This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.
Testing the association between mutation status of 64 genes and 13 clinical features across 506 patients, 8 significant findings detected with Q value < 0.25.
-
NSD1 mutation correlated to 'NUMBER_OF_LYMPH_NODES'.
-
CASP8 mutation correlated to 'YEARS_TO_BIRTH' and 'GENDER'.
-
FAT1 mutation correlated to 'YEARS_TO_BIRTH'.
-
RAC1 mutation correlated to 'YEARS_TO_BIRTH'.
-
NAP1L2 mutation correlated to 'ETHNICITY'.
-
CTCF mutation correlated to 'YEARS_TO_BIRTH'.
-
SLC9A6 mutation correlated to 'Time to Death'.
Clinical Features |
Time to Death |
YEARS TO BIRTH |
NEOPLASM DISEASESTAGE |
PATHOLOGY T STAGE |
PATHOLOGY N STAGE |
GENDER |
HISTOLOGICAL TYPE |
RADIATIONS RADIATION REGIMENINDICATION |
NUMBER PACK YEARS SMOKED |
YEAR OF TOBACCO SMOKING ONSET |
NUMBER OF LYMPH NODES |
RACE | ETHNICITY | ||
nMutated (%) | nWild-Type | logrank test | Wilcoxon-test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Wilcoxon-test | Wilcoxon-test | Wilcoxon-test | Fisher's exact test | Fisher's exact test | |
CASP8 | 54 (11%) | 452 |
0.0264 (0.61) |
6.46e-09 (5.38e-06) |
0.889 (1.00) |
0.399 (1.00) |
0.0667 (0.73) |
0.000286 (0.0646) |
1 (1.00) |
0.173 (0.924) |
0.111 (0.888) |
0.0162 (0.465) |
0.0171 (0.473) |
0.724 (1.00) |
0.506 (1.00) |
NSD1 | 63 (12%) | 443 |
0.0308 (0.627) |
0.039 (0.627) |
0.115 (0.888) |
0.571 (1.00) |
0.038 (0.627) |
0.0696 (0.732) |
1 (1.00) |
0.145 (0.888) |
0.0977 (0.854) |
0.6 (1.00) |
0.000311 (0.0646) |
0.676 (1.00) |
0.217 (0.955) |
FAT1 | 113 (22%) | 393 |
0.665 (1.00) |
1.43e-06 (0.000597) |
0.787 (1.00) |
0.0406 (0.627) |
0.328 (1.00) |
0.0118 (0.392) |
1 (1.00) |
1 (1.00) |
0.144 (0.888) |
0.0216 (0.528) |
0.35 (1.00) |
0.598 (1.00) |
0.455 (1.00) |
RAC1 | 15 (3%) | 491 |
0.475 (1.00) |
0.00119 (0.165) |
0.221 (0.968) |
0.188 (0.937) |
0.404 (1.00) |
0.0074 (0.342) |
1 (1.00) |
1 (1.00) |
0.738 (1.00) |
0.00521 (0.31) |
0.19 (0.937) |
0.307 (1.00) |
1 (1.00) |
NAP1L2 | 7 (1%) | 499 |
0.698 (1.00) |
0.909 (1.00) |
0.258 (0.999) |
0.668 (1.00) |
0.148 (0.888) |
1 (1.00) |
0.105 (0.883) |
1 (1.00) |
0.581 (1.00) |
0.863 (1.00) |
0.461 (1.00) |
0.47 (1.00) |
0.0024 (0.25) |
CTCF | 16 (3%) | 490 |
0.0704 (0.732) |
0.00103 (0.165) |
0.141 (0.888) |
1 (1.00) |
0.45 (1.00) |
0.049 (0.668) |
1 (1.00) |
0.313 (1.00) |
0.709 (1.00) |
0.0438 (0.627) |
0.32 (1.00) |
0.429 (1.00) |
