This pipeline computes the correlation between significant arm-level copy number variations (cnvs) and selected clinical features.
Testing the association between subtypes identified by 80 different clustering approaches and 21 clinical features across 4563 patients, 329 significant findings detected with Q value < 0.25.
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2 subtypes identified in current cancer cohort by '1p gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', and 'PATHOLOGY.T'.
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2 subtypes identified in current cancer cohort by '1q gain mutation analysis'. These subtypes correlate to 'Time to Death', 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', and 'PATHOLOGY.T'.
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2 subtypes identified in current cancer cohort by '2p gain mutation analysis'. These subtypes correlate to 'AGE', 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'RADIATIONS.RADIATION.REGIMENINDICATION', and 'NEOPLASM.DISEASESTAGE'.
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2 subtypes identified in current cancer cohort by '2q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '3p gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'TUMOR.STAGE', and 'NEOPLASM.DISEASESTAGE'.
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2 subtypes identified in current cancer cohort by '3q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'KARNOFSKY.PERFORMANCE.SCORE', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'PATHOLOGY.N', 'TUMOR.STAGE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '4p gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '4q gain mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by '5p gain mutation analysis'. These subtypes correlate to 'AGE', 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '5q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '6p gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '6q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '7p gain mutation analysis'. These subtypes correlate to 'Time to Death', 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'PATHOLOGICSPREAD(M)', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '7q gain mutation analysis'. These subtypes correlate to 'Time to Death', 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'PATHOLOGICSPREAD(M)', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '8p gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'PATHOLOGY.T'.
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2 subtypes identified in current cancer cohort by '8q gain mutation analysis'. These subtypes correlate to 'Time to Death', 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'PATHOLOGY.N', 'TUMOR.STAGE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '9p gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'PATHOLOGY.T'.
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2 subtypes identified in current cancer cohort by '9q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '10p gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'TUMOR.STAGE', and 'TOBACCOSMOKINGHISTORYINDICATOR'.
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2 subtypes identified in current cancer cohort by '10q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '11p gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '11q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'STOPPEDSMOKINGYEAR'.
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2 subtypes identified in current cancer cohort by '12p gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'TUMOR.STAGE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '12q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '13q gain mutation analysis'. These subtypes correlate to 'AGE', 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'PATHOLOGY.N', 'PATHOLOGICSPREAD(M)', 'TUMOR.STAGE', 'RADIATIONS.RADIATION.REGIMENINDICATION', 'TOBACCOSMOKINGHISTORYINDICATOR', and 'COMPLETENESS.OF.RESECTION'.
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2 subtypes identified in current cancer cohort by '14q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '15q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'PATHOLOGY.T'.
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2 subtypes identified in current cancer cohort by '16p gain mutation analysis'. These subtypes correlate to 'Time to Death', 'PRIMARY.SITE.OF.DISEASE', 'GENDER', and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '16q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '17p gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '17q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '18p gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '18q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'PATHOLOGY.T'.
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2 subtypes identified in current cancer cohort by '19p gain mutation analysis'. These subtypes correlate to 'Time to Death', 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '19q gain mutation analysis'. These subtypes correlate to 'Time to Death', 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '20p gain mutation analysis'. These subtypes correlate to 'Time to Death', 'AGE', 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'PATHOLOGICSPREAD(M)', 'TUMOR.STAGE', and 'COMPLETENESS.OF.RESECTION'.
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2 subtypes identified in current cancer cohort by '20q gain mutation analysis'. These subtypes correlate to 'AGE', 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'TUMOR.STAGE', 'TOBACCOSMOKINGHISTORYINDICATOR', and 'COMPLETENESS.OF.RESECTION'.
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2 subtypes identified in current cancer cohort by '21q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'TOBACCOSMOKINGHISTORYINDICATOR'.
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2 subtypes identified in current cancer cohort by '22q gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', and 'PATHOLOGY.T'.
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2 subtypes identified in current cancer cohort by 'Xq gain mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE'.
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2 subtypes identified in current cancer cohort by '1p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'NEOPLASM.DISEASESTAGE'.
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2 subtypes identified in current cancer cohort by '1q loss mutation analysis'. These subtypes do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by '2p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'GENDER'.
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2 subtypes identified in current cancer cohort by '2q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'TOBACCOSMOKINGHISTORYINDICATOR'.
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2 subtypes identified in current cancer cohort by '3p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'PATHOLOGICSPREAD(M)', 'TUMOR.STAGE', 'RADIATIONS.RADIATION.REGIMENINDICATION', and 'TOBACCOSMOKINGHISTORYINDICATOR'.
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2 subtypes identified in current cancer cohort by '3q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '4p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.N', 'TUMOR.STAGE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '4q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'TUMOR.STAGE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '5p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '5q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '6p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '6q loss mutation analysis'. These subtypes correlate to 'AGE', 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '7p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '7q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', and 'PATHOLOGY.T'.
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2 subtypes identified in current cancer cohort by '8p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'TUMOR.STAGE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '8q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '9p loss mutation analysis'. These subtypes correlate to 'Time to Death', 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'PATHOLOGY.T'.
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2 subtypes identified in current cancer cohort by '9q loss mutation analysis'. These subtypes correlate to 'Time to Death', 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '10p loss mutation analysis'. These subtypes correlate to 'Time to Death', 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '10q loss mutation analysis'. These subtypes correlate to 'Time to Death', 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '11p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.N', 'TUMOR.STAGE', and 'TOBACCOSMOKINGHISTORYINDICATOR'.
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2 subtypes identified in current cancer cohort by '11q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '12p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '12q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '13q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '14q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'PATHOLOGY.N', and 'PATHOLOGICSPREAD(M)'.
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2 subtypes identified in current cancer cohort by '15q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '16p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'TUMOR.STAGE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '16q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'TUMOR.STAGE', 'COMPLETENESS.OF.RESECTION', and 'NEOPLASM.DISEASESTAGE'.
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2 subtypes identified in current cancer cohort by '17p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'TUMOR.STAGE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '17q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', 'TUMOR.STAGE', 'RADIATIONS.RADIATION.REGIMENINDICATION', and 'COMPLETENESS.OF.RESECTION'.
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2 subtypes identified in current cancer cohort by '18p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'PATHOLOGICSPREAD(M)', 'TUMOR.STAGE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '18q loss mutation analysis'. These subtypes correlate to 'AGE', 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'PATHOLOGY.N', 'PATHOLOGICSPREAD(M)', 'TUMOR.STAGE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '19p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'PATHOLOGY.T', 'TUMOR.STAGE', and 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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2 subtypes identified in current cancer cohort by '19q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by '20p loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '20q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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2 subtypes identified in current cancer cohort by '21q loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'HISTOLOGICAL.TYPE', 'TUMOR.STAGE', 'RADIATIONS.RADIATION.REGIMENINDICATION', and 'STOPPEDSMOKINGYEAR'.
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2 subtypes identified in current cancer cohort by '22q loss mutation analysis'. These subtypes correlate to 'Time to Death', 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', and 'TUMOR.STAGE'.
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2 subtypes identified in current cancer cohort by 'Xq loss mutation analysis'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'GENDER', 'HISTOLOGICAL.TYPE', and 'TUMOR.STAGE'.
Clinical Features |
Time to Death |
AGE |
PRIMARY SITE OF DISEASE |
GENDER |
KARNOFSKY PERFORMANCE SCORE |
HISTOLOGICAL TYPE |
PATHOLOGY T |
PATHOLOGY N |
PATHOLOGICSPREAD(M) |
TUMOR STAGE |
RADIATIONS RADIATION REGIMENINDICATION |
NUMBERPACKYEARSSMOKED | STOPPEDSMOKINGYEAR | TOBACCOSMOKINGHISTORYINDICATOR | YEAROFTOBACCOSMOKINGONSET |
DISTANT METASTASIS |
LYMPH NODE METASTASIS |
COMPLETENESS OF RESECTION |
NUMBER OF LYMPH NODES |
TUMOR STAGECODE |
NEOPLASM DISEASESTAGE |
Statistical Tests | logrank test | t-test | Chi-square test | Fisher's exact test | t-test | Chi-square test | Chi-square test | Chi-square test | Chi-square test | Chi-square test | Fisher's exact test | t-test | t-test | Chi-square test | t-test | Chi-square test | Chi-square test | Chi-square test | t-test | t-test | Chi-square test |
1p gain |
0.212 (1.00) |
0.0112 (1.00) |
1.5e-28 (2.24e-25) |
8.6e-07 (0.00116) |
0.457 (1.00) |
1.45e-29 (2.17e-26) |
0.000161 (0.205) |
0.0519 (1.00) |
0.253 (1.00) |
0.312 (1.00) |
0.568 (1.00) |
0.674 (1.00) |
0.726 (1.00) |
0.389 (1.00) |
0.669 (1.00) |
0.935 (1.00) |
0.915 (1.00) |
0.0161 (1.00) |
0.545 (1.00) |
0.315 (1.00) |
|
1q gain |
2.04e-10 (2.88e-07) |
0.841 (1.00) |
3.09e-135 (4.86e-132) |
1.89e-33 (2.85e-30) |
0.692 (1.00) |
2.19e-39 (3.33e-36) |
1.65e-05 (0.0217) |
0.329 (1.00) |
0.000871 (1.00) |
0.329 (1.00) |
0.965 (1.00) |
0.151 (1.00) |
0.304 (1.00) |
0.219 (1.00) |
0.71 (1.00) |
0.533 (1.00) |
0.37 (1.00) |
0.328 (1.00) |
0.229 (1.00) |
0.000266 (0.335) |
|
2p gain |
0.868 (1.00) |
0.000113 (0.145) |
1.25e-30 (1.88e-27) |
0.663 (1.00) |
0.011 (1.00) |
1.8e-13 (2.57e-10) |
0.0316 (1.00) |
0.0328 (1.00) |
0.845 (1.00) |
0.000208 (0.264) |
6.7e-06 (0.0089) |
0.596 (1.00) |
0.0145 (1.00) |
0.00544 (1.00) |
0.285 (1.00) |
0.576 (1.00) |
0.385 (1.00) |
0.868 (1.00) |
0.622 (1.00) |
2.47e-05 (0.0322) |
|
2q gain |
0.877 (1.00) |
0.000858 (1.00) |
1.17e-21 (1.73e-18) |
0.479 (1.00) |
0.785 (1.00) |
1e-08 (1.4e-05) |
0.186 (1.00) |
0.101 (1.00) |
0.627 (1.00) |
0.00618 (1.00) |
0.00163 (1.00) |
0.62 (1.00) |
0.119 (1.00) |
0.0754 (1.00) |
0.297 (1.00) |
0.501 (1.00) |
0.184 (1.00) |
0.82 (1.00) |
0.382 (1.00) |
0.0136 (1.00) |
|
3p gain |
0.489 (1.00) |
0.0841 (1.00) |
2.71e-30 (4.06e-27) |
0.0798 (1.00) |
0.0182 (1.00) |
6.17e-19 (9e-16) |
0.071 (1.00) |
0.336 (1.00) |
0.104 (1.00) |
7.88e-05 (0.101) |
0.0472 (1.00) |
0.817 (1.00) |
0.0811 (1.00) |
0.00405 (1.00) |
0.153 (1.00) |
0.504 (1.00) |
0.064 (1.00) |
0.0182 (1.00) |
0.587 (1.00) |
4.65e-05 (0.0604) |
|
3q gain |
0.152 (1.00) |
0.000438 (0.55) |
2.2e-87 (3.45e-84) |
0.837 (1.00) |
1.53e-05 (0.0201) |
1.25e-88 (1.97e-85) |
6.96e-07 (0.000944) |
9.15e-06 (0.0121) |
0.155 (1.00) |
1.34e-06 (0.00179) |
0.00013 (0.166) |
0.242 (1.00) |
0.0631 (1.00) |
0.818 (1.00) |
0.897 (1.00) |
0.407 (1.00) |
0.0233 (1.00) |
0.0631 (1.00) |
0.194 (1.00) |
0.000658 (0.82) |
|
4p gain |
0.244 (1.00) |
0.282 (1.00) |
1.01e-06 (0.00136) |
0.493 (1.00) |
0.0377 (1.00) |
1.31e-06 (0.00176) |
0.204 (1.00) |
0.924 (1.00) |
0.647 (1.00) |
0.277 (1.00) |
0.391 (1.00) |
0.971 (1.00) |
0.792 (1.00) |
0.508 (1.00) |
0.447 (1.00) |
0.258 (1.00) |
0.844 (1.00) |
0.388 (1.00) |
0.0778 (1.00) |
0.00579 (1.00) |
|
4q gain |
0.525 (1.00) |
0.364 (1.00) |
0.0341 (1.00) |
0.917 (1.00) |
0.476 (1.00) |
0.00527 (1.00) |
0.492 (1.00) |
0.962 (1.00) |
0.93 (1.00) |
0.275 (1.00) |
0.795 (1.00) |
0.748 (1.00) |
0.811 (1.00) |
0.266 (1.00) |
0.897 (1.00) |
0.378 (1.00) |
0.823 (1.00) |
0.296 (1.00) |
0.281 (1.00) |
0.0106 (1.00) |
|
5p gain |
0.317 (1.00) |
3.72e-05 (0.0484) |
7.92e-83 (1.24e-79) |
0.000467 (0.585) |
0.00649 (1.00) |
1.28e-52 (1.97e-49) |
8.46e-10 (1.19e-06) |
0.577 (1.00) |
0.191 (1.00) |
0.0171 (1.00) |
1.41e-08 (1.95e-05) |
0.511 (1.00) |
0.0706 (1.00) |
0.0157 (1.00) |
0.714 (1.00) |
0.732 (1.00) |
0.0942 (1.00) |
0.284 (1.00) |
0.726 (1.00) |
0.534 (1.00) |
|
5q gain |
0.00257 (1.00) |
0.00147 (1.00) |
9.05e-58 (1.4e-54) |
0.000301 (0.379) |
0.414 (1.00) |
4.57e-43 (6.96e-40) |
0.00575 (1.00) |
0.02 (1.00) |
0.0609 (1.00) |
0.00257 (1.00) |
0.00743 (1.00) |
0.863 (1.00) |
0.585 (1.00) |
0.764 (1.00) |
0.119 (1.00) |
0.214 (1.00) |
0.64 (1.00) |
0.368 (1.00) |
0.322 (1.00) |
0.938 (1.00) |
|
6p gain |
0.00365 (1.00) |
0.249 (1.00) |
1.08e-35 (1.63e-32) |
3.41e-07 (0.000465) |
0.444 (1.00) |
4.48e-22 (6.6e-19) |
0.114 (1.00) |
0.0261 (1.00) |
0.00247 (1.00) |
6.63e-07 (0.000899) |
0.00161 (1.00) |
0.783 (1.00) |
0.321 (1.00) |
0.76 (1.00) |
0.356 (1.00) |
0.706 (1.00) |
0.917 (1.00) |
0.0914 (1.00) |
0.418 (1.00) |
0.661 (1.00) |
|
6q gain |
0.0491 (1.00) |
0.0776 (1.00) |
1.31e-18 (1.9e-15) |
0.000741 (0.919) |
0.744 (1.00) |
2.41e-13 (3.44e-10) |
6.68e-05 (0.0861) |
0.129 (1.00) |
0.111 (1.00) |
1.85e-05 (0.0243) |
0.00972 (1.00) |
0.338 (1.00) |
0.793 (1.00) |
0.26 (1.00) |
0.249 (1.00) |
0.459 (1.00) |
0.601 (1.00) |
0.00978 (1.00) |
0.648 (1.00) |
0.697 (1.00) |
|
7p gain |
0 (0) |
0.0159 (1.00) |
1.14e-166 (1.8e-163) |
6.39e-27 (9.51e-24) |
0.148 (1.00) |
1.01e-51 (1.55e-48) |
1.49e-09 (2.09e-06) |
0.00457 (1.00) |
7.41e-05 (0.0954) |
0.204 (1.00) |
6.56e-14 (9.4e-11) |
0.75 (1.00) |
0.567 (1.00) |
0.92 (1.00) |
0.334 (1.00) |
0.539 (1.00) |
0.262 (1.00) |
0.00611 (1.00) |
0.0724 (1.00) |
0.44 (1.00) |
|
7q gain |
0 (0) |
0.106 (1.00) |
1.26e-182 (2e-179) |
8.98e-27 (1.33e-23) |
0.0433 (1.00) |
1.03e-38 (1.56e-35) |
1.08e-08 (1.5e-05) |
0.134 (1.00) |
9.32e-07 (0.00126) |
0.0824 (1.00) |
3.79e-17 (5.51e-14) |
0.372 (1.00) |
0.267 (1.00) |
0.618 (1.00) |
