This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.
Testing the association between mutation status of 60 genes and 15 clinical features across 185 patients, 13 significant findings detected with Q value < 0.25.
-
TP53 mutation correlated to 'YEARS_TO_BIRTH', 'HISTOLOGICAL_TYPE', and 'RACE'.
-
NFE2L2 mutation correlated to 'HISTOLOGICAL_TYPE' and 'RACE'.
-
ERBB2 mutation correlated to 'HISTOLOGICAL_TYPE'.
-
KIAA2018 mutation correlated to 'YEARS_TO_BIRTH' and 'NUMBER_PACK_YEARS_SMOKED'.
-
DNAH10 mutation correlated to 'PATHOLOGIC_STAGE'.
-
RIC3 mutation correlated to 'YEARS_TO_BIRTH'.
-
IVL mutation correlated to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.
-
LRRC32 mutation correlated to 'RESIDUAL_TUMOR'.
Clinical Features |
Time to Death |
YEARS TO BIRTH |
PATHOLOGIC STAGE |
PATHOLOGY T STAGE |
PATHOLOGY N STAGE |
PATHOLOGY M STAGE |
GENDER |
RADIATION THERAPY |
KARNOFSKY PERFORMANCE SCORE |
HISTOLOGICAL TYPE |
NUMBER PACK YEARS SMOKED |
RESIDUAL TUMOR |
NUMBER OF LYMPH NODES |
RACE | ETHNICITY | ||
nMutated (%) | nWild-Type | logrank test | Wilcoxon-test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Wilcoxon-test | Fisher's exact test | Wilcoxon-test | Fisher's exact test | Wilcoxon-test | Fisher's exact test | Fisher's exact test | |
TP53 | 153 (83%) | 32 |
0.93 (1.00) |
0.000185 (0.0409) |
0.276 (1.00) |
0.424 (1.00) |
0.443 (1.00) |
1 (1.00) |
0.0946 (0.947) |
0.159 (1.00) |
0.126 (0.992) |
0.0035 (0.242) |
0.975 (1.00) |
0.365 (1.00) |
0.368 (1.00) |
0.00014 (0.0409) |
1 (1.00) |
NFE2L2 | 16 (9%) | 169 |
0.983 (1.00) |
0.0459 (0.774) |
0.189 (1.00) |
0.059 (0.826) |
0.498 (1.00) |
1 (1.00) |
1 (1.00) |
0.742 (1.00) |
0.581 (1.00) |
0.00035 (0.0525) |
0.137 (1.00) |
0.327 (1.00) |
0.245 (1.00) |
4e-05 (0.036) |
0.587 (1.00) |
KIAA2018 | 13 (7%) | 172 |
0.0136 (0.599) |
0.00196 (0.168) |
0.497 (1.00) |
0.795 (1.00) |
0.223 (1.00) |
0.448 (1.00) |
1 (1.00) |
0.733 (1.00) |
0.323 (1.00) |
0.152 (1.00) |
0.00206 (0.168) |
0.45 (1.00) |
0.943 (1.00) |
0.657 (1.00) |
0.334 (1.00) |
IVL | 15 (8%) | 170 |
0.138 (1.00) |
0.00175 (0.168) |
0.0601 (0.826) |
0.696 (1.00) |
0.186 (1.00) |
0.409 (1.00) |
0.463 (1.00) |
0.119 (0.974) |
0.000208 (0.0409) |
0.0153 (0.599) |
0.569 (1.00) |
0.574 (1.00) |
