This pipeline computes the correlation between significant copy number variation (cnv focal) genes and selected clinical features.
Testing the association between copy number variation 55 focal events and 14 clinical features across 205 patients, 20 significant findings detected with Q value < 0.25.
-
amp_5q35.3 cnv correlated to 'PSA_VALUE'.
-
amp_8q24.21 cnv correlated to 'GLEASON_SCORE_COMBINED', 'GLEASON_SCORE_PRIMARY', and 'GLEASON_SCORE'.
-
amp_9q34.3 cnv correlated to 'GLEASON_SCORE_PRIMARY'.
-
amp_20q13.31 cnv correlated to 'PATHOLOGY.T.STAGE' and 'GLEASON_SCORE_PRIMARY'.
-
amp_xp22.11 cnv correlated to 'PSA_VALUE' and 'DAYS_TO_PSA'.
-
amp_xp22.11 cnv correlated to 'PSA_VALUE'.
-
amp_xp21.1 cnv correlated to 'PSA_VALUE'.
-
amp_xq21.1 cnv correlated to 'PSA_VALUE'.
-
amp_xq21.1 cnv correlated to 'PSA_VALUE'.
-
amp_xq21.31 cnv correlated to 'GLEASON_SCORE_PRIMARY'.
-
amp_xq25 cnv correlated to 'AGE'.
-
amp_xq25 cnv correlated to 'PSA_VALUE'.
-
del_1q23.1 cnv correlated to 'DAYS_TO_PSA'.
-
del_4q28.2 cnv correlated to 'PSA_VALUE'.
-
del_6q14.3 cnv correlated to 'GLEASON_SCORE_PRIMARY'.
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del_8p21.3 cnv correlated to 'GLEASON_SCORE_PRIMARY'.
Clinical Features |
Time to Death |
AGE |
PATHOLOGY T STAGE |
PATHOLOGY N STAGE |
COMPLETENESS OF RESECTION |
NUMBER OF LYMPH NODES |
GLEASON SCORE COMBINED |
GLEASON SCORE PRIMARY |
GLEASON SCORE SECONDARY |
GLEASON SCORE |
PSA RESULT PREOP |
DAYS TO PREOP PSA |
PSA VALUE |
DAYS TO PSA |
||
nCNV (%) | nWild-Type | logrank test | t-test | Fisher's exact test | Fisher's exact test | Fisher's exact test | t-test | t-test | t-test | t-test | t-test | t-test | t-test | t-test | t-test | |
amp 8q24 21 | 51 (25%) | 154 |
100 (1.00) |
0.136 (1.00) |
0.0194 (1.00) |
0.0818 (1.00) |
0.935 (1.00) |
0.251 (1.00) |
1.98e-05 (0.0151) |
6.97e-06 (0.00534) |
0.122 (1.00) |
6.67e-05 (0.0509) |
0.0386 (1.00) |
0.416 (1.00) |
0.357 (1.00) |
0.651 (1.00) |
amp 20q13 31 | 11 (5%) | 194 |
100 (1.00) |
0.0139 (1.00) |
0.000192 (0.146) |
0.604 (1.00) |
0.429 (1.00) |
0.000789 (0.582) |
0.0656 (1.00) |
9.53e-06 (0.00729) |
0.871 (1.00) |
0.0316 (1.00) |
0.194 (1.00) |
0.895 (1.00) |
0.66 (1.00) |
0.177 (1.00) |
amp xp22 11 | 8 (4%) | 197 |
100 (1.00) |
0.962 (1.00) |
0.42 (1.00) |
0.573 (1.00) |
1 (1.00) |
0.771 (1.00) |
0.342 (1.00) |
0.276 (1.00) |
0.902 (1.00) |
0.434 (1.00) |
0.393 (1.00) |
0.725 (1.00) |
0.00022 (0.166) |
