Head and Neck Squamous Cell Carcinoma: PARADIGM pathway analysis of mRNASeq expression data
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Overview
Introduction

PAthway Representation and Analysis by Direct Inference on Graphical Models (PARADIGM) predicts the activity of a diverse set of molecular concepts such as genes, complexes, and processes. The predicted activities are called Inferred Pathway Levels (IPLs) and are derived from a probabilistic belief propagation strategy that incorporates multimodal data such as copy number and gene expression estimates with a concept's pathway context.

Summary

There were 37 significant pathways identified in this analysis.

Table 1.  Get Full Table Top 10 out of 131 pathways in order of significance.

Pathway.Name Avg.Num.Perturbations
TCGA08_retinoblastoma 103
IL23-mediated signaling events 54
IL4-mediated signaling events 43
TCGA08_p53 42
TCR signaling in naïve CD8+ T cells 34
Signaling mediated by p38-alpha and p38-beta 33
IL12-mediated signaling events 31
p75(NTR)-mediated signaling 30
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 28
HIF-1-alpha transcription factor network 27
Results
Summary Table

The following list describes the columns found in Table 2.

  • Pathway.Name = Full pathway name of curated PARADIGM pathway

  • Avg.Num.Perturbations = Average number of samples with perturbations across the pathway concepts determined by a background permutation model (>2 standard deviations away from the permuted distribution)

  • Total.Perturbations = Total number of perturbed concepts across all samples (>2 standard deviations away from the permuted distribution)

  • Num.Entities = Number of concepts that belong to the pathway

  • Min.Mean.Truth = Minimum IPL for concepts in the pathway among real samples

  • Max.Mean.Truth = Maximum IPL for concepts in the pathway among real samples

  • Min.Mean.Within = Minimum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Max.Mean.Within = Maximum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Min.Mean.Any = Minimum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes)

  • Max.Mean.Any = Maximum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes).

Table 2.  Get Full Table This summary table provides a report of cancer type specific pathway perturbations. Click on the links in the first column to display more detailed results for each pathway.

Pathway.Name Avg.Num.Perturbations Total.Perturbations Num.Entities Min.Mean.Truth Max.Mean.Truth Min.Mean.Within Max.Mean.Within Min.Mean.Any Max.Mean.Within.1
TCGA08_retinoblastoma 103 827 8 -0.29 0.17 1000 -1000 -0.023 -1000
IL23-mediated signaling events 54 3268 60 -0.77 0.013 1000 -1000 -0.22 -1000
IL4-mediated signaling events 43 3994 91 -0.84 0.7 1000 -1000 -0.19 -1000
TCGA08_p53 42 295 7 -0.23 0.13 1000 -1000 -0.025 -1000
TCR signaling in naïve CD8+ T cells 34 3173 93 -0.21 0.11 1000 -1000 -0.11 -1000
Signaling mediated by p38-alpha and p38-beta 33 1485 44 -0.29 0.013 1000 -1000 -0.061 -1000
IL12-mediated signaling events 31 2759 87 -0.37 0.12 1000 -1000 -0.16 -1000
p75(NTR)-mediated signaling 30 3765 125 -0.28 0.019 1000 -1000 -0.13 -1000
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 28 1928 68 -0.42 0.11 1000 -1000 -0.17 -1000
HIF-1-alpha transcription factor network 27 2086 76 -0.44 0.02 1000 -1000 -0.24 -1000
Effects of Botulinum toxin 27 719 26 -0.3 0.013 1000 -1000 -0.087 -1000
Glypican 2 network 27 110 4 -0.048 -0.045 1000 -1000 -0.026 -1000
Wnt signaling 27 194 7 -0.13 0.013 1000 -1000 -0.045 -1000
amb2 Integrin signaling 26 2147 82 -0.32 0.013 1000 -1000 -0.11 -1000
Calcium signaling in the CD4+ TCR pathway 25 784 31 -0.33 0.013 1000 -1000 -0.11 -1000
BCR signaling pathway 25 2511 99 -0.27 0.014 1000 -1000 -0.12 -1000
Syndecan-1-mediated signaling events 23 808 34 -0.17 0.013 1000 -1000 -0.083 -1000
Syndecan-2-mediated signaling events 23 1617 69 -0.18 0.018 1000 -1000 -0.067 -1000
BMP receptor signaling 23 1864 81 -0.25 0.039 1000 -1000 -0.12 -1000
Signaling events regulated by Ret tyrosine kinase 23 1922 82 -0.19 0.013 1000 -1000 -0.11 -1000
Neurotrophic factor-mediated Trk receptor signaling 22 2704 120 -0.32 0.19 1000 -1000 -0.093 -1000
Visual signal transduction: Rods 22 1167 52 -0.25 0.013 1000 -1000 -0.092 -1000
Glypican 1 network 21 1039 48 -0.26 0.022 1000 -1000 -0.063 -1000
Signaling events mediated by the Hedgehog family 20 1085 52 -0.14 0.1 1000 -1000 -0.1 -1000
Noncanonical Wnt signaling pathway 20 526 26 -0.16 0.013 1000 -1000 -0.084 -1000
FOXA2 and FOXA3 transcription factor networks 20 949 46 -0.3 0.02 1000 -1000 -0.12 -1000
Syndecan-4-mediated signaling events 20 1348 67 -0.18 0.018 1000 -1000 -0.094 -1000
Class IB PI3K non-lipid kinase events 20 60 3 -0.034 -1000 1000 -1000 -0.02 -1000
LPA4-mediated signaling events 19 228 12 -0.12 0.019 1000 -1000 -0.037 -1000
Glucocorticoid receptor regulatory network 19 2271 114 -0.37 0.26 1000 -1000 -0.084 -1000
Endothelins 19 1887 96 -0.2 0.032 1000 -1000 -0.11 -1000
PDGFR-alpha signaling pathway 18 832 44 -0.2 0.022 1000 -1000 -0.076 -1000
Coregulation of Androgen receptor activity 17 1294 76 -0.42 0.029 1000 -1000 -0.062 -1000
Ephrin A reverse signaling 16 117 7 -0.032 0 1000 -1000 -0.036 -1000
Thromboxane A2 receptor signaling 16 1730 105 -0.14 0.029 1000 -1000 -0.087 -1000
EGFR-dependent Endothelin signaling events 16 355 21 -0.14 0.019 1000 -1000 -0.086 -1000
Signaling events mediated by Stem cell factor receptor (c-Kit) 16 1265 78 -0.099 0.047 1000 -1000 -0.097 -1000
Caspase cascade in apoptosis 15 1129 74 -0.13 0.045 1000 -1000 -0.056 -1000
Visual signal transduction: Cones 15 593 38 -0.084 0.013 1000 -1000 -0.06 -1000
JNK signaling in the CD4+ TCR pathway 15 261 17 -0.087 0.013 1000 -1000 -0.096 -1000
a4b1 and a4b7 Integrin signaling 15 75 5 -0.034 -0.004 1000 -1000 -0.025 -1000
Signaling events mediated by PTP1B 14 1100 76 -0.18 0.019 1000 -1000 -0.1 -1000
Fc-epsilon receptor I signaling in mast cells 14 1446 97 -0.16 0.031 1000 -1000 -0.12 -1000
IL27-mediated signaling events 14 740 51 -0.16 0.056 1000 -1000 -0.096 -1000
Angiopoietin receptor Tie2-mediated signaling 14 1312 88 -0.14 0.03 1000 -1000 -0.14 -1000
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 14 479 33 -0.3 0.033 1000 -1000 -0.086 -1000
Nephrin/Neph1 signaling in the kidney podocyte 13 442 34 -0.063 0.013 1000 -1000 -0.071 -1000
Osteopontin-mediated events 13 500 38 -0.15 0.013 1000 -1000 -0.13 -1000
Arf6 signaling events 13 862 62 -0.14 0.027 1000 -1000 -0.085 -1000
Integrins in angiogenesis 13 1160 84 -0.16 0.017 1000 -1000 -0.12 -1000
Reelin signaling pathway 12 697 56 -0.18 0.017 1000 -1000 -0.11 -1000
FAS signaling pathway (CD95) 12 609 47 -0.15 0.03 1000 -1000 -0.065 -1000
Syndecan-3-mediated signaling events 12 450 35 -0.17 0.013 1000 -1000 -0.094 -1000
Nongenotropic Androgen signaling 12 634 52 -0.11 0.013 1000 -1000 -0.084 -1000
Ras signaling in the CD4+ TCR pathway 12 210 17 -0.049 0.024 1000 -1000 -0.068 -1000
ErbB4 signaling events 11 785 69 -0.28 0.063 1000 -1000 -0.12 -1000
Paxillin-independent events mediated by a4b1 and a4b7 11 429 37 -0.1 0.017 1000 -1000 -0.071 -1000
EPHB forward signaling 11 1014 85 -0.16 0.095 1000 -1000 -0.12 -1000
Plasma membrane estrogen receptor signaling 11 999 86 -0.082 0.032 1000 -1000 -0.11 -1000
Regulation of nuclear SMAD2/3 signaling 10 1384 136 -0.29 0.17 1000 -1000 -0.1 -1000
Cellular roles of Anthrax toxin 10 404 39 -0.08 0.015 1000 -1000 -0.039 -1000
Presenilin action in Notch and Wnt signaling 10 633 61 -0.18 0.029 1000 -1000 -0.096 -1000
IL1-mediated signaling events 10 630 62 -0.16 0.061 1000 -1000 -0.12 -1000
RXR and RAR heterodimerization with other nuclear receptor 10 550 52 -0.1 0.022 1000 -1000 -0.065 -1000
Canonical Wnt signaling pathway 10 539 51 -0.18 0.053 1000 -1000 -0.086 -1000
LPA receptor mediated events 9 1002 102 -0.074 0.023 1000 -1000 -0.11 -1000
IL6-mediated signaling events 9 704 75 -0.16 0.054 1000 -1000 -0.11 -1000
Regulation of Androgen receptor activity 9 667 70 -0.42 0.028 1000 -1000 -0.098 -1000
Signaling events mediated by HDAC Class III 8 339 40 -0.11 0.085 1000 -1000 -0.061 -1000
TRAIL signaling pathway 8 413 48 -0.047 0.022 1000 -1000 -0.087 -1000
S1P1 pathway 8 302 36 -0.14 0.013 1000 -1000 -0.076 -1000
Ephrin B reverse signaling 7 354 48 -0.094 0.09 1000 -1000 -0.09 -1000
Signaling mediated by p38-gamma and p38-delta 7 113 15 -0.022 0.016 1000 -1000 -0.048 -1000
IL2 signaling events mediated by PI3K 7 459 58 -0.098 0.027 1000 -1000 -0.1 -1000
HIV-1 Nef: Negative effector of Fas and TNF-alpha 7 346 45 -0.15 0.017 1000 -1000 -0.12 -1000
IL2 signaling events mediated by STAT5 7 157 22 -0.033 0.028 1000 -1000 -0.064 -1000
Regulation of Telomerase 7 805 102 -0.14 0.044 1000 -1000 -0.12 -1000
FOXM1 transcription factor network 7 398 51 -0.31 0.18 1000 -1000 -0.22 -1000
ErbB2/ErbB3 signaling events 6 410 65 -0.2 0.024 1000 -1000 -0.086 -1000
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 6 556 85 -0.069 0.024 1000 -1000 -0.096 -1000
Hedgehog signaling events mediated by Gli proteins 6 402 65 -0.26 0.05 1000 -1000 -0.086 -1000
IFN-gamma pathway 6 470 68 -0.18 0.023 1000 -1000 -0.13 -1000
Paxillin-dependent events mediated by a4b1 6 231 36 -0.1 0.022 1000 -1000 -0.098 -1000
Regulation of p38-alpha and p38-beta 6 362 54 -0.18 0.031 1000 -1000 -0.092 -1000
IGF1 pathway 6 394 57 -0.079 0.019 1000 -1000 -0.12 -1000
PDGFR-beta signaling pathway 6 629 97 -0.11 0.044 1000 -1000 -0.11 -1000
Signaling events mediated by PRL 6 220 34 -0.13 0.038 1000 -1000 -0.051 -1000
Lissencephaly gene (LIS1) in neuronal migration and development 5 318 54 -0.12 0.026 1000 -1000 -0.13 -1000
Nectin adhesion pathway 5 369 63 -0.042 0.033 1000 -1000 -0.1 -1000
Ceramide signaling pathway 5 415 76 -0.14 0.035 1000 -1000 -0.075 -1000
Class I PI3K signaling events 5 420 73 -0.18 0.039 1000 -1000 -0.092 -1000
S1P3 pathway 5 218 42 -0.047 0.021 1000 -1000 -0.06 -1000
p38 MAPK signaling pathway 5 223 44 -0.14 0.025 1000 -1000 -0.087 -1000
EPO signaling pathway 4 254 55 -0.066 0.022 1000 -1000 -0.12 -1000
Retinoic acid receptors-mediated signaling 4 250 58 -0.06 0.015 1000 -1000 -0.096 -1000
Signaling events mediated by VEGFR1 and VEGFR2 4 623 125 -0.063 0.064 1000 -1000 -0.12 -1000
TCGA08_rtk_signaling 4 113 26 -0.048 0.039 1000 -1000 -0.029 -1000
Stabilization and expansion of the E-cadherin adherens junction 4 357 74 -0.14 0.064 1000 -1000 -0.12 -1000
Insulin Pathway 4 357 74 -0.12 0.033 1000 -1000 -0.11 -1000
Rapid glucocorticoid signaling 4 89 20 -0.033 0.013 1000 -1000 -0.054 -1000
S1P4 pathway 4 102 25 -0.048 0.019 1000 -1000 -0.072 -1000
Signaling events mediated by HDAC Class II 3 248 75 -0.081 0.032 1000 -1000 -0.088 -1000
Sphingosine 1-phosphate (S1P) pathway 3 106 28 -0.048 0.034 1000 -1000 -0.055 -1000
Circadian rhythm pathway 3 69 22 -0.052 0.047 1000 -1000 -0.053 -1000
Aurora A signaling 3 206 60 -0.077 0.034 1000 -1000 -0.077 -1000
S1P5 pathway 3 52 17 -0.048 0.02 1000 -1000 -0.065 -1000
ceramide signaling pathway 3 156 49 -0.061 0.031 1000 -1000 -0.071 -1000
HIF-2-alpha transcription factor network 3 165 43 -0.1 0.1 1000 -1000 -0.13 -1000
Role of Calcineurin-dependent NFAT signaling in lymphocytes 3 298 83 -0.053 0.061 1000 -1000 -0.096 -1000
E-cadherin signaling events 3 18 5 -0.011 0.01 1000 -1000 -0.059 -1000
Aurora B signaling 3 229 67 -0.27 0.048 1000 -1000 -0.094 -1000
Canonical NF-kappaB pathway 2 107 39 -0.061 0.071 1000 -1000 -0.12 -1000
BARD1 signaling events 2 141 57 -0.034 0.061 1000 -1000 -0.09 -1000
E-cadherin signaling in the nascent adherens junction 2 205 76 -0.026 0.05 1000 -1000 -0.12 -1000
Arf6 trafficking events 2 162 71 -0.064 0.042 1000 -1000 -0.099 -1000
VEGFR1 specific signals 2 137 56 -0.049 0.042 1000 -1000 -0.1 -1000
E-cadherin signaling in keratinocytes 2 95 43 -0.038 0.04 1000 -1000 -0.088 -1000
PLK2 and PLK4 events 1 4 3 0.008 0.018 1000 -1000 -0.031 -1000
Arf6 downstream pathway 1 55 43 -0.027 0.027 1000 -1000 -0.056 -1000
Aurora C signaling 1 7 7 -0.002 0.019 1000 -1000 -0.04 -1000
mTOR signaling pathway 1 80 53 -0.01 0.03 1000 -1000 -0.081 -1000
Signaling events mediated by HDAC Class I 1 158 104 -0.077 0.054 1000 -1000 -0.094 -1000
FoxO family signaling 1 107 64 -0.2 0.13 1000 -1000 -0.1 -1000
Atypical NF-kappaB pathway 1 51 31 -0.032 0.035 1000 -1000 -0.059 -1000
Alternative NF-kappaB pathway 1 17 13 -0.006 0.016 1000 -1000 -0.082 -1000
Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0 15 23 -0.002 0.044 1000 -1000 -0.092 -1000
PLK1 signaling events 0 83 85 -0.009 0.033 1000 -1000 -0.06 -1000
Insulin-mediated glucose transport 0 28 32 -0.018 0.039 1000 -1000 -0.081 -1000
Class I PI3K signaling events mediated by Akt 0 39 68 -0.039 0.052 1000 -1000 -0.071 -1000
Sumoylation by RanBP2 regulates transcriptional repression 0 3 27 0 0.032 1000 -1000 -0.067 -1000
Arf1 pathway 0 21 54 -0.013 0.026 1000 -1000 -0.055 -1000
Total 1607 92082 7203 -20 -990 131000 -131000 -12 -131000
TCGA08_retinoblastoma

Figure S1.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S1.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2B -0.14 0.28 -10000 0 -0.68 66 66
CDKN2C -0.005 0.17 -10000 0 -0.55 25 25
CDKN2A -0.29 0.34 -10000 0 -0.67 137 137
CCND2 0.15 0.19 0.35 121 -0.16 4 125
RB1 -0.15 0.21 -10000 0 -0.38 119 119
CDK4 0.17 0.21 0.39 119 -10000 0 119
CDK6 0.17 0.22 0.4 117 -10000 0 117
G1/S progression 0.15 0.21 0.38 119 -10000 0 119
IL23-mediated signaling events

Figure S2.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S2.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCL2 -0.56 0.54 -10000 0 -1.3 84 84
IL23A -0.58 0.57 -10000 0 -1.3 87 87
NF kappa B1 p50/RelA/I kappa B alpha -0.6 0.55 -10000 0 -1.3 102 102
positive regulation of T cell mediated cytotoxicity -0.67 0.68 -10000 0 -1.5 99 99
ITGA3 -0.56 0.55 -10000 0 -1.3 84 84
IL17F -0.37 0.34 -10000 0 -0.8 73 73
IL12B -0.066 0.2 -10000 0 -0.68 29 29
STAT1 (dimer) -0.63 0.64 -10000 0 -1.4 98 98
CD4 -0.56 0.54 -10000 0 -1.3 84 84
IL23 -0.58 0.54 -10000 0 -1.3 81 81
IL23R -0.08 0.14 -10000 0 -0.78 6 6
IL1B -0.61 0.6 -10000 0 -1.4 88 88
T-helper cell lineage commitment 0 0 -10000 0 -10000 0 0
IL24 -0.68 0.63 -10000 0 -1.4 109 109
TYK2 -0.004 0.018 -10000 0 -10000 0 0
STAT4 -0.015 0.14 -10000 0 -0.69 12 12
STAT3 0.013 0.001 -10000 0 -10000 0 0
IL18RAP -0.056 0.21 -10000 0 -0.72 28 28
IL12RB1 -0.058 0.19 -10000 0 -0.73 23 23
PIK3CA 0.013 0.001 -10000 0 -10000 0 0
IL12Rbeta1/TYK2 -0.048 0.15 -10000 0 -0.56 23 23
IL23R/JAK2 -0.098 0.15 -10000 0 -0.84 4 4
positive regulation of chronic inflammatory response -0.67 0.68 -10000 0 -1.5 99 99
natural killer cell activation 0.008 0.01 0.056 8 -10000 0 8
JAK2 -0.001 0.065 -10000 0 -0.63 3 3
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
NFKB1 0.009 0.003 -10000 0 -10000 0 0
RELA 0.009 0.003 -10000 0 -10000 0 0
positive regulation of dendritic cell antigen processing and presentation -0.55 0.5 -10000 0 -1.2 81 81
ALOX12B -0.7 0.61 -10000 0 -1.4 113 113
CXCL1 -0.61 0.59 -10000 0 -1.4 99 99
T cell proliferation -0.67 0.68 -10000 0 -1.5 99 99
NFKBIA 0.009 0.003 -10000 0 -10000 0 0
IL17A -0.29 0.28 -10000 0 -0.64 51 51
PI3K -0.62 0.57 -10000 0 -1.3 100 100
IFNG -0.037 0.055 0.11 5 -0.13 47 52
STAT3 (dimer) -0.59 0.53 -10000 0 -1.3 96 96
IL18R1 -0.02 0.15 -10000 0 -0.72 13 13
IL23/IL23R/JAK2/TYK2/SOCS3 -0.32 0.31 -10000 0 -0.88 33 33
IL18/IL18R -0.061 0.21 -10000 0 -0.53 46 46
macrophage activation -0.026 0.017 -10000 0 -0.052 2 2
TNF -0.61 0.59 -10000 0 -1.4 86 86
STAT3/STAT4 -0.62 0.57 -10000 0 -1.3 99 99
STAT4 (dimer) -0.64 0.64 -10000 0 -1.5 92 92
IL18 -0.018 0.14 -10000 0 -0.72 12 12
IL19 -0.6 0.55 -10000 0 -1.3 92 92
STAT5A (dimer) -0.63 0.63 -10000 0 -1.5 92 92
STAT1 0.003 0.08 -10000 0 -0.69 4 4
SOCS3 0.01 0.042 -10000 0 -0.72 1 1
CXCL9 -0.67 0.61 -10000 0 -1.4 110 110
MPO -0.58 0.55 -10000 0 -1.3 90 90
positive regulation of humoral immune response -0.67 0.68 -10000 0 -1.5 99 99
IL23/IL23R/JAK2/TYK2 -0.77 0.9 -10000 0 -1.8 98 98
IL6 -0.6 0.57 -10000 0 -1.3 90 90
STAT5A 0.013 0 -10000 0 -10000 0 0
IL2 0.004 0.037 -10000 0 -0.58 1 1
positive regulation of tyrosine phosphorylation of STAT protein 0.008 0.01 0.056 8 -10000 0 8
CD3E -0.57 0.55 -10000 0 -1.3 84 84
keratinocyte proliferation -0.67 0.68 -10000 0 -1.5 99 99
NOS2 -0.63 0.57 -10000 0 -1.3 100 100
IL4-mediated signaling events

Figure S3.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S3.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.61 0.54 -10000 0 -1.4 74 74
STAT6 (cleaved dimer) -0.65 0.55 -10000 0 -1.3 108 108
IGHG1 -0.22 0.16 -10000 0 -0.46 17 17
IGHG3 -0.59 0.52 -10000 0 -1.2 99 99
AKT1 -0.28 0.27 -10000 0 -0.79 32 32
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 -0.23 0.26 -10000 0 -0.86 24 24
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 -0.3 0.28 -10000 0 -0.82 30 30
THY1 -0.62 0.56 -10000 0 -1.4 74 74
MYB -0.1 0.25 -10000 0 -0.62 56 56
HMGA1 0.008 0.06 -10000 0 -0.72 2 2
IL4/IL4R/JAK1/IL2R gamma/JAK3 -0.38 0.34 -10000 0 -0.83 65 65
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP -0.3 0.28 -10000 0 -0.82 32 32
SP1 0.018 0.007 -10000 0 -10000 0 0
INPP5D -0.005 0.11 -10000 0 -0.67 8 8
SOCS5 0.029 0.014 -10000 0 -10000 0 0
STAT6 (dimer)/ETS1 -0.62 0.54 -10000 0 -1.3 97 97
SOCS1 -0.39 0.31 -10000 0 -0.81 67 67
SOCS3 -0.3 0.27 -10000 0 -0.94 20 20
FCER2 -0.53 0.46 -10000 0 -1.1 75 75
PARP14 0.009 0.043 -10000 0 -0.72 1 1
CCL17 -0.64 0.58 -10000 0 -1.4 82 82
GRB2 0.013 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP -0.24 0.24 -10000 0 -0.76 23 23
T cell proliferation -0.62 0.57 -10000 0 -1.4 83 83
IL4R/JAK1 -0.61 0.54 -10000 0 -1.4 74 74
EGR2 -0.64 0.57 -10000 0 -1.4 80 80
JAK2 -0.022 0.067 -10000 0 -0.64 3 3
JAK3 -0.003 0.11 -10000 0 -0.64 9 9
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
JAK1 0.001 0.042 -10000 0 -0.72 1 1
COL1A2 -0.28 0.41 -10000 0 -1.3 32 32
CCL26 -0.66 0.58 -10000 0 -1.4 98 98
IL4R -0.65 0.59 -10000 0 -1.5 75 75
PTPN6 0.025 0.043 -10000 0 -0.71 1 1
IL13RA2 -0.68 0.6 -10000 0 -1.5 91 91
IL13RA1 -0.016 0.026 -10000 0 -10000 0 0
IRF4 -0.33 0.5 -10000 0 -1.2 62 62
ARG1 -0.38 0.48 -10000 0 -1.1 73 73
CBL -0.35 0.31 -10000 0 -0.92 37 37
GTF3A 0.018 0.007 -10000 0 -10000 0 0
PIK3CA 0.013 0 -10000 0 -10000 0 0
IL13RA1/JAK2 -0.029 0.058 -10000 0 -0.49 3 3
IRF4/BCL6 -0.3 0.45 -10000 0 -1.1 58 58
CD40LG -0.13 0.28 -10000 0 -0.68 61 61
MAPK14 -0.34 0.32 -10000 0 -0.93 36 36
mitosis -0.27 0.25 -10000 0 -0.74 32 32
STAT6 -0.76 0.78 -10000 0 -1.7 95 95
SPI1 -0.03 0.12 -10000 0 -0.73 7 7
RPS6KB1 -0.26 0.24 -10000 0 -0.72 28 28
STAT6 (dimer) -0.76 0.8 -10000 0 -1.7 95 95
STAT6 (dimer)/PARP14 -0.67 0.62 -10000 0 -1.4 96 96
mast cell activation 0.015 0.011 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 -0.3 0.3 -10000 0 -0.89 34 34
FRAP1 -0.28 0.27 -10000 0 -0.79 32 32
LTA -0.64 0.58 -10000 0 -1.4 79 79
FES 0.006 0.069 -10000 0 -0.68 3 3
T-helper 1 cell differentiation 0.7 0.66 1.5 95 -10000 0 95
CCL11 -0.66 0.58 -10000 0 -1.4 86 86
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES -0.29 0.29 -10000 0 -0.85 32 32
IL2RG -0.027 0.16 -10000 0 -0.63 20 20
IL10 -0.62 0.55 -10000 0 -1.4 73 73
IRS1 -0.007 0.12 -10000 0 -0.72 8 8
IRS2 -0.002 0.099 -10000 0 -0.64 7 7
IL4 -0.14 0.1 -10000 0 -0.27 9 9
IL5 -0.61 0.54 -10000 0 -1.3 99 99
IL4/IL4R/JAK1/IL13RA1/JAK2 -0.47 0.38 -10000 0 -0.97 71 71
COL1A1 -0.3 0.45 -10000 0 -1.4 34 34
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1 -0.63 0.58 -10000 0 -1.5 73 73
IL2R gamma/JAK3 -0.027 0.16 -10000 0 -0.54 25 25
TFF3 -0.69 0.6 -10000 0 -1.5 88 88
ALOX15 -0.7 0.6 -10000 0 -1.4 97 97
MYBL1 0.006 0.069 -10000 0 -0.68 3 3
T-helper 2 cell differentiation -0.5 0.42 -10000 0 -1 87 87
SHC1 0.013 0 -10000 0 -10000 0 0
CEBPB -0.013 0.048 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 -0.28 0.28 -10000 0 -0.79 31 31
mol:PI-3-4-5-P3 -0.28 0.27 -10000 0 -0.79 32 32
PI3K -0.3 0.29 -10000 0 -0.86 33 33
DOK2 -0.019 0.15 -10000 0 -0.72 13 13
ETS1 0.023 0.059 -10000 0 -0.69 2 2
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 -0.22 0.22 -10000 0 -0.78 19 19
ITGB3 -0.63 0.57 -10000 0 -1.4 79 79
PIGR -0.84 0.64 -10000 0 -1.4 136 136
IGHE 0.026 0.05 0.3 1 -10000 0 1
MAPKKK cascade -0.22 0.22 -10000 0 -0.76 19 19
BCL6 0.013 0.003 -10000 0 -10000 0 0
OPRM1 -0.61 0.54 -10000 0 -1.3 99 99
RETNLB -0.62 0.54 -10000 0 -1.4 75 75
SELP -0.72 0.65 -10000 0 -1.5 101 101
AICDA -0.6 0.52 -10000 0 -1.3 81 81
TCGA08_p53

Figure S4.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S4.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2A -0.23 0.27 -10000 0 -0.52 137 137
TP53 -0.096 0.12 -10000 0 -0.42 19 19
Senescence -0.096 0.12 -10000 0 -0.42 19 19
Apoptosis -0.096 0.12 -10000 0 -0.42 19 19
Activated_Oncogenes 0 0 -10000 0 -10000 0 0
MDM2 0.13 0.15 0.31 101 -10000 0 101
MDM4 0.013 0 -10000 0 -10000 0 0
TCR signaling in naïve CD8+ T cells

Figure S5.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S5.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GRB2/SOS1/SHC -0.14 0.24 -10000 0 -0.63 52 52
FYN -0.14 0.38 -10000 0 -0.88 54 54
LAT/GRAP2/SLP76 -0.14 0.29 -10000 0 -0.75 50 50
IKBKB 0.013 0 -10000 0 -10000 0 0
AKT1 -0.064 0.23 -10000 0 -0.51 54 54
B2M 0.009 0.043 -10000 0 -0.73 1 1
IKBKG -0.035 0.057 -10000 0 -0.18 18 18
MAP3K8 0.008 0.054 -10000 0 -0.66 2 2
mol:Ca2+ -0.041 0.053 -10000 0 -0.12 67 67
integrin-mediated signaling pathway -0.002 0.027 -10000 0 -0.47 1 1
LAT/GRAP2/SLP76/VAV1/PI3K Class IA -0.12 0.34 -10000 0 -0.8 55 55
TRPV6 -0.21 0.31 -10000 0 -0.66 96 96
CD28 -0.044 0.19 -10000 0 -0.67 25 25
SHC1 -0.14 0.36 -10000 0 -0.83 56 56
receptor internalization -0.16 0.4 -10000 0 -0.89 59 59
PRF1 -0.16 0.42 -10000 0 -1.1 41 41
KRAS 0.013 0 -10000 0 -10000 0 0
GRB2 0.013 0 -10000 0 -10000 0 0
COT/AKT1 -0.042 0.18 -10000 0 -0.4 47 47
LAT -0.14 0.37 -10000 0 -0.89 54 54
EntrezGene:6955 0 0.004 -10000 0 -10000 0 0
CD3D -0.053 0.2 -10000 0 -0.68 29 29
CD3E -0.05 0.2 -10000 0 -0.69 27 27
CD3G -0.098 0.26 -10000 0 -0.69 48 48
RASGRP2 -0.006 0.036 -10000 0 -0.12 15 15
RASGRP1 -0.071 0.24 -10000 0 -0.54 50 50
HLA-A 0.004 0.074 -10000 0 -0.73 3 3
RASSF5 0.01 0.042 -10000 0 -0.72 1 1
RAP1A/GTP/RAPL -0.002 0.027 -10000 0 -0.47 1 1
mol:GTP 0 0 -10000 0 -10000 0 0
mol:GDP 0.003 0.069 -10000 0 -0.13 35 35
PDK1/CARD11/BCL10/MALT1/TRAF6 -0.062 0.1 -10000 0 -0.29 36 36
PRKCA -0.056 0.13 -10000 0 -0.32 45 45
GRAP2 -0.05 0.2 -10000 0 -0.67 28 28
mol:IP3 -0.052 0.24 0.25 62 -0.51 48 110
EntrezGene:6957 -0.001 0.005 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 -0.16 0.44 -10000 0 -0.94 57 57
ORAI1 0.11 0.16 0.34 96 -10000 0 96
CSK -0.14 0.37 -10000 0 -0.86 56 56
B7 family/CD28 -0.19 0.36 -10000 0 -0.9 53 53
CHUK 0.013 0 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8/LCK/ZAP-70 -0.18 0.44 -10000 0 -1 56 56
PTPN6 -0.14 0.37 -10000 0 -0.88 54 54
VAV1 -0.14 0.38 -10000 0 -0.87 56 56
Monovalent TCR/CD3 -0.11 0.35 -10000 0 -0.78 50 50
CBL 0.013 0 -10000 0 -10000 0 0
LCK -0.15 0.4 -10000 0 -0.95 54 54
PAG1 -0.15 0.37 -10000 0 -0.87 56 56
RAP1A 0.013 0 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8/LCK -0.17 0.44 -10000 0 -1 58 58
CD80 -0.021 0.15 -10000 0 -0.72 14 14
CD86 0 0.091 -10000 0 -0.7 5 5
PDK1/CARD11/BCL10/MALT1 -0.076 0.13 -10000 0 -0.34 43 43
HRAS 0.011 0.034 -10000 0 -0.58 1 1
GO:0035030 -0.1 0.3 -10000 0 -0.69 53 53
CD8A -0.11 0.26 -10000 0 -0.67 54 54
CD8B -0.14 0.29 -10000 0 -0.67 67 67
PTPRC -0.069 0.23 -10000 0 -0.69 35 35
PDK1/PKC theta -0.088 0.28 -10000 0 -0.67 49 49
CSK/PAG1 -0.14 0.36 -10000 0 -0.83 56 56
SOS1 0.013 0 -10000 0 -10000 0 0
peptide-MHC class I 0.009 0.075 -10000 0 -0.7 3 3
GRAP2/SLP76 -0.17 0.34 -10000 0 -0.84 56 56
STIM1 0.057 0.079 -10000 0 -10000 0 0
RAS family/GTP -0.001 0.093 -10000 0 -0.19 28 28
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin -0.18 0.45 -10000 0 -1 59 59
mol:DAG -0.076 0.19 -10000 0 -0.46 48 48
RAP1A/GDP 0.003 0.03 -10000 0 -10000 0 0
PLCG1 0.013 0 -10000 0 -10000 0 0
CD247 -0.044 0.19 -10000 0 -0.68 25 25
cytotoxic T cell degranulation -0.14 0.39 -10000 0 -1 42 42
RAP1A/GTP -0.005 0.011 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.087 0.27 -10000 0 -0.62 55 55
LAT/GRAP2/SLP76/VAV1/PLCgamma1 -0.088 0.31 0.27 56 -0.7 48 104
NRAS 0.013 0 -10000 0 -10000 0 0
ZAP70 -0.073 0.23 -10000 0 -0.67 38 38
GRB2/SOS1 0.019 0 -10000 0 -10000 0 0
LAT/GRAP2/SLP76/VAV1 -0.13 0.28 -10000 0 -0.71 49 49
MALT1 0.013 0 -10000 0 -10000 0 0
TRAF6 0.011 0.034 -10000 0 -0.58 1 1
CD8 heterodimer -0.17 0.34 -10000 0 -0.72 78 78
CARD11 -0.063 0.22 -10000 0 -0.68 33 33
PRKCB -0.07 0.15 -10000 0 -0.38 47 47
PRKCE -0.054 0.12 -10000 0 -0.31 44 44
PRKCQ -0.12 0.33 -10000 0 -0.75 55 55
LCP2 -0.008 0.12 -10000 0 -0.69 9 9
BCL10 0.013 0 -10000 0 -10000 0 0
regulation of survival gene product expression -0.049 0.19 -10000 0 -0.44 49 49
IKK complex 0.012 0.068 -10000 0 -0.13 15 15
RAS family/GDP -0.006 0.011 -10000 0 -10000 0 0
MAP3K14 -0.025 0.14 -10000 0 -0.31 42 42
PDPK1 -0.056 0.21 -10000 0 -0.5 47 47
TCR/CD3/MHC I/CD8/Fyn -0.19 0.46 -10000 0 -1 63 63
Signaling mediated by p38-alpha and p38-beta

Figure S6.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S6.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTGS2 -0.21 0.4 -9999 0 -1.1 39 39
MKNK1 0.013 0 -9999 0 -10000 0 0
MAPK14 -0.083 0.14 -9999 0 -0.39 12 12
ATF2/c-Jun -0.047 0.12 -9999 0 -0.54 4 4
MAPK11 -0.083 0.14 -9999 0 -0.42 7 7
MITF -0.094 0.17 -9999 0 -0.48 16 16
MAPKAPK5 -0.086 0.17 -9999 0 -0.37 57 57
KRT8 -0.2 0.27 -9999 0 -0.48 110 110
MAPKAPK3 0.013 0 -9999 0 -10000 0 0
MAPKAPK2 0.013 0 -9999 0 -10000 0 0
p38alpha-beta/CK2 -0.12 0.21 -9999 0 -0.47 57 57
CEBPB -0.086 0.17 -9999 0 -0.37 57 57
SLC9A1 -0.086 0.17 -9999 0 -0.37 57 57
mol:GDP 0 0 -9999 0 -10000 0 0
ATF2 -0.083 0.17 -9999 0 -0.5 13 13
p38alpha-beta/MNK1 -0.085 0.17 -9999 0 -0.5 12 12
JUN -0.047 0.12 -9999 0 -0.53 4 4
PPARGC1A -0.16 0.26 -9999 0 -0.62 48 48
USF1 -0.086 0.17 -9999 0 -0.37 57 57
RAB5/GDP/GDI1 -0.078 0.1 -9999 0 -0.41 6 6
NOS2 -0.21 0.38 -9999 0 -1.2 29 29
DDIT3 -0.091 0.17 -9999 0 -0.38 60 60
RAB5A 0.013 0 -9999 0 -10000 0 0
HSPB1 -0.062 0.14 -9999 0 -0.49 7 7
p38alpha-beta/HBP1 -0.085 0.17 -9999 0 -0.5 12 12
CREB1 -0.085 0.17 -9999 0 -0.38 58 58
RAB5/GDP 0.009 0 -9999 0 -10000 0 0
EIF4E -0.068 0.15 -9999 0 -0.54 6 6
RPS6KA4 -0.086 0.17 -9999 0 -0.37 57 57
PLA2G4A -0.11 0.21 -9999 0 -0.6 27 27
GDI1 -0.086 0.17 -9999 0 -0.37 57 57
TP53 -0.13 0.22 -9999 0 -0.5 63 63
RPS6KA5 -0.089 0.17 -9999 0 -0.38 59 59
ESR1 -0.14 0.22 -9999 0 -0.44 86 86
HBP1 0.013 0 -9999 0 -10000 0 0
MEF2C -0.12 0.2 -9999 0 -0.53 26 26
MEF2A -0.086 0.17 -9999 0 -0.47 12 12
EIF4EBP1 -0.086 0.17 -9999 0 -0.38 58 58
KRT19 -0.29 0.29 -9999 0 -0.51 161 161
ELK4 -0.086 0.17 -9999 0 -0.37 57 57
ATF6 -0.086 0.17 -9999 0 -0.47 12 12
ATF1 -0.085 0.17 -9999 0 -0.38 58 58
p38alpha-beta/MAPKAPK2 -0.085 0.17 -9999 0 -0.5 12 12
p38alpha-beta/MAPKAPK3 -0.085 0.17 -9999 0 -0.5 12 12
IL12-mediated signaling events

Figure S7.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S7.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IL12/IL12R/TYK2/JAK2/SOCS1 -0.12 0.23 -10000 0 -0.51 50 50
TBX21 -0.3 0.58 -10000 0 -1.4 56 56
B2M 0.009 0.043 -10000 0 -0.72 1 1
TYK2 0.011 0.021 -10000 0 -10000 0 0
IL12RB1 -0.043 0.2 -10000 0 -0.72 23 23
GADD45B -0.2 0.42 -10000 0 -1.1 42 42
IL12RB2 -0.14 0.29 -10000 0 -0.7 64 64
GADD45G -0.22 0.46 -10000 0 -1.1 54 54
natural killer cell activation 0 0.024 -10000 0 -10000 0 0
RELB 0.009 0.048 -10000 0 -0.58 2 2
RELA 0.013 0 -10000 0 -10000 0 0
IL18 -0.017 0.14 -10000 0 -0.73 12 12
IL2RA -0.023 0.16 -10000 0 -0.72 15 15
IFNG -0.14 0.29 -10000 0 -0.67 68 68
STAT3 (dimer) -0.2 0.4 -10000 0 -0.88 62 62
HLA-DRB5 -0.058 0.21 -10000 0 -0.66 32 32
FASLG -0.34 0.61 -10000 0 -1.4 67 67
NF kappa B2 p52/RelB -0.32 0.47 -10000 0 -1.1 66 66
CD4 -0.007 0.12 -10000 0 -0.72 8 8
SOCS1 -0.002 0.099 -10000 0 -0.64 7 7
EntrezGene:6955 -0.001 0.012 -10000 0 -10000 0 0
CD3D -0.053 0.2 -10000 0 -0.67 29 29
CD3E -0.05 0.2 -10000 0 -0.68 27 27
CD3G -0.098 0.26 -10000 0 -0.69 48 48
IL12Rbeta2/JAK2 -0.1 0.23 -10000 0 -0.53 66 66
CCL3 -0.28 0.53 -10000 0 -1.2 56 56
CCL4 -0.28 0.54 -10000 0 -1.3 54 54
HLA-A 0.005 0.073 -10000 0 -0.72 3 3
IL18/IL18R -0.043 0.22 -10000 0 -0.53 47 47
NOS2 -0.32 0.57 -10000 0 -1.3 62 62
IL12/IL12R/TYK2/JAK2/SPHK2 -0.11 0.22 -10000 0 -0.49 48 48
IL1R1 -0.26 0.5 -10000 0 -1.1 61 61
IL4 0 0.024 -10000 0 -10000 0 0
JAK2 0.005 0.063 -10000 0 -0.59 3 3
EntrezGene:6957 -0.001 0.012 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 -0.23 0.55 -10000 0 -1.1 64 64
RAB7A -0.15 0.36 -10000 0 -0.86 36 36
lysosomal transport -0.14 0.34 -10000 0 -0.8 37 37
FOS -0.19 0.44 -10000 0 -1.1 47 47
STAT4 (dimer) -0.23 0.46 -10000 0 -1 58 58
STAT5A (dimer) -0.37 0.49 -10000 0 -1.1 76 76
GZMA -0.3 0.57 -10000 0 -1.3 60 60
GZMB -0.28 0.56 -10000 0 -1.3 58 58
HLX 0.013 0 -10000 0 -10000 0 0
LCK -0.31 0.6 -10000 0 -1.3 68 68
TCR/CD3/MHC II/CD4 -0.13 0.4 -10000 0 -0.92 45 45
IL2/IL2R -0.047 0.21 -10000 0 -0.61 30 30
MAPK14 -0.21 0.45 -10000 0 -1.1 48 48
CCR5 -0.25 0.52 -10000 0 -1.2 53 53
IL1B -0.074 0.23 -10000 0 -0.67 38 38
STAT6 -0.047 0.13 -10000 0 -10000 0 0
STAT4 -0.015 0.14 -10000 0 -0.69 12 12
STAT3 0.013 0 -10000 0 -10000 0 0
STAT1 0.003 0.08 -10000 0 -0.69 4 4
NFKB1 0.013 0 -10000 0 -10000 0 0
NFKB2 0.013 0 -10000 0 -10000 0 0
IL12B -0.052 0.2 -10000 0 -0.66 29 29
CD8A -0.11 0.26 -10000 0 -0.67 54 54
CD8B -0.14 0.28 -10000 0 -0.67 67 67
T-helper 1 cell differentiation 0 0 -10000 0 -10000 0 0
natural killer cell mediated cytotoxicity 0.12 0.23 0.51 50 -10000 0 50
IL2RB -0.034 0.18 -10000 0 -0.69 20 20
proteasomal ubiquitin-dependent protein catabolic process -0.2 0.41 -10000 0 -0.9 58 58
IL2RG -0.03 0.16 -10000 0 -0.63 20 20
IL12 -0.068 0.21 -10000 0 -0.52 50 50
STAT5A 0.013 0 -10000 0 -10000 0 0
CD247 -0.044 0.19 -10000 0 -0.67 25 25
IL2 0.003 0.034 -10000 0 -0.58 1 1
SPHK2 0.013 0 -10000 0 -10000 0 0
FRAP1 0 0 -10000 0 -10000 0 0
IL12A -0.042 0.18 -10000 0 -0.65 24 24
IL12/IL12R/TYK2/JAK2 -0.35 0.71 -10000 0 -1.5 68 68
MAP2K3 -0.21 0.45 -10000 0 -1 56 56
RIPK2 0.013 0 -10000 0 -10000 0 0
MAP2K6 -0.22 0.47 -10000 0 -1 54 54
regulation of dendritic cell antigen processing and presentation 0 0 -10000 0 -10000 0 0
HLA-DRA -0.028 0.17 -10000 0 -0.72 17 17
IL18RAP -0.055 0.21 -10000 0 -0.72 28 28
IL12Rbeta1/TYK2 -0.026 0.16 -10000 0 -0.56 23 23
EOMES -0.11 0.4 -10000 0 -1.3 28 28
STAT1 (dimer) -0.25 0.43 -10000 0 -0.93 67 67
T cell proliferation -0.13 0.33 -10000 0 -0.72 47 47
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
IL18R1 -0.019 0.15 -10000 0 -0.72 13 13
CD8-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA -0.23 0.31 -10000 0 -0.82 47 47
ATF2 -0.18 0.41 -10000 0 -0.96 46 46
p75(NTR)-mediated signaling

Figure S8.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S8.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Sortilin/TRAF6 0.006 0.082 -9999 0 -0.53 7 7
Necdin/E2F1 -0.018 0.13 -9999 0 -0.49 22 22
proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E -0.13 0.21 -9999 0 -0.75 14 14
NGF (dimer)/p75(NTR)/BEX1 -0.17 0.24 -9999 0 -0.46 110 110
NT-4/5 (dimer)/p75(NTR) -0.045 0.17 -9999 0 -0.5 37 37
IKBKB 0.013 0 -9999 0 -10000 0 0
AKT1 -0.089 0.21 -9999 0 -0.73 11 11
IKBKG 0.01 0.042 -9999 0 -0.72 1 1
BDNF -0.1 0.25 -9999 0 -0.65 53 53
MGDIs/NGR/p75(NTR)/LINGO1 -0.065 0.16 -9999 0 -0.43 46 46
FURIN 0.013 0 -9999 0 -10000 0 0
proBDNF (dimer)/p75(NTR)/Sortilin -0.12 0.21 -9999 0 -0.45 85 85
LINGO1 -0.007 0.12 -9999 0 -0.66 9 9
Sortilin/TRAF6/NRIF -0.01 0.056 -9999 0 -10000 0 0
proBDNF (dimer) -0.1 0.25 -9999 0 -0.65 53 53
NTRK1 -0.024 0.15 -9999 0 -0.67 16 16
RTN4R 0.003 0.084 -9999 0 -0.72 4 4
neuron apoptosis -0.12 0.24 -9999 0 -0.62 35 35
IRAK1 0.013 0 -9999 0 -10000 0 0
SHC1 -0.12 0.24 -9999 0 -0.47 87 87
ARHGDIA 0.013 0 -9999 0 -10000 0 0
RhoA/GTP 0.009 0 -9999 0 -10000 0 0
Gamma Secretase -0.002 0.023 -9999 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 -0.11 0.23 -9999 0 -0.5 64 64
MAGEH1 0.003 0.08 -9999 0 -0.69 4 4
proNGF (dimer)/p75(NTR)/Sortilin/Necdin -0.13 0.25 -9999 0 -0.52 68 68
Mammalian IAPs/DIABLO -0.005 0.13 -9999 0 -0.54 9 9
proNGF (dimer) -0.13 0.28 -9999 0 -0.68 64 64
MAGED1 -0.007 0.12 -9999 0 -0.72 8 8
APP 0.013 0 -9999 0 -10000 0 0
NT-4/5 (dimer) 0.003 0.08 -9999 0 -0.69 4 4
ZNF274 0.01 0.042 -9999 0 -0.72 1 1
RhoA/GDP/RHOGDI -0.094 0.21 -9999 0 -0.46 56 56
NGF -0.13 0.28 -9999 0 -0.68 64 64
cell cycle arrest -0.11 0.21 -9999 0 -0.44 62 62
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK -0.057 0.16 -9999 0 -0.56 12 12
NT-4/5 (dimer)/p75(NTR)/TRAF6 -0.053 0.15 -9999 0 -0.43 37 37
NCSTN 0.013 0 -9999 0 -10000 0 0
mol:GTP -0.14 0.24 -9999 0 -0.49 90 90
PSENEN 0.009 0.048 -9999 0 -0.58 2 2
mol:ceramide -0.11 0.22 -9999 0 -0.48 62 62
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs -0.038 0.14 -9999 0 -0.46 13 13
p75(NTR)/beta APP -0.038 0.16 -9999 0 -0.49 34 34
BEX1 -0.043 0.17 -9999 0 -0.58 27 27
mol:GDP -0.12 0.24 -9999 0 -0.48 87 87
NGF (dimer) -0.17 0.24 -9999 0 -0.48 90 90
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI -0.03 0.15 -9999 0 -0.44 26 26
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
RAC1/GTP -0.12 0.2 -9999 0 -0.47 56 56
MYD88 0.013 0 -9999 0 -10000 0 0
CHUK 0.013 0 -9999 0 -10000 0 0
NGF (dimer)/p75(NTR)/PKA -0.15 0.24 -9999 0 -0.49 90 90
RHOB 0.009 0.048 -9999 0 -0.58 2 2
RHOA 0.013 0 -9999 0 -10000 0 0
MAGE-G1/E2F1 0.012 0.056 -9999 0 -0.42 5 5
NT3 (dimer) -0.12 0.27 -9999 0 -0.65 60 60
TP53 -0.094 0.22 -9999 0 -0.68 17 17
PRDM4 -0.11 0.23 -9999 0 -0.49 62 62
BDNF (dimer) -0.28 0.3 -9999 0 -0.49 179 179
PIK3CA 0.013 0 -9999 0 -10000 0 0
SORT1 -0.002 0.1 -9999 0 -0.72 6 6
activation of caspase activity -0.13 0.2 -9999 0 -0.74 14 14
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 -0.11 0.23 -9999 0 -0.5 62 62
RHOC 0.013 0 -9999 0 -10000 0 0
XIAP 0.013 0 -9999 0 -10000 0 0
MAPK10 -0.14 0.23 -9999 0 -0.58 40 40
DIABLO 0.013 0 -9999 0 -10000 0 0
SMPD2 -0.11 0.23 -9999 0 -0.49 62 62
APH1B 0.013 0 -9999 0 -10000 0 0
APH1A 0.013 0 -9999 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin -0.14 0.24 -9999 0 -0.48 92 92
PSEN1 0.013 0 -9999 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.019 0 -9999 0 -10000 0 0
NT3 (dimer)/p75(NTR) -0.13 0.26 -9999 0 -0.53 84 84
MAPK8 -0.1 0.21 -9999 0 -0.57 28 28
MAPK9 -0.1 0.21 -9999 0 -0.58 27 27
APAF1 0.013 0 -9999 0 -10000 0 0
NTF3 -0.12 0.27 -9999 0 -0.65 60 60
NTF4 0.003 0.08 -9999 0 -0.69 4 4
NDN -0.027 0.16 -9999 0 -0.66 18 18
RAC1/GDP 0.009 0 -9999 0 -10000 0 0
RhoA-B-C/GDP -0.12 0.19 -9999 0 -0.69 15 15
p75 CTF/Sortilin/TRAF6/NRIF 0.018 0.079 -9999 0 -0.42 9 9
RhoA-B-C/GTP -0.14 0.24 -9999 0 -0.49 90 90
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF -0.11 0.18 -9999 0 -0.45 49 49
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 -0.091 0.21 -9999 0 -0.48 48 48
PRKACB -0.004 0.11 -9999 0 -0.72 7 7
proBDNF (dimer)/p75 ECD -0.071 0.2 -9999 0 -0.49 54 54
ChemicalAbstracts:86-01-1 0 0 -9999 0 -10000 0 0
BIRC3 -0.038 0.17 -9999 0 -0.61 25 25
BIRC2 -0.001 0.09 -9999 0 -0.58 7 7
neuron projection morphogenesis -0.13 0.24 -9999 0 -0.54 59 59
BAD -0.11 0.21 -9999 0 -0.56 30 30
RIPK2 0.013 0 -9999 0 -10000 0 0
NGFR -0.063 0.21 -9999 0 -0.66 34 34
CYCS -0.11 0.22 -9999 0 -0.76 13 13
ADAM17 0.008 0.06 -9999 0 -0.72 2 2
NGF (dimer)/p75(NTR)/TRAF6/RIP2 -0.1 0.22 -9999 0 -0.5 56 56
BCL2L11 -0.11 0.21 -9999 0 -0.56 30 30
BDNF (dimer)/p75(NTR) -0.12 0.24 -9999 0 -0.52 80 80
PI3K -0.1 0.22 -9999 0 -0.49 57 57
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 -0.11 0.23 -9999 0 -0.49 62 62
NDNL2 0.013 0 -9999 0 -10000 0 0
YWHAE 0.013 0 -9999 0 -10000 0 0
PRKCI 0.013 0 -9999 0 -10000 0 0
NGF (dimer)/p75(NTR) -0.14 0.27 -9999 0 -0.55 87 87
ChemicalAbstracts:146-91-8 0 0 -9999 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/NRAGE -0.12 0.24 -9999 0 -0.5 68 68
TRAF6 0.011 0.034 -9999 0 -0.58 1 1
RAC1 0.013 0 -9999 0 -10000 0 0
PRKCZ 0.01 0.042 -9999 0 -0.72 1 1
PLG 0 0 -9999 0 -10000 0 0
oligodendrocyte cell fate commitment 0 0 -9999 0 -10000 0 0
CASP6 -0.15 0.26 -9999 0 -0.65 40 40
SQSTM1 0.01 0.042 -9999 0 -0.72 1 1
NGFRAP1 0.003 0.084 -9999 0 -0.72 4 4
CASP3 -0.097 0.2 -9999 0 -0.52 27 27
E2F1 0.003 0.076 -9999 0 -0.58 5 5
CASP9 0.013 0 -9999 0 -10000 0 0
IKK complex -0.11 0.17 -9999 0 -0.58 15 15
NGF (dimer)/TRKA -0.12 0.24 -9999 0 -0.51 79 79
MMP7 -0.17 0.31 -9999 0 -0.67 82 82
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF -0.12 0.2 -9999 0 -0.46 63 63
MMP3 -0.2 0.32 -9999 0 -0.66 97 97
APAF-1/Caspase 9 -0.12 0.18 -9999 0 -0.58 24 24
Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Figure S9.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S9.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FOXP3 -0.042 0.21 -10000 0 -0.78 22 22
NFATC2 -0.12 0.33 -10000 0 -0.93 32 32
NFATC3 -0.023 0.078 -10000 0 -10000 0 0
CD40LG -0.4 0.5 -10000 0 -1.2 68 68
ITCH -0.024 0.13 -10000 0 -0.53 1 1
CBLB -0.023 0.12 -10000 0 -10000 0 0
CD4-positive CD25-positive alpha-beta regulatory T cell lineage commitment -0.29 0.47 -10000 0 -1.4 38 38
JUNB 0.013 0 -10000 0 -10000 0 0
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.073 0.13 -10000 0 -10000 0 0
T cell anergy -0.079 0.2 -10000 0 -0.47 45 45
TLE4 -0.075 0.27 -10000 0 -0.91 20 20
Jun/NFAT1-c-4/p21SNFT -0.24 0.4 -10000 0 -1.1 32 32
AP-1/NFAT1-c-4 -0.41 0.55 -10000 0 -1.3 63 63
IKZF1 -0.12 0.35 -10000 0 -1 32 32
T-helper 2 cell differentiation -0.13 0.3 -10000 0 -0.85 36 36
AP-1/NFAT1 -0.16 0.25 -10000 0 -0.7 41 41
CALM1 -0.018 0.081 -10000 0 -10000 0 0
EGR2 -0.18 0.44 -10000 0 -1.6 20 20
EGR3 -0.16 0.38 -10000 0 -1.3 18 18
NFAT1/FOXP3 -0.12 0.38 -10000 0 -1.1 32 32
EGR1 0 0.088 -10000 0 -0.67 5 5
JUN -0.01 0.046 -10000 0 -0.64 1 1
EGR4 -0.13 0.27 -10000 0 -0.65 64 64
mol:Ca2+ -0.033 0.086 -10000 0 -10000 0 0
GBP3 -0.14 0.37 -10000 0 -0.96 44 44
FOSL1 -0.046 0.2 -10000 0 -0.72 24 24
NFAT1-c-4/MAF/IRF4 -0.26 0.42 -10000 0 -1.2 35 35
DGKA -0.069 0.25 -10000 0 -0.84 20 20
CREM 0.012 0.001 -10000 0 -10000 0 0
NFAT1-c-4/PPARG -0.26 0.42 -10000 0 -1.2 37 37
CTLA4 -0.13 0.42 -10000 0 -1.2 31 31
NFAT1-c-4 (dimer)/EGR1 -0.19 0.4 -10000 0 -1.1 31 31
NFAT1-c-4 (dimer)/EGR4 -0.27 0.41 -10000 0 -1.1 40 40
FOS -0.054 0.18 -10000 0 -0.7 20 20
IFNG -0.38 0.57 -10000 0 -1.3 78 78
T cell activation -0.13 0.25 -10000 0 -0.83 13 13
MAF -0.014 0.14 -10000 0 -0.72 11 11
T-helper 2 cell lineage commitment 0 0 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.11 0.24 0.87 8 -10000 0 8
TNF -0.27 0.42 -10000 0 -1.1 45 45
FASLG -0.35 0.65 -10000 0 -1.6 55 55
TBX21 -0.091 0.24 -10000 0 -0.7 39 39
BATF3 -0.001 0.097 -10000 0 -0.68 6 6
PRKCQ -0.044 0.19 -10000 0 -0.72 21 21
PTPN1 -0.069 0.25 -10000 0 -0.84 20 20
NFAT1-c-4/ICER1 -0.2 0.37 -10000 0 -1.1 30 30
GATA3 -0.021 0.15 -10000 0 -0.68 15 15
T-helper 1 cell differentiation -0.34 0.56 -10000 0 -1.2 78 78
IL2RA -0.27 0.42 -10000 0 -1.2 38 38
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
CASP3 -0.069 0.25 -10000 0 -0.82 21 21
E2F1 0.009 0.076 -10000 0 -0.58 5 5
PPARG -0.096 0.25 -10000 0 -0.65 50 50
SLC3A2 -0.069 0.25 -10000 0 -0.82 21 21
IRF4 -0.11 0.26 -10000 0 -0.64 55 55
PTGS2 -0.41 0.5 -10000 0 -1.1 76 76
CSF2 -0.42 0.5 -10000 0 -1.1 74 74
JunB/Fra1/NFAT1-c-4 -0.2 0.38 -10000 0 -1.1 30 30
IL4 -0.14 0.32 -10000 0 -0.91 36 36
IL5 -0.35 0.44 -10000 0 -1 67 67
IL2 -0.14 0.26 -10000 0 -0.84 13 13
IL3 -0.069 0.087 -10000 0 -1.2 1 1
RNF128 -0.14 0.33 -10000 0 -0.72 72 72
NFATC1 -0.11 0.24 -10000 0 -0.88 8 8
CDK4 0.088 0.19 0.75 2 -10000 0 2
PTPRK -0.072 0.26 -10000 0 -0.83 22 22
IL8 -0.4 0.49 -10000 0 -1.2 65 65
POU2F1 0.01 0.042 -10000 0 -0.72 1 1
HIF-1-alpha transcription factor network

Figure S10.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S10.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PKM2 -0.31 0.54 -9999 0 -1.3 37 37
HDAC7 0.014 0.004 -9999 0 -10000 0 0
HIF1A/ARNT/Cbp/p300/Src-1 -0.28 0.36 -9999 0 -0.96 23 23
SMAD4 0.012 0.042 -9999 0 -0.72 1 1
ID2 -0.32 0.55 -9999 0 -1.3 38 38
AP1 -0.015 0.13 -9999 0 -0.5 21 21
ABCG2 -0.32 0.56 -9999 0 -1.3 41 41
HIF1A -0.027 0.083 -9999 0 -10000 0 0
TFF3 -0.38 0.59 -9999 0 -1.3 54 54
GATA2 0.004 0.084 -9999 0 -0.72 4 4
AKT1 -0.036 0.095 -9999 0 -10000 0 0
response to hypoxia -0.055 0.1 -9999 0 -10000 0 0
MCL1 -0.31 0.54 -9999 0 -1.3 39 39
NDRG1 -0.32 0.55 -9999 0 -1.3 37 37
SERPINE1 -0.35 0.58 -9999 0 -1.3 50 50
FECH -0.31 0.54 -9999 0 -1.3 38 38
FURIN -0.31 0.54 -9999 0 -1.3 37 37
NCOA2 0 0.094 -9999 0 -0.72 5 5
EP300 -0.034 0.14 -9999 0 -0.36 7 7
HMOX1 -0.32 0.54 -9999 0 -1.3 39 39
BHLHE40 -0.31 0.54 -9999 0 -1.3 38 38
BHLHE41 -0.33 0.56 -9999 0 -1.3 42 42
HIF1A/ARNT/SMAD3/SMAD4/SP1 -0.039 0.069 -9999 0 -0.5 2 2
ENG 0.013 0.12 -9999 0 -0.81 1 1
JUN 0.011 0.034 -9999 0 -0.58 1 1
RORA -0.32 0.55 -9999 0 -1.3 41 41
ABCB1 -0.17 0.36 -9999 0 -1.2 28 28
TFRC -0.32 0.55 -9999 0 -1.3 39 39
CXCR4 -0.33 0.56 -9999 0 -1.3 41 41
TF -0.43 0.6 -9999 0 -1.3 60 60
CITED2 -0.31 0.54 -9999 0 -1.3 41 41
HIF1A/ARNT -0.43 0.59 -9999 0 -1.5 48 48
LDHA -0.041 0.052 -9999 0 -10000 0 0
ETS1 -0.31 0.54 -9999 0 -1.3 37 37
PGK1 -0.31 0.54 -9999 0 -1.3 37 37
NOS2 -0.38 0.59 -9999 0 -1.3 52 52
ITGB2 -0.32 0.56 -9999 0 -1.3 42 42
ALDOA -0.31 0.54 -9999 0 -1.3 37 37
Cbp/p300/CITED2 -0.34 0.54 -9999 0 -1.3 42 42
FOS -0.032 0.17 -9999 0 -0.67 20 20
HK2 -0.31 0.54 -9999 0 -1.3 37 37
SP1 0.017 0.018 -9999 0 -10000 0 0
GCK -0.14 0.41 -9999 0 -1.2 25 25
HK1 -0.31 0.54 -9999 0 -1.3 37 37
NPM1 -0.31 0.54 -9999 0 -1.3 37 37
EGLN1 -0.31 0.54 -9999 0 -1.3 37 37
CREB1 0.02 0 -9999 0 -10000 0 0
PGM1 -0.31 0.54 -9999 0 -1.3 38 38
SMAD3 0.012 0.042 -9999 0 -0.72 1 1
EDN1 -0.055 0.26 -9999 0 -1.2 8 8
IGFBP1 -0.33 0.55 -9999 0 -1.3 41 41
VEGFA -0.18 0.38 -9999 0 -0.88 8 8
HIF1A/JAB1 -0.023 0.031 -9999 0 -10000 0 0
CP -0.44 0.61 -9999 0 -1.3 63 63
CXCL12 -0.35 0.57 -9999 0 -1.3 47 47
COPS5 0.012 0.006 -9999 0 -10000 0 0
SMAD3/SMAD4 -0.004 0.044 -9999 0 -0.54 2 2
BNIP3 -0.32 0.55 -9999 0 -1.3 42 42
EGLN3 -0.34 0.57 -9999 0 -1.3 44 44
CA9 -0.4 0.6 -9999 0 -1.4 53 53
TERT -0.35 0.56 -9999 0 -1.3 44 44
ENO1 -0.31 0.54 -9999 0 -1.3 37 37
PFKL -0.31 0.54 -9999 0 -1.3 37 37
NCOA1 0.013 0.002 -9999 0 -10000 0 0
ADM -0.32 0.55 -9999 0 -1.3 42 42
ARNT -0.027 0.081 -9999 0 -10000 0 0
HNF4A -0.038 0.16 -9999 0 -0.61 20 20
ADFP -0.34 0.52 -9999 0 -1.2 46 46
SLC2A1 -0.19 0.39 -9999 0 -1 10 10
LEP -0.36 0.56 -9999 0 -1.3 40 40
HIF1A/ARNT/Cbp/p300 -0.29 0.37 -9999 0 -0.96 28 28
EPO -0.18 0.39 -9999 0 -0.98 25 25
CREBBP -0.034 0.14 -9999 0 -0.36 7 7
HIF1A/ARNT/Cbp/p300/HDAC7 -0.27 0.36 -9999 0 -0.99 19 19
PFKFB3 -0.31 0.54 -9999 0 -1.3 41 41
NT5E -0.35 0.59 -9999 0 -1.3 50 50
Effects of Botulinum toxin

Figure S11.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S11.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
STX1A 0.009 0.032 -9999 0 -0.55 1 1
UniProt:P19321 0 0 -9999 0 -10000 0 0
RIMS1/UNC13B -0.028 0.13 -9999 0 -0.43 30 30
STXBP1 0.001 0.094 -9999 0 -0.72 5 5
ACh/CHRNA1 -0.21 0.22 -9999 0 -0.44 145 145
RAB3GAP2/RIMS1/UNC13B -0.035 0.11 -9999 0 -0.47 1 1
mol:Ca2+ 0 0 -9999 0 -10000 0 0
UniProt:P30996 0 0 -9999 0 -10000 0 0
UniProt:Q60393 0 0 -9999 0 -10000 0 0
CST086 0 0 -9999 0 -10000 0 0
RIMS1 -0.047 0.17 -9999 0 -0.58 28 28
mol:ACh -0.004 0.041 -9999 0 -0.12 29 29
RAB3GAP2 0.013 0 -9999 0 -10000 0 0
STX1A/SNAP25/VAMP2 -0.044 0.1 -9999 0 -0.61 3 3
UniProt:P10844 0 0 -9999 0 -10000 0 0
muscle contraction -0.21 0.22 -9999 0 -0.43 145 145
UNC13B 0.008 0.054 -9999 0 -0.66 2 2
CHRNA1 -0.3 0.33 -9999 0 -0.64 145 145
UniProt:P10845 0 0 -9999 0 -10000 0 0
ACh/Synaptotagmin 1 -0.11 0.21 -9999 0 -0.48 74 74
SNAP25 -0.023 0.095 -9999 0 -0.31 29 29
VAMP2 0.007 0 -9999 0 -10000 0 0
SYT1 -0.16 0.3 -9999 0 -0.69 74 74
UniProt:Q00496 0 0 -9999 0 -10000 0 0
STXIA/STXBP1 0.008 0.076 -9999 0 -0.56 5 5
STX1A/SNAP25 fragment 1/VAMP2 -0.044 0.1 -9999 0 -0.61 3 3
Glypican 2 network

Figure S12.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S12.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MDK -0.012 0.13 -9999 0 -0.67 11 11
GPC2 -0.048 0.2 -9999 0 -0.67 27 27
GPC2/Midkine -0.045 0.18 -9999 0 -0.52 36 36
neuron projection morphogenesis -0.045 0.18 -9999 0 -0.52 36 36
Wnt signaling

Figure S13.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S13.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Noncanonical Wnts/FZD -0.12 0.25 -9999 0 -0.72 29 29
FZD6 0.013 0 -9999 0 -10000 0 0
WNT6 -0.077 0.23 -9999 0 -0.65 41 41
WNT4 -0.048 0.2 -9999 0 -0.67 27 27
FZD3 -0.021 0.15 -9999 0 -0.71 14 14
WNT5A -0.023 0.16 -9999 0 -0.71 15 15
WNT11 -0.13 0.27 -9999 0 -0.64 68 68
amb2 Integrin signaling

