This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 10 different clustering approaches and 17 clinical features across 501 patients, 84 significant findings detected with P value < 0.05 and Q value < 0.25.
-
3 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes correlate to 'YEARS_TO_BIRTH', 'NEOPLASM_DISEASESTAGE', 'MULTIFOCALITY', and 'TUMOR_SIZE'.
-
3 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes correlate to 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'EXTRATHYROIDAL_EXTENSION', and 'NUMBER_OF_LYMPH_NODES'.
-
CNMF clustering analysis on RPPA data identified 3 subtypes that correlate to 'YEARS_TO_BIRTH', 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'RADIATIONS_RADIATION_REGIMENINDICATION', 'EXTRATHYROIDAL_EXTENSION', and 'MULTIFOCALITY'.
-
Consensus hierarchical clustering analysis on RPPA data identified 7 subtypes that correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'EXTRATHYROIDAL_EXTENSION', and 'TUMOR_SIZE'.
-
CNMF clustering analysis on sequencing-based mRNA expression data identified 4 subtypes that correlate to 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'RADIATIONS_RADIATION_REGIMENINDICATION', 'EXTRATHYROIDAL_EXTENSION', 'NUMBER_OF_LYMPH_NODES', 'TUMOR_SIZE', and 'ETHNICITY'.
-
Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 5 subtypes that correlate to 'YEARS_TO_BIRTH', 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'EXTRATHYROIDAL_EXTENSION', 'COMPLETENESS_OF_RESECTION', 'NUMBER_OF_LYMPH_NODES', 'TUMOR_SIZE', 'RACE', and 'ETHNICITY'.
-
3 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes correlate to 'Time to Death', 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'EXTRATHYROIDAL_EXTENSION', 'NUMBER_OF_LYMPH_NODES', and 'TUMOR_SIZE'.
-
3 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'RADIATIONS_RADIATION_REGIMENINDICATION', 'EXTRATHYROIDAL_EXTENSION', 'NUMBER_OF_LYMPH_NODES', and 'TUMOR_SIZE'.
-
3 subtypes identified in current cancer cohort by 'MIRseq Mature CNMF subtypes'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'RADIATIONS_RADIATION_REGIMENINDICATION', 'EXTRATHYROIDAL_EXTENSION', 'COMPLETENESS_OF_RESECTION', 'NUMBER_OF_LYMPH_NODES', and 'RACE'.
-
3 subtypes identified in current cancer cohort by 'MIRseq Mature cHierClus subtypes'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'EXTRATHYROIDAL_EXTENSION', 'NUMBER_OF_LYMPH_NODES', and 'TUMOR_SIZE'.
Clinical Features |
Statistical Tests |
Copy Number Ratio CNMF subtypes |
METHLYATION CNMF |
RPPA CNMF subtypes |
RPPA cHierClus subtypes |
RNAseq CNMF subtypes |
RNAseq cHierClus subtypes |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRseq Mature CNMF subtypes |
MIRseq Mature cHierClus subtypes |
Time to Death | logrank test |
0.396 (0.539) |
0.247 (0.366) |
0.586 (0.73) |
0.00158 (0.00479) |
0.526 (0.677) |
0.677 (0.788) |
0.0239 (0.0534) |
0.0135 (0.0333) |
0.0198 (0.0472) |
0.0037 (0.0103) |
YEARS TO BIRTH | Kruskal-Wallis (anova) |
6.72e-08 (1.71e-06) |
0.171 (0.285) |
0.00134 (0.00423) |
0.000999 (0.00333) |
0.157 (0.268) |
0.00242 (0.00697) |
0.0512 (0.102) |
0.000963 (0.00327) |
0.0201 (0.0472) |
0.00018 (0.000665) |
NEOPLASM DISEASESTAGE | Fisher's exact test |
2e-05 (8.95e-05) |
3e-05 (0.000127) |
0.00167 (0.00498) |
0.00104 (0.0034) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
PATHOLOGY T STAGE | Fisher's exact test |
0.108 (0.195) |
0.00188 (0.00551) |
0.00356 (0.0101) |
0.00013 (0.000491) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
7e-05 (0.000277) |
5e-05 (0.000202) |
8e-05 (0.000309) |
3e-05 (0.000127) |
PATHOLOGY N STAGE | Fisher's exact test |
0.908 (0.965) |
1e-05 (4.59e-05) |
0.0309 (0.0663) |
0.00882 (0.0231) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
0.00083 (0.00288) |
1e-05 (4.59e-05) |
PATHOLOGY M STAGE | Fisher's exact test |
0.6 (0.739) |
0.639 (0.765) |
0.524 (0.677) |
0.757 (0.847) |
0.755 (0.847) |
0.393 (0.539) |
0.461 (0.603) |
0.335 (0.479) |
0.436 (0.575) |
0.369 (0.519) |
GENDER | Fisher's exact test |
0.387 (0.534) |
0.949 (0.978) |
0.656 (0.769) |
0.942 (0.978) |
0.878 (0.958) |
0.169 (0.284) |
0.883 (0.958) |
0.646 (0.765) |
0.956 (0.978) |
0.184 (0.304) |
HISTOLOGICAL TYPE | Fisher's exact test |
0.702 (0.8) |
1e-05 (4.59e-05) |
4e-05 (0.000166) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
RADIATIONS RADIATION REGIMENINDICATION | Fisher's exact test |
0.62 (0.753) |
0.117 (0.207) |
0.0104 (0.0261) |
0.19 (0.307) |
0.00568 (0.0153) |
0.0733 (0.142) |
0.193 (0.307) |
0.00952 (0.0245) |
0.00019 (0.000687) |
0.105 (0.191) |
RADIATION EXPOSURE | Fisher's exact test |
0.576 (0.73) |
0.648 (0.765) |
1 (1.00) |
0.236 (0.358) |
0.984 (0.995) |
0.254 (0.373) |
0.951 (0.978) |
0.906 (0.965) |
0.431 (0.575) |
0.854 (0.943) |
EXTRATHYROIDAL EXTENSION | Fisher's exact test |
0.0564 (0.11) |
1e-05 (4.59e-05) |
0.00073 (0.00259) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
1e-05 (4.59e-05) |
COMPLETENESS OF RESECTION | Fisher's exact test |
0.0834 (0.157) |
0.238 (0.358) |
0.277 (0.399) |
0.0938 (0.173) |
0.156 (0.267) |
0.0209 (0.0481) |
0.19 (0.307) |
0.203 (0.316) |
0.032 (0.0673) |
0.0516 (0.102) |
NUMBER OF LYMPH NODES | Kruskal-Wallis (anova) |
0.617 (0.753) |
2.12e-08 (7.2e-07) |
0.431 (0.575) |
0.375 (0.523) |
8.57e-09 (3.75e-07) |
8.83e-09 (3.75e-07) |
6.95e-09 (3.75e-07) |
2.21e-09 (3.75e-07) |
0.00995 (0.0252) |
7.02e-08 (1.71e-06) |
MULTIFOCALITY | Fisher's exact test |
0.0289 (0.0631) |
0.942 (0.978) |
0.0143 (0.0348) |
0.117 (0.207) |
0.236 (0.358) |
0.225 (0.348) |