0.000253 (0.191) |
amp 5q35 3 | 7 (3%) | 198 |
100 (1.00) |
0.00111 (0.811) |
0.0145 (1.00) |
0.524 (1.00) |
0.691 (1.00) |
0.824 (1.00) |
0.289 (1.00) |
0.214 (1.00) |
0.803 (1.00) |
0.0531 (1.00) |
0.673 (1.00) |
0.495 (1.00) |
0.000327 (0.245) |
0.62 (1.00) |
amp 9q34 3 | 20 (10%) | 185 |
100 (1.00) |
0.321 (1.00) |
0.00846 (1.00) |
0.000429 (0.32) |
0.729 (1.00) |
0.0557 (1.00) |
0.000433 (0.323) |
0.000158 (0.12) |
0.0915 (1.00) |
0.000439 (0.327) |
0.0649 (1.00) |
0.241 (1.00) |
0.181 (1.00) |
0.861 (1.00) |
amp xp22 11 | 8 (4%) | 197 |
100 (1.00) |
0.308 (1.00) |
0.42 (1.00) |
0.573 (1.00) |
1 (1.00) |
0.771 (1.00) |
0.342 (1.00) |
0.103 (1.00) |
0.444 (1.00) |
0.779 (1.00) |
0.289 (1.00) |
0.437 (1.00) |
0.000214 (0.162) |
0.0679 (1.00) |
amp xp21 1 | 7 (3%) | 198 |
100 (1.00) |
0.223 (1.00) |
0.267 (1.00) |
0.524 (1.00) |
1 (1.00) |
0.824 (1.00) |
0.529 (1.00) |
0.401 (1.00) |
0.767 (1.00) |
0.359 (1.00) |
0.453 (1.00) |
0.717 (1.00) |
0.000267 (0.201) |
0.172 (1.00) |
amp xq21 1 | 7 (3%) | 198 |
100 (1.00) |
0.669 (1.00) |
0.542 (1.00) |
0.524 (1.00) |
0.458 (1.00) |
0.708 (1.00) |
0.529 (1.00) |
0.606 (1.00) |
0.746 (1.00) |
0.453 (1.00) |
0.987 (1.00) |
0.373 (1.00) |
0.000204 (0.154) |
0.658 (1.00) |
amp xq21 1 | 5 (2%) | 200 |
100 (1.00) |
0.307 (1.00) |
0.449 (1.00) |
0.0772 (1.00) |
0.636 (1.00) |
0.333 (1.00) |
0.404 (1.00) |
0.601 (1.00) |
0.501 (1.00) |
0.465 (1.00) |
0.408 (1.00) |
0.178 (1.00) |
0.000283 (0.213) |
0.436 (1.00) |
amp xq21 31 | 5 (2%) | 200 |
100 (1.00) |
0.219 (1.00) |
1 (1.00) |
1 (1.00) |
0.636 (1.00) |
0.000794 (0.583) |
0.303 (1.00) |
4.35e-30 (3.34e-27) |
0.954 (1.00) |
0.618 (1.00) |
0.461 (1.00) |
0.359 (1.00) |
0.545 (1.00) |
0.782 (1.00) |
amp xq25 | 3 (1%) | 202 |
100 (1.00) |
1.62e-08 (1.24e-05) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.000796 (0.583) |
0.578 (1.00) |
0.6 (1.00) |
0.726 (1.00) |
0.619 (1.00) |
0.708 (1.00) |
0.437 (1.00) |
||
amp xq25 | 6 (3%) | 199 |
100 (1.00) |
0.77 (1.00) |
0.731 (1.00) |
0.47 (1.00) |
0.66 (1.00) |
0.956 (1.00) |
0.341 (1.00) |
0.874 (1.00) |
0.244 (1.00) |
0.545 (1.00) |
0.843 (1.00) |
0.533 (1.00) |
0.000205 (0.155) |
0.521 (1.00) |
del 1q23 1 | 9 (4%) | 196 |
100 (1.00) |
0.706 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.000792 (0.583) |
0.538 (1.00) |
0.247 (1.00) |
0.98 (1.00) |
0.88 (1.00) |
0.218 (1.00) |
0.0721 (1.00) |
0.0732 (1.00) |
0.000303 (0.227) |
del 4q28 2 | 17 (8%) | 188 |
100 (1.00) |
