This pipeline computes the correlation between significant copy number variation (cnv) genes and molecular subtypes.
Testing the association between copy number variation of 47 peak regions and 8 molecular subtypes across 187 patients, 47 significant findings detected with Q value < 0.25.
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Amp Peak 2(3q26.2) cnvs correlated to 'CN_CNMF'.
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Amp Peak 3(7p15.3) cnvs correlated to 'CN_CNMF'.
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Amp Peak 4(7q34) cnvs correlated to 'CN_CNMF'.
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Amp Peak 5(8p11.22) cnvs correlated to 'CN_CNMF'.
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Amp Peak 6(8q21.13) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
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Amp Peak 7(11q13.2) cnvs correlated to 'CN_CNMF'.
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Del Peak 1(1p31.3) cnvs correlated to 'METHLYATION_CNMF'.
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Del Peak 5(2q22.1) cnvs correlated to 'CN_CNMF' and 'MIRSEQ_CHIERARCHICAL'.
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Del Peak 8(4q28.2) cnvs correlated to 'CN_CNMF'.
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Del Peak 9(5q11.2) cnvs correlated to 'CN_CNMF'.
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Del Peak 10(5q21.1) cnvs correlated to 'CN_CNMF'.
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Del Peak 11(6q15) cnvs correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', and 'MIRSEQ_CNMF'.
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Del Peak 13(8p21.3) cnvs correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', and 'MIRSEQ_MATURE_CNMF'.
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Del Peak 14(8p11.21) cnvs correlated to 'METHLYATION_CNMF'.
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Del Peak 15(9p22.3) cnvs correlated to 'CN_CNMF'.
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Del Peak 16(10q23.31) cnvs correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
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Del Peak 18(12p13.2) cnvs correlated to 'CN_CNMF' and 'MIRSEQ_MATURE_CNMF'.
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Del Peak 19(13q14.13) cnvs correlated to 'CN_CNMF'.
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Del Peak 20(16q24.1) cnvs correlated to 'CN_CNMF'.
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Del Peak 21(17p13.1) cnvs correlated to 'CN_CNMF'.
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Del Peak 22(17q21.31) cnvs correlated to 'METHLYATION_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
