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Del Peak 1(1p36.21) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 2(1p36.11) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 5(2q22.1) cnvs correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 6(2q37.3) cnvs correlated to 'AGE'.

  • Del Peak 7(3p14.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 8(3q13.31) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Del Peak 9(4p16.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 10(4p15.31) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 11(4q22.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 12(4q34.3) cnvs correlated to 'AGE',  'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.

  • Del Peak 13(5q11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 14(6q26) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Del Peak 15(7p22.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 16(7q11.22) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 17(7q31.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 18(7q36.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 19(8p23.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Del Peak 20(9p23) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 21(9q34.11) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 22(10q23.31) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Del Peak 23(11p15.5) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 24(11q14.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 25(11q25) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 26(12q23.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Del Peak 27(12q24.33) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 28(13q11) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Del Peak 29(13q14.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 30(14q13.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Del Peak 31(15q15.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 32(15q23) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 33(16p13.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 34(16q21) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 35(16q23.1) cnvs correlated to 'AGE',  'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.

  • Del Peak 36(17p13.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 37(17p12) cnvs correlated to 'AGE',  'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.

  • Del Peak 38(17p11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 39(17q11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 40(17q21.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 41(18q23) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Del Peak 42(19p13.3) cnvs correlated to 'AGE',  'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.

  • Del Peak 43(19p12) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Del Peak 44(19q13.43) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Del Peak 46(22q11.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 47(22q12.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.

  • Del Peak 48(22q13.31) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 49(22q13.32) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • Del Peak 50(Xp21.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between significant copy number variation of 98 regions and 5 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 159 significant findings detected.