1 (1.00) |
SLC9A6 | 5 (1%) | 501 |
0.00166 (0.198) |
0.796 (1.00) |
0.322 (1.00) |
0.464 (1.00) |
0.129 (0.888) |
0.13 (0.888) |
1 (1.00) |
0.593 (1.00) |
0.861 (1.00) |
0.142 (0.888) |
1 (1.00) |
1 (1.00) |
|
TP53 | 356 (70%) | 150 |
0.00493 (0.31) |
0.264 (0.999) |
0.52 (1.00) |
0.0275 (0.619) |
0.659 (1.00) |
0.828 (1.00) |
0.00331 (0.296) |
0.361 (1.00) |
0.0834 (0.797) |
0.861 (1.00) |
0.643 (1.00) |
0.61 (1.00) |
0.123 (0.888) |
CDKN2A | 110 (22%) | 396 |
0.718 (1.00) |
0.143 (0.888) |
0.317 (1.00) |
0.692 (1.00) |
0.664 (1.00) |
0.904 (1.00) |
0.497 (1.00) |
0.149 (0.888) |
0.392 (1.00) |
0.487 (1.00) |
0.43 (1.00) |
0.573 (1.00) |
0.469 (1.00) |
PIK3CA | 94 (19%) | 412 |
0.548 (1.00) |
0.691 (1.00) |
0.459 (1.00) |
0.306 (1.00) |
0.197 (0.941) |
0.0408 (0.627) |
0.478 (1.00) |
0.644 (1.00) |
0.839 (1.00) |
0.67 (1.00) |
0.346 (1.00) |
0.0326 (0.627) |
1 (1.00) |
HRAS | 28 (6%) | 478 |
0.546 (1.00) |
0.385 (1.00) |
0.45 (1.00) |
0.939 (1.00) |
0.133 (0.888) |
0.0795 (0.778) |
1 (1.00) |
0.0656 (0.727) |
0.971 (1.00) |
0.623 (1.00) |
0.119 (0.888) |
0.564 (1.00) |
0.387 (1.00) |
TGFBR2 | 23 (5%) | 483 |
0.704 (1.00) |
0.059 (0.707) |
0.861 (1.00) |
0.718 (1.00) |
0.549 (1.00) |
1 (1.00) |
1 (1.00) |
0.0211 (0.528) |
0.344 (1.00) |
0.0948 (0.839) |
0.407 (1.00) |
0.589 (1.00) |
1 (1.00) |
NOTCH1 | 86 (17%) | 420 |
0.298 (1.00) |
0.008 (0.343) |
0.947 (1.00) |
0.426 (1.00) |
0.487 (1.00) |
0.0629 (0.707) |
0.675 (1.00) |
0.873 (1.00) |
0.122 (0.888) |
0.215 (0.955) |
0.198 (0.941) |
0.927 (1.00) |
0.177 (0.924) |
EPHA2 | 23 (5%) | 483 |
0.254 (0.999) |
0.126 (0.888) |
0.827 (1.00) |
0.669 (1.00) |
0.168 (0.924) |
0.474 (1.00) |
1 (1.00) |
1 (1.00) |
0.0559 (0.707) |
0.152 (0.888) |
0.94 (1.00) |
0.399 (1.00) |
1 (1.00) |
HLA-B | 24 (5%) | 482 |
0.778 (1.00) |
0.197 (0.941) |
0.736 (1.00) |
0.363 (1.00) |
0.0385 (0.627) |
0.157 (0.888) |
0.325 (1.00) |
0.021 (0.528) |
0.245 (0.999) |
0.152 (0.888) |
0.304 (1.00) |
0.517 (1.00) |
0.614 (1.00) |
NFE2L2 | 26 (5%) | 480 |
0.126 (0.888) |
0.00391 (0.296) |
0.789 (1.00) |
0.813 (1.00) |
0.594 (1.00) |
0.112 (0.888) |
1 (1.00) |
0.285 (1.00) |
0.674 (1.00) |
0.216 (0.955) |
0.343 (1.00) |
0.308 (1.00) |
0.329 (1.00) |
ZNF750 | 19 (4%) | 487 |
0.939 (1.00) |
0.372 (1.00) |
0.301 (1.00) |
0.723 (1.00) |
0.557 (1.00) |
0.304 (1.00) |
1 (1.00) |
0.752 (1.00) |
0.47 (1.00) |
0.529 (1.00) |
0.0718 (0.737) |
0.407 (1.00) |
