This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 8 different clustering approaches and 12 clinical features across 73 patients, no significant finding detected with P value < 0.05 and Q value < 0.25.
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3 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes do not correlate to any clinical features.
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3 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes do not correlate to any clinical features.
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CNMF clustering analysis on sequencing-based mRNA expression data identified 3 subtypes that do not correlate to any clinical features.
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Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 2 subtypes that do not correlate to any clinical features.
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4 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes do not correlate to any clinical features.
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3 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes do not correlate to any clinical features.
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3 subtypes identified in current cancer cohort by 'MIRseq Mature CNMF subtypes'. These subtypes do not correlate to any clinical features.
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3 subtypes identified in current cancer cohort by 'MIRseq Mature cHierClus subtypes'. These subtypes do not correlate to any clinical features.
Clinical Features |
Statistical Tests |
Copy Number Ratio CNMF subtypes |
METHLYATION CNMF |
RNAseq CNMF subtypes |
RNAseq cHierClus subtypes |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRseq Mature CNMF subtypes |
MIRseq Mature cHierClus subtypes |
Time to Death | logrank test |
0.104 (1.00) |
0.188 (1.00) |
0.929 (1.00) |
0.256 (1.00) |
0.589 (1.00) |
0.633 (1.00) |
0.504 (1.00) |
0.196 (1.00) |
AGE | ANOVA |
0.922 (1.00) |
0.455 (1.00) |
0.827 (1.00) |
0.706 (1.00) |
0.632 (1.00) |
0.672 (1.00) |
0.688 (1.00) |
0.807 (1.00) |
NEOPLASM DISEASESTAGE | Chi-square test |
0.0408 (1.00) |
0.479 (1.00) |
0.0575 (1.00) |
0.257 (1.00) |
0.14 (1.00) |
0.217 (1.00) |
0.085 (1.00) |
0.184 (1.00) |
PATHOLOGY T STAGE | Fisher's exact test |
0.239 (1.00) |
0.0983 (1.00) |
0.0368 (1.00) |
0.226 (1.00) |
0.0465 (1.00) |
0.102 (1.00) |
0.145 (1.00) |
0.243 (1.00) |
PATHOLOGY N STAGE | Fisher's exact test |
0.159 (1.00) |
1 (1.00) |
0.0188 (1.00) |
0.786 (1.00) |
0.158 (1.00) |
0.083 (1.00) |
0.0871 (1.00) |
0.0213 (1.00) |
PATHOLOGY M STAGE | Chi-square test |
0.0172 (1.00) |
0.251 (1.00) |
0.565 (1.00) |
0.452 (1.00) |
0.431 (1.00) |
0.406 (1.00) |
0.49 (1.00) |
0.458 (1.00) |
GENDER | Fisher's exact test |
0.393 (1.00) |
0.017 (1.00) |
0.709 (1.00) |
1 (1.00) |
0.669 (1.00) |
0.913 (1.00) |
1 (1.00) |
0.73 (1.00) |