0.0325 (1.00) |
0.0588 (1.00) |
0.646 (1.00) |
0.561 (1.00) |
0.661 (1.00) |
0.188 (1.00) |
0.0911 (1.00) |
0.755 (1.00) |
0.127 (1.00) |
0.849 (1.00) |
0.193 (1.00) |
0.000183 (0.139) |
0.653 (1.00) |
del 6q14 3 | 64 (31%) | 141 |
100 (1.00) |
0.0433 (1.00) |
0.497 (1.00) |
0.00667 (1.00) |
0.0241 (1.00) |
0.0145 (1.00) |
0.000816 (0.596) |
0.000257 (0.194) |
0.386 (1.00) |
0.000998 (0.728) |
0.00512 (1.00) |
0.277 (1.00) |
0.0781 (1.00) |
0.782 (1.00) |
del 8p21 3 | 115 (56%) | 90 |
100 (1.00) |
0.372 (1.00) |
0.000452 (0.336) |
0.0661 (1.00) |
0.704 (1.00) |
0.0127 (1.00) |
0.138 (1.00) |
0.000196 (0.149) |
0.118 (1.00) |
0.253 (1.00) |
0.00153 (1.00) |
0.211 (1.00) |
0.632 (1.00) |
0.359 (1.00) |
amp 1q21 3 | 13 (6%) | 192 |
100 (1.00) |
0.511 (1.00) |
0.158 (1.00) |
0.337 (1.00) |
0.612 (1.00) |
0.531 (1.00) |
0.0235 (1.00) |
0.0226 (1.00) |
0.308 (1.00) |
0.0347 (1.00) |
0.186 (1.00) |
0.554 (1.00) |
0.591 (1.00) |
0.921 (1.00) |
amp 3q22 1 | 25 (12%) | 180 |
100 (1.00) |
0.0314 (1.00) |
0.0033 (1.00) |
0.705 (1.00) |
0.1 (1.00) |
0.466 (1.00) |
0.101 (1.00) |
0.00834 (1.00) |
0.71 (1.00) |
0.00631 (1.00) |
0.0573 (1.00) |
0.219 (1.00) |
0.0168 (1.00) |
0.18 (1.00) |
amp 3q26 2 | 33 (16%) | 172 |
100 (1.00) |
0.0682 (1.00) |
0.0241 (1.00) |
0.503 (1.00) |
1 (1.00) |
0.315 (1.00) |
0.168 (1.00) |
0.0236 (1.00) |
0.683 (1.00) |
0.0263 (1.00) |
0.0441 (1.00) |
0.658 (1.00) |
0.617 (1.00) |
0.991 (1.00) |
amp 4p16 3 | 10 (5%) | 195 |
100 (1.00) |
0.396 (1.00) |
0.0279 (1.00) |
1 (1.00) |
0.126 (1.00) |
0.487 (1.00) |
0.0248 (1.00) |
0.0319 (1.00) |
0.176 (1.00) |
0.0235 (1.00) |
0.622 (1.00) |
0.306 (1.00) |
0.0591 (1.00) |
0.676 (1.00) |
amp 4q13 3 | 4 (2%) | 201 |
100 (1.00) |
0.0788 (1.00) |
0.0956 (1.00) |
0.343 (1.00) |
0.261 (1.00) |
0.786 (1.00) |
0.139 (1.00) |
0.273 (1.00) |
0.0805 (1.00) |
0.15 (1.00) |
0.292 (1.00) |
0.499 (1.00) |
0.79 (1.00) |
0.696 (1.00) |
amp 7p15 3 | 39 (19%) | 166 |
100 (1.00) |
0.315 (1.00) |
0.015 (1.00) |
0.32 (1.00) |
0.0264 (1.00) |
0.26 (1.00) |
0.0278 (1.00) |
0.0499 (1.00) |
0.23 (1.00) |
0.0239 (1.00) |
0.0244 (1.00) |
0.365 (1.00) |
0.459 (1.00) |
0.165 (1.00) |
amp 8p11 23 | 18 (9%) | 187 |
100 (1.00) |
0.132 (1.00) |
0.288 (1.00) |
0.172 (1.00) |
0.705 (1.00) |
0.347 (1.00) |
0.0125 (1.00) |
0.0104 (1.00) |
0.23 (1.00) |
0.0104 (1.00) |
0.0469 (1.00) |
0.454 (1.00) |
0.137 (1.00) |
0.19 (1.00) |
amp 11q13 3 | 11 (5%) | 194 |
100 (1.00) |
0.296 (1.00) |