0.692 (1.00) |
0.0909 (1.00) |
0.164 (1.00) |
0.00826 (1.00) |
0.394 (1.00) |
0.265 (1.00) |
|
8p gain |
0.00356 (1.00) |
0.593 (1.00) |
4.18e-25 (6.19e-22) |
0.00149 (1.00) |
0.061 (1.00) |
7.81e-08 (0.000108) |
2.28e-06 (0.00304) |
0.0413 (1.00) |
0.737 (1.00) |
0.00782 (1.00) |
0.151 (1.00) |
0.741 (1.00) |
0.00391 (1.00) |
0.00578 (1.00) |
0.0413 (1.00) |
0.485 (1.00) |
0.781 (1.00) |
0.073 (1.00) |
0.591 (1.00) |
0.417 (1.00) |
|
8q gain |
0.000192 (0.244) |
0.576 (1.00) |
5.25e-86 (8.22e-83) |
9.07e-05 (0.116) |
0.00848 (1.00) |
8.16e-35 (1.23e-31) |
1.08e-14 (1.55e-11) |
1.34e-07 (0.000184) |
0.00811 (1.00) |
1.98e-09 (2.77e-06) |
7.22e-06 (0.00958) |
0.567 (1.00) |
0.0137 (1.00) |
0.0524 (1.00) |
0.167 (1.00) |
0.249 (1.00) |
0.124 (1.00) |
0.0946 (1.00) |
0.301 (1.00) |
0.138 (1.00) |
|
9p gain |
0.0084 (1.00) |
0.737 (1.00) |
8.2e-26 (1.22e-22) |
0.127 (1.00) |
0.382 (1.00) |
8.4e-17 (1.22e-13) |
3.08e-05 (0.0402) |
0.618 (1.00) |
0.199 (1.00) |
0.00172 (1.00) |
0.00153 (1.00) |
0.584 (1.00) |
0.668 (1.00) |
0.491 (1.00) |
0.743 (1.00) |
0.89 (1.00) |
0.19 (1.00) |
0.479 (1.00) |
0.283 (1.00) |
0.108 (1.00) |
|
9q gain |
0.69 (1.00) |
0.713 (1.00) |
1.21e-23 (1.79e-20) |
0.0157 (1.00) |
0.984 (1.00) |
1.32e-21 (1.94e-18) |
1.94e-07 (0.000267) |
0.603 (1.00) |
0.0581 (1.00) |
3.51e-07 (0.00048) |
0.811 (1.00) |
0.756 (1.00) |
0.304 (1.00) |
0.319 (1.00) |
0.742 (1.00) |
0.487 (1.00) |
0.212 (1.00) |
0.286 (1.00) |
0.576 (1.00) |
0.0674 (1.00) |
|
10p gain |
0.0283 (1.00) |
0.922 (1.00) |
1.17e-58 (1.81e-55) |
2.19e-20 (3.2e-17) |
0.915 (1.00) |
1.7e-37 (2.58e-34) |
0.0657 (1.00) |
0.213 (1.00) |
0.00992 (1.00) |
3.16e-13 (4.51e-10) |
0.123 (1.00) |
0.461 (1.00) |
0.577 (1.00) |
7.13e-05 (0.0918) |
0.409 (1.00) |
0.404 (1.00) |
0.483 (1.00) |
0.00132 (1.00) |
0.12 (1.00) |
0.00751 (1.00) |
|
10q gain |
0.0176 (1.00) |
0.847 (1.00) |
1.82e-46 (2.78e-43) |
3.74e-16 (5.41e-13) |
0.316 (1.00) |
3.63e-28 (5.42e-25) |
0.924 (1.00) |
0.0856 (1.00) |
0.394 (1.00) |
8.16e-07 (0.00111) |
0.8 (1.00) |
0.301 (1.00) |
0.838 (1.00) |
0.702 (1.00) |
0.838 (1.00) |
0.96 (1.00) |
0.957 (1.00) |
0.00735 (1.00) |
0.129 (1.00) |
0.0172 (1.00) |
|
11p gain |
0.086 (1.00) |
0.225 (1.00) |
4.94e-15 (7.12e-12) |
0.733 (1.00) |
0.346 (1.00) |
5.54e-06 (0.00737) |
0.0258 (1.00) |
0.222 (1.00) |
0.165 (1.00) |
0.261 (1.00) |
0.0164 (1.00) |
0.253 (1.00) |
0.0325 (1.00) |
0.733 (1.00) |
0.757 (1.00) |
0.865 (1.00) |
0.72 (1.00) |
0.673 (1.00) |
0.304 (1.00) |
0.0164 (1.00) |
|
11q gain |
0.732 (1.00) |
0.00297 (1.00) |
2.5e-16 (3.63e-13) |
0.793 (1.00) |
0.822 (1.00) |
5.8e-09 (8.1e-06) |
0.000622 (0.776) |
0.357 (1.00) |
0.228 (1.00) |
0.0331 (1.00) |
0.000705 (0.876) |
0.271 (1.00) |
8.26e-05 (0.106) |
0.144 (1.00) |
0.249 (1.00) |
0.731 (1.00) |
0.214 (1.00) |
0.422 (1.00) |
0.767 (1.00) |
0.0473 (1.00) |
|
12p gain |
0.812 (1.00) |
0.00149 (1.00) |
1.45e-43 (2.21e-40) |
0.367 (1.00) |
0.0505 (1.00) |
4.59e-25 (6.8e-22) |
0.00034 (0.428) |
0.697 (1.00) |
0.918 (1.00) |
9.68e-09 (1.35e-05) |
4.22e-07 (0.000575) |
0.378 (1.00) |
0.112 (1.00) |
0.213 (1.00) |
0.565 (1.00) |
0.876 (1.00) |
0.778 (1.00) |
0.498 (1.00) |
0.93 (1.00) |
0.921 (1.00) |
|
12q gain |
0.929 (1.00) |
0.00209 (1.00) |
7.1e-15 (1.02e-11) |
0.269 (1.00) |
0.258 (1.00) |
6.49e-05 (0.0837) |
0.0306 (1.00) |
0.688 (1.00) |
0.45 (1.00) |
0.000347 (0.436) |
0.000227 (0.288) |
0.38 (1.00) |
0.656 (1.00) |
0.929 (1.00) |
0.45 (1.00) |
0.0681 (1.00) |
0.948 (1.00) |
0.329 (1.00) |
0.0251 (1.00) |
0.983 (1.00) |
|
13q gain |
0.00394 (1.00) |
6.48e-11 (9.17e-08) |
3.03e-280 (4.83e-277) |
3.06e-05 (0.0399) |
0.116 (1.00) |
2.32e-211 (3.69e-208) |
1.2e-34 (1.81e-31) |
1.68e-06 (0.00225) |
1.36e-05 (0.0179) |
7.91e-08 (0.000109) |
9.57e-15 (1.38e-11) |
0.945 (1.00) |
0.77 (1.00) |
5.18e-07 (0.000705) |
0.129 (1.00) |
0.43 (1.00) |
0.239 (1.00) |
2.95e-05 (0.0385) |
0.869 (1.00) |
0.0352 (1.00) |
|
14q gain |
0.0299 (1.00) |
0.4 (1.00) |
7.71e-29 (1.15e-25) |
0.169 (1.00) |
0.0687 (1.00) |
4.79e-21 (7.03e-18) |
0.00301 (1.00) |
0.564 (1.00) |
0.00508 (1.00) |
0.552 (1.00) |
0.0185 (1.00) |
0.0554 (1.00) |
0.0673 (1.00) |
0.184 (1.00) |
0.283 (1.00) |
0.968 (1.00) |
0.614 (1.00) |
0.239 (1.00) |
0.0571 (1.00) |
0.14 (1.00) |
|
15q gain |
0.116 (1.00) |
0.98 (1.00) |
4.82e-08 (6.65e-05) |
1 (1.00) |
0.213 (1.00) |
5.1e-07 (0.000695) |
0.00018 (0.229) |
0.503 (1.00) |
0.478 (1.00) |
0.321 (1.00) |
0.056 (1.00) |
0.239 (1.00) |
0.686 (1.00) |
0.696 (1.00) |
0.302 (1.00) |
0.349 (1.00) |
0.6 (1.00) |
0.459 (1.00) |
0.306 (1.00) |
0.883 (1.00) |
|
16p gain |
2.01e-09 (2.82e-06) |
0.412 (1.00) |
1.31e-70 (2.04e-67) |
1.28e-06 (0.00172) |
0.0933 (1.00) |
4.74e-17 (6.88e-14) |
0.0296 (1.00) |
0.366 (1.00) |
0.669 (1.00) |
0.581 (1.00) |
0.0104 (1.00) |
0.497 (1.00) |
0.447 (1.00) |
0.36 (1.00) |
0.368 (1.00) |
0.0633 (1.00) |
0.182 (1.00) |
0.148 (1.00) |
0.104 (1.00) |
0.0039 (1.00) |
|
16q gain |
0.0677 (1.00) |
0.848 (1.00) |
2.54e-28 (3.79e-25) |
0.00263 (1.00) |
0.685 (1.00) |
1.06e-21 (1.56e-18) |
0.00998 (1.00) |
0.0626 (1.00) |
0.693 (1.00) |
0.428 (1.00) |
4.1e-06 (0.00546) |
0.477 (1.00) |
0.818 (1.00) |
0.221 (1.00) |
0.329 (1.00) |
0.0841 (1.00) |
0.551 (1.00) |
0.458 (1.00) |
0.965 (1.00) |
0.000739 (0.917) |
|
17p gain |
0.0936 (1.00) |
0.3 (1.00) |
1.5e-06 (0.00201) |
0.0403 (1.00) |
0.65 (1.00) |
9.33e-07 (0.00126) |
0.958 (1.00) |
0.36 (1.00) |
0.0267 (1.00) |
0.59 (1.00) |
0.837 (1.00) |
0.97 (1.00) |
0.262 (1.00) |
0.755 (1.00) |
0.0203 (1.00) |
0.851 (1.00) |
0.84 (1.00) |
0.24 (1.00) |
0.89 (1.00) |
0.628 (1.00) |
|
17q gain |
0.0147 (1.00) |
0.129 (1.00) |
3.22e-30 (4.82e-27) |
0.075 (1.00) |
0.604 (1.00) |
1.46e-19 (2.14e-16) |
0.357 (1.00) |
0.075 (1.00) |
0.0503 (1.00) |
0.0252 (1.00) |
0.176 (1.00) |
0.599 (1.00) |
0.0909 (1.00) |
0.168 (1.00) |
0.183 (1.00) |
0.0255 (1.00) |
0.24 (1.00) |
0.155 (1.00) |
0.873 (1.00) |
0.524 (1.00) |
|
18p gain |
0.19 (1.00) |
0.0722 (1.00) |
9.68e-18 (1.41e-14) |
0.559 (1.00) |
0.029 (1.00) |
2.74e-20 (4.01e-17) |
0.00168 (1.00) |
0.000984 (1.00) |
0.0368 (1.00) |
0.0237 (1.00) |
0.206 (1.00) |
0.00982 (1.00) |
0.258 (1.00) |
0.139 (1.00) |
0.795 (1.00) |
0.329 (1.00) |
0.682 (1.00) |
0.965 (1.00) |
0.166 (1.00) |
0.445 (1.00) |
|
18q gain |
0.142 (1.00) |
0.485 (1.00) |
6.25e-08 (8.62e-05) |
0.313 (1.00) |
0.0821 (1.00) |
4.22e-08 (5.84e-05) |
0.00019 (0.242) |
0.416 (1.00) |
0.365 (1.00) |
0.225 (1.00) |
0.43 (1.00) |
0.0888 (1.00) |
0.0925 (1.00) |
0.132 (1.00) |
0.135 (1.00) |
0.25 (1.00) |
0.966 (1.00) |
0.864 (1.00) |
0.954 (1.00) |
0.504 (1.00) |
|
19p gain |
1.12e-08 (1.56e-05) |
0.311 (1.00) |
5.15e-56 (7.95e-53) |
0.129 (1.00) |
0.464 (1.00) |
1.97e-20 (2.89e-17) |
0.136 (1.00) |
0.0519 (1.00) |
0.109 (1.00) |
0.00111 (1.00) |
3.56e-13 (5.08e-10) |
0.109 (1.00) |
0.135 (1.00) |
0.0228 (1.00) |
0.308 (1.00) |
0.437 (1.00) |
0.911 (1.00) |
0.641 (1.00) |
0.538 (1.00) |
0.814 (1.00) |
|
19q gain |
4.08e-08 (5.64e-05) |
0.0978 (1.00) |
3.05e-30 (4.58e-27) |
0.0566 (1.00) |
0.478 (1.00) |
1.2e-15 (1.73e-12) |
0.0924 (1.00) |
0.176 (1.00) |
0.572 (1.00) |
0.0328 (1.00) |
1.22e-05 (0.0161) |
0.279 (1.00) |
0.0424 (1.00) |
0.0037 (1.00) |
0.231 (1.00) |
0.664 (1.00) |
0.141 (1.00) |
0.513 (1.00) |
0.167 (1.00) |
0.149 (1.00) |
|
20p gain |
4.13e-05 (0.0537) |
7.61e-09 (1.06e-05) |
1.84e-64 (2.87e-61) |
0.0228 (1.00) |
0.965 (1.00) |
2.23e-68 (3.47e-65) |
6.36e-14 (9.12e-11) |
0.0267 (1.00) |
9.41e-06 (0.0124) |
2.76e-07 (0.000378) |
0.67 (1.00) |
0.304 (1.00) |
0.376 (1.00) |
0.00176 (1.00) |
0.0803 (1.00) |
0.0894 (1.00) |
0.222 (1.00) |
6.9e-06 (0.00916) |
0.055 (1.00) |
0.11 (1.00) |
|
20q gain |
0.0121 (1.00) |
3.39e-07 (0.000464) |
1.97e-130 (3.1e-127) |
0.203 (1.00) |
0.344 (1.00) |
1.03e-135 (1.63e-132) |
5.56e-29 (8.32e-26) |
0.000927 (1.00) |
0.000206 (0.261) |
2.83e-15 (4.09e-12) |
0.0142 (1.00) |
0.18 (1.00) |
0.0627 (1.00) |
8.01e-06 (0.0106) |
0.576 (1.00) |
0.435 (1.00) |
0.332 (1.00) |
9.3e-07 (0.00126) |
0.313 (1.00) |
0.0652 (1.00) |
|
21q gain |
0.454 (1.00) |
0.0303 (1.00) |
1.66e-15 (2.4e-12) |
0.00117 (1.00) |
0.307 (1.00) |
4.02e-10 (5.66e-07) |
0.0704 (1.00) |
0.229 (1.00) |
0.836 (1.00) |
0.0112 (1.00) |
0.772 (1.00) |
0.296 (1.00) |
0.471 (1.00) |
1.61e-05 (0.0212) |
0.742 (1.00) |
0.827 (1.00) |
0.0246 (1.00) |
0.135 (1.00) |
0.0824 (1.00) |
0.0112 (1.00) |
|
22q gain |
0.543 (1.00) |
0.0113 (1.00) |
4.2e-36 (6.35e-33) |
2.26e-09 (3.17e-06) |
0.0767 (1.00) |
1.24e-43 (1.9e-40) |
5.6e-07 (0.000761) |
0.0156 (1.00) |
0.807 (1.00) |
0.0143 (1.00) |
0.0313 (1.00) |
0.0683 (1.00) |
0.00222 (1.00) |
0.0541 (1.00) |
0.0265 (1.00) |
0.643 (1.00) |
0.345 (1.00) |
0.315 (1.00) |
0.431 (1.00) |
0.155 (1.00) |
|
Xq gain |
0.0223 (1.00) |
0.0802 (1.00) |
2.22e-08 (3.08e-05) |
0.931 (1.00) |
0.512 (1.00) |
0.00714 (1.00) |
0.0974 (1.00) |
0.0219 (1.00) |
0.0181 (1.00) |
0.123 (1.00) |
0.0169 (1.00) |
0.982 (1.00) |
0.567 (1.00) |
0.627 (1.00) |
0.864 (1.00) |
0.118 (1.00) |
0.0134 (1.00) |
0.405 (1.00) |
0.0954 (1.00) |
0.128 (1.00) |
|
1p loss |
0.0632 (1.00) |
0.00323 (1.00) |
4.3e-20 (6.3e-17) |
0.527 (1.00) |
0.62 (1.00) |
4.74e-08 (6.56e-05) |
0.293 (1.00) |
0.0271 (1.00) |
0.205 (1.00) |
0.833 (1.00) |
0.0252 (1.00) |
0.00638 (1.00) |
0.331 (1.00) |
0.0311 (1.00) |
0.319 (1.00) |
0.14 (1.00) |
0.122 (1.00) |
0.165 (1.00) |
0.00378 (1.00) |
1.07e-05 (0.0142) |
|
1q loss |
0.734 (1.00) |
0.205 (1.00) |
0.000556 (0.696) |
0.137 (1.00) |
0.228 (1.00) |
0.188 (1.00) |
0.0921 (1.00) |
0.306 (1.00) |
0.799 (1.00) |
0.76 (1.00) |
0.458 (1.00) |
0.117 (1.00) |
0.199 (1.00) |
0.852 (1.00) |
0.993 (1.00) |
0.418 (1.00) |
0.973 (1.00) |
0.0296 (1.00) |
0.366 (1.00) |
0.936 (1.00) |
|
2p loss |
0.149 (1.00) |
0.319 (1.00) |
6.03e-17 (8.76e-14) |
6.09e-05 (0.0786) |
0.0276 (1.00) |
0.0848 (1.00) |
0.598 (1.00) |
0.889 (1.00) |
0.881 (1.00) |
0.439 (1.00) |
0.277 (1.00) |
0.539 (1.00) |
0.664 (1.00) |
0.0741 (1.00) |
0.626 (1.00) |
0.576 (1.00) |
0.665 (1.00) |
0.972 (1.00) |
0.463 (1.00) |
0.855 (1.00) |
|
2q loss |
0.162 (1.00) |
0.875 (1.00) |
2.8e-22 (4.12e-19) |
0.00258 (1.00) |
0.0276 (1.00) |
0.205 (1.00) |
0.927 (1.00) |
0.628 (1.00) |
0.153 (1.00) |
0.421 (1.00) |
1 (1.00) |
0.0444 (1.00) |
0.999 (1.00) |
1.65e-05 (0.0216) |
0.768 (1.00) |
0.339 (1.00) |
0.335 (1.00) |
0.358 (1.00) |
0.281 (1.00) |
0.236 (1.00) |
|
3p loss |
0.227 (1.00) |
0.637 (1.00) |
1.29e-218 (2.05e-215) |
7.17e-34 (1.08e-30) |
0.0732 (1.00) |
3.19e-144 (5.04e-141) |
5.56e-14 (7.98e-11) |
0.0222 (1.00) |
0.00016 (0.204) |
4.02e-13 (5.73e-10) |
2.88e-11 (4.08e-08) |
0.0372 (1.00) |
0.12 (1.00) |
5.35e-08 (7.38e-05) |
0.787 (1.00) |
0.771 (1.00) |
0.996 (1.00) |
0.399 (1.00) |
0.0729 (1.00) |
0.715 (1.00) |
|
3q loss |
0.446 (1.00) |
0.56 (1.00) |
6.51e-39 (9.9e-36) |
2.54e-09 (3.55e-06) |
0.963 (1.00) |
3.54e-28 (5.28e-25) |
0.0222 (1.00) |
0.304 (1.00) |
0.0873 (1.00) |
0.000443 (0.555) |
0.345 (1.00) |
0.108 (1.00) |
0.498 (1.00) |
0.0918 (1.00) |
0.0383 (1.00) |
0.914 (1.00) |
0.48 (1.00) |
0.716 (1.00) |
0.609 (1.00) |
0.629 (1.00) |
|
4p loss |
0.385 (1.00) |
0.664 (1.00) |
1.58e-69 (2.47e-66) |
0.0662 (1.00) |
0.00131 (1.00) |
5.22e-66 (8.13e-63) |
0.000198 (0.251) |
1.94e-05 (0.0254) |
0.78 (1.00) |
9.69e-14 (1.39e-10) |
3.67e-10 (5.17e-07) |
0.00449 (1.00) |
0.000486 (0.608) |
0.000563 (0.704) |
0.388 (1.00) |
0.743 (1.00) |
0.647 (1.00) |
0.552 (1.00) |
0.0064 (1.00) |
0.646 (1.00) |
|
4q loss |
0.281 (1.00) |
0.332 (1.00) |
2.93e-108 (4.6e-105) |
1.63e-06 (0.00218) |
0.00244 (1.00) |
6.11e-88 (9.59e-85) |
5.52e-05 (0.0714) |
0.166 (1.00) |
0.909 (1.00) |
6.53e-24 (9.66e-21) |
3.28e-13 (4.68e-10) |
0.0401 (1.00) |
0.0218 (1.00) |
0.0254 (1.00) |
0.116 (1.00) |
0.581 (1.00) |
0.139 (1.00) |
0.467 (1.00) |
0.0279 (1.00) |
0.628 (1.00) |
|
5p loss |
0.179 (1.00) |
0.944 (1.00) |
6.07e-16 (8.79e-13) |
0.000439 (0.551) |
0.827 (1.00) |
9.78e-19 (1.43e-15) |
0.164 (1.00) |
0.524 (1.00) |
0.663 (1.00) |
1.69e-06 (0.00226) |
0.464 (1.00) |
0.599 (1.00) |
0.969 (1.00) |
0.0939 (1.00) |
0.63 (1.00) |
0.835 (1.00) |
0.236 (1.00) |
0.668 (1.00) |
0.179 (1.00) |
0.641 (1.00) |
|
5q loss |
0.434 (1.00) |
0.212 (1.00) |
5.52e-60 (8.57e-57) |
0.86 (1.00) |
0.00434 (1.00) |
2.65e-59 (4.11e-56) |
5.38e-05 (0.0698) |
0.855 (1.00) |
0.152 (1.00) |
1.53e-05 (0.0201) |
0.000245 (0.31) |
0.0874 (1.00) |
0.505 (1.00) |
0.0051 (1.00) |
0.661 (1.00) |
0.46 (1.00) |
0.18 (1.00) |
0.563 (1.00) |
0.339 (1.00) |
0.0064 (1.00) |
|
6p loss |
0.0535 (1.00) |
0.001 (1.00) |
3.98e-28 (5.94e-25) |
1 (1.00) |
0.452 (1.00) |
4.31e-26 (6.4e-23) |
0.501 (1.00) |
0.79 (1.00) |
0.457 (1.00) |
0.000212 (0.269) |
0.797 (1.00) |
0.95 (1.00) |
0.683 (1.00) |
0.561 (1.00) |
0.246 (1.00) |
0.0332 (1.00) |
0.848 (1.00) |
0.000685 (0.852) |
0.351 (1.00) |
0.0844 (1.00) |
|
6q loss |
0.0275 (1.00) |
6.15e-07 (0.000835) |
1.12e-54 (1.73e-51) |
0.00173 (1.00) |
0.173 (1.00) |
7.11e-54 (1.1e-50) |
0.126 (1.00) |
0.853 (1.00) |
0.749 (1.00) |
2.29e-06 (0.00306) |
0.427 (1.00) |
0.00819 (1.00) |
0.94 (1.00) |
0.0348 (1.00) |
0.106 (1.00) |
0.0937 (1.00) |
0.951 (1.00) |
0.0249 (1.00) |
0.588 (1.00) |
0.055 (1.00) |
|
7p loss |
0.45 (1.00) |
0.253 (1.00) |
3.37e-48 (5.16e-45) |
1e-13 (1.43e-10) |
0.319 (1.00) |
1.84e-37 (2.79e-34) |
9e-05 (0.115) |
0.377 (1.00) |
0.735 (1.00) |
1.66e-14 (2.38e-11) |
0.0908 (1.00) |
0.135 (1.00) |
0.00903 (1.00) |
0.515 (1.00) |
0.0224 (1.00) |
0.649 (1.00) |
0.888 (1.00) |
0.42 (1.00) |
0.391 (1.00) |
0.0434 (1.00) |
|
7q loss |
0.745 (1.00) |
0.493 (1.00) |
4.47e-20 (6.54e-17) |
3.65e-11 (5.16e-08) |
0.029 (1.00) |
1.83e-23 (2.7e-20) |
3.89e-05 (0.0506) |
0.517 (1.00) |
0.55 (1.00) |
0.0189 (1.00) |
1 (1.00) |
0.769 (1.00) |
0.738 (1.00) |
0.69 (1.00) |
0.734 (1.00) |
0.0422 (1.00) |
0.99 (1.00) |
0.766 (1.00) |
0.221 (1.00) |
0.0454 (1.00) |
|
8p loss |
0.929 (1.00) |
0.041 (1.00) |
7.91e-53 (1.22e-49) |
0.00238 (1.00) |
0.0785 (1.00) |
8.98e-35 (1.35e-31) |
0.037 (1.00) |
0.141 (1.00) |
0.783 (1.00) |
1.33e-07 (0.000182) |
6.06e-10 (8.53e-07) |
0.068 (1.00) |
0.696 (1.00) |
0.134 (1.00) |
0.529 (1.00) |
0.586 (1.00) |
0.0967 (1.00) |
0.296 (1.00) |
0.00172 (1.00) |
0.865 (1.00) |
|
8q loss |
0.185 (1.00) |
0.203 (1.00) |
1.78e-12 (2.53e-09) |
1 (1.00) |
0.0058 (1.00) |
8.37e-10 (1.18e-06) |
0.0646 (1.00) |
0.404 (1.00) |
0.8 (1.00) |
0.000142 (0.182) |
0.719 (1.00) |
0.335 (1.00) |
0.902 (1.00) |
0.286 (1.00) |
0.818 (1.00) |
0.412 (1.00) |
0.525 (1.00) |
0.106 (1.00) |
0.656 (1.00) |
0.642 (1.00) |
|
9p loss |
2.53e-13 (3.61e-10) |
0.0669 (1.00) |
3.23e-49 (4.96e-46) |
0.00234 (1.00) |
0.22 (1.00) |
2.07e-49 (3.18e-46) |
9.7e-09 (1.35e-05) |
0.349 (1.00) |
0.742 (1.00) |
0.014 (1.00) |
0.127 (1.00) |
0.00247 (1.00) |
0.392 (1.00) |
0.187 (1.00) |
0.0454 (1.00) |
0.342 (1.00) |
0.0351 (1.00) |
0.0671 (1.00) |
0.274 (1.00) |
0.0254 (1.00) |
|
9q loss |
0.00016 (0.204) |
0.000739 (0.917) |
8.8e-58 (1.36e-54) |
0.00104 (1.00) |
0.787 (1.00) |
1.1e-56 (1.7e-53) |
0.00031 (0.39) |
0.00849 (1.00) |
0.434 (1.00) |
7.3e-09 (1.02e-05) |
0.00372 (1.00) |
0.151 (1.00) |
0.708 (1.00) |
0.0259 (1.00) |
0.0626 (1.00) |
0.305 (1.00) |
0.0552 (1.00) |
0.0286 (1.00) |
0.368 (1.00) |
0.0174 (1.00) |
|
10p loss |
0 (0) |
0.379 (1.00) |
0 (0) |
2.5e-22 (3.68e-19) |
0.00339 (1.00) |
9.96e-37 (1.51e-33) |
0.00377 (1.00) |
0.285 (1.00) |
0.85 (1.00) |
0.446 (1.00) |
9.03e-59 (1.4e-55) |
0.974 (1.00) |
0.0223 (1.00) |
0.593 (1.00) |
0.474 (1.00) |
0.884 (1.00) |
0.824 (1.00) |
0.66 (1.00) |
0.794 (1.00) |
0.514 (1.00) |
|
10q loss |
0 (0) |
0.0541 (1.00) |
0 (0) |
2.6e-17 (3.78e-14) |
0.000962 (1.00) |
5.71e-41 (8.7e-38) |
0.0807 (1.00) |
0.75 (1.00) |
0.633 (1.00) |
0.902 (1.00) |
2.56e-56 (3.96e-53) |
0.886 (1.00) |
0.104 (1.00) |
0.108 (1.00) |
0.503 (1.00) |
0.871 (1.00) |
0.277 (1.00) |
0.644 (1.00) |
0.972 (1.00) |
0.419 (1.00) |
|
11p loss |
0.00257 (1.00) |
0.469 (1.00) |
7.63e-41 (1.16e-37) |
1.95e-05 (0.0255) |
0.758 (1.00) |
1.17e-36 (1.76e-33) |
0.105 (1.00) |
4.77e-05 (0.0619) |
0.685 (1.00) |
2.7e-12 (3.84e-09) |
0.251 (1.00) |
0.344 (1.00) |
0.16 (1.00) |
2.25e-06 (0.00301) |
0.0494 (1.00) |
0.678 (1.00) |
0.0685 (1.00) |
0.815 (1.00) |
0.00279 (1.00) |
0.000208 (0.264) |
|
11q loss |
0.632 (1.00) |
0.974 (1.00) |
2.05e-44 (3.13e-41) |
5.76e-05 (0.0745) |
0.88 (1.00) |
4.7e-22 (6.92e-19) |
0.0392 (1.00) |
0.00121 (1.00) |
0.741 (1.00) |
1.04e-05 (0.0138) |
0.777 (1.00) |
0.899 (1.00) |
0.75 (1.00) |
0.069 (1.00) |
0.0573 (1.00) |
0.836 (1.00) |
0.129 (1.00) |
0.459 (1.00) |
0.0695 (1.00) |
0.0386 (1.00) |
|
12p loss |
0.0587 (1.00) |
0.206 (1.00) |
2.2e-07 (0.000301) |
0.00625 (1.00) |
0.961 (1.00) |
1.32e-10 (1.86e-07) |
0.00588 (1.00) |
0.0277 (1.00) |
0.152 (1.00) |
0.137 (1.00) |
0.155 (1.00) |
0.0079 (1.00) |
0.647 (1.00) |
0.764 (1.00) |
0.000571 (0.713) |
0.554 (1.00) |
0.555 (1.00) |
0.578 (1.00) |
0.883 (1.00) |
0.414 (1.00) |
|
12q loss |
0.163 (1.00) |
0.325 (1.00) |
3.31e-16 (4.79e-13) |
0.00183 (1.00) |
0.95 (1.00) |
7.04e-16 (1.02e-12) |
0.132 (1.00) |
0.075 (1.00) |
0.286 (1.00) |
0.00992 (1.00) |
0.862 (1.00) |
0.593 (1.00) |
0.626 (1.00) |
0.347 (1.00) |
0.0973 (1.00) |
0.703 (1.00) |
0.584 (1.00) |
0.615 (1.00) |
0.488 (1.00) |
0.129 (1.00) |
|
13q loss |
0.00165 (1.00) |
0.194 (1.00) |
7.7e-88 (1.21e-84) |
1.22e-06 (0.00165) |
0.173 (1.00) |
1.53e-83 (2.4e-80) |
9.98e-12 (1.42e-08) |
0.0228 (1.00) |
0.42 (1.00) |
1.38e-08 (1.92e-05) |
0.211 (1.00) |
0.27 (1.00) |
0.0886 (1.00) |
0.0203 (1.00) |