HISTOLOGICAL TYPE | Chi-square test |
0.645 (1.00) |
0.422 (1.00) |
0.587 (1.00) |
0.429 (1.00) |
0.225 (1.00) |
0.807 (1.00) |
0.63 (1.00) |
0.471 (1.00) |
NUMBERPACKYEARSSMOKED | ANOVA |
0.24 (1.00) |
0.573 (1.00) |
0.9 (1.00) |
0.94 (1.00) |
0.604 (1.00) |
0.789 (1.00) |
0.415 (1.00) |
0.689 (1.00) |
YEAROFTOBACCOSMOKINGONSET | ANOVA |
0.849 (1.00) |
0.585 (1.00) |
0.597 (1.00) |
0.343 (1.00) |
0.594 (1.00) |
0.497 (1.00) |
0.54 (1.00) |
0.877 (1.00) |
COMPLETENESS OF RESECTION | Chi-square test |
0.0485 (1.00) |
0.0554 (1.00) |
0.0473 (1.00) |
0.0724 (1.00) |
0.0238 (1.00) |
0.228 (1.00) |
0.0344 (1.00) |
0.0387 (1.00) |
NUMBER OF LYMPH NODES | ANOVA |
0.0107 (1.00) |
0.154 (1.00) |
0.2 (1.00) |
0.844 (1.00) |
0.477 (1.00) |
0.309 (1.00) |
0.874 (1.00) |
0.0986 (1.00) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 17 | 40 | 15 |
P value = 0.104 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 69 | 29 | 0.0 - 49.4 (7.2) |
subtype1 | 16 | 6 | 0.0 - 20.8 (6.6) |
subtype2 | 38 | 15 | 0.1 - 49.4 (8.7) |
subtype3 | 15 | 8 | 0.1 - 19.7 (4.8) |
P value = 0.922 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 72 | 65.9 (10.7) |
subtype1 | 17 | 65.0 (10.3) |
subtype2 | 40 | 66.1 (11.2) |
subtype3 | 15 | 66.4 (10.4) |
P value = 0.0408 (Chi-square test), Q value = 1
nPatients | STAGE IA | STAGE IB | STAGE IIA | STAGE IIB | STAGE III | STAGE IV |
---|---|---|---|---|---|---|
ALL | 2 | 4 | 11 | 50 | 2 | 3 |
subtype1 | 0 | 0 | 4 | 10 | 0 | 3 |
subtype2 | 2 | 3 | 7 | 26 | 2 | 0 |
subtype3 | 0 | 1 | 0 | 14 | 0 | 0 |
P value = 0.239 (Fisher's exact test), Q value = 1
nPatients | T1+T2 | T3+T4 |
---|---|---|
ALL | 7 | 65 |
subtype1 | 0 | 17 |
subtype2 | 6 | 34 |
subtype3 | 1 | 14 |
P value = 0.159 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 18 | 53 |
subtype1 | 5 | 12 |
subtype2 | 12 | 27 |
subtype3 | 1 | 14 |
P value = 0.0172 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 39 | 3 | 30 |
subtype1 | 10 | 3 | 4 |
subtype2 | 20 | 0 | 20 |
subtype3 | 9 | 0 | 6 |
P value = 0.393 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 36 | 36 |
subtype1 | 9 | 8 |
subtype2 | 22 | 18 |
subtype3 | 5 | 10 |
P value = 0.645 (Chi-square test), Q value = 1
nPatients | PANCREAS-ADENOCARCINOMA DUCTAL TYPE | PANCREAS-ADENOCARCINOMA-OTHER SUBTYPE | PANCREAS-COLLOID (MUCINOUS NON-CYSTIC) CARCINOMA |
---|---|---|---|
ALL | 64 | 5 | 2 |
subtype1 | 14 | 2 | 0 |
subtype2 | 36 | 2 | 2 |
subtype3 | 14 | 1 | 0 |
P value = 0.24 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 21 | 24.5 (14.5) |
subtype1 | 6 | 19.2 (13.4) |
subtype2 | 10 | 23.0 (16.4) |
subtype3 | 5 | 33.8 (8.2) |
P value = 0.849 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 18 | 1970.9 (13.8) |
subtype1 | 5 | 1973.6 (11.1) |
subtype2 | 8 | 1968.9 (16.5) |
subtype3 | 5 | 1971.4 (14.0) |
P value = 0.0485 (Chi-square test), Q value = 1
nPatients | R0 | R1 | RX |
---|---|---|---|