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Del Peak 23(18q22.1) cnvs correlated to 'CN_CNMF'.
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Del Peak 24(18q23) cnvs correlated to 'CN_CNMF'.
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Del Peak 25(21q22.2) cnvs correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
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Del Peak 26(21q22.3) cnvs correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
Molecular subtypes |
CN CNMF |
METHLYATION CNMF |
MRNASEQ CNMF |
MRNASEQ CHIERARCHICAL |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRSEQ MATURE CNMF |
MIRSEQ MATURE CHIERARCHICAL |
||
nCNV (%) | nWild-Type | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Chi-square test | Fisher's exact test | |
Del Peak 11(6q15) | 0 (0%) | 128 |
2.58e-18 (9.72e-16) |
2.16e-08 (7.83e-06) |
1.13e-06 (0.000403) |
3.91e-05 (0.0136) |
4.64e-05 (0.0161) |
0.0325 (1.00) |
0.00441 (1.00) |
0.284 (1.00) |
Del Peak 13(8p21 3) | 0 (0%) | 79 |
1.68e-08 (6.1e-06) |
2.28e-06 (0.000805) |
6.83e-05 (0.0234) |
0.000164 (0.0557) |
0.0133 (1.00) |
0.304 (1.00) |
2.55e-05 (0.00891) |
0.0741 (1.00) |
Del Peak 16(10q23 31) | 0 (0%) | 122 |
7.27e-07 (0.00026) |
2.12e-07 (7.62e-05) |
4.72e-08 (1.71e-05) |
1e-06 (0.000359) |
0.0189 (1.00) |
0.115 (1.00) |
0.00192 (0.61) |
0.423 (1.00) |
Del Peak 25(21q22 2) | 0 (0%) | 126 |
1.94e-06 (0.000688) |
1.3e-12 (4.85e-10) |
6.59e-10 (2.41e-07) |
1.91e-12 (7.11e-10) |
0.0797 (1.00) |
0.017 (1.00) |
0.27 (1.00) |
0.118 (1.00) |
Del Peak 26(21q22 3) | 0 (0%) | 127 |
1.77e-06 (0.000627) |
2.54e-12 (9.41e-10) |
9.24e-11 (3.41e-08) |
8.05e-13 (3.01e-10) |
0.0301 (1.00) |
0.00157 (0.502) |
0.00442 (1.00) |
0.0251 (1.00) |
Del Peak 22(17q21 31) | 0 (0%) | 151 |
0.00697 (1.00) |
0.000116 (0.0397) |
2.6e-05 (0.00907) |
5.54e-05 (0.0191) |
0.0594 (1.00) |
0.211 (1.00) |
0.103 (1.00) |
0.495 (1.00) |
Amp Peak 6(8q21 13) | 0 (0%) | 141 |
4.82e-10 (1.77e-07) |
0.000648 (0.214) |
0.00137 (0.444) |
0.00784 (1.00) |
0.0717 (1.00) |
0.0448 (1.00) |
0.0857 (1.00) |
0.737 (1.00) |
Del Peak 5(2q22 1) | 0 (0%) | 165 |
6.01e-05 (0.0207) |
0.0296 (1.00) |
0.11 (1.00) |
0.033 (1.00) |
0.0262 (1.00) |
0.000266 (0.0897) |
0.0034 (1.00) |
0.0153 (1.00) |
Del Peak 18(12p13 2) | 0 (0%) | 148 |
7.1e-05 (0.0243) |
0.0161 (1.00) |
0.562 (1.00) |
0.0963 (1.00) |
0.307 (1.00) |
0.361 (1.00) |
0.000629 (0.208) |
0.881 (1.00) |
Amp Peak 2(3q26 2) | 0 (0%) | 160 |
0.0003 (0.101) |
0.453 (1.00) |
0.305 (1.00) |
0.495 (1.00) |
0.462 (1.00) |
0.22 (1.00) |
0.21 (1.00) |
0.24 (1.00) |
Amp Peak 3(7p15 3) | 0 (0%) | 152 |
3.5e-06 (0.00123) |
0.0447 (1.00) |
0.00785 (1.00) |
0.0135 (1.00) |
0.394 (1.00) |
0.876 (1.00) |
0.255 (1.00) |
0.22 (1.00) |
