This pipeline computes the correlation between significant copy number variation (cnv) genes and molecular subtypes.
Testing the association between copy number variation of 62 peak regions and 12 molecular subtypes across 162 patients, 16 significant findings detected with Q value < 0.25.
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Amp Peak 4(6p21.1) cnvs correlated to 'CN_CNMF'.
-
Amp Peak 5(8p11.23) cnvs correlated to 'CN_CNMF'.
-
Amp Peak 6(8p11.21) cnvs correlated to 'CN_CNMF'.
-
Amp Peak 7(8q24.21) cnvs correlated to 'CN_CNMF'.
-
Amp Peak 13(13q12.13) cnvs correlated to 'CN_CNMF'.
-
Amp Peak 14(13q12.2) cnvs correlated to 'CN_CNMF'.
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Amp Peak 15(13q22.1) cnvs correlated to 'CN_CNMF'.
-
Amp Peak 17(16p11.2) cnvs correlated to 'CN_CNMF'.
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Amp Peak 18(17q12) cnvs correlated to 'CN_CNMF'.
-
Amp Peak 19(17q24.1) cnvs correlated to 'CN_CNMF'.
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Del Peak 3(1p13.2) cnvs correlated to 'CN_CNMF'.
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Del Peak 8(4q22.1) cnvs correlated to 'CN_CNMF'.
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Del Peak 15(8p23.2) cnvs correlated to 'CN_CNMF'.
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Del Peak 24(15q22.33) cnvs correlated to 'CN_CNMF'.
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Del Peak 30(18q21.2) cnvs correlated to 'CN_CNMF'.
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Del Peak 31(18q22.1) cnvs correlated to 'CN_CNMF'.
Molecular subtypes |
MRNA CNMF |
MRNA CHIERARCHICAL |
CN CNMF |
METHLYATION CNMF |
RPPA CNMF |
RPPA CHIERARCHICAL |
MRNASEQ CNMF |
MRNASEQ CHIERARCHICAL |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRSEQ MATURE CNMF |
MIRSEQ MATURE CHIERARCHICAL |
||
nCNV (%) | nWild-Type | Fisher's exact test | Fisher's exact test | Chi-square test | Fisher's exact test | Fisher's exact test | Chi-square test | Chi-square test | Fisher's exact test | Chi-square test | Fisher's exact test | Fisher's exact test | Chi-square test | |
Amp Peak 4(6p21 1) | 0 (0%) | 110 |
0.0305 (1.00) |
0.0161 (1.00) |
0.000112 (0.0812) |
0.0497 (1.00) |
0.912 (1.00) |
0.1 (1.00) |
0.738 (1.00) |
0.747 (1.00) |
0.163 (1.00) |
0.413 (1.00) |
0.677 (1.00) |
0.987 (1.00) |
Amp Peak 5(8p11 23) | 0 (0%) | 110 |
0.00313 (1.00) |
0.283 (1.00) |
2.54e-08 (1.86e-05) |
0.306 (1.00) |
0.376 (1.00) |