0.0154 (1.00) |
0.0625 (1.00) |
1 (1.00) |
0.293 (1.00) |
0.0476 (1.00) |
0.00183 (1.00) |
0.855 (1.00) |
0.0325 (1.00) |
0.372 (1.00) |
0.101 (1.00) |
0.0737 (1.00) |
0.768 (1.00) |
amp 12q24 32 | 7 (3%) | 198 |
100 (1.00) |
0.943 (1.00) |
0.158 (1.00) |
0.144 (1.00) |
0.289 (1.00) |
0.376 (1.00) |
0.0868 (1.00) |
0.0244 (1.00) |
0.746 (1.00) |
0.0324 (1.00) |
0.272 (1.00) |
0.126 (1.00) |
0.977 (1.00) |
0.2 (1.00) |
amp 14q21 1 | 10 (5%) | 195 |
100 (1.00) |
0.000393 (0.294) |
0.256 (1.00) |
0.573 (1.00) |
1 (1.00) |
0.7 (1.00) |
0.0424 (1.00) |
0.193 (1.00) |
0.29 (1.00) |
0.00496 (1.00) |
0.449 (1.00) |
0.692 (1.00) |
0.851 (1.00) |
0.115 (1.00) |
amp 15q11 2 | 6 (3%) | 199 |
100 (1.00) |
0.241 (1.00) |
0.501 (1.00) |
1 (1.00) |
0.66 (1.00) |
0.000794 (0.583) |
0.706 (1.00) |
0.371 (1.00) |
0.272 (1.00) |
0.545 (1.00) |
0.00942 (1.00) |
0.549 (1.00) |
0.000568 (0.421) |
0.354 (1.00) |
amp 19q13 43 | 5 (2%) | 200 |
100 (1.00) |
0.273 (1.00) |
0.0189 (1.00) |
1 (1.00) |
1 (1.00) |
0.000794 (0.583) |
0.154 (1.00) |
0.161 (1.00) |
0.306 (1.00) |
0.0451 (1.00) |
0.313 (1.00) |
0.758 (1.00) |
0.637 (1.00) |
0.32 (1.00) |
amp xq27 1 | 9 (4%) | 196 |
100 (1.00) |
0.279 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.000792 (0.583) |
0.958 (1.00) |
0.606 (1.00) |
0.661 (1.00) |
0.788 (1.00) |
0.0793 (1.00) |
0.128 (1.00) |
0.000687 (0.508) |
0.157 (1.00) |
del 1p31 3 | 27 (13%) | 178 |
100 (1.00) |
0.554 (1.00) |
0.115 (1.00) |
0.71 (1.00) |
0.101 (1.00) |
0.8 (1.00) |
0.0106 (1.00) |
0.0976 (1.00) |
0.0272 (1.00) |
0.021 (1.00) |
0.628 (1.00) |
0.627 (1.00) |
0.766 (1.00) |
0.211 (1.00) |
del 1q42 2 | 16 (8%) | 189 |
100 (1.00) |
0.215 (1.00) |
0.3 (1.00) |
0.199 (1.00) |
0.28 (1.00) |
0.474 (1.00) |
0.604 (1.00) |
0.289 (1.00) |
0.489 (1.00) |
0.169 (1.00) |
0.364 (1.00) |
0.627 (1.00) |
0.443 (1.00) |
0.833 (1.00) |
del 2p22 1 | 12 (6%) | 193 |
100 (1.00) |
0.997 (1.00) |
0.134 (1.00) |
0.02 (1.00) |
0.557 (1.00) |
0.216 (1.00) |
0.0304 (1.00) |
0.0404 (1.00) |
0.112 (1.00) |
0.0404 (1.00) |
0.936 (1.00) |
0.532 (1.00) |
0.618 (1.00) |
0.191 (1.00) |
del 2q22 1 | 27 (13%) | 178 |
100 (1.00) |
0.00559 (1.00) |
0.589 (1.00) |
1 (1.00) |
0.489 (1.00) |
0.604 (1.00) |
0.109 (1.00) |
0.00125 (0.91) |
0.424 (1.00) |
0.047 (1.00) |
0.813 (1.00) |
0.0483 (1.00) |
0.0439 (1.00) |
0.498 (1.00) |
del 2q22 3 | 23 (11%) | 182 |
100 (1.00) |
0.0826 (1.00) |
0.596 (1.00) |
1 (1.00) |
0.67 (1.00) |
0.445 (1.00) |