Clinical
Features 		Time
to
Death 		AGE HISTOLOGICAL
TYPE 		RADIATIONS
RADIATION
REGIMENINDICATION 		NEOADJUVANT
THERAPY
nCNV (%) nWild-Type logrank test t-test Chi-square test Fisher's exact test Fisher's exact test
Amp Peak 33(16p11 2) 46 (10%) 397 0.0814
(1.00) 		0.000137
(0.0486) 		5.3e-14
(2.37e-11) 		1
(1.00) 		0.000162
(0.0569)
Amp Peak 41(19q12) 80 (18%) 363 0.00193
(0.615) 		2.8e-10
(1.2e-07) 		8.43e-37
(4.12e-34) 		0.686
(1.00) 		0.000405
(0.137)
Del Peak 12(4q34 3) 90 (20%) 353 0.0248
(1.00) 		2.13e-05
(0.00804) 		1.43e-23
(6.93e-21) 		0.52
(1.00) 		4.2e-05
(0.0156)
Del Peak 35(16q23 1) 126 (28%) 317 0.0591
(1.00) 		1e-07
(4.09e-05) 		1.19e-24
(5.79e-22) 		0.422
(1.00) 		0.0003
(0.103)
Del Peak 37(17p12) 96 (22%) 347 0.0692
(1.00) 		3.09e-07
(0.000125) 		1.12e-24
(5.47e-22) 		0.53
(1.00) 		0.000622
(0.207)
Del Peak 42(19p13 3) 115 (26%) 328 0.0133
(1.00) 		5.3e-12
(2.33e-09) 		1.23e-44
(6.03e-42) 		0.344
(1.00) 		0.00032
(0.109)
Amp Peak 1(1p35 2) 40 (9%) 403 0.959
(1.00) 		0.000124
(0.0443) 		3.33e-10
(1.42e-07) 		1
(1.00) 		0.049
(1.00)
Amp Peak 2(1p34 2) 50 (11%) 393 0.574
(1.00) 		0.000133
(0.0473) 		3.57e-16
(1.64e-13) 		0.413
(1.00) 		0.0349
(1.00)
Amp Peak 5(1q22) 204 (46%) 239 0.0367
(1.00) 		1.65e-07
(6.72e-05) 		0.000233
(0.08) 		0.533
(1.00) 		0.823
(1.00)
Amp Peak 8(2q13) 88 (20%) 355 0.015
(1.00) 		0.000163
(0.0571) 		1e-14
(4.54e-12) 		0.795
(1.00) 		0.0506
(1.00)
Amp Peak 9(3p25 1) 60 (14%) 383 0.368
(1.00) 		0.000188
(0.0658) 		2.57e-09
(1.08e-06) 		0.172
(1.00) 		0.624
(1.00)
Amp Peak 11(3q26 2) 128 (29%) 315 0.143
(1.00) 		3.51e-09
(1.48e-06) 		6.17e-22
(2.96e-19) 		0.17
(1.00) 		0.00126
(0.409)
Amp Peak 12(3q26 2) 121 (27%) 322 0.0815
(1.00) 		3.66e-07
(0.000147) 		1.03e-22
(4.95e-20) 		0.245
(1.00) 		0.00577
(1.00)
Amp Peak 13(4p16 3) 39 (9%) 404 0.916
(1.00) 		1.74e-06
(0.000684) 		5.89e-15
(2.68e-12) 		0.715
(1.00) 		0.0298
(1.00)
Amp Peak 15(5q35 3) 39 (9%) 404 0.11
(1.00) 		0.000489
(0.165) 		3.21e-07
(0.000129) 		0.365
(1.00) 		0.554
(1.00)
Amp Peak 16(6p24 2) 83 (19%) 360 0.844
(1.00) 		9.78e-07
(0.000387) 		1.61e-17
(7.52e-15) 		0.232
(1.00) 		0.152
(1.00)
Amp Peak 19(8p11 21) 130 (29%) 313 1.61e-05
(0.00615) 		0.466
(1.00) 		1.23e-06
(0.000483) 		0.0411
(1.00) 		0.221
(1.00)
Amp Peak 23(9q34 3) 31 (7%) 412 0.0816
(1.00) 		0.000508
(0.171) 		2.26e-06
(0.000887) 		0.839
(1.00) 		0.125
(1.00)
Amp Peak 25(11p11 2) 37 (8%) 406 0.0376
(1.00) 		0.00022
(0.0761) 		2.91e-07
(0.000118) 		0.852
(1.00) 		0.225
(1.00)
Amp Peak 30(13q34) 40 (9%) 403 0.665
(1.00) 		7e-07
(0.000278) 		9.91e-11
(4.27e-08) 		1
(1.00) 		0.176
(1.00)
Amp Peak 31(14q24 3) 48 (11%) 395 0.504
(1.00) 		1.78e-05
(0.00675) 		2.5e-11
(1.09e-08) 		0.182
(1.00) 		0.0108
(1.00)
Amp Peak 32(14q32 33) 57 (13%) 386 0.182
(1.00) 		0.000211
(0.0731) 		6.76e-09
(2.84e-06) 		0.124
(1.00) 		0.0186
(1.00)
Amp Peak 34(17q11 2) 52 (12%) 391 0.0461
(1.00) 		0.000221
(0.0763) 		6.6e-17
(3.06e-14) 		0.748
(1.00) 		0.0246
(1.00)
Amp Peak 35(17q12) 53 (12%) 390 0.0649
(1.00) 		5.99e-05
(0.0221) 		7.29e-18
(3.43e-15) 		0.75
(1.00) 		0.00563
(1.00)
Amp Peak 36(17q25 1) 74 (17%) 369 0.0443
(1.00) 		5.73e-05
(0.0211) 		8.63e-16
(3.95e-13) 		1
(1.00) 		0.00674
(1.00)
Amp Peak 37(18p11 31) 66 (15%) 377 0.488
(1.00) 		0.000145
(0.0512) 		1.67e-18
(7.86e-16) 		0.0578
(1.00) 		0.877
(1.00)
Amp Peak 39(19p13 2) 69 (16%) 374 0.665
(1.00) 		3.81e-11
(1.65e-08) 		6.72e-18
(3.16e-15) 		0.2
(1.00) 		0.644
(1.00)
Amp Peak 40(19p13 11) 68 (15%) 375 0.607
(1.00) 		1.15e-10
(4.93e-08) 		3.14e-20
(1.5e-17) 		0.0837
(1.00) 		0.539
(1.00)
Amp Peak 42(20p13) 86 (19%) 357 0.175
(1.00) 		9.5e-05
(0.0343) 		2.52e-12
(1.11e-09) 		0.239
(1.00) 		0.00443
(1.00)
Amp Peak 43(20q11 21) 106 (24%) 337 0.0389
(1.00) 		1.53e-07
(6.24e-05) 		1.65e-23
(7.95e-21) 		0.0682
(1.00) 		0.0126
(1.00)
Amp Peak 44(20q13 12) 111 (25%) 332 0.304
(1.00) 		4.41e-08
(1.81e-05) 		1.8e-19
(8.54e-17) 		0.0164
(1.00) 		0.00956
(1.00)
Amp Peak 45(20q13 33) 109 (25%) 334 0.333
(1.00) 		1.72e-07
(6.98e-05) 		2.45e-15
(1.12e-12) 		0.00545
(1.00) 		0.0199
(1.00)
Del Peak 1(1p36 21) 53 (12%) 390 0.412
(1.00) 		6.57e-05
(0.0241) 		3.13e-08
(1.29e-05) 		0.525
(1.00) 		0.0376
(1.00)
Del Peak 2(1p36 11) 58 (13%) 385 0.321
(1.00) 		7.28e-05
(0.0266) 		8.44e-12
(3.7e-09) 		0.759
(1.00) 		0.0972
(1.00)
Del Peak 5(2q22 1) 34 (8%) 409 1.1e-08
(4.6e-06) 		0.00772
(1.00) 		9.51e-05
(0.0343) 		0.0181
(1.00) 		1
(1.00)
Del Peak 7(3p14 2) 56 (13%) 387 0.797
(1.00) 		2.76e-05
(0.0103) 		2.58e-14
(1.16e-11) 		0.437
(1.00) 		0.13
(1.00)
Del Peak 9(4p16 3) 65 (15%) 378 0.139
(1.00) 		6.87e-05
(0.0252) 		6.17e-13
(2.73e-10) 		0.558
(1.00) 		0.026
(1.00)
Del Peak 10(4p15 31) 64 (14%) 379 0.137
(1.00) 		9.3e-05
(0.0337) 		8.54e-12
(3.73e-09) 		0.141
(1.00) 		0.427
(1.00)
Del Peak 11(4q22 1) 76 (17%) 367 0.00763
(1.00) 		1.31e-05
(0.00503) 		5.34e-24
(2.59e-21) 		0.217
(1.00) 		0.00178
(0.568)
Del Peak 13(5q11 2) 76 (17%) 367 0.0615
(1.00) 		7.58e-05
(0.0276) 		5.75e-23
(2.77e-20) 		0.681
(1.00) 		0.0531
(1.00)
Del Peak 15(7p22 3) 56 (13%) 387 0.0101
(1.00) 		2.62e-05
(0.00986) 		2.18e-13
(9.7e-11) 		0.642
(1.00) 		0.0643
(1.00)
Del Peak 16(7q11 22) 31 (7%) 412 0.55
(1.00) 		1.91e-05
(0.00723) 		3.17e-07
(0.000128) 		0.688
(1.00) 		0.0495
(1.00)
Del Peak 17(7q31 1) 39 (9%) 404 0.696
(1.00) 		3.24e-06
(0.00127) 		1.01e-17
(4.72e-15) 		0.715
(1.00) 		0.00128
(0.414)
Del Peak 18(7q36 3) 49 (11%) 394 0.582
(1.00) 		3.53e-08
(1.45e-05) 		2.76e-17
(1.28e-14) 		1
(1.00) 		0.0122
(1.00)
Del Peak 20(9p23) 50 (11%) 393 0.397
(1.00) 		0.000379
(0.129) 		6.75e-10
(2.86e-07) 		0.413
(1.00) 		0.158
(1.00)
Del Peak 21(9q34 11) 101 (23%) 342 0.319
(1.00) 		2.55e-10
(1.09e-07) 		1.18e-16
(5.45e-14) 		0.324
(1.00) 		0.011
(1.00)
Del Peak 23(11p15 5) 76 (17%) 367 0.00871
(1.00) 		2.81e-08
(1.16e-05) 		1.03e-21
(4.91e-19) 		0.13
(1.00) 		0.0255
(1.00)
Del Peak 24(11q14 1) 50 (11%) 393 0.052
(1.00) 		1.04e-05
(0.00399) 		1.73e-13
(7.73e-11) 		0.624
(1.00) 		0.0204
(1.00)
Del Peak 25(11q25) 68 (15%) 375 0.00338
(1.00) 		8.41e-05
(0.0305) 		3.19e-14
(1.44e-11) 		0.0433
(1.00) 		0.0431
(1.00)
Del Peak 27(12q24 33) 43 (10%) 400 0.0812
(1.00) 		0.000113
(0.0405) 		4.79e-14
(2.15e-11) 		0.114
(1.00) 		0.0371
(1.00)
Del Peak 29(13q14 2) 71 (16%) 372 0.034
(1.00) 		0.000606
(0.202) 		0.000306
(0.105) 		0.158
(1.00) 		0.761
(1.00)
Del Peak 31(15q15 1) 102 (23%) 341 0.0318
(1.00) 		1.54e-08
(6.4e-06) 		2.67e-20
(1.27e-17) 		0.0654
(1.00) 		0.0116
(1.00)
Del Peak 32(15q23) 82 (19%) 361 0.0562
(1.00) 		8.73e-06
(0.00336) 		6.75e-20
(3.21e-17) 		0.233
(1.00) 		0.0431
(1.00)
Del Peak 33(16p13 3) 61 (14%) 382 0.0325
(1.00) 		2.74e-08
(1.13e-05) 		1.77e-15
(8.08e-13) 		0.549
(1.00) 		0.259
(1.00)
Del Peak 34(16q21) 116 (26%) 327 0.0479
(1.00) 		1.51e-08
(6.32e-06) 		4.27e-21
(2.04e-18) 		0.289
(1.00) 		0.00499
(1.00)
Del Peak 36(17p13 3) 84 (19%) 359 0.115
(1.00) 		4.09e-05
(0.0152) 		3.11e-16
(1.43e-13) 		0.292
(1.00) 		0.00257
(0.814)
Del Peak 38(17p11 2) 87 (20%) 356 0.0388
(1.00) 		3.63e-06
(0.00141) 		1.97e-17
(9.2e-15) 		0.437
(1.00) 		0.0908
(1.00)
Del Peak 39(17q11 2) 77 (17%) 366 0.581
(1.00) 		1.6e-05
(0.00612) 		3.05e-10
(1.3e-07) 		0.174
(1.00) 		0.184
(1.00)
Del Peak 40(17q21 2) 82 (19%) 361 0.13
(1.00) 		2.13e-05
(0.00804) 		5.08e-14
(2.28e-11) 		0.144
(1.00) 		0.115
(1.00)
Del Peak 46(22q11 1) 65 (15%) 378 0.405
(1.00) 		4.63e-05
(0.0171) 		0.000195
(0.068) 		0.0283
(1.00) 		0.637
(1.00)
Del Peak 48(22q13 31) 99 (22%) 344 0.0156
(1.00) 		1.78e-08
(7.4e-06) 		1.75e-16
(8.07e-14) 		0.264
(1.00) 		0.0313
(1.00)
Del Peak 49(22q13 32) 105 (24%) 338 0.0141
(1.00) 		4.1e-07
(0.000164) 		2.5e-17
(1.16e-14) 		0.0688
(1.00) 		0.0668
(1.00)
Del Peak 50(Xp21 1) 62 (14%) 381 0.00386
(1.00) 		0.000137
(0.0486) 		4.19e-13
(1.86e-10) 		0.55
(1.00) 		0.519
(1.00)
Amp Peak 3(1p22 3) 73 (16%) 370 0.702
(1.00) 		0.000573
(0.192) 		0.00943
(1.00) 		0.889
(1.00) 		0.229
(1.00)
Amp Peak 4(1q21 3) 192 (43%) 251 0.165
(1.00) 		3.55e-06
(0.00138) 		0.00431
(1.00) 		0.602
(1.00) 		0.176
(1.00)
Amp Peak 7(2p23 2) 93 (21%) 350 0.00562
(1.00) 		0.00263
(0.827) 		2.21e-10
(9.47e-08) 		0.0557
(1.00) 		0.173
(1.00)
Amp Peak 14(5p15 33) 64 (14%) 379 0.051
(1.00) 		0.00529
(1.00) 		2.61e-16
(1.2e-13) 		0.558
(1.00) 		0.265
(1.00)
Amp Peak 17(6q25 1) 64 (14%) 379 0.818
(1.00) 		0.00919
(1.00) 		0.000161
(0.0567) 		0.558
(1.00) 		0.634
(1.00)
Amp Peak 18(7q22 1) 69 (16%) 374 0.000492
(0.166) 		0.0361
(1.00) 		0.0437
(1.00) 		0.117
(1.00) 		1
(1.00)
Amp Peak 20(8q24 21) 161 (36%) 282 0.00107
(0.35) 		0.594
(1.00) 		5.85e-11
(2.53e-08) 		0.0523
(1.00) 		0.00362
(1.00)
Amp Peak 21(8q24 21) 169 (38%) 274 0.00576
(1.00) 		0.263
(1.00) 		1.1e-11
(4.79e-09) 		0.014
(1.00) 		0.0155
(1.00)
Amp Peak 22(9p24 2) 48 (11%) 395 0.753
(1.00) 		0.00528
(1.00) 		3.9e-07
(0.000156) 		0.182
(1.00) 		0.0491
(1.00)
Amp Peak 26(11q13 2) 56 (13%) 387 0.0967
(1.00) 		0.00107
(0.35) 		1.07e-06
(0.000424) 		1
(1.00) 		0.029
(1.00)
Amp Peak 27(12p12 1) 67 (15%) 376 0.756
(1.00) 		0.49
(1.00) 		2.29e-06
(0.000896) 		0.664
(1.00) 		1
(1.00)
Amp Peak 28(12q13 11) 66 (15%) 377 0.804
(1.00) 		0.855
(1.00) 		6.59e-06
(0.00255) 		0.191
(1.00) 		0.754
(1.00)
Amp Peak 29(12q13 2) 74 (17%) 369 0.908
(1.00) 		0.0707
(1.00) 		7.53e-06
(0.00291) 		0.0515
(1.00) 		0.882
(1.00)
Amp Peak 38(18q11 2) 49 (11%) 394 0.119
(1.00) 		0.013
(1.00) 		6.55e-13
(2.9e-10) 		0.624
(1.00) 		1
(1.00)
Amp Peak 46(22q12 2) 41 (9%) 402 0.606
(1.00) 		0.00374
(1.00) 		7.21e-19
(3.41e-16) 		0.285
(1.00) 		0.246
(1.00)
Del Peak 6(2q37 3) 38 (9%) 405 0.484
(1.00) 		0.000706
(0.234) 		0.0374
(1.00) 		0.461
(1.00) 		0.428
(1.00)
Del Peak 8(3q13 31) 21 (5%) 422 0.92
(1.00) 		0.00321
(1.00) 		3.18e-05
(0.0119) 		0.631
(1.00) 		0.297
(1.00)
Del Peak 14(6q26) 34 (8%) 409 0.224
(1.00) 		0.00929
(1.00) 		8.63e-09
(3.62e-06) 		0.846
(1.00) 		0.406
(1.00)
Del Peak 19(8p23 2) 79 (18%) 364 0.312
(1.00) 		0.00294
(0.922) 		2.72e-25
(1.33e-22) 		0.686
(1.00) 		0.00195
(0.618)
Del Peak 22(10q23 31) 52 (12%) 391 0.108
(1.00) 		0.0141
(1.00) 		0.000137
(0.0486) 		0.0775
(1.00) 		0.386
(1.00)
Del Peak 26(12q23 1) 33 (7%) 410 0.0484
(1.00) 		0.00319
(0.999) 		5.45e-11
(2.36e-08) 		0.556
(1.00) 		0.0171
(1.00)
Del Peak 28(13q11) 67 (15%) 376 0.0122
(1.00) 		0.000947
(0.312) 		1.11e-09
(4.7e-07) 		0.251
(1.00) 		0.213
(1.00)
Del Peak 30(14q13 1) 54 (12%) 389 0.000909
(0.301) 		0.00139
(0.45) 		8.18e-12
(3.59e-09) 		0.53
(1.00) 		0.0877
(1.00)
Del Peak 41(18q23) 73 (16%) 370 0.0118
(1.00) 		0.00171
(0.547) 		6.41e-15
(2.91e-12) 		0.00509
(1.00) 		0.452
(1.00)
Del Peak 43(19p12) 37 (8%) 406 0.1
(1.00) 		0.0484
(1.00) 		5.16e-07
(0.000205) 		0.268
(1.00) 		0.225
(1.00)
Del Peak 44(19q13 43) 47 (11%) 396 0.00148
(0.478) 		0.00121
(0.396) 		1.63e-14
(7.38e-12) 		1
(1.00) 		0.00642
(1.00)
Del Peak 47(22q12 1) 70 (16%) 373 0.206
(1.00) 		0.00151
(0.483) 		3.78e-05
(0.0141) 		0.0904
(1.00) 		0.125
(1.00)
Amp Peak 6(1q42 3) 182 (41%) 261 0.256
(1.00) 		0.00113
(0.369) 		0.182
(1.00) 		0.6
(1.00) 		0.651
(1.00)
Amp Peak 10(3p14 1) 48 (11%) 395 0.00429
(1.00) 		0.00881
(1.00) 		0.00376
(1.00) 		0.0441
(1.00) 		1
(1.00)
Amp Peak 24(10q22 2) 121 (27%) 322 0.198
(1.00) 		0.431
(1.00) 		0.18
(1.00) 		0.642
(1.00) 		0.0446
(1.00)
Amp Peak 47(Xp11 23) 71 (16%) 372 0.432
(1.00) 		0.31
(1.00) 		0.09
(1.00) 		0.0473
(1.00) 		0.224
(1.00)
Amp Peak 48(Xq28) 72 (16%) 371 0.00898
(1.00) 		0.101
(1.00) 		0.00591
(1.00) 		1
(1.00) 		1
(1.00)
Del Peak 3(1q43) 7 (2%) 436 0.0284
(1.00) 		0.0217
(1.00) 		0.75
(1.00) 		0.108
(1.00) 		1
(1.00)
Del Peak 4(2p25 3) 22 (5%) 421 0.0276
(1.00) 		0.118
(1.00) 		0.042
(1.00) 		0.0981
(1.00) 		0.314
(1.00)
Del Peak 45(20p12 1) 24 (5%) 419 0.0777
(1.00) 		0.032
(1.00) 		0.0503
(1.00) 		0.819
(1.00) 		0.81
(1.00)
'Amp Peak 1(1p35.2) mutation analysis' versus 'AGE'

