Correlation between gene mutation status and selected clinical features
Uterine Corpus Endometrioid Carcinoma (Primary solid tumor)
21 August 2015  |  analyses__2015_08_21
Maintainer Information
Citation Information
doi:10.7908/C1W958H5
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2015): Correlation between gene mutation status and selected clinical features. Broad Institute of MIT and Harvard. doi:10.7908/C1W958H5
Overview
Introduction

This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.

Summary

Testing the association between mutation status of 197 genes and 7 clinical features across 248 patients, 15 significant findings detected with Q value < 0.25.

  • PTEN mutation correlated to 'HISTOLOGICAL_TYPE' and 'RACE'.

  • PIK3R1 mutation correlated to 'HISTOLOGICAL_TYPE'.

  • TP53 mutation correlated to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.

  • CTCF mutation correlated to 'HISTOLOGICAL_TYPE'.

  • ARID1A mutation correlated to 'Time to Death' and 'HISTOLOGICAL_TYPE'.

  • KRAS mutation correlated to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.

  • CTNNB1 mutation correlated to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.

  • PPP2R1A mutation correlated to 'HISTOLOGICAL_TYPE'.

  • ARID5B mutation correlated to 'RACE'.

  • WDR65 mutation correlated to 'YEARS_TO_BIRTH'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between mutation status of 197 genes and 7 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 15 significant findings detected.