ALL | 43 | 24 | 2 |
subtype1 | 7 | 8 | 0 |
subtype2 | 30 | 8 | 1 |
subtype3 | 6 | 8 | 1 |
P value = 0.0107 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 71 | 2.9 (3.1) |
subtype1 | 17 | 1.9 (1.5) |
subtype2 | 39 | 2.5 (2.9) |
subtype3 | 15 | 4.9 (4.2) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 23 | 31 | 19 |
P value = 0.188 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 70 | 29 | 0.0 - 49.4 (7.4) |
subtype1 | 22 | 7 | 0.0 - 36.2 (9.0) |
subtype2 | 29 | 10 | 0.1 - 49.4 (7.7) |
subtype3 | 19 | 12 | 0.3 - 21.9 (5.0) |
P value = 0.455 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 73 | 65.7 (10.7) |
subtype1 | 23 | 63.5 (10.3) |
subtype2 | 31 | 66.4 (10.3) |
subtype3 | 19 | 67.4 (12.0) |
P value = 0.479 (Chi-square test), Q value = 1
nPatients | STAGE IA | STAGE IB | STAGE IIA | STAGE IIB | STAGE III | STAGE IV |
---|---|---|---|---|---|---|
ALL | 2 | 4 | 11 | 51 | 2 | 3 |
subtype1 | 0 | 0 | 5 | 16 | 0 | 2 |
subtype2 | 2 | 2 | 4 | 22 | 1 | 0 |
subtype3 | 0 | 2 | 2 | 13 | 1 | 1 |
P value = 0.0983 (Fisher's exact test), Q value = 1
nPatients | T1+T2 | T3+T4 |
---|---|---|
ALL | 7 | 66 |
subtype1 | 0 | 23 |
subtype2 | 5 | 26 |
subtype3 | 2 | 17 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 18 | 54 |
subtype1 | 6 | 17 |
subtype2 | 8 | 23 |
subtype3 | 4 | 14 |
P value = 0.251 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 39 | 3 | 31 |
subtype1 | 11 | 2 | 10 |
subtype2 | 15 | 0 | 16 |
subtype3 | 13 | 1 | 5 |
P value = 0.017 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 36 | 37 |
subtype1 | 14 | 9 |
subtype2 | 18 | 13 |
subtype3 | 4 | 15 |
P value = 0.422 (Chi-square test), Q value = 1
nPatients | PANCREAS-ADENOCARCINOMA DUCTAL TYPE | PANCREAS-ADENOCARCINOMA-OTHER SUBTYPE | PANCREAS-COLLOID (MUCINOUS NON-CYSTIC) CARCINOMA |
---|---|---|---|
ALL | 65 | 5 | 2 |
subtype1 | 19 | 3 | 0 |
subtype2 | 28 | 2 | 1 |
subtype3 | 18 | 0 | 1 |
P value = 0.573 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 22 | 24.5 (14.1) |
subtype1 | 7 | 20.8 (14.1) |
subtype2 | 8 | 23.9 (18.5) |
subtype3 | 7 | 29.0 (7.8) |
P value = 0.585 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 19 | 1971.7 (13.9) |
subtype1 | 6 | 1975.8 (13.6) |
subtype2 | 6 | 1967.2 (14.0) |
subtype3 | 7 | 1972.1 (15.1) |
P value = 0.0554 (Chi-square test), Q value = 1
nPatients | R0 | R1 | RX |
---|---|---|---|
ALL | 43 | 24 | 2 |
subtype1 | 10 | 10 | 1 |
subtype2 | 24 | 5 | 0 |
subtype3 | 9 | 9 | 1 |
P value = 0.154 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 72 | 2.8 (3.1) |
subtype1 | 23 | 2.1 (1.8) |
subtype2 | 31 | 2.7 (2.8) |
subtype3 | 18 | 4.0 (4.5) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 32 | 18 | 20 |
P value = 0.929 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 67 | 26 | 0.0 - 49.4 (7.2) |
subtype1 | 31 | 11 | 0.1 - 28.0 (8.1) |
subtype2 | 18 | 4 | 0.0 - 19.3 (1.4) |
subtype3 | 18 | 11 | 0.1 - 49.4 (7.2) |
