This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 12 different clustering approaches and 12 clinical features across 452 patients, 37 significant findings detected with P value < 0.05 and Q value < 0.25.
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CNMF clustering analysis on array-based mRNA expression data identified 4 subtypes that correlate to 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_N_STAGE', 'GENDER', 'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.
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Consensus hierarchical clustering analysis on array-based mRNA expression data identified 3 subtypes that correlate to 'HISTOLOGICAL_TYPE'.
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3 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes correlate to 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'HISTOLOGICAL_TYPE', 'COMPLETENESS_OF_RESECTION', and 'NUMBER_OF_LYMPH_NODES'.
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3 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes correlate to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.
-
CNMF clustering analysis on RPPA data identified 4 subtypes that correlate to 'HISTOLOGICAL_TYPE' and 'COMPLETENESS_OF_RESECTION'.
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Consensus hierarchical clustering analysis on RPPA data identified 6 subtypes that correlate to 'NEOPLASM_DISEASESTAGE' and 'NUMBER_OF_LYMPH_NODES'.
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CNMF clustering analysis on sequencing-based mRNA expression data identified 4 subtypes that correlate to 'YEARS_TO_BIRTH', 'PATHOLOGY_M_STAGE', 'HISTOLOGICAL_TYPE', and 'COMPLETENESS_OF_RESECTION'.
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Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 5 subtypes that correlate to 'YEARS_TO_BIRTH', 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_M_STAGE', 'HISTOLOGICAL_TYPE', and 'COMPLETENESS_OF_RESECTION'.
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3 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes correlate to 'YEARS_TO_BIRTH', 'NEOPLASM_DISEASESTAGE', and 'COMPLETENESS_OF_RESECTION'.
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4 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes correlate to 'YEARS_TO_BIRTH' and 'COMPLETENESS_OF_RESECTION'.
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3 subtypes identified in current cancer cohort by 'MIRseq Mature CNMF subtypes'. These subtypes correlate to 'YEARS_TO_BIRTH', 'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.
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5 subtypes identified in current cancer cohort by 'MIRseq Mature cHierClus subtypes'. These subtypes correlate to 'GENDER' and 'NUMBER_OF_LYMPH_NODES'.
Clinical Features |
Time to Death |
YEARS TO BIRTH |
NEOPLASM DISEASESTAGE |
PATHOLOGY T STAGE |
PATHOLOGY N STAGE |
PATHOLOGY M STAGE |
GENDER |
HISTOLOGICAL TYPE |
RADIATIONS RADIATION REGIMENINDICATION |
COMPLETENESS OF RESECTION |
NUMBER OF LYMPH NODES |
RACE |
Statistical Tests | logrank test | Kruskal-Wallis (anova) | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Kruskal-Wallis (anova) | Fisher's exact test |
mRNA CNMF subtypes |
0.866 (0.959) |
0.597 (0.782) |
0.00307 (0.0211) |
0.679 (0.822) |
0.00854 (0.0492) |
0.095 (0.277) |
0.0359 (0.157) |
2e-05 (0.00048) |
0.162 (0.376) |
0.00264 (0.019) |
0.455 (0.727) |
|
mRNA cHierClus subtypes |
0.367 (0.653) |
0.0658 (0.236) |
0.632 (0.813) |
0.647 (0.817) |
0.787 (0.922) |
0.598 (0.782) |
0.0837 (0.268) |
1e-05 (0.000288) |
0.546 (0.779) |
0.765 (0.903) |
1 (1.00) |
|
Copy Number Ratio CNMF subtypes |
0.833 (0.94) |
0.121 (0.318) |
0.00179 (0.0136) |
0.878 (0.96) |
0.0012 (0.0096) |
0.00015 (0.00196) |
0.56 (0.782) |
1e-05 (0.000288) |
0.202 (0.434) |
0.026 (0.129) |
0.00101 (0.00909) |
0.966 (1.00) |
METHLYATION CNMF |
0.957 (1.00) |
0.000552 (0.00543) |
0.385 (0.667) |
0.26 (0.519) |
0.423 (0.709) |
0.0531 (0.201) |
0.069 (0.236) |
0.0098 (0.0543) |
0.478 (0.748) |
0.536 (0.775) |
0.524 (0.775) |
0.574 (0.782) |
RPPA CNMF subtypes |
0.894 (0.96) |
0.88 (0.96) |
0.396 (0.671) |
0.647 (0.817) |
0.528 (0.775) |
0.0982 (0.277) |
0.827 (0.94) |
0.0353 (0.157) |
0.498 (0.763) |
0.00669 (0.0419) |
0.16 (0.376) |
0.176 (0.396) |
RPPA cHierClus subtypes |
0.154 (0.376) |
0.446 (0.721) |
0.0111 (0.0594) |
0.0755 (0.248) |
0.181 (0.402) |
0.667 (0.821) |
0.598 (0.782) |
0.446 (0.721) |
0.28 (0.537) |
0.0934 (0.277) |
0.0472 (0.184) |
0.264 (0.52) |
RNAseq CNMF subtypes |
0.658 (0.821) |
0.00769 (0.0461) |
0.102 (0.277) |
0.505 (0.765) |
0.391 (0.671) |
0.0336 (0.156) |
0.104 (0.277) |
3e-05 (0.00054) |
0.232 (0.478) |
3e-05 (0.00054) |
0.341 (0.622) |
0.332 (0.621) |
RNAseq cHierClus subtypes |
0.733 (0.872) |
0.000119 (0.00171) |
0.0004 (0.00443) |
0.829 (0.94) |
0.0986 (0.277) |
0.0392 (0.166) |
0.216 (0.457) |
1e-05 (0.000288) |
0.159 (0.376) |
1e-05 (0.000288) |
0.189 (0.413) |
0.932 (0.994) |
MIRSEQ CNMF |
0.104 (0.277) |
0.000566 (0.00543) |
0.0451 (0.184) |
0.384 (0.667) |
0.348 (0.627) |
0.566 (0.782) |
0.444 (0.721) |