Clinical
Features 		Time
to
Death 		YEARS
TO
BIRTH 		RADIATION
THERAPY 		HISTOLOGICAL
TYPE 		RESIDUAL
TUMOR 		RACE ETHNICITY
nMutated (%) nWild-Type logrank test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test
PTEN 161 (65%) 87 0.00681
(0.398) 		0.00753
(0.398) 		0.0728
(0.76) 		1e-05
(0.00276) 		0.0482
(0.71) 		0.00066
(0.0827) 		1
(1.00)
TP53 69 (28%) 179 0.00729
(0.398) 		5.85e-06
(0.00276) 		0.461
(0.831) 		1e-05
(0.00276) 		0.0482
(0.71) 		0.00937
(0.404) 		0.615
(0.91)
ARID1A 83 (33%) 165 0.00218
(0.214) 		0.00633
(0.398) 		0.403
(0.804) 		9e-05
(0.0207) 		0.254
(0.76) 		0.237
(0.76) 		1
(1.00)
KRAS 52 (21%) 196 0.127
(0.76) 		0.000317
(0.0506) 		1
(1.00) 		0.00033
(0.0506) 		0.488
(0.85) 		0.496
(0.85) 		0.585
(0.896)
CTNNB1 74 (30%) 174 0.626
(0.91) 		0.000515
(0.0711) 		0.565
(0.896) 		1e-05
(0.00276) 		0.531
(0.875) 		0.735
(0.972) 		1
(1.00)
PIK3R1 82 (33%) 166 0.397
(0.803) 		0.349
(0.773) 		0.576
(0.896) 		1e-05
(0.00276) 		0.951
(1.00) 		0.117
(0.76) 		0.348
(0.773)
CTCF 44 (18%) 204 0.213
(0.76) 		0.0368
(0.659) 		0.864
(1.00) 		0.00024
(0.0473) 		0.894
(1.00) 		0.775
(0.98) 		1
(1.00)
PPP2R1A 28 (11%) 220 0.595
(0.896) 		0.00531
(0.366) 		0.679
(0.946) 		0.00088
(0.101) 		1
(1.00) 		0.618
(0.91) 		0.39
(0.8)
ARID5B 29 (12%) 219 0.62
(0.91) 		0.884
(1.00) 		0.0651
(0.76) 		0.00993
(0.414) 		0.0886
(0.76) 		0.00233
(0.214) 		0.483
(0.848)
WDR65 6 (2%) 242 0.442
(0.825) 		0.000997
(0.106) 		0.417
(0.815) 		0.635
(0.91) 		1
(1.00) 		0.739
(0.972) 		1
(1.00)
FBXW7 38 (15%) 210 0.989
(1.00) 		0.998
(1.00) 		0.584
(0.896) 		0.003
(0.259) 		0.48
(0.846) 		0.765
(0.976) 		1
(1.00)
PIK3CA 131 (53%) 117 0.0197
(0.578) 		0.156
(0.76) 		1
(1.00) 		0.282
(0.76) 		0.153
(0.76) 		0.73
(0.972) 		1
(1.00)
ARHGAP35 36 (15%) 212 0.855
(1.00) 		0.914
(1.00) 		0.457
(0.829) 		0.725
(0.972) 		0.926
(1.00) 		0.195
(0.76) 		0.533
(0.875)
ZFHX3 44 (18%) 204 0.506
(0.855) 		0.744
(0.972) 		0.0849
(0.76) 		0.0679
(0.76) 		0.438
(0.821) 		0.101
(0.76) 		0.187
(0.76)
SPOP 21 (8%) 227 0.308
(0.771) 		0.451
(0.829) 		0.811
(1.00) 		0.84
(1.00) 		0.569
(0.896) 		0.727
(0.972) 		0.37
(0.785)
FGFR2 31 (12%) 217 0.375
(0.786) 		0.983
(1.00) 		0.84
(1.00) 		0.776
(0.98) 		0.362
(0.777) 		0.616
(0.91) 		1
(1.00)
TCP11L2 14 (6%) 234 0.107
(0.76) 		0.988
(1.00) 		0.581
(0.896) 		0.172
(0.76) 		0.228
(0.76) 		0.0901
(0.76) 		0.284
(0.76)
VPS11 11 (4%) 237 0.557
(0.887) 		0.653
(0.923) 		0.541
(0.875) 		1
(1.00) 		1
(1.00) 		0.317
(0.773) 		1
(1.00)
MAX 9 (4%) 239 0.739
(0.972) 		0.271
(0.76) 		0.491
(0.85) 		0.457
(0.829) 		0.35
(0.773) 		0.408
(0.809) 		1
(1.00)
SOX17 7 (3%) 241 0.399
(0.803) 		0.452
(0.829) 		1
(1.00) 		0.428
(0.815) 		0.674
(0.942) 		0.0635
(0.76) 		1
(1.00)
CCND1 14 (6%) 234 0.525
(0.875) 		0.0652
(0.76) 		0.393
(0.803) 		0.172
(0.76) 		0.257
(0.76) 		0.755
(0.972) 		0.284
(0.76)
NRAS 9 (4%) 239 0.188
(0.76) 		0.785
(0.985) 		0.491
(0.85) 		1
(1.00) 		1
(1.00) 		0.042
(0.71) 		0.19
(0.76)
EP300 21 (8%) 227 0.327
(0.773) 		0.0984
(0.76) 		0.484
(0.848) 		0.0641
(0.76) 		1
(1.00) 		0.551
(0.884) 		0.0689
(0.76)
KLHL8 12 (5%) 236 0.17
(0.76) 		0.289
(0.76) 		0.765
(0.976) 		0.288
(0.76) 		0.212
(0.76) 		0.464
(0.834) 		0.214
(0.76)
ALG8 11 (4%) 237 0.782
(0.982) 		0.479
(0.845) 		0.751
(0.972) 		0.352
(0.773) 		0.591
(0.896) 		0.349
(0.773) 		0.0225
(0.597)
GNPTAB 20 (8%) 228 0.0944
(0.76) 		0.324
(0.773) 		0.146
(0.76) 		0.269
(0.76) 		0.575
(0.896) 		0.478
(0.845) 		0.328
(0.773)
SIN3A 21 (8%) 227 0.247
(0.76) 		0.159
(0.76) 		0.157
(0.76) 		0.279
(0.76) 		0.89
(1.00) 		0.0957
(0.76) 		1
(1.00)
NFE2L2 14 (6%) 234 0.551
(0.884) 		0.0928
(0.76) 		0.265
(0.76) 		0.17
(0.76) 		0.85
(1.00) 		0.498
(0.85) 		1
(1.00)
ZNF471 15 (6%) 233 0.959
(1.00) 		0.0355
(0.648) 		0.181
(0.76) 		0.14
(0.76) 		0.36
(0.777) 		0.0604
(0.76) 		0.284
(0.76)
MORC4 20 (8%) 228 0.0692
(0.76) 		0.0146
(0.48) 		0.811
(1.00) 		0.268
(0.76) 		1
(1.00) 		0.731
(0.972) 		0.328
(0.773)
SELP 10 (4%) 238 0.623
(0.91) 		0.314
(0.773) 		0.331
(0.773) 		0.335
(0.773) 		0.248