Figure S14.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S14.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaM/beta2 Integrin/proMMP-2 -0.1 0.23 -9999 0 -0.56 52 52
alphaM/beta2 Integrin/GPIbA -0.1 0.22 -9999 0 -0.59 38 38
alphaM/beta2 Integrin/proMMP-9 -0.11 0.25 -9999 0 -0.6 52 52
PLAUR 0.008 0.054 -9999 0 -0.66 2 2
HMGB1 0.006 0.02 -9999 0 -10000 0 0
alphaM/beta2 Integrin/Talin -0.069 0.19 -9999 0 -0.57 33 33
AGER -0.012 0.11 -9999 0 -0.66 8 8
RAP1A 0.013 0 -9999 0 -10000 0 0
SELPLG 0.003 0.084 -9999 0 -0.72 4 4
mol:LDL 0 0 -9999 0 -10000 0 0
alphaM/beta2 Integrin/RAGE/HMGB1 -0.11 0.2 -9999 0 -0.62 32 32
mol:GTP 0 0 -9999 0 -10000 0 0
MMP9 -0.057 0.2 -9999 0 -0.65 32 32
CYR61 -0.004 0.1 -9999 0 -0.64 8 8
TLN1 0.011 0.034 -9999 0 -0.58 1 1
Rap1/GTP -0.12 0.19 -9999 0 -0.64 23 23
RHOA 0.013 0 -9999 0 -10000 0 0
P-selectin oligomer -0.14 0.29 -9999 0 -0.7 66 66
MYH2 -0.32 0.25 -9999 0 -0.59 101 101
MST1R -0.024 0.16 -9999 0 -0.72 15 15
leukocyte activation during inflammatory response -0.11 0.2 -9999 0 -0.51 42 42
APOB -0.056 0.19 -9999 0 -0.6 33 33
mol:GDP 0 0 -9999 0 -10000 0 0
complement component iC3b receptor activity 0 0 -9999 0 -10000 0 0
MMP2 -0.044 0.19 -9999 0 -0.67 25 25
JAM3 0.011 0.034 -9999 0 -0.58 1 1
GP1BA -0.046 0.18 -9999 0 -0.63 27 27
alphaM/beta2 Integrin/CTGF -0.092 0.22 -9999 0 -0.66 33 33
alphaM/beta2 Integrin -0.12 0.24 -9999 0 -0.59 42 42
JAM3 homodimer 0.011 0.034 -9999 0 -0.58 1 1
ICAM2 0.008 0.06 -9999 0 -0.72 2 2
ICAM1 -0.004 0.11 -9999 0 -0.7 7 7
phagocytosis triggered by activation of immune response cell surface activating receptor -0.12 0.24 -9999 0 -0.58 42 42
cell adhesion -0.1 0.22 -9999 0 -0.59 38 38
NFKB1 -0.097 0.28 -9999 0 -0.74 34 34
THY1 -0.018 0.14 -9999 0 -0.69 13 13
RhoA/GDP 0.009 0 -9999 0 -10000 0 0
Lipoprotein(a) -0.059 0.14 -9999 0 -0.4 45 45
alphaM/beta2 Integrin/LRP/tPA -0.087 0.2 -9999 0 -0.57 34 34
IL6 -0.14 0.37 -9999 0 -0.93 43 43
ITGB2 -0.029 0.15 -9999 0 -0.68 15 15
elevation of cytosolic calcium ion concentration -0.07 0.19 -9999 0 -0.6 28 28
alphaM/beta2 Integrin/JAM2/JAM3 -0.082 0.21 -9999 0 -0.63 31 31
JAM2 -0.024 0.16 -9999 0 -0.68 16 16
alphaM/beta2 Integrin/ICAM1 -0.094 0.21 -9999 0 -0.66 26 26
alphaM/beta2 Integrin/uPA/Plg -0.071 0.19 -9999 0 -0.56 32 32
RhoA/GTP -0.13 0.23 -9999 0 -0.62 32 32
positive regulation of phagocytosis -0.12 0.22 -9999 0 -0.74 25 25
Ron/MSP -0.025 0.15 -9999 0 -0.51 25 25
alphaM/beta2 Integrin/uPAR/uPA -0.071 0.19 -9999 0 -0.61 28 28
alphaM/beta2 Integrin/uPAR -0.07 0.19 -9999 0 -0.62 28 28
PLAU -0.002 0.1 -9999 0 -0.72 6 6
PLAT -0.034 0.17 -9999 0 -0.63 22 22
actin filament polymerization -0.3 0.23 -9999 0 -0.56 101 101
MST1 -0.008 0.12 -9999 0 -0.63 10 10
alphaM/beta2 Integrin/lipoprotein(a) -0.11 0.2 -9999 0 -0.54 38 38
TNF -0.12 0.34 -9999 0 -0.91 37 37
RAP1B 0.009 0.048 -9999 0 -0.58 2 2
alphaM/beta2 Integrin/uPA -0.077 0.2 -9999 0 -0.61 32 32
fibrinolysis -0.07 0.18 -9999 0 -0.56 32 32
HCK -0.006 0.12 -9999 0 -0.71 8 8
dendritic cell antigen processing and presentation -0.12 0.24 -9999 0 -0.58 42 42
VTN -0.034 0.17 -9999 0 -0.66 21 21
alphaM/beta2 Integrin/CYR61 -0.078 0.2 -9999 0 -0.58 37 37
LPA -0.022 0.13 -9999 0 -0.59 15 15
LRP1 0.01 0.042 -9999 0 -0.72 1 1
cell migration -0.11 0.28 -9999 0 -0.62 55 55
FN1 -0.098 0.25 -9999 0 -0.66 50 50
alphaM/beta2 Integrin/Thy1 -0.086 0.22 -9999 0 -0.65 34 34
MPO -0.035 0.17 -9999 0 -0.67 21 21
KNG1 -0.006 0.082 -9999 0 -0.58 6 6
RAP1/GDP -0.002 0.029 -9999 0 -0.36 2 2
ROCK1 -0.12 0.21 -9999 0 -0.57 31 31
ELA2 0 0 -9999 0 -10000 0 0
PLG 0 0 -9999 0 -10000 0 0
CTGF -0.028 0.16 -9999 0 -0.64 19 19
alphaM/beta2 Integrin/Hck -0.079 0.21 -9999 0 -0.66 30 30
ITGAM -0.057 0.2 -9999 0 -0.67 28 28
alphaM/beta2 Integrin/P-Selectin/PSGL1 -0.15 0.26 -9999 0 -0.54 73 73
HP -0.18 0.3 -9999 0 -0.65 86 86
leukocyte adhesion -0.12 0.24 -9999 0 -0.78 27 27
SELP -0.14 0.29 -9999 0 -0.7 66 66
Calcium signaling in the CD4+ TCR pathway

Figure S15.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S15.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC1 -0.012 0.045 -9999 0 -0.48 1 1
NFATC2 -0.063 0.16 -9999 0 -0.51 31 31
NFATC3 -0.011 0.036 -9999 0 -10000 0 0
CD40LG -0.31 0.4 -9999 0 -0.9 70 70
PTGS2 -0.32 0.39 -9999 0 -0.83 89 89
JUNB 0.013 0 -9999 0 -10000 0 0
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.015 0.016 -9999 0 -10000 0 0
CaM/Ca2+ -0.015 0.016 -9999 0 -10000 0 0
CALM1 0.004 0.012 -9999 0 -10000 0 0
JUN 0.002 0.037 -9999 0 -0.6 1 1
mol:Ca2+ -0.014 0.014 -9999 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 -0.001 0.004 -9999 0 -10000 0 0
FOSL1 -0.046 0.2 -9999 0 -0.72 24 24
CREM 0.013 0 -9999 0 -10000 0 0
Jun/NFAT1-c-4/p21SNFT -0.17 0.21 -9999 0 -0.69 28 28
FOS -0.042 0.17 -9999 0 -0.69 20 20
IFNG -0.32 0.4 -9999 0 -0.85 87 87
AP-1/NFAT1-c-4 -0.33 0.45 -9999 0 -0.97 72 72
FASLG -0.31 0.4 -9999 0 -0.89 77 77
NFAT1-c-4/ICER1 -0.11 0.16 -9999 0 -0.55 27 27
IL2RA -0.27 0.36 -9999 0 -0.88 52 52
FKBP12/FK506 0.009 0 -9999 0 -10000 0 0
CSF2 -0.33 0.4 -9999 0 -0.84 89 89
JunB/Fra1/NFAT1-c-4 -0.13 0.18 -9999 0 -0.56 35 35
IL4 -0.26 0.34 -9999 0 -0.74 72 72
IL2 -0.009 0.033 -9999 0 -0.52 1 1
IL3 -0.031 0.069 -9999 0 -1.1 1 1
FKBP1A 0.013 0 -9999 0 -10000 0 0
BATF3 -0.001 0.097 -9999 0 -0.68 6 6
mol:FK506 0 0 -9999 0 -10000 0 0
POU2F1 0.01 0.042 -9999 0 -0.72 1 1
BCR signaling pathway

Figure S16.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S16.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
JUN -0.091 0.18 -10000 0 -0.46 34 34
IKBKB -0.038 0.091 -10000 0 -0.3 2 2
AKT1 -0.074 0.13 -10000 0 -0.28 40 40
IKBKG -0.04 0.098 -10000 0 -0.32 7 7
CALM1 -0.082 0.17 -10000 0 -0.57 20 20
PIK3CA 0.013 0 -10000 0 -10000 0 0
MAP3K1 -0.15 0.27 -10000 0 -0.59 64 64
MAP3K7 0.013 0 -10000 0 -10000 0 0
mol:Ca2+ -0.094 0.18 -10000 0 -0.57 24 24
DOK1 0.005 0.073 -10000 0 -0.72 3 3
AP-1 -0.044 0.11 -10000 0 -0.28 16 16
LYN 0.01 0.042 -10000 0 -0.72 1 1
BLNK -0.034 0.18 -10000 0 -0.72 19 19
SHC1 0.013 0 -10000 0 -10000 0 0
BCR complex -0.2 0.32 -10000 0 -0.6 109 109
CD22 -0.22 0.35 -10000 0 -0.86 53 53
CAMK2G -0.07 0.16 -10000 0 -0.53 19 19
CSNK2A1 0.013 0 -10000 0 -10000 0 0
INPP5D -0.005 0.11 -10000 0 -0.67 8 8
SHC/GRB2/SOS1 -0.16 0.23 -10000 0 -0.62 41 41
GO:0007205 -0.096 0.18 -10000 0 -0.58 24 24
SYK 0.01 0.042 -10000 0 -0.72 1 1
ELK1 -0.085 0.17 -10000 0 -0.59 19 19
NFATC1 -0.15 0.24 -10000 0 -0.53 60 60
B-cell antigen/BCR complex -0.2 0.32 -10000 0 -0.6 109 109
PAG1/CSK 0.004 0.088 -10000 0 -0.53 8 8
NFKBIB -0.004 0.033 -10000 0 -10000 0 0
HRAS -0.089 0.18 -10000 0 -0.58 21 21
NFKBIA -0.003 0.032 -10000 0 -10000 0 0
NF-kappa-B/RelA/I kappa B beta 0.004 0.027 -10000 0 -10000 0 0
RasGAP/Csk -0.18 0.27 -10000 0 -0.72 42 42
mol:GDP -0.089 0.17 -10000 0 -0.55 24 24
PTEN 0.01 0.042 -10000 0 -0.72 1 1
CD79B -0.06 0.2 -10000 0 -0.63 34 34
NF-kappa-B/RelA/I kappa B alpha 0.004 0.026 -10000 0 -10000 0 0
GRB2 0.013 0 -10000 0 -10000 0 0
PI3K/BCAP/CD19 -0.18 0.26 -10000 0 -0.6 64 64
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
mol:IP3 -0.097 0.19 -10000 0 -0.59 24 24
CSK 0.013 0 -10000 0 -10000 0 0
FOS -0.094 0.19 -10000 0 -0.58 26 26
CHUK -0.039 0.096 -10000 0 -0.3 6 6
IBTK 0.013 0 -10000 0 -10000 0 0
CARD11/BCL10/MALT1/TAK1 -0.11 0.17 -10000 0 -0.51 28 28
PTPN6 -0.2 0.32 -10000 0 -0.8 52 52
RELA 0.013 0 -10000 0 -10000 0 0
BCL2A1 0.003 0.03 -10000 0 -0.12 6 6
VAV2 -0.26 0.34 -10000 0 -0.8 65 65
ubiquitin-dependent protein catabolic process 0.001 0.032 -10000 0 -10000 0 0
BTK -0.046 0.23 0.41 3 -1.1 12 15
CD19 -0.27 0.37 -10000 0 -0.76 90 90
MAP4K1 -0.046 0.19 -10000 0 -0.68 26 26
CD72 -0.047 0.2 -10000 0 -0.68 26 26
PAG1 -0.006 0.12 -10000 0 -0.71 8 8
MAPK14 -0.12 0.23 -10000 0 -0.56 39 39
SH3BP5 0.002 0.084 -10000 0 -0.64 5 5
PIK3AP1 -0.11 0.22 -10000 0 -0.69 25 25
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 -0.15 0.28 -10000 0 -0.58 65 65
RAF1 -0.077 0.17 -10000 0 -0.55 19 19
RasGAP/p62DOK/SHIP -0.18 0.28 -10000 0 -0.74 45 45
CD79A -0.23 0.32 -10000 0 -0.66 108 108
re-entry into mitotic cell cycle -0.045 0.11 -10000 0 -0.29 16 16
RASA1 0.013 0 -10000 0 -10000 0 0
MAPK3 -0.052 0.14 -10000 0 -0.56 6 6
MAPK1 -0.052 0.14 -10000 0 -0.51 9 9
CD72/SHP1 -0.18 0.34 -10000 0 -0.83 52 52
NFKB1 0.013 0 -10000 0 -10000 0 0
MAPK8 -0.12 0.23 -10000 0 -0.57 37 37
actin cytoskeleton organization -0.19 0.29 -10000 0 -0.65 64 64
NF-kappa-B/RelA 0.014 0.051 -10000 0 -10000 0 0
Calcineurin -0.076 0.13 -10000 0 -0.52 12 12
PI3K -0.21 0.25 -10000 0 -0.61 67 67
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.11 0.2 -10000 0 -0.62 25 25
SOS1 0.013 0 -10000 0 -10000 0 0
Bam32/HPK1 -0.16 0.32 -10000 0 -0.88 38 38
DAPP1 -0.18 0.31 -10000 0 -0.95 31 31
cytokine secretion -0.14 0.22 -10000 0 -0.49 60 60
mol:DAG -0.097 0.19 -10000 0 -0.59 24 24
PLCG2 0.013 0 -10000 0 -10000 0 0
MAP2K1 -0.065 0.16 -10000 0 -0.51 18 18
B-cell antigen/BCR complex/FcgammaRIIB -0.21 0.31 -10000 0 -0.65 82 82
mol:PI-3-4-5-P3 -0.14 0.17 -10000 0 -0.4 64 64
ETS1 -0.06 0.15 -10000 0 -0.55 12 12
B-cell antigen/BCR complex/LYN/SYK/BLNK -0.18 0.27 -10000 0 -0.71 41 41
B-cell antigen/BCR complex/LYN -0.19 0.33 -10000 0 -0.8 47 47
MALT1 0.013 0 -10000 0 -10000 0 0
TRAF6 0.011 0.034 -10000 0 -0.58 1 1
RAC1 -0.2 0.32 -10000 0 -0.71 64 64
B-cell antigen/BCR complex/LYN/SYK -0.22 0.32 -10000 0 -0.82 51 51
CARD11 -0.12 0.21 -10000 0 -0.54 45 45
FCGR2B -0.032 0.17 -10000 0 -0.7 19 19
PPP3CA 0.013 0 -10000 0 -10000 0 0
BCL10 0.013 0 -10000 0 -10000 0 0
IKK complex -0.009 0.043 -10000 0 -10000 0 0
PTPRC -0.068 0.22 -10000 0 -0.68 35 35
PDPK1 -0.074 0.13 -10000 0 -0.28 35 35
PPP3CB 0.013 0 -10000 0 -10000 0 0
PPP3CC 0.013 0 -10000 0 -10000 0 0
POU2F2 0.004 0.03 -10000 0 -0.12 9 9
Syndecan-1-mediated signaling events

Figure S17.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S17.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.013 0 -9999 0 -10000 0 0
CCL5 -0.056 0.21 -9999 0 -0.68 30 30
SDCBP 0.013 0 -9999 0 -10000 0 0
FGFR/FGF2/Syndecan-1 -0.14 0.22 -9999 0 -0.61 31 31
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
RP11-540L11.1 0 0 -9999 0 -10000 0 0
Syndecan-1/Laminin-5 -0.12 0.21 -9999 0 -0.58 31 31
Syndecan-1/Syntenin -0.12 0.21 -9999 0 -0.58 31 31
MAPK3 -0.099 0.19 -9999 0 -0.61 19 19
HGF/MET -0.052 0.18 -9999 0 -0.5 41 41
TGFB1/TGF beta receptor Type II 0.013 0 -9999 0 -10000 0 0
BSG 0.013 0 -9999 0 -10000 0 0
keratinocyte migration -0.12 0.21 -9999 0 -0.57 31 31
Syndecan-1/RANTES -0.16 0.25 -9999 0 -0.59 49 49
Syndecan-1/CD147 -0.11 0.21 -9999 0 -0.65 20 20
Syndecan-1/Syntenin/PIP2 -0.12 0.2 -9999 0 -0.56 31 31
LAMA5 0.01 0.042 -9999 0 -0.72 1 1
positive regulation of cell-cell adhesion -0.14 0.18 -9999 0 -0.55 31 31
MMP7 -0.17 0.31 -9999 0 -0.67 82 82
HGF -0.064 0.22 -9999 0 -0.67 34 34
Syndecan-1/CASK -0.13 0.21 -9999 0 -0.59 31 31
Syndecan-1/HGF/MET -0.16 0.25 -9999 0 -0.67 38 38
regulation of cell adhesion -0.089 0.19 -9999 0 -0.74 9 9
HPSE 0.005 0.073 -9999 0 -0.72 3 3
positive regulation of cell migration -0.14 0.22 -9999 0 -0.61 31 31
SDC1 -0.14 0.22 -9999 0 -0.62 31 31
Syndecan-1/Collagen -0.14 0.22 -9999 0 -0.61 31 31
PPIB 0.013 0 -9999 0 -10000 0 0
MET -0.004 0.11 -9999 0 -0.72 7 7
PRKACA 0.013 0 -9999 0 -10000 0 0
MMP9 -0.057 0.2 -9999 0 -0.65 32 32
MAPK1 -0.099 0.19 -9999 0 -0.6 20 20
homophilic cell adhesion -0.13 0.22 -9999 0 -0.6 31 31
MMP1 -0.17 0.3 -9999 0 -0.67 82 82
Syndecan-2-mediated signaling events

Figure S18.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S18.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Syndecan-2/Fibronectin -0.073 0.22 -9999 0 -0.51 55 55
EPHB2 -0.048 0.2 -9999 0 -0.72 25 25
Syndecan-2/TACI -0.1 0.2 -9999 0 -0.41 85 85
LAMA1 -0.18 0.31 -9999 0 -0.68 83 83
Syndecan-2/alpha2 ITGB1 -0.016 0.15 -9999 0 -0.44 24 24
HRAS 0.011 0.034 -9999 0 -0.58 1 1
Syndecan-2/CASK -0.027 0.1 -9999 0 -0.43 19 19
ITGA5 -0.007 0.12 -9999 0 -0.72 8 8
BAX 0.01 0.11 -9999 0 -0.8 1 1
EPB41 0.013 0 -9999 0 -10000 0 0
positive regulation of cell-cell adhesion -0.024 0.094 -9999 0 -0.38 19 19
LAMA3 -0.03 0.16 -9999 0 -0.67 19 19
EZR 0.013 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
CAV2 0.001 0.091 -9999 0 -0.7 5 5
Syndecan-2/MMP2 -0.039 0.18 -9999 0 -0.51 36 36
RP11-540L11.1 0 0 -9999 0 -10000 0 0
alpha2 ITGB1 0.012 0.061 -9999 0 -0.51 4 4
dendrite morphogenesis -0.043 0.18 -9999 0 -0.47 41 41
Syndecan-2/GM-CSF -0.11 0.21 -9999 0 -0.43 91 91
determination of left/right symmetry -0.013 0.13 -9999 0 -0.5 19 19
Syndecan-2/PKC delta -0.004 0.11 -9999 0 -0.42 19 19
GNB2L1 0.013 0 -9999 0 -10000 0 0
MAPK3 -0.093 0.2 -9999 0 -0.46 42 42
MAPK1 -0.093 0.2 -9999 0 -0.46 42 42
Syndecan-2/RACK1 0.004 0.096 -9999 0 -0.4 12 12
NF1 0.013 0 -9999 0 -10000 0 0
FGFR/FGF/Syndecan-2 -0.013 0.13 -9999 0 -0.5 19 19
ITGA2 0.005 0.073 -9999 0 -0.72 3 3
MAPK8 0.002 0.12 -9999 0 -0.49 13 13
Syndecan-2/alpha2/beta1 Integrin -0.1 0.22 -9999 0 -0.45 65 65
Syndecan-2/Kininogen -0.024 0.12 -9999 0 -0.42 24 24
ITGB1 0.011 0.034 -9999 0 -0.58 1 1
SRC 0.011 0.092 -9999 0 -10000 0 0
Syndecan-2/CASK/Protein 4.1 -0.024 0.095 -9999 0 -0.39 19 19
extracellular matrix organization -0.004 0.11 -9999 0 -0.42 19 19
actin cytoskeleton reorganization -0.073 0.22 -9999 0 -0.51 55 55
Syndecan-2/Caveolin-2/Ras -0.003 0.11 -9999 0 -0.42 16 16
Syndecan-2/Laminin alpha3 -0.031 0.16 -9999 0 -0.44 36 36
Syndecan-2/RasGAP -0.022 0.084 -9999 0 -0.38 12 12
alpha5/beta1 Integrin 0.003 0.094 -9999 0 -0.53 9 9
PRKCD 0.013 0 -9999 0 -10000 0 0
Syndecan-2 dimer -0.044 0.18 -9999 0 -0.47 41 41
GO:0007205 0.003 0 -9999 0 -10000 0 0
DNA mediated transformation 0 0 -9999 0 -10000 0 0
Syndecan-2/RasGAP/Src 0.018 0.09 -9999 0 -10000 0 0
RHOA 0.013 0 -9999 0 -10000 0 0
SDCBP 0.013 0 -9999 0 -10000 0 0
TNFRSF13B -0.14 0.27 -9999 0 -0.63 69 69
RASA1 0.013 0 -9999 0 -10000 0 0
alpha2/beta1 Integrin 0.012 0.061 -9999 0 -0.51 4 4
Syndecan-2/Synbindin -0.004 0.11 -9999 0 -0.42 19 19
TGFB1 0.013 0 -9999 0 -10000 0 0
CASP3 0.006 0.1 -9999 0 -0.42 12 12
FN1 -0.098 0.25 -9999 0 -0.66 50 50
Syndecan-2/IL8 -0.077 0.19 -9999 0 -0.43 68 68
SDC2 -0.013 0.13 -9999 0 -0.5 19 19
KNG1 -0.006 0.082 -9999 0 -0.58 6 6
Syndecan-2/Neurofibromin -0.004 0.11 -9999 0 -0.42 19 19
TRAPPC4 0.013 0 -9999 0 -10000 0 0
CSF2 -0.16 0.29 -9999 0 -0.64 78 78
Syndecan-2/TGFB1 -0.004 0.11 -9999 0 -0.42 19 19
Syndecan-2/Syntenin/PI-4-5-P2 -0.024 0.095 -9999 0 -0.39 19 19
Syndecan-2/Ezrin 0.005 0.1 -9999 0 -0.42 12 12
PRKACA 0.006 0.1 -9999 0 -0.42 12 12
angiogenesis -0.077 0.19 -9999 0 -0.42 68 68
MMP2 -0.044 0.19 -9999 0 -0.67 25 25
IL8 -0.1 0.25 -9999 0 -0.66 51 51
calcineurin-NFAT signaling pathway -0.1 0.2 -9999 0 -0.41 85 85
BMP receptor signaling

Figure S19.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S19.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BMP7/BMPR2/BMPR1A-1B/FS -0.13 0.21 -9999 0 -0.76 12 12
SMAD6-7/SMURF1 -0.005 0.046 -9999 0 -0.46 3 3
NOG -0.14 0.27 -9999 0 -0.64 68 68
SMAD9 -0.056 0.15 -9999 0 -0.64 14 14
SMAD4 0.01 0.042 -9999 0 -0.72 1 1
SMAD5 -0.07 0.17 -9999 0 -0.54 21 21
BMP7/USAG1 -0.24 0.3 -9999 0 -0.54 137 137
SMAD5/SKI -0.06 0.16 -9999 0 -0.53 18 18
SMAD1 0.034 0.03 -9999 0 -10000 0 0
BMP2 -0.037 0.18 -9999 0 -0.7 21 21
SMAD1/SMAD1/SMAD4 -0.004 0.032 -9999 0 -10000 0 0
BMPR1A 0.013 0 -9999 0 -10000 0 0
BMPR1B -0.075 0.24 -9999 0 -0.72 36 36
BMPR1A-1B/BAMBI -0.09 0.19 -9999 0 -0.5 44 44
AHSG -0.035 0.16 -9999 0 -0.59 22 22
CER1 0 0 -9999 0 -10000 0 0
BMP2-4/CER1 -0.051 0.15 -9999 0 -0.48 32 32
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.1 0.2 -9999 0 -0.56 29 29
BMP2-4 (homodimer) -0.042 0.18 -9999 0 -0.56 32 32
RGMB 0.013 0 -9999 0 -10000 0 0
BMP6/BMPR2/BMPR1A-1B -0.033 0.16 -9999 0 -0.42 41 41
RGMA -0.052 0.2 -9999 0 -0.67 29 29
SMURF1 0.013 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.11 0.2 -9999 0 -0.57 32 32
BMP2-4/USAG1 -0.21 0.25 -9999 0 -0.46 136 136
SMAD6/SMURF1/SMAD5 -0.06 0.16 -9999 0 -0.53 18 18
SOSTDC1 -0.25 0.33 -9999 0 -0.66 117 117
BMP7/BMPR2/BMPR1A-1B -0.072 0.2 -9999 0 -0.45 64 64
SKI 0.013 0 -9999 0 -10000 0 0
BMP6 (homodimer) -0.007 0.12 -9999 0 -0.66 9 9
HFE2 -0.18 0.3 -9999 0 -0.66 83 83
ZFYVE16 0.013 0 -9999 0 -10000 0 0
MAP3K7 0.013 0 -9999 0 -10000 0 0
BMP2-4/CHRD -0.077 0.19 -9999 0 -0.53 39 39
SMAD5/SMAD5/SMAD4 -0.061 0.16 -9999 0 -0.53 18 18
MAPK1 0.013 0 -9999 0 -10000 0 0
TAK1/TAB family -0.1 0.16 -9999 0 -0.53 25 25
BMP7 (homodimer) -0.071 0.23 -9999 0 -0.72 35 35
NUP214 0.013 0 -9999 0 -10000 0 0
BMP6/FETUA -0.031 0.14 -9999 0 -0.46 30 30
SMAD1/SKI 0.039 0.029 -9999 0 -10000 0 0
SMAD6 0.005 0.073 -9999 0 -0.72 3 3
CTDSP2 0.013 0 -9999 0 -10000 0 0
BMP2-4/FETUA -0.076 0.18 -9999 0 -0.54 29 29
MAP3K7IP1 0 0 -9999 0 -10000 0 0
GREM1 -0.057 0.21 -9999 0 -0.67 31 31
BMPR2 (homodimer) 0.013 0 -9999 0 -10000 0 0
GADD34/PP1CA -0.002 0.029 -9999 0 -0.35 2 2
BMPR1A-1B (homodimer) -0.048 0.18 -9999 0 -0.54 36 36
CHRDL1 -0.24 0.33 -9999 0 -0.66 113 113
ENDOFIN/SMAD1 0.039 0.029 -9999 0 -10000 0 0
SMAD6-7/SMURF1/SMAD1 -0.005 0.032 -9999 0 -10000 0 0
SMAD6/SMURF1 0.013 0 -9999 0 -10000 0 0
BAMBI -0.045 0.19 -9999 0 -0.64 27 27
SMURF2 0.013 0 -9999 0 -10000 0 0
BMP2-4/CHRDL1 -0.2 0.26 -9999 0 -0.55 78 78
BMP2-4/GREM1 -0.093 0.2 -9999 0 -0.48 59 59
SMAD7 0.013 0 -9999 0 -10000 0 0
SMAD8A/SMAD8A/SMAD4 -0.046 0.15 -9999 0 -0.63 14 14
SMAD1/SMAD6 0.039 0.029 -9999 0 -10000 0 0
TAK1/SMAD6 0.019 0 -9999 0 -10000 0 0
BMP7 -0.072 0.23 -9999 0 -0.72 35 35
BMP6 -0.007 0.12 -9999 0 -0.66 9 9
MAP3K7IP2 0 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.086 0.17 -9999 0 -0.49 32 32
PPM1A 0.013 0 -9999 0 -10000 0 0
SMAD1/SMURF2 0.039 0.029 -9999 0 -10000 0 0
SMAD7/SMURF1 0.019 0 -9999 0 -10000 0 0
CTDSPL 0.013 0 -9999 0 -10000 0 0
PPP1CA 0.013 0 -9999 0 -10000 0 0
XIAP 0.013 0 -9999 0 -10000 0 0
CTDSP1 0.013 0 -9999 0 -10000 0 0
PPP1R15A 0.009 0.048 -9999 0 -0.58 2 2
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.13 0.22 -9999 0 -0.57 39 39
CHRD -0.031 0.17 -9999 0 -0.69 19 19
BMPR2 0.013 0 -9999 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM -0.12 0.21 -9999 0 -0.6 32 32
BMP4 -0.019 0.15 -9999 0 -0.72 13 13
FST -0.055 0.21 -9999 0 -0.7 29 29
BMP2-4/NOG -0.14 0.23 -9999 0 -0.46 91 91
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 -0.091 0.18 -9999 0 -0.79 5 5
Signaling events regulated by Ret tyrosine kinase

Figure S20.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S20.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.042 0.054 -9999 0 -10000 0 0
Crk/p130 Cas/Paxillin -0.1 0.14 -9999 0 -0.47 17 17
JUN -0.072 0.16 -9999 0 -0.58 8 8
HRAS 0.011 0.034 -9999 0 -0.58 1 1
RET51/GFRalpha1/GDNF/GRB10 -0.16 0.25 -9999 0 -0.52 68 68
RAP1A 0.013 0 -9999 0 -10000 0 0
FRS2 0.007 0.059 -9999 0 -0.58 3 3
RAP1A/GDP 0.009 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/DOK1 -0.16 0.25 -9999 0 -0.52 66 66
EntrezGene:5979 0 0 -9999 0 -10000 0 0
PTPN11 0.013 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.013 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/Enigma -0.11 0.2 -9999 0 -0.47 47 47
RHOA 0.013 0 -9999 0 -10000 0 0
RAP1A/GTP -0.15 0.2 -9999 0 -0.67 18 18
GRB7 -0.002 0.099 -9999 0 -0.64 7 7
RET51/GFRalpha1/GDNF -0.15 0.24 -9999 0 -0.51 65 65
MAPKKK cascade -0.13 0.18 -9999 0 -0.58 21 21
BCAR1 0.013 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/IRS1 -0.12 0.22 -9999 0 -0.5 52 52
lamellipodium assembly -0.098 0.13 -9999 0 -0.43 18 18
RET51/GFRalpha1/GDNF/SHC -0.15 0.24 -9999 0 -0.51 65 65
PIK3CA 0.013 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC -0.11 0.2 -9999 0 -0.47 47 47
RET9/GFRalpha1/GDNF/Shank3 -0.11 0.2 -9999 0 -0.47 49 49
MAPK3 -0.12 0.21 -9999 0 -0.63 18 18
DOK1 0.005 0.073 -9999 0 -0.72 3 3
DOK6 -0.043 0.19 -9999 0 -0.68 24 24
PXN 0.013 0 -9999 0 -10000 0 0
neurite development -0.11 0.2 -9999 0 -0.59 19 19
DOK5 -0.049 0.2 -9999 0 -0.68 27 27
GFRA1 -0.14 0.28 -9999 0 -0.67 68 68
MAPK8 -0.082 0.17 -9999 0 -0.54 15 15
HRAS/GTP -0.15 0.21 -9999 0 -0.67 21 21
tube development -0.098 0.19 -9999 0 -0.44 47 47
MAPK1 -0.12 0.21 -9999 0 -0.63 18 18
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.062 0.14 -9999 0 -0.33 47 47
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
SRC 0.013 0 -9999 0 -10000 0 0
PDLIM7 0.013 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok6 -0.19 0.24 -9999 0 -0.76 25 25
SHC1 0.013 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok4 -0.15 0.24 -9999 0 -0.51 65 65
RET51/GFRalpha1/GDNF/Dok5 -0.19 0.26 -9999 0 -0.54 79 79
PRKCA 0.003 0.08 -9999 0 -0.69 4 4
HRAS/GDP 0.008 0.025 -9999 0 -0.43 1 1
CREB1 -0.074 0.16 -9999 0 -0.55 11 11
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.06 0.14 -9999 0 -0.38 17 17
RET51/GFRalpha1/GDNF/Grb7 -0.16 0.25 -9999 0 -0.53 67 67
mol:GDP 0 0 -9999 0 -10000 0 0
RET -0.074 0.22 -9999 0 -0.64 40 40
DOK4 0.013 0 -9999 0 -10000 0 0
JNK cascade -0.07 0.16 -9999 0 -0.49 16 16
RET9/GFRalpha1/GDNF/FRS2 -0.11 0.2 -9999 0 -0.4 98 98
SHANK3 0.013 0 -9999 0 -10000 0 0
RASA1 0.013 0 -9999 0 -10000 0 0
NCK1 0.013 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.06 0.14 -9999 0 -0.38 17 17
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.09 0.17 -9999 0 -0.49 19 19
RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK -0.092 0.18 -9999 0 -0.58 15 15
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.091 0.18 -9999 0 -0.55 18 18
PI3K -0.11 0.24 -9999 0 -0.72 18 18
SOS1 0.013 0 -9999 0 -10000 0 0
RET9/GFRalpha1/GDNF/Shank3/Grb2 -0.12 0.18 -9999 0 -0.44 47 47
GRB10 -0.001 0.1 -9999 0 -0.7 6 6
activation of MAPKK activity -0.084 0.16 -9999 0 -0.46 21 21
RET51/GFRalpha1/GDNF/FRS2 -0.15 0.24 -9999 0 -0.51 66 66
GAB1 0.013 0 -9999 0 -10000 0 0
IRS1 -0.007 0.12 -9999 0 -0.72 8 8
IRS2 -0.002 0.099 -9999 0 -0.64 7 7
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.091 0.18 -9999 0 -0.55 18 18
RET51/GFRalpha1/GDNF/PKC alpha -0.16 0.24 -9999 0 -0.52 66 66
GRB2 0.013 0 -9999 0 -10000 0 0
PRKACA 0.013 0 -9999 0 -10000 0 0
GDNF -0.059 0.2 -9999 0 -0.61 34 34
RAC1 0.013 0 -9999 0 -10000 0 0
RET51/GFRalpha1/GDNF/IRS1 -0.16 0.25 -9999 0 -0.52 70 70
Rac1/GTP -0.12 0.16 -9999 0 -0.53 18 18
RET9/GFRalpha1/GDNF -0.14 0.21 -9999 0 -0.44 95 95
GFRalpha1/GDNF -0.15 0.25 -9999 0 -0.51 95 95
Neurotrophic factor-mediated Trk receptor signaling

Figure S21.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S21.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.011 0.034 -10000 0 -0.58 1 1
RAS family/GTP/Tiam1 -0.042 0.11 -10000 0 -0.36 4 4
NT3 (dimer)/TRKC -0.16 0.26 -10000 0 -0.52 100 100
NT3 (dimer)/TRKB -0.31 0.31 -10000 0 -0.54 175 175
SHC/Grb2/SOS1/GAB1/PI3K 0.034 0.023 -10000 0 -10000 0 0
RAPGEF1 0.013 0 -10000 0 -10000 0 0
BDNF -0.1 0.25 -10000 0 -0.65 53 53
PIK3CA 0.013 0 -10000 0 -10000 0 0
DYNLT1 0.013 0 -10000 0 -10000 0 0
NTRK1 -0.024 0.15 -10000 0 -0.67 16 16
NTRK2 -0.3 0.33 -10000 0 -0.64 142 142
NTRK3 -0.097 0.25 -10000 0 -0.66 49 49
NT-4/5 (dimer)/TRKB -0.24 0.26 -10000 0 -0.46 156 156
neuron apoptosis 0.19 0.19 0.54 46 -10000 0 46
SHC 2-3/Grb2 -0.19 0.23 -10000 0 -0.6 46 46
SHC1 0.013 0 -10000 0 -10000 0 0
SHC2 -0.17 0.21 -10000 0 -0.6 42 42
SHC3 -0.18 0.22 -10000 0 -0.6 43 43
STAT3 (dimer) 0.001 0.078 -10000 0 -0.37 6 6
NT3 (dimer)/TRKA -0.15 0.24 -10000 0 -0.48 94 94
RIN/GDP -0.037 0.088 -10000 0 -0.28 1 1
GIPC1 0.013 0 -10000 0 -10000 0 0
KRAS 0.013 0 -10000 0 -10000 0 0
DNAJA3 -0.093 0.17 0.27 5 -0.52 23 28
RIN/GTP 0 0 -10000 0 -10000 0 0
CCND1 -0.013 0.18 -10000 0 -0.66 19 19
MAGED1 -0.007 0.12 -10000 0 -0.72 8 8
PTPN11 0.013 0 -10000 0 -10000 0 0
RICS 0 0 -10000 0 -10000 0 0
NT-4/5 (dimer) 0.003 0.08 -10000 0 -0.69 4 4
SHC/GRB2/SOS1 0 0 -10000 0 -10000 0 0
GRB2 0.013 0 -10000 0 -10000 0 0
NGF (dimer)/TRKA/MATK -0.15 0.22 -10000 0 -0.51 62 62
TRKA/NEDD4-2 -0.008 0.12 -10000 0 -0.5 16 16
ELMO1 0.005 0.073 -10000 0 -0.72 3 3
RhoG/GTP/ELMO1/DOCK1 -0.005 0.047 -10000 0 -0.47 3 3
NGF -0.13 0.28 -10000 0 -0.68 64 64
HRAS 0.011 0.034 -10000 0 -0.58 1 1
DOCK1 0.013 0 -10000 0 -10000 0 0
GAB2 0.008 0.06 -10000 0 -0.72 2 2
RIT2 0 0 -10000 0 -10000 0 0
RIT1 0.01 0.042 -10000 0 -0.72 1 1
FRS2 0.007 0.059 -10000 0 -0.58 3 3
DNM1 -0.023 0.16 -10000 0 -0.71 15 15
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.013 0 -10000 0 -10000 0 0
SH2B1 (homopentamer) 0 0 -10000 0 -10000 0 0
RhoG/GTP -0.094 0.17 0.26 5 -0.52 25 30
mol:GDP -0.055 0.13 -10000 0 -0.4 2 2
NGF (dimer) -0.13 0.28 -10000 0 -0.68 64 64
RhoG/GDP 0.004 0.056 -10000 0 -0.55 3 3
RIT1/GDP -0.033 0.091 -10000 0 -0.32 2 2
TIAM1 0.005 0.073 -10000 0 -0.72 3 3
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
BDNF (dimer)/TRKB -0.26 0.26 -10000 0 -0.48 163 163
KIDINS220/CRKL/C3G 0.017 0.025 -10000 0 -0.42 1 1
SHC/RasGAP 0.019 0 -10000 0 -10000 0 0
FRS2 family/SHP2 -0.003 0.035 -10000 0 -0.35 3 3
SHC/GRB2/SOS1/GAB1 0.033 0 -10000 0 -10000 0 0
RIT1/GTP 0.008 0.032 -10000 0 -0.55 1 1
NT3 (dimer) -0.12 0.27 -10000 0 -0.65 60 60
RAP1/GDP -0.046 0.06 -10000 0 -10000 0 0
KIDINS220/CRKL 0.011 0.034 -10000 0 -0.58 1 1
BDNF (dimer) -0.1 0.25 -10000 0 -0.65 53 53
ubiquitin-dependent protein catabolic process -0.11 0.19 -10000 0 -0.47 53 53
Schwann cell development -0.053 0.036 -10000 0 -10000 0 0
EHD4 0.013 0 -10000 0 -10000 0 0
FRS2 family/GRB2/SOS1 0.029 0.034 -10000 0 -10000 0 0
FRS2 family/SHP2/CRK family/C3G/GAB2 0.035 0.031 -10000 0 -10000 0 0
RAP1B 0.009 0.048 -10000 0 -0.58 2 2
RAP1A 0.013 0 -10000 0 -10000 0 0
CDC42/GTP -0.32 0.28 -10000 0 -0.69 87 87
ABL1 0.013 0 -10000 0 -10000 0 0
SH2B family/GRB2/SOS1 0.019 0 -10000 0 -10000 0 0
Rap1/GTP -0.086 0.087 -10000 0 -0.46 1 1
STAT3 0.001 0.077 -10000 0 -0.37 6 6
axon guidance -0.3 0.26 -10000 0 -0.65 87 87
MAPK3 -0.11 0.22 -10000 0 -0.46 62 62
MAPK1 -0.11 0.22 -10000 0 -0.46 62 62
CDC42/GDP -0.032 0.089 -10000 0 -10000 0 0
NTF3 -0.12 0.27 -10000 0 -0.65 60 60
NTF4 0.003 0.08 -10000 0 -0.69 4 4
NGF (dimer)/TRKA/FAIM -0.11 0.19 -10000 0 -0.47 53 53
PI3K 0.016 0.041 -10000 0 -0.48 2 2
FRS3 0.013 0 -10000 0 -10000 0 0
FAIM 0.013 0 -10000 0 -10000 0 0
GAB1 0.013 0 -10000 0 -10000 0 0
RASGRF1 -0.13 0.2 0.27 4 -0.53 38 42
SOS1 0.013 0 -10000 0 -10000 0 0
MCF2L -0.16 0.25 -10000 0 -0.46 116 116
RGS19 0.013 0 -10000 0 -10000 0 0
CDC42 0.013 0 -10000 0 -10000 0 0
RAS family/GTP 0.006 0.076 -10000 0 -10000 0 0
Rac1/GDP -0.032 0.089 -10000 0 -0.27 1 1
NGF (dimer)/TRKA/GRIT -0.12 0.2 -10000 0 -0.44 79 79
neuron projection morphogenesis -0.066 0.17 -10000 0 -0.57 13 13
NGF (dimer)/TRKA/NEDD4-2 -0.11 0.19 -10000 0 -0.47 53 53
MAP2K1 0.038 0 -10000 0 -10000 0 0
NGFR -0.063 0.21 -10000 0 -0.66 34 34
NGF (dimer)/TRKA/GIPC/GAIP -0.057 0.16 -10000 0 -0.6 6 6
RAS family/GTP/PI3K 0.028 0.026 -10000 0 -0.3 1 1
FRS2 family/SHP2/GRB2/SOS1 -0.003 0.029 -10000 0 -10000 0 0
NRAS 0.013 0 -10000 0 -10000 0 0
GRB2/SOS1 0.019 0 -10000 0 -10000 0 0
PRKCI 0.013 0 -10000 0 -10000 0 0
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
RAC1 0.013 0 -10000 0 -10000 0 0
PRKCZ 0.01 0.042 -10000 0 -0.72 1 1
MAPKKK cascade -0.16 0.26 -10000 0 -0.68 53 53
RASA1 0.013 0 -10000 0 -10000 0 0
TRKA/c-Abl -0.008 0.12 -10000 0 -0.5 16 16
SQSTM1 0.01 0.042 -10000 0 -0.72 1 1
BDNF (dimer)/TRKB/GIPC -0.22 0.25 -10000 0 -0.5 103 103
NGF (dimer)/TRKA/p62/Atypical PKCs -0.097 0.16 -10000 0 -0.79 1 1
MATK -0.043 0.18 -10000 0 -0.63 26 26
NEDD4L 0.013 0 -10000 0 -10000 0 0
RAS family/GDP -0.041 0.055 -10000 0 -10000 0 0
NGF (dimer)/TRKA -0.1 0.18 0.29 5 -0.39 62 67
Rac1/GTP -0.098 0.12 -10000 0 -0.37 21 21
FRS2 family/SHP2/CRK family -0.004 0.033 -10000 0 -10000 0 0
Visual signal transduction: Rods

Figure S22.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S22.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:K + 0.013 0 -9999 0 -10000 0 0
GNAT1/GTP -0.002 0.056 -9999 0 -0.43 5 5
Metarhodopsin II/Arrestin -0.007 0.051 -9999 0 -0.37 6 6
PDE6G/GNAT1/GTP -0.023 0.094 -9999 0 -0.4 17 17
mol:GTP 0 0 -9999 0 -10000 0 0
absorption of light 0 0 -9999 0 -10000 0 0
GNAT1 -0.003 0.076 -9999 0 -0.58 5 5
GRK1 0 0 -9999 0 -10000 0 0
CNG Channel -0.25 0.28 -9999 0 -0.72 61 61
mol:Na + -0.24 0.27 -9999 0 -0.74 44 44
mol:ADP 0 0 -9999 0 -10000 0 0
RGS9-1/Gbeta5/R9AP -0.037 0.12 -9999 0 -0.42 27 27
mol:GDP 0 0 -9999 0 -10000 0 0
cGMP/CNG Channel -0.25 0.28 -9999 0 -0.78 44 44
CNGB1 -0.25 0.34 -9999 0 -0.68 113 113
RDH5 -0.002 0.093 -9999 0 -0.6 7 7
SAG 0 0 -9999 0 -10000 0 0
mol:Ca2+ -0.21 0.27 -9999 0 -0.71 44 44
Na + (4 Units) -0.22 0.24 -9999 0 -0.68 44 44
RGS9 -0.012 0.13 -9999 0 -0.66 11 11
GNB1/GNGT1 -0.024 0.14 -9999 0 -0.51 24 24
GNAT1/GDP -0.036 0.11 -9999 0 -0.42 17 17
GUCY2D -0.079 0.23 -9999 0 -0.66 41 41
GNGT1 -0.044 0.19 -9999 0 -0.68 24 24
GUCY2F 0 0 -9999 0 -10000 0 0
GNB5 0.013 0 -9999 0 -10000 0 0
mol:GMP (4 units) -0.092 0.21 -9999 0 -0.52 39 39
mol:11-cis-retinal -0.002 0.093 -9999 0 -0.6 7 7
mol:cGMP -0.094 0.21 -9999 0 -0.47 54 54
GNB1 0.013 0 -9999 0 -10000 0 0
Rhodopsin -0.007 0.091 -9999 0 -0.43 13 13
SLC24A1 0.013 0 -9999 0 -10000 0 0
CNGA1 -0.033 0.17 -9999 0 -0.68 20 20
Metarhodopsin II -0.004 0.047 -9999 0 -0.34 6 6
mol:Ca ++ 0 0 -9999 0 -10000 0 0
GC1/GCAP Family -0.1 0.22 -9999 0 -0.5 54 54
RGS9BP -0.023 0.15 -9999 0 -0.66 16 16
Metarhodopsin II/Transducin -0.015 0.09 -9999 0 -0.32 18 18
GCAP Family/Ca ++ -0.053 0.18 -9999 0 -0.44 48 48
PDE6A/B -0.11 0.24 -9999 0 -0.51 76 76
mol:Pi -0.037 0.12 -9999 0 -0.41 27 27
mol:all-trans-retinal 0 0 -9999 0 -10000 0 0
Transducin -0.019 0.12 -9999 0 -0.39 29 29
PDE6B -0.1 0.25 -9999 0 -0.64 52 52
PDE6A -0.055 0.2 -9999 0 -0.62 32 32
PDE6G -0.014 0.13 -9999 0 -0.66 12 12
RHO -0.008 0.082 -9999 0 -0.58 6 6
PDE6 -0.13 0.2 -9999 0 -0.66 22 22
GUCA1A -0.056 0.21 -9999 0 -0.68 30 30
GC2/GCAP Family -0.053 0.18 -9999 0 -0.44 48 48
GUCA1C -0.01 0.095 -9999 0 -0.58 8 8
GUCA1B -0.026 0.16 -9999 0 -0.72 16 16
Glypican 1 network

Figure S23.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S23.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GPC1/FGF2 dimer/FGFR1 dimer -0.061 0.17 -10000 0 -0.45 41 41
fibroblast growth factor receptor signaling pathway -0.061 0.17 -10000 0 -0.45 41 41
LAMA1 -0.18 0.31 -10000 0 -0.68 83 83
PRNP 0.01 0.042 -10000 0 -0.72 1 1
GPC1/SLIT2 -0.059 0.19 -10000 0 -0.5 45 45
SMAD2 0.022 0.066 -10000 0 -0.42 6 6
GPC1/PrPc/Cu2+ -0.003 0.034 -10000 0 -0.42 2 2
GPC1/Laminin alpha1 -0.13 0.24 -10000 0 -0.51 83 83
TDGF1 -0.014 0.11 -10000 0 -0.58 11 11
CRIPTO/GPC1 -0.002 0.086 -10000 0 -0.42 12 12
APP/GPC1 0.017 0.025 -10000 0 -0.42 1 1
mol:NO 0 0 -10000 0 -10000 0 0
YES1 0.009 0.073 -10000 0 -0.35 12 12
FLT1 0.008 0.06 -10000 0 -0.72 2 2
GPC1/TGFB/TGFBR1/TGFBR2 -0.01 0.068 -10000 0 -0.46 6 6
SERPINC1 0.002 0.076 -10000 0 -0.58 5 5
FYN 0.004 0.086 -10000 0 -0.37 15 15
FGR -0.009 0.11 -10000 0 -0.38 24 24
positive regulation of MAPKKK cascade -0.046 0.15 -10000 0 -0.56 9 9
SLIT2 -0.088 0.24 -10000 0 -0.68 44 44
GPC1/NRG -0.038 0.16 -10000 0 -0.5 33 33
NRG1 -0.06 0.21 -10000 0 -0.68 32 32
GPC1/VEGF165 homodimer/VEGFR1 homodimer -0.005 0.047 -10000 0 -0.46 2 2
LYN 0.007 0.078 -10000 0 -0.47 1 1
mol:Spermine 0.01 0.025 -10000 0 -0.43 1 1
cell growth -0.061 0.17 -10000 0 -0.45 41 41
BMP signaling pathway -0.011 0.034 0.58 1 -10000 0 1
SRC 0.009 0.073 -10000 0 -0.35 12 12
TGFBR1 0.013 0 -10000 0 -10000 0 0
mol:Cu2+ 0 0 -10000 0 -10000 0 0
PLA2G2A -0.26 0.33 -10000 0 -0.65 123 123
GPC1 0.011 0.034 -10000 0 -0.58 1 1
TGFBR1 (dimer) 0.013 0 -10000 0 -10000 0 0
VEGFA 0.011 0.034 -10000 0 -0.58 1 1
BLK -0.11 0.21 -10000 0 -0.43 91 91
HCK -0.004 0.11 -10000 0 -0.41 19 19
FGF2 -0.062 0.21 -10000 0 -0.64 35 35
FGFR1 -0.012 0.13 -10000 0 -0.67 11 11
VEGFR1 homodimer 0.008 0.06 -10000 0 -0.72 2 2
TGFBR2 -0.002 0.1 -10000 0 -0.72 6 6
cell death 0.017 0.025 -10000 0 -0.42 1 1
ATIII/GPC1 0.009 0.061 -10000 0 -0.42 6 6
PLA2G2A/GPC1 -0.18 0.25 -10000 0 -0.48 123 123
LCK -0.021 0.13 -10000 0 -0.46 14 14
neuron differentiation -0.038 0.16 -10000 0 -0.5 33 33
PrPc/Cu2+ 0.008 0.032 -10000 0 -0.55 1 1
APP 0.013 0 -10000 0 -10000 0 0
TGFBR2 (dimer) -0.002 0.1 -10000 0 -0.72 6 6
Signaling events mediated by the Hedgehog family

Figure S24.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S24.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB2 -0.076 0.3 -10000 0 -1.1 15 15
IHH -0.008 0.074 -10000 0 -0.63 2 2
SHH Np/Cholesterol/GAS1 -0.037 0.15 -10000 0 -0.53 11 11
LRPAP1 0.013 0 -10000 0 -10000 0 0
dorsoventral neural tube patterning 0.036 0.14 0.53 11 -10000 0 11
SMO/beta Arrestin2 -0.045 0.19 -10000 0 -0.67 11 11
SMO -0.054 0.2 -10000 0 -0.71 11 11
AKT1 -0.004 0.091 -10000 0 -10000 0 0
ARRB2 0.013 0 -10000 0 -10000 0 0
BOC -0.008 0.12 -10000 0 -0.69 9 9
ADRBK1 0.013 0 -10000 0 -10000 0 0
heart looping -0.052 0.19 -10000 0 -0.69 11 11
STIL -0.044 0.17 -10000 0 -0.63 10 10
DHH N/PTCH2 -0.056 0.18 -10000 0 -0.5 43 43
DHH N/PTCH1 -0.057 0.2 -10000 0 -0.57 21 21
PIK3CA 0.013 0 -10000 0 -10000 0 0
DHH -0.043 0.19 -10000 0 -0.68 24 24
PTHLH -0.14 0.44 -10000 0 -1.2 42 42
determination of left/right symmetry -0.052 0.19 -10000 0 -0.69 11 11
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
skeletal system development -0.14 0.43 -10000 0 -1.1 42 42
IHH N/Hhip -0.1 0.22 -10000 0 -0.52 66 66
DHH N/Hhip -0.13 0.24 -10000 0 -0.51 82 82
mol:Cholesterol 0 0 -10000 0 -10000 0 0
heart development -0.052 0.19 -10000 0 -0.69 11 11
pancreas development -0.13 0.27 -10000 0 -0.64 64 64
HHAT 0.008 0.054 -10000 0 -0.66 2 2
PI3K 0.016 0.041 -10000 0 -0.48 2 2
EntrezGene:84976 0 0 -10000 0 -10000 0 0
GAS1 -0.013 0.13 -10000 0 -0.7 11 11
somite specification -0.052 0.19 -10000 0 -0.69 11 11
SHH Np/Cholesterol/PTCH1 -0.053 0.18 -10000 0 -0.67 9 9
SHH Np/Cholesterol/PTCH2 -0.046 0.17 -10000 0 -0.57 18 18
SHH Np/Cholesterol/Megalin -0.047 0.16 -10000 0 -0.55 13 13
SHH -0.036 0.15 -10000 0 -0.44 36 36
catabolic process -0.033 0.18 -10000 0 -0.58 16 16
SMO/Vitamin D3 -0.06 0.19 -10000 0 -0.61 14 14
SHH Np/Cholesterol/Hhip -0.1 0.2 -10000 0 -0.43 67 67
LRP2 -0.029 0.16 -10000 0 -0.63 19 19
receptor-mediated endocytosis -0.094 0.17 -10000 0 -0.67 10 10
SHH Np/Cholesterol/BOC -0.034 0.14 -10000 0 -0.47 10 10
SHH Np/Cholesterol/CDO -0.036 0.14 -10000 0 -0.35 47 47
mesenchymal cell differentiation 0.1 0.2 0.41 86 -10000 0 86
mol:Vitamin D3 -0.051 0.18 -10000 0 -0.68 9 9
IHH N/PTCH2 -0.027 0.14 -10000 0 -0.5 22 22
CDON -0.013 0.13 -10000 0 -0.63 12 12
IHH N/PTCH1 -0.033 0.18 -10000 0 -0.58 16 16
Megalin/LRPAP1 -0.013 0.12 -10000 0 -0.46 19 19
PTCH2 -0.031 0.16 -10000 0 -0.62 21 21
SHH Np/Cholesterol -0.038 0.11 -10000 0 -0.34 36 36
PTCH1 -0.033 0.18 -10000 0 -0.58 16 16
HHIP -0.13 0.27 -10000 0 -0.64 64 64
Noncanonical Wnt signaling pathway

Figure S25.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S25.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC2 -0.06 0.22 -9999 0 -0.7 31 31
GNB1/GNG2 -0.1 0.24 -9999 0 -0.74 25 25
mol:DAG -0.085 0.21 -9999 0 -0.74 18 18
PLCG1 -0.089 0.22 -9999 0 -0.78 18 18
YES1 -0.11 0.24 -9999 0 -0.74 24 24
FZD3 -0.021 0.15 -9999 0 -0.71 14 14
FZD6 0.013 0 -9999 0 -10000 0 0
G protein -0.09 0.23 -9999 0 -0.8 18 18
MAP3K7 -0.14 0.22 -9999 0 -0.62 29 29
mol:Ca2+ -0.081 0.2 -9999 0 -0.7 18 18
mol:IP3 -0.085 0.21 -9999 0 -0.74 18 18
NLK -0.009 0.011 -9999 0 -10000 0 0
GNB1 0.013 0 -9999 0 -10000 0 0
CAMK2A -0.16 0.25 -9999 0 -0.68 32 32
MAP3K7IP1 0 0 -9999 0 -10000 0 0
Noncanonical Wnts/FZD -0.12 0.25 -9999 0 -0.72 29 29
CSNK1A1 0.013 0 -9999 0 -10000 0 0
GNAS -0.11 0.24 -9999 0 -0.74 24 24
GO:0007205 -0.083 0.21 -9999 0 -0.72 18 18
WNT6 -0.077 0.23 -9999 0 -0.65 41 41
WNT4 -0.048 0.2 -9999 0 -0.67 27 27
NFAT1/CK1 alpha -0.11 0.25 -9999 0 -0.72 30 30
GNG2 0.001 0.091 -9999 0 -0.7 5 5
WNT5A -0.023 0.16 -9999 0 -0.71 15 15
WNT11 -0.13 0.27 -9999 0 -0.64 68 68
CDC42 -0.094 0.22 -9999 0 -0.69 24 24
FOXA2 and FOXA3 transcription factor networks

Figure S26.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S26.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ACADVL -0.18 0.34 -10000 0 -1 21 21
PCK1 -0.14 0.25 -10000 0 -0.8 16 16
HNF4A -0.22 0.38 -10000 0 -1.1 27 27
KCNJ11 -0.3 0.49 -10000 0 -1.2 48 48
AKT1 -0.036 0.13 -10000 0 -10000 0 0
response to starvation -0.002 0.018 -10000 0 -10000 0 0
DLK1 -0.26 0.43 -10000 0 -1.1 35 35
NKX2-1 -0.016 0.27 0.57 3 -0.75 13 16
ACADM -0.19 0.34 -10000 0 -0.99 23 23
TAT -0.11 0.2 -10000 0 -0.86 4 4
CEBPB 0.013 0 -10000 0 -10000 0 0
CEBPA -0.004 0.11 -10000 0 -0.72 7 7
TTR -0.22 0.27 -10000 0 -0.66 53 53
PKLR -0.22 0.38 -10000 0 -1 31 31
APOA1 -0.21 0.38 -10000 0 -1.1 23 23
CPT1C -0.19 0.36 -10000 0 -1 26 26
ALAS1 -0.066 0.17 -10000 0 -10000 0 0
TFRC -0.16 0.28 -10000 0 -1.1 7 7
FOXF1 -0.012 0.14 -10000 0 -0.65 12 12
NF1 0.02 0 -10000 0 -10000 0 0
HNF1A (dimer) -0.012 0.1 -10000 0 -0.6 8 8
CPT1A -0.19 0.34 -10000 0 -0.98 23 23
HMGCS1 -0.19 0.34 -10000 0 -1 20 20
NR3C1 0.018 0.021 -10000 0 -10000 0 0
CPT1B -0.21 0.39 -10000 0 -1.1 29 29
chromatin remodeling 0 0 -10000 0 -10000 0 0
SP1 0.004 0.04 -10000 0 -10000 0 0
GCK -0.25 0.43 -10000 0 -1.1 42 42
CREB1 0.008 0.029 -10000 0 -10000 0 0
IGFBP1 -0.074 0.18 -10000 0 -0.75 5 5
PDX1 -0.14 0.31 -10000 0 -1 19 19
UCP2 -0.2 0.38 -10000 0 -1.1 27 27
ALDOB -0.21 0.38 -10000 0 -1 27 27
AFP -0.17 0.24 -10000 0 -0.69 29 29
BDH1 -0.19 0.35 -10000 0 -1 24 24
HADH -0.2 0.36 -10000 0 -1.1 20 20
F2 -0.22 0.39 -10000 0 -1.1 25 25
HNF1A -0.012 0.1 -10000 0 -0.6 8 8
G6PC -0.038 0.12 -10000 0 -0.4 10 10
SLC2A2 -0.12 0.22 -10000 0 -0.52 27 27
INS -0.009 0.021 -10000 0 -10000 0 0
FOXA1 -0.25 0.33 -10000 0 -0.66 116 116
FOXA3 -0.11 0.26 -10000 0 -0.67 51 51
FOXA2 -0.23 0.41 -10000 0 -1.1 34 34
ABCC8 -0.21 0.37 -10000 0 -1.1 23 23
ALB -0.2 0.26 -10000 0 -0.74 33 33
Syndecan-4-mediated signaling events

Figure S27.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S27.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.059 0.19 -9999 0 -0.62 26 26
Syndecan-4/Syndesmos -0.068 0.2 -9999 0 -0.67 18 18
positive regulation of JNK cascade -0.11 0.24 -9999 0 -0.69 31 31
Syndecan-4/ADAM12 -0.098 0.25 -9999 0 -0.69 34 34
CCL5 -0.056 0.21 -9999 0 -0.68 30 30
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
DNM2 0.013 0 -9999 0 -10000 0 0
ITGA5 -0.007 0.12 -9999 0 -0.72 8 8
SDCBP 0.013 0 -9999 0 -10000 0 0
PLG 0 0.008 -9999 0 -10000 0 0
ADAM12 -0.049 0.2 -9999 0 -0.68 27 27
mol:GTP 0 0 -9999 0 -10000 0 0
NUDT16L1 0.013 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
Syndecan-4/PKC alpha -0.025 0.043 -9999 0 -0.14 19 19
Syndecan-4/Laminin alpha1 -0.16 0.27 -9999 0 -0.74 36 36
Syndecan-4/CXCL12/CXCR4 -0.12 0.26 -9999 0 -0.75 31 31
Syndecan-4/Laminin alpha3 -0.089 0.22 -9999 0 -0.66 25 25
MDK -0.012 0.13 -9999 0 -0.67 11 11
Syndecan-4/FZD7 -0.09 0.22 -9999 0 -0.68 22 22
Syndecan-4/Midkine -0.08 0.21 -9999 0 -0.68 22 22
FZD7 -0.031 0.16 -9999 0 -0.62 21 21
Syndecan-4/FGFR1/FGF -0.13 0.22 -9999 0 -0.68 31 31
THBS1 -0.033 0.17 -9999 0 -0.68 20 20
integrin-mediated signaling pathway -0.11 0.23 -9999 0 -0.67 29 29
positive regulation of MAPKKK cascade -0.11 0.24 -9999 0 -0.69 31 31
Syndecan-4/TACI -0.14 0.24 -9999 0 -0.67 31 31
CXCR4 -0.034 0.17 -9999 0 -0.66 21 21
cell adhesion -0.038 0.17 -9999 0 -0.49 27 27
Syndecan-4/Dynamin -0.068 0.2 -9999 0 -0.67 18 18
Syndecan-4/TSP1 -0.091 0.23 -9999 0 -0.67 30 30
Syndecan-4/GIPC -0.068 0.2 -9999 0 -0.67 18 18
Syndecan-4/RANTES -0.1 0.24 -9999 0 -0.72 25 25
ITGB1 0.011 0.034 -9999 0 -0.58 1 1
LAMA1 -0.18 0.31 -9999 0 -0.68 83 83
LAMA3 -0.03 0.16 -9999 0 -0.67 19 19
RAC1 0.013 0 -9999 0 -10000 0 0
PRKCA 0.018 0.084 -9999 0 -0.6 4 4
Syndecan-4/alpha-Actinin -0.073 0.21 -9999 0 -0.69 19 19
TFPI 0.002 0.084 -9999 0 -0.64 5 5
F2 -0.039 0.16 -9999 0 -0.59 23 23
alpha5/beta1 Integrin 0.003 0.094 -9999 0 -0.53 9 9
positive regulation of cell adhesion -0.17 0.28 -9999 0 -0.72 40 40
ACTN1 0.003 0.084 -9999 0 -0.72 4 4
TNC -0.077 0.24 -9999 0 -0.72 37 37
Syndecan-4/CXCL12 -0.11 0.25 -9999 0 -0.7 31 31
FGF6 0 0 -9999 0 -10000 0 0
RHOA 0.013 0 -9999 0 -10000 0 0
CXCL12 -0.066 0.22 -9999 0 -0.67 35 35
TNFRSF13B -0.14 0.27 -9999 0 -0.63 69 69
FGF2 -0.062 0.21 -9999 0 -0.64 35 35
FGFR1 -0.012 0.13 -9999 0 -0.67 11 11
Syndecan-4/PI-4-5-P2 -0.076 0.2 -9999 0 -0.64 21 21
mol:GDP 0 0 -9999 0 -10000 0 0
FN1 -0.096 0.25 -9999 0 -0.65 50 50
cell migration -0.007 0.014 -9999 0 -10000 0 0
PRKCD 0.014 0.009 -9999 0 -10000 0 0
vasculogenesis -0.086 0.22 -9999 0 -0.63 30 30
SDC4 -0.079 0.21 -9999 0 -0.72 18 18
Syndecan-4/Tenascin C -0.11 0.25 -9999 0 -0.71 29 29
Syndecan-4/PI-4-5-P2/PKC alpha -0.02 0.034 -9999 0 -0.11 19 19
Syndecan-4/Syntenin -0.068 0.2 -9999 0 -0.67 18 18
MMP9 -0.056 0.2 -9999 0 -0.65 32 32
Rac1/GTP -0.04 0.17 -9999 0 -0.51 27 27
cytoskeleton organization -0.065 0.19 -9999 0 -0.64 18 18
GIPC1 0.013 0 -9999 0 -10000 0 0
Syndecan-4/TFPI -0.073 0.21 -9999 0 -0.69 19 19
Class IB PI3K non-lipid kinase events

Figure S28.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S28.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
cAMP biosynthetic process 0.034 0.17 0.69 20 -10000 0 20
PI3K Class IB/PDE3B -0.034 0.18 -10000 0 -0.69 20 20
PDE3B -0.034 0.18 -10000 0 -0.69 20 20
LPA4-mediated signaling events

Figure S29.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S29.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ADCY4 0.012 0.056 -9999 0 -0.47 4 4
ADCY5 -0.078 0.18 -9999 0 -0.42 67 67
ADCY6 0.003 0.088 -9999 0 -0.47 10 10
ADCY7 0.016 0.04 -9999 0 -0.47 2 2
ADCY1 -0.01 0.11 -9999 0 -0.42 20 20
ADCY2 -0.12 0.2 -9999 0 -0.41 94 94
ADCY3 0.019 0 -9999 0 -10000 0 0
ADCY8 -0.01 0.089 -9999 0 -0.36 18 18
PRKCE 0.011 0 -9999 0 -10000 0 0
ADCY9 0.019 0 -9999 0 -10000 0 0
mol:DAG 0 0 -9999 0 -10000 0 0
cAMP biosynthetic process -0.063 0.12 -9999 0 -0.44 13 13
Glucocorticoid receptor regulatory network