Amp Peak 4(7q34) | 0 (0%) | 155 |
0.000158 (0.0539) |
0.0141 (1.00) |
0.00179 (0.57) |
0.000969 (0.316) |
0.237 (1.00) |
0.752 (1.00) |
0.353 (1.00) |
0.247 (1.00) |
Amp Peak 5(8p11 22) | 0 (0%) | 170 |
1.44e-05 (0.00504) |
0.149 (1.00) |
0.0508 (1.00) |
0.268 (1.00) |
0.258 (1.00) |
0.386 (1.00) |
0.128 (1.00) |
0.86 (1.00) |
Amp Peak 7(11q13 2) | 0 (0%) | 176 |
0.000495 (0.165) |
0.445 (1.00) |
0.193 (1.00) |
0.355 (1.00) |
0.842 (1.00) |
0.62 (1.00) |
0.675 (1.00) |
0.802 (1.00) |
Del Peak 1(1p31 3) | 0 (0%) | 165 |
0.0439 (1.00) |
0.000408 (0.136) |
0.00169 (0.542) |
0.00458 (1.00) |
0.0262 (1.00) |
0.513 (1.00) |
0.226 (1.00) |
0.291 (1.00) |
Del Peak 8(4q28 2) | 0 (0%) | 170 |
0.000215 (0.0728) |
0.0131 (1.00) |
0.0149 (1.00) |
0.0943 (1.00) |
0.158 (1.00) |
0.144 (1.00) |
0.205 (1.00) |
0.163 (1.00) |
Del Peak 9(5q11 2) | 0 (0%) | 157 |
2.63e-07 (9.45e-05) |
0.00146 (0.471) |
0.0901 (1.00) |
0.0433 (1.00) |
0.0793 (1.00) |
0.59 (1.00) |
0.0108 (1.00) |
0.773 (1.00) |
Del Peak 10(5q21 1) | 0 (0%) | 154 |
9.42e-12 (3.49e-09) |
0.00104 (0.337) |
0.00269 (0.848) |
0.00737 (1.00) |
0.182 (1.00) |
0.42 (1.00) |
0.0083 (1.00) |
0.618 (1.00) |
Del Peak 14(8p11 21) | 0 (0%) | 128 |
0.0124 (1.00) |
3.15e-05 (0.011) |
0.000913 (0.3) |
0.0164 (1.00) |
0.361 (1.00) |
0.933 (1.00) |
0.0159 (1.00) |
0.511 (1.00) |
Del Peak 15(9p22 3) | 0 (0%) | 172 |
0.000599 (0.199) |
0.497 (1.00) |
0.216 (1.00) |
0.268 (1.00) |
0.615 (1.00) |
1 (1.00) |
0.759 (1.00) |
1 (1.00) |
Del Peak 19(13q14 13) | 0 (0%) | 104 |
0.00032 (0.107) |
0.00449 (1.00) |
0.00147 (0.473) |
0.00478 (1.00) |
0.412 (1.00) |
0.534 (1.00) |
0.0399 (1.00) |
0.631 (1.00) |
Del Peak 20(16q24 1) | 0 (0%) | 113 |
3.33e-10 (1.22e-07) |
0.0009 (0.296) |
0.0228 (1.00) |
0.0158 (1.00) |
0.0023 (0.728) |
0.0277 (1.00) |
0.0123 (1.00) |
0.355 (1.00) |
Del Peak 21(17p13 1) | 0 (0%) | 141 |
2.13e-09 (7.75e-07) |
0.054 (1.00) |
0.0284 (1.00) |
0.00411 (1.00) |
0.328 (1.00) |
0.242 (1.00) |
0.0087 (1.00) |
0.737 (1.00) |
Del Peak 23(18q22 1) | 0 (0%) | 141 |
7.86e-10 (2.87e-07) |
0.0983 (1.00) |
0.196 (1.00) |
0.449 (1.00) |
0.136 (1.00) |
0.215 (1.00) |
0.337 (1.00) |
0.298 (1.00) |
Del Peak 24(18q23) | 0 (0%) | 135 |
7.39e-14 (2.77e-11) |
0.0623 (1.00) |
0.0654 (1.00) |
0.136 (1.00) |
0.231 (1.00) |
0.799 (1.00) |
0.336 (1.00) |
0.675 (1.00) |
Amp Peak 1(1q21 3) | 0 (0%) | 175 |
0.0143 (1.00) |
0.311 (1.00) |
0.144 (1.00) |
0.124 (1.00) |
0.23 (1.00) |
0.521 (1.00) |
0.0243 (1.00) |
1 (1.00) |
Amp Peak 8(12q24 32) | 0 (0%) | 180 |
0.00207 (0.657) |
0.474 (1.00) |
0.894 (1.00) |
0.183 (1.00) |
0.895 (1.00) |
0.857 (1.00) |
0.297 (1.00) |
0.211 (1.00) |
Amp Peak 9(14q21 1) | 0 (0%) | 177 |
0.0333 (1.00) |
0.00532 (1.00) |
0.00905 (1.00) |
0.518 (1.00) |
0.241 (1.00) |
