Correlation between copy number variations of arm-level result and selected clinical features
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (Primary solid tumor)
02 April 2015  |  analyses__2015_04_02
Maintainer Information
Citation Information
doi:10.7908/C1930S5N
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2015): Correlation between copy number variations of arm-level result and selected clinical features. Broad Institute of MIT and Harvard. doi:10.7908/C1930S5N
Overview
Introduction

This pipeline computes the correlation between significant arm-level copy number variations (cnvs) and selected clinical features.

Summary

Testing the association between copy number variation 82 arm-level events and 44 clinical features across 292 patients, 16 significant findings detected with Q value < 0.25.

  • 9q gain cnv correlated to 'PREGNANCIES_COUNT_LIVE_BIRTH'.

  • xp gain cnv correlated to 'PREGNANCIES_COUNT_LIVE_BIRTH'.

  • 3p loss cnv correlated to 'NUMBER_OF_LYMPH_NODES' and 'LYMPH_NODES_EXAMINED_HE_COUNT'.

  • 4p loss cnv correlated to 'HISTOLOGICAL_TYPE'.

  • 7q loss cnv correlated to 'RADIATIONS_RADIATION_REGIMENINDICATION'.

  • 8p loss cnv correlated to 'TOBACCO_SMOKING_YEAR_STOPPED'.

  • 10q loss cnv correlated to 'NEOPLASM_HISTOLOGIC_GRADE'.

  • 11p loss cnv correlated to 'YEARS_TO_BIRTH' and 'AGE_AT_DIAGNOSIS'.

  • 11q loss cnv correlated to 'YEARS_TO_BIRTH' and 'AGE_AT_DIAGNOSIS'.

  • 16q loss cnv correlated to 'HISTOLOGICAL_TYPE'.

  • 18q loss cnv correlated to 'HISTOLOGICAL_TYPE'.

  • 19p loss cnv correlated to 'Time to Death'.

  • 20q loss cnv correlated to 'Time to Death'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between significant copy number variation of 82 arm-level events and 44 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 16 significant findings detected.