0.0428 (0.74) |
0.0314 (0.669) |
|
ERBB2 | 11 (6%) | 174 |
0.222 (1.00) |
0.283 (1.00) |
0.685 (1.00) |
1 (1.00) |
0.391 (1.00) |
1 (1.00) |
0.664 (1.00) |
0.113 (0.964) |
0.000227 (0.0409) |
0.796 (1.00) |
1 (1.00) |
0.525 (1.00) |
0.107 (0.947) |
0.286 (1.00) |
|
DNAH10 | 19 (10%) | 166 |
0.241 (1.00) |
0.291 (1.00) |
0.00162 (0.168) |
0.395 (1.00) |
0.567 (1.00) |
0.598 (1.00) |
1 (1.00) |
1 (1.00) |
0.226 (1.00) |
0.226 (1.00) |
0.887 (1.00) |
0.101 (0.947) |
0.191 (1.00) |
1 (1.00) |
|
RIC3 | 4 (2%) | 181 |
0.359 (1.00) |
0.00288 (0.216) |
0.213 (1.00) |
0.836 (1.00) |
0.329 (1.00) |
1 (1.00) |
0.471 (1.00) |
1 (1.00) |
0.353 (1.00) |
0.0317 (0.669) |
0.237 (1.00) |
0.595 (1.00) |
0.628 (1.00) |
||
LRRC32 | 9 (5%) | 176 |
0.0946 (0.947) |
0.146 (1.00) |
0.935 (1.00) |
0.372 (1.00) |
0.817 (1.00) |
1 (1.00) |
0.361 (1.00) |
0.681 (1.00) |
0.74 (1.00) |
0.238 (1.00) |
0.00074 (0.0951) |
0.136 (1.00) |
0.739 (1.00) |
1 (1.00) |
|
SMAD4 | 13 (7%) | 172 |
0.389 (1.00) |
0.946 (1.00) |
0.159 (1.00) |
0.605 (1.00) |
0.0387 (0.74) |
1 (1.00) |
0.696 (1.00) |
0.731 (1.00) |
0.0426 (0.74) |
0.716 (1.00) |
0.149 (1.00) |
0.124 (0.989) |
0.42 (1.00) |
1 (1.00) |
|
CDKN2A | 19 (10%) | 166 |
0.342 (1.00) |
0.559 (1.00) |
0.225 (1.00) |
1 (1.00) |
0.065 (0.826) |
0.6 (1.00) |
0.489 (1.00) |
0.032 (0.669) |
0.836 (1.00) |
0.0274 (0.669) |
0.518 (1.00) |
0.624 (1.00) |
0.283 (1.00) |
0.365 (1.00) |
0.38 (1.00) |
MLL2 | 32 (17%) | 153 |
0.692 (1.00) |
0.738 (1.00) |
0.27 (1.00) |
0.515 (1.00) |
0.585 (1.00) |
0.685 (1.00) |
0.0946 (0.947) |
0.0645 (0.826) |
0.115 (0.967) |
0.119 (0.974) |
0.234 (1.00) |
0.468 (1.00) |
0.818 (1.00) |
0.0182 (0.602) |
1 (1.00) |
ZNF750 | 10 (5%) | 175 |
0.849 (1.00) |
0.727 (1.00) |
0.546 (1.00) |
0.35 (1.00) |
0.306 (1.00) |
1 (1.00) |
1 (1.00) |
0.238 (1.00) |
0.0869 (0.938) |
0.0191 (0.602) |
0.582 (1.00) |
0.57 (1.00) |
0.905 (1.00) |
0.0173 (0.599) |
1 (1.00) |
TGFBR2 | 15 (8%) | 170 |
0.57 (1.00) |
0.183 (1.00) |
0.188 (1.00) |
0.887 (1.00) |
0.081 (0.9) |
0.519 (1.00) |
0.241 (1.00) |
1 (1.00) |
0.356 (1.00) |
0.596 (1.00) |
0.128 (1.00) |
0.847 (1.00) |
0.428 (1.00) |
0.842 (1.00) |
1 (1.00) |
FBXW7 | 13 (7%) | 172 |
0.253 (1.00) |
0.303 (1.00) |
0.622 (1.00) |
0.567 (1.00) |
0.089 (0.942) |