P value = 0.000124 (t-test), Q value = 0.044

Table S1.  Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 1(1P35.2) MUTATED 40 69.0 (8.5)
AMP PEAK 1(1P35.2) WILD-TYPE 402 63.0 (11.3)

Figure S1.  Get High-res Image Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 1(1p35.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.33e-10 (Chi-square test), Q value = 1.4e-07

Table S2.  Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 1(1P35.2) MUTATED 13 0 0 0 0 4 23
AMP PEAK 1(1P35.2) WILD-TYPE 314 3 8 2 7 14 55

Figure S2.  Get High-res Image Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 2(1p34.2) mutation analysis' versus 'AGE'

P value = 0.000133 (t-test), Q value = 0.047

Table S3.  Gene #2: 'Amp Peak 2(1p34.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 2(1P34.2) MUTATED 50 68.8 (9.5)
AMP PEAK 2(1P34.2) WILD-TYPE 392 62.9 (11.3)

Figure S3.  Get High-res Image Gene #2: 'Amp Peak 2(1p34.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 2(1p34.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.57e-16 (Chi-square test), Q value = 1.6e-13

Table S4.  Gene #2: 'Amp Peak 2(1p34.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 2(1P34.2) MUTATED 14 0 0 0 0 6 30
AMP PEAK 2(1P34.2) WILD-TYPE 313 3 8 2 7 12 48

Figure S4.  Get High-res Image Gene #2: 'Amp Peak 2(1p34.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 3(1p22.3) mutation analysis' versus 'AGE'

P value = 0.000573 (t-test), Q value = 0.19

Table S5.  Gene #3: 'Amp Peak 3(1p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 3(1P22.3) MUTATED 73 67.4 (9.9)
AMP PEAK 3(1P22.3) WILD-TYPE 369 62.8 (11.3)

Figure S5.  Get High-res Image Gene #3: 'Amp Peak 3(1p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 4(1q21.3) mutation analysis' versus 'AGE'

P value = 3.55e-06 (t-test), Q value = 0.0014

Table S6.  Gene #4: 'Amp Peak 4(1q21.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 4(1Q21.3) MUTATED 192 66.3 (10.5)
AMP PEAK 4(1Q21.3) WILD-TYPE 250 61.4 (11.4)

Figure S6.  Get High-res Image Gene #4: 'Amp Peak 4(1q21.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 5(1q22) mutation analysis' versus 'AGE'

P value = 1.65e-07 (t-test), Q value = 6.7e-05

Table S7.  Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 5(1Q22) MUTATED 204 66.5 (10.4)
AMP PEAK 5(1Q22) WILD-TYPE 238 61.0 (11.3)

Figure S7.  Get High-res Image Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 5(1q22) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000233 (Chi-square test), Q value = 0.08

Table S8.  Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 5(1Q22) MUTATED 138 0 1 1 2 8 54
AMP PEAK 5(1Q22) WILD-TYPE 189 3 7 1 5 10 24

Figure S8.  Get High-res Image Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 7(2p23.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.21e-10 (Chi-square test), Q value = 9.5e-08

Table S9.  Gene #7: 'Amp Peak 7(2p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 7(2P23.2) MUTATED 44 0 1 1 1 7 39
AMP PEAK 7(2P23.2) WILD-TYPE 283 3 7 1 6 11 39

Figure S9.  Get High-res Image Gene #7: 'Amp Peak 7(2p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 8(2q13) mutation analysis' versus 'AGE'

P value = 0.000163 (t-test), Q value = 0.057

Table S10.  Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 8(2Q13) MUTATED 87 67.1 (9.1)
AMP PEAK 8(2Q13) WILD-TYPE 355 62.7 (11.6)

Figure S10.  Get High-res Image Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 8(2q13) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1e-14 (Chi-square test), Q value = 4.5e-12

Table S11.  Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 8(2Q13) MUTATED 39 0 1 1 0 4 43
AMP PEAK 8(2Q13) WILD-TYPE 288 3 7 1 7 14 35

Figure S11.  Get High-res Image Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 9(3p25.1) mutation analysis' versus 'AGE'

P value = 0.000188 (t-test), Q value = 0.066

Table S12.  Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 9(3P25.1) MUTATED 60 68.6 (10.7)
AMP PEAK 9(3P25.1) WILD-TYPE 382 62.7 (11.1)

Figure S12.  Get High-res Image Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 9(3p25.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.57e-09 (Chi-square test), Q value = 1.1e-06

Table S13.  Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 9(3P25.1) MUTATED 28 0 0 0 1 1 30
AMP PEAK 9(3P25.1) WILD-TYPE 299 3 8 2 6 17 48

Figure S13.  Get High-res Image Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 11(3q26.2) mutation analysis' versus 'AGE'

P value = 3.51e-09 (t-test), Q value = 1.5e-06

Table S14.  Gene #11: 'Amp Peak 11(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 11(3Q26.2) MUTATED 128 68.1 (9.4)
AMP PEAK 11(3Q26.2) WILD-TYPE 314 61.7 (11.4)

Figure S14.  Get High-res Image Gene #11: 'Amp Peak 11(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 11(3q26.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.17e-22 (Chi-square test), Q value = 3e-19

Table S15.  Gene #11: 'Amp Peak 11(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 11(3Q26.2) MUTATED 59 0 0 0 2 7 60
AMP PEAK 11(3Q26.2) WILD-TYPE 268 3 8 2 5 11 18

Figure S15.  Get High-res Image Gene #11: 'Amp Peak 11(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 12(3q26.2) mutation analysis' versus 'AGE'

P value = 3.66e-07 (t-test), Q value = 0.00015

Table S16.  Gene #12: 'Amp Peak 12(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 12(3Q26.2) MUTATED 121 67.6 (9.4)
AMP PEAK 12(3Q26.2) WILD-TYPE 321 62.0 (11.5)

Figure S16.  Get High-res Image Gene #12: 'Amp Peak 12(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 12(3q26.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.03e-22 (Chi-square test), Q value = 4.9e-20

Table S17.  Gene #12: 'Amp Peak 12(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 12(3Q26.2) MUTATED 54 0 0 0 2 6 59
AMP PEAK 12(3Q26.2) WILD-TYPE 273 3 8 2 5 12 19

Figure S17.  Get High-res Image Gene #12: 'Amp Peak 12(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 13(4p16.3) mutation analysis' versus 'AGE'

P value = 1.74e-06 (t-test), Q value = 0.00068

Table S18.  Gene #13: 'Amp Peak 13(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 13(4P16.3) MUTATED 39 70.5 (8.2)
AMP PEAK 13(4P16.3) WILD-TYPE 403 62.9 (11.3)

Figure S18.  Get High-res Image Gene #13: 'Amp Peak 13(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 13(4p16.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.89e-15 (Chi-square test), Q value = 2.7e-12

Table S19.  Gene #13: 'Amp Peak 13(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 13(4P16.3) MUTATED 11 0 0 0 0 1 27
AMP PEAK 13(4P16.3) WILD-TYPE 316 3 8 2 7 17 51

Figure S19.  Get High-res Image Gene #13: 'Amp Peak 13(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 14(5p15.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.61e-16 (Chi-square test), Q value = 1.2e-13

Table S20.  Gene #14: 'Amp Peak 14(5p15.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 14(5P15.33) MUTATED 24 0 0 0 0 3 37
AMP PEAK 14(5P15.33) WILD-TYPE 303 3 8 2 7 15 41

Figure S20.  Get High-res Image Gene #14: 'Amp Peak 14(5p15.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 15(5q35.3) mutation analysis' versus 'AGE'

P value = 0.000489 (t-test), Q value = 0.17

Table S21.  Gene #15: 'Amp Peak 15(5q35.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 15(5Q35.3) MUTATED 39 69.7 (10.7)
AMP PEAK 15(5Q35.3) WILD-TYPE 403 62.9 (11.1)

Figure S21.  Get High-res Image Gene #15: 'Amp Peak 15(5q35.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 15(5q35.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.21e-07 (Chi-square test), Q value = 0.00013

Table S22.  Gene #15: 'Amp Peak 15(5q35.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 15(5Q35.3) MUTATED 15 0 0 0 1 2 21
AMP PEAK 15(5Q35.3) WILD-TYPE 312 3 8 2 6 16 57

Figure S22.  Get High-res Image Gene #15: 'Amp Peak 15(5q35.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 16(6p24.2) mutation analysis' versus 'AGE'

P value = 9.78e-07 (t-test), Q value = 0.00039

Table S23.  Gene #16: 'Amp Peak 16(6p24.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 16(6P24.2) MUTATED 83 68.7 (9.9)
AMP PEAK 16(6P24.2) WILD-TYPE 359 62.3 (11.2)

Figure S23.  Get High-res Image Gene #16: 'Amp Peak 16(6p24.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 16(6p24.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.61e-17 (Chi-square test), Q value = 7.5e-15

Table S24.  Gene #16: 'Amp Peak 16(6p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 16(6P24.2) MUTATED 35 0 0 0 0 4 44
AMP PEAK 16(6P24.2) WILD-TYPE 292 3 8 2 7 14 34