(0.76) 		0.0854
(0.76) 		0.19
(0.76)
RBMX 12 (5%) 236 0.811
(1.00) 		0.455
(0.829) 		0.765
(0.976) 		0.288
(0.76) 		0.0778
(0.76) 		0.193
(0.76) 		1
(1.00)
FAT1 40 (16%) 208 0.0146
(0.48) 		0.875
(1.00) 		0.859
(1.00) 		0.0434
(0.71) 		0.772
(0.98) 		0.404
(0.806) 		0.176
(0.76)
MARK3 11 (4%) 237 0.544
(0.875) 		0.0516
(0.728) 		0.751
(0.972) 		0.353
(0.773) 		0.198
(0.76) 		0.324
(0.773) 		0.164
(0.76)
SOS1 12 (5%) 236 0.195
(0.76) 		0.108
(0.76) 		1
(1.00) 		0.29
(0.76) 		0.835
(1.00) 		0.893
(1.00) 		1
(1.00)
RBBP6 22 (9%) 226 0.242
(0.76) 		0.988
(1.00) 		0.652
(0.923) 		0.0449
(0.71) 		0.497
(0.85) 		0.28
(0.76) 		1
(1.00)
ZNF263 7 (3%) 241 0.298
(0.771) 		0.0566
(0.76) 		1
(1.00) 		0.427
(0.815) 		0.201
(0.76) 		0.352
(0.773) 		0.0852
(0.76)
INTS7 8 (3%) 240 0.197
(0.76) 		0.536
(0.875) 		0.714
(0.972) 		0.436
(0.821) 		0.53
(0.875) 		0.176
(0.76) 		0.139
(0.76)
L1TD1 16 (6%) 232 0.139
(0.76) 		0.348
(0.773) 		0.424
(0.815) 		0.12
(0.76) 		0.878
(1.00) 		0.321
(0.773) 		0.284
(0.76)
NAT1 7 (3%) 241 0.815
(1.00) 		0.983
(1.00) 		1
(1.00) 		0.429
(0.815) 		0.466
(0.834) 		0.197
(0.76) 		1
(1.00)
JAKMIP2 12 (5%) 236 0.422
(0.815) 		0.0301
(0.638) 		0.543
(0.875) 		0.288
(0.76) 		0.259
(0.76) 		0.0291
(0.638) 		0.19
(0.76)
ING1 12 (5%) 236 0.232
(0.76) 		0.956
(1.00) 		0.765
(0.976) 		0.289
(0.76) 		1
(1.00) 		0.894
(1.00) 		1
(1.00)
CCDC6 6 (2%) 242 0.482
(0.848) 		0.749
(0.972) 		1
(1.00) 		0.362
(0.777) 		1
(1.00) 		0.53
(0.875) 		1
(1.00)
ZNF781 10 (4%) 238 0.299
(0.771) 		0.112
(0.76) 		0.0965
(0.76) 		0.336
(0.773) 		0.478
(0.845) 		0.712
(0.972) 		0.164
(0.76)
MKI67 29 (12%) 219 0.11
(0.76) 		0.499
(0.85) 		0.31
(0.771) 		0.0105
(0.414) 		0.232
(0.76) 		0.186
(0.76) 		0.465
(0.834)
EIF2S2 9 (4%) 239 0.26
(0.76) 		0.384
(0.791) 		0.491
(0.85) 		0.461
(0.831) 		0.337
(0.773) 		0.228
(0.76) 		0.19
(0.76)
BCOR 30 (12%) 218 0.0315
(0.638) 		0.0735
(0.76) 		0.428
(0.815) 		0.00849
(0.402) 		0.36
(0.777) 		0.0287
(0.638) 		1
(1.00)
RASA1 21 (8%) 227 0.063
(0.76) 		0.852
(1.00) 		0.241
(0.76) 		0.568
(0.896) 		1
(1.00) 		0.0739
(0.76) 		0.0611
(0.76)
DNER 18 (7%) 230 0.374
(0.786) 		0.0325
(0.638) 		1
(1.00) 		0.416
(0.815) 		0.626
(0.91) 		0.0991
(0.76) 		0.284
(0.76)
C9ORF23 9 (4%) 239 0.312
(0.772) 		0.588
(0.896) 		1
(1.00) 		0.457
(0.829) 		1
(1.00) 		1
(1.00) 		1
(1.00)
CUX1 21 (8%) 227 0.244
(0.76) 		0.114
(0.76) 		0.816
(1.00) 		0.275
(0.76) 		0.806
(1.00) 		0.237
(0.76) 		1
(1.00)
CDK17 14 (6%) 234 0.464
(0.834) 		0.0852
(0.76) 		0.265
(0.76) 		0.128
(0.76) 		0.271
(0.76) 		0.36
(0.777) 		0.262
(0.76)
USP28 10 (4%) 238 0.132
(0.76) 		0.502
(0.853) 		0.331
(0.773) 		0.333
(0.773) 		0.777
(0.98) 		0.352
(0.773) 		1
(1.00)
MSH6 17 (7%) 231 0.27
(0.76) 		0.124
(0.76) 		1
(1.00) 		0.492
(0.85) 		0.6
(0.896) 		0.573
(0.896) 		0.262
(0.76)
WDR45 11 (4%) 237 0.716
(0.972) 		0.551
(0.884) 		1
(1.00) 		0.352
(0.773) 		0.528
(0.875) 		0.0414
(0.71) 		1
(1.00)
C14ORF166B 9 (4%) 239 0.261
(0.76) 		0.589
(0.896) 		0.0284
(0.638) 		0.455
(0.829) 		1
(1.00) 		0.0846
(0.76) 		1
(1.00)
ATM 29 (12%) 219 0.0211
(0.588) 		0.265
(0.76) 		0.31
(0.771) 		0.0757
(0.76) 		0.904
(1.00) 		0.218
(0.76) 		0.447
(0.829)
RAE1 11 (4%) 237 0.199
(0.76) 		0.729
(0.972) 		0.0584
(0.76) 		0.744
(0.972) 		1
(1.00) 		0.315
(0.773) 		1
(1.00)
ZNF485 9 (4%) 239 0.955
(1.00) 		0.361
(0.777) 		0.16
(0.76) 		0.453
(0.829) 		0.0703
(0.76) 		0.227
(0.76) 		0.214
(0.76)
POLE 27 (11%) 221 0.362
(0.777) 		0.552
(0.884) 		0.291
(0.76) 		0.127
(0.76) 		0.398
(0.803) 		0.373
(0.786) 		0.429
(0.815)
AHCYL1 6 (2%) 242 0.316
(0.773) 		0.0311
(0.638) 		1
(1.00) 		0.633
(0.91) 		0.401
(0.803) 		0.171
(0.76) 		0.0852
(0.76)
ZNF334 17 (7%) 231 0.538
(0.875) 		0.00468
(0.339) 		0.608
(0.904) 		0.807
(1.00) 		0.601
(0.896) 		0.73
(0.972) 		0.307
(0.771)
SACS 26 (10%) 222 0.12
(0.76) 		0.855
(1.00) 		0.528
(0.875) 		0.118
(0.76) 		0.626
(0.91) 		0.0491
(0.71) 		0.00718
(0.398)
MSH4 15 (6%) 233 0.108
(0.76) 		0.155
(0.76) 		0.582
(0.896) 		0.138
(0.76) 		0.63
(0.91) 		0.069
(0.76) 		0.262