P value = 0.827 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 70 | 65.6 (10.7) |
subtype1 | 32 | 65.2 (10.7) |
subtype2 | 18 | 65.1 (10.1) |
subtype3 | 20 | 66.9 (11.5) |
P value = 0.0575 (Chi-square test), Q value = 1
nPatients | STAGE IA | STAGE IB | STAGE IIA | STAGE IIB | STAGE III | STAGE IV |
---|---|---|---|---|---|---|
ALL | 2 | 4 | 10 | 50 | 2 | 2 |
subtype1 | 1 | 0 | 6 | 23 | 0 | 2 |
subtype2 | 0 | 0 | 1 | 16 | 1 | 0 |
subtype3 | 1 | 4 | 3 | 11 | 1 | 0 |
P value = 0.0368 (Fisher's exact test), Q value = 1
nPatients | T1+T2 | T3+T4 |
---|---|---|
ALL | 7 | 63 |
subtype1 | 1 | 31 |
subtype2 | 1 | 17 |
subtype3 | 5 | 15 |
P value = 0.0188 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 17 | 52 |
subtype1 | 7 | 24 |
subtype2 | 1 | 17 |
subtype3 | 9 | 11 |
P value = 0.565 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 37 | 2 | 31 |
subtype1 | 16 | 2 | 14 |
subtype2 | 11 | 0 | 7 |
subtype3 | 10 | 0 | 10 |
P value = 0.709 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 36 | 34 |
subtype1 | 18 | 14 |
subtype2 | 8 | 10 |
subtype3 | 10 | 10 |
P value = 0.587 (Chi-square test), Q value = 1
nPatients | PANCREAS-ADENOCARCINOMA DUCTAL TYPE | PANCREAS-ADENOCARCINOMA-OTHER SUBTYPE | PANCREAS-COLLOID (MUCINOUS NON-CYSTIC) CARCINOMA |
---|---|---|---|
ALL | 62 | 5 | 2 |
subtype1 | 27 | 2 | 2 |
subtype2 | 17 | 1 | 0 |
subtype3 | 18 | 2 | 0 |
P value = 0.9 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 22 | 24.5 (14.1) |
subtype1 | 12 | 25.7 (10.5) |
subtype2 | 7 | 23.7 (19.0) |
subtype3 | 3 | 21.7 (19.6) |
P value = 0.597 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 19 | 1971.7 (13.9) |
subtype1 | 11 | 1974.5 (14.2) |
subtype2 | 6 | 1970.5 (14.3) |
subtype3 | 2 | 1960.5 (10.6) |
P value = 0.0473 (Chi-square test), Q value = 1
nPatients | R0 | R1 | RX |
---|---|---|---|
ALL | 40 | 24 | 2 |
subtype1 | 15 | 14 | 1 |
subtype2 | 8 | 8 | 1 |
subtype3 | 17 | 2 | 0 |
P value = 0.2 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 69 | 2.9 (3.2) |
subtype1 | 31 | 2.6 (2.0) |
subtype2 | 18 | 4.1 (4.0) |
subtype3 | 20 | 2.4 (3.6) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 1 | 30 | 39 |
P value = 0.256 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 66 | 25 | 0.0 - 49.4 (7.2) |
subtype2 | 28 | 11 | 0.1 - 49.4 (7.4) |
subtype3 | 38 | 14 | 0.0 - 28.0 (5.2) |
P value = 0.706 (t-test), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 69 | 65.7 (10.7) |
subtype2 | 30 | 65.1 (11.2) |
subtype3 | 39 | 66.1 (10.5) |
P value = 0.257 (Chi-square test), Q value = 1
nPatients | STAGE IA | STAGE IB | STAGE IIA | STAGE IIB | STAGE III | STAGE IV |
---|---|---|---|---|---|---|
ALL | 2 | 4 | 10 | 49 | 2 | 2 |
subtype2 | 1 | 3 | 3 | 21 | 2 | 0 |
subtype3 | 1 | 1 | 7 | 28 | 0 | 2 |
P value = 0.226 (Fisher's exact test), Q value = 1
nPatients | T1+T2 | T3+T4 |
---|---|---|
ALL | 7 | 62 |
subtype2 | 5 | 25 |
subtype3 | 2 | 37 |