0.0982 (0.277) |
0.0689 (0.236) |
1e-05 (0.000288) |
0.517 (0.775) |
0.675 (0.822) |
MIRSEQ CHIERARCHICAL |
0.853 (0.952) |
0.000101 (0.00162) |
0.135 (0.342) |
0.893 (0.96) |
0.099 (0.277) |
0.538 (0.775) |
0.477 (0.748) |
0.31 (0.587) |
0.0613 (0.226) |
0.00024 (0.00288) |
0.162 (0.376) |
0.279 (0.537) |
MIRseq Mature CNMF subtypes |
0.165 (0.377) |
0.00416 (0.0272) |
0.556 (0.782) |
0.582 (0.782) |
0.239 (0.485) |
0.227 (0.474) |
0.73 (0.872) |
0.033 (0.156) |
0.487 (0.753) |
0.0241 (0.124) |
0.662 (0.821) |
|
MIRseq Mature cHierClus subtypes |
0.603 (0.782) |
0.589 (0.782) |
0.816 (0.94) |
0.836 (0.94) |
0.0757 (0.248) |
0.128 (0.33) |
0.00115 (0.0096) |
0.339 (0.622) |
0.942 (0.997) |
0.0469 (0.184) |
0.993 (1.00) |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 38 | 61 | 30 | 24 |
P value = 0.866 (logrank test), Q value = 0.96
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 146 | 30 | 0.0 - 54.0 (23.5) |
subtype1 | 35 | 8 | 0.0 - 46.6 (24.0) |
subtype2 | 57 | 13 | 0.0 - 51.0 (24.0) |
subtype3 | 30 | 5 | 0.0 - 54.0 (18.6) |
subtype4 | 24 | 4 | 0.0 - 50.0 (26.0) |
P value = 0.597 (Kruskal-Wallis (anova)), Q value = 0.78
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 153 | 70.8 (11.5) |
subtype1 | 38 | 72.4 (11.4) |
subtype2 | 61 | 69.9 (11.7) |
subtype3 | 30 | 72.0 (10.9) |
subtype4 | 24 | 68.9 (12.3) |
P value = 0.00307 (Fisher's exact test), Q value = 0.021
nPatients | STAGE I | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|
ALL | 29 | 12 | 45 | 5 | 8 | 3 | 12 | 16 | 21 | 1 |
subtype1 | 6 | 1 | 14 | 3 | 3 | 1 | 3 | 1 | 5 | 0 |
subtype2 | 11 | 2 | 12 | 0 | 2 | 2 | 5 | 13 | 14 | 0 |
subtype3 | 7 | 6 | 9 | 2 | 1 | 0 | 3 | 0 | 1 | 1 |
subtype4 | 5 | 3 | 10 | 0 | 2 | 0 | 1 | 2 | 1 | 0 |
P value = 0.679 (Fisher's exact test), Q value = 0.82
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 4 | 31 | 103 | 15 |
subtype1 | 1 | 7 | 24 | 6 |
subtype2 | 2 | 12 | 42 | 5 |
subtype3 | 0 | 7 | 19 | 4 |
subtype4 | 1 | 5 | 18 | 0 |
P value = 0.00854 (Fisher's exact test), Q value = 0.049
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 94 | 28 | 31 |
subtype1 | 25 | 5 | 8 |
subtype2 | 27 | 15 | 19 |
subtype3 | 24 | 5 | 1 |
subtype4 | 18 | 3 | 3 |
P value = 0.095 (Fisher's exact test), Q value = 0.28
nPatients | 0 | 1 |
---|---|---|
ALL | 129 | 22 |
subtype1 | 32 | 5 |
subtype2 | 47 | 14 |
subtype3 | 28 | 2 |
subtype4 | 22 | 1 |
P value = 0.0359 (Fisher's exact test), Q value = 0.16
nPatients | FEMALE | MALE |
---|---|---|
ALL | 75 | 78 |
subtype1 | 25 | 13 |
subtype2 | 31 | 30 |
subtype3 | 10 | 20 |
subtype4 | 9 | 15 |
P value = 2e-05 (Fisher's exact test), Q value = 0.00048
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 129 | 22 |
subtype1 | 25 | 13 |
subtype2 | 60 | 1 |
subtype3 | 22 | 7 |
subtype4 | 22 | 1 |
P value = 0.162 (Fisher's exact test), Q value = 0.38
nPatients | R0 | R1 | R2 |
---|---|---|---|
ALL | 128 | 1 | 19 |
subtype1 | 32 | 0 | 3 |
subtype2 | 47 | 1 | 13 |
subtype3 | 28 | 0 | 2 |
subtype4 | 21 | 0 | 1 |
P value = 0.00264 (Kruskal-Wallis (anova)), Q value = 0.019
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 152 | 2.1 (4.5) |
subtype1 | 38 | 2.7 (5.8) |
subtype2 | 61 | 2.8 (4.8) |
subtype3 | 29 | 0.7 (2.3) |
subtype4 | 24 | 1.2 (2.6) |
P value = 0.455 (Fisher's exact test), Q value = 0.73
nPatients | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|
ALL | 1 | 11 |
subtype1 | 0 | 6 |
subtype2 | 1 | 4 |
subtype3 | 0 | 0 |
subtype4 | 0 | 1 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 46 | 73 | 34 |
P value = 0.367 (logrank test), Q value = 0.65
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 146 | 30 | 0.0 - 54.0 (23.5) |
subtype1 | 44 | 10 | 0.0 - 53.0 (22.5) |
subtype2 | 72 | 17 | 0.0 - 54.0 (23.0) |
subtype3 | 30 | 3 | 0.9 - 39.0 (24.0) |
P value = 0.0658 (Kruskal-Wallis (anova)), Q value = 0.24
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 153 | 70.8 (11.5) |
subtype1 | 46 | 73.4 (11.8) |
subtype2 | 73 | 70.6 (10.6) |
subtype3 | 34 | 67.5 (12.5) |
P value = 0.632 (Fisher's exact test), Q value = 0.81
nPatients | STAGE I | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|
ALL | 29 | 12 | 45 | 5 | 8 | 3 | 12 | 16 | 21 | 1 |
subtype1 | 9 | 3 | 14 | 4 | 3 | 1 | 5 | 1 | 5 | 0 |
subtype2 | 12 | 7 | 20 | 1 | 4 | 2 | 4 | 10 | 12 | 1 |
subtype3 | 8 | 2 | 11 | 0 | 1 | 0 | 3 | 5 | 4 | 0 |
P value = 0.647 (Fisher's exact test), Q value = 0.82
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 4 | 31 | 103 | 15 |
subtype1 | 1 | 10 | 28 | 7 |
subtype2 | 2 | 13 | 51 | 7 |
subtype3 | 1 | 8 | 24 | 1 |
P value = 0.787 (Fisher's exact test), Q value = 0.92
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 94 | 28 | 31 |
subtype1 | 31 | 7 | 8 |
subtype2 | 42 | 16 | 15 |
subtype3 | 21 | 5 | 8 |
P value = 0.598 (Fisher's exact test), Q value = 0.78
nPatients | 0 | 1 |
---|---|---|
ALL | 129 | 22 |
subtype1 | 40 | 5 |
subtype2 | 60 | 13 |
subtype3 | 29 | 4 |
P value = 0.0837 (Fisher's exact test), Q value = 0.27
nPatients | FEMALE | MALE |
---|---|---|
ALL | 75 | 78 |
subtype1 | 28 | 18 |
subtype2 | 35 | 38 |