0.563 (1.00) |
0.913 (1.00) |
0.0971 (1.00) |
0.604 (1.00) |
0.139 (1.00) |
0.22 (1.00) |
|
14q loss |
0.00277 (1.00) |
0.205 (1.00) |
1.77e-38 (2.68e-35) |
0.0381 (1.00) |
0.823 (1.00) |
1.06e-38 (1.61e-35) |
2.02e-07 (0.000277) |
0.000151 (0.193) |
5.75e-05 (0.0744) |
0.000671 (0.836) |
0.0861 (1.00) |
0.339 (1.00) |
0.111 (1.00) |
0.283 (1.00) |
0.741 (1.00) |
0.942 (1.00) |
0.189 (1.00) |
0.109 (1.00) |
0.345 (1.00) |
0.248 (1.00) |
|
15q loss |
0.283 (1.00) |
0.00988 (1.00) |
3.19e-60 (4.96e-57) |
1.96e-12 (2.78e-09) |
0.936 (1.00) |
3.38e-63 (5.25e-60) |
1.85e-06 (0.00248) |
0.0822 (1.00) |
0.136 (1.00) |
3.04e-14 (4.37e-11) |
0.00398 (1.00) |
0.704 (1.00) |
0.362 (1.00) |
0.608 (1.00) |
0.454 (1.00) |
0.12 (1.00) |
0.539 (1.00) |
0.191 (1.00) |
0.0579 (1.00) |
0.704 (1.00) |
|
16p loss |
0.00995 (1.00) |
0.758 (1.00) |
3.63e-173 (5.75e-170) |
8.69e-20 (1.27e-16) |
0.304 (1.00) |
1.47e-134 (2.31e-131) |
0.00102 (1.00) |
0.813 (1.00) |
0.774 (1.00) |
9.54e-28 (1.42e-24) |
3.42e-06 (0.00456) |
0.283 (1.00) |
0.941 (1.00) |
0.0613 (1.00) |
0.44 (1.00) |
0.939 (1.00) |
0.83 (1.00) |
0.0073 (1.00) |
0.966 (1.00) |
0.601 (1.00) |
|
16q loss |
0.00145 (1.00) |
0.668 (1.00) |
1.19e-229 (1.89e-226) |
7.3e-72 (1.14e-68) |
0.0846 (1.00) |
1.95e-195 (3.1e-192) |
1.01e-06 (0.00136) |
0.392 (1.00) |
0.643 (1.00) |
3.38e-42 (5.15e-39) |
0.000689 (0.857) |
0.229 (1.00) |
0.387 (1.00) |
0.032 (1.00) |
0.797 (1.00) |
0.146 (1.00) |
0.0779 (1.00) |
1.07e-05 (0.0141) |
0.221 (1.00) |
9.99e-06 (0.0132) |
|
17p loss |
0.0253 (1.00) |
0.362 (1.00) |
2.2e-195 (3.49e-192) |
1.96e-32 (2.94e-29) |
0.00321 (1.00) |
5.37e-162 (8.48e-159) |
2.22e-07 (0.000304) |
0.00366 (1.00) |
0.0556 (1.00) |
2.74e-31 (4.12e-28) |
3.23e-23 (4.76e-20) |
0.292 (1.00) |
0.483 (1.00) |
0.259 (1.00) |
0.714 (1.00) |
0.61 (1.00) |
0.77 (1.00) |
0.00132 (1.00) |
0.0512 (1.00) |
0.0524 (1.00) |
|
17q loss |
0.869 (1.00) |
0.00759 (1.00) |
9.79e-204 (1.56e-200) |
8.72e-49 (1.34e-45) |
0.945 (1.00) |
1.38e-170 (2.19e-167) |
0.544 (1.00) |
0.0672 (1.00) |
0.277 (1.00) |
2.14e-45 (3.27e-42) |
2.1e-08 (2.91e-05) |
0.5 (1.00) |
0.831 (1.00) |
0.164 (1.00) |
0.39 (1.00) |
0.502 (1.00) |
0.367 (1.00) |
8.95e-05 (0.115) |
0.467 (1.00) |
0.13 (1.00) |
|
18p loss |
0.805 (1.00) |
0.000808 (0.999) |
1.86e-147 (2.94e-144) |
0.057 (1.00) |
0.916 (1.00) |
1.74e-130 (2.74e-127) |
1.75e-26 (2.6e-23) |
0.000217 (0.275) |
4.8e-09 (6.72e-06) |
5e-12 (7.09e-09) |
4.81e-12 (6.83e-09) |
0.00564 (1.00) |
0.449 (1.00) |
0.701 (1.00) |
0.00913 (1.00) |
0.328 (1.00) |
0.36 (1.00) |
0.000346 (0.435) |
0.0572 (1.00) |
0.41 (1.00) |
|
18q loss |
0.842 (1.00) |
3.22e-05 (0.042) |
6.45e-148 (1.02e-144) |
0.887 (1.00) |
0.373 (1.00) |
1.9e-112 (2.98e-109) |
3.09e-24 (4.58e-21) |
8.37e-07 (0.00113) |
2.29e-05 (0.0299) |
5.26e-14 (7.55e-11) |
2.46e-19 (3.59e-16) |
0.299 (1.00) |
0.733 (1.00) |
0.0675 (1.00) |
0.0135 (1.00) |
0.395 (1.00) |
0.387 (1.00) |
0.00296 (1.00) |
0.0708 (1.00) |
0.096 (1.00) |
|
19p loss |
0.00671 (1.00) |
0.832 (1.00) |
6.43e-67 (1e-63) |
0.00229 (1.00) |
0.669 (1.00) |
3.63e-51 (5.59e-48) |
2.22e-07 (0.000304) |
0.307 (1.00) |
0.0399 (1.00) |
3.85e-06 (0.00513) |
2.75e-06 (0.00367) |
0.72 (1.00) |
0.648 (1.00) |
0.00738 (1.00) |
0.0133 (1.00) |
0.128 (1.00) |
0.0726 (1.00) |
0.3 (1.00) |
0.318 (1.00) |
0.153 (1.00) |
|
19q loss |
0.0664 (1.00) |
0.273 (1.00) |
5.1e-64 (7.94e-61) |
5.16e-07 (0.000703) |
0.873 (1.00) |
1.28e-50 (1.97e-47) |
0.00706 (1.00) |
0.971 (1.00) |
0.167 (1.00) |
8.01e-10 (1.13e-06) |
0.00171 (1.00) |
0.188 (1.00) |
0.572 (1.00) |
0.145 (1.00) |
0.0111 (1.00) |
0.695 (1.00) |
0.109 (1.00) |
0.00413 (1.00) |
0.864 (1.00) |
0.116 (1.00) |
|
20p loss |
0.724 (1.00) |
0.779 (1.00) |
1.02e-10 (1.45e-07) |
0.422 (1.00) |
0.963 (1.00) |
5.75e-09 (8.03e-06) |
0.00253 (1.00) |
0.044 (1.00) |
0.401 (1.00) |
0.179 (1.00) |
0.0187 (1.00) |
0.994 (1.00) |
0.457 (1.00) |
0.629 (1.00) |
0.0616 (1.00) |
0.527 (1.00) |
0.561 (1.00) |
0.906 (1.00) |
0.261 (1.00) |
0.215 (1.00) |
|
20q loss |
0.631 (1.00) |
0.534 (1.00) |
9.63e-09 (1.34e-05) |
0.92 (1.00) |
0.335 (1.00) |
8.42e-07 (0.00114) |
0.0205 (1.00) |
0.472 (1.00) |
0.617 (1.00) |
0.165 (1.00) |
0.0577 (1.00) |
0.644 (1.00) |
0.722 (1.00) |
0.623 (1.00) |
0.159 (1.00) |
0.546 (1.00) |
0.928 (1.00) |
0.336 (1.00) |
0.459 (1.00) |
0.666 (1.00) |
|
21q loss |
0.817 (1.00) |
0.342 (1.00) |
2.1e-46 (3.21e-43) |
0.147 (1.00) |
0.0337 (1.00) |
1.61e-27 (2.4e-24) |
0.0199 (1.00) |
0.00555 (1.00) |
0.726 (1.00) |
5.65e-06 (0.00751) |
1.08e-07 (0.000149) |
0.11 (1.00) |
5.24e-05 (0.068) |
0.0646 (1.00) |
0.996 (1.00) |
0.0811 (1.00) |
0.677 (1.00) |
0.83 (1.00) |
0.0647 (1.00) |
0.0334 (1.00) |
|
22q loss |
5.47e-05 (0.0708) |
0.266 (1.00) |
2.28e-167 (3.61e-164) |
5.59e-34 (8.42e-31) |
0.017 (1.00) |
8.78e-170 (1.39e-166) |
0.000676 (0.842) |
0.000747 (0.925) |
0.53 (1.00) |
3.92e-53 (6.04e-50) |
0.659 (1.00) |
0.401 (1.00) |
0.863 (1.00) |
0.102 (1.00) |
0.0119 (1.00) |
0.658 (1.00) |
0.116 (1.00) |
0.000853 (1.00) |
0.182 (1.00) |
0.188 (1.00) |
|
Xq loss |
0.394 (1.00) |
0.0846 (1.00) |
5.04e-48 (7.72e-45) |
4.06e-07 (0.000553) |
0.838 (1.00) |
5.42e-35 (8.18e-32) |
0.82 (1.00) |
0.556 (1.00) |
0.975 (1.00) |
2.78e-10 (3.92e-07) |
0.00345 (1.00) |
0.136 (1.00) |
0.246 (1.00) |
0.585 (1.00) |
0.925 (1.00) |
0.684 (1.00) |
1 (1.00) |
0.102 (1.00) |
0.444 (1.00) |
0.000281 (0.354) |
Cluster Labels | 1P GAIN MUTATED | 1P GAIN WILD-TYPE |
---|---|---|
Number of samples | 359 | 4204 |
P value = 1.5e-28 (Chi-square test), Q value = 2.2e-25
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
1P GAIN MUTATED | 15 | 38 | 97 | 9 | 17 | 11 | 5 | 76 | 1 | 85 | 1 | 4 |
1P GAIN WILD-TYPE | 110 | 506 | 749 | 403 | 430 | 308 | 488 | 586 | 1 | 463 | 1 | 155 |
P value = 8.6e-07 (Fisher's exact test), Q value = 0.0012
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
1P GAIN MUTATED | 269 | 90 |
1P GAIN WILD-TYPE | 2612 | 1592 |
P value = 1.45e-29 (Chi-square test), Q value = 2.2e-26
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
1P GAIN MUTATED | 8 | 1 | 10 | 11 | 5 | 1 | 10 | 30 | 4 | 0 | 3 | 0 | 1 | 0 | 2 | 0 | 0 | 1 | 0 | 23 | 0 | 1 | 3 | 1 | 87 | 7 | 0 | 1 |
1P GAIN WILD-TYPE | 348 | 53 | 340 | 308 | 488 | 9 | 65 | 175 | 3 | 3 | 12 | 2 | 2 | 2 | 11 | 1 | 1 | 0 | 2 | 292 | 18 | 6 | 140 | 12 | 465 | 72 | 1 | 19 |
P value = 0.000161 (Chi-square test), Q value = 0.21
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
1P GAIN MUTATED | 19 | 53 | 24 | 7 |
1P GAIN WILD-TYPE | 447 | 579 | 670 | 202 |
Cluster Labels | 1Q GAIN MUTATED | 1Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 1174 | 3389 |
P value = 2.04e-10 (logrank test), Q value = 2.9e-07
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
1Q GAIN MUTATED | 1116 | 275 | 0.0 - 223.4 (15.2) |
1Q GAIN WILD-TYPE | 3180 | 1126 | 0.0 - 224.0 (14.5) |
P value = 3.09e-135 (Chi-square test), Q value = 4.9e-132
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
1Q GAIN MUTATED | 29 | 42 | 464 | 51 | 133 | 39 | 31 | 206 | 1 | 150 | 2 | 25 |
1Q GAIN WILD-TYPE | 96 | 502 | 382 | 361 | 314 | 280 | 462 | 456 | 1 | 398 | 0 | 134 |
P value = 1.89e-33 (Fisher's exact test), Q value = 2.8e-30
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
1Q GAIN MUTATED | 909 | 265 |
1Q GAIN WILD-TYPE | 1972 | 1417 |
P value = 2.19e-39 (Chi-square test), Q value = 3.3e-36
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
1Q GAIN MUTATED | 48 | 3 | 116 | 39 | 31 | 4 | 34 | 75 | 6 | 0 | 7 | 1 | 2 | 0 | 7 | 0 | 0 | 1 | 1 | 66 | 3 | 2 | 21 | 4 | 153 | 14 | 0 | 1 |
1Q GAIN WILD-TYPE | 308 | 51 | 234 | 280 | 462 | 6 | 41 | 130 | 1 | 3 | 8 | 1 | 1 | 2 | 6 | 1 | 1 | 0 | 1 | 249 | 15 | 5 | 122 | 9 | 399 | 65 | 1 | 19 |
P value = 1.65e-05 (Chi-square test), Q value = 0.022
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
1Q GAIN MUTATED | 71 | 140 | 88 | 45 |
1Q GAIN WILD-TYPE | 395 | 492 | 606 | 164 |
Cluster Labels | 2P GAIN MUTATED | 2P GAIN WILD-TYPE |
---|---|---|
Number of samples | 518 | 4045 |
P value = 0.000113 (t-test), Q value = 0.15
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 4507 | 61.9 (12.6) |
2P GAIN MUTATED | 507 | 63.8 (12.1) |
2P GAIN WILD-TYPE | 4000 | 61.6 (12.7) |
P value = 1.25e-30 (Chi-square test), Q value = 1.9e-27
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
2P GAIN MUTATED | 26 | 18 | 50 | 39 | 47 | 31 | 46 | 119 | 0 | 122 | 0 | 20 |
2P GAIN WILD-TYPE | 99 | 526 | 796 | 373 | 400 | 288 | 447 | 543 | 2 | 426 | 2 | 139 |
P value = 1.8e-13 (Chi-square test), Q value = 2.6e-10
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
2P GAIN MUTATED | 38 | 1 | 31 | 31 | 46 | 1 | 11 | 26 | 5 | 0 | 1 | 1 | 0 | 0 | 3 | 1 | 0 | 0 | 0 | 70 | 3 | 0 | 20 | 0 | 122 | 13 | 0 | 0 |
2P GAIN WILD-TYPE | 318 | 53 | 319 | 288 | 447 | 9 | 64 | 179 | 2 | 3 | 14 | 1 | 3 | 2 | 10 | 0 | 1 | 1 | 2 | 245 | 15 | 7 | 123 | 13 | 430 | 66 | 1 | 20 |
P value = 6.7e-06 (Fisher's exact test), Q value = 0.0089
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
2P GAIN MUTATED | 58 | 460 |
2P GAIN WILD-TYPE | 768 | 3277 |
P value = 2.47e-05 (Chi-square test), Q value = 0.032
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE TIS | STAGE X |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 72 | 62 | 7 | 43 | 287 | 186 | 42 | 124 | 25 | 41 | 59 | 1 | 16 |
2P GAIN MUTATED | 1 | 3 | 0 | 8 | 21 | 10 | 7 | 6 | 0 | 2 | 13 | 0 | 3 |
2P GAIN WILD-TYPE | 71 | 59 | 7 | 35 | 266 | 176 | 35 | 118 | 25 | 39 | 46 | 1 | 13 |
Cluster Labels | 2Q GAIN MUTATED | 2Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 396 | 4167 |
P value = 1.17e-21 (Chi-square test), Q value = 1.7e-18
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
2Q GAIN MUTATED | 14 | 15 | 27 | 38 | 37 | 22 | 48 | 78 | 0 | 96 | 0 | 21 |
2Q GAIN WILD-TYPE | 111 | 529 | 819 | 374 | 410 | 297 | 445 | 584 | 2 | 452 | 2 | 138 |
P value = 1e-08 (Chi-square test), Q value = 1.4e-05
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
2Q GAIN MUTATED | 37 | 1 | 25 | 22 | 48 | 1 | 8 | 25 | 5 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 0 | 0 | 34 | 1 | 0 | 21 | 0 | 96 | 11 | 0 | 0 |
2Q GAIN WILD-TYPE | 319 | 53 | 325 | 297 | 445 | 9 | 67 | 180 | 2 | 3 | 15 | 2 | 3 | 2 | 9 | 0 | 1 | 1 | 2 | 281 | 17 | 7 | 122 | 13 | 456 | 68 | 1 | 20 |
Cluster Labels | 3P GAIN MUTATED | 3P GAIN WILD-TYPE |
---|---|---|
Number of samples | 365 | 4198 |
P value = 2.71e-30 (Chi-square test), Q value = 4.1e-27
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
3P GAIN MUTATED | 28 | 28 | 58 | 19 | 24 | 29 | 5 | 58 | 0 | 99 | 1 | 15 |
3P GAIN WILD-TYPE | 97 | 516 | 788 | 393 | 423 | 290 | 488 | 604 | 2 | 449 | 1 | 144 |
P value = 6.17e-19 (Chi-square test), Q value = 9e-16
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
3P GAIN MUTATED | 18 | 1 | 18 | 29 | 5 | 1 | 2 | 8 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 45 | 0 | 0 | 15 | 0 | 100 | 6 | 0 | 1 |
3P GAIN WILD-TYPE | 338 | 53 | 332 | 290 | 488 | 9 | 73 | 197 | 6 | 3 | 15 | 2 | 3 | 2 | 12 | 1 | 1 | 1 | 2 | 270 | 18 | 7 | 128 | 13 | 452 | 73 | 1 | 19 |
P value = 7.88e-05 (Chi-square test), Q value = 0.1
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
3P GAIN MUTATED | 37 | 39 | 103 | 37 |
3P GAIN WILD-TYPE | 675 | 459 | 778 | 386 |
P value = 4.65e-05 (Chi-square test), Q value = 0.06
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE TIS | STAGE X |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 72 | 62 | 7 | 43 | 287 | 186 | 42 | 124 | 25 | 41 | 59 | 1 | 16 |
3P GAIN MUTATED | 4 | 1 | 0 | 9 | 25 | 7 | 5 | 13 | 4 | 2 | 14 | 0 | 0 |
3P GAIN WILD-TYPE | 68 | 61 | 7 | 34 | 262 | 179 | 37 | 111 | 21 | 39 | 45 | 1 | 16 |
Cluster Labels | 3Q GAIN MUTATED | 3Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 758 | 3805 |
P value = 2.2e-87 (Chi-square test), Q value = 3.5e-84
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
3Q GAIN MUTATED | 36 | 28 | 99 | 28 | 44 | 104 | 20 | 180 | 0 | 193 | 2 | 23 |
3Q GAIN WILD-TYPE | 89 | 516 | 747 | 384 | 403 | 215 | 473 | 482 | 2 | 355 | 0 | 136 |
P value = 1.53e-05 (t-test), Q value = 0.02
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 640 | 73.6 (23.9) |
3Q GAIN MUTATED | 90 | 58.8 (34.9) |
3Q GAIN WILD-TYPE | 550 | 76.0 (20.7) |
P value = 1.25e-88 (Chi-square test), Q value = 2e-85
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
3Q GAIN MUTATED | 26 | 2 | 24 | 104 | 20 | 1 | 4 | 16 | 5 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 152 | 2 | 0 | 23 | 0 | 195 | 18 | 0 | 1 |
3Q GAIN WILD-TYPE | 330 | 52 | 326 | 215 | 473 | 9 | 71 | 189 | 2 | 3 | 15 | 2 | 3 | 2 | 11 | 1 | 1 | 1 | 2 | 163 | 16 | 7 | 120 | 13 | 357 | 61 | 1 | 19 |
P value = 6.96e-07 (Chi-square test), Q value = 0.00094
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
3Q GAIN MUTATED | 72 | 138 | 80 | 48 |
3Q GAIN WILD-TYPE | 394 | 494 | 614 | 161 |
P value = 9.15e-06 (Chi-square test), Q value = 0.012
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 1067 | 353 | 282 | 11 |
3Q GAIN MUTATED | 166 | 86 | 63 | 6 |
3Q GAIN WILD-TYPE | 901 | 267 | 219 | 5 |
P value = 1.34e-06 (Chi-square test), Q value = 0.0018
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
3Q GAIN MUTATED | 112 | 86 | 228 | 98 |
3Q GAIN WILD-TYPE | 600 | 412 | 653 | 325 |
P value = 0.00013 (Fisher's exact test), Q value = 0.17
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
3Q GAIN MUTATED | 101 | 657 |
3Q GAIN WILD-TYPE | 725 | 3080 |
Cluster Labels | 4P GAIN MUTATED | 4P GAIN WILD-TYPE |
---|---|---|
Number of samples | 151 | 4412 |
P value = 1.01e-06 (Chi-square test), Q value = 0.0014
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
4P GAIN MUTATED | 8 | 11 | 32 | 2 | 5 | 14 | 8 | 37 | 0 | 30 | 0 | 4 |
4P GAIN WILD-TYPE | 117 | 533 | 814 | 410 | 442 | 305 | 485 | 625 | 2 | 518 | 2 | 155 |
P value = 1.31e-06 (Chi-square test), Q value = 0.0018
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
4P GAIN MUTATED | 2 | 0 | 1 | 14 | 8 | 1 | 3 | 18 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 13 | 0 | 0 | 4 | 0 | 30 | 4 | 0 | 0 |
4P GAIN WILD-TYPE | 354 | 54 | 349 | 305 | 485 | 9 | 72 | 187 | 6 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 1 | 302 | 18 | 7 | 139 | 13 | 522 | 75 | 1 | 20 |
Cluster Labels | 4Q GAIN MUTATED | 4Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 101 | 4462 |
Cluster Labels | 5P GAIN MUTATED | 5P GAIN WILD-TYPE |
---|---|---|
Number of samples | 963 | 3600 |
P value = 3.72e-05 (t-test), Q value = 0.048
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 4507 | 61.9 (12.6) |
5P GAIN MUTATED | 949 | 63.3 (11.7) |
5P GAIN WILD-TYPE | 3558 | 61.5 (12.8) |
P value = 7.92e-83 (Chi-square test), Q value = 1.2e-79
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
5P GAIN MUTATED | 38 | 27 | 166 | 37 | 29 | 81 | 133 | 287 | 0 | 142 | 2 | 21 |
5P GAIN WILD-TYPE | 87 | 517 | 680 | 375 | 418 | 238 | 360 | 375 | 2 | 406 | 0 | 138 |
P value = 1.28e-52 (Chi-square test), Q value = 2e-49
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
5P GAIN MUTATED | 34 | 3 | 11 | 81 | 133 | 2 | 31 | 82 | 4 | 1 | 6 | 2 | 2 | 0 | 4 | 0 | 0 | 1 | 1 | 151 | 1 | 0 | 21 | 0 | 144 | 17 | 1 | 1 |
5P GAIN WILD-TYPE | 322 | 51 | 339 | 238 | 360 | 8 | 44 | 123 | 3 | 2 | 9 | 0 | 1 | 2 | 9 | 1 | 1 | 0 | 1 | 164 | 17 | 7 | 122 | 13 | 408 | 62 | 0 | 19 |
P value = 8.46e-10 (Chi-square test), Q value = 1.2e-06
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
5P GAIN MUTATED | 133 | 225 | 135 | 50 |
5P GAIN WILD-TYPE | 333 | 407 | 559 | 159 |
P value = 1.41e-08 (Fisher's exact test), Q value = 2e-05
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
5P GAIN MUTATED | 116 | 847 |
5P GAIN WILD-TYPE | 710 | 2890 |
Cluster Labels | 5Q GAIN MUTATED | 5Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 463 | 4100 |
P value = 9.05e-58 (Chi-square test), Q value = 1.4e-54
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
5Q GAIN MUTATED | 16 | 20 | 100 | 20 | 8 | 30 | 145 | 83 | 0 | 29 | 1 | 11 |
5Q GAIN WILD-TYPE | 109 | 524 | 746 | 392 | 439 | 289 | 348 | 579 | 2 | 519 | 1 | 148 |
P value = 4.57e-43 (Chi-square test), Q value = 7e-40
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
5Q GAIN MUTATED | 19 | 1 | 3 | 30 | 145 | 1 | 11 | 28 | 1 | 1 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 37 | 0 | 0 | 11 | 0 | 30 | 5 | 1 | 0 |
5Q GAIN WILD-TYPE | 337 | 53 | 347 | 289 | 348 | 9 | 64 | 177 | 6 | 2 | 14 | 1 | 3 | 2 | 11 | 1 | 1 | 1 | 2 | 278 | 18 | 7 | 132 | 13 | 522 | 74 | 0 | 20 |
Cluster Labels | 6P GAIN MUTATED | 6P GAIN WILD-TYPE |
---|---|---|
Number of samples | 453 | 4110 |
P value = 1.08e-35 (Chi-square test), Q value = 1.6e-32
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
6P GAIN MUTATED | 10 | 5 | 100 | 47 | 34 | 26 | 5 | 83 | 0 | 115 | 1 | 27 |
6P GAIN WILD-TYPE | 115 | 539 | 746 | 365 | 413 | 293 | 488 | 579 | 2 | 433 | 1 | 132 |
P value = 3.41e-07 (Fisher's exact test), Q value = 0.00047
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
6P GAIN MUTATED | 335 | 118 |
6P GAIN WILD-TYPE | 2546 | 1564 |
P value = 4.48e-22 (Chi-square test), Q value = 6.6e-19
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
6P GAIN MUTATED | 40 | 7 | 20 | 26 | 5 | 3 | 13 | 28 | 0 | 0 | 4 | 1 | 1 | 0 | 2 | 0 | 0 | 1 | 0 | 30 | 0 | 0 | 27 | 0 | 116 | 14 | 0 | 0 |
6P GAIN WILD-TYPE | 316 | 47 | 330 | 293 | 488 | 7 | 62 | 177 | 7 | 3 | 11 | 1 | 2 | 2 | 11 | 1 | 1 | 0 | 2 | 285 | 18 | 7 | 116 | 13 | 436 | 65 | 1 | 20 |
P value = 6.63e-07 (Chi-square test), Q value = 9e-04