0.203 (1.00) |
0.47 (1.00) |
0.109 (1.00) |
Amp Peak 10(20q13 33) | 0 (0%) | 175 |
0.00575 (1.00) |
0.000936 (0.306) |
0.0118 (1.00) |
0.00956 (1.00) |
0.672 (1.00) |
0.0711 (1.00) |
0.0931 (1.00) |
1 (1.00) |
Amp Peak 11(21q21 3) | 0 (0%) | 180 |
0.0323 (1.00) |
0.215 (1.00) |
0.218 (1.00) |
0.288 (1.00) |
0.455 (1.00) |
0.534 (1.00) |
0.802 (1.00) |
0.53 (1.00) |
Amp Peak 12(Xp22 11) | 0 (0%) | 182 |
0.363 (1.00) |
0.671 (1.00) |
0.74 (1.00) |
0.606 (1.00) |
0.654 (1.00) |
0.0892 (1.00) |
0.158 (1.00) |
0.122 (1.00) |
Amp Peak 13(Xp22 11) | 0 (0%) | 182 |
0.726 (1.00) |
0.351 (1.00) |
1 (1.00) |
0.735 (1.00) |
0.545 (1.00) |
0.393 (1.00) |
0.293 (1.00) |
0.7 (1.00) |
Amp Peak 14(Xp21 1) | 0 (0%) | 183 |
0.68 (1.00) |
0.0794 (1.00) |
1 (1.00) |
1 (1.00) |
0.39 (1.00) |
0.507 (1.00) |
0.817 (1.00) |
0.396 (1.00) |
Amp Peak 15(Xq12) | 0 (0%) | 183 |
0.278 (1.00) |
0.486 (1.00) |
0.0637 (1.00) |
0.021 (1.00) |
0.593 (1.00) |
0.387 (1.00) |
0.657 (1.00) |
0.656 (1.00) |
Amp Peak 16(Xq21 1) | 0 (0%) | 180 |
0.39 (1.00) |
0.215 (1.00) |
0.199 (1.00) |
0.234 (1.00) |
0.776 (1.00) |
0.408 (1.00) |
0.663 (1.00) |
0.361 (1.00) |
Amp Peak 17(Xq21 1) | 0 (0%) | 182 |
0.363 (1.00) |
0.122 (1.00) |
0.529 (1.00) |
0.332 (1.00) |
0.82 (1.00) |
0.716 (1.00) |
0.568 (1.00) |
1 (1.00) |
Amp Peak 18(Xq21 31) | 0 (0%) | 182 |
0.139 (1.00) |
0.476 (1.00) |
0.325 (1.00) |
0.138 (1.00) |
0.937 (1.00) |
0.853 (1.00) |
0.607 (1.00) |
0.7 (1.00) |
Amp Peak 19(Xq25) | 0 (0%) | 183 |
0.0497 (1.00) |
0.583 (1.00) |
0.391 (1.00) |
0.173 (1.00) |
0.317 (1.00) |
0.172 (1.00) |
0.0606 (1.00) |
0.198 (1.00) |
Amp Peak 20(Xq25) | 0 (0%) | 181 |
1 (1.00) |
0.0725 (1.00) |
0.118 (1.00) |
0.5 (1.00) |
0.54 (1.00) |
0.269 (1.00) |
0.468 (1.00) |
0.492 (1.00) |
Amp Peak 21(Xq27 1) | 0 (0%) | 178 |
0.00666 (1.00) |
0.624 (1.00) |
0.835 (1.00) |
0.831 (1.00) |
0.0296 (1.00) |
0.0345 (1.00) |
0.0121 (1.00) |
0.00988 (1.00) |
Del Peak 2(1p21 3) | 0 (0%) | 171 |
0.00945 (1.00) |
0.648 (1.00) |
0.945 (1.00) |
1 (1.00) |
0.446 (1.00) |
0.609 (1.00) |
0.194 (1.00) |
0.163 (1.00) |
Del Peak 3(1q23 1) | 0 (0%) | 179 |
0.096 (1.00) |
0.138 (1.00) |
0.136 (1.00) |
0.111 (1.00) |
0.0916 (1.00) |
0.0422 (1.00) |
0.279 (1.00) |
0.136 (1.00) |
Del Peak 4(1q42 13) | 0 (0%) | 169 |
0.448 (1.00) |
0.0973 (1.00) |
0.73 (1.00) |
0.807 (1.00) |
0.85 (1.00) |
0.534 (1.00) |
0.481 (1.00) |
1 (1.00) |
Del Peak 6(3p13) | 0 (0%) | 159 |
0.668 (1.00) |
0.0336 (1.00) |
0.294 (1.00) |
0.0302 (1.00) |
0.193 (1.00) |
0.856 (1.00) |
0.433 (1.00) |
0.106 (1.00) |
Del Peak 7(3q29) | 0 (0%) | 175 |
0.768 (1.00) |
0.0689 (1.00) |
0.0694 (1.00) |
0.0229 (1.00) |
0.851 (1.00) |
0.855 (1.00) |
0.618 (1.00) |
0.53 (1.00) |
Del Peak 12(7q36 1) | 0 (0%) | 178 |
0.382 (1.00) |
0.139 (1.00) |