0.376 (1.00) |
0.662 (1.00) |
0.823 (1.00) |
0.0568 (1.00) |
0.00668 (1.00) |
0.492 (1.00) |
0.191 (1.00) |
Amp Peak 6(8p11 21) | 0 (0%) | 93 |
0.0123 (1.00) |
0.0875 (1.00) |
2.38e-13 (1.75e-10) |
0.0935 (1.00) |
0.371 (1.00) |
0.5 (1.00) |
0.377 (1.00) |
0.935 (1.00) |
0.173 (1.00) |
0.084 (1.00) |
0.39 (1.00) |
0.11 (1.00) |
Amp Peak 7(8q24 21) | 0 (0%) | 55 |
0.0165 (1.00) |
0.0726 (1.00) |
1.7e-09 (1.25e-06) |
0.0452 (1.00) |
0.629 (1.00) |
0.59 (1.00) |
0.444 (1.00) |
0.627 (1.00) |
0.566 (1.00) |
0.144 (1.00) |
0.638 (1.00) |
0.153 (1.00) |
Amp Peak 13(13q12 13) | 0 (0%) | 41 |
0.416 (1.00) |
1 (1.00) |
3.06e-05 (0.0222) |
0.456 (1.00) |
0.424 (1.00) |
0.427 (1.00) |
0.0118 (1.00) |
0.241 (1.00) |
0.0122 (1.00) |
0.00847 (1.00) |
0.31 (1.00) |
0.458 (1.00) |
Amp Peak 14(13q12 2) | 0 (0%) | 42 |
0.363 (1.00) |
0.889 (1.00) |
4.86e-06 (0.00355) |
0.311 (1.00) |
0.736 (1.00) |
0.548 (1.00) |
0.0325 (1.00) |
0.423 (1.00) |
0.0737 (1.00) |
0.0227 (1.00) |
0.0371 (1.00) |
0.425 (1.00) |
Amp Peak 15(13q22 1) | 0 (0%) | 45 |
0.265 (1.00) |
0.645 (1.00) |
1.02e-07 (7.48e-05) |
0.0811 (1.00) |
0.907 (1.00) |
0.14 (1.00) |
0.372 (1.00) |
0.418 (1.00) |
0.00712 (1.00) |
0.00304 (1.00) |
0.0306 (1.00) |
0.0945 (1.00) |
Amp Peak 17(16p11 2) | 0 (0%) | 117 |
0.0674 (1.00) |
0.59 (1.00) |
2.96e-05 (0.0215) |
0.252 (1.00) |
0.3 (1.00) |
0.306 (1.00) |
0.388 (1.00) |
0.789 (1.00) |
0.178 (1.00) |
0.816 (1.00) |
0.202 (1.00) |
0.123 (1.00) |
Amp Peak 18(17q12) | 0 (0%) | 119 |
0.00641 (1.00) |
0.196 (1.00) |
0.0002 (0.145) |
0.502 (1.00) |
0.176 (1.00) |
0.895 (1.00) |
0.356 (1.00) |
0.146 (1.00) |
0.171 (1.00) |
0.898 (1.00) |
0.469 (1.00) |
0.816 (1.00) |
Amp Peak 19(17q24 1) | 0 (0%) | 125 |
0.291 (1.00) |
0.942 (1.00) |
0.000331 (0.238) |
0.121 (1.00) |
0.608 (1.00) |
0.63 (1.00) |
0.569 (1.00) |
0.236 (1.00) |
0.599 (1.00) |
0.668 (1.00) |
0.786 (1.00) |
0.699 (1.00) |
Del Peak 3(1p13 2) | 0 (0%) | 111 |
0.697 (1.00) |
0.0287 (1.00) |
0.000178 (0.129) |
0.353 (1.00) |
0.544 (1.00) |
0.739 (1.00) |
0.181 (1.00) |
0.5 (1.00) |
0.404 (1.00) |
0.104 (1.00) |
0.883 (1.00) |
0.827 (1.00) |
Del Peak 8(4q22 1) | 0 (0%) | 90 |
0.787 (1.00) |
0.1 (1.00) |
9.65e-05 (0.07) |
0.114 (1.00) |
0.702 (1.00) |
0.711 (1.00) |
0.0246 (1.00) |
0.0556 (1.00) |
0.917 (1.00) |
0.0816 (1.00) |
0.952 (1.00) |
0.403 (1.00) |
Del Peak 15(8p23 2) | 0 (0%) | 62 |
0.111 (1.00) |
0.0638 (1.00) |
6.4e-06 (0.00466) |
0.0456 (1.00) |
1 (1.00) |
0.582 (1.00) |
0.0289 (1.00) |