0.885 (0.958) |
0.589 (0.73) |
0.905 (0.965) |
0.583 (0.73) |
TUMOR SIZE | Kruskal-Wallis (anova) |
0.00509 (0.014) |
0.57 (0.729) |
0.711 (0.806) |
0.0203 (0.0472) |
0.0384 (0.0786) |
0.00154 (0.00474) |
0.0233 (0.0527) |
0.0352 (0.0729) |
0.128 (0.224) |
0.0271 (0.0599) |
RACE | Fisher's exact test |
0.2 (0.314) |
0.645 (0.765) |
0.0808 (0.154) |
0.277 (0.399) |
0.701 (0.8) |
0.00114 (0.00366) |
0.357 (0.505) |
0.192 (0.307) |
0.0406 (0.0822) |
0.0874 (0.163) |
ETHNICITY | Fisher's exact test |
0.96 (0.978) |
0.433 (0.575) |
0.146 (0.253) |
0.937 (0.978) |
0.00686 (0.0182) |
0.0312 (0.0663) |
0.698 (0.8) |
0.777 (0.864) |
1 (1.00) |
0.247 (0.366) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 56 | 355 | 88 |
P value = 0.396 (logrank test), Q value = 0.54
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 497 | 14 | 0.1 - 169.3 (20.4) |
subtype1 | 55 | 3 | 1.0 - 136.0 (22.3) |
subtype2 | 354 | 10 | 0.1 - 169.3 (21.0) |
subtype3 | 88 | 1 | 0.3 - 139.9 (16.7) |
P value = 6.72e-08 (Kruskal-Wallis (anova)), Q value = 1.7e-06
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 499 | 47.2 (15.8) |
subtype1 | 56 | 58.7 (14.7) |
subtype2 | 355 | 45.3 (15.6) |
subtype3 | 88 | 47.4 (14.2) |
P value = 2e-05 (Fisher's exact test), Q value = 8.9e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 282 | 52 | 109 | 2 | 46 | 6 |
subtype1 | 14 | 14 | 16 | 1 | 10 | 1 |
subtype2 | 215 | 32 | 77 | 0 | 26 | 4 |
subtype3 | 53 | 6 | 16 | 1 | 10 | 1 |
P value = 0.108 (Fisher's exact test), Q value = 0.2
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 141 | 166 | 167 | 23 |
subtype1 | 8 | 21 | 22 | 5 |
subtype2 | 103 | 114 | 121 | 15 |
subtype3 | 30 | 31 | 24 | 3 |
P value = 0.908 (Fisher's exact test), Q value = 0.96
nPatients | 0 | 1 |
---|---|---|
ALL | 224 | 225 |
subtype1 | 24 | 23 |
subtype2 | 157 | 162 |
subtype3 | 43 | 40 |
P value = 0.6 (Fisher's exact test), Q value = 0.74
nPatients | 0 | 1 |
---|---|---|
ALL | 277 | 9 |
subtype1 | 24 | 1 |
subtype2 | 204 | 6 |
subtype3 | 49 | 2 |
P value = 0.387 (Fisher's exact test), Q value = 0.53
nPatients | FEMALE | MALE |
---|---|---|
ALL | 366 | 133 |
subtype1 | 37 | 19 |
subtype2 | 265 | 90 |
subtype3 | 64 | 24 |
P value = 0.702 (Fisher's exact test), Q value = 0.8
nPatients | OTHER SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 9 | 356 | 98 | 36 |
subtype1 | 0 | 40 | 12 | 4 |
subtype2 | 8 | 255 | 64 | 28 |
subtype3 | 1 | 61 | 22 | 4 |
P value = 0.62 (Fisher's exact test), Q value = 0.75
nPatients | NO | YES |
---|---|---|
ALL | 14 | 485 |
subtype1 | 2 | 54 |
subtype2 | 11 | 344 |
subtype3 | 1 | 87 |
P value = 0.576 (Fisher's exact test), Q value = 0.73
nPatients | NO | YES |
---|---|---|
ALL | 421 | 17 |
subtype1 | 49 | 3 |
subtype2 | 296 | 12 |
subtype3 | 76 | 2 |
P value = 0.0564 (Fisher's exact test), Q value = 0.11
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 132 | 18 | 330 | 1 |
subtype1 | 15 | 4 | 34 | 1 |
subtype2 | 100 | 13 | 231 | 0 |
subtype3 | 17 | 1 | 65 | 0 |
P value = 0.0834 (Fisher's exact test), Q value = 0.16
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 381 | 52 | 4 | 30 |
subtype1 | 38 | 9 | 0 | 6 |
subtype2 | 279 | 36 | 3 | 15 |
subtype3 | 64 | 7 | 1 | 9 |
P value = 0.617 (Kruskal-Wallis (anova)), Q value = 0.75
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 383 | 3.7 (6.2) |
subtype1 | 42 | 2.8 (4.9) |
subtype2 | 272 | 3.8 (6.6) |
subtype3 | 69 | 3.7 (5.5) |
P value = 0.0289 (Fisher's exact test), Q value = 0.063
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 225 | 264 |
subtype1 | 21 | 35 |
subtype2 | 155 | 194 |
subtype3 | 49 | 35 |
P value = 0.00509 (Kruskal-Wallis (anova)), Q value = 0.014
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 401 | 3.0 (1.6) |
subtype1 | 50 | 3.6 (1.6) |
subtype2 | 281 | 2.9 (1.6) |
subtype3 | 70 | 2.9 (1.5) |
P value = 0.2 (Fisher's exact test), Q value = 0.31
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 52 | 27 | 325 |
subtype1 | 0 | 1 | 4 | 39 |
subtype2 | 1 | 40 | 17 | 232 |
subtype3 | 0 | 11 | 6 | 54 |
P value = 0.96 (Fisher's exact test), Q value = 0.98
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 38 | 358 |
subtype1 | 4 | 37 |
subtype2 | 27 | 259 |
subtype3 | 7 | 62 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 276 | 155 | 70 |
P value = 0.247 (logrank test), Q value = 0.37
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 499 | 14 | 0.1 - 169.3 (20.2) |
subtype1 | 276 | 7 | 0.1 - 169.3 (23.3) |
subtype2 | 153 | 3 | 0.2 - 132.4 (17.2) |
subtype3 | 70 | 4 | 0.1 - 147.4 (17.9) |
P value = 0.171 (Kruskal-Wallis (anova)), Q value = 0.29
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 501 | 47.2 (15.8) |
subtype1 | 276 | 47.0 (15.5) |
subtype2 | 155 | 48.6 (15.2) |
subtype3 | 70 | 45.0 (17.9) |
P value = 3e-05 (Fisher's exact test), Q value = 0.00013
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 283 | 53 | 109 | 2 | 46 | 6 |
subtype1 | 148 | 20 | 67 | 0 | 36 | 4 |
subtype2 | 89 | 31 | 27 | 1 | 4 | 2 |
subtype3 | 46 | 2 | 15 | 1 | 6 | 0 |
P value = 0.00188 (Fisher's exact test), Q value = 0.0055
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 142 | 167 | 167 | 23 |
subtype1 | 64 | 89 | 102 | 20 |
subtype2 | 53 | 58 | 43 | 1 |
subtype3 | 25 | 20 | 22 | 2 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 226 | 225 |
subtype1 | 96 | 159 |
subtype2 | 100 | 29 |
subtype3 | 30 | 37 |
P value = 0.639 (Fisher's exact test), Q value = 0.77
nPatients | 0 | 1 |
---|---|---|
ALL | 278 | 9 |
subtype1 | 164 | 6 |
subtype2 | 73 | 3 |