0.489 (1.00) |
0.105 (1.00) |
0.586 (1.00) |
0.0844 (1.00) |
0.861 (1.00) |
0.605 (1.00) |
0.0697 (1.00) |
0.162 (1.00) |
del 3p13 | 32 (16%) | 173 |
100 (1.00) |
0.157 (1.00) |
0.492 (1.00) |
1 (1.00) |
0.164 (1.00) |
0.751 (1.00) |
0.726 (1.00) |
0.779 (1.00) |
0.838 (1.00) |
0.648 (1.00) |
0.657 (1.00) |
0.793 (1.00) |
0.409 (1.00) |
0.88 (1.00) |
del 3q29 | 11 (5%) | 194 |
100 (1.00) |
0.274 (1.00) |
0.66 (1.00) |
1 (1.00) |
1 (1.00) |
0.976 (1.00) |
0.906 (1.00) |
0.971 (1.00) |
0.794 (1.00) |
0.792 (1.00) |
0.687 (1.00) |
0.817 (1.00) |
0.000371 (0.278) |
0.992 (1.00) |
del 5q11 2 | 28 (14%) | 177 |
100 (1.00) |
0.161 (1.00) |
0.000724 (0.534) |
0.000674 (0.499) |
1 (1.00) |
0.0484 (1.00) |
0.0026 (1.00) |
0.00374 (1.00) |
0.115 (1.00) |
0.00297 (1.00) |
0.0208 (1.00) |
0.983 (1.00) |
0.456 (1.00) |
0.196 (1.00) |
del 5q21 1 | 36 (18%) | 169 |
100 (1.00) |
0.0235 (1.00) |
0.881 (1.00) |
0.101 (1.00) |
1 (1.00) |
0.25 (1.00) |
0.0725 (1.00) |
0.00253 (1.00) |
0.641 (1.00) |
0.0415 (1.00) |
0.649 (1.00) |
0.899 (1.00) |
0.396 (1.00) |
0.652 (1.00) |
del 8p11 21 | 66 (32%) | 139 |
100 (1.00) |
0.112 (1.00) |
0.143 (1.00) |
1 (1.00) |
0.0114 (1.00) |
0.735 (1.00) |
0.771 (1.00) |
0.165 (1.00) |
0.0889 (1.00) |
0.489 (1.00) |
0.351 (1.00) |
0.114 (1.00) |
0.135 (1.00) |
0.132 (1.00) |
del 9p23 | 18 (9%) | 187 |
100 (1.00) |
0.782 (1.00) |
0.288 (1.00) |
0.0152 (1.00) |
0.705 (1.00) |
0.152 (1.00) |
0.0327 (1.00) |
0.0145 (1.00) |
0.49 (1.00) |
0.079 (1.00) |
0.19 (1.00) |
0.281 (1.00) |
0.901 (1.00) |
0.777 (1.00) |
del 10q23 31 | 67 (33%) | 138 |
100 (1.00) |
0.894 (1.00) |
0.0192 (1.00) |
0.00286 (1.00) |
0.757 (1.00) |
0.149 (1.00) |
0.0647 (1.00) |
0.205 (1.00) |
0.211 (1.00) |
0.0184 (1.00) |
0.956 (1.00) |
0.547 (1.00) |
0.155 (1.00) |
0.285 (1.00) |
del 11q23 2 | 18 (9%) | 187 |
100 (1.00) |
0.487 (1.00) |
0.00867 (1.00) |
1 (1.00) |
0.561 (1.00) |
0.142 (1.00) |
0.317 (1.00) |
0.244 (1.00) |
0.962 (1.00) |
0.226 (1.00) |
0.244 (1.00) |
0.709 (1.00) |
0.314 (1.00) |
0.951 (1.00) |
del 12p13 1 | 43 (21%) | 162 |
100 (1.00) |
0.951 (1.00) |
0.131 (1.00) |
0.129 (1.00) |
0.54 (1.00) |
0.441 (1.00) |
0.0777 (1.00) |
0.0112 (1.00) |
0.971 (1.00) |
0.0604 (1.00) |
0.83 (1.00) |
0.279 (1.00) |
0.968 (1.00) |
0.568 (1.00) |
del 12q24 31 | 18 (9%) | 187 |
100 (1.00) |
0.767 (1.00) |
0.451 (1.00) |
0.382 (1.00) |
1 (1.00) |
1 (1.00) |
0.108 (1.00) |
0.291 (1.00) |
0.294 (1.00) |
0.138 (1.00) |