0.448 (1.00) |
0.102 (0.947) |
0.518 (1.00) |
0.061 (0.826) |
0.152 (1.00) |
0.557 (1.00) |
0.78 (1.00) |
0.284 (1.00) |
0.424 (1.00) |
0.0621 (0.826) |
PKD2 | 7 (4%) | 178 |
0.389 (1.00) |
0.166 (1.00) |
0.982 (1.00) |
0.602 (1.00) |
0.779 (1.00) |
1 (1.00) |
0.596 (1.00) |
0.0388 (0.74) |
0.0732 (0.834) |
0.446 (1.00) |
0.984 (1.00) |
1 (1.00) |
0.933 (1.00) |
0.282 (1.00) |
1 (1.00) |
ARID1A | 15 (8%) | 170 |
0.874 (1.00) |
0.0612 (0.826) |
0.575 (1.00) |
0.55 (1.00) |
0.211 (1.00) |
1 (1.00) |
0.0482 (0.774) |
0.0225 (0.642) |
0.0136 (0.599) |
0.709 (1.00) |
0.371 (1.00) |
0.284 (1.00) |
0.175 (1.00) |
0.181 (1.00) |
|
PTCH1 | 12 (6%) | 173 |
0.393 (1.00) |
0.639 (1.00) |
0.66 (1.00) |
0.792 (1.00) |
0.335 (1.00) |
0.448 (1.00) |
1 (1.00) |
0.476 (1.00) |
0.288 (1.00) |
0.136 (1.00) |
0.589 (1.00) |
0.496 (1.00) |
0.843 (1.00) |
0.0652 (0.826) |
0.235 (1.00) |
FAM108A1 | 4 (2%) | 181 |
0.0693 (0.832) |
0.748 (1.00) |
0.877 (1.00) |
0.58 (1.00) |
1 (1.00) |
1 (1.00) |
0.102 (0.947) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.545 (1.00) |
1 (1.00) |
1 (1.00) |
||
PAXIP1 | 10 (5%) | 175 |
0.552 (1.00) |
0.192 (1.00) |
0.296 (1.00) |
0.136 (1.00) |
0.747 (1.00) |
0.0984 (0.947) |
0.642 (1.00) |
0.696 (1.00) |
0.853 (1.00) |
0.749 (1.00) |
0.251 (1.00) |
1 (1.00) |
0.511 (1.00) |
0.785 (1.00) |
1 (1.00) |
MGC29506 | 4 (2%) | 181 |
0.244 (1.00) |
0.671 (1.00) |
0.281 (1.00) |
0.686 (1.00) |
0.4 (1.00) |
0.228 (1.00) |
0.471 (1.00) |
0.573 (1.00) |
1 (1.00) |
1 (1.00) |
0.287 (1.00) |
0.268 (1.00) |
|||
C10ORF76 | 6 (3%) | 179 |
0.397 (1.00) |
0.52 (1.00) |
0.257 (1.00) |
0.262 (1.00) |
0.166 (1.00) |
1 (1.00) |
0.0413 (0.74) |
1 (1.00) |
0.684 (1.00) |
0.472 (1.00) |
0.592 (1.00) |
0.756 (1.00) |
0.732 (1.00) |
1 (1.00) |
|
IPP | 6 (3%) | 179 |
0.49 (1.00) |
0.00907 (0.544) |
0.777 (1.00) |
0.29 (1.00) |
0.302 (1.00) |
1 (1.00) |
1 (1.00) |
0.34 (1.00) |
0.43 (1.00) |
0.489 (1.00) |
1 (1.00) |
0.603 (1.00) |
0.629 (1.00) |
1 (1.00) |
|
HMMR | 4 (2%) | 181 |
0.651 (1.00) |
0.428 (1.00) |
0.536 (1.00) |
0.689 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.454 (1.00) |
0.409 (1.00) |
1 (1.00) |
1 (1.00) |
||
PIAS1 | 5 (3%) | 180 |
0.665 (1.00) |
0.879 (1.00) |
0.292 (1.00) |
0.209 (1.00) |