subtype3 | 41 | 0 |
P value = 0.949 (Fisher's exact test), Q value = 0.98
nPatients | FEMALE | MALE |
---|---|---|
ALL | 367 | 134 |
subtype1 | 203 | 73 |
subtype2 | 112 | 43 |
subtype3 | 52 | 18 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | OTHER SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 9 | 356 | 100 | 36 |
subtype1 | 5 | 225 | 17 | 29 |
subtype2 | 2 | 75 | 78 | 0 |
subtype3 | 2 | 56 | 5 | 7 |
P value = 0.117 (Fisher's exact test), Q value = 0.21
nPatients | NO | YES |
---|---|---|
ALL | 14 | 487 |
subtype1 | 11 | 265 |
subtype2 | 1 | 154 |
subtype3 | 2 | 68 |
P value = 0.648 (Fisher's exact test), Q value = 0.77
nPatients | NO | YES |
---|---|---|
ALL | 422 | 17 |
subtype1 | 238 | 8 |
subtype2 | 125 | 6 |
subtype3 | 59 | 3 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 132 | 18 | 332 | 1 |
subtype1 | 93 | 17 | 160 | 0 |
subtype2 | 24 | 0 | 122 | 0 |
subtype3 | 15 | 1 | 50 | 1 |
P value = 0.238 (Fisher's exact test), Q value = 0.36
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 383 | 52 | 4 | 30 |
subtype1 | 207 | 36 | 4 | 18 |
subtype2 | 123 | 9 | 0 | 8 |
subtype3 | 53 | 7 | 0 | 4 |
P value = 2.12e-08 (Kruskal-Wallis (anova)), Q value = 7.2e-07
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 384 | 3.7 (6.2) |
subtype1 | 227 | 4.5 (6.6) |
subtype2 | 100 | 1.7 (4.3) |
subtype3 | 57 | 4.0 (6.8) |
P value = 0.942 (Fisher's exact test), Q value = 0.98
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 226 | 265 |
subtype1 | 125 | 146 |
subtype2 | 71 | 81 |
subtype3 | 30 | 38 |
P value = 0.57 (Kruskal-Wallis (anova)), Q value = 0.73
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 402 | 3.0 (1.6) |
subtype1 | 224 | 3.0 (1.6) |
subtype2 | 123 | 3.1 (1.6) |
subtype3 | 55 | 2.8 (1.4) |
P value = 0.645 (Fisher's exact test), Q value = 0.77
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 52 | 27 | 326 |
subtype1 | 1 | 30 | 17 | 188 |
subtype2 | 0 | 14 | 9 | 85 |
subtype3 | 0 | 8 | 1 | 53 |
P value = 0.433 (Fisher's exact test), Q value = 0.57
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 38 | 359 |
subtype1 | 24 | 207 |
subtype2 | 7 | 99 |
subtype3 | 7 | 53 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 61 | 79 | 82 |
P value = 0.586 (logrank test), Q value = 0.73
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 222 | 13 | 0.1 - 158.8 (22.1) |
subtype1 | 61 | 4 | 1.2 - 158.8 (16.8) |
subtype2 | 79 | 4 | 0.2 - 147.4 (27.2) |
subtype3 | 82 | 5 | 0.1 - 147.8 (23.2) |
P value = 0.00134 (Kruskal-Wallis (anova)), Q value = 0.0042
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 222 | 48.1 (16.8) |
subtype1 | 61 | 51.6 (15.3) |
subtype2 | 79 | 50.7 (16.0) |
subtype3 | 82 | 42.9 (17.4) |
P value = 0.00167 (Fisher's exact test), Q value = 0.005
nPatients | STAGE I | STAGE II | STAGE III | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|
ALL | 117 | 33 | 46 | 20 | 4 |
subtype1 | 31 | 11 | 14 | 2 | 1 |
subtype2 | 31 | 13 | 21 | 14 | 0 |
subtype3 | 55 | 9 | 11 | 4 | 3 |
P value = 0.00356 (Fisher's exact test), Q value = 0.01
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 51 | 84 | 75 | 11 |
subtype1 | 22 | 23 | 15 | 0 |
subtype2 | 12 | 25 | 34 | 8 |
subtype3 | 17 | 36 | 26 | 3 |
P value = 0.0309 (Fisher's exact test), Q value = 0.066
nPatients | 0 | 1 |
---|---|---|
ALL | 98 | 95 |
subtype1 | 34 | 18 |
subtype2 | 29 | 41 |
subtype3 | 35 | 36 |
P value = 0.524 (Fisher's exact test), Q value = 0.68
nPatients | 0 | 1 |
---|---|---|
ALL | 118 | 5 |
subtype1 | 38 | 1 |
subtype2 | 43 | 1 |
subtype3 | 37 | 3 |
P value = 0.656 (Fisher's exact test), Q value = 0.77
nPatients | FEMALE | MALE |
---|---|---|
ALL | 154 | 68 |
subtype1 | 43 | 18 |
subtype2 | 57 | 22 |
subtype3 | 54 | 28 |
P value = 4e-05 (Fisher's exact test), Q value = 0.00017
nPatients | OTHER SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 2 | 158 | 52 | 10 |
subtype1 | 0 | 35 | 25 | 1 |
subtype2 | 1 | 55 | 14 | 9 |
subtype3 | 1 | 68 | 13 | 0 |
P value = 0.0104 (Fisher's exact test), Q value = 0.026
nPatients | NO | YES |
---|---|---|
ALL | 13 | 209 |
subtype1 | 0 | 61 |
subtype2 | 9 | 70 |
subtype3 | 4 | 78 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 184 | 11 |
subtype1 | 52 | 3 |
subtype2 | 67 | 4 |
subtype3 | 65 | 4 |
P value = 0.00073 (Fisher's exact test), Q value = 0.0026
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE |
---|---|---|---|
ALL | 55 | 10 | 149 |
subtype1 | 12 | 0 | 48 |
subtype2 | 28 | 8 | 41 |
subtype3 | 15 | 2 | 60 |
P value = 0.277 (Fisher's exact test), Q value = 0.4
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 168 | 23 | 2 | 14 |
subtype1 | 48 | 6 | 1 | 5 |
subtype2 | 58 | 13 | 0 | 4 |
subtype3 | 62 | 4 | 1 | 5 |
P value = 0.431 (Kruskal-Wallis (anova)), Q value = 0.57
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 168 | 3.5 (5.8) |
subtype1 | 43 | 3.8 (7.5) |
subtype2 | 63 | 3.2 (4.6) |
subtype3 | 62 | 3.5 (5.8) |
P value = 0.0143 (Fisher's exact test), Q value = 0.035
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 101 | 114 |
subtype1 | 35 | 23 |
subtype2 | 27 | 50 |
subtype3 | 39 | 41 |
P value = 0.711 (Kruskal-Wallis (anova)), Q value = 0.81
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 191 | 3.3 (1.6) |
subtype1 | 52 | 3.2 (1.6) |
subtype2 | 66 | 3.4 (1.5) |
subtype3 | 73 | 3.2 (1.5) |
P value = 0.0808 (Fisher's exact test), Q value = 0.15
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 16 | 13 | 147 |
subtype1 | 3 | 7 | 34 |
subtype2 | 4 | 4 | 59 |
subtype3 | 9 | 2 | 54 |