Clinical
Features 		Time
to
Death 		YEARS
TO
BIRTH 		PATHOLOGY
T
STAGE 		PATHOLOGY
N
STAGE 		PATHOLOGY
M
STAGE 		HISTOLOGICAL
TYPE 		RADIATIONS
RADIATION
REGIMENINDICATION 		NUMBER
PACK
YEARS
SMOKED 		NUMBER
OF
LYMPH
NODES 		RACE ETHNICITY WEIGHT
KG
AT
DIAGNOSIS 		TUMOR
STATUS 		TUMOR
SAMPLE
PROCUREMENT
COUNTRY 		NEOPLASM
HISTOLOGIC
GRADE 		TOBACCO
SMOKING
YEAR
STOPPED 		TOBACCO
SMOKING
PACK
YEARS
SMOKED 		TOBACCO
SMOKING
HISTORY 		PATIENT
AGEBEGANSMOKINGINYEARS 		RADIATION
TOTAL
DOSE 		RADIATION
THERAPY
TYPE 		RADIATION
THERAPY
STATUS 		RADIATION
THERAPY
SITE 		RADIATION
ADJUVANT
UNITS 		PREGNANCIES
COUNT
TOTAL 		PREGNANCIES
COUNT
STILLBIRTH 		PATIENT
PATIENTPREGNANCYSPONTANEOUSABORTIONCOUNT 		PREGNANCIES
COUNT
LIVE
BIRTH 		PATIENT
PATIENTPREGNANCYTHERAPEUTICABORTIONCOUNT 		PREGNANCIES
COUNT
ECTOPIC 		POS
LYMPH
NODE
LOCATION 		MENOPAUSE
STATUS 		LYMPHOVASCULAR
INVOLVEMENT 		LYMPH
NODES
EXAMINED
HE
COUNT 		LYMPH
NODES
EXAMINED 		KERATINIZATION
SQUAMOUS
CELL 		INITIAL
PATHOLOGIC
DX
YEAR 		HISTORY
HORMONAL
CONTRACEPTIVES
USE 		HEIGHT
CM
AT
DIAGNOSIS 		CORPUS
INVOLVEMENT 		CERVIX
SUV
RESULTS 		AJCC
TUMOR
PATHOLOGIC
PT 		AGE
AT
DIAGNOSIS 		STAGE
EVENT
CLINICAL
STAGE
nCNV (%) nWild-Type logrank test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Wilcoxon-test Wilcoxon-test Fisher's exact test Fisher's exact test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Wilcoxon-test Wilcoxon-test Fisher's exact test Wilcoxon-test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Wilcoxon-test Wilcoxon-test Wilcoxon-test Wilcoxon-test Wilcoxon-test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Wilcoxon-test Wilcoxon-test Fisher's exact test Wilcoxon-test Fisher's exact test Wilcoxon-test Fisher's exact test Wilcoxon-test Fisher's exact test Wilcoxon-test Fisher's exact test
3p loss 82 (28%) 210 0.895
(1.00) 		0.565
(0.999) 		0.35
(0.962) 		0.00978
(0.497) 		0.282
(0.927) 		0.00706
(0.479) 		0.136
(0.807) 		0.453
(0.993) 		0.000729
(0.213) 		0.678
(1.00) 		0.809
(1.00) 		0.851
(1.00) 		0.684
(1.00) 		0.891
(1.00) 		0.614
(1.00) 		0.155
(0.84) 		0.453
(0.993) 		0.00274
(0.33) 		0.234
(0.911) 		0.333
(0.959) 		0.251
(0.912) 		1
(1.00) 		0.632
(1.00) 		1
(1.00) 		0.921
(1.00) 		0.512
(0.997) 		0.826
(1.00) 		0.439
(0.993) 		0.755
(1.00) 		0.0304
(0.622) 		0.187
(0.858) 		0.867
(1.00) 		0.00155
(0.294) 		0.000729
(0.213) 		0.509
(0.997) 		0.581
(1.00) 		0.0383
(0.627) 		0.113
(0.787) 		0.0598
(0.674) 		0.368
(0.969) 		0.0149
(0.533) 		0.183
(0.85) 		0.493
(0.997) 		0.626
(1.00)
11p loss 99 (34%) 193 0.833
(1.00) 		0.000658
(0.213) 		0.299
(0.943) 		0.595
(1.00) 		0.496
(0.997) 		0.0555
(0.668) 		0.423
(0.989) 		0.26
(0.912) 		0.985
(1.00) 		0.285
(0.931) 		0.815
(1.00) 		0.916
(1.00) 		0.0377
(0.627) 		0.0251
(0.613) 		0.117
(0.792) 		0.397
(0.974) 		0.26
(0.912) 		0.779
(1.00) 		0.365
(0.967) 		0.351
(0.962) 		0.272
(0.917) 		0.551
(0.999) 		0.684
(1.00) 		0.356
(0.964) 		0.00683
(0.479) 		0.0401
(0.629) 		0.538
(0.999) 		0.0224
(0.597) 		0.409
(0.982) 		0.0364
(0.627) 		0.679
(1.00) 		0.0165
(0.558) 		0.456
(0.993) 		0.985
(1.00) 		0.521
(0.998) 		0.716
(1.00) 		0.258
(0.912) 		0.17
(0.84) 		0.0288
(0.622) 		0.389
(0.971) 		0.225
(0.9) 		0.292
(0.939) 		0.000644
(0.213) 		0.0516
(0.668)
11q loss 114 (39%) 178 0.829
(1.00) 		0.000131
(0.181) 		0.592
(1.00) 		1
(1.00) 		1
(1.00) 		0.172
(0.84) 		0.845
(1.00) 		0.805
(1.00) 		0.572
(1) 		0.276
(0.919) 		0.356
(0.964) 		0.697
(1.00) 		0.0715
(0.721) 		0.0719
(0.721) 		0.769
(1.00) 		0.676
(1.00) 		0.805
(1.00) 		0.539
(0.999) 		0.0516
(0.668) 		0.166
(0.84) 		0.692
(1.00) 		1
(1.00) 		0.646
(1.00) 		0.653
(1.00) 		0.031
(0.622) 		0.0556
(0.668) 		0.226
(0.9) 		0.0931
(0.751) 		0.087
(0.722) 		0.011
(0.503) 		0.637
(1.00) 		0.00193
(0.295) 		0.297
(0.941) 		0.572
(1) 		0.256
(0.912) 		0.86
(1.00) 		0.588
(1.00) 		0.753
(1.00) 		0.23
(0.901) 		0.172
(0.84) 		0.225
(0.9) 		0.147
(0.835) 		0.000201
(0.181) 		0.345
(0.962)
9q gain 47 (16%) 245 0.812
(1.00) 		0.16
(0.84) 		0.15
(0.836) 		0.0777
(0.721) 		1
(1.00) 		0.464
(0.995) 		0.19
(0.858) 		0.128
(0.799) 		0.113
(0.787) 		0.11
(0.787) 		0.488
(0.997) 		0.62
(1.00) 		0.168
(0.84) 		0.268
(0.914) 		0.504
(0.997) 		0.144
(0.828) 		0.128
(0.799) 		0.0406
(0.629) 		0.949
(1.00) 		0.615
(1.00) 		0.0224
(0.597) 		1
(1.00) 		0.612
(1.00) 		0.322
(0.955) 		0.223
(0.9) 		0.938
(1.00) 		0.0325
(0.622) 		0.00103
(0.233) 		0.638
(1.00) 		0.132
(0.801) 		0.762
(1.00) 		0.808
(1.00) 		1
(1.00) 		0.113
(0.787) 		0.814
(1.00) 		0.169
(0.84) 		0.651
(1.00) 		0.564
(0.999) 		0.5
(0.997) 		0.349
(0.962) 		0.95
(1.00) 		0.119
(0.793) 		0.203
(0.875) 		0.254
(0.912)
xp gain 42 (14%) 250 0.221
(0.899) 		0.34
(0.962) 		0.0716
(0.721) 		0.491
(0.997) 		0.0558
(0.668) 		0.625
(1.00) 		0.592
(1.00) 		0.125
(0.795) 		0.639
(1.00) 		0.473
(0.996) 		1
(1.00) 		0.0523
(0.668) 		0.632
(1.00) 		0.546
(0.999) 		0.521
(0.998) 		0.128
(0.799) 		0.125
(0.795) 		0.41
(0.982) 		0.395
(0.974) 		0.922
(1.00) 		1
(1.00) 		0.298
(0.941) 		0.84
(1.00) 		1
(1.00) 		0.00854
(0.483) 		0.0415
(0.629) 		0.342
(0.962) 		0.000959
(0.231) 		0.279
(0.92) 		0.804
(1.00) 		0.449
(0.993) 		0.497
(0.997) 		0.608
(1.00) 		0.639
(1.00) 		0.689
(1.00) 		0.494
(0.997) 		0.878
(1.00) 		0.178
(0.846) 		0.0744
(0.721) 		0.214
(0.885) 		0.405
(0.978) 		0.371
(0.969) 		0.702
(1.00)
4p loss 129 (44%) 163 0.584
(1.00) 		0.651
(1.00) 		0.127
(0.799) 		0.00851
(0.483) 		0.738
(1.00) 		0.00093
(0.231) 		0.334
(0.959) 		0.36
(0.964) 		0.00173
(0.294) 		0.302
(0.943) 		0.261
(0.912) 		0.0658
(0.706) 		0.858
(1.00) 		0.674
(1.00) 		0.145
(0.83) 		0.372
(0.969) 		0.36
(0.964) 		0.273
(0.918) 		0.805
(1.00) 		0.114
(0.787) 		0.963
(1.00) 		0.583
(1.00) 		0.314
(0.95) 		1
(1.00) 		0.241
(0.912) 		0.27
(0.916) 		1
(1.00) 		0.136
(0.806) 		0.205
(0.876) 		0.498
(0.997) 		0.626
(1.00) 		0.458
(0.993) 		0.173
(0.84) 		0.00173
(0.294) 		0.316
(0.951) 		0.391
(0.974) 		0.097
(0.752) 		0.744
(1.00) 		0.523
(0.998) 		0.785
(1.00) 		0.885
(1.00) 		0.399
(0.975) 		0.646
(1.00) 		0.472
(0.996)
7q loss 37 (13%) 255 0.122
(0.795) 		0.0264
(0.617) 		0.763
(1.00) 		0.451
(0.993) 		1
(1.00) 		0.339
(0.962) 		0.000305
(0.184) 		0.206
(0.876) 		0.135
(0.806) 		0.597
(1.00) 		0.134
(0.804) 		0.526
(0.999) 		0.189
(0.858) 		0.675
(1.00) 		0.381
(0.97) 		0.142
(0.824) 		0.206
(0.876) 		0.717
(1.00) 		0.425
(0.991) 		0.987
(1.00) 		0.00578
(0.479) 		0.543
(0.999) 		0.0164
(0.558) 		0.468
(0.996) 		0.318
(0.955) 		0.292
(0.94) 		0.247
(0.912) 		0.165
(0.84) 		0.157
(0.84) 		0.512
(0.997) 		0.259
(0.912) 		0.913
(1.00) 		0.348
(0.962) 		0.135
(0.806) 		0.928
(1.00) 		0.323
(0.955) 		0.513
(0.997) 		0.648
(1.00) 		0.41
(0.982) 		0.458
(0.993) 		0.955
(1.00) 		0.397
(0.974) 		0.0229
(0.597) 		0.914
(1.00)
8p loss 81 (28%) 211 0.0527
(0.668) 		0.489
(0.997) 		0.931
(1.00) 		0.714
(1.00) 		0.0606
(0.674) 		0.488
(0.997) 		0.132
(0.801) 		0.517
(0.997) 		0.497
(0.997) 		0.303
(0.943) 		1
(1.00) 		0.921
(1.00) 		0.234
(0.911) 		0.638
(1.00) 		0.157
(0.84) 		0.000769
(0.213) 		0.517
(0.997) 		0.385
(0.971) 		0.24
(0.912) 		0.169
(0.84) 		0.0824
(0.721) 		0.543
(0.999) 		0.315
(0.95) 		0.643
(1.00) 		0.965
(1.00) 		0.594
(1.00) 		0.557
(0.999) 		0.539
(0.999) 		0.672
(1.00) 		1
(1.00) 		0.724
(1.00) 		0.559
(0.999) 		0.123
(0.795) 		0.497
(0.997) 		0.62
(1.00) 		0.564
(0.999) 		0.571
(1) 		0.829
(1.00) 		0.801
(1.00) 		0.774
(1.00) 		0.393
(0.974) 		0.791
(1.00) 		0.457
(0.993) 		0.42
(0.986)
10q loss 74 (25%) 218 0.445
(0.993) 		0.0165
(0.558) 		0.507
(0.997) 		0.055
(0.668) 		0.687
(1.00) 		0.381
(0.97) 		0.181
(0.849) 		0.744
(1.00) 		0.0212
(0.597) 		0.0311
(0.622) 		0.801
(1.00) 		0.981
(1.00) 		0.418
(0.985) 		0.26
(0.912) 		0.00036
(0.186) 		0.82
(1.00) 		0.744
(1.00) 		0.147
(0.835) 		0.264
(0.912) 		0.412
(0.984) 		0.207
(0.876) 		1
(1.00) 		0.0497
(0.655) 		1
(1.00) 		0.164
(0.84) 		0.682
(1.00) 		0.259
(0.912) 		0.0792
(0.721) 		0.737
(1.00) 		0.489
(0.997) 		0.00719
(0.479) 		0.223
(0.9) 		0.0532
(0.668) 		0.0212
(0.597) 		0.6
(1.00) 		0.435
(0.993) 		0.25
(0.912) 		0.808
(1.00) 		0.111
(0.787) 		0.754
(1.00) 		0.526
(0.999) 		0.118
(0.792) 		0.0195
(0.591) 		0.524
(0.998)
16q loss 44 (15%) 248 0.743
(1.00) 		0.159
(0.84) 		0.732
(1.00) 		0.0139
(0.527) 		1
(1.00) 		6e-05
(0.181) 		0.789
(1.00) 		0.382
(0.97) 		0.0738
(0.721) 		0.203
(0.875) 		0.743
(1.00) 		0.669
(1.00) 		0.601
(1.00) 		0.836
(1.00) 		0.15
(0.836) 		0.83
(1.00) 		0.382
(0.97) 		0.359
(0.964) 		0.423
(0.99) 		0.251
(0.912) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		0.211
(0.884) 		0.938
(1.00) 		0.962
(1.00) 		0.482
(0.997) 		0.278
(0.92) 		0.512
(0.997) 		0.94
(1.00) 		0.44
(0.993) 		0.815
(1.00) 		0.0738
(0.721) 		0.532
(0.999) 		0.0542
(0.668) 		0.301
(0.943) 		1
(1.00) 		0.326
(0.955) 		0.458
(0.993) 		0.458
(0.993) 		0.127
(0.799) 		0.884
(1.00)
18q loss 73 (25%) 219 0.865
(1.00) 		0.929
(1.00) 		0.64
(1.00) 		0.123
(0.795) 		0.458
(0.993) 		0.00019
(0.181) 		0.508
(0.997) 		0.263
(0.912) 		0.0417
(0.629) 		0.987
(1.00) 		0.788
(1.00) 		0.177
(0.846) 		0.416
(0.984) 		0.888
(1.00) 		0.574
(1) 		0.407
(0.98) 		0.263
(0.912) 		0.356
(0.964) 		0.475
(0.997) 		0.835
(1.00) 		0.919
(1.00) 		1
(1.00) 		0.821
(1.00) 		1
(1.00) 		0.0864
(0.722) 		0.163
(0.84) 		0.873
(1.00) 		0.124
(0.795) 		0.894
(1.00) 		0.879
(1.00) 		0.52
(0.998) 		0.585
(1.00) 		0.1
(0.761) 		0.0417
(0.629) 		0.333
(0.959) 		1
(1.00) 		0.0451
(0.638) 		0.255
(0.912) 		0.693
(1.00) 		0.0213
(0.597) 		0.486
(0.997) 		0.856
(1.00) 		0.0836
(0.721)
19p loss 60 (21%) 232 0.00052
(0.213) 		0.437
(0.993) 		0.364