0.23 (1.00) |
0.643 (1.00) |
0.863 (1.00) |
0.544 (1.00) |
0.45 (1.00) |
Del Peak 24(15q22 33) | 0 (0%) | 87 |
0.72 (1.00) |
0.0793 (1.00) |
0.000218 (0.157) |
0.605 (1.00) |
0.194 (1.00) |
0.215 (1.00) |
0.26 (1.00) |
0.51 (1.00) |
0.384 (1.00) |
0.777 (1.00) |
0.683 (1.00) |
0.735 (1.00) |
Del Peak 30(18q21 2) | 0 (0%) | 19 |
0.132 (1.00) |
0.123 (1.00) |
5.18e-06 (0.00378) |
0.152 (1.00) |
1 (1.00) |
0.573 (1.00) |
0.12 (1.00) |
0.423 (1.00) |
0.433 (1.00) |
0.231 (1.00) |
0.581 (1.00) |
0.861 (1.00) |
Del Peak 31(18q22 1) | 0 (0%) | 24 |
0.0671 (1.00) |
0.0605 (1.00) |
2.38e-07 (0.000174) |
0.0366 (1.00) |
0.776 (1.00) |
0.484 (1.00) |
0.00538 (1.00) |
0.475 (1.00) |
0.805 (1.00) |
0.493 (1.00) |
0.0159 (1.00) |
0.435 (1.00) |
Amp Peak 1(1q21 3) | 0 (0%) | 114 |
1 (1.00) |
0.63 (1.00) |
0.000676 (0.483) |
0.619 (1.00) |
0.531 (1.00) |
0.18 (1.00) |
0.776 (1.00) |
0.0138 (1.00) |
0.0805 (1.00) |
0.646 (1.00) |
0.0818 (1.00) |
0.893 (1.00) |
Amp Peak 2(1q32 2) | 0 (0%) | 114 |
0.827 (1.00) |
0.88 (1.00) |
0.00918 (1.00) |
0.575 (1.00) |
0.185 (1.00) |
0.0535 (1.00) |
0.912 (1.00) |
0.0667 (1.00) |
0.11 (1.00) |
0.39 (1.00) |
0.0179 (1.00) |
0.696 (1.00) |
Amp Peak 3(5q22 3) | 0 (0%) | 143 |
0.0141 (1.00) |
0.566 (1.00) |
0.118 (1.00) |
0.254 (1.00) |
0.159 (1.00) |
0.445 (1.00) |
0.0738 (1.00) |
0.215 (1.00) |
0.485 (1.00) |
0.65 (1.00) |
0.0569 (1.00) |
0.278 (1.00) |
Amp Peak 8(10q22 2) | 0 (0%) | 151 |
0.502 (1.00) |
0.865 (1.00) |
0.912 (1.00) |
1 (1.00) |
1 (1.00) |
0.694 (1.00) |
0.387 (1.00) |
0.28 (1.00) |
0.594 (1.00) |
0.861 (1.00) |
||
Amp Peak 9(11p15 5) | 0 (0%) | 119 |
0.536 (1.00) |
0.775 (1.00) |
0.0286 (1.00) |
0.873 (1.00) |
0.697 (1.00) |
0.696 (1.00) |
0.00835 (1.00) |
0.00295 (1.00) |
0.0902 (1.00) |
0.47 (1.00) |
0.6 (1.00) |
0.00644 (1.00) |
Amp Peak 10(11q13 3) | 0 (0%) | 136 |
0.0613 (1.00) |
0.0402 (1.00) |
0.000568 (0.408) |
0.00267 (1.00) |
0.906 (1.00) |
0.861 (1.00) |
0.105 (1.00) |
0.67 (1.00) |
0.0151 (1.00) |
0.136 (1.00) |
0.674 (1.00) |
0.66 (1.00) |
Amp Peak 11(12p13 33) | 0 (0%) | 121 |
0.69 (1.00) |
1 (1.00) |
0.0385 (1.00) |
0.512 (1.00) |
0.113 (1.00) |
0.0558 (1.00) |
0.452 (1.00) |
0.241 (1.00) |
0.593 (1.00) |
0.84 (1.00) |
0.18 (1.00) |
0.463 (1.00) |
Amp Peak 12(12p12 1) | 0 (0%) | 122 |
0.697 (1.00) |
1 (1.00) |
0.036 (1.00) |
0.488 (1.00) |
0.0503 (1.00) |
0.0273 (1.00) |
0.605 (1.00) |
0.197 (1.00) |
0.681 (1.00) |
0.42 (1.00) |
0.0552 (1.00) |
0.515 (1.00) |