Figure S30.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S30.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PCK2 0.032 0.092 -10000 0 -10000 0 0
SMARCC2 0.014 0.004 -10000 0 -10000 0 0
SMARCC1 0.014 0.004 -10000 0 -10000 0 0
TBX21 -0.16 0.36 -10000 0 -0.95 45 45
SUMO2 0.014 0.007 -10000 0 -10000 0 0
STAT1 (dimer) 0.01 0.088 -10000 0 -0.64 5 5
FKBP4 0.013 0 -10000 0 -10000 0 0
FKBP5 -0.005 0.11 -10000 0 -0.66 8 8
GR alpha/HSP90/FKBP51/HSP90 0.089 0.13 0.38 14 -0.42 2 16
PRL -0.1 0.18 -10000 0 -0.77 6 6
cortisol/GR alpha (dimer)/TIF2 0.22 0.27 0.61 67 -0.5 1 68
RELA -0.028 0.094 -10000 0 -0.31 1 1
FGG 0.15 0.26 0.56 37 -0.56 13 50
GR beta/TIF2 0.1 0.14 0.4 19 -0.5 4 23
IFNG -0.34 0.52 -10000 0 -1.2 69 69
apoptosis 0.036 0.17 0.51 8 -0.68 1 9
CREB1 0.011 0.035 -10000 0 -10000 0 0
histone acetylation -0.005 0.15 0.38 9 -0.44 12 21
BGLAP -0.063 0.15 -10000 0 -0.57 8 8
GR/PKAc 0.089 0.13 0.35 18 -0.41 5 23
NF kappa B1 p50/RelA -0.053 0.17 -10000 0 -0.5 9 9
SMARCD1 0.014 0.004 -10000 0 -10000 0 0
MDM2 0.088 0.11 0.3 33 -0.24 1 34
GATA3 -0.021 0.15 -10000 0 -0.68 15 15
AKT1 0 0.001 -10000 0 -10000 0 0
CSF2 -0.22 0.42 -10000 0 -1.3 33 33
GSK3B 0.014 0.007 -10000 0 -10000 0 0
NR1I3 0.06 0.18 0.52 5 -0.88 3 8
CSN2 0.14 0.17 0.4 53 -10000 0 53
BRG1/BAF155/BAF170/BAF60A 0.038 0.015 -10000 0 -10000 0 0
NFATC1 0.01 0.042 -10000 0 -0.72 1 1
POU2F1 0.011 0.045 -10000 0 -0.72 1 1
CDKN1A -0.004 0.14 -10000 0 -1.6 1 1
response to stress 0 0 -10000 0 -10000 0 0
response to UV 0.002 0.008 -10000 0 -10000 0 0
SFN -0.004 0.11 -10000 0 -0.7 7 7
GR alpha/HSP90/FKBP51/HSP90/14-3-3 0.083 0.14 0.37 12 -0.46 1 13
prolactin receptor activity 0 0 -10000 0 -10000 0 0
EGR1 0.055 0.18 0.5 5 -0.92 3 8
JUN -0.14 0.22 -10000 0 -0.63 28 28
IL4 -0.085 0.15 -10000 0 -0.4 39 39
CDK5R1 0.002 0.091 -10000 0 -0.7 5 5
PRKACA 0.013 0 -10000 0 -10000 0 0
cortisol/GR alpha (monomer)/AP-1 -0.087 0.23 0.25 10 -0.63 26 36
GR alpha/HSP90/FKBP51/HSP90/PP5C 0.094 0.12 0.38 11 -10000 0 11
cortisol/GR alpha (monomer) 0.26 0.34 0.76 69 -10000 0 69
NCOA2 0.001 0.094 -10000 0 -0.72 5 5
response to hypoxia 0 0 -10000 0 -10000 0 0
FOS -0.064 0.19 -10000 0 -0.73 20 20
AP-1/NFAT1-c-4 -0.23 0.34 -10000 0 -0.84 47 47
AFP -0.11 0.2 -10000 0 -0.76 13 13
SUV420H1 0.013 0 -10000 0 -10000 0 0
IRF1 0.14 0.18 0.54 14 -1.1 2 16
TP53 -0.014 0.18 -10000 0 -0.7 20 20
PPP5C 0.013 0 -10000 0 -10000 0 0
KRT17 -0.26 0.45 -10000 0 -1.3 39 39
KRT14 -0.37 0.61 -10000 0 -1.6 61 61
TBP 0.021 0.013 -10000 0 -10000 0 0
CREBBP 0.079 0.12 0.36 15 -10000 0 15
HDAC1 0.013 0 -10000 0 -10000 0 0
HDAC2 0.027 0.031 -10000 0 -10000 0 0
AP-1 -0.23 0.35 -10000 0 -0.84 48 48
MAPK14 0.014 0.007 -10000 0 -10000 0 0
MAPK10 -0.092 0.25 -10000 0 -0.67 47 47
MAPK11 0.014 0.007 -10000 0 -10000 0 0
KRT5 -0.21 0.35 -10000 0 -1 30 30
interleukin-1 receptor activity 0.015 0.031 -10000 0 -10000 0 0
NCOA1 0.016 0.001 -10000 0 -10000 0 0
STAT1 0.01 0.088 -10000 0 -0.64 5 5
CGA -0.086 0.18 -10000 0 -0.68 9 9
NF kappa B1 p50/RelA/Cbp/cortisol/GR alpha (monomer)/HDAC2 0.19 0.22 0.52 70 -10000 0 70
MAPK3 0.014 0.008 -10000 0 -10000 0 0
MAPK1 0.014 0.007 -10000 0 -10000 0 0
ICAM1 -0.17 0.33 -10000 0 -1 25 25
NFKB1 -0.028 0.094 -10000 0 -10000 0 0
MAPK8 -0.13 0.21 -10000 0 -0.61 30 30
MAPK9 0.014 0.007 -10000 0 -10000 0 0
cortisol/GR alpha (dimer) 0.031 0.18 0.51 8 -0.72 1 9
BAX -0.001 0.11 -10000 0 -10000 0 0
POMC -0.21 0.37 -10000 0 -1.1 27 27
EP300 0.081 0.12 0.35 20 -10000 0 20
cortisol/GR alpha (dimer)/p53 0.2 0.28 0.63 57 -0.5 4 61
proteasomal ubiquitin-dependent protein catabolic process 0.06 0.08 0.26 14 -10000 0 14
SGK1 0.13 0.17 -10000 0 -1.5 1 1
IL13 -0.18 0.28 -10000 0 -0.79 35 35
IL6 -0.25 0.46 -10000 0 -1.1 56 56
PRKACG 0 0 -10000 0 -10000 0 0
IL5 -0.16 0.22 -10000 0 -0.52 58 58
IL2 -0.19 0.28 -10000 0 -0.84 28 28
CDK5 0.014 0.004 -10000 0 -10000 0 0
PRKACB -0.004 0.11 -10000 0 -0.72 7 7
HSP90AA1 0.013 0 -10000 0 -10000 0 0
IL8 -0.26 0.45 -10000 0 -1.1 56 56
CDK5R1/CDK5 0.007 0.07 -10000 0 -0.52 5 5
NF kappa B1 p50/RelA/PKAc -0.028 0.14 -10000 0 -0.51 6 6
cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 0.22 0.24 0.59 63 -10000 0 63
SMARCA4 0.014 0.004 -10000 0 -10000 0 0
chromatin remodeling 0.16 0.16 0.46 35 -10000 0 35
NF kappa B1 p50/RelA/Cbp 0.035 0.18 0.49 6 -0.52 1 7
JUN (dimer) -0.14 0.22 -10000 0 -0.63 28 28
YWHAH 0.013 0 -10000 0 -10000 0 0
VIPR1 -0.12 0.29 -10000 0 -0.93 26 26
NR3C1 0.16 0.21 0.56 42 -10000 0 42
NR4A1 -0.059 0.18 -10000 0 -0.62 24 24
TIF2/SUV420H1 0.01 0.072 -10000 0 -0.54 5 5
MAPKKK cascade 0.036 0.17 0.51 8 -0.68 1 9
cortisol/GR alpha (dimer)/Src-1 0.23 0.26 0.62 69 -10000 0 69
PBX1 -0.076 0.24 -10000 0 -0.72 37 37
POU1F1 0.001 0.017 -10000 0 -10000 0 0
SELE -0.33 0.52 -10000 0 -1.1 78 78
cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A 0.16 0.16 0.46 34 -10000 0 34
cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 0.22 0.24 0.59 63 -10000 0 63
mol:cortisol 0.15 0.22 0.45 74 -0.22 5 79
MMP1 -0.31 0.53 -10000 0 -1.2 66 66
Endothelins

Figure S31.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S31.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 -0.027 0.28 -10000 0 -0.8 22 22
PTK2B 0.011 0.034 -10000 0 -0.58 1 1
mol:Ca2+ 0.031 0.18 -10000 0 -0.92 5 5
EDN1 -0.003 0.16 -10000 0 -0.51 12 12
EDN3 -0.043 0.17 -10000 0 -0.61 25 25
EDN2 -0.15 0.29 -10000 0 -0.66 73 73
HRAS/GDP -0.002 0.21 -10000 0 -0.74 13 13
ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.007 0.23 -10000 0 -0.66 19 19
ADCY4 -0.054 0.26 -10000 0 -0.81 20 20
ADCY5 -0.13 0.32 -10000 0 -0.76 41 41
ADCY6 -0.061 0.28 -10000 0 -0.84 23 23
ADCY7 -0.051 0.25 -10000 0 -0.8 20 20
ADCY1 -0.072 0.27 -10000 0 -0.82 23 23
ADCY2 -0.16 0.31 -10000 0 -0.75 46 46
ADCY3 -0.049 0.25 -10000 0 -0.78 20 20
ADCY8 -0.074 0.25 -10000 0 -0.75 23 23
ADCY9 -0.049 0.25 -10000 0 -0.78 20 20
arachidonic acid secretion -0.002 0.19 -10000 0 -0.62 14 14
ETB receptor/Endothelin-1/Gq/GTP 0.004 0.14 -10000 0 -0.53 11 11
GNAO1 0.001 0.091 -10000 0 -0.7 5 5
HRAS 0.01 0.034 -10000 0 -0.58 1 1
ETA receptor/Endothelin-1/G12/GTP -0.025 0.28 0.35 55 -0.74 22 77
ETA receptor/Endothelin-1/Gs/GTP -0.047 0.29 0.36 30 -0.84 20 50
mol:GTP 0.002 0.003 -10000 0 -10000 0 0
COL3A1 -0.079 0.38 -10000 0 -0.88 44 44
EDNRB -0.014 0.13 -10000 0 -0.71 10 10
response to oxidative stress 0 0 -10000 0 -10000 0 0
CYSLTR2 -0.058 0.34 -10000 0 -1.1 21 21
CYSLTR1 -0.06 0.34 -10000 0 -0.9 31 31
SLC9A1 -0.018 0.14 -10000 0 -0.39 13 13
mol:GDP -0.011 0.24 -10000 0 -0.83 14 14
SLC9A3 -0.079 0.26 -10000 0 -0.68 31 31
RAF1 -0.013 0.22 -10000 0 -0.73 15 15
JUN 0.032 0.18 -10000 0 -0.79 7 7
JAK2 -0.031 0.28 -10000 0 -0.81 22 22
mol:IP3 -0.012 0.24 -10000 0 -0.81 15 15
ETA receptor/Endothelin-1 -0.037 0.34 0.41 55 -0.85 25 80
PLCB1 -0.012 0.13 -10000 0 -0.72 10 10
PLCB2 -0.014 0.14 -10000 0 -0.73 11 11
ETA receptor/Endothelin-3 -0.059 0.19 -10000 0 -0.55 29 29
FOS -0.017 0.26 -10000 0 -0.86 21 21
Gai/GDP 0.002 0.12 -10000 0 -0.82 4 4
CRK 0.013 0 -10000 0 -10000 0 0
mol:Ca ++ -0.042 0.33 -10000 0 -0.94 24 24
BCAR1 0.013 0.001 -10000 0 -10000 0 0
PRKCB1 -0.01 0.22 -10000 0 -0.74 15 15
GNAQ 0.015 0.004 -10000 0 -10000 0 0
GNAZ -0.048 0.19 -10000 0 -0.62 29 29
GNAL -0.033 0.17 -10000 0 -0.68 20 20
Gs family/GDP -0.086 0.18 -10000 0 -0.68 17 17
ETA receptor/Endothelin-1/Gq/GTP 0.003 0.21 -10000 0 -0.74 13 13
MAPK14 0.002 0.18 -10000 0 -0.77 9 9
TRPC6 0.029 0.19 -10000 0 -1 5 5
GNAI2 0.013 0 -10000 0 -10000 0 0
GNAI3 0.013 0 -10000 0 -10000 0 0
GNAI1 0.008 0.06 -10000 0 -0.72 2 2
ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.006 0.19 -10000 0 -0.83 9 9
ETB receptor/Endothelin-2 -0.12 0.23 -10000 0 -0.5 82 82
ETB receptor/Endothelin-3 -0.042 0.16 -10000 0 -0.47 35 35
ETB receptor/Endothelin-1 -0.011 0.17 -10000 0 -0.57 16 16
MAPK3 -0.014 0.25 -10000 0 -0.8 20 20
MAPK1 -0.014 0.25 -10000 0 -0.8 20 20
Rac1/GDP -0.001 0.21 -10000 0 -0.74 13 13
cAMP biosynthetic process -0.11 0.28 -10000 0 -0.73 36 36
MAPK8 0.02 0.22 -10000 0 -0.95 9 9
SRC 0.013 0 -10000 0 -10000 0 0
ETB receptor/Endothelin-1/Gi/GTP -0.003 0.12 -10000 0 -0.43 11 11
p130Cas/CRK/Src/PYK2 0.008 0.22 -10000 0 -0.85 10 10
mol:K + 0 0 -10000 0 -10000 0 0
G12/GDP -0.001 0.21 -10000 0 -0.74 13 13
COL1A2 -0.082 0.42 -10000 0 -1 39 39
EntrezGene:2778 0 0 -10000 0 -10000 0 0
ETA receptor/Endothelin-2 -0.14 0.27 -10000 0 -0.53 78 78
mol:DAG -0.012 0.24 -10000 0 -0.81 15 15
MAP2K2 -0.009 0.22 -10000 0 -0.66 19 19
MAP2K1 -0.009 0.22 -10000 0 -0.74 14 14
EDNRA -0.016 0.22 -10000 0 -0.8 13 13
positive regulation of muscle contraction -0.016 0.25 -10000 0 -0.8 17 17
Gq family/GDP -0.067 0.18 -10000 0 -0.82 12 12
HRAS/GTP -0.018 0.24 -10000 0 -0.8 15 15
PRKCH -0.003 0.22 -10000 0 -0.79 13 13
RAC1 0.013 0 -10000 0 -10000 0 0
PRKCA -0.007 0.23 -10000 0 -0.81 13 13
PRKCB -0.034 0.27 -10000 0 -0.81 22 22
PRKCE -0.002 0.22 -10000 0 -0.86 11 11
PRKCD -0.003 0.22 -10000 0 -0.86 11 11
PRKCG -0.029 0.23 -10000 0 -0.76 15 15
regulation of vascular smooth muscle contraction -0.027 0.3 -10000 0 -1 20 20
PRKCQ -0.03 0.24 -10000 0 -0.71 20 20
PLA2G4A -0.007 0.21 -10000 0 -0.69 14 14
GNA14 -0.022 0.16 -10000 0 -0.68 16 16
GNA15 0.014 0.003 -10000 0 -10000 0 0
GNA12 0.013 0 -10000 0 -10000 0 0
GNA11 0.009 0.06 -10000 0 -0.72 2 2
Rac1/GTP -0.025 0.28 0.35 55 -0.75 22 77
MMP1 -0.2 0.44 -10000 0 -0.87 81 81
PDGFR-alpha signaling pathway

Figure S32.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S32.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA -0.039 0.18 -9999 0 -0.7 22 22
PDGF/PDGFRA/CRKL -0.021 0.14 -9999 0 -0.5 23 23
positive regulation of JUN kinase activity -0.027 0.098 -9999 0 -0.4 17 17
CRKL 0.011 0.034 -9999 0 -0.58 1 1
PDGF/PDGFRA/Caveolin-3 -0.18 0.26 -9999 0 -0.52 109 109
AP1 -0.084 0.25 -9999 0 -1 16 16
mol:IP3 -0.017 0.14 -9999 0 -0.52 22 22
PLCG1 -0.017 0.14 -9999 0 -0.52 22 22
PDGF/PDGFRA/alphaV Integrin -0.024 0.15 -9999 0 -0.53 24 24
RAPGEF1 0.013 0 -9999 0 -10000 0 0
CRK 0.013 0 -9999 0 -10000 0 0
mol:Ca2+ -0.017 0.14 -9999 0 -0.52 22 22
CAV3 -0.2 0.31 -9999 0 -0.67 90 90
CAV1 -0.049 0.2 -9999 0 -0.71 26 26
SHC/Grb2/SOS1 0.003 0.11 -9999 0 -0.4 17 17
PDGF/PDGFRA/Shf -0.038 0.18 -9999 0 -0.56 30 30
FOS -0.045 0.26 -9999 0 -1 16 16
JUN -0.008 0.029 -9999 0 -0.43 1 1
oligodendrocyte development -0.024 0.15 -9999 0 -0.53 24 24
GRB2 0.013 0 -9999 0 -10000 0 0
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
mol:DAG -0.017 0.14 -9999 0 -0.52 22 22
PDGF/PDGFRA -0.039 0.18 -9999 0 -0.7 22 22
actin cytoskeleton reorganization -0.023 0.14 -9999 0 -0.51 24 24
SRF 0.022 0.007 -9999 0 -10000 0 0
SHC1 0.013 0 -9999 0 -10000 0 0
PI3K -0.033 0.12 -9999 0 -0.44 20 20
PDGF/PDGFRA/Crk/C3G -0.03 0.11 -9999 0 -0.45 17 17
JAK1 -0.018 0.14 -9999 0 -0.51 23 23
ELK1/SRF 0.007 0.11 -9999 0 -0.45 1 1
SHB 0.008 0.06 -9999 0 -0.72 2 2
SHF -0.013 0.13 -9999 0 -0.7 11 11
CSNK2A1 0.006 0.016 -9999 0 -10000 0 0
GO:0007205 -0.017 0.14 -9999 0 -0.52 22 22
SOS1 0.013 0 -9999 0 -10000 0 0
Ras protein signal transduction -0.027 0.098 -9999 0 -0.4 17 17
PDGF/PDGFRA/SHB -0.023 0.14 -9999 0 -0.51 24 24
PDGF/PDGFRA/Caveolin-1 -0.066 0.2 -9999 0 -0.54 46 46
ITGAV 0.005 0.073 -9999 0 -0.72 3 3
ELK1 -0.009 0.13 -9999 0 -0.48 19 19
PIK3CA 0.013 0 -9999 0 -10000 0 0
PDGF/PDGFRA/Crk -0.019 0.14 -9999 0 -0.5 22 22
JAK-STAT cascade -0.018 0.14 -9999 0 -0.5 23 23
cell proliferation -0.038 0.18 -9999 0 -0.55 30 30
Coregulation of Androgen receptor activity

Figure S33.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S33.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NRIP1 0.006 0.044 -9999 0 -0.72 1 1
SVIL 0.006 0.044 -9999 0 -0.72 1 1
ZNF318 0.025 0.036 -9999 0 -10000 0 0
JMJD2C -0.002 0.029 -9999 0 -0.095 24 24
T-DHT/AR/Ubc9 -0.1 0.19 -9999 0 -0.48 56 56
CARM1 0.012 0.002 -9999 0 -10000 0 0
PRDX1 0.013 0.002 -9999 0 -10000 0 0
PELP1 0.015 0.006 -9999 0 -10000 0 0
CTNNB1 0.005 0.061 -9999 0 -0.74 2 2
AKT1 0.016 0.01 -9999 0 -10000 0 0
PTK2B 0.008 0.035 -9999 0 -0.58 1 1
MED1 0.012 0.05 -9999 0 -0.59 2 2
MAK -0.011 0.15 -9999 0 -0.62 17 17
response to oxidative stress 0.001 0.002 -9999 0 -10000 0 0
HIP1 -0.001 0.085 -9999 0 -0.72 4 4
GSN 0.008 0.015 -9999 0 -10000 0 0
NCOA2 0 0.094 -9999 0 -0.72 5 5
NCOA6 0.01 0.011 -9999 0 -10000 0 0
DNA-PK 0.016 0.042 -9999 0 -10000 0 0
NCOA4 0.012 0.002 -9999 0 -10000 0 0
PIAS3 0.01 0.01 -9999 0 -10000 0 0
cell proliferation -0.041 0.13 -9999 0 -0.5 16 16
XRCC5 0.015 0.008 -9999 0 -10000 0 0
UBE3A 0.006 0.021 -9999 0 -10000 0 0
T-DHT/AR/SNURF -0.14 0.22 -9999 0 -0.5 73 73
FHL2 -0.049 0.2 -9999 0 -1.2 7 7
RANBP9 0.01 0.011 -9999 0 -10000 0 0
JMJD1A -0.051 0.073 -9999 0 -0.13 127 127
CDK6 -0.001 0.097 -9999 0 -0.68 6 6
TGFB1I1 0.004 0.057 -9999 0 -0.67 2 2
T-DHT/AR/CyclinD1 -0.13 0.21 -9999 0 -0.49 71 71
XRCC6 0.015 0.008 -9999 0 -10000 0 0
T-DHT/AR -0.13 0.22 -9999 0 -0.56 46 46
CTDSP1 0.011 0.005 -9999 0 -10000 0 0
CTDSP2 0.021 0.024 -9999 0 -10000 0 0
BRCA1 0.009 0.013 -9999 0 -10000 0 0
TCF4 0.016 0.046 -9999 0 -0.72 1 1
CDKN2A -0.3 0.35 -9999 0 -0.68 137 137
SRF 0.021 0.022 -9999 0 -10000 0 0
NKX3-1 -0.13 0.2 -9999 0 -0.94 9 9
KLK3 -0.062 0.28 -9999 0 -1.6 7 7
TMF1 0.011 0.004 -9999 0 -10000 0 0
HNRNPA1 0.017 0.014 -9999 0 -10000 0 0
AOF2 -0.005 0.015 -9999 0 -0.073 7 7
APPL1 0.029 0.021 -9999 0 -10000 0 0
T-DHT/AR/Caspase 8 -0.098 0.19 -9999 0 -0.47 56 56
AR -0.14 0.27 -9999 0 -0.7 56 56
UBA3 0.011 0.005 -9999 0 -10000 0 0
PATZ1 0.013 0.062 -9999 0 -0.72 2 2
PAWR 0.011 0.004 -9999 0 -10000 0 0
PRKDC 0.015 0.008 -9999 0 -10000 0 0
PA2G4 0.018 0.015 -9999 0 -10000 0 0
UBE2I 0.013 0 -9999 0 -10000 0 0
T-DHT/AR/Cyclin D3/CDK11 p58 -0.089 0.17 -9999 0 -0.44 56 56
RPS6KA3 0.008 0.015 -9999 0 -10000 0 0
T-DHT/AR/ARA70 -0.1 0.19 -9999 0 -0.48 56 56
LATS2 0.015 0.044 -9999 0 -0.72 1 1
T-DHT/AR/PRX1 -0.087 0.17 -9999 0 -0.43 56 56
Cyclin D3/CDK11 p58 0.01 0.003 -9999 0 -10000 0 0
VAV3 -0.039 0.18 -9999 0 -0.73 20 20
KLK2 -0.094 0.17 -9999 0 -0.6 24 24
CASP8 0.014 0.004 -9999 0 -10000 0 0
T-DHT/AR/TIF2/CARM1 -0.094 0.18 -9999 0 -0.48 49 49
TMPRSS2 -0.42 0.49 -9999 0 -1 102 102
CCND1 -0.029 0.16 -9999 0 -0.63 19 19
PIAS1 0.006 0.021 -9999 0 -10000 0 0
mol:T-DHT -0.027 0.036 -9999 0 -0.076 77 77
CDC2L1 0 0.001 -9999 0 -10000 0 0
PIAS4 0.002 0.033 -9999 0 -10000 0 0
T-DHT/AR/CDK6 -0.11 0.2 -9999 0 -0.5 58 58
CMTM2 -0.024 0.15 -9999 0 -0.61 18 18
SNURF -0.039 0.18 -9999 0 -0.72 21 21
ZMIZ1 -0.013 0.052 -9999 0 -0.72 1 1
CCND3 0.013 0.001 -9999 0 -10000 0 0
TGIF1 0.017 0.014 -9999 0 -10000 0 0
FKBP4 0.01 0.011 -9999 0 -10000 0 0
Ephrin A reverse signaling

Figure S34.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S34.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAPKKK cascade -0.032 0.11 -9999 0 -0.42 23 23
EFNA5 -0.019 0.15 -9999 0 -0.72 13 13
FYN -0.013 0.12 -9999 0 -0.4 25 25
neuron projection morphogenesis -0.032 0.11 -9999 0 -0.42 23 23
cell-cell signaling 0 0 -9999 0 -10000 0 0
Ephrin A5/EPHA5 -0.032 0.11 -9999 0 -0.43 23 23
EPHA5 -0.012 0.11 -9999 0 -0.58 10 10
Thromboxane A2 receptor signaling

Figure S35.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S35.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGM2 -0.027 0.16 -10000 0 -0.64 18 18
GNB1/GNG2 -0.059 0.081 -10000 0 -0.22 25 25
AKT1 -0.02 0.12 -10000 0 -0.27 1 1
EGF -0.14 0.29 -10000 0 -0.66 70 70
mol:TXA2 0 0.001 -10000 0 -10000 0 0
FGR 0.008 0.11 -10000 0 -0.51 6 6
mol:Ca2+ -0.053 0.17 -10000 0 -0.36 35 35
LYN 0.019 0.091 -10000 0 -0.49 5 5
RhoA/GTP -0.038 0.053 -10000 0 -10000 0 0
mol:PGI2 0 0 -10000 0 -10000 0 0
SYK -0.058 0.18 -10000 0 -0.38 34 34
GNG2 0.001 0.091 -10000 0 -0.7 5 5
ARRB2 0.013 0 -10000 0 -10000 0 0
TP alpha/Gq family/GDP/G beta5/gamma2 0.018 0.082 -10000 0 -0.54 5 5
G beta5/gamma2 -0.077 0.11 -10000 0 -0.31 27 27
PRKCH -0.063 0.19 -10000 0 -0.42 31 31
DNM1 -0.023 0.16 -10000 0 -0.71 15 15
TXA2/TP beta/beta Arrestin3 -0.017 0.06 -10000 0 -0.27 15 15
mol:GTP 0 0.001 -10000 0 -10000 0 0
PTGDR -0.017 0.14 -10000 0 -0.72 12 12
G12 family/GTP -0.093 0.13 -10000 0 -0.34 34 34
ADRBK1 0.013 0 -10000 0 -10000 0 0
ADRBK2 0.003 0.084 -10000 0 -0.72 4 4
RhoA/GTP/ROCK1 0.009 0.009 -10000 0 -10000 0 0
mol:GDP 0.029 0.13 0.42 14 -10000 0 14
mol:NADP -0.001 0.093 -10000 0 -0.66 6 6
RAB11A 0.013 0 -10000 0 -10000 0 0
PRKG1 -0.032 0.17 -10000 0 -0.7 19 19
mol:IP3 -0.073 0.21 -10000 0 -0.46 35 35
cell morphogenesis 0.009 0.009 -10000 0 -10000 0 0
PLCB2 -0.11 0.28 -10000 0 -0.59 54 54
mol:cGMP 0 0.001 -10000 0 -10000 0 0
BLK -0.067 0.17 -10000 0 -0.54 11 11
mol:PDG2 0 0 -10000 0 -10000 0 0
HCK 0.012 0.11 -10000 0 -0.51 8 8
RHOA 0.013 0 -10000 0 -10000 0 0
PTGIR -0.001 0.097 -10000 0 -0.68 6 6
PRKCB1 -0.072 0.2 -10000 0 -0.41 55 55
GNAQ 0.013 0 -10000 0 -10000 0 0
mol:L-citrulline -0.001 0.093 -10000 0 -0.66 6 6
TXA2/TXA2-R family -0.11 0.27 -10000 0 -0.56 61 61
LCK 0 0.12 -10000 0 -0.5 8 8
TXA2/TP beta/beta Arrestin3/RAB11/GDP -0.02 0.088 -10000 0 -0.66 3 3
TXA2-R family/G12 family/GDP/G beta/gamma 0.022 0.042 -10000 0 -0.34 2 2
TXA2/TP beta/beta Arrestin2/RAB11/GDP -0.02 0.087 -10000 0 -0.66 3 3
MAPK14 -0.028 0.13 -10000 0 -0.26 17 17
TGM2/GTP -0.086 0.23 -10000 0 -0.52 37 37
MAPK11 -0.028 0.13 -10000 0 -0.26 9 9
ARHGEF1 -0.022 0.1 -10000 0 -10000 0 0
GNAI2 0.013 0 -10000 0 -10000 0 0
JNK cascade -0.072 0.2 -10000 0 -0.41 60 60
RAB11/GDP 0.013 0.002 -10000 0 -10000 0 0
ICAM1 -0.047 0.16 -10000 0 -0.34 23 23
cAMP biosynthetic process -0.068 0.19 -10000 0 -0.42 35 35
Gq family/GTP/EBP50 0.013 0.063 -10000 0 -0.34 4 4
actin cytoskeleton reorganization 0.009 0.009 -10000 0 -10000 0 0
SRC 0.021 0.089 -10000 0 -0.49 5 5
GNB5 0.013 0 -10000 0 -10000 0 0
GNB1 0.013 0 -10000 0 -10000 0 0
EGF/EGFR -0.033 0.12 -10000 0 -0.39 13 13
VCAM1 -0.068 0.19 -10000 0 -0.38 56 56
TP beta/Gq family/GDP/G beta5/gamma2 0.018 0.082 -10000 0 -0.54 5 5
platelet activation -0.039 0.17 -10000 0 -0.34 26 26
PGI2/IP -0.004 0.073 -10000 0 -0.51 6 6
PRKACA -0.001 0.094 -10000 0 -0.38 15 15
Gq family/GDP/G beta5/gamma2 0.017 0.083 -10000 0 -0.54 5 5
TXA2/TP beta/beta Arrestin2 -0.03 0.13 -10000 0 -0.62 13 13
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TBXA2R 0.001 0.11 -10000 0 -0.65 4 4
mol:DAG -0.084 0.23 -10000 0 -0.48 55 55
EGFR -0.019 0.14 -10000 0 -0.63 15 15
TXA2/TP alpha -0.099 0.26 -10000 0 -0.59 37 37
Gq family/GTP -0.012 0.058 -10000 0 -0.26 13 13
YES1 0.021 0.089 -10000 0 -0.49 5 5
GNAI2/GTP -0.023 0.092 -10000 0 -0.58 5 5
PGD2/DP -0.016 0.11 -10000 0 -0.55 12 12
SLC9A3R1 0.008 0.06 -10000 0 -0.72 2 2
FYN 0.018 0.1 -10000 0 -0.52 6 6
mol:NO -0.001 0.093 -10000 0 -0.66 6 6
GNA15 0.013 0 -10000 0 -10000 0 0
PGK/cGMP -0.032 0.13 -10000 0 -0.48 23 23
RhoA/GDP 0.013 0.002 -10000 0 -10000 0 0
TP alpha/TGM2/GDP/G beta/gamma -0.02 0.14 -10000 0 -0.92 4 4
NOS3 -0.001 0.094 -10000 0 -0.66 6 6
RAC1 0.013 0 -10000 0 -10000 0 0
PRKCA -0.065 0.19 -10000 0 -0.43 29 29
PRKCB -0.08 0.22 -10000 0 -0.48 41 41
PRKCE -0.06 0.19 -10000 0 -0.42 30 30
PRKCD -0.07 0.2 -10000 0 -0.41 56 56
PRKCG -0.084 0.22 -10000 0 -0.43 63 63
muscle contraction -0.098 0.25 -10000 0 -0.52 61 61
PRKCZ -0.057 0.18 -10000 0 -0.38 34 34
ARR3 0 0 -10000 0 -10000 0 0
TXA2/TP beta -0.005 0.11 -10000 0 -0.66 5 5
PRKCQ -0.079 0.2 -10000 0 -0.41 53 53
MAPKKK cascade -0.094 0.24 -10000 0 -0.5 60 60
SELE -0.077 0.2 -10000 0 -0.42 61 61
TP beta/GNAI2/GDP/G beta/gamma -0.004 0.11 -10000 0 -0.86 3 3
ROCK1 0.013 0 -10000 0 -10000 0 0
GNA14 -0.024 0.16 -10000 0 -0.68 16 16
chemotaxis -0.13 0.3 -10000 0 -0.64 61 61
GNA12 0.013 0 -10000 0 -10000 0 0
GNA13 0.013 0 -10000 0 -10000 0 0
GNA11 0.008 0.06 -10000 0 -0.72 2 2
Rac1/GTP 0.006 0.005 -10000 0 -10000 0 0
EGFR-dependent Endothelin signaling events

Figure S36.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S36.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HRAS 0.011 0.034 -9999 0 -0.58 1 1
EGFR -0.019 0.14 -9999 0 -0.63 15 15
EGF/EGFR -0.12 0.19 -9999 0 -0.43 57 57
EGF/EGFR dimer/SHC/GRB2/SOS1 -0.096 0.16 -9999 0 -0.66 3 3
mol:GTP 0 0 -9999 0 -10000 0 0
EDNRA -0.012 0.13 -9999 0 -0.72 10 10
response to oxidative stress 0 0 -9999 0 -10000 0 0
EGF -0.14 0.29 -9999 0 -0.66 70 70
EGF/EGFR dimer/SHC -0.12 0.2 -9999 0 -0.43 82 82
mol:GDP -0.095 0.16 -9999 0 -0.65 3 3
mol:Ca2+ 0 0 -9999 0 -10000 0 0
EDN1 -0.002 0.1 -9999 0 -0.72 6 6
GRB2/SOS1 0.019 0 -9999 0 -10000 0 0
HRAS/GTP -0.088 0.15 -9999 0 -0.61 4 4
SHC1 0.013 0 -9999 0 -10000 0 0
HRAS/GDP -0.09 0.15 -9999 0 -0.62 4 4
FRAP1 -0.066 0.17 -9999 0 -0.63 3 3
EGF/EGFR dimer -0.12 0.24 -9999 0 -0.5 82 82
SOS1 0.013 0 -9999 0 -10000 0 0
GRB2 0.013 0 -9999 0 -10000 0 0
ETA receptor/Endothelin-1 -0.01 0.13 -9999 0 -0.57 15 15
Signaling events mediated by Stem cell factor receptor (c-Kit)

Figure S37.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S37.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K1 -0.034 0.17 -10000 0 -0.44 32 32
CRKL -0.012 0.13 -10000 0 -0.43 21 21
HRAS -0.022 0.17 -10000 0 -0.6 12 12
mol:PIP3 -0.026 0.13 -10000 0 -0.43 20 20
SPRED1 0.01 0.042 -10000 0 -0.72 1 1
SPRED2 0.013 0 -10000 0 -10000 0 0
GAB1 -0.019 0.14 -10000 0 -0.44 23 23
FOXO3 -0.01 0.13 -10000 0 -0.41 20 20
AKT1 -0.018 0.14 -10000 0 -0.45 20 20
BAD -0.009 0.13 -10000 0 -0.41 19 19
megakaryocyte differentiation -0.044 0.18 -10000 0 -0.47 34 34
GSK3B -0.009 0.13 -10000 0 -0.41 20 20
RAF1 -0.007 0.14 -10000 0 -0.49 9 9
SHC1 0.013 0 -10000 0 -10000 0 0
STAT3 -0.019 0.14 -10000 0 -0.44 23 23
STAT1 -0.069 0.31 -10000 0 -1 24 24
HRAS/SPRED1 -0.01 0.14 -10000 0 -0.52 9 9
cell proliferation -0.021 0.14 -10000 0 -0.44 22 22
PIK3CA 0.013 0 -10000 0 -10000 0 0
TEC 0.001 0.091 -10000 0 -0.7 5 5
RPS6KB1 -0.02 0.14 -10000 0 -0.44 24 24
HRAS/SPRED2 -0.009 0.14 -10000 0 -0.49 9 9
LYN/TEC/p62DOK -0.052 0.14 -10000 0 -0.47 19 19
MAPK3 0.01 0.1 -10000 0 -0.34 6 6
STAP1 -0.065 0.18 -10000 0 -0.45 43 43
GRAP2 -0.05 0.2 -10000 0 -0.67 28 28
JAK2 -0.099 0.24 -10000 0 -0.85 23 23
STAT1 (dimer) -0.066 0.3 -10000 0 -1 24 24
mol:Gleevec 0 0.006 -10000 0 -10000 0 0
GRB2/SOCS1/VAV1 -0.065 0.16 -10000 0 -0.47 27 27
actin filament polymerization -0.026 0.15 -10000 0 -0.44 28 28
LYN 0.01 0.042 -10000 0 -0.72 1 1
STAP1/STAT5A (dimer) -0.068 0.22 -10000 0 -0.61 30 30
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
CBL/CRKL/GRB2 0.003 0.12 -10000 0 -0.5 3 3
PI3K -0.009 0.14 -10000 0 -0.45 20 20
PTEN 0.01 0.042 -10000 0 -0.72 1 1
SCF/KIT/EPO/EPOR -0.098 0.38 -10000 0 -1.4 20 20
MAPK8 -0.022 0.14 -10000 0 -0.45 22 22
STAT3 (dimer) -0.018 0.14 -10000 0 -0.43 23 23
positive regulation of transcription 0.013 0.088 -10000 0 -0.3 1 1
mol:GDP -0.076 0.16 -10000 0 -0.62 14 14
PIK3C2B -0.022 0.14 -10000 0 -0.45 24 24
CBL/CRKL -0.004 0.13 -10000 0 -0.4 20 20
FER -0.019 0.14 -10000 0 -0.44 23 23
SH2B3 -0.02 0.14 -10000 0 -0.47 20 20
PDPK1 -0.017 0.12 -10000 0 -0.39 20 20
SNAI2 -0.019 0.14 -10000 0 -0.44 23 23
positive regulation of cell proliferation -0.041 0.23 -10000 0 -0.74 23 23
KITLG 0.009 0.062 -10000 0 -0.74 2 2
cell motility -0.041 0.23 -10000 0 -0.74 23 23
PTPN6 0.011 0.043 -10000 0 -0.72 1 1
EPOR 0.004 0.11 -10000 0 -10000 0 0
STAT5A (dimer) -0.029 0.19 -10000 0 -0.61 23 23
SOCS1 -0.002 0.099 -10000 0 -0.64 7 7
cell migration 0.047 0.17 0.45 33 -10000 0 33
SOS1 0.013 0 -10000 0 -10000 0 0
EPO -0.067 0.2 -10000 0 -0.6 39 39
VAV1 -0.021 0.16 -10000 0 -0.72 14 14
GRB10 -0.027 0.15 -10000 0 -0.46 26 26
PTPN11 0.013 0.006 -10000 0 -10000 0 0
SCF/KIT -0.028 0.14 -10000 0 -0.46 24 24
GO:0007205 0.001 0.008 -10000 0 -10000 0 0
MAP2K1 0.005 0.11 -10000 0 -0.38 7 7
CBL 0.013 0 -10000 0 -10000 0 0
KIT -0.078 0.38 -10000 0 -1.3 23 23
MAP2K2 0.005 0.11 -10000 0 -0.37 8 8
SHC/Grb2/SOS1 -0.042 0.12 -10000 0 -0.42 20 20
STAT5A -0.031 0.2 -10000 0 -0.63 23 23
GRB2 0.013 0 -10000 0 -10000 0 0
response to radiation -0.018 0.14 -10000 0 -0.43 23 23
SHC/GRAP2 -0.029 0.15 -10000 0 -0.5 28 28
PTPRO -0.045 0.18 -10000 0 -0.48 34 34
SH2B2 -0.027 0.15 -10000 0 -0.45 28 28
DOK1 0.005 0.073 -10000 0 -0.72 3 3
MATK -0.048 0.17 -10000 0 -0.46 32 32
CREBBP 0.031 0.014 -10000 0 -10000 0 0
BCL2 -0.035 0.25 -10000 0 -1.2 9 9
Caspase cascade in apoptosis

Figure S38.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S38.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TOP1 -0.032 0.18 -10000 0 -0.48 33 33
ACTA1 -0.13 0.23 -10000 0 -0.62 44 44
NUMA1 -0.033 0.18 -10000 0 -0.48 33 33
SPTAN1 -0.052 0.23 -10000 0 -0.64 33 33
LIMK1 -0.052 0.23 -10000 0 -0.64 33 33
BIRC3 -0.038 0.17 -10000 0 -0.61 25 25
BIRC2 -0.001 0.09 -10000 0 -0.58 7 7
BAX 0.013 0 -10000 0 -10000 0 0
CASP10 -0.07 0.24 -10000 0 -0.64 39 39
CRMA 0 0 -10000 0 -10000 0 0
XIAP 0.013 0 -10000 0 -10000 0 0
PTK2 -0.032 0.18 -10000 0 -0.48 33 33
DIABLO 0.013 0 -10000 0 -10000 0 0
apoptotic nuclear changes -0.05 0.22 -10000 0 -0.62 33 33
response to UV 0 0 -10000 0 -10000 0 0
CRADD 0.013 0 -10000 0 -10000 0 0
GSN -0.052 0.23 -10000 0 -0.64 33 33
MADD 0.013 0 -10000 0 -10000 0 0
TFAP2A -0.038 0.19 -10000 0 -0.73 19 19
BID -0.021 0.11 -10000 0 -0.3 36 36
MAP3K1 -0.007 0.072 -10000 0 -0.23 11 11
TRADD 0.013 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.019 0.002 -10000 0 -10000 0 0
mol:Activated DNA 0 0 -10000 0 -10000 0 0
ARHGDIB -0.052 0.23 -10000 0 -0.64 33 33
CASP9 0.013 0 -10000 0 -10000 0 0
DNA repair -0.001 0.062 -10000 0 -0.22 2 2
neuron apoptosis 0.016 0.024 -10000 0 -10000 0 0
mol:NAD 0 0 -10000 0 -10000 0 0
DNA fragmentation during apoptosis -0.044 0.22 -10000 0 -0.61 33 33
APAF1 0.013 0 -10000 0 -10000 0 0
CASP6 -0.007 0.11 -10000 0 -0.5 4 4
TRAF2 0.009 0.048 -10000 0 -0.58 2 2
ICAD/CAD -0.043 0.22 -10000 0 -0.62 32 32
CASP7 0.016 0.074 0.32 8 -10000 0 8
KRT18 -0.008 0.11 -10000 0 -0.66 7 7
apoptosis -0.033 0.2 -10000 0 -0.67 18 18
DFFA -0.052 0.23 -10000 0 -0.64 33 33
DFFB -0.052 0.23 -10000 0 -0.64 33 33
PARP1 0.001 0.063 0.22 2 -10000 0 2
actin filament polymerization 0.045 0.22 0.59 33 -10000 0 33
TNF -0.061 0.21 -10000 0 -0.66 33 33
CYCS -0.014 0.082 -10000 0 -0.25 19 19
SATB1 -0.01 0.13 -10000 0 -0.55 8 8
SLK -0.052 0.23 -10000 0 -0.64 33 33
p15 BID/BAX -0.013 0.099 -10000 0 -0.34 12 12
CASP2 0.01 0.095 -10000 0 -0.44 4 4
JNK cascade 0.007 0.071 0.23 11 -10000 0 11
CASP3 -0.062 0.24 -10000 0 -0.68 33 33
LMNB2 0.012 0.076 -10000 0 -0.45 2 2
RIPK1 0.013 0 -10000 0 -10000 0 0
CASP4 0.008 0.06 -10000 0 -0.72 2 2
Mammalian IAPs/DIABLO -0.009 0.12 -10000 0 -0.54 9 9
negative regulation of DNA binding -0.037 0.19 -10000 0 -0.72 19 19
stress fiber formation -0.05 0.22 -10000 0 -0.62 33 33
GZMB -0.08 0.26 -10000 0 -0.67 45 45
CASP1 0.012 0.042 -10000 0 -0.41 3 3
LMNB1 0.012 0.076 -10000 0 -0.45 2 2
APP 0.016 0.024 -10000 0 -10000 0 0
TNFRSF1A 0.013 0 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
CASP8 0.011 0 -10000 0 -10000 0 0
VIM -0.036 0.19 -10000 0 -0.53 32 32
LMNA 0.012 0.076 -10000 0 -0.45 2 2
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD 0.004 0.096 -10000 0 -0.42 5 5
LRDD 0.009 0.048 -10000 0 -0.58 2 2
SREBF1 -0.053 0.23 -10000 0 -0.64 33 33
APAF-1/Caspase 9 0.005 0.066 0.39 5 -10000 0 5
nuclear fragmentation during apoptosis -0.032 0.17 -10000 0 -0.47 33 33
CFL2 -0.047 0.22 -10000 0 -0.61 33 33
GAS2 -0.061 0.23 -10000 0 -0.62 35 35
positive regulation of apoptosis 0.015 0.077 -10000 0 -0.45 2 2
PRF1 -0.049 0.2 -10000 0 -0.68 27 27
Visual signal transduction: Cones

Figure S39.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S39.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Cone Metarhodopsin II/Cone Transducin -0.034 0.11 -9999 0 -0.39 26 26
RGS9BP -0.023 0.15 -9999 0 -0.66 16 16
mol:GTP 0 0 -9999 0 -10000 0 0
GRK1 0 0 -9999 0 -10000 0 0
mol:Na + -0.041 0.13 -9999 0 -0.43 29 29
mol:ADP -0.052 0.17 -9999 0 -0.5 37 37
GNAT2 0.009 0.034 -9999 0 -0.58 1 1
RGS9-1/Gbeta5/R9AP -0.037 0.12 -9999 0 -0.42 27 27
mol:GDP 0 0 -9999 0 -10000 0 0
PDE6H/GNAT2/GTP -0.001 0.021 -9999 0 -0.37 1 1
GRK7 -0.07 0.22 -9999 0 -0.66 37 37
CNGB3 -0.044 0.19 -9999 0 -0.69 24 24
Cone Metarhodopsin II/X-Arrestin 0 0 -9999 0 -10000 0 0
mol:Ca2+ -0.068 0.18 -9999 0 -0.46 42 42
Cone PDE6 -0.032 0.1 -9999 0 -0.4 15 15
Cone Metarhodopsin II -0.041 0.13 -9999 0 -0.4 37 37
Na + (4 Units) -0.084 0.17 -9999 0 -0.46 42 42
GNAT2/GDP -0.032 0.1 -9999 0 -0.4 15 15
GNB5 0.013 0 -9999 0 -10000 0 0
mol:GMP (4 units) 0.006 0.02 -9999 0 -0.34 1 1
Cone Transducin -0.014 0.13 -9999 0 -0.42 26 26
SLC24A2 -0.071 0.22 -9999 0 -0.68 36 36
GNB3/GNGT2 -0.027 0.16 -9999 0 -0.53 25 25
GNB3 -0.031 0.17 -9999 0 -0.69 19 19
GNAT2/GTP 0.007 0.025 -9999 0 -0.43 1 1
CNGA3 -0.001 0.076 -9999 0 -0.58 5 5
ARR3 0 0 -9999 0 -10000 0 0
absorption of light 0 0 -9999 0 -10000 0 0
cGMP/Cone CNG Channel -0.041 0.13 -9999 0 -0.43 29 29
mol:Pi -0.037 0.12 -9999 0 -0.41 27 27
Cone CNG Channel -0.035 0.11 -9999 0 -0.38 21 21
mol:all-trans-retinal 0 0 -9999 0 -10000 0 0
mol:K + -0.071 0.22 -9999 0 -0.68 36 36
RGS9 -0.012 0.13 -9999 0 -0.66 11 11
PDE6C 0 0 -9999 0 -10000 0 0
GNGT2 -0.004 0.11 -9999 0 -0.7 7 7
mol:cGMP (4 units) 0 0 -9999 0 -10000 0 0
PDE6H 0 0 -9999 0 -10000 0 0
JNK signaling in the CD4+ TCR pathway

Figure S40.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S40.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
LAT/GRAP2/SLP76/HPK1 -0.064 0.27 -9999 0 -0.68 39 39
MAP4K1 -0.046 0.19 -9999 0 -0.68 26 26
MAP3K8 0.008 0.054 -9999 0 -0.66 2 2
PRKCB -0.049 0.2 -9999 0 -0.68 27 27
DBNL 0.013 0 -9999 0 -10000 0 0
CRKL 0.011 0.034 -9999 0 -0.58 1 1
MAP3K1 -0.021 0.2 -9999 0 -0.73 15 15
JUN -0.031 0.22 -9999 0 -0.82 19 19
MAP3K7 -0.021 0.2 -9999 0 -0.73 15 15
GRAP2 -0.05 0.2 -9999 0 -0.67 28 28
CRK 0.013 0 -9999 0 -10000 0 0
MAP2K4 -0.013 0.19 -9999 0 -0.71 15 15
LAT -0.013 0.13 -9999 0 -0.64 12 12
LCP2 -0.008 0.12 -9999 0 -0.69 9 9
MAPK8 -0.04 0.23 -9999 0 -0.88 19 19
LAT/GRAP2/SLP76/HPK1/HIP-55/CRK family -0.031 0.21 -9999 0 -0.78 15 15
LAT/GRAP2/SLP76/HPK1/HIP-55 -0.087 0.24 -9999 0 -0.9 19 19
a4b1 and a4b7 Integrin signaling

Figure S41.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S41.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ITGB1 0.011 0.034 -9999 0 -0.58 1 1
ITGB7 -0.004 0.11 -9999 0 -0.72 7 7
ITGA4 -0.034 0.18 -9999 0 -0.69 20 20
alpha4/beta7 Integrin -0.029 0.16 -9999 0 -0.54 26 26
alpha4/beta1 Integrin -0.018 0.14 -9999 0 -0.51 21 21
Signaling events mediated by PTP1B

Figure S42.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S42.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB -0.011 0.13 -10000 0 -0.71 10 10
Jak2/Leptin Receptor -0.066 0.11 -10000 0 -0.43 9 9
PTP1B/AKT1 -0.003 0.075 -10000 0 -0.39 3 3
FYN 0.006 0.069 -10000 0 -0.68 3 3
p210 bcr-abl/PTP1B -0.01 0.083 -10000 0 -0.37 7 7
EGFR -0.022 0.14 -10000 0 -0.64 15 15
EGF/EGFR -0.11 0.18 -10000 0 -0.45 47 47
CSF1 -0.007 0.12 -10000 0 -0.72 8 8
AKT1 0.013 0.001 -10000 0 -10000 0 0
INSR 0.01 0.042 -10000 0 -0.73 1 1
PTP1B/N-cadherin -0.09 0.19 -10000 0 -0.45 53 53
Insulin Receptor/Insulin -0.02 0.052 -10000 0 -0.35 3 3
HCK -0.006 0.12 -10000 0 -0.71 8 8
CRK 0.013 0 -10000 0 -10000 0 0
TYK2 -0.003 0.079 -10000 0 -0.42 3 3
EGF -0.14 0.29 -10000 0 -0.67 70 70
YES1 0.013 0 -10000 0 -10000 0 0
CAV1 -0.038 0.13 -10000 0 -0.42 16 16
TXN 0.008 0.035 -10000 0 -0.59 1 1
PTP1B/IRS1/GRB2 -0.006 0.1 -10000 0 -0.45 10 10
cell migration 0.01 0.083 0.37 7 -10000 0 7
STAT3 0.012 0.001 -10000 0 -10000 0 0
PRLR -0.18 0.3 -10000 0 -0.66 85 85
ITGA2B -0.022 0.14 -10000 0 -0.63 16 16
CSF1R -0.03 0.17 -10000 0 -0.7 18 18
Prolactin Receptor/Prolactin -0.14 0.23 -10000 0 -0.5 88 88
FGR -0.014 0.13 -10000 0 -0.66 12 12
PTP1B/p130 Cas -0.003 0.078 -10000 0 -0.37 5 5
Crk/p130 Cas 0.004 0.076 -10000 0 -0.45 2 2
DOK1 -0.006 0.11 -10000 0 -0.48 10 10
JAK2 -0.057 0.12 -10000 0 -0.37 20 20
Jak2/Leptin Receptor/Leptin -0.064 0.11 -10000 0 -0.51 4 4
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
PTPN1 -0.011 0.083 -10000 0 -0.38 7 7
LYN 0.01 0.042 -10000 0 -0.72 1 1
CDH2 -0.15 0.29 -10000 0 -0.67 71 71
SRC 0.012 0.032 -10000 0 -10000 0 0
ITGB3 -0.035 0.18 -10000 0 -0.7 20 20
CAT1/PTP1B -0.099 0.19 -10000 0 -0.56 25 25
CAPN1 0.01 0.043 -10000 0 -0.73 1 1
CSK 0.013 0 -10000 0 -10000 0 0
PI3K -0.016 0.052 -10000 0 -10000 0 0
mol:H2O2 -0.002 0.004 -10000 0 -10000 0 0
STAT3 (dimer) -0.057 0.1 -10000 0 -0.55 2 2
negative regulation of transcription -0.056 0.12 -10000 0 -0.37 20 20
FCGR2A -0.008 0.12 -10000 0 -0.69 9 9
FER 0.009 0.006 -10000 0 -10000 0 0
alphaIIb/beta3 Integrin -0.051 0.17 -10000 0 -0.53 33 33
BLK -0.18 0.3 -10000 0 -0.64 87 87
Insulin Receptor/Insulin/Shc 0.006 0.029 -10000 0 -0.47 1 1
RHOA 0.012 0.002 -10000 0 -10000 0 0
LEPR 0.008 0.054 -10000 0 -0.65 2 2
BCAR1 0.013 0 -10000 0 -10000 0 0
p210 bcr-abl/Grb2 0.013 0 -10000 0 -10000 0 0
mol:NADPH -0.001 0.003 -10000 0 -10000 0 0
TRPV6 -0.12 0.21 -10000 0 -0.6 32 32
PRL -0.006 0.075 -10000 0 -0.59 5 5
SOCS3 0.013 0.087 -10000 0 -1.5 1 1
SPRY2 -0.006 0.1 -10000 0 -0.64 8 8
Insulin Receptor/Insulin/IRS1 -0.006 0.083 -10000 0 -0.48 9 9
CSF1/CSF1R -0.028 0.17 -10000 0 -0.59 18 18
Ras protein signal transduction 0.017 0.025 -10000 0 -10000 0 0
IRS1 -0.007 0.12 -10000 0 -0.72 8 8
INS 0 0.001 -10000 0 -10000 0 0
LEP -0.085 0.22 -10000 0 -0.59 48 48
STAT5B -0.026 0.088 -10000 0 -0.35 7 7
STAT5A -0.026 0.088 -10000 0 -0.34 8 8
GRB2 0.013 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB -0.016 0.12 -10000 0 -0.53 12 12
CSN2 -0.043 0.082 -10000 0 -0.17 86 86
PIK3CA 0.013 0 -10000 0 -10000 0 0
LAT -0.017 0.15 -10000 0 -0.72 10 10
YBX1 0.019 0.002 -10000 0 -10000 0 0
LCK -0.032 0.17 -10000 0 -0.67 20 20
SHC1 0.013 0 -10000 0 -10000 0 0
NOX4 -0.019 0.14 -10000 0 -0.67 13 13
Fc-epsilon receptor I signaling in mast cells

Figure S43.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S43.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PPAP2A 0.011 0.034 -9999 0 -0.58 1 1
LAT2 -0.071 0.21 -9999 0 -0.68 20 20
AP1 -0.11 0.2 -9999 0 -0.7 24 24
mol:PIP3 -0.083 0.23 -9999 0 -0.7 22 22
IKBKB -0.035 0.13 -9999 0 -0.36 18 18
AKT1 -0.064 0.2 -9999 0 -0.64 17 17
IKBKG -0.036 0.13 -9999 0 -0.36 19 19
MS4A2 -0.085 0.24 -9999 0 -0.68 42 42
mol:Sphingosine-1-phosphate 0 0 -9999 0 -10000 0 0
PIK3CA 0.012 0.001 -9999 0 -10000 0 0
MAP3K1 -0.044 0.19 -9999 0 -0.6 19 19
mol:Ca2+ -0.056 0.17 -9999 0 -0.48 22 22
LYN 0.008 0.044 -9999 0 -0.76 1 1
CBLB -0.068 0.2 -9999 0 -0.65 20 20
SHC1 0.013 0 -9999 0 -10000 0 0
RasGAP/p62DOK 0.006 0.086 -9999 0 -0.43 8 8
positive regulation of cell migration 0 0 -9999 0 -10000 0 0
INPP5D -0.005 0.11 -9999 0 -0.67 8 8
PLD2 -0.098 0.23 -9999 0 -0.73 19 19
PTPN13 -0.06 0.19 -9999 0 -0.64 17 17
PTPN11 0.009 0.01 -9999 0 -10000 0 0
GO:0007205 0 0 -9999 0 -10000 0 0
regulation of mast cell degranulation -0.027 0.15 -9999 0 -0.43 15 15
SYK 0.008 0.043 -9999 0 -0.73 1 1
GRB2 0.012 0.001 -9999 0 -10000 0 0
LAT/PLCgamma1/GRB2/SLP76/GADs -0.13 0.22 -9999 0 -0.72 24 24
LAT -0.082 0.22 -9999 0 -0.64 27 27
PAK2 -0.06 0.21 -9999 0 -0.72 19 19
NFATC2 -0.11 0.25 -9999 0 -0.83 27 27
HRAS -0.076 0.24 -9999 0 -0.8 21 21
GAB2 0.008 0.06 -9999 0 -0.72 2 2
PLA2G1B 0.031 0.021 -9999 0 -10000 0 0
Fc epsilon R1 -0.15 0.26 -9999 0 -0.57 65 65
Antigen/IgE/Fc epsilon R1 -0.14 0.24 -9999 0 -0.52 68 68
mol:GDP -0.086 0.26 -9999 0 -0.84 21 21
JUN 0.011 0.034 -9999 0 -0.58 1 1
mol:Ca++ 0 0 -9999 0 -10000 0 0
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
FOS -0.033 0.17 -9999 0 -0.68 20 20
Antigen/IgE/Fc epsilon R1/LYN/SYK -0.08 0.21 -9999 0 -0.68 21 21
CHUK -0.035 0.13 -9999 0 -0.36 18 18
KLRG1 -0.079 0.2 -9999 0 -0.64 23 23
VAV1 -0.086 0.24 -9999 0 -0.77 21 21
calcium-dependent protein kinase C activity 0 0 -9999 0 -10000 0 0
CBL -0.068 0.2 -9999 0 -0.65 20 20
negative regulation of mast cell degranulation -0.075 0.2 -9999 0 -0.61 24 24
BTK -0.091 0.27 -9999 0 -0.82 25 25
Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK -0.11 0.28 -9999 0 -0.9 23 23
GAB2/PI3K/SHP2 -0.11 0.2 -9999 0 -0.71 18 18
Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP -0.072 0.21 -9999 0 -0.75 17 17
RAF1 0.021 0.025 -9999 0 -10000 0 0
Fc epsilon R1/FcgammaRIIB/SHIP -0.16 0.27 -9999 0 -0.87 25 25
FCER1G -0.009 0.13 -9999 0 -0.72 9 9
FCER1A -0.12 0.28 -9999 0 -0.69 57 57
Antigen/IgE/Fc epsilon R1/Fyn -0.13 0.23 -9999 0 -0.55 49 49
MAPK3 0.031 0.021 -9999 0 -10000 0 0
MAPK1 0.031 0.021 -9999 0 -10000 0 0
NFKB1 0.013 0 -9999 0 -10000 0 0
MAPK8 -0.002 0.076 -9999 0 -0.63 2 2
DUSP1 -0.011 0.12 -9999 0 -0.65 11 11
NF-kappa-B/RelA -0.04 0.063 -9999 0 -10000 0 0
actin cytoskeleton reorganization -0.065 0.19 -9999 0 -0.66 18 18
mol:Glucocorticoid Dexamethasone 0 0 -9999 0 -10000 0 0
PI3K -0.1 0.2 -9999 0 -0.76 18 18
FER -0.068 0.2 -9999 0 -0.65 20 20
RELA 0.013 0 -9999 0 -10000 0 0
ITK -0.077 0.18 -9999 0 -0.58 31 31
SOS1 0.013 0 -9999 0 -10000 0 0
PLCG1 -0.082 0.26 -9999 0 -0.82 22 22
cytokine secretion -0.029 0.045 -9999 0 -10000 0 0
SPHK1 -0.068 0.2 -9999 0 -0.65 20 20
PTK2 -0.069 0.2 -9999 0 -0.7 18 18
NTAL/PLCgamma1/GRB2/SLP76/GADs -0.13 0.22 -9999 0 -0.75 23 23
EDG1 0 0 -9999 0 -10000 0 0
mol:DAG -0.074 0.22 -9999 0 -0.68 20 20
MAP2K2 0.027 0.022 -9999 0 -10000 0 0
MAP2K1 0.027 0.022 -9999 0 -10000 0 0
MAP2K7 0.013 0 -9999 0 -10000 0 0
KLRG1/SHP2 -0.097 0.18 -9999 0 -0.61 22 22
MAP2K4 0.017 0.011 -9999 0 -10000 0 0
Fc epsilon R1/FcgammaRIIB -0.16 0.28 -9999 0 -0.61 58 58
mol:Choline -0.096 0.23 -9999 0 -0.72 19 19
SHC/Grb2/SOS1 -0.086 0.17 -9999 0 -0.64 17 17
FYN 0.006 0.069 -9999 0 -0.68 3 3
DOK1 0.005 0.073 -9999 0 -0.72 3 3
PXN -0.056 0.19 -9999 0 -0.64 17 17
HCLS1 -0.081 0.24 -9999 0 -0.74 25 25
PRKCB -0.063 0.18 -9999 0 -0.5 27 27
FCGR2B -0.032 0.17 -9999 0 -0.7 19 19
IGHE -0.003 0.008 -9999 0 -10000 0 0
KLRG1/SHIP -0.077 0.21 -9999 0 -0.64 23 23
LCP2 -0.009 0.12 -9999 0 -0.7 9 9
PLA2G4A -0.1 0.24 -9999 0 -0.7 29 29
RASA1 0.013 0 -9999 0 -10000 0 0
mol:Phosphatidic acid -0.096 0.23 -9999 0 -0.72 19 19
IKK complex -0.012 0.1 -9999 0 -0.29 8 8
WIPF1 0.001 0.094 -9999 0 -0.72 5 5
IL27-mediated signaling events

Figure S44.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S44.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 -0.001 0.062 -10000 0 -10000 0 0
CD4-positive alpha-beta T cell lineage commitment 0 0.001 -10000 0 -10000 0 0
cytokine production during immune response 0.056 0.17 0.6 12 -10000 0 12
IL27/IL27R/JAK1 -0.096 0.2 -10000 0 -0.81 11 11
TBX21 -0.12 0.27 -10000 0 -0.7 42 42
IL12B -0.054 0.2 -10000 0 -0.65 29 29
IL12A -0.03 0.14 -10000 0 -0.48 24 24
IL6ST -0.011 0.12 -10000 0 -0.74 8 8
IL27RA/JAK1 -0.018 0.14 -10000 0 -1.4 2 2
IL27 -0.018 0.12 -10000 0 -0.59 12 12
TYK2 0.011 0.007 -10000 0 -10000 0 0
T-helper cell lineage commitment -0.073 0.18 -10000 0 -0.78 2 2
T-helper 2 cell differentiation 0.056 0.17 0.6 12 -10000 0 12
T cell proliferation during immune response 0.056 0.17 0.6 12 -10000 0 12
MAPKKK cascade -0.056 0.17 -10000 0 -0.6 12 12
STAT3 0.013 0 -10000 0 -10000 0 0
STAT2 0.013 0 -10000 0 -10000 0 0
STAT1 0.002 0.081 -10000 0 -0.69 4 4
IL12RB1 -0.043 0.19 -10000 0 -0.7 23 23
positive regulation of tyrosine phosphorylation of STAT protein 0 0 -10000 0 -10000 0 0
IL12RB2 -0.16 0.29 -10000 0 -0.62 65 65
IL27/IL27R/JAK2/TYK2 -0.057 0.17 -10000 0 -0.62 12 12
positive regulation of T cell mediated cytotoxicity -0.056 0.17 -10000 0 -0.6 12 12
STAT1 (dimer) -0.16 0.29 0.52 2 -0.89 22 24
JAK2 0.005 0.06 -10000 0 -0.59 3 3
JAK1 0.009 0.042 -10000 0 -0.72 1 1
STAT2 (dimer) -0.048 0.16 -10000 0 -0.68 7 7
T cell proliferation -0.12 0.22 -10000 0 -0.66 23 23
IL12/IL12R/TYK2/JAK2 -0.12 0.26 -10000 0 -0.94 18 18
IL17A -0.077 0.18 -10000 0 -0.78 2 2
mast cell activation 0.056 0.17 0.6 12 -10000 0 12
IFNG -0.024 0.054 -10000 0 -0.12 57 57
T cell differentiation -0.008 0.009 -10000 0 -0.026 34 34
STAT3 (dimer) -0.048 0.16 -10000 0 -0.68 7 7
STAT5A (dimer) -0.048 0.16 -10000 0 -0.62 9 9
STAT4 (dimer) -0.062 0.19 -10000 0 -0.71 14 14
STAT4 -0.015 0.14 -10000 0 -0.69 12 12
T cell activation -0.005 0.018 0.086 10 -10000 0 10
IL27R/JAK2/TYK2 -0.039 0.15 -10000 0 -1.3 2 2
GATA3 -0.029 0.27 -10000 0 -1.5 10 10
IL18 -0.012 0.11 -10000 0 -0.55 12 12
positive regulation of mast cell cytokine production -0.047 0.16 -10000 0 -0.65 7 7
IL27/EBI3 -0.046 0.16 -10000 0 -0.5 32 32
IL27RA -0.025 0.14 -10000 0 -1.2 3 3
IL6 -0.12 0.26 -10000 0 -0.65 54 54
STAT5A 0.013 0 -10000 0 -10000 0 0
monocyte differentiation -0.001 0.003 -10000 0 -10000 0 0
IL2 0.015 0.061 0.5 2 -10000 0 2
IL1B -0.053 0.17 -10000 0 -0.5 38 38
EBI3 -0.038 0.18 -10000 0 -0.71 20 20
TNF -0.045 0.16 -10000 0 -0.5 33 33
Angiopoietin receptor Tie2-mediated signaling