0.596 (1.00) |
0.483 (1.00) |
0.289 (1.00) |
0.481 (1.00) |
0.523 (1.00) |
0.784 (1.00) |
Del Peak 17(11q23 2) | 0 (0%) | 164 |
0.0629 (1.00) |
0.482 (1.00) |
0.877 (1.00) |
0.916 (1.00) |
0.0966 (1.00) |
0.346 (1.00) |
0.258 (1.00) |
0.897 (1.00) |
P value = 3e-04 (Fisher's exact test), Q value = 0.1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
AMP PEAK 2(3Q26.2) CNV | 7 | 4 | 16 | 0 |
AMP PEAK 2(3Q26.2) WILD-TYPE | 27 | 88 | 43 | 2 |
P value = 3.5e-06 (Fisher's exact test), Q value = 0.0012
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
AMP PEAK 3(7P15.3) CNV | 5 | 6 | 23 | 1 |
AMP PEAK 3(7P15.3) WILD-TYPE | 29 | 86 | 36 | 1 |
P value = 0.000158 (Fisher's exact test), Q value = 0.054
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
AMP PEAK 4(7Q34) CNV | 6 | 6 | 19 | 1 |
AMP PEAK 4(7Q34) WILD-TYPE | 28 | 86 | 40 | 1 |
P value = 1.44e-05 (Fisher's exact test), Q value = 0.005
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
AMP PEAK 5(8P11.22) CNV | 2 | 1 | 13 | 1 |
AMP PEAK 5(8P11.22) WILD-TYPE | 32 | 91 | 46 | 1 |
P value = 4.82e-10 (Fisher's exact test), Q value = 1.8e-07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
AMP PEAK 6(8Q21.13) CNV | 6 | 7 | 32 | 1 |
AMP PEAK 6(8Q21.13) WILD-TYPE | 28 | 85 | 27 | 1 |
P value = 0.000648 (Fisher's exact test), Q value = 0.21
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 57 | 57 | 55 | 18 |
AMP PEAK 6(8Q21.13) CNV | 24 | 13 | 5 | 4 |
AMP PEAK 6(8Q21.13) WILD-TYPE | 33 | 44 | 50 | 14 |
P value = 0.000495 (Fisher's exact test), Q value = 0.16
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
AMP PEAK 7(11Q13.2) CNV | 0 | 1 | 10 | 0 |
AMP PEAK 7(11Q13.2) WILD-TYPE | 34 | 91 | 49 | 2 |
P value = 0.000408 (Fisher's exact test), Q value = 0.14
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 57 | 57 | 55 | 18 |
DEL PEAK 1(1P31.3) CNV | 4 | 15 | 1 | 2 |
DEL PEAK 1(1P31.3) WILD-TYPE | 53 | 42 | 54 | 16 |
P value = 6.01e-05 (Fisher's exact test), Q value = 0.021
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 5(2Q22.1) CNV | 8 | 2 | 11 | 1 |
DEL PEAK 5(2Q22.1) WILD-TYPE | 26 | 90 | 48 | 1 |
P value = 0.000266 (Fisher's exact test), Q value = 0.09
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 32 | 64 | 90 |
DEL PEAK 5(2Q22.1) CNV | 2 | 1 | 19 |
DEL PEAK 5(2Q22.1) WILD-TYPE | 30 | 63 | 71 |
P value = 0.000215 (Fisher's exact test), Q value = 0.073
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 8(4Q28.2) CNV | 4 | 1 | 12 | 0 |
DEL PEAK 8(4Q28.2) WILD-TYPE | 30 | 91 | 47 | 2 |
P value = 2.63e-07 (Fisher's exact test), Q value = 9.4e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 9(5Q11.2) CNV | 9 | 2 | 19 | 0 |
DEL PEAK 9(5Q11.2) WILD-TYPE | 25 | 90 | 40 | 2 |
P value = 9.42e-12 (Fisher's exact test), Q value = 3.5e-09
