HotNet pathway analysis of mutation and copy number data
Lung Adenocarcinoma (Primary solid tumor)
22 February 2013  |  analyses__2013_02_22
Maintainer Information
Citation Information
Maintained by Hailei Zhang (Broad Institute)
Cite as Broad Institute TCGA Genome Data Analysis Center (2013): HotNet pathway analysis of mutation and copy number data. Broad Institute of MIT and Harvard. doi:10.7908/C19G5K12
- Overview
+ Introduction
- Summary

There were 87 significant subnetworks identified in HotNet analysis.

- Results
- Significant subnetworks

HotNet identifies 87 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.

Table 1.  Get Full Table Top 10 out of 87 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.

Network No.ofgenes p-value RepeatTimes
CLU(41),C9(102),C7(106) 3 0 3
CSF1R(4),GAB3(65),CSF1(107) 3 0 3
GSTM1(107),GSTM2(108),GSTM3(107) 3 0 3
HESX1(1),PITX2(3),PROP1(43) 3 0 3
NMUR2(7),NMUR1(4),NMU(33) 3 0 3
NPC2(84),LOX(1),DHDDS(100) 3 0 3
NPFFR2(10),NPY(102),MC4R(87) 3 0 3
PHF17(5),UBE3A(98),UBE2D3(3) 3 0 3
PMS2(103),MLH3(84),MLH1(4) 3 0 3
SAP18(56),TADA3(1),USP5(63) 3 0 3
+ Methods & Data