P value = 0.146 (Fisher's exact test), Q value = 0.25
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 16 | 168 |
subtype1 | 1 | 46 |
subtype2 | 8 | 59 |
subtype3 | 7 | 63 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
---|---|---|---|---|---|---|---|
Number of samples | 47 | 28 | 33 | 29 | 49 | 27 | 9 |
P value = 0.00158 (logrank test), Q value = 0.0048
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 222 | 13 | 0.1 - 158.8 (22.1) |
subtype1 | 47 | 4 | 1.2 - 158.8 (17.9) |
subtype2 | 28 | 1 | 1.4 - 66.8 (17.3) |
subtype3 | 33 | 0 | 0.2 - 139.0 (30.2) |
subtype4 | 29 | 2 | 0.3 - 155.5 (21.0) |
subtype5 | 49 | 1 | 0.1 - 147.8 (27.6) |
subtype6 | 27 | 1 | 3.4 - 81.3 (24.7) |
subtype7 | 9 | 4 | 14.0 - 147.4 (42.1) |
P value = 0.000999 (Kruskal-Wallis (anova)), Q value = 0.0033
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 222 | 48.1 (16.8) |
subtype1 | 47 | 52.5 (16.1) |
subtype2 | 28 | 49.6 (15.4) |
subtype3 | 33 | 47.6 (15.3) |
subtype4 | 29 | 45.3 (19.2) |
subtype5 | 49 | 40.1 (14.7) |
subtype6 | 27 | 52.2 (16.7) |
subtype7 | 9 | 61.8 (14.9) |
P value = 0.00104 (Fisher's exact test), Q value = 0.0034
nPatients | STAGE I | STAGE II | STAGE III | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|
ALL | 117 | 33 | 46 | 20 | 4 |
subtype1 | 26 | 11 | 6 | 1 | 1 |
subtype2 | 16 | 3 | 7 | 2 | 0 |
subtype3 | 13 | 4 | 11 | 5 | 0 |
subtype4 | 17 | 4 | 7 | 0 | 1 |
subtype5 | 35 | 3 | 6 | 4 | 1 |
subtype6 | 9 | 7 | 7 | 4 | 0 |
subtype7 | 1 | 1 | 2 | 4 | 1 |
P value = 0.00013 (Fisher's exact test), Q value = 0.00049
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 51 | 84 | 75 | 11 |
subtype1 | 16 | 22 | 9 | 0 |
subtype2 | 11 | 9 | 8 | 0 |
subtype3 | 3 | 11 | 17 | 2 |
subtype4 | 4 | 11 | 12 | 1 |
subtype5 | 11 | 21 | 16 | 1 |
subtype6 | 5 | 10 | 10 | 2 |
subtype7 | 1 | 0 | 3 | 5 |
P value = 0.00882 (Fisher's exact test), Q value = 0.023
nPatients | 0 | 1 |
---|---|---|
ALL | 98 | 95 |
subtype1 | 28 | 11 |
subtype2 | 13 | 13 |
subtype3 | 10 | 22 |
subtype4 | 17 | 9 |
subtype5 | 16 | 26 |
subtype6 | 11 | 10 |
subtype7 | 3 | 4 |
P value = 0.757 (Fisher's exact test), Q value = 0.85
nPatients | 0 | 1 |
---|---|---|
ALL | 118 | 5 |
subtype1 | 21 | 1 |
subtype2 | 19 | 0 |
subtype3 | 21 | 1 |
subtype4 | 13 | 1 |
subtype5 | 26 | 1 |
subtype6 | 11 | 0 |
subtype7 | 7 | 1 |
P value = 0.942 (Fisher's exact test), Q value = 0.98
nPatients | FEMALE | MALE |
---|---|---|
ALL | 154 | 68 |
subtype1 | 31 | 16 |
subtype2 | 18 | 10 |
subtype3 | 25 | 8 |
subtype4 | 21 | 8 |
subtype5 | 33 | 16 |
subtype6 | 20 | 7 |
subtype7 | 6 | 3 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | OTHER SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 2 | 158 | 52 | 10 |
subtype1 | 0 | 22 | 25 | 0 |
subtype2 | 0 | 22 | 5 | 1 |
subtype3 | 0 | 25 | 0 | 8 |
subtype4 | 0 | 22 | 7 | 0 |
subtype5 | 1 | 46 | 2 | 0 |
subtype6 | 1 | 12 | 13 | 1 |
subtype7 | 0 | 9 | 0 | 0 |
P value = 0.19 (Fisher's exact test), Q value = 0.31
nPatients | NO | YES |
---|---|---|
ALL | 13 | 209 |
subtype1 | 0 | 47 |
subtype2 | 2 | 26 |
subtype3 | 4 | 29 |
subtype4 | 1 | 28 |
subtype5 | 3 | 46 |
subtype6 | 3 | 24 |
subtype7 | 0 | 9 |
P value = 0.236 (Fisher's exact test), Q value = 0.36
nPatients | NO | YES |
---|---|---|
ALL | 184 | 11 |
subtype1 | 39 | 3 |
subtype2 | 26 | 0 |
subtype3 | 29 | 0 |
subtype4 | 22 | 2 |
subtype5 | 39 | 2 |
subtype6 | 23 | 3 |
subtype7 | 6 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE |
---|---|---|---|
ALL | 55 | 10 | 149 |
subtype1 | 4 | 0 | 42 |
subtype2 | 9 | 0 | 19 |
subtype3 | 15 | 3 | 14 |
subtype4 | 6 | 1 | 18 |
subtype5 | 12 | 0 | 36 |
subtype6 | 6 | 2 | 19 |
subtype7 | 3 | 4 | 1 |
P value = 0.0938 (Fisher's exact test), Q value = 0.17
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 168 | 23 | 2 | 14 |
subtype1 | 37 | 5 | 0 | 3 |
subtype2 | 22 | 3 | 0 | 2 |
subtype3 | 24 | 7 | 0 | 0 |
subtype4 | 19 | 2 | 2 | 1 |
subtype5 | 39 | 3 | 0 | 3 |
subtype6 | 23 | 1 | 0 | 3 |
subtype7 | 4 | 2 | 0 | 2 |
P value = 0.375 (Kruskal-Wallis (anova)), Q value = 0.52
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 168 | 3.5 (5.8) |
subtype1 | 31 | 2.9 (6.6) |
subtype2 | 25 | 3.9 (7.0) |
subtype3 | 26 | 3.3 (3.9) |
subtype4 | 22 | 2.8 (4.2) |
subtype5 | 38 | 4.0 (6.6) |
subtype6 | 19 | 3.7 (5.9) |
subtype7 | 7 | 4.0 (5.3) |
P value = 0.117 (Fisher's exact test), Q value = 0.21
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 101 | 114 |
subtype1 | 28 | 16 |
subtype2 | 12 | 16 |
subtype3 | 12 | 20 |
subtype4 | 12 | 17 |
subtype5 | 25 | 22 |
subtype6 | 10 | 16 |
subtype7 | 2 | 7 |
P value = 0.0203 (Kruskal-Wallis (anova)), Q value = 0.047
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 191 | 3.3 (1.6) |
subtype1 | 38 | 3.4 (1.5) |
subtype2 | 27 | 2.6 (1.6) |
subtype3 | 29 | 3.3 (1.3) |
subtype4 | 24 | 3.6 (1.5) |
subtype5 | 45 | 3.1 (1.5) |
subtype6 | 22 | 3.3 (1.6) |
subtype7 | 6 | 5.2 (1.8) |
P value = 0.277 (Fisher's exact test), Q value = 0.4
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 16 | 13 | 147 |
subtype1 | 1 | 6 | 24 |
subtype2 | 2 | 1 | 19 |
subtype3 | 3 | 0 | 28 |
subtype4 | 2 | 1 | 20 |
subtype5 | 7 | 2 | 32 |
subtype6 | 1 | 2 | 16 |
subtype7 | 0 | 1 | 8 |
P value = 0.937 (Fisher's exact test), Q value = 0.98
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 16 | 168 |
subtype1 | 2 | 32 |
subtype2 | 1 | 23 |
subtype3 | 3 | 28 |
subtype4 | 2 | 22 |
subtype5 | 5 | 38 |
subtype6 | 2 | 17 |
subtype7 | 1 | 8 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 167 | 156 | 59 | 117 |