0.365 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.673 (1.00) |
0.364 (1.00) |
1 (1.00) |
0.82 (1.00) |
0.629 (1.00) |
1 (1.00) |
|
ITGA6 | 7 (4%) | 178 |
0.529 (1.00) |
0.0409 (0.74) |
0.852 (1.00) |
0.548 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.0388 (0.74) |
0.0385 (0.74) |
1 (1.00) |
0.396 (1.00) |
0.288 (1.00) |
0.4 (1.00) |
0.465 (1.00) |
1 (1.00) |
ASTE1 | 5 (3%) | 180 |
0.299 (1.00) |
0.0167 (0.599) |
0.209 (1.00) |
0.416 (1.00) |
0.148 (1.00) |
1 (1.00) |
0.155 (1.00) |
0.573 (1.00) |
0.0243 (0.643) |
0.511 (1.00) |
0.299 (1.00) |
0.256 (1.00) |
0.628 (1.00) |
1 (1.00) |
|
KPNA1 | 6 (3%) | 179 |
0.4 (1.00) |
0.898 (1.00) |
0.591 (1.00) |
0.499 (1.00) |
0.391 (1.00) |
1 (1.00) |
0.595 (1.00) |
0.648 (1.00) |
0.43 (1.00) |
0.844 (1.00) |
0.598 (1.00) |
0.857 (1.00) |
1 (1.00) |
1 (1.00) |
|
LIMA1 | 8 (4%) | 177 |
0.639 (1.00) |
0.107 (0.947) |
0.0875 (0.938) |
0.0468 (0.774) |
1 (1.00) |
0.409 (1.00) |
0.0941 (0.947) |
0.681 (1.00) |
0.157 (1.00) |
0.843 (1.00) |
1 (1.00) |
0.368 (1.00) |
0.568 (1.00) |
1 (1.00) |
|
FAM65B | 8 (4%) | 177 |
0.513 (1.00) |
0.326 (1.00) |
0.668 (1.00) |
0.596 (1.00) |
0.903 (1.00) |
0.368 (1.00) |
1 (1.00) |
0.192 (1.00) |
0.722 (1.00) |
0.61 (1.00) |
1 (1.00) |
0.633 (1.00) |
1 (1.00) |
1 (1.00) |
|
CORO7 | 7 (4%) | 178 |
0.0714 (0.834) |
0.382 (1.00) |
0.623 (1.00) |
0.358 (1.00) |
0.562 (1.00) |
1 (1.00) |
0.271 (1.00) |
0.329 (1.00) |
0.264 (1.00) |
0.316 (1.00) |
0.0296 (0.669) |
0.768 (1.00) |
0.321 (1.00) |
1 (1.00) |
|
ANAPC1 | 5 (3%) | 180 |
0.203 (1.00) |
0.226 (1.00) |
0.438 (1.00) |
1 (1.00) |
0.366 (1.00) |
1 (1.00) |
0.0229 (0.642) |
0.329 (1.00) |
0.673 (1.00) |
1 (1.00) |
0.558 (1.00) |
1 (1.00) |
1 (1.00) |
||
PIK3CA | 19 (10%) | 166 |
0.672 (1.00) |
0.0205 (0.615) |
0.953 (1.00) |
0.0718 (0.834) |
0.822 (1.00) |
1 (1.00) |
0.744 (1.00) |
0.771 (1.00) |
0.415 (1.00) |
0.151 (1.00) |
0.152 (1.00) |
0.875 (1.00) |
0.498 (1.00) |
0.593 (1.00) |
0.57 (1.00) |
RB1 | 7 (4%) | 178 |
0.0669 (0.83) |
0.695 (1.00) |
0.515 (1.00) |
0.37 (1.00) |
0.334 (1.00) |
1 (1.00) |
0.271 (1.00) |
0.192 (1.00) |
0.458 (1.00) |
1 (1.00) |
0.289 (1.00) |
1 (1.00) |
0.911 (1.00) |
1 (1.00) |
1 (1.00) |
EIF4EBP2 | 3 (2%) | 182 |
0.677 (1.00) |
0.119 (0.974) |
1 (1.00) |
1 (1.00) |