(0.966) 		0.198
(0.873) 		1
(1.00) 		0.511
(0.997) 		0.351
(0.962) 		0.214
(0.885) 		0.186
(0.855) 		0.246
(0.912) 		0.258
(0.912) 		0.689
(1.00) 		0.163
(0.84) 		0.291
(0.939) 		0.262
(0.912) 		0.45
(0.993) 		0.214
(0.885) 		0.906
(1.00) 		0.117
(0.792) 		0.805
(1.00) 		0.586
(1.00) 		0.551
(0.999) 		0.783
(1.00) 		1
(1.00) 		0.509
(0.997) 		0.213
(0.885) 		0.712
(1.00) 		0.713
(1.00) 		0.802
(1.00) 		0.804
(1.00) 		1
(1.00) 		0.385
(0.971) 		0.827
(1.00) 		0.186
(0.855) 		0.877
(1.00) 		1
(1.00) 		0.199
(0.874) 		0.536
(0.999) 		0.0301
(0.622) 		0.314
(0.95) 		0.282
(0.927) 		0.907
(1.00) 		0.495
(0.997) 		0.971
(1.00)
20q loss 10 (3%) 282 0.000282
(0.184) 		0.0646
(0.702) 		0.539
(0.999) 		0.325
(0.955) 		0.304
(0.943) 		0.722
(1.00) 		0.606
(1.00) 		0.0499
(0.655) 		0.132
(0.801) 		0.412
(0.984) 		1
(1.00) 		0.0287
(0.622) 		1
(1.00) 		0.296
(0.941) 		0.314
(0.95) 		0.0499
(0.655) 		0.295
(0.941) 		0.578
(1.00) 		0.591
(1.00) 		0.766
(1.00) 		1
(1.00) 		0.775
(1.00) 		0.684
(1.00) 		0.114
(0.787) 		0.479
(0.997) 		0.715
(1.00) 		0.55
(0.999) 		1
(1.00) 		0.0758
(0.721) 		1
(1.00) 		0.132
(0.801) 		0.716
(1.00) 		0.0758
(0.721) 		0.868
(1.00) 		0.416
(0.985) 		0.356
(0.964) 		0.289
(0.939) 		0.903
(1.00) 		0.0589
(0.673) 		0.983
(1.00)
1p gain 90 (31%) 202 0.964
(1.00) 		0.00866
(0.483) 		0.112
(0.787) 		0.726
(1.00) 		1
(1.00) 		0.0562
(0.668) 		0.681
(1.00) 		0.169
(0.84) 		0.176
(0.846) 		0.121
(0.795) 		1
(1.00) 		0.42
(0.986) 		1
(1.00) 		0.598
(1.00) 		0.16
(0.84) 		0.878
(1.00) 		0.169
(0.84) 		0.431
(0.992) 		0.466
(0.995) 		0.643
(1.00) 		0.0767
(0.721) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		0.108
(0.784) 		0.307
(0.948) 		0.839
(1.00) 		0.268
(0.914) 		0.551
(0.999) 		0.433
(0.993) 		0.447
(0.993) 		0.0117
(0.512) 		0.719
(1.00) 		0.176
(0.846) 		0.922
(1.00) 		1
(1.00) 		0.679
(1.00) 		0.16
(0.84) 		0.0323
(0.622) 		0.389
(0.971) 		0.136
(0.806) 		0.199
(0.874) 		0.00777
(0.479) 		0.161
(0.84)
1q gain 140 (48%) 152 0.727
(1.00) 		0.242
(0.912) 		0.133
(0.801) 		0.748
(1.00) 		0.322
(0.955) 		0.105
(0.78) 		0.34
(0.962) 		0.546
(0.999) 		0.625
(1.00) 		0.00784
(0.479) 		0.825
(1.00) 		0.124
(0.795) 		0.597
(1.00) 		0.619
(1.00) 		0.258
(0.912) 		0.846
(1.00) 		0.546
(0.999) 		0.604
(1.00) 		0.993
(1.00) 		0.479
(0.997) 		0.00196
(0.295) 		1
(1.00) 		0.753
(1.00) 		0.671
(1.00) 		0.444
(0.993) 		0.265
(0.912) 		0.321
(0.955) 		0.66
(1.00) 		0.871
(1.00) 		0.123
(0.795) 		0.247
(0.912) 		0.147
(0.835) 		0.402
(0.978) 		0.625
(1.00) 		0.865
(1.00) 		0.493
(0.997) 		0.752
(1.00) 		0.405
(0.978) 		0.0219
(0.597) 		0.79
(1.00) 		0.291
(0.939) 		0.0296
(0.622) 		0.211
(0.884) 		0.871
(1.00)
2p gain 64 (22%) 228 0.753
(1.00) 		0.447
(0.993) 		0.6
(1.00) 		1
(1.00) 		0.443
(0.993) 		0.674
(1.00) 		0.642
(1.00) 		0.171
(0.84) 		0.991
(1.00) 		0.485
(0.997) 		1
(1.00) 		0.0246
(0.613) 		0.283
(0.929) 		0.258
(0.912) 		0.524
(0.998) 		0.31
(0.95) 		0.171
(0.84) 		0.902
(1.00) 		0.595
(1.00) 		0.263
(0.912) 		0.768
(1.00) 		1
(1.00) 		0.56
(0.999) 		0.627
(1.00) 		0.614
(1.00) 		0.242
(0.912) 		0.546
(0.999) 		0.37
(0.969) 		0.547
(0.999) 		0.113
(0.787) 		0.866
(1.00) 		0.982
(1.00) 		0.531
(0.999) 		0.991
(1.00) 		0.908
(1.00) 		0.824
(1.00) 		0.796
(1.00) 		0.595
(1.00) 		0.745
(1.00) 		0.0923
(0.749) 		0.35
(0.962) 		0.399
(0.975) 		0.355
(0.964)
2q gain 37 (13%) 255 0.349
(0.962) 		0.837
(1.00) 		0.591
(1.00) 		0.0786
(0.721) 		0.615
(1.00) 		0.478
(0.997) 		0.779
(1.00) 		0.473
(0.996) 		0.0574
(0.668) 		0.903
(1.00) 		1
(1.00) 		0.06
(0.674) 		0.418
(0.985) 		0.442
(0.993) 		0.414
(0.984) 		0.0562
(0.668) 		0.473
(0.996) 		0.595
(1.00) 		0.434
(0.993) 		0.937
(1.00) 		0.817
(1.00) 		1
(1.00) 		1
(1.00) 		0.185
(0.853) 		0.164
(0.84) 		0.398
(0.974) 		0.46
(0.993) 		0.13
(0.8) 		0.97
(1.00) 		0.0598
(0.674) 		0.472
(0.996) 		0.845
(1.00) 		0.037
(0.627) 		0.0574
(0.668) 		0.566
(1) 		1
(1.00) 		0.725
(1.00) 		0.428
(0.992) 		0.575
(1.00) 		0.0676
(0.706) 		0.189
(0.858) 		0.718
(1.00) 		0.849
(1.00)
3p gain 70 (24%) 222 0.0269
(0.617) 		0.399
(0.975) 		0.428
(0.992) 		1
(1.00) 		0.236
(0.912) 		0.589
(1.00) 		0.498
(0.997) 		0.155
(0.84) 		0.975
(1.00) 		0.407
(0.98) 		1
(1.00) 		0.263
(0.912) 		0.0961
(0.752) 		0.165
(0.84) 		0.165
(0.84) 		0.965
(1.00) 		0.155
(0.84) 		0.988
(1.00) 		0.476
(0.997) 		0.0941
(0.751) 		0.247
(0.912) 		0.536
(0.999) 		0.708
(1.00) 		1
(1.00) 		0.678
(1.00) 		0.638
(1.00) 		0.864
(1.00) 		0.328
(0.956) 		0.655
(1.00) 		0.183
(0.85) 		0.348
(0.962) 		0.32
(0.955) 		0.836
(1.00) 		0.975
(1.00) 		0.706
(1.00) 		1
(1.00) 		0.149
(0.836) 		1
(1.00) 		0.612
(1.00) 		0.754
(1.00) 		0.157
(0.84) 		0.78
(1.00) 		0.424
(0.99) 		0.533
(0.999)
3q gain 174 (60%) 118 0.494
(0.997) 		0.96
(1.00) 		0.454
(0.993) 		0.0131
(0.512) 		1
(1.00) 		0.0174
(0.558) 		0.119
(0.793) 		0.17
(0.84) 		0.0146
(0.529) 		0.208
(0.876) 		0.373
(0.969) 		0.0579
(0.67) 		0.587
(1.00) 		0.282
(0.927) 		0.76
(1.00) 		0.849
(1.00) 		0.17
(0.84) 		0.794
(1.00) 		0.426
(0.992) 		0.904
(1.00) 		0.394
(0.974) 		1
(1.00) 		0.261
(0.912) 		1
(1.00) 		0.413
(0.984) 		0.596
(1.00) 		0.972
(1.00) 		0.717
(1.00) 		0.543
(0.999) 		0.895
(1.00) 		0.956
(1.00) 		0.307
(0.948) 		0.237
(0.912) 		0.0146
(0.529) 		0.894
(1.00) 		0.862
(1.00) 		0.26
(0.912) 		0.591
(1.00) 		0.514
(0.997) 		1
(1.00) 		0.155
(0.84) 		0.491
(0.997) 		0.844
(1.00) 		0.228
(0.901)
4p gain 11 (4%) 281 0.879
(1.00) 		0.334
(0.959) 		0.682
(1.00) 		0.677
(1.00) 		1
(1.00) 		0.482
(0.997) 		1
(1.00) 		0.605
(1.00) 		0.342
(0.962) 		0.22
(0.898) 		1
(1.00) 		0.998
(1.00) 		1
(1.00) 		0.501
(0.997) 		0.373
(0.969) 		0.605
(1.00) 		1
(1.00) 		0.369
(0.969) 		0.646
(1.00) 		1
(1.00) 		0.361
(0.965) 		0.158
(0.84) 		0.43
(0.992) 		0.684
(1.00) 		0.222
(0.9) 		0.259
(0.912) 		0.715
(1.00) 		0.55
(0.999) 		0.879
(1.00) 		1
(1.00) 		0.342
(0.962) 		0.483
(0.997) 		1
(1.00) 		0.236
(0.912) 		1
(1.00) 		0.818
(1.00) 		1
(1.00) 		0.694
(1.00) 		0.345
(0.962) 		0.563
(0.999)
4q gain 16 (5%) 276 0.442
(0.993) 		0.781
(1.00) 		0.941
(1.00) 		1
(1.00) 		0.474
(0.997) 		0.496
(0.997) 		0.387
(0.971) 		0.313
(0.95) 		0.447
(0.993) 		0.561
(0.999) 		1
(1.00) 		0.986
(1.00) 		1
(1.00) 		0.728
(1.00) 		0.485
(0.997) 		0.313
(0.95) 		0.873
(1.00) 		0.809
(1.00) 		0.682
(1.00) 		0.861
(1.00) 		1
(1.00) 		0.23
(0.901) 		0.493
(0.997) 		0.684
(1.00) 		0.222
(0.9) 		0.561
(0.999) 		0.715
(1.00) 		0.55
(0.999) 		1
(1.00) 		0.569
(1) 		0.494
(0.997) 		0.447
(0.993) 		1
(1.00) 		0.106
(0.784) 		0.478
(0.997) 		0.686
(1.00) 		0.936
(1.00) 		1
(1.00) 		0.437
(0.993) 		0.759
(1.00) 		0.68
(1.00)
5p gain 112 (38%) 180 0.83
(1.00) 		0.819
(1.00) 		0.14
(0.817) 		1
(1.00) 		0.0861
(0.721) 		0.0478
(0.65) 		0.428
(0.992) 		0.0419
(0.629) 		0.866
(1.00) 		0.459
(0.993) 		0.0386
(0.627) 		0.991
(1.00) 		0.855
(1.00) 		0.569
(1) 		0.0835
(0.721) 		0.827
(1.00) 		0.0419
(0.629) 		0.858
(1.00) 		0.565
(0.999) 		0.239
(0.912) 		0.391
(0.974) 		0.53
(0.999) 		0.313
(0.95) 		1
(1.00) 		0.0803
(0.721) 		0.397
(0.974) 		0.774
(1.00) 		0.0205
(0.597) 		0.112
(0.787) 		0.297
(0.941) 		0.884
(1.00) 		0.322
(0.955) 		0.855
(1.00) 		0.866
(1.00) 		0.046
(0.642) 		0.22
(0.898) 		0.523
(0.998) 		0.818
(1.00) 		0.784
(1.00) 		0.571
(1) 		0.665
(1.00) 		0.0391
(0.629) 		0.706
(1.00) 		0.011
(0.503)
5q gain 44 (15%) 248 0.753
(1.00) 		0.753
(1.00) 		0.0778
(0.721) 		0.809
(1.00) 		0.357
(0.964) 		0.558
(0.999) 		1
(1.00) 		0.17
(0.84) 		0.387
(0.971) 		0.698
(1.00) 		1
(1.00) 		0.743
(1.00) 		1
(1.00) 		0.0961
(0.752) 		0.641
(1.00) 		0.83
(1.00) 		0.17
(0.84) 		0.962
(1.00) 		0.837
(1.00) 		0.522
(0.998) 		0.581
(1.00) 		1
(1.00) 		0.856
(1.00) 		1
(1.00) 		0.332
(0.959) 		0.824
(1.00) 		0.533
(0.999) 		0.315
(0.95) 		0.558
(0.999) 		0.163
(0.84) 		0.827
(1.00) 		0.0576
(0.668) 		0.445
(0.993) 		0.387
(0.971) 		0.866
(1.00) 		0.467
(0.996) 		0.247
(0.912) 		0.725
(1.00) 		0.872
(1.00) 		0.12
(0.795) 		0.571
(1) 		0.263
(0.912) 		0.767
(1.00) 		0.665
(1.00)
6p gain 52 (18%) 240 0.312
(0.95) 		0.293
(0.94) 		0.96
(1.00) 		0.201
(0.875) 		0.68
(1.00) 		0.587
(1.00) 		0.0779
(0.721) 		0.293
(0.94) 		0.329
(0.956) 		0.854
(1.00) 		0.774
(1.00) 		0.497
(0.997) 		0.0499
(0.655) 		0.33
(0.958) 		0.048
(0.65) 		0.86
(1.00) 		0.293
(0.94) 		0.516
(0.997) 		0.523
(0.998) 		0.904
(1.00) 		0.0612
(0.678) 		0.53
(0.999) 		0.686
(1.00) 		0.218
(0.892) 		0.5
(0.997) 		0.792
(1.00) 		0.312
(0.95) 		0.267
(0.914) 		0.805
(1.00) 		0.681
(1.00) 		0.881
(1.00) 		0.87
(1.00) 		0.374
(0.969) 		0.329
(0.956) 		0.759
(1.00) 		0.819
(1.00) 		0.18
(0.849) 		0.138
(0.811) 		0.258
(0.912) 		0.272
(0.917) 		0.562
(0.999) 		0.336
(0.961) 		0.333
(0.959) 		0.163
(0.84)
6q gain 36 (12%) 256 0.0632
(0.69) 		0.447
(0.993) 		0.203
(0.875) 		0.618
(1.00) 		1
(1.00) 		0.238
(0.912) 		0.0732
(0.721) 		0.264
(0.912) 		0.928
(1.00) 		1
(1.00) 		0.161
(0.84) 		0.211
(0.884) 		0.0273
(0.618) 		0.226
(0.901) 		0.0923
(0.749) 		0.46
(0.993) 		0.264
(0.912) 		0.74
(1.00) 		0.41
(0.982) 		0.227
(0.901) 		0.132
(0.801) 		0.551
(0.999) 		0.856
(1.00) 		0.154
(0.84) 		0.163
(0.84) 		0.926
(1.00) 		0.626
(1.00) 		0.263
(0.912) 		0.917
(1.00) 		0.484
(0.997) 		0.873
(1.00) 		1
(1.00) 		0.789
(1.00) 		0.928
(1.00) 		0.468
(0.996) 		0.58
(1.00) 		0.5
(0.997) 		0.27
(0.916) 		0.443
(0.993) 		0.188
(0.858) 		0.958
(1.00) 		0.251
(0.912) 		0.493
(0.997) 		0.469
(0.996)
7p gain 38 (13%) 254 0.47
(0.996) 		0.149
(0.836) 		0.00529
(0.479) 		1
(1.00) 		0.066
(0.706) 		0.928
(1.00) 		1
(1.00) 		0.0258
(0.613) 		0.345
(0.962) 		0.794
(1.00) 		0.488
(0.997) 		0.971
(1.00) 		0.189
(0.858) 		0.674