Figure S45.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S45.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 0.009 0.27 -10000 0 -0.94 20 20
NCK1/PAK1/Dok-R -0.043 0.12 -10000 0 -0.44 20 20
NCK1/Dok-R -0.047 0.33 -10000 0 -1.2 20 20
PIK3CA 0.012 0.001 -10000 0 -10000 0 0
mol:beta2-estradiol 0.004 0.057 0.25 11 -10000 0 11
RELA 0.013 0 -10000 0 -10000 0 0
SHC1 0.013 0.001 -10000 0 -10000 0 0
Rac/GDP 0.009 0 -10000 0 -10000 0 0
F2 -0.037 0.17 -10000 0 -0.59 22 22
TNIP2 0.013 0 -10000 0 -10000 0 0
NF kappa B/RelA -0.085 0.27 -10000 0 -1.1 20 20
FN1 -0.098 0.25 -10000 0 -0.66 50 50
PLD2 -0.031 0.34 -10000 0 -1.2 20 20
PTPN11 0.013 0 -10000 0 -10000 0 0
GRB14 -0.12 0.27 -10000 0 -0.66 58 58
ELK1 -0.013 0.3 -10000 0 -1.1 20 20
GRB7 -0.002 0.099 -10000 0 -0.64 7 7
PAK1 0.011 0.034 -10000 0 -0.58 1 1
Tie2/Ang1/alpha5/beta1 Integrin -0.14 0.34 -10000 0 -1.2 22 22
CDKN1A 0.026 0.2 -10000 0 -0.68 14 14
ITGA5 -0.007 0.12 -10000 0 -0.72 8 8
mol:GTP 0 0 -10000 0 -10000 0 0
RasGAP/Dok-R -0.047 0.33 -10000 0 -1.2 20 20
CRK 0.013 0 -10000 0 -10000 0 0
mol:NO 0.026 0.21 -10000 0 -0.7 20 20
PLG -0.038 0.34 -10000 0 -1.2 20 20
mol:GDP 0 0 -10000 0 -10000 0 0
chemokinesis 0 0.26 -10000 0 -0.9 20 20
GRB2 0.013 0 -10000 0 -10000 0 0
PIK3R1 0.009 0.055 -10000 0 -0.66 2 2
ANGPT2 -0.015 0.22 -10000 0 -1.1 7 7
BMX -0.054 0.35 -10000 0 -1.3 20 20
ANGPT1 -0.056 0.34 -10000 0 -1.4 16 16
tube development 0.017 0.22 -10000 0 -0.69 21 21
ANGPT4 0.008 0.006 -10000 0 -10000 0 0
response to hypoxia -0.002 0.02 -10000 0 -10000 0 0
Tie2/Ang1/GRB14 -0.1 0.37 -10000 0 -1.3 20 20
alpha5/beta1 Integrin 0.003 0.094 -10000 0 -0.53 9 9
FGF2 -0.063 0.21 -10000 0 -0.64 35 35
STAT5A (dimer) 0.018 0.24 -10000 0 -0.87 14 14
mol:L-citrulline 0.026 0.21 -10000 0 -0.7 20 20
AGTR1 -0.11 0.26 -10000 0 -0.65 56 56
MAPK14 -0.024 0.33 -10000 0 -1.2 20 20
Tie2/SHP2 -0.047 0.21 -10000 0 -1.3 8 8
TEK -0.013 0.25 -10000 0 -1.5 8 8
RPS6KB1 0.011 0.26 -10000 0 -0.9 20 20
Angiotensin II/AT1 -0.081 0.2 -10000 0 -0.49 56 56
Tie2/Ang1/GRB2 -0.036 0.35 -10000 0 -1.3 20 20
MAPK3 -0.018 0.3 -10000 0 -1.1 20 20
MAPK1 -0.018 0.3 -10000 0 -1.1 20 20
Tie2/Ang1/GRB7 -0.044 0.36 -10000 0 -1.3 21 21
NFKB1 0.013 0 -10000 0 -10000 0 0
MAPK8 -0.033 0.34 -10000 0 -1.2 20 20
PI3K -0.006 0.31 -10000 0 -1.1 20 20
FES -0.025 0.33 -10000 0 -1.2 20 20
Crk/Dok-R -0.047 0.33 -10000 0 -1.2 20 20
Tie2/Ang1/ABIN2 -0.036 0.35 -10000 0 -1.3 20 20
blood circulation 0 0 -10000 0 -10000 0 0
negative regulation of caspase activity 0.016 0.24 -10000 0 -0.83 20 20
STAT5A 0.013 0.001 -10000 0 -10000 0 0
mol:ROS 0 0 -10000 0 -10000 0 0
PTK2 0.011 0.26 -10000 0 -0.9 20 20
Tie2/Ang2 -0.003 0.29 -10000 0 -0.98 20 20
Tie2/Ang1 -0.044 0.38 -10000 0 -1.4 20 20
FOXO1 0.019 0.25 -10000 0 -0.83 21 21
ELF1 0.018 0.018 -10000 0 -10000 0 0
ELF2 -0.033 0.34 -10000 0 -1.2 20 20
mol:Choline -0.026 0.32 -10000 0 -1.2 20 20
cell migration -0.036 0.072 -10000 0 -10000 0 0
FYN 0.011 0.25 -10000 0 -0.8 21 21
DOK2 -0.019 0.15 -10000 0 -0.72 13 13
negative regulation of cell cycle 0.029 0.18 -10000 0 -0.61 14 14
ETS1 0.003 0.086 -10000 0 -0.82 2 2
PXN 0.026 0.22 -10000 0 -0.73 20 20
ITGB1 0.011 0.034 -10000 0 -0.58 1 1
NOS3 0.019 0.24 -10000 0 -0.81 20 20
RAC1 0.013 0 -10000 0 -10000 0 0
TNF -0.066 0.22 -10000 0 -0.68 33 33
MAPKKK cascade -0.026 0.32 -10000 0 -1.2 20 20
RASA1 0.013 0 -10000 0 -10000 0 0
Tie2/Ang1/Shc -0.035 0.35 -10000 0 -1.3 20 20
NCK1 0.013 0 -10000 0 -10000 0 0
vasculogenesis 0.03 0.19 -10000 0 -0.62 20 20
mol:Phosphatidic acid -0.026 0.32 -10000 0 -1.2 20 20
mol:Angiotensin II 0.001 0.003 -10000 0 -10000 0 0
mol:NADP 0.026 0.21 -10000 0 -0.7 20 20
Rac1/GTP -0.067 0.21 -10000 0 -0.83 20 20
MMP2 -0.059 0.36 -10000 0 -1.3 21 21
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Figure S46.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S46.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HIF3A -0.14 0.27 -9999 0 -0.62 72 72
oxygen homeostasis 0 0 -9999 0 -10000 0 0
TCEB2 0.011 0.034 -9999 0 -0.58 1 1
TCEB1 0.011 0.034 -9999 0 -0.58 1 1
HIF1A/p53 -0.004 0.1 -9999 0 -0.38 19 19
HIF1A 0.014 0.034 -9999 0 -10000 0 0
COPS5 0.013 0 -9999 0 -10000 0 0
VHL/Elongin B/Elongin C/RBX1/CUL2 -0.003 0.038 -9999 0 -0.6 1 1
FIH (dimer) 0.013 0 -9999 0 -10000 0 0
CDKN2A -0.3 0.35 -9999 0 -0.69 137 137
ARNT/IPAS -0.095 0.2 -9999 0 -0.46 72 72
HIF1AN 0.013 0 -9999 0 -10000 0 0
GNB2L1 0.013 0 -9999 0 -10000 0 0
HIF1A/ARNT 0.021 0.033 -9999 0 -10000 0 0
CUL2 0.013 0 -9999 0 -10000 0 0
OS9 0.013 0 -9999 0 -10000 0 0
RACK1/Elongin B/Elongin C -0.002 0.039 -9999 0 -0.68 1 1
response to hypoxia 0 0 -9999 0 -10000 0 0
HIF1A/Hsp90 0.021 0.033 -9999 0 -10000 0 0
PHD1-3/OS9 -0.006 0.12 -9999 0 -0.42 22 22
HIF1A/RACK1/Elongin B/Elongin C -0.008 0.035 -9999 0 -0.51 1 1
VHL 0.013 0 -9999 0 -10000 0 0
HSP90AA1 0.013 0 -9999 0 -10000 0 0
HIF1A/JAB1 0.021 0.033 -9999 0 -10000 0 0
EGLN3 -0.051 0.2 -9999 0 -0.7 27 27
EGLN2 0.013 0 -9999 0 -10000 0 0
EGLN1 0.013 0 -9999 0 -10000 0 0
TP53 -0.034 0.18 -9999 0 -0.72 19 19
VHL/Elongin B/Elongin C/RBX1/CUL2/HIF1A 0.033 0.025 -9999 0 -10000 0 0
ARNT 0.013 0 -9999 0 -10000 0 0
ARD1A 0 0 -9999 0 -10000 0 0
RBX1 0.011 0.034 -9999 0 -0.58 1 1
HIF1A/p19ARF -0.15 0.19 -9999 0 -0.38 105 105
Nephrin/Neph1 signaling in the kidney podocyte

Figure S47.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S47.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
positive regulation of NF-kappaB transcription factor activity 0.063 0.18 0.52 36 -10000 0 36
KIRREL -0.031 0.17 -10000 0 -0.74 16 16
Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.055 0.18 -10000 0 -0.53 36 36
PLCG1 0.013 0 -10000 0 -10000 0 0
ARRB2 0.013 0 -10000 0 -10000 0 0
WASL 0.013 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/CD2AP -0.047 0.14 -10000 0 -0.51 16 16
ChemicalAbstracts:57-88-5 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.008 0.11 -10000 0 -0.53 5 5
FYN -0.032 0.14 -10000 0 -0.47 18 18
mol:Ca2+ -0.047 0.13 -10000 0 -0.5 16 16
mol:DAG -0.047 0.14 -10000 0 -0.51 16 16
NPHS2 -0.006 0.022 -10000 0 -10000 0 0
mol:IP3 -0.047 0.14 -10000 0 -0.51 16 16
regulation of endocytosis -0.023 0.13 -10000 0 -0.45 16 16
Nephrin/NEPH1/podocin/Cholesterol -0.048 0.14 -10000 0 -0.4 36 36
establishment of cell polarity -0.063 0.18 -10000 0 -0.52 36 36
Nephrin/NEPH1/podocin/NCK1-2 -0.043 0.12 -10000 0 -0.67 5 5
Nephrin/NEPH1/beta Arrestin2 -0.022 0.13 -10000 0 -0.46 16 16
NPHS1 -0.045 0.17 -10000 0 -0.6 25 25
Nephrin/NEPH1/podocin -0.038 0.13 -10000 0 -0.47 18 18
TJP1 0.013 0 -10000 0 -10000 0 0
NCK1 0.013 0 -10000 0 -10000 0 0
NCK2 0.013 0 -10000 0 -10000 0 0
heterophilic cell adhesion 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/PLCgamma1 -0.047 0.14 -10000 0 -0.51 16 16
CD2AP 0.013 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/GRB2 -0.047 0.14 -10000 0 -0.51 16 16
GRB2 0.013 0 -10000 0 -10000 0 0
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
TRPC6 -0.031 0.14 -10000 0 -0.46 20 20
cytoskeleton organization -0.01 0.13 -10000 0 -0.52 11 11
Nephrin/NEPH1 -0.04 0.14 -10000 0 -0.39 36 36
Nephrin/NEPH1/ZO-1 -0.051 0.15 -10000 0 -0.55 16 16
Osteopontin-mediated events

Figure S48.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S48.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer -0.073 0.21 -9999 0 -0.73 11 11
NF kappa B1 p50/RelA/I kappa B alpha -0.041 0.19 -9999 0 -0.67 10 10
alphaV/beta3 Integrin/Osteopontin/Src -0.12 0.21 -9999 0 -0.48 77 77
AP1 -0.082 0.24 -9999 0 -0.73 17 17
ILK -0.082 0.21 -9999 0 -0.76 10 10
bone resorption -0.049 0.2 -9999 0 -0.74 9 9
PTK2B 0.011 0.034 -9999 0 -0.58 1 1
PYK2/p130Cas -0.1 0.18 -9999 0 -0.74 9 9
ITGAV 0.008 0.073 -9999 0 -0.72 3 3
mol:GTP 0 0 -9999 0 -10000 0 0
CD44/Rho Family GTPase/ROCK2 0.013 0.056 -9999 0 -0.54 3 3
alphaV/beta3 Integrin/Osteopontin -0.13 0.22 -9999 0 -0.54 45 45
MAP3K1 -0.084 0.22 -9999 0 -0.68 14 14
JUN 0.011 0.034 -9999 0 -0.58 1 1
MAPK3 -0.071 0.21 -9999 0 -0.74 11 11
MAPK1 -0.071 0.21 -9999 0 -0.74 11 11
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
NFKB1 0.013 0 -9999 0 -10000 0 0
MAPK8 -0.074 0.21 -9999 0 -0.71 13 13
ITGB3 -0.031 0.18 -9999 0 -0.69 20 20
NFKBIA -0.059 0.21 -9999 0 -0.72 11 11
FOS -0.033 0.17 -9999 0 -0.68 20 20
CD44 0.013 0 -9999 0 -10000 0 0
CHUK 0.013 0 -9999 0 -10000 0 0
PLAU -0.061 0.25 -9999 0 -0.92 14 14
NF kappa B1 p50/RelA -0.091 0.16 -9999 0 -0.66 10 10
BCAR1 0.013 0 -9999 0 -10000 0 0
RELA 0.013 0 -9999 0 -10000 0 0
alphaV beta3 Integrin -0.038 0.15 -9999 0 -0.56 21 21
mol:GDP 0 0 -9999 0 -10000 0 0
SYK -0.085 0.22 -9999 0 -0.72 12 12
VAV3 -0.1 0.22 -9999 0 -0.72 15 15
MAP3K14 -0.086 0.22 -9999 0 -0.7 14 14
ROCK2 0.005 0.073 -9999 0 -0.72 3 3
SPP1 -0.15 0.28 -9999 0 -0.64 76 76
RAC1 0.013 0 -9999 0 -10000 0 0
Rac1/GTP -0.12 0.19 -9999 0 -0.67 14 14
MMP2 -0.083 0.24 -9999 0 -0.68 25 25
Arf6 signaling events

Figure S49.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S49.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CENTA1/KIF3B -0.027 0.11 -9999 0 -0.45 18 18
ARNO/beta Arrestin1-2 -0.035 0.11 -9999 0 -0.68 2 2
EGFR -0.019 0.14 -9999 0 -0.63 15 15
EPHA2 0.005 0.073 -9999 0 -0.72 3 3
USP6 0.013 0 -9999 0 -10000 0 0
IQSEC1 0.013 0 -9999 0 -10000 0 0
EGFR/EGFR/EGF/EGF -0.12 0.24 -9999 0 -0.5 82 82
ARRB2 0.008 0 -9999 0 -10000 0 0
mol:GTP 0.011 0.036 -9999 0 -0.15 8 8
ARRB1 0.005 0.073 -9999 0 -0.72 3 3
FBXO8 0.013 0 -9999 0 -10000 0 0
TSHR -0.05 0.19 -9999 0 -0.62 29 29
EGF -0.14 0.29 -9999 0 -0.66 70 70
somatostatin receptor activity 0 0 -9999 0 -0.001 18 18
ARAP2 0.006 0.069 -9999 0 -0.68 3 3
mol:GDP -0.042 0.098 -9999 0 -0.3 21 21
mol:PI-3-4-5-P3 0 0 -9999 0 -0.001 13 13
ITGA2B -0.021 0.14 -9999 0 -0.63 16 16
ARF6 0.013 0 -9999 0 -10000 0 0
Ephrin A1/EPHA2/NCK1/GIT1 0.027 0.049 -9999 0 -0.42 3 3
ADAP1 -0.017 0.14 -9999 0 -0.67 13 13
KIF13B -0.001 0.097 -9999 0 -0.68 6 6
HGF/MET -0.053 0.18 -9999 0 -0.5 41 41
PXN 0.013 0 -9999 0 -10000 0 0
ARF6/GTP -0.045 0.11 -9999 0 -0.31 19 19
EGFR/EGFR/EGF/EGF/ARFGEP100 -0.12 0.2 -9999 0 -0.48 46 46
ADRB2 -0.055 0.21 -9999 0 -0.72 28 28
receptor agonist activity 0 0 -9999 0 0 21 21
actin filament binding 0 0 -9999 0 -0.001 17 17
SRC 0.013 0 -9999 0 -10000 0 0
ITGB3 -0.034 0.18 -9999 0 -0.7 20 20
GNAQ 0.013 0 -9999 0 -10000 0 0
EFA6/PI-4-5-P2 0 0 -9999 0 -0.001 13 13
ARF6/GDP 0.019 0.069 -9999 0 -0.35 1 1
ARF6/GDP/GULP/ACAP1 -0.094 0.15 -9999 0 -0.47 25 25
alphaIIb/beta3 Integrin/paxillin/GIT1 -0.015 0.14 -9999 0 -0.46 21 21
ACAP1 -0.004 0.1 -9999 0 -0.64 8 8
ACAP2 0.011 0.034 -9999 0 -0.58 1 1
LHCGR/beta Arrestin2 0 0 -9999 0 -10000 0 0
EFNA1 0.011 0.034 -9999 0 -0.58 1 1
HGF -0.064 0.22 -9999 0 -0.67 34 34
CYTH3 0.011 0 -9999 0 -10000 0 0
CYTH2 0.009 0.002 -9999 0 -10000 0 0
NCK1 0.013 0 -9999 0 -10000 0 0
fibronectin binding 0 0 -9999 0 0 21 21
endosomal lumen acidification 0 0 0 3 -0.001 17 20
microtubule-based process 0 0 -9999 0 -10000 0 0
GULP1 -0.088 0.24 -9999 0 -0.65 46 46
GNAQ/ARNO 0.014 0.006 -9999 0 -10000 0 0
mol:Phosphatidic acid 0 0 -9999 0 -10000 0 0
PIP3-E 0 0 -9999 0 0 6 6
MET -0.004 0.11 -9999 0 -0.72 7 7
GNA14 -0.024 0.16 -9999 0 -0.68 16 16
GNA15 0.013 0 -9999 0 -10000 0 0
GIT1 0.013 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0 -9999 0 -0.001 15 15
GNA11 0.008 0.06 -9999 0 -0.72 2 2
LHCGR 0 0 -9999 0 -0.001 18 18
AGTR1 -0.11 0.26 -9999 0 -0.66 56 56
desensitization of G-protein coupled receptor protein signaling pathway 0 0 -9999 0 -10000 0 0
IPCEF1/ARNO -0.076 0.16 -9999 0 -0.6 3 3
alphaIIb/beta3 Integrin -0.041 0.18 -9999 0 -0.53 33 33
Integrins in angiogenesis

Figure S50.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S50.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0.008 0.076 -9999 0 -0.52 6 6
alphaV beta3 Integrin -0.078 0.2 -9999 0 -0.62 25 25
PTK2 -0.055 0.2 -9999 0 -0.7 17 17
IGF1R 0.013 0 -9999 0 -10000 0 0
PI4KB 0.013 0 -9999 0 -10000 0 0
MFGE8 0.01 0.042 -9999 0 -0.72 1 1
SRC 0.013 0 -9999 0 -10000 0 0
CDKN1B -0.059 0.16 -9999 0 -0.7 13 13
VEGFA 0.011 0.034 -9999 0 -0.58 1 1
ILK -0.059 0.16 -9999 0 -0.7 13 13
ROCK1 0.013 0 -9999 0 -10000 0 0
AKT1 -0.026 0.16 -9999 0 -0.68 12 12
PTK2B -0.002 0.14 -9999 0 -0.78 4 4
alphaV/beta3 Integrin/JAM-A -0.061 0.22 -9999 0 -0.84 12 12
CBL 0.013 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
alphaV beta3 Integrin/ANGPTL3 -0.037 0.13 -9999 0 -0.5 19 19
IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.033 0.15 -9999 0 -0.42 25 25
VEGF/Rho/ROCK/alphaV/beta3 Integrin 0 0.13 -9999 0 -0.6 8 8
alphaV/beta3 Integrin/Syndecan-1 -0.035 0.13 -9999 0 -0.52 17 17
PI4KA 0.011 0.034 -9999 0 -0.58 1 1
IGF-1R heterotetramer/IGF1/IRS1 -0.16 0.27 -9999 0 -0.81 31 31
PI4 Kinase 0.017 0.025 -9999 0 -0.42 1 1
PIK3CA 0.013 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Osteopontin -0.13 0.22 -9999 0 -0.55 44 44
RPS6KB1 -0.11 0.26 -9999 0 -0.74 31 31
TLN1 0.011 0.034 -9999 0 -0.58 1 1
MAPK3 -0.088 0.27 -9999 0 -0.87 24 24
GPR124 -0.001 0.1 -9999 0 -0.7 6 6
MAPK1 -0.088 0.27 -9999 0 -0.87 24 24
PXN 0.013 0 -9999 0 -10000 0 0
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
alphaV/beta3 Integrin/Tumstatin -0.13 0.23 -9999 0 -0.54 51 51
cell adhesion -0.035 0.13 -9999 0 -0.5 17 17
ANGPTL3 -0.002 0.059 -9999 0 -0.58 3 3
VEGFR2 homodimer/VEGFA homodimer/Src -0.009 0.062 -9999 0 -0.46 5 5
IGF-1R heterotetramer 0.013 0 -9999 0 -10000 0 0
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
TGFBR2 -0.002 0.1 -9999 0 -0.72 6 6
ITGB3 -0.034 0.18 -9999 0 -0.7 20 20
IGF1 -0.078 0.23 -9999 0 -0.64 42 42
RAC1 0.013 0 -9999 0 -10000 0 0
regulation of cell-matrix adhesion -0.042 0.15 -9999 0 -0.57 19 19
apoptosis 0.005 0.073 -9999 0 -0.72 3 3
CD47 0.013 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/CD47 -0.034 0.13 -9999 0 -0.52 17 17
VCL 0.013 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Del1 -0.09 0.22 -9999 0 -0.51 53 53
CSF1 -0.007 0.12 -9999 0 -0.72 8 8
PIK3C2A -0.059 0.16 -9999 0 -0.7 13 13
PI4 Kinase/Pyk2 -0.082 0.18 -9999 0 -0.75 13 13
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.008 0.14 -9999 0 -0.5 20 20
FAK1/Vinculin -0.035 0.16 -9999 0 -0.56 12 12
alphaV beta3/Integrin/ppsTEM5 -0.042 0.15 -9999 0 -0.58 19 19
RHOA 0.013 0 -9999 0 -10000 0 0
VTN -0.034 0.17 -9999 0 -0.66 21 21
BCAR1 0.013 0 -9999 0 -10000 0 0
FGF2 -0.062 0.21 -9999 0 -0.64 35 35
F11R -0.036 0.16 -9999 0 -0.47 36 36
alphaV/beta3 Integrin/Lactadherin -0.035 0.14 -9999 0 -0.54 17 17
alphaV/beta3 Integrin/TGFBR2 -0.042 0.15 -9999 0 -0.55 21 21
alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.016 0.085 -9999 0 -0.42 11 11
HSP90AA1 0.013 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Talin -0.009 0.13 -9999 0 -0.48 17 17
mol:GDP 0 0 -9999 0 -10000 0 0
FN1 -0.098 0.25 -9999 0 -0.66 50 50
alphaV/beta3 Integrin/Pyk2 -0.001 0.14 -9999 0 -0.79 4 4
SDC1 0.011 0.034 -9999 0 -0.58 1 1
VAV3 -0.006 0.13 -9999 0 -10000 0 0
PTPN11 0.013 0 -9999 0 -10000 0 0
IRS1 -0.007 0.12 -9999 0 -0.72 8 8
FAK1/Paxillin -0.035 0.16 -9999 0 -0.56 12 12
cell migration -0.023 0.15 -9999 0 -0.51 10 10
ITGAV 0.005 0.073 -9999 0 -0.72 3 3
PI3K -0.083 0.18 -9999 0 -0.76 12 12
SPP1 -0.15 0.29 -9999 0 -0.64 76 76
KDR 0.001 0.094 -9999 0 -0.72 5 5
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
alphaV/beta3 Integrin/Caspase 8 0.005 0.073 -9999 0 -0.72 3 3
COL4A3 -0.15 0.29 -9999 0 -0.66 74 74
angiogenesis -0.083 0.26 -9999 0 -0.85 24 24
Rac1/GTP 0.001 0.12 -9999 0 -10000 0 0
EDIL3 -0.08 0.24 -9999 0 -0.69 40 40
cell proliferation -0.042 0.15 -9999 0 -0.54 21 21
Reelin signaling pathway

Figure S51.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S51.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDK5R1/CDK5 0.01 0.069 -9999 0 -0.52 5 5
VLDLR -0.006 0.11 -9999 0 -0.69 8 8
CRKL 0.011 0.034 -9999 0 -0.58 1 1
LRPAP1 0.013 0 -9999 0 -10000 0 0
FYN 0.006 0.069 -9999 0 -0.68 3 3
ITGA3 -0.009 0.12 -9999 0 -0.72 9 9
RELN/VLDLR/Fyn -0.094 0.18 -9999 0 -0.48 35 35
MAPK8IP1/MKK7/MAP3K11/JNK1 -0.015 0.073 -9999 0 -10000 0 0
AKT1 -0.033 0.13 -9999 0 -0.57 3 3
MAP2K7 0.013 0 -9999 0 -10000 0 0
RAPGEF1 0.013 0 -9999 0 -10000 0 0
DAB1 -0.02 0.13 -9999 0 -0.58 15 15
RELN/LRP8/DAB1 -0.077 0.18 -9999 0 -0.46 33 33
LRPAP1/LRP8 0.011 0.064 -9999 0 -0.54 4 4
RELN/LRP8/DAB1/Fyn -0.091 0.16 -9999 0 -0.43 35 35
DAB1/alpha3/beta1 Integrin -0.097 0.17 -9999 0 -0.68 9 9
long-term memory -0.17 0.23 -9999 0 -0.66 29 29
DAB1/LIS1 -0.089 0.16 -9999 0 -0.63 7 7
DAB1/CRLK/C3G -0.086 0.16 -9999 0 -0.62 8 8
PIK3CA 0.013 0 -9999 0 -10000 0 0
DAB1/NCK2 -0.09 0.16 -9999 0 -0.64 7 7
ARHGEF2 0.013 0 -9999 0 -10000 0 0
mol:Src family inhibitors PP1 and PP2 0 0 -9999 0 -10000 0 0
GRIN2A -0.16 0.29 -9999 0 -0.64 82 82
CDK5R1 0.001 0.091 -9999 0 -0.7 5 5
RELN -0.12 0.26 -9999 0 -0.65 59 59
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
RELN/LRP8/Fyn -0.089 0.17 -9999 0 -0.48 32 32
GRIN2A/RELN/LRP8/DAB1/Fyn -0.18 0.22 -9999 0 -0.67 26 26
MAPK8 0.008 0.06 -9999 0 -0.72 2 2
RELN/VLDLR/DAB1 -0.082 0.19 -9999 0 -0.47 36 36
ITGB1 0.011 0.034 -9999 0 -0.58 1 1
MAP1B -0.084 0.2 -9999 0 -0.59 17 17
RELN/LRP8 -0.085 0.17 -9999 0 -0.48 30 30
GRIN2B/RELN/LRP8/DAB1/Fyn -0.099 0.17 -9999 0 -0.61 9 9
PI3K 0.016 0.041 -9999 0 -0.48 2 2
mol:PP2 0 0 -9999 0 -10000 0 0
alpha3/beta1 Integrin 0.001 0.099 -9999 0 -0.53 10 10
RAP1A -0.041 0.17 -9999 0 -0.57 8 8
PAFAH1B1 0.013 0 -9999 0 -10000 0 0
MAPK8IP1 -0.012 0.13 -9999 0 -0.67 11 11
CRLK/C3G 0.017 0.025 -9999 0 -0.42 1 1
GRIN2B -0.013 0.1 -9999 0 -0.58 9 9
NCK2 0.013 0 -9999 0 -10000 0 0
neuron differentiation -0.017 0.1 -9999 0 -0.48 3 3
neuron adhesion -0.038 0.17 -9999 0 -0.65 6 6
LRP8 0.003 0.084 -9999 0 -0.72 4 4
GSK3B -0.024 0.12 -9999 0 -0.53 3 3
RELN/VLDLR/DAB1/Fyn -0.095 0.17 -9999 0 -0.44 38 38
MAP3K11 0.013 0 -9999 0 -10000 0 0
RELN/VLDLR/DAB1/P13K -0.043 0.13 -9999 0 -0.46 8 8
CDK5 0.013 0 -9999 0 -10000 0 0
MAPT -0.064 0.2 -9999 0 -0.6 38 38
neuron migration -0.029 0.16 -9999 0 -0.55 5 5
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 -0.018 0.1 -9999 0 -0.49 3 3
RELN/VLDLR -0.061 0.18 -9999 0 -0.45 36 36
FAS signaling pathway (CD95)

Figure S52.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S52.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPTAN1 0.025 0.072 0.3 9 -10000 0 9
RFC1 0.025 0.072 0.3 9 -10000 0 9
PRKDC 0.025 0.072 0.3 9 -10000 0 9
RIPK1 0.013 0.004 -10000 0 -10000 0 0
CASP7 -0.016 0.055 0.27 1 -10000 0 1
FASLG/FAS/FADD/FAF1 -0.072 0.14 0.25 3 -0.39 37 40
MAP2K4 -0.049 0.16 -10000 0 -0.47 18 18
mol:ceramide -0.076 0.19 -10000 0 -0.56 22 22
GSN 0.025 0.072 0.3 9 -10000 0 9
FASLG/FAS/FADD/FAF1/Caspase 8 -0.065 0.16 -10000 0 -0.45 34 34
FAS 0.002 0.085 -10000 0 -0.73 4 4
BID 0.009 0.065 0.32 7 -0.43 2 9
MAP3K1 -0.012 0.098 -10000 0 -0.33 2 2
MAP3K7 0.011 0.004 -10000 0 -10000 0 0
RB1 0.021 0.079 0.3 9 -0.37 2 11
CFLAR 0.013 0.004 -10000 0 -10000 0 0
HGF/MET -0.062 0.15 -10000 0 -0.46 30 30
ARHGDIB 0.025 0.072 0.3 9 -10000 0 9
FADD -0.044 0.17 -10000 0 -0.59 28 28
actin filament polymerization -0.024 0.072 -10000 0 -0.3 9 9
NFKB1 -0.048 0.077 -10000 0 -10000 0 0
MAPK8 -0.061 0.2 -10000 0 -0.6 17 17
DFFA 0.025 0.072 0.3 9 -10000 0 9
DNA fragmentation during apoptosis 0.024 0.072 0.3 9 -10000 0 9
FAS/FADD/MET -0.033 0.14 -10000 0 -0.45 14 14
CFLAR/RIP1 0.015 0.007 -10000 0 -10000 0 0
FAIM3 -0.018 0.14 -10000 0 -0.65 14 14
FAF1 0.012 0.005 -10000 0 -10000 0 0
PARP1 0.025 0.072 0.3 9 -10000 0 9
DFFB 0.025 0.072 0.3 9 -10000 0 9
CHUK -0.041 0.068 -10000 0 -10000 0 0
FASLG -0.13 0.28 -10000 0 -0.68 60 60
FAS/FADD -0.032 0.14 -10000 0 -0.44 32 32
HGF -0.064 0.22 -10000 0 -0.67 34 34
LMNA 0.022 0.066 0.3 4 -10000 0 4
CASP6 0.025 0.072 0.3 9 -10000 0 9
CASP10 -0.001 0.094 -10000 0 -0.72 5 5
CASP3 0.03 0.088 0.37 9 -10000 0 9
PTPN13 0.005 0.073 -10000 0 -0.72 3 3
CASP8 0.017 0.077 0.36 14 -10000 0 14
IL6 -0.15 0.4 -10000 0 -1.2 30 30
MET -0.004 0.11 -10000 0 -0.72 7 7
ICAD/CAD 0.023 0.067 0.31 4 -10000 0 4
FASLG/FAS/FADD/FAF1/Caspase 10 -0.077 0.19 -10000 0 -0.57 22 22
activation of caspase activity by cytochrome c 0.009 0.065 0.31 7 -0.42 2 9
PAK2 0.024 0.072 0.3 9 -10000 0 9
BCL2 -0.037 0.17 -10000 0 -0.62 24 24
Syndecan-3-mediated signaling events

Figure S53.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S53.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN -0.025 0.14 -9999 0 -0.58 19 19
Syndecan-3/Src/Cortactin -0.1 0.16 -9999 0 -0.61 7 7
Syndecan-3/Neurocan -0.015 0.071 -9999 0 -0.69 1 1
POMC -0.092 0.23 -9999 0 -0.61 51 51
EGFR -0.019 0.14 -9999 0 -0.63 15 15
Syndecan-3/EGFR -0.019 0.081 -9999 0 -0.44 6 6
AGRP 0.004 0.006 -9999 0 -10000 0 0
NCSTN 0.013 0 -9999 0 -10000 0 0
PSENEN 0.009 0.048 -9999 0 -0.58 2 2
RP11-540L11.1 0 0 -9999 0 -10000 0 0
APH1B 0.013 0 -9999 0 -10000 0 0
APH1A 0.013 0 -9999 0 -10000 0 0
NCAN -0.016 0.12 -9999 0 -0.58 13 13
long-term memory -0.023 0.082 -9999 0 -0.46 3 3
Syndecan-3/IL8 -0.06 0.14 -9999 0 -0.4 27 27
PSEN1 0.013 0 -9999 0 -10000 0 0
Src/Cortactin -0.009 0.11 -9999 0 -0.42 19 19
FYN 0.006 0.069 -9999 0 -0.68 3 3
limb bud formation -0.003 0.041 -9999 0 -0.71 1 1
MC4R -0.018 0.12 -9999 0 -0.58 12 12
SRC 0.013 0 -9999 0 -10000 0 0
PTN -0.17 0.3 -9999 0 -0.65 86 86
FGFR/FGF/Syndecan-3 -0.003 0.042 -9999 0 -0.72 1 1
neuron projection morphogenesis -0.11 0.17 -9999 0 -0.56 16 16
Syndecan-3/AgRP -0.003 0.04 -9999 0 -0.69 1 1
Syndecan-3/AgRP/MC4R -0.014 0.066 -9999 0 -0.67 1 1
Fyn/Cortactin -0.014 0.12 -9999 0 -0.43 22 22
SDC3 -0.003 0.042 -9999 0 -0.73 1 1
GO:0007205 0 0 -9999 0 -10000 0 0
positive regulation of leukocyte migration -0.06 0.13 -9999 0 -0.4 27 27
IL8 -0.1 0.25 -9999 0 -0.66 51 51
Syndecan-3/Fyn/Cortactin -0.023 0.083 -9999 0 -0.47 3 3
Syndecan-3/CASK -0.003 0.04 -9999 0 -0.69 1 1
alpha-MSH/MC4R -0.081 0.19 -9999 0 -0.46 61 61
Gamma Secretase -0.002 0.023 -9999 0 -10000 0 0
Nongenotropic Androgen signaling

Figure S54.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S54.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.011 0 -10000 0 -10000 0 0
GNB1/GNG2 -0.057 0.17 -10000 0 -0.47 31 31
regulation of S phase of mitotic cell cycle -0.023 0.11 -10000 0 -0.37 1 1
GNAO1 0.001 0.091 -10000 0 -0.7 5 5
HRAS 0.011 0.034 -10000 0 -0.58 1 1
SHBG/T-DHT -0.008 0.062 -10000 0 -0.44 6 6
PELP1 0.013 0.001 -10000 0 -10000 0 0
AKT1 0.011 0 -10000 0 -10000 0 0
MAP2K1 -0.023 0.14 -10000 0 -0.52 2 2
T-DHT/AR -0.085 0.2 -10000 0 -0.5 56 56
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
mol:GTP 0 0.002 -10000 0 -0.006 18 18
GNAI2 0.013 0 -10000 0 -10000 0 0
GNAI3 0.013 0 -10000 0 -10000 0 0
GNAI1 0.008 0.06 -10000 0 -0.72 2 2
mol:GDP -0.079 0.17 -10000 0 -0.54 31 31
cell proliferation -0.015 0.16 -10000 0 -0.56 7 7
PIK3CA 0.013 0 -10000 0 -10000 0 0
FOS -0.022 0.2 -10000 0 -0.82 15 15
mol:Ca2+ -0.013 0.024 -10000 0 -0.091 13 13
MAPK3 -0.018 0.15 -10000 0 -0.5 7 7
MAPK1 0 0.076 -10000 0 -0.28 4 4
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
mol:IP3 0 0.001 -10000 0 -0.004 20 20
cAMP biosynthetic process 0.004 0.065 -10000 0 -0.42 6 6
GNG2 0.001 0.091 -10000 0 -0.7 5 5
potassium channel inhibitor activity 0 0.001 -10000 0 -0.004 20 20
HRAS/GTP -0.064 0.14 -10000 0 -0.39 30 30
actin cytoskeleton reorganization -0.002 0.027 -10000 0 -0.37 1 1
SRC 0.013 0.001 -10000 0 -10000 0 0
voltage-gated calcium channel activity 0 0.001 -10000 0 -0.004 20 20
PI3K -0.002 0.034 -10000 0 -0.42 2 2
apoptosis 0.008 0.13 0.44 15 -10000 0 15
T-DHT/AR/PELP1 -0.078 0.17 -10000 0 -0.42 56 56
HRAS/GDP -0.074 0.17 -10000 0 -0.52 31 31
CREB1 -0.01 0.14 -10000 0 -0.47 15 15
RAC1-CDC42/GTP -0.002 0.027 -10000 0 -0.38 1 1
AR -0.11 0.26 -10000 0 -0.66 56 56
GNB1 0.013 0 -10000 0 -10000 0 0
RAF1 -0.031 0.14 -10000 0 -0.48 4 4
RAC1-CDC42/GDP -0.069 0.16 -10000 0 -0.49 30 30
T-DHT/AR/PELP1/Src -0.053 0.16 -10000 0 -0.42 33 33
MAP2K2 -0.023 0.14 -10000 0 -0.47 4 4
T-DHT/AR/PELP1/Src/PI3K -0.023 0.11 -10000 0 -0.37 1 1
GNAZ -0.048 0.19 -10000 0 -0.62 29 29
SHBG -0.002 0.097 -10000 0 -0.68 6 6
Gi family/GNB1/GNG2/GDP -0.002 0.11 -10000 0 -0.5 6 6
mol:T-DHT 0 0.001 -10000 0 -0.003 14 14
RAC1 0.013 0 -10000 0 -10000 0 0
GNRH1 -0.016 0.11 -10000 0 -0.49 16 16
Gi family/GTP -0.029 0.11 -10000 0 -0.39 12 12
CDC42 0.013 0 -10000 0 -10000 0 0
Ras signaling in the CD4+ TCR pathway

Figure S55.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S55.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ERK1-2/ELK1 -0.023 0.21 -9999 0 -0.66 20 20
MAP3K8 0.008 0.054 -9999 0 -0.65 2 2
FOS -0.023 0.2 -9999 0 -0.68 18 18
PRKCA 0.004 0.081 -9999 0 -0.69 4 4
PTPN7 -0.035 0.18 -9999 0 -0.7 21 21
HRAS 0.011 0.034 -9999 0 -0.58 1 1
PRKCB -0.049 0.2 -9999 0 -0.68 27 27
NRAS 0.013 0.001 -9999 0 -10000 0 0
RAS family/GTP 0.024 0.021 -9999 0 -0.32 1 1
MAPK3 -0.021 0.17 -9999 0 -0.65 17 17
MAP2K1 -0.007 0.14 -9999 0 -0.48 21 21
ELK1 0.01 0.035 -9999 0 -0.58 1 1
BRAF -0.043 0.13 -9999 0 -0.49 21 21
mol:GTP 0 0.001 -9999 0 -0.005 18 18
MAPK1 -0.021 0.17 -9999 0 -0.65 17 17
RAF1 -0.043 0.13 -9999 0 -0.49 21 21
KRAS 0.013 0.001 -9999 0 -10000 0 0
ErbB4 signaling events

Figure S56.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S56.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ErbB4/ErbB4/HBEGF/HBEGF -0.008 0.1 -10000 0 -0.46 8 8
epithelial cell differentiation -0.1 0.15 -10000 0 -0.59 7 7
ITCH 0.019 0.038 -10000 0 -0.58 1 1
WWP1 0.007 0.06 -10000 0 -10000 0 0
FYN 0.006 0.069 -10000 0 -0.68 3 3
EGFR -0.019 0.14 -10000 0 -0.63 15 15
PRL -0.005 0.075 -10000 0 -0.58 5 5
neuron projection morphogenesis 0.005 0.12 -10000 0 -10000 0 0
PTPRZ1 -0.034 0.18 -10000 0 -0.72 19 19
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC -0.049 0.11 -10000 0 -10000 0 0
ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta -0.033 0.14 -10000 0 -0.46 13 13
ADAM17 0.016 0.062 -10000 0 -0.72 2 2
ErbB4/ErbB4 0 0.076 -10000 0 -10000 0 0
ErbB4/ErbB4/neuregulin 3/neuregulin 3 -0.015 0.08 -10000 0 -0.42 3 3
NCOR1 0.013 0 -10000 0 -10000 0 0
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn -0.028 0.14 -10000 0 -0.53 6 6
GRIN2B -0.032 0.15 -10000 0 -0.61 5 5
ErbB4/ErbB2/betacellulin -0.046 0.15 -10000 0 -0.48 4 4
STAT1 0.003 0.08 -10000 0 -0.69 4 4
HBEGF -0.008 0.12 -10000 0 -0.69 9 9
PRLR -0.18 0.3 -10000 0 -0.66 85 85
E4ICDs/ETO2 -0.006 0.097 -10000 0 -0.49 6 6
axon guidance 0.003 0.088 -10000 0 -0.4 2 2
NEDD4 0.021 0.016 -10000 0 -10000 0 0
Prolactin receptor/Prolactin receptor/Prolactin -0.14 0.24 -10000 0 -0.5 88 88
CBFA2T3 -0.005 0.11 -10000 0 -0.67 8 8
ErbB4/ErbB2/HBEGF 0.002 0.097 -10000 0 -0.51 1 1
MAPK3 -0.002 0.12 -10000 0 -10000 0 0
STAT1 (dimer) -0.001 0.081 -10000 0 -0.43 4 4
MAPK1 -0.002 0.12 -10000 0 -10000 0 0
JAK2 0.007 0.059 -10000 0 -0.58 3 3
ErbB4/ErbB2/neuregulin 1 beta -0.027 0.14 -10000 0 -0.48 5 5
NRG1 -0.033 0.17 -10000 0 -0.51 34 34
NRG3 -0.005 0.083 -10000 0 -0.58 6 6
NRG2 -0.061 0.21 -10000 0 -0.66 33 33
NRG4 -0.15 0.29 -10000 0 -0.67 71 71
heart development 0.003 0.088 -10000 0 -0.4 2 2
neural crest cell migration -0.027 0.14 -10000 0 -0.47 5 5
ERBB2 0.019 0.064 -10000 0 -0.47 5 5
WWOX/E4ICDs 0.003 0.069 -10000 0 -0.44 1 1
SHC1 0.013 0 -10000 0 -10000 0 0
ErbB4/EGFR/neuregulin 4 -0.1 0.19 -10000 0 -0.56 9 9
apoptosis 0.063 0.075 0.44 2 -10000 0 2
ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta -0.042 0.15 -10000 0 -0.47 22 22
ErbB4/ErbB2/epiregulin -0.15 0.2 -10000 0 -0.51 16 16
ErbB4/ErbB4/betacellulin/betacellulin -0.06 0.16 -10000 0 -0.45 31 31
ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 -0.12 0.18 -10000 0 -0.63 13 13
MDM2 0.007 0.068 -10000 0 -10000 0 0
ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta -0.052 0.12 -10000 0 -0.47 5 5
STAT5A 0.01 0.082 -10000 0 -10000 0 0
ErbB4/EGFR/neuregulin 1 beta -0.042 0.16 -10000 0 -0.56 5 5
DLG4 0.008 0.06 -10000 0 -0.72 2 2
GRB2/SHC 0.019 0 -10000 0 -10000 0 0
E4ICDs/TAB2/NCoR1 -0.022 0.046 -10000 0 -10000 0 0
STAT5A (dimer) -0.11 0.16 -10000 0 -0.65 7 7
MAP3K7IP2 0 0 -10000 0 -10000 0 0
STAT5B (dimer) 0.008 0.081 -10000 0 -10000 0 0
LRIG1 -0.015 0.14 -10000 0 -0.68 12 12
EREG -0.28 0.34 -10000 0 -0.67 127 127
BTC -0.09 0.24 -10000 0 -0.66 46 46
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta 0.003 0.088 -10000 0 -0.4 2 2
ERBB4 0 0.076 -10000 0 -10000 0 0
STAT5B 0.013 0 -10000 0 -10000 0 0
YAP1 -0.014 0.053 -10000 0 -0.45 2 2
GRB2 0.013 0 -10000 0 -10000 0 0
ErbB4/ErbB2/neuregulin 4 -0.079 0.18 -10000 0 -0.53 6 6
glial cell differentiation 0.021 0.045 -10000 0 -10000 0 0
WWOX 0.01 0.042 -10000 0 -0.72 1 1
cell proliferation -0.08 0.19 -10000 0 -0.63 14 14
Paxillin-independent events mediated by a4b1 and a4b7

Figure S57.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S57.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.012 0.14 -9999 0 -0.48 21 21
CRKL 0.011 0.034 -9999 0 -0.58 1 1
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
DOCK1 0.013 0 -9999 0 -10000 0 0
ITGA4 -0.034 0.18 -9999 0 -0.69 20 20
alpha4/beta7 Integrin/MAdCAM1 -0.018 0.14 -9999 0 -0.44 21 21
EPO -0.068 0.2 -9999 0 -0.6 39 39
alpha4/beta7 Integrin -0.029 0.16 -9999 0 -0.54 26 26
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.013 0 -9999 0 -10000 0 0
alpha4/beta1 Integrin -0.018 0.14 -9999 0 -0.51 21 21
EPO/EPOR (dimer) -0.045 0.16 -9999 0 -0.44 42 42
lamellipodium assembly 0.002 0.031 -9999 0 -0.43 1 1
PIK3CA 0.013 0 -9999 0 -10000 0 0
PI3K 0.016 0.041 -9999 0 -0.48 2 2
ARF6 0.013 0 -9999 0 -10000 0 0
JAK2 -0.029 0.14 -9999 0 -0.61 7 7
PXN 0.013 0 -9999 0 -10000 0 0
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
MADCAM1 -0.009 0.1 -9999 0 -0.58 9 9
cell adhesion -0.045 0.13 -9999 0 -0.44 21 21
CRKL/CBL 0.017 0.025 -9999 0 -0.42 1 1
ITGB1 0.011 0.034 -9999 0 -0.58 1 1
SRC -0.065 0.21 -9999 0 -0.6 27 27
ITGB7 -0.004 0.11 -9999 0 -0.72 7 7
RAC1 0.013 0 -9999 0 -10000 0 0
alpha4/beta1 Integrin/VCAM1 -0.1 0.22 -9999 0 -0.48 63 63
p130Cas/Crk/Dock1 -0.035 0.18 -9999 0 -0.7 12 12
VCAM1 -0.1 0.25 -9999 0 -0.65 54 54
RHOA 0.013 0 -9999 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin/GIT1 0.004 0.11 -9999 0 -0.42 15 15
BCAR1 -0.053 0.2 -9999 0 -0.77 12 12
EPOR 0.007 0.059 -9999 0 -0.58 3 3
mol:GDP 0 0 -9999 0 -10000 0 0
CBL 0.013 0 -9999 0 -10000 0 0
GIT1 0.013 0 -9999 0 -10000 0 0
Rac1/GTP 0.002 0.032 -9999 0 -0.44 1 1
EPHB forward signaling

Figure S58.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S58.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Ephrin A5/EPHB2 -0.058 0.17 -10000 0 -0.51 35 35
cell-cell adhesion 0.095 0.16 0.59 16 -10000 0 16
Ephrin B/EPHB2/RasGAP -0.072 0.17 -10000 0 -0.76 7 7
ITSN1 0.013 0 -10000 0 -10000 0 0
PIK3CA 0.013 0 -10000 0 -10000 0 0
SHC1 0.013 0 -10000 0 -10000 0 0
Ephrin B1/EPHB3 -0.03 0.12 -10000 0 -0.47 19 19
Ephrin B1/EPHB1 -0.061 0.14 -10000 0 -0.39 47 47
HRAS/GDP -0.078 0.15 -10000 0 -0.56 14 14
Ephrin B/EPHB1/GRB7 -0.096 0.18 -10000 0 -0.69 11 11
Endophilin/SYNJ1 -0.037 0.17 -10000 0 -0.7 7 7
KRAS 0.013 0 -10000 0 -10000 0 0
Ephrin B/EPHB1/Src -0.088 0.17 -10000 0 -0.7 9 9
endothelial cell migration -0.004 0.036 -10000 0 -0.39 2 2
GRB2 0.013 0 -10000 0 -10000 0 0
GRB7 -0.002 0.099 -10000 0 -0.64 7 7
PAK1 -0.041 0.19 -10000 0 -0.76 8 8
HRAS 0.011 0.034 -10000 0 -0.58 1 1
RRAS -0.038 0.17 -10000 0 -0.72 7 7
DNM1 -0.023 0.16 -10000 0 -0.71 15 15
cell-cell signaling 0 0 -10000 0 -10000 0 0
CRK -0.056 0.18 -10000 0 -0.67 9 9
lamellipodium assembly -0.095 0.16 -10000 0 -0.59 16 16
Ephrin B/EPHB1/Src/p52 SHC/GRB2 -0.024 0.12 -10000 0 -0.52 6 6
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
EPHB2 -0.048 0.2 -10000 0 -0.72 25 25
EPHB3 -0.031 0.17 -10000 0 -0.72 18 18
EPHB1 -0.084 0.23 -10000 0 -0.61 47 47
EPHB4 0.013 0 -10000 0 -10000 0 0
mol:GDP -0.07 0.15 -10000 0 -0.53 14 14
Ephrin B/EPHB2 -0.073 0.17 -10000 0 -0.46 42 42
Ephrin B/EPHB3 -0.065 0.16 -10000 0 -0.46 36 36
JNK cascade -0.051 0.17 -10000 0 -0.72 4 4
Ephrin B/EPHB1 -0.09 0.17 -10000 0 -0.49 31 31
RAP1/GDP -0.06 0.13 -10000 0 -0.57 4 4
EFNB2 0.01 0.042 -10000 0 -0.72 1 1
EFNB3 -0.06 0.21 -10000 0 -0.68 32 32
EFNB1 0.01 0.042 -10000 0 -0.72 1 1
Ephrin B2/EPHB1-2 -0.07 0.18 -10000 0 -0.39 70 70
RAP1B 0.009 0.048 -10000 0 -0.58 2 2
RAP1A 0.013 0 -10000 0 -10000 0 0
CDC42/GTP -0.1 0.18 -10000 0 -0.66 16 16
Rap1/GTP -0.096 0.17 -10000 0 -0.6 16 16
axon guidance -0.058 0.16 -10000 0 -0.5 35 35
MAPK3 -0.007 0.11 -10000 0 -0.49 4 4
MAPK1 -0.007 0.11 -10000 0 -0.49 4 4
Rac1/GDP -0.03 0.15 -10000 0 -0.52 9 9
actin cytoskeleton reorganization -0.074 0.13 -10000 0 -0.51 11 11
CDC42/GDP -0.03 0.15 -10000 0 -0.52 9 9
PI3K -0.004 0.036 -10000 0 -0.4 2 2
EFNA5 -0.019 0.15 -10000 0 -0.72 13 13
Ephrin B2/EPHB4 -0.002 0.027 -10000 0 -0.47 1 1
Ephrin B/EPHB2/Intersectin/N-WASP -0.024 0.14 -10000 0 -0.58 7 7
CDC42 0.013 0 -10000 0 -10000 0 0
RAS family/GTP -0.093 0.16 -10000 0 -0.59 16 16
PTK2 0.02 0.037 -10000 0 -10000 0 0
MAP4K4 -0.051 0.17 -10000 0 -0.73 4 4
SRC 0.013 0 -10000 0 -10000 0 0
KALRN -0.003 0.1 -10000 0 -0.68 7 7
Intersectin/N-WASP 0.019 0 -10000 0 -10000 0 0
neuron projection morphogenesis -0.032 0.16 -10000 0 -0.51 13 13
MAP2K1 -0.015 0.12 -10000 0 -0.48 6 6
WASL 0.013 0 -10000 0 -10000 0 0
Ephrin B1/EPHB1-2/NCK1 -0.062 0.18 -10000 0 -0.46 32 32
cell migration -0.013 0.13 -10000 0 -0.55 5 5
NRAS 0.013 0 -10000 0 -10000 0 0
SYNJ1 -0.038 0.17 -10000 0 -0.72 7 7
PXN 0.013 0 -10000 0 -10000 0 0
TF -0.16 0.23 -10000 0 -0.67 26 26
HRAS/GTP -0.1 0.18 -10000 0 -0.66 16 16
Ephrin B1/EPHB1-2 -0.07 0.18 -10000 0 -0.47 32 32
cell adhesion mediated by integrin 0.04 0.14 0.44 23 -10000 0 23
RAC1 0.013 0 -10000 0 -10000 0 0
mol:GTP -0.11 0.19 -10000 0 -0.69 16 16
RAC1-CDC42/GTP -0.11 0.19 -10000 0 -0.61 25 25
RASA1 0.013 0 -10000 0 -10000 0 0
RAC1-CDC42/GDP -0.059 0.13 -10000 0 -0.57 4 4
ruffle organization -0.053 0.19 -10000 0 -0.6 16 16
NCK1 0.013 0 -10000 0 -10000 0 0
receptor internalization -0.048 0.19 -10000 0 -0.73 11 11
Ephrin B/EPHB2/KALRN -0.081 0.18 -10000 0 -0.81 8 8
ROCK1 -0.004 0.11 -10000 0 -0.42 19 19
RAS family/GDP -0.071 0.13 -10000 0 -0.51 11 11
Rac1/GTP -0.1 0.18 -10000 0 -0.64 16 16
Ephrin B/EPHB1/Src/Paxillin -0.032 0.14 -10000 0 -0.5 9 9
Plasma membrane estrogen receptor signaling

Figure S59.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S59.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 -0.066 0.15 -10000 0 -0.45 22 22
ER alpha/Gai/GDP/Gbeta gamma -0.027 0.15 -10000 0 -0.51 17 17
AKT1 -0.035 0.21 -10000 0 -0.86 16 16
PIK3CA 0.013 0 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1/Src/PI3K -0.038 0.21 -10000 0 -0.87 16 16
mol:Ca2+ -0.025 0.17 -10000 0 -0.6 16 16
IGF1R 0.013 0 -10000 0 -10000 0 0
E2/ER alpha (dimer)/Striatin -0.06 0.14 -10000 0 -0.4 45 45
SHC1 0.013 0 -10000 0 -10000 0 0
apoptosis 0.032 0.2 0.81 16 -10000 0 16
RhoA/GTP -0.042 0.1 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1/Src/p130 Cas -0.06 0.14 -10000 0 -0.55 16 16
regulation of stress fiber formation -0.006 0.1 0.48 1 -10000 0 1
E2/ERA-ERB (dimer) -0.072 0.16 -10000 0 -0.41 53 53
KRAS 0.013 0 -10000 0 -10000 0 0
G13/GTP -0.039 0.14 -10000 0 -0.37 44 44
pseudopodium formation 0.006 0.1 -10000 0 -0.48 1 1
E2/ER alpha (dimer)/PELP1 -0.058 0.14 -10000 0 -0.4 44 44
GRB2 0.013 0 -10000 0 -10000 0 0
GNG2 0.001 0.091 -10000 0 -0.7 5 5
GNAO1 0.001 0.091 -10000 0 -0.7 5 5
HRAS 0.011 0.034 -10000 0 -0.58 1 1
mol:GTP 0 0 -10000 0 -10000 0 0
mol:NO -0.024 0.16 -10000 0 -0.59 17 17
E2/ER beta (dimer) -0.007 0.088 -10000 0 -0.48 10 10
mol:GDP -0.059 0.14 -10000 0 -0.49 20 20
mol:NADP -0.024 0.16 -10000 0 -0.59 17 17
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
mol:IP3 -0.028 0.18 -10000 0 -0.64 16 16
IGF-1R heterotetramer 0.013 0 -10000 0 -10000 0 0
PLCB1 -0.023 0.15 -10000 0 -0.59 14 14
PLCB2 -0.024 0.16 -10000 0 -0.6 12 12
IGF1 -0.078 0.23 -10000 0 -0.64 42 42
mol:L-citrulline -0.024 0.16 -10000 0 -0.59 17 17
RHOA 0.013 0 -10000 0 -10000 0 0
Gai/GDP -0.032 0.11 -10000 0 -0.81 4 4
JNK cascade -0.007 0.088 -10000 0 -0.48 10 10
BCAR1 0.013 0 -10000 0 -10000 0 0
ESR2 -0.009 0.12 -10000 0 -0.64 10 10
GNAQ 0.013 0 -10000 0 -10000 0 0
ESR1 -0.081 0.23 -10000 0 -0.64 44 44
Gq family/GDP/Gbeta gamma 0.012 0.11 -10000 0 -0.7 5 5
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 0.001 0.089 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1/Src/p52 SHC -0.06 0.14 -10000 0 -0.55 16 16
GNAZ -0.048 0.19 -10000 0 -0.62 29 29
E2/ER alpha (dimer) -0.061 0.17 -10000 0 -0.48 44 44
STRN 0.01 0.042 -10000 0 -0.72 1 1
GNAL -0.033 0.17 -10000 0 -0.68 20 20
PELP1 0.013 0 -10000 0 -10000 0 0
MAPK11 0.004 0.076 -10000 0 -0.4 10 10
GNAI2 0.013 0 -10000 0 -10000 0 0
GNAI3 0.013 0 -10000 0 -10000 0 0
GNAI1 0.008 0.06 -10000 0 -0.72 2 2
HBEGF -0.043 0.18 -10000 0 -0.68 11 11
cAMP biosynthetic process -0.08 0.16 -10000 0 -0.43 32 32
SRC -0.018 0.14 -10000 0 -0.65 6 6
PI3K 0.016 0.041 -10000 0 -0.48 2 2
GNB1 0.013 0 -10000 0 -10000 0 0
G13/GDP/Gbeta gamma -0.056 0.13 -10000 0 -0.49 16 16
SOS1 0.013 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1 -0.078 0.14 -10000 0 -0.54 10 10
Gs family/GTP -0.082 0.16 -10000 0 -0.44 32 32
EntrezGene:2778 0 0 -10000 0 -10000 0 0
RAS family/GTP 0.023 0.02 -10000 0 -0.32 1 1
vasodilation -0.022 0.15 -10000 0 -0.56 17 17
mol:DAG -0.028 0.18 -10000 0 -0.64 16 16
Gs family/GDP/Gbeta gamma -0.07 0.14 -10000 0 -0.49 19 19
MSN 0.005 0.11 -10000 0 -0.53 1 1
Gq family/GTP -0.019 0.13 -10000 0 -0.55 12 12
mol:PI-3-4-5-P3 -0.036 0.2 -10000 0 -0.83 16 16
NRAS 0.013 0 -10000 0 -10000 0 0
mol:E2 0 0 -10000 0 -10000 0 0
cell adhesion 0.022 0.15 0.56 17 -10000 0 17
GRB2/SOS1 0.019 0 -10000 0 -10000 0 0
RhoA/GDP -0.054 0.13 -10000 0 -0.48 16 16
NOS3 -0.027 0.17 -10000 0 -0.62 17 17
GNA11 0.008 0.06 -10000 0 -0.72 2 2
MAPKKK cascade -0.013 0.17 -10000 0 -0.65 17 17
E2/ER alpha (dimer)/PELP1/Src -0.064 0.14 -10000 0 -0.58 16 16
ruffle organization 0.006 0.1 -10000 0 -0.48 1 1
ROCK2 -0.003 0.12 -10000 0 -0.59 1 1
GNA14 -0.024 0.16 -10000 0 -0.68 16 16
GNA15 0.013 0 -10000 0 -10000 0 0
GNA13 0.013 0 -10000 0 -10000 0 0
MMP9 -0.044 0.18 -10000 0 -0.73 10 10
MMP2 -0.038 0.18 -10000 0 -0.6 15 15
Regulation of nuclear SMAD2/3 signaling

Figure S60.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S60.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.016 0.016 -10000 0 -10000 0 0
HSPA8 0.007 0.06 -10000 0 -0.73 2 2
SMAD3/SMAD4/ER alpha -0.053 0.16 -10000 0 -0.47 21 21
AKT1 -0.001 0.032 -10000 0 -10000 0 0
GSC -0.1 0.38 -10000 0 -1.6 17 17
NKX2-5 -0.23 0.32 -10000 0 -0.67 104 104
muscle cell differentiation 0.17 0.2 0.58 38 -10000 0 38
SMAD2-3/SMAD4/SP1 -0.001 0.11 -10000 0 -0.46 2 2
SMAD4 -0.002 0.064 -10000 0 -0.69 1 1
CBFB 0.013 0 -10000 0 -10000 0 0
SAP18 0.012 0.002 -10000 0 -10000 0 0
Cbp/p300/MSG1 0.01 0.069 -10000 0 -0.45 4 4
SMAD3/SMAD4/VDR 0.012 0.056 -10000 0 -0.46 1 1
MYC 0.027 0.033 -10000 0 -10000 0 0
CDKN2B -0.29 0.63 -10000 0 -1.5 65 65
AP1 0.011 0.11 -10000 0 -0.5 3 3
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 0.041 0.042 -10000 0 -10000 0 0
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 -0.077 0.18 -10000 0 -0.52 20 20
SP3 0.015 0.006 -10000 0 -10000 0 0
CREB1 0.013 0 -10000 0 -10000 0 0
FOXH1 -0.075 0.21 -10000 0 -0.61 38 38
SMAD3/SMAD4/GR -0.006 0.053 -10000 0 -10000 0 0
GATA3 -0.024 0.15 -10000 0 -0.68 15 15
SKI/SIN3/HDAC complex/NCoR1 0.037 0.023 -10000 0 -10000 0 0
MEF2C/TIF2 -0.19 0.25 -10000 0 -0.76 18 18
endothelial cell migration 0.13 0.45 1.4 31 -10000 0 31
MAX 0.017 0.017 -10000 0 -10000 0 0
RBBP7 0.012 0.002 -10000 0 -10000 0 0
RBBP4 0.012 0.002 -10000 0 -10000 0 0
RUNX2 0.001 0.094 -10000 0 -0.72 5 5
RUNX3 -0.021 0.15 -10000 0 -0.71 14 14
RUNX1 0.013 0 -10000 0 -10000 0 0
CTBP1 0.013 0 -10000 0 -10000 0 0
NR3C1 0.017 0.017 -10000 0 -10000 0 0
VDR 0.01 0.042 -10000 0 -0.72 1 1
CDKN1A 0.035 0.12 -10000 0 -1.3 1 1
KAT2B 0.006 0.074 -10000 0 -0.73 3 3
SMAD2/SMAD2/SMAD4/FOXH1 -0.059 0.17 -10000 0 -0.58 12 12
DCP1A 0.013 0 -10000 0 -10000 0 0
SKI 0.012 0.002 -10000 0 -10000 0 0
SERPINE1 -0.14 0.46 -10000 0 -1.5 29 29
SMAD3/SMAD4/ATF2 -0.01 0.066 -10000 0 -0.45 4 4
SMAD3/SMAD4/ATF3 -0.037 0.12 -10000 0 -0.46 19 19
SAP30 0.012 0.002 -10000 0 -10000 0 0
Cbp/p300/PIAS3 0.023 0.045 -10000 0 -10000 0 0
JUN 0.015 0.11 -10000 0 -0.53 2 2
SMAD3/SMAD4/IRF7 -0.02 0.1 -10000 0 -0.55 6 6
TFE3 0.013 0.017 -10000 0 -10000 0 0
COL1A2 -0.079 0.31 -10000 0 -0.88 34 34
mesenchymal cell differentiation 0.015 0.082 0.49 6 -10000 0 6
DLX1 -0.083 0.25 -10000 0 -0.71 40 40
TCF3 0.013 0 -10000 0 -10000 0 0
FOS -0.029 0.17 -10000 0 -0.67 20 20
SMAD3/SMAD4/Max -0.006 0.053 -10000 0 -0.4 1 1
Cbp/p300/SNIP1 0.013 0.022 -10000 0 -10000 0 0
ZBTB17 0.024 0.025 -10000 0 -10000 0 0
LAMC1 0.026 0.057 -10000 0 -10000 0 0
TGIF2/HDAC complex/SMAD3/SMAD4 -0.008 0.059 -10000 0 -0.48 1 1
IRF7 -0.004 0.1 -10000 0 -0.72 6 6
ESR1 -0.077 0.23 -10000 0 -0.62 44 44
HNF4A -0.031 0.15 -10000 0 -0.6 20 20
MEF2C -0.2 0.26 -10000 0 -0.68 30 30
SMAD2-3/SMAD4 -0.024 0.07 -10000 0 -0.4 1 1
Cbp/p300/Src-1 0.017 0.03 -10000 0 -10000 0 0
IGHV3OR16-13 -0.005 0.021 -10000 0 -10000 0 0
TGIF2/HDAC complex 0.011 0.034 -10000 0 -0.58 1 1
CREBBP 0.015 0.011 -10000 0 -10000 0 0
SKIL 0.01 0.042 -10000 0 -0.72 1 1
HDAC1 0.012 0.002 -10000 0 -10000 0 0
HDAC2 0.012 0.002 -10000 0 -10000 0 0
SNIP1 0.012 0.004 -10000 0 -10000 0 0
GCN5L2 0.002 0.014 -10000 0 -10000 0 0
SMAD3/SMAD4/TFE3 0.026 0.066 -10000 0 -0.44 1 1
MSG1/HSC70 0.002 0.084 -10000 0 -0.5 8 8
SMAD2 -0.009 0.043 -10000 0 -10000 0 0
SMAD3 0.007 0.056 -10000 0 -0.69 1 1
SMAD3/E2F4-5/DP1/p107/SMAD4 0.013 0.075 -10000 0 -0.47 1 1
SMAD2/SMAD2/SMAD4 -0.002 0.055 -10000 0 -0.42 4 4
NCOR1 0.012 0.002 -10000 0 -10000 0 0
NCOA2 0.001 0.094 -10000 0 -0.72 5 5
NCOA1 0.013 0 -10000 0 -10000 0 0
MYOD/E2A -0.085 0.2 -10000 0 -0.49 60 60
SMAD2-3/SMAD4/SP1/MIZ-1 0.007 0.11 -10000 0 -0.44 1 1
IFNB1 -0.002 0.13 -10000 0 -0.55 12 12
SMAD3/SMAD4/MEF2C -0.19 0.25 -10000 0 -0.78 17 17
CITED1 -0.001 0.094 -10000 0 -0.66 6 6
SMAD2-3/SMAD4/ARC105 0.008 0.076 -10000 0 -10000 0 0
RBL1 0.008 0.06 -10000 0 -0.72 2 2
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB -0.067 0.23 -10000 0 -0.5 63 63
RUNX1-3/PEBPB2 -0.021 0.096 -10000 0 -0.46 13 13
SMAD7 0.021 0.11 -10000 0 -10000 0 0
MYC/MIZ-1 0.034 0.064 -10000 0 -10000 0 0
SMAD3/SMAD4 0.007 0.17 0.33 8 -0.51 8 16
IL10 -0.013 0.18 -10000 0 -0.65 16 16
PIASy/HDAC complex 0.012 0.012 -10000 0 -10000 0 0
PIAS3 0.013 0.006 -10000 0 -10000 0 0
CDK2 0.015 0.01 -10000 0 -10000 0 0
IL5 -0.005 0.13 -10000 0 -0.49 12 12
CDK4 0.016 0.012 -10000 0 -10000 0 0
PIAS4 0.012 0.012 -10000 0 -10000 0 0
ATF3 -0.035 0.17 -10000 0 -0.64 22 22
SMAD3/SMAD4/SP1 0.005 0.1 -10000 0 -0.48 2 2
FOXG1 -0.15 0.28 -10000 0 -0.64 73 73
FOXO3 0.003 0.055 -10000 0 -0.6 1 1
FOXO1 0.003 0.052 -10000 0 -0.54 1 1
FOXO4 0.001 0.063 -10000 0 -0.57 2 2
heart looping -0.2 0.25 -10000 0 -0.67 30 30
CEBPB 0.006 0.016 -10000 0 -10000 0 0
SMAD3/SMAD4/DLX1 -0.068 0.17 -10000 0 -0.48 40 40
MYOD1 -0.12 0.27 -10000 0 -0.66 60 60
SMAD3/SMAD4/HNF4 -0.033 0.11 -10000 0 -0.44 7 7
SMAD3/SMAD4/GATA3 -0.036 0.13 -10000 0 -0.55 12 12
SnoN/SIN3/HDAC complex/NCoR1 0.01 0.042 -10000 0 -0.72 1 1
SMAD3/SMAD4/RUNX1-3/PEBPB2 -0.001 0.1 -10000 0 -0.44 3 3
SMAD3/SMAD4/SP1-3 0.019 0.091 -10000 0 -0.48 1 1
MED15 0.011 0.034 -10000 0 -0.58 1 1
SP1 0.002 0.046 -10000 0 -10000 0 0
SIN3B 0.012 0.002 -10000 0 -10000 0 0
SIN3A 0.012 0.002 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/NKX2-5 -0.19 0.23 -10000 0 -0.58 34 34
ITGB5 0.026 0.09 -10000 0 -0.64 1 1
TGIF/SIN3/HDAC complex/CtBP 0.045 0.008 -10000 0 -10000 0 0
SMAD3/SMAD4/AR -0.087 0.18 -10000 0 -0.5 38 38
AR -0.11 0.26 -10000 0 -0.66 56 56
negative regulation of cell growth 0.008 0.082 -10000 0 -10000 0 0
SMAD3/SMAD4/MYOD -0.096 0.18 -10000 0 -0.47 44 44
E2F5 -0.013 0.13 -10000 0 -0.69 11 11
E2F4 0.013 0 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/SMIF -0.03 0.14 -10000 0 -0.56 7 7
SMAD2-3/SMAD4/FOXO1-3a-4 -0.037 0.16 -10000 0 -0.46 6 6
TFDP1 0.011 0.034 -10000 0 -0.58 1 1
SMAD3/SMAD4/AP1 0.011 0.11 -10000 0 -0.54 2 2
SMAD3/SMAD4/RUNX2 -0.015 0.083 -10000 0 -0.49 6 6
TGIF2 0.011 0.034 -10000 0 -0.58 1 1
TGIF1 0.013 0 -10000 0 -10000 0 0
ATF2 0.008 0.06 -10000 0 -0.72 2 2
Cellular roles of Anthrax toxin

Figure S61.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S61.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ANTXR1 0.006 0.064 -10000 0 -0.63 3 3
ANTXR2 -0.011 0.13 -10000 0 -0.7 10 10
negative regulation of myeloid dendritic cell antigen processing and presentation -0.004 0.017 -10000 0 -0.086 13 13
monocyte activation -0.079 0.19 -10000 0 -0.5 42 42
MAP2K2 -0.001 0.007 -10000 0 -10000 0 0
MAP2K1 -0.003 0.015 -10000 0 -10000 0 0
MAP2K7 -0.003 0.015 -10000 0 -10000 0 0
MAP2K6 -0.02 0.081 -10000 0 -0.39 13 13
CYAA -0.002 0.08 -10000 0 -0.38 13 13
MAP2K4 -0.003 0.015 -10000 0 -10000 0 0
IL1B -0.037 0.13 -10000 0 -0.36 39 39
Channel -0.002 0.085 -10000 0 -0.4 13 13
NLRP1 -0.011 0.059 -10000 0 -0.41 6 6
CALM1 0.013 0 -10000 0 -10000 0 0
negative regulation of phagocytosis -0.004 0.02 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
regulation of endothelial cell proliferation 0.004 0.017 0.086 13 -10000 0 13
MAPK3 -0.003 0.015 -10000 0 -10000 0 0
MAPK1 -0.003 0.015 -10000 0 -10000 0 0
PGR -0.07 0.15 -10000 0 -0.38 54 54
PA/Cellular Receptors -0.019 0.089 -10000 0 -0.44 13 13
apoptosis -0.004 0.017 -10000 0 -0.086 13 13
LOC728358 0 0 -10000 0 -10000 0 0
Lethal toxin (unfolded) -0.001 0.079 -10000 0 -0.37 13 13
macrophage activation 0.015 0.016 -10000 0 -10000 0 0
TNF -0.061 0.21 -10000 0 -0.66 33 33
VCAM1 -0.08 0.19 -10000 0 -0.5 42 42
platelet activation -0.004 0.02 -10000 0 -10000 0 0
MAPKKK cascade -0.008 0.026 -10000 0 -10000 0 0
IL18 -0.007 0.093 -10000 0 -0.42 13 13
negative regulation of macrophage activation -0.004 0.017 -10000 0 -0.086 13 13
LEF -0.004 0.018 -10000 0 -0.086 13 13
CASP1 -0.007 0.032 -10000 0 -0.2 6 6
mol:cAMP -0.004 0.02 -10000 0 -10000 0 0
necrosis -0.004 0.017 -10000 0 -0.086 13 13
intracellular pH reduction 0 0 -10000 0 -10000 0 0
PAGA 0 0 -10000 0 -10000 0 0
Edema toxin (unfolded) -0.001 0.081 -10000 0 -0.38 13 13
mol:Epigallocatechin-3-gallate (EGCG) 0 0 -10000 0 -10000 0 0
Presenilin action in Notch and Wnt signaling