(0.76)
SLC26A8 12 (5%) 236 0.214
(0.76) 		0.0329
(0.638) 		0.543
(0.875) 		0.289
(0.76) 		0.685
(0.949) 		0.399
(0.803) 		0.238
(0.76)
KIF20B 21 (8%) 227 0.0809
(0.76) 		0.142
(0.76) 		0.484
(0.848) 		0.0646
(0.76) 		0.905
(1.00) 		0.553
(0.884) 		0.307
(0.771)
RRAS2 4 (2%) 244 0.497
(0.85) 		0.0213
(0.588) 		0.628
(0.91) 		1
(1.00) 		0.427
(0.815) 		1
(1.00) 		1
(1.00)
CTNND1 19 (8%) 229 0.766
(0.976) 		0.411
(0.812) 		1
(1.00) 		0.426
(0.815) 		0.381
(0.79) 		0.507
(0.856) 		1
(1.00)
NFE2L3 12 (5%) 236 0.561
(0.892) 		0.781
(0.98) 		0.368
(0.785) 		0.22
(0.76) 		0.408
(0.809) 		0.204
(0.76) 		1
(1.00)
FAM65B 16 (6%) 232 0.115
(0.76) 		0.049
(0.71) 		0.791
(0.989) 		0.476
(0.845) 		0.863
(1.00) 		0.247
(0.76) 		0.262
(0.76)
RNF43 12 (5%) 236 0.16
(0.76) 		0.671
(0.941) 		0.0357
(0.648) 		0.289
(0.76) 		0.64
(0.911) 		0.295
(0.767) 		1
(1.00)
MRPL47 6 (2%) 242 0.417
(0.815) 		0.92
(1.00) 		0.417
(0.815) 		1
(1.00) 		0.464
(0.834) 		1
(1.00) 		0.112
(0.76)
TIGD4 13 (5%) 235 0.176
(0.76) 		0.0517
(0.728) 		0.772
(0.98) 		0.301
(0.771) 		0.593
(0.896) 		0.476
(0.845) 		0.262
(0.76)
FILIP1 16 (6%) 232 0.0888
(0.76) 		0.596
(0.896) 		0.598
(0.896) 		0.477
(0.845) 		0.591
(0.896) 		0.804
(1.00) 		0.214
(0.76)
SLC1A3 12 (5%) 236 0.603
(0.899) 		0.755
(0.972) 		1
(1.00) 		1
(1.00) 		0.637
(0.911) 		0.00772
(0.398) 		1
(1.00)
UFSP2 11 (4%) 237 0.167
(0.76) 		1
(1.00) 		1
(1.00) 		0.353
(0.773) 		0.687
(0.949) 		0.754
(0.972) 		0.19
(0.76)
WBP4 8 (3%) 240 0.359
(0.777) 		0.133
(0.76) 		0.264
(0.76) 		0.437
(0.821) 		1
(1.00) 		1
(1.00) 		1
(1.00)
TRIM59 9 (4%) 239 0.271
(0.76) 		0.876
(1.00) 		0.491
(0.85) 		0.456
(0.829) 		1
(1.00) 		0.0396
(0.701) 		1
(1.00)
RSBN1L 12 (5%) 236 0.127
(0.76) 		0.291
(0.76) 		0.543
(0.875) 		0.753
(0.972) 		0.158
(0.76) 		0.00331
(0.268) 		0.238
(0.76)
SERHL2 6 (2%) 242 0.248
(0.76) 		0.699
(0.964) 		0.198
(0.76) 		0.633
(0.91) 		1
(1.00) 		1
(1.00) 		1
(1.00)
OR52I2 8 (3%) 240 0.774
(0.98) 		0.679
(0.946) 		1
(1.00) 		0.156
(0.76) 		0.778
(0.98) 		0.351
(0.773) 		1
(1.00)
SGK1 13 (5%) 235 0.592
(0.896) 		0.426
(0.815) 		1
(1.00) 		0.575
(0.896) 		0.0469
(0.71) 		0.299
(0.771) 		1
(1.00)
LNX2 14 (6%) 234 0.141
(0.76) 		0.843
(1.00) 		0.0889
(0.76) 		0.169
(0.76) 		0.764
(0.976) 		0.182
(0.76) 		0.284
(0.76)
ALPK2 19 (8%) 229 0.0473
(0.71) 		0.233
(0.76) 		0.334
(0.773) 		0.429
(0.815) 		0.239
(0.76) 		0.126
(0.76) 		0.307
(0.771)
REV3L 20 (8%) 228 0.0774
(0.76) 		0.503
(0.853) 		0.335
(0.773) 		0.0681
(0.76) 		0.916
(1.00) 		0.144
(0.76) 		0.328
(0.773)
CAB39L 8 (3%) 240 0.253
(0.76) 		0.789
(0.988) 		0.264
(0.76) 		0.438
(0.821) 		1
(1.00) 		0.00914
(0.404) 		1
(1.00)
ERBB3 17 (7%) 231 0.133
(0.76) 		0.598
(0.896) 		0.796
(0.994) 		0.492
(0.85) 		0.274
(0.76) 		0.0885
(0.76) 		1
(1.00)
INPP4B 12 (5%) 236 0.519
(0.87) 		0.178
(0.76) 		0.0044
(0.337) 		0.29
(0.76) 		0.166
(0.76) 		0.142
(0.76) 		0.238
(0.76)
C1ORF100 9 (4%) 239 0.151
(0.76) 		0.139
(0.76) 		1
(1.00) 		0.458
(0.829) 		0.466
(0.834) 		0.354
(0.773) 		0.112
(0.76)
IL20 7 (3%) 241 0.255
(0.76) 		0.169
(0.76) 		0.712
(0.972) 		0.428
(0.815) 		0.103
(0.76) 		0.0128
(0.464) 		0.112
(0.76)
SLC44A3 6 (2%) 242 0.305
(0.771) 		0.0571
(0.76) 		1
(1.00) 		0.635
(0.91) 		0.606
(0.902) 		0.425
(0.815) 		1
(1.00)
TAP1 8 (3%) 240 0.646
(0.917) 		0.942
(1.00) 		0.714
(0.972) 		0.437
(0.821) 		1
(1.00) 		0.398
(0.803) 		1
(1.00)
RHBDD3 4 (2%) 244 0.392
(0.803) 		0.128
(0.76) 		0.628
(0.91) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		1
(1.00)
BRDT 14 (6%) 234 0.146
(0.76) 		0.0842
(0.76) 		0.0889
(0.76) 		0.172
(0.76) 		0.634
(0.91) 		0.185
(0.76) 		0.238
(0.76)
RB1 20 (8%) 228 0.221
(0.76) 		0.124
(0.76) 		0.146
(0.76) 		0.0682
(0.76) 		0.867
(1.00) 		0.0768
(0.76) 		1
(1.00)
MFAP5 9 (4%) 239 0.263
(0.76) 		0.0104
(0.414) 		1
(1.00) 		1
(1.00) 		0.528
(0.875) 		0.565
(0.896) 		0.164
(0.76)
NAA15 14 (6%) 234 0.366
(0.782) 		0.991
(1.00) 		0.777
(0.98) 		0.586
(0.896) 		0.761
(0.976) 		0.232
(0.76) 		0.238
(0.76)
ZRANB3 7 (3%) 241 0.22
(0.76) 		0.499
(0.85) 		0.712