Figure S24.  Get High-res Image Gene #16: 'Amp Peak 16(6p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 17(6q25.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000161 (Chi-square test), Q value = 0.057

Table S25.  Gene #17: 'Amp Peak 17(6q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 17(6Q25.1) MUTATED 35 0 0 0 2 2 25
AMP PEAK 17(6Q25.1) WILD-TYPE 292 3 8 2 5 16 53

Figure S25.  Get High-res Image Gene #17: 'Amp Peak 17(6q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 18(7q22.1) mutation analysis' versus 'Time to Death'

P value = 0.000492 (logrank test), Q value = 0.17

Table S26.  Gene #18: 'Amp Peak 18(7q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 438 41 0.0 - 187.1 (15.8)
AMP PEAK 18(7Q22.1) MUTATED 67 13 0.0 - 113.2 (13.0)
AMP PEAK 18(7Q22.1) WILD-TYPE 371 28 0.1 - 187.1 (16.3)

Figure S26.  Get High-res Image Gene #18: 'Amp Peak 18(7q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Amp Peak 19(8p11.21) mutation analysis' versus 'Time to Death'

P value = 1.61e-05 (logrank test), Q value = 0.0062

Table S27.  Gene #19: 'Amp Peak 19(8p11.21) mutation analysis' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 438 41 0.0 - 187.1 (15.8)
AMP PEAK 19(8P11.21) MUTATED 128 22 0.0 - 113.2 (11.5)
AMP PEAK 19(8P11.21) WILD-TYPE 310 19 0.0 - 187.1 (16.9)

Figure S27.  Get High-res Image Gene #19: 'Amp Peak 19(8p11.21) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Amp Peak 19(8p11.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.23e-06 (Chi-square test), Q value = 0.00048

Table S28.  Gene #19: 'Amp Peak 19(8p11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 19(8P11.21) MUTATED 76 1 0 0 4 6 43
AMP PEAK 19(8P11.21) WILD-TYPE 251 2 8 2 3 12 35

Figure S28.  Get High-res Image Gene #19: 'Amp Peak 19(8p11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 20(8q24.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.85e-11 (Chi-square test), Q value = 2.5e-08

Table S29.  Gene #20: 'Amp Peak 20(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 20(8Q24.21) MUTATED 92 1 0 0 4 8 56
AMP PEAK 20(8Q24.21) WILD-TYPE 235 2 8 2 3 10 22

Figure S29.  Get High-res Image Gene #20: 'Amp Peak 20(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 21(8q24.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.1e-11 (Chi-square test), Q value = 4.8e-09

Table S30.  Gene #21: 'Amp Peak 21(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 21(8Q24.21) MUTATED 98 1 0 0 4 7 59
AMP PEAK 21(8Q24.21) WILD-TYPE 229 2 8 2 3 11 19

Figure S30.  Get High-res Image Gene #21: 'Amp Peak 21(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 22(9p24.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.9e-07 (Chi-square test), Q value = 0.00016

Table S31.  Gene #22: 'Amp Peak 22(9p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 22(9P24.2) MUTATED 21 0 0 0 1 2 24
AMP PEAK 22(9P24.2) WILD-TYPE 306 3 8 2 6 16 54

Figure S31.  Get High-res Image Gene #22: 'Amp Peak 22(9p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 23(9q34.3) mutation analysis' versus 'AGE'

P value = 0.000508 (t-test), Q value = 0.17

Table S32.  Gene #23: 'Amp Peak 23(9q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 23(9Q34.3) MUTATED 31 69.0 (8.0)
AMP PEAK 23(9Q34.3) WILD-TYPE 411 63.1 (11.4)

Figure S32.  Get High-res Image Gene #23: 'Amp Peak 23(9q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 23(9q34.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.26e-06 (Chi-square test), Q value = 0.00089

Table S33.  Gene #23: 'Amp Peak 23(9q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 23(9Q34.3) MUTATED 11 0 0 0 0 4 16
AMP PEAK 23(9Q34.3) WILD-TYPE 316 3 8 2 7 14 62

Figure S33.  Get High-res Image Gene #23: 'Amp Peak 23(9q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 25(11p11.2) mutation analysis' versus 'AGE'

P value = 0.00022 (t-test), Q value = 0.076

Table S34.  Gene #25: 'Amp Peak 25(11p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 25(11P11.2) MUTATED 37 69.7 (9.6)
AMP PEAK 25(11P11.2) WILD-TYPE 405 63.0 (11.2)

Figure S34.  Get High-res Image Gene #25: 'Amp Peak 25(11p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 25(11p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.91e-07 (Chi-square test), Q value = 0.00012

Table S35.  Gene #25: 'Amp Peak 25(11p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 25(11P11.2) MUTATED 14 0 0 0 0 3 20
AMP PEAK 25(11P11.2) WILD-TYPE 313 3 8 2 7 15 58

Figure S35.  Get High-res Image Gene #25: 'Amp Peak 25(11p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 26(11q13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.07e-06 (Chi-square test), Q value = 0.00042

Table S36.  Gene #26: 'Amp Peak 26(11q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 26(11Q13.2) MUTATED 28 0 0 0 0 2 26
AMP PEAK 26(11Q13.2) WILD-TYPE 299 3 8 2 7 16 52

Figure S36.  Get High-res Image Gene #26: 'Amp Peak 26(11q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 27(12p12.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.29e-06 (Chi-square test), Q value = 9e-04

Table S37.  Gene #27: 'Amp Peak 27(12p12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 27(12P12.1) MUTATED 34 0 1 0 1 2 29
AMP PEAK 27(12P12.1) WILD-TYPE 293 3 7 2 6 16 49

Figure S37.  Get High-res Image Gene #27: 'Amp Peak 27(12p12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 28(12q13.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.59e-06 (Chi-square test), Q value = 0.0026

Table S38.  Gene #28: 'Amp Peak 28(12q13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 28(12Q13.11) MUTATED 33 0 1 0 1 3 28
AMP PEAK 28(12Q13.11) WILD-TYPE 294 3 7 2 6 15 50

Figure S38.  Get High-res Image Gene #28: 'Amp Peak 28(12q13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 29(12q13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.53e-06 (Chi-square test), Q value = 0.0029

Table S39.  Gene #29: 'Amp Peak 29(12q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 29(12Q13.2) MUTATED 40 0 1 0 0 3 30
AMP PEAK 29(12Q13.2) WILD-TYPE 287 3 7 2 7 15 48

Figure S39.  Get High-res Image Gene #29: 'Amp Peak 29(12q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 30(13q34) mutation analysis' versus 'AGE'

P value = 7e-07 (t-test), Q value = 0.00028

Table S40.  Gene #30: 'Amp Peak 30(13q34) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 30(13Q34) MUTATED 40 69.9 (7.1)
AMP PEAK 30(13Q34) WILD-TYPE 402 62.9 (11.4)

Figure S40.  Get High-res Image Gene #30: 'Amp Peak 30(13q34) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 30(13q34) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.91e-11 (Chi-square test), Q value = 4.3e-08

Table S41.  Gene #30: 'Amp Peak 30(13q34) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 30(13Q34) MUTATED 13 0 0 0 0 3 24
AMP PEAK 30(13Q34) WILD-TYPE 314 3 8 2 7 15 54

Figure S41.  Get High-res Image Gene #30: 'Amp Peak 30(13q34) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 31(14q24.3) mutation analysis' versus 'AGE'

P value = 1.78e-05 (t-test), Q value = 0.0067

Table S42.  Gene #31: 'Amp Peak 31(14q24.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 31(14Q24.3) MUTATED 48 69.0 (8.4)
AMP PEAK 31(14Q24.3) WILD-TYPE 394 62.9 (11.4)

Figure S42.  Get High-res Image Gene #31: 'Amp Peak 31(14q24.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 31(14q24.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.5e-11 (Chi-square test), Q value = 1.1e-08

Table S43.  Gene #31: 'Amp Peak 31(14q24.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 31(14Q24.3) MUTATED 17 0 0 0 0 4 27
AMP PEAK 31(14Q24.3) WILD-TYPE 310 3 8 2 7 14 51

Figure S43.  Get High-res Image Gene #31: 'Amp Peak 31(14q24.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 32(14q32.33) mutation analysis' versus 'AGE'

P value = 0.000211 (t-test), Q value = 0.073

Table S44.  Gene #32: 'Amp Peak 32(14q32.33) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 32(14Q32.33) MUTATED 57 68.2 (9.4)
AMP PEAK 32(14Q32.33) WILD-TYPE 385 62.9 (11.3)

Figure S44.  Get High-res Image Gene #32: 'Amp Peak 32(14q32.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 32(14q32.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.76e-09 (Chi-square test), Q value = 2.8e-06

Table S45.  Gene #32: 'Amp Peak 32(14q32.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 32(14Q32.33) MUTATED 25 0 0 0 0 4 28
AMP PEAK 32(14Q32.33) WILD-TYPE 302 3 8 2 7 14 50

Figure S45.  Get High-res Image Gene #32: 'Amp Peak 32(14q32.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 33(16p11.2) mutation analysis' versus 'AGE'

P value = 0.000137 (t-test), Q value = 0.049

Table S46.  Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 33(16P11.2) MUTATED 46 68.5 (8.5)
AMP PEAK 33(16P11.2) WILD-TYPE 396 63.0 (11.4)

Figure S46.  Get High-res Image Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 33(16p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.3e-14 (Chi-square test), Q value = 2.4e-11

Table S47.  Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 33(16P11.2) MUTATED 15 0 0 0 0 2 29
AMP PEAK 33(16P11.2) WILD-TYPE 312 3 8 2 7 16 49

Figure S47.  Get High-res Image Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 33(16p11.2) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.000162 (Fisher's exact test), Q value = 0.057

Table S48.  Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients NO YES
ALL 338 105
AMP PEAK 33(16P11.2) MUTATED 24 22
AMP PEAK 33(16P11.2) WILD-TYPE 314 83

Figure S48.  Get High-res Image Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Amp Peak 34(17q11.2) mutation analysis' versus 'AGE'

P value = 0.000221 (t-test), Q value = 0.076

Table S49.  Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 34(17Q11.2) MUTATED 52 68.0 (8.5)
AMP PEAK 34(17Q11.2) WILD-TYPE 390 62.9 (11.4)

Figure S49.  Get High-res Image Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 34(17q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.6e-17 (Chi-square test), Q value = 3.1e-14

Table S50.  Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 34(17Q11.2) MUTATED 14 0 0 0 1 5 32
AMP PEAK 34(17Q11.2) WILD-TYPE 313 3 8 2 6 13 46

Figure S50.  Get High-res Image Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 35(17q12) mutation analysis' versus 'AGE'