subtype3 | 12 | 22 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00029
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 129 | 22 |
subtype1 | 27 | 18 |
subtype2 | 69 | 4 |
subtype3 | 33 | 0 |
P value = 0.546 (Fisher's exact test), Q value = 0.78
nPatients | R0 | R1 | R2 |
---|---|---|---|
ALL | 128 | 1 | 19 |
subtype1 | 39 | 0 | 3 |
subtype2 | 60 | 1 | 12 |
subtype3 | 29 | 0 | 4 |
P value = 0.765 (Kruskal-Wallis (anova)), Q value = 0.9
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 152 | 2.1 (4.5) |
subtype1 | 46 | 2.3 (5.3) |
subtype2 | 72 | 2.2 (4.6) |
subtype3 | 34 | 1.7 (2.7) |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|
ALL | 1 | 11 |
subtype1 | 0 | 5 |
subtype2 | 1 | 5 |
subtype3 | 0 | 1 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 201 | 165 | 77 |
P value = 0.833 (logrank test), Q value = 0.94
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 430 | 93 | 0.0 - 140.4 (20.4) |
subtype1 | 194 | 45 | 0.0 - 140.4 (20.2) |
subtype2 | 159 | 32 | 0.1 - 131.5 (22.0) |
subtype3 | 77 | 16 | 0.0 - 119.7 (18.1) |
P value = 0.121 (Kruskal-Wallis (anova)), Q value = 0.32
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 441 | 67.0 (13.0) |
subtype1 | 199 | 68.1 (14.1) |
subtype2 | 165 | 66.3 (12.1) |
subtype3 | 77 | 65.5 (11.8) |
P value = 0.00179 (Fisher's exact test), Q value = 0.014
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 74 | 1 | 28 | 131 | 8 | 1 | 21 | 12 | 56 | 39 | 43 | 18 | 2 |
subtype1 | 39 | 1 | 13 | 75 | 6 | 0 | 10 | 3 | 21 | 14 | 11 | 3 | 1 |
subtype2 | 21 | 0 | 5 | 40 | 2 | 1 | 7 | 7 | 23 | 18 | 23 | 12 | 1 |
subtype3 | 14 | 0 | 10 | 16 | 0 | 0 | 4 | 2 | 12 | 7 | 9 | 3 | 0 |
P value = 0.878 (Fisher's exact test), Q value = 0.96
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 11 | 78 | 301 | 52 |
subtype1 | 5 | 38 | 131 | 26 |
subtype2 | 5 | 25 | 116 | 19 |
subtype3 | 1 | 15 | 54 | 7 |
P value = 0.0012 (Fisher's exact test), Q value = 0.0096
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 257 | 104 | 81 |
subtype1 | 137 | 35 | 29 |
subtype2 | 76 | 51 | 37 |
subtype3 | 44 | 18 | 15 |
P value = 0.00015 (Fisher's exact test), Q value = 0.002
nPatients | 0 | 1 |
---|---|---|
ALL | 322 | 62 |
subtype1 | 159 | 14 |
subtype2 | 108 | 36 |
subtype3 | 55 | 12 |
P value = 0.56 (Fisher's exact test), Q value = 0.78
nPatients | FEMALE | MALE |
---|---|---|
ALL | 210 | 233 |
subtype1 | 101 | 100 |
subtype2 | 74 | 91 |
subtype3 | 35 | 42 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00029
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 381 | 60 |
subtype1 | 153 | 47 |
subtype2 | 158 | 6 |
subtype3 | 70 | 7 |
P value = 0.202 (Fisher's exact test), Q value = 0.43
nPatients | NO | YES |
---|---|---|
ALL | 3 | 440 |
subtype1 | 0 | 201 |
subtype2 | 2 | 163 |
subtype3 | 1 | 76 |
P value = 0.026 (Fisher's exact test), Q value = 0.13
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 316 | 3 | 24 | 25 |
subtype1 | 146 | 2 | 4 | 16 |
subtype2 | 118 | 1 | 13 | 6 |
subtype3 | 52 | 0 | 7 | 3 |
P value = 0.00101 (Kruskal-Wallis (anova)), Q value = 0.0091
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 418 | 2.1 (4.5) |
subtype1 | 188 | 1.7 (4.1) |
subtype2 | 157 | 2.6 (5.3) |
subtype3 | 73 | 1.9 (3.3) |
P value = 0.966 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 11 | 54 | 211 |
subtype1 | 1 | 6 | 24 | 98 |
subtype2 | 0 | 3 | 22 | 78 |
subtype3 | 0 | 2 | 8 | 35 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 115 | 99 | 74 |
P value = 0.957 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 284 | 62 | 0.1 - 140.4 (19.8) |
subtype1 | 113 | 27 | 0.1 - 140.4 (23.5) |
subtype2 | 97 | 21 | 0.1 - 135.7 (19.3) |
subtype3 | 74 | 14 | 0.1 - 102.4 (16.2) |
P value = 0.000552 (Kruskal-Wallis (anova)), Q value = 0.0054
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 286 | 64.9 (13.2) |
subtype1 | 115 | 66.1 (12.5) |
subtype2 | 99 | 67.2 (13.2) |
subtype3 | 72 | 59.9 (13.0) |
P value = 0.385 (Fisher's exact test), Q value = 0.67
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 43 | 1 | 14 | 92 | 5 | 1 | 7 | 9 | 44 | 24 | 21 | 17 | 2 |
subtype1 | 16 | 0 | 6 | 29 | 1 | 1 | 3 | 4 | 20 | 9 | 11 | 10 | 1 |
subtype2 | 21 | 1 | 3 | 33 | 3 | 0 | 4 | 2 | 13 | 8 | 4 | 4 | 1 |
subtype3 | 6 | 0 | 5 | 30 | 1 | 0 | 0 | 3 | 11 | 7 | 6 | 3 | 0 |
P value = 0.26 (Fisher's exact test), Q value = 0.52
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 7 | 44 | 198 | 38 |
subtype1 | 3 | 19 | 78 | 15 |
subtype2 | 3 | 20 | 63 | 12 |
subtype3 | 1 | 5 | 57 | 11 |
P value = 0.423 (Fisher's exact test), Q value = 0.71
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 167 | 72 | 48 |
subtype1 | 59 | 33 | 22 |
subtype2 | 64 | 20 | 15 |
subtype3 | 44 | 19 | 11 |
P value = 0.0531 (Fisher's exact test), Q value = 0.2
nPatients | 0 | 1 |
---|---|---|
ALL | 192 | 39 |
subtype1 | 69 | 22 |
subtype2 | 68 | 8 |
subtype3 | 55 | 9 |
P value = 0.069 (Fisher's exact test), Q value = 0.24
nPatients | FEMALE | MALE |
---|---|---|
ALL | 133 | 155 |
subtype1 | 48 | 67 |
subtype2 | 55 | 44 |
subtype3 | 30 | 44 |
P value = 0.0098 (Fisher's exact test), Q value = 0.054
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 250 | 38 |