P value = 0.526 (logrank test), Q value = 0.68
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 497 | 14 | 0.1 - 169.3 (20.2) |
subtype1 | 167 | 7 | 0.1 - 155.5 (22.3) |
subtype2 | 155 | 3 | 0.2 - 132.4 (17.2) |
subtype3 | 59 | 2 | 0.1 - 157.2 (16.3) |
subtype4 | 116 | 2 | 0.2 - 169.3 (27.3) |
P value = 0.157 (Kruskal-Wallis (anova)), Q value = 0.27
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 499 | 47.2 (15.8) |
subtype1 | 167 | 48.3 (15.9) |
subtype2 | 156 | 48.6 (15.3) |
subtype3 | 59 | 45.3 (18.9) |
subtype4 | 117 | 44.8 (14.5) |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 282 | 53 | 108 | 2 | 46 | 6 |
subtype1 | 84 | 7 | 45 | 1 | 28 | 2 |
subtype2 | 90 | 30 | 27 | 1 | 5 | 2 |
subtype3 | 41 | 1 | 13 | 0 | 4 | 0 |
subtype4 | 67 | 15 | 23 | 0 | 9 | 2 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 141 | 166 | 167 | 23 |
subtype1 | 27 | 47 | 77 | 15 |
subtype2 | 53 | 57 | 44 | 2 |
subtype3 | 27 | 14 | 15 | 2 |
subtype4 | 34 | 48 | 31 | 4 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 225 | 224 |
subtype1 | 51 | 101 |
subtype2 | 101 | 29 |
subtype3 | 23 | 36 |
subtype4 | 50 | 58 |
P value = 0.755 (Fisher's exact test), Q value = 0.85
nPatients | 0 | 1 |
---|---|---|
ALL | 277 | 9 |
subtype1 | 94 | 3 |
subtype2 | 70 | 3 |
subtype3 | 41 | 0 |
subtype4 | 72 | 3 |
P value = 0.878 (Fisher's exact test), Q value = 0.96
nPatients | FEMALE | MALE |
---|---|---|
ALL | 365 | 134 |
subtype1 | 120 | 47 |
subtype2 | 113 | 43 |
subtype3 | 43 | 16 |
subtype4 | 89 | 28 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | OTHER SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 9 | 355 | 100 | 35 |
subtype1 | 4 | 134 | 3 | 26 |
subtype2 | 2 | 71 | 82 | 1 |
subtype3 | 1 | 50 | 3 | 5 |
subtype4 | 2 | 100 | 12 | 3 |
P value = 0.00568 (Fisher's exact test), Q value = 0.015
nPatients | NO | YES |
---|---|---|
ALL | 14 | 485 |
subtype1 | 11 | 156 |
subtype2 | 1 | 155 |
subtype3 | 0 | 59 |
subtype4 | 2 | 115 |
P value = 0.984 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 420 | 17 |
subtype1 | 143 | 5 |
subtype2 | 129 | 6 |
subtype3 | 49 | 2 |
subtype4 | 99 | 4 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 132 | 18 | 330 | 1 |
subtype1 | 67 | 14 | 81 | 1 |
subtype2 | 23 | 1 | 123 | 0 |
subtype3 | 13 | 2 | 41 | 0 |
subtype4 | 29 | 1 | 85 | 0 |
P value = 0.156 (Fisher's exact test), Q value = 0.27
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 381 | 52 | 4 | 30 |
subtype1 | 126 | 26 | 2 | 9 |
subtype2 | 124 | 9 | 0 | 8 |
subtype3 | 41 | 7 | 0 | 5 |
subtype4 | 90 | 10 | 2 | 8 |
P value = 8.57e-09 (Kruskal-Wallis (anova)), Q value = 3.8e-07
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 382 | 3.7 (6.2) |
subtype1 | 136 | 4.4 (6.6) |
subtype2 | 104 | 1.7 (4.4) |
subtype3 | 52 | 5.2 (7.4) |
subtype4 | 90 | 4.0 (6.3) |
P value = 0.236 (Fisher's exact test), Q value = 0.36
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 225 | 264 |
subtype1 | 66 | 99 |
subtype2 | 74 | 79 |
subtype3 | 26 | 31 |
subtype4 | 59 | 55 |
P value = 0.0384 (Kruskal-Wallis (anova)), Q value = 0.079
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 401 | 3.0 (1.6) |
subtype1 | 142 | 3.2 (1.6) |
subtype2 | 123 | 3.1 (1.6) |
subtype3 | 43 | 2.5 (1.7) |
subtype4 | 93 | 2.8 (1.5) |
P value = 0.701 (Fisher's exact test), Q value = 0.8
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 51 | 27 | 326 |
subtype1 | 1 | 17 | 11 | 118 |
subtype2 | 0 | 11 | 9 | 88 |
subtype3 | 0 | 7 | 1 | 45 |
subtype4 | 0 | 16 | 6 | 75 |
P value = 0.00686 (Fisher's exact test), Q value = 0.018
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 38 | 357 |
subtype1 | 23 | 120 |
subtype2 | 9 | 98 |
subtype3 | 3 | 49 |
subtype4 | 3 | 90 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 105 | 135 | 86 | 96 | 77 |
P value = 0.677 (logrank test), Q value = 0.79
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 497 | 14 | 0.1 - 169.3 (20.2) |
subtype1 | 105 | 5 | 1.4 - 157.2 (22.9) |
subtype2 | 134 | 4 | 0.2 - 132.4 (16.6) |
subtype3 | 86 | 1 | 0.1 - 130.7 (17.8) |
subtype4 | 95 | 2 | 0.2 - 169.3 (27.9) |
subtype5 | 77 | 2 | 0.1 - 147.8 (23.5) |
P value = 0.00242 (Kruskal-Wallis (anova)), Q value = 0.007
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 499 | 47.2 (15.8) |
subtype1 | 105 | 51.0 (16.1) |
subtype2 | 135 | 49.6 (16.0) |
subtype3 | 86 | 44.5 (15.1) |
subtype4 | 96 | 45.3 (14.6) |
subtype5 | 77 | 43.4 (15.9) |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 282 | 53 | 108 | 2 | 46 | 6 |
subtype1 | 46 | 2 | 39 | 1 | 16 | 1 |
subtype2 | 76 | 30 | 21 | 1 | 4 | 2 |
subtype3 | 57 | 3 | 18 | 0 | 8 | 0 |
subtype4 | 54 | 12 | 19 | 0 | 8 | 2 |
subtype5 | 49 | 6 | 11 | 0 | 10 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 141 | 166 | 167 | 23 |
subtype1 | 17 | 22 | 56 | 10 |
subtype2 | 43 | 55 | 35 | 2 |
subtype3 | 38 | 22 | 23 | 1 |
subtype4 | 26 | 41 | 25 | 4 |
subtype5 | 17 | 26 | 28 | 6 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 225 | 224 |
subtype1 | 29 | 68 |
subtype2 | 90 | 19 |
subtype3 | 38 | 45 |
subtype4 | 43 | 45 |
subtype5 | 25 | 47 |
P value = 0.393 (Fisher's exact test), Q value = 0.54
nPatients | 0 | 1 |
---|---|---|
ALL | 277 | 9 |
subtype1 | 56 | 1 |
subtype2 | 56 | 3 |
subtype3 | 60 | 0 |
subtype4 | 58 | 3 |
subtype5 | 47 | 2 |
P value = 0.169 (Fisher's exact test), Q value = 0.28
nPatients | FEMALE | MALE |
---|---|---|
ALL | 365 | 134 |
subtype1 | 84 | 21 |
subtype2 | 96 | 39 |
subtype3 | 61 | 25 |
subtype4 | 74 | 22 |