0.179 (1.00) |
0.391 (1.00) |
0.0231 (1.00) |
0.829 (1.00) |
del 13q14 12 | 88 (43%) | 117 |
100 (1.00) |
0.0308 (1.00) |
0.575 (1.00) |
0.305 (1.00) |
0.312 (1.00) |
0.24 (1.00) |
0.0891 (1.00) |
0.199 (1.00) |
0.341 (1.00) |
0.0231 (1.00) |
0.0739 (1.00) |
0.539 (1.00) |
0.676 (1.00) |
0.381 (1.00) |
del 13q22 1 | 72 (35%) | 133 |
100 (1.00) |
0.0267 (1.00) |
0.128 (1.00) |
0.0655 (1.00) |
0.804 (1.00) |
0.121 (1.00) |
0.0432 (1.00) |
0.154 (1.00) |
0.2 (1.00) |
0.00424 (1.00) |
0.0188 (1.00) |
0.182 (1.00) |
0.983 (1.00) |
0.406 (1.00) |
del 15q21 3 | 20 (10%) | 185 |
100 (1.00) |
0.696 (1.00) |
0.0999 (1.00) |
0.0152 (1.00) |
0.627 (1.00) |
0.112 (1.00) |
0.00327 (1.00) |
0.000678 (0.502) |
0.399 (1.00) |
0.0041 (1.00) |
0.351 (1.00) |
0.342 (1.00) |
0.921 (1.00) |
0.383 (1.00) |
del 16q22 3 | 71 (35%) | 134 |
100 (1.00) |
0.19 (1.00) |
0.0225 (1.00) |
0.185 (1.00) |
1 (1.00) |
0.123 (1.00) |
0.00467 (1.00) |
0.00129 (0.939) |
0.458 (1.00) |
0.00475 (1.00) |
0.0849 (1.00) |
0.563 (1.00) |
0.0578 (1.00) |
0.352 (1.00) |
del 16q23 3 | 81 (40%) | 124 |
100 (1.00) |
0.284 (1.00) |
0.0361 (1.00) |
0.44 (1.00) |
0.949 (1.00) |
0.2 (1.00) |
0.0019 (1.00) |
0.00269 (1.00) |
0.212 (1.00) |
0.00257 (1.00) |
0.142 (1.00) |
0.776 (1.00) |
0.0407 (1.00) |
0.38 (1.00) |
del 17p13 1 | 52 (25%) | 153 |
100 (1.00) |
0.752 (1.00) |
0.0123 (1.00) |
0.00336 (1.00) |
0.521 (1.00) |
0.0671 (1.00) |
0.00258 (1.00) |
0.00453 (1.00) |
0.15 (1.00) |
0.00244 (1.00) |
0.115 (1.00) |
0.707 (1.00) |
0.102 (1.00) |
0.65 (1.00) |
del 17q21 31 | 39 (19%) | 166 |
100 (1.00) |
0.955 (1.00) |
0.561 (1.00) |
0.748 (1.00) |
0.167 (1.00) |
0.706 (1.00) |
0.587 (1.00) |
0.587 (1.00) |
0.796 (1.00) |
0.588 (1.00) |
0.147 (1.00) |
0.95 (1.00) |
0.963 (1.00) |
0.89 (1.00) |
del 18q22 1 | 51 (25%) | 154 |
100 (1.00) |
0.534 (1.00) |
0.341 (1.00) |
0.375 (1.00) |
0.22 (1.00) |
0.489 (1.00) |
0.0144 (1.00) |
0.111 (1.00) |
0.0485 (1.00) |
0.0114 (1.00) |
0.458 (1.00) |
0.682 (1.00) |
0.412 (1.00) |
0.96 (1.00) |
del 19q13 2 | 17 (8%) | 188 |
100 (1.00) |
0.138 (1.00) |
0.193 (1.00) |
0.0694 (1.00) |
0.233 (1.00) |
0.335 (1.00) |
0.0634 (1.00) |
0.0439 (1.00) |
0.495 (1.00) |
0.0558 (1.00) |
0.303 (1.00) |
0.714 (1.00) |
0.605 (1.00) |
0.414 (1.00) |
del 21q22 2 | 21 (10%) | 184 |
100 (1.00) |
0.181 (1.00) |
0.0567 (1.00) |
0.00241 (1.00) |
0.639 (1.00) |
0.0611 (1.00) |
0.672 (1.00) |
0.927 (1.00) |
0.526 (1.00) |
0.83 (1.00) |
0.283 (1.00) |