Amp Peak 16(15q26 1) | 0 (0%) | 147 |
0.183 (1.00) |
0.155 (1.00) |
0.314 (1.00) |
0.49 (1.00) |
0.101 (1.00) |
0.244 (1.00) |
0.189 (1.00) |
0.215 (1.00) |
0.503 (1.00) |
0.919 (1.00) |
0.454 (1.00) |
0.278 (1.00) |
Amp Peak 20(19p13 2) | 0 (0%) | 130 |
0.0202 (1.00) |
0.00871 (1.00) |
0.000599 (0.429) |
0.673 (1.00) |
0.389 (1.00) |
0.259 (1.00) |
0.153 (1.00) |
0.531 (1.00) |
0.643 (1.00) |
0.916 (1.00) |
0.606 (1.00) |
0.602 (1.00) |
Amp Peak 21(20q11 21) | 0 (0%) | 19 |
0.00777 (1.00) |
0.376 (1.00) |
0.00116 (0.824) |
0.0342 (1.00) |
0.194 (1.00) |
0.0766 (1.00) |
0.552 (1.00) |
0.271 (1.00) |
0.0283 (1.00) |
0.0916 (1.00) |
0.0125 (1.00) |
0.309 (1.00) |
Amp Peak 22(20q11 23) | 0 (0%) | 18 |
0.00777 (1.00) |
0.376 (1.00) |
0.00257 (1.00) |
0.094 (1.00) |
0.194 (1.00) |
0.0766 (1.00) |
0.552 (1.00) |
0.271 (1.00) |
0.0504 (1.00) |
0.0697 (1.00) |
0.0332 (1.00) |
0.493 (1.00) |
Amp Peak 23(20q13 31) | 0 (0%) | 17 |
0.00462 (1.00) |
0.31 (1.00) |
0.00544 (1.00) |
0.094 (1.00) |
0.194 (1.00) |
0.0766 (1.00) |
0.552 (1.00) |
0.271 (1.00) |
0.0728 (1.00) |
0.109 (1.00) |
0.0332 (1.00) |
0.493 (1.00) |
Amp Peak 24(Xp22 2) | 0 (0%) | 129 |
0.0247 (1.00) |
0.056 (1.00) |
0.644 (1.00) |
0.504 (1.00) |
0.795 (1.00) |
0.66 (1.00) |
0.991 (1.00) |
1 (1.00) |
0.775 (1.00) |
0.955 (1.00) |
0.166 (1.00) |
0.28 (1.00) |
Amp Peak 25(Xq27 3) | 0 (0%) | 124 |
0.209 (1.00) |
0.564 (1.00) |
0.0252 (1.00) |
0.0389 (1.00) |
0.586 (1.00) |
0.182 (1.00) |
0.252 (1.00) |
0.702 (1.00) |
0.56 (1.00) |
0.442 (1.00) |
0.185 (1.00) |
0.424 (1.00) |
Del Peak 1(1p36 11) | 0 (0%) | 91 |
0.24 (1.00) |
0.0255 (1.00) |
0.429 (1.00) |
0.0677 (1.00) |
0.803 (1.00) |
0.801 (1.00) |
0.569 (1.00) |
1 (1.00) |
0.467 (1.00) |
0.755 (1.00) |
0.9 (1.00) |
0.938 (1.00) |
Del Peak 2(1p33) | 0 (0%) | 113 |
0.626 (1.00) |
0.00289 (1.00) |
0.00196 (1.00) |
0.0563 (1.00) |
0.88 (1.00) |
0.247 (1.00) |
0.661 (1.00) |
1 (1.00) |
0.369 (1.00) |
0.187 (1.00) |
0.937 (1.00) |
0.691 (1.00) |
Del Peak 4(2p12) | 0 (0%) | 145 |
0.393 (1.00) |
0.467 (1.00) |
0.0623 (1.00) |
0.884 (1.00) |
0.344 (1.00) |
0.171 (1.00) |
0.655 (1.00) |
1 (1.00) |
0.37 (1.00) |
0.62 (1.00) |
0.515 (1.00) |
0.568 (1.00) |
Del Peak 5(3p14 2) | 0 (0%) | 133 |
0.8 (1.00) |
0.491 (1.00) |
0.606 (1.00) |
0.833 (1.00) |
0.217 (1.00) |
0.694 (1.00) |
0.268 (1.00) |
0.319 (1.00) |
0.832 (1.00) |
1 (1.00) |
0.519 (1.00) |
0.651 (1.00) |
Del Peak 6(3q26 31) | 0 (0%) | 145 |
1 (1.00) |
0.383 (1.00) |
0.604 (1.00) |
