HotNet pathway analysis of mutation and copy number data
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (Primary solid tumor)
15 January 2014
|
analyses__2014_01_15
Maintainer Information
Citation Information
Maintained by Hailei Zhang
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2014):
HotNet pathway analysis of mutation and copy number data.
Broad Institute of MIT and Harvard.
doi:10.7908/C1D50KFC
Overview
Introduction
Summary
There were 25 significant subnetworks identified in HotNet analysis.
Results
Significant subnetworks
HotNet identifies 25 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.
Table 1. Get Full Table Top 10 out of 25 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.
| Network | No.ofgenes | p-value | RepeatTimes |
|---|---|---|---|
| ROBO1(21),ROBO2(22),SLIT3(16) | 3 | 5e-04 | 2 |
| ARHGEF2(23),F11R(23),CGN(24) | 3 | 5e-04 | 1 |
| BACE1(28),APH1A(23),NCSTN(23) | 3 | 5e-04 | 1 |
| CD44(4),CNKSR1(7),ARHGEF1(13) | 3 | 5e-04 | 1 |
| CIC(14),GABPB1(8),SEC62(33) | 3 | 5e-04 | 1 |
| COPS2(7),CUL5(27),IRF8(6) | 3 | 5e-04 | 1 |
| CSF1R(17),RASA1(18),SOS1(9) | 3 | 5e-04 | 1 |
| E2F6(9),EZH2(10),DNMT3A(9) | 3 | 5e-04 | 1 |
| EIF4G1(34),EIF4A1(14),EIF5(6) | 3 | 5e-04 | 1 |
| ERBB2(7),BTC(11),MUC4(33) | 3 | 5e-04 | 1 |
Methods & Data
Copyright © 2014
Broad Institute TCGA GDAC as part of the TCGA Research Network.
All rights reserved.