0.247 (1.00) |
0.271 (1.00) |
0.932 (1.00) |
del 21q22 3 | 58 (28%) | 147 |
100 (1.00) |
1 (1.00) |
0.0165 (1.00) |
0.00175 (1.00) |
0.291 (1.00) |
0.0461 (1.00) |
0.256 (1.00) |
0.427 (1.00) |
0.411 (1.00) |
0.422 (1.00) |
0.226 (1.00) |
0.0322 (1.00) |
0.274 (1.00) |
0.549 (1.00) |
P value = 0.000327 (t-test), Q value = 0.24
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 176 | 1.3 (4.3) |
AMP PEAK 6(5Q35.3) MUTATED | 6 | 0.1 (0.1) |
AMP PEAK 6(5Q35.3) WILD-TYPE | 170 | 1.4 (4.4) |
P value = 1.98e-05 (t-test), Q value = 0.015
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 205 | 7.2 (0.8) |
AMP PEAK 9(8Q24.21) MUTATED | 51 | 7.7 (0.9) |
AMP PEAK 9(8Q24.21) WILD-TYPE | 154 | 7.1 (0.7) |
P value = 6.97e-06 (t-test), Q value = 0.0053
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 205 | 3.5 (0.6) |
AMP PEAK 9(8Q24.21) MUTATED | 51 | 3.8 (0.6) |
AMP PEAK 9(8Q24.21) WILD-TYPE | 154 | 3.4 (0.5) |
P value = 6.67e-05 (t-test), Q value = 0.051
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 205 | 7.3 (0.8) |
AMP PEAK 9(8Q24.21) MUTATED | 51 | 7.7 (1.0) |
AMP PEAK 9(8Q24.21) WILD-TYPE | 154 | 7.1 (0.7) |
P value = 0.000158 (t-test), Q value = 0.12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 205 | 3.5 (0.6) |
AMP PEAK 10(9Q34.3) MUTATED | 20 | 4.0 (0.6) |
AMP PEAK 10(9Q34.3) WILD-TYPE | 185 | 3.4 (0.5) |
P value = 0.000192 (Fisher's exact test), Q value = 0.15
nPatients | T2 | T3 | T4 |
---|---|---|---|
ALL | 92 | 106 | 5 |
AMP PEAK 16(20Q13.31) MUTATED | 0 | 9 | 2 |
AMP PEAK 16(20Q13.31) WILD-TYPE | 92 | 97 | 3 |
P value = 9.53e-06 (t-test), Q value = 0.0073
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 205 | 3.5 (0.6) |
AMP PEAK 16(20Q13.31) MUTATED | 11 | 4.1 (0.3) |
AMP PEAK 16(20Q13.31) WILD-TYPE | 194 | 3.4 (0.6) |
P value = 0.00022 (t-test), Q value = 0.17
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 176 | 1.3 (4.3) |
AMP PEAK 17(XP22.11) MUTATED | 5 | 0.1 (0.1) |
AMP PEAK 17(XP22.11) WILD-TYPE | 171 | 1.4 (4.4) |
P value = 0.000253 (t-test), Q value = 0.19
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 181 | 577.6 (545.5) |
AMP PEAK 17(XP22.11) MUTATED | 5 | 191.4 (125.9) |
AMP PEAK 17(XP22.11) WILD-TYPE | 176 | 588.6 (548.9) |
P value = 0.000214 (t-test), Q value = 0.16
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 176 | 1.3 (4.3) |
AMP PEAK 18(XP22.11) MUTATED | 6 | 0.1 (0.1) |
AMP PEAK 18(XP22.11) WILD-TYPE | 170 | 1.4 (4.4) |