P value = 0.786 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 17 | 51 |
subtype2 | 8 | 22 |
subtype3 | 9 | 29 |
P value = 0.452 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 36 | 2 | 31 |
subtype2 | 16 | 0 | 14 |
subtype3 | 20 | 2 | 17 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 35 | 34 |
subtype2 | 15 | 15 |
subtype3 | 20 | 19 |
P value = 0.429 (Chi-square test), Q value = 1
nPatients | PANCREAS-ADENOCARCINOMA DUCTAL TYPE | PANCREAS-ADENOCARCINOMA-OTHER SUBTYPE | PANCREAS-COLLOID (MUCINOUS NON-CYSTIC) CARCINOMA |
---|---|---|---|
ALL | 61 | 5 | 2 |
subtype2 | 28 | 2 | 0 |
subtype3 | 33 | 3 | 2 |
P value = 0.94 (t-test), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 21 | 24.7 (14.4) |
subtype2 | 8 | 24.4 (18.4) |
subtype3 | 13 | 24.9 (12.2) |
P value = 0.343 (t-test), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 18 | 1970.8 (13.7) |
subtype2 | 6 | 1966.0 (14.9) |
subtype3 | 12 | 1973.2 (13.0) |
P value = 0.0724 (Chi-square test), Q value = 1
nPatients | R0 | R1 | RX |
---|---|---|---|
ALL | 39 | 24 | 2 |
subtype2 | 21 | 7 | 0 |
subtype3 | 18 | 17 | 2 |
P value = 0.844 (t-test), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 68 | 2.9 (3.2) |
subtype2 | 30 | 3.0 (3.5) |
subtype3 | 38 | 2.8 (2.9) |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 22 | 16 | 11 | 21 |
P value = 0.589 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 67 | 26 | 0.0 - 49.4 (7.2) |
subtype1 | 21 | 8 | 0.0 - 17.2 (8.1) |
subtype2 | 16 | 5 | 0.1 - 19.8 (10.8) |
subtype3 | 9 | 5 | 0.1 - 21.9 (7.7) |
subtype4 | 21 | 8 | 0.1 - 49.4 (4.8) |
P value = 0.632 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 70 | 65.6 (10.7) |
subtype1 | 22 | 64.9 (10.5) |
subtype2 | 16 | 63.3 (9.4) |
subtype3 | 11 | 68.2 (12.5) |
subtype4 | 21 | 66.9 (11.0) |
P value = 0.14 (Chi-square test), Q value = 1
nPatients | STAGE IA | STAGE IB | STAGE IIA | STAGE IIB | STAGE III | STAGE IV |
---|---|---|---|---|---|---|
ALL | 2 | 4 | 10 | 50 | 2 | 2 |
subtype1 | 0 | 0 | 4 | 16 | 0 | 2 |
subtype2 | 0 | 0 | 1 | 15 | 0 | 0 |
subtype3 | 1 | 2 | 1 | 7 | 0 | 0 |
subtype4 | 1 | 2 | 4 | 12 | 2 | 0 |
P value = 0.0465 (Fisher's exact test), Q value = 1
nPatients | T1+T2 | T3+T4 |
---|---|---|
ALL | 7 | 63 |
subtype1 | 0 | 22 |
subtype2 | 1 | 15 |
subtype3 | 3 | 8 |
subtype4 | 3 | 18 |
P value = 0.158 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 17 | 52 |
subtype1 | 5 | 17 |
subtype2 | 1 | 15 |
subtype3 | 4 | 7 |
subtype4 | 7 | 13 |
P value = 0.431 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 37 | 2 | 31 |
subtype1 | 12 | 2 | 8 |
subtype2 | 10 | 0 | 6 |
subtype3 | 5 | 0 | 6 |
subtype4 | 10 | 0 | 11 |
P value = 0.669 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 36 | 34 |
subtype1 | 13 | 9 |
subtype2 | 8 | 8 |
subtype3 | 4 | 7 |
subtype4 | 11 | 10 |
P value = 0.225 (Chi-square test), Q value = 1