0.614 (1.00) |
PTEN | 14 (3%) | 492 |
0.184 (0.937) |
0.318 (1.00) |
0.936 (1.00) |
0.301 (1.00) |
0.494 (1.00) |
1 (1.00) |
1 (1.00) |
0.484 (1.00) |
0.419 (1.00) |
0.167 (0.924) |
0.516 (1.00) |
0.736 (1.00) |
1 (1.00) |
HLA-A | 22 (4%) | 484 |
0.967 (1.00) |
0.0901 (0.821) |
0.901 (1.00) |
0.0894 (0.821) |
0.309 (1.00) |
1 (1.00) |
1 (1.00) |
0.77 (1.00) |
0.209 (0.947) |
0.0144 (0.444) |
0.742 (1.00) |
0.813 (1.00) |
0.614 (1.00) |
RB1 | 17 (3%) | 489 |
0.144 (0.888) |
0.56 (1.00) |
0.147 (0.888) |
0.247 (0.999) |
0.736 (1.00) |
0.00952 (0.345) |
1 (1.00) |
1 (1.00) |
0.661 (1.00) |
0.315 (1.00) |
0.33 (1.00) |
0.358 (1.00) |
1 (1.00) |
MAPK1 | 9 (2%) | 497 |
0.261 (0.999) |
0.95 (1.00) |
0.868 (1.00) |
0.429 (1.00) |
0.652 (1.00) |
0.711 (1.00) |
1 (1.00) |
0.367 (1.00) |
0.427 (1.00) |
0.886 (1.00) |
0.235 (0.987) |
1 (1.00) |
|
KDM6A | 17 (3%) | 489 |
0.399 (1.00) |
0.0546 (0.707) |
0.418 (1.00) |
0.256 (0.999) |
0.848 (1.00) |
1 (1.00) |
1 (1.00) |
0.33 (1.00) |
0.151 (0.888) |
0.203 (0.947) |
0.909 (1.00) |
0.285 (1.00) |
1 (1.00) |
EP300 | 39 (8%) | 467 |
0.377 (1.00) |
0.731 (1.00) |
0.909 (1.00) |
0.723 (1.00) |
0.513 (1.00) |
0.455 (1.00) |
1 (1.00) |
0.656 (1.00) |
0.258 (0.999) |
0.692 (1.00) |
0.823 (1.00) |
0.741 (1.00) |
0.435 (1.00) |
RASA1 | 17 (3%) | 489 |
0.991 (1.00) |
0.781 (1.00) |
0.671 (1.00) |
0.436 (1.00) |
0.957 (1.00) |
0.423 (1.00) |
1 (1.00) |
0.0442 (0.627) |
0.407 (1.00) |
0.944 (1.00) |
0.757 (1.00) |
1 (1.00) |
0.227 (0.973) |
CREBBP | 35 (7%) | 471 |
0.247 (0.999) |
0.0338 (0.627) |
0.689 (1.00) |
0.73 (1.00) |
0.886 (1.00) |
0.562 (1.00) |
0.438 (1.00) |
0.242 (0.998) |
0.712 (1.00) |
0.0483 (0.668) |
0.642 (1.00) |
0.161 (0.907) |
1 (1.00) |
KEAP1 | 22 (4%) | 484 |
0.994 (1.00) |
0.0986 (0.854) |
0.11 (0.888) |
0.00884 (0.343) |
0.384 (1.00) |
0.15 (0.888) |
0.043 (0.627) |
0.0699 (0.732) |
0.0937 (0.838) |
0.365 (1.00) |
0.827 (1.00) |
0.48 (1.00) |
0.614 (1.00) |
RHOA | 10 (2%) | 496 |
0.318 (1.00) |
0.396 (1.00) |
1 (1.00) |
0.416 (1.00) |
0.0327 (0.627) |
0.473 (1.00) |
0.148 (0.888) |
0.38 (1.00) |
0.707 (1.00) |
0.633 (1.00) |
0.32 (1.00) |
1 (1.00) |
1 (1.00) |
FBXW7 | 33 (7%) | 473 |
0.344 (1.00) |
0.0066 (0.331) |
0.702 (1.00) |
0.404 (1.00) |
0.36 (1.00) |
0.156 (0.888) |
1 (1.00) |
0.631 (1.00) |
0.315 (1.00) |
0.857 (1.00) |
0.187 (0.937) |
0.882 (1.00) |
0.661 (1.00) |
TIGD4 | 7 (1%) | 499 |