1 (1.00) |
0.746 (1.00) |
0.703 (1.00) |
0.242 (1.00) |
1 (1.00) |
0.0981 (1.00) |
0.933 (1.00) |
0.0822 (1.00) |
0.807 (1.00) |
Del Peak 7(4p13) | 0 (0%) | 104 |
0.78 (1.00) |
0.228 (1.00) |
0.000895 (0.639) |
0.024 (1.00) |
0.787 (1.00) |
0.313 (1.00) |
0.503 (1.00) |
0.293 (1.00) |
0.975 (1.00) |
0.0616 (1.00) |
0.626 (1.00) |
0.226 (1.00) |
Del Peak 9(4q35 1) | 0 (0%) | 90 |
0.609 (1.00) |
0.334 (1.00) |
0.000537 (0.386) |
0.0525 (1.00) |
0.506 (1.00) |
0.688 (1.00) |
0.452 (1.00) |
0.038 (1.00) |
0.431 (1.00) |
0.0369 (1.00) |
0.899 (1.00) |
0.349 (1.00) |
Del Peak 10(5q11 2) | 0 (0%) | 113 |
0.168 (1.00) |
0.0498 (1.00) |
0.102 (1.00) |
0.00391 (1.00) |
0.94 (1.00) |
0.24 (1.00) |
0.117 (1.00) |
0.93 (1.00) |
0.458 (1.00) |
0.0378 (1.00) |
0.142 (1.00) |
0.157 (1.00) |
Del Peak 11(5q22 2) | 0 (0%) | 107 |
0.313 (1.00) |
0.019 (1.00) |
0.0844 (1.00) |
0.397 (1.00) |
0.684 (1.00) |
0.987 (1.00) |
0.468 (1.00) |
0.675 (1.00) |
0.66 (1.00) |
0.191 (1.00) |
0.0623 (1.00) |
0.104 (1.00) |
Del Peak 12(6p25 3) | 0 (0%) | 138 |
1 (1.00) |
0.826 (1.00) |
0.648 (1.00) |
0.0338 (1.00) |
0.654 (1.00) |
0.988 (1.00) |
0.68 (1.00) |
0.554 (1.00) |
0.69 (1.00) |
0.568 (1.00) |
0.698 (1.00) |
0.476 (1.00) |
Del Peak 13(6q26) | 0 (0%) | 132 |
0.158 (1.00) |
0.0354 (1.00) |
0.159 (1.00) |
0.799 (1.00) |
0.0993 (1.00) |
0.343 (1.00) |
0.89 (1.00) |
0.648 (1.00) |
0.0771 (1.00) |
0.0645 (1.00) |
0.302 (1.00) |
0.566 (1.00) |
Del Peak 14(7q31 1) | 0 (0%) | 158 |
0.311 (1.00) |
1 (1.00) |
0.459 (1.00) |
0.749 (1.00) |
1 (1.00) |
|||||||
Del Peak 16(8p11 21) | 0 (0%) | 138 |
0.317 (1.00) |
0.69 (1.00) |
0.14 (1.00) |
0.324 (1.00) |
0.112 (1.00) |
0.56 (1.00) |
0.408 (1.00) |
0.423 (1.00) |
0.0753 (1.00) |
0.117 (1.00) |
0.17 (1.00) |
0.0408 (1.00) |
Del Peak 17(10q21 1) | 0 (0%) | 125 |
0.218 (1.00) |
0.228 (1.00) |
0.0716 (1.00) |
0.246 (1.00) |
0.0595 (1.00) |
0.0237 (1.00) |
0.183 (1.00) |
0.62 (1.00) |
0.747 (1.00) |
0.892 (1.00) |
0.864 (1.00) |
0.594 (1.00) |
Del Peak 18(10q25 2) | 0 (0%) | 115 |
0.57 (1.00) |
0.626 (1.00) |
0.806 (1.00) |
0.595 (1.00) |
0.455 (1.00) |
0.203 (1.00) |
0.129 (1.00) |
0.928 (1.00) |
0.703 (1.00) |
0.742 (1.00) |
0.983 (1.00) |
0.615 (1.00) |
Del Peak 19(11q22 3) | 0 (0%) | 125 |
0.00481 (1.00) |
0.0127 (1.00) |
0.0015 (1.00) |
0.09 (1.00) |
0.826 (1.00) |
0.0557 (1.00) |
0.0198 (1.00) |
0.000489 (0.352) |
0.444 (1.00) |
0.617 (1.00) |
0.725 (1.00) |
0.543 (1.00) |
Del Peak 20(12p13 1) | 0 (0%) | 129 |