(1.00) 		0.537
(0.999) 		0.83
(1.00) 		0.0258
(0.613) 		0.615
(1.00) 		0.0757
(0.721) 		0.3
(0.943) 		1
(1.00) 		0.382
(0.97) 		0.904
(1.00) 		0.252
(0.912) 		0.125
(0.795) 		0.698
(1.00) 		0.673
(1.00) 		0.038
(0.627) 		0.52
(0.998) 		0.755
(1.00) 		0.143
(0.826) 		0.362
(0.965) 		0.13
(0.801) 		0.345
(0.962) 		0.99
(1.00) 		1
(1.00) 		0.428
(0.992) 		0.91
(1.00) 		0.434
(0.993) 		0.654
(1.00) 		0.00242
(0.312) 		0.152
(0.84) 		0.0289
(0.622)
7q gain 37 (13%) 255 0.689
(1.00) 		0.0401
(0.629) 		0.00318
(0.359) 		0.593
(1.00) 		0.0817
(0.721) 		0.77
(1.00) 		0.241
(0.912) 		0.16
(0.84) 		0.545
(0.999) 		0.511
(0.997) 		0.712
(1.00) 		0.434
(0.993) 		0.602
(1.00) 		0.444
(0.993) 		0.481
(0.997) 		0.256
(0.912) 		0.16
(0.84) 		0.182
(0.849) 		0.256
(0.912) 		0.34
(0.962) 		0.766
(1.00) 		0.53
(0.999) 		0.798
(1.00) 		1
(1.00) 		0.926
(1.00) 		0.762
(1.00) 		0.537
(0.999) 		0.407
(0.98) 		0.197
(0.872) 		0.182
(0.849) 		0.597
(1.00) 		0.463
(0.995) 		0.368
(0.969) 		0.545
(0.999) 		0.868
(1.00) 		1
(1.00) 		0.126
(0.799) 		1
(1.00) 		0.974
(1.00) 		1
(1.00) 		0.00872
(0.483) 		0.0426
(0.629) 		0.514
(0.997)
8p gain 53 (18%) 239 0.561
(0.999) 		0.115
(0.787) 		0.0318
(0.622) 		0.547
(0.999) 		0.105
(0.78) 		0.247
(0.912) 		1
(1.00) 		0.529
(0.999) 		0.716
(1.00) 		0.706
(1.00) 		1
(1.00) 		0.994
(1.00) 		0.82
(1.00) 		0.214
(0.885) 		0.677
(1.00) 		0.549
(0.999) 		0.529
(0.999) 		0.21
(0.884) 		0.977
(1.00) 		0.00304
(0.354) 		0.116
(0.79) 		1
(1.00) 		0.428
(0.992) 		0.518
(0.997) 		0.112
(0.787) 		0.377
(0.97) 		0.955
(1.00) 		0.383
(0.971) 		0.0532
(0.668) 		0.615
(1.00) 		0.518
(0.997) 		0.288
(0.939) 		0.505
(0.997) 		0.716
(1.00) 		0.237
(0.912) 		1
(1.00) 		0.515
(0.997) 		0.129
(0.8) 		0.49
(0.997) 		1
(1.00) 		0.61
(1.00) 		0.0485
(0.653) 		0.108
(0.784) 		0.818
(1.00)
8q gain 91 (31%) 201 0.984
(1.00) 		0.112
(0.787) 		0.00217
(0.301) 		0.298
(0.941) 		0.29
(0.939) 		0.0201
(0.597) 		0.213
(0.885) 		0.879
(1.00) 		0.712
(1.00) 		0.75
(1.00) 		0.634
(1.00) 		0.217
(0.89) 		0.7
(1.00) 		0.762
(1.00) 		0.951
(1.00) 		0.336
(0.961) 		0.879
(1.00) 		0.546
(0.999) 		0.985
(1.00) 		0.00171
(0.294) 		0.534
(0.999) 		0.53
(0.999) 		0.413
(0.984) 		0.589
(1.00) 		0.898
(1.00) 		0.638
(1.00) 		0.266
(0.914) 		0.91
(1.00) 		0.195
(0.869) 		0.544
(0.999) 		0.252
(0.912) 		0.552
(0.999) 		0.441
(0.993) 		0.712
(1.00) 		0.309
(0.95) 		0.37
(0.969) 		0.119
(0.793) 		0.133
(0.801) 		0.694
(1.00) 		1
(1.00) 		0.961
(1.00) 		0.00533
(0.479) 		0.105
(0.78) 		0.314
(0.95)
9p gain 49 (17%) 243 0.659
(1.00) 		0.0621
(0.683) 		0.0749
(0.721) 		0.0777
(0.721) 		1
(1.00) 		0.988
(1.00) 		0.193
(0.865) 		0.267
(0.914) 		0.155
(0.84) 		0.0706
(0.721) 		0.307
(0.948) 		0.944
(1.00) 		0.0104
(0.503) 		0.265
(0.912) 		0.674
(1.00) 		0.34
(0.962) 		0.267
(0.914) 		0.172
(0.84) 		0.546
(0.999) 		0.941
(1.00) 		0.0378
(0.627) 		1
(1.00) 		0.938
(1.00) 		0.612
(1.00) 		0.736
(1.00) 		0.879
(1.00) 		0.0923
(0.749) 		0.0414
(0.629) 		0.447
(0.993) 		0.0846
(0.721) 		0.739
(1.00) 		0.692
(1.00) 		0.818
(1.00) 		0.155
(0.84) 		0.404
(0.978) 		0.0474
(0.65) 		0.322
(0.955) 		0.893
(1.00) 		0.78
(1.00) 		0.207
(0.876) 		0.85
(1.00) 		0.06
(0.674) 		0.0525
(0.668) 		0.256
(0.912)
10p gain 25 (9%) 267 0.624
(1.00) 		0.722
(1.00) 		0.0796
(0.721) 		0.0885
(0.726) 		1
(1.00) 		0.684
(1.00) 		1
(1.00) 		0.721
(1.00) 		0.0319
(0.622) 		0.967
(1.00) 		0.476
(0.997) 		0.17
(0.84) 		0.721
(1.00) 		0.68
(1.00) 		0.842
(1.00) 		0.378
(0.97) 		0.721
(1.00) 		0.144
(0.826) 		0.0429
(0.629) 		0.25
(0.912) 		0.226
(0.9) 		1
(1.00) 		0.315
(0.95) 		1
(1.00) 		0.894
(1.00) 		0.513
(0.997) 		0.925
(1.00) 		0.404
(0.978) 		0.434
(0.993) 		0.278
(0.92) 		0.875
(1.00) 		0.95
(1.00) 		0.368
(0.969) 		0.0319
(0.622) 		0.667
(1.00) 		0.141
(0.819) 		0.224
(0.9) 		0.652
(1.00) 		0.338
(0.962) 		1
(1.00) 		0.475
(0.997) 		0.759
(1.00) 		0.784
(1.00)
10q gain 17 (6%) 275 0.998
(1.00) 		0.92
(1.00) 		0.243
(0.912) 		0.189
(0.858) 		1
(1.00) 		0.469
(0.996) 		1
(1.00) 		0.184
(0.851) 		0.253
(0.912) 		0.933
(1.00) 		0.176
(0.846) 		0.222
(0.9) 		0.439
(0.993) 		0.4
(0.975) 		0.532
(0.999) 		0.607
(1.00) 		0.184
(0.851) 		0.15
(0.836) 		0.352
(0.962) 		0.822
(1.00) 		0.417
(0.985) 		1
(1.00) 		0.358
(0.964) 		1
(1.00) 		0.663
(1.00) 		0.587
(1.00) 		0.687
(1.00) 		0.427
(0.992) 		0.626
(1.00) 		0.136
(0.806) 		1
(1.00) 		0.642
(1.00) 		1
(1.00) 		0.253
(0.912) 		0.871
(1.00) 		0.722
(1.00) 		0.39
(0.974) 		0.276
(0.919) 		0.0476
(0.65) 		1
(1.00) 		0.15
(0.836) 		0.89
(1.00) 		0.781
(1.00)
11p gain 9 (3%) 283 0.968
(1.00) 		0.12
(0.794) 		0.175
(0.845) 		0.639
(1.00) 		0.304
(0.943) 		0.507
(0.997) 		0.234
(0.911) 		0.202
(0.875) 		1
(1.00) 		0.417
(0.985) 		0.193
(0.864) 		0.553
(0.999) 		1
(1.00) 		0.741
(1.00) 		0.129
(0.8) 		0.877
(1.00) 		0.0819
(0.721) 		1
(1.00) 		0.669
(1.00) 		0.23
(0.901) 		0.414
(0.984) 		0.775
(1.00) 		0.972
(1.00) 		0.584
(1.00) 		0.158
(0.84) 		0.676
(1.00) 		0.202
(0.875) 		0.767
(1.00) 		1
(1.00) 		0.515
(0.997) 		0.0385
(0.627) 		0.721
(1.00) 		1
(1.00) 		0.00669
(0.479) 		0.114
(0.787) 		0.51
(0.997)
11q gain 8 (3%) 284 0.663
(1.00) 		0.245
(0.912) 		0.663
(1.00) 		0.369
(0.969) 		0.304
(0.943) 		0.451
(0.993) 		0.194
(0.866) 		0.0326
(0.622) 		0.776
(1.00) 		0.491
(0.997) 		0.667
(1.00) 		0.553
(0.999) 		0.272
(0.917) 		0.0292
(0.622) 		0.0972
(0.752) 		0.964
(1.00) 		0.0308
(0.622) 		1
(1.00) 		0.082
(0.721) 		0.327
(0.955) 		0.781
(1.00) 		0.492
(0.997) 		0.584
(1.00) 		0.189
(0.858) 		1
(1.00) 		0.0326
(0.622) 		0.365
(0.967) 		1
(1.00) 		0.263
(0.912) 		0.773
(1.00) 		1
(1.00) 		0.0236
(0.597) 		0.323
(0.955) 		0.589
(1.00)
12p gain 53 (18%) 239 0.894
(1.00) 		0.0699
(0.716) 		0.138
(0.811) 		1
(1.00) 		0.211
(0.884) 		0.976
(1.00) 		0.454
(0.993) 		0.023
(0.597) 		0.854
(1.00) 		0.697
(1.00) 		0.771
(1.00) 		0.344
(0.962) 		1
(1.00) 		0.774
(1.00) 		0.471
(0.996) 		0.774
(1.00) 		0.023
(0.597) 		0.132
(0.801) 		0.486
(0.997) 		0.8
(1.00) 		0.858
(1.00) 		0.551
(0.999) 		0.0851
(0.721) 		1
(1.00) 		0.0447
(0.635) 		0.879
(1.00) 		0.654
(1.00) 		0.0689
(0.71) 		0.424
(0.99) 		0.205
(0.876) 		0.816
(1.00) 		0.672
(1.00) 		0.524
(0.998) 		0.854
(1.00) 		0.348
(0.962) 		0.0183
(0.569) 		0.788
(1.00) 		0.653
(1.00) 		0.903
(1.00) 		1
(1.00) 		0.692
(1.00) 		0.0171
(0.558) 		0.0842
(0.721) 		0.445
(0.993)
12q gain 50 (17%) 242 0.745
(1.00) 		0.0918
(0.749) 		0.336
(0.961) 		0.687
(1.00) 		0.41
(0.982) 		0.876
(1.00) 		0.196
(0.871) 		0.157
(0.84) 		0.969
(1.00) 		0.755
(1.00) 		0.765
(1.00) 		0.201
(0.875) 		1
(1.00) 		0.598
(1.00) 		0.0356
(0.627) 		0.676
(1.00) 		0.157
(0.84) 		0.176
(0.845) 		0.443
(0.993) 		0.889
(1.00) 		0.522
(0.998) 		0.536
(0.999) 		0.133
(0.801) 		1
(1.00) 		0.012
(0.512) 		0.991
(1.00) 		0.961
(1.00) 		0.0258
(0.613) 		0.733
(1.00) 		0.022
(0.597) 		1
(1.00) 		0.35
(0.962) 		1
(1.00) 		0.969
(1.00) 		0.959
(1.00) 		0.0858
(0.721) 		0.886
(1.00) 		0.708
(1.00) 		0.586
(1.00) 		0.492
(0.997) 		0.225
(0.9) 		0.124
(0.795) 		0.101
(0.761) 		0.535
(0.999)
13q gain 24 (8%) 268 0.0157
(0.555) 		0.802
(1.00) 		0.679
(1.00) 		0.78
(1.00) 		0.596
(1.00) 		0.0265
(0.617) 		1
(1.00) 		0.624
(1.00) 		0.578
(1.00) 		0.968
(1.00) 		0.223
(0.9) 		0.459
(0.993) 		0.0974
(0.753) 		0.0238
(0.597) 		0.968
(1.00) 		0.624
(1.00) 		0.546
(0.999) 		0.312
(0.95) 		0.351
(0.962) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		0.515
(0.997) 		0.451
(0.993) 		0.464
(0.995) 		0.863
(1.00) 		0.237
(0.912) 		1
(1.00) 		1
(1.00) 		0.672
(1.00) 		1
(1.00) 		0.578
(1.00) 		0.367
(0.969) 		0.511
(0.997) 		0.405
(0.978) 		0.555
(0.999) 		0.804
(1.00) 		0.349
(0.962) 		0.409
(0.982) 		0.832
(1.00) 		0.586
(1.00)
14q gain 47 (16%) 245 0.462
(0.994) 		0.619
(1.00) 		0.343
(0.962) 		0.821
(1.00) 		1
(1.00) 		0.749
(1.00) 		1
(1.00) 		0.173
(0.84) 		0.376
(0.969) 		0.49
(0.997) 		0.57
(1) 		0.101
(0.761) 		1
(1.00) 		0.259
(0.912) 		0.647
(1.00) 		0.331
(0.958) 		0.173
(0.84) 		0.172
(0.84) 		0.933
(1.00) 		0.816
(1.00) 		0.62
(1.00) 		1
(1.00) 		0.755
(1.00) 		1
(1.00) 		0.0672
(0.706) 		0.275
(0.919) 		0.382
(0.97) 		0.109
(0.787) 		0.131
(0.801) 		0.421
(0.988) 		0.873
(1.00) 		0.439
(0.993) 		1
(1.00) 		0.376
(0.969) 		0.754
(1.00) 		0.49
(0.997) 		0.245
(0.912) 		0.0481
(0.65) 		0.927
(1.00) 		1
(1.00) 		0.95
(1.00) 		0.428
(0.992) 		0.559
(0.999) 		0.764
(1.00)
15q gain 52 (18%) 240 0.919
(1.00) 		0.0691
(0.71) 		0.0403
(0.629) 		0.831
(1.00) 		0.205
(0.876) 		0.0332
(0.624) 		0.449
(0.993) 		0.119
(0.793) 		0.862
(1.00) 		0.295
(0.941) 		0.777
(1.00) 		0.579
(1.00) 		1
(1.00) 		0.832
(1.00) 		0.361
(0.965) 		0.302
(0.943) 		0.119
(0.793) 		0.634
(1.00) 		0.865
(1.00) 		0.994
(1.00) 		0.948
(1.00) 		1
(1.00) 		0.387
(0.971) 		1
(1.00) 		0.0627
(0.688) 		0.47
(0.996) 		0.522
(0.998) 		0.129
(0.8) 		0.805
(1.00) 		0.748
(1.00) 		0.766
(1.00) 		0.223
(0.9) 		0.83
(1.00) 		0.862
(1.00) 		0.912
(1.00) 		0.492
(0.997) 		0.788
(1.00) 		0.54
(0.999) 		0.791
(1.00) 		0.727
(1.00) 		0.0208
(0.597) 		0.0561
(0.668) 		0.285
(0.931)
16p gain 44 (15%) 248 0.622
(1.00) 		0.767
(1.00) 		0.199
(0.874) 		0.276
(0.919) 		0.685
(1.00) 		0.944
(1.00) 		1
(1.00) 		0.873
(1.00) 		0.0676
(0.706) 		0.323
(0.955) 		0.539
(0.999) 		0.759
(1.00) 		0.0846
(0.721) 		0.146
(0.833) 		0.617
(1.00) 		0.107
(0.784) 		0.873
(1.00) 		0.106
(0.78) 		0.906
(1.00) 		0.625
(1.00) 		0.422
(0.989) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		0.0296
(0.622) 		0.938
(1.00) 		0.407
(0.98) 		0.256
(0.912) 		0.895
(1.00) 		0.00756
(0.479) 		0.873
(1.00) 		0.778
(1.00) 		1
(1.00) 		0.0676
(0.706) 		0.385
(0.971) 		0.175