subtype1 | 108 | 7 |
subtype2 | 82 | 17 |
subtype3 | 60 | 14 |
P value = 0.478 (Fisher's exact test), Q value = 0.75
nPatients | NO | YES |
---|---|---|
ALL | 3 | 285 |
subtype1 | 2 | 113 |
subtype2 | 0 | 99 |
subtype3 | 1 | 73 |
P value = 0.536 (Fisher's exact test), Q value = 0.78
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 187 | 2 | 4 | 24 |
subtype1 | 74 | 0 | 3 | 8 |
subtype2 | 64 | 2 | 1 | 10 |
subtype3 | 49 | 0 | 0 | 6 |
P value = 0.524 (Kruskal-Wallis (anova)), Q value = 0.78
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 264 | 2.0 (4.5) |
subtype1 | 105 | 2.4 (5.9) |
subtype2 | 91 | 1.5 (2.6) |
subtype3 | 68 | 2.0 (3.7) |
P value = 0.574 (Fisher's exact test), Q value = 0.78
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 11 | 53 | 205 |
subtype1 | 0 | 4 | 20 | 80 |
subtype2 | 0 | 2 | 19 | 73 |
subtype3 | 1 | 5 | 14 | 52 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 80 | 128 | 27 | 96 |
P value = 0.894 (logrank test), Q value = 0.96
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 324 | 69 | 0.0 - 140.4 (21.0) |
subtype1 | 79 | 13 | 0.0 - 131.5 (23.0) |
subtype2 | 122 | 29 | 0.1 - 140.4 (21.2) |
subtype3 | 27 | 5 | 0.0 - 52.0 (24.0) |
subtype4 | 96 | 22 | 0.0 - 135.7 (19.5) |
P value = 0.88 (Kruskal-Wallis (anova)), Q value = 0.96
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 330 | 67.3 (13.0) |
subtype1 | 80 | 66.8 (12.9) |
subtype2 | 127 | 68.1 (12.3) |
subtype3 | 27 | 66.9 (11.9) |
subtype4 | 96 | 66.7 (14.3) |
P value = 0.396 (Fisher's exact test), Q value = 0.67
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 49 | 1 | 20 | 108 | 8 | 1 | 18 | 8 | 43 | 29 | 28 | 14 | 1 |
subtype1 | 10 | 0 | 6 | 23 | 3 | 0 | 2 | 3 | 14 | 10 | 5 | 4 | 0 |
subtype2 | 18 | 0 | 10 | 34 | 3 | 1 | 8 | 2 | 18 | 8 | 18 | 5 | 1 |
subtype3 | 3 | 1 | 1 | 12 | 0 | 0 | 2 | 0 | 3 | 3 | 1 | 1 | 0 |
subtype4 | 18 | 0 | 3 | 39 | 2 | 0 | 6 | 3 | 8 | 8 | 4 | 4 | 0 |
P value = 0.647 (Fisher's exact test), Q value = 0.82
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 6 | 53 | 233 | 38 |
subtype1 | 0 | 12 | 59 | 9 |
subtype2 | 2 | 21 | 90 | 15 |
subtype3 | 0 | 3 | 22 | 1 |
subtype4 | 4 | 17 | 62 | 13 |
P value = 0.528 (Fisher's exact test), Q value = 0.78
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 196 | 80 | 55 |
subtype1 | 42 | 23 | 15 |
subtype2 | 72 | 32 | 24 |
subtype3 | 17 | 6 | 4 |
subtype4 | 65 | 19 | 12 |
P value = 0.0982 (Fisher's exact test), Q value = 0.28
nPatients | 0 | 1 |
---|---|---|
ALL | 259 | 43 |
subtype1 | 65 | 9 |
subtype2 | 92 | 24 |
subtype3 | 24 | 2 |
subtype4 | 78 | 8 |
P value = 0.827 (Fisher's exact test), Q value = 0.94
nPatients | FEMALE | MALE |
---|---|---|
ALL | 155 | 176 |
subtype1 | 38 | 42 |
subtype2 | 56 | 72 |
subtype3 | 13 | 14 |
subtype4 | 48 | 48 |
P value = 0.0353 (Fisher's exact test), Q value = 0.16
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 293 | 38 |
subtype1 | 68 | 12 |
subtype2 | 121 | 7 |
subtype3 | 23 | 4 |
subtype4 | 81 | 15 |
P value = 0.498 (Fisher's exact test), Q value = 0.76
nPatients | NO | YES |
---|---|---|
ALL | 3 | 328 |
subtype1 | 2 | 78 |
subtype2 | 1 | 127 |
subtype3 | 0 | 27 |
subtype4 | 0 | 96 |
P value = 0.00669 (Fisher's exact test), Q value = 0.042
nPatients | R0 | R2 | RX |
---|---|---|---|
ALL | 241 | 16 | 16 |
subtype1 | 61 | 1 | 6 |
subtype2 | 78 | 13 | 6 |
subtype3 | 26 | 1 | 0 |
subtype4 | 76 | 1 | 4 |
P value = 0.16 (Kruskal-Wallis (anova)), Q value = 0.38
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 311 | 2.0 (4.5) |
subtype1 | 74 | 2.9 (6.8) |
subtype2 | 120 | 2.0 (3.8) |
subtype3 | 27 | 1.7 (3.3) |
subtype4 | 90 | 1.2 (2.6) |
P value = 0.176 (Fisher's exact test), Q value = 0.4
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 11 | 21 | 181 |
subtype1 | 1 | 5 | 7 | 43 |
subtype2 | 0 | 5 | 6 | 63 |
subtype3 | 0 | 0 | 2 | 6 |
subtype4 | 0 | 1 | 6 | 69 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 |
---|---|---|---|---|---|---|
Number of samples | 60 | 49 | 56 | 68 | 69 | 29 |
P value = 0.154 (logrank test), Q value = 0.38
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 324 | 69 | 0.0 - 140.4 (21.0) |
subtype1 | 59 | 8 | 0.1 - 131.5 (20.0) |
subtype2 | 47 | 10 | 0.0 - 85.0 (24.3) |
subtype3 | 55 | 18 | 0.1 - 119.9 (18.0) |
subtype4 | 65 | 11 | 0.2 - 140.4 (23.9) |
subtype5 | 69 | 12 | 0.0 - 135.7 (20.0) |
subtype6 | 29 | 10 | 2.0 - 107.7 (18.1) |
P value = 0.446 (Kruskal-Wallis (anova)), Q value = 0.72
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 330 | 67.3 (13.0) |
subtype1 | 60 | 66.2 (11.5) |
subtype2 | 49 | 70.1 (12.9) |
subtype3 | 55 | 67.5 (14.0) |
subtype4 | 68 | 66.5 (12.4) |
subtype5 | 69 | 66.1 (14.0) |
subtype6 | 29 | 68.9 (13.1) |
P value = 0.0111 (Fisher's exact test), Q value = 0.059
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 49 | 1 | 20 | 108 | 8 | 1 | 18 | 8 | 43 | 29 | 28 | 14 | 1 |
subtype1 | 7 | 0 | 1 | 22 | 1 | 0 | 0 | 2 | 10 | 7 | 4 | 6 | 0 |
subtype2 | 10 | 0 | 7 | 7 | 1 | 0 | 6 | 1 | 5 | 4 | 7 | 1 | 0 |
subtype3 | 6 | 0 | 2 | 16 | 3 | 1 | 1 | 0 | 11 | 7 | 6 | 2 | 1 |
subtype4 | 7 | 1 | 6 | 20 | 1 | 0 | 7 | 2 | 10 | 4 | 6 | 2 | 0 |