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
6P GAIN MUTATED | 53 | 54 | 144 | 45 |
6P GAIN WILD-TYPE | 659 | 444 | 737 | 378 |
Cluster Labels | 6Q GAIN MUTATED | 6Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 295 | 4268 |
P value = 1.31e-18 (Chi-square test), Q value = 1.9e-15
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
6Q GAIN MUTATED | 6 | 7 | 65 | 43 | 31 | 19 | 4 | 33 | 0 | 60 | 0 | 26 |
6Q GAIN WILD-TYPE | 119 | 537 | 781 | 369 | 416 | 300 | 489 | 629 | 2 | 488 | 2 | 133 |
P value = 2.41e-13 (Chi-square test), Q value = 3.4e-10
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
6Q GAIN MUTATED | 38 | 5 | 17 | 19 | 4 | 0 | 2 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 18 | 0 | 0 | 26 | 0 | 60 | 14 | 0 | 0 |
6Q GAIN WILD-TYPE | 318 | 49 | 333 | 300 | 489 | 10 | 73 | 194 | 7 | 3 | 15 | 2 | 3 | 2 | 12 | 1 | 1 | 0 | 2 | 297 | 18 | 7 | 117 | 13 | 492 | 65 | 1 | 20 |
P value = 6.68e-05 (Chi-square test), Q value = 0.086
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
6Q GAIN MUTATED | 13 | 31 | 63 | 16 |
6Q GAIN WILD-TYPE | 453 | 601 | 631 | 193 |
P value = 1.85e-05 (Chi-square test), Q value = 0.024
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
6Q GAIN MUTATED | 24 | 38 | 86 | 32 |
6Q GAIN WILD-TYPE | 688 | 460 | 795 | 391 |
Cluster Labels | 7P GAIN MUTATED | 7P GAIN WILD-TYPE |
---|---|---|
Number of samples | 1455 | 3108 |
P value = 0 (logrank test), Q value = 0
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
7P GAIN MUTATED | 1360 | 572 | 0.0 - 224.0 (11.0) |
7P GAIN WILD-TYPE | 2936 | 829 | 0.0 - 223.4 (17.5) |
P value = 1.14e-166 (Chi-square test), Q value = 1.8e-163
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
7P GAIN MUTATED | 35 | 412 | 156 | 199 | 40 | 73 | 127 | 210 | 0 | 112 | 0 | 89 |
7P GAIN WILD-TYPE | 90 | 132 | 690 | 213 | 407 | 246 | 366 | 452 | 2 | 436 | 2 | 70 |
P value = 6.39e-27 (Fisher's exact test), Q value = 9.5e-24
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
7P GAIN MUTATED | 754 | 701 |
7P GAIN WILD-TYPE | 2127 | 981 |
P value = 1.01e-51 (Chi-square test), Q value = 1.6e-48
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
7P GAIN MUTATED | 184 | 15 | 27 | 73 | 127 | 5 | 20 | 78 | 3 | 2 | 4 | 0 | 1 | 0 | 5 | 1 | 0 | 0 | 1 | 89 | 1 | 1 | 87 | 2 | 112 | 12 | 0 | 14 |
7P GAIN WILD-TYPE | 172 | 39 | 323 | 246 | 366 | 5 | 55 | 127 | 4 | 1 | 11 | 2 | 2 | 2 | 8 | 0 | 1 | 1 | 1 | 226 | 17 | 6 | 56 | 11 | 440 | 67 | 1 | 6 |
P value = 1.49e-09 (Chi-square test), Q value = 2.1e-06
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
7P GAIN MUTATED | 110 | 221 | 294 | 67 |
7P GAIN WILD-TYPE | 356 | 411 | 400 | 142 |
P value = 7.41e-05 (Chi-square test), Q value = 0.095
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 1424 | 168 | 9 | 3 | 165 |
7P GAIN MUTATED | 479 | 80 | 8 | 1 | 59 |
7P GAIN WILD-TYPE | 945 | 88 | 1 | 2 | 106 |
P value = 6.56e-14 (Fisher's exact test), Q value = 9.4e-11
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
7P GAIN MUTATED | 356 | 1099 |
7P GAIN WILD-TYPE | 470 | 2638 |
Cluster Labels | 7Q GAIN MUTATED | 7Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 1359 | 3204 |
P value = 0 (logrank test), Q value = 0
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
7Q GAIN MUTATED | 1274 | 559 | 0.0 - 224.0 (11.1) |
7Q GAIN WILD-TYPE | 3022 | 842 | 0.0 - 223.4 (17.2) |
P value = 1.26e-182 (Chi-square test), Q value = 2e-179
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
7Q GAIN MUTATED | 35 | 419 | 115 | 175 | 39 | 50 | 130 | 177 | 0 | 138 | 1 | 78 |
7Q GAIN WILD-TYPE | 90 | 125 | 731 | 237 | 408 | 269 | 363 | 485 | 2 | 410 | 1 | 81 |
P value = 8.98e-27 (Fisher's exact test), Q value = 1.3e-23
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
7Q GAIN MUTATED | 697 | 662 |
7Q GAIN WILD-TYPE | 2184 | 1020 |
P value = 1.03e-38 (Chi-square test), Q value = 1.6e-35
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
7Q GAIN MUTATED | 161 | 14 | 29 | 50 | 130 | 3 | 19 | 56 | 2 | 2 | 3 | 0 | 1 | 0 | 4 | 1 | 0 | 0 | 0 | 86 | 1 | 0 | 77 | 1 | 139 | 9 | 1 | 15 |
7Q GAIN WILD-TYPE | 195 | 40 | 321 | 269 | 363 | 7 | 56 | 149 | 5 | 1 | 12 | 2 | 2 | 2 | 9 | 0 | 1 | 1 | 2 | 229 | 17 | 7 | 66 | 12 | 413 | 70 | 0 | 5 |
P value = 1.08e-08 (Chi-square test), Q value = 1.5e-05
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
7Q GAIN MUTATED | 99 | 186 | 265 | 56 |
7Q GAIN WILD-TYPE | 367 | 446 | 429 | 153 |
P value = 9.32e-07 (Chi-square test), Q value = 0.0013
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 1424 | 168 | 9 | 3 | 165 |
7Q GAIN MUTATED | 421 | 78 | 8 | 1 | 51 |
7Q GAIN WILD-TYPE | 1003 | 90 | 1 | 2 | 114 |
P value = 3.79e-17 (Fisher's exact test), Q value = 5.5e-14
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
7Q GAIN MUTATED | 349 | 1010 |
7Q GAIN WILD-TYPE | 477 | 2727 |
Cluster Labels | 8P GAIN MUTATED | 8P GAIN WILD-TYPE |
---|---|---|
Number of samples | 643 | 3920 |
P value = 4.18e-25 (Chi-square test), Q value = 6.2e-22
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
8P GAIN MUTATED | 17 | 24 | 178 | 74 | 80 | 54 | 14 | 96 | 0 | 80 | 1 | 25 |
8P GAIN WILD-TYPE | 108 | 520 | 668 | 338 | 367 | 265 | 479 | 566 | 2 | 468 | 1 | 134 |
P value = 7.81e-08 (Chi-square test), Q value = 0.00011
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
8P GAIN MUTATED | 64 | 10 | 61 | 54 | 14 | 3 | 11 | 28 | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 49 | 4 | 0 | 23 | 2 | 81 | 15 | 0 | 0 |
8P GAIN WILD-TYPE | 292 | 44 | 289 | 265 | 479 | 7 | 64 | 177 | 5 | 3 | 14 | 2 | 3 | 2 | 12 | 1 | 1 | 0 | 2 | 266 | 14 | 7 | 120 | 11 | 471 | 64 | 1 | 20 |
P value = 2.28e-06 (Chi-square test), Q value = 0.003
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
8P GAIN MUTATED | 26 | 96 | 97 | 35 |
8P GAIN WILD-TYPE | 440 | 536 | 597 | 174 |
Cluster Labels | 8Q GAIN MUTATED | 8Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 1335 | 3228 |
P value = 0.000192 (logrank test), Q value = 0.24
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
8Q GAIN MUTATED | 1223 | 345 | 0.0 - 220.9 (15.1) |
8Q GAIN WILD-TYPE | 3073 | 1056 | 0.0 - 224.0 (14.7) |
P value = 5.25e-86 (Chi-square test), Q value = 8.2e-83
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
8Q GAIN MUTATED | 35 | 28 | 368 | 163 | 103 | 132 | 36 | 208 | 1 | 189 | 2 | 70 |
8Q GAIN WILD-TYPE | 90 | 516 | 478 | 249 | 344 | 187 | 457 | 454 | 1 | 359 | 0 | 89 |
P value = 9.07e-05 (Fisher's exact test), Q value = 0.12
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
8Q GAIN MUTATED | 901 | 434 |
8Q GAIN WILD-TYPE | 1980 | 1248 |
P value = 8.16e-35 (Chi-square test), Q value = 1.2e-31
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
8Q GAIN MUTATED | 149 | 13 | 70 | 132 | 36 | 5 | 25 | 65 | 3 | 0 | 4 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 2 | 100 | 5 | 0 | 65 | 3 | 192 | 28 | 0 | 0 |
8Q GAIN WILD-TYPE | 207 | 41 | 280 | 187 | 457 | 5 | 50 | 140 | 4 | 3 | 11 | 2 | 3 | 2 | 9 | 1 | 1 | 1 | 0 | 215 | 13 | 7 | 78 | 10 | 360 | 51 | 1 | 20 |
P value = 1.08e-14 (Chi-square test), Q value = 1.6e-11
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
8Q GAIN MUTATED | 70 | 207 | 226 | 87 |
8Q GAIN WILD-TYPE | 396 | 425 | 468 | 122 |
P value = 1.34e-07 (Chi-square test), Q value = 0.00018
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 1067 | 353 | 282 | 11 |
8Q GAIN MUTATED | 300 | 123 | 130 | 5 |
8Q GAIN WILD-TYPE | 767 | 230 | 152 | 6 |
P value = 1.98e-09 (Chi-square test), Q value = 2.8e-06
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
8Q GAIN MUTATED | 152 | 163 | 297 | 159 |
8Q GAIN WILD-TYPE | 560 | 335 | 584 | 264 |
P value = 7.22e-06 (Fisher's exact test), Q value = 0.0096
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
8Q GAIN MUTATED | 189 | 1146 |
8Q GAIN WILD-TYPE | 637 | 2591 |
Cluster Labels | 9P GAIN MUTATED | 9P GAIN WILD-TYPE |
---|---|---|
Number of samples | 337 | 4226 |
P value = 8.2e-26 (Chi-square test), Q value = 1.2e-22
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
9P GAIN MUTATED | 14 | 15 | 71 | 48 | 13 | 38 | 8 | 33 | 0 | 62 | 0 | 35 |
9P GAIN WILD-TYPE | 111 | 529 | 775 | 364 | 434 | 281 | 485 | 629 | 2 | 486 | 2 | 124 |
P value = 8.4e-17 (Chi-square test), Q value = 1.2e-13
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
9P GAIN MUTATED | 40 | 8 | 7 | 38 | 8 | 1 | 4 | 6 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 19 | 1 | 0 | 31 | 3 | 62 | 5 | 0 | 1 |
9P GAIN WILD-TYPE | 316 | 46 | 343 | 281 | 485 | 9 | 71 | 199 | 4 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 296 | 17 | 7 | 112 | 10 | 490 | 74 | 1 | 19 |
P value = 3.08e-05 (Chi-square test), Q value = 0.04
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
9P GAIN MUTATED | 16 | 46 | 72 | 25 |
9P GAIN WILD-TYPE | 450 | 586 | 622 | 184 |
Cluster Labels | 9Q GAIN MUTATED | 9Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 284 | 4279 |
P value = 1.21e-23 (Chi-square test), Q value = 1.8e-20
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
9Q GAIN MUTATED | 13 | 26 | 57 | 40 | 4 | 50 | 7 | 34 | 0 | 27 | 0 | 26 |
9Q GAIN WILD-TYPE | 112 | 518 | 789 | 372 | 443 | 269 | 486 | 628 | 2 | 521 | 2 | 133 |
P value = 1.32e-21 (Chi-square test), Q value = 1.9e-18
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
9Q GAIN MUTATED | 34 | 6 | 1 | 50 | 7 | 0 | 2 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 26 | 1 | 0 | 23 | 2 | 27 | 2 | 1 | 1 |
9Q GAIN WILD-TYPE | 322 | 48 | 349 | 269 | 486 | 10 | 73 | 201 | 5 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 289 | 17 | 7 | 120 | 11 | 525 | 77 | 0 | 19 |
P value = 1.94e-07 (Chi-square test), Q value = 0.00027
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
9Q GAIN MUTATED | 14 | 44 | 63 | 32 |
9Q GAIN WILD-TYPE | 452 | 588 | 631 | 177 |
P value = 3.51e-07 (Chi-square test), Q value = 0.00048
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
9Q GAIN MUTATED | 30 | 55 | 45 | 43 |
9Q GAIN WILD-TYPE | 682 | 443 | 836 | 380 |
Cluster Labels | 10P GAIN MUTATED | 10P GAIN WILD-TYPE |
---|---|---|
Number of samples | 454 | 4109 |
P value = 1.17e-58 (Chi-square test), Q value = 1.8e-55
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
10P GAIN MUTATED | 25 | 10 | 108 | 19 | 82 | 13 | 5 | 53 | 0 | 129 | 2 | 8 |
10P GAIN WILD-TYPE | 100 | 534 | 738 | 393 | 365 | 306 | 488 | 609 | 2 | 419 | 0 | 151 |
P value = 2.19e-20 (Fisher's exact test), Q value = 3.2e-17
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
10P GAIN MUTATED | 373 | 81 |
10P GAIN WILD-TYPE | 2508 | 1601 |
P value = 1.7e-37 (Chi-square test), Q value = 2.6e-34
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
10P GAIN MUTATED | 17 | 1 | 69 | 13 | 5 | 1 | 10 | 22 | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 16 | 2 | 0 | 8 | 0 | 131 | 11 | 0 | 0 |
10P GAIN WILD-TYPE | 339 | 53 | 281 | 306 | 488 | 9 | 65 | 183 | 7 | 3 | 15 | 2 | 2 | 2 | 10 | 1 | 1 | 1 | 2 | 299 | 16 | 7 | 135 | 13 | 421 | 68 | 1 | 20 |
P value = 3.16e-13 (Chi-square test), Q value = 4.5e-10
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
10P GAIN MUTATED | 35 | 25 | 130 | 33 |
10P GAIN WILD-TYPE | 677 | 473 | 751 | 390 |
P value = 7.13e-05 (Chi-square test), Q value = 0.092
nPatients | 1 | 2 | 3 | 4 | 5 | CURRENT REFORMED SMOKER FOR < OR = 15 YEARS | CURRENT REFORMED SMOKER FOR > 15 YEARS | CURRENT SMOKER | LIFELONG NON-SMOKER |
---|---|---|---|---|---|---|---|---|---|
ALL | 28 | 23 | 37 | 29 | 2 | 355 | 217 | 250 | 128 |
10P GAIN MUTATED | 5 | 4 | 10 | 4 | 0 | 28 | 17 | 18 | 2 |
10P GAIN WILD-TYPE | 23 | 19 | 27 | 25 | 2 | 327 | 200 | 232 | 126 |
Cluster Labels | 10Q GAIN MUTATED | 10Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 249 | 4314 |
P value = 1.82e-46 (Chi-square test), Q value = 2.8e-43
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
10Q GAIN MUTATED | 7 | 0 | 48 | 8 | 78 | 6 | 3 | 31 | 0 | 63 | 1 | 4 |
10Q GAIN WILD-TYPE | 118 | 544 | 798 | 404 | 369 | 313 | 490 | 631 | 2 | 485 | 1 | 155 |
P value = 3.74e-16 (Fisher's exact test), Q value = 5.4e-13
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
10Q GAIN MUTATED | 214 | 35 |
10Q GAIN WILD-TYPE | 2667 | 1647 |
P value = 3.63e-28 (Chi-square test), Q value = 5.4e-25
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
10Q GAIN MUTATED | 6 | 2 | 66 | 6 | 3 | 1 | 7 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 8 | 2 | 0 | 4 | 0 | 64 | 10 | 0 | 0 |
10Q GAIN WILD-TYPE | 350 | 52 | 284 | 313 | 490 | 9 | 68 | 193 | 7 | 3 | 15 | 2 | 3 | 2 | 10 | 1 | 1 | 1 | 2 | 307 | 16 | 7 | 139 | 13 | 488 | 69 | 1 | 20 |
P value = 8.16e-07 (Chi-square test), Q value = 0.0011
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
10Q GAIN MUTATED | 23 | 12 | 67 | 11 |
10Q GAIN WILD-TYPE | 689 | 486 | 814 | 412 |
Cluster Labels | 11P GAIN MUTATED | 11P GAIN WILD-TYPE |
---|---|---|
Number of samples | 244 | 4319 |
P value = 4.94e-15 (Chi-square test), Q value = 7.1e-12
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
11P GAIN MUTATED | 6 | 3 | 66 | 19 | 6 | 16 | 17 | 50 | 0 | 38 | 1 | 22 |
11P GAIN WILD-TYPE | 119 | 541 | 780 | 393 | 441 | 303 | 476 | 612 | 2 | 510 | 1 | 137 |
P value = 5.54e-06 (Chi-square test), Q value = 0.0074
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
11P GAIN MUTATED | 19 | 0 | 2 | 16 | 17 | 1 | 7 | 17 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 22 | 0 | 0 | 22 | 0 | 39 | 4 | 0 | 0 |
11P GAIN WILD-TYPE | 337 | 54 | 348 | 303 | 476 | 9 | 68 | 188 | 7 | 2 | 15 | 2 | 3 | 2 | 11 | 1 | 1 | 1 | 2 | 293 | 18 | 7 | 121 | 13 | 513 | 75 | 1 | 20 |
Cluster Labels | 11Q GAIN MUTATED | 11Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 264 | 4299 |
P value = 2.5e-16 (Chi-square test), Q value = 3.6e-13
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
11Q GAIN MUTATED | 6 | 6 | 49 | 22 | 7 | 16 | 15 | 66 | 0 | 60 | 0 | 17 |
11Q GAIN WILD-TYPE | 119 | 538 | 797 | 390 | 440 | 303 | 478 | 596 | 2 | 488 | 2 | 142 |
P value = 5.8e-09 (Chi-square test), Q value = 8.1e-06
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
11Q GAIN MUTATED | 22 | 0 | 4 | 16 | 15 | 1 | 7 | 31 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 24 | 0 | 0 | 17 | 0 | 60 | 3 | 0 | 0 |
11Q GAIN WILD-TYPE | 334 | 54 | 346 | 303 | 478 | 9 | 68 | 174 | 6 | 2 | 15 | 2 | 3 | 2 | 12 | 1 | 1 | 1 | 2 | 291 | 18 | 7 | 126 | 13 | 492 | 76 | 1 | 20 |
P value = 8.26e-05 (t-test), Q value = 0.11
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 568 | 1995.2 (13.5) |
11Q GAIN MUTATED | 51 | 2001.3 (10.6) |
11Q GAIN WILD-TYPE | 517 | 1994.6 (13.6) |
Cluster Labels | 12P GAIN MUTATED | 12P GAIN WILD-TYPE |
---|---|---|
Number of samples | 765 | 3798 |
P value = 1.45e-43 (Chi-square test), Q value = 2.2e-40
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
12P GAIN MUTATED | 22 | 35 | 113 | 67 | 33 | 61 | 78 | 131 | 0 | 195 | 2 | 28 |
12P GAIN WILD-TYPE | 103 | 509 | 733 | 345 | 414 | 258 | 415 | 531 | 2 | 353 | 0 | 131 |
P value = 4.59e-25 (Chi-square test), Q value = 6.8e-22
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
12P GAIN MUTATED | 58 | 8 | 19 | 61 | 78 | 0 | 9 | 29 | 2 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 88 | 1 | 1 | 26 | 2 | 197 | 13 | 0 | 1 |
12P GAIN WILD-TYPE | 298 | 46 | 331 | 258 | 415 | 10 | 66 | 176 | 5 | 3 | 15 | 1 | 3 | 2 | 12 | 1 | 1 | 1 | 2 | 227 | 17 | 6 | 117 | 11 | 355 | 66 | 1 | 19 |
P value = 9.68e-09 (Chi-square test), Q value = 1.3e-05
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
12P GAIN MUTATED | 109 | 111 | 248 | 81 |
12P GAIN WILD-TYPE | 603 | 387 | 633 | 342 |
P value = 4.22e-07 (Fisher's exact test), Q value = 0.00057
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
12P GAIN MUTATED | 91 | 674 |
12P GAIN WILD-TYPE | 735 | 3063 |
Cluster Labels | 12Q GAIN MUTATED | 12Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 525 | 4038 |
P value = 7.1e-15 (Chi-square test), Q value = 1e-11
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
12Q GAIN MUTATED | 17 | 26 | 88 | 60 | 26 | 26 | 79 | 79 | 0 | 105 | 1 | 18 |
12Q GAIN WILD-TYPE | 108 | 518 | 758 | 352 | 421 | 293 | 414 | 583 | 2 | 443 | 1 | 141 |
P value = 6.49e-05 (Chi-square test), Q value = 0.084
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
12Q GAIN MUTATED | 50 | 9 | 18 | 26 | 79 | 1 | 7 | 23 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 43 | 1 | 1 | 17 | 1 | 106 | 7 | 0 | 1 |
12Q GAIN WILD-TYPE | 306 | 45 | 332 | 293 | 414 | 9 | 68 | 182 | 6 | 3 | 15 | 1 | 3 | 2 | 12 | 1 | 1 | 1 | 1 | 272 | 17 | 6 | 126 | 12 | 446 | 72 | 1 | 19 |
Cluster Labels | 13Q GAIN MUTATED | 13Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 491 | 4072 |
P value = 6.48e-11 (t-test), Q value = 9.2e-08
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 4507 | 61.9 (12.6) |
13Q GAIN MUTATED | 489 | 65.2 (11.9) |
13Q GAIN WILD-TYPE | 4018 | 61.4 (12.7) |
P value = 3.03e-280 (Chi-square test), Q value = 4.8e-277
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
13Q GAIN MUTATED | 21 | 1 | 46 | 211 | 19 | 18 | 12 | 24 | 0 | 38 | 0 | 98 |
13Q GAIN WILD-TYPE | 104 | 543 | 800 | 201 | 428 | 301 | 481 | 638 | 2 | 510 | 2 | 61 |
P value = 3.06e-05 (Fisher's exact test), Q value = 0.04
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
13Q GAIN MUTATED | 267 | 224 |
13Q GAIN WILD-TYPE | 2614 | 1458 |
P value = 2.32e-211 (Chi-square test), Q value = 3.7e-208
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