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 10(5Q21.1) CNV | 14 | 0 | 19 | 0 |
DEL PEAK 10(5Q21.1) WILD-TYPE | 20 | 92 | 40 | 2 |
P value = 2.58e-18 (Fisher's exact test), Q value = 9.7e-16
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 11(6Q15) CNV | 27 | 4 | 27 | 1 |
DEL PEAK 11(6Q15) WILD-TYPE | 7 | 88 | 32 | 1 |
P value = 2.16e-08 (Fisher's exact test), Q value = 7.8e-06
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 57 | 57 | 55 | 18 |
DEL PEAK 11(6Q15) CNV | 34 | 16 | 4 | 5 |
DEL PEAK 11(6Q15) WILD-TYPE | 23 | 41 | 51 | 13 |
P value = 1.13e-06 (Fisher's exact test), Q value = 4e-04
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 59 | 53 | 63 |
DEL PEAK 11(6Q15) CNV | 32 | 5 | 18 |
DEL PEAK 11(6Q15) WILD-TYPE | 27 | 48 | 45 |
P value = 3.91e-05 (Fisher's exact test), Q value = 0.014
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 49 | 75 | 51 |
DEL PEAK 11(6Q15) CNV | 26 | 23 | 6 |
DEL PEAK 11(6Q15) WILD-TYPE | 23 | 52 | 45 |
P value = 4.64e-05 (Fisher's exact test), Q value = 0.016
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 52 | 51 | 28 | 55 |
DEL PEAK 11(6Q15) CNV | 27 | 5 | 8 | 18 |
DEL PEAK 11(6Q15) WILD-TYPE | 25 | 46 | 20 | 37 |
P value = 1.68e-08 (Fisher's exact test), Q value = 6.1e-06
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 13(8P21.3) CNV | 17 | 38 | 52 | 1 |
DEL PEAK 13(8P21.3) WILD-TYPE | 17 | 54 | 7 | 1 |
P value = 2.28e-06 (Fisher's exact test), Q value = 8e-04
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 57 | 57 | 55 | 18 |
DEL PEAK 13(8P21.3) CNV | 33 | 43 | 17 | 15 |
DEL PEAK 13(8P21.3) WILD-TYPE | 24 | 14 | 38 | 3 |
P value = 6.83e-05 (Fisher's exact test), Q value = 0.023
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 59 | 53 | 63 |
DEL PEAK 13(8P21.3) CNV | 30 | 24 | 51 |
DEL PEAK 13(8P21.3) WILD-TYPE | 29 | 29 | 12 |
P value = 0.000164 (Fisher's exact test), Q value = 0.056
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 49 | 75 | 51 |
DEL PEAK 13(8P21.3) CNV | 25 | 58 | 22 |
DEL PEAK 13(8P21.3) WILD-TYPE | 24 | 17 | 29 |
P value = 2.55e-05 (Chi-square test), Q value = 0.0089
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 44 | 30 | 32 | 22 | 58 |
DEL PEAK 13(8P21.3) CNV | 33 | 7 | 22 | 8 | 37 |
DEL PEAK 13(8P21.3) WILD-TYPE | 11 | 23 | 10 | 14 | 21 |
P value = 3.15e-05 (Fisher's exact test), Q value = 0.011
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 57 | 57 | 55 | 18 |
DEL PEAK 14(8P11.21) CNV | 19 | 26 | 5 | 9 |
DEL PEAK 14(8P11.21) WILD-TYPE | 38 | 31 | 50 | 9 |
P value = 0.000599 (Fisher's exact test), Q value = 0.2
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 15(9P22.3) CNV | 0 | 3 | 12 | 0 |
DEL PEAK 15(9P22.3) WILD-TYPE | 34 | 89 | 47 | 2 |