subtype5 | 17 | 0 | 2 | 28 | 1 | 0 | 2 | 3 | 4 | 6 | 3 | 3 | 0 |
subtype6 | 2 | 0 | 2 | 15 | 1 | 0 | 2 | 0 | 3 | 1 | 2 | 0 | 0 |
P value = 0.0755 (Fisher's exact test), Q value = 0.25
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 6 | 53 | 233 | 38 |
subtype1 | 0 | 7 | 45 | 8 |
subtype2 | 0 | 13 | 33 | 3 |
subtype3 | 0 | 7 | 38 | 11 |
subtype4 | 2 | 8 | 51 | 6 |
subtype5 | 4 | 16 | 42 | 7 |
subtype6 | 0 | 2 | 24 | 3 |
P value = 0.181 (Fisher's exact test), Q value = 0.4
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 196 | 80 | 55 |
subtype1 | 32 | 15 | 13 |
subtype2 | 28 | 13 | 8 |
subtype3 | 28 | 15 | 13 |
subtype4 | 37 | 22 | 9 |
subtype5 | 51 | 10 | 8 |
subtype6 | 20 | 5 | 4 |
P value = 0.667 (Fisher's exact test), Q value = 0.82
nPatients | 0 | 1 |
---|---|---|
ALL | 259 | 43 |
subtype1 | 46 | 10 |
subtype2 | 40 | 8 |
subtype3 | 42 | 9 |
subtype4 | 51 | 8 |
subtype5 | 57 | 6 |
subtype6 | 23 | 2 |
P value = 0.598 (Fisher's exact test), Q value = 0.78
nPatients | FEMALE | MALE |
---|---|---|
ALL | 155 | 176 |
subtype1 | 27 | 33 |
subtype2 | 25 | 24 |
subtype3 | 23 | 33 |
subtype4 | 34 | 34 |
subtype5 | 29 | 40 |
subtype6 | 17 | 12 |
P value = 0.446 (Fisher's exact test), Q value = 0.72
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 293 | 38 |
subtype1 | 51 | 9 |
subtype2 | 46 | 3 |
subtype3 | 52 | 4 |
subtype4 | 61 | 7 |
subtype5 | 58 | 11 |
subtype6 | 25 | 4 |
P value = 0.28 (Fisher's exact test), Q value = 0.54
nPatients | NO | YES |
---|---|---|
ALL | 3 | 328 |
subtype1 | 2 | 58 |
subtype2 | 0 | 49 |
subtype3 | 1 | 55 |
subtype4 | 0 | 68 |
subtype5 | 0 | 69 |
subtype6 | 0 | 29 |
P value = 0.0934 (Fisher's exact test), Q value = 0.28
nPatients | R0 | R2 | RX |
---|---|---|---|
ALL | 241 | 16 | 16 |
subtype1 | 44 | 2 | 2 |
subtype2 | 40 | 5 | 1 |
subtype3 | 30 | 1 | 7 |
subtype4 | 49 | 5 | 2 |
subtype5 | 56 | 1 | 3 |
subtype6 | 22 | 2 | 1 |
P value = 0.0472 (Kruskal-Wallis (anova)), Q value = 0.18
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 311 | 2.0 (4.5) |
subtype1 | 56 | 3.2 (7.6) |
subtype2 | 48 | 1.5 (2.3) |
subtype3 | 51 | 2.8 (5.0) |
subtype4 | 65 | 1.6 (3.0) |
subtype5 | 64 | 1.2 (3.0) |
subtype6 | 27 | 1.2 (2.5) |
P value = 0.264 (Fisher's exact test), Q value = 0.52
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 11 | 21 | 181 |
subtype1 | 0 | 3 | 5 | 43 |
subtype2 | 0 | 0 | 1 | 14 |
subtype3 | 1 | 4 | 4 | 41 |
subtype4 | 0 | 1 | 7 | 19 |
subtype5 | 0 | 1 | 3 | 50 |
subtype6 | 0 | 2 | 1 | 14 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 117 | 108 | 90 | 135 |
P value = 0.658 (logrank test), Q value = 0.82
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 438 | 94 | 0.0 - 140.4 (21.0) |
subtype1 | 114 | 29 | 0.1 - 140.4 (24.5) |
subtype2 | 106 | 20 | 0.0 - 135.7 (19.8) |
subtype3 | 89 | 20 | 0.1 - 100.0 (15.6) |
subtype4 | 129 | 25 | 0.0 - 83.8 (22.0) |
P value = 0.00769 (Kruskal-Wallis (anova)), Q value = 0.046
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 448 | 67.0 (13.0) |
subtype1 | 117 | 64.9 (12.9) |
subtype2 | 107 | 67.2 (13.4) |
subtype3 | 89 | 65.1 (12.9) |
subtype4 | 135 | 69.9 (12.4) |
P value = 0.102 (Fisher's exact test), Q value = 0.28
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 74 | 1 | 29 | 136 | 9 | 1 | 21 | 12 | 56 | 39 | 43 | 18 | 2 |
subtype1 | 19 | 0 | 6 | 28 | 0 | 1 | 4 | 3 | 18 | 9 | 13 | 11 | 0 |
subtype2 | 22 | 1 | 9 | 36 | 3 | 0 | 5 | 3 | 12 | 7 | 5 | 3 | 2 |
subtype3 | 10 | 0 | 4 | 33 | 1 | 0 | 2 | 2 | 13 | 9 | 10 | 3 | 0 |
subtype4 | 23 | 0 | 10 | 39 | 5 | 0 | 10 | 4 | 13 | 14 | 15 | 1 | 0 |
P value = 0.505 (Fisher's exact test), Q value = 0.76
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 11 | 78 | 306 | 54 |
subtype1 | 3 | 24 | 76 | 14 |
subtype2 | 2 | 21 | 72 | 12 |
subtype3 | 1 | 9 | 65 | 15 |
subtype4 | 5 | 24 | 93 | 13 |
P value = 0.391 (Fisher's exact test), Q value = 0.67
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 264 | 104 | 81 |
subtype1 | 63 | 32 | 21 |
subtype2 | 73 | 21 | 14 |
subtype3 | 49 | 22 | 19 |
subtype4 | 79 | 29 | 27 |
P value = 0.0336 (Fisher's exact test), Q value = 0.16
nPatients | 0 | 1 |
---|---|---|
ALL | 329 | 62 |
subtype1 | 73 | 24 |
subtype2 | 77 | 9 |
subtype3 | 63 | 13 |
subtype4 | 116 | 16 |
P value = 0.104 (Fisher's exact test), Q value = 0.28
nPatients | FEMALE | MALE |
---|---|---|
ALL | 213 | 237 |
subtype1 | 47 | 70 |
subtype2 | 56 | 52 |
subtype3 | 38 | 52 |
subtype4 | 72 | 63 |
P value = 3e-05 (Fisher's exact test), Q value = 0.00054
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 387 | 61 |
subtype1 | 114 | 3 |
subtype2 | 82 | 25 |
subtype3 | 76 | 14 |
subtype4 | 115 | 19 |
P value = 0.232 (Fisher's exact test), Q value = 0.48
nPatients | NO | YES |
---|---|---|
ALL | 3 | 447 |
subtype1 | 2 | 115 |
subtype2 | 0 | 108 |
subtype3 | 1 | 89 |
subtype4 | 0 | 135 |
P value = 3e-05 (Fisher's exact test), Q value = 0.00054
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 323 | 3 | 23 | 25 |
subtype1 | 68 | 0 | 8 | 7 |
subtype2 | 71 | 2 | 2 | 11 |
subtype3 | 67 | 0 | 1 | 7 |
subtype4 | 117 | 1 | 12 | 0 |