nPatients | PANCREAS-ADENOCARCINOMA DUCTAL TYPE | PANCREAS-ADENOCARCINOMA-OTHER SUBTYPE | PANCREAS-COLLOID (MUCINOUS NON-CYSTIC) CARCINOMA |
---|---|---|---|
ALL | 62 | 5 | 2 |
subtype1 | 19 | 2 | 0 |
subtype2 | 16 | 0 | 0 |
subtype3 | 9 | 2 | 0 |
subtype4 | 18 | 1 | 2 |
P value = 0.604 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 22 | 24.5 (14.1) |
subtype1 | 10 | 25.1 (13.6) |
subtype2 | 6 | 30.0 (14.8) |
subtype3 | 1 | 1.0 (NA) |
subtype4 | 5 | 21.6 (12.8) |
P value = 0.594 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 19 | 1971.7 (13.9) |
subtype1 | 9 | 1973.0 (12.6) |
subtype2 | 5 | 1975.0 (15.7) |
subtype4 | 5 | 1966.2 (16.0) |
P value = 0.0238 (Chi-square test), Q value = 1
nPatients | R0 | R1 | RX |
---|---|---|---|
ALL | 40 | 24 | 2 |
subtype1 | 7 | 13 | 0 |
subtype2 | 10 | 5 | 0 |
subtype3 | 8 | 2 | 0 |
subtype4 | 15 | 4 | 2 |
P value = 0.477 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 69 | 2.9 (3.2) |
subtype1 | 22 | 2.5 (1.8) |
subtype2 | 16 | 3.9 (4.2) |
subtype3 | 11 | 3.1 (4.5) |
subtype4 | 20 | 2.5 (2.4) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 29 | 16 | 25 |
P value = 0.633 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 67 | 26 | 0.0 - 49.4 (7.2) |
subtype1 | 28 | 12 | 0.2 - 28.0 (9.6) |
subtype2 | 14 | 8 | 0.1 - 49.4 (7.4) |
subtype3 | 25 | 6 | 0.0 - 19.8 (1.5) |
P value = 0.672 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 70 | 65.6 (10.7) |
subtype1 | 29 | 66.2 (10.4) |
subtype2 | 16 | 67.0 (12.7) |
subtype3 | 25 | 64.2 (9.7) |
P value = 0.217 (Chi-square test), Q value = 1
nPatients | STAGE IA | STAGE IB | STAGE IIA | STAGE IIB | STAGE III | STAGE IV |
---|---|---|---|---|---|---|
ALL | 2 | 4 | 10 | 50 | 2 | 2 |
subtype1 | 1 | 1 | 4 | 21 | 0 | 2 |
subtype2 | 1 | 3 | 2 | 9 | 1 | 0 |
subtype3 | 0 | 0 | 4 | 20 | 1 | 0 |
P value = 0.102 (Fisher's exact test), Q value = 1
nPatients | T1+T2 | T3+T4 |
---|---|---|
ALL | 7 | 63 |
subtype1 | 2 | 27 |
subtype2 | 4 | 12 |
subtype3 | 1 | 24 |
P value = 0.083 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 17 | 52 |
subtype1 | 7 | 22 |
subtype2 | 7 | 9 |
subtype3 | 3 | 21 |
P value = 0.406 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 37 | 2 | 31 |
subtype1 | 15 | 2 | 12 |
subtype2 | 7 | 0 | 9 |
subtype3 | 15 | 0 | 10 |
P value = 0.913 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 36 | 34 |
subtype1 | 15 | 14 |
subtype2 | 9 | 7 |
subtype3 | 12 | 13 |
P value = 0.807 (Chi-square test), Q value = 1
nPatients | PANCREAS-ADENOCARCINOMA DUCTAL TYPE | PANCREAS-ADENOCARCINOMA-OTHER SUBTYPE | PANCREAS-COLLOID (MUCINOUS NON-CYSTIC) CARCINOMA |
---|---|---|---|
ALL | 62 | 5 | 2 |
subtype1 | 25 | 2 | 1 |
subtype2 | 14 | 2 | 0 |
subtype3 | 23 | 1 | 1 |
P value = 0.789 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 22 | 24.5 (14.1) |
subtype1 | 10 | 26.9 (11.2) |
subtype2 | 3 | 21.7 (19.6) |
subtype3 | 9 | 22.9 (16.6) |
P value = 0.497 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 19 | 1971.7 (13.9) |