P value = 7.27e-07 (Fisher's exact test), Q value = 0.00026
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 16(10Q23.31) CNV | 4 | 24 | 36 | 1 |
DEL PEAK 16(10Q23.31) WILD-TYPE | 30 | 68 | 23 | 1 |
P value = 2.12e-07 (Fisher's exact test), Q value = 7.6e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 57 | 57 | 55 | 18 |
DEL PEAK 16(10Q23.31) CNV | 13 | 35 | 8 | 9 |
DEL PEAK 16(10Q23.31) WILD-TYPE | 44 | 22 | 47 | 9 |
P value = 4.72e-08 (Fisher's exact test), Q value = 1.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 59 | 53 | 63 |
DEL PEAK 16(10Q23.31) CNV | 13 | 9 | 40 |
DEL PEAK 16(10Q23.31) WILD-TYPE | 46 | 44 | 23 |
P value = 1e-06 (Fisher's exact test), Q value = 0.00036
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 49 | 75 | 51 |
DEL PEAK 16(10Q23.31) CNV | 10 | 43 | 9 |
DEL PEAK 16(10Q23.31) WILD-TYPE | 39 | 32 | 42 |
P value = 7.1e-05 (Fisher's exact test), Q value = 0.024
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 18(12P13.2) CNV | 6 | 9 | 24 | 0 |
DEL PEAK 18(12P13.2) WILD-TYPE | 28 | 83 | 35 | 2 |
P value = 0.000629 (Chi-square test), Q value = 0.21
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 44 | 30 | 32 | 22 | 58 |
DEL PEAK 18(12P13.2) CNV | 15 | 1 | 12 | 2 | 8 |
DEL PEAK 18(12P13.2) WILD-TYPE | 29 | 29 | 20 | 20 | 50 |
P value = 0.00032 (Fisher's exact test), Q value = 0.11
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 19(13Q14.13) CNV | 21 | 27 | 34 | 1 |
DEL PEAK 19(13Q14.13) WILD-TYPE | 13 | 65 | 25 | 1 |
P value = 3.33e-10 (Fisher's exact test), Q value = 1.2e-07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 20(16Q24.1) CNV | 7 | 23 | 44 | 0 |
DEL PEAK 20(16Q24.1) WILD-TYPE | 27 | 69 | 15 | 2 |
P value = 2.13e-09 (Fisher's exact test), Q value = 7.8e-07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 21(17P13.1) CNV | 3 | 10 | 32 | 1 |
DEL PEAK 21(17P13.1) WILD-TYPE | 31 | 82 | 27 | 1 |
P value = 0.000116 (Fisher's exact test), Q value = 0.04
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 57 | 57 | 55 | 18 |
DEL PEAK 22(17Q21.31) CNV | 5 | 22 | 5 | 4 |
DEL PEAK 22(17Q21.31) WILD-TYPE | 52 | 35 | 50 | 14 |
P value = 2.6e-05 (Fisher's exact test), Q value = 0.0091
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 59 | 53 | 63 |
DEL PEAK 22(17Q21.31) CNV | 6 | 4 | 24 |
DEL PEAK 22(17Q21.31) WILD-TYPE | 53 | 49 | 39 |
P value = 5.54e-05 (Fisher's exact test), Q value = 0.019
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 49 | 75 | 51 |
DEL PEAK 22(17Q21.31) CNV | 3 | 26 | 5 |
DEL PEAK 22(17Q21.31) WILD-TYPE | 46 | 49 | 46 |
P value = 7.86e-10 (Fisher's exact test), Q value = 2.9e-07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 23(18Q22.1) CNV | 3 | 10 | 33 | 0 |
DEL PEAK 23(18Q22.1) WILD-TYPE | 31 | 82 | 26 | 2 |