0.57 (1.00) |
0.109 (0.947) |
0.596 (1.00) |
1 (1.00) |
|||||||
SCD | 3 (2%) | 182 |
0.993 (1.00) |
0.105 (0.947) |
0.153 (1.00) |
0.474 (1.00) |
0.0291 (0.669) |
1 (1.00) |
0.379 (1.00) |
1 (1.00) |
0.609 (1.00) |
1 (1.00) |
0.0159 (0.599) |
1 (1.00) |
|||
MKL2 | 6 (3%) | 179 |
0.675 (1.00) |
0.0146 (0.599) |
0.305 (1.00) |
1 (1.00) |
0.365 (1.00) |
1 (1.00) |
1 (1.00) |
0.329 (1.00) |
0.107 (0.947) |
0.0301 (0.669) |
0.302 (1.00) |
0.558 (1.00) |
0.325 (1.00) |
1 (1.00) |
|
NOTCH1 | 18 (10%) | 167 |
0.924 (1.00) |
0.311 (1.00) |
0.465 (1.00) |
0.35 (1.00) |
0.627 (1.00) |
0.6 (1.00) |
1 (1.00) |
0.365 (1.00) |
0.893 (1.00) |
0.0252 (0.648) |
0.367 (1.00) |
0.537 (1.00) |
0.244 (1.00) |
0.0758 (0.853) |
0.57 (1.00) |
KLF3 | 3 (2%) | 182 |
0.66 (1.00) |
0.0128 (0.599) |
0.422 (1.00) |
1 (1.00) |
0.0649 (0.826) |
1 (1.00) |
0.379 (1.00) |
0.57 (1.00) |
0.109 (0.947) |
1 (1.00) |
0.54 (1.00) |
0.598 (1.00) |
|||
IL10RA | 3 (2%) | 182 |
0.952 (1.00) |
0.849 (1.00) |
0.466 (1.00) |
0.629 (1.00) |
0.727 (1.00) |
1 (1.00) |
1 (1.00) |
0.163 (1.00) |
0.609 (1.00) |
1 (1.00) |
0.719 (1.00) |
0.596 (1.00) |
1 (1.00) |
||
RAD17 | 4 (2%) | 181 |
0.186 (1.00) |
0.962 (1.00) |
0.552 (1.00) |
1 (1.00) |
0.611 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.926 (1.00) |
0.622 (1.00) |
0.861 (1.00) |
0.24 (1.00) |
0.624 (1.00) |
1 (1.00) |
1 (1.00) |
KPNB1 | 6 (3%) | 179 |
0.541 (1.00) |
0.0838 (0.919) |
0.945 (1.00) |
0.695 (1.00) |
0.639 (1.00) |
1 (1.00) |
0.595 (1.00) |
0.648 (1.00) |
0.164 (1.00) |
0.213 (1.00) |
0.808 (1.00) |
0.596 (1.00) |
0.4 (1.00) |
0.111 (0.949) |
1 (1.00) |
ZBED4 | 5 (3%) | 180 |
0.7 (1.00) |
0.909 (1.00) |
1 (1.00) |
0.754 (1.00) |
0.672 (1.00) |
1 (1.00) |
1 (1.00) |
0.273 (1.00) |
0.164 (1.00) |
0.37 (1.00) |
0.935 (1.00) |
0.302 (1.00) |
0.269 (1.00) |
1 (1.00) |
|
NAA16 | 6 (3%) | 179 |
0.777 (1.00) |
0.941 (1.00) |
0.287 (1.00) |
0.0482 (0.774) |
0.0566 (0.826) |
1 (1.00) |
0.595 (1.00) |
0.648 (1.00) |
0.43 (1.00) |
0.733 (1.00) |
0.23 (1.00) |
0.269 (1.00) |
1 (1.00) |
1 (1.00) |
|
CNNM2 | 7 (4%) | 178 |
0.26 (1.00) |
0.0648 (0.826) |
0.634 (1.00) |
0.341 (1.00) |
0.369 (1.00) |
0.324 (1.00) |
1 (1.00) |
0.679 (1.00) |
0.264 (1.00) |
0.0235 (0.642) |
1 (1.00) |
0.25 (1.00) |
0.736 (1.00) |