1 (1.00) |
1 (1.00) |
0.657 (1.00) |
0.224 (1.00) |
0.535 (1.00) |
0.311 (1.00) |
0.391 (1.00) |
0.00666 (1.00) |
0.287 (1.00) |
0.224 (1.00) |
0.794 (1.00) |
0.155 (1.00) |
Del Peak 21(12q21 33) | 0 (0%) | 134 |
0.671 (1.00) |
0.92 (1.00) |
0.0206 (1.00) |
0.69 (1.00) |
0.606 (1.00) |
0.775 (1.00) |
0.383 (1.00) |
0.0422 (1.00) |
0.467 (1.00) |
0.247 (1.00) |
0.617 (1.00) |
0.368 (1.00) |
Del Peak 22(14q11 2) | 0 (0%) | 95 |
0.678 (1.00) |
0.666 (1.00) |
0.00346 (1.00) |
1 (1.00) |
0.803 (1.00) |
0.888 (1.00) |
0.395 (1.00) |
0.39 (1.00) |
0.0858 (1.00) |
0.141 (1.00) |
0.702 (1.00) |
0.632 (1.00) |
Del Peak 23(14q31 1) | 0 (0%) | 93 |
0.678 (1.00) |
0.666 (1.00) |
0.0115 (1.00) |
1 (1.00) |
0.633 (1.00) |
0.316 (1.00) |
0.261 (1.00) |
0.442 (1.00) |
0.161 (1.00) |
0.2 (1.00) |
0.853 (1.00) |
0.798 (1.00) |
Del Peak 25(16p13 3) | 0 (0%) | 149 |
0.886 (1.00) |
0.778 (1.00) |
0.535 (1.00) |
0.0269 (1.00) |
0.725 (1.00) |
0.667 (1.00) |
0.747 (1.00) |
1 (1.00) |
0.237 (1.00) |
0.317 (1.00) |
0.913 (1.00) |
0.693 (1.00) |
Del Peak 26(16q23 1) | 0 (0%) | 139 |
0.153 (1.00) |
0.191 (1.00) |
0.0873 (1.00) |
0.202 (1.00) |
0.589 (1.00) |
0.711 (1.00) |
0.44 (1.00) |
1 (1.00) |
0.619 (1.00) |
0.103 (1.00) |
0.613 (1.00) |
0.237 (1.00) |
Del Peak 27(17p12) | 0 (0%) | 52 |
0.165 (1.00) |
0.485 (1.00) |
0.0299 (1.00) |
0.555 (1.00) |
0.521 (1.00) |
0.756 (1.00) |
0.206 (1.00) |
0.0314 (1.00) |
0.87 (1.00) |
0.446 (1.00) |
0.479 (1.00) |
0.697 (1.00) |
Del Peak 28(17p11 2) | 0 (0%) | 60 |
0.331 (1.00) |
0.52 (1.00) |
0.0494 (1.00) |
0.797 (1.00) |
0.919 (1.00) |
0.379 (1.00) |
0.0582 (1.00) |
0.0696 (1.00) |
0.999 (1.00) |
0.915 (1.00) |
1 (1.00) |
0.767 (1.00) |
Del Peak 29(17q25 3) | 0 (0%) | 138 |
0.544 (1.00) |
0.236 (1.00) |
0.192 (1.00) |
0.0232 (1.00) |
0.457 (1.00) |
0.171 (1.00) |
0.0483 (1.00) |
0.015 (1.00) |
0.352 (1.00) |
0.155 (1.00) |
0.409 (1.00) |
0.175 (1.00) |
Del Peak 32(19p13 3) | 0 (0%) | 124 |
0.198 (1.00) |
0.491 (1.00) |
0.0671 (1.00) |
0.0528 (1.00) |
0.893 (1.00) |
0.958 (1.00) |
0.409 (1.00) |
0.0191 (1.00) |
0.492 (1.00) |
0.0125 (1.00) |
0.323 (1.00) |
0.215 (1.00) |
Del Peak 33(20p12 1) | 0 (0%) | 102 |
0.621 (1.00) |
0.782 (1.00) |
0.0361 (1.00) |
0.724 (1.00) |
0.54 (1.00) |
0.28 (1.00) |
0.233 (1.00) |
0.93 (1.00) |
0.0474 (1.00) |
0.234 (1.00) |
0.777 (1.00) |
0.957 (1.00) |
Del Peak 34(20p12 1) | 0 (0%) | 102 |
0.621 (1.00) |
0.782 (1.00) |
0.0361 (1.00) |
0.724 (1.00) |
0.54 (1.00) |
0.28 (1.00) |