subtype1 | 9 | 1970.8 (13.0) |
subtype2 | 2 | 1960.5 (10.6) |
subtype3 | 8 | 1975.6 (15.4) |
P value = 0.228 (Chi-square test), Q value = 1
nPatients | R0 | R1 | RX |
---|---|---|---|
ALL | 40 | 24 | 2 |
subtype1 | 14 | 12 | 1 |
subtype2 | 13 | 2 | 0 |
subtype3 | 13 | 10 | 1 |
P value = 0.309 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 69 | 2.9 (3.2) |
subtype1 | 29 | 2.6 (2.1) |
subtype2 | 16 | 2.4 (3.6) |
subtype3 | 24 | 3.7 (3.8) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 28 | 16 | 26 |
P value = 0.504 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 67 | 26 | 0.0 - 49.4 (7.2) |
subtype1 | 27 | 10 | 0.0 - 19.3 (7.9) |
subtype2 | 16 | 4 | 0.1 - 19.8 (9.8) |
subtype3 | 24 | 12 | 0.1 - 49.4 (6.7) |
P value = 0.688 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 70 | 65.6 (10.7) |
subtype1 | 28 | 66.0 (10.4) |
subtype2 | 16 | 63.6 (10.2) |
subtype3 | 26 | 66.5 (11.4) |
P value = 0.085 (Chi-square test), Q value = 1
nPatients | STAGE IA | STAGE IB | STAGE IIA | STAGE IIB | STAGE III | STAGE IV |
---|---|---|---|---|---|---|
ALL | 2 | 4 | 10 | 50 | 2 | 2 |
subtype1 | 1 | 0 | 5 | 20 | 0 | 2 |
subtype2 | 0 | 0 | 1 | 15 | 0 | 0 |
subtype3 | 1 | 4 | 4 | 15 | 2 | 0 |
P value = 0.145 (Fisher's exact test), Q value = 1
nPatients | T1+T2 | T3+T4 |
---|---|---|
ALL | 7 | 63 |
subtype1 | 1 | 27 |
subtype2 | 1 | 15 |
subtype3 | 5 | 21 |
P value = 0.0871 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 17 | 52 |
subtype1 | 7 | 21 |
subtype2 | 1 | 15 |
subtype3 | 9 | 16 |
P value = 0.49 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 37 | 2 | 31 |
subtype1 | 13 | 2 | 13 |
subtype2 | 9 | 0 | 7 |
subtype3 | 15 | 0 | 11 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 36 | 34 |
subtype1 | 15 | 13 |
subtype2 | 8 | 8 |
subtype3 | 13 | 13 |
P value = 0.63 (Chi-square test), Q value = 1
nPatients | PANCREAS-ADENOCARCINOMA DUCTAL TYPE | PANCREAS-ADENOCARCINOMA-OTHER SUBTYPE | PANCREAS-COLLOID (MUCINOUS NON-CYSTIC) CARCINOMA |
---|---|---|---|
ALL | 62 | 5 | 2 |
subtype1 | 23 | 3 | 1 |
subtype2 | 16 | 0 | 0 |
subtype3 | 23 | 2 | 1 |
P value = 0.415 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 22 | 24.5 (14.1) |
subtype1 | 11 | 25.8 (13.2) |
subtype2 | 5 | 29.2 (16.4) |
subtype3 | 6 | 18.2 (14.2) |
P value = 0.54 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 19 | 1971.7 (13.9) |
subtype1 | 10 | 1972.5 (12.0) |
subtype2 | 4 | 1976.8 (17.6) |
subtype3 | 5 | 1966.2 (16.0) |
P value = 0.0344 (Chi-square test), Q value = 1
nPatients | R0 | R1 | RX |
---|---|---|---|
ALL | 40 | 24 | 2 |
subtype1 | 11 | 14 | 1 |
subtype2 | 8 | 6 | 1 |
subtype3 | 21 | 4 | 0 |
P value = 0.874 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 69 | 2.9 (3.2) |
subtype1 | 28 | 2.9 (3.3) |
subtype2 | 16 | 3.2 (2.7) |
subtype3 | 25 | 2.7 (3.4) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 21 | 19 | 30 |
