HotNet pathway analysis of mutation and copy number data

Colon Adenocarcinoma (Primary solid tumor)

23 September 2013 | analyses__2013_09_23

Maintainer Information

Citation Information

Maintained by Hailei Zhang (Broad Institute)

Cite as Broad Institute TCGA Genome Data Analysis Center (2013): HotNet pathway analysis of mutation and copy number data. Broad Institute of MIT and Harvard. doi:10.7908/C1K35RZX

- Overview

+ Introduction

- Summary

There were 59 significant subnetworks identified in HotNet analysis.

- Results

- Significant subnetworks

HotNet identifies 59 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.

Table 1. Get Full Table Top 10 out of 59 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.

Network	No.ofgenes	p-value	RepeatTimes
RHOJ(57),DOCK8(24),DOCK10(16)	3	0.000	3
ARF6(56),MPP5(58),EXOC5(57)	3	0.005	2
IL5RA(24),SDC4(109),SDCBP(70)	3	0.005	2
LRP10(57),BMP4(57),HTRA1(37)	3	0.005	2
PPP2R5E(57),SGOL1(25),PPP2R5C(58)	3	0.005	2
TOMM34(108),PRKAG3(11),PRKAA1(32)	3	0.005	2
TRIM9(59),BTRC(35),DLGAP5(57)	3	0.005	2
GLIS3(28),ZNF219(56),STK36(12),SUFU(37)	4	0.010	2
MNAT1(57),HPS6(37),KIAA0020(25),MTA1(57)	4	0.010	2
MXI1(37),SMC3(34),SMC1B(60),MAX(57)	4	0.010	2

+ Methods & Data

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