0.233 (1.00) |
0.93 (1.00) |
0.0474 (1.00) |
0.234 (1.00) |
0.777 (1.00) |
0.957 (1.00) |
Del Peak 35(21q11 2) | 0 (0%) | 92 |
0.486 (1.00) |
0.12 (1.00) |
0.304 (1.00) |
0.964 (1.00) |
0.924 (1.00) |
0.41 (1.00) |
0.55 (1.00) |
0.937 (1.00) |
0.052 (1.00) |
0.465 (1.00) |
0.348 (1.00) |
0.53 (1.00) |
Del Peak 36(22q13 31) | 0 (0%) | 96 |
0.952 (1.00) |
0.513 (1.00) |
0.222 (1.00) |
0.695 (1.00) |
0.532 (1.00) |
0.462 (1.00) |
0.264 (1.00) |
0.194 (1.00) |
0.00619 (1.00) |
0.337 (1.00) |
0.198 (1.00) |
0.183 (1.00) |
Del Peak 37(Xp22 33) | 0 (0%) | 129 |
0.778 (1.00) |
0.775 (1.00) |
0.266 (1.00) |
0.00204 (1.00) |
0.724 (1.00) |
0.801 (1.00) |
0.91 (1.00) |
1 (1.00) |
0.643 (1.00) |
0.819 (1.00) |
0.977 (1.00) |
0.699 (1.00) |
P value = 0.000112 (Chi-square test), Q value = 0.081
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
AMP PEAK 4(6P21.1) CNV | 4 | 16 | 11 | 8 | 13 |
AMP PEAK 4(6P21.1) WILD-TYPE | 3 | 16 | 35 | 47 | 9 |
P value = 2.54e-08 (Chi-square test), Q value = 1.9e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
AMP PEAK 5(8P11.23) CNV | 2 | 12 | 29 | 2 | 7 |
AMP PEAK 5(8P11.23) WILD-TYPE | 5 | 20 | 17 | 53 | 15 |
P value = 2.38e-13 (Chi-square test), Q value = 1.7e-10
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
AMP PEAK 6(8P11.21) CNV | 3 | 13 | 40 | 4 | 9 |
AMP PEAK 6(8P11.21) WILD-TYPE | 4 | 19 | 6 | 51 | 13 |
P value = 1.7e-09 (Chi-square test), Q value = 1.2e-06
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
AMP PEAK 7(8Q24.21) CNV | 4 | 25 | 46 | 22 | 10 |
AMP PEAK 7(8Q24.21) WILD-TYPE | 3 | 7 | 0 | 33 | 12 |
P value = 3.06e-05 (Chi-square test), Q value = 0.022
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
AMP PEAK 13(13Q12.13) CNV | 6 | 30 | 33 | 30 | 22 |
AMP PEAK 13(13Q12.13) WILD-TYPE | 1 | 2 | 13 | 25 | 0 |
P value = 4.86e-06 (Chi-square test), Q value = 0.0036
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
AMP PEAK 14(13Q12.2) CNV | 6 | 30 | 34 | 28 | 22 |
AMP PEAK 14(13Q12.2) WILD-TYPE | 1 | 2 | 12 | 27 | 0 |
P value = 1.02e-07 (Chi-square test), Q value = 7.5e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
AMP PEAK 15(13Q22.1) CNV | 7 | 30 | 33 | 25 | 22 |
AMP PEAK 15(13Q22.1) WILD-TYPE | 0 | 2 | 13 | 30 | 0 |
P value = 2.96e-05 (Chi-square test), Q value = 0.021
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
AMP PEAK 17(16P11.2) CNV | 2 | 16 | 10 | 5 | 12 |
AMP PEAK 17(16P11.2) WILD-TYPE | 5 | 16 | 36 | 50 | 10 |
P value = 2e-04 (Chi-square test), Q value = 0.14