P value = 0.000267 (t-test), Q value = 0.2
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 176 | 1.3 (4.3) |
AMP PEAK 19(XP21.1) MUTATED | 5 | 0.1 (0.0) |
AMP PEAK 19(XP21.1) WILD-TYPE | 171 | 1.4 (4.4) |
P value = 0.000204 (t-test), Q value = 0.15
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 176 | 1.3 (4.3) |
AMP PEAK 20(XQ21.1) MUTATED | 6 | 0.1 (0.0) |
AMP PEAK 20(XQ21.1) WILD-TYPE | 170 | 1.4 (4.4) |
P value = 0.000283 (t-test), Q value = 0.21
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 176 | 1.3 (4.3) |
AMP PEAK 21(XQ21.1) MUTATED | 4 | 0.1 (0.0) |
AMP PEAK 21(XQ21.1) WILD-TYPE | 172 | 1.4 (4.4) |
P value = 4.35e-30 (t-test), Q value = 3.3e-27
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 205 | 3.5 (0.6) |
AMP PEAK 22(XQ21.31) MUTATED | 5 | 4.0 (0.0) |
AMP PEAK 22(XQ21.31) WILD-TYPE | 200 | 3.5 (0.6) |
P value = 1.62e-08 (t-test), Q value = 1.2e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 203 | 60.2 (6.9) |
AMP PEAK 23(XQ25) MUTATED | 3 | 65.7 (0.6) |
AMP PEAK 23(XQ25) WILD-TYPE | 200 | 60.2 (6.9) |
P value = 0.000205 (t-test), Q value = 0.16
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 176 | 1.3 (4.3) |
AMP PEAK 24(XQ25) MUTATED | 5 | 0.1 (0.0) |
AMP PEAK 24(XQ25) WILD-TYPE | 171 | 1.4 (4.4) |
P value = 0.000303 (t-test), Q value = 0.23
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 181 | 577.6 (545.5) |
DEL PEAK 2(1Q23.1) MUTATED | 8 | 264.5 (163.8) |
DEL PEAK 2(1Q23.1) WILD-TYPE | 173 | 592.1 (552.8) |
P value = 0.000183 (t-test), Q value = 0.14
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 176 | 1.3 (4.3) |
DEL PEAK 9(4Q28.2) MUTATED | 11 | 0.1 (0.0) |
DEL PEAK 9(4Q28.2) WILD-TYPE | 165 | 1.4 (4.5) |
P value = 0.000257 (t-test), Q value = 0.19
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 205 | 3.5 (0.6) |
DEL PEAK 12(6Q14.3) MUTATED | 64 | 3.7 (0.6) |
DEL PEAK 12(6Q14.3) WILD-TYPE | 141 | 3.4 (0.5) |
P value = 0.000196 (t-test), Q value = 0.15
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 205 | 3.5 (0.6) |
DEL PEAK 13(8P21.3) MUTATED | 115 | 3.6 (0.6) |
DEL PEAK 13(8P21.3) WILD-TYPE | 90 | 3.3 (0.5) |
-
Copy number data file = transformed.cor.cli.txt
-
Clinical data file = PRAD-TP.merged_data.txt
-
Number of patients = 205
-
Number of significantly focal cnvs = 55
-
Number of selected clinical features = 14
-
Exclude genes that fewer than K tumors have mutations, K = 3
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.