13Q GAIN MUTATED | 199 | 12 | 6 | 18 | 12 | 0 | 4 | 8 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 9 | 1 | 0 | 95 | 2 | 38 | 12 | 0 | 0 |
13Q GAIN WILD-TYPE | 157 | 42 | 344 | 301 | 481 | 10 | 71 | 197 | 7 | 3 | 15 | 1 | 3 | 2 | 12 | 1 | 1 | 0 | 2 | 306 | 17 | 7 | 48 | 11 | 514 | 67 | 1 | 20 |
P value = 1.2e-34 (Chi-square test), Q value = 1.8e-31
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
13Q GAIN MUTATED | 20 | 79 | 220 | 44 |
13Q GAIN WILD-TYPE | 446 | 553 | 474 | 165 |
P value = 1.68e-06 (Chi-square test), Q value = 0.0023
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 1067 | 353 | 282 | 11 |
13Q GAIN MUTATED | 177 | 101 | 68 | 0 |
13Q GAIN WILD-TYPE | 890 | 252 | 214 | 11 |
P value = 1.36e-05 (Chi-square test), Q value = 0.018
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 1424 | 168 | 9 | 3 | 165 |
13Q GAIN MUTATED | 258 | 51 | 6 | 0 | 31 |
13Q GAIN WILD-TYPE | 1166 | 117 | 3 | 3 | 134 |
P value = 7.91e-08 (Chi-square test), Q value = 0.00011
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
13Q GAIN MUTATED | 66 | 107 | 147 | 67 |
13Q GAIN WILD-TYPE | 646 | 391 | 734 | 356 |
P value = 9.57e-15 (Fisher's exact test), Q value = 1.4e-11
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
13Q GAIN MUTATED | 32 | 459 |
13Q GAIN WILD-TYPE | 794 | 3278 |
P value = 5.18e-07 (Chi-square test), Q value = 7e-04
nPatients | 1 | 2 | 3 | 4 | 5 | CURRENT REFORMED SMOKER FOR < OR = 15 YEARS | CURRENT REFORMED SMOKER FOR > 15 YEARS | CURRENT SMOKER | LIFELONG NON-SMOKER |
---|---|---|---|---|---|---|---|---|---|
ALL | 28 | 23 | 37 | 29 | 2 | 355 | 217 | 250 | 128 |
13Q GAIN MUTATED | 4 | 6 | 6 | 4 | 1 | 13 | 13 | 10 | 5 |
13Q GAIN WILD-TYPE | 24 | 17 | 31 | 25 | 1 | 342 | 204 | 240 | 123 |
P value = 2.95e-05 (Chi-square test), Q value = 0.038
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 1171 | 69 | 59 | 77 |
13Q GAIN MUTATED | 254 | 5 | 24 | 11 |
13Q GAIN WILD-TYPE | 917 | 64 | 35 | 66 |
Cluster Labels | 14Q GAIN MUTATED | 14Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 294 | 4269 |
P value = 7.71e-29 (Chi-square test), Q value = 1.2e-25
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
14Q GAIN MUTATED | 10 | 4 | 77 | 15 | 16 | 53 | 5 | 76 | 0 | 33 | 0 | 5 |
14Q GAIN WILD-TYPE | 115 | 540 | 769 | 397 | 431 | 266 | 488 | 586 | 2 | 515 | 2 | 154 |
P value = 4.79e-21 (Chi-square test), Q value = 7e-18
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
14Q GAIN MUTATED | 12 | 3 | 9 | 53 | 5 | 2 | 5 | 30 | 1 | 1 | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 1 | 33 | 0 | 0 | 5 | 0 | 33 | 7 | 1 | 0 |
14Q GAIN WILD-TYPE | 344 | 51 | 341 | 266 | 488 | 8 | 70 | 175 | 6 | 2 | 15 | 2 | 2 | 2 | 11 | 1 | 1 | 1 | 1 | 282 | 18 | 7 | 138 | 13 | 519 | 72 | 0 | 20 |
Cluster Labels | 15Q GAIN MUTATED | 15Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 155 | 4408 |
P value = 4.82e-08 (Chi-square test), Q value = 6.7e-05
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
15Q GAIN MUTATED | 4 | 3 | 43 | 5 | 5 | 14 | 14 | 43 | 0 | 21 | 0 | 3 |
15Q GAIN WILD-TYPE | 121 | 541 | 803 | 407 | 442 | 305 | 479 | 619 | 2 | 527 | 2 | 156 |
P value = 5.1e-07 (Chi-square test), Q value = 7e-04
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
15Q GAIN MUTATED | 5 | 0 | 4 | 14 | 14 | 1 | 3 | 5 | 2 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 30 | 0 | 0 | 2 | 1 | 21 | 1 | 0 | 0 |
15Q GAIN WILD-TYPE | 351 | 54 | 346 | 305 | 479 | 9 | 72 | 200 | 5 | 2 | 15 | 2 | 3 | 2 | 12 | 1 | 1 | 1 | 2 | 285 | 18 | 7 | 141 | 12 | 531 | 78 | 1 | 20 |
P value = 0.00018 (Chi-square test), Q value = 0.23
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
15Q GAIN MUTATED | 15 | 40 | 12 | 8 |
15Q GAIN WILD-TYPE | 451 | 592 | 682 | 201 |
Cluster Labels | 16P GAIN MUTATED | 16P GAIN WILD-TYPE |
---|---|---|
Number of samples | 569 | 3994 |
P value = 2.01e-09 (logrank test), Q value = 2.8e-06
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
16P GAIN MUTATED | 529 | 109 | 0.0 - 224.0 (15.0) |
16P GAIN WILD-TYPE | 3767 | 1292 | 0.0 - 220.9 (14.9) |
P value = 1.31e-70 (Chi-square test), Q value = 2e-67
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
16P GAIN MUTATED | 11 | 14 | 249 | 68 | 11 | 24 | 65 | 66 | 0 | 31 | 0 | 29 |
16P GAIN WILD-TYPE | 114 | 530 | 597 | 344 | 436 | 295 | 428 | 596 | 2 | 517 | 2 | 130 |
P value = 1.28e-06 (Fisher's exact test), Q value = 0.0017
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
16P GAIN MUTATED | 411 | 158 |
16P GAIN WILD-TYPE | 2470 | 1524 |
P value = 4.74e-17 (Chi-square test), Q value = 6.9e-14
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
16P GAIN MUTATED | 65 | 3 | 5 | 24 | 65 | 3 | 7 | 34 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 16 | 0 | 1 | 29 | 0 | 31 | 6 | 0 | 0 |
16P GAIN WILD-TYPE | 291 | 51 | 345 | 295 | 428 | 7 | 68 | 171 | 6 | 3 | 14 | 2 | 2 | 2 | 12 | 1 | 1 | 0 | 2 | 299 | 18 | 6 | 114 | 13 | 521 | 73 | 1 | 20 |
Cluster Labels | 16Q GAIN MUTATED | 16Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 334 | 4229 |
P value = 2.54e-28 (Chi-square test), Q value = 3.8e-25
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
16Q GAIN MUTATED | 13 | 14 | 53 | 66 | 4 | 27 | 58 | 53 | 0 | 15 | 0 | 30 |
16Q GAIN WILD-TYPE | 112 | 530 | 793 | 346 | 443 | 292 | 435 | 609 | 2 | 533 | 2 | 129 |
P value = 1.06e-21 (Chi-square test), Q value = 1.6e-18
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
16Q GAIN MUTATED | 63 | 3 | 3 | 27 | 58 | 2 | 1 | 24 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 21 | 0 | 1 | 30 | 0 | 15 | 1 | 0 | 0 |
16Q GAIN WILD-TYPE | 293 | 51 | 347 | 292 | 435 | 8 | 74 | 181 | 7 | 3 | 14 | 2 | 2 | 2 | 12 | 1 | 1 | 0 | 2 | 294 | 18 | 6 | 113 | 13 | 537 | 78 | 1 | 20 |
P value = 4.1e-06 (Fisher's exact test), Q value = 0.0055
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
16Q GAIN MUTATED | 31 | 303 |
16Q GAIN WILD-TYPE | 795 | 3434 |
Cluster Labels | 17P GAIN MUTATED | 17P GAIN WILD-TYPE |
---|---|---|
Number of samples | 166 | 4397 |
P value = 1.5e-06 (Chi-square test), Q value = 0.002
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
17P GAIN MUTATED | 10 | 9 | 50 | 11 | 6 | 19 | 16 | 32 | 0 | 9 | 0 | 4 |
17P GAIN WILD-TYPE | 115 | 535 | 796 | 401 | 441 | 300 | 477 | 630 | 2 | 539 | 2 | 155 |
P value = 9.33e-07 (Chi-square test), Q value = 0.0013
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
17P GAIN MUTATED | 11 | 0 | 4 | 19 | 16 | 1 | 5 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 11 | 0 | 0 | 4 | 0 | 9 | 2 | 0 | 1 |
17P GAIN WILD-TYPE | 345 | 54 | 346 | 300 | 477 | 9 | 70 | 192 | 7 | 3 | 15 | 2 | 3 | 1 | 13 | 0 | 1 | 1 | 2 | 304 | 18 | 7 | 139 | 13 | 543 | 77 | 1 | 19 |
Cluster Labels | 17Q GAIN MUTATED | 17Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 405 | 4158 |
P value = 3.22e-30 (Chi-square test), Q value = 4.8e-27
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
17Q GAIN MUTATED | 23 | 17 | 126 | 48 | 10 | 23 | 22 | 100 | 0 | 19 | 0 | 17 |
17Q GAIN WILD-TYPE | 102 | 527 | 720 | 364 | 437 | 296 | 471 | 562 | 2 | 529 | 2 | 142 |
P value = 1.46e-19 (Chi-square test), Q value = 2.1e-16
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
17Q GAIN MUTATED | 45 | 2 | 7 | 23 | 22 | 2 | 14 | 40 | 2 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 38 | 0 | 0 | 17 | 0 | 19 | 3 | 1 | 2 |
17Q GAIN WILD-TYPE | 311 | 52 | 343 | 296 | 471 | 8 | 61 | 165 | 5 | 3 | 15 | 1 | 3 | 1 | 12 | 1 | 1 | 1 | 1 | 277 | 18 | 7 | 126 | 13 | 533 | 76 | 0 | 18 |
Cluster Labels | 18P GAIN MUTATED | 18P GAIN WILD-TYPE |
---|---|---|
Number of samples | 419 | 4144 |
P value = 9.68e-18 (Chi-square test), Q value = 1.4e-14
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
18P GAIN MUTATED | 19 | 26 | 85 | 15 | 33 | 53 | 18 | 88 | 0 | 75 | 0 | 7 |
18P GAIN WILD-TYPE | 106 | 518 | 761 | 397 | 414 | 266 | 475 | 574 | 2 | 473 | 2 | 152 |
P value = 2.74e-20 (Chi-square test), Q value = 4e-17
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
18P GAIN MUTATED | 10 | 5 | 11 | 53 | 18 | 4 | 8 | 18 | 3 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 53 | 2 | 0 | 6 | 1 | 75 | 20 | 0 | 1 |
18P GAIN WILD-TYPE | 346 | 49 | 339 | 266 | 475 | 6 | 67 | 187 | 4 | 3 | 15 | 2 | 3 | 2 | 11 | 1 | 1 | 1 | 2 | 262 | 16 | 7 | 137 | 12 | 477 | 59 | 1 | 19 |
Cluster Labels | 18Q GAIN MUTATED | 18Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 288 | 4275 |
P value = 6.25e-08 (Chi-square test), Q value = 8.6e-05
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
18Q GAIN MUTATED | 7 | 27 | 78 | 9 | 16 | 23 | 18 | 63 | 0 | 43 | 0 | 4 |
18Q GAIN WILD-TYPE | 118 | 517 | 768 | 403 | 431 | 296 | 475 | 599 | 2 | 505 | 2 | 155 |
P value = 4.22e-08 (Chi-square test), Q value = 5.8e-05
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
18Q GAIN MUTATED | 6 | 3 | 7 | 23 | 18 | 2 | 5 | 12 | 3 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 39 | 2 | 0 | 4 | 0 | 43 | 7 | 0 | 1 |
18Q GAIN WILD-TYPE | 350 | 51 | 343 | 296 | 475 | 8 | 70 | 193 | 4 | 3 | 15 | 2 | 3 | 2 | 11 | 1 | 1 | 1 | 2 | 276 | 16 | 7 | 139 | 13 | 509 | 72 | 1 | 19 |
P value = 0.00019 (Chi-square test), Q value = 0.24
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
18Q GAIN MUTATED | 23 | 54 | 21 | 12 |
18Q GAIN WILD-TYPE | 443 | 578 | 673 | 197 |
Cluster Labels | 19P GAIN MUTATED | 19P GAIN WILD-TYPE |
---|---|---|
Number of samples | 503 | 4060 |
P value = 1.12e-08 (logrank test), Q value = 1.6e-05
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
19P GAIN MUTATED | 485 | 210 | 0.0 - 180.2 (13.3) |
19P GAIN WILD-TYPE | 3811 | 1191 | 0.0 - 224.0 (15.0) |
P value = 5.15e-56 (Chi-square test), Q value = 8e-53
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
19P GAIN MUTATED | 13 | 167 | 69 | 34 | 27 | 15 | 24 | 48 | 0 | 87 | 0 | 19 |
19P GAIN WILD-TYPE | 112 | 377 | 777 | 378 | 420 | 304 | 469 | 614 | 2 | 461 | 2 | 140 |
P value = 1.97e-20 (Chi-square test), Q value = 2.9e-17
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
19P GAIN MUTATED | 33 | 1 | 12 | 15 | 24 | 0 | 1 | 10 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 32 | 0 | 0 | 19 | 0 | 87 | 15 | 1 | 6 |
19P GAIN WILD-TYPE | 323 | 53 | 338 | 304 | 469 | 10 | 74 | 195 | 2 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 283 | 18 | 7 | 124 | 13 | 465 | 64 | 0 | 14 |
P value = 3.56e-13 (Fisher's exact test), Q value = 5.1e-10
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
19P GAIN MUTATED | 154 | 349 |
19P GAIN WILD-TYPE | 672 | 3388 |
Cluster Labels | 19Q GAIN MUTATED | 19Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 536 | 4027 |
P value = 4.08e-08 (logrank test), Q value = 5.6e-05
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
19Q GAIN MUTATED | 513 | 210 | 0.0 - 180.2 (12.6) |
19Q GAIN WILD-TYPE | 3783 | 1191 | 0.0 - 224.0 (15.1) |
P value = 3.05e-30 (Chi-square test), Q value = 4.6e-27
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
19Q GAIN MUTATED | 25 | 142 | 84 | 41 | 24 | 21 | 28 | 72 | 0 | 76 | 0 | 23 |
19Q GAIN WILD-TYPE | 100 | 402 | 762 | 371 | 423 | 298 | 465 | 590 | 2 | 472 | 2 | 136 |
P value = 1.2e-15 (Chi-square test), Q value = 1.7e-12
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
19Q GAIN MUTATED | 37 | 4 | 7 | 21 | 28 | 0 | 3 | 18 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 46 | 0 | 0 | 23 | 0 | 76 | 17 | 1 | 3 |
19Q GAIN WILD-TYPE | 319 | 50 | 343 | 298 | 465 | 10 | 72 | 187 | 2 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 269 | 18 | 7 | 120 | 13 | 476 | 62 | 0 | 17 |
P value = 1.22e-05 (Fisher's exact test), Q value = 0.016
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
19Q GAIN MUTATED | 135 | 401 |
19Q GAIN WILD-TYPE | 691 | 3336 |
Cluster Labels | 20P GAIN MUTATED | 20P GAIN WILD-TYPE |
---|---|---|
Number of samples | 1300 | 3263 |
P value = 4.13e-05 (logrank test), Q value = 0.054
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
20P GAIN MUTATED | 1200 | 433 | 0.0 - 224.0 (13.1) |
20P GAIN WILD-TYPE | 3096 | 968 | 0.0 - 223.4 (15.1) |
P value = 7.61e-09 (t-test), Q value = 1.1e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 4507 | 61.9 (12.6) |
20P GAIN MUTATED | 1289 | 63.5 (12.3) |
20P GAIN WILD-TYPE | 3218 | 61.2 (12.7) |
P value = 1.84e-64 (Chi-square test), Q value = 2.9e-61
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
20P GAIN MUTATED | 48 | 174 | 233 | 197 | 52 | 64 | 66 | 148 | 1 | 223 | 1 | 91 |
20P GAIN WILD-TYPE | 77 | 370 | 613 | 215 | 395 | 255 | 427 | 514 | 1 | 325 | 1 | 68 |
P value = 2.23e-68 (Chi-square test), Q value = 3.5e-65
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
20P GAIN MUTATED | 182 | 13 | 26 | 64 | 66 | 2 | 11 | 34 | 5 | 1 | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 1 | 0 | 91 | 3 | 0 | 87 | 2 | 225 | 23 | 1 | 7 |
20P GAIN WILD-TYPE | 174 | 41 | 324 | 255 | 427 | 8 | 64 | 171 | 2 | 2 | 15 | 2 | 2 | 2 | 11 | 1 | 1 | 0 | 2 | 224 | 15 | 7 | 56 | 11 | 327 | 56 | 0 | 13 |
P value = 6.36e-14 (Chi-square test), Q value = 9.1e-11
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
20P GAIN MUTATED | 71 | 171 | 255 | 59 |
20P GAIN WILD-TYPE | 395 | 461 | 439 | 150 |
P value = 9.41e-06 (Chi-square test), Q value = 0.012
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 1424 | 168 | 9 | 3 | 165 |
20P GAIN MUTATED | 387 | 66 | 8 | 0 | 43 |
20P GAIN WILD-TYPE | 1037 | 102 | 1 | 3 | 122 |
P value = 2.76e-07 (Chi-square test), Q value = 0.00038
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
20P GAIN MUTATED | 160 | 153 | 315 | 132 |
20P GAIN WILD-TYPE | 552 | 345 | 566 | 291 |
P value = 6.9e-06 (Chi-square test), Q value = 0.0092
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 1171 | 69 | 59 | 77 |
20P GAIN MUTATED | 342 | 15 | 33 | 14 |
20P GAIN WILD-TYPE | 829 | 54 | 26 | 63 |
Cluster Labels | 20Q GAIN MUTATED | 20Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 1509 | 3054 |
P value = 3.39e-07 (t-test), Q value = 0.00046
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 4507 | 61.9 (12.6) |
20Q GAIN MUTATED | 1498 | 63.2 (12.4) |
20Q GAIN WILD-TYPE | 3009 | 61.2 (12.7) |
P value = 1.97e-130 (Chi-square test), Q value = 3.1e-127
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
20Q GAIN MUTATED | 52 | 171 | 271 | 267 | 60 | 68 | 68 | 151 | 1 | 264 | 1 | 132 |
20Q GAIN WILD-TYPE | 73 | 373 | 575 | 145 | 387 | 251 | 425 | 511 | 1 | 284 | 1 | 27 |
P value = 1.03e-135 (Chi-square test), Q value = 1.6e-132
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
20Q GAIN MUTATED | 249 | 16 | 27 | 68 | 68 | 3 | 14 | 44 | 5 | 1 | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 1 | 1 | 79 | 3 | 0 | 125 | 5 | 266 | 30 | 1 | 6 |
20Q GAIN WILD-TYPE | 107 | 38 | 323 | 251 | 425 | 7 | 61 | 161 | 2 | 2 | 15 | 2 | 2 | 2 | 11 | 1 | 1 | 0 | 1 | 236 | 15 | 7 | 18 | 8 | 286 | 49 | 0 | 14 |
P value = 5.56e-29 (Chi-square test), Q value = 8.3e-26
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
20Q GAIN MUTATED | 74 | 198 | 336 | 71 |
20Q GAIN WILD-TYPE | 392 | 434 | 358 | 138 |
P value = 2.83e-15 (Chi-square test), Q value = 4.1e-12
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
20Q GAIN MUTATED | 176 | 199 | 394 | 152 |
20Q GAIN WILD-TYPE | 536 | 299 | 487 | 271 |
P value = 8.01e-06 (Chi-square test), Q value = 0.011
nPatients | 1 | 2 | 3 | 4 | 5 | CURRENT REFORMED SMOKER FOR < OR = 15 YEARS | CURRENT REFORMED SMOKER FOR > 15 YEARS | CURRENT SMOKER | LIFELONG NON-SMOKER |
---|---|---|---|---|---|---|---|---|---|
ALL | 28 | 23 | 37 | 29 | 2 | 355 | 217 | 250 | 128 |
20Q GAIN MUTATED | 7 | 12 | 15 | 17 | 0 | 91 | 43 | 54 | 27 |
20Q GAIN WILD-TYPE | 21 | 11 | 22 | 12 | 2 | 264 | 174 | 196 | 101 |
P value = 9.3e-07 (Chi-square test), Q value = 0.0013
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 1171 | 69 | 59 | 77 |
20Q GAIN MUTATED | 428 | 19 | 40 | 20 |
20Q GAIN WILD-TYPE | 743 | 50 | 19 | 57 |
Cluster Labels | 21Q GAIN MUTATED | 21Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 347 | 4216 |
P value = 1.66e-15 (Chi-square test), Q value = 2.4e-12
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
21Q GAIN MUTATED | 23 | 31 | 98 | 11 | 20 | 8 | 33 | 51 | 0 | 63 | 1 | 7 |
21Q GAIN WILD-TYPE | 102 | 513 | 748 | 401 | 427 | 311 | 460 | 611 | 2 | 485 | 1 | 152 |
P value = 4.02e-10 (Chi-square test), Q value = 5.7e-07
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
21Q GAIN MUTATED | 10 | 1 | 9 | 8 | 33 | 1 | 5 | 24 | 2 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 16 | 0 | 0 | 7 | 0 | 64 | 11 | 0 | 1 |
21Q GAIN WILD-TYPE | 346 | 53 | 341 | 311 | 460 | 9 | 70 | 181 | 5 | 3 | 15 | 2 | 2 | 2 | 12 | 1 | 1 | 0 | 2 | 299 | 18 | 7 | 136 | 13 | 488 | 68 | 1 | 19 |
P value = 1.61e-05 (Chi-square test), Q value = 0.021
nPatients | 1 | 2 | 3 | 4 | 5 | CURRENT REFORMED SMOKER FOR < OR = 15 YEARS | CURRENT REFORMED SMOKER FOR > 15 YEARS | CURRENT SMOKER | LIFELONG NON-SMOKER |
---|---|---|---|---|---|---|---|---|---|
ALL | 28 | 23 | 37 | 29 | 2 | 355 | 217 | 250 | 128 |
21Q GAIN MUTATED | 6 | 2 | 8 | 7 | 0 | 23 | 13 | 10 | 12 |
21Q GAIN WILD-TYPE | 22 | 21 | 29 | 22 | 2 | 332 | 204 | 240 | 116 |
Cluster Labels | 22Q GAIN MUTATED | 22Q GAIN WILD-TYPE |
---|---|---|
Number of samples | 240 | 4323 |
P value = 4.2e-36 (Chi-square test), Q value = 6.3e-33
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
22Q GAIN MUTATED | 11 | 11 | 38 | 2 | 6 | 39 | 25 | 93 | 0 | 10 | 0 | 5 |
22Q GAIN WILD-TYPE | 114 | 533 | 808 | 410 | 441 | 280 | 468 | 569 | 2 | 538 | 2 | 154 |
P value = 2.26e-09 (Fisher's exact test), Q value = 3.2e-06