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
AMP PEAK 18(17Q12) CNV | 2 | 17 | 15 | 8 | 1 |
AMP PEAK 18(17Q12) WILD-TYPE | 5 | 15 | 31 | 47 | 21 |
P value = 0.000331 (Chi-square test), Q value = 0.24
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
AMP PEAK 19(17Q24.1) CNV | 1 | 16 | 10 | 10 | 0 |
AMP PEAK 19(17Q24.1) WILD-TYPE | 6 | 16 | 36 | 45 | 22 |
P value = 0.000178 (Chi-square test), Q value = 0.13
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
DEL PEAK 3(1P13.2) CNV | 6 | 15 | 16 | 7 | 7 |
DEL PEAK 3(1P13.2) WILD-TYPE | 1 | 17 | 30 | 48 | 15 |
P value = 9.65e-05 (Chi-square test), Q value = 0.07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
DEL PEAK 8(4Q22.1) CNV | 6 | 18 | 19 | 13 | 16 |
DEL PEAK 8(4Q22.1) WILD-TYPE | 1 | 14 | 27 | 42 | 6 |
P value = 6.4e-06 (Chi-square test), Q value = 0.0047
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
DEL PEAK 15(8P23.2) CNV | 6 | 25 | 37 | 19 | 13 |
DEL PEAK 15(8P23.2) WILD-TYPE | 1 | 7 | 9 | 36 | 9 |
P value = 0.000218 (Chi-square test), Q value = 0.16
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
DEL PEAK 24(15Q22.33) CNV | 6 | 20 | 22 | 13 | 14 |
DEL PEAK 24(15Q22.33) WILD-TYPE | 1 | 12 | 24 | 42 | 8 |
P value = 5.18e-06 (Chi-square test), Q value = 0.0038
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
DEL PEAK 30(18Q21.2) CNV | 7 | 32 | 45 | 38 | 21 |
DEL PEAK 30(18Q21.2) WILD-TYPE | 0 | 0 | 1 | 17 | 1 |
P value = 2.38e-07 (Chi-square test), Q value = 0.00017
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 7 | 32 | 46 | 55 | 22 |
DEL PEAK 31(18Q22.1) CNV | 7 | 32 | 44 | 34 | 21 |
DEL PEAK 31(18Q22.1) WILD-TYPE | 0 | 0 | 2 | 21 | 1 |
-
Copy number data file = All Lesions File (all_lesions.conf_##.txt, where ## is the confidence level). The all lesions file is from GISTIC pipeline and summarizes the results from the GISTIC run. It contains data about the significant regions of amplification and deletion as well as which samples are amplified or deleted in each of these regions. The identified regions are listed down the first column, and the samples are listed across the first row, starting in column 10.
-
Molecular subtype file = READ-TP.transferedmergedcluster.txt
-
Number of patients = 162
-
Number of copy number variation regions = 62
-
Number of molecular subtypes = 12
-
Exclude regions that fewer than K tumors have alterations, K = 3
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.