P value = 0.196 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 67 | 26 | 0.0 - 49.4 (7.2) |
subtype1 | 21 | 6 | 0.0 - 19.8 (1.4) |
subtype2 | 17 | 8 | 0.1 - 49.4 (7.2) |
subtype3 | 29 | 12 | 0.2 - 19.7 (8.1) |
P value = 0.807 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 70 | 65.6 (10.7) |
subtype1 | 21 | 64.4 (9.2) |
subtype2 | 19 | 65.7 (12.8) |
subtype3 | 30 | 66.4 (10.4) |
P value = 0.184 (Chi-square test), Q value = 1
nPatients | STAGE IA | STAGE IB | STAGE IIA | STAGE IIB | STAGE III | STAGE IV |
---|---|---|---|---|---|---|
ALL | 2 | 4 | 10 | 50 | 2 | 2 |
subtype1 | 0 | 0 | 1 | 19 | 1 | 0 |
subtype2 | 1 | 3 | 3 | 11 | 1 | 0 |
subtype3 | 1 | 1 | 6 | 20 | 0 | 2 |
P value = 0.243 (Fisher's exact test), Q value = 1
nPatients | T1+T2 | T3+T4 |
---|---|---|
ALL | 7 | 63 |
subtype1 | 1 | 20 |
subtype2 | 4 | 15 |
subtype3 | 2 | 28 |
P value = 0.0213 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 17 | 52 |
subtype1 | 1 | 20 |
subtype2 | 7 | 11 |
subtype3 | 9 | 21 |
P value = 0.458 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 37 | 2 | 31 |
subtype1 | 13 | 0 | 8 |
subtype2 | 9 | 0 | 10 |
subtype3 | 15 | 2 | 13 |
P value = 0.73 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 36 | 34 |
subtype1 | 11 | 10 |
subtype2 | 11 | 8 |
subtype3 | 14 | 16 |
P value = 0.471 (Chi-square test), Q value = 1
nPatients | PANCREAS-ADENOCARCINOMA DUCTAL TYPE | PANCREAS-ADENOCARCINOMA-OTHER SUBTYPE | PANCREAS-COLLOID (MUCINOUS NON-CYSTIC) CARCINOMA |
---|---|---|---|
ALL | 62 | 5 | 2 |
subtype1 | 21 | 0 | 0 |
subtype2 | 16 | 2 | 1 |
subtype3 | 25 | 3 | 1 |
P value = 0.689 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 22 | 24.5 (14.1) |
subtype1 | 8 | 23.2 (17.7) |
subtype2 | 5 | 21.0 (13.9) |
subtype3 | 9 | 27.6 (11.6) |
P value = 0.877 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 19 | 1971.7 (13.9) |
subtype1 | 7 | 1973.1 (14.8) |
subtype2 | 4 | 1968.5 (17.4) |
subtype3 | 8 | 1972.1 (13.2) |
P value = 0.0387 (Chi-square test), Q value = 1
nPatients | R0 | R1 | RX |
---|---|---|---|
ALL | 40 | 24 | 2 |
subtype1 | 12 | 7 | 1 |
subtype2 | 16 | 2 | 0 |
subtype3 | 12 | 15 | 1 |
P value = 0.0986 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 69 | 2.9 (3.2) |
subtype1 | 21 | 4.1 (3.9) |
subtype2 | 18 | 2.4 (3.4) |
subtype3 | 30 | 2.3 (2.2) |
-
Cluster data file = PAAD-TP.mergedcluster.txt
-
Clinical data file = PAAD-TP.merged_data.txt
-
Number of patients = 73
-
Number of clustering approaches = 8
-
Number of selected clinical features = 12
-
Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For continuous numerical clinical features, one-way analysis of variance (Howell 2002) was applied to compare the clinical values between tumor subtypes using 'anova' function in R
For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between two tumor subtypes using 't.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.