Figure S62.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S62.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Delta 1/NOTCH/NOTCH(cleaved) -0.025 0.11 -10000 0 -0.69 6 6
HDAC1 0.01 0.007 -10000 0 -10000 0 0
AES 0.012 0.002 -10000 0 -10000 0 0
FBXW11 0.013 0 -10000 0 -10000 0 0
DTX1 -0.003 0.1 -10000 0 -0.68 7 7
LRP6/FZD1 0.009 0.066 -10000 0 -0.42 7 7
TLE1 0.012 0.002 -10000 0 -10000 0 0
AP1 -0.011 0.11 -10000 0 -0.36 22 22
NCSTN 0.013 0 -10000 0 -10000 0 0
ADAM10 0.008 0.06 -10000 0 -0.72 2 2
Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 0.029 0.059 -10000 0 -10000 0 0
NICD/RBPSUH -0.014 0.098 -10000 0 -0.68 6 6
WIF1 -0.13 0.26 -10000 0 -0.6 69 69
NOTCH1 -0.016 0.1 -10000 0 -0.72 6 6
PSENEN 0.009 0.048 -10000 0 -0.58 2 2
KREMEN2 -0.086 0.24 -10000 0 -0.65 45 45
DKK1 -0.18 0.31 -10000 0 -0.68 85 85
beta catenin/beta TrCP1 0.025 0.053 0.31 1 -0.42 1 2
APH1B 0.013 0 -10000 0 -10000 0 0
APH1A 0.013 0 -10000 0 -10000 0 0
AXIN1 0 0.038 0.25 1 -0.28 1 2
CtBP/CBP/TCF1/TLE1/AES 0.021 0.044 -10000 0 -10000 0 0
PSEN1 0.013 0 -10000 0 -10000 0 0
FOS -0.033 0.17 -10000 0 -0.68 20 20
JUN 0.011 0.034 -10000 0 -0.58 1 1
MAP3K7 0.012 0.003 -10000 0 -10000 0 0
CTNNB1 0.019 0.056 0.33 1 -0.45 1 2
MAPK3 0.013 0 -10000 0 -10000 0 0
DKK2/LRP6/Kremen 2 -0.099 0.18 -10000 0 -0.43 70 70
HNF1A -0.004 0.099 -10000 0 -0.6 8 8
CTBP1 0.012 0.002 -10000 0 -10000 0 0
MYC 0.02 0.018 -10000 0 -10000 0 0
NKD1 -0.022 0.15 -10000 0 -0.69 15 15
FZD1 0.003 0.076 -10000 0 -0.58 5 5
NOTCH1 precursor/Deltex homolog 1 -0.021 0.12 -10000 0 -0.74 6 6
apoptosis -0.011 0.11 -10000 0 -0.36 22 22
Delta 1/NOTCHprecursor -0.023 0.11 -10000 0 -0.68 6 6
DLL1 -0.006 0.11 -10000 0 -0.69 8 8
PPARD 0.02 0.018 -10000 0 -10000 0 0
Gamma Secretase -0.001 0.024 -10000 0 -10000 0 0
APC 0 0.038 0.25 1 -0.28 1 2
DVL1 -0.01 0.026 -10000 0 -10000 0 0
CSNK2A1 0.013 0.002 -10000 0 -10000 0 0
MAP3K7IP1 -0.001 0.004 -10000 0 -10000 0 0
DKK1/LRP6/Kremen 2 -0.18 0.24 -10000 0 -0.47 117 117
LRP6 0.009 0.048 -10000 0 -0.58 2 2
CSNK1A1 0.013 0.002 -10000 0 -10000 0 0
NLK 0.014 0.008 -10000 0 -10000 0 0
CCND1 -0.028 0.24 -10000 0 -1.5 6 6
WNT1 -0.008 0.1 -10000 0 -0.58 9 9
Axin1/APC/beta catenin 0.029 0.05 0.29 1 -10000 0 1
DKK2 -0.046 0.2 -10000 0 -0.7 25 25
NOTCH1 precursor/DVL1 -0.017 0.086 -10000 0 -0.6 6 6
GSK3B 0.013 0.001 -10000 0 -10000 0 0
FRAT1 0.008 0.054 -10000 0 -0.66 2 2
NOTCH/Deltex homolog 1 -0.024 0.12 -10000 0 -0.75 6 6
PPP2R5D 0.009 0.07 0.31 15 -10000 0 15
MAPK1 0.013 0 -10000 0 -10000 0 0
WNT1/LRP6/FZD1 -0.072 0.18 -10000 0 -0.54 17 17
RBPJ 0.011 0.034 -10000 0 -0.58 1 1
CREBBP 0.015 0.004 -10000 0 -10000 0 0
IL1-mediated signaling events

Figure S63.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S63.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
UBC13/UEV1A 0.016 0.025 -9999 0 -0.42 1 1
PRKCZ 0.01 0.042 -9999 0 -0.72 1 1
MAP3K7IP2 0 0 -9999 0 -10000 0 0
ERC1 0.013 0 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 -0.026 0.074 -9999 0 -0.54 2 2
IRAK/TOLLIP 0.03 0.02 -9999 0 -10000 0 0
IKBKB 0.013 0 -9999 0 -10000 0 0
IKBKG 0.01 0.042 -9999 0 -0.72 1 1
IL1 alpha/IL1R2 -0.16 0.28 -9999 0 -0.55 98 98
IL1A -0.13 0.28 -9999 0 -0.67 65 65
IL1B -0.044 0.17 -9999 0 -0.49 39 39
IRAK/TRAF6/p62/Atypical PKCs -0.004 0.035 -9999 0 -10000 0 0
IL1R2 -0.091 0.24 -9999 0 -0.64 48 48
IL1R1 0.008 0.06 -9999 0 -0.72 2 2
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP 0.025 0.083 -9999 0 -0.53 2 2
TOLLIP 0.013 0 -9999 0 -10000 0 0
TICAM2 -0.002 0.1 -9999 0 -0.72 6 6
MAP3K3 0.013 0 -9999 0 -10000 0 0
TAK1/TAB1/TAB2 0 0 -9999 0 -10000 0 0
IKK complex/ELKS 0.061 0.035 -9999 0 -10000 0 0
JUN 0.026 0.08 -9999 0 -10000 0 0
MAP3K7 0.013 0 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/PI3K -0.048 0.12 -9999 0 -0.76 2 2
IL1 alpha/IL1R1/IL1RAP/MYD88 -0.061 0.18 -9999 0 -0.44 42 42
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 -0.081 0.16 -9999 0 -0.79 2 2
IL1 beta fragment/IL1R1/IL1RAP -0.025 0.15 -9999 0 -0.46 22 22
NFKB1 0.013 0 -9999 0 -10000 0 0
MAPK8 0.02 0.083 -9999 0 -10000 0 0
IRAK1 0.024 0.022 -9999 0 -10000 0 0
IL1RN/IL1R1 -0.027 0.14 -9999 0 -0.48 28 28
IRAK4 0.013 0 -9999 0 -10000 0 0
PRKCI 0.013 0 -9999 0 -10000 0 0
TRAF6 0.011 0.034 -9999 0 -0.58 1 1
PI3K 0.016 0.041 -9999 0 -0.48 2 2
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP 0.005 0.094 -9999 0 -0.63 2 2
CHUK 0.013 0 -9999 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88s -0.025 0.15 -9999 0 -0.46 22 22
IL1 beta/IL1R2 -0.096 0.22 -9999 0 -0.56 35 35
IRAK/TRAF6/TAK1/TAB1/TAB2 -0.002 0.022 -9999 0 -10000 0 0
NF kappa B1 p50/RelA -0.043 0.11 -9999 0 -0.68 2 2
IRAK3 -0.036 0.18 -9999 0 -0.66 22 22
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 -0.054 0.14 -9999 0 -0.76 3 3
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.03 0.13 -9999 0 -0.74 2 2
IL1 alpha/IL1R1/IL1RAP -0.096 0.19 -9999 0 -0.44 67 67
RELA 0.013 0 -9999 0 -10000 0 0
MAP3K7IP1 0 0 -9999 0 -10000 0 0
SQSTM1 0.01 0.042 -9999 0 -0.72 1 1
MYD88 0.013 0 -9999 0 -10000 0 0
IRAK/TRAF6/MEKK3 0.035 0.026 -9999 0 -10000 0 0
IL1RAP 0.008 0.054 -9999 0 -0.66 2 2
UBE2N 0.013 0 -9999 0 -10000 0 0
IRAK/TRAF6 -0.045 0.11 -9999 0 -0.62 3 3
CASP1 0.01 0.042 -9999 0 -0.72 1 1
IL1RN/IL1R2 -0.1 0.22 -9999 0 -0.49 71 71
IL1 beta fragment/IL1R1/IL1RAP/MYD88 -0.015 0.14 -9999 0 -0.79 2 2
TMEM189-UBE2V1 0.009 0.034 -9999 0 -0.58 1 1
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.009 0.11 -9999 0 -0.62 2 2
PIK3CA 0.013 0 -9999 0 -10000 0 0
IL1RN -0.044 0.18 -9999 0 -0.64 26 26
TRAF6/TAK1/TAB1/TAB2 -0.002 0.023 -9999 0 -10000 0 0
MAP2K6 0.016 0.081 -9999 0 -10000 0 0
RXR and RAR heterodimerization with other nuclear receptor

Figure S64.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S64.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.014 0.024 -9999 0 -10000 0 0
VDR 0.01 0.042 -9999 0 -0.72 1 1
FAM120B 0.013 0 -9999 0 -10000 0 0
RXRs/LXRs/DNA/9cRA -0.021 0.14 -9999 0 -0.47 7 7
RXRs/LXRs/DNA/Oxysterols -0.02 0.16 -9999 0 -0.55 8 8
MED1 0.009 0.048 -9999 0 -0.58 2 2
mol:9cRA 0.001 0.017 -9999 0 -10000 0 0
RARs/THRs/DNA/Src-1 -0.021 0.13 -9999 0 -0.47 6 6
RXRs/NUR77 -0.053 0.18 -9999 0 -0.45 28 28
RXRs/PPAR -0.052 0.15 -9999 0 -0.45 12 12
NCOR2 0.013 0 -9999 0 -10000 0 0
VDR/VDR/Vit D3 0.008 0.032 -9999 0 -0.55 1 1
RARs/VDR/DNA/Vit D3 -0.04 0.11 -9999 0 -0.4 17 17
RARA 0.013 0 -9999 0 -10000 0 0
NCOA1 0.013 0 -9999 0 -10000 0 0
VDR/VDR/DNA 0.01 0.042 -9999 0 -0.72 1 1
RARs/RARs/DNA/9cRA -0.019 0.12 -9999 0 -0.35 34 34
RARG 0.01 0.042 -9999 0 -0.72 1 1
RPS6KB1 0.022 0.039 -9999 0 -10000 0 0
RARs/THRs/DNA/SMRT -0.021 0.13 -9999 0 -0.47 6 6
THRA 0.011 0.034 -9999 0 -0.58 1 1
mol:Bile acids 0 0 -9999 0 -10000 0 0
VDR/Vit D3/DNA 0.008 0.032 -9999 0 -0.55 1 1
RXRs/PPAR/9cRA/PGJ2/DNA -0.04 0.16 -9999 0 -0.43 27 27
NR1H4 0 0.048 -9999 0 -0.58 2 2
RXRs/LXRs/DNA -0.028 0.17 -9999 0 -0.54 6 6
NR1H2 0.015 0.012 -9999 0 -10000 0 0
NR1H3 0.001 0.095 -9999 0 -0.66 6 6
RXRs/VDR/DNA/Vit D3 -0.032 0.15 -9999 0 -0.4 25 25
NR4A1 -0.023 0.14 -9999 0 -0.59 18 18
mol:ATRA 0 0 -9999 0 -10000 0 0
RXRs/FXR/9cRA/MED1 -0.016 0.096 -9999 0 -0.34 6 6
RXRG -0.1 0.25 -9999 0 -0.64 53 53
RXR alpha/CCPG 0.02 0.008 -9999 0 -10000 0 0
RXRA 0.015 0.012 -9999 0 -10000 0 0
RXRB 0.014 0.014 -9999 0 -10000 0 0
THRB -0.048 0.2 -9999 0 -0.7 26 26
PPARG -0.096 0.25 -9999 0 -0.65 50 50
PPARD 0.013 0 -9999 0 -10000 0 0
TNF -0.072 0.33 -9999 0 -1 26 26
mol:Oxysterols 0.001 0.015 -9999 0 -10000 0 0
cholesterol transport -0.019 0.16 -9999 0 -0.54 8 8
PPARA 0.013 0 -9999 0 -10000 0 0
mol:Vit D3 0 0 -9999 0 -10000 0 0
RARB -0.059 0.21 -9999 0 -0.65 33 33
RXRs/NUR77/BCL2 -0.048 0.14 -9999 0 -0.4 16 16
SREBF1 -0.01 0.16 -9999 0 -0.68 3 3
RXRs/RXRs/DNA/9cRA -0.04 0.16 -9999 0 -0.43 27 27
ABCA1 -0.017 0.19 -9999 0 -0.98 5 5
RARs/THRs -0.071 0.16 -9999 0 -0.44 38 38
RXRs/FXR -0.039 0.16 -9999 0 -0.44 25 25
BCL2 -0.037 0.17 -9999 0 -0.62 24 24
Canonical Wnt signaling pathway

Figure S65.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S65.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.006 0.023 -10000 0 -10000 0 0
AES 0.013 0.018 -10000 0 -10000 0 0
FBXW11 0.013 0 -10000 0 -10000 0 0
mol:GTP 0 0.001 -10000 0 -10000 0 0
LRP6/FZD1 0.007 0.066 -10000 0 -0.42 7 7
SMAD4 0.01 0.042 -10000 0 -0.72 1 1
DKK2 -0.046 0.2 -10000 0 -0.7 25 25
TLE1 0.012 0.016 -10000 0 -10000 0 0
MACF1 0.01 0.042 -10000 0 -0.72 1 1
CTNNB1 0.024 0.086 -10000 0 -0.44 1 1
WIF1 -0.13 0.26 -10000 0 -0.6 69 69
beta catenin/RanBP3 0.006 0.1 0.4 12 -10000 0 12
KREMEN2 -0.086 0.24 -10000 0 -0.65 45 45
DKK1 -0.18 0.31 -10000 0 -0.68 85 85
beta catenin/beta TrCP1 0.03 0.081 -10000 0 -0.4 1 1
FZD1 0.003 0.076 -10000 0 -0.58 5 5
AXIN2 -0.03 0.26 -10000 0 -1.6 8 8
AXIN1 0.013 0.001 -10000 0 -10000 0 0
RAN 0.013 0.001 -10000 0 -10000 0 0
Axin1/APC/GSK3/beta catenin 0.013 0.029 -10000 0 -10000 0 0
beta catenin/TCF/CtBP/CBP/TLE1/AES/SMAD4 0.052 0.078 -10000 0 -0.68 1 1
Axin1/APC/GSK3 0.011 0.041 0.23 1 -10000 0 1
Axin1/APC/GSK3/beta catenin/Macf1 0.037 0.062 -10000 0 -10000 0 0
HNF1A -0.011 0.099 -10000 0 -0.6 8 8
CTBP1 0.006 0.019 -10000 0 -10000 0 0
MYC 0.006 0.053 -10000 0 -10000 0 0
RANBP3 0.013 0.001 -10000 0 -10000 0 0
DKK2/LRP6/Kremen 2 -0.098 0.19 -10000 0 -0.43 70 70
NKD1 -0.022 0.15 -10000 0 -0.69 15 15
TCF4 0.003 0.047 -10000 0 -0.73 1 1
TCF3 0.005 0.018 -10000 0 -10000 0 0
WNT1/LRP6/FZD1/Axin1 -0.009 0.073 -10000 0 -10000 0 0
Ran/GTP 0.008 0.004 -10000 0 -10000 0 0
CtBP/CBP/TCF/TLE1/AES 0.02 0.11 0.47 11 -0.58 1 12
LEF1 -0.016 0.12 -10000 0 -0.7 9 9
DVL1 0.043 0.032 -10000 0 -10000 0 0
CSNK2A1 0.013 0 -10000 0 -10000 0 0
beta catenin/TCF/CtBP/CBP/TLE1/AES 0.053 0.097 -10000 0 -0.6 2 2
DKK1/LRP6/Kremen 2 -0.18 0.24 -10000 0 -0.47 117 117
LRP6 0.009 0.048 -10000 0 -0.58 2 2
CSNK1A1 0.007 0.022 -10000 0 -10000 0 0
NLK 0.013 0.004 -10000 0 -10000 0 0
CCND1 -0.038 0.25 -10000 0 -1.6 6 6
WNT1 -0.008 0.1 -10000 0 -0.58 9 9
GSK3A 0.013 0.001 -10000 0 -10000 0 0
GSK3B 0.013 0.001 -10000 0 -10000 0 0
FRAT1 0.008 0.054 -10000 0 -0.66 2 2
PPP2R5D 0.037 0.068 0.32 15 -10000 0 15
APC 0.02 0.072 -10000 0 -10000 0 0
WNT1/LRP6/FZD1 0.047 0.084 0.26 9 -10000 0 9
CREBBP 0.005 0.018 -10000 0 -10000 0 0
LPA receptor mediated events

Figure S66.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S66.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 -0.041 0.14 -9999 0 -0.59 13 13
NF kappa B1 p50/RelA/I kappa B alpha -0.024 0.083 -9999 0 -0.6 3 3
AP1 -0.065 0.16 -9999 0 -0.71 9 9
mol:PIP3 -0.052 0.14 -9999 0 -0.68 9 9
AKT1 0.023 0.11 -9999 0 -0.56 6 6
PTK2B 0.003 0.097 -9999 0 -0.47 7 7
RHOA 0.015 0.055 -9999 0 -0.5 1 1
PIK3CB 0.013 0.001 -9999 0 -10000 0 0
mol:Ca2+ 0.015 0.095 -9999 0 -0.64 3 3
MAGI3 0.011 0.034 -9999 0 -0.58 1 1
RELA 0.013 0 -9999 0 -10000 0 0
apoptosis -0.018 0.14 -9999 0 -0.48 19 19
HRAS/GDP 0.008 0.025 -9999 0 -0.43 1 1
positive regulation of microtubule depolymerization -0.025 0.14 -9999 0 -0.56 6 6
NF kappa B1 p50/RelA -0.04 0.13 -9999 0 -0.71 7 7
endothelial cell migration -0.049 0.24 -9999 0 -0.71 31 31
ADCY4 -0.021 0.17 -9999 0 -0.61 15 15
ADCY5 -0.057 0.19 -9999 0 -0.65 18 18
ADCY6 -0.026 0.18 -9999 0 -0.65 16 16
ADCY7 -0.02 0.16 -9999 0 -0.64 14 14
ADCY1 -0.029 0.17 -9999 0 -0.57 19 19
ADCY2 -0.069 0.18 -9999 0 -0.56 23 23
ADCY3 -0.018 0.15 -9999 0 -0.59 14 14
ADCY8 -0.028 0.16 -9999 0 -0.59 14 14
ADCY9 -0.018 0.15 -9999 0 -0.59 14 14
GSK3B 0.01 0.092 -9999 0 -0.5 5 5
arachidonic acid secretion -0.012 0.15 -9999 0 -0.56 14 14
GNG2 0.001 0.09 -9999 0 -0.7 5 5
TRIP6 0.019 0.023 -9999 0 -10000 0 0
GNAO1 -0.022 0.15 -9999 0 -0.56 16 16
HRAS 0.011 0.034 -9999 0 -0.58 1 1
NFKBIA 0.018 0.11 -9999 0 -0.65 4 4
GAB1 0.013 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
lamellipodium assembly -0.007 0.095 -9999 0 -0.96 3 3
JUN 0.011 0.034 -9999 0 -0.58 1 1
LPA/LPA2/NHERF2 -0.01 0.05 -9999 0 -0.45 3 3
TIAM1 -0.009 0.11 -9999 0 -1.1 3 3
PIK3R1 0.008 0.054 -9999 0 -0.65 2 2
mol:IP3 0.015 0.097 -9999 0 -0.66 3 3
PLCB3 0.017 0.049 -9999 0 -0.45 2 2
FOS -0.033 0.17 -9999 0 -0.68 20 20
positive regulation of mitosis -0.012 0.15 -9999 0 -0.56 14 14
LPA/LPA1-2-3 -0.05 0.16 -9999 0 -0.57 19 19
mol:Ca ++ 0 0 -9999 0 -10000 0 0
JNK cascade 0 0.001 -9999 0 -10000 0 0
BCAR1 0.013 0 -9999 0 -10000 0 0
stress fiber formation 0.005 0.12 -9999 0 -0.57 7 7
GNAZ -0.053 0.18 -9999 0 -0.46 39 39
EGFR/PI3K-beta/Gab1 -0.055 0.15 -9999 0 -0.74 9 9
positive regulation of dendritic cell cytokine production -0.05 0.16 -9999 0 -0.56 19 19
LPA/LPA2/MAGI-3 -0.008 0.041 -9999 0 -0.43 2 2
ARHGEF1 0.002 0.12 -9999 0 -0.51 11 11
GNAI2 -0.015 0.14 -9999 0 -0.6 11 11
GNAI3 -0.015 0.14 -9999 0 -0.6 11 11
GNAI1 -0.018 0.14 -9999 0 -0.58 13 13
LPA/LPA3 -0.026 0.1 -9999 0 -0.56 10 10
LPA/LPA2 -0.01 0.044 -9999 0 -0.58 1 1
LPA/LPA1 -0.046 0.15 -9999 0 -0.45 31 31
HB-EGF/EGFR -0.056 0.18 -9999 0 -0.44 51 51
HBEGF -0.047 0.18 -9999 0 -0.51 39 39
mol:DAG 0.015 0.097 -9999 0 -0.66 3 3
cAMP biosynthetic process -0.033 0.17 -9999 0 -0.64 15 15
NFKB1 0.013 0 -9999 0 -10000 0 0
SRC 0.013 0 -9999 0 -10000 0 0
GNB1 0.013 0.001 -9999 0 -10000 0 0
LYN 0.016 0.12 -9999 0 -0.67 5 5
GNAQ 0.003 0.09 -9999 0 -0.44 10 10
LPAR2 0.01 0.042 -9999 0 -0.72 1 1
LPAR3 -0.012 0.13 -9999 0 -0.72 10 10
LPAR1 -0.024 0.16 -9999 0 -0.79 11 11
IL8 -0.074 0.22 -9999 0 -0.53 38 38
PTK2 -0.013 0.16 -9999 0 -0.53 19 19
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
CASP3 -0.018 0.14 -9999 0 -0.48 19 19
EGFR -0.02 0.14 -9999 0 -0.63 15 15
PLCG1 0.003 0.1 -9999 0 -0.47 10 10
PLD2 -0.013 0.16 -9999 0 -0.53 19 19
G12/G13 -0.035 0.12 -9999 0 -0.55 11 11
PI3K-beta -0.033 0.11 -9999 0 -0.68 6 6
cell migration -0.015 0.053 -9999 0 -0.28 1 1
SLC9A3R2 0.008 0.054 -9999 0 -0.66 2 2
PXN 0.004 0.12 -9999 0 -0.58 7 7
HRAS/GTP -0.014 0.15 -9999 0 -0.58 14 14
RAC1 0.013 0 -9999 0 -10000 0 0
MMP9 -0.058 0.2 -9999 0 -0.65 32 32
PRKCE 0.013 0 -9999 0 -10000 0 0
PRKCD 0.022 0.092 -9999 0 -0.61 3 3
Gi(beta/gamma) -0.017 0.16 -9999 0 -0.6 14 14
mol:LPA -0.01 0.05 -9999 0 -10000 0 0
TRIP6/p130 Cas/FAK1/Paxillin -0.037 0.13 -9999 0 -0.7 7 7
MAPKKK cascade -0.012 0.15 -9999 0 -0.56 14 14
contractile ring contraction involved in cytokinesis 0.015 0.054 -9999 0 -0.49 1 1
mol:GDP 0 0 -9999 0 -10000 0 0
GNA14 -0.017 0.12 -9999 0 -0.41 22 22
GNA15 0.003 0.09 -9999 0 -0.44 10 10
GNA12 0.013 0 -9999 0 -10000 0 0
GNA13 0.013 0 -9999 0 -10000 0 0
MAPT -0.026 0.14 -9999 0 -0.58 6 6
GNA11 0 0.1 -9999 0 -0.48 11 11
Rac1/GTP -0.008 0.1 -9999 0 -1 3 3
MMP2 -0.049 0.24 -9999 0 -0.72 31 31
IL6-mediated signaling events

Figure S67.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S67.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.029 0.22 -9999 0 -0.79 6 6
CRP -0.051 0.25 -9999 0 -0.81 8 8
cell cycle arrest -0.046 0.25 -9999 0 -0.88 8 8
TIMP1 -0.024 0.22 -9999 0 -0.8 8 8
IL6ST -0.005 0.12 -9999 0 -0.72 8 8
Rac1/GDP -0.034 0.19 -9999 0 -0.61 17 17
AP1 0 0.12 -9999 0 -0.51 5 5
GAB2 0.008 0.06 -9999 0 -0.72 2 2
TNFSF11 -0.09 0.36 -9999 0 -1 27 27
HSP90B1 0.024 0.048 -9999 0 -10000 0 0
GAB1 0.013 0.002 -9999 0 -10000 0 0
MAPK14 -0.025 0.17 -9999 0 -0.64 12 12
AKT1 0.049 0.039 -9999 0 -0.48 1 1
FOXO1 0.053 0.045 -9999 0 -0.45 1 1
MAP2K6 -0.037 0.18 -9999 0 -0.58 18 18
mol:GTP 0 0.002 -9999 0 -10000 0 0
MAP2K4 -0.026 0.2 -9999 0 -0.62 16 16
MITF -0.033 0.18 -9999 0 -0.6 16 16
positive regulation of NF-kappaB transcription factor activity 0 0 -9999 0 -10000 0 0
TYK2 0.013 0 -9999 0 -10000 0 0
A2M -0.001 0.18 -9999 0 -1.5 4 4
CEBPB 0.017 0.007 -9999 0 -10000 0 0
GRB2/SOS1/GAB family/SHP2 0.006 0.08 -9999 0 -0.49 2 2
STAT3 -0.05 0.26 -9999 0 -0.95 8 8
STAT1 -0.016 0.11 -9999 0 -1.1 3 3
CEBPD -0.03 0.23 -9999 0 -0.78 7 7
PIK3CA 0.014 0 -9999 0 -10000 0 0
PI3K 0.018 0.041 -9999 0 -0.48 2 2
JUN 0.01 0.034 -9999 0 -0.58 1 1
PIAS3/MITF -0.024 0.17 -9999 0 -0.59 14 14
MAPK11 -0.025 0.17 -9999 0 -0.66 11 11
STAT3 (dimer)/FOXO1 0.004 0.22 -9999 0 -0.72 8 8
GRB2/SOS1/GAB family -0.056 0.14 -9999 0 -0.62 10 10
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.036 0.18 -9999 0 -0.63 15 15
GRB2 0.013 0.002 -9999 0 -10000 0 0
JAK2 0.007 0.059 -9999 0 -0.58 3 3
LBP -0.16 0.38 -9999 0 -0.94 43 43
PIK3R1 0.009 0.054 -9999 0 -0.66 2 2
JAK1 0.012 0.044 -9999 0 -0.74 1 1
MYC -0.028 0.22 -9999 0 -0.79 6 6
FGG -0.051 0.26 -9999 0 -0.79 13 13
macrophage differentiation -0.046 0.25 -9999 0 -0.88 8 8
IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.081 0.18 -9999 0 -0.63 15 15
JUNB -0.028 0.22 -9999 0 -0.76 6 6
FOS -0.033 0.17 -9999 0 -0.68 20 20
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.036 0.18 -9999 0 -0.58 16 16
STAT1/PIAS1 -0.032 0.17 -9999 0 -0.6 13 13
GRB2/SOS1/GAB family/SHP2/PI3K 0.035 0.043 -9999 0 -0.52 1 1
STAT3 (dimer) -0.049 0.26 -9999 0 -0.94 8 8
PRKCD -0.019 0.21 -9999 0 -0.68 12 12
IL6R 0.002 0.094 -9999 0 -0.72 5 5
SOCS3 -0.019 0.17 -9999 0 -0.82 5 5
gp130 (dimer)/JAK1/JAK1/LMO4 0.007 0.1 -9999 0 -0.44 12 12
Rac1/GTP -0.04 0.19 -9999 0 -0.63 17 17
HCK -0.007 0.12 -9999 0 -0.71 8 8
MAPKKK cascade 0.02 0.083 -9999 0 -0.72 2 2
bone resorption -0.081 0.33 -9999 0 -0.96 27 27
IRF1 -0.031 0.24 -9999 0 -0.94 6 6
mol:GDP -0.044 0.19 -9999 0 -0.62 18 18
SOS1 0.013 0.003 -9999 0 -10000 0 0
VAV1 -0.045 0.19 -9999 0 -0.64 18 18
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.026 0.16 -9999 0 -0.66 12 12
PTPN11 -0.004 0.016 -9999 0 -10000 0 0
IL6/IL6RA -0.076 0.21 -9999 0 -0.5 57 57
gp130 (dimer)/TYK2/TYK2/LMO4 0.005 0.095 -9999 0 -0.46 9 9
gp130 (dimer)/JAK2/JAK2/LMO4 0.001 0.1 -9999 0 -0.42 14 14
IL6 -0.1 0.26 -9999 0 -0.65 54 54
PIAS3 0.013 0 -9999 0 -10000 0 0
PTPRE 0.01 0.012 -9999 0 -10000 0 0
PIAS1 0.013 0 -9999 0 -10000 0 0
RAC1 0.013 0.001 -9999 0 -10000 0 0
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.042 0.16 -9999 0 -0.5 20 20
LMO4 0.003 0.084 -9999 0 -0.58 6 6
STAT3 (dimer)/PIAS3 -0.11 0.2 -9999 0 -0.85 9 9
MCL1 0.054 0.036 -9999 0 -10000 0 0
Regulation of Androgen receptor activity

Figure S68.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S68.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.019 0.033 -9999 0 -0.54 1 1
SMARCC1 0.01 0.01 -9999 0 -10000 0 0
REL 0 0.1 -9999 0 -0.72 6 6
HDAC7 -0.066 0.16 -9999 0 -0.64 10 10
JUN 0.009 0.034 -9999 0 -0.58 1 1
EP300 0.013 0.001 -9999 0 -10000 0 0
KAT2B 0.005 0.073 -9999 0 -0.72 3 3
KAT5 0.013 0.001 -9999 0 -10000 0 0
MAPK14 -0.013 0.11 -9999 0 -0.54 13 13
FOXO1 0.01 0.042 -9999 0 -0.72 1 1
T-DHT/AR -0.076 0.17 -9999 0 -0.67 11 11
MAP2K6 -0.023 0.15 -9999 0 -0.71 13 13
BRM/BAF57 0.012 0.048 -9999 0 -0.46 3 3
MAP2K4 0.007 0.007 -9999 0 -10000 0 0
SMARCA2 0.005 0.064 -9999 0 -0.63 3 3
PDE9A -0.12 0.26 -9999 0 -1.2 13 13
NCOA2 0 0.094 -9999 0 -0.72 5 5
CEBPA -0.004 0.11 -9999 0 -0.72 7 7
EHMT2 0.011 0.004 -9999 0 -10000 0 0
cell proliferation -0.053 0.16 -9999 0 -0.56 8 8
NR0B1 -0.044 0.16 -9999 0 -0.58 25 25
EGR1 0 0.087 -9999 0 -0.67 5 5
RXRs/9cRA -0.047 0.15 -9999 0 -0.42 27 27
AR/RACK1/Src -0.036 0.12 -9999 0 -0.57 6 6
AR/GR -0.04 0.14 -9999 0 -0.55 8 8
GNB2L1 0.013 0.002 -9999 0 -10000 0 0
PKN1 0.008 0.06 -9999 0 -0.72 2 2
RCHY1 0.013 0 -9999 0 -10000 0 0
epidermal growth factor receptor activity -0.001 0.002 -9999 0 -10000 0 0
MAPK8 0.006 0.048 -9999 0 -0.55 2 2
T-DHT/AR/TIF2/CARM1 -0.033 0.14 -9999 0 -0.59 12 12
SRC -0.008 0.099 -9999 0 -0.45 10 10
NR3C1 0.013 0 -9999 0 -10000 0 0
KLK3 -0.15 0.27 -9999 0 -0.88 21 21
APPBP2 0.007 0.007 -9999 0 -10000 0 0
TRIM24 0.009 0.042 -9999 0 -0.72 1 1
T-DHT/AR/TIP60 -0.034 0.13 -9999 0 -0.56 10 10
TMPRSS2 -0.42 0.52 -9999 0 -1.2 81 81
RXRG -0.1 0.25 -9999 0 -0.65 53 53
mol:9cRA -0.001 0.002 -9999 0 -10000 0 0
RXRA 0.012 0.001 -9999 0 -10000 0 0
RXRB 0.012 0.001 -9999 0 -10000 0 0
CARM1 0.012 0.003 -9999 0 -10000 0 0
NR2C2 0.01 0.042 -9999 0 -0.72 1 1
KLK2 -0.042 0.17 -9999 0 -0.61 8 8
AR -0.052 0.15 -9999 0 -0.44 25 25
SENP1 0.01 0.042 -9999 0 -0.72 1 1
HSP90AA1 0.013 0 -9999 0 -10000 0 0
MDM2 0.013 0.035 -9999 0 -0.58 1 1
SRY -0.044 0.18 -9999 0 -0.66 24 24
GATA2 0.003 0.084 -9999 0 -0.72 4 4
MYST2 0.013 0.001 -9999 0 -10000 0 0
HOXB13 -0.23 0.33 -9999 0 -0.67 107 107
T-DHT/AR/RACK1/Src -0.028 0.12 -9999 0 -0.59 6 6
positive regulation of transcription 0.003 0.084 -9999 0 -0.72 4 4
DNAJA1 0.007 0.007 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.028 0.023 -9999 0 -0.3 1 1
NCOA1 0.017 0.006 -9999 0 -10000 0 0
SPDEF -0.16 0.28 -9999 0 -0.62 81 81
T-DHT/AR/TIF2 -0.007 0.11 -9999 0 -0.54 6 6
T-DHT/AR/Hsp90 -0.035 0.13 -9999 0 -0.56 10 10
GSK3B 0.01 0.004 -9999 0 -10000 0 0
NR2C1 0.013 0.002 -9999 0 -10000 0 0
mol:T-DHT -0.017 0.11 -9999 0 -0.48 12 12
SIRT1 0.013 0.001 -9999 0 -10000 0 0
ZMIZ2 0.015 0.008 -9999 0 -10000 0 0
POU2F1 -0.005 0.06 -9999 0 -0.75 1 1
T-DHT/AR/DAX-1 -0.075 0.14 -9999 0 -0.53 14 14
CREBBP 0.012 0.001 -9999 0 -10000 0 0
SMARCE1 0.011 0.004 -9999 0 -10000 0 0
Signaling events mediated by HDAC Class III

Figure S69.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S69.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.013 0 -10000 0 -10000 0 0
HDAC4 0.013 0 -10000 0 -10000 0 0
induction of apoptosis 0 0 -10000 0 -10000 0 0
regulation of S phase of mitotic cell cycle -0.003 0.088 0.45 11 -10000 0 11
CDKN1A 0.005 0.061 -10000 0 -0.9 1 1
KAT2B 0.005 0.073 -10000 0 -0.72 3 3
BAX 0.013 0 -10000 0 -10000 0 0
FOXO3 -0.001 0.018 -10000 0 -0.31 1 1
FOXO1 0.01 0.042 -10000 0 -0.72 1 1
FOXO4 0.02 0.029 -10000 0 -0.34 2 2
response to UV 0 0 -10000 0 -10000 0 0
XRCC6 0.013 0 -10000 0 -10000 0 0
TAT 0.004 0.048 -10000 0 -0.58 2 2
mol:Lysophosphatidic acid 0 0 -10000 0 -10000 0 0
MYOD1 -0.089 0.21 -10000 0 -0.49 63 63
PPARGC1A -0.11 0.26 -10000 0 -0.65 55 55
FHL2 -0.004 0.11 -10000 0 -0.72 7 7
response to nutrient levels 0 0 -10000 0 -10000 0 0
KU70/SIRT1 0.002 0.01 -10000 0 -10000 0 0
HIST2H4A 0.003 0.088 -10000 0 -0.45 11 11
SIRT1/FOXO3a 0 0.016 -10000 0 -10000 0 0
SIRT1 0.001 0.012 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
SIRT1/MEF2D/HDAC4 0 0.009 -10000 0 -10000 0 0
SIRT1/Histone H1b -0.009 0.053 -10000 0 -10000 0 0
apoptosis 0 0.008 -10000 0 -10000 0 0
SIRT1/PGC1A -0.075 0.16 -10000 0 -0.42 55 55
p53/SIRT1 -0.033 0.14 0.42 1 -0.55 19 20
SIRT1/FOXO4 0 0.026 -10000 0 -10000 0 0
FOXO1/FHL2/SIRT1 -0.009 0.07 -10000 0 -0.43 8 8
HIST1H1E 0.007 0.066 -10000 0 -0.34 8 8
SIRT1/p300 0.002 0.01 -10000 0 -10000 0 0
muscle cell differentiation 0.085 0.17 0.46 35 -10000 0 35
TP53 -0.045 0.18 -10000 0 -0.73 19 19
KU70/SIRT1/BAX 0 0.009 -10000 0 -10000 0 0
CREBBP 0.013 0 -10000 0 -10000 0 0
MEF2D 0.013 0 -10000 0 -10000 0 0
HIV-1 Tat/SIRT1 -0.001 0.036 -10000 0 -0.42 2 2
ACSS2 0.02 0.007 -10000 0 -10000 0 0
SIRT1/PCAF/MYOD -0.085 0.17 -10000 0 -0.46 35 35
TRAIL signaling pathway

Figure S70.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S70.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TNFSF10 -0.009 0.12 -10000 0 -0.64 10 10
positive regulation of NF-kappaB transcription factor activity -0.034 0.15 -10000 0 -0.47 33 33
MAP2K4 0.018 0.075 -10000 0 -0.46 1 1
IKBKB 0.013 0 -10000 0 -10000 0 0
TNFRSF10B 0.013 0 -10000 0 -10000 0 0
TNFRSF10A 0.01 0.042 -10000 0 -0.72 1 1
SMPD1 0.009 0.068 -10000 0 -0.44 4 4
IKBKG 0.01 0.042 -10000 0 -0.72 1 1
mol:GTP 0 0 -10000 0 -10000 0 0
TNFRSF10D -0.037 0.17 -10000 0 -0.64 23 23
TRAIL/TRAILR2 0.003 0.088 -10000 0 -0.47 10 10
TRAIL/TRAILR3 -0.035 0.16 -10000 0 -0.47 33 33
TRAIL/TRAILR1 0.001 0.094 -10000 0 -0.48 11 11
TRAIL/TRAILR4 -0.034 0.15 -10000 0 -0.47 33 33
TRAIL/TRAILR1/DAP3/GTP 0.01 0.074 -10000 0 -0.43 5 5
IKK complex -0.017 0.05 -10000 0 -0.48 1 1
RIPK1 0.013 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
DAP3/GTP 0.009 0 -10000 0 -10000 0 0
MAPK3 0.006 0.089 -10000 0 -0.47 10 10
MAP3K1 0.011 0.079 -10000 0 -0.42 2 2
TRAILR4 (trimer) -0.037 0.17 -10000 0 -0.64 23 23
TRADD 0.013 0 -10000 0 -10000 0 0
TRAILR1 (trimer) 0.01 0.042 -10000 0 -0.72 1 1
TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 0.006 0.085 -10000 0 -0.53 2 2
CFLAR 0.013 0 -10000 0 -10000 0 0
MAPK1 0.006 0.089 -10000 0 -0.47 10 10
TRAIL/TRAILR1/FADD/TRADD/RIP -0.039 0.11 -10000 0 -0.51 5 5
mol:ceramide 0.009 0.068 -10000 0 -0.44 4 4
FADD -0.043 0.17 -10000 0 -0.58 28 28
MAPK8 0.022 0.084 -10000 0 -0.56 2 2
TRAF2 0.009 0.048 -10000 0 -0.58 2 2
TRAILR3 (trimer) -0.037 0.18 -10000 0 -0.64 23 23
CHUK 0.013 0 -10000 0 -10000 0 0
TRAIL/TRAILR1/FADD -0.047 0.13 -10000 0 -0.39 37 37
DAP3 0.013 0 -10000 0 -10000 0 0
CASP10 -0.027 0.14 0.29 8 -0.52 9 17
JNK cascade -0.034 0.15 -10000 0 -0.47 33 33
TRAIL (trimer) -0.009 0.12 -10000 0 -0.64 10 10
TNFRSF10C -0.037 0.18 -10000 0 -0.65 23 23
TRAIL/TRAILR1/DAP3/GTP/FADD -0.04 0.11 -10000 0 -0.52 5 5
TRAIL/TRAILR2/FADD -0.046 0.12 -10000 0 -0.55 4 4
cell death 0.009 0.067 -10000 0 -0.43 4 4
TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 0.007 0.079 -10000 0 -0.49 1 1
TRAILR2 (trimer) 0.013 0 -10000 0 -10000 0 0
CASP8 0.002 0.023 -10000 0 -10000 0 0
negative regulation of caspase activity 0 0 -10000 0 -10000 0 0
TRAIL/TRAILR2/FADD/TRADD/RIP -0.038 0.1 -10000 0 -0.69 1 1
S1P1 pathway

Figure S71.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S71.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0.004 0.076 -9999 0 -0.53 6 6
PDGFRB -0.013 0.13 -9999 0 -0.71 10 10
SPHK1 -0.015 0.024 -9999 0 -10000 0 0
mol:S1P -0.026 0.06 -9999 0 -0.41 4 4
S1P1/S1P/Gi -0.047 0.17 -9999 0 -0.57 11 11
GNAO1 -0.001 0.091 -9999 0 -0.7 5 5
PDGFB-D/PDGFRB/PLCgamma1 -0.045 0.18 -9999 0 -0.61 12 12
PLCG1 -0.041 0.17 -9999 0 -0.57 10 10
mol:GTP 0 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB -0.013 0.13 -9999 0 -0.71 10 10
GNAI2 0.011 0.006 -9999 0 -10000 0 0
GNAI3 0.011 0.006 -9999 0 -10000 0 0
GNAI1 0.006 0.06 -9999 0 -0.73 2 2
mol:GDP 0 0 -9999 0 -10000 0 0
EDG1 0.004 0.066 -9999 0 -0.46 6 6
S1P1/S1P -0.038 0.081 -9999 0 -0.42 7 7
negative regulation of cAMP metabolic process -0.045 0.17 -9999 0 -0.55 11 11
MAPK3 -0.068 0.22 -9999 0 -0.56 38 38
calcium-dependent phospholipase C activity -0.002 0.003 -9999 0 -10000 0 0
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
RhoA/GDP 0.009 0 -9999 0 -10000 0 0
KDR -0.001 0.094 -9999 0 -0.73 5 5
PLCB2 -0.013 0.12 -9999 0 -0.46 10 10
RAC1 0.013 0 -9999 0 -10000 0 0
RhoA/GTP -0.031 0.069 -9999 0 -0.36 6 6
receptor internalization -0.036 0.077 -9999 0 -0.4 7 7
PTGS2 -0.14 0.37 -9999 0 -0.98 40 40
Rac1/GTP -0.031 0.069 -9999 0 -0.36 6 6
RHOA 0.013 0 -9999 0 -10000 0 0
VEGFA 0.009 0.035 -9999 0 -0.6 1 1
negative regulation of T cell proliferation -0.045 0.17 -9999 0 -0.55 11 11
GO:0007205 0 0 -9999 0 -10000 0 0
GNAZ -0.05 0.19 -9999 0 -0.63 29 29
MAPK1 -0.068 0.22 -9999 0 -0.56 38 38
S1P1/S1P/PDGFB-D/PDGFRB -0.016 0.13 -9999 0 -0.52 10 10
ABCC1 -0.002 0.094 -9999 0 -0.61 7 7
Ephrin B reverse signaling

Figure S72.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S72.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EFNB2 0.01 0.042 -10000 0 -0.72 1 1
EPHB2 -0.048 0.2 -10000 0 -0.72 25 25
EFNB1 -0.008 0.12 -10000 0 -0.53 16 16
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP -0.087 0.18 -10000 0 -0.74 8 8
Ephrin B2/EPHB1-2 -0.081 0.17 -10000 0 -0.45 35 35
neuron projection morphogenesis -0.091 0.16 -10000 0 -0.7 8 8
Ephrin B1/EPHB1-2/Tiam1 -0.076 0.2 -10000 0 -0.8 8 8
DNM1 -0.023 0.16 -10000 0 -0.71 15 15
cell-cell signaling 0 0.002 -10000 0 -10000 0 0
MAP2K4 0.008 0.077 -10000 0 -0.75 3 3
YES1 -0.008 0.098 -10000 0 -0.99 3 3
Ephrin B1/EPHB1-2/NCK2 -0.072 0.2 -10000 0 -0.8 8 8
PI3K 0.007 0.084 -10000 0 -0.68 4 4
mol:GDP -0.094 0.19 -10000 0 -0.78 8 8
ITGA2B -0.021 0.14 -10000 0 -0.63 16 16
endothelial cell proliferation 0.003 0.028 -10000 0 -0.47 1 1
FYN -0.01 0.099 -10000 0 -0.99 3 3
MAP3K7 -0.009 0.08 -10000 0 -0.8 3 3
FGR -0.014 0.1 -10000 0 -0.98 3 3
TIAM1 0.005 0.073 -10000 0 -0.72 3 3
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
RGS3 0.013 0 -10000 0 -10000 0 0
cell adhesion -0.022 0.15 -10000 0 -0.67 6 6
LYN -0.009 0.099 -10000 0 -0.99 3 3
Ephrin B1/EPHB1-2/Src Family Kinases -0.011 0.091 -10000 0 -0.91 3 3
Ephrin B1/EPHB1-2 -0.015 0.085 -10000 0 -0.86 3 3
SRC -0.009 0.097 -10000 0 -0.98 3 3
ITGB3 -0.034 0.18 -10000 0 -0.7 20 20
EPHB1 -0.085 0.23 -10000 0 -0.61 47 47
EPHB4 0.013 0 -10000 0 -10000 0 0
RAC1 0.013 0 -10000 0 -10000 0 0
Ephrin B2/EPHB4 0.003 0.029 -10000 0 -0.47 1 1
alphaIIb/beta3 Integrin -0.041 0.18 -10000 0 -0.53 33 33
BLK -0.042 0.11 -10000 0 -0.99 3 3
HCK -0.013 0.1 -10000 0 -0.99 3 3
regulation of stress fiber formation 0.09 0.19 0.78 8 -10000 0 8
MAPK8 0.012 0.081 -10000 0 -0.71 3 3
Ephrin B1/EPHB1-2/RGS3 -0.072 0.2 -10000 0 -0.8 8 8
endothelial cell migration -0.006 0.073 -10000 0 -0.62 4 4
NCK2 0.013 0 -10000 0 -10000 0 0
PTPN13 0.004 0.086 -10000 0 -0.85 3 3
regulation of focal adhesion formation 0.09 0.19 0.78 8 -10000 0 8
chemotaxis 0.09 0.19 0.78 8 -10000 0 8
PIK3CA 0.013 0 -10000 0 -10000 0 0
Rac1/GTP -0.094 0.17 -10000 0 -0.73 8 8
angiogenesis -0.015 0.085 -10000 0 -0.86 3 3
LCK -0.018 0.1 -10000 0 -0.98 3 3
Signaling mediated by p38-gamma and p38-delta

Figure S73.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S73.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EEF2K 0.017 0.074 -9999 0 -0.46 7 7
SNTA1 0.008 0.054 -9999 0 -0.66 2 2
response to hypoxia 0 0 -9999 0 -10000 0 0
STMN1 0.016 0.077 -9999 0 -0.46 7 7
MAPK12 0.003 0.11 -9999 0 -0.48 12 12
CCND1 -0.008 0.11 -9999 0 -0.53 8 8
p38 gamma/SNTA1 0.007 0.12 -9999 0 -0.46 14 14
MAP2K3 0.01 0.042 -9999 0 -0.72 1 1
PKN1 0.008 0.06 -9999 0 -0.72 2 2
G2/M transition checkpoint 0.003 0.11 -9999 0 -0.47 12 12
MAP2K6 0.001 0.1 -9999 0 -0.45 14 14
MAPT -0.022 0.12 -9999 0 -0.36 24 24
MAPK13 0.009 0.085 -9999 0 -0.55 7 7
hyperosmotic response 0 0 -9999 0 -10000 0 0
ZAK 0.013 0.038 -9999 0 -0.36 3 3
IL2 signaling events mediated by PI3K

Figure S74.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S74.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.004 0.14 -10000 0 -0.63 6 6
UGCG 0.004 0.091 -10000 0 -0.72 4 4
AKT1/mTOR/p70S6K/Hsp90/TERT -0.005 0.15 -10000 0 -0.44 15 15
mol:GTP 0 0 -10000 0 -10000 0 0
mol:glucosylceramide 0.006 0.09 -10000 0 -0.71 4 4
mol:DAG -0.001 0.013 -10000 0 -10000 0 0
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.053 0.13 -10000 0 -0.54 12 12
FRAP1 0.004 0.19 -10000 0 -0.64 13 13
FOXO3 0.021 0.16 -10000 0 -0.55 9 9
AKT1 0.015 0.16 -10000 0 -0.59 9 9
GAB2 0.008 0.06 -10000 0 -0.72 2 2
SMPD1 0.012 0.051 -10000 0 -0.67 1 1
SGMS1 0.014 0.032 -10000 0 -10000 0 0
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
mol:GDP 0.017 0.036 -10000 0 -0.41 2 2
CALM1 0.013 0 -10000 0 -10000 0 0
cell proliferation 0.019 0.082 -10000 0 -0.41 3 3
EIF3A 0.013 0 -10000 0 -10000 0 0
PI3K 0.019 0.042 -10000 0 -0.48 2 2
RPS6KB1 -0.007 0.072 -10000 0 -0.27 2 2
mol:sphingomyelin -0.001 0.013 -10000 0 -10000 0 0
natural killer cell activation 0 0.002 -10000 0 -10000 0 0
JAK3 -0.005 0.11 -10000 0 -0.65 9 9
PIK3R1 0.011 0.054 -10000 0 -0.65 2 2
JAK1 0.013 0.042 -10000 0 -0.72 1 1
NFKB1 0.013 0 -10000 0 -10000 0 0
MYC 0.026 0.14 -10000 0 -0.56 4 4
MYB -0.098 0.32 -10000 0 -1.2 16 16
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K 0.004 0.16 -10000 0 -0.61 9 9
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.007 0.068 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 0.009 0.16 -10000 0 -0.59 9 9
Rac1/GDP 0.023 0.033 -10000 0 -0.42 1 1
T cell proliferation 0.016 0.15 -10000 0 -0.56 9 9
SHC1 0.013 0.003 -10000 0 -10000 0 0
RAC1 0.013 0 -10000 0 -10000 0 0
positive regulation of cyclin-dependent protein kinase activity -0.005 0.022 -10000 0 -0.049 56 56
PRKCZ 0.014 0.16 -10000 0 -0.58 9 9
NF kappa B1 p50/RelA -0.051 0.13 -10000 0 -0.58 9 9
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K -0.005 0.16 -10000 0 -0.57 14 14
HSP90AA1 0.013 0 -10000 0 -10000 0 0
RELA 0.013 0 -10000 0 -10000 0 0
IL2RA -0.023 0.16 -10000 0 -0.72 15 15
IL2RB -0.031 0.18 -10000 0 -0.69 20 20
TERT -0.066 0.22 -10000 0 -0.65 36 36
E2F1 -0.034 0.14 -10000 0 -0.36 31 31
SOS1 0.013 0.003 -10000 0 -10000 0 0
RPS6 0.011 0.034 -10000 0 -0.58 1 1
mol:cAMP 0.002 0.01 0.024 56 -10000 0 56
PTPN11 0.013 0.003 -10000 0 -10000 0 0
IL2RG -0.028 0.16 -10000 0 -0.63 20 20
actin cytoskeleton organization 0.016 0.15 -10000 0 -0.56 9 9
GRB2 0.013 0.003 -10000 0 -10000 0 0
IL2 0.005 0.035 -10000 0 -0.59 1 1
PIK3CA 0.015 0.003 -10000 0 -10000 0 0
Rac1/GTP 0.027 0.034 -10000 0 -0.4 1 1
LCK -0.03 0.17 -10000 0 -0.67 20 20
BCL2 -0.002 0.21 -10000 0 -0.7 17 17
HIV-1 Nef: Negative effector of Fas and TNF-alpha

Figure S75.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S75.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BAG4 0.011 0.034 -9999 0 -0.58 1 1
Caspase 8 (4 units) -0.056 0.1 -9999 0 -0.47 8 8
NEF -0.027 0.07 -9999 0 -10000 0 0
NFKBIA 0.007 0.03 -9999 0 -10000 0 0
BIRC3 -0.008 0.17 -9999 0 -0.57 25 25
CYCS -0.028 0.14 -9999 0 -0.52 8 8
RIPK1 0.013 0 -9999 0 -10000 0 0
CD247 -0.076 0.23 -9999 0 -0.81 25 25
MAP2K7 -0.018 0.11 -9999 0 -0.43 5 5
protein ubiquitination 0.013 0.1 -9999 0 -0.47 3 3
CRADD 0.013 0 -9999 0 -10000 0 0
DAXX 0.013 0 -9999 0 -10000 0 0
FAS 0.003 0.084 -9999 0 -0.72 4 4
BID -0.037 0.15 -9999 0 -0.56 8 8
NF-kappa-B/RelA/I kappa B alpha -0.022 0.075 -9999 0 -10000 0 0
TRADD 0.013 0 -9999 0 -10000 0 0
MAP3K5 0.01 0.042 -9999 0 -0.72 1 1
CFLAR 0.013 0 -9999 0 -10000 0 0
FADD -0.043 0.17 -9999 0 -0.58 28 28
NF-kappa-B/RelA/I kappa B alpha/ubiquitin -0.022 0.075 -9999 0 -10000 0 0
MAPK8 -0.012 0.12 -9999 0 -0.55 4 4
APAF1 0.013 0 -9999 0 -10000 0 0
TRAF1 -0.002 0.096 -9999 0 -0.62 7 7
TRAF2 0.009 0.048 -9999 0 -0.58 2 2
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG -0.044 0.15 -9999 0 -0.54 9 9
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP1/cIAP2/TRAF1/TRAF2/Ask1/RAIDD -0.001 0.12 -9999 0 -0.59 3 3
CHUK 0.012 0.11 -9999 0 -0.52 3 3
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 -0.033 0.1 -9999 0 -0.69 1 1
TCRz/NEF -0.11 0.23 -9999 0 -0.54 52 52
TNF -0.061 0.21 -9999 0 -0.66 33 33
FASLG -0.15 0.36 -9999 0 -0.83 62 62
NFKB1 0.007 0.03 -9999 0 -10000 0 0
TNFR1A/BAG4/TNF-alpha -0.047 0.13 -9999 0 -0.46 19 19
CASP6 -0.033 0.068 -9999 0 -10000 0 0
CASP7 -0.003 0.15 -9999 0 -0.63 5 5
RELA 0.007 0.03 -9999 0 -10000 0 0
CASP2 0.01 0.042 -9999 0 -0.72 1 1
CASP3 -0.003 0.15 -9999 0 -0.6 6 6
TNFRSF1A 0.013 0 -9999 0 -10000 0 0
TNFR1A/BAG4 0.017 0.025 -9999 0 -0.42 1 1
CASP8 0.013 0 -9999 0 -10000 0 0
CASP9 0.013 0 -9999 0 -10000 0 0
MAP3K14 0.004 0.12 -9999 0 -0.56 4 4
APAF-1/Caspase 9 -0.064 0.12 -9999 0 -0.52 9 9
BCL2 -0.028 0.15 -9999 0 -0.52 9 9
IL2 signaling events mediated by STAT5

Figure S76.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S76.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GAB2 0.009 0.06 -9999 0 -0.72 2 2
ELF1 0.002 0.084 -9999 0 -0.37 14 14
CCNA2 0.01 0.042 -9999 0 -0.72 1 1
PIK3CA 0.013 0 -9999 0 -10000 0 0
JAK3 -0.006 0.11 -9999 0 -0.65 9 9
PIK3R1 0.009 0.054 -9999 0 -0.65 2 2
JAK1 0.011 0.042 -9999 0 -0.72 1 1
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K 0.018 0.15 -9999 0 -0.66 5 5
SHC1 0.013 0 -9999 0 -10000 0 0
SP1 0.004 0.075 -9999 0 -0.37 9 9
IL2RA -0.016 0.21 -9999 0 -0.92 15 15
IL2RB -0.033 0.18 -9999 0 -0.69 20 20
SOS1 0.013 0 -9999 0 -10000 0 0
IL2RG -0.029 0.16 -9999 0 -0.63 20 20
G1/S transition of mitotic cell cycle 0.001 0.16 -9999 0 -0.67 14 14
PTPN11 0.013 0 -9999 0 -10000 0 0
CCND2 -0.008 0.18 -9999 0 -0.8 14 14
LCK -0.032 0.17 -9999 0 -0.67 20 20
GRB2 0.013 0 -9999 0 -10000 0 0
IL2 0.003 0.034 -9999 0 -0.58 1 1
CDK6 -0.001 0.097 -9999 0 -0.68 6 6
CCND3 0.028 0.13 -9999 0 -0.58 4 4
Regulation of Telomerase

Figure S77.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S77.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Telomerase catalytic core complex -0.11 0.32 -9999 0 -0.92 31 31
RAD9A 0.013 0 -9999 0 -10000 0 0
AP1 -0.018 0.13 -9999 0 -0.5 21 21
IFNAR2 0.012 0.006 -9999 0 -10000 0 0
AKT1 -0.019 0.087 -9999 0 -0.36 2 2
ER alpha/Oestrogen -0.062 0.17 -9999 0 -0.48 44 44
NFX1/SIN3/HDAC complex 0.04 0.018 -9999 0 -10000 0 0
EGF -0.14 0.29 -9999 0 -0.67 70 70
SMG5 0.013 0 -9999 0 -10000 0 0
SMG6 0.013 0 -9999 0 -10000 0 0
SP3/HDAC2 0.018 0.01 -9999 0 -10000 0 0
TERT/c-Abl -0.12 0.28 -9999 0 -0.89 28 28
SAP18 0.012 0.003 -9999 0 -10000 0 0
MRN complex 0 0 -9999 0 -10000 0 0
WT1 -0.1 0.24 -9999 0 -0.62 52 52
WRN 0.011 0.034 -9999 0 -0.58 1 1
SP1 0.013 0.008 -9999 0 -10000 0 0
SP3 0.012 0.005 -9999 0 -10000 0 0
TERF2IP 0.013 0 -9999 0 -10000 0 0
Telomerase/Nucleolin -0.11 0.24 -9999 0 -0.92 19 19
Mad/Max 0.018 0.008 -9999 0 -10000 0 0
TERT -0.11 0.34 -9999 0 -0.98 31 31
CCND1 -0.11 0.32 -9999 0 -1.1 24 24
MAX 0.012 0.005 -9999 0 -10000 0 0
RBBP7 0.012 0.003 -9999 0 -10000 0 0
RBBP4 0.012 0.003 -9999 0 -10000 0 0
TERF2 0 0 -9999 0 -10000 0 0
PTGES3 0.013 0 -9999 0 -10000 0 0
SIN3A 0.012 0.003 -9999 0 -10000 0 0
Telomerase/911 0.026 0.04 -9999 0 -10000 0 0
CDKN1B -0.068 0.19 -9999 0 -0.46 43 43
RAD1 0.011 0.034 -9999 0 -0.58 1 1
XRCC5 0.013 0 -9999 0 -10000 0 0
XRCC6 0.013 0 -9999 0 -10000 0 0
SAP30 0.012 0.003 -9999 0 -10000 0 0
TRF2/PARP2 0 0 -9999 0 -10000 0 0
UBE3A 0.012 0.005 -9999 0 -10000 0 0
JUN 0.01 0.035 -9999 0 -0.58 1 1
E6 -0.001 0.004 -9999 0 -10000 0 0
HPV-16 E6/E6AP 0.009 0.006 -9999 0 -10000 0 0
FOS -0.034 0.17 -9999 0 -0.68 20 20
IFN-gamma/IRF1 -0.093 0.22 -9999 0 -0.49 69 69
PARP2 0.013 0 -9999 0 -10000 0 0
BLM 0.013 0 -9999 0 -10000 0 0
Telomerase 0.018 0.062 -9999 0 -10000 0 0
IRF1 0.011 0.06 -9999 0 -0.72 2 2
ESR1 -0.082 0.23 -9999 0 -0.64 44 44
KU/TER 0.019 0 -9999 0 -10000 0 0
ATM/TRF2 0.02 0 -9999 0 -10000 0 0
ubiquitin-dependent protein catabolic process 0.044 0.02 -9999 0 -10000 0 0
HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex 0.044 0.02 -9999 0 -10000 0 0
HDAC1 0.012 0.003 -9999 0 -10000 0 0
HDAC2 0.012 0.008 -9999 0 -10000 0 0
ATM 0 0 -9999 0 -10000 0 0
SMAD3 0.021 0.033 -9999 0 -0.55 1 1
ABL1 0.013 0 -9999 0 -10000 0 0
MXD1 0.012 0.005 -9999 0 -10000 0 0
MRE11A 0.013 0 -9999 0 -10000 0 0
HUS1 0.011 0.034 -9999 0 -0.58 1 1
RPS6KB1 0.013 0 -9999 0 -10000 0 0
TERT/NF kappa B1/14-3-3 -0.12 0.27 -9999 0 -0.96 22 22
NR2F2 0.005 0.081 -9999 0 -0.69 4 4
MAPK3 0.012 0.026 -9999 0 -0.42 1 1
MAPK1 0.012 0.026 -9999 0 -0.42 1 1
TGFB1/TGF beta receptor Type II 0.013 0.002 -9999 0 -10000 0 0
NFKB1 0.013 0 -9999 0 -10000 0 0
HNRNPC 0.013 0 -9999 0 -10000 0 0
DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis 0 0 -9999 0 -10000 0 0
NBN 0.013 0 -9999 0 -10000 0 0
EGFR -0.02 0.14 -9999 0 -0.63 15 15
mol:Oestrogen -0.001 0.003 -9999 0 -10000 0 0
EGF/EGFR -0.12 0.24 -9999 0 -0.5 82 82
MYC 0.012 0.005 -9999 0 -10000 0 0
IL2 0.001 0.036 -9999 0 -0.58 1 1
KU 0.019 0 -9999 0 -10000 0 0
RAD50 0.013 0 -9999 0 -10000 0 0
HSP90AA1 0.013 0 -9999 0 -10000 0 0
TGFB1 0.013 0.002 -9999 0 -10000 0 0
TRF2/BLM 0 0 -9999 0 -10000 0 0
FRAP1 0 0 -9999 0 -10000 0 0
KU/TERT -0.089 0.3 -9999 0 -1 21 21
SP1/HDAC2 0.019 0.015 -9999 0 -10000 0 0
PINX1 0.013 0 -9999 0 -10000 0 0
Telomerase/EST1A -0.11 0.24 -9999 0 -0.92 19 19
Smad3/Myc 0.025 0.029 -9999 0 -0.47 1 1
911 complex -0.002 0.029 -9999 0 -10000 0 0
IFNG -0.14 0.28 -9999 0 -0.66 68 68
Telomerase/PinX1 -0.11 0.24 -9999 0 -0.92 19 19
Telomerase/AKT1/mTOR/p70S6K 0.002 0.073 -9999 0 -10000 0 0
SIN3B 0.012 0.003 -9999 0 -10000 0 0
YWHAE 0.013 0 -9999 0 -10000 0 0
Telomerase/EST1B -0.11 0.24 -9999 0 -0.92 19 19
response to DNA damage stimulus 0.003 0 -9999 0 -10000 0 0
MRN complex/TRF2/Rap1 0 0 -9999 0 -10000 0 0
TRF2/WRN -0.001 0.022 -9999 0 -0.39 1 1
Telomerase/hnRNP C1/C2 -0.11 0.24 -9999 0 -0.92 19 19
E2F1 0.002 0.078 -9999 0 -0.6 5 5
ZNFX1 0.012 0.003 -9999 0 -10000 0 0
PIF1 0.009 0.048 -9999 0 -0.58 2 2
NCL 0.013 0 -9999 0 -10000 0 0
DKC1 0.013 0 -9999 0 -10000 0 0
telomeric DNA binding 0 0 -9999 0 -10000 0 0
FOXM1 transcription factor network

Figure S78.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S78.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC3 0.18 0.32 -9999 0 -1.2 5 5
PLK1 0.093 0.067 -9999 0 -10000 0 0
BIRC5 0.081 0.16 -9999 0 -1.6 2 2
HSPA1B 0.18 0.34 -9999 0 -1.2 6 6
MAP2K1 0.048 0.033 -9999 0 -10000 0 0
BRCA2 0.17 0.36 -9999 0 -1.2 9 9
FOXM1 0.17 0.39 -9999 0 -1.7 5 5
XRCC1 0.18 0.32 -9999 0 -1.2 5 5
FOXM1B/p19 -0.12 0.29 -9999 0 -1.2 11 11
Cyclin D1/CDK4 0.14 0.36 -9999 0 -1.1 8 8
CDC2 0.18 0.34 -9999 0 -1.3 5 5
TGFA 0.15 0.36 -9999 0 -1.1 9 9
SKP2 0.18 0.32 -9999 0 -1.2 5 5
CCNE1 0.018 0.036 -9999 0 -0.6 1 1
CKS1B 0.18 0.32 -9999 0 -1.2 5 5
RB1 -0.044 0.12 -9999 0 -0.81 4 4
FOXM1C/SP1 0.17 0.34 -9999 0 -1.4 5 5
AURKB 0.088 0.12 -9999 0 -1.6 1 1
CENPF 0.18 0.33 -9999 0 -1.2 6 6
CDK4 0.026 0.014 -9999 0 -10000 0 0
MYC 0.18 0.29 -9999 0 -1 5 5
CHEK2 0.046 0.056 -9999 0 -0.74 1 1
ONECUT1 0.16 0.35 -9999 0 -1.1 8 8
CDKN2A -0.31 0.35 -9999 0 -0.69 137 137
LAMA4 0.17 0.36 -9999 0 -1.4 8 8
FOXM1B/HNF6 0.15 0.39 -9999 0 -1.4 8 8
FOS 0.14 0.42 -9999 0 -1.2 18 18
SP1 0.014 0.001 -9999 0 -10000 0 0
CDC25B 0.18 0.32 -9999 0 -1.2 5 5
response to radiation 0.031 0.031 -9999 0 -10000 0 0
CENPB 0.18 0.32 -9999 0 -1.2 5 5
CENPA 0.18 0.33 -9999 0 -1.3 5 5
NEK2 0.18 0.34 -9999 0 -1.2 6 6
HIST1H2BA 0.17 0.32 -9999 0 -1.2 5 5
CCNA2 0.018 0.044 -9999 0 -0.74 1 1
EP300 0.013 0 -9999 0 -10000 0 0
CCNB1/CDK1 0.17 0.36 -9999 0 -1.6 5 5
CCNB2 0.18 0.33 -9999 0 -1.2 5 5
CCNB1 0.18 0.34 -9999 0 -1.4 5 5
ETV5 0.17 0.35 -9999 0 -1.3 7 7
ESR1 0.12 0.45 -9999 0 -1.2 19 19
CCND1 0.15 0.37 -9999 0 -1.2 8 8
GSK3A 0.044 0.029 -9999 0 -10000 0 0
Cyclin A-E1/CDK1-2 0.056 0.054 -9999 0 -0.44 2 2
CDK2 0.02 0.008 -9999 0 -10000 0 0
G2/M transition of mitotic cell cycle 0.036 0.036 -9999 0 -10000 0 0
FOXM1B/Cbp/p300 -0.073 0.22 -9999 0 -1.4 5 5
GAS1 0.16 0.39 -9999 0 -1.3 12 12
MMP2 0.14 0.43 -9999 0 -1.3 18 18
RB1/FOXM1C 0.16 0.36 -9999 0 -1.2 8 8
CREBBP 0.013 0 -9999 0 -10000 0 0
ErbB2/ErbB3 signaling events