P value = 0.341 (Kruskal-Wallis (anova)), Q value = 0.62
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 425 | 2.1 (4.4) |
subtype1 | 109 | 2.0 (4.1) |
subtype2 | 100 | 1.4 (3.0) |
subtype3 | 83 | 2.9 (6.8) |
subtype4 | 133 | 2.0 (3.6) |
P value = 0.332 (Fisher's exact test), Q value = 0.62
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 11 | 54 | 213 |
subtype1 | 0 | 4 | 15 | 69 |
subtype2 | 0 | 4 | 24 | 57 |
subtype3 | 1 | 3 | 12 | 69 |
subtype4 | 0 | 0 | 3 | 18 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 79 | 104 | 95 | 133 | 39 |
P value = 0.733 (logrank test), Q value = 0.87
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 438 | 94 | 0.0 - 140.4 (21.0) |
subtype1 | 79 | 17 | 0.3 - 91.8 (16.3) |
subtype2 | 102 | 22 | 0.1 - 140.4 (22.0) |
subtype3 | 93 | 22 | 0.1 - 135.7 (19.3) |
subtype4 | 126 | 25 | 0.0 - 83.8 (24.0) |
subtype5 | 38 | 8 | 0.0 - 54.0 (23.5) |
P value = 0.000119 (Kruskal-Wallis (anova)), Q value = 0.0017
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 448 | 67.0 (13.0) |
subtype1 | 79 | 65.4 (13.1) |
subtype2 | 104 | 65.0 (12.0) |
subtype3 | 93 | 64.9 (14.5) |
subtype4 | 133 | 68.6 (12.3) |
subtype5 | 39 | 74.9 (10.4) |
P value = 4e-04 (Fisher's exact test), Q value = 0.0044
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 74 | 1 | 29 | 136 | 9 | 1 | 21 | 12 | 56 | 39 | 43 | 18 | 2 |
subtype1 | 9 | 0 | 3 | 25 | 1 | 0 | 2 | 2 | 15 | 5 | 7 | 8 | 0 |
subtype2 | 15 | 0 | 8 | 32 | 0 | 1 | 3 | 2 | 17 | 7 | 7 | 8 | 0 |
subtype3 | 20 | 1 | 4 | 31 | 2 | 0 | 4 | 3 | 9 | 11 | 5 | 1 | 2 |
subtype4 | 24 | 0 | 9 | 35 | 2 | 0 | 8 | 5 | 10 | 16 | 23 | 1 | 0 |
subtype5 | 6 | 0 | 5 | 13 | 4 | 0 | 4 | 0 | 5 | 0 | 1 | 0 | 0 |
P value = 0.829 (Fisher's exact test), Q value = 0.94
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 11 | 78 | 306 | 54 |
subtype1 | 1 | 10 | 55 | 13 |
subtype2 | 2 | 17 | 74 | 11 |
subtype3 | 3 | 18 | 60 | 13 |
subtype4 | 4 | 27 | 91 | 11 |
subtype5 | 1 | 6 | 26 | 6 |
P value = 0.0986 (Fisher's exact test), Q value = 0.28
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 264 | 104 | 81 |
subtype1 | 39 | 28 | 12 |
subtype2 | 63 | 23 | 17 |
subtype3 | 60 | 18 | 17 |
subtype4 | 73 | 29 | 31 |
subtype5 | 29 | 6 | 4 |
P value = 0.0392 (Fisher's exact test), Q value = 0.17
nPatients | 0 | 1 |
---|---|---|
ALL | 329 | 62 |
subtype1 | 52 | 15 |
subtype2 | 68 | 14 |
subtype3 | 65 | 8 |
subtype4 | 107 | 24 |
subtype5 | 37 | 1 |
P value = 0.216 (Fisher's exact test), Q value = 0.46
nPatients | FEMALE | MALE |
---|---|---|
ALL | 213 | 237 |
subtype1 | 33 | 46 |
subtype2 | 46 | 58 |
subtype3 | 46 | 49 |
subtype4 | 63 | 70 |
subtype5 | 25 | 14 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00029
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 387 | 61 |
subtype1 | 73 | 6 |
subtype2 | 96 | 8 |
subtype3 | 72 | 23 |
subtype4 | 125 | 7 |
subtype5 | 21 | 17 |
P value = 0.159 (Fisher's exact test), Q value = 0.38
nPatients | NO | YES |
---|---|---|
ALL | 3 | 447 |
subtype1 | 2 | 77 |
subtype2 | 1 | 103 |
subtype3 | 0 | 95 |
subtype4 | 0 | 133 |
subtype5 | 0 | 39 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00029
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 323 | 3 | 23 | 25 |
subtype1 | 59 | 0 | 0 | 5 |
subtype2 | 59 | 0 | 2 | 9 |
subtype3 | 59 | 2 | 1 | 11 |
subtype4 | 110 | 1 | 20 | 0 |
subtype5 | 36 | 0 | 0 | 0 |
P value = 0.189 (Kruskal-Wallis (anova)), Q value = 0.41
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 425 | 2.1 (4.4) |
subtype1 | 74 | 2.5 (6.5) |
subtype2 | 95 | 1.7 (3.1) |
subtype3 | 86 | 1.8 (3.4) |
subtype4 | 131 | 2.5 (4.8) |
subtype5 | 39 | 1.0 (2.2) |
P value = 0.932 (Fisher's exact test), Q value = 0.99
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 11 | 54 | 213 |
subtype1 | 0 | 3 | 13 | 60 |
subtype2 | 0 | 3 | 21 | 65 |
subtype3 | 1 | 5 | 16 | 68 |
subtype4 | 0 | 0 | 4 | 15 |
subtype5 | 0 | 0 | 0 | 5 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 160 | 66 | 180 |
P value = 0.104 (logrank test), Q value = 0.28
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 394 | 86 | 0.0 - 140.4 (21.9) |
subtype1 | 158 | 31 | 0.1 - 140.4 (20.9) |
subtype2 | 66 | 15 | 0.1 - 100.0 (14.6) |
subtype3 | 170 | 40 | 0.0 - 83.8 (24.2) |
P value = 0.000566 (Kruskal-Wallis (anova)), Q value = 0.0054
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 405 | 67.3 (13.0) |
subtype1 | 159 | 66.5 (12.4) |
subtype2 | 66 | 62.6 (14.4) |
subtype3 | 180 | 69.9 (12.5) |
P value = 0.0451 (Fisher's exact test), Q value = 0.18
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 66 | 1 | 28 | 121 | 8 | 1 | 21 | 11 | 49 | 32 | 42 | 16 | 1 |
subtype1 | 24 | 1 | 7 | 56 | 2 | 1 | 7 | 4 | 24 | 11 | 11 | 7 | 1 |
subtype2 | 7 | 0 | 3 | 21 | 0 | 0 | 2 | 3 | 10 | 8 | 4 | 4 | 0 |
subtype3 | 35 | 0 | 18 | 44 | 6 | 0 | 12 | 4 | 15 | 13 | 27 | 5 | 0 |
P value = 0.384 (Fisher's exact test), Q value = 0.67
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 11 | 69 | 279 | 46 |
subtype1 | 5 | 24 | 115 | 15 |
subtype2 | 0 | 9 | 46 | 11 |
subtype3 | 6 | 36 | 118 | 20 |
P value = 0.348 (Fisher's exact test), Q value = 0.63
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 238 | 95 | 72 |