1 (1.00) |
|
HLA-B | 7 (4%) | 178 |
0.232 (1.00) |
0.871 (1.00) |
0.188 (1.00) |
1 (1.00) |
0.641 (1.00) |
1 (1.00) |
0.271 (1.00) |
0.329 (1.00) |
1 (1.00) |
0.265 (1.00) |
1 (1.00) |
0.861 (1.00) |
0.352 (1.00) |
1 (1.00) |
|
PLXNB2 | 12 (6%) | 173 |
0.689 (1.00) |
0.641 (1.00) |
0.491 (1.00) |
0.531 (1.00) |
0.319 (1.00) |
1 (1.00) |
1 (1.00) |
0.476 (1.00) |
0.299 (1.00) |
1 (1.00) |
0.658 (1.00) |
1 (1.00) |
0.558 (1.00) |
0.505 (1.00) |
0.463 (1.00) |
PTEN | 7 (4%) | 178 |
0.371 (1.00) |
0.392 (1.00) |
0.765 (1.00) |
0.243 (1.00) |
0.705 (1.00) |
1 (1.00) |
0.271 (1.00) |
0.679 (1.00) |
0.535 (1.00) |
0.446 (1.00) |
0.984 (1.00) |
1 (1.00) |
0.891 (1.00) |
0.528 (1.00) |
1 (1.00) |
CPT1B | 5 (3%) | 180 |
0.413 (1.00) |
0.973 (1.00) |
0.748 (1.00) |
0.36 (1.00) |
0.145 (1.00) |
1 (1.00) |
0.55 (1.00) |
1 (1.00) |
1 (1.00) |
0.596 (1.00) |
1 (1.00) |
0.131 (1.00) |
0.166 (1.00) |
0.124 (0.989) |
|
CAMTA1 | 9 (5%) | 176 |
0.816 (1.00) |
0.153 (1.00) |
0.345 (1.00) |
0.861 (1.00) |
0.141 (1.00) |
1 (1.00) |
0.622 (1.00) |
1 (1.00) |
0.316 (1.00) |
0.378 (1.00) |
0.396 (1.00) |
0.664 (1.00) |
0.738 (1.00) |
1 (1.00) |
|
OTUD7B | 7 (4%) | 178 |
0.392 (1.00) |
0.326 (1.00) |
0.617 (1.00) |
0.289 (1.00) |
0.494 (1.00) |
1 (1.00) |
0.0652 (0.826) |
0.648 (1.00) |
0.712 (1.00) |
0.314 (1.00) |
0.599 (1.00) |
0.805 (1.00) |
0.0682 (0.83) |
1 (1.00) |
|
ARRB1 | 5 (3%) | 180 |
0.759 (1.00) |
0.976 (1.00) |
0.642 (1.00) |
0.578 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.673 (1.00) |
0.337 (1.00) |
0.452 (1.00) |
0.783 (1.00) |
1 (1.00) |
1 (1.00) |
|
KIAA1704 | 3 (2%) | 182 |
0.231 (1.00) |
0.147 (1.00) |
0.19 (1.00) |
1 (1.00) |
0.0286 (0.669) |
1 (1.00) |
0.379 (1.00) |
0.57 (1.00) |
0.609 (1.00) |
1 (1.00) |
0.188 (1.00) |
1 (1.00) |
|||
RNF169 | 6 (3%) | 179 |
0.724 (1.00) |
0.753 (1.00) |
0.679 (1.00) |
0.561 (1.00) |
1 (1.00) |
0.278 (1.00) |
0.595 (1.00) |
0.108 (0.947) |
0.0732 (0.834) |
0.43 (1.00) |
0.679 (1.00) |
1 (1.00) |
0.519 (1.00) |
1 (1.00) |
1 (1.00) |
RBPJL | 6 (3%) | 179 |
0.165 (1.00) |
0.16 (1.00) |
1 (1.00) |
0.448 (1.00) |
0.855 (1.00) |
1 (1.00) |
0.212 (1.00) |
0.108 (0.947) |
0.684 (1.00) |
0.369 (1.00) |
0.359 (1.00) |
0.563 (1.00) |
1 (1.00) |
1 (1.00) |
|
MGAT5B | 8 (4%) | 177 |