(0.845) 		0.623
(1.00) 		0.533
(0.999) 		0.878
(1.00) 		0.228
(0.901) 		0.196
(0.87) 		0.788
(1.00) 		0.688
(1.00)
16q gain 40 (14%) 252 0.849
(1.00) 		0.824
(1.00) 		0.0995
(0.761) 		0.647
(1.00) 		0.208
(0.876) 		0.721
(1.00) 		1
(1.00) 		0.819
(1.00) 		0.273
(0.918) 		0.291
(0.939) 		1
(1.00) 		0.277
(0.919) 		0.0671
(0.706) 		0.133
(0.801) 		0.337
(0.961) 		0.107
(0.784) 		0.819
(1.00) 		0.124
(0.795) 		0.613
(1.00) 		0.712
(1.00) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		0.0188
(0.58) 		0.762
(1.00) 		0.449
(0.993) 		0.0393
(0.629) 		0.894
(1.00) 		0.0281
(0.622) 		0.88
(1.00) 		0.789
(1.00) 		0.625
(1.00) 		0.273
(0.918) 		0.341
(0.962) 		0.25
(0.912) 		0.519
(0.998) 		1
(1.00) 		0.733
(1.00) 		0.681
(1.00) 		0.0232
(0.597) 		0.814
(1.00) 		0.0785
(0.721)
17p gain 22 (8%) 270 0.485
(0.997) 		0.17
(0.84) 		0.00263
(0.327) 		0.172
(0.84) 		0.238
(0.912) 		0.711
(1.00) 		0.261
(0.912) 		0.0776
(0.721) 		0.0429
(0.629) 		0.622
(1.00) 		0.362
(0.965) 		0.547
(0.999) 		1
(1.00) 		0.485
(0.997) 		0.518
(0.997) 		0.304
(0.943) 		0.0776
(0.721) 		0.327
(0.955) 		0.1
(0.761) 		0.997
(1.00) 		0.646
(1.00) 		1
(1.00) 		0.62
(1.00) 		0.415
(0.984) 		0.0122
(0.512) 		0.513
(0.997) 		0.48
(0.997) 		0.216
(0.888) 		0.116
(0.79) 		0.103
(0.773) 		0.517
(0.997) 		0.3
(0.943) 		0.494
(0.997) 		0.0429
(0.629) 		0.165
(0.84) 		0.451
(0.993) 		0.977
(1.00) 		0.651
(1.00) 		0.395
(0.974) 		0.608
(1.00) 		0.00434
(0.447) 		0.188
(0.858) 		0.162
(0.84)
17q gain 41 (14%) 251 0.679
(1.00) 		0.444
(0.993) 		0.0226
(0.597) 		0.621
(1.00) 		1
(1.00) 		0.208
(0.876) 		1
(1.00) 		0.0477
(0.65) 		0.193
(0.864) 		0.639
(1.00) 		0.332
(0.959) 		0.351
(0.962) 		1
(1.00) 		0.849
(1.00) 		0.0234
(0.597) 		0.59
(1.00) 		0.0477
(0.65) 		0.086
(0.721) 		0.466
(0.995) 		0.216
(0.889) 		0.877
(1.00) 		1
(1.00) 		0.798
(1.00) 		1
(1.00) 		0.00967
(0.497) 		0.374
(0.969) 		0.127
(0.799) 		0.0671
(0.706) 		0.255
(0.912) 		0.459
(0.993) 		0.642
(1.00) 		0.668
(1.00) 		0.473
(0.996) 		0.193
(0.864) 		0.665
(1.00) 		1
(1.00) 		0.515
(0.997) 		0.693
(1.00) 		0.0526
(0.668) 		0.272
(0.917) 		0.396
(0.974) 		0.00239
(0.312) 		0.486
(0.997) 		0.108
(0.784)
18p gain 48 (16%) 244 0.453
(0.993) 		0.0176
(0.558) 		0.0387
(0.627) 		0.25
(0.912) 		1
(1.00) 		0.0803
(0.721) 		1
(1.00) 		0.84
(1.00) 		0.394
(0.974) 		0.955
(1.00) 		0.343
(0.962) 		0.17
(0.84) 		0.327
(0.955) 		0.655
(1.00) 		0.128
(0.799) 		0.748
(1.00) 		0.84
(1.00) 		0.0969
(0.752) 		0.391
(0.974) 		0.0276
(0.618) 		0.699
(1.00) 		1
(1.00) 		0.903
(1.00) 		1
(1.00) 		0.0546
(0.668) 		0.149
(0.836) 		0.2
(0.875) 		0.0147
(0.529) 		0.881
(1.00) 		0.565
(0.999) 		0.437
(0.993) 		0.753
(1.00) 		1
(1.00) 		0.394
(0.974) 		0.593
(1.00) 		1
(1.00) 		0.197
(0.872) 		0.247
(0.912) 		0.528
(0.999) 		1
(1.00) 		0.61
(1.00) 		0.0776
(0.721) 		0.0216
(0.597) 		0.36
(0.964)
18q gain 31 (11%) 261 0.932
(1.00) 		0.0375
(0.627) 		0.0136
(0.523) 		1
(1.00) 		1
(1.00) 		0.272
(0.917) 		0.54
(0.999) 		0.747
(1.00) 		0.848
(1.00) 		0.545
(0.999) 		0.25
(0.912) 		0.292
(0.94) 		0.735
(1.00) 		0.889
(1.00) 		0.195
(0.869) 		0.876
(1.00) 		0.747
(1.00) 		0.0111
(0.503) 		0.274
(0.918) 		0.262
(0.912) 		0.1
(0.761) 		1
(1.00) 		0.841
(1.00) 		0.518
(0.997) 		0.0961
(0.752) 		0.486
(0.997) 		0.344
(0.962) 		0.0565
(0.668) 		0.886
(1.00) 		0.915
(1.00) 		0.274
(0.919) 		0.628
(1.00) 		0.557
(0.999) 		0.848
(1.00) 		0.719
(1.00) 		0.602
(1.00) 		0.292
(0.939) 		0.803
(1.00) 		0.561
(0.999) 		1
(1.00) 		0.61
(1.00) 		0.0387
(0.627) 		0.0434
(0.629) 		0.557
(0.999)
19p gain 44 (15%) 248 0.331
(0.958) 		0.666
(1.00) 		0.105
(0.78) 		0.122
(0.795) 		1
(1.00) 		0.454
(0.993) 		0.183
(0.85) 		0.217
(0.89) 		0.0959
(0.752) 		0.568
(1) 		0.207
(0.876) 		0.819
(1.00) 		0.327
(0.955) 		0.157
(0.84) 		0.853
(1.00) 		0.487
(0.997) 		0.217
(0.89) 		0.00565
(0.479) 		0.936
(1.00) 		0.692
(1.00) 		0.521
(0.998) 		0.53
(0.999) 		0.112
(0.787) 		1
(1.00) 		0.182
(0.849) 		0.882
(1.00) 		0.131
(0.801) 		0.0571
(0.668) 		0.765
(1.00) 		0.147
(0.835) 		0.826
(1.00) 		0.789
(1.00) 		0.105
(0.78) 		0.0959
(0.752) 		0.0801
(0.721) 		0.0325
(0.622) 		0.874
(1.00) 		1
(1.00) 		0.644
(1.00) 		0.214
(0.885) 		0.571
(1) 		0.334
(0.959) 		0.575
(1.00) 		0.278
(0.92)
19q gain 71 (24%) 221 0.58
(1.00) 		0.319
(0.955) 		0.0357
(0.627) 		0.453
(0.993) 		0.114
(0.787) 		0.329
(0.956) 		0.0433
(0.629) 		0.17
(0.84) 		0.576
(1.00) 		0.617
(1.00) 		0.0175
(0.558) 		0.651
(1.00) 		1
(1.00) 		0.117
(0.792) 		0.615
(1.00) 		0.12
(0.795) 		0.17
(0.84) 		0.0412
(0.629) 		0.651
(1.00) 		0.565
(0.999) 		0.27
(0.916) 		0.543
(0.999) 		0.205
(0.876) 		1
(1.00) 		0.0289
(0.622) 		0.55
(0.999) 		0.165
(0.84) 		0.00573
(0.479) 		0.463
(0.995) 		0.228
(0.901) 		0.939
(1.00) 		0.877
(1.00) 		0.163
(0.84) 		0.576
(1.00) 		0.603
(1.00) 		0.0776
(0.721) 		0.255
(0.912) 		0.552
(0.999) 		0.303
(0.943) 		1
(1.00) 		0.753
(1.00) 		0.312
(0.95) 		0.347
(0.962) 		0.159
(0.84)
20p gain 100 (34%) 192 0.637
(1.00) 		0.0838
(0.721) 		0.00523
(0.479) 		0.0829
(0.721) 		0.496
(0.997) 		0.728
(1.00) 		1
(1.00) 		0.514
(0.997) 		0.0124
(0.512) 		0.166
(0.84) 		0.342
(0.962) 		0.203
(0.875) 		1
(1.00) 		0.577
(1.00) 		0.348
(0.962) 		0.726
(1.00) 		0.514
(0.997) 		0.457
(0.993) 		0.803
(1.00) 		0.785
(1.00) 		0.704
(1.00) 		0.53
(0.999) 		0.336
(0.961) 		0.641
(1.00) 		0.288
(0.939) 		0.375
(0.969) 		0.484
(0.997) 		0.326
(0.955) 		0.741
(1.00) 		0.62
(1.00) 		0.854
(1.00) 		0.591
(1.00) 		0.597
(1.00) 		0.0124
(0.512) 		0.929
(1.00) 		0.581
(1.00) 		0.605
(1.00) 		0.742
(1.00) 		0.348
(0.962) 		1
(1.00) 		0.95
(1.00) 		0.0987
(0.756) 		0.0805
(0.721) 		0.831
(1.00)
20q gain 114 (39%) 178 0.228
(0.901) 		0.131
(0.801) 		0.0938
(0.751) 		0.739
(1.00) 		0.738
(1.00) 		0.717
(1.00) 		1
(1.00) 		0.96
(1.00) 		0.18
(0.849) 		0.107
(0.784) 		0.258
(0.912) 		0.162
(0.84) 		0.467
(0.996) 		0.285
(0.931) 		0.451
(0.993) 		0.92
(1.00) 		0.96
(1.00) 		0.344
(0.962) 		0.75
(1.00) 		0.926
(1.00) 		0.783
(1.00) 		0.543
(0.999) 		0.874
(1.00) 		1
(1.00) 		0.505
(0.997) 		0.461
(0.994) 		0.464
(0.995) 		0.972
(1.00) 		0.561
(0.999) 		0.234
(0.911) 		0.515
(0.997) 		0.632
(1.00) 		0.734
(1.00) 		0.18
(0.849) 		0.823
(1.00) 		0.278
(0.92) 		0.624
(1.00) 		0.604
(1.00) 		0.428
(0.992) 		1
(1.00) 		0.493
(0.997) 		0.215
(0.887) 		0.0883
(0.726) 		0.314
(0.95)
21q gain 37 (13%) 255 0.543
(0.999) 		0.0717
(0.721) 		0.27
(0.916) 		1
(1.00) 		0.615
(1.00) 		0.689
(1.00) 		0.559
(0.999) 		0.265
(0.912) 		0.834
(1.00) 		0.808
(1.00) 		0.731
(1.00) 		0.594
(1.00) 		0.189
(0.858) 		0.479
(0.997) 		0.445
(0.993) 		0.866
(1.00) 		0.265
(0.912) 		0.271
(0.917) 		0.421
(0.988) 		0.498
(0.997) 		0.627
(1.00) 		0.382
(0.97) 		1
(1.00) 		0.415
(0.984) 		0.668
(1.00) 		0.256
(0.912) 		0.932
(1.00) 		0.857
(1.00) 		0.554
(0.999) 		0.933
(1.00) 		0.374
(0.969) 		0.0601
(0.674) 		0.619
(1.00) 		0.834
(1.00) 		0.841
(1.00) 		0.0446
(0.635) 		0.493
(0.997) 		0.818
(1.00) 		0.606
(1.00) 		1
(1.00) 		0.712
(1.00) 		0.269
(0.914) 		0.0789
(0.721) 		0.385
(0.971)
22q gain 29 (10%) 263 0.159
(0.84) 		0.658
(1.00) 		0.697
(1.00) 		0.775
(1.00) 		1
(1.00) 		0.927
(1.00) 		0.517
(0.997) 		0.778
(1.00) 		0.551
(0.999) 		0.178
(0.846) 		1
(1.00) 		0.352
(0.963) 		0.552
(0.999) 		0.199
(0.874) 		0.615
(1.00) 		0.524
(0.998) 		0.778
(1.00) 		0.867
(1.00) 		0.348
(0.962) 		0.483
(0.997) 		0.485
(0.997) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		0.56
(0.999) 		0.559
(0.999) 		0.381
(0.97) 		0.725
(1.00) 		0.783
(1.00) 		0.915
(1.00) 		0.317
(0.953) 		0.957
(1.00) 		1
(1.00) 		0.551
(0.999) 		0.711
(1.00) 		0.553
(0.999) 		0.878
(1.00) 		0.281
(0.927) 		0.966
(1.00) 		0.593
(1.00) 		0.336
(0.961) 		0.163
(0.84) 		0.607
(1.00) 		0.691
(1.00)
xq gain 42 (14%) 250 0.0856
(0.721) 		0.822
(1.00) 		0.0299
(0.622) 		0.64
(1.00) 		1
(1.00) 		0.68
(1.00) 		0.592
(1.00) 		0.392
(0.974) 		0.944
(1.00) 		0.26
(0.912) 		0.0838
(0.721) 		0.321
(0.955) 		0.802
(1.00) 		0.807
(1.00) 		0.435
(0.993) 		0.0581
(0.67) 		0.392
(0.974) 		0.5
(0.997) 		0.581
(1.00) 		0.691
(1.00) 		0.949
(1.00) 		0.298
(0.941) 		1
(1.00) 		0.58
(1.00) 		0.174
(0.842) 		0.762
(1.00) 		0.242
(0.912) 		0.0195
(0.591) 		0.495
(0.997) 		0.622
(1.00) 		0.622
(1.00) 		0.425
(0.991) 		0.625
(1.00) 		0.944
(1.00) 		0.516
(0.997) 		0.455
(0.993) 		0.162
(0.84) 		0.0882
(0.726) 		0.35
(0.962) 		0.458
(0.993) 		0.341
(0.962) 		0.872
(1.00) 		0.826
(1.00)
1p loss 13 (4%) 279 0.429
(0.992) 		0.914
(1.00) 		0.115
(0.787) 		0.639
(1.00) 		0.0823
(0.721) 		0.825
(1.00) 		0.138
(0.811) 		0.919
(1.00) 		0.869
(1.00) 		0.911
(1.00) 		0.263
(0.912) 		0.403
(0.978) 		0.626
(1.00) 		0.855
(1.00) 		0.856
(1.00) 		0.919
(1.00) 		0.156
(0.84) 		0.744
(1.00) 		0.941
(1.00) 		0.0644
(0.702) 		1
(1.00) 		1
(1.00) 		0.296
(0.941) 		0.0673
(0.706) 		0.587
(1.00) 		0.195
(0.869) 		0.169
(0.84) 		0.208
(0.878) 		0.53
(0.999) 		1
(1.00) 		0.359
(0.964) 		0.869
(1.00) 		0.811
(1.00) 		0.0758
(0.721) 		0.0778
(0.721) 		0.382
(0.97) 		0.867
(1.00) 		1
(1.00) 		0.0213
(0.597) 		0.946
(1.00) 		0.414
(0.984)
1q loss 9 (3%) 283 0.5
(0.997) 		0.559
(0.999) 		0.388
(0.971) 		0.369
(0.969) 		0.304
(0.943) 		0.681
(1.00) 		0.008
(0.481) 		0.311
(0.95) 		0.255
(0.912) 		0.239
(0.912) 		1
(1.00) 		0.429
(0.992) 		0.667
(1.00) 		0.914
(1.00) 		0.834
(1.00) 		0.311
(0.95) 		0.113
(0.787) 		0.664
(1.00) 		0.524
(0.998) 		0.00337
(0.368) 		1
(1.00) 		0.242
(0.912) 		0.23
(0.901) 		0.0274
(0.618) 		0.548
(0.999) 		0.502
(0.997) 		0.238
(0.912) 		0.0542
(0.668) 		0.668
(1.00) 		1
(1.00) 		0.471
(0.996) 		0.676
(1.00) 		0.255
(0.912) 		0.124
(0.795) 		0.15