subtype5 | 50 | 27 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | OTHER SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 9 | 355 | 100 | 35 |
subtype1 | 1 | 79 | 2 | 23 |
subtype2 | 2 | 57 | 76 | 0 |
subtype3 | 2 | 68 | 10 | 6 |
subtype4 | 0 | 83 | 11 | 2 |
subtype5 | 4 | 68 | 1 | 4 |
P value = 0.0733 (Fisher's exact test), Q value = 0.14
nPatients | NO | YES |
---|---|---|
ALL | 14 | 485 |
subtype1 | 5 | 100 |
subtype2 | 1 | 134 |
subtype3 | 1 | 85 |
subtype4 | 2 | 94 |
subtype5 | 5 | 72 |
P value = 0.254 (Fisher's exact test), Q value = 0.37
nPatients | NO | YES |
---|---|---|
ALL | 420 | 17 |
subtype1 | 95 | 3 |
subtype2 | 111 | 5 |
subtype3 | 66 | 6 |
subtype4 | 85 | 1 |
subtype5 | 63 | 2 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 132 | 18 | 330 | 1 |
subtype1 | 53 | 10 | 38 | 1 |
subtype2 | 15 | 1 | 110 | 0 |
subtype3 | 20 | 1 | 62 | 0 |
subtype4 | 22 | 1 | 71 | 0 |
subtype5 | 22 | 5 | 49 | 0 |
P value = 0.0209 (Fisher's exact test), Q value = 0.048
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 381 | 52 | 4 | 30 |
subtype1 | 70 | 23 | 2 | 6 |
subtype2 | 103 | 10 | 0 | 8 |
subtype3 | 70 | 4 | 0 | 6 |
subtype4 | 76 | 8 | 2 | 6 |
subtype5 | 62 | 7 | 0 | 4 |
P value = 8.83e-09 (Kruskal-Wallis (anova)), Q value = 3.8e-07
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 382 | 3.7 (6.2) |
subtype1 | 92 | 4.7 (6.6) |
subtype2 | 86 | 1.4 (3.5) |
subtype3 | 71 | 4.8 (8.5) |
subtype4 | 72 | 3.8 (6.3) |
subtype5 | 61 | 3.8 (4.6) |
P value = 0.225 (Fisher's exact test), Q value = 0.35
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 225 | 264 |
subtype1 | 39 | 66 |
subtype2 | 64 | 68 |
subtype3 | 43 | 41 |
subtype4 | 47 | 46 |
subtype5 | 32 | 43 |
P value = 0.00154 (Kruskal-Wallis (anova)), Q value = 0.0047
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 401 | 3.0 (1.6) |
subtype1 | 93 | 3.1 (1.5) |
subtype2 | 111 | 3.2 (1.5) |
subtype3 | 62 | 2.3 (1.5) |
subtype4 | 76 | 2.9 (1.5) |
subtype5 | 59 | 3.2 (1.8) |
P value = 0.00114 (Fisher's exact test), Q value = 0.0037
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 51 | 27 | 326 |
subtype1 | 1 | 4 | 11 | 77 |
subtype2 | 0 | 7 | 8 | 74 |
subtype3 | 0 | 17 | 1 | 60 |
subtype4 | 0 | 12 | 6 | 59 |
subtype5 | 0 | 11 | 1 | 56 |
P value = 0.0312 (Fisher's exact test), Q value = 0.066
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 38 | 357 |
subtype1 | 15 | 77 |
subtype2 | 9 | 81 |
subtype3 | 3 | 71 |
subtype4 | 3 | 71 |
subtype5 | 8 | 57 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 182 | 152 | 166 |
P value = 0.0239 (logrank test), Q value = 0.053
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 498 | 14 | 0.1 - 169.3 (20.3) |
subtype1 | 182 | 10 | 0.1 - 158.8 (20.1) |
subtype2 | 151 | 3 | 0.2 - 132.4 (17.1) |
subtype3 | 165 | 1 | 0.1 - 169.3 (24.3) |
P value = 0.0512 (Kruskal-Wallis (anova)), Q value = 0.1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 500 | 47.3 (15.8) |
subtype1 | 182 | 49.4 (16.0) |
subtype2 | 152 | 47.0 (16.2) |
subtype3 | 166 | 45.1 (14.9) |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 282 | 53 | 109 | 2 | 46 | 6 |
subtype1 | 90 | 6 | 56 | 1 | 26 | 2 |
subtype2 | 93 | 29 | 21 | 1 | 5 | 2 |
subtype3 | 99 | 18 | 32 | 0 | 15 | 2 |
P value = 7e-05 (Fisher's exact test), Q value = 0.00028
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 142 | 167 | 166 | 23 |
subtype1 | 56 | 39 | 70 | 15 |
subtype2 | 43 | 68 | 39 | 2 |
subtype3 | 43 | 60 | 57 | 6 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 226 | 224 |
subtype1 | 65 | 108 |
subtype2 | 96 | 28 |
subtype3 | 65 | 88 |
P value = 0.461 (Fisher's exact test), Q value = 0.6
nPatients | 0 | 1 |
---|---|---|
ALL | 277 | 9 |
subtype1 | 122 | 2 |
subtype2 | 65 | 3 |
subtype3 | 90 | 4 |
P value = 0.883 (Fisher's exact test), Q value = 0.96
nPatients | FEMALE | MALE |
---|---|---|
ALL | 366 | 134 |
subtype1 | 135 | 47 |
subtype2 | 109 | 43 |
subtype3 | 122 | 44 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | OTHER SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 9 | 355 | 100 | 36 |
subtype1 | 4 | 144 | 8 | 26 |
subtype2 | 2 | 67 | 83 | 0 |
subtype3 | 3 | 144 | 9 | 10 |
P value = 0.193 (Fisher's exact test), Q value = 0.31
nPatients | NO | YES |
---|---|---|
ALL | 14 | 486 |
subtype1 | 3 | 179 |
subtype2 | 3 | 149 |
subtype3 | 8 | 158 |
P value = 0.951 (Fisher's exact test), Q value = 0.98
nPatients | NO | YES |
---|---|---|
ALL | 421 | 17 |
subtype1 | 154 | 7 |
subtype2 | 127 | 5 |
subtype3 | 140 | 5 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 131 | 18 | 332 | 1 |
subtype1 | 64 | 14 | 97 | 1 |
subtype2 | 16 | 0 | 128 | 0 |
subtype3 | 51 | 4 | 107 | 0 |
P value = 0.19 (Fisher's exact test), Q value = 0.31
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 382 | 52 | 4 | 30 |
subtype1 | 132 | 26 | 3 | 12 |
subtype2 | 119 | 10 | 0 | 10 |
subtype3 | 131 | 16 | 1 | 8 |
P value = 6.95e-09 (Kruskal-Wallis (anova)), Q value = 3.8e-07
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 383 | 3.7 (6.2) |
subtype1 | 149 | 5.1 (7.3) |
subtype2 | 100 | 1.6 (3.5) |
subtype3 | 134 | 3.6 (6.1) |
P value = 0.885 (Fisher's exact test), Q value = 0.96
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 225 | 265 |
subtype1 | 82 | 99 |
subtype2 | 66 | 81 |
subtype3 | 77 | 85 |
P value = 0.0233 (Kruskal-Wallis (anova)), Q value = 0.053
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 401 | 3.0 (1.6) |
subtype1 | 142 | 2.8 (1.7) |
subtype2 | 126 | 3.2 (1.5) |
subtype3 | 133 | 2.9 (1.5) |
P value = 0.357 (Fisher's exact test), Q value = 0.51