0.312 (1.00) |
0.177 (0.924) |
0.268 (0.999) |
0.779 (1.00) |
0.19 (0.937) |
0.68 (1.00) |
1 (1.00) |
0.606 (1.00) |
0.506 (1.00) |
0.454 (1.00) |
0.178 (0.924) |
0.527 (1.00) |
1 (1.00) |
KRT5 | 11 (2%) | 495 |
0.618 (1.00) |
0.262 (0.999) |
0.0539 (0.707) |
0.241 (0.998) |
0.738 (1.00) |
0.504 (1.00) |
1 (1.00) |
0.699 (1.00) |
0.0115 (0.392) |
0.0083 (0.343) |
0.532 (1.00) |
0.261 (0.999) |
1 (1.00) |
SMAD4 | 14 (3%) | 492 |
0.485 (1.00) |
0.42 (1.00) |
0.684 (1.00) |
1 (1.00) |
0.683 (1.00) |
0.767 (1.00) |
1 (1.00) |
0.711 (1.00) |
0.423 (1.00) |
0.192 (0.939) |
0.884 (1.00) |
1 (1.00) |
1 (1.00) |
ASXL1 | 16 (3%) | 490 |
0.239 (0.998) |
0.842 (1.00) |
0.513 (1.00) |
0.171 (0.924) |
0.138 (0.888) |
0.777 (1.00) |
1 (1.00) |
1 (1.00) |
0.936 (1.00) |
0.717 (1.00) |
0.814 (1.00) |
0.577 (1.00) |
1 (1.00) |
CES2 | 11 (2%) | 495 |
0.991 (1.00) |
0.843 (1.00) |
0.617 (1.00) |
0.533 (1.00) |
1 (1.00) |
0.504 (1.00) |
1 (1.00) |
1 (1.00) |
0.579 (1.00) |
0.63 (1.00) |
0.82 (1.00) |
0.0605 (0.707) |
1 (1.00) |
IRS4 | 17 (3%) | 489 |
0.938 (1.00) |
0.931 (1.00) |
0.71 (1.00) |
0.761 (1.00) |
0.421 (1.00) |
0.266 (0.999) |
1 (1.00) |
1 (1.00) |
0.836 (1.00) |
0.986 (1.00) |
0.153 (0.888) |
0.546 (1.00) |
0.187 (0.937) |
ARID2 | 20 (4%) | 486 |
0.25 (0.999) |
0.869 (1.00) |
0.868 (1.00) |
0.478 (1.00) |
0.771 (1.00) |
0.448 (1.00) |
1 (1.00) |
0.223 (0.968) |
0.209 (0.947) |
0.326 (1.00) |
0.208 (0.947) |
0.224 (0.968) |
0.268 (0.999) |
CBWD1 | 5 (1%) | 501 |
0.00907 (0.343) |
0.201 (0.947) |
1 (1.00) |
0.918 (1.00) |
0.688 (1.00) |
0.329 (1.00) |
1 (1.00) |
0.593 (1.00) |
0.312 (1.00) |
1 (1.00) |
1 (1.00) |
||
RGL4 | 7 (1%) | 499 |
0.123 (0.888) |
0.554 (1.00) |
0.00677 (0.331) |
0.0194 (0.521) |
0.331 (1.00) |
0.4 (1.00) |
1 (1.00) |
0.606 (1.00) |
0.325 (1.00) |
0.389 (1.00) |
0.0358 (0.627) |
0.523 (1.00) |
1 (1.00) |
HUWE1 | 45 (9%) | 461 |
0.206 (0.947) |
0.346 (1.00) |
0.913 (1.00) |
0.559 (1.00) |
0.441 (1.00) |
0.0237 (0.563) |
1 (1.00) |
0.402 (1.00) |
0.374 (1.00) |
0.463 (1.00) |
0.568 (1.00) |
0.0765 (0.767) |
0.271 (1.00) |
HNRNPL | 11 (2%) | 495 |
0.592 (1.00) |
0.0392 (0.627) |
0.278 (1.00) |
0.427 (1.00) |
0.102 (0.875) |
0.184 (0.937) |
1 (1.00) |
0.699 (1.00) |
0.545 (1.00) |
0.657 (1.00) |
0.217 (0.955) |
1 (1.00) |
1 (1.00) |
ITGB1 | 14 (3%) | 492 |
0.575 (1.00) |
0.12 (0.888) |
0.134 (0.888) |
0.144 (0.888) |
0.383 (1.00) |
1 (1.00) |