(0.836) 		0.0311
(0.622) 		0.219
(0.896) 		0.171
(0.84) 		1
(1.00) 		0.251
(0.912) 		0.534
(0.999) 		0.694
(1.00)
2p loss 19 (7%) 273 0.943
(1.00) 		0.452
(0.993) 		0.642
(1.00) 		0.516
(0.997) 		1
(1.00) 		0.829
(1.00) 		1
(1.00) 		0.977
(1.00) 		0.748
(1.00) 		0.641
(1.00) 		0.649
(1.00) 		0.424
(0.99) 		0.456
(0.993) 		0.552
(0.999) 		0.789
(1.00) 		0.977
(1.00) 		0.244
(0.912) 		0.894
(1.00) 		0.512
(0.997) 		0.935
(1.00) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		0.0322
(0.622) 		0.33
(0.958) 		0.112
(0.787) 		0.325
(0.955) 		0.0852
(0.721) 		0.202
(0.875) 		0.6
(1.00) 		1
(1.00) 		0.527
(0.999) 		0.748
(1.00) 		0.0172
(0.558) 		0.553
(0.999) 		0.605
(1.00) 		0.47
(0.996) 		0.928
(1.00) 		0.587
(1.00) 		0.874
(1.00) 		0.488
(0.997) 		0.535
(0.999)
2q loss 35 (12%) 257 0.782
(1.00) 		0.311
(0.95) 		0.73
(1.00) 		1
(1.00) 		0.354
(0.964) 		0.846
(1.00) 		0.379
(0.97) 		0.803
(1.00) 		0.726
(1.00) 		0.756
(1.00) 		0.743
(1.00) 		0.246
(0.912) 		0.167
(0.84) 		0.42
(0.986) 		0.567
(1) 		0.961
(1.00) 		0.803
(1.00) 		0.287
(0.938) 		0.872
(1.00) 		0.166
(0.84) 		0.555
(0.999) 		1
(1.00) 		0.505
(0.997) 		1
(1.00) 		0.0572
(0.668) 		0.762
(1.00) 		0.247
(0.912) 		0.367
(0.969) 		0.0575
(0.668) 		0.695
(1.00) 		0.651
(1.00) 		0.441
(0.993) 		0.465
(0.995) 		0.726
(1.00) 		0.00417
(0.443) 		1
(1.00) 		0.884
(1.00) 		1
(1.00) 		0.364
(0.967) 		0.207
(0.876) 		0.913
(1.00) 		0.347
(0.962) 		0.37
(0.969)
3q loss 14 (5%) 278 0.663
(1.00) 		0.398
(0.974) 		0.59
(1.00) 		0.433
(0.993) 		1
(1.00) 		0.4
(0.975) 		0.375
(0.969) 		0.0132
(0.512) 		0.791
(1.00) 		0.779
(1.00) 		1
(1.00) 		0.268
(0.914) 		0.626
(1.00) 		0.673
(1.00) 		0.617
(1.00) 		0.509
(0.997) 		0.0132
(0.512) 		0.509
(0.997) 		0.798
(1.00) 		0.295
(0.941) 		0.863
(1.00) 		1
(1.00) 		0.732
(1.00) 		0.684
(1.00) 		0.823
(1.00) 		0.586
(1.00) 		0.291
(0.939) 		0.381
(0.97) 		0.556
(0.999) 		0.367
(0.969) 		0.791
(1.00) 		0.621
(1.00) 		1
(1.00) 		0.692
(1.00) 		0.678
(1.00) 		0.0957
(0.752) 		0.402
(0.978) 		0.307
(0.948) 		0.414
(0.984) 		0.447
(0.993)
4q loss 90 (31%) 202 0.254
(0.912) 		0.428
(0.992) 		0.0573
(0.668) 		0.0295
(0.622) 		0.29
(0.939) 		0.16
(0.84) 		0.532
(0.999) 		0.663
(1.00) 		0.0125
(0.512) 		0.405
(0.978) 		0.225
(0.9) 		0.0558
(0.668) 		1
(1.00) 		0.442
(0.993) 		0.00126
(0.267) 		0.357
(0.964) 		0.663
(1.00) 		0.356
(0.964) 		0.405
(0.978) 		0.195
(0.869) 		0.743
(1.00) 		0.543
(0.999) 		0.134
(0.804) 		0.356
(0.964) 		0.472
(0.996) 		0.715
(1.00) 		0.404
(0.978) 		0.417
(0.985) 		0.141
(0.823) 		0.943
(1.00) 		0.322
(0.955) 		0.83
(1.00) 		0.349
(0.962) 		0.0125
(0.512) 		0.381
(0.97) 		0.579
(1.00) 		0.0785
(0.721) 		0.781
(1.00) 		0.949
(1.00) 		1
(1.00) 		0.157
(0.84) 		0.138
(0.811) 		0.455
(0.993) 		0.738
(1.00)
5p loss 19 (7%) 273 0.0428
(0.629) 		0.705
(1.00) 		0.0873
(0.723) 		0.0653
(0.705) 		1
(1.00) 		0.509
(0.997) 		0.0336
(0.627) 		0.167
(0.84) 		0.0364
(0.627) 		1
(1.00) 		1
(1.00) 		0.636
(1.00) 		0.0556
(0.668) 		0.752
(1.00) 		0.462
(0.994) 		0.167
(0.84) 		0.0544
(0.668) 		0.869
(1.00) 		0.762
(1.00) 		0.00759
(0.479) 		0.459
(0.993) 		0.311
(0.95) 		0.415
(0.984) 		0.0966
(0.752) 		0.48
(0.997) 		0.67
(1.00) 		0.679
(1.00) 		0.0147
(0.529) 		0.906
(1.00) 		0.855
(1.00) 		0.538
(0.999) 		0.167
(0.84) 		0.0364
(0.627) 		0.682
(1.00) 		0.302
(0.943) 		0.207
(0.876) 		0.731
(1.00) 		0.955
(1.00) 		1
(1.00) 		0.362
(0.965) 		0.741
(1.00) 		0.252
(0.912)
5q loss 51 (17%) 241 0.128
(0.799) 		0.181
(0.849) 		0.263
(0.912) 		0.679
(1.00) 		1
(1.00) 		0.572
(1) 		0.201
(0.875) 		0.309
(0.95) 		0.094
(0.751) 		0.691
(1.00) 		1
(1.00) 		0.22
(0.898) 		0.15
(0.836) 		0.318
(0.955) 		0.513
(0.997) 		0.054
(0.668) 		0.309
(0.95) 		0.16
(0.84) 		1
(1.00) 		0.805
(1.00) 		0.178
(0.846) 		1
(1.00) 		0.0323
(0.622) 		1
(1.00) 		0.768
(1.00) 		0.213
(0.885) 		0.301
(0.943) 		0.449
(0.993) 		0.0461
(0.642) 		0.748
(1.00) 		0.94
(1.00) 		0.659
(1.00) 		0.0585
(0.672) 		0.094
(0.751) 		0.827
(1.00) 		0.529
(0.999) 		0.327
(0.955) 		0.399
(0.975) 		0.446
(0.993) 		0.511
(0.997) 		0.0617
(0.681) 		0.615
(1.00) 		0.202
(0.875) 		0.181
(0.849)
6p loss 47 (16%) 245 0.334
(0.959) 		0.453
(0.993) 		0.178
(0.846) 		0.491
(0.997) 		0.208
(0.876) 		0.122
(0.795) 		0.19
(0.858) 		0.809
(1.00) 		0.498
(0.997) 		0.422
(0.989) 		0.745
(1.00) 		0.484
(0.997) 		0.626
(1.00) 		0.0238
(0.597) 		0.637
(1.00) 		0.173
(0.84) 		0.809
(1.00) 		0.971
(1.00) 		0.898
(1.00) 		0.845
(1.00) 		0.0832
(0.721) 		1
(1.00) 		1
(1.00) 		0.573
(1) 		0.127
(0.799) 		0.0271
(0.618) 		0.411
(0.983) 		0.24
(0.912) 		0.479
(0.997) 		1
(1.00) 		0.659
(1.00) 		0.385
(0.971) 		1
(1.00) 		0.498
(0.997) 		0.434
(0.993) 		0.341
(0.962) 		0.0844
(0.721) 		0.332
(0.959) 		0.481
(0.997) 		0.464
(0.995) 		0.572
(1) 		0.466
(0.995) 		0.985
(1.00)
6q loss 74 (25%) 218 0.0957
(0.752) 		0.956
(1.00) 		0.946
(1.00) 		0.444
(0.993) 		0.447
(0.993) 		0.126
(0.799) 		0.375
(0.969) 		0.144
(0.826) 		0.573
(1) 		0.168
(0.84) 		0.603
(1.00) 		0.595
(1.00) 		0.673
(1.00) 		0.172
(0.84) 		0.729
(1.00) 		0.0267
(0.617) 		0.144
(0.826) 		0.844
(1.00) 		0.323
(0.955) 		0.192
(0.863) 		0.807
(1.00) 		1
(1.00) 		0.925
(1.00) 		0.321
(0.955) 		0.296
(0.941) 		0.47
(0.996) 		0.678
(1.00) 		0.203
(0.875) 		0.775
(1.00) 		0.813
(1.00) 		1
(1.00) 		0.545
(0.999) 		1
(1.00) 		0.573
(1) 		0.758
(1.00) 		0.688
(1.00) 		0.0588
(0.673) 		0.921
(1.00) 		0.264
(0.912) 		1
(1.00) 		0.685
(1.00) 		0.999
(1.00) 		0.782
(1.00)
7p loss 26 (9%) 266 0.397
(0.974) 		0.0886
(0.726) 		0.363
(0.965) 		0.775
(1.00) 		0.598
(1.00) 		0.388
(0.971) 		0.00208
(0.3) 		0.0795
(0.721) 		0.437
(0.993) 		0.128
(0.799) 		0.0823
(0.721) 		0.0349
(0.627) 		0.138
(0.811) 		0.515
(0.997) 		0.304
(0.943) 		0.642
(1.00) 		0.0795
(0.721) 		0.319
(0.955) 		0.862
(1.00) 		0.449
(0.993) 		0.0355
(0.627) 		1
(1.00) 		0.226
(0.9) 		1
(1.00) 		0.32
(0.955) 		0.374
(0.969) 		0.351
(0.962) 		0.284
(0.931) 		0.251
(0.912) 		0.755
(1.00) 		0.26
(0.912) 		0.49
(0.997) 		0.78
(1.00) 		0.437
(0.993) 		0.435
(0.993) 		0.376
(0.969) 		0.708
(1.00) 		0.258
(0.912) 		0.8
(1.00) 		0.687
(1.00) 		0.398
(0.975) 		0.0984
(0.756) 		0.505
(0.997)
8q loss 24 (8%) 268 0.634
(1.00) 		0.402
(0.978) 		0.606
(1.00) 		0.238
(0.912) 		0.6
(1.00) 		0.0953
(0.752) 		0.0251
(0.613) 		0.862
(1.00) 		0.289
(0.939) 		0.181
(0.849) 		1
(1.00) 		0.93
(1.00) 		0.535
(0.999) 		0.057
(0.668) 		0.57
(1) 		0.862
(1.00) 		1
(1.00) 		0.835
(1.00) 		0.912
(1.00) 		0.304
(0.943) 		1
(1.00) 		0.627
(1.00) 		0.468
(0.996) 		0.81
(1.00) 		0.451
(0.993) 		0.951
(1.00) 		0.668
(1.00) 		0.639
(1.00) 		0.278
(0.92) 		0.765
(1.00) 		0.806
(1.00) 		0.394
(0.974) 		0.289
(0.939) 		0.726
(1.00) 		0.00729
(0.479) 		0.353
(0.964) 		0.0681
(0.708) 		0.47
(0.996) 		1
(1.00) 		0.298
(0.941) 		0.372
(0.969) 		0.177
(0.846)
9p loss 53 (18%) 239 0.639
(1.00) 		0.0109
(0.503) 		0.237
(0.912) 		0.809
(1.00) 		0.395
(0.974) 		0.929
(1.00) 		0.803
(1.00) 		0.744
(1.00) 		0.847
(1.00) 		0.609
(1.00) 		0.381
(0.97) 		0.261
(0.912) 		0.503
(0.997) 		0.196
(0.871) 		0.727
(1.00) 		0.289
(0.939) 		0.744
(1.00) 		0.391
(0.974) 		0.99
(1.00) 		0.979
(1.00) 		0.499
(0.997) 		1
(1.00) 		0.631
(1.00) 		1
(1.00) 		0.0676
(0.706) 		0.331
(0.958) 		0.66
(1.00) 		0.377
(0.969) 		0.0166
(0.558) 		0.246
(0.912) 		0.853
(1.00) 		0.247
(0.912) 		0.625
(1.00) 		0.847
(1.00) 		0.0754
(0.721) 		0.51
(0.997) 		0.942
(1.00) 		0.448
(0.993) 		0.542
(0.999) 		0.713
(1.00) 		0.306
(0.948) 		0.00762
(0.479) 		0.0775
(0.721)
9q loss 50 (17%) 242 0.417
(0.985) 		0.00608
(0.479) 		0.115
(0.787) 		0.468
(0.996) 		0.41
(0.982) 		0.663
(1.00) 		0.798
(1.00) 		0.642
(1.00) 		0.642
(1.00) 		0.343
(0.962) 		1
(1.00) 		0.884
(1.00) 		0.112
(0.787) 		0.101
(0.761) 		0.852
(1.00) 		0.398
(0.974) 		0.642
(1.00) 		0.377
(0.969) 		0.863
(1.00) 		0.438
(0.993) 		0.672
(1.00) 		1
(1.00) 		0.431
(0.992) 		1
(1.00) 		0.0416
(0.629) 		0.311
(0.95) 		0.676
(1.00) 		0.225
(0.9) 		0.0357
(0.627) 		0.301
(0.943) 		1
(1.00) 		0.182
(0.849) 		0.639
(1.00) 		0.642
(1.00) 		0.438
(0.993) 		0.343
(0.962) 		0.239
(0.912) 		0.511
(0.997) 		0.216
(0.888) 		1
(1.00) 		0.389
(0.971) 		0.00682
(0.479) 		0.436
(0.993)
10p loss 66 (23%) 226 0.363
(0.966) 		0.0756
(0.721) 		0.0806
(0.721) 		0.0457
(0.642) 		0.685
(1.00) 		0.718
(1.00) 		0.0648
(0.702) 		0.944
(1.00) 		0.0175
(0.558) 		0.157
(0.84) 		0.788
(1.00) 		0.611
(1.00) 		0.526
(0.999) 		0.314
(0.95) 		0.0144
(0.529) 		0.586
(1.00) 		0.944
(1.00) 		0.0111
(0.503) 		0.46
(0.993) 		0.833
(1.00) 		0.278
(0.92) 		1
(1.00) 		0.457
(0.993) 		1
(1.00) 		0.205
(0.876) 		0.55
(0.999) 		0.36
(0.964) 		0.0977
(0.753) 		0.348
(0.962) 		0.296
(0.941) 		0.0435
(0.629) 		0.338
(0.962) 		0.0378
(0.627) 		0.0175
(0.558) 		0.336
(0.961) 		0.0662
(0.706) 		0.145
(0.83) 		0.872
(1.00) 		0.111
(0.787) 		0.511
(0.997) 		0.262
(0.912) 		0.0173
(0.558) 		0.083
(0.721) 		0.0756
(0.721)
12p loss 40 (14%) 252 0.359
(0.964) 		0.901
(1.00) 		0.581
(1.00) 		1
(1.00) 		0.357
(0.964) 		0.824
(1.00) 		1
(1.00) 		0.263
(0.912) 		0.875
(1.00) 		0.679
(1.00) 		0.317
(0.954) 		0.535
(0.999) 		0.327
(0.955) 		0.834
(1.00) 		0.102
(0.767) 		0.71
(1.00) 		0.263
(0.912) 		0.14
(0.819) 		0.394
(0.974) 		0.976
(1.00) 		0.676
(1.00) 		1
(1.00) 		0.453
(0.993) 		0.563
(0.999) 		0.114
(0.787) 		0.275
(0.919) 		0.521
(0.998) 		0.107
(0.784) 		0.993
(1.00) 		0.465
(0.995) 		0.813
(1.00) 		0.49
(0.997) 		1
(1.00) 		0.875
(1.00) 		0.313
(0.95) 		0.602
(1.00) 		0.414
(0.984) 		0.43
(0.992) 		0.0445
(0.635) 		0.121
(0.795) 		0.327
(0.955) 		0.892
(1.00) 		0.182
(0.849)
12q loss 15 (5%) 277 0.989