P value = 7.39e-14 (Fisher's exact test), Q value = 2.8e-11
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 24(18Q23) CNV | 4 | 9 | 39 | 0 |
DEL PEAK 24(18Q23) WILD-TYPE | 30 | 83 | 20 | 2 |
P value = 1.94e-06 (Fisher's exact test), Q value = 0.00069
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 25(21Q22.2) CNV | 0 | 37 | 23 | 1 |
DEL PEAK 25(21Q22.2) WILD-TYPE | 34 | 55 | 36 | 1 |
P value = 1.3e-12 (Fisher's exact test), Q value = 4.8e-10
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 57 | 57 | 55 | 18 |
DEL PEAK 25(21Q22.2) CNV | 4 | 33 | 10 | 14 |
DEL PEAK 25(21Q22.2) WILD-TYPE | 53 | 24 | 45 | 4 |
P value = 6.59e-10 (Fisher's exact test), Q value = 2.4e-07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 59 | 53 | 63 |
DEL PEAK 25(21Q22.2) CNV | 5 | 14 | 39 |
DEL PEAK 25(21Q22.2) WILD-TYPE | 54 | 39 | 24 |
P value = 1.91e-12 (Fisher's exact test), Q value = 7.1e-10
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 49 | 75 | 51 |
DEL PEAK 25(21Q22.2) CNV | 2 | 46 | 10 |
DEL PEAK 25(21Q22.2) WILD-TYPE | 47 | 29 | 41 |
P value = 1.77e-06 (Fisher's exact test), Q value = 0.00063
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 34 | 92 | 59 | 2 |
DEL PEAK 26(21Q22.3) CNV | 0 | 38 | 22 | 0 |
DEL PEAK 26(21Q22.3) WILD-TYPE | 34 | 54 | 37 | 2 |
P value = 2.54e-12 (Fisher's exact test), Q value = 9.4e-10
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 57 | 57 | 55 | 18 |
DEL PEAK 26(21Q22.3) CNV | 5 | 31 | 9 | 15 |
DEL PEAK 26(21Q22.3) WILD-TYPE | 52 | 26 | 46 | 3 |
P value = 9.24e-11 (Fisher's exact test), Q value = 3.4e-08
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 59 | 53 | 63 |
DEL PEAK 26(21Q22.3) CNV | 5 | 12 | 40 |
DEL PEAK 26(21Q22.3) WILD-TYPE | 54 | 41 | 23 |
P value = 8.05e-13 (Fisher's exact test), Q value = 3e-10
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 49 | 75 | 51 |
DEL PEAK 26(21Q22.3) CNV | 2 | 46 | 9 |
DEL PEAK 26(21Q22.3) WILD-TYPE | 47 | 29 | 42 |
-
Copy number data file = All Lesions File (all_lesions.conf_##.txt, where ## is the confidence level). The all lesions file is from GISTIC pipeline and summarizes the results from the GISTIC run. It contains data about the significant regions of amplification and deletion as well as which samples are amplified or deleted in each of these regions. The identified regions are listed down the first column, and the samples are listed across the first row, starting in column 10.
-
Molecular subtype file = PRAD-TP.transferedmergedcluster.txt
-
Number of patients = 187
-
Number of copy number variation regions = 47
-
Number of molecular subtypes = 8
-
Exclude regions that fewer than K tumors have alterations, K = 3
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.