Figure S79.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S79.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
USP8 0.018 0.004 -9999 0 -10000 0 0
RAS family/GTP -0.016 0.094 -9999 0 -10000 0 0
NFATC4 -0.007 0.1 -9999 0 -0.48 3 3
ERBB2IP 0.013 0.002 -9999 0 -10000 0 0
HSP90 (dimer) 0.013 0 -9999 0 -10000 0 0
mammary gland morphogenesis -0.024 0.11 -9999 0 -10000 0 0
JUN -0.013 0.088 -9999 0 -0.3 12 12
HRAS 0.01 0.035 -9999 0 -0.59 1 1
DOCK7 -0.018 0.11 -9999 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta/SHC -0.037 0.13 -9999 0 -0.41 25 25
AKT1 0.011 0.003 -9999 0 -10000 0 0
BAD 0.019 0.002 -9999 0 -10000 0 0
MAPK10 -0.041 0.1 -9999 0 -0.34 6 6
mol:GTP -0.002 0.002 -9999 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta -0.024 0.12 -9999 0 -10000 0 0
RAF1 -0.02 0.1 -9999 0 -10000 0 0
ErbB2/ErbB3/neuregulin 2 -0.052 0.14 -9999 0 -0.39 40 40
STAT3 0.001 0.002 -9999 0 -10000 0 0
cell migration -0.003 0.081 -9999 0 -0.29 1 1
mol:PI-3-4-5-P3 0 0.002 -9999 0 -10000 0 0
cell proliferation -0.17 0.27 -9999 0 -0.6 63 63
FOS -0.1 0.19 -9999 0 -0.48 22 22
NRAS 0.012 0.001 -9999 0 -10000 0 0
mol:Ca2+ -0.024 0.11 -9999 0 -10000 0 0
MAPK3 -0.13 0.22 -9999 0 -0.6 9 9
MAPK1 -0.13 0.22 -9999 0 -0.6 9 9
JAK2 -0.02 0.11 -9999 0 -10000 0 0
NF2 -0.004 0.032 -9999 0 -0.39 2 2
ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 -0.014 0.1 -9999 0 -0.33 25 25
NRG1 -0.061 0.21 -9999 0 -0.68 32 32
GRB2/SOS1 0.01 0.01 -9999 0 -10000 0 0
MAPK8 -0.014 0.1 -9999 0 -10000 0 0
MAPK9 -0.005 0.057 -9999 0 -10000 0 0
ERBB2 -0.004 0.043 -9999 0 -0.44 3 3
ERBB3 -0.001 0.091 -9999 0 -0.7 5 5
SHC1 0.012 0.001 -9999 0 -10000 0 0
RAC1 0.013 0 -9999 0 -10000 0 0
apoptosis 0.001 0.009 -9999 0 -10000 0 0
STAT3 (dimer) 0.019 0.005 -9999 0 -10000 0 0
RNF41 0.024 0.007 -9999 0 -10000 0 0
FRAP1 0.009 0.002 -9999 0 -10000 0 0
RAC1-CDC42/GTP -0.027 0.07 -9999 0 -10000 0 0
ErbB2/ErbB2/HSP90 (dimer) -0.004 0.036 -9999 0 -0.36 3 3
CHRNA1 -0.2 0.3 -9999 0 -0.66 66 66
myelination 0.001 0.1 -9999 0 -0.42 3 3
PPP3CB -0.016 0.1 -9999 0 -10000 0 0
KRAS 0.012 0.001 -9999 0 -10000 0 0
RAC1-CDC42/GDP 0.002 0.092 -9999 0 -10000 0 0
NRG2 -0.061 0.21 -9999 0 -0.66 33 33
mol:GDP -0.014 0.1 -9999 0 -0.33 25 25
SOS1 0.012 0.001 -9999 0 -10000 0 0
MAP2K2 -0.031 0.11 -9999 0 -10000 0 0
SRC 0.013 0 -9999 0 -10000 0 0
mol:cAMP -0.001 0.001 -9999 0 -10000 0 0
PTPN11 -0.018 0.11 -9999 0 -10000 0 0
MAP2K1 -0.11 0.19 -9999 0 -0.57 10 10
heart morphogenesis -0.024 0.11 -9999 0 -10000 0 0
RAS family/GDP -0.009 0.091 -9999 0 -10000 0 0
GRB2 0.012 0.001 -9999 0 -10000 0 0
PRKACA -0.003 0.007 -9999 0 -10000 0 0
CHRNE 0.002 0.043 -9999 0 -0.19 12 12
HSP90AA1 0.013 0 -9999 0 -10000 0 0
activation of caspase activity -0.011 0.003 -9999 0 -10000 0 0
nervous system development -0.024 0.11 -9999 0 -10000 0 0
CDC42 0.013 0 -9999 0 -10000 0 0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)

Figure S80.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S80.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MET/RANBP9 0.006 0.085 -10000 0 -0.54 7 7
CRKL 0 0.099 -10000 0 -0.42 4 4
mol:PIP3 -0.017 0.037 0.62 1 -10000 0 1
AKT1 0.003 0.024 0.42 1 -10000 0 1
PTK2B 0.011 0.034 -10000 0 -0.58 1 1
RAPGEF1 0.007 0.095 -10000 0 -0.4 4 4
RANBP10 0.013 0 -10000 0 -10000 0 0
PIK3CA 0.013 0 -10000 0 -10000 0 0
HGF/MET/SHIP2 -0.059 0.15 -10000 0 -0.46 27 27
MAP3K5 -0.004 0.13 -10000 0 -0.52 9 9
HGF/MET/CIN85/CBL/ENDOPHILINS -0.032 0.16 -10000 0 -0.43 32 32
AP1 -0.017 0.12 -10000 0 -0.45 21 21
mol:SU11274 0 0 -10000 0 -10000 0 0
SHC1 0.013 0 -10000 0 -10000 0 0
apoptosis -0.023 0.16 -10000 0 -0.78 13 13
STAT3 (dimer) 0.003 0.099 -10000 0 -10000 0 0
GAB1/CRKL/SHP2/PI3K -0.03 0.076 -10000 0 -10000 0 0
INPP5D -0.005 0.11 -10000 0 -0.67 8 8
CBL/CRK 0.008 0.094 -10000 0 -0.4 4 4
PTPN11 0.013 0 -10000 0 -10000 0 0
GO:0007205 0 0 -10000 0 -10000 0 0
PLCG1 0.013 0 -10000 0 -10000 0 0
PTEN 0.01 0.042 -10000 0 -0.72 1 1
ELK1 -0.006 0.039 -10000 0 -0.25 7 7
mol:SU5416 0 0 -10000 0 -10000 0 0
SHP2/GRB2/SOS1GAB1 -0.027 0.075 -10000 0 -0.36 8 8
PAK1 0.008 0.029 0.39 1 -10000 0 1
HGF/MET/RANBP10 -0.058 0.15 -10000 0 -0.46 27 27
HRAS -0.018 0.16 -10000 0 -0.69 8 8
DOCK1 0.007 0.095 -10000 0 -0.4 4 4
GAB1 -0.007 0.1 -10000 0 -0.37 11 11
CRK 0.001 0.098 -10000 0 -0.42 4 4
mol:PHA665752 0 0 -10000 0 -10000 0 0
mol:GDP -0.063 0.17 -10000 0 -0.6 27 27
JUN 0.011 0.034 -10000 0 -0.58 1 1
EntrezGene:200958 0 0 -10000 0 -10000 0 0
HGF/MET -0.026 0.11 -10000 0 -0.31 31 31
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
cell morphogenesis 0.024 0.11 -10000 0 -10000 0 0
GRB2/SHC -0.008 0.098 -10000 0 -0.5 4 4
FOS -0.033 0.17 -10000 0 -0.68 20 20
GLMN 0 0 -10000 0 -10000 0 0
cell motility -0.006 0.039 -10000 0 -0.25 7 7
HGF/MET/MUC20 -0.059 0.15 -10000 0 -0.44 41 41
cell migration -0.008 0.096 -10000 0 -0.49 4 4
GRB2 0.013 0 -10000 0 -10000 0 0
CBL 0.013 0 -10000 0 -10000 0 0
MET/RANBP10 0.006 0.085 -10000 0 -0.54 7 7
HGF/MET/Paxillin/FAK1/FAK12/RasGAP -0.004 0.1 -10000 0 -10000 0 0
MET/MUC20 -0.004 0.084 -10000 0 -0.55 7 7
RAP1B 0.012 0.093 -10000 0 -10000 0 0
RAP1A 0.014 0.09 -10000 0 -10000 0 0
HGF/MET/RANBP9 -0.058 0.15 -10000 0 -0.46 27 27
RAF1 -0.01 0.15 -10000 0 -0.64 8 8
STAT3 0.003 0.1 -10000 0 -10000 0 0
cell proliferation -0.003 0.14 -10000 0 -0.6 4 4
RPS6KB1 -0.001 0.039 -10000 0 -10000 0 0
MAPK3 -0.01 0.035 -10000 0 -10000 0 0
MAPK1 -0.01 0.035 -10000 0 -10000 0 0
RANBP9 0.013 0 -10000 0 -10000 0 0
MAPK8 0.015 0.11 -10000 0 -0.49 5 5
SRC 0.004 0.097 -10000 0 -10000 0 0
PI3K -0.01 0.1 -10000 0 -0.48 5 5
MET/Glomulin 0 0.076 -10000 0 -0.49 7 7
SOS1 0.013 0 -10000 0 -10000 0 0
MAP2K1 -0.001 0.14 -10000 0 -0.6 7 7
MET -0.004 0.11 -10000 0 -0.72 7 7
MAP4K1 -0.011 0.14 -10000 0 -0.5 12 12
PTK2 0.013 0 -10000 0 -10000 0 0
MAP2K2 -0.001 0.14 -10000 0 -0.6 7 7
BAD 0.009 0.022 0.39 1 -10000 0 1
MAP2K4 0.005 0.12 -10000 0 -0.5 7 7
SHP2/GRB2/SOS1/GAB1 -0.032 0.089 -10000 0 -0.44 7 7
INPPL1 0.011 0.034 -10000 0 -0.58 1 1
PXN 0.013 0 -10000 0 -10000 0 0
SH3KBP1 -0.002 0.1 -10000 0 -0.72 6 6
HGS -0.016 0.1 -10000 0 -0.36 15 15
PLCgamma1/PKC 0.009 0 -10000 0 -10000 0 0
HGF -0.064 0.22 -10000 0 -0.67 34 34
RASA1 0.013 0 -10000 0 -10000 0 0
NCK1 0.013 0 -10000 0 -10000 0 0
PTPRJ -0.007 0.12 -10000 0 -0.72 8 8
NCK/PLCgamma1 -0.008 0.1 -10000 0 -0.52 4 4
PDPK1 -0.006 0.028 0.47 1 -10000 0 1
HGF/MET/SHIP -0.069 0.17 -10000 0 -0.51 29 29
Hedgehog signaling events mediated by Gli proteins

Figure S81.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S81.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.013 0.001 -9999 0 -10000 0 0
HDAC2 0.013 0.001 -9999 0 -10000 0 0
GNB1/GNG2 -0.023 0.14 -9999 0 -0.47 24 24
forebrain development -0.089 0.2 -9999 0 -0.6 20 20
GNAO1 -0.001 0.091 -9999 0 -0.7 5 5
SMO/beta Arrestin2 -0.021 0.14 -9999 0 -0.54 20 20
SMO -0.038 0.18 -9999 0 -0.72 20 20
ARRB2 0.01 0.006 -9999 0 -10000 0 0
GLI3/SPOP 0.05 0.061 -9999 0 -10000 0 0
mol:GTP -0.001 0.003 -9999 0 -10000 0 0
GSK3B 0.013 0 -9999 0 -10000 0 0
GNAI2 0.01 0.005 -9999 0 -10000 0 0
SIN3/HDAC complex 0.012 0.019 -9999 0 -10000 0 0
GNAI1 0.006 0.06 -9999 0 -0.73 2 2
XPO1 0.011 0.007 -9999 0 -10000 0 0
GLI1/Su(fu) -0.11 0.17 -9999 0 -0.65 11 11
SAP30 0.013 0.001 -9999 0 -10000 0 0
mol:GDP -0.038 0.18 -9999 0 -0.72 20 20
MIM/GLI2A -0.012 0.1 -9999 0 -0.73 5 5
IFT88 0.013 0 -9999 0 -10000 0 0
GNAI3 0.01 0.005 -9999 0 -10000 0 0
GLI2 0.012 0.072 -9999 0 -10000 0 0
GLI3 0.046 0.066 -9999 0 -10000 0 0
CSNK1D 0.013 0 -9999 0 -10000 0 0
CSNK1E 0.013 0 -9999 0 -10000 0 0
SAP18 0.013 0.001 -9999 0 -10000 0 0
embryonic digit morphogenesis 0.013 0 -9999 0 -10000 0 0
GNG2 0.001 0.091 -9999 0 -0.7 5 5
Gi family/GTP -0.021 0.12 -9999 0 -0.38 19 19
SIN3B 0.013 0.001 -9999 0 -10000 0 0
SIN3A 0.013 0.001 -9999 0 -10000 0 0
GLI3/Su(fu) 0.039 0.064 -9999 0 -0.64 1 1
GLI2/Su(fu) 0.003 0.1 -9999 0 -0.94 1 1
FOXA2 -0.26 0.45 -9999 0 -1.2 47 47
neural tube patterning -0.089 0.2 -9999 0 -0.6 20 20
SPOP 0.013 0 -9999 0 -10000 0 0
Su(fu)/PIAS1 0.004 0.084 -9999 0 -0.67 2 2
GNB1 0.013 0 -9999 0 -10000 0 0
CSNK1G2 0.013 0 -9999 0 -10000 0 0
CSNK1G3 0.013 0 -9999 0 -10000 0 0
MTSS1 -0.012 0.1 -9999 0 -0.73 5 5
embryonic limb morphogenesis -0.089 0.2 -9999 0 -0.6 20 20
SUFU 0 0.092 -9999 0 -0.73 2 2
LGALS3 0.013 0 -9999 0 -10000 0 0
catabolic process 0.049 0.069 -9999 0 -10000 0 0
GLI3A/CBP -0.039 0.12 -9999 0 -0.37 18 18
KIF3A 0.013 0 -9999 0 -10000 0 0
GLI1 -0.091 0.2 -9999 0 -0.61 20 20
RAB23 0.008 0.054 -9999 0 -0.66 2 2
CSNK1A1 0.013 0 -9999 0 -10000 0 0
IFT172 0.013 0 -9999 0 -10000 0 0
RBBP7 0.013 0.001 -9999 0 -10000 0 0
Su(fu)/Galectin3 0.004 0.084 -9999 0 -0.67 2 2
GNAZ -0.05 0.19 -9999 0 -0.62 29 29
RBBP4 0.013 0.001 -9999 0 -10000 0 0
CSNK1G1 0.013 0 -9999 0 -10000 0 0
PIAS1 0.013 0 -9999 0 -10000 0 0
PRKACA 0.013 0 -9999 0 -10000 0 0
GLI2/SPOP 0.018 0.068 -9999 0 -10000 0 0
STK36 0.009 0.043 -9999 0 -0.73 1 1
Gi family/GNB1/GNG2/GDP -0.014 0.12 -9999 0 -0.54 6 6
PTCH1 -0.08 0.2 -9999 0 -0.75 12 12
MIM/GLI1 -0.15 0.28 -9999 0 -0.62 57 57
CREBBP -0.039 0.12 -9999 0 -0.37 6 6
Su(fu)/SIN3/HDAC complex 0.045 0.024 -9999 0 -10000 0 0
IFN-gamma pathway

Figure S82.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S82.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 -0.046 0.16 -9999 0 -0.51 5 5
positive regulation of NF-kappaB transcription factor activity 0 0.001 -9999 0 -10000 0 0
CRKL 0.011 0.034 -9999 0 -0.58 1 1
STAT1 (dimer)/Cbp/p300 -0.016 0.16 -9999 0 -0.82 2 2
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 -0.017 0.053 -9999 0 -0.5 2 2
antigen processing and presentation of peptide antigen via MHC class I -0.072 0.086 -9999 0 -0.43 2 2
CaM/Ca2+ -0.07 0.13 -9999 0 -0.64 2 2
RAP1A 0.013 0 -9999 0 -10000 0 0
STAT1 (dimer)/SHP2 -0.041 0.16 -9999 0 -0.53 4 4
AKT1 -0.023 0.14 -9999 0 -0.56 2 2
MAP2K1 -0.027 0.15 -9999 0 -0.61 2 2
MAP3K11 -0.037 0.15 -9999 0 -0.65 2 2
IFNGR1 0.006 0.015 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
CaM/Ca2+/CAMKII -0.18 0.23 -9999 0 -0.56 56 56
Rap1/GTP -0.054 0.1 -9999 0 -0.56 1 1
CRKL/C3G 0.017 0.025 -9999 0 -0.42 1 1
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TC-PTP -0.06 0.16 -9999 0 -0.69 2 2
CEBPB -0.008 0.16 -9999 0 -0.71 4 4
STAT3 0.013 0 -9999 0 -10000 0 0
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 -0.055 0.2 -9999 0 -0.94 7 7
STAT1 -0.041 0.16 -9999 0 -0.53 4 4
CALM1 0.013 0 -9999 0 -10000 0 0
IFN-gamma (dimer) -0.14 0.29 -9999 0 -0.67 68 68
PIK3CA 0.013 0 -9999 0 -10000 0 0
STAT1 (dimer)/PIAS1 -0.032 0.15 -9999 0 -0.63 2 2
CEBPB/PTGES2/Cbp/p300 -0.044 0.09 -9999 0 -0.5 4 4
mol:Ca2+ -0.048 0.16 -9999 0 -0.5 5 5
MAPK3 -0.014 0.14 -9999 0 -0.63 1 1
STAT1 (dimer) -0.096 0.12 -9999 0 -0.68 2 2
MAPK1 -0.014 0.14 -9999 0 -0.63 1 1
JAK2 0.001 0.061 -9999 0 -0.59 3 3
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
JAK1 0.004 0.047 -9999 0 -0.78 1 1
CAMK2D 0.013 0 -9999 0 -10000 0 0
DAPK1 -0.002 0.16 -9999 0 -0.66 11 11
SMAD7 -0.008 0.069 -9999 0 -10000 0 0
CBL/CRKL/C3G -0.024 0.14 -9999 0 -0.58 2 2
PI3K -0.069 0.13 -9999 0 -0.62 2 2
IFNG -0.14 0.29 -9999 0 -0.67 68 68
apoptosis -0.009 0.12 -9999 0 -0.45 11 11
CAMK2G 0.013 0 -9999 0 -10000 0 0
STAT3 (dimer) 0.013 0 -9999 0 -10000 0 0
CAMK2A -0.16 0.3 -9999 0 -0.67 79 79
CAMK2B -0.14 0.28 -9999 0 -0.64 72 72
FRAP1 -0.02 0.13 -9999 0 -0.52 2 2
PRKCD -0.022 0.14 -9999 0 -0.57 2 2
RAP1B 0.009 0.048 -9999 0 -0.58 2 2
negative regulation of cell growth -0.072 0.086 -9999 0 -0.43 2 2
PTPN2 0.013 0 -9999 0 -10000 0 0
EP300 0.013 0.001 -9999 0 -10000 0 0
IRF1 -0.002 0.15 -9999 0 -1.1 2 2
STAT1 (dimer)/PIASy -0.034 0.15 -9999 0 -0.63 2 2
SOCS1 -0.014 0.16 -9999 0 -1.3 4 4
mol:GDP -0.061 0.12 -9999 0 -0.55 2 2
CASP1 -0.009 0.072 -9999 0 -0.4 1 1
PTGES2 0.013 0 -9999 0 -10000 0 0
IRF9 0.023 0.07 -9999 0 -0.36 4 4
mol:PI-3-4-5-P3 -0.067 0.13 -9999 0 -0.6 2 2
RAP1/GDP -0.054 0.1 -9999 0 -0.57 1 1
CBL -0.038 0.15 -9999 0 -0.65 2 2
MAP3K1 -0.037 0.15 -9999 0 -0.65 2 2
PIAS1 0.013 0 -9999 0 -10000 0 0
PIAS4 0.012 0.001 -9999 0 -10000 0 0
antigen processing and presentation of peptide antigen via MHC class II -0.072 0.086 -9999 0 -0.43 2 2
PTPN11 -0.047 0.16 -9999 0 -0.5 5 5
CREBBP 0.013 0.001 -9999 0 -10000 0 0
RAPGEF1 0.013 0 -9999 0 -10000 0 0
Paxillin-dependent events mediated by a4b1

Figure S83.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S83.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.011 0.034 -9999 0 -0.58 1 1
Rac1/GDP 0.004 0.015 -9999 0 -10000 0 0
DOCK1 0.013 0 -9999 0 -10000 0 0
ITGA4 -0.034 0.18 -9999 0 -0.69 20 20
RAC1 0.013 0 -9999 0 -10000 0 0
alpha4/beta7 Integrin -0.029 0.16 -9999 0 -0.54 26 26
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.013 0 -9999 0 -10000 0 0
alpha4/beta1 Integrin -0.03 0.11 -9999 0 -0.43 21 21
alpha4/beta7 Integrin/Paxillin -0.006 0.13 -9999 0 -0.44 21 21
lamellipodium assembly 0.002 0.031 -9999 0 -0.44 1 1
PIK3CA 0.013 0 -9999 0 -10000 0 0
PI3K 0.016 0.041 -9999 0 -0.48 2 2
ARF6 0.013 0 -9999 0 -10000 0 0
TLN1 0.011 0.034 -9999 0 -0.58 1 1
PXN 0.022 0 -9999 0 -10000 0 0
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
ARF6/GTP -0.023 0.084 -9999 0 -10000 0 0
cell adhesion 0.009 0.1 -9999 0 -0.39 15 15
CRKL/CBL 0.017 0.025 -9999 0 -0.42 1 1
alpha4/beta1 Integrin/Paxillin 0.003 0.11 -9999 0 -0.42 15 15
ITGB1 0.011 0.034 -9999 0 -0.58 1 1
ITGB7 -0.004 0.11 -9999 0 -0.72 7 7
ARF6/GDP 0.004 0.015 -9999 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin/VCAM1 -0.054 0.2 -9999 0 -0.79 12 12
p130Cas/Crk/Dock1 0 0 -9999 0 -10000 0 0
VCAM1 -0.1 0.25 -9999 0 -0.65 54 54
alpha4/beta1 Integrin/Paxillin/Talin 0.01 0.1 -9999 0 -0.39 15 15
alpha4/beta1 Integrin/Paxillin/GIT1 0.011 0.1 -9999 0 -10000 0 0
BCAR1 0.013 0 -9999 0 -10000 0 0
mol:GDP -0.01 0.1 -9999 0 -10000 0 0
CBL 0.013 0 -9999 0 -10000 0 0
PRKACA 0.013 0 -9999 0 -10000 0 0
GIT1 0.013 0 -9999 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin/Talin/Actin Cytoskeleton 0.01 0.1 -9999 0 -0.39 15 15
Rac1/GTP 0.002 0.034 -9999 0 -0.49 1 1
Regulation of p38-alpha and p38-beta

Figure S84.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S84.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
RIP1/MEKK3 0 0 -9999 0 -10000 0 0
response to insulin stimulus 0 0 -9999 0 -10000 0 0
RIPK1 0.013 0 -9999 0 -10000 0 0
response to stress 0 0 -9999 0 -10000 0 0
MAP2K6 -0.018 0.14 -9999 0 -0.69 13 13
mol:GTP 0 0 -9999 0 -10000 0 0
MAP2K4 0.013 0 -9999 0 -10000 0 0
RAC1-CDC42/GTP/PAK family -0.009 0.08 -9999 0 -10000 0 0
response to UV 0 0 -9999 0 -10000 0 0
YES1 0.013 0 -9999 0 -10000 0 0
interleukin-1 receptor activity 0 0 -9999 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 -9999 0 -10000 0 0
MAP3K3 0.013 0 -9999 0 -10000 0 0
FYN 0.006 0.069 -9999 0 -0.68 3 3
MAP3K12 0.01 0.042 -9999 0 -0.72 1 1
FGR -0.014 0.13 -9999 0 -0.66 12 12
p38 alpha/TAB1 -0.038 0.082 -9999 0 -0.37 11 11
PRKG1 -0.032 0.17 -9999 0 -0.7 19 19
DUSP8 0.011 0.034 -9999 0 -0.58 1 1
PGK/cGMP/p38 alpha -0.055 0.12 -9999 0 -0.43 21 21
apoptosis -0.037 0.079 -9999 0 -0.35 11 11
RAL/GTP 0 0 -9999 0 -10000 0 0
LYN 0.01 0.042 -9999 0 -0.72 1 1
DUSP1 -0.011 0.12 -9999 0 -0.65 11 11
PAK1 0.011 0.034 -9999 0 -0.58 1 1
SRC 0.013 0 -9999 0 -10000 0 0
RAC1/OSM/MEKK3/MKK3 0.031 0.026 -9999 0 -0.42 1 1
TRAF6 0.011 0.034 -9999 0 -0.58 1 1
RAC1 0.013 0 -9999 0 -10000 0 0
epidermal growth factor receptor activity 0 0 -9999 0 -10000 0 0
mol:LPS 0 0 -9999 0 -10000 0 0
mol:cGMP 0 0 -9999 0 -10000 0 0
CCM2 0.013 0 -9999 0 -10000 0 0
RAC1-CDC42/GTP 0 0 -9999 0 -10000 0 0
MAPK11 -0.025 0.14 -9999 0 -0.53 11 11
BLK -0.18 0.3 -9999 0 -0.64 87 87
HCK -0.006 0.12 -9999 0 -0.71 8 8
MAP2K3 0.01 0.042 -9999 0 -0.72 1 1
DUSP16 0.013 0 -9999 0 -10000 0 0
DUSP10 -0.001 0.097 -9999 0 -0.68 6 6
TRAF6/MEKK3 0.015 0.02 -9999 0 -0.33 1 1
MAP3K7IP1 0 0 -9999 0 -10000 0 0
MAPK14 -0.008 0.11 -9999 0 -0.4 11 11
positive regulation of innate immune response -0.021 0.15 -9999 0 -0.56 11 11
LCK -0.032 0.17 -9999 0 -0.67 20 20
p38alpha-beta/MKP7 -0.014 0.14 -9999 0 -0.55 9 9
p38alpha-beta/MKP5 -0.02 0.15 -9999 0 -0.54 11 11
PGK/cGMP -0.024 0.13 -9999 0 -0.53 19 19
PAK2 0.013 0 -9999 0 -10000 0 0
p38alpha-beta/MKP1 -0.025 0.15 -9999 0 -0.54 11 11
CDC42 0.013 0 -9999 0 -10000 0 0
RALB 0.013 0 -9999 0 -10000 0 0
RALA 0.013 0 -9999 0 -10000 0 0
PAK3 -0.094 0.24 -9999 0 -0.63 49 49
IGF1 pathway

Figure S85.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S85.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NCK2 0.013 0 -10000 0 -10000 0 0
PTK2 0.013 0 -10000 0 -10000 0 0
CRKL -0.028 0.12 -10000 0 -0.38 17 17
GRB2/SOS1/SHC 0 0 -10000 0 -10000 0 0
HRAS 0.011 0.034 -10000 0 -0.58 1 1
IRS1/Crk -0.027 0.12 -10000 0 -0.38 17 17
IGF-1R heterotetramer/IGF1/PTP1B -0.052 0.13 -10000 0 -0.44 17 17
AKT1 -0.004 0.11 -10000 0 -0.56 2 2
BAD 0.003 0.11 -10000 0 -0.6 1 1
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.027 0.12 -10000 0 -0.38 17 17
IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.027 0.12 -10000 0 -0.38 17 17
RAF1 0.009 0.1 -10000 0 -0.56 1 1
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos -0.018 0.12 -10000 0 -10000 0 0
YWHAZ 0.013 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 -0.038 0.13 -10000 0 -0.39 25 25
PIK3CA 0.013 0 -10000 0 -10000 0 0
RPS6KB1 -0.004 0.11 -10000 0 -0.56 2 2
GNB2L1 0.013 0 -10000 0 -10000 0 0
positive regulation of MAPKKK cascade 0.007 0.091 -10000 0 -0.47 1 1
PXN 0.013 0 -10000 0 -10000 0 0
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
cell adhesion 0 0 -10000 0 -10000 0 0
GRB2/SOS1 0.019 0 -10000 0 -10000 0 0
HRAS/GTP -0.04 0.091 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc -0.039 0.098 -10000 0 -10000 0 0
IGF-1R heterotetramer 0.001 0.029 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS/Nck -0.026 0.12 -10000 0 -0.38 17 17
Crk/p130 Cas/Paxillin -0.011 0.11 -10000 0 -10000 0 0
IGF1R 0.001 0.029 -10000 0 -10000 0 0
IGF1 -0.079 0.23 -10000 0 -0.64 42 42
IRS2/Crk -0.026 0.13 -10000 0 -0.48 3 3
PI3K -0.02 0.12 -10000 0 -0.64 2 2
apoptosis -0.011 0.096 0.51 1 -10000 0 1
HRAS/GDP 0.008 0.025 -10000 0 -0.43 1 1
PRKCD -0.009 0.12 -10000 0 -0.45 17 17
RAF1/14-3-3 E 0.016 0.092 -10000 0 -0.47 1 1
BAD/14-3-3 0.011 0.1 -10000 0 -0.55 1 1
PRKCZ -0.005 0.12 -10000 0 -0.56 2 2
Crk/p130 Cas/Paxillin/FAK1 -0.033 0.08 -10000 0 -0.55 1 1
PTPN1 0.013 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 -0.017 0.13 -10000 0 -0.48 17 17
BCAR1 0.013 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/SHC/GRB10 -0.052 0.12 -10000 0 -0.41 21 21
mol:GDP 0 0 -10000 0 -10000 0 0
SOS1 0.013 0 -10000 0 -10000 0 0
IRS1/NCK2 -0.027 0.12 -10000 0 -0.38 17 17
GRB10 -0.001 0.1 -10000 0 -0.7 6 6
PTPN11 -0.027 0.12 -10000 0 -0.38 17 17
IRS1 -0.038 0.13 -10000 0 -0.39 25 25
IRS2 -0.035 0.13 -10000 0 -0.4 20 20
IGF-1R heterotetramer/IGF1 -0.053 0.17 -10000 0 -0.47 42 42
GRB2 0.013 0 -10000 0 -10000 0 0
PDPK1 -0.012 0.12 -10000 0 -0.6 2 2
YWHAE 0.013 0 -10000 0 -10000 0 0
PRKD1 -0.04 0.17 -10000 0 -0.54 19 19
SHC1 0.013 0 -10000 0 -10000 0 0
PDGFR-beta signaling pathway

Figure S86.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S86.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
S1P1/Sphingosine-1-phosphate -0.015 0.099 -9999 0 -0.56 9 9
PDGFB-D/PDGFRB/SLAP -0.025 0.16 -9999 0 -0.57 23 23
PDGFB-D/PDGFRB/APS/CBL -0.015 0.1 -9999 0 -0.45 16 16
AKT1 0.039 0.085 -9999 0 -0.56 2 2
mol:PI-4-5-P2 0 0.001 -9999 0 -10000 0 0
mol:Sphingosine-1-phosphate 0.009 0.11 -9999 0 -0.6 9 9
PIK3CA 0.013 0 -9999 0 -10000 0 0
FGR -0.024 0.11 -9999 0 -0.51 14 14
mol:Ca2+ 0.002 0.12 -9999 0 -0.64 9 9
MYC 0.025 0.085 -9999 0 -0.49 2 2
SHC1 0.013 0 -9999 0 -10000 0 0
HRAS/GDP 0.022 0.074 -9999 0 -0.38 2 2
LRP1/PDGFRB/PDGFB -0.008 0.094 -9999 0 -0.48 11 11
GRB10 -0.001 0.1 -9999 0 -0.7 6 6
PTPN11 0.013 0 -9999 0 -10000 0 0
GO:0007205 0.002 0.12 -9999 0 -0.65 9 9
PTEN 0.01 0.042 -9999 0 -0.72 1 1
GRB2 0.013 0 -9999 0 -10000 0 0
GRB7 -0.002 0.099 -9999 0 -0.64 7 7
PDGFB-D/PDGFRB/SHP2 0.001 0.098 -9999 0 -0.53 10 10
PDGFB-D/PDGFRB/GRB10 -0.009 0.12 -9999 0 -0.53 16 16
cell cycle arrest -0.025 0.16 -9999 0 -0.57 23 23
HRAS 0.011 0.034 -9999 0 -0.58 1 1
HIF1A 0.044 0.077 -9999 0 -0.49 2 2
GAB1 -0.002 0.12 -9999 0 -0.62 9 9
mol:GTP 0 0 -9999 0 -10000 0 0
DNM2 0.005 0.11 -9999 0 -0.56 9 9
PDGFB-D/PDGFRB -0.004 0.086 -9999 0 -0.47 9 9
mol:GDP 0 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/LMW-PTP 0.001 0.098 -9999 0 -0.53 10 10
S1P1/Sphingosine-1-phosphate/PDGFB-D/PDGFRB -0.016 0.096 -9999 0 -0.53 9 9
positive regulation of MAPKKK cascade 0.001 0.098 -9999 0 -0.53 10 10
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
mol:IP3 0.002 0.12 -9999 0 -0.66 9 9
E5 0 0.001 -9999 0 -10000 0 0
CSK 0.012 0.001 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/GRB7 -0.01 0.13 -9999 0 -0.54 16 16
SHB 0.008 0.06 -9999 0 -0.72 2 2
BLK -0.11 0.21 -9999 0 -0.6 41 41
PTPN2 0.013 0.002 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/SNX15 0.001 0.098 -9999 0 -0.53 10 10
BCAR1 0.013 0 -9999 0 -10000 0 0
VAV2 0.001 0.12 -9999 0 -0.6 9 9
CBL 0.013 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB/DEP1 -0.013 0.14 -9999 0 -0.59 16 16
LCK -0.037 0.14 -9999 0 -0.54 20 20
PDGFRB -0.01 0.13 -9999 0 -0.72 10 10
ACP1 0.013 0 -9999 0 -10000 0 0
HCK -0.02 0.13 -9999 0 -0.54 15 15
ABL1 -0.005 0.11 -9999 0 -0.57 9 9
PDGFB-D/PDGFRB/CBL -0.007 0.13 -9999 0 -0.68 9 9
PTPN1 0.013 0.002 -9999 0 -10000 0 0
SNX15 0.013 0 -9999 0 -10000 0 0
STAT3 0.013 0 -9999 0 -10000 0 0
STAT1 0.003 0.08 -9999 0 -0.69 4 4
cell proliferation 0.025 0.08 -9999 0 -0.45 2 2
SLA -0.023 0.16 -9999 0 -0.72 15 15
actin cytoskeleton reorganization 0.034 0.077 -9999 0 -10000 0 0
SRC -0.008 0.079 -9999 0 -0.46 8 8
PI3K -0.018 0.082 -9999 0 -0.64 2 2
PDGFB-D/PDGFRB/GRB7/SHC -0.015 0.11 -9999 0 -0.49 12 12
SH2B2 -0.001 0.1 -9999 0 -0.7 6 6
PLCgamma1/SPHK1 0.009 0.12 -9999 0 -0.62 9 9
LYN -0.009 0.087 -9999 0 -0.47 9 9
LRP1 0.01 0.042 -9999 0 -0.72 1 1
SOS1 0.013 0 -9999 0 -10000 0 0
STAT5B 0.013 0 -9999 0 -10000 0 0
STAT5A 0.013 0 -9999 0 -10000 0 0
NCK1-2/p130 Cas -0.003 0.068 -9999 0 -10000 0 0
SPHK1 0.013 0.002 -9999 0 -10000 0 0
EDG1 0 0.002 -9999 0 -10000 0 0
mol:DAG 0.002 0.12 -9999 0 -0.66 9 9
PLCG1 0.001 0.12 -9999 0 -0.68 9 9
NHERF/PDGFRB -0.011 0.11 -9999 0 -0.52 12 12
YES1 -0.007 0.08 -9999 0 -0.46 8 8
cell migration -0.015 0.11 -9999 0 -0.51 12 12
SHC/Grb2/SOS1 -0.003 0.068 -9999 0 -10000 0 0
SLC9A3R2 0.008 0.054 -9999 0 -0.66 2 2
SLC9A3R1 0.008 0.06 -9999 0 -0.72 2 2
NHERF1-2/PDGFRB/PTEN 0.012 0.1 -9999 0 -0.48 12 12
FYN -0.013 0.12 -9999 0 -0.62 9 9
DOK1 0.013 0.097 -9999 0 -0.46 11 11
HRAS/GTP 0.008 0.025 -9999 0 -0.43 1 1
PDGFB 0.011 0.034 -9999 0 -0.58 1 1
RAC1 0.015 0.11 -9999 0 -0.54 9 9
PRKCD 0.018 0.08 -9999 0 -0.42 9 9
FER 0.018 0.08 -9999 0 -0.42 9 9
MAPKKK cascade -0.011 0.063 -9999 0 -10000 0 0
RASA1 0.018 0.08 -9999 0 -0.42 9 9
NCK1 0.013 0 -9999 0 -10000 0 0
NCK2 0.013 0 -9999 0 -10000 0 0
p62DOK/Csk 0.02 0.09 -9999 0 -0.78 1 1
PDGFB-D/PDGFRB/SHB -0.002 0.11 -9999 0 -0.53 12 12
chemotaxis -0.004 0.11 -9999 0 -0.55 9 9
STAT1-3-5/STAT1-3-5 -0.016 0.078 -9999 0 -0.74 1 1
Bovine Papilomavirus E5/PDGFRB -0.008 0.099 -9999 0 -0.54 10 10
PTPRJ -0.007 0.12 -9999 0 -0.72 8 8
Signaling events mediated by PRL

Figure S87.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S87.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCNE1 0.011 0.034 -10000 0 -0.58 1 1
mol:Halofuginone 0.005 0 -10000 0 -10000 0 0
ITGA1 -0.011 0.13 -10000 0 -0.7 10 10
CDKN1A 0.028 0.034 -10000 0 -0.43 1 1
PRL-3/alpha Tubulin 0.009 0.068 -10000 0 -0.46 6 6
mol:Ca2+ -0.1 0.2 -10000 0 -0.48 66 66
AGT -0.13 0.28 -10000 0 -0.65 66 66
CCNA2 0.033 0.054 -10000 0 -10000 0 0
TUBA1B 0.013 0 -10000 0 -10000 0 0
EGR1 0.015 0.066 -10000 0 -0.49 5 5
CDK2/Cyclin E1 0.038 0.035 -10000 0 -10000 0 0
MAPK3 0.012 0.068 -10000 0 -0.46 6 6
PRL-2 /Rab GGTase beta 0.019 0 -10000 0 -10000 0 0
MAPK1 0.012 0.068 -10000 0 -0.46 6 6
PTP4A1 0.029 0.052 -10000 0 -10000 0 0
PTP4A3 0 0.09 -10000 0 -0.63 6 6
PTP4A2 0.013 0 -10000 0 -10000 0 0
ITGB1 0.011 0.073 -10000 0 -0.46 7 7
SRC 0.013 0 -10000 0 -10000 0 0
RAC1 0.024 0.048 -10000 0 -0.42 2 2
Rab GGTase beta/Rab GGTase alpha 0.019 0 -10000 0 -10000 0 0
PRL-1/ATF-5 0.025 0.071 -10000 0 -10000 0 0
RABGGTA 0.013 0 -10000 0 -10000 0 0
BCAR1 0.007 0.048 0.34 6 -10000 0 6
RHOC 0.024 0.048 -10000 0 -0.42 2 2
RHOA 0.024 0.048 -10000 0 -0.42 2 2
cell motility 0.029 0.049 -10000 0 -0.42 2 2
PRL-1/alpha Tubulin 0.033 0.049 -10000 0 -10000 0 0
PRL-3/alpha1 Integrin -0.008 0.12 -10000 0 -0.5 16 16
ROCK1 0.029 0.049 -10000 0 -0.43 2 2
RABGGTB 0.013 0 -10000 0 -10000 0 0
CDK2 0.013 0 -10000 0 -10000 0 0
mitosis 0.029 0.052 -10000 0 -10000 0 0
ATF5 -0.003 0.096 -10000 0 -0.58 8 8
Lissencephaly gene (LIS1) in neuronal migration and development

Figure S88.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S88.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
DYNC1H1 0.013 0 -9999 0 -10000 0 0
VLDLR -0.006 0.11 -9999 0 -0.69 8 8
LRPAP1 0.013 0 -9999 0 -10000 0 0
NUDC 0.013 0 -9999 0 -10000 0 0
RELN/LRP8 -0.085 0.17 -9999 0 -0.48 30 30
CaM/Ca2+ 0.009 0 -9999 0 -10000 0 0
KATNA1 0.013 0 -9999 0 -10000 0 0
GO:0030286 0 0 -9999 0 -10000 0 0
ABL1 -0.05 0.17 -9999 0 -0.43 30 30
IQGAP1/CaM 0.019 0 -9999 0 -10000 0 0
DAB1 -0.02 0.13 -9999 0 -0.58 15 15
IQGAP1 0.013 0 -9999 0 -10000 0 0
PLA2G7 -0.018 0.14 -9999 0 -0.69 13 13
CALM1 0.013 0 -9999 0 -10000 0 0
DYNLT1 0.013 0 -9999 0 -10000 0 0
mol:Ca2+ 0 0 -9999 0 -10000 0 0
LRPAP1/LRP8 0.011 0.064 -9999 0 -0.54 4 4
UniProt:Q4QZ09 0 0 -9999 0 -10000 0 0
CLIP1 0.013 0 -9999 0 -10000 0 0
CDK5R1 0.001 0.091 -9999 0 -0.7 5 5
LIS1/Poliovirus Protein 3A 0.016 0 -9999 0 -10000 0 0
CDK5R2 -0.044 0.17 -9999 0 -0.59 27 27
mol:PP1 0 0 -9999 0 -10000 0 0
RELN/VLDLR/DAB1 -0.11 0.19 -9999 0 -0.51 36 36
YWHAE 0.013 0 -9999 0 -10000 0 0
NDEL1/14-3-3 E -0.033 0.15 -9999 0 -0.55 4 4
MAP1B -0.015 0.064 -9999 0 -0.36 7 7
RAC1 0 0 -9999 0 -10000 0 0
p35/CDK5 -0.036 0.16 -9999 0 -0.74 2 2
RELN -0.12 0.26 -9999 0 -0.65 59 59
PAFAH/LIS1 0.006 0.095 -9999 0 -0.46 10 10
LIS1/CLIP170 0.026 0 -9999 0 -10000 0 0
LIS1/NDEL1/Katanin 60/Dynein Light chain/Dynein heavy chain -0.055 0.097 -9999 0 -0.49 1 1
RELN/VLDLR/DAB1/LIS1/PAFAH1B2/PAFAH1B3 -0.031 0.12 -9999 0 -0.54 2 2
GO:0005869 0 0 -9999 0 -10000 0 0
NDEL1 -0.043 0.16 -9999 0 -0.6 4 4
LIS1/IQGAP1 0.026 0 -9999 0 -10000 0 0
RHOA 0 0 -9999 0 -10000 0 0
PAFAH1B1 0.022 0 -9999 0 -10000 0 0
PAFAH1B3 0.013 0 -9999 0 -10000 0 0
PAFAH1B2 0.01 0.042 -9999 0 -0.72 1 1
MAP1B/LIS1/Dynein heavy chain 0.014 0.045 -9999 0 -10000 0 0
NDEL1/Katanin 60/Dynein heavy chain -0.06 0.13 -9999 0 -0.58 2 2
LRP8 0.003 0.084 -9999 0 -0.72 4 4
NDEL1/Katanin 60 -0.033 0.15 -9999 0 -0.55 4 4
P39/CDK5 -0.06 0.17 -9999 0 -0.61 7 7
LIS1/NudC/Dynein intermediate chain/microtubule organizing center 0.026 0 -9999 0 -10000 0 0
CDK5 -0.039 0.16 -9999 0 -0.77 1 1
PPP2R5D 0.013 0 -9999 0 -10000 0 0
LIS1/CLIP170/Dynein Complex/Dynactin Complex 0 0 -9999 0 -10000 0 0
CSNK2A1 0.013 0 -9999 0 -10000 0 0
RELN/VLDLR/DAB1/LIS1 -0.063 0.18 -9999 0 -0.64 6 6
RELN/VLDLR -0.061 0.18 -9999 0 -0.45 36 36
CDC42 0 0 -9999 0 -10000 0 0
Nectin adhesion pathway

Figure S89.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S89.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB -0.011 0.13 -9999 0 -0.71 10 10
alphaV beta3 Integrin -0.021 0.15 -9999 0 -0.56 21 21
PTK2 -0.035 0.12 -9999 0 -0.94 3 3
positive regulation of JNK cascade -0.015 0.062 -9999 0 -0.36 8 8
CDC42/GDP 0.031 0.096 -9999 0 -0.49 8 8
Rac1/GDP 0.033 0.095 -9999 0 -0.49 8 8
RAP1B 0.009 0.048 -9999 0 -0.58 2 2
RAP1A 0.013 0 -9999 0 -10000 0 0
CTNNB1 0.008 0.06 -9999 0 -0.72 2 2
CDC42/GTP -0.018 0.077 -9999 0 -0.46 8 8
nectin-3/I-afadin -0.011 0.12 -9999 0 -0.48 18 18
RAPGEF1 0.026 0.1 -9999 0 -0.54 8 8
mol:GTP 0 0 -9999 0 -10000 0 0
CRK 0.018 0.12 -9999 0 -0.64 8 8
PDGFB-D/PDGFRB -0.011 0.13 -9999 0 -0.71 10 10
TLN1 0.013 0.079 -9999 0 -0.55 3 3
Rap1/GTP -0.016 0.064 -9999 0 -0.44 3 3
IQGAP1 0.013 0 -9999 0 -10000 0 0
Rap1/GTP/I-afadin 0.022 0.028 -9999 0 -10000 0 0
nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin -0.011 0.12 -9999 0 -0.48 18 18
PVR 0.011 0.034 -9999 0 -0.58 1 1
Necl-5(dimer) 0.011 0.034 -9999 0 -0.58 1 1
mol:GDP 0.027 0.12 -9999 0 -0.62 8 8
MLLT4 0.013 0 -9999 0 -10000 0 0
PIK3CA 0.013 0 -9999 0 -10000 0 0
PI3K -0.035 0.12 -9999 0 -0.79 2 2
nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin 0.017 0.032 -9999 0 -0.54 1 1
positive regulation of lamellipodium assembly -0.017 0.065 -9999 0 -0.37 8 8
PVRL1 0.01 0.042 -9999 0 -0.72 1 1
PVRL3 -0.027 0.16 -9999 0 -0.65 18 18
PVRL2 0.013 0 -9999 0 -10000 0 0
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
CDH1 0.005 0.073 -9999 0 -0.72 3 3
CLDN1 -0.042 0.19 -9999 0 -0.71 23 23
JAM-A/CLDN1 -0.025 0.16 -9999 0 -0.46 27 27
SRC -0.03 0.12 -9999 0 -0.73 8 8
ITGB3 -0.034 0.18 -9999 0 -0.7 20 20
nectin-1(dimer)/I-afadin/I-afadin 0.017 0.032 -9999 0 -0.54 1 1
FARP2 0.022 0.12 -9999 0 -0.64 8 8
RAC1 0.013 0 -9999 0 -10000 0 0
CTNNA1 0.013 0 -9999 0 -10000 0 0
nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) -0.025 0.098 -9999 0 -0.46 8 8
nectin-1/I-afadin 0.017 0.032 -9999 0 -0.54 1 1
nectin-2/I-afadin 0.019 0 -9999 0 -10000 0 0
RAC1/GTP/IQGAP1/filamentous actin 0 0 -9999 0 -10000 0 0
nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin -0.025 0.1 -9999 0 -0.46 9 9
CDC42/GTP/IQGAP1/filamentous actin 0 0 -9999 0 -10000 0 0
F11R 0.01 0.042 -9999 0 -0.72 1 1
positive regulation of filopodium formation -0.015 0.062 -9999 0 -0.36 8 8
alphaV/beta3 Integrin/Talin -0.002 0.15 -9999 0 -0.8 6 6
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.019 0 -9999 0 -10000 0 0
nectin-2(dimer)/I-afadin/I-afadin 0.019 0 -9999 0 -10000 0 0
PIP5K1C 0.007 0.082 -9999 0 -0.59 3 3
VAV2 0.019 0.12 -9999 0 -0.58 10 10
RAP1/GDP -0.019 0.077 -9999 0 -0.52 4 4
ITGAV 0.005 0.073 -9999 0 -0.72 3 3
nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin -0.024 0.096 -9999 0 -0.46 8 8
nectin-3(dimer)/I-afadin/I-afadin -0.011 0.12 -9999 0 -0.48 18 18
Rac1/GTP -0.021 0.08 -9999 0 -0.46 8 8
PTPRM -0.001 0.088 -9999 0 -0.37 11 11
E-cadherin/beta catenin/alpha catenin -0.007 0.06 -9999 0 -0.76 1 1
adherens junction assembly 0 0 -9999 0 -10000 0 0
CDC42 0.013 0 -9999 0 -10000 0 0
Ceramide signaling pathway

Figure S90.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S90.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.016 0.056 -10000 0 -0.54 3 3
MAP4K4 0.006 0.11 -10000 0 -0.55 5 5
BAG4 0.011 0.034 -10000 0 -0.58 1 1
PKC zeta/ceramide -0.018 0.05 -10000 0 -0.42 1 1
NFKBIA 0.013 0 -10000 0 -10000 0 0
BIRC3 -0.038 0.17 -10000 0 -0.61 25 25
BAX -0.005 0.022 -10000 0 -10000 0 0
RIPK1 0.013 0 -10000 0 -10000 0 0
AKT1 0.02 0.011 -10000 0 -10000 0 0
BAD -0.017 0.044 -10000 0 -10000 0 0
SMPD1 0 0.075 -10000 0 -0.29 6 6
RB1 -0.02 0.057 -10000 0 -0.46 2 2
FADD/Caspase 8 -0.011 0.14 -10000 0 -0.55 7 7
MAP2K4 -0.01 0.042 -10000 0 -10000 0 0
NSMAF 0.013 0 -10000 0 -10000 0 0
response to UV 0 0 -10000 0 -10000 0 0
RAF1 -0.011 0.045 -10000 0 -0.3 1 1
EGF -0.14 0.29 -10000 0 -0.66 70 70
mol:ceramide -0.027 0.047 0.2 2 -10000 0 2
MADD 0.013 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
mol:Free Fatty acid 0.016 0.056 -10000 0 -0.54 3 3
ASAH1 0.013 0 -10000 0 -10000 0 0
negative regulation of cell cycle -0.02 0.056 0.19 1 -0.45 2 3
cell proliferation -0.035 0.11 -10000 0 -0.39 3 3
BID 0 0.092 -10000 0 -0.54 4 4
MAP3K1 -0.017 0.044 0.19 2 -10000 0 2
EIF2A -0.004 0.048 -10000 0 -0.46 1 1
TRADD 0.013 0 -10000 0 -10000 0 0
CRADD 0.013 0 -10000 0 -10000 0 0
MAPK3 0.001 0.042 -10000 0 -10000 0 0
response to heat 0 0 -10000 0 -10000 0 0
MAPK1 0.001 0.042 -10000 0 -10000 0 0
Cathepsin D/ceramide -0.017 0.044 -10000 0 -10000 0 0
FADD -0.023 0.14 -10000 0 -0.52 11 11
KSR1 -0.019 0.047 0.19 2 -0.32 1 3
MAPK8 -0.007 0.048 -10000 0 -0.26 3 3
PRKRA -0.017 0.044 0.19 2 -10000 0 2
PDGFA 0.005 0.073 -10000 0 -0.72 3 3
TRAF2 0.009 0.048 -10000 0 -0.58 2 2
IGF1 -0.078 0.23 -10000 0 -0.64 42 42
mol:GD3 0 0 -10000 0 -10000 0 0
ganglioside biosynthetic process -0.027 0.047 0.2 2 -10000 0 2
CTSD 0.013 0 -10000 0 -10000 0 0
regulation of nitric oxide biosynthetic process 0.019 0 -10000 0 -10000 0 0
response to radiation 0 0 -10000 0 -10000 0 0
ERK1/PKC delta -0.032 0.12 -10000 0 -0.42 3 3
PRKCD 0.013 0 -10000 0 -10000 0 0
PRKCZ 0.01 0.042 -10000 0 -0.72 1 1
mol:GW4869 0 0 -10000 0 -10000 0 0
mol:sphingosine 0.016 0.056 -10000 0 -0.54 3 3
RelA/NF kappa B1 0.019 0 -10000 0 -10000 0 0
mol:glutathione 0 0 -10000 0 -10000 0 0
PAWR 0.013 0 -10000 0 -10000 0 0
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD -0.002 0.11 -10000 0 -0.59 5 5
TNFR1A/BAG4/TNF-alpha -0.047 0.13 -10000 0 -0.46 19 19
mol:Sphingosine-1-phosphate 0.016 0.056 -10000 0 -0.54 3 3
MAP2K1 -0.003 0.043 -10000 0 -10000 0 0
mol:C11AG 0 0 -10000 0 -10000 0 0
RELA 0.013 0 -10000 0 -10000 0 0
CYCS 0 0.044 0.18 7 -10000 0 7
TNFRSF1A 0.013 0 -10000 0 -10000 0 0
NFKB1 0.013 0 -10000 0 -10000 0 0
TNFR1A/BAG4 0.017 0.025 -10000 0 -0.42 1 1
EIF2AK2 -0.011 0.05 -10000 0 -0.49 1 1
TNF-alpha/TNFR1A/FAN -0.045 0.13 -10000 0 -0.46 19 19
response to hydrogen peroxide 0 0 -10000 0 -10000 0 0
CASP8 0.019 0.062 -10000 0 -10000 0 0
MAP2K2 -0.003 0.043 -10000 0 -10000 0 0
SMPD3 -0.031 0.12 -10000 0 -0.4 17 17
TNF -0.061 0.21 -10000 0 -0.66 33 33
PKC zeta/PAR4 0.017 0.032 -10000 0 -0.54 1 1
mol:PHOSPHOCHOLINE 0.035 0.11 0.23 64 -10000 0 64
NF kappa B1/RelA/I kappa B alpha -0.001 0.022 -10000 0 -10000 0 0
AIFM1 0 0.044 0.18 7 -10000 0 7
BCL2 -0.037 0.17 -10000 0 -0.62 24 24
Class I PI3K signaling events

Figure S91.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S91.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ARF5/GTP 0 0.021 0.28 1 -10000 0 1
DAPP1 -0.042 0.17 -10000 0 -0.6 16 16
Src family/SYK family/BLNK-LAT/BTK-ITK -0.083 0.24 -10000 0 -0.7 31 31
mol:DAG -0.015 0.11 -10000 0 -0.3 19 19
HRAS 0.012 0.034 -10000 0 -0.58 1 1
RAP1A 0.013 0.001 -10000 0 -10000 0 0
ARF5/GDP 0.025 0.067 -10000 0 -0.32 4 4
PLCG2 0.013 0 -10000 0 -10000 0 0
PLCG1 0.013 0 -10000 0 -10000 0 0
ARF5 0.013 0 -10000 0 -10000 0 0
mol:GTP 0 0.021 0.26 1 -10000 0 1
ARF1/GTP 0 0.02 0.27 1 -10000 0 1
RHOA 0.013 0 -10000 0 -10000 0 0
YES1 0.013 0 -10000 0 -10000 0 0
RAP1A/GTP 0 0.02 -10000 0 -10000 0 0
ADAP1 -0.014 0.07 0.25 1 -10000 0 1
ARAP3 0 0.02 0.25 1 -10000 0 1
INPPL1 0.011 0.034 -10000 0 -0.58 1 1
PREX1 0.001 0.094 -10000 0 -0.72 5 5
ARHGEF6 -0.006 0.12 -10000 0 -0.71 8 8
ARHGEF7 0.011 0.034 -10000 0 -0.58 1 1
ARF1 0.013 0 -10000 0 -10000 0 0
NRAS 0.014 0.001 -10000 0 -10000 0 0
FYN 0.006 0.069 -10000 0 -0.68 3 3
ARF6 0.013 0 -10000 0 -10000 0 0
FGR -0.014 0.13 -10000 0 -0.66 12 12
mol:Ca2+ 0.002 0.06 -10000 0 -10000 0 0
mol:IP4 0 0 -10000 0 -10000 0 0
TIAM1 0.005 0.073 -10000 0 -0.72 3 3
ZAP70 -0.072 0.23 -10000 0 -0.67 38 38
mol:IP3 -0.002 0.082 -10000 0 -10000 0 0
LYN 0.01 0.042 -10000 0 -0.72 1 1
ARF1/GDP 0.025 0.067 -10000 0 -0.32 4 4
RhoA/GDP -0.006 0.032 0.26 1 -10000 0 1
PDK1/Src/Hsp90 0 0 -10000 0 -10000 0 0
BLNK -0.034 0.18 -10000 0 -0.72 19 19
actin cytoskeleton reorganization 0.044 0.074 -10000 0 -0.52 2 2
SRC 0.013 0 -10000 0 -10000 0 0
PLEKHA2 0.014 0.081 -10000 0 -0.46 6 6
RAC1 0.013 0 -10000 0 -10000 0 0
PTEN -0.002 0.04 -10000 0 -0.7 1 1
HSP90AA1 0.013 0 -10000 0 -10000 0 0
ARF6/GTP 0 0.021 0.28 1 -10000 0 1
RhoA/GTP 0 0.02 -10000 0 -10000 0 0
Src family/SYK family/BLNK-LAT -0.089 0.24 -10000 0 -0.67 33 33
BLK -0.18 0.3 -10000 0 -0.64 87 87
PDPK1 0.013 0 -10000 0 -10000 0 0
CYTH1 0 0.02 0.25 1 -10000 0 1
HCK -0.006 0.12 -10000 0 -0.71 8 8
CYTH3 0 0.02 -10000 0 -10000 0 0
CYTH2 0 0.02 -10000 0 -10000 0 0
KRAS 0.014 0.001 -10000 0 -10000 0 0
GO:0030676 0 0 -10000 0 -10000 0 0
FOXO3 0.039 0.043 -10000 0 -0.52 1 1
SGK1 -0.002 0.037 -10000 0 -0.57 1 1
INPP5D -0.005 0.11 -10000 0 -0.67 8 8
mol:GDP 0.018 0.07 -10000 0 -0.35 4 4
SOS1 0.013 0 -10000 0 -10000 0 0
SYK 0.01 0.042 -10000 0 -0.72 1 1
ARF6/GDP -0.006 0.032 0.28 1 -10000 0 1
mol:PI-3-4-5-P3 0 0.024 0.34 1 -10000 0 1
ARAP3/RAP1A/GTP 0 0.02 -10000 0 -10000 0 0
VAV1 -0.021 0.16 -10000 0 -0.72 14 14
mol:PI-3-4-P2 0.007 0.088 -10000 0 -0.49 9 9
RAS family/GTP/PI3K Class I 0.029 0.017 -10000 0 -10000 0 0
PLEKHA1 0.015 0.076 -10000 0 -0.46 5 5
Rac1/GDP 0.025 0.067 -10000 0 -0.35 2 2
LAT -0.013 0.13 -10000 0 -0.64 12 12
Rac1/GTP 0.011 0.12 -10000 0 -0.76 4 4
ITK -0.041 0.11 -10000 0 -10000 0 0
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma -0.029 0.16 -10000 0 -0.42 25 25
LCK -0.032 0.17 -10000 0 -0.67 20 20
BTK -0.017 0.078 0.25 1 -10000 0 1
S1P3 pathway

Figure S92.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S92.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB -0.011 0.13 -9999 0 -0.71 10 10
mol:S1P 0.001 0.003 -9999 0 -10000 0 0
S1P1/S1P/Gi 0.003 0.089 -9999 0 -0.32 12 12
GNAO1 0.002 0.092 -9999 0 -0.7 5 5
S1P/S1P3/G12/G13 0.006 0.094 -9999 0 -0.43 13 13
AKT1 -0.002 0.14 -9999 0 -0.72 9 9
AKT3 0.011 0.17 -9999 0 -1.1 5 5
mol:GTP 0 0 -9999 0 -10000 0 0
PDGFB-D/PDGFRB -0.011 0.13 -9999 0 -0.71 10 10
GNAI2 0.014 0.003 -9999 0 -10000 0 0
GNAI3 0.014 0.003 -9999 0 -10000 0 0
GNAI1 0.009 0.06 -9999 0 -0.72 2 2
mol:GDP 0 0 -9999 0 -10000 0 0
S1PR3 -0.02 0.15 -9999 0 -0.71 14 14
S1PR2 0.013 0 -9999 0 -10000 0 0
EDG1 0 0 -9999 0 -10000 0 0
mol:Ca2+ -0.001 0.13 -9999 0 -0.6 7 7
MAPK3 0.007 0.12 -9999 0 -0.57 7 7
MAPK1 0.007 0.12 -9999 0 -0.57 7 7
JAK2 -0.003 0.14 -9999 0 -0.58 10 10
CXCR4 -0.019 0.17 -9999 0 -0.54 19 19
FLT1 0.01 0.06 -9999 0 -0.72 2 2
RhoA/GDP 0.009 0 -9999 0 -10000 0 0
Rac1/GDP 0.009 0 -9999 0 -10000 0 0
SRC 0.007 0.12 -9999 0 -0.57 7 7
S1P/S1P3/Gi -0.001 0.13 -9999 0 -0.61 7 7
RAC1 0.013 0 -9999 0 -10000 0 0
RhoA/GTP 0.005 0.12 -9999 0 -0.55 7 7
VEGFA 0.013 0.034 -9999 0 -0.58 1 1
S1P/S1P2/Gi 0.013 0.082 -9999 0 -0.4 3 3
VEGFR1 homodimer/VEGFA homodimer 0.021 0.053 -9999 0 -0.5 3 3
RHOA 0.013 0 -9999 0 -10000 0 0
S1P/S1P3/Gq -0.002 0.11 -9999 0 -0.62 4 4
GNAQ 0.013 0 -9999 0 -10000 0 0
GNAZ -0.047 0.19 -9999 0 -0.62 29 29
G12/G13 0.019 0 -9999 0 -10000 0 0
GNA14 -0.024 0.16 -9999 0 -0.68 16 16
GNA15 0.013 0 -9999 0 -10000 0 0
GNA12 0.013 0 -9999 0 -10000 0 0
GNA13 0.013 0 -9999 0 -10000 0 0
GNA11 0.008 0.06 -9999 0 -0.72 2 2
Rac1/GTP 0.005 0.12 -9999 0 -0.55 7 7
p38 MAPK signaling pathway

Figure S93.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S93.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TRAF6/ASK1 0.011 0.027 -9999 0 -0.41 1 1
TRAF2/ASK1 -0.004 0.04 -9999 0 -0.4 3 3
ATM 0.013 0 -9999 0 -10000 0 0
MAP2K3 0.013 0.045 -9999 0 -10000 0 0
response to stress 0 0 -9999 0 -10000 0 0
MAP2K6 0.012 0.069 -9999 0 -0.36 2 2
hyperosmotic response 0 0 -9999 0 -10000 0 0
response to oxidative stress 0 0 -9999 0 -10000 0 0
GADD45G -0.015 0.14 -9999 0 -0.68 12 12
TXN 0.007 0.016 -9999 0 -0.26 1 1
CALM1 0.013 0 -9999 0 -10000 0 0
GADD45A 0.011 0.034 -9999 0 -0.58 1 1
GADD45B 0.011 0.034 -9999 0 -0.58 1 1
MAP3K1 0.013 0 -9999 0 -10000 0 0
MAP3K6 0.008 0.06 -9999 0 -0.72 2 2
MAP3K7 0.013 0 -9999 0 -10000 0 0
MAP3K4 0.013 0 -9999 0 -10000 0 0
mol:Ca2+ 0 0 -9999 0 -10000 0 0
ASK1/ASK2 0.013 0.056 -9999 0 -0.54 3 3
TAK1/TAB family 0 0.007 -9999 0 -10000 0 0
RAC1/OSM/MEKK3 0.025 0 -9999 0 -10000 0 0
TRAF2 0.009 0.048 -9999 0 -0.58 2 2
RAC1/OSM/MEKK3/MKK3 -0.008 0.017 -9999 0 -10000 0 0
TRAF6 0.007 0.016 -9999 0 -0.26 1 1
RAC1 0.013 0 -9999 0 -10000 0 0
mol:LPS 0 0 -9999 0 -10000 0 0
CAMK2B -0.14 0.28 -9999 0 -0.64 72 72
CCM2 0.013 0 -9999 0 -10000 0 0
CaM/Ca2+/CAMKIIB -0.097 0.18 -9999 0 -0.41 72 72
MAPK11 0.013 0 -9999 0 -10000 0 0
response to DNA damage stimulus 0 0 -9999 0 -10000 0 0
CaM/Ca2+/CAMKIIB/ASK1 -0.069 0.17 -9999 0 -0.43 30 30
OSM/MEKK3 0.019 0 -9999 0 -10000 0 0
TAOK1 0.004 0.073 -9999 0 -0.41 9 9
TAOK2 0.017 0 -9999 0 -10000 0 0
TAOK3 0.017 0 -9999 0 -10000 0 0
MAP3K7IP1 0 0 -9999 0 -10000 0 0
MAPK14 0.013 0 -9999 0 -10000 0 0
MAP3K7IP2 0 0 -9999 0 -10000 0 0
MAP3K5 0.01 0.042 -9999 0 -0.72 1 1
MAP3K10 0.011 0.034 -9999 0 -0.58 1 1
MAP3K3 0.013 0 -9999 0 -10000 0 0
TRX/ASK1 0.013 0.031 -9999 0 -0.46 1 1
GADD45/MTK1/MTK1 -0.016 0.075 -9999 0 -0.4 8 8
EPO signaling pathway