(1.00) 		0.0488
(0.655) 		0.0209
(0.597) 		0.369
(0.969) 		1
(1.00) 		0.298
(0.941) 		0.191
(0.859) 		0.138
(0.811) 		0.202
(0.875) 		0.532
(0.999) 		0.616
(1.00) 		0.13
(0.801) 		0.667
(1.00) 		1
(1.00) 		0.497
(0.997) 		0.138
(0.811) 		0.813
(1.00) 		0.666
(1.00) 		0.395
(0.974) 		0.303
(0.943) 		1
(1.00) 		0.392
(0.974) 		1
(1.00) 		0.115
(0.787) 		0.548
(0.999) 		0.678
(1.00) 		0.178
(0.846) 		0.596
(1.00) 		0.385
(0.971) 		1
(1.00) 		0.0808
(0.721) 		1
(1.00) 		0.202
(0.875) 		0.932
(1.00) 		0.36
(0.964) 		0.174
(0.843) 		0.782
(1.00) 		0.0802
(0.721) 		1
(1.00) 		0.0221
(0.597) 		0.0527
(0.668) 		0.0359
(0.627)
13q loss 79 (27%) 213 0.734
(1.00) 		0.239
(0.912) 		0.0907
(0.742) 		0.0605
(0.674) 		0.465
(0.995) 		0.00179
(0.294) 		0.395
(0.974) 		0.415
(0.984) 		0.0131
(0.512) 		0.738
(1.00) 		0.202
(0.875) 		0.751
(1.00) 		0.534
(0.999) 		0.523
(0.998) 		0.124
(0.795) 		0.115
(0.787) 		0.415
(0.984) 		0.0345
(0.627) 		0.0324
(0.622) 		0.434
(0.993) 		0.113
(0.787) 		0.53
(0.999) 		0.547
(0.999) 		1
(1.00) 		0.124
(0.795) 		0.795
(1.00) 		0.963
(1.00) 		0.0502
(0.656) 		0.599
(1.00) 		0.384
(0.971) 		0.871
(1.00) 		0.859
(1.00) 		0.0125
(0.512) 		0.0131
(0.512) 		0.657
(1.00) 		1
(1.00) 		0.0257
(0.613) 		0.814
(1.00) 		0.808
(1.00) 		0.0421
(0.629) 		0.265
(0.912) 		0.173
(0.84) 		0.0595
(0.674)
14q loss 35 (12%) 257 0.679
(1.00) 		0.0103
(0.503) 		0.564
(0.999) 		1
(1.00) 		0.354
(0.964) 		0.406
(0.98) 		0.148
(0.836) 		0.0359
(0.627) 		0.669
(1.00) 		0.51
(0.997) 		1
(1.00) 		0.376
(0.969) 		0.25
(0.912) 		0.376
(0.969) 		0.0361
(0.627) 		0.949
(1.00) 		0.0359
(0.627) 		0.645
(1.00) 		0.89
(1.00) 		0.0328
(0.622) 		0.276
(0.919) 		1
(1.00) 		0.541
(0.999) 		0.518
(0.997) 		0.386
(0.971) 		0.48
(0.997) 		0.615
(1.00) 		0.761
(1.00) 		0.0972
(0.752) 		0.906
(1.00) 		1
(1.00) 		0.0406
(0.629) 		1
(1.00) 		0.669
(1.00) 		0.647
(1.00) 		0.436
(0.993) 		0.955
(1.00) 		0.12
(0.794) 		0.125
(0.795) 		0.681
(1.00) 		0.231
(0.906) 		0.0112
(0.503) 		0.886
(1.00)
15q loss 46 (16%) 246 0.57
(1) 		0.00898
(0.483) 		0.0523
(0.668) 		0.348
(0.962) 		0.118
(0.792) 		0.507
(0.997) 		1
(1.00) 		0.376
(0.969) 		0.997
(1.00) 		0.0329
(0.622) 		0.539
(0.999) 		0.981
(1.00) 		0.813
(1.00) 		0.246
(0.912) 		0.0107
(0.503) 		0.0814
(0.721) 		0.376
(0.969) 		0.798
(1.00) 		0.402
(0.978) 		0.713
(1.00) 		0.683
(1.00) 		1
(1.00) 		0.248
(0.912) 		1
(1.00) 		0.895
(1.00) 		0.698
(1.00) 		0.0804
(0.721) 		0.638
(1.00) 		0.558
(0.999) 		0.526
(0.999) 		1
(1.00) 		0.121
(0.795) 		1
(1.00) 		0.997
(1.00) 		0.91
(1.00) 		1
(1.00) 		0.848
(1.00) 		0.839
(1.00) 		0.901
(1.00) 		1
(1.00) 		1
(1.00) 		0.0771
(0.721) 		0.00946
(0.495) 		0.0987
(0.756)
16p loss 34 (12%) 258 0.231
(0.906) 		0.0745
(0.721) 		0.0497
(0.655) 		0.0399
(0.629) 		0.182
(0.849) 		0.162
(0.84) 		0.764
(1.00) 		0.777
(1.00) 		0.323
(0.955) 		0.96
(1.00) 		0.476
(0.997) 		0.577
(1.00) 		0.366
(0.969) 		0.843
(1.00) 		0.1
(0.761) 		0.724
(1.00) 		0.777
(1.00) 		0.276
(0.919) 		0.983
(1.00) 		0.433
(0.993) 		0.571
(1) 		1
(1.00) 		0.313
(0.95) 		0.358
(0.964) 		0.465
(0.995) 		0.559
(0.999) 		1
(1.00) 		0.927
(1.00) 		0.487
(0.997) 		0.915
(1.00) 		0.563
(0.999) 		0.47
(0.996) 		0.588
(1.00) 		0.323
(0.955) 		0.69
(1.00) 		0.0446
(0.635) 		0.109
(0.787) 		0.926
(1.00) 		0.857
(1.00) 		1
(1.00) 		0.34
(0.962) 		0.0401
(0.629) 		0.689
(1.00)
17p loss 95 (33%) 197 0.385
(0.971) 		0.0716
(0.721) 		0.926
(1.00) 		1
(1.00) 		0.721
(1.00) 		0.324
(0.955) 		0.681
(1.00) 		0.569
(1) 		0.586
(1.00) 		0.229
(0.901) 		0.241
(0.912) 		0.169
(0.84) 		0.122
(0.795) 		0.451
(0.993) 		0.0374
(0.627) 		0.716
(1.00) 		0.569
(1) 		0.388
(0.971) 		0.327
(0.955) 		0.954
(1.00) 		0.922
(1.00) 		1
(1.00) 		0.432
(0.993) 		1
(1.00) 		0.484
(0.997) 		0.479
(0.997) 		0.36
(0.964) 		0.48
(0.997) 		0.17
(0.84) 		0.666
(1.00) 		0.764
(1.00) 		0.83
(1.00) 		1
(1.00) 		0.586
(1.00) 		0.506
(0.997) 		0.29
(0.939) 		0.294
(0.941) 		0.293
(0.94) 		0.571
(1) 		0.58
(1.00) 		0.429
(0.992) 		0.703
(1.00) 		0.0842
(0.721) 		0.777
(1.00)
17q loss 37 (13%) 255 0.684
(1.00) 		0.00721
(0.479) 		0.674
(1.00) 		0.802
(1.00) 		0.595
(1.00) 		0.178
(0.846) 		0.559
(0.999) 		0.573
(1) 		0.642
(1.00) 		0.216
(0.888) 		0.319
(0.955) 		0.814
(1.00) 		0.776
(1.00) 		0.502
(0.997) 		0.663
(1.00) 		0.129
(0.8) 		0.573
(1) 		0.078
(0.721) 		0.672
(1.00) 		0.374
(0.969) 		0.706
(1.00) 		1
(1.00) 		0.893
(1.00) 		1
(1.00) 		0.922
(1.00) 		0.331
(0.958) 		0.304
(0.943) 		0.981
(1.00) 		0.43
(0.992) 		0.565
(0.999) 		0.358
(0.964) 		0.338
(0.962) 		0.602
(1.00) 		0.642
(1.00) 		0.937
(1.00) 		0.341
(0.962) 		0.0382
(0.627) 		0.875
(1.00) 		0.094
(0.751) 		0.357
(0.964) 		1
(1.00) 		0.409
(0.982) 		0.00812
(0.481) 		0.461
(0.994)
18p loss 55 (19%) 237 0.587
(1.00) 		0.49
(0.997) 		0.934
(1.00) 		1
(1.00) 		1
(1.00) 		0.00541
(0.479) 		0.135
(0.806) 		0.143
(0.826) 		0.455
(0.993) 		0.953
(1.00) 		1
(1.00) 		0.548
(0.999) 		0.662
(1.00) 		0.984
(1.00) 		0.396
(0.974) 		0.478
(0.997) 		0.143
(0.826) 		0.394
(0.974) 		0.946
(1.00) 		0.512
(0.997) 		0.263
(0.912) 		0.536
(0.999) 		0.616
(1.00) 		1
(1.00) 		0.681
(1.00) 		0.213
(0.885) 		0.562
(0.999) 		0.557
(0.999) 		0.295
(0.941) 		0.804
(1.00) 		0.652
(1.00) 		0.859
(1.00) 		0.0736
(0.721) 		0.455
(0.993) 		0.504
(0.997) 		0.809
(1.00) 		0.161
(0.84) 		0.0374
(0.627) 		0.0684
(0.709) 		0.0686
(0.709) 		0.67
(1.00) 		0.442
(0.993) 		0.464
(0.995)
19q loss 29 (10%) 263 0.114
(0.787) 		0.224
(0.9) 		0.477
(0.997) 		0.234
(0.911) 		0.566
(1) 		0.173
(0.84) 		0.198
(0.873) 		0.25
(0.912) 		0.588
(1.00) 		0.412
(0.984) 		1
(1.00) 		0.795
(1.00) 		0.348
(0.962) 		0.83
(1.00) 		0.296
(0.941) 		0.509
(0.997) 		0.25
(0.912) 		0.891
(1.00) 		0.184
(0.851) 		0.236
(0.912) 		0.284
(0.931) 		1
(1.00) 		0.697
(1.00) 		1
(1.00) 		0.493
(0.997) 		0.374
(0.969) 		0.981
(1.00) 		0.702
(1.00) 		0.431
(0.992) 		0.755
(1.00) 		0.872
(1.00) 		0.0374
(0.627) 		0.269
(0.914) 		0.588
(1.00) 		0.65
(1.00) 		0.722
(1.00) 		0.225
(0.9) 		0.912
(1.00) 		0.229
(0.901) 		0.687
(1.00) 		0.659
(1.00) 		0.804
(1.00) 		0.244
(0.912) 		0.472
(0.996)
20p loss 22 (8%) 270 0.496
(0.997) 		0.0256
(0.613) 		0.965
(1.00) 		1
(1.00) 		1
(1.00) 		0.553
(0.999) 		0.712
(1.00) 		0.0868
(0.722) 		0.821
(1.00) 		0.386
(0.971) 		0.668
(1.00) 		0.0481
(0.65) 		1
(1.00) 		0.741
(1.00) 		0.851
(1.00) 		0.436
(0.993) 		0.0868
(0.722) 		0.0461
(0.642) 		0.64
(1.00) 		0.703
(1.00) 		0.267
(0.914) 		0.107
(0.784) 		0.518
(0.997) 		0.358
(0.964) 		0.718
(1.00) 		0.36
(0.964) 		0.0786
(0.721) 		0.957
(1.00) 		0.857
(1.00) 		0.906
(1.00) 		1
(1.00) 		0.852
(1.00) 		0.761
(1.00) 		0.821
(1.00) 		0.877
(1.00) 		1
(1.00) 		0.929
(1.00) 		0.158
(0.84) 		0.729
(1.00) 		1
(1.00) 		0.758
(1.00) 		0.0677
(0.706) 		0.979
(1.00)
21q loss 49 (17%) 243 0.15
(0.836) 		0.473
(0.996) 		0.117
(0.792) 		1
(1.00) 		1
(1.00) 		0.728
(1.00) 		0.797
(1.00) 		0.537
(0.999) 		0.568
(1) 		0.116
(0.79) 		0.132
(0.801) 		0.0495
(0.655) 		0.641
(1.00) 		0.144
(0.826) 		0.00911
(0.483) 		0.537
(0.999) 		0.056
(0.668) 		0.00784
(0.479) 		0.916
(1.00) 		0.00726
(0.479) 		0.382
(0.97) 		0.0745
(0.721) 		0.309
(0.95) 		0.0204
(0.597) 		0.374
(0.969) 		0.735
(1.00) 		0.0368
(0.627) 		0.0355
(0.627) 		0.526
(0.999) 		0.559
(0.999) 		0.893
(1.00) 		0.822
(1.00) 		0.568
(1) 		0.185
(0.851) 		0.818
(1.00) 		0.228
(0.901) 		0.0968
(0.752) 		0.275
(0.919) 		0.492
(0.997) 		0.0777
(0.721) 		0.492
(0.997) 		0.228
(0.901)
22q loss 70 (24%) 222 0.281
(0.927) 		0.556
(0.999) 		0.424
(0.99) 		0.708
(1.00) 		0.722
(1.00) 		0.991
(1.00) 		0.257
(0.912) 		0.78
(1.00) 		0.437
(0.993) 		0.556
(0.999) 		0.791
(1.00) 		0.524
(0.998) 		0.4
(0.976) 		0.382
(0.97) 		0.826
(1.00) 		0.00448
(0.449) 		0.78
(1.00) 		0.228
(0.901) 		0.358
(0.964) 		0.331
(0.959) 		0.761
(1.00) 		0.53
(0.999) 		0.242
(0.912) 		0.612
(1.00) 		0.145
(0.83) 		0.187
(0.858) 		0.166
(0.84) 		0.447
(0.993) 		0.255
(0.912) 		0.879
(1.00) 		0.852
(1.00) 		0.108
(0.784) 		0.349
(0.962) 		0.437
(0.993) 		0.38
(0.97) 		0.323
(0.955) 		0.0856
(0.721) 		0.677
(1.00) 		0.173
(0.84) 		0.551
(0.999) 		0.659
(1.00) 		0.348
(0.962) 		0.59
(1.00) 		0.395
(0.974)
xp loss 62 (21%) 230 0.991
(1.00) 		0.212
(0.885) 		0.509
(0.997) 		0.559
(0.999) 		0.363
(0.965) 		0.0936
(0.751) 		0.239
(0.912) 		0.58
(1.00) 		0.98
(1.00) 		0.0607
(0.674) 		0.418
(0.985) 		0.5
(0.997) 		1
(1.00) 		0.728
(1.00) 		0.592
(1.00) 		0.591
(1.00) 		0.58
(1.00) 		0.379
(0.97) 		0.936
(1.00) 		0.589
(1.00) 		0.599
(1.00) 		0.188
(0.858) 		0.101
(0.762) 		1
(1.00) 		0.0434
(0.629) 		0.213
(0.885) 		0.165
(0.84) 		0.0089
(0.483) 		0.536
(0.999) 		0.744
(1.00) 		0.114
(0.787) 		0.276
(0.919) 		0.839
(1.00) 		0.98
(1.00) 		0.445
(0.993) 		0.0183
(0.569) 		0.0234
(0.597) 		0.38
(0.97) 		0.0848
(0.721) 		0.515
(0.997) 		0.462
(0.994) 		0.71
(1.00) 		0.179
(0.849) 		0.597
(1.00)
xq loss 58 (20%) 234 0.0538
(0.668) 		0.268
(0.914) 		0.608
(1.00) 		0.844
(1.00) 		0.651
(1.00) 		0.373
(0.969) 		0.15
(0.836) 		0.777
(1.00) 		0.777
(1.00) 		0.177
(0.846) 		0.601
(1.00) 		0.676
(1.00) 		0.372
(0.969) 		0.85
(1.00) 		0.76
(1.00) 		0.676
(1.00) 		0.777
(1.00) 		0.991
(1.00) 		0.74
(1.00) 		0.948
(1.00) 		0.326
(0.955) 		0.188
(0.858) 		0.203
(0.875) 		1
(1.00) 		0.205
(0.876) 		0.594
(1.00) 		0.19
(0.858) 		0.0283
(0.622) 		0.639
(1.00) 		0.489
(0.997) 		0.0263
(0.617) 		0.304
(0.943) 		1
(1.00) 		0.777
(1.00) 		0.978
(1.00) 		0.00655
(0.479) 		0.362
(0.965) 		0.846
(1.00) 		0.459
(0.993) 		0.518
(0.997) 		0.635
(1.00) 		0.676
(1.00) 		0.234
(0.911) 		0.419
(0.985)
'9q gain' versus 'PREGNANCIES_COUNT_LIVE_BIRTH'