P value = 5.99e-05 (t-test), Q value = 0.022

Table S51.  Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 35(17Q12) MUTATED 53 68.8 (9.4)
AMP PEAK 35(17Q12) WILD-TYPE 389 62.8 (11.3)

Figure S51.  Get High-res Image Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 35(17q12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.29e-18 (Chi-square test), Q value = 3.4e-15

Table S52.  Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 35(17Q12) MUTATED 15 0 1 0 0 3 34
AMP PEAK 35(17Q12) WILD-TYPE 312 3 7 2 7 15 44

Figure S52.  Get High-res Image Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 36(17q25.1) mutation analysis' versus 'AGE'

P value = 5.73e-05 (t-test), Q value = 0.021

Table S53.  Gene #36: 'Amp Peak 36(17q25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 36(17Q25.1) MUTATED 74 67.6 (8.8)
AMP PEAK 36(17Q25.1) WILD-TYPE 368 62.7 (11.5)

Figure S53.  Get High-res Image Gene #36: 'Amp Peak 36(17q25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 36(17q25.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.63e-16 (Chi-square test), Q value = 4e-13

Table S54.  Gene #36: 'Amp Peak 36(17q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 36(17Q25.1) MUTATED 27 0 0 0 2 8 37
AMP PEAK 36(17Q25.1) WILD-TYPE 300 3 8 2 5 10 41

Figure S54.  Get High-res Image Gene #36: 'Amp Peak 36(17q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 37(18p11.31) mutation analysis' versus 'AGE'

P value = 0.000145 (t-test), Q value = 0.051

Table S55.  Gene #37: 'Amp Peak 37(18p11.31) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 37(18P11.31) MUTATED 66 67.8 (9.2)
AMP PEAK 37(18P11.31) WILD-TYPE 376 62.8 (11.4)

Figure S55.  Get High-res Image Gene #37: 'Amp Peak 37(18p11.31) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 37(18p11.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.67e-18 (Chi-square test), Q value = 7.9e-16

Table S56.  Gene #37: 'Amp Peak 37(18p11.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 37(18P11.31) MUTATED 22 0 0 0 1 4 39
AMP PEAK 37(18P11.31) WILD-TYPE 305 3 8 2 6 14 39

Figure S56.  Get High-res Image Gene #37: 'Amp Peak 37(18p11.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 38(18q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.55e-13 (Chi-square test), Q value = 2.9e-10

Table S57.  Gene #38: 'Amp Peak 38(18q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 38(18Q11.2) MUTATED 16 0 0 0 1 3 29
AMP PEAK 38(18Q11.2) WILD-TYPE 311 3 8 2 6 15 49

Figure S57.  Get High-res Image Gene #38: 'Amp Peak 38(18q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 39(19p13.2) mutation analysis' versus 'AGE'

P value = 3.81e-11 (t-test), Q value = 1.7e-08

Table S58.  Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 39(19P13.2) MUTATED 69 70.7 (8.4)
AMP PEAK 39(19P13.2) WILD-TYPE 373 62.2 (11.2)

Figure S58.  Get High-res Image Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 39(19p13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.72e-18 (Chi-square test), Q value = 3.2e-15

Table S59.  Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 39(19P13.2) MUTATED 23 0 0 0 1 7 38
AMP PEAK 39(19P13.2) WILD-TYPE 304 3 8 2 6 11 40

Figure S59.  Get High-res Image Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 40(19p13.11) mutation analysis' versus 'AGE'

P value = 1.15e-10 (t-test), Q value = 4.9e-08

Table S60.  Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 40(19P13.11) MUTATED 68 71.0 (9.0)
AMP PEAK 40(19P13.11) WILD-TYPE 374 62.2 (11.1)

Figure S60.  Get High-res Image Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 40(19p13.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.14e-20 (Chi-square test), Q value = 1.5e-17

Table S61.  Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 40(19P13.11) MUTATED 22 0 0 0 0 6 40
AMP PEAK 40(19P13.11) WILD-TYPE 305 3 8 2 7 12 38

Figure S61.  Get High-res Image Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 41(19q12) mutation analysis' versus 'AGE'

P value = 2.8e-10 (t-test), Q value = 1.2e-07

Table S62.  Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 41(19Q12) MUTATED 80 69.5 (8.1)
AMP PEAK 41(19Q12) WILD-TYPE 362 62.2 (11.4)

Figure S62.  Get High-res Image Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 41(19q12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.43e-37 (Chi-square test), Q value = 4.1e-34

Table S63.  Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 41(19Q12) MUTATED 18 0 0 0 0 9 53
AMP PEAK 41(19Q12) WILD-TYPE 309 3 8 2 7 9 25

Figure S63.  Get High-res Image Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 41(19q12) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.000405 (Fisher's exact test), Q value = 0.14

Table S64.  Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients NO YES
ALL 338 105
AMP PEAK 41(19Q12) MUTATED 48 32
AMP PEAK 41(19Q12) WILD-TYPE 290 73

Figure S64.  Get High-res Image Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Amp Peak 42(20p13) mutation analysis' versus 'AGE'

P value = 9.5e-05 (t-test), Q value = 0.034

Table S65.  Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 42(20P13) MUTATED 86 67.9 (11.1)
AMP PEAK 42(20P13) WILD-TYPE 356 62.5 (11.0)

Figure S65.  Get High-res Image Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 42(20p13) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.52e-12 (Chi-square test), Q value = 1.1e-09

Table S66.  Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 42(20P13) MUTATED 41 0 0 1 0 4 40
AMP PEAK 42(20P13) WILD-TYPE 286 3 8 1 7 14 38

Figure S66.  Get High-res Image Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 43(20q11.21) mutation analysis' versus 'AGE'

P value = 1.53e-07 (t-test), Q value = 6.2e-05

Table S67.  Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 43(20Q11.21) MUTATED 106 68.3 (10.0)
AMP PEAK 43(20Q11.21) WILD-TYPE 336 62.0 (11.2)

Figure S67.  Get High-res Image Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 43(20q11.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.65e-23 (Chi-square test), Q value = 7.9e-21

Table S68.  Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 43(20Q11.21) MUTATED 44 0 0 1 0 6 55
AMP PEAK 43(20Q11.21) WILD-TYPE 283 3 8 1 7 12 23

Figure S68.  Get High-res Image Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 44(20q13.12) mutation analysis' versus 'AGE'

P value = 4.41e-08 (t-test), Q value = 1.8e-05

Table S69.  Gene #44: 'Amp Peak 44(20q13.12) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 44(20Q13.12) MUTATED 111 68.5 (10.3)
AMP PEAK 44(20Q13.12) WILD-TYPE 331 61.9 (11.1)

Figure S69.  Get High-res Image Gene #44: 'Amp Peak 44(20q13.12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 44(20q13.12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.8e-19 (Chi-square test), Q value = 8.5e-17

Table S70.  Gene #44: 'Amp Peak 44(20q13.12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 44(20Q13.12) MUTATED 49 0 0 1 1 7 53
AMP PEAK 44(20Q13.12) WILD-TYPE 278 3 8 1 6 11 25

Figure S70.  Get High-res Image Gene #44: 'Amp Peak 44(20q13.12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 45(20q13.33) mutation analysis' versus 'AGE'

P value = 1.72e-07 (t-test), Q value = 7e-05

Table S71.  Gene #45: 'Amp Peak 45(20q13.33) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
AMP PEAK 45(20Q13.33) MUTATED 109 68.3 (10.5)
AMP PEAK 45(20Q13.33) WILD-TYPE 333 62.0 (11.1)

Figure S71.  Get High-res Image Gene #45: 'Amp Peak 45(20q13.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 45(20q13.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.45e-15 (Chi-square test), Q value = 1.1e-12

Table S72.  Gene #45: 'Amp Peak 45(20q13.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 45(20Q13.33) MUTATED 51 0 0 1 2 6 49
AMP PEAK 45(20Q13.33) WILD-TYPE 276 3 8 1 5 12 29

Figure S72.  Get High-res Image Gene #45: 'Amp Peak 45(20q13.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 46(22q12.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.21e-19 (Chi-square test), Q value = 3.4e-16

Table S73.  Gene #46: 'Amp Peak 46(22q12.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
AMP PEAK 46(22Q12.2) MUTATED 9 0 0 0 0 2 30
AMP PEAK 46(22Q12.2) WILD-TYPE 318 3 8 2 7 16 48

Figure S73.  Get High-res Image Gene #46: 'Amp Peak 46(22q12.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 1(1p36.21) mutation analysis' versus 'AGE'

P value = 6.57e-05 (t-test), Q value = 0.024

Table S74.  Gene #49: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 1(1P36.21) MUTATED 53 69.2 (10.2)
DEL PEAK 1(1P36.21) WILD-TYPE 389 62.8 (11.2)

Figure S74.  Get High-res Image Gene #49: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 1(1p36.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.13e-08 (Chi-square test), Q value = 1.3e-05

Table S75.  Gene #49: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 1(1P36.21) MUTATED 23 0 0 0 0 4 26
DEL PEAK 1(1P36.21) WILD-TYPE 304 3 8 2 7 14 52

Figure S75.  Get High-res Image Gene #49: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 2(1p36.11) mutation analysis' versus 'AGE'

P value = 7.28e-05 (t-test), Q value = 0.027

Table S76.  Gene #50: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 2(1P36.11) MUTATED 58 68.5 (9.5)
DEL PEAK 2(1P36.11) WILD-TYPE 384 62.8 (11.3)

Figure S76.  Get High-res Image Gene #50: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 2(1p36.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.44e-12 (Chi-square test), Q value = 3.7e-09

Table S77.  Gene #50: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 2(1P36.11) MUTATED 23 0 0 0 0 4 31
DEL PEAK 2(1P36.11) WILD-TYPE 304 3 8 2 7 14 47

Figure S77.  Get High-res Image Gene #50: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 5(2q22.1) mutation analysis' versus 'Time to Death'

P value = 1.1e-08 (logrank test), Q value = 4.6e-06

Table S78.  Gene #53: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 438 41 0.0 - 187.1 (15.8)
DEL PEAK 5(2Q22.1) MUTATED 34 10 0.1 - 113.2 (7.9)
DEL PEAK 5(2Q22.1) WILD-TYPE 404 31 0.0 - 187.1 (16.6)

Figure S78.  Get High-res Image Gene #53: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Del Peak 5(2q22.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.51e-05 (Chi-square test), Q value = 0.034

Table S79.  Gene #53: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 5(2Q22.1) MUTATED 15 0 0 0 1 1 17
DEL PEAK 5(2Q22.1) WILD-TYPE 312 3 8 2 6 17 61