Figure S94.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S94.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.014 0.13 -10000 0 -0.55 1 1
CRKL -0.005 0.11 -10000 0 -0.58 1 1
mol:DAG 0.002 0.11 -10000 0 -0.47 2 2
HRAS 0.022 0.099 -10000 0 -0.47 1 1
MAPK8 -0.017 0.12 -10000 0 -0.42 4 4
RAP1A -0.004 0.11 -10000 0 -0.58 1 1
GAB1 -0.004 0.11 -10000 0 -0.49 2 2
MAPK14 -0.014 0.12 -10000 0 -0.4 5 5
EPO -0.066 0.2 -10000 0 -0.59 39 39
PLCG1 0.001 0.11 -10000 0 -0.48 2 2
EPOR/TRPC2/IP3 Receptors 0.005 0.059 -10000 0 -0.58 3 3
RAPGEF1 0.013 0 -10000 0 -10000 0 0
EPO/EPOR (dimer)/SOCS3 -0.026 0.13 -10000 0 -0.44 6 6
GAB1/SHC/GRB2/SOS1 -0.033 0.078 -10000 0 -0.5 1 1
EPO/EPOR (dimer) -0.041 0.16 -10000 0 -0.43 42 42
IRS2 -0.012 0.12 -10000 0 -0.6 2 2
STAT1 -0.001 0.14 -10000 0 -0.58 6 6
STAT5B 0.002 0.11 -10000 0 -0.53 1 1
cell proliferation -0.009 0.11 -10000 0 -10000 0 0
GAB1/SHIP/PIK3R1/SHP2/SHC -0.04 0.1 -10000 0 -0.6 4 4
TEC -0.01 0.12 -10000 0 -0.64 3 3
SOCS3 0.01 0.042 -10000 0 -0.72 1 1
STAT1 (dimer) -0.001 0.13 -10000 0 -0.56 6 6
JAK2 0.004 0.059 -10000 0 -0.58 3 3
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
EPO/EPOR (dimer)/JAK2 -0.001 0.12 -10000 0 -0.52 2 2
EPO/EPOR -0.041 0.16 -10000 0 -0.43 42 42
LYN 0.011 0.042 -10000 0 -0.72 1 1
TEC/VAV2 -0.004 0.12 -10000 0 -0.62 3 3
elevation of cytosolic calcium ion concentration 0.005 0.059 -10000 0 -0.58 3 3
SHC1 0.013 0 -10000 0 -10000 0 0
EPO/EPOR (dimer)/LYN -0.021 0.13 -10000 0 -0.44 7 7
mol:IP3 0.002 0.11 -10000 0 -0.47 2 2
PI3K regualtory subunit polypeptide 1/IRS2/SHIP -0.009 0.14 -10000 0 -0.62 6 6
SH2B3 0.007 0.043 -10000 0 -0.72 1 1
NFKB1 -0.014 0.12 -10000 0 -0.42 2 2
EPO/EPOR (dimer)/JAK2/SOCS3 -0.03 0.078 0.3 1 -0.34 4 5
PTPN6 -0.012 0.12 -10000 0 -0.52 2 2
TEC/VAV2/GRB2 0.002 0.12 -10000 0 -0.6 3 3
EPOR 0.005 0.059 -10000 0 -0.58 3 3
INPP5D -0.005 0.11 -10000 0 -0.67 8 8
mol:GDP -0.033 0.079 -10000 0 -0.51 1 1
SOS1 0.013 0 -10000 0 -10000 0 0
PLCG2 0.013 0 -10000 0 -10000 0 0
CRKL/CBL/C3G 0.01 0.11 -10000 0 -0.54 1 1
VAV2 -0.006 0.11 -10000 0 -0.58 1 1
CBL -0.004 0.11 -10000 0 -0.58 1 1
SHC/Grb2/SOS1 -0.036 0.084 -10000 0 -0.54 1 1
STAT5A 0.002 0.11 -10000 0 -0.49 2 2
GRB2 0.013 0 -10000 0 -10000 0 0
STAT5 (dimer) 0.013 0.13 -10000 0 -0.54 2 2
LYN/PLCgamma2 0.017 0.033 -10000 0 -0.54 1 1
PTPN11 0.013 0 -10000 0 -10000 0 0
BTK -0.023 0.15 -10000 0 -0.64 9 9
BCL2 -0.012 0.2 -10000 0 -0.94 7 7
Retinoic acid receptors-mediated signaling

Figure S95.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S95.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.013 0 -10000 0 -10000 0 0
HDAC3 0.013 0 -10000 0 -10000 0 0
VDR 0.01 0.042 -10000 0 -0.72 1 1
Cbp/p300/PCAF -0.005 0.046 -10000 0 -0.46 3 3
EP300 0.013 0 -10000 0 -10000 0 0
RARs/AIB1/Cbp/p300/PCAF/9cRA 0.014 0.079 -10000 0 -0.42 4 4
KAT2B 0.005 0.073 -10000 0 -0.72 3 3
MAPK14 0.013 0 -10000 0 -10000 0 0
AKT1 0.002 0.1 0.23 14 -0.31 15 29
RAR alpha/9cRA/Cyclin H -0.014 0.049 -10000 0 -10000 0 0
mol:9cRA 0 0 -10000 0 -10000 0 0
RARs/Src-1/Cbp/p300/PCAF/9cRA 0.008 0.086 -10000 0 -0.4 5 5
CDC2 0.001 0.001 -10000 0 -10000 0 0
response to UV 0.001 0.002 -10000 0 -10000 0 0
RAR alpha/Jnk1 0.004 0.068 -10000 0 -0.59 2 2
NCOR2 0.013 0 -10000 0 -10000 0 0
VDR/VDR/Vit D3 0.008 0.032 -10000 0 -0.55 1 1
RXRs/RARs/NRIP1/9cRA -0.005 0.12 -10000 0 -0.56 4 4
NCOA2 0.001 0.094 -10000 0 -0.72 5 5
NCOA3 0.013 0 -10000 0 -10000 0 0
NCOA1 0.013 0 -10000 0 -10000 0 0
VDR/VDR/DNA 0.01 0.042 -10000 0 -0.72 1 1
RARG 0.011 0.042 -10000 0 -0.72 1 1
RAR gamma1/9cRA 0.014 0.029 -10000 0 -0.47 1 1
MAPK3 0.013 0.001 -10000 0 -10000 0 0
MAPK1 0.013 0 -10000 0 -10000 0 0
MAPK8 0.009 0.06 -10000 0 -0.72 2 2
mol:Vit D3 0 0 -10000 0 -10000 0 0
RXRs/VDR/DNA/Vit D3 -0.037 0.083 -10000 0 -0.51 3 3
RARA 0.007 0.064 -10000 0 -0.28 5 5
negative regulation of phosphoinositide 3-kinase cascade 0 0 -10000 0 -10000 0 0
RARs/TIF2/Cbp/p300/PCAF/9cRA 0.003 0.1 -10000 0 -0.49 6 6
PRKCA 0.007 0.081 -10000 0 -0.69 4 4
RXRs/RARs/NRIP1/9cRA/HDAC1 -0.013 0.12 -10000 0 -0.54 6 6
RXRG -0.06 0.16 -10000 0 -0.44 28 28
RXRA 0.015 0.062 -10000 0 -10000 0 0
RXRB 0 0.085 -10000 0 -0.4 3 3
VDR/Vit D3/DNA 0.008 0.032 -10000 0 -0.55 1 1
RBP1 -0.041 0.19 -10000 0 -0.7 23 23
CRBP1/9-cic-RA -0.032 0.14 -10000 0 -0.53 23 23
RARB -0.057 0.21 -10000 0 -0.65 33 33
PRKCG -0.035 0.16 -10000 0 -0.58 24 24
MNAT1 0.013 0 -10000 0 -10000 0 0
RAR alpha/RXRs -0.005 0.13 -10000 0 -0.52 4 4
RXRs/RARs/SMRT(N-CoR2)/9cRA 0 0.11 -10000 0 -0.48 4 4
proteasomal ubiquitin-dependent protein catabolic process 0.011 0.086 -10000 0 -0.45 4 4
RXRs/RARs/NRIP1/9cRA/HDAC3 -0.013 0.12 -10000 0 -0.54 6 6
positive regulation of DNA binding -0.014 0.047 -10000 0 -10000 0 0
NRIP1 -0.01 0.13 -10000 0 -1 2 2
RXRs/RARs -0.016 0.12 -10000 0 -0.51 6 6
RXRs/RXRs/DNA/9cRA -0.037 0.086 -10000 0 -0.53 3 3
PRKACA 0.013 0 -10000 0 -10000 0 0
CDK7 0.013 0 -10000 0 -10000 0 0
TFIIH 0 0 -10000 0 -10000 0 0
RAR alpha/9cRA -0.009 0.03 -10000 0 -10000 0 0
CCNH 0.013 0 -10000 0 -10000 0 0
CREBBP 0.013 0 -10000 0 -10000 0 0
RAR gamma2/9cRA -0.001 0.021 -10000 0 -10000 0 0
Signaling events mediated by VEGFR1 and VEGFR2

Figure S96.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S96.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaV beta3 Integrin -0.021 0.15 -9999 0 -0.56 21 21
AKT1 0.063 0.11 -9999 0 -0.69 5 5
PTK2B 0.009 0.16 -9999 0 -0.81 8 8
VEGFR2 homodimer/Frs2 0.015 0.12 -9999 0 -0.84 5 5
CAV1 -0.049 0.2 -9999 0 -0.71 26 26
CALM1 0.013 0 -9999 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Frs2 0.023 0.11 -9999 0 -0.78 5 5
endothelial cell proliferation 0.055 0.13 -9999 0 -0.67 5 5
mol:Ca2+ 0.035 0.11 -9999 0 -0.7 5 5
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Rac 0.033 0.1 -9999 0 -0.74 5 5
RP11-342D11.1 0.026 0.11 -9999 0 -0.71 5 5
CDH5 0.003 0.08 -9999 0 -0.69 4 4
VEGFA homodimer 0 0.018 -9999 0 -10000 0 0
SHC1 0.013 0 -9999 0 -10000 0 0
SHC2 -0.02 0.15 -9999 0 -0.7 14 14
HRAS/GDP -0.016 0.087 -9999 0 -0.59 6 6
SH2D2A -0.002 0.1 -9999 0 -0.72 6 6
VEGFR2 homodimer/VEGFA homodimer/SHP1/eNOS -0.019 0.1 -9999 0 -0.76 5 5
VEGFR2 homodimer/VEGFA homodimer/TsAd 0.017 0.12 -9999 0 -0.78 5 5
VEGFR1 homodimer 0.008 0.06 -9999 0 -0.72 2 2
SHC/GRB2/SOS1 -0.017 0.093 -9999 0 -0.67 5 5
GRB10 0.027 0.14 -9999 0 -0.7 11 11
PTPN11 0.013 0 -9999 0 -10000 0 0
GRB2 0.013 0 -9999 0 -10000 0 0
PAK1 0.011 0.034 -9999 0 -0.58 1 1
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Cadherin/beta catenin -0.022 0.13 -9999 0 -0.86 6 6
HRAS 0.011 0.034 -9999 0 -0.58 1 1
VEGF/Rho/ROCK1/Integrin Complex 0.021 0.11 -9999 0 -0.53 7 7
HIF1A 0.013 0 -9999 0 -10000 0 0
FRS2 0.007 0.059 -9999 0 -0.58 3 3
oxygen and reactive oxygen species metabolic process -0.015 0.095 -9999 0 -0.73 5 5
mol:GTP 0 0 -9999 0 -10000 0 0
FLT4 -0.007 0.12 -9999 0 -0.66 9 9
Nck/Pak 0.017 0.025 -9999 0 -0.42 1 1
VEGFR2 homodimer/VEGFA homodimer/Fyn 0.022 0.12 -9999 0 -0.86 5 5
mol:GDP -0.016 0.09 -9999 0 -0.65 5 5
mol:NADP 0.055 0.1 -9999 0 -0.66 5 5
eNOS/Hsp90 0.059 0.097 -9999 0 -0.61 5 5
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
mol:IP3 0.035 0.11 -9999 0 -0.72 5 5
HIF1A/ARNT 0.019 0 -9999 0 -10000 0 0
SHB 0.008 0.06 -9999 0 -0.72 2 2
VEGFA 0.011 0.036 -9999 0 -0.58 1 1
VEGFC -0.063 0.21 -9999 0 -0.66 34 34
FAK1/Vinculin 0.034 0.14 -9999 0 -0.76 7 7
mol:Ca ++ 0 0 -9999 0 -10000 0 0
RHOA 0.013 0 -9999 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.002 0.17 -9999 0 -0.86 8 8
PTPN6 0.01 0.042 -9999 0 -0.72 1 1
EPAS1 0.015 0.051 -9999 0 -0.37 5 5
mol:L-citrulline 0.055 0.1 -9999 0 -0.66 5 5
ITGAV 0.005 0.073 -9999 0 -0.72 3 3
PIK3CA 0.013 0 -9999 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Frs2/GRB2 0.03 0.11 -9999 0 -0.74 5 5
VEGFR2 homodimer/VEGFA homodimer 0.028 0.12 -9999 0 -0.78 5 5
VEGFR2/3 heterodimer 0.007 0.15 -9999 0 -1 5 5
VEGFB 0.013 0 -9999 0 -10000 0 0
MAPK11 0.037 0.11 -9999 0 -0.72 5 5
VEGFR2 homodimer 0.017 0.12 -9999 0 -0.94 5 5
FLT1 0.008 0.06 -9999 0 -0.72 2 2
NEDD4 0.013 0.011 -9999 0 -10000 0 0
MAPK3 0.028 0.11 -9999 0 -0.69 5 5
MAPK1 0.028 0.11 -9999 0 -0.69 5 5
VEGFA145/NRP2 -0.01 0.07 -9999 0 -0.5 6 6
VEGFR1/2 heterodimer 0.016 0.14 -9999 0 -1 5 5
KDR 0.017 0.13 -9999 0 -0.95 5 5
VEGFA165/NRP1/VEGFR2 homodimer 0.028 0.12 -9999 0 -0.79 5 5
SRC 0.013 0 -9999 0 -10000 0 0
platelet activating factor biosynthetic process 0.03 0.11 -9999 0 -0.7 5 5
PI3K 0.05 0.14 -9999 0 -0.9 5 5
VEGFR2 homodimer/VEGFA homodimer/NCK1 0.026 0.11 -9999 0 -0.78 5 5
FES 0.031 0.13 -9999 0 -0.88 5 5
GAB1 -0.018 0.11 -9999 0 -0.84 5 5
VEGFR2 homodimer/VEGFA homodimer/Src 0.026 0.11 -9999 0 -0.78 5 5
CTNNB1 0.008 0.06 -9999 0 -0.72 2 2
SOS1 0.013 0 -9999 0 -10000 0 0
ARNT 0.013 0 -9999 0 -10000 0 0
eNOS/Caveolin-1 0.03 0.14 -9999 0 -0.63 5 5
VEGFR2 homodimer/VEGFA homodimer/Yes 0.026 0.11 -9999 0 -0.78 5 5
PI3K/GAB1 0.064 0.11 -9999 0 -0.71 5 5
VEGFR2 homodimer/VEGFA homodimer/Frs2/Nck/Pak -0.018 0.097 -9999 0 -0.71 5 5
PRKACA 0.013 0 -9999 0 -10000 0 0
VEGFR2/3 heterodimer/VEGFC homodimer -0.031 0.2 -9999 0 -0.96 7 7
HSP90AA1 0.013 0 -9999 0 -10000 0 0
CDC42 0.035 0.11 -9999 0 -0.73 5 5
actin cytoskeleton reorganization -0.025 0.12 -9999 0 -0.77 5 5
PTK2 0.027 0.15 -9999 0 -0.84 7 7
EDG1 0.026 0.11 -9999 0 -0.71 5 5
mol:DAG 0.035 0.11 -9999 0 -0.72 5 5
CaM/Ca2+ -0.017 0.091 -9999 0 -0.66 5 5
MAP2K3 0.036 0.12 -9999 0 -0.68 6 6
VEGFR2 homodimer/VEGFA homodimer/GRB10/NEDD4 0.027 0.15 -9999 0 -0.74 10 10
PLCG1 0.035 0.11 -9999 0 -0.73 5 5
VEGFR2 homodimer/VEGFA homodimer/Src/Shb 0.03 0.11 -9999 0 -0.74 5 5
IQGAP1 0.013 0 -9999 0 -10000 0 0
YES1 0.013 0 -9999 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/SHP2 0.026 0.11 -9999 0 -0.78 5 5
VEGFR2 homodimer/VEGFA homodimer/SHP1 0.025 0.11 -9999 0 -0.78 5 5
cell migration 0.056 0.13 -9999 0 -0.71 5 5
mol:PI-3-4-5-P3 0.05 0.12 -9999 0 -0.79 5 5
FYN 0.006 0.069 -9999 0 -0.68 3 3
VEGFB/NRP1 0.033 0.1 -9999 0 -0.67 5 5
mol:NO 0.055 0.1 -9999 0 -0.66 5 5
PXN 0.013 0 -9999 0 -10000 0 0
HRAS/GTP -0.016 0.087 -9999 0 -0.59 6 6
VEGFR2 homodimer/VEGFA homodimer/GRB10 0.027 0.15 -9999 0 -0.74 10 10
VHL 0.013 0 -9999 0 -10000 0 0
ITGB3 -0.034 0.18 -9999 0 -0.7 20 20
NOS3 0.055 0.12 -9999 0 -0.8 5 5
VEGFR2 homodimer/VEGFA homodimer/Sck 0.006 0.14 -9999 0 -0.75 6 6
RAC1 0.013 0 -9999 0 -10000 0 0
PRKCA 0.036 0.12 -9999 0 -0.74 5 5
PRKCB 0.007 0.15 -9999 0 -0.72 6 6
VCL 0.013 0 -9999 0 -10000 0 0
VEGFA165/NRP1 0.027 0.11 -9999 0 -0.71 5 5
VEGFR1/2 heterodimer/VEGFA homodimer 0.024 0.13 -9999 0 -0.94 5 5
VEGFA165/NRP2 -0.01 0.07 -9999 0 -0.5 6 6
MAPKKK cascade 0.049 0.13 -9999 0 -0.63 10 10
NRP2 0.001 0.091 -9999 0 -0.7 5 5
VEGFC homodimer -0.063 0.21 -9999 0 -0.66 34 34
NCK1 0.013 0 -9999 0 -10000 0 0
ROCK1 0.013 0 -9999 0 -10000 0 0
FAK1/Paxillin 0.034 0.14 -9999 0 -0.76 7 7
MAP3K13 0.031 0.12 -9999 0 -0.72 6 6
PDPK1 0.056 0.11 -9999 0 -0.67 5 5
TCGA08_rtk_signaling

Figure S97.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S97.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA -0.039 0.18 -10000 0 -0.69 22 22
HRAS 0.011 0.034 -10000 0 -0.58 1 1
EGFR -0.019 0.14 -10000 0 -0.63 15 15
AKT 0.029 0.057 -10000 0 -0.46 3 3
FOXO3 0.01 0.042 -10000 0 -0.72 1 1
AKT1 0.013 0 -10000 0 -10000 0 0
FOXO1 0.01 0.042 -10000 0 -0.72 1 1
AKT3 0.001 0.087 -10000 0 -0.67 5 5
FOXO4 0.008 0.06 -10000 0 -0.72 2 2
MET -0.004 0.11 -10000 0 -0.72 7 7
PIK3CA 0.013 0 -10000 0 -10000 0 0
PIK3CB 0.013 0 -10000 0 -10000 0 0
NRAS 0.013 0 -10000 0 -10000 0 0
PIK3CG -0.048 0.2 -10000 0 -0.67 27 27
PIK3R3 0.002 0.084 -10000 0 -0.64 5 5
PIK3R2 0.013 0 -10000 0 -10000 0 0
NF1 0.013 0 -10000 0 -10000 0 0
RAS 0.001 0.064 -10000 0 -0.28 3 3
ERBB2 0.007 0.059 -10000 0 -0.58 3 3
proliferation/survival/translation -0.02 0.047 0.24 4 -10000 0 4
PI3K 0.002 0.076 0.21 1 -0.26 9 10
PIK3R1 0.008 0.054 -10000 0 -0.66 2 2
KRAS 0.013 0 -10000 0 -10000 0 0
FOXO 0.039 0.033 -10000 0 -0.33 1 1
AKT2 0.013 0 -10000 0 -10000 0 0
PTEN 0.01 0.042 -10000 0 -0.72 1 1
Stabilization and expansion of the E-cadherin adherens junction

Figure S98.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S98.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
adherens junction organization 0.025 0.042 -10000 0 -10000 0 0
epithelial cell differentiation -0.006 0.05 -10000 0 -0.39 5 5
CYFIP2 -0.026 0.16 -10000 0 -0.68 17 17
ENAH 0.055 0.048 -10000 0 -10000 0 0
EGFR -0.019 0.14 -10000 0 -0.63 15 15
EPHA2 0.005 0.073 -10000 0 -0.72 3 3
MYO6 0.028 0.057 -10000 0 -10000 0 0
CTNNB1 0.008 0.06 -10000 0 -0.72 2 2
ABI1/Sra1/Nap1 -0.024 0.099 -10000 0 -0.46 11 11
AQP5 -0.14 0.21 -10000 0 -0.56 51 51
CTNND1 0.013 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 0.03 0.051 -10000 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion -0.028 0.14 -10000 0 -0.74 1 1
EGF -0.14 0.29 -10000 0 -0.66 70 70
NCKAP1 0.013 0 -10000 0 -10000 0 0
AQP3 -0.082 0.19 -10000 0 -0.55 40 40
cortical microtubule organization -0.006 0.05 -10000 0 -0.39 5 5
GO:0000145 0.028 0.049 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.007 0.051 -10000 0 -0.4 5 5
MLLT4 0.013 0 -10000 0 -10000 0 0
ARF6/GDP -0.009 0.05 -10000 0 -10000 0 0
ARF6 0.013 0 -10000 0 -10000 0 0
Ephrin A1/EPHA2/NCK1/GIT1 0.027 0.049 -10000 0 -0.42 3 3
mol:Ca2+ 0 0 -10000 0 -10000 0 0
VASP 0.038 0.056 -10000 0 -10000 0 0
PVRL2 0.013 0 -10000 0 -10000 0 0
ZYX 0.03 0.052 -10000 0 -10000 0 0
ARF6/GTP -0.005 0.041 -10000 0 -10000 0 0
CDH1 0.005 0.073 -10000 0 -0.72 3 3
EGFR/EGFR/EGF/EGF -0.094 0.16 -10000 0 -0.64 5 5
RhoA/GDP -0.006 0.047 -10000 0 -10000 0 0
actin cytoskeleton organization 0.034 0.054 -10000 0 -10000 0 0
IGF-1R heterotetramer 0.013 0 -10000 0 -10000 0 0
GIT1 0.013 0 -10000 0 -10000 0 0
IGF1R 0.013 0 -10000 0 -10000 0 0
IGF1 -0.078 0.23 -10000 0 -0.64 42 42
DIAPH1 -0.028 0.13 -10000 0 -0.66 11 11
Wnt receptor signaling pathway 0.006 0.05 0.39 5 -10000 0 5
RHOA 0.013 0 -10000 0 -10000 0 0
RhoA/GTP -0.009 0.051 -10000 0 -10000 0 0
CTNNA1 0.013 0 -10000 0 -10000 0 0
VCL 0.034 0.056 -10000 0 -10000 0 0
EFNA1 0.011 0.034 -10000 0 -0.58 1 1
LPP 0.031 0.067 -10000 0 -10000 0 0
Ephrin A1/EPHA2 -0.01 0.059 -10000 0 -10000 0 0
SEC6/SEC8 -0.005 0.041 -10000 0 -10000 0 0
MGAT3 -0.029 0.14 -10000 0 -0.76 1 1
HGF/MET -0.05 0.12 -10000 0 -0.64 1 1
HGF -0.064 0.22 -10000 0 -0.67 34 34
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.025 0.043 -10000 0 -10000 0 0
actin cable formation 0.064 0.054 -10000 0 -10000 0 0
KIAA1543 0.015 0.12 -10000 0 -0.81 4 4
KIFC3 0.026 0.066 -10000 0 -10000 0 0
NCK1 0.013 0 -10000 0 -10000 0 0
EXOC3 0.013 0 -10000 0 -10000 0 0
ACTN1 0.024 0.07 -10000 0 -10000 0 0
NCK1/GIT1 0.019 0 -10000 0 -10000 0 0
mol:GDP -0.006 0.05 -10000 0 -0.39 5 5
EXOC4 0.013 0 -10000 0 -10000 0 0
STX4 0.03 0.052 -10000 0 -10000 0 0
PIP5K1C 0.03 0.052 -10000 0 -10000 0 0
LIMA1 0.013 0 -10000 0 -10000 0 0
ABI1 0.013 0 -10000 0 -10000 0 0
ROCK1 0.051 0.054 -10000 0 -10000 0 0
adherens junction assembly 0.026 0.13 -10000 0 -0.7 5 5
IGF-1R heterotetramer/IGF1 -0.048 0.12 -10000 0 -0.64 1 1
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.019 0 -10000 0 -10000 0 0
MET -0.004 0.11 -10000 0 -0.72 7 7
PLEKHA7 0.019 0.088 -10000 0 -0.76 1 1
mol:GTP -0.005 0.045 -10000 0 -0.42 3 3
establishment of epithelial cell apical/basal polarity 0.053 0.047 -10000 0 -10000 0 0
cortical actin cytoskeleton stabilization 0.025 0.042 -10000 0 -10000 0 0
regulation of cell-cell adhesion 0.034 0.054 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.025 0.043 -10000 0 -10000 0 0
Insulin Pathway

Figure S99.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S99.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CBL/APS/CAP -0.03 0.1 -9999 0 -0.74 1 1
TC10/GTP -0.019 0.075 -9999 0 -10000 0 0
Insulin Receptor/Insulin/IRS1/Shp2 -0.013 0.073 -9999 0 -0.43 9 9
HRAS 0.011 0.034 -9999 0 -0.58 1 1
APS homodimer -0.001 0.1 -9999 0 -0.7 6 6
GRB14 -0.12 0.27 -9999 0 -0.66 58 58
FOXO3 -0.016 0.065 -9999 0 -0.75 2 2
AKT1 -0.028 0.15 -9999 0 -0.59 4 4
INSR 0.012 0.042 -9999 0 -0.72 1 1
Insulin Receptor/Insulin 0.033 0.023 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
GRB10 -0.001 0.1 -9999 0 -0.7 6 6
SORBS1 -0.013 0.13 -9999 0 -0.64 12 12
CRK 0.013 0 -9999 0 -10000 0 0
PTPN1 0.032 0.022 -9999 0 -10000 0 0
CAV1 -0.022 0.16 -9999 0 -0.46 30 30
CBL/APS/CAP/Crk-II/C3G -0.021 0.083 -9999 0 -10000 0 0
Insulin Receptor/Insulin/IRS1/NCK2 -0.013 0.073 -9999 0 -0.43 9 9
mol:GDP 0 0 -9999 0 -10000 0 0
mol:PI-3-4-5-P3 -0.013 0.069 -9999 0 -0.38 9 9
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B 0.028 0.059 -9999 0 -0.6 1 1
RPS6KB1 -0.018 0.14 -9999 0 -0.53 4 4
PARD6A 0.002 0.08 -9999 0 -0.61 5 5
CBL 0.013 0 -9999 0 -10000 0 0
tumor necrosis factor-mediated signaling pathway 0 0 -9999 0 -10000 0 0
DOK1 -0.007 0.093 -9999 0 -0.92 3 3
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
Insulin Receptor/Insuli/IRS1/GRB2/Shc -0.058 0.12 -9999 0 -0.54 4 4
HRAS/GTP -0.018 0.072 -9999 0 -10000 0 0
Insulin Receptor 0.012 0.042 -9999 0 -0.72 1 1
Insulin Receptor/Insuli/IRS1/GRB2/SHC -0.012 0.068 -9999 0 -0.4 9 9
PRKCI -0.016 0.032 -9999 0 -10000 0 0
Insulin Receptor/Insulin/GRB14/PDK1 -0.071 0.14 -9999 0 -0.65 4 4
SHC1 0.013 0 -9999 0 -10000 0 0
negative regulation of MAPKKK cascade -0.006 0.079 -9999 0 -0.79 3 3
PI3K -0.014 0.07 -9999 0 -0.38 9 9
NCK2 0.013 0 -9999 0 -10000 0 0
RHOQ 0.013 0 -9999 0 -10000 0 0
mol:H2O2 0 0.003 -9999 0 -10000 0 0
HRAS/GDP 0.008 0.025 -9999 0 -0.43 1 1
AKT2 -0.028 0.15 -9999 0 -0.59 4 4
PRKCZ -0.018 0.046 -9999 0 -0.58 1 1
SH2B2 -0.001 0.1 -9999 0 -0.7 6 6
SHC/SHIP 0.011 0.091 -9999 0 -0.38 13 13
F2RL2 -0.063 0.22 -9999 0 -0.68 33 33
TRIP10 0.013 0 -9999 0 -10000 0 0
Insulin Receptor/Insulin/Shc -0.001 0.023 -9999 0 -0.41 1 1
TC10/GTP/CIP4/Exocyst 0 0 -9999 0 -10000 0 0
Insulin Receptor/Insulin/SHC/GRB2/Sos1 -0.001 0.021 -9999 0 -0.37 1 1
RAPGEF1 0.013 0 -9999 0 -10000 0 0
RASA1 0.013 0 -9999 0 -10000 0 0
NCK1 0.013 0 -9999 0 -10000 0 0
CBL/APS/CAP/Crk-II 0.009 0.097 -9999 0 -0.42 10 10
TC10/GDP 0.009 0 -9999 0 -10000 0 0
Insulin Receptor/Insulin/SHC/GRB10 -0.01 0.063 -9999 0 -0.42 7 7
INPP5D 0.003 0.096 -9999 0 -0.4 14 14
SOS1 0.013 0 -9999 0 -10000 0 0
SGK1 -0.009 0.066 -9999 0 -1.1 1 1
mol:cAMP 0 0 -9999 0 -10000 0 0
PTPN11 0.013 0 -9999 0 -10000 0 0
IRS1 -0.007 0.12 -9999 0 -0.72 8 8
p62DOK/RasGAP -0.006 0.08 -9999 0 -0.8 3 3
INS 0.003 0.003 -9999 0 -10000 0 0
mol:PI-3-4-P2 0.003 0.095 -9999 0 -0.4 14 14
GRB2 0.013 0 -9999 0 -10000 0 0
EIF4EBP1 -0.02 0.14 -9999 0 -0.52 5 5
PTPRA 0.014 0.002 -9999 0 -10000 0 0
PIK3CA 0.013 0 -9999 0 -10000 0 0
TC10/GTP/CIP4 0 0 -9999 0 -10000 0 0
PDPK1 0.013 0 -9999 0 -10000 0 0
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos 0.023 0.057 -9999 0 -0.3 9 9
Insulin Receptor/Insulin/IRS1 -0.013 0.075 -9999 0 -0.44 9 9
Insulin Receptor/Insulin/IRS3 -0.002 0.031 -9999 0 -0.55 1 1
Par3/Par6 -0.045 0.12 -9999 0 -0.4 23 23
Rapid glucocorticoid signaling

Figure S100.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S100.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Gs family/GDP/Gbeta gamma -0.031 0.11 -10000 0 -0.42 17 17
MAPK9 0.008 0 -10000 0 -10000 0 0
adrenocorticotropin secretion 0 0 -10000 0 -10000 0 0
GNB1/GNG2 -0.007 0.058 -10000 0 -0.45 5 5
GNB1 0.013 0 -10000 0 -10000 0 0
regulation of calcium ion transport via voltage-gated calcium channel activity 0 0 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
MAPK14 0.008 0 -10000 0 -10000 0 0
Gs family/GTP -0.019 0.1 -10000 0 -0.4 20 20
EntrezGene:2778 0 0 -10000 0 -10000 0 0
vasopressin secretion 0 0 -10000 0 -10000 0 0
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
ChemicalAbstracts:86-01-1 0 0 -10000 0 -10000 0 0
glutamate secretion 0.006 0.025 0.098 20 -10000 0 20
GNAL -0.033 0.17 -10000 0 -0.68 20 20
GNG2 0.001 0.091 -10000 0 -0.7 5 5
CRH 0 0 -10000 0 -10000 0 0
mol:cortisol 0 0 -10000 0 -10000 0 0
MAPK8 0.006 0.035 -10000 0 -0.42 2 2
MAPK11 0.008 0 -10000 0 -10000 0 0
S1P4 pathway

Figure S101.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S101.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -9999 0 -10000 0 0
GNAO1 0.001 0.091 -9999 0 -0.7 5 5
CDC42/GTP -0.034 0.083 -9999 0 -0.48 3 3
PLCG1 -0.002 0.1 -9999 0 -0.49 3 3
mol:GTP 0 0 -9999 0 -10000 0 0
GNAI2 0.013 0 -9999 0 -10000 0 0
GNAI3 0.013 0 -9999 0 -10000 0 0
G12/G13 0.019 0 -9999 0 -10000 0 0
cell migration -0.033 0.081 -9999 0 -0.47 3 3
S1PR5 0.01 0.042 -9999 0 -0.72 1 1
S1PR4 -0.033 0.17 -9999 0 -0.64 21 21
MAPK3 -0.002 0.1 -9999 0 -0.49 3 3
MAPK1 -0.002 0.1 -9999 0 -0.49 3 3
S1P/S1P5/Gi 0.007 0.08 -9999 0 -0.33 6 6
GNAI1 0.008 0.06 -9999 0 -0.72 2 2
CDC42/GDP 0.009 0 -9999 0 -10000 0 0
S1P/S1P5/G12 -0.002 0.027 -9999 0 -0.47 1 1
RHOA 0.005 0.094 -9999 0 -0.4 9 9
S1P/S1P4/Gi -0.01 0.1 -9999 0 -0.48 4 4
mol:GDP 0 0 -9999 0 -10000 0 0
GNAZ -0.048 0.19 -9999 0 -0.62 29 29
S1P/S1P4/G12/G13 -0.003 0.1 -9999 0 -0.43 9 9
GNA12 0.013 0 -9999 0 -10000 0 0
GNA13 0.013 0 -9999 0 -10000 0 0
CDC42 0.013 0 -9999 0 -10000 0 0
Signaling events mediated by HDAC Class II

Figure S102.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S102.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G beta1gamma2/HDAC5 0.026 0.055 -9999 0 -0.42 4 4
HDAC3 0.013 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC4 0 0 -9999 0 -10000 0 0
GATA1/HDAC4 0.012 0.05 -9999 0 -0.42 4 4
GATA1/HDAC5 0.012 0.05 -9999 0 -0.42 4 4
GATA2/HDAC5 0.011 0.064 -9999 0 -0.54 4 4
HDAC5/BCL6/BCoR 0 0 -9999 0 -10000 0 0
HDAC9 -0.018 0.14 -9999 0 -0.7 13 13
Glucocorticoid receptor/Hsp90/HDAC6 0 0 -9999 0 -10000 0 0
HDAC4/ANKRA2 0.019 0 -9999 0 -10000 0 0
HDAC5/YWHAB 0.019 0 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1/Ubc9 0.021 0 -9999 0 -10000 0 0
GATA2 0.003 0.084 -9999 0 -0.72 4 4
HDAC4/RFXANK 0.019 0 -9999 0 -10000 0 0
BCOR 0.013 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
HDAC10 0.013 0 -9999 0 -10000 0 0
HDAC5 0.013 0 -9999 0 -10000 0 0
GNB1/GNG2 0.01 0.069 -9999 0 -0.52 5 5
Histones 0.027 0.062 -9999 0 -0.56 1 1
ADRBK1 0.013 0 -9999 0 -10000 0 0
HDAC4 0.013 0 -9999 0 -10000 0 0
XPO1 0.013 0 -9999 0 -10000 0 0
HDAC5/ANKRA2 0.019 0 -9999 0 -10000 0 0
HDAC4/Ubc9 0.019 0 -9999 0 -10000 0 0
HDAC7 0.013 0 -9999 0 -10000 0 0
HDAC5/14-3-3 E 0.019 0 -9999 0 -10000 0 0
TUBA1B 0.013 0 -9999 0 -10000 0 0
HDAC6 0.013 0 -9999 0 -10000 0 0
HDAC5/RFXANK 0.019 0 -9999 0 -10000 0 0
CAMK4 -0.037 0.18 -9999 0 -0.7 21 21
Tubulin/HDAC6 -0.013 0.07 -9999 0 -0.39 10 10
SUMO1 0.013 0 -9999 0 -10000 0 0
EntrezGene:9972 0 0 -9999 0 -10000 0 0
YWHAB 0.013 0 -9999 0 -10000 0 0
GATA1 0.003 0.068 -9999 0 -0.58 4 4
EntrezGene:8021 0 0 -9999 0 -10000 0 0
YWHAE 0.013 0 -9999 0 -10000 0 0
NR3C1 0.013 0 -9999 0 -10000 0 0
SUMO1/HDAC4 0.03 0 -9999 0 -10000 0 0
SRF 0.013 0 -9999 0 -10000 0 0
HDAC4/YWHAB 0.019 0 -9999 0 -10000 0 0
Tubulin 0.003 0.086 -9999 0 -0.46 10 10
HDAC4/14-3-3 E 0.019 0 -9999 0 -10000 0 0
GNB1 0.013 0 -9999 0 -10000 0 0
RANGAP1 0.013 0 -9999 0 -10000 0 0
BCL6/BCoR 0.019 0 -9999 0 -10000 0 0
HDAC4/HDAC3/SMRT (N-CoR2) 0 0 -9999 0 -10000 0 0
HDAC4/SRF -0.031 0.12 -9999 0 -0.45 21 21
HDAC4/ER alpha -0.052 0.17 -9999 0 -0.47 44 44
EntrezGene:23225 0 0 -9999 0 -10000 0 0
positive regulation of chromatin silencing 0.027 0.061 -9999 0 -0.55 1 1
cell motility -0.013 0.069 -9999 0 -0.38 10 10
EntrezGene:23636 0 0 -9999 0 -10000 0 0
UBE2I 0.013 0 -9999 0 -10000 0 0
HDAC7/HDAC3 0.019 0 -9999 0 -10000 0 0
BCL6 0.013 0 -9999 0 -10000 0 0
HDAC4/CaMK II delta B 0.013 0 -9999 0 -10000 0 0
Hsp90/HDAC6 0.019 0 -9999 0 -10000 0 0
ESR1 -0.081 0.23 -9999 0 -0.64 44 44
HDAC6/HDAC11 0.017 0.032 -9999 0 -0.54 1 1
Ran/GTP/Exportin 1 0.032 0 -9999 0 -10000 0 0
NPC 0 0 -9999 0 -10000 0 0
MEF2C -0.042 0.18 -9999 0 -0.6 27 27
RAN 0.013 0 -9999 0 -10000 0 0
HDAC4/MEF2C -0.027 0.086 -9999 0 -10000 0 0
GNG2 0.001 0.091 -9999 0 -0.7 5 5
NCOR2 0.013 0 -9999 0 -10000 0 0
TUBB2A -0.008 0.12 -9999 0 -0.63 10 10
HDAC11 0.01 0.042 -9999 0 -0.72 1 1
HSP90AA1 0.013 0 -9999 0 -10000 0 0
RANBP2 0.013 0 -9999 0 -10000 0 0
ANKRA2 0.013 0 -9999 0 -10000 0 0
RFXANK 0.013 0 -9999 0 -10000 0 0
nuclear import -0.028 0 -9999 0 -10000 0 0
Sphingosine 1-phosphate (S1P) pathway

Figure S103.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S103.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.013 0 -9999 0 -10000 0 0
SPHK1 0.013 0 -9999 0 -10000 0 0
GNAI2 0.013 0 -9999 0 -10000 0 0
mol:S1P 0.016 0.037 -9999 0 -0.34 1 1
GNAO1 0.001 0.091 -9999 0 -0.7 5 5
mol:Sphinganine-1-P 0.022 0 -9999 0 -10000 0 0
growth factor activity 0 0 -9999 0 -10000 0 0
S1P/S1P2/G12/G13 0.034 0.027 -9999 0 -10000 0 0
GNAI3 0.013 0 -9999 0 -10000 0 0
G12/G13 0.019 0 -9999 0 -10000 0 0
S1PR3 -0.021 0.15 -9999 0 -0.71 14 14
S1PR2 0.013 0 -9999 0 -10000 0 0
EDG1 0 0 -9999 0 -10000 0 0
S1P1/S1P -0.004 0.029 -9999 0 -0.29 1 1
S1PR5 0.01 0.042 -9999 0 -0.72 1 1
S1PR4 -0.033 0.17 -9999 0 -0.64 21 21
GNAI1 0.008 0.06 -9999 0 -0.72 2 2
S1P/S1P5/G12 0.026 0.038 -9999 0 -0.41 1 1
S1P/S1P3/Gq 0.005 0.11 -9999 0 -0.67 3 3
S1P/S1P4/Gi -0.003 0.1 -9999 0 -0.51 3 3
GNAQ 0.013 0 -9999 0 -10000 0 0
GNAZ -0.048 0.19 -9999 0 -0.62 29 29
GNA14 -0.024 0.16 -9999 0 -0.68 16 16
GNA15 0.013 0 -9999 0 -10000 0 0
GNA12 0.013 0 -9999 0 -10000 0 0
GNA13 0.013 0 -9999 0 -10000 0 0
GNA11 0.008 0.06 -9999 0 -0.72 2 2
ABCC1 -0.002 0.093 -9999 0 -0.6 7 7
Circadian rhythm pathway

Figure S104.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S104.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
chromatin modification 0.046 0.012 -9999 0 -10000 0 0
CLOCK 0.014 0.042 -9999 0 -0.72 1 1
TIMELESS/CRY2 0.041 0.013 -9999 0 -10000 0 0
DEC1/BMAL1 -0.027 0.14 -9999 0 -0.46 29 29
ATR 0.013 0 -9999 0 -10000 0 0
NR1D1 0.04 0.014 -9999 0 -10000 0 0
ARNTL 0.016 0 -9999 0 -10000 0 0
TIMELESS 0.04 0.014 -9999 0 -10000 0 0
NPAS2 0.006 0.084 -9999 0 -0.72 4 4
CRY2 0.013 0 -9999 0 -10000 0 0
mol:CO -0.014 0 -9999 0 -10000 0 0
CHEK1 0.013 0 -9999 0 -10000 0 0
mol:HEME 0.014 0 -9999 0 -10000 0 0
PER1 0.01 0.042 -9999 0 -0.72 1 1
BMAL/CLOCK/NPAS2 0.034 0.063 -9999 0 -0.46 5 5
BMAL1/CLOCK 0.03 0.069 -9999 0 -10000 0 0
S phase of mitotic cell cycle 0.046 0.012 -9999 0 -10000 0 0
TIMELESS/CHEK1/ATR 0.047 0.012 -9999 0 -10000 0 0
mol:NADPH 0.014 0 -9999 0 -10000 0 0
PER1/TIMELESS 0.04 0.028 -9999 0 -10000 0 0
PER1-2 / CRY1-2 0 0 -9999 0 -10000 0 0
DEC1 -0.052 0.19 -9999 0 -0.63 29 29
Aurora A signaling

Figure S105.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S105.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Aurora A/GADD45A 0.022 0.031 -9999 0 -0.35 1 1
BIRC5 0.006 0.069 -9999 0 -0.68 3 3
NFKBIA 0.027 0.023 -9999 0 -10000 0 0
CPEB1 -0.077 0.23 -9999 0 -0.65 41 41
AKT1 0.027 0.023 -9999 0 -10000 0 0
NDEL1 0.013 0 -9999 0 -10000 0 0
Aurora A/BRCA1 -0.002 0.019 -9999 0 -10000 0 0
NDEL1/TACC3 -0.001 0.017 -9999 0 -10000 0 0
GADD45A 0.011 0.034 -9999 0 -0.58 1 1
GSK3B 0.012 0.004 -9999 0 -10000 0 0
PAK1/Aurora A 0.022 0.031 -9999 0 -0.35 1 1
MDM2 0.011 0.034 -9999 0 -0.58 1 1
JUB 0.001 0.094 -9999 0 -0.72 5 5
TPX2 0.018 0.046 -9999 0 -0.55 2 2
TP53 0.003 0.093 -9999 0 -0.35 19 19
DLG7 0.017 0.023 -9999 0 -0.28 1 1
AURKAIP1 0.013 0 -9999 0 -10000 0 0
ARHGEF7 0.011 0.034 -9999 0 -0.58 1 1
G2 phase of mitotic cell cycle 0 0 -9999 0 -10000 0 0
Aurora A/NDEL1/TACC3 0.03 0.021 -9999 0 -10000 0 0
G2/M transition of mitotic cell cycle -0.002 0.019 -9999 0 -10000 0 0
AURKA 0.02 0.027 -9999 0 -0.33 1 1
AURKB -0.004 0.046 -9999 0 -0.53 2 2
CDC25B 0.024 0.029 -9999 0 -10000 0 0
G2/M transition checkpoint -0.009 0.057 -9999 0 -0.42 5 5
mRNA polyadenylation -0.051 0.13 -9999 0 -0.37 41 41
Aurora A/CPEB -0.052 0.13 -9999 0 -0.37 41 41
Aurora A/TACC1/TRAP/chTOG 0.034 0.04 -9999 0 -10000 0 0
BRCA1 0.013 0 -9999 0 -10000 0 0
centrosome duplication 0.022 0.031 -9999 0 -0.35 1 1
regulation of centrosome cycle -0.001 0.017 -9999 0 -10000 0 0
spindle assembly -0.004 0.035 -9999 0 -10000 0 0
TDRD7 0.013 0 -9999 0 -10000 0 0
Aurora A/RasGAP/Survivin -0.005 0.05 -9999 0 -0.59 2 2
CENPA 0.014 0.055 -9999 0 -0.66 2 2
Aurora A/PP2A 0.023 0.023 -9999 0 -10000 0 0
meiosis 0 0 -9999 0 -10000 0 0
protein catabolic process 0.022 0.044 -9999 0 -10000 0 0
negative regulation of DNA binding 0.003 0.093 -9999 0 -0.35 19 19
prophase 0 0 -9999 0 -10000 0 0
GIT1/beta-PIX 0.017 0.025 -9999 0 -0.42 1 1
RASA1 0.013 0 -9999 0 -10000 0 0
Ajuba/Aurora A -0.009 0.057 -9999 0 -0.43 5 5
mitotic prometaphase 0 0.003 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.02 0.027 -9999 0 -0.33 1 1
TACC1 0.01 0.042 -9999 0 -0.72 1 1
TACC3 0.013 0 -9999 0 -10000 0 0
Aurora A/Antizyme1 0.03 0.021 -9999 0 -10000 0 0
Aurora A/RasGAP 0.023 0.023 -9999 0 -10000 0 0
OAZ1 0.013 0 -9999 0 -10000 0 0
RAN 0.013 0 -9999 0 -10000 0 0
mitosis 0 0 -9999 0 -10000 0 0
PRKACA 0.012 0.004 -9999 0 -10000 0 0
GIT1 0.013 0 -9999 0 -10000 0 0
GIT1/beta-PIX/PAK1 -0.002 0.029 -9999 0 -0.35 2 2
Importin alpha/Importin beta/TPX2 0.018 0.046 -9999 0 -0.54 2 2
PPP2R5D 0.013 0 -9999 0 -10000 0 0
Aurora A/TPX2 0.028 0.055 -9999 0 -0.65 2 2
PAK1 0.011 0.034 -9999 0 -0.58 1 1
CKAP5 0.01 0.042 -9999 0 -0.72 1 1
S1P5 pathway

Figure S106.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S106.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
telencephalon oligodendrocyte cell migration 0.02 0.061 0.4 1 -10000 0 1
GNAI2 0.013 0 -10000 0 -10000 0 0
S1P/S1P5/G12 -0.002 0.027 -10000 0 -0.47 1 1
mol:GDP 0 0 -10000 0 -10000 0 0
GNAO1 0.001 0.091 -10000 0 -0.7 5 5
RhoA/GTP -0.02 0.062 -10000 0 -0.41 1 1
negative regulation of cAMP metabolic process 0.007 0.08 -10000 0 -0.33 6 6
GNAZ -0.048 0.19 -10000 0 -0.62 29 29
GNAI3 0.013 0 -10000 0 -10000 0 0
GNA12 0.013 0 -10000 0 -10000 0 0
S1PR5 0.01 0.042 -10000 0 -0.72 1 1
mol:GTP 0 0 -10000 0 -10000 0 0
S1P/S1P5/Gi 0.007 0.08 -10000 0 -0.33 6 6
RhoA/GDP 0.009 0 -10000 0 -10000 0 0
RHOA 0.013 0 -10000 0 -10000 0 0
GNAI1 0.008 0.06 -10000 0 -0.72 2 2
ceramide signaling pathway

Figure S107.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S107.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K4 0.013 0.098 -10000 0 -0.52 3 3
BAG4 0.011 0.034 -10000 0 -0.58 1 1
BAD 0.018 0.037 -10000 0 -10000 0 0
NFKBIA 0.013 0 -10000 0 -10000 0 0
BIRC3 -0.039 0.17 -10000 0 -0.61 25 25
BAX 0.018 0.037 -10000 0 -10000 0 0
EnzymeConsortium:3.1.4.12 0.005 0.027 -10000 0 -0.11 5 5
IKBKB 0.019 0.093 -10000 0 -0.49 3 3
MAP2K2 0.027 0.043 -10000 0 -10000 0 0
MAP2K1 0.027 0.043 -10000 0 -10000 0 0
SMPD1 0.01 0.032 -10000 0 -0.29 1 1
GO:0005551 0 0 -10000 0 -10000 0 0
FADD/Caspase 8 -0.007 0.13 -10000 0 -0.49 7 7
MAP2K4 0.024 0.038 -10000 0 -10000 0 0
protein ubiquitination 0.02 0.095 -10000 0 -0.5 3 3
EnzymeConsortium:2.7.1.37 0.031 0.047 -10000 0 -10000 0 0
response to UV 0 0.001 -10000 0 -10000 0 0
RAF1 0.022 0.043 -10000 0 -10000 0 0
CRADD 0.013 0 -10000 0 -10000 0 0
mol:ceramide 0.011 0.039 -10000 0 -0.16 3 3
I-kappa-B-alpha/RELA/p50/ubiquitin 0 0 -10000 0 -10000 0 0
MADD 0.013 0 -10000 0 -10000 0 0
MAP3K1 0.018 0.038 -10000 0 -10000 0 0
TRADD 0.013 0 -10000 0 -10000 0 0
RELA/p50 0.013 0 -10000 0 -10000 0 0
MAPK3 0.03 0.043 -10000 0 -10000 0 0
MAPK1 0.03 0.043 -10000 0 -10000 0 0
p50/RELA/I-kappa-B-alpha 0.019 0 -10000 0 -10000 0 0
FADD -0.015 0.13 -10000 0 -0.5 8 8
KSR1 0.017 0.043 -10000 0 -0.26 1 1
MAPK8 0.027 0.048 -10000 0 -0.36 2 2
TRAF2 0.009 0.048 -10000 0 -0.58 2 2
response to radiation 0 0 -10000 0 -10000 0 0
CHUK 0.019 0.093 -10000 0 -0.49 3 3
TNF R/SODD 0.017 0.025 -10000 0 -0.42 1 1
TNF -0.061 0.21 -10000 0 -0.67 33 33
CYCS 0.025 0.039 -10000 0 -10000 0 0
IKBKG 0.018 0.095 -10000 0 -0.49 3 3
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD 0.006 0.1 -10000 0 -0.56 3 3
RELA 0.013 0 -10000 0 -10000 0 0
RIPK1 0.013 0 -10000 0 -10000 0 0
AIFM1 0.025 0.039 0.15 3 -10000 0 3
TNF/TNF R/SODD -0.045 0.13 -10000 0 -0.46 19 19
TNFRSF1A 0.013 0 -10000 0 -10000 0 0
response to heat 0 0 -10000 0 -10000 0 0
CASP8 0.02 0.027 -10000 0 -10000 0 0
NSMAF 0.013 0.097 -10000 0 -0.52 3 3
response to hydrogen peroxide 0 0.001 -10000 0 -10000 0 0
BCL2 -0.037 0.17 -10000 0 -0.62 24 24
HIF-2-alpha transcription factor network

Figure S108.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S108.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MMP14 -0.002 0.015 -10000 0 -10000 0 0
oxygen homeostasis 0.01 0.015 -10000 0 -10000 0 0
TCEB2 0.011 0.034 -10000 0 -0.58 1 1
TCEB1 0.011 0.034 -10000 0 -0.58 1 1
VHL/Elongin B/Elongin C/HIF2A -0.027 0.075 -10000 0 -0.46 1 1
EPO 0.064 0.28 -10000 0 -0.85 10 10
FIH (dimer) 0.023 0.014 -10000 0 -10000 0 0
APEX1 0.022 0.014 -10000 0 -10000 0 0
SERPINE1 0.051 0.32 -10000 0 -0.91 12 12
FLT1 -0.015 0.14 -10000 0 -1.4 3 3
ADORA2A 0.096 0.24 -10000 0 -0.94 5 5
germ cell development 0.085 0.25 -10000 0 -0.78 8 8
SLC11A2 0.1 0.23 -10000 0 -0.8 5 5
BHLHE40 0.1 0.23 -10000 0 -0.8 5 5
HIF1AN 0.023 0.014 -10000 0 -10000 0 0
HIF2A/ARNT/SIRT1 -0.045 0.1 -10000 0 -0.53 5 5
ETS1 0.022 0.062 -10000 0 -0.73 2 2
CITED2 -0.008 0.053 -10000 0 -0.55 1 1
KDR -0.025 0.19 -10000 0 -1.3 6 6
PGK1 0.1 0.23 -10000 0 -0.8 5 5
SIRT1 0.012 0.003 -10000 0 -10000 0 0
response to hypoxia -0.001 0.005 -10000 0 -10000 0 0
HIF2A/ARNT 0.1 0.26 -10000 0 -0.93 6 6
EPAS1 0.059 0.13 -10000 0 -0.45 5 5
SP1 0.02 0 -10000 0 -10000 0 0
ABCG2 0.087 0.26 -10000 0 -0.95 8 8
EFNA1 0.1 0.23 -10000 0 -0.8 5 5
FXN 0.1 0.23 -10000 0 -0.79 5 5
POU5F1 0.085 0.26 -10000 0 -0.82 8 8
neuron apoptosis -0.1 0.25 0.89 6 -10000 0 6
EP300 0.013 0 -10000 0 -10000 0 0
EGLN3 -0.041 0.21 -10000 0 -0.69 27 27
EGLN2 0.023 0.014 -10000 0 -10000 0 0
EGLN1 0.023 0.014 -10000 0 -10000 0 0
VHL/Elongin B/Elongin C -0.002 0.039 -10000 0 -0.68 1 1
VHL 0.013 0 -10000 0 -10000 0 0
ARNT 0.02 0.015 -10000 0 -10000 0 0
SLC2A1 0.09 0.25 -10000 0 -0.82 10 10
TWIST1 0.093 0.25 -10000 0 -0.98 7 7
ELK1 0.018 0.034 -10000 0 -0.58 1 1
HIF2A/ARNT/Cbp/p300 -0.036 0.089 -10000 0 -0.56 1 1
VEGFA 0.1 0.23 -10000 0 -0.8 5 5
CREBBP 0.013 0 -10000 0 -10000 0 0
Role of Calcineurin-dependent NFAT signaling in lymphocytes

Figure S109.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S109.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.011 0.034 -10000 0 -0.58 1 1
NFATC1 0.052 0.03 -10000 0 -10000 0 0
NFATC2 0.019 0.057 -10000 0 -0.33 1 1
NFATC3 0.021 0.029 -10000 0 -0.48 1 1
YWHAE 0.013 0 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/CABIN1 -0.011 0.095 -10000 0 -0.41 3 3
Exportin 1/Ran/NUP214 0 0 -10000 0 -10000 0 0
mol:DAG 0 0.002 -10000 0 -10000 0 0
CABIN1/MEF2D/CaM/Ca2+/CAMK IV -0.053 0.12 -10000 0 -0.52 10 10
BCL2/BAX -0.018 0.13 -10000 0 -0.45 24 24
CaM/Ca2+/Calcineurin A alpha-beta B1 0.01 0.005 -10000 0 -10000 0 0
CaM/Ca2+ 0.01 0.005 -10000 0 -10000 0 0
BAX 0.013 0 -10000 0 -10000 0 0
MAPK14 0.012 0.003 -10000 0 -10000 0 0
BAD 0.013 0 -10000 0 -10000 0 0
CABIN1/MEF2D -0.004 0.09 -10000 0 -0.39 3 3
Calcineurin A alpha-beta B1/BCL2 -0.037 0.17 -10000 0 -0.62 24 24
FKBP8 0.013 0 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.004 0.089 0.38 3 -10000 0 3
KPNB1 0.013 0 -10000 0 -10000 0 0
KPNA2 0.013 0 -10000 0 -10000 0 0
XPO1 0.013 0 -10000 0 -10000 0 0
SFN -0.004 0.11 -10000 0 -0.7 7 7
MAP3K8 0.008 0.054 -10000 0 -0.65 2 2
NFAT4/CK1 alpha -0.001 0.017 -10000 0 -10000 0 0
MEF2D/NFAT1/Cbp/p300 0.032 0.086 -10000 0 -10000 0 0
CABIN1 -0.011 0.096 -10000 0 -0.42 3 3
CALM1 0.012 0.003 -10000 0 -10000 0 0
RAN 0.013 0 -10000 0 -10000 0 0
MAP3K1 0.013 0 -10000 0 -10000 0 0
CAMK4 -0.037 0.18 -10000 0 -0.7 21 21
mol:Ca2+ 0 0.004 -10000 0 -10000 0 0
MAPK3 0.013 0 -10000 0 -10000 0 0
YWHAH 0.013 0 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/AKAP79/PKA 0.005 0.081 -10000 0 -0.48 8 8
YWHAB 0.013 0 -10000 0 -10000 0 0
MAPK8 0.008 0.06 -10000 0 -0.72 2 2
MAPK9 0.013 0 -10000 0 -10000 0 0
YWHAG 0.013 0 -10000 0 -10000 0 0
FKBP1A 0.013 0 -10000 0 -10000 0 0
NFAT1-c-4/YWHAQ 0.061 0.041 -10000 0 -10000 0 0
PRKCH 0.013 0 -10000 0 -10000 0 0
CABIN1/Cbp/p300 0.002 0.007 -10000 0 -10000 0 0
CASP3 0.012 0.003 -10000 0 -10000 0 0
PIM1 0.013 0 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 0.009 0.002 -10000 0 -10000 0 0
apoptosis -0.013 0.043 -10000 0 -10000 0 0
14-3-3 family/BAD/CaM/Ca2+/Calcineurin A alpha-beta B1 0.036 0.034 -10000 0 -10000 0 0
PRKCB -0.049 0.2 -10000 0 -0.68 27 27
PRKCE 0.013 0 -10000 0 -10000 0 0
JNK2/NFAT4 0.026 0.027 -10000 0 -0.43 1 1
BAD/BCL-XL 0.017 0.025 -10000 0 -0.42 1 1
PRKCD 0.013 0 -10000 0 -10000 0 0
NUP214 0.013 0 -10000 0 -10000 0 0
PRKCZ 0.01 0.042 -10000 0 -0.72 1 1
PRKCA 0.003 0.08 -10000 0 -0.69 4 4
PRKCG -0.039 0.16 -10000 0 -0.58 24 24
PRKCQ -0.037 0.18 -10000 0 -0.71 21 21
FKBP38/BCL2 -0.018 0.13 -10000 0 -0.45 24 24
EP300 0.013 0.003 -10000 0 -10000 0 0
PRKCB1 0 0 -10000 0 -10000 0 0
CSNK2A1 0.013 0 -10000 0 -10000 0 0
NFATc/JNK1 0.053 0.044 -10000 0 -10000 0 0
CaM/Ca2+/FKBP38 0.018 0.004 -10000 0 -10000 0 0
FKBP12/FK506 0.009 0 -10000 0 -10000 0 0
CSNK1A1 0.019 0.005 -10000 0 -10000 0 0
CaM/Ca2+/CAMK IV -0.015 0.12 -10000 0 -0.46 21 21
NFATc/ERK1 0.057 0.028 -10000 0 -10000 0 0
CABIN1/YWHAQ/CaM/Ca2+/CAMK IV -0.053 0.12 -10000 0 -0.52 10 10
NR4A1 0.021 0.14 -10000 0 -0.5 18 18
GSK3B 0.012 0.003 -10000 0 -10000 0 0
positive T cell selection 0.021 0.029 -10000 0 -0.48 1 1
NFAT1/CK1 alpha -0.013 0.033 -10000 0 -10000 0 0
RCH1/ KPNB1 0.019 0 -10000 0 -10000 0 0
YWHAQ 0.013 0 -10000 0 -10000 0 0
PRKACA 0.012 0.003 -10000 0 -10000 0 0
AKAP5 -0.005 0.11 -10000 0 -0.66 8 8
MEF2D 0.013 0.003 -10000 0 -10000 0 0
mol:FK506 0 0 -10000 0 -10000 0 0
YWHAZ 0.013 0 -10000 0 -10000 0 0
NFATc/p38 alpha 0.055 0.031 -10000 0 -10000 0 0
CREBBP 0.013 0.003 -10000 0 -10000 0 0
BCL2 -0.037 0.17 -10000 0 -0.62 24 24
E-cadherin signaling events

Figure S110.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S110.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
E-cadherin/beta catenin-gamma catenin -0.011 0.078 -9999 0 -0.54 6 6
E-cadherin/beta catenin 0.01 0.072 -9999 0 -0.54 5 5
CTNNB1 0.008 0.06 -9999 0 -0.72 2 2
JUP 0.008 0.06 -9999 0 -0.72 2 2
CDH1 0.005 0.073 -9999 0 -0.72 3 3
Aurora B signaling

Figure S111.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S111.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Condensin I complex 0.029 0.054 -9999 0 -0.7 1 1
STMN1 0.022 0.042 -9999 0 -0.49 2 2
Aurora B/RasGAP/Survivin 0.022 0.067 -9999 0 -0.7 2 2
Chromosomal passenger complex/Cul3 protein complex 0.024 0.063 -9999 0 -0.51 2 2
BIRC5 0.007 0.071 -9999 0 -0.7 3 3
DES -0.27 0.25 -9999 0 -0.58 111 111
Aurora C/Aurora B/INCENP 0.021 0.053 -9999 0 -0.44 3 3
Aurora B/TACC1 0.015 0.042 -9999 0 -0.48 2 2
Aurora B/PP2A 0.018 0.035 -9999 0 -0.56 1 1
mol:GTP 0 0 -9999 0 -10000 0 0
CBX5 0.015 0.023 -9999 0 -0.26 2 2
mitotic metaphase/anaphase transition -0.001 0.001 -9999 0 -10000 0 0
NDC80 0.022 0.042 -9999 0 -0.49 2 2
Cul3 protein complex -0.014 0.079 -9999 0 -0.46 9 9
KIF2C 0.019 0.065 -9999 0 -0.69 2 2
PEBP1 0.013 0.001 -9999 0 -10000 0 0
KIF20A 0.007 0.06 -9999 0 -0.73 2 2
mol:GDP 0 0 -9999 0 -10000 0 0
Aurora B/RasGAP 0.018 0.035 -9999 0 -0.56 1 1
SEPT1 -0.025 0.15 -9999 0 -0.62 18 18
SMC2 0.008 0.06 -9999 0 -0.72 2 2
SMC4 0.013 0 -9999 0 -10000 0 0
NSUN2/NPM1/Nucleolin 0.024 0.058 -9999 0 -0.96 1 1
PSMA3 0.013 0 -9999 0 -10000 0 0
G2/M transition of mitotic cell cycle -0.001 0.001 -9999 0 -10000 0 0
H3F3B 0.018 0.025 -9999 0 -0.42 1 1
AURKB 0.018 0.045 -9999 0 -0.75 1 1
AURKC 0.008 0.054 -9999 0 -0.66 2 2
CDCA8 0.011 0.044 -9999 0 -0.75 1 1
cytokinesis -0.031 0.09 -9999 0 -0.86 3 3
Aurora B/Septin1 0.007 0.12 -9999 0 -0.78 3 3
AURKA 0.007 0.06 -9999 0 -0.73 2 2
INCENP 0.012 0.043 -9999 0 -0.74 1 1
KLHL13 0.003 0.084 -9999 0 -0.72 4 4
BUB1 0.007 0.06 -9999 0 -0.73 2 2
hSgo1/Aurora B/Survivin 0.019 0.087 -9999 0 -0.72 3 3
EVI5 0.014 0.001 -9999 0 -10000 0 0
RhoA/GTP -0.008 0.076 -9999 0 -0.9 2 2
SGOL1 0.008 0.06 -9999 0 -0.72 2 2
CENPA 0.02 0.11 -9999 0 -1.3 2 2
NCAPG 0.01 0.042 -9999 0 -0.72 1 1
Aurora B/HC8 Proteasome 0.018 0.035 -9999 0 -0.56 1 1
NCAPD2 0.009 0.048 -9999 0 -0.58 2 2
Aurora B/PP1-gamma 0.018 0.035 -9999 0 -0.56 1 1
RHOA 0.013 0 -9999 0 -10000 0 0
NCAPH 0.01 0.042 -9999 0 -0.72 1 1
NPM1 0.01 0.043 -9999 0 -0.73 1 1
RASA1 0.013 0 -9999 0 -10000 0 0
KLHL9 0.001 0.094 -9999 0 -0.72 5 5
mitotic prometaphase 0.001 0.002 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.018 0.035 -9999 0 -0.56 1 1
PPP1CC 0.013 0 -9999 0 -10000 0 0
Centraspindlin -0.008 0.085 -9999 0 -1 2 2
RhoA/GDP 0.009 0 -9999 0 -10000 0 0
NSUN2 0.01 0.043 -9999 0 -0.73 1 1
MYLK 0.013 0.047 -9999 0 -0.31 6 6
KIF23 0.013 0.001 -9999 0 -10000 0 0
VIM 0.018 0.066 -9999 0 -0.55 4 4
RACGAP1 0.013 0.001 -9999 0 -10000 0 0
mitosis 0 0 -9999 0 -10000 0 0
NCL 0.01 0.043 -9999 0 -0.73 1 1
Chromosomal passenger complex 0.025 0.095 -9999 0 -0.85 3 3
Chromosomal passenger complex/EVI5 0.048 0.089 -9999 0 -0.7 3 3
TACC1 0.01 0.042 -9999 0 -0.72 1 1
PPP2R5D 0.013 0 -9999 0 -10000 0 0
CUL3 0.013 0 -9999 0 -10000 0 0
response to DNA damage stimulus 0 0 -9999 0 -10000 0 0
Canonical NF-kappaB pathway

Figure S112.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S112.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FBXW11 0.016 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.071 0.043 -9999 0 -10000 0 0
ERC1 0.013 0 -9999 0 -10000 0 0
RIP2/NOD2 0.002 0.096 -9999 0 -0.54 9 9
NFKBIA 0.044 0 -9999 0 -10000 0 0
BIRC2 -0.001 0.09 -9999 0 -0.58 7 7
IKBKB 0.013 0 -9999 0 -10000 0 0
RIPK2 0.013 0 -9999 0 -10000 0 0
IKBKG -0.012 0.05 -9999 0 -0.43 1 1
IKK complex/A20 -0.041 0.1 -9999 0 -0.56 2 2
NEMO/A20/RIP2 0.013 0 -9999 0 -10000 0 0
XPO1 0.013 0 -9999 0 -10000 0 0
NEMO/ATM 0.036 0.057 -9999 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 -9999 0 -10000 0 0
RAN 0.013 0 -9999 0 -10000 0 0
Exportin 1/RanGTP 0 0 -9999 0 -10000 0 0
IKK complex/ELKS -0.009 0.04 -9999 0 -10000 0 0
BCL10/MALT1/TRAF6 -0.001 0.02 -9999 0 -0.35 1 1
NOD2 -0.009 0.12 -9999 0 -0.72 9 9
NFKB1 0.016 0 -9999 0 -10000 0 0
RELA 0.016 0 -9999 0 -10000 0 0
MALT1 0.013 0 -9999 0 -10000 0 0
cIAP1/UbcH5C 0.009 0.066 -9999 0 -0.42 7 7
ATM 0.013 0 -9999 0 -10000 0 0
TNF/TNFR1A -0.037 0.16 -9999 0 -0.49 33 33
TRAF6 0.011 0.034 -9999 0 -0.58 1 1
PRKCA 0.003 0.08 -9999 0 -0.69 4 4
CHUK 0.013 0 -9999 0 -10000 0 0
UBE2D3 0.013 0 -9999 0 -10000 0 0
TNF -0.061 0.21 -9999 0 -0.66 33 33
NF kappa B1 p50/RelA 0 0 -9999 0 -10000 0 0
BCL10 0.013 0 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.044 0 -9999 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.016 0 -9999 0 -10000 0 0
TNFRSF1A 0.013 0 -9999 0 -10000 0 0
IKK complex 0.042 0.056 -9999 0 -10000 0 0
CYLD 0.013 0 -9999 0 -10000 0 0
IKK complex/PKC alpha -0.013 0.053 -9999 0 -10000 0 0
BARD1 signaling events