(0.972) 		1
(1.00) 		1
(1.00) 		0.198
(0.76) 		1
(1.00)
SLC34A3 6 (2%) 242 0.388
(0.798) 		0.108
(0.76) 		0.673
(0.941) 		0.632
(0.91) 		1
(1.00) 		0.228
(0.76) 		1
(1.00)
MLH3 17 (7%) 231 0.45
(0.829) 		0.00875
(0.402) 		0.608
(0.904) 		0.494
(0.85) 		0.239
(0.76) 		0.171
(0.76) 		0.307
(0.771)
CCDC147 15 (6%) 233 0.153
(0.76) 		0.0312
(0.638) 		0.181
(0.76) 		0.472
(0.841) 		0.595
(0.896) 		0.276
(0.76) 		0.238
(0.76)
ZNF662 13 (5%) 235 0.126
(0.76) 		0.493
(0.85) 		0.772
(0.98) 		0.577
(0.896) 		0.637
(0.911) 		0.275
(0.76) 		0.214
(0.76)
PSMC4 11 (4%) 237 0.223
(0.76) 		0.831
(1.00) 		1
(1.00) 		0.352
(0.773) 		0.851
(1.00) 		0.148
(0.76) 		1
(1.00)
CCDC160 11 (4%) 237 0.165
(0.76) 		0.204
(0.76) 		0.751
(0.972) 		0.35
(0.773) 		0.833
(1.00) 		0.4
(0.803) 		1
(1.00)
PPIL4 11 (4%) 237 0.227
(0.76) 		0.86
(1.00) 		0.541
(0.875) 		0.746
(0.972) 		0.592
(0.896) 		1
(1.00) 		0.214
(0.76)
CCDC144A 18 (7%) 230 0.393
(0.803) 		0.128
(0.76) 		0.212
(0.76) 		0.661
(0.932) 		0.295
(0.767) 		0.0357
(0.648) 		0.307
(0.771)
TUBGCP6 20 (8%) 228 0.495
(0.85) 		0.328
(0.773) 		0.631
(0.91) 		0.0678
(0.76) 		0.379
(0.789) 		0.22
(0.76) 		1
(1.00)
TTC39C 7 (3%) 241 0.283
(0.76) 		0.344
(0.773) 		0.0487
(0.71) 		0.424
(0.815) 		1
(1.00) 		0.599
(0.896) 		1
(1.00)
COL8A1 10 (4%) 238 0.245
(0.76) 		0.864
(1.00) 		1
(1.00) 		0.335
(0.773) 		0.47
(0.839) 		0.46
(0.831) 		0.112
(0.76)
PER3 12 (5%) 236 0.172
(0.76) 		0.521
(0.873) 		0.543
(0.875) 		0.289
(0.76) 		1
(1.00) 		0.557
(0.887) 		1
(1.00)
MGA 26 (10%) 222 0.683
(0.949) 		0.67
(0.941) 		0.834
(1.00) 		0.35
(0.773) 		0.149
(0.76) 		0.351
(0.773) 		0.349
(0.773)
GPRASP1 21 (8%) 227 0.241
(0.76) 		0.17
(0.76) 		0.816
(1.00) 		0.278
(0.76) 		0.587
(0.896) 		0.675
(0.942) 		0.328
(0.773)
PPM1D 11 (4%) 237 0.195
(0.76) 		0.351
(0.773) 		0.0584
(0.76) 		0.353
(0.773) 		0.585
(0.896) 		0.251
(0.76) 		0.19
(0.76)
ZNF674 14 (6%) 234 0.0977
(0.76) 		0.101
(0.76) 		0.581
(0.896) 		0.585
(0.896) 		0.515
(0.865) 		0.192
(0.76) 		1
(1.00)
LIMK2 12 (5%) 236 0.241
(0.76) 		0.781
(0.98) 		0.543
(0.875) 		0.751
(0.972) 		0.687
(0.949) 		0.316
(0.773) 		0.214
(0.76)
ZNF606 16 (6%) 232 0.354
(0.773) 		0.446
(0.829) 		0.18
(0.76) 		0.121
(0.76) 		0.495
(0.85) 		0.129
(0.76) 		0.0336
(0.638)
SFRP4 8 (3%) 240 0.218
(0.76) 		0.124
(0.76) 		0.714
(0.972) 		0.439
(0.822) 		0.338
(0.773) 		0.341
(0.773) 		0.139
(0.76)
TXNRD1 8 (3%) 240 0.141
(0.76) 		0.632
(0.91) 		0.264
(0.76) 		0.436
(0.821) 		0.352
(0.773) 		0.824
(1.00) 		1
(1.00)
LETMD1 6 (2%) 242 0.225
(0.76) 		0.888
(1.00) 		1
(1.00) 		0.634
(0.91) 		0.054
(0.752) 		0.114
(0.76) 		0.112
(0.76)
ZNF721 13 (5%) 235 0.187
(0.76) 		0.0494
(0.71) 		0.383
(0.79) 		0.302
(0.771) 		0.632
(0.91) 		0.183
(0.76) 		0.238
(0.76)
RASSF9 9 (4%) 239 0.244
(0.76) 		0.0134
(0.475) 		0.16
(0.76) 		0.456
(0.829) 		0.586
(0.896) 		0.168
(0.76) 		0.164
(0.76)
AGXT2 11 (4%) 237 0.667
(0.938) 		0.168
(0.76) 		0.751
(0.972) 		0.352
(0.773) 		0.631
(0.91) 		0.51
(0.86) 		0.19
(0.76)
MECOM 12 (5%) 236 0.12
(0.76) 		0.0117
(0.435) 		0.543
(0.875) 		0.289
(0.76) 		1
(1.00) 		0.809
(1.00) 		1
(1.00)
ATP6V1C2 12 (5%) 236 0.148
(0.76) 		0.033
(0.638) 		1
(1.00) 		0.291
(0.76) 		0.835
(1.00) 		0.184
(0.76) 		1
(1.00)
DYM 10 (4%) 238 0.279
(0.76) 		0.732
(0.972) 		0.749
(0.972) 		0.741
(0.972) 		1
(1.00) 		0.579
(0.896) 		1
(1.00)
TAB3 18 (7%) 230 0.0852
(0.76) 		0.0402
(0.702) 		0.458
(0.829) 		0.0876
(0.76) 		0.259
(0.76) 		0.0316
(0.638) 		0.37
(0.785)
ZNF649 14 (6%) 234 0.138
(0.76) 		0.185
(0.76) 		0.265
(0.76) 		0.17
(0.76) 		0.764
(0.976) 		0.907
(1.00) 		0.238
(0.76)
FN1 24 (10%) 224 0.217
(0.76) 		0.779
(0.98) 		0.825
(1.00) 		0.0224
(0.597) 		0.375
(0.786) 		0.778
(0.98) 		0.429
(0.815)
CCDC150 11 (4%) 237 0.291
(0.76) 		0.8
(0.998) 		0.751
(0.972) 		0.743
(0.972) 		0.85
(1.00) 		0.876
(1.00) 		1
(1.00)
KIF21A 15 (6%) 233 0.13
(0.76) 		0.329
(0.773) 		0.0564
(0.76) 		0.141
(0.76) 		0.591
(0.896) 		0.378
(0.789) 		0.262
(0.76)
BHLHB9 8 (3%) 240 0.243
(0.76) 		0.398
(0.803) 		1
(1.00) 		0.437