Figure S79.  Get High-res Image Gene #53: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 6(2q37.3) mutation analysis' versus 'AGE'

P value = 0.000706 (t-test), Q value = 0.23

Table S80.  Gene #54: 'Del Peak 6(2q37.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 6(2Q37.3) MUTATED 38 67.9 (7.5)
DEL PEAK 6(2Q37.3) WILD-TYPE 404 63.1 (11.5)

Figure S80.  Get High-res Image Gene #54: 'Del Peak 6(2q37.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 7(3p14.2) mutation analysis' versus 'AGE'

P value = 2.76e-05 (t-test), Q value = 0.01

Table S81.  Gene #55: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 7(3P14.2) MUTATED 56 67.8 (7.1)
DEL PEAK 7(3P14.2) WILD-TYPE 386 62.9 (11.6)

Figure S81.  Get High-res Image Gene #55: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 7(3p14.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.58e-14 (Chi-square test), Q value = 1.2e-11

Table S82.  Gene #55: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 7(3P14.2) MUTATED 18 0 0 0 1 6 31
DEL PEAK 7(3P14.2) WILD-TYPE 309 3 8 2 6 12 47

Figure S82.  Get High-res Image Gene #55: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 8(3q13.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.18e-05 (Chi-square test), Q value = 0.012

Table S83.  Gene #56: 'Del Peak 8(3q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 8(3Q13.31) MUTATED 7 0 0 0 0 1 13
DEL PEAK 8(3Q13.31) WILD-TYPE 320 3 8 2 7 17 65

Figure S83.  Get High-res Image Gene #56: 'Del Peak 8(3q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 9(4p16.3) mutation analysis' versus 'AGE'

P value = 6.87e-05 (t-test), Q value = 0.025

Table S84.  Gene #57: 'Del Peak 9(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 9(4P16.3) MUTATED 65 68.0 (9.1)
DEL PEAK 9(4P16.3) WILD-TYPE 377 62.8 (11.4)

Figure S84.  Get High-res Image Gene #57: 'Del Peak 9(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 9(4p16.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.17e-13 (Chi-square test), Q value = 2.7e-10

Table S85.  Gene #57: 'Del Peak 9(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 9(4P16.3) MUTATED 25 0 0 0 2 4 34
DEL PEAK 9(4P16.3) WILD-TYPE 302 3 8 2 5 14 44

Figure S85.  Get High-res Image Gene #57: 'Del Peak 9(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 10(4p15.31) mutation analysis' versus 'AGE'

P value = 9.3e-05 (t-test), Q value = 0.034

Table S86.  Gene #58: 'Del Peak 10(4p15.31) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 10(4P15.31) MUTATED 64 68.0 (9.2)
DEL PEAK 10(4P15.31) WILD-TYPE 378 62.8 (11.4)

Figure S86.  Get High-res Image Gene #58: 'Del Peak 10(4p15.31) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 10(4p15.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.54e-12 (Chi-square test), Q value = 3.7e-09

Table S87.  Gene #58: 'Del Peak 10(4p15.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 10(4P15.31) MUTATED 26 0 0 0 2 3 33
DEL PEAK 10(4P15.31) WILD-TYPE 301 3 8 2 5 15 45

Figure S87.  Get High-res Image Gene #58: 'Del Peak 10(4p15.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 11(4q22.1) mutation analysis' versus 'AGE'

P value = 1.31e-05 (t-test), Q value = 0.005

Table S88.  Gene #59: 'Del Peak 11(4q22.1) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 11(4Q22.1) MUTATED 76 68.1 (9.2)
DEL PEAK 11(4Q22.1) WILD-TYPE 366 62.6 (11.4)

Figure S88.  Get High-res Image Gene #59: 'Del Peak 11(4q22.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 11(4q22.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.34e-24 (Chi-square test), Q value = 2.6e-21

Table S89.  Gene #59: 'Del Peak 11(4q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 11(4Q22.1) MUTATED 24 0 0 0 1 5 46
DEL PEAK 11(4Q22.1) WILD-TYPE 303 3 8 2 6 13 32

Figure S89.  Get High-res Image Gene #59: 'Del Peak 11(4q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 12(4q34.3) mutation analysis' versus 'AGE'

P value = 2.13e-05 (t-test), Q value = 0.008

Table S90.  Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 12(4Q34.3) MUTATED 90 67.7 (9.9)
DEL PEAK 12(4Q34.3) WILD-TYPE 352 62.5 (11.3)

Figure S90.  Get High-res Image Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 12(4q34.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.43e-23 (Chi-square test), Q value = 6.9e-21

Table S91.  Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 12(4Q34.3) MUTATED 32 0 0 0 2 6 50
DEL PEAK 12(4Q34.3) WILD-TYPE 295 3 8 2 5 12 28

Figure S91.  Get High-res Image Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 12(4q34.3) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 4.2e-05 (Fisher's exact test), Q value = 0.016

Table S92.  Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients NO YES
ALL 338 105
DEL PEAK 12(4Q34.3) MUTATED 53 37
DEL PEAK 12(4Q34.3) WILD-TYPE 285 68

Figure S92.  Get High-res Image Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Del Peak 13(5q11.2) mutation analysis' versus 'AGE'

P value = 7.58e-05 (t-test), Q value = 0.028

Table S93.  Gene #61: 'Del Peak 13(5q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 13(5Q11.2) MUTATED 76 67.8 (9.6)
DEL PEAK 13(5Q11.2) WILD-TYPE 366 62.7 (11.4)

Figure S93.  Get High-res Image Gene #61: 'Del Peak 13(5q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 13(5q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.75e-23 (Chi-square test), Q value = 2.8e-20

Table S94.  Gene #61: 'Del Peak 13(5q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 13(5Q11.2) MUTATED 27 0 0 0 1 2 46
DEL PEAK 13(5Q11.2) WILD-TYPE 300 3 8 2 6 16 32

Figure S94.  Get High-res Image Gene #61: 'Del Peak 13(5q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 14(6q26) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.63e-09 (Chi-square test), Q value = 3.6e-06

Table S95.  Gene #62: 'Del Peak 14(6q26) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 14(6Q26) MUTATED 10 0 1 0 0 3 20
DEL PEAK 14(6Q26) WILD-TYPE 317 3 7 2 7 15 58

Figure S95.  Get High-res Image Gene #62: 'Del Peak 14(6q26) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 15(7p22.3) mutation analysis' versus 'AGE'

P value = 2.62e-05 (t-test), Q value = 0.0099

Table S96.  Gene #63: 'Del Peak 15(7p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 15(7P22.3) MUTATED 55 68.9 (9.2)
DEL PEAK 15(7P22.3) WILD-TYPE 387 62.8 (11.3)

Figure S96.  Get High-res Image Gene #63: 'Del Peak 15(7p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 15(7p22.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.18e-13 (Chi-square test), Q value = 9.7e-11

Table S97.  Gene #63: 'Del Peak 15(7p22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 15(7P22.3) MUTATED 19 0 0 0 1 5 31
DEL PEAK 15(7P22.3) WILD-TYPE 308 3 8 2 6 13 47

Figure S97.  Get High-res Image Gene #63: 'Del Peak 15(7p22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 16(7q11.22) mutation analysis' versus 'AGE'

P value = 1.91e-05 (t-test), Q value = 0.0072

Table S98.  Gene #64: 'Del Peak 16(7q11.22) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 16(7Q11.22) MUTATED 31 71.0 (8.6)
DEL PEAK 16(7Q11.22) WILD-TYPE 411 63.0 (11.2)

Figure S98.  Get High-res Image Gene #64: 'Del Peak 16(7q11.22) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 16(7q11.22) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.17e-07 (Chi-square test), Q value = 0.00013

Table S99.  Gene #64: 'Del Peak 16(7q11.22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 16(7Q11.22) MUTATED 10 0 0 0 1 2 18
DEL PEAK 16(7Q11.22) WILD-TYPE 317 3 8 2 6 16 60

Figure S99.  Get High-res Image Gene #64: 'Del Peak 16(7q11.22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 17(7q31.1) mutation analysis' versus 'AGE'

P value = 3.24e-06 (t-test), Q value = 0.0013

Table S100.  Gene #65: 'Del Peak 17(7q31.1) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 17(7Q31.1) MUTATED 39 69.9 (7.6)
DEL PEAK 17(7Q31.1) WILD-TYPE 403 62.9 (11.3)

Figure S100.  Get High-res Image Gene #65: 'Del Peak 17(7q31.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 17(7q31.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.01e-17 (Chi-square test), Q value = 4.7e-15

Table S101.  Gene #65: 'Del Peak 17(7q31.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 17(7Q31.1) MUTATED 7 0 0 0 1 3 28
DEL PEAK 17(7Q31.1) WILD-TYPE 320 3 8 2 6 15 50

Figure S101.  Get High-res Image Gene #65: 'Del Peak 17(7q31.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 18(7q36.3) mutation analysis' versus 'AGE'

P value = 3.53e-08 (t-test), Q value = 1.5e-05

Table S102.  Gene #66: 'Del Peak 18(7q36.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 18(7Q36.3) MUTATED 49 70.8 (8.4)
DEL PEAK 18(7Q36.3) WILD-TYPE 393 62.6 (11.2)

Figure S102.  Get High-res Image Gene #66: 'Del Peak 18(7q36.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 18(7q36.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.76e-17 (Chi-square test), Q value = 1.3e-14

Table S103.  Gene #66: 'Del Peak 18(7q36.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 18(7Q36.3) MUTATED 12 0 0 0 1 5 31
DEL PEAK 18(7Q36.3) WILD-TYPE 315 3 8 2 6 13 47

Figure S103.  Get High-res Image Gene #66: 'Del Peak 18(7q36.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 19(8p23.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.72e-25 (Chi-square test), Q value = 1.3e-22

Table S104.  Gene #67: 'Del Peak 19(8p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 19(8P23.2) MUTATED 25 0 0 0 2 4 48
DEL PEAK 19(8P23.2) WILD-TYPE 302 3 8 2 5 14 30

Figure S104.  Get High-res Image Gene #67: 'Del Peak 19(8p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 20(9p23) mutation analysis' versus 'AGE'

P value = 0.000379 (t-test), Q value = 0.13

Table S105.  Gene #68: 'Del Peak 20(9p23) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 20(9P23) MUTATED 50 68.0 (8.5)
DEL PEAK 20(9P23) WILD-TYPE 392 63.0 (11.4)

Figure S105.  Get High-res Image Gene #68: 'Del Peak 20(9p23) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 20(9p23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.75e-10 (Chi-square test), Q value = 2.9e-07