0.0533 (0.826) |
0.468 (1.00) |
0.189 (1.00) |
0.341 (1.00) |
0.016 (0.599) |
0.278 (1.00) |
1 (1.00) |
1 (1.00) |
0.362 (1.00) |
1 (1.00) |
0.605 (1.00) |
0.414 (1.00) |
0.336 (1.00) |
0.739 (1.00) |
0.0194 (0.602) |
TCHH | 14 (8%) | 171 |
0.24 (1.00) |
0.954 (1.00) |
0.952 (1.00) |
0.124 (0.989) |
0.866 (1.00) |
1 (1.00) |
1 (1.00) |
0.0501 (0.791) |
0.602 (1.00) |
0.784 (1.00) |
0.82 (1.00) |
1 (1.00) |
0.521 (1.00) |
0.0675 (0.83) |
1 (1.00) |
SLC22A2 | 4 (2%) | 181 |
0.85 (1.00) |
0.0984 (0.947) |
0.363 (1.00) |
0.26 (1.00) |
0.477 (1.00) |
0.228 (1.00) |
0.471 (1.00) |
0.163 (1.00) |
0.353 (1.00) |
1 (1.00) |
0.302 (1.00) |
0.405 (1.00) |
1 (1.00) |
||
PCDH15 | 21 (11%) | 164 |
0.769 (1.00) |
0.509 (1.00) |
0.0985 (0.947) |
0.572 (1.00) |
0.0143 (0.599) |
1 (1.00) |
0.321 (1.00) |
1 (1.00) |
0.591 (1.00) |
0.246 (1.00) |
0.221 (1.00) |
0.484 (1.00) |
0.0122 (0.599) |
0.324 (1.00) |
0.536 (1.00) |
KIAA1549 | 8 (4%) | 177 |
0.733 (1.00) |
0.168 (1.00) |
0.749 (1.00) |
0.0607 (0.826) |
0.409 (1.00) |
1 (1.00) |
0.33 (1.00) |
0.679 (1.00) |
1 (1.00) |
0.187 (1.00) |
1 (1.00) |
0.834 (1.00) |
0.565 (1.00) |
0.181 (1.00) |
|
SETBP1 | 14 (8%) | 171 |
0.3 (1.00) |
0.00572 (0.368) |
0.615 (1.00) |
0.291 (1.00) |
0.868 (1.00) |
0.581 (1.00) |
1 (1.00) |
1 (1.00) |
0.557 (1.00) |
0.0949 (0.947) |
0.211 (1.00) |
0.429 (1.00) |
0.536 (1.00) |
0.0415 (0.74) |
0.334 (1.00) |
P value = 0.000185 (Wilcoxon-test), Q value = 0.041
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 185 | 62.5 (11.9) |
TP53 MUTATED | 153 | 60.9 (11.6) |
TP53 WILD-TYPE | 32 | 69.8 (10.7) |
P value = 0.0035 (Fisher's exact test), Q value = 0.24
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 89 | 96 |
TP53 MUTATED | 66 | 87 |
TP53 WILD-TYPE | 23 | 9 |
P value = 0.00014 (Fisher's exact test), Q value = 0.041
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 46 | 5 | 114 |
TP53 MUTATED | 46 | 4 | 87 |
TP53 WILD-TYPE | 0 | 1 | 27 |
P value = 0.00035 (Fisher's exact test), Q value = 0.052
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 89 | 96 |
NFE2L2 MUTATED | 1 | 15 |
NFE2L2 WILD-TYPE | 88 | 81 |
P value = 4e-05 (Fisher's exact test), Q value = 0.036
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 46 | 5 | 114 |