(0.821) 		0.733
(0.972) 		0.402
(0.803) 		1
(1.00)
EXOSC9 10 (4%) 238 0.264
(0.76) 		0.78
(0.98) 		0.331
(0.773) 		0.334
(0.773) 		0.589
(0.896) 		0.406
(0.808) 		0.19
(0.76)
ZKSCAN1 7 (3%) 241 0.357
(0.777) 		0.968
(1.00) 		0.712
(0.972) 		1
(1.00) 		0.732
(0.972) 		0.597
(0.896) 		1
(1.00)
OR8B8 7 (3%) 241 0.302
(0.771) 		0.0145
(0.48) 		0.265
(0.76) 		0.425
(0.815) 		0.398
(0.803) 		0.286
(0.76) 		0.139
(0.76)
SENP7 12 (5%) 236 0.429
(0.815) 		0.609
(0.904) 		0.543
(0.875) 		0.288
(0.76) 		0.685
(0.949) 		0.554
(0.884) 		1
(1.00)
NRIP1 13 (5%) 235 0.456
(0.829) 		0.117
(0.76) 		0.383
(0.79) 		0.577
(0.896) 		0.407
(0.808) 		0.357
(0.777) 		1
(1.00)
MCTP1 13 (5%) 235 0.153
(0.76) 		0.0153
(0.481) 		1
(1.00) 		0.575
(0.896) 		0.636
(0.91) 		0.478
(0.845) 		0.238
(0.76)
CCDC146 14 (6%) 234 0.15
(0.76) 		0.033
(0.638) 		0.0889
(0.76) 		0.171
(0.76) 		0.636
(0.91) 		0.231
(0.76) 		0.238
(0.76)
ZNF620 9 (4%) 239 0.262
(0.76) 		0.0254
(0.638) 		0.491
(0.85) 		0.458
(0.829) 		0.731
(0.972) 		0.709
(0.972) 		1
(1.00)
PTPN12 10 (4%) 238 0.766
(0.976) 		0.829
(1.00) 		0.331
(0.773) 		0.336
(0.773) 		0.587
(0.896) 		0.231
(0.76) 		0.19
(0.76)
RIOK3 9 (4%) 239 0.262
(0.76) 		0.364
(0.779) 		0.16
(0.76) 		0.457
(0.829) 		1
(1.00) 		0.409
(0.809) 		1
(1.00)
CASP8 17 (7%) 231 0.926
(1.00) 		0.748
(0.972) 		0.791
(0.989) 		0.488
(0.85) 		0.525
(0.875) 		0.0283
(0.638) 		0.0465
(0.71)
GFAP 6 (2%) 242 0.373
(0.786) 		0.142
(0.76) 		1
(1.00) 		0.633
(0.91) 		0.324
(0.773) 		0.672
(0.941) 		0.0852
(0.76)
OMA1 10 (4%) 238 0.265
(0.76) 		0.09
(0.76) 		0.0965
(0.76) 		0.335
(0.773) 		0.529
(0.875) 		0.278
(0.76) 		0.164
(0.76)
DENND3 15 (6%) 233 0.365
(0.779) 		0.123
(0.76) 		0.423
(0.815) 		0.472
(0.841) 		0.878
(1.00) 		0.158
(0.76) 		0.0336
(0.638)
CHEK2 12 (5%) 236 0.65
(0.922) 		0.015
(0.48) 		0.219
(0.76) 		0.753
(0.972) 		0.134
(0.76) 		0.399
(0.803) 		0.19
(0.76)
ZMYM2 17 (7%) 231 0.323
(0.773) 		0.0287
(0.638) 		0.302
(0.771) 		0.0994
(0.76) 		0.662
(0.932) 		0.277
(0.76) 		1
(1.00)
EPC2 5 (2%) 243 0.296
(0.768) 		0.639
(0.911) 		0.654
(0.923) 		0.618
(0.91) 		1
(1.00) 		0.17
(0.76) 		1
(1.00)
DEPDC1B 11 (4%) 237 0.872
(1.00) 		0.592
(0.896) 		1
(1.00) 		0.744
(0.972) 		0.158
(0.76) 		0.0481
(0.71) 		1
(1.00)
C3AR1 7 (3%) 241 0.195
(0.76) 		0.802
(0.999) 		1
(1.00) 		0.43
(0.815) 		0.531
(0.875) 		0.126
(0.76) 		0.139
(0.76)
STK3 10 (4%) 238 0.202
(0.76) 		0.0478
(0.71) 		0.506
(0.855) 		0.335
(0.773) 		1
(1.00) 		0.125
(0.76) 		1
(1.00)
FOXJ3 10 (4%) 238 0.221
(0.76) 		0.512
(0.862) 		0.749
(0.972) 		0.335
(0.773) 		0.64
(0.911) 		0.085
(0.76) 		0.214
(0.76)
EPS8 12 (5%) 236 0.741
(0.972) 		0.124
(0.76) 		1
(1.00) 		0.753
(0.972) 		0.684
(0.949) 		0.399
(0.803) 		0.238
(0.76)
ZNF385B 7 (3%) 241 0.359
(0.777) 		0.204
(0.76) 		0.265
(0.76) 		0.426
(0.815) 		1
(1.00) 		0.5
(0.85) 		1
(1.00)
EFCAB4B 11 (4%) 237 0.155
(0.76) 		0.0206
(0.588) 		0.751
(0.972) 		0.352
(0.773) 		0.338
(0.773) 		0.0239
(0.622) 		0.19
(0.76)
NPRL2 5 (2%) 243 0.946
(1.00) 		0.816
(1.00) 		0.654
(0.923) 		0.619
(0.91) 		0.246
(0.76) 		1
(1.00) 		1
(1.00)
ATF6 14 (6%) 234 0.117
(0.76) 		0.309
(0.771) 		1
(1.00) 		0.582
(0.896) 		0.633
(0.91) 		0.334
(0.773) 		0.238
(0.76)
LIMA1 8 (3%) 240 0.213
(0.76) 		0.888
(1.00) 		0.714
(0.972) 		0.438
(0.821) 		1
(1.00) 		0.659
(0.929) 		1
(1.00)
PPIG 16 (6%) 232 0.162
(0.76) 		0.0726
(0.76) 		0.598
(0.896) 		0.121
(0.76) 		0.904
(1.00) 		0.932
(1.00) 		0.284
(0.76)
ZNF774 10 (4%) 238 0.213
(0.76) 		0.581
(0.896) 		0.749
(0.972) 		0.744
(0.972) 		0.587
(0.896) 		0.709
(0.972) 		0.164
(0.76)
MUTED 7 (3%) 241 0.307
(0.771) 		0.748
(0.972) 		0.265
(0.76) 		0.426
(0.815) 		1
(1.00) 		0.0943
(0.76) 		1
(1.00)
TPX2 6 (2%) 242 0.378
(0.789) 		0.0114
(0.435) 		1
(1.00) 		0.631
(0.91) 		0.135
(0.76) 		0.673
(0.941) 		0.0852
(0.76)
PARG 9 (4%) 239 0.244
(0.76) 		0.554
(0.884) 		1
(1.00) 		0.457
(0.829) 		1
(1.00) 		0.709
(0.972) 		1
(1.00)
PSMD3 11 (4%) 237 0.16
(0.76) 		0.373
(0.786) 		1
(1.00) 		0.746
(0.972) 		1
(1.00) 		0.402
(0.803) 		1
(1.00)