Figure S113.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S113.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BARD1/CSTF1 0.011 0.064 -10000 0 -0.54 4 4
ATM 0.013 0 -10000 0 -10000 0 0
UBE2D3 0.013 0 -10000 0 -10000 0 0
PRKDC 0.013 0 -10000 0 -10000 0 0
ATR 0.013 0 -10000 0 -10000 0 0
UBE2L3 0.013 0 -10000 0 -10000 0 0
FANCD2 0.025 0 -10000 0 -10000 0 0
protein ubiquitination -0.006 0.047 -10000 0 -10000 0 0
XRCC5 0.013 0 -10000 0 -10000 0 0
XRCC6 0.013 0 -10000 0 -10000 0 0
M/R/N Complex 0 0 -10000 0 -10000 0 0
MRE11A 0.013 0 -10000 0 -10000 0 0
DNA-PK 0 0 -10000 0 -10000 0 0
FA complex/FANCD2/Ubiquitin -0.005 0.029 -10000 0 -10000 0 0
FANCF 0.001 0.094 -10000 0 -0.72 5 5
BRCA1 0.013 0 -10000 0 -10000 0 0
CCNE1 0.011 0.034 -10000 0 -0.58 1 1
CDK2/Cyclin E1 0.017 0.025 -10000 0 -0.42 1 1
FANCG 0.011 0.034 -10000 0 -0.58 1 1
BRCA1/BACH1/BARD1 0.011 0.064 -10000 0 -0.54 4 4
FANCE 0.013 0 -10000 0 -10000 0 0
FANCC 0.013 0 -10000 0 -10000 0 0
NBN 0.013 0 -10000 0 -10000 0 0
FANCA 0.013 0 -10000 0 -10000 0 0
DNA repair 0.061 0.057 -10000 0 -10000 0 0
BRCA1/BARD1/ubiquitin 0.011 0.064 -10000 0 -0.54 4 4
BARD1/DNA-PK 0.027 0.052 -10000 0 -0.42 4 4
FANCL 0.011 0.034 -10000 0 -0.58 1 1
mRNA polyadenylation -0.011 0.064 0.54 4 -10000 0 4
BRCA1/BARD1/CTIP/M/R/N Complex 0.035 0.038 -10000 0 -10000 0 0
BRCA1/BACH1/BARD1/TopBP1 -0.006 0.053 -10000 0 -0.46 4 4
BRCA1/BARD1/P53 -0.001 0.12 -10000 0 -0.44 22 22
BARD1/CSTF1/BRCA1 -0.006 0.053 -10000 0 -0.46 4 4
BRCA1/BACH1 0.013 0 -10000 0 -10000 0 0
BARD1 0.003 0.084 -10000 0 -0.72 4 4
PCNA 0.013 0 -10000 0 -10000 0 0
BRCA1/BARD1/UbcH5C -0.006 0.053 -10000 0 -0.46 4 4
BRCA1/BARD1/UbcH7 -0.006 0.053 -10000 0 -0.46 4 4
BRCA1/BARD1/RAD51/PCNA 0.025 0.058 -10000 0 -0.42 5 5
BARD1/DNA-PK/P53 -0.03 0.11 -10000 0 -0.79 1 1
BRCA1/BARD1/Ubiquitin 0.011 0.064 -10000 0 -0.54 4 4
BRCA1/BARD1/CTIP 0.026 0.052 -10000 0 -0.42 4 4
FA complex 0.033 0.039 -10000 0 -10000 0 0
BARD1/EWS 0.01 0.072 -10000 0 -0.54 5 5
RBBP8 0.022 0 -10000 0 -10000 0 0
TP53 -0.034 0.18 -10000 0 -0.72 19 19
TOPBP1 0.013 0 -10000 0 -10000 0 0
G1/S transition of mitotic cell cycle 0.032 0.12 0.44 22 -10000 0 22
BRCA1/BARD1 -0.006 0.047 -10000 0 -10000 0 0
CSTF1 0.013 0 -10000 0 -10000 0 0
BARD1/EWS-Fli1 0.002 0.064 -10000 0 -0.55 4 4
CDK2 0.013 0 -10000 0 -10000 0 0
UniProt:Q9BZD1 0 0 -10000 0 -10000 0 0
RAD51 0.01 0.042 -10000 0 -0.72 1 1
RAD50 0.013 0 -10000 0 -10000 0 0
BRCA1/BARD1/DNA-directed RNA polymerase II holoenzyme 0.011 0.064 -10000 0 -0.54 4 4
EWSR1 0.01 0.042 -10000 0 -0.72 1 1
E-cadherin signaling in the nascent adherens junction

Figure S114.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S114.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN 0.012 0.1 -9999 0 -0.54 5 5
KLHL20 -0.016 0.05 -9999 0 -0.31 1 1
CYFIP2 -0.026 0.16 -9999 0 -0.68 17 17
Rac1/GDP 0.05 0.051 -9999 0 -10000 0 0
ENAH 0.03 0.074 -9999 0 -0.54 5 5
AP1M1 0.013 0 -9999 0 -10000 0 0
RAP1B 0.009 0.048 -9999 0 -0.58 2 2
RAP1A 0.013 0 -9999 0 -10000 0 0
CTNNB1 0.008 0.06 -9999 0 -0.72 2 2
CDC42/GTP -0.005 0.035 -9999 0 -10000 0 0
ABI1/Sra1/Nap1 -0.017 0.046 -9999 0 -0.22 6 6
E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.011 0.098 -9999 0 -0.46 11 11
RAPGEF1 0.042 0.065 -9999 0 -0.46 5 5
CTNND1 0.013 0 -9999 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion -0.01 0.072 -9999 0 -0.56 5 5
CRK 0.037 0.07 -9999 0 -0.5 5 5
E-cadherin/gamma catenin/alpha catenin -0.008 0.069 -9999 0 -0.57 4 4
alphaE/beta7 Integrin 0.003 0.091 -9999 0 -0.52 9 9
IQGAP1 0.013 0 -9999 0 -10000 0 0
NCKAP1 0.013 0 -9999 0 -10000 0 0
Rap1/GTP/I-afadin 0.021 0.029 -9999 0 -10000 0 0
DLG1 0.03 0.074 -9999 0 -0.54 5 5
ChemicalAbstracts:7440-70-2 0 0 -9999 0 -10000 0 0
mol:PI-3-4-5-P3 -0.005 0.03 -9999 0 -10000 0 0
MLLT4 0.013 0 -9999 0 -10000 0 0
ARF6/GTP/NME1/Tiam1 0.019 0.049 -9999 0 -0.43 3 3
PI3K -0.006 0.039 -9999 0 -10000 0 0
ARF6 0.013 0 -9999 0 -10000 0 0
mol:Ca2+ 0 0 -9999 0 -10000 0 0
E-cadherin/gamma catenin 0.009 0.08 -9999 0 -0.66 4 4
TIAM1 0.005 0.073 -9999 0 -0.72 3 3
E-cadherin(dimer)/Ca2+ -0.007 0.051 -9999 0 -0.4 5 5
AKT1 -0.003 0.022 -9999 0 -10000 0 0
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
CDH1 0.005 0.073 -9999 0 -0.72 3 3
RhoA/GDP 0.05 0.05 -9999 0 -10000 0 0
actin cytoskeleton organization 0.029 0.05 -9999 0 -0.22 1 1
CDC42/GDP 0.05 0.05 -9999 0 -10000 0 0
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.019 0.05 -9999 0 -0.39 4 4
ITGB7 -0.004 0.11 -9999 0 -0.72 7 7
RAC1 0.013 0 -9999 0 -10000 0 0
E-cadherin/beta catenin/alpha catenin/p120 catenin 0.024 0.058 -9999 0 -0.42 5 5
E-cadherin/Ca2+/beta catenin/alpha catenin -0.007 0.052 -9999 0 -0.4 5 5
mol:GDP 0.047 0.058 -9999 0 -10000 0 0
CDC42/GTP/IQGAP1 0 0 -9999 0 -10000 0 0
JUP 0.008 0.06 -9999 0 -0.72 2 2
p120 catenin/RhoA/GDP -0.006 0.042 -9999 0 -10000 0 0
RAC1/GTP/IQGAP1 0 0 -9999 0 -10000 0 0
PIP5K1C/AP1M1 0.019 0 -9999 0 -10000 0 0
RHOA 0.013 0 -9999 0 -10000 0 0
CDC42 0.013 0 -9999 0 -10000 0 0
CTNNA1 0.013 0 -9999 0 -10000 0 0
positive regulation of S phase of mitotic cell cycle 0.016 0.065 -9999 0 -0.22 19 19
NME1 0.011 0.034 -9999 0 -0.58 1 1
clathrin coat assembly 0 0 -9999 0 -10000 0 0
TJP1 0.03 0.074 -9999 0 -0.54 5 5
regulation of cell-cell adhesion -0.005 0.031 -9999 0 -10000 0 0
WASF2 -0.009 0.024 -9999 0 -10000 0 0
Rap1/GTP -0.006 0.041 -9999 0 -10000 0 0
E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.017 0.1 -9999 0 -0.93 2 2
CCND1 0.017 0.081 -9999 0 -0.28 19 19
VAV2 0.034 0.095 -9999 0 -0.63 4 4
RAP1/GDP 0.046 0.05 -9999 0 -10000 0 0
adherens junction assembly 0.03 0.072 -9999 0 -0.52 5 5
homophilic cell adhesion 0 0 -9999 0 -10000 0 0
ABI1 0.013 0 -9999 0 -10000 0 0
PIP5K1C 0.013 0 -9999 0 -10000 0 0
regulation of heterotypic cell-cell adhesion 0.021 0.11 -9999 0 -0.89 2 2
E-cadherin/beta catenin -0.005 0.046 -9999 0 -0.46 3 3
mol:GTP 0 0 -9999 0 -10000 0 0
SRC 0.029 0.075 -9999 0 -0.54 5 5
PIK3CA 0.013 0 -9999 0 -10000 0 0
Rac1/GTP -0.025 0.081 -9999 0 -0.47 2 2
E-cadherin/beta catenin/alpha catenin -0.008 0.059 -9999 0 -0.46 5 5
ITGAE 0.009 0.048 -9999 0 -0.58 2 2
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.01 0.074 -9999 0 -0.58 5 5
Arf6 trafficking events

Figure S115.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S115.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SLC2A4 -0.064 0.21 -10000 0 -0.62 37 37
CLTC 0.03 0.014 -10000 0 -10000 0 0
calcium ion-dependent exocytosis 0.024 0.02 -10000 0 -10000 0 0
Dynamin 2/GTP 0.022 0.02 -10000 0 -10000 0 0
EXOC4 0.013 0 -10000 0 -10000 0 0
CD59 0.026 0.019 -10000 0 -10000 0 0
CPE 0.001 0.088 -10000 0 -0.43 12 12
CTNNB1 0.008 0.06 -10000 0 -0.72 2 2
membrane fusion 0.023 0.021 -10000 0 -10000 0 0
CTNND1 0.03 0.019 -10000 0 -10000 0 0
DNM2 0.013 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 0.03 0.012 -10000 0 -10000 0 0
TSHR -0.023 0.12 -10000 0 -0.39 29 29
INS 0.011 0.004 -10000 0 -10000 0 0
BIN1 -0.021 0.15 -10000 0 -0.67 15 15
mol:Choline 0.023 0.021 -10000 0 -10000 0 0
growth hormone secretagogue receptor activity 0 0 -10000 0 -10000 0 0
mol:GDP 0.017 0.022 -10000 0 -0.36 1 1
membrane depolarization 0 0 -10000 0 -10000 0 0
ARF6 0.013 0 -10000 0 -10000 0 0
mol:Ca2+ 0.022 0.02 -10000 0 -10000 0 0
JUP 0.025 0.033 -10000 0 -0.46 1 1
ASAP2/amphiphysin II 0.004 0.09 -10000 0 -0.43 9 9
ARF6/GTP 0.009 0 -10000 0 -10000 0 0
CDH1 0.024 0.03 -10000 0 -10000 0 0
clathrin-independent pinocytosis 0.009 0 -10000 0 -10000 0 0
MAPK8IP3 0.013 0 -10000 0 -10000 0 0
positive regulation of endocytosis 0.009 0 -10000 0 -10000 0 0
EXOC2 0.013 0 -10000 0 -10000 0 0
substrate adhesion-dependent cell spreading 0.042 0 -10000 0 -10000 0 0
insulin receptor binding 0 0 -10000 0 -10000 0 0
SPAG9 0.013 0 -10000 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion 0.005 0.035 -10000 0 -10000 0 0
positive regulation of phagocytosis 0.018 0 -10000 0 -10000 0 0
ARF6/GTP/JIP3 0 0 -10000 0 -10000 0 0
ACAP1 0.021 0.022 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CHRM2 0.021 0.012 -10000 0 -10000 0 0
clathrin heavy chain/ACAP1 0.034 0.017 -10000 0 -10000 0 0
JIP4/KLC1 0.025 0 -10000 0 -10000 0 0
EXOC1 0.013 0 -10000 0 -10000 0 0
exocyst 0.042 0 -10000 0 -10000 0 0
RALA/GTP 0.009 0 -10000 0 -10000 0 0
ARF6/GTP/ARF6/GTP/JIP4/Dynactin Complex 0 0 -10000 0 -10000 0 0
receptor recycling 0.009 0 -10000 0 -10000 0 0
CTNNA1 0.03 0.019 -10000 0 -10000 0 0
NME1 0.017 0.022 -10000 0 -0.36 1 1
clathrin coat assembly 0.03 0.014 -10000 0 -10000 0 0
IL2RA 0.013 0.061 -10000 0 -0.35 1 1
VAMP3 0.018 0 -10000 0 -10000 0 0
GLUT4/clathrin heavy chain/ACAP1 -0.035 0.091 -10000 0 -10000 0 0
EXOC6 0.013 0 -10000 0 -10000 0 0
PLD1 0.018 0.034 -10000 0 -0.32 3 3
PLD2 0.022 0 -10000 0 -10000 0 0
EXOC5 0.013 0 -10000 0 -10000 0 0
PIP5K1C 0.03 0.012 -10000 0 -10000 0 0
SDC1 0.026 0.016 -10000 0 -10000 0 0
ARF6/GDP 0.016 0.022 -10000 0 -0.36 1 1
EXOC7 0.013 0 -10000 0 -10000 0 0
E-cadherin/beta catenin -0.005 0.036 -10000 0 -10000 0 0
mol:Phosphatidic acid 0.023 0.021 -10000 0 -10000 0 0
endocytosis 0.019 0.084 0.42 9 -10000 0 9
SCAMP2 0.013 0 -10000 0 -10000 0 0
ADRB2 -0.001 0.12 -10000 0 -0.38 26 26
EXOC3 0.013 0 -10000 0 -10000 0 0
ASAP2 0.013 0 -10000 0 -10000 0 0
Dynamin 2/GDP 0.023 0.02 -10000 0 -10000 0 0
KLC1 0.013 0 -10000 0 -10000 0 0
AVPR2 0.012 0.094 -10000 0 -0.37 15 15
RALA 0.013 0 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.004 0.033 -10000 0 -10000 0 0
VEGFR1 specific signals

Figure S116.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S116.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR1 homodimer/VEGFB homodimer 0.026 0.071 -9999 0 -0.85 2 2
VEGFR1 homodimer/NRP1 0.016 0.071 -9999 0 -0.86 2 2
mol:DAG 0.017 0.1 -9999 0 -0.78 2 2
VEGFR1 homodimer/NRP1/VEGFR 121 -0.006 0.067 -9999 0 -0.8 2 2
CaM/Ca2+ 0.023 0.097 -9999 0 -0.74 2 2
HIF1A 0.018 0.032 -9999 0 -0.37 2 2
GAB1 0.013 0 -9999 0 -10000 0 0
AKT1 0.035 0.097 -9999 0 -0.68 2 2
PLCG1 0.017 0.1 -9999 0 -0.78 2 2
NOS3 0.036 0.11 -9999 0 -0.86 2 2
CBL 0.013 0 -9999 0 -10000 0 0
mol:NO 0.036 0.1 -9999 0 -0.8 2 2
FLT1 0.023 0.08 -9999 0 -0.95 2 2
PGF -0.014 0.13 -9999 0 -0.67 12 12
VEGFR1 homodimer/NRP2/VEGFR121 0.024 0.099 -9999 0 -0.98 2 2
CALM1 0.013 0 -9999 0 -10000 0 0
PIK3CA 0.013 0 -9999 0 -10000 0 0
eNOS/Hsp90 0.042 0.1 -9999 0 -0.76 2 2
endothelial cell proliferation 0.002 0.14 -9999 0 -0.84 3 3
mol:Ca2+ 0.017 0.1 -9999 0 -0.77 2 2
MAPK3 0.025 0.11 -9999 0 -0.85 2 2
MAPK1 0.025 0.11 -9999 0 -0.85 2 2
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
PLGF homodimer -0.014 0.13 -9999 0 -0.66 12 12
PRKACA 0.013 0 -9999 0 -10000 0 0
RP11-342D11.1 0 0 -9999 0 -10000 0 0
CAV1 -0.049 0.2 -9999 0 -0.71 26 26
VEGFA homodimer 0.011 0.034 -9999 0 -0.58 1 1
VEGFR1 homodimer/VEGFA homodimer 0.025 0.074 -9999 0 -0.85 2 2
platelet activating factor biosynthetic process 0.031 0.1 -9999 0 -0.82 2 2
PI3K 0.021 0.1 -9999 0 -0.74 2 2
PRKCA 0.019 0.11 -9999 0 -0.91 2 2
PRKCB -0.011 0.15 -9999 0 -0.74 3 3
VEGFR1 homodimer/PLGF homodimer 0.008 0.11 -9999 0 -0.85 2 2
VEGFA 0.011 0.034 -9999 0 -0.58 1 1
VEGFB 0.013 0 -9999 0 -10000 0 0
mol:IP3 0.017 0.1 -9999 0 -0.78 2 2
RASA1 0.033 0.067 -9999 0 -0.78 2 2
NRP2 0.001 0.091 -9999 0 -0.7 5 5
VEGFR1 homodimer 0.023 0.079 -9999 0 -0.95 2 2
VEGFB homodimer 0.013 0 -9999 0 -10000 0 0
NCK1 0.013 0 -9999 0 -10000 0 0
eNOS/Caveolin-1 0.01 0.15 -9999 0 -0.7 4 4
PTPN11 0.013 0 -9999 0 -10000 0 0
mol:PI-3-4-5-P3 -0.02 0.092 -9999 0 -0.73 2 2
mol:L-citrulline 0.036 0.1 -9999 0 -0.8 2 2
VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP 0.038 0.067 -9999 0 -0.75 2 2
VEGFR1 homodimer/VEGFA homodimer/NCK1 0.031 0.07 -9999 0 -0.79 2 2
CD2AP 0.013 0 -9999 0 -10000 0 0
PI3K/GAB1 -0.019 0.088 -9999 0 -0.7 2 2
PDPK1 0.027 0.096 -9999 0 -0.69 2 2
VEGFR1 homodimer/VEGFA homodimer/SHP2 0.031 0.07 -9999 0 -0.79 2 2
mol:NADP 0.036 0.1 -9999 0 -0.8 2 2
HSP90AA1 0.013 0 -9999 0 -10000 0 0
ubiquitin-dependent protein catabolic process -0.006 0.062 -9999 0 -0.74 2 2
VEGFR1 homodimer/NRP2 0.018 0.1 -9999 0 -1 2 2
E-cadherin signaling in keratinocytes

Figure S117.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S117.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
keratinocyte differentiation 0.041 0.051 -10000 0 -0.43 2 2
adherens junction organization 0.028 0.078 -10000 0 -0.52 4 4
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP 0.032 0.088 -10000 0 -0.77 1 1
FMN1 0.017 0.11 -10000 0 -0.62 4 4
mol:IP3 0.034 0.051 -10000 0 -0.45 2 2
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.028 0.066 -10000 0 -0.61 2 2
CTNNB1 0.008 0.06 -10000 0 -0.72 2 2
AKT1 0.04 0.054 -10000 0 -0.48 2 2
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.03 0.079 -10000 0 -0.55 5 5
CTNND1 0.014 0.001 -10000 0 -10000 0 0
mol:PI-4-5-P2 0.034 0.061 -10000 0 -0.56 2 2
VASP 0.034 0.063 -10000 0 -0.57 2 2
ZYX 0.034 0.063 -10000 0 -0.57 2 2
JUB 0.028 0.09 -10000 0 -0.75 2 2
EGFR(dimer) 0.017 0.1 -10000 0 -0.75 2 2
E-cadherin/beta catenin-gamma catenin -0.01 0.075 -10000 0 -0.52 6 6
mol:PI-3-4-5-P3 -0.007 0.051 -10000 0 -0.46 3 3
PIK3CA 0.013 0.001 -10000 0 -10000 0 0
PI3K 0.033 0.058 -10000 0 -0.52 2 2
FYN 0.035 0.071 -10000 0 -0.57 1 1
mol:Ca2+ 0.034 0.049 -10000 0 -0.44 2 2
JUP 0.008 0.059 -10000 0 -0.72 2 2
PIK3R1 0.009 0.055 -10000 0 -0.66 2 2
mol:DAG 0.034 0.051 -10000 0 -0.45 2 2
CDH1 0.005 0.073 -10000 0 -0.72 3 3
RhoA/GDP 0.032 0.088 -10000 0 -0.77 1 1
establishment of polarity of embryonic epithelium 0.034 0.061 -10000 0 -0.56 2 2
SRC 0.013 0 -10000 0 -10000 0 0
RAC1 0.013 0 -10000 0 -10000 0 0
RHOA 0.013 0 -10000 0 -10000 0 0
EGFR -0.019 0.14 -10000 0 -0.63 15 15
CASR 0.03 0.066 -10000 0 -0.45 1 1
RhoA/GTP -0.005 0.04 -10000 0 -0.4 2 2
AKT2 0.04 0.054 -10000 0 -0.48 2 2
actin cable formation 0.023 0.11 -10000 0 -0.59 4 4
apoptosis -0.038 0.053 0.43 3 -10000 0 3
CTNNA1 0.014 0.001 -10000 0 -10000 0 0
mol:GDP 0.025 0.094 -10000 0 -0.64 2 2
PIP5K1A 0.034 0.063 -10000 0 -0.57 2 2
PLCG1 0.034 0.052 -10000 0 -0.46 2 2
Rac1/GTP -0.02 0.084 -10000 0 -0.66 2 2
homophilic cell adhesion 0.001 0.001 -10000 0 -10000 0 0
PLK2 and PLK4 events

Figure S118.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S118.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLK2 0.008 0.06 -9999 0 -0.72 2 2
PLK4 0.013 0 -9999 0 -10000 0 0
regulation of centriole replication 0.018 0.046 -9999 0 -0.54 2 2
Arf6 downstream pathway

Figure S119.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S119.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLAUR 0.035 0.079 -10000 0 -1.2 1 1
regulation of axonogenesis -0.024 0.034 0.29 3 -10000 0 3
myoblast fusion -0.014 0.035 0.42 1 -10000 0 1
mol:GTP -0.002 0.018 -10000 0 -0.24 1 1
regulation of calcium-dependent cell-cell adhesion -0.027 0.055 0.45 3 -10000 0 3
ARF1/GTP -0.001 0.012 -10000 0 -10000 0 0
mol:GM1 0.009 0.014 -10000 0 -10000 0 0
mol:Choline 0.022 0.05 -10000 0 -0.47 3 3
lamellipodium assembly -0.004 0.037 -10000 0 -0.46 1 1
MAPK3 0.026 0.026 -10000 0 -0.35 1 1
ARF6/GTP/NME1/Tiam1 0.027 0.055 -10000 0 -0.45 3 3
ARF1 0.013 0 -10000 0 -10000 0 0
ARF6/GDP 0.014 0.035 -10000 0 -0.42 1 1
ARF1/GDP 0.023 0.033 -10000 0 -0.39 1 1
ARF6 0.011 0.01 -10000 0 -10000 0 0
RAB11A 0.013 0 -10000 0 -10000 0 0
TIAM1 0.007 0.073 -10000 0 -0.72 3 3
fibronectin binding 0 0 -10000 0 -10000 0 0
MAPK1 0.026 0.026 -10000 0 -0.35 1 1
actin filament bundle formation -0.021 0.032 0.38 1 -10000 0 1
KALRN -0.01 0.062 -10000 0 -0.37 8 8
RAB11FIP3/RAB11A 0.019 0 -10000 0 -10000 0 0
RhoA/GDP 0.021 0.033 -10000 0 -0.39 1 1
NME1 0.012 0.034 -10000 0 -0.58 1 1
Rac1/GDP 0.021 0.033 -10000 0 -0.39 1 1
substrate adhesion-dependent cell spreading -0.002 0.018 -10000 0 -0.24 1 1
cortical actin cytoskeleton organization -0.004 0.037 -10000 0 -0.46 1 1
RAC1 0.013 0 -10000 0 -10000 0 0
liver development -0.002 0.018 -10000 0 -0.24 1 1
ARF6/GTP -0.002 0.018 -10000 0 -0.24 1 1
RhoA/GTP -0.001 0.012 -10000 0 -10000 0 0
mol:GDP -0.004 0.034 -10000 0 -0.43 1 1
ARF6/GTP/RAB11FIP3/RAB11A -0.001 0.009 -10000 0 -10000 0 0
RHOA 0.013 0 -10000 0 -10000 0 0
PLD1 0.014 0.056 -10000 0 -0.53 3 3
RAB11FIP3 0.013 0 -10000 0 -10000 0 0
tube morphogenesis -0.004 0.037 -10000 0 -0.46 1 1
ruffle organization 0.024 0.034 -10000 0 -0.29 3 3
regulation of epithelial cell migration -0.002 0.018 -10000 0 -0.24 1 1
PLD2 0.019 0.014 -10000 0 -10000 0 0
PIP5K1A 0.024 0.034 -10000 0 -0.29 3 3
mol:Phosphatidic acid 0.022 0.05 -10000 0 -0.47 3 3
Rac1/GTP -0.004 0.037 -10000 0 -0.46 1 1
Aurora C signaling

Figure S120.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S120.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
INCENP 0.01 0.042 -9999 0 -0.72 1 1
Aurora C/Aurora B/INCENP 0.019 0.049 -9999 0 -0.43 3 3
metaphase 0 0 -9999 0 -10000 0 0
mitosis 0 0 -9999 0 -10000 0 0
H3F3B -0.002 0.013 -9999 0 -10000 0 0
AURKB 0.01 0.042 -9999 0 -0.72 1 1
AURKC 0.008 0.054 -9999 0 -0.66 2 2
mTOR signaling pathway

Figure S121.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S121.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GBL 0 0 -10000 0 -10000 0 0
MKNK1 0.013 0 -10000 0 -10000 0 0
mol:PIP3 -0.01 0.062 0.31 1 -0.33 9 10
FRAP1 0.013 0.016 -10000 0 -10000 0 0
AKT1 0.018 0.055 0.24 1 -0.36 1 2
INSR 0.01 0.042 -10000 0 -0.72 1 1
Insulin Receptor/Insulin -0.002 0.028 -10000 0 -0.48 1 1
mol:GTP -0.007 0.038 -10000 0 -10000 0 0
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA/eIF3/40s Ribosomal subunit -0.002 0.012 -10000 0 -10000 0 0
TSC2 0.013 0 -10000 0 -10000 0 0
RHEB/GDP -0.006 0.032 -10000 0 -10000 0 0
TSC1 0.013 0 -10000 0 -10000 0 0
Insulin Receptor/IRS1 0.004 0.071 -10000 0 -0.4 9 9
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA -0.003 0.014 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
EIF3A 0.013 0 -10000 0 -10000 0 0
RPS6KB1 0.022 0.032 -10000 0 -10000 0 0
MAP3K5 0.009 0.025 -10000 0 -0.43 1 1
PIK3R1 0.008 0.054 -10000 0 -0.65 2 2
apoptosis 0.009 0.025 -10000 0 -0.43 1 1
mol:LY294002 0 0 -10000 0 -0.002 8 8
EIF4B 0.028 0.029 -10000 0 -10000 0 0
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 -0.004 0.024 -10000 0 -10000 0 0
eIF4E/eIF4G1/eIF4A1 -0.001 0.005 -10000 0 -10000 0 0
KIAA1303 0 0 -10000 0 -10000 0 0
PI3K 0.012 0.068 -10000 0 -0.35 10 10
mTOR/RHEB/GTP/Raptor/GBL 0.027 0.023 0.17 1 -10000 0 1
FKBP1A 0.013 0 -10000 0 -10000 0 0
RHEB/GTP -0.006 0.032 -10000 0 -10000 0 0
mol:Amino Acids 0 0 -10000 0 -0.002 8 8
FKBP12/Rapamycin 0.01 0.002 -10000 0 -10000 0 0
PDPK1 -0.009 0.055 0.25 1 -0.36 1 2
EIF4E 0.013 0 -10000 0 -10000 0 0
ASK1/PP5C 0.018 0.038 -10000 0 -0.62 1 1
mTOR/RHEB/GTP/Raptor/GBL/eIF4E 0.017 0.001 -10000 0 -10000 0 0
TSC1/TSC2 0.03 0.047 -10000 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 0.002 8 -10000 0 8
RPS6 0.011 0.034 -10000 0 -0.58 1 1
PPP5C 0.013 0 -10000 0 -10000 0 0
EIF4G1 0.013 0 -10000 0 -10000 0 0
IRS1 -0.003 0.07 -10000 0 -0.43 8 8
INS 0 0 -10000 0 -10000 0 0
PTEN 0.01 0.042 -10000 0 -0.72 1 1
PDK2 -0.009 0.055 0.25 1 -0.36 1 2
EIF4EBP1 0.009 0.028 -10000 0 -10000 0 0
PIK3CA 0.013 0 -10000 0 -10000 0 0
PPP2R5D 0.019 0.015 -10000 0 -10000 0 0
peptide biosynthetic process 0.015 0.026 -10000 0 -0.43 1 1
RHEB 0.013 0 -10000 0 -10000 0 0
EIF4A1 0.013 0 -10000 0 -10000 0 0
mol:Rapamycin 0 0 0.004 1 -10000 0 1
EEF2 0.015 0.026 -10000 0 -0.43 1 1
eIF4E/4E-BP1 0.016 0.024 -10000 0 -10000 0 0
Signaling events mediated by HDAC Class I

Figure S122.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S122.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NF kappa B/RelA -0.039 0.12 -9999 0 -0.44 19 19
Ran/GTP/Exportin 1/HDAC1 0 0 -9999 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.009 0.11 -9999 0 -10000 0 0
SUMO1 0.013 0 -9999 0 -10000 0 0
ZFPM1 0.01 0.042 -9999 0 -0.72 1 1
NPC/RanGAP1/SUMO1/Ubc9 0.021 0 -9999 0 -10000 0 0
FKBP3 0.013 0 -9999 0 -10000 0 0
Histones 0.022 0.063 -9999 0 -10000 0 0
YY1/LSF 0.024 0.049 -9999 0 -0.45 2 2
SMG5 0.013 0 -9999 0 -10000 0 0
RAN 0.013 0 -9999 0 -10000 0 0
I kappa B alpha/HDAC3 0 0.098 -9999 0 -10000 0 0
I kappa B alpha/HDAC1 0.008 0.07 -9999 0 -10000 0 0
SAP18 0.013 0 -9999 0 -10000 0 0
RELA 0.007 0.088 -9999 0 -10000 0 0
HDAC1/Smad7 0 0 -9999 0 -10000 0 0
RANGAP1 0.013 0 -9999 0 -10000 0 0
HDAC3/TR2 0.008 0.07 -9999 0 -10000 0 0
NuRD/MBD3 Complex 0.046 0 -9999 0 -10000 0 0
NF kappa B1 p50/RelA 0.012 0.081 -9999 0 -10000 0 0
EntrezGene:23225 0 0 -9999 0 -10000 0 0
GATA2 0.003 0.084 -9999 0 -0.72 4 4
GATA1 0.003 0.068 -9999 0 -0.58 4 4
Mad/Max 0.019 0 -9999 0 -10000 0 0
NuRD/MBD3 Complex/GATA1/Fog1 0.053 0.023 -9999 0 -10000 0 0
RBBP7 0.013 0 -9999 0 -10000 0 0
NPC 0 0 -9999 0 -10000 0 0
RBBP4 0.013 0 -9999 0 -10000 0 0
MAX 0.013 0 -9999 0 -10000 0 0
EntrezGene:9972 0 0 -9999 0 -10000 0 0
FBXW11 0.013 0 -9999 0 -10000 0 0
NFKBIA 0.001 0.078 -9999 0 -10000 0 0
KAT2B 0.005 0.073 -9999 0 -0.72 3 3
mol:GTP 0 0 -9999 0 -10000 0 0
SIN3/HDAC complex 0.042 0 -9999 0 -10000 0 0
SIN3 complex 0.033 0 -9999 0 -10000 0 0
SMURF1 0.013 0 -9999 0 -10000 0 0
CHD3 0.013 0 -9999 0 -10000 0 0
SAP30 0.013 0 -9999 0 -10000 0 0
EntrezGene:23636 0 0 -9999 0 -10000 0 0
NCOR1 0.013 0 -9999 0 -10000 0 0
YY1/HDAC3 0.018 0.07 -9999 0 -10000 0 0
YY1/HDAC2 0.027 0.031 -9999 0 -10000 0 0
YY1/HDAC1 0.027 0.031 -9999 0 -10000 0 0
NuRD/MBD2 Complex (MeCP1) 0.046 0 -9999 0 -10000 0 0
PPARG -0.077 0.16 -9999 0 -0.52 19 19
HDAC8/hEST1B 0 0 -9999 0 -10000 0 0
UBE2I 0.013 0 -9999 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.013 0 -9999 0 -10000 0 0
TNFRSF1A 0.013 0 -9999 0 -10000 0 0
HDAC3/SMRT (N-CoR2) 0.008 0.07 -9999 0 -10000 0 0
MBD3L2 0 0 -9999 0 -10000 0 0
ubiquitin-dependent protein catabolic process 0 0 -9999 0 -10000 0 0
CREBBP 0.013 0 -9999 0 -10000 0 0
NuRD/MBD3/MBD3L2 Complex 0.049 0 -9999 0 -10000 0 0
HDAC1 0.013 0 -9999 0 -10000 0 0
HDAC3 0.001 0.078 -9999 0 -10000 0 0
HDAC2 0.013 0 -9999 0 -10000 0 0
YY1 0.026 0.036 -9999 0 -0.33 3 3
HDAC8 0.013 0 -9999 0 -10000 0 0
SMAD7 0.013 0 -9999 0 -10000 0 0
NCOR2 0.013 0 -9999 0 -10000 0 0
MXD1 0.013 0 -9999 0 -10000 0 0
STAT3 0.025 0 -9999 0 -10000 0 0
NFKB1 0.013 0 -9999 0 -10000 0 0
EntrezGene:8021 0 0 -9999 0 -10000 0 0
RANBP2 0.013 0 -9999 0 -10000 0 0
YY1/LSF/HDAC1 0.03 0.045 -9999 0 -0.41 2 2
YY1/SAP30/HDAC1 0.033 0.028 -9999 0 -10000 0 0
EP300 0.013 0 -9999 0 -10000 0 0
STAT3 (dimer non-phopshorylated) 0.025 0 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.001 0.078 -9999 0 -10000 0 0
histone deacetylation 0.046 0 -9999 0 -10000 0 0
STAT3 (dimer non-phopshorylated)/HDAC3 0.018 0.065 -9999 0 -10000 0 0
nuclear export 0 0 -9999 0 -10000 0 0
PRKACA 0.013 0 -9999 0 -10000 0 0
GATAD2B 0.013 0 -9999 0 -10000 0 0
GATAD2A 0.013 0 -9999 0 -10000 0 0
GATA2/HDAC3 0.002 0.085 -9999 0 -0.42 4 4
GATA1/HDAC1 0.012 0.05 -9999 0 -0.42 4 4
GATA1/HDAC3 -0.001 0.081 -9999 0 -0.47 1 1
CHD4 0.013 0 -9999 0 -10000 0 0
TNF-alpha/TNFR1A -0.037 0.16 -9999 0 -0.49 33 33
SIN3/HDAC complex/Mad/Max 0.046 0 -9999 0 -10000 0 0
NuRD Complex 0.054 0 -9999 0 -10000 0 0
positive regulation of chromatin silencing -0.017 0.049 -9999 0 -10000 0 0
SIN3B 0.013 0 -9999 0 -10000 0 0
MTA2 0.013 0 -9999 0 -10000 0 0
SIN3A 0.013 0 -9999 0 -10000 0 0
XPO1 0.013 0 -9999 0 -10000 0 0
SUMO1/HDAC1 0.03 0 -9999 0 -10000 0 0
HDAC complex 0.033 0 -9999 0 -10000 0 0
GATA1/Fog1 0.01 0.06 -9999 0 -0.45 5 5
FKBP25/HDAC1/HDAC2 0 0 -9999 0 -10000 0 0
TNF -0.061 0.21 -9999 0 -0.66 33 33
negative regulation of cell growth 0.046 0 -9999 0 -10000 0 0
NuRD/MBD2/PRMT5 Complex 0.046 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1 0.032 0 -9999 0 -10000 0 0
NF kappa B/RelA/I kappa B alpha 0.002 0.12 -9999 0 -0.4 19 19
SIN3/HDAC complex/NCoR1 0.044 0 -9999 0 -10000 0 0
TFCP2 0.008 0.06 -9999 0 -0.72 2 2
NR2C1 0.013 0 -9999 0 -10000 0 0
MBD3 0.013 0 -9999 0 -10000 0 0
MBD2 0.013 0 -9999 0 -10000 0 0
FoxO family signaling

Figure S123.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S123.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G6PC 0.029 0.021 -9999 0 -0.32 1 1
PLK1 0.061 0.14 -9999 0 -10000 0 0
CDKN1B 0.13 0.054 -9999 0 -10000 0 0
FOXO3 0.057 0.15 -9999 0 -0.64 3 3
KAT2B 0.013 0.074 -9999 0 -0.71 3 3
FOXO1/SIRT1 0.016 0.034 -9999 0 -10000 0 0
CAT 0.051 0.2 -9999 0 -1.4 3 3
CTNNB1 0.008 0.06 -9999 0 -0.72 2 2
AKT1 0.022 0.014 -9999 0 -10000 0 0
FOXO1 0.032 0.023 -9999 0 -0.35 1 1
MAPK10 -0.023 0.14 -9999 0 -0.39 29 29
mol:GTP 0.002 0 -9999 0 -10000 0 0
FOXO4 0.07 0.074 -9999 0 -10000 0 0
response to oxidative stress 0.009 0.017 -9999 0 -10000 0 0
FOXO3A/SIRT1 0.009 0.093 -9999 0 -10000 0 0
XPO1 0.013 0 -9999 0 -10000 0 0
EP300 0.014 0 -9999 0 -10000 0 0
BCL2L11 0.027 0.036 -9999 0 -10000 0 0
FOXO1/SKP2 0.035 0.021 -9999 0 -10000 0 0
mol:GDP 0.009 0.017 -9999 0 -10000 0 0
RAN 0.014 0 -9999 0 -10000 0 0
GADD45A 0.1 0.062 -9999 0 -0.48 1 1
YWHAQ 0.013 0 -9999 0 -10000 0 0
FOXO1/14-3-3 family 0.068 0.03 -9999 0 -10000 0 0
MST1 -0.001 0.12 -9999 0 -0.63 10 10
CSNK1D 0.013 0 -9999 0 -10000 0 0
CSNK1E 0.013 0 -9999 0 -10000 0 0
FOXO4/14-3-3 family 0.048 0.05 -9999 0 -10000 0 0
YWHAB 0.013 0 -9999 0 -10000 0 0
MAPK8 0.035 0.036 -9999 0 -0.4 2 2
MAPK9 0.038 0.007 -9999 0 -10000 0 0
YWHAG 0.013 0 -9999 0 -10000 0 0
YWHAE 0.013 0 -9999 0 -10000 0 0
YWHAZ 0.013 0 -9999 0 -10000 0 0
SIRT1 0.013 0.026 -9999 0 -10000 0 0
SOD2 0.12 0.076 -9999 0 -10000 0 0
RBL2 0.074 0.11 -9999 0 -10000 0 0
RAL/GDP 0.028 0.013 -9999 0 -10000 0 0
CHUK 0.02 0.013 -9999 0 -10000 0 0
Ran/GTP 0.014 0.001 -9999 0 -10000 0 0
CSNK1G2 0.013 0 -9999 0 -10000 0 0
RAL/GTP 0.036 0.011 -9999 0 -10000 0 0
CSNK1G1 0.013 0 -9999 0 -10000 0 0
FASLG -0.2 0.54 -9999 0 -1.5 40 40
SKP2 0.013 0 -9999 0 -10000 0 0
USP7 0.014 0 -9999 0 -10000 0 0
IKBKB 0.02 0.013 -9999 0 -10000 0 0
CCNB1 0.058 0.16 -9999 0 -1.3 1 1
FOXO1-3a-4/beta catenin 0.11 0.11 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.035 0.021 -9999 0 -10000 0 0
CSNK1A1 0.013 0 -9999 0 -10000 0 0
SGK1 0.016 0.057 -9999 0 -0.66 2 2
CSNK1G3 0.013 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1 0.024 0.001 -9999 0 -10000 0 0
ZFAND5 0.073 0.066 -9999 0 -10000 0 0
SFN -0.004 0.11 -9999 0 -0.7 7 7
CDK2 0.012 0.001 -9999 0 -10000 0 0
FOXO3A/14-3-3 0.055 0.05 -9999 0 -10000 0 0
CREBBP 0.012 0.001 -9999 0 -10000 0 0
FBXO32 0.052 0.18 -9999 0 -1.4 2 2
BCL6 0.074 0.11 -9999 0 -10000 0 0
RALB 0.014 0 -9999 0 -10000 0 0
RALA 0.014 0 -9999 0 -10000 0 0
YWHAH 0.013 0 -9999 0 -10000 0 0
Atypical NF-kappaB pathway

Figure S124.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S124.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL3/RelA 0.019 0 -9999 0 -10000 0 0
FBXW11 0.013 0 -9999 0 -10000 0 0
NF kappa B1 p50/c-Rel 0.016 0.068 -9999 0 -0.46 6 6
NF kappa B1 p50/RelA/I kappa B alpha 0.032 0.059 -9999 0 -0.41 1 1
NFKBIA 0.012 0.066 -9999 0 -0.48 1 1
MAPK14 0.013 0 -9999 0 -10000 0 0
NF kappa B1 p105/p50 0.026 0 -9999 0 -10000 0 0
ARRB2 0.017 0 -9999 0 -10000 0 0
REL -0.002 0.1 -9999 0 -0.72 6 6
response to oxidative stress 0 0 -9999 0 -10000 0 0
BCL3/NF kappa B1 p50 0.026 0 -9999 0 -10000 0 0
response to UV 0 0 -9999 0 -10000 0 0
NF kappa B1 p105/RelA 0.026 0 -9999 0 -10000 0 0
PIK3CA 0.013 0 -9999 0 -10000 0 0
NF kappa B1 p50 dimer 0.02 0 -9999 0 -10000 0 0
PIK3R1 0.008 0.054 -9999 0 -0.66 2 2
NFKB1 0.022 0 -9999 0 -10000 0 0
RELA 0.013 0 -9999 0 -10000 0 0
positive regulation of anti-apoptosis 0.018 0.065 -9999 0 -0.39 1 1
NF kappa B1 p50/RelA/I kappa B alpha/beta Arrestin2 0.035 0.058 -9999 0 -0.39 1 1
SRC 0.013 0 -9999 0 -10000 0 0
PI3K 0.016 0.041 -9999 0 -0.48 2 2
NF kappa B1 p50/RelA 0.018 0.065 -9999 0 -0.4 1 1
IKBKB 0.013 0 -9999 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.013 0 -9999 0 -10000 0 0
SYK 0.01 0.042 -9999 0 -0.72 1 1
I kappa B alpha/PIK3R1 0.016 0.069 -9999 0 -0.42 2 2
cell death 0.034 0.056 -9999 0 -0.38 1 1
NF kappa B1 p105/c-Rel 0.016 0.068 -9999 0 -0.46 6 6
LCK -0.032 0.17 -9999 0 -0.67 20 20
BCL3 0.013 0 -9999 0 -10000 0 0
Alternative NF-kappaB pathway

Figure S125.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S125.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer 0.013 0.05 -9999 0 -0.42 4 4
FBXW11 0.013 0 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0 0 -9999 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.013 0 -9999 0 -10000 0 0
CHUK 0.013 0 -9999 0 -10000 0 0
NF kappa B2 p100/RelB -0.006 0.047 -9999 0 -0.6 1 1
NFKB1 0.013 0 -9999 0 -10000 0 0
MAP3K14 0.005 0.068 -9999 0 -0.58 4 4
NF kappa B1 p50/RelB 0.016 0.036 -9999 0 -0.42 2 2
RELB 0.009 0.048 -9999 0 -0.58 2 2
NFKB2 0.013 0 -9999 0 -10000 0 0
NF kappa B2 p52/RelB -0.002 0.029 -9999 0 -0.36 2 2
regulation of B cell activation -0.002 0.029 -9999 0 -0.36 2 2
Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Figure S126.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S126.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SMAD4 0.01 0.042 -9999 0 -0.72 1 1
SMAD2 0.014 0 -9999 0 -10000 0 0
SMAD3 0.039 0.016 -9999 0 -10000 0 0
SMAD3/SMAD4 0.044 0.019 -9999 0 -10000 0 0
SMAD4/Ubc9/PIASy -0.002 0.027 -9999 0 -0.46 1 1
SMAD2/SMAD2/SMAD4 -0.001 0.02 -9999 0 -10000 0 0
PPM1A 0.013 0 -9999 0 -10000 0 0
CALM1 0.013 0 -9999 0 -10000 0 0
SMAD2/SMAD4 0.019 0.025 -9999 0 -0.42 1 1
MAP3K1 0.013 0 -9999 0 -10000 0 0
TRAP-1/SMAD4 0.006 0.092 -9999 0 -0.62 6 6
MAPK3 0.013 0 -9999 0 -10000 0 0
MAPK1 0.013 0 -9999 0 -10000 0 0
NUP214 0.013 0 -9999 0 -10000 0 0
CTDSP1 0.013 0 -9999 0 -10000 0 0
CTDSP2 0.013 0 -9999 0 -10000 0 0
CTDSPL 0.013 0 -9999 0 -10000 0 0
KPNB1 0.013 0 -9999 0 -10000 0 0
TGFBRAP1 -0.002 0.1 -9999 0 -0.72 6 6
UBE2I 0.013 0 -9999 0 -10000 0 0
NUP153 0.013 0 -9999 0 -10000 0 0
KPNA2 0.013 0 -9999 0 -10000 0 0
PIAS4 0.013 0 -9999 0 -10000 0 0
PLK1 signaling events

Figure S127.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S127.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
regulation of centriole-centriole cohesion -0.009 0.025 0.29 2 -10000 0 2
BUB1B 0.021 0.039 -10000 0 -0.43 2 2
PLK1 0.017 0.015 -10000 0 -0.13 1 1
PLK1S1 0.013 0.017 -10000 0 -10000 0 0
KIF2A 0.024 0.013 -10000 0 -10000 0 0
regulation of mitotic centrosome separation 0.017 0.015 -10000 0 -0.13 1 1
GOLGA2 0.01 0.042 -10000 0 -0.72 1 1
Hec1/SPC24 0.025 0.05 -10000 0 -0.39 4 4
WEE1 0.024 0.016 -10000 0 -10000 0 0
cytokinesis 0.026 0.068 -10000 0 -0.76 2 2
PP2A-alpha B56 0.028 0.075 -10000 0 -0.72 3 3
AURKA 0.014 0.027 -10000 0 -0.31 2 2
PICH/PLK1 0.032 0.061 -10000 0 -0.56 3 3
CENPE 0.022 0.029 -10000 0 -0.42 1 1
RhoA/GTP 0.009 0 -10000 0 -10000 0 0
positive regulation of microtubule depolymerization 0.024 0.013 -10000 0 -10000 0 0
PPP2CA 0.013 0 -10000 0 -10000 0 0
FZR1 0.013 0 -10000 0 -10000 0 0
TPX2 0.013 0.027 -10000 0 -0.31 2 2
PAK1 0.01 0.034 -10000 0 -0.58 1 1
SPC24 0.006 0.069 -10000 0 -0.68 3 3
FBXW11 0.013 0 -10000 0 -10000 0 0
CLSPN 0.012 0.036 -10000 0 -0.34 3 3
GORASP1 0.013 0 -10000 0 -10000 0 0
metaphase 0 0.001 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
NLP 0.01 0.007 -10000 0 -10000 0 0
G2 phase of mitotic cell cycle 0 0.001 -10000 0 -0.015 2 2
STAG2 0.013 0 -10000 0 -10000 0 0
GRASP65/GM130/RAB1/GTP -0.001 0.016 -10000 0 -10000 0 0
spindle elongation 0.017 0.015 -10000 0 -0.13 1 1
ODF2 0.012 0.001 -10000 0 -10000 0 0
BUB1 -0.008 0.078 -10000 0 -0.79 3 3
TPT1 0.015 0.007 -10000 0 -10000 0 0
CDC25C 0.015 0.031 -10000 0 -0.51 1 1
CDC25B 0.013 0.001 -10000 0 -10000 0 0
SGOL1 0.009 0.025 -10000 0 -0.29 2 2
RHOA 0.013 0 -10000 0 -10000 0 0
CCNB1/CDK1 -0.002 0.03 -10000 0 -0.51 1 1
CDC14B 0.007 0.046 -10000 0 -0.56 2 2
CDC20 0.01 0.042 -10000 0 -0.72 1 1
PLK1/PBIP1 -0.002 0.019 -10000 0 -0.29 1 1
mitosis 0 0.004 0.047 2 -10000 0 2
FBXO5 0.022 0.01 -10000 0 -10000 0 0
CDC2 0.001 0.001 -10000 0 -0.021 1 1
NDC80 0.011 0.034 -10000 0 -0.58 1 1
metaphase plate congression 0.016 0.008 -10000 0 -10000 0 0
ERCC6L -0.006 0.059 -10000 0 -0.57 3 3
NLP/gamma Tubulin 0.014 0.008 -10000 0 -10000 0 0
microtubule cytoskeleton organization 0.015 0.007 -10000 0 -10000 0 0
G2/M transition DNA damage checkpoint 0 0.001 -10000 0 -10000 0 0
PPP1R12A 0.013 0 -10000 0 -10000 0 0
interphase 0 0.001 -10000 0 -10000 0 0
PLK1/PRC1-2 0.027 0.041 -10000 0 -0.46 2 2
GRASP65/GM130/RAB1/GTP/PLK1 -0.002 0.022 -10000 0 -0.36 1 1
RAB1A 0.013 0 -10000 0 -10000 0 0
prophase 0 0 -10000 0 -10000 0 0
Aurora A/BORA 0.018 0.03 -10000 0 -0.3 2 2
mitotic prometaphase 0 0 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.033 0.024 -10000 0 -10000 0 0
microtubule-based process 0.02 0.043 -10000 0 -0.49 2 2
Golgi organization 0.017 0.015 -10000 0 -0.13 1 1
Cohesin/SA2 -0.001 0.009 -10000 0 -10000 0 0
PPP1CB/MYPT1 0.018 0.002 -10000 0 -10000 0 0
KIF20A 0.008 0.06 -10000 0 -0.72 2 2
APC/C/CDC20 0.022 0.034 -10000 0 -0.53 1 1
PPP2R1A 0.013 0 -10000 0 -10000 0 0
chromosome segregation -0.002 0.018 -10000 0 -0.29 1 1
PRC1 0.013 0 -10000 0 -10000 0 0
ECT2 0.018 0.051 -10000 0 -0.4 4 4
C13orf34 0.018 0.029 -10000 0 -0.3 2 2
NUDC 0.016 0.008 -10000 0 -10000 0 0
regulation of attachment of spindle microtubules to kinetochore 0.021 0.039 -10000 0 -0.43 2 2
spindle assembly 0.017 0.011 -10000 0 -10000 0 0
spindle stabilization 0.013 0.017 -10000 0 -10000 0 0
APC/C/HCDH1 0.014 0.04 -10000 0 -0.48 2 2
MKLP2/PLK1 0.02 0.043 -10000 0 -0.49 2 2
CCNB1 0.011 0.043 -10000 0 -0.73 1 1
PPP1CB 0.013 0 -10000 0 -10000 0 0
BTRC 0.013 0 -10000 0 -10000 0 0
ROCK2 0.019 0.053 -10000 0 -0.5 3 3
TUBG1 0.015 0.007 -10000 0 -10000 0 0
G2/M transition of mitotic cell cycle -0.002 0.029 -10000 0 -0.5 1 1
MLF1IP 0.01 0.026 -10000 0 -0.44 1 1
INCENP 0.01 0.043 -10000 0 -0.73 1 1
Insulin-mediated glucose transport

Figure S128.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S128.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Insulin responsive Vesicles -0.018 0.056 -9999 0 -0.44 1 1
CaM/Ca2+ 0.009 0 -9999 0 -10000 0 0
AKT1 0.013 0 -9999 0 -10000 0 0
AKT2 0.013 0 -9999 0 -10000 0 0
STXBP4 0.013 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
mol:glucose 0.027 0.078 -9999 0 -0.49 1 1
YWHAZ 0.013 0 -9999 0 -10000 0 0
CALM1 0.013 0 -9999 0 -10000 0 0
YWHAQ 0.013 0 -9999 0 -10000 0 0
TBC1D4 0.021 0.026 -9999 0 -0.42 1 1
mol:Ca2+ 0 0 -9999 0 -10000 0 0
YWHAH 0.013 0 -9999 0 -10000 0 0
YWHAB 0.013 0 -9999 0 -10000 0 0
SNARE/Synip 0 0 -9999 0 -10000 0 0
YWHAG 0.013 0 -9999 0 -10000 0 0
ASIP -0.017 0.12 -9999 0 -0.58 13 13
PRKCI 0.013 0 -9999 0 -10000 0 0
AS160/CaM/Ca2+ 0.009 0 -9999 0 -10000 0 0
RHOQ 0.013 0 -9999 0 -10000 0 0
GYS1 0.03 0 -9999 0 -10000 0 0
PRKCZ 0.01 0.042 -9999 0 -0.72 1 1
TRIP10 0.013 0 -9999 0 -10000 0 0
TC10/GTP/CIP4/Exocyst 0 0 -9999 0 -10000 0 0
AS160/14-3-3 0.039 0.04 -9999 0 -10000 0 0
VAMP2 0.013 0 -9999 0 -10000 0 0
SLC2A4 0.027 0.083 -9999 0 -0.55 1 1
STX4 0.013 0 -9999 0 -10000 0 0
GSK3B 0.025 0 -9999 0 -10000 0 0
SFN -0.004 0.11 -9999 0 -0.7 7 7
LNPEP 0.005 0.073 -9999 0 -0.72 3 3
YWHAE 0.013 0 -9999 0 -10000 0 0
Class I PI3K signaling events mediated by Akt

Figure S129.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S129.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.021 0.026 -10000 0 -0.42 1 1
BAD/BCL-XL/YWHAZ 0.031 0.02 -10000 0 -10000 0 0
CDKN1B 0.036 0 -10000 0 -10000 0 0
CDKN1A 0.035 0.023 -10000 0 -0.37 1 1
FRAP1 0 0 -10000 0 -10000 0 0
PRKDC 0.013 0 -10000 0 -10000 0 0
FOXO3 0.035 0.023 -10000 0 -0.37 1 1
AKT1 0 0 -10000 0 -10000 0 0
BAD 0.013 0 -10000 0 -10000 0 0
AKT3 0.011 0.048 -10000 0 -0.41 3 3
mol:GTP 0 0 -10000 0 -10000 0 0
FOXO4 0.033 0.033 -10000 0 -0.37 2 2
AKT1/ASK1 0.033 0.023 -10000 0 -0.36 1 1
BAD/YWHAZ 0 0 -10000 0 -10000 0 0
RICTOR 0.013 0 -10000 0 -10000 0 0
RAF1 0.013 0 -10000 0 -10000 0 0
JNK cascade 0.001 0.02 0.35 1 -10000 0 1
TSC1 0.036 0 -10000 0 -10000 0 0
YWHAZ 0.013 0 -10000 0 -10000 0 0
AKT1/RAF1 0.036 0 -10000 0 -10000 0 0
EP300 0.013 0 -10000 0 -10000 0 0
mol:GDP 0.03 0 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 0 0 -10000 0 -10000 0 0
TSC2 0.036 0 -10000 0 -10000 0 0
YWHAQ 0.013 0 -10000 0 -10000 0 0
TBC1D4 0.022 0.021 -10000 0 -0.35 1 1
MAP3K5 0.01 0.042 -10000 0 -0.72 1 1
MAPKAP1 0.013 0 -10000 0 -10000 0 0
negative regulation of cell cycle -0.039 0.025 -10000 0 -10000 0 0
YWHAH 0.013 0 -10000 0 -10000 0 0
AKT1S1 0.036 0 -10000 0 -10000 0 0
CASP9 0.036 0 -10000 0 -10000 0 0
YWHAB 0.013 0 -10000 0 -10000 0 0
p27Kip1/KPNA1 0.042 0 -10000 0 -10000 0 0
GBL 0 0 -10000 0 -10000 0 0
PDK1/Src/Hsp90 0 0 -10000 0 -10000 0 0
YWHAE 0.013 0 -10000 0 -10000 0 0
SRC 0.013 0 -10000 0 -10000 0 0
AKT2/p21CIP1 -0.001 0.02 -10000 0 -0.36 1 1
KIAA1303 0 0 -10000 0 -10000 0 0
mTOR/RHEB/GTP/Raptor/GBL 0.018 0 -10000 0 -10000 0 0
CHUK 0.036 0 -10000 0 -10000 0 0
BAD/BCL-XL 0.047 0.017 -10000 0 -10000 0 0
mTORC2 0.016 0 -10000 0 -10000 0 0
AKT2 0.017 0 -10000 0 -10000 0 0
FOXO1-3a-4/14-3-3 family 0.052 0.034 -10000 0 -10000 0 0
PDPK1 0.013 0 -10000 0 -10000 0 0
MDM2 0.035 0.018 -10000 0 -10000 0 0
MAPKKK cascade -0.036 0 -10000 0 -10000 0 0
MDM2/Cbp/p300 0.047 0.017 -10000 0 -10000 0 0
TSC1/TSC2 0.042 0 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.044 0.016 -10000 0 -10000 0 0
glucose import -0.017 0.12 -10000 0 -0.42 9 9
mTOR/RHEB/GDP/Raptor/GBL/PRAS40 0.031 0 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
SLC2A4 -0.017 0.12 -10000 0 -0.42 9 9
GSK3A 0.036 0 -10000 0 -10000 0 0
FOXO1 0.035 0.023 -10000 0 -0.37 1 1
GSK3B 0.036 0 -10000 0 -10000 0 0
SFN -0.004 0.11 -10000 0 -0.7 7 7
G1/S transition of mitotic cell cycle 0.042 0 -10000 0 -10000 0 0
p27Kip1/14-3-3 family 0.041 0.037 -10000 0 -10000 0 0
PRKACA 0.013 0 -10000 0 -10000 0 0
KPNA1 0.013 0 -10000 0 -10000 0 0
HSP90AA1 0.013 0 -10000 0 -10000 0 0
YWHAG 0.013 0 -10000 0 -10000 0 0
RHEB 0.013 0 -10000 0 -10000 0 0
CREBBP 0.013 0 -10000 0 -10000 0 0
Sumoylation by RanBP2 regulates transcriptional repression

Figure S130.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S130.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.013 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC4 0 0 -9999 0 -10000 0 0
MDM2/SUMO1 0.028 0.018 -9999 0 -10000 0 0
HDAC4 0.013 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC1 0 0 -9999 0 -10000 0 0
SUMO1 0.013 0 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1 0.017 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
XPO1 0.028 0 -9999 0 -10000 0 0
EntrezGene:23636 0 0 -9999 0 -10000 0 0
RAN 0.013 0 -9999 0 -10000 0 0
EntrezGene:8021 0 0 -9999 0 -10000 0 0
RANBP2 0.013 0 -9999 0 -10000 0 0
SUMO1/HDAC4 0.03 0 -9999 0 -10000 0 0
SUMO1/HDAC1 0.03 0 -9999 0 -10000 0 0
RANGAP1 0.013 0 -9999 0 -10000 0 0
MDM2/SUMO1/SUMO1 0.029 0.034 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 0.021 0 -9999 0 -10000 0 0
Ran/GTP 0.026 0 -9999 0 -10000 0 0
EntrezGene:23225 0 0 -9999 0 -10000 0 0
MDM2 0.011 0.034 -9999 0 -0.58 1 1
UBE2I 0.013 0 -9999 0 -10000 0 0
Ran/GTP/Exportin 1 0.032 0 -9999 0 -10000 0 0
NPC 0 0 -9999 0 -10000 0 0
PIAS2 0.009 0.048 -9999 0 -0.58 2 2
PIAS1 0.013 0 -9999 0 -10000 0 0
EntrezGene:9972 0 0 -9999 0 -10000 0 0
Arf1 pathway

Figure S131.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S131.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
coatomer protein complex -0.001 0.014 -9999 0 -10000 0 0
EntrezGene:79658 0 0 -9999 0 -10000 0 0
ARF1/GDP/Membrin/GBF1/p115/Brefeldin A 0.02 0 -9999 0 -10000 0 0
AP2 0.017 0.025 -9999 0 -0.42 1 1
mol:DAG 0 0 -9999 0 -10000 0 0
Arfaptin 2/Rac/GTP 0 0 -9999 0 -10000 0 0
CLTB 0.011 0.034 -9999 0 -0.58 1 1
coatomer protein complex/ARF1/GTP/ER cargo protein 0.023 0.017 -9999 0 -10000 0 0
CD4 -0.007 0.12 -9999 0 -0.72 8 8
CLTA 0.011 0.034 -9999 0 -0.58 1 1
mol:GTP 0.002 0 -9999 0 -10000 0 0
ARFGAP1 0.011 0 -9999 0 -10000 0 0
mol:PI-4-5-P2 0 0 -9999 0 -10000 0 0
ARF1/GTP 0 0 -9999 0 -10000 0 0
coatomer protein complex/ARF1/GTP/ARF-GAP1/ER cargo protein 0.026 0.011 -9999 0 -10000 0 0
mol:Choline 0 0 -9999 0 -10000 0 0
mol:GDP 0 0 -9999 0 -10000 0 0
ARF1 0.013 0 -9999 0 -10000 0 0
DDEF1 0 0 -9999 0 -10000 0 0
ARF1/GDP 0 0 -9999 0 -10000 0 0
AP2M1 0.011 0.034 -9999 0 -0.58 1 1
EntrezGene:1313 0 0 -9999 0 -10000 0 0
actin filament polymerization 0.016 0 -9999 0 -10000 0 0
Rac/GTP 0.011 0 -9999 0 -10000 0 0
ARF1/GTP/GGA3/ARF-GAP1 0.024 0 -9999 0 -10000 0 0
ARFIP2 0.011 0 -9999 0 -10000 0 0
COPA 0.013 0 -9999 0 -10000 0 0
RAC1 0.013 0 -9999 0 -10000 0 0
ARF1/GTP/coatomer protein complex 0.024 0.012 -9999 0 -10000 0 0
ARF1/GTP/ARHGAP10 0 0 -9999 0 -10000 0 0
GGA3 0.013 0 -9999 0 -10000 0 0
ARF1/GTP/Membrin 0 0 -9999 0 -10000 0 0
AP2A1 0.013 0 -9999 0 -10000 0 0
coatomer protein complex/ARF1/GTP/ARF-GAP1 0.025 0.013 -9999 0 -10000 0 0
ARF1/GDP/Membrin 0.018 0 -9999 0 -10000 0 0
Arfaptin 2/Rac/GDP 0 0 -9999 0 -10000 0 0
CYTH2 0.013 0 -9999 0 -10000 0 0
ARF1/GTP/GGA3 0 0 -9999 0 -10000 0 0
mol:ATP 0 0 -9999 0 -10000 0 0
Rac/GDP 0.009 0 -9999 0 -10000 0 0
mol:Brefeldin A 0 0 -9999 0 -10000 0 0
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex/Coatomer protein complex/ARF1/GTP 0.025 0.048 -9999 0 -10000 0 0
PLD2 0 0 -9999 0 -10000 0 0
ARF-GAP1/v-SNARE 0.011 0 -9999 0 -10000 0 0
PIP5K1A 0 0 -9999 0 -10000 0 0
ARF1/GTP/Membrin/GBF1/p115 0 0 -9999 0 -10000 0 0
mol:Phosphatic acid 0 0 -9999 0 -10000 0 0
mol:Phosphatidic acid 0 0 -9999 0 -10000 0 0
KDEL Receptor/Ligand/ARF-GAP1 0.011 0 -9999 0 -10000 0 0
GOSR2 0 0 -9999 0 -10000 0 0
USO1 0 0 -9999 0 -10000 0 0
GBF1 0 0 -9999 0 -10000 0 0
ARF1/GTP/Arfaptin 2 0 0 -9999 0 -10000 0 0
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex -0.013 0.077 -9999 0 -0.45 9 9
Inferred Pathway Levels Matrix

Table 3.  Get Full Table First 10 out of 7202 rows and 4 out of 303 columns in the PARADIGM inferred pathway levels matrix.

pid_entity TCGA.IQ.7632 TCGA.IQ.7631 TCGA.IQ.7630 TCGA.HD.7917
109_MAP3K5 0.053 0.053 0.053 0.053
47_PPARGC1A 0.013 -0.59 0.013 0.013
105_BMP4 0.013 0.013 0.013 0.013
105_BMP6 0.013 0.013 0.013 0.013
105_BMP7 0.013 0.013 0.013 0.013
105_BMP2 0.013 0.013 0.013 0.013
131_RELN/VLDLR -0.42 0.033 -0.42 0.033
30_TGFB1/TGF beta receptor Type II 0.012 0.012 0.017 0.012
84_STAT5B -0.079 -0.08 -0.044 0.043
84_STAT5A -0.079 -0.08 -0.044 0.043
Methods & Data
Input

  • Expression Data Normalization = Expression data was not used in this analysis.

  • mRNASeq Expression File Used = /xchip/cga/gdac-prod/tcga-gdac/jobResults/mRNAseq_preprocessor/HNSC-TP/2282191/0.mRNAseq_preprocessor.Finished/HNSC-TP.uncv2.mRNAseq_RSEM_normalized_log2.txt

  • Copy Number File Used = Copy number data was not used in this analysis.

Data Sets and Pathway Interactions

Both copy number and expression data are incorporated into PARADIGM's inference. Whenever normal tissue controls are available for analysis in the expression data, each patient's gene-value is normalized by subtracting the gene's median level observed in the normal control. Copy number data is also normalized to reflect the difference in copy number between a gene's levels detected in tumor versus control (e.g. blood normal). The collection of pathways used by PARADIGM includes those from NCI-PID on September 15, 2009 containing 131 pathways, 11,563 interactions, and 7,204 entities. All gene identifiers were translated into HUGO standard identifiers wherever possible. We refer to molecular entities as "concepts," which include gene products such as proteins and miRNAs, small molecules, protein complexes, and abstract concepts. Each concept is represented as "node" in PARADIGM's graphical model. The abstract concepts correspond to general cellular processes (such as "apoptosis" or "DNA damage response") and families of genes that share functional activity such as the RAS family of signal transducers. Various types of concept-concept interactions are included in the pathways including protein-protein interactions, transcriptional regulatory interactions, and protein modifications such as phosphorylation and ubiquitinylation interactions.

Pathway Inference Method

The PARADIGM algorithm (described in PMID: 20529912) assigns an integrated pathway level (IPL) reflecting the activity of a concept determined through a belief propagation strategy. The belief propagation is given the copy number and gene expression measurements of all of the genes and iteratively updates hidden states reflecting the activities of all of the genes in a pathway so as to maximize the likelihood of the observed data given the interactions in the pathway. In the end, the inferred level of a concept reflects both the data observed for the concept and the neighborhood of activity surrounding the concept.

Determining significantly altered levels

The significance of the IPL obtained for each concept in each patient sample is assessed using a permutation analysis. Importantly, the permutation analysis preserves data tuples so as to preserve any implicit correlations between the different data modalities. For example, genes that are deleted have concomitantly lower expression levels. Preserving the copy number and expression pairs therefore retains this data property. The simulation therefore makes "null samples" by permuting data tuples across all of the genes in the genome so that each gene in a null sample is associated with a random tuple of another gene with equal probability. This approach has the added benefit of preserving the pathway structure so that every observed IPL can be compared to a distribution of random IPLs derived from exactly the same interaction context. PARADIGM inferences are then obtained for 1000 "null" patients and serve as a background distribution to contrast the observed IPLs against. Pathway concepts are excluded from further analysis if they did not obtain a minimum IPL of 0.5 in any patient sample both observed or simulated.

An IPL I(i,j) for concept i in sample j, is considered to be deviated if its absolute level is two standard deviations from the average level observed for concept i in the 1000 null samples. The degree to which a concept has significantly altered levels across a patient cohort is summarized in the proportion of deviated samples (PDS) score. For example, a protein with a PDS of 0.10 reflects that the protein's level of activity was inferred to be significantly higher or lower in tumors compared to normal in 10% of the patient samples. An average PDS for a pathway is also reported by computing the mean PDS over all concepts in the pathway.

Download Results

This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.

References
[2] Charles J. Vaske, Stephen C. Benz, J. Zachary Sanborn, Dent Earl, Christopher Szeto, Jingchun Zhu, David Haussler, and Joshua M. Stuart, Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM, Bioinformatics 12(26):237-245 (2010)
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