1 (1.00) |
0.484 (1.00) |
0.7 (1.00) |
0.973 (1.00) |
0.562 (1.00) |
1 (1.00) |
0.54 (1.00) |
B2M | 7 (1%) | 499 |
0.605 (1.00) |
0.934 (1.00) |
0.744 (1.00) |
1 (1.00) |
0.436 (1.00) |
1 (1.00) |
1 (1.00) |
0.606 (1.00) |
0.087 (0.821) |
0.729 (1.00) |
0.0338 (0.627) |
1 (1.00) |
1 (1.00) |
LRRC37B | 16 (3%) | 490 |
0.471 (1.00) |
0.913 (1.00) |
0.969 (1.00) |
0.881 (1.00) |
0.699 (1.00) |
0.395 (1.00) |
0.231 (0.981) |
1 (1.00) |
0.306 (1.00) |
0.587 (1.00) |
0.933 (1.00) |
1 (1.00) |
1 (1.00) |
PPFIA4 | 14 (3%) | 492 |
0.397 (1.00) |
0.859 (1.00) |
0.472 (1.00) |
0.519 (1.00) |
0.0406 (0.627) |
0.225 (0.968) |
1 (1.00) |
0.711 (1.00) |
0.428 (1.00) |
0.696 (1.00) |
0.0043 (0.298) |
1 (1.00) |
1 (1.00) |
PIK3R1 | 9 (2%) | 497 |
0.0445 (0.627) |
0.8 (1.00) |
0.521 (1.00) |
0.801 (1.00) |
0.157 (0.888) |
0.455 (1.00) |
1 (1.00) |
1 (1.00) |
0.775 (1.00) |
0.888 (1.00) |
0.178 (0.924) |
1 (1.00) |
1 (1.00) |
VPS33B | 7 (1%) | 499 |
0.914 (1.00) |
0.117 (0.888) |
0.173 (0.924) |
0.881 (1.00) |
0.0808 (0.781) |
0.4 (1.00) |
0.104 (0.88) |
1 (1.00) |
0.651 (1.00) |
0.421 (1.00) |
0.688 (1.00) |
0.523 (1.00) |
1 (1.00) |
C8ORF31 | 4 (1%) | 502 |
0.651 (1.00) |
0.195 (0.941) |
0.871 (1.00) |
0.597 (1.00) |
1 (1.00) |
1 (1.00) |
0.513 (1.00) |
0.946 (1.00) |
0.637 (1.00) |
1 (1.00) |
1 (1.00) |
||
NCOR1 | 18 (4%) | 488 |
0.975 (1.00) |
0.276 (1.00) |
0.752 (1.00) |
0.531 (1.00) |
0.737 (1.00) |
0.594 (1.00) |
1 (1.00) |
0.332 (1.00) |
0.702 (1.00) |
0.426 (1.00) |
0.362 (1.00) |
0.78 (1.00) |
0.247 (0.999) |
SEH1L | 4 (1%) | 502 |
0.92 (1.00) |
0.587 (1.00) |
0.744 (1.00) |
1 (1.00) |
0.19 (0.937) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.0358 (0.627) |
0.13 (0.888) |
1 (1.00) |
||
CUL3 | 14 (3%) | 492 |
0.457 (1.00) |
0.262 (0.999) |
0.169 (0.924) |
0.0422 (0.627) |
0.618 (1.00) |
0.369 (1.00) |
1 (1.00) |
0.0624 (0.707) |
0.713 (1.00) |
0.171 (0.924) |
0.212 (0.952) |
0.18 (0.93) |
1 (1.00) |
NOTCH2 | 19 (4%) | 487 |
0.946 (1.00) |
0.109 (0.888) |
0.259 (0.999) |
0.751 (1.00) |
0.565 (1.00) |
0.00632 (0.331) |
1 (1.00) |
0.532 (1.00) |
0.303 (1.00) |
0.15 (0.888) |
0.425 (1.00) |
1 (1.00) |
0.614 (1.00) |
YTHDF1 | 6 (1%) | 500 |
0.031 (0.627) |
0.475 (1.00) |
0.904 (1.00) |
0.348 (1.00) |
0.88 (1.00) |
0.668 (1.00) |
0.0908 (0.821) |
0.256 (0.999) |
0.338 (1.00) |
0.689 (1.00) |
0.704 (1.00) |
1 (1.00) |
1 (1.00) |
FOSL2 | 10 (2%) | 496 |