STRN3 12 (5%) 236 0.208
(0.76) 		0.28
(0.76) 		0.543
(0.875) 		0.752
(0.972) 		0.591
(0.896) 		0.343
(0.773) 		0.238
(0.76)
MLL4 30 (12%) 218 0.0308
(0.638) 		0.245
(0.76) 		0.693
(0.956) 		0.0443
(0.71) 		0.571
(0.896) 		0.293
(0.764) 		0.5
(0.85)
MSN 15 (6%) 233 0.34
(0.773) 		0.273
(0.76) 		1
(1.00) 		0.597
(0.896) 		0.485
(0.848) 		0.0177
(0.542) 		0.238
(0.76)
MAPK8 11 (4%) 237 0.159
(0.76) 		0.775
(0.98) 		0.221
(0.76) 		0.353
(0.773) 		0.308
(0.771) 		0.318
(0.773) 		1
(1.00)
RBL2 12 (5%) 236 0.527
(0.875) 		0.211
(0.76) 		1
(1.00) 		0.287
(0.76) 		0.154
(0.76) 		0.149
(0.76) 		0.238
(0.76)
PDGFRA 12 (5%) 236 0.14
(0.76) 		0.181
(0.76) 		0.543
(0.875) 		0.289
(0.76) 		1
(1.00) 		0.478
(0.845) 		1
(1.00)
TMEM62 9 (4%) 239 0.309
(0.771) 		0.506
(0.855) 		0.491
(0.85) 		0.454
(0.829) 		0.588
(0.896) 		0.351
(0.773) 		0.19
(0.76)
RG9MTD3 8 (3%) 240 0.756
(0.972) 		0.72
(0.972) 		0.264
(0.76) 		0.684
(0.949) 		0.352
(0.773) 		0.565
(0.896) 		1
(1.00)
KANK4 11 (4%) 237 0.899
(1.00) 		0.043
(0.71) 		0.751
(0.972) 		0.748
(0.972) 		1
(1.00) 		0.511
(0.861) 		1
(1.00)
MYOM1 23 (9%) 225 0.53
(0.875) 		0.228
(0.76) 		1
(1.00) 		0.848
(1.00) 		0.441
(0.825) 		0.106
(0.76) 		0.37
(0.785)
MORC3 10 (4%) 238 0.202
(0.76) 		0.108
(0.76) 		1
(1.00) 		0.741
(0.972) 		0.398
(0.803) 		0.754
(0.972) 		1
(1.00)
CCDC82 12 (5%) 236 0.179
(0.76) 		0.769
(0.98) 		0.543
(0.875) 		0.288
(0.76) 		0.593
(0.896) 		0.876
(1.00) 		0.19
(0.76)
B3GALT5 4 (2%) 244 0.532
(0.875) 		0.104
(0.76) 		0.3
(0.771) 		1
(1.00) 		1
(1.00) 		0.374
(0.786) 		1
(1.00)
NOC3L 11 (4%) 237 0.186
(0.76) 		0.379
(0.789) 		0.221
(0.76) 		0.352
(0.773) 		0.642
(0.913) 		0.0971
(0.76) 		0.19
(0.76)
NSUN4 6 (2%) 242 0.377
(0.789) 		0.721
(0.972) 		0.417
(0.815) 		1
(1.00) 		0.61
(0.904) 		0.227
(0.76) 		0.112
(0.76)
ASXL2 14 (6%) 234 0.122
(0.76) 		0.381
(0.79) 		0.581
(0.896) 		0.587
(0.896) 		0.204
(0.76) 		0.522
(0.874) 		0.214
(0.76)
CHD4 35 (14%) 213 0.829
(1.00) 		0.425
(0.815) 		0.345
(0.773) 		0.452
(0.829) 		1
(1.00) 		0.735
(0.972) 		1
(1.00)
FCN1 7 (3%) 241 0.878
(1.00) 		0.82
(1.00) 		1
(1.00) 		0.428
(0.815) 		1
(1.00) 		0.124
(0.76) 		1
(1.00)
NIPA2 8 (3%) 240 0.311
(0.772) 		0.986
(1.00) 		0.714
(0.972) 		1
(1.00) 		1
(1.00) 		0.0338
(0.638) 		1
(1.00)
C14ORF118 13 (5%) 235 0.198
(0.76) 		0.00808
(0.398) 		0.14
(0.76) 		0.304
(0.771) 		0.727
(0.972) 		0.388
(0.798) 		0.214
(0.76)
THAP5 6 (2%) 242 0.347
(0.773) 		0.115
(0.76) 		0.0875
(0.76) 		0.634
(0.91) 		1
(1.00) 		0.288
(0.76) 		1
(1.00)
ZNF611 12 (5%) 236 0.732
(0.972) 		0.244
(0.76) 		1
(1.00) 		0.288
(0.76) 		0.165
(0.76) 		0.207
(0.76) 		0.238
(0.76)
ZCCHC18 6 (2%) 242 0.379
(0.789) 		0.943
(1.00) 		0.0875
(0.76) 		0.633
(0.91) 		1
(1.00) 		0.534
(0.875) 		1
(1.00)
PRKCE 9 (4%) 239 0.201
(0.76) 		0.996
(1.00) 		0.729
(0.972) 		0.457
(0.829) 		1
(1.00) 		0.457
(0.829) 		1
(1.00)
BMP2K 13 (5%) 235 0.178
(0.76) 		0.904
(1.00) 		0.383
(0.79) 		0.3
(0.771) 		0.686
(0.949) 		0.73
(0.972) 		0.238
(0.76)
PRPF38B 11 (4%) 237 0.245
(0.76) 		0.397
(0.803) 		0.751
(0.972) 		0.353
(0.773) 		0.638
(0.911) 		0.753
(0.972) 		0.214
(0.76)
LGMN 7 (3%) 241 0.28
(0.76) 		0.987
(1.00) 		0.712
(0.972) 		0.425
(0.815) 		0.281
(0.76) 		1
(1.00) 		1
(1.00)
SSH2 12 (5%) 236 0.213
(0.76) 		0.208
(0.76) 		0.543
(0.875) 		0.752
(0.972) 		0.592
(0.896) 		0.00801
(0.398) 		0.0278
(0.638)
EMR1 11 (4%) 237 0.212
(0.76) 		0.13
(0.76) 		0.221
(0.76) 		0.354
(0.773) 		0.584
(0.896) 		0.755
(0.972) 		0.19
(0.76)
OR5AK2 5 (2%) 243 0.261
(0.76) 		0.21
(0.76) 		0.654
(0.923) 		0.623
(0.91) 		0.326
(0.773) 		0.0684
(0.76) 		0.0852
(0.76)
C1ORF101 12 (5%) 236 0.198
(0.76) 		0.0191
(0.571) 		0.543
(0.875) 		0.288
(0.76) 		0.728
(0.972) 		0.149
(0.76) 		0.238
(0.76)
ZNF534 9 (4%) 239 0.288
(0.76) 		0.317
(0.773) 		0.491
(0.85) 		0.455
(0.829) 		0.585
(0.896) 		0.272
(0.76) 		0.19
(0.76)
FAM122A 6 (2%) 242 0.896
(1.00) 		0.991
(1.00) 		1
(1.00) 		0.631
(0.91) 		0.282
(0.76) 		0.532
(0.875) 		1
(1.00)
'PTEN MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.0028