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
22Q GAIN MUTATED | 107 | 133 |
22Q GAIN WILD-TYPE | 2774 | 1549 |
P value = 1.24e-43 (Chi-square test), Q value = 1.9e-40
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
22Q GAIN MUTATED | 2 | 0 | 2 | 39 | 25 | 0 | 1 | 15 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 74 | 0 | 0 | 5 | 0 | 10 | 4 | 0 | 0 |
22Q GAIN WILD-TYPE | 354 | 54 | 348 | 280 | 468 | 10 | 74 | 190 | 5 | 3 | 15 | 2 | 2 | 2 | 13 | 1 | 1 | 1 | 2 | 241 | 18 | 7 | 138 | 13 | 542 | 75 | 1 | 20 |
P value = 5.6e-07 (Chi-square test), Q value = 0.00076
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
22Q GAIN MUTATED | 26 | 79 | 33 | 19 |
22Q GAIN WILD-TYPE | 440 | 553 | 661 | 190 |
Cluster Labels | XQ GAIN MUTATED | XQ GAIN WILD-TYPE |
---|---|---|
Number of samples | 149 | 4414 |
P value = 2.22e-08 (Chi-square test), Q value = 3.1e-05
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
XQ GAIN MUTATED | 8 | 3 | 21 | 11 | 8 | 20 | 7 | 29 | 0 | 36 | 0 | 6 |
XQ GAIN WILD-TYPE | 117 | 541 | 825 | 401 | 439 | 299 | 486 | 633 | 2 | 512 | 2 | 153 |
Cluster Labels | 1P LOSS MUTATED | 1P LOSS WILD-TYPE |
---|---|---|
Number of samples | 351 | 4212 |
P value = 4.3e-20 (Chi-square test), Q value = 6.3e-17
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
1P LOSS MUTATED | 2 | 9 | 113 | 49 | 11 | 15 | 31 | 62 | 0 | 36 | 0 | 22 |
1P LOSS WILD-TYPE | 123 | 535 | 733 | 363 | 436 | 304 | 462 | 600 | 2 | 512 | 2 | 137 |
P value = 4.74e-08 (Chi-square test), Q value = 6.6e-05
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
1P LOSS MUTATED | 46 | 3 | 5 | 15 | 31 | 1 | 6 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 40 | 2 | 1 | 21 | 0 | 36 | 4 | 0 | 0 |
1P LOSS WILD-TYPE | 310 | 51 | 345 | 304 | 462 | 9 | 69 | 194 | 7 | 3 | 15 | 2 | 3 | 2 | 11 | 0 | 1 | 1 | 2 | 275 | 16 | 6 | 122 | 13 | 516 | 75 | 1 | 20 |
P value = 1.07e-05 (Chi-square test), Q value = 0.014
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE TIS | STAGE X |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 72 | 62 | 7 | 43 | 287 | 186 | 42 | 124 | 25 | 41 | 59 | 1 | 16 |
1P LOSS MUTATED | 4 | 5 | 0 | 1 | 36 | 19 | 1 | 21 | 11 | 7 | 5 | 0 | 4 |
1P LOSS WILD-TYPE | 68 | 57 | 7 | 42 | 251 | 167 | 41 | 103 | 14 | 34 | 54 | 1 | 12 |
Cluster Labels | 1Q LOSS MUTATED | 1Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 112 | 4451 |
Cluster Labels | 2P LOSS MUTATED | 2P LOSS WILD-TYPE |
---|---|---|
Number of samples | 148 | 4415 |
P value = 6.03e-17 (Chi-square test), Q value = 8.8e-14
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
2P LOSS MUTATED | 6 | 13 | 69 | 4 | 5 | 6 | 10 | 4 | 0 | 24 | 0 | 7 |
2P LOSS WILD-TYPE | 119 | 531 | 777 | 408 | 442 | 313 | 483 | 658 | 2 | 524 | 2 | 152 |
P value = 6.09e-05 (Fisher's exact test), Q value = 0.079
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
2P LOSS MUTATED | 116 | 32 |
2P LOSS WILD-TYPE | 2765 | 1650 |
Cluster Labels | 2Q LOSS MUTATED | 2Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 188 | 4375 |
P value = 2.8e-22 (Chi-square test), Q value = 4.1e-19
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
2Q LOSS MUTATED | 13 | 12 | 83 | 6 | 7 | 11 | 11 | 11 | 0 | 28 | 1 | 5 |
2Q LOSS WILD-TYPE | 112 | 532 | 763 | 406 | 440 | 308 | 482 | 651 | 2 | 520 | 1 | 154 |
P value = 1.65e-05 (Chi-square test), Q value = 0.022
nPatients | 1 | 2 | 3 | 4 | 5 | CURRENT REFORMED SMOKER FOR < OR = 15 YEARS | CURRENT REFORMED SMOKER FOR > 15 YEARS | CURRENT SMOKER | LIFELONG NON-SMOKER |
---|---|---|---|---|---|---|---|---|---|
ALL | 28 | 23 | 37 | 29 | 2 | 355 | 217 | 250 | 128 |
2Q LOSS MUTATED | 3 | 1 | 4 | 4 | 0 | 4 | 1 | 11 | 4 |
2Q LOSS WILD-TYPE | 25 | 22 | 33 | 25 | 2 | 351 | 216 | 239 | 124 |
Cluster Labels | 3P LOSS MUTATED | 3P LOSS WILD-TYPE |
---|---|---|
Number of samples | 868 | 3695 |
P value = 1.29e-218 (Chi-square test), Q value = 2.1e-215
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
3P LOSS MUTATED | 7 | 25 | 85 | 28 | 26 | 121 | 318 | 193 | 1 | 56 | 0 | 8 |
3P LOSS WILD-TYPE | 118 | 519 | 761 | 384 | 421 | 198 | 175 | 469 | 1 | 492 | 2 | 151 |
P value = 7.17e-34 (Fisher's exact test), Q value = 1.1e-30
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
3P LOSS MUTATED | 390 | 478 |
3P LOSS WILD-TYPE | 2491 | 1204 |
P value = 3.19e-144 (Chi-square test), Q value = 5e-141
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
3P LOSS MUTATED | 27 | 1 | 11 | 121 | 318 | 3 | 17 | 44 | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 1 | 0 | 122 | 4 | 1 | 5 | 2 | 57 | 11 | 0 | 1 |
3P LOSS WILD-TYPE | 329 | 53 | 339 | 198 | 175 | 7 | 58 | 161 | 6 | 3 | 14 | 2 | 3 | 2 | 11 | 0 | 1 | 0 | 2 | 193 | 14 | 6 | 138 | 11 | 495 | 68 | 1 | 19 |
P value = 5.56e-14 (Chi-square test), Q value = 8e-11
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
3P LOSS MUTATED | 222 | 183 | 189 | 55 |
3P LOSS WILD-TYPE | 244 | 449 | 505 | 154 |
P value = 0.00016 (Chi-square test), Q value = 0.2
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 1424 | 168 | 9 | 3 | 165 |
3P LOSS MUTATED | 469 | 57 | 1 | 0 | 27 |
3P LOSS WILD-TYPE | 955 | 111 | 8 | 3 | 138 |
P value = 4.02e-13 (Chi-square test), Q value = 5.7e-10
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
3P LOSS MUTATED | 268 | 116 | 186 | 130 |
3P LOSS WILD-TYPE | 444 | 382 | 695 | 293 |
P value = 2.88e-11 (Fisher's exact test), Q value = 4.1e-08
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
3P LOSS MUTATED | 92 | 776 |
3P LOSS WILD-TYPE | 734 | 2961 |
P value = 5.35e-08 (Chi-square test), Q value = 7.4e-05
nPatients | 1 | 2 | 3 | 4 | 5 | CURRENT REFORMED SMOKER FOR < OR = 15 YEARS | CURRENT REFORMED SMOKER FOR > 15 YEARS | CURRENT SMOKER | LIFELONG NON-SMOKER |
---|---|---|---|---|---|---|---|---|---|
ALL | 28 | 23 | 37 | 29 | 2 | 355 | 217 | 250 | 128 |
3P LOSS MUTATED | 0 | 1 | 4 | 1 | 0 | 121 | 61 | 93 | 29 |
3P LOSS WILD-TYPE | 28 | 22 | 33 | 28 | 2 | 234 | 156 | 157 | 99 |
Cluster Labels | 3Q LOSS MUTATED | 3Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 291 | 4272 |
P value = 6.51e-39 (Chi-square test), Q value = 9.9e-36
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
3Q LOSS MUTATED | 1 | 20 | 41 | 13 | 12 | 21 | 97 | 63 | 1 | 18 | 0 | 4 |
3Q LOSS WILD-TYPE | 124 | 524 | 805 | 399 | 435 | 298 | 396 | 599 | 1 | 530 | 2 | 155 |
P value = 2.54e-09 (Fisher's exact test), Q value = 3.6e-06
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
3Q LOSS MUTATED | 135 | 156 |
3Q LOSS WILD-TYPE | 2746 | 1526 |
P value = 3.54e-28 (Chi-square test), Q value = 5.3e-25
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
3Q LOSS MUTATED | 13 | 0 | 6 | 21 | 97 | 3 | 10 | 26 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 21 | 0 | 0 | 1 | 3 | 19 | 6 | 0 | 0 |
3Q LOSS WILD-TYPE | 343 | 54 | 344 | 298 | 396 | 7 | 65 | 179 | 7 | 3 | 14 | 2 | 3 | 2 | 12 | 0 | 1 | 1 | 2 | 294 | 18 | 7 | 142 | 10 | 533 | 73 | 1 | 20 |
Cluster Labels | 4P LOSS MUTATED | 4P LOSS WILD-TYPE |
---|---|---|
Number of samples | 917 | 3646 |
P value = 1.58e-69 (Chi-square test), Q value = 2.5e-66
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
4P LOSS MUTATED | 22 | 29 | 174 | 85 | 47 | 77 | 35 | 169 | 2 | 235 | 0 | 39 |
4P LOSS WILD-TYPE | 103 | 515 | 672 | 327 | 400 | 242 | 458 | 493 | 0 | 313 | 2 | 120 |
P value = 5.22e-66 (Chi-square test), Q value = 8.1e-63
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
4P LOSS MUTATED | 81 | 4 | 18 | 77 | 35 | 2 | 7 | 19 | 2 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 133 | 3 | 1 | 37 | 1 | 237 | 26 | 0 | 2 |
4P LOSS WILD-TYPE | 275 | 50 | 332 | 242 | 458 | 8 | 68 | 186 | 5 | 3 | 14 | 2 | 3 | 1 | 12 | 0 | 1 | 0 | 2 | 182 | 15 | 6 | 106 | 12 | 315 | 53 | 1 | 18 |
P value = 1.94e-05 (Chi-square test), Q value = 0.025
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 1067 | 353 | 282 | 11 |
4P LOSS MUTATED | 199 | 84 | 84 | 6 |
4P LOSS WILD-TYPE | 868 | 269 | 198 | 5 |
P value = 9.69e-14 (Chi-square test), Q value = 1.4e-10
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
4P LOSS MUTATED | 125 | 92 | 290 | 117 |
4P LOSS WILD-TYPE | 587 | 406 | 591 | 306 |
P value = 3.67e-10 (Fisher's exact test), Q value = 5.2e-07
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
4P LOSS MUTATED | 103 | 814 |
4P LOSS WILD-TYPE | 723 | 2923 |
Cluster Labels | 4Q LOSS MUTATED | 4Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 859 | 3704 |
P value = 2.93e-108 (Chi-square test), Q value = 4.6e-105
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
4Q LOSS MUTATED | 18 | 28 | 139 | 70 | 45 | 50 | 29 | 154 | 2 | 277 | 1 | 42 |
4Q LOSS WILD-TYPE | 107 | 516 | 707 | 342 | 402 | 269 | 464 | 508 | 0 | 271 | 1 | 117 |
P value = 1.63e-06 (Fisher's exact test), Q value = 0.0022
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
4Q LOSS MUTATED | 603 | 256 |
4Q LOSS WILD-TYPE | 2278 | 1426 |
P value = 6.11e-88 (Chi-square test), Q value = 9.6e-85
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
4Q LOSS MUTATED | 67 | 3 | 19 | 50 | 29 | 2 | 8 | 22 | 1 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 114 | 4 | 1 | 40 | 1 | 280 | 22 | 0 | 1 |
4Q LOSS WILD-TYPE | 289 | 51 | 331 | 269 | 464 | 8 | 67 | 183 | 6 | 3 | 13 | 2 | 3 | 2 | 12 | 0 | 1 | 0 | 1 | 201 | 14 | 6 | 103 | 12 | 272 | 57 | 1 | 19 |
P value = 5.52e-05 (Chi-square test), Q value = 0.071
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
4Q LOSS MUTATED | 47 | 126 | 123 | 44 |
4Q LOSS WILD-TYPE | 419 | 506 | 571 | 165 |
P value = 6.53e-24 (Chi-square test), Q value = 9.7e-21
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
4Q LOSS MUTATED | 120 | 79 | 320 | 93 |
4Q LOSS WILD-TYPE | 592 | 419 | 561 | 330 |
P value = 3.28e-13 (Fisher's exact test), Q value = 4.7e-10
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
4Q LOSS MUTATED | 85 | 774 |
4Q LOSS WILD-TYPE | 741 | 2963 |
Cluster Labels | 5P LOSS MUTATED | 5P LOSS WILD-TYPE |
---|---|---|
Number of samples | 271 | 4292 |
P value = 6.07e-16 (Chi-square test), Q value = 8.8e-13
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
5P LOSS MUTATED | 12 | 24 | 59 | 27 | 21 | 9 | 2 | 34 | 1 | 71 | 0 | 11 |
5P LOSS WILD-TYPE | 113 | 520 | 787 | 385 | 426 | 310 | 491 | 628 | 1 | 477 | 2 | 148 |
P value = 9.78e-19 (Chi-square test), Q value = 1.4e-15
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
5P LOSS MUTATED | 26 | 1 | 8 | 9 | 2 | 2 | 4 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 21 | 0 | 0 | 11 | 0 | 72 | 13 | 0 | 0 |
5P LOSS WILD-TYPE | 330 | 53 | 342 | 310 | 491 | 8 | 71 | 202 | 7 | 3 | 14 | 2 | 3 | 2 | 11 | 0 | 1 | 1 | 2 | 294 | 18 | 7 | 132 | 13 | 480 | 66 | 1 | 20 |
P value = 1.69e-06 (Chi-square test), Q value = 0.0023
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
5P LOSS MUTATED | 22 | 25 | 82 | 21 |
5P LOSS WILD-TYPE | 690 | 473 | 799 | 402 |
Cluster Labels | 5Q LOSS MUTATED | 5Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 638 | 3925 |
P value = 5.52e-60 (Chi-square test), Q value = 8.6e-57
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
5Q LOSS MUTATED | 30 | 24 | 110 | 39 | 35 | 59 | 2 | 158 | 1 | 157 | 1 | 22 |
5Q LOSS WILD-TYPE | 95 | 520 | 736 | 373 | 412 | 260 | 491 | 504 | 1 | 391 | 1 | 137 |
P value = 2.65e-59 (Chi-square test), Q value = 4.1e-56
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
5Q LOSS MUTATED | 38 | 1 | 12 | 59 | 2 | 2 | 13 | 19 | 1 | 0 | 3 | 0 | 2 | 1 | 3 | 1 | 0 | 1 | 0 | 112 | 1 | 0 | 20 | 1 | 159 | 22 | 0 | 0 |
5Q LOSS WILD-TYPE | 318 | 53 | 338 | 260 | 491 | 8 | 62 | 186 | 6 | 3 | 12 | 2 | 1 | 1 | 10 | 0 | 1 | 0 | 2 | 203 | 17 | 7 | 123 | 12 | 393 | 57 | 1 | 20 |
P value = 5.38e-05 (Chi-square test), Q value = 0.07
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
5Q LOSS MUTATED | 46 | 110 | 77 | 40 |
5Q LOSS WILD-TYPE | 420 | 522 | 617 | 169 |
P value = 1.53e-05 (Chi-square test), Q value = 0.02
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
5Q LOSS MUTATED | 97 | 70 | 193 | 64 |
5Q LOSS WILD-TYPE | 615 | 428 | 688 | 359 |
Cluster Labels | 6P LOSS MUTATED | 6P LOSS WILD-TYPE |
---|---|---|
Number of samples | 450 | 4113 |
P value = 3.98e-28 (Chi-square test), Q value = 5.9e-25
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
6P LOSS MUTATED | 12 | 60 | 90 | 13 | 8 | 21 | 61 | 59 | 1 | 118 | 0 | 6 |
6P LOSS WILD-TYPE | 113 | 484 | 756 | 399 | 439 | 298 | 432 | 603 | 1 | 430 | 2 | 153 |
P value = 4.31e-26 (Chi-square test), Q value = 6.4e-23
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
6P LOSS MUTATED | 12 | 1 | 3 | 21 | 61 | 2 | 9 | 10 | 2 | 0 | 1 | 0 | 0 | 0 | 3 | 1 | 0 | 0 | 0 | 30 | 0 | 1 | 4 | 2 | 119 | 5 | 0 | 4 |
6P LOSS WILD-TYPE | 344 | 53 | 347 | 298 | 432 | 8 | 66 | 195 | 5 | 3 | 14 | 2 | 3 | 2 | 10 | 0 | 1 | 1 | 2 | 285 | 18 | 6 | 139 | 11 | 433 | 74 | 1 | 16 |
Cluster Labels | 6Q LOSS MUTATED | 6Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 711 | 3852 |
P value = 6.15e-07 (t-test), Q value = 0.00083
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 4507 | 61.9 (12.6) |
6Q LOSS MUTATED | 698 | 59.7 (12.4) |
6Q LOSS WILD-TYPE | 3809 | 62.2 (12.6) |
P value = 1.12e-54 (Chi-square test), Q value = 1.7e-51
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
6Q LOSS MUTATED | 24 | 90 | 151 | 21 | 9 | 22 | 84 | 108 | 2 | 187 | 0 | 11 |
6Q LOSS WILD-TYPE | 101 | 454 | 695 | 391 | 438 | 297 | 409 | 554 | 0 | 361 | 2 | 148 |
P value = 7.11e-54 (Chi-square test), Q value = 1.1e-50
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
6Q LOSS MUTATED | 18 | 3 | 4 | 22 | 84 | 4 | 19 | 39 | 2 | 2 | 3 | 0 | 0 | 0 | 5 | 1 | 0 | 0 | 0 | 32 | 0 | 1 | 8 | 3 | 189 | 5 | 0 | 6 |
6Q LOSS WILD-TYPE | 338 | 51 | 346 | 297 | 409 | 6 | 56 | 166 | 5 | 1 | 12 | 2 | 3 | 2 | 8 | 0 | 1 | 1 | 2 | 283 | 18 | 6 | 135 | 10 | 363 | 74 | 1 | 14 |
P value = 2.29e-06 (Chi-square test), Q value = 0.0031
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
6Q LOSS MUTATED | 104 | 60 | 195 | 65 |
6Q LOSS WILD-TYPE | 608 | 438 | 686 | 358 |
Cluster Labels | 7P LOSS MUTATED | 7P LOSS WILD-TYPE |
---|---|---|
Number of samples | 200 | 4363 |
P value = 3.37e-48 (Chi-square test), Q value = 5.2e-45
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
7P LOSS MUTATED | 0 | 4 | 44 | 0 | 28 | 5 | 1 | 29 | 0 | 86 | 1 | 2 |
7P LOSS WILD-TYPE | 125 | 540 | 802 | 412 | 419 | 314 | 492 | 633 | 2 | 462 | 1 | 157 |
P value = 1e-13 (Fisher's exact test), Q value = 1.4e-10
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
7P LOSS MUTATED | 173 | 27 |
7P LOSS WILD-TYPE | 2708 | 1655 |
P value = 1.84e-37 (Chi-square test), Q value = 2.8e-34
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
7P LOSS MUTATED | 0 | 0 | 11 | 5 | 1 | 0 | 1 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 19 | 1 | 0 | 1 | 1 | 87 | 16 | 0 | 0 |
7P LOSS WILD-TYPE | 356 | 54 | 339 | 314 | 492 | 10 | 74 | 198 | 7 | 3 | 15 | 2 | 3 | 2 | 11 | 1 | 1 | 1 | 2 | 296 | 17 | 7 | 142 | 12 | 465 | 63 | 1 | 20 |
P value = 9e-05 (Chi-square test), Q value = 0.12
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
7P LOSS MUTATED | 7 | 23 | 2 | 4 |
7P LOSS WILD-TYPE | 459 | 609 | 692 | 205 |
P value = 1.66e-14 (Chi-square test), Q value = 2.4e-11
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
7P LOSS MUTATED | 20 | 7 | 85 | 11 |
7P LOSS WILD-TYPE | 692 | 491 | 796 | 412 |
Cluster Labels | 7Q LOSS MUTATED | 7Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 162 | 4401 |
P value = 4.47e-20 (Chi-square test), Q value = 6.5e-17
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
7Q LOSS MUTATED | 2 | 3 | 61 | 1 | 23 | 8 | 1 | 21 | 0 | 39 | 1 | 2 |
7Q LOSS WILD-TYPE | 123 | 541 | 785 | 411 | 424 | 311 | 492 | 641 | 2 | 509 | 1 | 157 |
P value = 3.65e-11 (Fisher's exact test), Q value = 5.2e-08
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
7Q LOSS MUTATED | 140 | 22 |
7Q LOSS WILD-TYPE | 2741 | 1660 |
P value = 1.83e-23 (Chi-square test), Q value = 2.7e-20
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
7Q LOSS MUTATED | 1 | 0 | 6 | 8 | 1 | 0 | 0 | 8 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 9 | 1 | 2 | 1 | 1 | 40 | 16 | 0 | 0 |
7Q LOSS WILD-TYPE | 355 | 54 | 344 | 311 | 492 | 10 | 75 | 197 | 7 | 3 | 15 | 1 | 3 | 2 | 12 | 1 | 1 | 1 | 2 | 306 | 17 | 5 | 142 | 12 | 512 | 63 | 1 | 20 |
P value = 3.89e-05 (Chi-square test), Q value = 0.051
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
7Q LOSS MUTATED | 4 | 22 | 3 | 2 |
7Q LOSS WILD-TYPE | 462 | 610 | 691 | 207 |
Cluster Labels | 8P LOSS MUTATED | 8P LOSS WILD-TYPE |
---|---|---|
Number of samples | 1074 | 3489 |
P value = 7.91e-53 (Chi-square test), Q value = 1.2e-49
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
8P LOSS MUTATED | 40 | 39 | 249 | 93 | 43 | 57 | 94 | 175 | 2 | 225 | 0 | 55 |
8P LOSS WILD-TYPE | 85 | 505 | 597 | 319 | 404 | 262 | 399 | 487 | 0 | 323 | 2 | 104 |
P value = 8.98e-35 (Chi-square test), Q value = 1.4e-31
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
8P LOSS MUTATED | 86 | 6 | 11 | 57 | 94 | 2 | 16 | 56 | 2 | 0 | 5 | 1 | 3 | 0 | 2 | 1 | 0 | 0 | 0 | 87 | 2 | 0 | 51 | 4 | 227 | 30 | 0 | 3 |
8P LOSS WILD-TYPE | 270 | 48 | 339 | 262 | 399 | 8 | 59 | 149 | 5 | 3 | 10 | 1 | 0 | 2 | 11 | 0 | 1 | 1 | 2 | 228 | 16 | 7 | 92 | 9 | 325 | 49 | 1 | 17 |
P value = 1.33e-07 (Chi-square test), Q value = 0.00018
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
8P LOSS MUTATED | 162 | 116 | 303 | 106 |
8P LOSS WILD-TYPE | 550 | 382 | 578 | 317 |
P value = 6.06e-10 (Fisher's exact test), Q value = 8.5e-07
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