P value = 0.00103 (Wilcoxon-test), Q value = 0.23

Table S1.  Gene #18: '9q gain' versus Clinical Feature #28: 'PREGNANCIES_COUNT_LIVE_BIRTH'

nPatients Mean (Std.Dev)
ALL 249 2.8 (2.0)
9Q GAIN MUTATED 38 3.6 (1.9)
9Q GAIN WILD-TYPE 211 2.7 (2.0)

Figure S1.  Get High-res Image Gene #18: '9q gain' versus Clinical Feature #28: 'PREGNANCIES_COUNT_LIVE_BIRTH'

'xp gain' versus 'PREGNANCIES_COUNT_LIVE_BIRTH'

P value = 0.000959 (Wilcoxon-test), Q value = 0.23

Table S2.  Gene #40: 'xp gain' versus Clinical Feature #28: 'PREGNANCIES_COUNT_LIVE_BIRTH'

nPatients Mean (Std.Dev)
ALL 249 2.8 (2.0)
XP GAIN MUTATED 39 3.9 (2.5)
XP GAIN WILD-TYPE 210 2.6 (1.9)

Figure S2.  Get High-res Image Gene #40: 'xp gain' versus Clinical Feature #28: 'PREGNANCIES_COUNT_LIVE_BIRTH'

'3p loss' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000729 (Wilcoxon-test), Q value = 0.21

Table S3.  Gene #46: '3p loss' versus Clinical Feature #9: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 148 0.9 (2.1)
3P LOSS MUTATED 41 1.3 (1.8)
3P LOSS WILD-TYPE 107 0.8 (2.1)

Figure S3.  Get High-res Image Gene #46: '3p loss' versus Clinical Feature #9: 'NUMBER_OF_LYMPH_NODES'

'3p loss' versus 'LYMPH_NODES_EXAMINED_HE_COUNT'

P value = 0.000729 (Wilcoxon-test), Q value = 0.21

Table S4.  Gene #46: '3p loss' versus Clinical Feature #34: 'LYMPH_NODES_EXAMINED_HE_COUNT'

nPatients Mean (Std.Dev)
ALL 148 0.9 (2.1)
3P LOSS MUTATED 41 1.3 (1.8)
3P LOSS WILD-TYPE 107 0.8 (2.1)

Figure S4.  Get High-res Image Gene #46: '3p loss' versus Clinical Feature #34: 'LYMPH_NODES_EXAMINED_HE_COUNT'

'4p loss' versus 'HISTOLOGICAL_TYPE'

P value = 0.00093 (Fisher's exact test), Q value = 0.23

Table S5.  Gene #48: '4p loss' versus Clinical Feature #6: 'HISTOLOGICAL_TYPE'

nPatients ADENOSQUAMOUS CERVICAL SQUAMOUS CELL CARCINOMA ENDOCERVICAL ADENOCARCINOMA OF THE USUAL TYPE ENDOCERVICAL TYPE OF ADENOCARCINOMA ENDOMETRIOID ADENOCARCINOMA OF ENDOCERVIX MUCINOUS ADENOCARCINOMA OF ENDOCERVICAL TYPE
ALL 5 241 6 22 3 15
4P LOSS MUTATED 2 118 3 2 0 4
4P LOSS WILD-TYPE 3 123 3 20 3 11

Figure S5.  Get High-res Image Gene #48: '4p loss' versus Clinical Feature #6: 'HISTOLOGICAL_TYPE'

'7q loss' versus 'RADIATIONS_RADIATION_REGIMENINDICATION'

P value = 0.000305 (Fisher's exact test), Q value = 0.18

Table S6.  Gene #55: '7q loss' versus Clinical Feature #7: 'RADIATIONS_RADIATION_REGIMENINDICATION'

nPatients NO YES
ALL 30 262
7Q LOSS MUTATED 11 26
7Q LOSS WILD-TYPE 19 236

Figure S6.  Get High-res Image Gene #55: '7q loss' versus Clinical Feature #7: 'RADIATIONS_RADIATION_REGIMENINDICATION'

'8p loss' versus 'TOBACCO_SMOKING_YEAR_STOPPED'

P value = 0.000769 (Wilcoxon-test), Q value = 0.21

Table S7.  Gene #56: '8p loss' versus Clinical Feature #16: 'TOBACCO_SMOKING_YEAR_STOPPED'

nPatients Mean (Std.Dev)
ALL 42 1999.7 (13.8)
8P LOSS MUTATED 12 2009.2 (4.3)
8P LOSS WILD-TYPE 30 1995.9 (14.5)

Figure S7.  Get High-res Image Gene #56: '8p loss' versus Clinical Feature #16: 'TOBACCO_SMOKING_YEAR_STOPPED'

'10q loss' versus 'NEOPLASM_HISTOLOGIC_GRADE'

P value = 0.00036 (Fisher's exact test), Q value = 0.19

Table S8.  Gene #61: '10q loss' versus Clinical Feature #15: 'NEOPLASM_HISTOLOGIC_GRADE'

nPatients G1 G2 G3 G4 GX
ALL 18 129 113 1 24
10Q LOSS MUTATED 3 20 43 1 7
10Q LOSS WILD-TYPE 15 109 70 0 17

Figure S8.  Get High-res Image Gene #61: '10q loss' versus Clinical Feature #15: 'NEOPLASM_HISTOLOGIC_GRADE'

'11p loss' versus 'YEARS_TO_BIRTH'

P value = 0.000658 (Wilcoxon-test), Q value = 0.21

Table S9.  Gene #62: '11p loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 288 48.0 (13.8)
11P LOSS MUTATED 98 52.1 (14.0)
11P LOSS WILD-TYPE 190 46.0 (13.3)

Figure S9.  Get High-res Image Gene #62: '11p loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'11p loss' versus 'AGE_AT_DIAGNOSIS'

P value = 0.000644 (Wilcoxon-test), Q value = 0.21

Table S10.  Gene #62: '11p loss' versus Clinical Feature #43: 'AGE_AT_DIAGNOSIS'

nPatients Mean (Std.Dev)
ALL 292 48.1 (13.8)
11P LOSS MUTATED 99 52.2 (13.9)
11P LOSS WILD-TYPE 193 46.1 (13.3)

Figure S10.  Get High-res Image Gene #62: '11p loss' versus Clinical Feature #43: 'AGE_AT_DIAGNOSIS'

'11q loss' versus 'YEARS_TO_BIRTH'

P value = 0.000131 (Wilcoxon-test), Q value = 0.18

Table S11.  Gene #63: '11q loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 288 48.0 (13.8)
11Q LOSS MUTATED 113 52.0 (13.8)
11Q LOSS WILD-TYPE 175 45.5 (13.2)

Figure S11.  Get High-res Image Gene #63: '11q loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'11q loss' versus 'AGE_AT_DIAGNOSIS'

P value = 0.000201 (Wilcoxon-test), Q value = 0.18

Table S12.  Gene #63: '11q loss' versus Clinical Feature #43: 'AGE_AT_DIAGNOSIS'

nPatients Mean (Std.Dev)
ALL 292 48.1 (13.8)
11Q LOSS MUTATED 114 52.0 (13.8)
11Q LOSS WILD-TYPE 178 45.6 (13.2)

Figure S12.  Get High-res Image Gene #63: '11q loss' versus Clinical Feature #43: 'AGE_AT_DIAGNOSIS'

'16q loss' versus 'HISTOLOGICAL_TYPE'

P value = 6e-05 (Fisher's exact test), Q value = 0.18

Table S13.  Gene #70: '16q loss' versus Clinical Feature #6: 'HISTOLOGICAL_TYPE'

nPatients ADENOSQUAMOUS CERVICAL SQUAMOUS CELL CARCINOMA ENDOCERVICAL ADENOCARCINOMA OF THE USUAL TYPE ENDOCERVICAL TYPE OF ADENOCARCINOMA ENDOMETRIOID ADENOCARCINOMA OF ENDOCERVIX MUCINOUS ADENOCARCINOMA OF ENDOCERVICAL TYPE
ALL 5 241 6 22 3 15
16Q LOSS MUTATED 0 26 4 9 1 4
16Q LOSS WILD-TYPE 5 215 2 13 2 11

Figure S13.  Get High-res Image Gene #70: '16q loss' versus Clinical Feature #6: 'HISTOLOGICAL_TYPE'

'18q loss' versus 'HISTOLOGICAL_TYPE'

P value = 0.00019 (Fisher's exact test), Q value = 0.18

Table S14.  Gene #74: '18q loss' versus Clinical Feature #6: 'HISTOLOGICAL_TYPE'

nPatients ADENOSQUAMOUS CERVICAL SQUAMOUS CELL CARCINOMA ENDOCERVICAL ADENOCARCINOMA OF THE USUAL TYPE ENDOCERVICAL TYPE OF ADENOCARCINOMA ENDOMETRIOID ADENOCARCINOMA OF ENDOCERVIX MUCINOUS ADENOCARCINOMA OF ENDOCERVICAL TYPE
ALL 5 241 6 22 3 15
18Q LOSS MUTATED 0 50 1 12 2 8
18Q LOSS WILD-TYPE 5 191 5 10 1 7

Figure S14.  Get High-res Image Gene #74: '18q loss' versus Clinical Feature #6: 'HISTOLOGICAL_TYPE'

'19p loss' versus 'Time to Death'

P value = 0.00052 (logrank test), Q value = 0.21

Table S15.  Gene #75: '19p loss' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 278 65 0.0 - 210.7 (19.8)
19P LOSS MUTATED 56 22 0.1 - 147.3 (19.5)
19P LOSS WILD-TYPE 222 43 0.0 - 210.7 (20.2)

Figure S15.  Get High-res Image Gene #75: '19p loss' versus Clinical Feature #1: 'Time to Death'

'20q loss' versus 'Time to Death'

P value = 0.000282 (logrank test), Q value = 0.18

Table S16.  Gene #78: '20q loss' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 278 65 0.0 - 210.7 (19.8)
20Q LOSS MUTATED 10 6 4.7 - 45.8 (12.9)
20Q LOSS WILD-TYPE 268 59 0.0 - 210.7 (20.0)

Figure S16.  Get High-res Image Gene #78: '20q loss' versus Clinical Feature #1: 'Time to Death'

Methods & Data
Input

  • Copy number data file = broad_values_by_arm.txt from GISTIC pipeline

  • Processed Copy number data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/CESC-TP/15082579/transformed.cor.cli.txt

  • Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/CESC-TP/15076797/CESC-TP.merged_data.txt

  • Number of patients = 292

  • Number of significantly arm-level cnvs = 82

  • Number of selected clinical features = 44

  • Exclude regions that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[3] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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