subtype1 | 97 | 39 | 23 |
subtype2 | 33 | 19 | 14 |
subtype3 | 108 | 37 | 35 |
P value = 0.566 (Fisher's exact test), Q value = 0.78
nPatients | 0 | 1 |
---|---|---|
ALL | 305 | 58 |
subtype1 | 113 | 18 |
subtype2 | 48 | 8 |
subtype3 | 144 | 32 |
P value = 0.444 (Fisher's exact test), Q value = 0.72
nPatients | FEMALE | MALE |
---|---|---|
ALL | 191 | 215 |
subtype1 | 74 | 86 |
subtype2 | 27 | 39 |
subtype3 | 90 | 90 |
P value = 0.0982 (Fisher's exact test), Q value = 0.28
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 351 | 53 |
subtype1 | 145 | 15 |
subtype2 | 53 | 13 |
subtype3 | 153 | 25 |
P value = 0.0689 (Fisher's exact test), Q value = 0.24
nPatients | NO | YES |
---|---|---|
ALL | 3 | 403 |
subtype1 | 0 | 160 |
subtype2 | 2 | 64 |
subtype3 | 1 | 179 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00029
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 282 | 3 | 25 | 22 |
subtype1 | 94 | 1 | 2 | 15 |
subtype2 | 43 | 0 | 0 | 5 |
subtype3 | 145 | 2 | 23 | 2 |
P value = 0.517 (Kruskal-Wallis (anova)), Q value = 0.78
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 382 | 2.0 (4.5) |
subtype1 | 146 | 1.6 (3.0) |
subtype2 | 61 | 3.2 (8.0) |
subtype3 | 175 | 2.0 (3.8) |
P value = 0.675 (Fisher's exact test), Q value = 0.82
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 11 | 23 | 213 |
subtype1 | 0 | 7 | 12 | 132 |
subtype2 | 1 | 3 | 7 | 51 |
subtype3 | 0 | 1 | 4 | 30 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 136 | 50 | 79 | 141 |
P value = 0.853 (logrank test), Q value = 0.95
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 394 | 86 | 0.0 - 140.4 (21.9) |
subtype1 | 134 | 31 | 0.2 - 140.4 (20.5) |
subtype2 | 50 | 9 | 0.1 - 100.0 (15.5) |
subtype3 | 76 | 17 | 0.0 - 139.2 (18.6) |
subtype4 | 134 | 29 | 0.0 - 131.5 (27.0) |
P value = 0.000101 (Kruskal-Wallis (anova)), Q value = 0.0016
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 405 | 67.3 (13.0) |
subtype1 | 135 | 66.3 (13.3) |
subtype2 | 50 | 63.2 (13.1) |
subtype3 | 79 | 64.9 (13.1) |
subtype4 | 141 | 71.2 (11.9) |
P value = 0.135 (Fisher's exact test), Q value = 0.34
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 66 | 1 | 28 | 121 | 8 | 1 | 21 | 11 | 49 | 32 | 42 | 16 | 1 |
subtype1 | 20 | 0 | 7 | 50 | 4 | 1 | 6 | 3 | 15 | 10 | 9 | 6 | 1 |
subtype2 | 6 | 0 | 2 | 19 | 0 | 0 | 1 | 3 | 8 | 2 | 3 | 4 | 0 |
subtype3 | 11 | 1 | 4 | 19 | 0 | 0 | 4 | 3 | 12 | 8 | 14 | 1 | 0 |
subtype4 | 29 | 0 | 15 | 33 | 4 | 0 | 10 | 2 | 14 | 12 | 16 | 5 | 0 |
P value = 0.893 (Fisher's exact test), Q value = 0.96
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 11 | 69 | 279 | 46 |
subtype1 | 4 | 21 | 94 | 17 |
subtype2 | 1 | 6 | 39 | 4 |
subtype3 | 2 | 13 | 56 | 7 |
subtype4 | 4 | 29 | 90 | 18 |
P value = 0.099 (Fisher's exact test), Q value = 0.28
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 238 | 95 | 72 |
subtype1 | 89 | 26 | 20 |
subtype2 | 27 | 17 | 6 |
subtype3 | 38 | 21 | 20 |
subtype4 | 84 | 31 | 26 |
P value = 0.538 (Fisher's exact test), Q value = 0.78
nPatients | 0 | 1 |
---|---|---|
ALL | 305 | 58 |
subtype1 | 97 | 15 |
subtype2 | 36 | 7 |
subtype3 | 55 | 15 |
subtype4 | 117 | 21 |
P value = 0.477 (Fisher's exact test), Q value = 0.75
nPatients | FEMALE | MALE |
---|---|---|
ALL | 191 | 215 |
subtype1 | 57 | 79 |
subtype2 | 23 | 27 |
subtype3 | 40 | 39 |
subtype4 | 71 | 70 |
P value = 0.31 (Fisher's exact test), Q value = 0.59
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 351 | 53 |
subtype1 | 120 | 16 |
subtype2 | 40 | 10 |
subtype3 | 71 | 7 |
subtype4 | 120 | 20 |
P value = 0.0613 (Fisher's exact test), Q value = 0.23
nPatients | NO | YES |
---|---|---|
ALL | 3 | 403 |
subtype1 | 0 | 136 |
subtype2 | 2 | 48 |
subtype3 | 0 | 79 |
subtype4 | 1 | 140 |
P value = 0.00024 (Fisher's exact test), Q value = 0.0029
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 282 | 3 | 25 | 22 |
subtype1 | 76 | 1 | 3 | 11 |
subtype2 | 37 | 0 | 0 | 5 |
subtype3 | 51 | 1 | 9 | 5 |
subtype4 | 118 | 1 | 13 | 1 |
P value = 0.162 (Kruskal-Wallis (anova)), Q value = 0.38
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 382 | 2.0 (4.5) |
subtype1 | 128 | 1.6 (3.2) |
subtype2 | 44 | 1.6 (2.9) |
subtype3 | 72 | 2.9 (6.5) |
subtype4 | 138 | 2.2 (4.7) |
P value = 0.279 (Fisher's exact test), Q value = 0.54
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 11 | 23 | 213 |
subtype1 | 0 | 4 | 11 | 106 |
subtype2 | 1 | 3 | 3 | 43 |
subtype3 | 0 | 4 | 6 | 32 |
subtype4 | 0 | 0 | 3 | 32 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 29 | 32 | 24 |
P value = 0.165 (logrank test), Q value = 0.38
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 85 | 28 | 0.1 - 140.4 (20.3) |
subtype1 | 29 | 13 | 5.1 - 140.4 (12.9) |
subtype2 | 32 | 10 | 0.1 - 100.0 (16.1) |
subtype3 | 24 | 5 | 0.2 - 131.5 (25.7) |
P value = 0.00416 (Kruskal-Wallis (anova)), Q value = 0.027
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 84 | 65.1 (13.0) |
subtype1 | 29 | 68.1 (13.2) |
subtype2 | 32 | 59.5 (13.1) |
subtype3 | 23 | 69.1 (10.3) |
P value = 0.556 (Fisher's exact test), Q value = 0.78