8P LOSS MUTATED | 128 | 946 |
8P LOSS WILD-TYPE | 698 | 2791 |
Cluster Labels | 8Q LOSS MUTATED | 8Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 219 | 4344 |
P value = 1.78e-12 (Chi-square test), Q value = 2.5e-09
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
8Q LOSS MUTATED | 5 | 28 | 39 | 9 | 8 | 6 | 40 | 19 | 0 | 58 | 0 | 6 |
8Q LOSS WILD-TYPE | 120 | 516 | 807 | 403 | 439 | 313 | 453 | 643 | 2 | 490 | 2 | 153 |
P value = 8.37e-10 (Chi-square test), Q value = 1.2e-06
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
8Q LOSS MUTATED | 8 | 1 | 1 | 6 | 40 | 0 | 1 | 8 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 9 | 0 | 0 | 6 | 0 | 58 | 7 | 0 | 1 |
8Q LOSS WILD-TYPE | 348 | 53 | 349 | 313 | 453 | 10 | 74 | 197 | 7 | 3 | 15 | 2 | 2 | 2 | 13 | 1 | 1 | 1 | 2 | 306 | 18 | 7 | 137 | 13 | 494 | 72 | 1 | 19 |
P value = 0.000142 (Chi-square test), Q value = 0.18
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
8Q LOSS MUTATED | 32 | 19 | 71 | 13 |
8Q LOSS WILD-TYPE | 680 | 479 | 810 | 410 |
Cluster Labels | 9P LOSS MUTATED | 9P LOSS WILD-TYPE |
---|---|---|
Number of samples | 1105 | 3458 |
P value = 2.53e-13 (logrank test), Q value = 3.6e-10
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
9P LOSS MUTATED | 1051 | 438 | 0.0 - 162.0 (14.3) |
9P LOSS WILD-TYPE | 3245 | 963 | 0.0 - 224.0 (14.9) |
P value = 3.23e-49 (Chi-square test), Q value = 5e-46
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
9P LOSS MUTATED | 38 | 180 | 178 | 27 | 61 | 86 | 88 | 234 | 0 | 199 | 2 | 12 |
9P LOSS WILD-TYPE | 87 | 364 | 668 | 385 | 386 | 233 | 405 | 428 | 2 | 349 | 0 | 147 |
P value = 2.07e-49 (Chi-square test), Q value = 3.2e-46
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
9P LOSS MUTATED | 25 | 2 | 23 | 86 | 88 | 5 | 24 | 57 | 2 | 1 | 3 | 0 | 1 | 1 | 4 | 1 | 0 | 1 | 2 | 130 | 4 | 2 | 11 | 1 | 201 | 34 | 0 | 9 |
9P LOSS WILD-TYPE | 331 | 52 | 327 | 233 | 405 | 5 | 51 | 148 | 5 | 2 | 12 | 2 | 2 | 1 | 9 | 0 | 1 | 0 | 0 | 185 | 14 | 5 | 132 | 12 | 351 | 45 | 1 | 11 |
P value = 9.7e-09 (Chi-square test), Q value = 1.4e-05
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
9P LOSS MUTATED | 101 | 186 | 105 | 42 |
9P LOSS WILD-TYPE | 365 | 446 | 589 | 167 |
Cluster Labels | 9Q LOSS MUTATED | 9Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 900 | 3663 |
P value = 0.00016 (logrank test), Q value = 0.2
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
9Q LOSS MUTATED | 853 | 343 | 0.1 - 162.0 (17.9) |
9Q LOSS WILD-TYPE | 3443 | 1058 | 0.0 - 224.0 (14.2) |
P value = 8.8e-58 (Chi-square test), Q value = 1.4e-54
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
9Q LOSS MUTATED | 36 | 92 | 134 | 24 | 80 | 29 | 92 | 171 | 0 | 228 | 2 | 10 |
9Q LOSS WILD-TYPE | 89 | 452 | 712 | 388 | 367 | 290 | 401 | 491 | 2 | 320 | 0 | 149 |
P value = 1.1e-56 (Chi-square test), Q value = 1.7e-53
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
9Q LOSS MUTATED | 23 | 1 | 36 | 29 | 92 | 5 | 17 | 52 | 1 | 0 | 3 | 0 | 1 | 0 | 4 | 1 | 0 | 1 | 2 | 83 | 5 | 1 | 9 | 1 | 230 | 39 | 0 | 5 |
9Q LOSS WILD-TYPE | 333 | 53 | 314 | 290 | 401 | 5 | 58 | 153 | 6 | 3 | 12 | 2 | 2 | 2 | 9 | 0 | 1 | 0 | 0 | 232 | 13 | 6 | 134 | 12 | 322 | 40 | 1 | 15 |
P value = 7.3e-09 (Chi-square test), Q value = 1e-05
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
9Q LOSS MUTATED | 132 | 82 | 254 | 79 |
9Q LOSS WILD-TYPE | 580 | 416 | 627 | 344 |
Cluster Labels | 10P LOSS MUTATED | 10P LOSS WILD-TYPE |
---|---|---|
Number of samples | 808 | 3755 |
P value = 0 (logrank test), Q value = 0
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
10P LOSS MUTATED | 787 | 439 | 0.0 - 131.2 (10.6) |
10P LOSS WILD-TYPE | 3509 | 962 | 0.0 - 224.0 (16.6) |
P value = 0 (Chi-square test), Q value = 0
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
10P LOSS MUTATED | 16 | 432 | 65 | 23 | 18 | 48 | 32 | 97 | 0 | 59 | 0 | 17 |
10P LOSS WILD-TYPE | 109 | 112 | 781 | 389 | 429 | 271 | 461 | 565 | 2 | 489 | 2 | 142 |
P value = 2.5e-22 (Fisher's exact test), Q value = 3.7e-19
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
10P LOSS MUTATED | 387 | 421 |
10P LOSS WILD-TYPE | 2494 | 1261 |
P value = 9.96e-37 (Chi-square test), Q value = 1.5e-33
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
10P LOSS MUTATED | 20 | 3 | 7 | 48 | 32 | 2 | 2 | 19 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 68 | 1 | 1 | 13 | 4 | 59 | 10 | 1 | 16 |
10P LOSS WILD-TYPE | 336 | 51 | 343 | 271 | 461 | 8 | 73 | 186 | 5 | 2 | 15 | 2 | 2 | 2 | 13 | 0 | 1 | 1 | 2 | 247 | 17 | 6 | 130 | 9 | 493 | 69 | 0 | 4 |
P value = 9.03e-59 (Fisher's exact test), Q value = 1.4e-55
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
10P LOSS MUTATED | 320 | 488 |
10P LOSS WILD-TYPE | 506 | 3249 |
Cluster Labels | 10Q LOSS MUTATED | 10Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 895 | 3668 |
P value = 0 (logrank test), Q value = 0
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
10Q LOSS MUTATED | 865 | 463 | 0.0 - 131.2 (11.2) |
10Q LOSS WILD-TYPE | 3431 | 938 | 0.0 - 224.0 (16.7) |
P value = 0 (Chi-square test), Q value = 0
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
10Q LOSS MUTATED | 24 | 448 | 102 | 24 | 17 | 29 | 48 | 99 | 0 | 81 | 0 | 22 |
10Q LOSS WILD-TYPE | 101 | 96 | 744 | 388 | 430 | 290 | 445 | 563 | 2 | 467 | 2 | 137 |
P value = 2.6e-17 (Fisher's exact test), Q value = 3.8e-14
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
10Q LOSS MUTATED | 454 | 441 |
10Q LOSS WILD-TYPE | 2427 | 1241 |
P value = 5.71e-41 (Chi-square test), Q value = 8.7e-38
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
10Q LOSS MUTATED | 21 | 3 | 9 | 29 | 48 | 1 | 5 | 17 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 2 | 68 | 1 | 1 | 18 | 4 | 81 | 7 | 1 | 18 |
10Q LOSS WILD-TYPE | 335 | 51 | 341 | 290 | 445 | 9 | 70 | 188 | 6 | 2 | 15 | 2 | 1 | 2 | 13 | 0 | 1 | 1 | 0 | 247 | 17 | 6 | 125 | 9 | 471 | 72 | 0 | 2 |
P value = 2.56e-56 (Fisher's exact test), Q value = 4e-53
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
10Q LOSS MUTATED | 337 | 558 |
10Q LOSS WILD-TYPE | 489 | 3179 |
Cluster Labels | 11P LOSS MUTATED | 11P LOSS WILD-TYPE |
---|---|---|
Number of samples | 587 | 3976 |
P value = 7.63e-41 (Chi-square test), Q value = 1.2e-37
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
11P LOSS MUTATED | 39 | 66 | 133 | 21 | 45 | 43 | 5 | 73 | 0 | 143 | 0 | 19 |
11P LOSS WILD-TYPE | 86 | 478 | 713 | 391 | 402 | 276 | 488 | 589 | 2 | 405 | 2 | 140 |
P value = 1.95e-05 (Fisher's exact test), Q value = 0.026
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
11P LOSS MUTATED | 417 | 170 |
11P LOSS WILD-TYPE | 2464 | 1512 |
P value = 1.17e-36 (Chi-square test), Q value = 1.8e-33
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
11P LOSS MUTATED | 21 | 0 | 21 | 43 | 5 | 0 | 4 | 16 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 48 | 4 | 0 | 14 | 4 | 143 | 20 | 0 | 3 |
11P LOSS WILD-TYPE | 335 | 54 | 329 | 276 | 488 | 10 | 71 | 189 | 6 | 3 | 14 | 1 | 3 | 2 | 12 | 1 | 1 | 0 | 2 | 267 | 14 | 7 | 129 | 9 | 409 | 59 | 1 | 17 |
P value = 4.77e-05 (Chi-square test), Q value = 0.062
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 1067 | 353 | 282 | 11 |
11P LOSS MUTATED | 68 | 47 | 29 | 3 |
11P LOSS WILD-TYPE | 999 | 306 | 253 | 8 |
P value = 2.7e-12 (Chi-square test), Q value = 3.8e-09
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
11P LOSS MUTATED | 48 | 40 | 158 | 47 |
11P LOSS WILD-TYPE | 664 | 458 | 723 | 376 |
P value = 2.25e-06 (Chi-square test), Q value = 0.003
nPatients | 1 | 2 | 3 | 4 | 5 | CURRENT REFORMED SMOKER FOR < OR = 15 YEARS | CURRENT REFORMED SMOKER FOR > 15 YEARS | CURRENT SMOKER | LIFELONG NON-SMOKER |
---|---|---|---|---|---|---|---|---|---|
ALL | 28 | 23 | 37 | 29 | 2 | 355 | 217 | 250 | 128 |
11P LOSS MUTATED | 10 | 6 | 10 | 9 | 1 | 49 | 18 | 38 | 8 |
11P LOSS WILD-TYPE | 18 | 17 | 27 | 20 | 1 | 306 | 199 | 212 | 120 |
Cluster Labels | 11Q LOSS MUTATED | 11Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 609 | 3954 |
P value = 2.05e-44 (Chi-square test), Q value = 3.1e-41
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
11Q LOSS MUTATED | 29 | 56 | 211 | 27 | 37 | 61 | 8 | 54 | 0 | 101 | 0 | 23 |
11Q LOSS WILD-TYPE | 96 | 488 | 635 | 385 | 410 | 258 | 485 | 608 | 2 | 447 | 2 | 136 |
P value = 5.76e-05 (Fisher's exact test), Q value = 0.074
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
11Q LOSS MUTATED | 429 | 180 |
11Q LOSS WILD-TYPE | 2452 | 1502 |
P value = 4.7e-22 (Chi-square test), Q value = 6.9e-19
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
11Q LOSS MUTATED | 25 | 2 | 16 | 61 | 8 | 1 | 5 | 10 | 0 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 33 | 5 | 0 | 17 | 5 | 101 | 16 | 0 | 3 |
11Q LOSS WILD-TYPE | 331 | 52 | 334 | 258 | 485 | 9 | 70 | 195 | 7 | 3 | 13 | 1 | 3 | 2 | 11 | 1 | 1 | 1 | 2 | 282 | 13 | 7 | 126 | 8 | 451 | 63 | 1 | 17 |
P value = 1.04e-05 (Chi-square test), Q value = 0.014
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
11Q LOSS MUTATED | 43 | 46 | 119 | 51 |
11Q LOSS WILD-TYPE | 669 | 452 | 762 | 372 |
Cluster Labels | 12P LOSS MUTATED | 12P LOSS WILD-TYPE |
---|---|---|
Number of samples | 256 | 4307 |
P value = 2.2e-07 (Chi-square test), Q value = 3e-04
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
12P LOSS MUTATED | 6 | 47 | 62 | 21 | 18 | 11 | 2 | 33 | 0 | 44 | 0 | 12 |
12P LOSS WILD-TYPE | 119 | 497 | 784 | 391 | 429 | 308 | 491 | 629 | 2 | 504 | 2 | 147 |
P value = 1.32e-10 (Chi-square test), Q value = 1.9e-07
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
12P LOSS MUTATED | 21 | 0 | 6 | 11 | 2 | 0 | 6 | 18 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 12 | 0 | 44 | 11 | 0 | 2 |
12P LOSS WILD-TYPE | 335 | 54 | 344 | 308 | 491 | 10 | 69 | 187 | 7 | 3 | 13 | 2 | 3 | 2 | 11 | 1 | 1 | 1 | 1 | 311 | 17 | 7 | 131 | 13 | 508 | 68 | 1 | 18 |
Cluster Labels | 12Q LOSS MUTATED | 12Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 237 | 4326 |
P value = 3.31e-16 (Chi-square test), Q value = 4.8e-13
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
12Q LOSS MUTATED | 8 | 45 | 48 | 20 | 12 | 7 | 2 | 21 | 0 | 64 | 0 | 10 |
12Q LOSS WILD-TYPE | 117 | 499 | 798 | 392 | 435 | 312 | 491 | 641 | 2 | 484 | 2 | 149 |
P value = 7.04e-16 (Chi-square test), Q value = 1e-12
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
12Q LOSS MUTATED | 20 | 0 | 4 | 7 | 2 | 0 | 6 | 10 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 10 | 0 | 64 | 7 | 0 | 1 |
12Q LOSS WILD-TYPE | 336 | 54 | 346 | 312 | 491 | 10 | 69 | 195 | 7 | 3 | 14 | 2 | 3 | 2 | 12 | 1 | 1 | 1 | 1 | 313 | 17 | 7 | 133 | 13 | 488 | 72 | 1 | 19 |
Cluster Labels | 13Q LOSS MUTATED | 13Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 1007 | 3556 |
P value = 7.7e-88 (Chi-square test), Q value = 1.2e-84
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
13Q LOSS MUTATED | 18 | 148 | 248 | 7 | 52 | 61 | 33 | 194 | 1 | 238 | 2 | 5 |
13Q LOSS WILD-TYPE | 107 | 396 | 598 | 405 | 395 | 258 | 460 | 468 | 1 | 310 | 0 | 154 |
P value = 1.22e-06 (Fisher's exact test), Q value = 0.0016
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
13Q LOSS MUTATED | 701 | 306 |
13Q LOSS WILD-TYPE | 2180 | 1376 |
P value = 1.53e-83 (Chi-square test), Q value = 2.4e-80
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
13Q LOSS MUTATED | 6 | 1 | 30 | 61 | 33 | 6 | 15 | 47 | 0 | 0 | 5 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 116 | 3 | 1 | 4 | 1 | 241 | 19 | 0 | 6 |
13Q LOSS WILD-TYPE | 350 | 53 | 320 | 258 | 460 | 4 | 60 | 158 | 7 | 3 | 10 | 1 | 2 | 2 | 12 | 1 | 1 | 1 | 1 | 199 | 15 | 6 | 139 | 12 | 311 | 60 | 1 | 14 |
P value = 9.98e-12 (Chi-square test), Q value = 1.4e-08
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
13Q LOSS MUTATED | 66 | 136 | 52 | 37 |
13Q LOSS WILD-TYPE | 400 | 496 | 642 | 172 |
P value = 1.38e-08 (Chi-square test), Q value = 1.9e-05
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
13Q LOSS MUTATED | 112 | 85 | 243 | 90 |
13Q LOSS WILD-TYPE | 600 | 413 | 638 | 333 |
Cluster Labels | 14Q LOSS MUTATED | 14Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 866 | 3697 |
P value = 1.77e-38 (Chi-square test), Q value = 2.7e-35
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
14Q LOSS MUTATED | 19 | 123 | 120 | 94 | 39 | 17 | 159 | 89 | 0 | 155 | 0 | 49 |
14Q LOSS WILD-TYPE | 106 | 421 | 726 | 318 | 408 | 302 | 334 | 573 | 2 | 393 | 2 | 110 |
P value = 1.06e-38 (Chi-square test), Q value = 1.6e-35
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
14Q LOSS MUTATED | 91 | 3 | 13 | 17 | 159 | 2 | 7 | 14 | 0 | 0 | 3 | 1 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 58 | 3 | 0 | 49 | 0 | 155 | 23 | 0 | 2 |
14Q LOSS WILD-TYPE | 265 | 51 | 337 | 302 | 334 | 8 | 68 | 191 | 7 | 3 | 12 | 1 | 3 | 1 | 11 | 1 | 1 | 0 | 2 | 257 | 15 | 7 | 94 | 13 | 397 | 56 | 1 | 18 |
P value = 2.02e-07 (Chi-square test), Q value = 0.00028
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
14Q LOSS MUTATED | 101 | 108 | 177 | 18 |
14Q LOSS WILD-TYPE | 365 | 524 | 517 | 191 |
P value = 0.000151 (Chi-square test), Q value = 0.19
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 1067 | 353 | 282 | 11 |
14Q LOSS MUTATED | 214 | 82 | 30 | 0 |
14Q LOSS WILD-TYPE | 853 | 271 | 252 | 11 |
P value = 5.75e-05 (Chi-square test), Q value = 0.074
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 1424 | 168 | 9 | 3 | 165 |
14Q LOSS MUTATED | 317 | 54 | 3 | 0 | 17 |
14Q LOSS WILD-TYPE | 1107 | 114 | 6 | 3 | 148 |
Cluster Labels | 15Q LOSS MUTATED | 15Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 803 | 3760 |
P value = 3.19e-60 (Chi-square test), Q value = 5e-57
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
15Q LOSS MUTATED | 15 | 73 | 151 | 99 | 64 | 23 | 12 | 103 | 1 | 202 | 2 | 55 |
15Q LOSS WILD-TYPE | 110 | 471 | 695 | 313 | 383 | 296 | 481 | 559 | 1 | 346 | 0 | 104 |
P value = 1.96e-12 (Fisher's exact test), Q value = 2.8e-09
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
15Q LOSS MUTATED | 593 | 210 |
15Q LOSS WILD-TYPE | 2288 | 1472 |
P value = 3.38e-63 (Chi-square test), Q value = 5.3e-60
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
15Q LOSS MUTATED | 95 | 4 | 27 | 23 | 12 | 1 | 10 | 47 | 0 | 0 | 3 | 0 | 2 | 0 | 5 | 0 | 0 | 1 | 1 | 33 | 6 | 0 | 50 | 4 | 205 | 31 | 0 | 5 |
15Q LOSS WILD-TYPE | 261 | 50 | 323 | 296 | 481 | 9 | 65 | 158 | 7 | 3 | 12 | 2 | 1 | 2 | 8 | 1 | 1 | 0 | 1 | 282 | 12 | 7 | 93 | 9 | 347 | 48 | 1 | 15 |
P value = 1.85e-06 (Chi-square test), Q value = 0.0025
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
15Q LOSS MUTATED | 41 | 83 | 138 | 29 |
15Q LOSS WILD-TYPE | 425 | 549 | 556 | 180 |
P value = 3.04e-14 (Chi-square test), Q value = 4.4e-11
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
15Q LOSS MUTATED | 74 | 97 | 234 | 81 |
15Q LOSS WILD-TYPE | 638 | 401 | 647 | 342 |
Cluster Labels | 16P LOSS MUTATED | 16P LOSS WILD-TYPE |
---|---|---|
Number of samples | 499 | 4064 |
P value = 3.63e-173 (Chi-square test), Q value = 5.8e-170
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
16P LOSS MUTATED | 14 | 30 | 47 | 7 | 57 | 12 | 2 | 72 | 2 | 248 | 1 | 7 |
16P LOSS WILD-TYPE | 111 | 514 | 799 | 405 | 390 | 307 | 491 | 590 | 0 | 300 | 1 | 152 |
P value = 8.69e-20 (Fisher's exact test), Q value = 1.3e-16
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
16P LOSS MUTATED | 404 | 95 |
16P LOSS WILD-TYPE | 2477 | 1587 |
P value = 1.47e-134 (Chi-square test), Q value = 2.3e-131
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
16P LOSS MUTATED | 5 | 2 | 24 | 12 | 2 | 1 | 5 | 14 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 46 | 5 | 1 | 5 | 1 | 251 | 28 | 0 | 1 |
16P LOSS WILD-TYPE | 351 | 52 | 326 | 307 | 491 | 9 | 70 | 191 | 7 | 3 | 14 | 1 | 2 | 2 | 12 | 1 | 1 | 1 | 1 | 269 | 13 | 6 | 138 | 12 | 301 | 51 | 1 | 19 |
P value = 9.54e-28 (Chi-square test), Q value = 1.4e-24
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
16P LOSS MUTATED | 46 | 32 | 209 | 57 |
16P LOSS WILD-TYPE | 666 | 466 | 672 | 366 |
P value = 3.42e-06 (Fisher's exact test), Q value = 0.0046
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
16P LOSS MUTATED | 54 | 445 |
16P LOSS WILD-TYPE | 772 | 3292 |
Cluster Labels | 16Q LOSS MUTATED | 16Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 1000 | 3563 |
P value = 1.19e-229 (Chi-square test), Q value = 1.9e-226
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
16Q LOSS MUTATED | 15 | 45 | 351 | 5 | 94 | 24 | 5 | 104 | 1 | 344 | 2 | 10 |
16Q LOSS WILD-TYPE | 110 | 499 | 495 | 407 | 353 | 295 | 488 | 558 | 1 | 204 | 0 | 149 |
P value = 7.3e-72 (Fisher's exact test), Q value = 1.1e-68
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
16Q LOSS MUTATED | 860 | 140 |
16Q LOSS WILD-TYPE | 2021 | 1542 |
P value = 1.95e-195 (Chi-square test), Q value = 3.1e-192
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
16Q LOSS MUTATED | 3 | 2 | 45 | 24 | 5 | 3 | 9 | 24 | 0 | 0 | 3 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 59 | 6 | 1 | 8 | 1 | 347 | 43 | 0 | 4 |
16Q LOSS WILD-TYPE | 353 | 52 | 305 | 295 | 488 | 7 | 66 | 181 | 7 | 3 | 12 | 0 | 2 | 2 | 12 | 1 | 1 | 1 | 1 | 256 | 12 | 6 | 135 | 12 | 205 | 36 | 1 | 16 |
P value = 1.01e-06 (Chi-square test), Q value = 0.0014
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
16Q LOSS MUTATED | 29 | 71 | 26 | 11 |
16Q LOSS WILD-TYPE | 437 | 561 | 668 | 198 |
P value = 3.38e-42 (Chi-square test), Q value = 5.1e-39