NFE2L2 MUTATED | 12 | 0 | 3 |
NFE2L2 WILD-TYPE | 34 | 5 | 111 |
P value = 0.000227 (Fisher's exact test), Q value = 0.041
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 89 | 96 |
ERBB2 MUTATED | 11 | 0 |
ERBB2 WILD-TYPE | 78 | 96 |
P value = 0.00196 (Wilcoxon-test), Q value = 0.17
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 185 | 62.5 (11.9) |
KIAA2018 MUTATED | 13 | 72.7 (10.0) |
KIAA2018 WILD-TYPE | 172 | 61.7 (11.7) |
P value = 0.00206 (Wilcoxon-test), Q value = 0.17
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 98 | 34.5 (21.5) |
KIAA2018 MUTATED | 7 | 56.9 (12.7) |
KIAA2018 WILD-TYPE | 91 | 32.8 (21.1) |
P value = 0.00162 (Fisher's exact test), Q value = 0.17
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 8 | 5 | 6 | 1 | 47 | 31 | 26 | 14 | 9 | 7 | 5 | 4 |
DNAH10 MUTATED | 3 | 0 | 1 | 0 | 1 | 11 | 1 | 1 | 0 | 1 | 0 | 0 |
DNAH10 WILD-TYPE | 5 | 5 | 5 | 1 | 46 | 20 | 25 | 13 | 9 | 6 | 5 | 4 |
P value = 0.00288 (Wilcoxon-test), Q value = 0.22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 185 | 62.5 (11.9) |
RIC3 MUTATED | 4 | 82.2 (6.1) |
RIC3 WILD-TYPE | 181 | 62.0 (11.6) |
P value = 0.00175 (Wilcoxon-test), Q value = 0.17
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 185 | 62.5 (11.9) |
IVL MUTATED | 15 | 71.8 (10.0) |
IVL WILD-TYPE | 170 | 61.6 (11.7) |
P value = 0.000208 (Fisher's exact test), Q value = 0.041
nPatients | ESOPHAGUS ADENOCARCINOMA, NOS | ESOPHAGUS SQUAMOUS CELL CARCINOMA |
---|---|---|
ALL | 89 | 96 |
IVL MUTATED | 14 | 1 |
IVL WILD-TYPE | 75 | 95 |
P value = 0.00074 (Fisher's exact test), Q value = 0.095
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 137 | 13 | 2 | 7 |
LRRC32 MUTATED | 3 | 2 | 0 | 3 |
LRRC32 WILD-TYPE | 134 | 11 | 2 | 4 |
-
Mutation data file = sample_sig_gene_table.txt from Mutsig_2CV pipeline
-
Processed Mutation data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/ESCA-TP/22588509/transformed.cor.cli.txt
-
Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/ESCA-TP/22506419/ESCA-TP.merged_data.txt
-
Number of patients = 185
-
Number of significantly mutated genes = 60
-
Number of selected clinical features = 15
-
Exclude genes that fewer than K tumors have mutations, K = 3
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.