nPatients | STAGE I | STAGE II | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|
ALL | 9 | 6 | 27 | 1 | 1 | 14 | 9 | 9 | 3 |
subtype1 | 2 | 1 | 13 | 1 | 0 | 2 | 2 | 2 | 1 |
subtype2 | 3 | 3 | 7 | 0 | 0 | 7 | 5 | 5 | 2 |
subtype3 | 4 | 2 | 7 | 0 | 1 | 5 | 2 | 2 | 0 |
P value = 0.582 (Fisher's exact test), Q value = 0.78
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 2 | 9 | 63 | 11 |
subtype1 | 1 | 2 | 21 | 5 |
subtype2 | 1 | 2 | 25 | 4 |
subtype3 | 0 | 5 | 17 | 2 |
P value = 0.239 (Fisher's exact test), Q value = 0.48
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 45 | 22 | 18 |
subtype1 | 18 | 4 | 7 |
subtype2 | 13 | 11 | 8 |
subtype3 | 14 | 7 | 3 |
P value = 0.227 (Fisher's exact test), Q value = 0.47
nPatients | 0 | 1 |
---|---|---|
ALL | 56 | 12 |
subtype1 | 18 | 3 |
subtype2 | 18 | 7 |
subtype3 | 20 | 2 |
P value = 0.73 (Fisher's exact test), Q value = 0.87
nPatients | FEMALE | MALE |
---|---|---|
ALL | 38 | 47 |
subtype1 | 14 | 15 |
subtype2 | 15 | 17 |
subtype3 | 9 | 15 |
P value = 0.033 (Fisher's exact test), Q value = 0.16
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 75 | 10 |
subtype1 | 26 | 3 |
subtype2 | 25 | 7 |
subtype3 | 24 | 0 |
P value = 0.487 (Fisher's exact test), Q value = 0.75
nPatients | R0 | RX |
---|---|---|
ALL | 42 | 5 |
subtype1 | 12 | 1 |
subtype2 | 19 | 4 |
subtype3 | 11 | 0 |
P value = 0.0241 (Kruskal-Wallis (anova)), Q value = 0.12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 80 | 2.6 (6.4) |
subtype1 | 29 | 1.7 (3.6) |
subtype2 | 27 | 4.8 (10.0) |
subtype3 | 24 | 1.3 (2.5) |
P value = 0.662 (Fisher's exact test), Q value = 0.82
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 3 | 6 | 73 |
subtype1 | 0 | 0 | 1 | 27 |
subtype2 | 1 | 2 | 3 | 25 |
subtype3 | 0 | 1 | 2 | 21 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 12 | 22 | 17 | 24 | 10 |
P value = 0.603 (logrank test), Q value = 0.78
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 85 | 28 | 0.1 - 140.4 (20.3) |
subtype1 | 12 | 5 | 0.2 - 62.8 (12.8) |
subtype2 | 22 | 7 | 1.4 - 67.3 (18.8) |
subtype3 | 17 | 5 | 0.2 - 131.5 (28.2) |
subtype4 | 24 | 7 | 0.1 - 100.0 (15.4) |
subtype5 | 10 | 4 | 1.3 - 140.4 (13.8) |
P value = 0.589 (Kruskal-Wallis (anova)), Q value = 0.78
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 84 | 65.1 (13.0) |
subtype1 | 12 | 65.1 (14.4) |
subtype2 | 22 | 62.7 (14.6) |
subtype3 | 16 | 67.9 (11.3) |
subtype4 | 24 | 63.7 (13.0) |
subtype5 | 10 | 69.2 (10.6) |
P value = 0.816 (Fisher's exact test), Q value = 0.94
nPatients | STAGE I | STAGE II | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|
ALL | 9 | 6 | 27 | 1 | 1 | 14 | 9 | 9 | 3 |
subtype1 | 1 | 2 | 4 | 1 | 0 | 1 | 1 | 1 | 0 |
subtype2 | 1 | 0 | 4 | 0 | 1 | 6 | 2 | 5 | 2 |
subtype3 | 2 | 2 | 6 | 0 | 0 | 3 | 2 | 1 | 0 |
subtype4 | 4 | 1 | 8 | 0 | 0 | 3 | 3 | 2 | 1 |
subtype5 | 1 | 1 | 5 | 0 | 0 | 1 | 1 | 0 | 0 |
P value = 0.836 (Fisher's exact test), Q value = 0.94
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 2 | 9 | 63 | 11 |
subtype1 | 0 | 1 | 8 | 3 |
subtype2 | 0 | 2 | 19 | 1 |
subtype3 | 1 | 2 | 13 | 1 |
subtype4 | 1 | 3 | 16 | 4 |
subtype5 | 0 | 1 | 7 | 2 |
P value = 0.0757 (Fisher's exact test), Q value = 0.25
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 45 | 22 | 18 |
subtype1 | 9 | 2 | 1 |
subtype2 | 5 | 11 | 6 |
subtype3 | 10 | 4 | 3 |
subtype4 | 14 | 4 | 6 |
subtype5 | 7 | 1 | 2 |
P value = 0.128 (Fisher's exact test), Q value = 0.33
nPatients | 0 | 1 |
---|---|---|
ALL | 56 | 12 |
subtype1 | 6 | 1 |
subtype2 | 12 | 7 |
subtype3 | 14 | 1 |
subtype4 | 16 | 3 |
subtype5 | 8 | 0 |
P value = 0.00115 (Fisher's exact test), Q value = 0.0096
nPatients | FEMALE | MALE |
---|---|---|
ALL | 38 | 47 |
subtype1 | 1 | 11 |
subtype2 | 17 | 5 |
subtype3 | 7 | 10 |
subtype4 | 8 | 16 |
subtype5 | 5 | 5 |
P value = 0.339 (Fisher's exact test), Q value = 0.62
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA |
---|---|---|
ALL | 75 | 10 |
subtype1 | 11 | 1 |
subtype2 | 19 | 3 |
subtype3 | 17 | 0 |
subtype4 | 19 | 5 |
subtype5 | 9 | 1 |
P value = 0.942 (Fisher's exact test), Q value = 1
nPatients | R0 | RX |
---|---|---|
ALL | 42 | 5 |
subtype1 | 7 | 0 |
subtype2 | 14 | 2 |
subtype3 | 4 | 0 |
subtype4 | 13 | 2 |
subtype5 | 4 | 1 |
P value = 0.0469 (Kruskal-Wallis (anova)), Q value = 0.18
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 80 | 2.6 (6.4) |
subtype1 | 12 | 1.2 (3.4) |
subtype2 | 19 | 5.6 (11.5) |
subtype3 | 17 | 1.6 (2.9) |
subtype4 | 22 | 2.3 (4.1) |
subtype5 | 10 | 1.2 (2.4) |
P value = 0.993 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 3 | 6 | 73 |
subtype1 | 0 | 0 | 1 | 10 |
subtype2 | 0 | 1 | 2 | 19 |
subtype3 | 0 | 1 | 2 | 14 |
subtype4 | 1 | 1 | 1 | 21 |
subtype5 | 0 | 0 | 0 | 9 |
-
Cluster data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_mergedClustering/COAD-TP/15098885/COAD-TP.mergedcluster.txt
-
Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/COAD-TP/15076851/COAD-TP.merged_data.txt
-
Number of patients = 452
-
Number of clustering approaches = 12
-
Number of selected clinical features = 12
-
Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.