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
16Q LOSS MUTATED | 69 | 44 | 295 | 69 |
16Q LOSS WILD-TYPE | 643 | 454 | 586 | 354 |
P value = 1.07e-05 (Chi-square test), Q value = 0.014
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 1171 | 69 | 59 | 77 |
16Q LOSS MUTATED | 141 | 23 | 9 | 11 |
16Q LOSS WILD-TYPE | 1030 | 46 | 50 | 66 |
P value = 9.99e-06 (Chi-square test), Q value = 0.013
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE TIS | STAGE X |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 72 | 62 | 7 | 43 | 287 | 186 | 42 | 124 | 25 | 41 | 59 | 1 | 16 |
16Q LOSS MUTATED | 32 | 30 | 1 | 7 | 131 | 67 | 4 | 48 | 10 | 16 | 12 | 0 | 7 |
16Q LOSS WILD-TYPE | 40 | 32 | 6 | 36 | 156 | 119 | 38 | 76 | 15 | 25 | 47 | 1 | 9 |
Cluster Labels | 17P LOSS MUTATED | 17P LOSS WILD-TYPE |
---|---|---|
Number of samples | 1418 | 3145 |
P value = 2.2e-195 (Chi-square test), Q value = 3.5e-192
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
17P LOSS MUTATED | 35 | 38 | 352 | 162 | 86 | 41 | 24 | 187 | 1 | 403 | 1 | 85 |
17P LOSS WILD-TYPE | 90 | 506 | 494 | 250 | 361 | 278 | 469 | 475 | 1 | 145 | 1 | 74 |
P value = 1.96e-32 (Fisher's exact test), Q value = 2.9e-29
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
17P LOSS MUTATED | 1071 | 347 |
17P LOSS WILD-TYPE | 1810 | 1335 |
P value = 5.37e-162 (Chi-square test), Q value = 8.5e-159
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
17P LOSS MUTATED | 155 | 7 | 33 | 41 | 24 | 2 | 15 | 54 | 3 | 1 | 2 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 104 | 8 | 2 | 78 | 6 | 405 | 45 | 0 | 0 |
17P LOSS WILD-TYPE | 201 | 47 | 317 | 278 | 469 | 8 | 60 | 151 | 4 | 2 | 13 | 1 | 2 | 2 | 12 | 1 | 1 | 0 | 2 | 211 | 10 | 5 | 65 | 7 | 147 | 34 | 1 | 20 |
P value = 2.22e-07 (Chi-square test), Q value = 3e-04
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
17P LOSS MUTATED | 75 | 164 | 212 | 43 |
17P LOSS WILD-TYPE | 391 | 468 | 482 | 166 |
P value = 2.74e-31 (Chi-square test), Q value = 4.1e-28
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
17P LOSS MUTATED | 154 | 162 | 440 | 133 |
17P LOSS WILD-TYPE | 558 | 336 | 441 | 290 |
P value = 3.23e-23 (Fisher's exact test), Q value = 4.8e-20
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
17P LOSS MUTATED | 142 | 1276 |
17P LOSS WILD-TYPE | 684 | 2461 |
Cluster Labels | 17Q LOSS MUTATED | 17Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 629 | 3934 |
P value = 9.79e-204 (Chi-square test), Q value = 1.6e-200
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
17Q LOSS MUTATED | 6 | 25 | 134 | 35 | 57 | 5 | 12 | 32 | 1 | 301 | 1 | 20 |
17Q LOSS WILD-TYPE | 119 | 519 | 712 | 377 | 390 | 314 | 481 | 630 | 1 | 247 | 1 | 139 |
P value = 8.72e-49 (Fisher's exact test), Q value = 1.3e-45
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
17Q LOSS MUTATED | 551 | 78 |
17Q LOSS WILD-TYPE | 2330 | 1604 |
P value = 1.38e-170 (Chi-square test), Q value = 2.2e-167
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
17Q LOSS MUTATED | 33 | 2 | 29 | 5 | 12 | 0 | 3 | 9 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 18 | 6 | 0 | 17 | 2 | 303 | 22 | 0 | 0 |
17Q LOSS WILD-TYPE | 323 | 52 | 321 | 314 | 481 | 10 | 72 | 196 | 7 | 3 | 15 | 2 | 2 | 2 | 12 | 1 | 1 | 1 | 2 | 297 | 12 | 7 | 126 | 11 | 249 | 57 | 1 | 20 |
P value = 2.14e-45 (Chi-square test), Q value = 3.3e-42
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
17Q LOSS MUTATED | 36 | 41 | 262 | 62 |
17Q LOSS WILD-TYPE | 676 | 457 | 619 | 361 |
P value = 2.1e-08 (Fisher's exact test), Q value = 2.9e-05
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
17Q LOSS MUTATED | 66 | 563 |
17Q LOSS WILD-TYPE | 760 | 3174 |
P value = 8.95e-05 (Chi-square test), Q value = 0.11
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 1171 | 69 | 59 | 77 |
17Q LOSS MUTATED | 102 | 17 | 6 | 12 |
17Q LOSS WILD-TYPE | 1069 | 52 | 53 | 65 |
Cluster Labels | 18P LOSS MUTATED | 18P LOSS WILD-TYPE |
---|---|---|
Number of samples | 931 | 3632 |
P value = 1.86e-147 (Chi-square test), Q value = 2.9e-144
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
18P LOSS MUTATED | 18 | 50 | 168 | 212 | 28 | 27 | 46 | 91 | 1 | 175 | 0 | 112 |
18P LOSS WILD-TYPE | 107 | 494 | 678 | 200 | 419 | 292 | 447 | 571 | 1 | 373 | 2 | 47 |
P value = 1.74e-130 (Chi-square test), Q value = 2.7e-127
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
18P LOSS MUTATED | 204 | 7 | 16 | 27 | 46 | 2 | 15 | 30 | 0 | 0 | 3 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 34 | 5 | 3 | 107 | 5 | 176 | 7 | 0 | 4 |
18P LOSS WILD-TYPE | 152 | 47 | 334 | 292 | 447 | 8 | 60 | 175 | 7 | 3 | 12 | 2 | 1 | 2 | 11 | 1 | 1 | 1 | 2 | 281 | 13 | 4 | 36 | 8 | 376 | 72 | 1 | 16 |
P value = 1.75e-26 (Chi-square test), Q value = 2.6e-23
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
18P LOSS MUTATED | 44 | 131 | 258 | 54 |
18P LOSS WILD-TYPE | 422 | 501 | 436 | 155 |
P value = 4.8e-09 (Chi-square test), Q value = 6.7e-06
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 1424 | 168 | 9 | 3 | 165 |
18P LOSS MUTATED | 336 | 73 | 7 | 0 | 42 |
18P LOSS WILD-TYPE | 1088 | 95 | 2 | 3 | 123 |
P value = 5e-12 (Chi-square test), Q value = 7.1e-09
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
18P LOSS MUTATED | 110 | 139 | 274 | 120 |
18P LOSS WILD-TYPE | 602 | 359 | 607 | 303 |
P value = 4.81e-12 (Fisher's exact test), Q value = 6.8e-09
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
18P LOSS MUTATED | 99 | 832 |
18P LOSS WILD-TYPE | 727 | 2905 |
Cluster Labels | 18Q LOSS MUTATED | 18Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 1126 | 3437 |
P value = 3.22e-05 (t-test), Q value = 0.042
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 4507 | 61.9 (12.6) |
18Q LOSS MUTATED | 1109 | 63.2 (12.2) |
18Q LOSS WILD-TYPE | 3398 | 61.4 (12.7) |
P value = 6.45e-148 (Chi-square test), Q value = 1e-144
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
18Q LOSS MUTATED | 31 | 43 | 168 | 226 | 41 | 85 | 48 | 139 | 1 | 217 | 0 | 123 |
18Q LOSS WILD-TYPE | 94 | 501 | 678 | 186 | 406 | 234 | 445 | 523 | 1 | 331 | 2 | 36 |
P value = 1.9e-112 (Chi-square test), Q value = 3e-109
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
18Q LOSS MUTATED | 215 | 10 | 20 | 85 | 48 | 3 | 23 | 42 | 0 | 0 | 5 | 1 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 57 | 6 | 3 | 113 | 9 | 218 | 15 | 0 | 5 |
18Q LOSS WILD-TYPE | 141 | 44 | 330 | 234 | 445 | 7 | 52 | 163 | 7 | 3 | 10 | 1 | 1 | 1 | 12 | 0 | 1 | 1 | 2 | 258 | 12 | 4 | 30 | 4 | 334 | 64 | 1 | 15 |
P value = 3.09e-24 (Chi-square test), Q value = 4.6e-21
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
18Q LOSS MUTATED | 67 | 177 | 298 | 77 |
18Q LOSS WILD-TYPE | 399 | 455 | 396 | 132 |
P value = 8.37e-07 (Chi-square test), Q value = 0.0011
nPatients | N0 | N1 | N2 | N3 |
---|---|---|---|---|
ALL | 1067 | 353 | 282 | 11 |
18Q LOSS MUTATED | 311 | 148 | 121 | 4 |
18Q LOSS WILD-TYPE | 756 | 205 | 161 | 7 |
P value = 2.29e-05 (Chi-square test), Q value = 0.03
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 1424 | 168 | 9 | 3 | 165 |
18Q LOSS MUTATED | 408 | 73 | 7 | 0 | 54 |
18Q LOSS WILD-TYPE | 1016 | 95 | 2 | 3 | 111 |
P value = 5.26e-14 (Chi-square test), Q value = 7.5e-11
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
18Q LOSS MUTATED | 146 | 182 | 328 | 160 |
18Q LOSS WILD-TYPE | 566 | 316 | 553 | 263 |
P value = 2.46e-19 (Fisher's exact test), Q value = 3.6e-16
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
18Q LOSS MUTATED | 108 | 1018 |
18Q LOSS WILD-TYPE | 718 | 2719 |
Cluster Labels | 19P LOSS MUTATED | 19P LOSS WILD-TYPE |
---|---|---|
Number of samples | 446 | 4117 |
P value = 6.43e-67 (Chi-square test), Q value = 1e-63
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
19P LOSS MUTATED | 8 | 17 | 66 | 16 | 30 | 23 | 4 | 137 | 1 | 137 | 0 | 7 |
19P LOSS WILD-TYPE | 117 | 527 | 780 | 396 | 417 | 296 | 489 | 525 | 1 | 411 | 2 | 152 |
P value = 3.63e-51 (Chi-square test), Q value = 5.6e-48
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
19P LOSS MUTATED | 15 | 1 | 10 | 23 | 4 | 2 | 24 | 47 | 0 | 0 | 5 | 0 | 1 | 1 | 3 | 0 | 0 | 1 | 1 | 50 | 2 | 2 | 6 | 0 | 138 | 18 | 0 | 2 |
19P LOSS WILD-TYPE | 341 | 53 | 340 | 296 | 489 | 8 | 51 | 158 | 7 | 3 | 10 | 2 | 2 | 1 | 10 | 1 | 1 | 0 | 1 | 265 | 16 | 5 | 137 | 13 | 414 | 61 | 1 | 18 |
P value = 2.22e-07 (Chi-square test), Q value = 3e-04
nPatients | T0+T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 466 | 632 | 694 | 209 |
19P LOSS MUTATED | 37 | 90 | 36 | 22 |
19P LOSS WILD-TYPE | 429 | 542 | 658 | 187 |
P value = 3.85e-06 (Chi-square test), Q value = 0.0051
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
19P LOSS MUTATED | 71 | 54 | 154 | 41 |
19P LOSS WILD-TYPE | 641 | 444 | 727 | 382 |
P value = 2.75e-06 (Fisher's exact test), Q value = 0.0037
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
19P LOSS MUTATED | 46 | 400 |
19P LOSS WILD-TYPE | 780 | 3337 |
Cluster Labels | 19Q LOSS MUTATED | 19Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 362 | 4201 |
P value = 5.1e-64 (Chi-square test), Q value = 7.9e-61
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
19Q LOSS MUTATED | 3 | 22 | 51 | 14 | 23 | 17 | 1 | 86 | 1 | 137 | 0 | 7 |
19Q LOSS WILD-TYPE | 122 | 522 | 795 | 398 | 424 | 302 | 492 | 576 | 1 | 411 | 2 | 152 |
P value = 5.16e-07 (Fisher's exact test), Q value = 7e-04
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
19Q LOSS MUTATED | 272 | 90 |
19Q LOSS WILD-TYPE | 2609 | 1592 |
P value = 1.28e-50 (Chi-square test), Q value = 2e-47
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
19Q LOSS MUTATED | 13 | 1 | 9 | 17 | 1 | 2 | 13 | 27 | 0 | 0 | 2 | 0 | 0 | 0 | 3 | 1 | 0 | 1 | 2 | 34 | 2 | 1 | 6 | 0 | 138 | 12 | 0 | 3 |
19Q LOSS WILD-TYPE | 343 | 53 | 341 | 302 | 492 | 8 | 62 | 178 | 7 | 3 | 13 | 2 | 3 | 2 | 10 | 0 | 1 | 0 | 0 | 281 | 16 | 6 | 137 | 13 | 414 | 67 | 1 | 17 |
P value = 8.01e-10 (Chi-square test), Q value = 1.1e-06
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
19Q LOSS MUTATED | 48 | 37 | 139 | 34 |
19Q LOSS WILD-TYPE | 664 | 461 | 742 | 389 |
Cluster Labels | 20P LOSS MUTATED | 20P LOSS WILD-TYPE |
---|---|---|
Number of samples | 253 | 4310 |
P value = 1.02e-10 (Chi-square test), Q value = 1.4e-07
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
20P LOSS MUTATED | 3 | 12 | 48 | 33 | 15 | 21 | 6 | 60 | 0 | 35 | 0 | 19 |
20P LOSS WILD-TYPE | 122 | 532 | 798 | 379 | 432 | 298 | 487 | 602 | 2 | 513 | 2 | 140 |
P value = 5.75e-09 (Chi-square test), Q value = 8e-06
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
20P LOSS MUTATED | 31 | 2 | 7 | 21 | 6 | 1 | 11 | 28 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 16 | 1 | 1 | 17 | 2 | 35 | 7 | 0 | 0 |
20P LOSS WILD-TYPE | 325 | 52 | 343 | 298 | 487 | 9 | 64 | 177 | 7 | 3 | 14 | 2 | 2 | 2 | 13 | 1 | 1 | 1 | 1 | 299 | 17 | 6 | 126 | 11 | 517 | 72 | 1 | 20 |
Cluster Labels | 20Q LOSS MUTATED | 20Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 108 | 4455 |
P value = 9.63e-09 (Chi-square test), Q value = 1.3e-05
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
20Q LOSS MUTATED | 1 | 11 | 22 | 2 | 5 | 10 | 0 | 36 | 0 | 21 | 0 | 0 |
20Q LOSS WILD-TYPE | 124 | 533 | 824 | 410 | 442 | 309 | 493 | 626 | 2 | 527 | 2 | 159 |
P value = 8.42e-07 (Chi-square test), Q value = 0.0011
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
20Q LOSS MUTATED | 2 | 0 | 3 | 10 | 0 | 0 | 6 | 10 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 17 | 1 | 1 | 0 | 0 | 21 | 1 | 0 | 1 |
20Q LOSS WILD-TYPE | 354 | 54 | 347 | 309 | 493 | 10 | 69 | 195 | 7 | 3 | 14 | 2 | 2 | 2 | 13 | 1 | 1 | 1 | 2 | 298 | 17 | 6 | 143 | 13 | 531 | 78 | 1 | 19 |
Cluster Labels | 21Q LOSS MUTATED | 21Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 647 | 3916 |
P value = 2.1e-46 (Chi-square test), Q value = 3.2e-43
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
21Q LOSS MUTATED | 13 | 27 | 80 | 71 | 26 | 58 | 33 | 143 | 0 | 151 | 0 | 44 |
21Q LOSS WILD-TYPE | 112 | 517 | 766 | 341 | 421 | 261 | 460 | 519 | 2 | 397 | 2 | 115 |
P value = 1.61e-27 (Chi-square test), Q value = 2.4e-24
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
21Q LOSS MUTATED | 67 | 4 | 10 | 58 | 33 | 3 | 11 | 27 | 2 | 0 | 1 | 0 | 1 | 0 | 3 | 1 | 0 | 0 | 1 | 93 | 3 | 0 | 40 | 2 | 151 | 13 | 0 | 2 |
21Q LOSS WILD-TYPE | 289 | 50 | 340 | 261 | 460 | 7 | 64 | 178 | 5 | 3 | 14 | 2 | 2 | 2 | 10 | 0 | 1 | 1 | 1 | 222 | 15 | 7 | 103 | 11 | 401 | 66 | 1 | 18 |
P value = 5.65e-06 (Chi-square test), Q value = 0.0075
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
21Q LOSS MUTATED | 115 | 78 | 219 | 74 |
21Q LOSS WILD-TYPE | 597 | 420 | 662 | 349 |
P value = 1.08e-07 (Fisher's exact test), Q value = 0.00015
nPatients | NO | YES |
---|---|---|
ALL | 826 | 3737 |
21Q LOSS MUTATED | 71 | 576 |
21Q LOSS WILD-TYPE | 755 | 3161 |
P value = 5.24e-05 (t-test), Q value = 0.068
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 568 | 1995.2 (13.5) |
21Q LOSS MUTATED | 112 | 1999.2 (10.8) |
21Q LOSS WILD-TYPE | 456 | 1994.2 (13.9) |
Cluster Labels | 22Q LOSS MUTATED | 22Q LOSS WILD-TYPE |
---|---|---|
Number of samples | 1165 | 3398 |
P value = 5.47e-05 (logrank test), Q value = 0.071
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 4296 | 1401 | 0.0 - 224.0 (14.9) |
22Q LOSS MUTATED | 1090 | 427 | 0.0 - 224.0 (16.1) |
22Q LOSS WILD-TYPE | 3206 | 974 | 0.0 - 223.4 (14.2) |
P value = 2.28e-167 (Chi-square test), Q value = 3.6e-164
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
22Q LOSS MUTATED | 23 | 146 | 287 | 80 | 72 | 24 | 11 | 106 | 1 | 373 | 1 | 40 |
22Q LOSS WILD-TYPE | 102 | 398 | 559 | 332 | 375 | 295 | 482 | 556 | 1 | 175 | 1 | 119 |
P value = 5.59e-34 (Fisher's exact test), Q value = 8.4e-31
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
22Q LOSS MUTATED | 904 | 261 |
22Q LOSS WILD-TYPE | 1977 | 1421 |
P value = 8.78e-170 (Chi-square test), Q value = 1.4e-166
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
22Q LOSS MUTATED | 79 | 1 | 36 | 24 | 11 | 4 | 15 | 44 | 1 | 0 | 5 | 0 | 1 | 0 | 2 | 1 | 0 | 1 | 1 | 30 | 6 | 1 | 36 | 4 | 375 | 30 | 0 | 6 |
22Q LOSS WILD-TYPE | 277 | 53 | 314 | 295 | 482 | 6 | 60 | 161 | 6 | 3 | 10 | 2 | 2 | 2 | 11 | 0 | 1 | 0 | 1 | 285 | 12 | 6 | 107 | 9 | 177 | 49 | 1 | 14 |
P value = 3.92e-53 (Chi-square test), Q value = 6e-50
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
22Q LOSS MUTATED | 75 | 83 | 374 | 89 |
22Q LOSS WILD-TYPE | 637 | 415 | 507 | 334 |
Cluster Labels | XQ LOSS MUTATED | XQ LOSS WILD-TYPE |
---|---|---|
Number of samples | 200 | 4363 |
P value = 5.04e-48 (Chi-square test), Q value = 7.7e-45
nPatients | BLADDER | BRAIN | BREAST | COLON | ENDOMETRIAL | HEAD/NECK | KIDNEY | LUNG | OMENTUM | OVARY | PERITONEUM (OVARY) | RECTUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 125 | 544 | 846 | 412 | 447 | 319 | 493 | 662 | 2 | 548 | 2 | 159 |
XQ LOSS MUTATED | 2 | 10 | 30 | 5 | 13 | 8 | 11 | 21 | 1 | 93 | 0 | 5 |
XQ LOSS WILD-TYPE | 123 | 534 | 816 | 407 | 434 | 311 | 482 | 641 | 1 | 455 | 2 | 154 |
P value = 4.06e-07 (Fisher's exact test), Q value = 0.00055
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2881 | 1682 |
XQ LOSS MUTATED | 159 | 41 |
XQ LOSS WILD-TYPE | 2722 | 1641 |
P value = 5.42e-35 (Chi-square test), Q value = 8.2e-32
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | HEAD & NECK SQUAMOUS CELL CARCINOMA | KIDNEY CLEAR CELL RENAL CARCINOMA | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BASALOID SQUAMOUS CELL CARCINOMA | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARCINOMA | LUNG PAPILLARY SQUAMOUS CELL CARICNOMA | LUNG SMALL CELL SQUAMOUS CELL CARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | LUNG SQUAMOUS CELL CARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | MIXED SEROUS AND ENDOMETRIOID | MUCINOUS (COLLOID) ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA | SEROUS CYSTADENOCARCINOMA | SEROUS ENDOMETRIAL ADENOCARCINOMA | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 356 | 54 | 350 | 319 | 493 | 10 | 75 | 205 | 7 | 3 | 15 | 2 | 3 | 2 | 13 | 1 | 1 | 1 | 2 | 315 | 18 | 7 | 143 | 13 | 552 | 79 | 1 | 20 |
XQ LOSS MUTATED | 4 | 1 | 6 | 8 | 11 | 1 | 1 | 7 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 10 | 1 | 0 | 5 | 0 | 94 | 6 | 0 | 0 |
XQ LOSS WILD-TYPE | 352 | 53 | 344 | 311 | 482 | 9 | 74 | 198 | 7 | 3 | 15 | 1 | 3 | 2 | 13 | 1 | 1 | 0 | 2 | 305 | 17 | 7 | 138 | 13 | 458 | 73 | 1 | 20 |
P value = 2.78e-10 (Chi-square test), Q value = 3.9e-07
nPatients | I | II | III | IV |
---|---|---|---|---|
ALL | 712 | 498 | 881 | 423 |
XQ LOSS MUTATED | 21 | 14 | 87 | 20 |
XQ LOSS WILD-TYPE | 691 | 484 | 794 | 403 |
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Cluster data file = broad_values_by_arm.mutsig.cluster.txt
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Clinical data file = PANCAN12-TP.clin.merged.picked.txt
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Number of patients = 4563
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Number of clustering approaches = 80
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Number of selected clinical features = 21
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Exclude small clusters that include fewer than K patients, K = 3
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between two tumor subtypes using 't.test' function in R
For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.