0.00384 (0.296) |
0.878 (1.00) |
0.729 (1.00) |
0.959 (1.00) |
0.881 (1.00) |
0.147 (0.888) |
1 (1.00) |
0.672 (1.00) |
0.646 (1.00) |
0.969 (1.00) |
0.0619 (0.707) |
1 (1.00) |
1 (1.00) |
MYH9 | 22 (4%) | 484 |
0.612 (1.00) |
0.607 (1.00) |
0.86 (1.00) |
0.964 (1.00) |
0.759 (1.00) |
0.464 (1.00) |
0.301 (1.00) |
1 (1.00) |
0.438 (1.00) |
0.369 (1.00) |
0.61 (1.00) |
0.529 (1.00) |
0.268 (0.999) |
TP63 | 12 (2%) | 494 |
0.137 (0.888) |
0.797 (1.00) |
0.33 (1.00) |
0.576 (1.00) |
0.526 (1.00) |
0.744 (1.00) |
1 (1.00) |
0.117 (0.888) |
0.606 (1.00) |
0.652 (1.00) |
0.198 (0.941) |
1 (1.00) |
1 (1.00) |
DYSF | 21 (4%) | 485 |
0.771 (1.00) |
0.0548 (0.707) |
0.973 (1.00) |
0.692 (1.00) |
0.115 (0.888) |
1 (1.00) |
1 (1.00) |
0.763 (1.00) |
0.0571 (0.707) |
0.114 (0.888) |
0.0783 (0.775) |
1 (1.00) |
0.616 (1.00) |
TMEM2 | 17 (3%) | 489 |
0.792 (1.00) |
0.854 (1.00) |
0.07 (0.732) |
0.2 (0.944) |
0.278 (1.00) |
0.789 (1.00) |
1 (1.00) |
0.0442 (0.627) |
0.978 (1.00) |
0.909 (1.00) |
0.509 (1.00) |
1 (1.00) |
0.54 (1.00) |
PTPN14 | 14 (3%) | 492 |
0.123 (0.888) |
0.976 (1.00) |
0.367 (1.00) |
0.566 (1.00) |
0.26 (0.999) |
1 (1.00) |
1 (1.00) |
0.0624 (0.707) |
0.404 (1.00) |
0.514 (1.00) |
0.408 (1.00) |
0.0739 (0.75) |
0.54 (1.00) |
RBM10 | 4 (1%) | 502 |
0.415 (1.00) |
0.837 (1.00) |
1 (1.00) |
0.535 (1.00) |
0.69 (1.00) |
1 (1.00) |
1 (1.00) |
0.128 (0.888) |
0.525 (1.00) |
1 (1.00) |
0.0153 (0.454) |
||
IRF2 | 7 (1%) | 499 |
0.298 (1.00) |
0.605 (1.00) |
0.781 (1.00) |
0.465 (1.00) |
0.673 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.155 (0.888) |
0.0587 (0.707) |
0.831 (1.00) |
1 (1.00) |
1 (1.00) |
AMPD1 | 6 (1%) | 500 |
0.367 (1.00) |
0.998 (1.00) |
0.797 (1.00) |
0.919 (1.00) |
1 (1.00) |
0.668 (1.00) |
1 (1.00) |
1 (1.00) |
0.231 (0.981) |
0.177 (0.924) |
0.91 (1.00) |
1 (1.00) |
1 (1.00) |
ZMYM1 | 9 (2%) | 497 |
0.0624 (0.707) |
0.782 (1.00) |
0.664 (1.00) |
0.782 (1.00) |
0.529 (1.00) |
0.711 (1.00) |
1 (1.00) |
0.646 (1.00) |
0.206 (0.947) |
0.891 (1.00) |
0.442 (1.00) |
1 (1.00) |
1 (1.00) |
LCP1 | 15 (3%) | 491 |
0.737 (1.00) |
0.659 (1.00) |
0.275 (1.00) |
0.0899 (0.821) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.285 (1.00) |
0.667 (1.00) |
0.393 (1.00) |
0.628 (1.00) |
0.727 (1.00) |
0.565 (1.00) |
CCNG2 | 3 (1%) | 503 |
0.668 (1.00) |
0.235 (0.987) |
0.48 (1.00) |
1 (1.00) |
0.416 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.139 (0.888) |