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 52 | 27 | 326 |
subtype1 | 0 | 25 | 8 | 132 |
subtype2 | 0 | 9 | 10 | 86 |
subtype3 | 1 | 18 | 9 | 108 |
P value = 0.698 (Fisher's exact test), Q value = 0.8
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 38 | 358 |
subtype1 | 13 | 144 |
subtype2 | 10 | 95 |
subtype3 | 15 | 119 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 179 | 130 | 191 |
P value = 0.0135 (logrank test), Q value = 0.033
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 498 | 14 | 0.1 - 169.3 (20.3) |
subtype1 | 179 | 10 | 0.1 - 158.8 (19.2) |
subtype2 | 129 | 3 | 0.3 - 132.4 (16.6) |
subtype3 | 190 | 1 | 0.1 - 169.3 (25.0) |
P value = 0.000963 (Kruskal-Wallis (anova)), Q value = 0.0033
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 500 | 47.3 (15.8) |
subtype1 | 179 | 49.7 (16.2) |
subtype2 | 130 | 49.1 (15.5) |
subtype3 | 191 | 43.7 (15.0) |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 282 | 53 | 109 | 2 | 46 | 6 |
subtype1 | 88 | 5 | 57 | 1 | 25 | 2 |
subtype2 | 74 | 28 | 20 | 1 | 4 | 2 |
subtype3 | 120 | 20 | 32 | 0 | 17 | 2 |
P value = 5e-05 (Fisher's exact test), Q value = 2e-04
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 142 | 167 | 166 | 23 |
subtype1 | 55 | 37 | 70 | 15 |
subtype2 | 41 | 53 | 35 | 1 |
subtype3 | 46 | 77 | 61 | 7 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 226 | 224 |
subtype1 | 66 | 103 |
subtype2 | 86 | 19 |
subtype3 | 74 | 102 |
P value = 0.335 (Fisher's exact test), Q value = 0.48
nPatients | 0 | 1 |
---|---|---|
ALL | 277 | 9 |
subtype1 | 124 | 2 |
subtype2 | 55 | 3 |
subtype3 | 98 | 4 |
P value = 0.646 (Fisher's exact test), Q value = 0.77
nPatients | FEMALE | MALE |
---|---|---|
ALL | 366 | 134 |
subtype1 | 135 | 44 |
subtype2 | 92 | 38 |
subtype3 | 139 | 52 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | OTHER SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 9 | 355 | 100 | 36 |
subtype1 | 3 | 141 | 9 | 26 |
subtype2 | 2 | 51 | 77 | 0 |
subtype3 | 4 | 163 | 14 | 10 |
P value = 0.00952 (Fisher's exact test), Q value = 0.025
nPatients | NO | YES |
---|---|---|
ALL | 14 | 486 |
subtype1 | 2 | 177 |
subtype2 | 1 | 129 |
subtype3 | 11 | 180 |
P value = 0.906 (Fisher's exact test), Q value = 0.96
nPatients | NO | YES |
---|---|---|
ALL | 421 | 17 |
subtype1 | 153 | 6 |
subtype2 | 107 | 5 |
subtype3 | 161 | 6 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 131 | 18 | 332 | 1 |
subtype1 | 67 | 14 | 91 | 1 |
subtype2 | 15 | 0 | 107 | 0 |
subtype3 | 49 | 4 | 134 | 0 |
P value = 0.203 (Fisher's exact test), Q value = 0.32
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 382 | 52 | 4 | 30 |
subtype1 | 129 | 26 | 3 | 13 |
subtype2 | 101 | 9 | 0 | 7 |
subtype3 | 152 | 17 | 1 | 10 |
P value = 2.21e-09 (Kruskal-Wallis (anova)), Q value = 3.8e-07
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 383 | 3.7 (6.2) |
subtype1 | 143 | 4.7 (6.5) |
subtype2 | 85 | 1.7 (4.6) |
subtype3 | 155 | 3.8 (6.5) |
P value = 0.589 (Fisher's exact test), Q value = 0.73
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 225 | 265 |
subtype1 | 76 | 101 |
subtype2 | 62 | 66 |
subtype3 | 87 | 98 |
P value = 0.0352 (Kruskal-Wallis (anova)), Q value = 0.073
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 401 | 3.0 (1.6) |
subtype1 | 139 | 2.8 (1.6) |
subtype2 | 109 | 3.2 (1.6) |
subtype3 | 153 | 3.0 (1.5) |
P value = 0.192 (Fisher's exact test), Q value = 0.31
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 52 | 27 | 326 |
subtype1 | 0 | 26 | 7 | 130 |
subtype2 | 0 | 6 | 8 | 71 |
subtype3 | 1 | 20 | 12 | 125 |
P value = 0.777 (Fisher's exact test), Q value = 0.86
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 38 | 358 |
subtype1 | 13 | 142 |
subtype2 | 8 | 76 |
subtype3 | 17 | 140 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 161 | 164 | 145 |
P value = 0.0198 (logrank test), Q value = 0.047
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 468 | 14 | 0.1 - 169.3 (20.2) |
subtype1 | 161 | 10 | 0.1 - 157.2 (19.2) |
subtype2 | 164 | 2 | 0.1 - 169.3 (23.1) |
subtype3 | 143 | 2 | 0.1 - 132.1 (19.1) |
P value = 0.0201 (Kruskal-Wallis (anova)), Q value = 0.047
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 470 | 47.3 (15.8) |
subtype1 | 161 | 49.7 (16.5) |
subtype2 | 164 | 44.8 (15.8) |
subtype3 | 145 | 47.4 (14.6) |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 266 | 51 | 102 | 2 | 41 | 6 |
subtype1 | 78 | 6 | 52 | 1 | 22 | 2 |
subtype2 | 105 | 28 | 20 | 0 | 8 | 2 |
subtype3 | 83 | 17 | 30 | 1 | 11 | 2 |
P value = 8e-05 (Fisher's exact test), Q value = 0.00031
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 135 | 157 | 154 | 22 |
subtype1 | 42 | 35 | 68 | 15 |
subtype2 | 47 | 67 | 45 | 5 |
subtype3 | 46 | 55 | 41 | 2 |
P value = 0.00083 (Fisher's exact test), Q value = 0.0029
nPatients | 0 | 1 |
---|---|---|
ALL | 212 | 211 |
subtype1 | 59 | 95 |
subtype2 | 87 | 58 |
subtype3 | 66 | 58 |
P value = 0.436 (Fisher's exact test), Q value = 0.57
nPatients | 0 | 1 |
---|---|---|
ALL | 261 | 9 |
subtype1 | 108 | 2 |
subtype2 | 71 | 4 |
subtype3 | 82 | 3 |
P value = 0.956 (Fisher's exact test), Q value = 0.98
nPatients | FEMALE | MALE |
---|---|---|
ALL | 344 | 126 |
subtype1 | 119 | 42 |
subtype2 | 119 | 45 |
subtype3 | 106 | 39 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | OTHER SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 9 | 339 | 90 | 32 |
subtype1 | 3 | 126 | 7 | 25 |
subtype2 | 2 | 113 | 46 | 3 |
subtype3 | 4 | 100 | 37 | 4 |
P value = 0.00019 (Fisher's exact test), Q value = 0.00069
