HotNet pathway analysis of mutation and copy number data
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (Primary solid tumor)
23 September 2013
|
analyses__2013_09_23
Maintainer Information
Citation Information
Maintained by Hailei Zhang
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2013):
HotNet pathway analysis of mutation and copy number data.
Broad Institute of MIT and Harvard.
doi:10.7908/C137771D
Overview
Introduction
Summary
There were 6 significant subnetworks identified in HotNet analysis.
Results
Significant subnetworks
HotNet identifies 6 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.
Table 1. Get Full Table Top 10 out of 6 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.
| Network | No.ofgenes | p-value | RepeatTimes |
|---|---|---|---|
| ARHGEF2(23),F11R(23),CGN(24) | 3 | 0.0425 | 1 |
| ROBO1(20),ROBO2(21),SLIT3(16) | 3 | 0.0425 | 1 |
| TBL1XR1(32),HIST2H2BE(23),HIST1H4F(14) | 3 | 0.0425 | 1 |
| UBE3C(10),PSMC2(10),PSMD2(32) | 3 | 0.0425 | 1 |
| LILRB2(7),HLA-B(14),HLA-F(13),B2M(8),KIR3DL1(7),MAGEA1(9) | 6 | 0.0220 | 1 |
| MAML1(15),NOTCH4(14),NOTCH2(24),ADAM10(8),DLL1(12),JAG2(5) | 6 | 0.0220 | 1 |
Methods & Data
Copyright © 2013
Broad Institute TCGA GDAC as part of the TCGA Research Network.
All rights reserved.