0.0405 (0.627) |
0.0134 (0.428) |
1 (1.00) |
|
TACR2 | 4 (1%) | 502 |
0.209 (0.947) |
0.671 (1.00) |
0.745 (1.00) |
1 (1.00) |
0.419 (1.00) |
0.579 (1.00) |
1 (1.00) |
0.513 (1.00) |
0.994 (1.00) |
0.242 (0.998) |
1 (1.00) |
1 (1.00) |
P value = 0.000311 (Wilcoxon-test), Q value = 0.065
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 396 | 2.2 (4.3) |
NSD1 MUTATED | 47 | 0.8 (1.5) |
NSD1 WILD-TYPE | 349 | 2.4 (4.6) |
P value = 6.46e-09 (Wilcoxon-test), Q value = 5.4e-06
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 506 | 61.0 (12.0) |
CASP8 MUTATED | 54 | 70.2 (13.4) |
CASP8 WILD-TYPE | 452 | 59.9 (11.4) |
P value = 0.000286 (Fisher's exact test), Q value = 0.065
nPatients | FEMALE | MALE |
---|---|---|
ALL | 139 | 367 |
CASP8 MUTATED | 27 | 27 |
CASP8 WILD-TYPE | 112 | 340 |
P value = 1.43e-06 (Wilcoxon-test), Q value = 6e-04
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 506 | 61.0 (12.0) |
FAT1 MUTATED | 113 | 66.0 (11.4) |
FAT1 WILD-TYPE | 393 | 59.6 (11.8) |
P value = 0.00119 (Wilcoxon-test), Q value = 0.16
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 506 | 61.0 (12.0) |
RAC1 MUTATED | 15 | 70.8 (12.6) |
RAC1 WILD-TYPE | 491 | 60.7 (11.9) |
P value = 0.0024 (Fisher's exact test), Q value = 0.25
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 25 | 445 |
NAP1L2 MUTATED | 3 | 3 |
NAP1L2 WILD-TYPE | 22 | 442 |
P value = 0.00103 (Wilcoxon-test), Q value = 0.16
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 506 | 61.0 (12.0) |
CTCF MUTATED | 16 | 71.2 (11.1) |
CTCF WILD-TYPE | 490 | 60.7 (11.9) |
P value = 0.00166 (logrank test), Q value = 0.2
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 504 | 201 | 0.1 - 211.0 (18.7) |
SLC9A6 MUTATED | 5 | 4 | 6.1 - 16.0 (13.1) |
SLC9A6 WILD-TYPE | 499 | 197 | 0.1 - 211.0 (18.8) |
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Mutation data file = sample_sig_gene_table.txt from Mutsig_2CV pipeline
-
Processed Mutation data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/HNSC-TP/15648706/transformed.cor.cli.txt
-
Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/HNSC-TP/15078978/HNSC-TP.merged_data.txt
-
Number of patients = 506
-
Number of significantly mutated genes = 64
-
Number of selected clinical features = 13
-
Exclude genes that fewer than K tumors have mutations, K = 3
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.