Table S106.  Gene #68: 'Del Peak 20(9p23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 20(9P23) MUTATED 20 0 0 0 0 3 27
DEL PEAK 20(9P23) WILD-TYPE 307 3 8 2 7 15 51

Figure S106.  Get High-res Image Gene #68: 'Del Peak 20(9p23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 21(9q34.11) mutation analysis' versus 'AGE'

P value = 2.55e-10 (t-test), Q value = 1.1e-07

Table S107.  Gene #69: 'Del Peak 21(9q34.11) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 21(9Q34.11) MUTATED 101 69.0 (8.8)
DEL PEAK 21(9Q34.11) WILD-TYPE 341 61.9 (11.4)

Figure S107.  Get High-res Image Gene #69: 'Del Peak 21(9q34.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 21(9q34.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.18e-16 (Chi-square test), Q value = 5.5e-14

Table S108.  Gene #69: 'Del Peak 21(9q34.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 21(9Q34.11) MUTATED 44 0 0 0 2 8 47
DEL PEAK 21(9Q34.11) WILD-TYPE 283 3 8 2 5 10 31

Figure S108.  Get High-res Image Gene #69: 'Del Peak 21(9q34.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 22(10q23.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000137 (Chi-square test), Q value = 0.049

Table S109.  Gene #70: 'Del Peak 22(10q23.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 22(10Q23.31) MUTATED 26 0 0 0 1 3 22
DEL PEAK 22(10Q23.31) WILD-TYPE 301 3 8 2 6 15 56

Figure S109.  Get High-res Image Gene #70: 'Del Peak 22(10q23.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 23(11p15.5) mutation analysis' versus 'AGE'

P value = 2.81e-08 (t-test), Q value = 1.2e-05

Table S110.  Gene #71: 'Del Peak 23(11p15.5) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 23(11P15.5) MUTATED 76 69.2 (8.7)
DEL PEAK 23(11P15.5) WILD-TYPE 366 62.4 (11.4)

Figure S110.  Get High-res Image Gene #71: 'Del Peak 23(11p15.5) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 23(11p15.5) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.03e-21 (Chi-square test), Q value = 4.9e-19

Table S111.  Gene #71: 'Del Peak 23(11p15.5) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 23(11P15.5) MUTATED 25 0 0 0 1 6 44
DEL PEAK 23(11P15.5) WILD-TYPE 302 3 8 2 6 12 34

Figure S111.  Get High-res Image Gene #71: 'Del Peak 23(11p15.5) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 24(11q14.1) mutation analysis' versus 'AGE'

P value = 1.04e-05 (t-test), Q value = 0.004

Table S112.  Gene #72: 'Del Peak 24(11q14.1) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 24(11Q14.1) MUTATED 50 69.1 (8.5)
DEL PEAK 24(11Q14.1) WILD-TYPE 392 62.8 (11.4)

Figure S112.  Get High-res Image Gene #72: 'Del Peak 24(11q14.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 24(11q14.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.73e-13 (Chi-square test), Q value = 7.7e-11

Table S113.  Gene #72: 'Del Peak 24(11q14.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 24(11Q14.1) MUTATED 16 0 0 0 0 6 28
DEL PEAK 24(11Q14.1) WILD-TYPE 311 3 8 2 7 12 50

Figure S113.  Get High-res Image Gene #72: 'Del Peak 24(11q14.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 25(11q25) mutation analysis' versus 'AGE'

P value = 8.41e-05 (t-test), Q value = 0.031

Table S114.  Gene #73: 'Del Peak 25(11q25) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 25(11Q25) MUTATED 68 68.1 (9.9)
DEL PEAK 25(11Q25) WILD-TYPE 374 62.7 (11.3)

Figure S114.  Get High-res Image Gene #73: 'Del Peak 25(11q25) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 25(11q25) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.19e-14 (Chi-square test), Q value = 1.4e-11

Table S115.  Gene #73: 'Del Peak 25(11q25) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 25(11Q25) MUTATED 27 0 0 0 0 5 36
DEL PEAK 25(11Q25) WILD-TYPE 300 3 8 2 7 13 42

Figure S115.  Get High-res Image Gene #73: 'Del Peak 25(11q25) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 26(12q23.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.45e-11 (Chi-square test), Q value = 2.4e-08

Table S116.  Gene #74: 'Del Peak 26(12q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 26(12Q23.1) MUTATED 10 0 0 0 0 1 22
DEL PEAK 26(12Q23.1) WILD-TYPE 317 3 8 2 7 17 56

Figure S116.  Get High-res Image Gene #74: 'Del Peak 26(12q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 27(12q24.33) mutation analysis' versus 'AGE'

P value = 0.000113 (t-test), Q value = 0.041

Table S117.  Gene #75: 'Del Peak 27(12q24.33) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 27(12Q24.33) MUTATED 43 68.9 (8.7)
DEL PEAK 27(12Q24.33) WILD-TYPE 399 63.0 (11.3)

Figure S117.  Get High-res Image Gene #75: 'Del Peak 27(12q24.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 27(12q24.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.79e-14 (Chi-square test), Q value = 2.1e-11

Table S118.  Gene #75: 'Del Peak 27(12q24.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 27(12Q24.33) MUTATED 14 0 0 0 0 1 28
DEL PEAK 27(12Q24.33) WILD-TYPE 313 3 8 2 7 17 50

Figure S118.  Get High-res Image Gene #75: 'Del Peak 27(12q24.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 28(13q11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.11e-09 (Chi-square test), Q value = 4.7e-07

Table S119.  Gene #76: 'Del Peak 28(13q11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 28(13Q11) MUTATED 30 0 0 0 2 3 32
DEL PEAK 28(13Q11) WILD-TYPE 297 3 8 2 5 15 46

Figure S119.  Get High-res Image Gene #76: 'Del Peak 28(13q11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 29(13q14.2) mutation analysis' versus 'AGE'

P value = 0.000606 (t-test), Q value = 0.2

Table S120.  Gene #77: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 29(13Q14.2) MUTATED 71 67.3 (9.4)
DEL PEAK 29(13Q14.2) WILD-TYPE 371 62.8 (11.4)

Figure S120.  Get High-res Image Gene #77: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 29(13q14.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000306 (Chi-square test), Q value = 0.1

Table S121.  Gene #77: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 29(13Q14.2) MUTATED 39 0 0 0 2 4 26
DEL PEAK 29(13Q14.2) WILD-TYPE 288 3 8 2 5 14 52

Figure S121.  Get High-res Image Gene #77: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 30(14q13.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.18e-12 (Chi-square test), Q value = 3.6e-09

Table S122.  Gene #78: 'Del Peak 30(14q13.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 30(14Q13.1) MUTATED 20 0 0 0 0 5 29
DEL PEAK 30(14Q13.1) WILD-TYPE 307 3 8 2 7 13 49

Figure S122.  Get High-res Image Gene #78: 'Del Peak 30(14q13.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 31(15q15.1) mutation analysis' versus 'AGE'

P value = 1.54e-08 (t-test), Q value = 6.4e-06

Table S123.  Gene #79: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 31(15Q15.1) MUTATED 102 68.6 (9.5)
DEL PEAK 31(15Q15.1) WILD-TYPE 340 62.0 (11.3)

Figure S123.  Get High-res Image Gene #79: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 31(15q15.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.67e-20 (Chi-square test), Q value = 1.3e-17

Table S124.  Gene #79: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 31(15Q15.1) MUTATED 42 0 0 0 2 7 51
DEL PEAK 31(15Q15.1) WILD-TYPE 285 3 8 2 5 11 27

Figure S124.  Get High-res Image Gene #79: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 32(15q23) mutation analysis' versus 'AGE'

P value = 8.73e-06 (t-test), Q value = 0.0034

Table S125.  Gene #80: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 32(15Q23) MUTATED 82 68.1 (9.4)
DEL PEAK 32(15Q23) WILD-TYPE 360 62.5 (11.4)

Figure S125.  Get High-res Image Gene #80: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 32(15q23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.75e-20 (Chi-square test), Q value = 3.2e-17

Table S126.  Gene #80: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 32(15Q23) MUTATED 30 0 0 0 2 5 45
DEL PEAK 32(15Q23) WILD-TYPE 297 3 8 2 5 13 33

Figure S126.  Get High-res Image Gene #80: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 33(16p13.3) mutation analysis' versus 'AGE'

P value = 2.74e-08 (t-test), Q value = 1.1e-05

Table S127.  Gene #81: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 33(16P13.3) MUTATED 61 69.5 (7.8)
DEL PEAK 33(16P13.3) WILD-TYPE 381 62.6 (11.4)

Figure S127.  Get High-res Image Gene #81: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 33(16p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.77e-15 (Chi-square test), Q value = 8.1e-13

Table S128.  Gene #81: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 33(16P13.3) MUTATED 22 0 0 0 0 4 35
DEL PEAK 33(16P13.3) WILD-TYPE 305 3 8 2 7 14 43

Figure S128.  Get High-res Image Gene #81: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 34(16q21) mutation analysis' versus 'AGE'

P value = 1.51e-08 (t-test), Q value = 6.3e-06

Table S129.  Gene #82: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 34(16Q21) MUTATED 116 68.1 (9.1)
DEL PEAK 34(16Q21) WILD-TYPE 326 61.9 (11.5)

Figure S129.  Get High-res Image Gene #82: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 34(16q21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.27e-21 (Chi-square test), Q value = 2e-18

Table S130.  Gene #82: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 34(16Q21) MUTATED 52 0 0 0 1 7 56
DEL PEAK 34(16Q21) WILD-TYPE 275 3 8 2 6 11 22

Figure S130.  Get High-res Image Gene #82: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 35(16q23.1) mutation analysis' versus 'AGE'

P value = 1e-07 (t-test), Q value = 4.1e-05

Table S131.  Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 35(16Q23.1) MUTATED 126 67.7 (9.3)
DEL PEAK 35(16Q23.1) WILD-TYPE 316 61.9 (11.5)

Figure S131.  Get High-res Image Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 35(16q23.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.19e-24 (Chi-square test), Q value = 5.8e-22

Table S132.  Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 35(16Q23.1) MUTATED 57 0 0 0 1 6 62
DEL PEAK 35(16Q23.1) WILD-TYPE 270 3 8 2 6 12 16

Figure S132.  Get High-res Image Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 35(16q23.1) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 3e-04 (Fisher's exact test), Q value = 0.1

Table S133.  Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients NO YES
ALL 338 105
DEL PEAK 35(16Q23.1) MUTATED 81 45
DEL PEAK 35(16Q23.1) WILD-TYPE 257 60

Figure S133.  Get High-res Image Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Del Peak 36(17p13.3) mutation analysis' versus 'AGE'