Table S1.  Gene #1: 'PTEN MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
PTEN MUTATED 159 1 1
PTEN WILD-TYPE 41 3 43

Figure S1.  Get High-res Image Gene #1: 'PTEN MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'PTEN MUTATION STATUS' versus 'RACE'

P value = 0.00066 (Fisher's exact test), Q value = 0.083

Table S2.  Gene #1: 'PTEN MUTATION STATUS' versus Clinical Feature #6: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER WHITE
ALL 3 13 25 7 194
PTEN MUTATED 3 10 7 4 133
PTEN WILD-TYPE 0 3 18 3 61

Figure S2.  Get High-res Image Gene #1: 'PTEN MUTATION STATUS' versus Clinical Feature #6: 'RACE'

'PIK3R1 MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.0028

Table S3.  Gene #2: 'PIK3R1 MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
PIK3R1 MUTATED 79 1 2
PIK3R1 WILD-TYPE 121 3 42

Figure S3.  Get High-res Image Gene #2: 'PIK3R1 MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'TP53 MUTATION STATUS' versus 'YEARS_TO_BIRTH'

P value = 5.85e-06 (Wilcoxon-test), Q value = 0.0028

Table S4.  Gene #3: 'TP53 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 248 63.1 (11.1)
TP53 MUTATED 69 67.9 (9.4)
TP53 WILD-TYPE 179 61.3 (11.2)

Figure S4.  Get High-res Image Gene #3: 'TP53 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'TP53 MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.0028

Table S5.  Gene #3: 'TP53 MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
TP53 MUTATED 27 3 39
TP53 WILD-TYPE 173 1 5

Figure S5.  Get High-res Image Gene #3: 'TP53 MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'CTCF MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 0.00024 (Fisher's exact test), Q value = 0.047

Table S6.  Gene #4: 'CTCF MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
CTCF MUTATED 44 0 0
CTCF WILD-TYPE 156 4 44

Figure S6.  Get High-res Image Gene #4: 'CTCF MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'ARID1A MUTATION STATUS' versus 'Time to Death'

P value = 0.00218 (logrank test), Q value = 0.21

Table S7.  Gene #7: 'ARID1A MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 248 29 0.6 - 185.8 (34.6)
ARID1A MUTATED 83 2 1.0 - 129.8 (36.1)
ARID1A WILD-TYPE 165 27 0.6 - 185.8 (31.1)

Figure S7.  Get High-res Image Gene #7: 'ARID1A MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'

'ARID1A MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 9e-05 (Fisher's exact test), Q value = 0.021

Table S8.  Gene #7: 'ARID1A MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
ARID1A MUTATED 78 1 4
ARID1A WILD-TYPE 122 3 40

Figure S8.  Get High-res Image Gene #7: 'ARID1A MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'KRAS MUTATION STATUS' versus 'YEARS_TO_BIRTH'

P value = 0.000317 (Wilcoxon-test), Q value = 0.051

Table S9.  Gene #9: 'KRAS MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 248 63.1 (11.1)
KRAS MUTATED 52 58.6 (8.7)
KRAS WILD-TYPE 196 64.3 (11.4)

Figure S9.  Get High-res Image Gene #9: 'KRAS MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'KRAS MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 0.00033 (Fisher's exact test), Q value = 0.051

Table S10.  Gene #9: 'KRAS MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
KRAS MUTATED 51 0 1
KRAS WILD-TYPE 149 4 43

Figure S10.  Get High-res Image Gene #9: 'KRAS MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'CTNNB1 MUTATION STATUS' versus 'YEARS_TO_BIRTH'

P value = 0.000515 (Wilcoxon-test), Q value = 0.071

Table S11.  Gene #10: 'CTNNB1 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 248 63.1 (11.1)
CTNNB1 MUTATED 74 59.6 (11.6)
CTNNB1 WILD-TYPE 174 64.6 (10.6)

Figure S11.  Get High-res Image Gene #10: 'CTNNB1 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'CTNNB1 MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.0028

Table S12.  Gene #10: 'CTNNB1 MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
CTNNB1 MUTATED 74 0 0
CTNNB1 WILD-TYPE 126 4 44

Figure S12.  Get High-res Image Gene #10: 'CTNNB1 MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'PPP2R1A MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 0.00088 (Fisher's exact test), Q value = 0.1

Table S13.  Gene #16: 'PPP2R1A MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
PPP2R1A MUTATED 15 1 12
PPP2R1A WILD-TYPE 185 3 32

Figure S13.  Get High-res Image Gene #16: 'PPP2R1A MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'ARID5B MUTATION STATUS' versus 'RACE'

P value = 0.00233 (Fisher's exact test), Q value = 0.21

Table S14.  Gene #26: 'ARID5B MUTATION STATUS' versus Clinical Feature #6: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER WHITE
ALL 3 13 25 7 194
ARID5B MUTATED 1 5 0 2 20
ARID5B WILD-TYPE 2 8 25 5 174

Figure S14.  Get High-res Image Gene #26: 'ARID5B MUTATION STATUS' versus Clinical Feature #6: 'RACE'

'WDR65 MUTATION STATUS' versus 'YEARS_TO_BIRTH'

P value = 0.000997 (Wilcoxon-test), Q value = 0.11

Table S15.  Gene #135: 'WDR65 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 248 63.1 (11.1)
WDR65 MUTATED 6 48.5 (8.1)
WDR65 WILD-TYPE 242 63.5 (10.9)

Figure S15.  Get High-res Image Gene #135: 'WDR65 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

Methods & Data
Input

  • Mutation data file = sample_sig_gene_table.txt from Mutsig_2CV pipeline

  • Processed Mutation data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/UCEC-TP/20217348/transformed.cor.cli.txt

  • Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/UCEC-TP/19775642/UCEC-TP.merged_data.txt

  • Number of patients = 248

  • Number of significantly mutated genes = 197

  • Number of selected clinical features = 7

  • Exclude genes that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[3] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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