nPatients | NO | YES |
---|---|---|
ALL | 14 | 456 |
subtype1 | 2 | 159 |
subtype2 | 12 | 152 |
subtype3 | 0 | 145 |
P value = 0.431 (Fisher's exact test), Q value = 0.57
nPatients | NO | YES |
---|---|---|
ALL | 396 | 16 |
subtype1 | 135 | 5 |
subtype2 | 136 | 8 |
subtype3 | 125 | 3 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 124 | 17 | 311 | 1 |
subtype1 | 60 | 14 | 79 | 1 |
subtype2 | 30 | 2 | 127 | 0 |
subtype3 | 34 | 1 | 105 | 0 |
P value = 0.032 (Fisher's exact test), Q value = 0.067
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 358 | 49 | 4 | 29 |
subtype1 | 112 | 25 | 3 | 9 |
subtype2 | 137 | 9 | 1 | 11 |
subtype3 | 109 | 15 | 0 | 9 |
P value = 0.00995 (Kruskal-Wallis (anova)), Q value = 0.025
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 358 | 3.7 (6.2) |
subtype1 | 135 | 4.6 (6.9) |
subtype2 | 116 | 3.0 (4.7) |
subtype3 | 107 | 3.4 (6.5) |
P value = 0.905 (Fisher's exact test), Q value = 0.96
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 214 | 248 |
subtype1 | 75 | 86 |
subtype2 | 71 | 87 |
subtype3 | 68 | 75 |
P value = 0.128 (Kruskal-Wallis (anova)), Q value = 0.22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 377 | 3.0 (1.6) |
subtype1 | 126 | 2.9 (1.7) |
subtype2 | 132 | 3.1 (1.5) |
subtype3 | 119 | 2.9 (1.6) |
P value = 0.0406 (Fisher's exact test), Q value = 0.082
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 49 | 26 | 308 |
subtype1 | 0 | 18 | 6 | 122 |
subtype2 | 0 | 12 | 7 | 107 |
subtype3 | 1 | 19 | 13 | 79 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 35 | 340 |
subtype1 | 14 | 130 |
subtype2 | 12 | 117 |
subtype3 | 9 | 93 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 165 | 127 | 178 |
P value = 0.0037 (logrank test), Q value = 0.01
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 468 | 14 | 0.1 - 169.3 (20.2) |
subtype1 | 165 | 10 | 0.1 - 157.2 (19.0) |
subtype2 | 126 | 3 | 0.3 - 132.4 (16.4) |
subtype3 | 177 | 1 | 0.1 - 169.3 (27.1) |
P value = 0.00018 (Kruskal-Wallis (anova)), Q value = 0.00066
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 470 | 47.3 (15.8) |
subtype1 | 165 | 50.1 (16.3) |
subtype2 | 127 | 49.1 (15.7) |
subtype3 | 178 | 43.3 (14.5) |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 266 | 51 | 102 | 2 | 41 | 6 |
subtype1 | 77 | 4 | 58 | 1 | 23 | 2 |
subtype2 | 70 | 27 | 23 | 1 | 3 | 2 |
subtype3 | 119 | 20 | 21 | 0 | 15 | 2 |
P value = 3e-05 (Fisher's exact test), Q value = 0.00013
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 135 | 157 | 154 | 22 |
subtype1 | 47 | 34 | 67 | 15 |
subtype2 | 38 | 54 | 34 | 1 |
subtype3 | 50 | 69 | 53 | 6 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 212 | 211 |
subtype1 | 59 | 98 |
subtype2 | 80 | 22 |
subtype3 | 73 | 91 |
P value = 0.369 (Fisher's exact test), Q value = 0.52
nPatients | 0 | 1 |
---|---|---|
ALL | 261 | 9 |
subtype1 | 114 | 2 |
subtype2 | 51 | 3 |
subtype3 | 96 | 4 |
P value = 0.184 (Fisher's exact test), Q value = 0.3
nPatients | FEMALE | MALE |
---|---|---|
ALL | 344 | 126 |
subtype1 | 125 | 40 |
subtype2 | 85 | 42 |
subtype3 | 134 | 44 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | OTHER SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 9 | 339 | 90 | 32 |
subtype1 | 3 | 130 | 7 | 25 |
subtype2 | 2 | 56 | 69 | 0 |
subtype3 | 4 | 153 | 14 | 7 |
P value = 0.105 (Fisher's exact test), Q value = 0.19
nPatients | NO | YES |
---|---|---|
ALL | 14 | 456 |
subtype1 | 2 | 163 |
subtype2 | 3 | 124 |
subtype3 | 9 | 169 |
P value = 0.854 (Fisher's exact test), Q value = 0.94
nPatients | NO | YES |
---|---|---|
ALL | 396 | 16 |
subtype1 | 139 | 6 |
subtype2 | 106 | 5 |
subtype3 | 151 | 5 |
P value = 1e-05 (Fisher's exact test), Q value = 4.6e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 124 | 17 | 311 | 1 |
subtype1 | 63 | 14 | 81 | 1 |
subtype2 | 17 | 0 | 103 | 0 |
subtype3 | 44 | 3 | 127 | 0 |
P value = 0.0516 (Fisher's exact test), Q value = 0.1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 358 | 49 | 4 | 29 |
subtype1 | 115 | 27 | 2 | 11 |
subtype2 | 97 | 9 | 0 | 9 |
subtype3 | 146 | 13 | 2 | 9 |
P value = 7.02e-08 (Kruskal-Wallis (anova)), Q value = 1.7e-06
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 358 | 3.7 (6.2) |
subtype1 | 135 | 4.7 (6.2) |
subtype2 | 80 | 1.4 (3.3) |
subtype3 | 143 | 4.1 (7.1) |
P value = 0.583 (Fisher's exact test), Q value = 0.73
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 214 | 248 |
subtype1 | 72 | 92 |
subtype2 | 62 | 62 |
subtype3 | 80 | 94 |
P value = 0.0271 (Kruskal-Wallis (anova)), Q value = 0.06
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 377 | 3.0 (1.6) |
subtype1 | 126 | 2.7 (1.6) |
subtype2 | 107 | 3.2 (1.6) |
subtype3 | 144 | 3.0 (1.6) |
P value = 0.0874 (Fisher's exact test), Q value = 0.16
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 49 | 26 | 308 |
subtype1 | 0 | 25 | 5 | 122 |
subtype2 | 0 | 7 | 9 | 69 |
subtype3 | 1 | 17 | 12 | 117 |
P value = 0.247 (Fisher's exact test), Q value = 0.37
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 35 | 340 |
subtype1 | 10 | 136 |
subtype2 | 7 | 79 |
subtype3 | 18 | 125 |
-
Cluster data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_mergedClustering/THCA-TP/15125146/THCA-TP.mergedcluster.txt
-
Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/THCA-TP/15092795/THCA-TP.merged_data.txt
-
Number of patients = 501
-
Number of clustering approaches = 10
-
Number of selected clinical features = 17
-
Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.