P value = 4.09e-05 (t-test), Q value = 0.015

Table S134.  Gene #84: 'Del Peak 36(17p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 36(17P13.3) MUTATED 84 67.5 (9.2)
DEL PEAK 36(17P13.3) WILD-TYPE 358 62.6 (11.5)

Figure S134.  Get High-res Image Gene #84: 'Del Peak 36(17p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 36(17p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.11e-16 (Chi-square test), Q value = 1.4e-13

Table S135.  Gene #84: 'Del Peak 36(17p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 36(17P13.3) MUTATED 33 0 0 0 2 8 41
DEL PEAK 36(17P13.3) WILD-TYPE 294 3 8 2 5 10 37

Figure S135.  Get High-res Image Gene #84: 'Del Peak 36(17p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 37(17p12) mutation analysis' versus 'AGE'

P value = 3.09e-07 (t-test), Q value = 0.00012

Table S136.  Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 37(17P12) MUTATED 96 68.1 (8.9)
DEL PEAK 37(17P12) WILD-TYPE 346 62.3 (11.5)

Figure S136.  Get High-res Image Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 37(17p12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.12e-24 (Chi-square test), Q value = 5.5e-22

Table S137.  Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 37(17P12) MUTATED 35 0 0 0 1 8 52
DEL PEAK 37(17P12) WILD-TYPE 292 3 8 2 6 10 26

Figure S137.  Get High-res Image Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 37(17p12) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.000622 (Fisher's exact test), Q value = 0.21

Table S138.  Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients NO YES
ALL 338 105
DEL PEAK 37(17P12) MUTATED 60 36
DEL PEAK 37(17P12) WILD-TYPE 278 69

Figure S138.  Get High-res Image Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Del Peak 38(17p11.2) mutation analysis' versus 'AGE'

P value = 3.63e-06 (t-test), Q value = 0.0014

Table S139.  Gene #86: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 38(17P11.2) MUTATED 87 68.0 (9.1)
DEL PEAK 38(17P11.2) WILD-TYPE 355 62.5 (11.5)

Figure S139.  Get High-res Image Gene #86: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 38(17p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.97e-17 (Chi-square test), Q value = 9.2e-15

Table S140.  Gene #86: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 38(17P11.2) MUTATED 35 0 0 0 1 7 44
DEL PEAK 38(17P11.2) WILD-TYPE 292 3 8 2 6 11 34

Figure S140.  Get High-res Image Gene #86: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 39(17q11.2) mutation analysis' versus 'AGE'

P value = 1.6e-05 (t-test), Q value = 0.0061

Table S141.  Gene #87: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 39(17Q11.2) MUTATED 77 68.0 (9.1)
DEL PEAK 39(17Q11.2) WILD-TYPE 365 62.6 (11.4)

Figure S141.  Get High-res Image Gene #87: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 39(17q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.05e-10 (Chi-square test), Q value = 1.3e-07

Table S142.  Gene #87: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 39(17Q11.2) MUTATED 35 0 0 0 2 5 35
DEL PEAK 39(17Q11.2) WILD-TYPE 292 3 8 2 5 13 43

Figure S142.  Get High-res Image Gene #87: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 40(17q21.2) mutation analysis' versus 'AGE'

P value = 2.13e-05 (t-test), Q value = 0.008

Table S143.  Gene #88: 'Del Peak 40(17q21.2) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 40(17Q21.2) MUTATED 82 67.9 (9.5)
DEL PEAK 40(17Q21.2) WILD-TYPE 360 62.6 (11.4)

Figure S143.  Get High-res Image Gene #88: 'Del Peak 40(17q21.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 40(17q21.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.08e-14 (Chi-square test), Q value = 2.3e-11

Table S144.  Gene #88: 'Del Peak 40(17q21.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 40(17Q21.2) MUTATED 35 0 0 0 1 6 40
DEL PEAK 40(17Q21.2) WILD-TYPE 292 3 8 2 6 12 38

Figure S144.  Get High-res Image Gene #88: 'Del Peak 40(17q21.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 41(18q23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.41e-15 (Chi-square test), Q value = 2.9e-12

Table S145.  Gene #89: 'Del Peak 41(18q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 41(18Q23) MUTATED 28 0 0 0 2 5 38
DEL PEAK 41(18Q23) WILD-TYPE 299 3 8 2 5 13 40

Figure S145.  Get High-res Image Gene #89: 'Del Peak 41(18q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 42(19p13.3) mutation analysis' versus 'AGE'

P value = 5.3e-12 (t-test), Q value = 2.3e-09

Table S146.  Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 42(19P13.3) MUTATED 115 69.0 (8.7)
DEL PEAK 42(19P13.3) WILD-TYPE 327 61.6 (11.4)

Figure S146.  Get High-res Image Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 42(19p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.23e-44 (Chi-square test), Q value = 6e-42

Table S147.  Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 42(19P13.3) MUTATED 35 0 0 0 1 8 71
DEL PEAK 42(19P13.3) WILD-TYPE 292 3 8 2 6 10 7

Figure S147.  Get High-res Image Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 42(19p13.3) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.00032 (Fisher's exact test), Q value = 0.11

Table S148.  Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients NO YES
ALL 338 105
DEL PEAK 42(19P13.3) MUTATED 73 42
DEL PEAK 42(19P13.3) WILD-TYPE 265 63

Figure S148.  Get High-res Image Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Del Peak 43(19p12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.16e-07 (Chi-square test), Q value = 0.00021

Table S149.  Gene #91: 'Del Peak 43(19p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 43(19P12) MUTATED 13 0 0 0 2 4 18
DEL PEAK 43(19P12) WILD-TYPE 314 3 8 2 5 14 60

Figure S149.  Get High-res Image Gene #91: 'Del Peak 43(19p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 44(19q13.43) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.63e-14 (Chi-square test), Q value = 7.4e-12

Table S150.  Gene #92: 'Del Peak 44(19q13.43) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 44(19Q13.43) MUTATED 14 0 0 0 0 4 29
DEL PEAK 44(19Q13.43) WILD-TYPE 313 3 8 2 7 14 49

Figure S150.  Get High-res Image Gene #92: 'Del Peak 44(19q13.43) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 46(22q11.1) mutation analysis' versus 'AGE'

P value = 4.63e-05 (t-test), Q value = 0.017

Table S151.  Gene #94: 'Del Peak 46(22q11.1) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 46(22Q11.1) MUTATED 65 68.0 (8.8)
DEL PEAK 46(22Q11.1) WILD-TYPE 377 62.8 (11.4)

Figure S151.  Get High-res Image Gene #94: 'Del Peak 46(22q11.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 46(22q11.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000195 (Chi-square test), Q value = 0.068

Table S152.  Gene #94: 'Del Peak 46(22q11.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 46(22Q11.1) MUTATED 35 0 0 0 2 3 25
DEL PEAK 46(22Q11.1) WILD-TYPE 292 3 8 2 5 15 53

Figure S152.  Get High-res Image Gene #94: 'Del Peak 46(22q11.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 47(22q12.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.78e-05 (Chi-square test), Q value = 0.014

Table S153.  Gene #95: 'Del Peak 47(22q12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 47(22Q12.1) MUTATED 37 0 0 0 1 7 25
DEL PEAK 47(22Q12.1) WILD-TYPE 290 3 8 2 6 11 53

Figure S153.  Get High-res Image Gene #95: 'Del Peak 47(22q12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 48(22q13.31) mutation analysis' versus 'AGE'

P value = 1.78e-08 (t-test), Q value = 7.4e-06

Table S154.  Gene #96: 'Del Peak 48(22q13.31) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 48(22Q13.31) MUTATED 99 68.7 (9.4)
DEL PEAK 48(22Q13.31) WILD-TYPE 343 62.1 (11.3)

Figure S154.  Get High-res Image Gene #96: 'Del Peak 48(22q13.31) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 48(22q13.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.75e-16 (Chi-square test), Q value = 8.1e-14

Table S155.  Gene #96: 'Del Peak 48(22q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 48(22Q13.31) MUTATED 44 0 0 0 1 7 47
DEL PEAK 48(22Q13.31) WILD-TYPE 283 3 8 2 6 11 31

Figure S155.  Get High-res Image Gene #96: 'Del Peak 48(22q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 49(22q13.32) mutation analysis' versus 'AGE'

P value = 4.1e-07 (t-test), Q value = 0.00016

Table S156.  Gene #97: 'Del Peak 49(22q13.32) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 49(22Q13.32) MUTATED 105 68.2 (10.1)
DEL PEAK 49(22Q13.32) WILD-TYPE 337 62.1 (11.2)

Figure S156.  Get High-res Image Gene #97: 'Del Peak 49(22q13.32) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 49(22q13.32) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.5e-17 (Chi-square test), Q value = 1.2e-14

Table S157.  Gene #97: 'Del Peak 49(22q13.32) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 49(22Q13.32) MUTATED 47 0 0 0 1 8 49
DEL PEAK 49(22Q13.32) WILD-TYPE 280 3 8 2 6 10 29

Figure S157.  Get High-res Image Gene #97: 'Del Peak 49(22q13.32) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 50(Xp21.1) mutation analysis' versus 'AGE'

P value = 0.000137 (t-test), Q value = 0.049

Table S158.  Gene #98: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 442 63.5 (11.2)
DEL PEAK 50(XP21.1) MUTATED 62 67.8 (8.8)
DEL PEAK 50(XP21.1) WILD-TYPE 380 62.8 (11.5)

Figure S158.  Get High-res Image Gene #98: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 50(Xp21.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.19e-13 (Chi-square test), Q value = 1.9e-10

Table S159.  Gene #98: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 327 3 8 2 7 18 78
DEL PEAK 50(XP21.1) MUTATED 25 0 0 0 1 2 34
DEL PEAK 50(XP21.1) WILD-TYPE 302 3 8 2 6 16 44

Figure S159.  Get High-res Image Gene #98: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

Methods & Data
Input

  • Copy number data file = All Lesions File (all_lesions.conf_##.txt, where ## is the confidence level). The all lesions file is from GISTIC pipeline and summarizes the results from the GISTIC run. It contains data about the significant regions of amplification and deletion as well as which samples are amplified or deleted in each of these regions. The identified regions are listed down the first column, and the samples are listed across the first row, starting in column 10.

  • Clinical data file = UCEC.clin.merged.picked.txt

  • Number of patients = 443

  • Number of copy number variation regions = 98

  • Number of selected clinical features = 5

  • Exclude regions that fewer than K tumors have alterations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene cnvs were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene cnvs using 't.test' function in R

Chi-square test

For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)
[3] Greenwood and Nikulin, A guide to chi-squared testing, Wiley, New York. ISBN 047155779X (1996)
[4] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[5] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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